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Sample records for 1 min 1

  1. USGS 1-min Dst index

    USGS Publications Warehouse

    Gannon, J.L.; Love, J.J.

    2011-01-01

    We produce a 1-min time resolution storm-time disturbance index, the USGS Dst, called Dst8507-4SM. This index is based on minute resolution horizontal magnetic field intensity from low-latitude observatories in Honolulu, Kakioka, San Juan and Hermanus, for the years 1985-2007. The method used to produce the index uses a combination of time- and frequency-domain techniques, which more clearly identifies and excises solar-quiet variation from the horizontal intensity time series of an individual station than the strictly time-domain method used in the Kyoto Dst index. The USGS 1-min Dst is compared against the Kyoto Dst, Kyoto Sym-H, and the USGS 1-h Dst (Dst5807-4SH). In a time series comparison, Sym-H is found to produce more extreme values during both sudden impulses and main phase maximum deviation, possibly due to the latitude of its contributing observatories. Both Kyoto indices are shown to have a peak in their distributions below zero, while the USGS indices have a peak near zero. The USGS 1-min Dst is shown to have the higher time resolution benefits of Sym-H, while using the more typical low-latitude observatories of Kyoto Dst. ?? 2010.

  2. Changes to MFRSRCLDOD1MIN Datastream

    SciTech Connect

    S McFarlane and Y Shi

    2012-05-23

    Significant updates were made to the multifilter rotating shadowband radiometer (MFRSR) cloud optical depth (MFRSRCLDOD) value-added product (VAP) in 2011. The original intent of the update was to add quality control (QC) flags and to update the VAP to use the improved retrievals of liquid water path (LWP) from the Microwave Radiometer Retrievals (MWRRET) VAP rather than the statistical retrievals of LWP from the Microwave Radiometer Line of Sight (MWRLOS) datastream. Although this was originally intended to be a straightforward update of the code, it became more complicated due to the following factors: (1) a new developer and translator team were working with the code; (2) numerous small changes had to be made to the code to consistently implement the QC flags; and (3) ARM standards have changed over the years since the code was originally developed.

  3. The 1-min Screening Test for Reading Problems in College Students: Psychometric Properties of the 1-min TIL.

    PubMed

    Fernandes, Tânia; Araújo, Susana; Sucena, Ana; Reis, Alexandra; Castro, São Luís

    2017-02-01

    Reading is a central cognitive domain, but little research has been devoted to standardized tests for adults. We, thus, examined the psychometric properties of the 1-min version of Teste de Idade de Leitura (Reading Age Test; 1-min TIL), the Portuguese version of Lobrot L3 test, in three experiments with college students: typical readers in Experiment 1A and B, dyslexic readers and chronological age controls in Experiment 2. In Experiment 1A, test-retest reliability and convergent validity were evaluated in 185 students. Reliability was >.70, and phonological decoding underpinned 1-min TIL. In Experiment 1B, internal consistency was assessed by presenting two 45-s versions of the test to 19 students, and performance in these versions was significantly associated (r = .78). In Experiment 2, construct validity, criterion validity and clinical utility of 1-min TIL were investigated. A multiple regression analysis corroborated construct validity; both phonological decoding and listening comprehension were reliable predictors of 1-min TIL scores. Logistic regression and receiver operating characteristics analyses revealed the high accuracy of this test in distinguishing dyslexic from typical readers. Therefore, the 1-min TIL, which assesses reading comprehension and potential reading difficulties in college students, has the necessary psychometric properties to become a useful screening instrument in neuropsychological assessment and research. Copyright © 2017 John Wiley & Sons, Ltd.

  4. Estimating 1 min rain rate distributions from numerical weather prediction

    NASA Astrophysics Data System (ADS)

    Paulson, Kevin S.

    2017-01-01

    Internationally recognized prognostic models of rain fade on terrestrial and Earth-space EHF links rely fundamentally on distributions of 1 min rain rates. Currently, in Rec. ITU-R P.837-6, these distributions are generated using the Salonen-Poiares Baptista method where 1 min rain rate distributions are estimated from long-term average annual accumulations provided by numerical weather prediction (NWP). This paper investigates an alternative to this method based on the distribution of 6 h accumulations available from the same NWPs. Rain rate fields covering the UK, produced by the Nimrod network of radars, are integrated to estimate the accumulations provided by NWP, and these are linked to distributions of fine-scale rain rates. The proposed method makes better use of the available data. It is verified on 15 NWP regions spanning the UK, and the extension to other regions is discussed.

  5. Study of 1-min rain rate integration statistic in South Korea

    NASA Astrophysics Data System (ADS)

    Shrestha, Sujan; Choi, Dong-You

    2017-03-01

    The design of millimeter wave communication links and the study of propagation impairments at higher frequencies due to a hydrometeor, particularly rain, require the knowledge of 1-min. rainfall rate data. Signal attenuation in space communication results are due to absorption and scattering of radio wave energy. Radio wave attenuation due to rain depends on the relevance of a 1-min. integration time for the rain rate. However, in practice, securing these data over a wide range of areas is difficult. Long term precipitation data are readily available. However, there is a need for a 1-min. rainfall rate in the rain attenuation prediction models for a better estimation of the attenuation. In this paper, we classify and survey the prominent 1-min. rain rate models. Regression analysis was performed for the study of cumulative rainfall data measured experimentally for a decade in nine different regions in South Korea, with 93 different locations, using the experimental 1-min. rainfall accumulation. To visualize the 1-min. rainfall rate applicable for the whole region for 0.01% of the time, we have considered the variation in the rain rate for 40 stations across South Korea. The Kriging interpolation method was used for spatial interpolation of the rain rate values for 0.01% of the time into a regular grid to obtain a highly consistent and predictable rainfall variation. The rain rate exceeded the 1-min. interval that was measured through the rain gauge compared to the rainfall data estimated using the International Telecommunication Union Radio Communication Sector model (ITU-R P.837-6) along with the empirical methods as Segal, Burgueno et al., Chebil and Rahman, logarithmic, exponential and global coefficients, second and third order polynomial fits, and Model 1 for Icheon regions under the regional and average coefficient set. The ITU-R P. 837-6 exhibits a lower relative error percentage of 3.32% and 12.59% in the 5- and 10-min. to 1-min. conversion, whereas the

  6. A multicentre validation of the 1-min sit-to-stand test in patients with COPD.

    PubMed

    Crook, Sarah; Büsching, Gilbert; Schultz, Konrad; Lehbert, Nicola; Jelusic, Danijel; Keusch, Stephan; Wittmann, Michael; Schuler, Michael; Radtke, Thomas; Frey, Martin; Turk, Alexander; Puhan, Milo A; Frei, Anja

    2017-03-01

    Our aim was to comprehensively validate the 1-min sit-to-stand (STS) test in chronic obstructive pulmonary disease (COPD) patients and explore the physiological response to the test.We used data from two longitudinal studies of COPD patients who completed inpatient pulmonary rehabilitation programmes. We collected 1-min STS test, 6-min walk test (6MWT), health-related quality of life, dyspnoea and exercise cardiorespiratory data at admission and discharge. We assessed the learning effect, test-retest reliability, construct validity, responsiveness and minimal important difference of the 1-min STS test.In both studies (n=52 and n=203) the 1-min STS test was strongly correlated with the 6MWT at admission (r=0.59 and 0.64, respectively) and discharge (r=0.67 and 0.68, respectively). Intraclass correlation coefficients (95% CI) between 1-min STS tests were 0.93 (0.83-0.97) for learning effect and 0.99 (0.97-1.00) for reliability. Standardised response means (95% CI) were 0.87 (0.58-1.16) and 0.91 (0.78-1.07). The estimated minimal important difference was three repetitions. End-exercise oxygen consumption, carbon dioxide output, ventilation, breathing frequency and heart rate were similar in the 1-min STS test and 6MWT.The 1-min STS test is a reliable, valid and responsive test for measuring functional exercise capacity in COPD patients and elicited a physiological response comparable to that of the 6MWT.

  7. Global statistical maps of extreme-event magnetic observatory 1 min first differences in horizontal intensity

    USGS Publications Warehouse

    Love, Jeffrey J.; Coisson, Pierdavide; Pulkkinen, Antti

    2016-01-01

    Analysis is made of the long-term statistics of three different measures of ground level, storm time geomagnetic activity: instantaneous 1 min first differences in horizontal intensity ΔBh, the root-mean-square of 10 consecutive 1 min differences S, and the ramp change R over 10 min. Geomagnetic latitude maps of the cumulative exceedances of these three quantities are constructed, giving the threshold (nT/min) for which activity within a 24 h period can be expected to occur once per year, decade, and century. Specifically, at geomagnetic 55°, we estimate once-per-century ΔBh, S, and R exceedances and a site-to-site, proportional, 1 standard deviation range [1 σ, lower and upper] to be, respectively, 1000, [690, 1450]; 500, [350, 720]; and 200, [140, 280] nT/min. At 40°, we estimate once-per-century ΔBh, S, and R exceedances and 1 σ values to be 200, [140, 290]; 100, [70, 140]; and 40, [30, 60] nT/min.

  8. Rain rate modeling of 1-min from various integration times in South Korea.

    PubMed

    Shrestha, Sujan; Park, Jung-Jin; Choi, Dong-You

    2016-01-01

    Rain plays a major impairment factor for propagation of electromagnetic waves in atmosphere for systems operating at frequencies above 10 GHz. Several effects are noted such as depolarization, scintillation, interference due to scattering and extra attenuation which seems to increase with frequency. To mitigate its effect in satellite communication, knowledge of local rainfall statistics is necessary which act as milestone for design of radio link. Rain attenuation is best visualize by the 1-min rainfall rate statistic but the measurement of this rain rate distribution is rare on a worldwide basis and observation of rain rate are done with longer integration times typically 30 min or more. In this paper, efforts have been made to develop model that can convert rain rate complementary cumulative distribution function to shorter integration times. The average relative error margin of about 5, 14, 43, 71 and 115 % are noted for 5 to 1-, 10 to 1-, 20 to 1, 30 to 1- and 60 to 1-min respectively from ITU-R P.837-6 method which have been analyzed in further section of this article. The empirical natures of conversion methods as such Segal method, Burgueno's method, Chebil and Rahman method and Logarithmic model are studied along with the proposed new model that seems to be applicable in derivation of 1-min rain rate of the South Korea rain rate statistics. International Telecommunication Union-Radio communication Sector (ITU-R) has developed a recommendation ITU-R P.837-6 that enables the user to estimate the local 1-min rainfall rate statistical distribution which is compared with calculated 1-min rain rate distribution from experimental 1-min rainfall accumulation. Unfortunately, ITU-R P.837-6 estimated 1-min values show greater error percentages. In order to get better approximation of local 1-min rain rate estimation, a novel method is proposed and it's efficiency have been compared with rainfall rate statistics obtained from nine different locations in the South

  9. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.

    PubMed

    Wauson, Eric M; Guerra, Marcy L; Dyachok, Julia; McGlynn, Kathleen; Giles, Jennifer; Ross, Elliott M; Cobb, Melanie H

    2015-08-01

    The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the mechanistic target of rapamycin complex 1 (mTORC1) to regulate protein synthesis. We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic β-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor. We show here that AAs differentially activate these two signaling pathways in MIN6 cells. Pretreatment with pertussis toxin did not prevent the activation of either ERK1/2 or mTORC1 by AAs, indicating that G(I) is not central to either pathway. Although glucagon-like peptide 1, an agonist for a G(s-)coupled receptor, activated ERK1/2 well and mTORC1 to a small extent, AAs had no effect on cytosolic cAMP accumulation. Ca(2+) entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1. Pretreatment with UBO-QIC, a selective G(q) inhibitor, reduced the activation of ERK1/2 but had little effect on the activation of mTORC1 by AAs, suggesting a differential requirement for G(q). Inhibition of G(12/13) by the overexpression of the regulator of G protein signaling domain of p115 ρ-guanine nucleotide exchange factor had no effect on mTORC1 activation by AAs, suggesting that these G proteins are also not involved. We conclude that AAs regulate ERK1/2 and mTORC1 through distinct signaling pathways.

  10. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

    PubMed Central

    Wauson, Eric M.; Guerra, Marcy L.; Dyachok, Julia; McGlynn, Kathleen; Giles, Jennifer; Ross, Elliott M.

    2015-01-01

    The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the mechanistic target of rapamycin complex 1 (mTORC1) to regulate protein synthesis. We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic β-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor. We show here that AAs differentially activate these two signaling pathways in MIN6 cells. Pretreatment with pertussis toxin did not prevent the activation of either ERK1/2 or mTORC1 by AAs, indicating that Gi is not central to either pathway. Although glucagon-like peptide 1, an agonist for a Gs-coupled receptor, activated ERK1/2 well and mTORC1 to a small extent, AAs had no effect on cytosolic cAMP accumulation. Ca2+ entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1. Pretreatment with UBO-QIC, a selective Gq inhibitor, reduced the activation of ERK1/2 but had little effect on the activation of mTORC1 by AAs, suggesting a differential requirement for Gq. Inhibition of G12/13 by the overexpression of the regulator of G protein signaling domain of p115 ρ-guanine nucleotide exchange factor had no effect on mTORC1 activation by AAs, suggesting that these G proteins are also not involved. We conclude that AAs regulate ERK1/2 and mTORC1 through distinct signaling pathways. PMID:26168033

  11. Global Statistical Maps of Extreme-Event Magnetic Observatory 1 Min First Differences in Horizontal Intensity

    NASA Technical Reports Server (NTRS)

    Love, Jeffrey J.; Coïsson, Pierdavide; Pulkkinen, Antti

    2016-01-01

    Analysis is made of the long-term statistics of three different measures of ground level, storm time geomagnetic activity: instantaneous 1 min first differences in horizontal intensity (delta)Bh, the root-mean-square of 10 consecutive 1 min differences S, and the ramp change R over 10 min. Geomagnetic latitude maps of the cumulative exceedances of these three quantities are constructed, giving the threshold(nTmin) for which activity within a 24 h period can be expected to occur once per year, decade, and century. Specifically, at geomagnetic 55deg, we estimate once-per-century (delta)Bh, S, and R exceedances and a site-to-site,proportional, 1 standard deviation range [1(sigma), lower and upper] to be, respectively, 1000, [690, 1450]; 500,[350, 720]; and 200, [140, 280] nTmin. At 40deg, we estimate once-per-century (delta)Bh, S, and R exceedances and1(sigma) values to be 200, [140, 290]; 100, [70, 140]; and 40, [30, 60] nTmin.

  12. MinION Analysis and Reference Consortium: Phase 1 data release and analysis.

    PubMed

    Ip, Camilla L C; Loose, Matthew; Tyson, John R; de Cesare, Mariateresa; Brown, Bonnie L; Jain, Miten; Leggett, Richard M; Eccles, David A; Zalunin, Vadim; Urban, John M; Piazza, Paolo; Bowden, Rory J; Paten, Benedict; Mwaigwisya, Solomon; Batty, Elizabeth M; Simpson, Jared T; Snutch, Terrance P; Birney, Ewan; Buck, David; Goodwin, Sara; Jansen, Hans J; O'Grady, Justin; Olsen, Hugh E

    2015-01-01

    The advent of a miniaturized DNA sequencing device with a high-throughput contextual sequencing capability embodies the next generation of large scale sequencing tools. The MinION™ Access Programme (MAP) was initiated by Oxford Nanopore Technologies™ in April 2014, giving public access to their USB-attached miniature sequencing device. The MinION Analysis and Reference Consortium (MARC) was formed by a subset of MAP participants, with the aim of evaluating and providing standard protocols and reference data to the community. Envisaged as a multi-phased project, this study provides the global community with the Phase 1 data from MARC, where the reproducibility of the performance of the MinION was evaluated at multiple sites. Five laboratories on two continents generated data using a control strain of Escherichia coli K-12, preparing and sequencing samples according to a revised ONT protocol. Here, we provide the details of the protocol used, along with a preliminary analysis of the characteristics of typical runs including the consistency, rate, volume and quality of data produced. Further analysis of the Phase 1 data presented here, and additional experiments in Phase 2 of E. coli from MARC are already underway to identify ways to improve and enhance MinION performance.

  13. MinION Analysis and Reference Consortium: Phase 1 data release and analysis

    PubMed Central

    Eccles, David A.; Zalunin, Vadim; Urban, John M.; Piazza, Paolo; Bowden, Rory J.; Paten, Benedict; Mwaigwisya, Solomon; Batty, Elizabeth M.; Simpson, Jared T.; Snutch, Terrance P.

    2015-01-01

    The advent of a miniaturized DNA sequencing device with a high-throughput contextual sequencing capability embodies the next generation of large scale sequencing tools. The MinION™ Access Programme (MAP) was initiated by Oxford Nanopore Technologies™ in April 2014, giving public access to their USB-attached miniature sequencing device. The MinION Analysis and Reference Consortium (MARC) was formed by a subset of MAP participants, with the aim of evaluating and providing standard protocols and reference data to the community. Envisaged as a multi-phased project, this study provides the global community with the Phase 1 data from MARC, where the reproducibility of the performance of the MinION was evaluated at multiple sites. Five laboratories on two continents generated data using a control strain of Escherichia coli K-12, preparing and sequencing samples according to a revised ONT protocol. Here, we provide the details of the protocol used, along with a preliminary analysis of the characteristics of typical runs including the consistency, rate, volume and quality of data produced. Further analysis of the Phase 1 data presented here, and additional experiments in Phase 2 of E. coli from MARC are already underway to identify ways to improve and enhance MinION performance. PMID:26834992

  14. Novel I1-Imidazoline Agonist S43126 Augment Insulin Secretion in Min6 Cells

    PubMed Central

    Tesfai, Jerusalem; Crane, Louis; Baziard-Mouysset, Genevieve; Edwards, Lincoln P.

    2016-01-01

    The I1-imidazoline receptor is a novel drug target for hypertension and insulin resistance which are major disorders associated with Type II diabetes. In the present study, we examined the effects of a novel imidazoline agonist S43126 on calcium fluxes and insulin secretion from Min6 β-cells. We also examined the effects of S43126 on the induction of IRAS, and phosphorylation of components in the I1-imidazoline signaling pathways, namely ERK and PKB. Min6 β-cells were treated with varying doses of S43126 [10−8M to 10−5M] for various time (5–60mins). S43126 at higher dose [10−5M] stimulated insulin secretion under elevated glucose concentration compared to basal. In addition, insulin secretion and Ca2+ influx mediated by S43126 [10−5M] were decreased following co-treatment with efaroxan (I1-antagonist) and nifedipine (L-type voltage-gated Ca2+-channel blocker) at various times (5–60mins). Furthermore, S43126 at [10−5M] increased Ca2+ oscillation, [Ca2+] and 45Ca2+ uptake in a time and dose-dependent manner. Moreover, Western blot analysis of treated samples showed that S43126 caused an increased protein expression of IRAS as well as phosphorylation of both ERK1/2 and PKB in a concentration-dependent manner. We conclude that S43126 exerts its insulinotropic effect in a glucose dependent manner by a mechanism involving L-type calcium channels and imidazoline I1-receptors. PMID:27429837

  15. Statistical properties of superflares on solar-type stars based on 1-min cadence data

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Shibayama, Takuya; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    2015-04-01

    We searched for superflares on solar-type stars using Kepler data with 1-min sampling in order to detect superflares with a short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of 1032 to 1036 erg. Some superflares show multiple peaks with the peak separation of the order of 100 to 1,000 s which is comparable to the periods of quasi-periodic pulsations in solar and stellar flares. Using these new data combined with the results from the data with 30-min sampling, we found that the occurrence frequency (dN/dE) of superflares as a function of flare energy ( E) shows the power-law distribution (dN/dE∝ E - α ) with α˜-1.5 for 1033< E<1036 erg which is consistent with the previous results. The average occurrence rate of superflares with the energy of 1033 erg which is equivalent to X100 solar flares is about once in 500 to 600 years. The upper limit of energy released by superflares is basically comparable to a fraction of the magnetic energy stored near starspots which is estimated from the photometry. We also found that the duration of superflares ( τ) increases with the flare energy ( E) as τ∝ E 0.39 ± 0.03. This can be explained if we assume the time scale of flares is determined by the Alfvén time.

  16. Breast MRI at Very Short TE (minTE): Image Analysis of minTE Sequences on Non-Fat-Saturated, Subtracted T1-Weighted Images.

    PubMed

    Wenkel, Evelyn; Janka, Rolf; Geppert, Christian; Kaemmerer, Nadine; Hartmann, Arndt; Uder, Michael; Hammon, Matthias; Brand, Michael

    2017-02-01

    Purpose The aim was to evaluate a minimum echo time (minTE) protocol for breast magnetic resonance imaging (MRI) in patients with breast lesions compared to a standard TE (nTE) time protocol. Methods Breasts of 144 women were examined with a 1.5 Tesla MRI scanner. Additionally to the standard gradient-echo sequence with nTE (4.8 ms), a variant with minimum TE (1.2 ms) was used in an interleaved fashion which leads to a better temporal resolution and should reduce the scan time by approximately 50 %. Lesion sizes were measured and the signal-to-noise ratio (SNR) as well as the contrast-to-noise ratio (CNR) were calculated. Subjective confidence was evaluated using a 3-point scale before looking at the nTE sequences (1 = very sure that I can identify a lesion and classify it, 2 = quite sure that I can identify a lesion and classify it, 3 = definitely want to see nTE for final assessment) and the subjective image quality of all examinations was evaluated using a four-grade scale (1 = sharp, 2 = slight blur, 3 = moderate blur and 4 = severe blur/not evaluable) for lesion and skin sharpness. Lesion morphology and contrast enhancement were also evaluated. Results With minTE sequences, no lesion was rated with "definitely want to see nTE sequences for final assessment". The difference of the longitudinal and transverse diameter did not differ significantly (p > 0.05). With minTE, lesions and skin were rated to be significantly more blurry (p < 0.01 for lesions and p < 0.05 for skin). There was no difference between both sequences with respect to SNR, CNR, lesion morphology, contrast enhancement and detection of multifocal disease. Conclusion Dynamic breast MRI with a minTE protocol is feasible without a major loss of information (SNR, CNR, lesion morphology, contrast enhancement and lesion sizes) and the temporal resolution can be increased by a factor of 2 using minTE sequences. Key points  · Increase of temporal

  17. Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.

    PubMed

    Arnason, Thomas; Pino, Maria S; Yilmaz, Omer; Kirley, Sandra D; Rueda, Bo R; Chung, Daniel C; Zukerberg, Lawrence R

    2013-07-01

    The transformation of colonic mucosal epithelium to adenocarcinoma requires progressive oncogene activation and tumor suppressor gene inactivation. Loss of chromosome 18q is common in colon cancer but not in precancerous adenomas. A few candidate tumor suppressor genes have been identified in this region, including CABLES1 at 18q11.2-12.1. This study investigates the role of CABLES1 in an in vivo mouse model of intestinal adenocarcinoma and in human colon cancer cell culture. Apc(Min/+) mice were crossed with mice harboring targeted inactivation of the Cables1 gene (Cables1(-/-)). The intestinal tumor burden and tumor expression of β-catenin and PCNA was compared in Cables1(+/+)Apc(Min/+) and Cables1(-/-)Apc(Min/+) mice. β-catenin activity in human colon cancer cells with CABLES1 inactivation and intestinal progenitor cell function in Cables1(-/-) mice were assayed in vitro. The mean number of small intestinal tumors per mouse was 3.1 ± 0.6 in Cables1(+/+)Apc(Min/+) mice, compared with 32.4 ± 3.5 in the Cables1(-/-)Apc(Min/+) mice (P < 0.0001). Fewer colonic tumors were observed in Cables1(+/+)Apc(Min/+) mice (mean 0.6 ± 0.1) compared with the Cables1(-/-)Apc(Min/+) mice (mean 1.3 ± 0.3, P = 0.01). Tumors from Cables1(-/-)Apc(Min/+) mice demonstrated increased nuclear expression of β-catenin and an increased number of PCNA-positive cells. In vitro studies revealed that CABLES1 deficiency increased β-catenin dependent transcription and increased intestinal progenitor cell activity. Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/β-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model and likely has a similar role in human colon cancer.

  18. Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer

    PubMed Central

    Soto-Pantoja, D R; Sipes, J M; Martin-Manso, G; Westwood, B; Morris, N L; Ghosh, A; Emenaker, N J; Roberts, D D

    2016-01-01

    Thrombospondin 1 is a glycoprotein that regulates cellular phenotype through interactions with its cellular receptors and extracellular matrix-binding partners. Thrombospondin 1 locally regulates angiogenesis and inflammatory responses that contribute to colorectal carcinogenesis in ApcMin/+ mice. The ability of thrombospondin 1 to regulate responses of cells and tissues to a variety of stresses suggested that loss of thrombospondin 1 may also have broader systemic effects on metabolism to modulate carcinogenesis. ApcMin/+:Thbs1−/− mice exhibited decreased survival and higher tumor multiplicities in the small and large intestine relative to ApcMin/+ mice when fed a low (5%) fat western diet. However, the protective effect of endogenous thrombospondin 1 was lost when the mice were fed a western diet containing 21% fat. Biochemical profiles of liver tissue identified systemic metabolic changes accompanying the effects of thrombospondin 1 and dietary lipid intake on tumorigenesis. A high-fat western diet differentially regulated elements of amino acid, energy and lipid metabolism in ApcMin/+:Thbs1−/− mice relative to ApcMin/+:Thbs1+/+mice. Metabolic changes in ketone body and tricarboxylic acid cycle intermediates indicate functional interactions between Apc and thrombospondin 1 signaling that control mitochondrial function. The cumulative diet-dependent differential changes observed in ApcMin/+:Thbs1−/− versus ApcMin/+ mice include altered amino acid and lipid metabolism, mitochondrial dysfunction, eicosanoids and ketone body formation. This metabolic profile suggests that the protective role of thrombospondin 1 to decrease adenoma formation in ApcMin/+ mice results in part from improved mitochondrial function. PMID:27239962

  19. The Arabidopsis minE mutation causes new plastid and FtsZ1 localization phenotypes in the leaf epidermis.

    PubMed

    Fujiwara, Makoto T; Kojo, Kei H; Kazama, Yusuke; Sasaki, Shun; Abe, Tomoko; Itoh, Ryuuichi D

    2015-01-01

    Plastids in the leaf epidermal cells of plants are regarded as immature chloroplasts that, like mesophyll chloroplasts, undergo binary fission. While mesophyll chloroplasts have generally been used to study plastid division, recent studies have suggested the presence of tissue- or plastid type-dependent regulation of plastid division. Here, we report the detailed morphology of plastids and their stromules, and the intraplastidic localization of the chloroplast division-related protein AtFtsZ1-1, in the leaf epidermis of an Arabidopsis mutant that harbors a mutation in the chloroplast division site determinant gene AtMinE1. In atminE1, the size and shape of epidermal plastids varied widely, which contrasts with the plastid phenotype observed in atminE1 mesophyll cells. In particular, atminE1 epidermal plastids occasionally displayed grape-like morphology, a novel phenotype induced by a plastid division mutation. Observation of an atminE1 transgenic line harboring an AtMinE1 promoter::AtMinE1-yellow fluorescent protein fusion gene confirmed the expression and plastidic localization of AtMinE1 in the leaf epidermis. Further examination revealed that constriction of plastids and stromules mediated by the FtsZ1 ring contributed to the plastid pleomorphism in the atminE1 epidermis. These results illustrate that a single plastid division mutation can have dramatic consequences for epidermal plastid morphology, thereby implying that plastid division and morphogenesis are differentially regulated in epidermal and mesophyll plastids.

  20. The Arabidopsis minE mutation causes new plastid and FtsZ1 localization phenotypes in the leaf epidermis

    PubMed Central

    Fujiwara, Makoto T.; Kojo, Kei H.; Kazama, Yusuke; Sasaki, Shun; Abe, Tomoko; Itoh, Ryuuichi D.

    2015-01-01

    Plastids in the leaf epidermal cells of plants are regarded as immature chloroplasts that, like mesophyll chloroplasts, undergo binary fission. While mesophyll chloroplasts have generally been used to study plastid division, recent studies have suggested the presence of tissue- or plastid type-dependent regulation of plastid division. Here, we report the detailed morphology of plastids and their stromules, and the intraplastidic localization of the chloroplast division-related protein AtFtsZ1-1, in the leaf epidermis of an Arabidopsis mutant that harbors a mutation in the chloroplast division site determinant gene AtMinE1. In atminE1, the size and shape of epidermal plastids varied widely, which contrasts with the plastid phenotype observed in atminE1 mesophyll cells. In particular, atminE1 epidermal plastids occasionally displayed grape-like morphology, a novel phenotype induced by a plastid division mutation. Observation of an atminE1 transgenic line harboring an AtMinE1 promoter::AtMinE1-yellow fluorescent protein fusion gene confirmed the expression and plastidic localization of AtMinE1 in the leaf epidermis. Further examination revealed that constriction of plastids and stromules mediated by the FtsZ1 ring contributed to the plastid pleomorphism in the atminE1 epidermis. These results illustrate that a single plastid division mutation can have dramatic consequences for epidermal plastid morphology, thereby implying that plastid division and morphogenesis are differentially regulated in epidermal and mesophyll plastids. PMID:26500667

  1. Bactericidal efficacy of a 1.5min surgical hand-rubbing protocol under in-use conditions.

    PubMed

    Kac, G; Masmejean, E; Gueneret, M; Rodi, A; Peyrard, S; Podglajen, I

    2009-06-01

    In healthy volunteers, surgical hand rubbing with Sterillium for 1.5min has been shown to be as effective as a 3min procedure. The aim of this study was to assess whether this result was reproducible under in-use conditions. During nine weeks in the ambulatory surgery theatre of a 750-bed tertiary care university hospital, the two surgical hand-rubbing procedures were compared with each other, and with a hand-scrubbing procedure using a povidone-iodine (4%) scrub prior to and after 25 different surgical operations for each. Imprints of the surgeon's dominant hand were taken on culture plates before and within 1min following the end of the hand-rubbing/scrubbing procedures (immediate effect) and at the end of surgery (sustained effect). Plates were incubated aerobically at 37 degrees C for 48h. Colonies were counted at 24h and 48h. Results were expressed as the number of colony-forming units per hand. No significant difference in baseline hand bacterial load was found before the hand-rubbing/scrubbing procedures among the three groups (P=0.19). With respect to immediate and sustained antimicrobial effects, a significantly greater reduction in microbial loads on the hands was achieved with the 3min hand-rubbing protocol as opposed to hand-scrubbing protocol (P=0.04 and P=0.02, respectively), but there was no difference between the reductions obtained with 1.5 and 3min rubbing protocols (P=0.41 and P=0.36, respectively). Surgical hand rubbing with Sterillium using a 1.5min protocol should be considered as an attractive alternative method for surgical hand disinfection.

  2. Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise

    PubMed Central

    Vendelbo, M. H.; Møller, A. B.; Treebak, J. T.; Gormsen, L. C.; Goodyear, L. J.; Wojtaszewski, J. F. P.; Jørgensen, J. O. L.; Møller, N.

    2014-01-01

    Background: phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4 mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in response to acute exercise is not fully characterized. Objective: to study AS160 and TBC1D1 phosphorylation in human skeletal muscle after aerobic exercise followed by a hyperinsulinemic euglycemic clamp. Design: eight healthy men were studied on two occasions: 1) in the resting state and 2) in the hours after a 1-h bout of ergometer cycling. A hyperinsulinemic euglycemic clamp was initiated 240 min after exercise and in a time-matched nonexercised control condition. We obtained muscle biopsies 30 min after exercise and in a time-matched nonexercised control condition (t = 30) and after 30 min of insulin stimulation (t = 270) and investigated site-specific phosphorylation of AS160 and TBC1D1. Results: phosphorylation on AS160 and TBC1D1 was increased 30 min after the exercise bout, whereas phosphorylation of the putative upstream kinases, Akt and AMPK, was unchanged compared with resting control condition. Exercise augmented insulin-stimulated phosphorylation on AS160 at Ser341 and Ser704 270 min after exercise. No additional exercise effects were observed on insulin-stimulated phosphorylation of Thr642 and Ser588 on AS160 or Ser237 and Thr596 on TBC1D1. Conclusions: AS160 and TBC1D1 phosphorylations were evident 30 min after exercise without simultaneously increased Akt and AMPK phosphorylation. Unlike TBC1D1, insulin-stimulated site-specific AS160 phosphorylation is modified by prior exercise, but these sites do not include Thr642 and Ser588. Together, these data provide new insights into phosphorylation of key regulators of glucose transport in human skeletal muscle. PMID:24876356

  3. MinVar: A rapid and versatile tool for HIV-1 drug resistance genotyping by deep sequencing.

    PubMed

    Huber, Michael; Metzner, Karin J; Geissberger, Fabienne D; Shah, Cyril; Leemann, Christine; Klimkait, Thomas; Böni, Jürg; Trkola, Alexandra; Zagordi, Osvaldo

    2017-02-01

    Genotypic monitoring of drug-resistance mutations (DRMs) in HIV-1 infected individuals is strongly recommended to guide selection of the initial antiretroviral therapy (ART) and changes of drug regimens. Traditionally, mutations conferring drug resistance are detected by population sequencing of the reverse transcribed viral RNA encoding the HIV-1 enzymes target by ART, followed by manual analysis and interpretation of Sanger sequencing traces. This process is labor intensive, relies on subjective interpretation from the operator, and offers limited sensitivity as only mutations above 20% frequency can be reliably detected. Here we present MinVar, a pipeline for the analysis of deep sequencing data, which allows reliable and automated detection of DRMs down to 5%. We evaluated MinVar with data from amplicon sequencing of defined mixtures of molecular virus clones with known DRM and plasma samples of viremic HIV-1 infected individuals and we compared it to VirVarSeq, another virus variant detection tool exclusively working on Illumina deep sequencing data. MinVar was designed to be compatible with a diverse range of sequencing platforms and allows the detection of DRMs and insertions/deletions from deep sequencing data without the need to perform additional bioinformatics analysis, a prerequisite to a widespread implementation of HIV-1 genotyping using deep sequencing in routine diagnostic settings.

  4. Safety and efficacy of total dose infusion of 1,020 mg of ferumoxytol administered over 15 min.

    PubMed

    Auerbach, Michael; Strauss, William; Auerbach, Sarah; Rineer, Stella; Bahrain, Huzefa

    2013-11-01

    For the majority of patients with iron deficiency anemia (IDA), a full course of intravenous (IV) iron is 1 g. Most IV irons require 5-10 administrations of 100-300 mg. We have successfully employed 1 g low molecular weight iron dextran over 1 hr. For further convenience for patients and physicians, we explored the administration of 1.02 g of ferumoxytol over 15 min instead of the approved 2 × 510 mg injections. Sixty patients with IDA, (hemoglobin <11 g/dL, transferrin saturation [TSAT] ≤20%, and ferritin <100 ng/mL) with an inadequate response or intolerance to oral iron, received 1020 mg ferumoxytol over 15 min. Vital signs were measured for 1 hr. Adverse events (AEs) were collected via telephone at 1, 2, and 7 days. Follow-up visits occurred at 4 and 8 weeks for efficacy assessments. The primary endpoint was safety and tolerability. Secondary efficacy endpoints included mean change in hemoglobin, TSAT, and red cell distribution width. No serious adverse events (SAEs) occurred. Fifty-eight patients received the planned dose. Twenty-six out of sixty (43.3%) patients reported AEs of which 13 were mild and transient during infusion. All resolved within minutes. Fourteen patients reported self-limited arthralgias, myalgias, and/or headache within 24-48 hr. At Baseline, the mean hemoglobin was 9.4 g/dL. The mean increments at Week 4 and 8 were 2.1 and 2.6 g/dL, respectively. Ferumoxytol, administered as 1.02 g infusion over 15 min was well tolerated with no SAEs and demonstrated excellent efficacy. If corroborated in future studies this represents an improved method of treating IDA.

  5. Transcription of TIR1-Controlled Genes Can be Regulated within 10 Min by an Auxin-Induced Process. Can TIR1 be the Receptor?

    PubMed Central

    Labusch, Corinna; Effendi, Yunus; Fulda, Martin; Scherer, Günther F. E.

    2016-01-01

    ABP1 and TIR1/AFBs are known as auxin receptors. ABP1 is linked to auxin responses several of which are faster than 10 min. TIR1 regulates auxin-induced transcription of early auxin genes also within minutes. We use transcription of such TIR1-dependent genes as indicator of TIR1 activity to show the rapid regulation of TIR1 by exogenous auxin. To this end, we used quantification of transcription of a set of fifteen early auxin-induced reporter genes at t = 10 and t = 30 min to measure this as a TIR1-dependent auxin response. We conducted this study in 22 mutants of auxin transporters (pin5, abcb1, abcb19, and aux1/lax3), protein kinases and phosphatases (ibr5, npr1, cpk3, CPK3-OX, d6pk1, d6pkl1-1, d6pkl3-2, d6pkl1-1/d6pkl2-2, and d6pkl1-1/d6pkl3-2), of fatty acid metabolism (fad2-1, fad6-1, ssi2, lacs4, lacs9, and lacs4/lacs9) and receptors (tir1, tir1/afb2, and tir1/afb3) and compared them to the wild type. After 10 min auxin application, in 18 out of 22 mutants mis-regulated expression of at least one reporter was found, and in 15 mutants transcription of two-to-three out of five selected auxin reporter genes was mis-regulated. After 30 min of auxin application to mutant plants, mis-regulation of reporter genes ranged from one to 13 out of 15 tested reporter genes. Those genes chosen as mutants were themselves not regulated in their expression by auxin for at least 1 h, excluding an influence of TIR1/AFBs on their transcription. The expression of TIR1/AFB genes was also not modulated by auxin for up to 3 h. Together, this excludes a feedback or feedforward of these mutant genes/proteins on TIR1/AFBs output of transcription in this auxin-induced response. However, an auxin-induced response needed an as yet unknown auxin receptor. We suggest that the auxin receptor necessary for the fast auxin-induced transcription modulation could be, instead, ABP1. The alternative hypothesis would be that auxin-induced expression of a protein, initiated by TIR1/AFBs receptors

  6. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion.

    PubMed

    Cao, Zhijuan; Balasubramanian, Adithya; Marrelli, Sean P

    2014-01-15

    Traditional methods of therapeutic hypothermia show promise for neuroprotection against cerebral ischemia-reperfusion (I/R), however, with limitations. We examined effectiveness and specificity of pharmacological hypothermia (PH) by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (T(core)) was measured after subcutaneous infusion of TRPV1 agonist dihydrocapsaicin (DHC) in conscious C57BL/6 WT and TRPV1 knockout (KO) mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (1 h ischemia + 24 h reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (>8 h) was initiated 90 min after start of reperfusion by DHC infusion (osmotic pump). Neurofunction (behavioral testing) and infarct volume (TTC staining) were measured at 24 h. DHC (1.25 mg/kg) produced a stable drop in T(core) (33°C) in naive and I/R mouse models but not in TRPV1 KO mice. DHC (1.25 mg/kg) had no measurable effect on HR and cerebral perfusion but produced a slight transient drop in MAP (<6 mmHg). In stroke mice, DHC infusion produced hypothermia, decreased infarct volume by 87%, and improved neurofunctional score. The hypothermic and neuroprotective effects of DHC were absent in TRPV1 KO mice or mice maintained normothermic with heat support. PH via TRPV1 agonist appears to be a well-tolerated and effective method for promoting mild hypothermia in the conscious mouse. Furthermore, TRPV1 agonism produces effective hypothermia in I/R mice and significantly improves outcome when initiated 90 min after start of reperfusion.

  7. Self-inducible secretion of glucagon-like peptide-1 (GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival.

    PubMed

    Nakashima, Koji; Shimoda, Masashi; Hamamoto, Sumiko; Tatsumi, Fuminori; Hirukawa, Hidenori; Tawaramoto, Kazuhito; Kanda, Yukiko; Kaku, Kohei

    2012-02-26

    Based on the hypothesis that MIN6 cells could produce glucagon-like peptide-1 (GLP-1) to maintain cell survival, we analyzed the effects of GLP-1 receptor agonist, exendin-4 (Ex4), and antagonist, exendin-(9-39) (Ex9) on cell function and cell differentiation. MIN6 cells expressed proglucagon mRNAs and produced GLP-1, which was accelerated by Ex4 and suppressed by Ex9. Moreover, Ex4 further enhanced glucose-stimulated GLP-1 secretion, suggesting autocrine loop-contributed amplification of the GLP-1 signal. Ex4 up-regulated cell differentiation- and cell function-related CREBBP, Pdx-1, Pax6, proglucagon, and PC1/3 gene expressions. The confocal laser scanning images revealed that GLP-1 positive cells were dominant in the early stage of cells, but positive for insulin were more prominent in the mature stage of cells. Ex4 accelerated cell viability, while Ex9 and anti-GLP-1 receptor antibody enhanced cell apoptosis. MIN6 cells possess a mechanism of GLP-1 signal amplification in an autocrine fashion, by which the cells maintained insulin production and cell survival.

  8. Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca(2+) Channels in MIN6 β-Cells.

    PubMed

    Leech, Colin A; Kopp, Richard F; Nelson, Heather A; Nandi, Jyotirmoy; Roe, Michael W

    2017-02-10

    Stromal interaction molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE) and other ion channels either as an endoplasmic reticulum Ca(2+)-sensing protein or when present in the plasma membrane. However, the role of STIM1 in insulin-secreting β-cells is unresolved. We report that lowering expression of STIM1, the gene that encodes STIM1, in insulin-secreting MIN6 β-cells with RNA interference inhibits SOCE and ATP-sensitive K(+) (KATP) channel activation. The effects of STIM1 knockdown were reversed by transduction of MIN6 cells with an adenovirus gene shuttle vector that expressed human STIM1 Immunoprecipitation studies revealed that STIM1 binds to nucleotide binding fold-1 (NBF1) of the sulfonylurea receptor 1 (SUR1) subunit of the KATP channel. Binding of STIM1 to SUR1 was enhanced by poly-lysine. Our data indicate that SOCE and KATP channel activity are regulated by STIM1. This suggests that STIM1 is a multifunctional signaling effector that participates in the control of membrane excitability and Ca(2+) signaling events in β-cells.

  9. Joint min-max distribution and Edwards-Anderson's order parameter of the circular 1/f-noise model

    NASA Astrophysics Data System (ADS)

    Cao, Xiangyu; Le Doussal, Pierre

    2016-05-01

    We calculate the joint min-max distribution and the Edwards-Anderson's order parameter for the circular model of 1/f-noise. Both quantities, as well as generalisations, are obtained exactly by combining the freezing-duality conjecture and Jack-polynomial techniques. Numerical checks come with significantly improved control of finite-size effects in the glassy phase, and the results convincingly validate the freezing-duality conjecture. Application to diffusive dynamics is discussed. We also provide a formula for the pre-factor ratio of the joint/marginal Carpentier-Le Doussal tail for minimum/maximum which applies to any logarithmic random energy model.

  10. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating.

    PubMed

    Lewis, Anthony; McCrossan, Zoe A; Abbott, Geoffrey W

    2004-02-27

    High frequency firing in mammalian neurons requires ultra-rapid delayed rectifier potassium currents generated by homomeric or heteromeric assemblies of Kv3.1 and Kv3.2 potassium channel alpha subunits. Kv3.1 alpha subunits can also form slower activating channels by coassembling with MinK-related peptide 2 (MiRP2), a single transmembrane domain potassium channel ancillary subunit. Here, using channel subunits cloned from rat and expressed in Chinese hamster ovary cells, we show that modulation by MinK, MiRP1, and MiRP2 is a general mechanism for slowing of Kv3.1 and Kv3.2 channel activation and deactivation and acceleration of inactivation, creating a functionally diverse range of channel complexes. MiRP1 also negatively shifts the voltage dependence of Kv3.1 and Kv3.2 channel activation. Furthermore, MinK, MiRP1, and MiRP2 each form channels with Kv3.1-Kv3.2 heteromers that are kinetically distinct from one another and from MiRP/homomeric Kv3 channels. The findings illustrate a mechanism for dynamic expansion of the functional repertoire of Kv3.1 and Kv3.2 potassium currents and suggest roles for these alpha subunits outside the scope of sustained rapid neuronal firing.

  11. Statistical properties of superflares on solar-type stars based on the Kepler 1-min cadence data

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Shibayama, Takuya; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    We searched for superflares on solar-type stars using the Kepler short-cadence (1-min sampling) data in order to detect superflares with short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of 1032 erg to 1036 erg. Using these new data combined with the results from the data with 30-min sampling, we found the occurrence frequency (dN/dE) of superflares as a function of flare energy (E) shows the power-law distribution (dN/dE ~ E -α) with α=1.5 for 1033 < E < 1036 erg. The upper limit of energy released by superflares is basically comparable to a fraction of the magnetic energy stored near starspots which is estimated from the amplitude of brightness variations. We also found that the duration of superflares (τ) increases with the flare energy (E) as τ ~ E 0.39+/-0.03. This can be explained if we assume the time-scale of flares is determined by the Alfvén time.

  12. Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling.

    PubMed

    Chen, Wen-Jia; Wang, Lin-Xi; Wang, Yan-Ping; Chen, Zhou; Liu, Xiao-Ying; Liu, Xiao-Hong; Liu, Li-Bin

    2012-01-01

    Objectives. This study aimed to explore the effect of exendin-4 on t-BHP-induced apoptosis in pancreatic β cells and the mechanism of action. Methods. Murine MIN6 pancreatic β cells were treated with exendin-4 in the presence or absence of tert-butyl hydroperoxide (t-BHP). Cell survival was assessed by MTT staining. The percentage of apoptotic cells was determined by fluorescence microscopy analysis after Hoechst/PI staining and flow cytometric assay after Annexin V-FITC/PI staining. The activity of caspase-3 was determined using a caspase-3 activity kit. Expression of P-IRE1α, IRE1α, C-Jun N-terminal kinase (JNK), P-JNK, C-JUN, and P-C-JUN was detected by western blotting. Results. Exendin-4 was found to inhibit t-BHP-induced apoptosis in pancreatic β-cells by downregulating caspase-3 activity. Exendin-4 also inhibited the endoplasmic reticulum transmembrane protein IRE1, the apoptosis-related signaling molecule JNK, and c-Jun activation. Conclusions. Our findings suggest that exendin-4 ultimately reduces t-BHP-induced β-cell apoptosis. IRE1-JNK-c-Jun signaling is involved in the exendin-4-mediated modulation of β-cell apoptosis.

  13. Excited states in 168Yb from electron-capture decay of 168Lum (T1/2=6.7 min)

    NASA Astrophysics Data System (ADS)

    Barci, V.; Ardisson, G.; Trubert, D.; Hussonnois, M.

    1999-08-01

    The electron-capture decay of the 168Lum (T1/2=6.7 min, Jπ=3+) isomer was studied with high purity sources, obtained by using a new radiochemical method consisting of fast continous on-line separation of reaction products. A complex spectrum composed of about 200 γ rays was observed. From these, 162 transitions were assigned to a level scheme of 39 excited levels of 168Yb, primarily by γ-γ coincidence spectroscopic measurements. About 60 transitions were placed for the first time and >90% of the decay intensity was clearly identified. The structure of the levels directly fed by the electron-capture decay was reviewed as particle-hole excitations of the core.

  14. Uncertainty analysis of gas flow measurements using clearance-sealed piston provers in the range from 0.0012 g min-1 to 60 g min-1

    NASA Astrophysics Data System (ADS)

    Bobovnik, G.; Kutin, J.; Bajsić, I.

    2016-08-01

    This paper deals with an uncertainty analysis of gas flow measurements using a compact, high-speed, clearance-sealed realization of a piston prover. A detailed methodology for the uncertainty analysis, covering the components due to the gas density, dimensional and time measurements, the leakage flow, the density correction factor and the repeatability, is presented. The paper also deals with the selection of the isothermal and adiabatic measurement models, the treatment of the leakage flow and discusses the need for averaging multiple consecutive readings of the piston prover. The analysis is prepared for the flow range (50 000:1) covered by the three interchangeable flow cells. The results show that using the adiabatic measurement model and averaging the multiple readings, the estimated expanded measurement uncertainty of the gas mass flow rate is less than 0.15% in the flow range above 0.012 g min-1, whereas it increases for lower mass flow rates due to the leakage flow related effects. At the upper end of the measuring range, using the adiabatic instead of the isothermal measurement model, as well as averaging multiple readings, proves important.

  15. Statistical properties of superflares on solar-type stars based on the Kepler 1-min cadence data

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Shibayama, Takuya; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    2015-08-01

    We searched for superflares on solar-type stars using the Kepler short-cadence (1-min sampling) data in order to detect superflares with short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of 1032 erg to 1036 erg. Some superflares show multiple peaks with the peak separation of the order of 100-1000 seconds which is comparable to the periods of quasi-periodic pulsations in solar and stellar flares. Using these new data combined with the results from the data with 30 min sampling, we found the occurrence frequency (dN/dE) of superflares as a function of flare energy (E) shows the power-law distribution (dN/dE ∝ E-α) with α=1.5 for 1033

  16. Characterization of the MUC1.Tg/MIN Transgenic Mouse as a Model for Studying Antigen-Specific Immunotherapy of Adenomas

    PubMed Central

    Akporiaye, Emmanuel T.; Bradley-Dunlop, Deborah; Gendler, Sandra J.; Mukherjee, Pinku; Madsen, Cathy S.; Hahn, Tobias; Besselsen, David G.; Dial, Sharon M.; Cui, Haiyan; Trevor, Katrina

    2007-01-01

    A bigenic MUC1.Tg/MIN mouse model was developed by crossing Apc/MIN/+ (MIN) mice with human MUC1 transgenic mice to evaluate MUC1 antigen-specific immunotherapy of intestinal adenomas. The MUC1.Tg/MIN mice developed adenomas at a rate comparable to that of MIN mice and had similar levels of serum MUC1 antigen. A MUC1-based vaccine consisting of MHC class I-restricted MUC1 peptides, a MHC class II-restricted pan-helper peptide, unmethylated CpG oligodeoxynucleotide and GM-CSF caused flattening of adenomas and significantly reduced the number of large adenomas. Immunization was successful in generating a MUC1-directed immune response evidenced by increased MUC1 peptide-specific anti-tumor cytotoxicity and IFN-γ secretion by lymphocytes. PMID:17707958

  17. Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6).

    PubMed Central

    Guillemain, Ghislaine; Da Silva Xavier, Gabriela; Rafiq, Imran; Leturque, Armelle; Rutter, Guy A

    2004-01-01

    The transcription factor PDX-1 (pancreatic and duodenal homeobox-1) is essential for pancreatic development and the maintainence of expression of islet beta-cell-specific genes. In an previous study [Rafiq, Kennedy and Rutter (1998) J. Biol. Chem. 273, 23241-23247] we demonstrated that PDX-1 may be activated at elevated glucose concentrations by translocation from undefined binding sites in the cytosol and nuclear membrane into the nucleoplasm. In the present study, we show that PDX-1 interacts directly and specifically in vitro with the nuclear import receptor family member, importin beta1, and that this interaction is mediated by the PDX-1 homeodomain (amino acids 146-206). Demonstrating the functional importance of the PDX-1-importin beta1 interaction, microinjection of MIN6 beta-cells with anti-(importin beta1) antibodies blocked both the nuclear translocation of PDX-1, and the activation by glucose (30 mM versus 3 mM) of the pre-proinsulin promoter. However, treatment with extracts from pancreatic islets incubated at either low or high glucose concentrations had no impact on the ability of PDX-1 to interact with importin beta1 in vitro. Furthermore, importin beta1 also interacted with SREBP1c (sterol-regulatory-element-binding protein 1c) in vitro, and microinjection of importin beta1 antibodies blocked the activation by glucose of SREBP1c target genes. Since the subcellular distribution of SREBP1c is unaffected by glucose, these findings suggest that a redistribution of importin beta1 is unlikely to explain the glucose-stimulated nuclear uptake of PDX-1. Instead, we conclude that the uptake of PDX-1 into the nucleoplasm, as glucose concentrations increase, may be mediated by release of the factor both from sites of retention in the cytosol and from non-productive complexes with importin beta1 at the nuclear membrane. PMID:14632628

  18. Comparison of 1-min rain rate derived from TRMM satellite data and raingauge data for microwave applications in Nigeria

    NASA Astrophysics Data System (ADS)

    Ojo, J. S.; Omotosho, T. V.

    2013-09-01

    A comparative statistical study of derived 1-min rain rate using data obtained from Tropical Rainfall Measuring Mission (TRMM) satellite (3A12 V6 and 3B43V6) and raingauge measurements are presented. 30-years data of rainfall intensities obtained from the Nigerian Meteorological Agency rain-gauge network and 9-years rainfall data obtained from TRMM satellite are used. Cumulative distributions of rain rate were obtained using a combination of an improved version of the Moupfouma-Martin model for rain rate prediction in the tropical regions. Variations of rain rate of different integration time are compared for 28 stations across Nigeria. The Kriging interpolation method was used for spatial interpolation of rain accumulation values into a regular grid in order to obtain a highly consistent and predictable inter-gauge rainfall variation. Noticeable differences between rain rate estimated from rain-gauge and TRMM data were found to be a function of period and location. From quantitative comparison over each of the region, there are reasonably positive correlations between the two sets of data for different percentages of time with correlation coefficient varying from 0.84 to 0.99 at 99.99% availability of time. Comparison with ITU-R 837-5 shows that, ITU model underestimates rain rate as high as 51% from the mean value depending on the percentages of at which time rain rate is exceeded. The overall result shows that the gauge data perform better than TRMM data in most of the sites located in the SW, SE, SS, MB and NE regions, while TRMM data provided better results for sites in the NW region from the statistical perspective with the lower RMS values.

  19. Thermal adaptation of the crucian carp (Carassius carassius) cardiac delayed rectifier current, IKs, by homomeric assembly of Kv7.1 subunits without MinK.

    PubMed

    Hassinen, Minna; Laulaja, Salla; Paajanen, Vesa; Haverinen, Jaakko; Vornanen, Matti

    2011-07-01

    Ectothermic vertebrates experience acute and chronic temperature changes which affect cardiac excitability and may threaten electrical stability of the heart. Nevertheless, ectothermic hearts function over wide range of temperatures without cardiac arrhythmias, probably due to special molecular adaptations. We examine function and molecular basis of the slow delayed rectifier K(+) current (I(Ks)) in cardiac myocytes of a eurythermic fish (Carassius carassius L.). I(Ks) is an important repolarizing current that prevents excessive prolongation of cardiac action potential, but it is extremely slowly activating when expressed in typical molecular composition of the endothermic animals. Comparison of the I(Ks) of the crucian carp atrial myocytes with the currents produced by homomeric K(v)7.1 and heteromeric K(v)7.1/MinK channels in Chinese hamster ovary cells indicates that activation kinetics and pharmacological properties of the I(Ks) are similar to those of the homomeric K(v)7.1 channels. Consistently with electrophysiological properties and homomeric K(v)7.1 channel composition, atrial transcript expression of the MinK subunit is only 1.6-1.9% of the expression level of the K(v)7.1 subunit. Since activation kinetics of the homomeric K(v)7.1 channels is much faster than activation of the heteromeric K(v)7.1/MinK channels, the homomeric K(v)7.1 composition of the crucian carp cardiac I(Ks) is thermally adaptive: the slow delayed rectifier channels can open despite low body temperatures and curtail the duration of cardiac action potential in ectothermic crucian carp. We suggest that the homomeric K(v)7.1 channel assembly is an evolutionary thermal adaptation of ectothermic hearts and the heteromeric K(v)7.1/MinK channels evolved later to adapt I(Ks) to high body temperature of endotherms.

  20. Critical power derived from a 3-min all-out test predicts 16.1-km road time-trial performance.

    PubMed

    Black, Matthew I; Durant, Jacob; Jones, Andrew M; Vanhatalo, Anni

    2014-01-01

    It has been shown that the critical power (CP) in cycling estimated using a novel 3-min all-out protocol is reliable and closely matches the CP derived from conventional procedures. The purpose of this study was to assess the predictive validity of the all-out test CP estimate. We hypothesised that the all-out test CP would be significantly correlated with 16.1-km road time-trial (TT) performance and more strongly correlated with performance than the gas exchange threshold (GET), respiratory compensation point (RCP) and VO2 max. Ten club-level male cyclists (mean±SD: age 33.8±8.2 y, body mass 73.8±4.3 kg, VO2 max 60±4 ml·kg(-1min(-1)) performed a 10-mile road TT, a ramp incremental test to exhaustion, and two 3-min all-out tests, the first of which served as familiarisation. The 16.1-km TT performance (27.1±1.2 min) was significantly correlated with the CP (309±34 W; r = -0.83, P<0.01) and total work done during the all-out test (70.9±6.5 kJ; r = -0.86, P<0.01), the ramp incremental test peak power (433±30 W; r = -0.75, P<0.05) and the RCP (315±29 W; r = -0.68, P<0.05), but not with GET (151±32 W; r = -0.21) or the VO2 max (4.41±0.25 L·min(-1); r = -0.60). These data provide evidence for the predictive validity and practical performance relevance of the 3-min all-out test. The 3-min all-out test CP may represent a useful addition to the battery of tests employed by applied sport physiologists or coaches to track fitness and predict performance in atheletes.

  1. Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways.

    PubMed

    Hao, Feng; Kang, Jinsen; Cao, Yajun; Fan, Shengjun; Yang, Haopeng; An, Yu; Pan, Yan; Tie, Lu; Li, Xuejun

    2015-11-01

    Lipotoxicity plays a vital role in development and progression of type 2 diabetes. Prolonged elevation of free fatty acids especially the palmitate leads to pancreatic β-cell dysfunction and apoptosis. Curcumin (diferuloylmethane), a polyphenol from the curry spice turmeric, is considered to be a broadly cytoprotective agent. The present study was designed to determine the protective effect of curcumin on palmitate-induced apoptosis in β-cells and investigate underlying mechanisms. Our results showed that curcumin improved cell viability and enhanced glucose-induced insulin secretory function in MIN6 pancreatic β-cells. Palmitate incubation evoked chromatin condensation, DNA nick end labeling and activation of caspase-3 and -9. Curcumin treatment inhibited palmitate-induced apoptosis, relieved mitochondrial depolarization and up-regulated Bcl-2/Bax ratio. Palmitate induced the generation of reactive oxygen species and inhibited activities of antioxidant enzymes, which could be neutralized by curcumin treatment. Moreover, curcumin could promote rapid phosphorylation of Akt and nuclear exclusion of FoxO1 in MIN6 cells under lipotoxic condition. Phosphatidylinositol 3-kinase and Akt specific inhibitors abolished the anti-lipotoxic effect of curcumin and stimulated FoxO1 nuclear translocation. These findings suggested that curcumin protected MIN6 pancreatic β-Cells against apoptosis through activation of Akt, inhibition of nuclear translocation of FoxO1 and mitochondrial survival pathway.

  2. Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer.

    PubMed

    Zhang, Ning; Subbaramaiah, Kotha; Yantiss, Rhonda K; Zhou, Xi Kathy; Chin, Yvette; Benezra, Robert; Dannenberg, Andrew J

    2015-04-01

    Different mechanisms contribute to the development of sporadic, hereditary and colitis-associated colorectal cancer. Inhibitor of DNA binding/differentiation (Id) proteins act as dominant-negative antagonists of basic helix-loop-helix transcription factors. Id1 is a promising target for cancer therapy, but little is known about its role in the development of colon cancer. We used immunohistochemistry to demonstrate that Id1 is overexpressed in human colorectal adenomas and carcinomas, whether sporadic or syndromic. Furthermore, elevated Id1 levels were found in dysplasia and colon cancer arising in patients with inflammatory bowel disease. Because levels of PGE2 are also elevated in both colitis and colorectal neoplasia, we determined whether PGE2 could induce Id1. PGE2 via EP4 stimulated protein kinase A activity resulting in enhanced pCREB-mediated Id1 transcription in human colonocytes. To determine the role of Id1 in carcinogenesis, two mouse models were used. Consistent with the findings in humans, Id1 was overexpressed in tumors arising in both Apc(Min) (/+) mice, a model of familial adenomatous polyposis, and in experimental colitis-associated colorectal neoplasia. Id1 deficiency led to significant decrease in the number of intestinal tumors in Apc(Min) (/+) mice and prolonged survival. In contrast, Id1 deficiency did not affect the number or size of tumors in the model of colitis-associated colorectal neoplasia, likely due to exacerbation of colitis associated with Id1 loss. Collectively, these results suggest that Id1 plays a role in gastrointestinal carcinogenesis. Our findings also highlight the need for different strategies to reduce the risk of colitis-associated colorectal cancer compared with sporadic or hereditary colorectal cancer.

  3. Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc(Min/+) Mice, Correlating with CB1 Receptor Up-Regulation.

    PubMed

    Notarnicola, Maria; Tutino, Valeria; De Nunzio, Valentina; Dituri, Francesco; Caruso, Maria Gabriella; Giannelli, Gianluigi

    2017-02-24

    Mediterranean diet components, such as olive oil and ω-3 polyunsaturated fatty acids (ω-3 PUFAs), can arrest cell growth and promote cell apoptosis. Recently, olive oil has been demonstrated to modulate type-1 cannabinoid (CB1) receptor gene expression in both human colon cancer cells and rat colon. The aim of this study was to investigate a possible link between olive oil and ω-3 PUFAs effects and CB1 receptor expression in both intestinal and adipose tissue of Apc(Min/+) mice. To confirm the role for the CB1 receptor as a negative modulator of cell proliferation in human colon cancer, CB1 receptor gene expression was also detected in tumor tissue and in surrounding normal mucosa of patients with colorectal cancer (CRC). Dietary ω-3 PUFAs significantly inhibited intestinal polyp growth in mice, correlating with CB1 receptor gene and protein expression induction. CB1 receptor gene up-regulation was also detected in adipose tissue, suggesting a close communication between cancer cells and the surrounding environment. Tissue CB1 receptor induction was associated with a concurrent inactivation of the Wnt/β-catenin pathway. Moreover, there was a significant reduction in CB1 receptor gene expression levels in cancer tissue compared to normal surrounding mucosa of patients with CRC, confirming that in cancer the "protective" action of the CB1 receptor is lost.

  4. Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic ApcMin/+ Mice, Correlating with CB1 Receptor Up-Regulation

    PubMed Central

    Notarnicola, Maria; Tutino, Valeria; De Nunzio, Valentina; Dituri, Francesco; Caruso, Maria Gabriella; Giannelli, Gianluigi

    2017-01-01

    Mediterranean diet components, such as olive oil and ω-3 polyunsaturated fatty acids (ω-3 PUFAs), can arrest cell growth and promote cell apoptosis. Recently, olive oil has been demonstrated to modulate type-1 cannabinoid (CB1) receptor gene expression in both human colon cancer cells and rat colon. The aim of this study was to investigate a possible link between olive oil and ω-3 PUFAs effects and CB1 receptor expression in both intestinal and adipose tissue of ApcMin/+ mice. To confirm the role for the CB1 receptor as a negative modulator of cell proliferation in human colon cancer, CB1 receptor gene expression was also detected in tumor tissue and in surrounding normal mucosa of patients with colorectal cancer (CRC). Dietary ω-3 PUFAs significantly inhibited intestinal polyp growth in mice, correlating with CB1 receptor gene and protein expression induction. CB1 receptor gene up-regulation was also detected in adipose tissue, suggesting a close communication between cancer cells and the surrounding environment. Tissue CB1 receptor induction was associated with a concurrent inactivation of the Wnt/β-catenin pathway. Moreover, there was a significant reduction in CB1 receptor gene expression levels in cancer tissue compared to normal surrounding mucosa of patients with CRC, confirming that in cancer the “protective” action of the CB1 receptor is lost. PMID:28245562

  5. Flow modulation comprehensive two-dimensional gas chromatography-mass spectrometry using ≈4 mL min(-1) gas flows.

    PubMed

    Franchina, Flavio A; Maimone, Mariarosa; Tranchida, Peter Q; Mondello, Luigi

    2016-04-08

    The main objective of the herein described research was focused on performing satisfactory flow modulation (FM), in comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS), using an MS-compatible second-dimension gas flow of approx. 4 mL min(-1). The FM model used was based on that initially proposed by Seeley et al. [3]. The use of limited gas flows was enabled through fine tuning of the FM parameters, in particular the duration of the re-injection (or flushing) process. Specifically, the application of a long re-injection period (i.e., 700 ms) enabled efficient accumulation-loop flushing with gas flows of about 4 mL min(-1). It was possible to apply such extended re-injection periods by using different restrictor lengths in the connections linking the modulator to the auxiliary pressure source. FM GC×GC-MS applications were performed on a mixture containing C9-10 alkanes, and on a sample of essential oil. GC×GC-MS sensitivity was compared with that attained by using conventional GC-MS analysis, in essential oil applications. It was observed that signal intensities were, in general, considerably higher in the FM GC×GC-MS experiments.

  6. Excited states in the doubly odd 168Lu nucleus fed by electron-capture decay of 168Hf (T1/2=25.95 min)

    NASA Astrophysics Data System (ADS)

    Barci, V.; Ardisson, G.; Trubert, D.; Hussonnois, M.

    1997-05-01

    The low-spin levels of the odd-odd nucleus 168Lu from 168Hf (T1/2=25.95 min) electron-capture decay were investigated by direct γ and γ-γ coincidence measurements. The sources of 168Hf were produced with the 156Gd(16O,4n) reaction and radiochemically separated using chromatographic methods. A level scheme of 39 new levels in the 168Lu nucleus was proposed, accounting for 107 of 119 observed γ transitions assigned to 168Hf electron-capture decay. Transition multipolarities, level-spins, and parities were deduced or proposed. A tentative decay scheme was proposed. Level structure was discussed in the framework of the particle-rotor and Nilsson models.

  7. Earth2014: 1 arc-min shape, topography, bedrock and ice-sheet models - Available as gridded data and degree-10,800 spherical harmonics

    NASA Astrophysics Data System (ADS)

    Hirt, Christian; Rexer, Moritz

    2015-07-01

    Since the release of the ETOPO1 global Earth topography model through the US NOAA in 2009, new or significantly improved topographic data sets have become available over Antarctica, Greenland and parts of the oceans. Here, we present a suite of new 1‧ (arc-min) models of Earth's topography, bedrock and ice-sheets constructed as a composite from up-to-date topography models: Earth2014. Our model suite relies on SRTM30_PLUS v9 bathymetry for the base layer, merged with SRTM v4.1 topography over the continents, Bedmap2 over Antarctica and the new Greenland bedrock topography (GBT v3). As such, Earth2014 provides substantially improved information of bedrock and topography over Earth's major ice sheets, and more recent bathymetric depth data over the oceans, all merged into readily usable global grids. To satisfy multiple applications of global elevation data, Earth2014 provides different representations of Earth's relief. These are grids of (1) the physical surface, (2) bedrock (Earth's relief without water and ice masses), (3) bedrock and ice (Earth without water masses), (4) ice sheet thicknesses, (5) rock-equivalent topography (ice and water masses condensed to layers of rock) as mass representation. These models have been transformed into ultra-high degree spherical harmonics, yielding degree 10,800 series expansions of the Earth2014 grids as input for spectral modelling techniques. As further variants, planetary shape models were constructed, providing distances between relief points and the geocenter. The paper describes the input data sets, the development procedures applied, the resulting gridded and spectral representations of Earth2014, external validation results and possible applications. The Earth2014 model suite is freely available via http://ddfe.curtin.edu.au/models/Earth2014/.

  8. Generalized min-max bound-based MRI pulse sequence design framework for wide-range T1 relaxometry: A case study on the tissue specific imaging sequence

    PubMed Central

    Buck, John R.; Ikonomidou, Vasiliki N.

    2017-01-01

    This paper proposes a new design strategy for optimizing MRI pulse sequences for T1 relaxometry. The design strategy optimizes the pulse sequence parameters to minimize the maximum variance of unbiased T1 estimates over a range of T1 values using the Cramér-Rao bound. In contrast to prior sequences optimized for a single nominal T1 value, the optimized sequence using our bound-based strategy achieves improved precision and accuracy for a broad range of T1 estimates within a clinically feasible scan time. The optimization combines the downhill simplex method with a simulated annealing process. To show the effectiveness of the proposed strategy, we optimize the tissue specific imaging (TSI) sequence. Preliminary Monte Carlo simulations demonstrate that the optimized TSI sequence yields improved precision and accuracy over the popular driven-equilibrium single-pulse observation of T1 (DESPOT1) approach for normal brain tissues (estimated T1 700–2000 ms at 3.0T). The relative mean estimation error (MSE) for T1 estimation is less than 1.7% using the optimized TSI sequence, as opposed to less than 7.0% using DESPOT1 for normal brain tissues. The optimized TSI sequence achieves good stability by keeping the MSE under 7.0% over larger T1 values corresponding to different lesion tissues and the cerebrospinal fluid (up to 5000 ms). The T1 estimation accuracy using the new pulse sequence also shows improvement, which is more pronounced in low SNR scenarios. PMID:28222197

  9. Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.

    PubMed

    Svendsen, Camilla; Meinl, Walter; Glatt, Hansruedi; Alexander, Jan; Knutsen, Helle K; Hjertholm, Hege; Rasmussen, Tone; Husøy, Trine

    2012-12-01

    Humans express sulfotransferases (SULTs) of the SULT1A subfamily in many tissues, whilst the single SULT1A gene present in rodents is mainly expressed in liver. The food processing contaminants, 5-hydroxymethylfurfural (HMF) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), are bioactivated by human SULT1A1 and SULT1A2. FVB multiple intestinal neoplasia (Min) mice, which spontaneously develop tumors and flat aberrant crypt foci (ACF) in intestine, were crossed with transgenic FVB mice expressing human SULT1A1 and 1A2 (hSULT) in several tissues, giving rise to wild-type and Min mice with and without hSULT. One-week-old Min mice with or without hSULT were given HMF (375 or 750 mg/kg bw) or saline by gavage three times a week for 11 wk. In another experiment, the F1 generation received subcutaneous injections of 50 mg/kg bw PhIP or saline 1 wk before birth, and 1, 2, and 3 wk after birth. HMF did not affect the formation of tumors, but may have induced some flat ACF (incidence 15-20%) in Min mice with and without hSULT. No control mouse developed any flat ACF. With the limitation that these putative effects were weak, they were unaffected by hSULT expression. The carcinogenic effect of PhIP increased in the presence of hSULT, with a significant increase in both incidence (31-80%) and number of colonic tumors (0.4-1.3 per animal). Thus, intestinal expression of human SULT1A1 and 1A2 might increase the susceptibility to compounds bioactivated via this pathway implying that humans might be more susceptible than conventional rodent models.

  10. Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes

    PubMed Central

    Herlyn, Holger; Zechner, Ulrich; Oswald, Franz; Pfeufer, Arne; Zischler, Hans; Haaf, Thomas

    2009-01-01

    Background KCNE1 represents the regulatory beta-subunit of the slowly activating delayed rectifier potassium channel (IKs). Variants of KCNE1 have repeatedly been linked to the long-QT syndrome (LQTS), a disorder which predisposes to deafness, ventricular tachyarrhythmia, syncope, and sudden cardiac death. Results We here analyze the evolution of the common Gly38Ser variant (rs1805127), using genomic DNAs, complementary DNAs, and HEK293-expressed variants of altogether 19 mammalian species. The between species comparison reveals that the human-specific Gly38Ser polymorphism evolved under strong positive Darwinian selection, probably in adaptation to specific challenges in the fine-tuning of IKs channels. The involved amino acid exchanges (Asp > Gly, Gly > Ser) are moderately radical and do not induce apparent changes in posttranslational modification. According to population genetic analyses (HapMap phase II) a heterozygote advantage accounts for the maintenance of the Gly38Ser polymorphism in humans. On the other hand, the expression of the 38Ser allele seems to be disadvantageous under certain conditions, as suggested by the sporadic deficiency of 38Ser-coding mRNAs in heterozygote Central Europeans and the depletion of homozygotes 38Ser in the Yoruban sample. Conclusion We speculate that individual differences in genomic imprinting or genomic recoding might have contributed to conflicting results of recent association studies between Gly38Ser polymorphism and QT phenotype. The findings thus highlight the relevance of mRNA data in future association studies of genotypes and clinical disorders. To the best of our knowledge, they moreover provide first time evidence for a unique pattern; i.e. coincidence of positive Darwinian selection and polymorphism with a sporadically suppressed expression of one allele. PMID:19660109

  11. 1,1,1-Trichloroethane

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 03 / 013 www.epa.gov / iris TOXICOLOGICAL REVIEW OF 1,1,1 - TRICHLOROETHANE ( CAS No . 71 - 55 - 6 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) August 2007 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has bee

  12. MI1AENG1

    Atmospheric Science Data Center

    2014-09-03

    MI1AENG1 MISR Level 1A Engineering Data File Type 1: Reformatted Annotated Level 1A product for the camera engineering data, which represents indicators of sampled measurements. ... Status Production Report Read Software Files :  Data Product Specification Versioning ...

  13. SSCA1-K1

    SciTech Connect

    Baker, Matthew

    2015-11-06

    SSCA1-K1 is a parallel implementation of kernel 1 of the SSCA1 benchmark suite released by the DARPA HPCS program. This kernel is able to run in parallel on a distributed shared memory system at extreme scales using OpenSHMEM.

  14. 1,1-Difluoroethane

    Integrated Risk Information System (IRIS)

    1,1 - Difluoroethane ; CASRN 75 - 37 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogen

  15. 1,1-Dichloroethane

    Integrated Risk Information System (IRIS)

    1,1 - Dichloroethane ; CASRN 75 - 34 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogen

  16. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  17. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  18. Thoughts on Why (-1)(-1) = +1

    ERIC Educational Resources Information Center

    Rapke, Tina

    2008-01-01

    This article considers why (-1)(-1) = +1 and how and why a teacher might go about explaining this concept to high school students without using pseudoreasoning. Furthermore, it provides a precise explanation, through the use of the distributive property, as to why (-1)(-1) = +1. (Contains 1 figure.)

  19. Hawking's A Briefer History of Time's No-God-Universe disproven by primordial ^218Po halos embedded in granite rocks, which proves their rapid creation due to ^218Po's 3 min t1/2, something only the God of Genesis could have done

    NASA Astrophysics Data System (ADS)

    Gentry, Robert

    2011-04-01

    Quotes from my Science (184, 62, 1974) report, Radiohalos in Radiochronological and Cosmological Perspective, show why primordial polonium halos earlier commanded attention for creation," It is also apparent that Po halos do pose contradictions to currently held views of Earth history" "For example, there is first the problem of how isotopic separation of several Po isotopes [or their β-decay precursors could have occurred naturally. Second, a straightforward explanation of ^218Po halos implies that the 1-μm radiocenters of very dark halos of this type initially contained as many as 5 x 10^9 atoms (a concentration of more than 50 percent) of the isotope ^218Po (half-life, 3 minutes), a problem that almost defies reason. A further necessary consequence, that such Po halos could have formed only if the host rocks underwent a rapid crystallization, renders exceedingly difficult, in my estimation, the prospect of explaining these halos by physical laws as presently understood." In 1977 E. P. Wigner, G. N. Flerov (Dubna), Ed Anders, E. Segre, F. Dyson, and John Wheeler all commented on these results (see alphacosmos.net). Also, ^14N detection in dwarf radiohalos may be of cosmological significance in implying a superheavy element origin from ^14C emission.

  20. 1,1,1,2-Tetrafluoroethane

    Integrated Risk Information System (IRIS)

    1,1,1,2 - Tetrafluoroethane ; CASRN 811 - 97 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonca

  1. 1,1,1,2-Tetrachloroethane

    Integrated Risk Information System (IRIS)

    1,1,1,2 - Tetrachloroethane ; CASRN 630 - 20 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonca

  2. 1-Chloro-1,1-difluoroethane

    Integrated Risk Information System (IRIS)

    1 - Chloro - 1,1 - difluoroethane ; CASRN 75 - 68 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for

  3. MinC/MinD copolymers are not required for Min function.

    PubMed

    Park, Kyung-Tae; Du, Shishen; Lutkenhaus, Joe

    2015-12-01

    In Escherichia coli, precise placement of the cytokinetic Z ring at midcell requires the concerted action of the three Min proteins. MinD activates MinC, an inhibitor of FtsZ, at least in part, by recruiting it to the membrane and targeting it to the Z ring, while MinE stimulates the MinD ATPase inducing an oscillation that directs MinC/MinD activity away from midcell. Recently, MinC and MinD were shown to form copolymers of alternating dimers of MinC and MinD, and it was suggested that these copolymers are the active form of MinC/MinD. Here, we use MinD mutants defective in binding MinC to generate heterodimers with wild-type MinD that are unable to form MinC/MinD copolymers. Similarly, MinC mutants defective in binding to MinD were used to generate heterodimers with wild-type MinC that are unable to form copolymers. Such heterodimers are active and in the case of MinC were shown to mediate spatial regulation of the Z ring demonstrating that MinC/MinD copolymer formation is not required. Our results are consistent with a model in which a membrane anchored MinC/MinD complex is targeted to the Z ring through the conserved carboxy tail of FtsZ leading to breakage of FtsZ filaments.

  4. Transient Pressure Test Article (TPTA) 1.1 and 1.1A, volume 1

    NASA Technical Reports Server (NTRS)

    Rebells, Clarence A.

    1988-01-01

    This final test report presents the results obtained during the static hot firing and cold-gas high Q tests of the first Transient Pressure Test Article (TPTA) 1.1. The TPTA consisted of field test joints A and B, which were the original RSRM J-insulation configuration, with a metal capture feature. It also consisted of a flight configuration nozzle-to-case test joint (Joint D) with shorter vent slots. Fluorocarbon O-rings were used in all the test joints. The purpose of the TPTA tests is to evaluate and characterize the RSMR field and nozzle-to-case joints under the influence of ignition and strut loads during liftoff anf high Q. All objectives of the cold-gas high Q (TPTA 1.1A) test were met and all measurements were close to predicted values. During the static hot-firing test (TPTA 1.1), the motor was inadvertently plugged by the quench injector plug, making it a more severe test, although no strut loads were applied. The motor was depressurized after approximately 11 min using an auxiliary system, and no anomalies were noted. In the static hot-firing test, pressure was incident on the insulation and the test joint gaps were within the predicted range. During the static hot-firing test, no strut loads were applied because the loading system malfunctioned. For this test, all measurements were within range of similar tests performed without strut loads.

  5. TRPV1.

    PubMed

    Bevan, Stuart; Quallo, Talisia; Andersson, David A

    2014-01-01

    TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory neurons involved in pain sensation and also at a number of other neuronal and non-neuronal sites in the mammalian body. Functionally, TRPV1 acts as a sensor for noxious heat (greater than ~42 °C). It can also be activated by some endogenous lipid-derived molecules, acidic solutions (pH < 6.5) and some pungent chemicals and food ingredients such as capsaicin, as well as by toxins such as resiniferatoxin and vanillotoxins. Structurally, TRPV1 subunits have six transmembrane (TM) domains with intracellular N- (containing 6 ankyrin-like repeats) and C-termini and a pore region between TM5 and TM6 containing sites that are important for channel activation and ion selectivity. The N- and C- termini have residues and regions that are sites for phosphorylation/dephosphorylation and PI(4,5)P2 binding, which regulate TRPV1 sensitivity and membrane insertion. The channel has several interacting proteins, some of which (e.g. AKAP79/150) are important for TRPV1 phosphorylation. Four TRPV1 subunits form a non-selective, outwardly rectifying ion channel permeable to monovalent and divalent cations with a single-channel conductance of 50-100 pS. TRPV1 channel kinetics reveal multiple open and closed states, and several models for channel activation by voltage, ligand binding and temperature have been proposed. Studies with TRPV1 agonists and antagonists and Trpv1 (-/-) mice have suggested a role for TRPV1 in pain, thermoregulation and osmoregulation, as well as in cough and overactive bladder. TRPV1 antagonists have advanced to clinical trials where findings of drug-induced hyperthermia and loss of heat sensitivity have raised questions about the viability of this therapeutic approach.

  6. 1,1-Dichloroethylene (1,1-DCE)

    Integrated Risk Information System (IRIS)

    EPA / 635 / R02 / 002 TOXICOLOGICAL REVIEW OF 1,1 - DICHLOROETHYLENE ( CAS No . 75 - 35 - 4 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) June 2002 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has been reviewed in accordance

  7. TRPA1.

    PubMed

    García-Añoveros, J; Nagata, K

    2007-01-01

    The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs. In mice, TRPA1 is almost exclusively expressed in nociceptive neurons of peripheral ganglia and in all the mechanosensory epithelia of inner ear. In nociceptive neurons, TRPA1 mediates the response to the proalgesic bradykinin as well as the response to pungent irritants found in mustards and garlic, and probably also to those found in cinnamon and tear gas. The channel properties of TRPA1 are discussed and compared to those of sensory transducers. TRPA1 is well conserved across the animal kingdom, with likely orthologs from human to nematode, which suggest an ancestral role for this channel, probably in sensation.

  8. Ambra1

    PubMed Central

    Van Humbeeck, Cindy; Cornelissen, Tom

    2011-01-01

    Mutations in the gene for the E3 ubiquitin ligase Parkin are the most prevalent cause of autosomal recessive Parkinson disease (PD), an incurable neurodegenerative disorder. Parkin surveys mitochondrial quality by translocating to depolarized mitochondria and inducing their selective macroautophagic removal (mitophagy). We recently reported that Parkin interacts with Ambra1 (activating molecule in Beclin 1-regulated autophagy), a protein that promotes autophagy in the vertebrate central nervous system. We discovered that prolonged mitochondrial depolarization strongly increases the interaction of Parkin with Ambra1. Ambra1 is recruited in a Parkin-dependent manner to perinuclear clusters of depolarized mitochondria, activates the class III phosphatidylinositol 3-kinase (PtdIns3K) complex around these mitochondria and contributes to their selective autophagic clearance. Here, we discuss these findings and suggest a model where translocated Parkin efficiently triggers mitophagy through combined recruitment of Ambra1 and ubiquitination of outer mitochondrial membrane proteins. PMID:21921694

  9. Neurofibromatosis-1

    MedlinePlus

    ... the same NF1 gene change. "Coffee-with-milk" ( café-au-lait ) spots are the hallmark symptom of ... Many healthy people have one or two small café au lait spots. However, adults who have six ...

  10. 1,1,2-Trichloroethane

    Integrated Risk Information System (IRIS)

    1,1,2 - Trichloroethane ; CASRN 79 - 00 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  11. 1,1,2-Trichloropropane

    Integrated Risk Information System (IRIS)

    1,1,2 - Trichloropropane ; CASRN 598 - 77 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarci

  12. 1/N

    SciTech Connect

    Coleman, S.

    1980-03-01

    There exist families of field theories with symmetry group SO(N) (or SU(N)) that become simpler as N becomes larger. More precisely, the solutions to these theories possess an expansion in powers of 1/N. This expansion is the subject of these lectures. The 1/N expansion can be used to analyze model field theories. The 1/N expansion is developed for phi/sup 4/ theory and applied to two two-dimensional models with similar combinatoric structures, the Gross-Neveu model and the CP/sup N-1/ model. These models display (in the leading 1/N approximation) such interesting phenomena as asymptotic freedom, dynamical symmetry breaking, dimensional transmutation, and non-perturbative confinement. It is possible that the 1/N expansion, with N the number of colors, might fruitfully be applied to quantum chromodynamics. Unfortunately, it is not possible to make a decisive test of the approximation, because no one knows how to compute even the first term in the expansion in closed form. However, it is possible to argue that this first term, whatever its detailed form, has many properties that are also shared by the real world, and which are otherwise underived from field theory. These include the saturation of scattering amplitudes by an infinite number of narrow resonances, the essential feature of dual-resonance models. (RWR)

  13. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  14. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  15. Min-Max Bias Robust Regression.

    DTIC Science & Technology

    1987-08-01

    2 UL uIImImmIIIEllmlllllllll llEllllhllllEI El 1 .1 25 11111 -.4 ___ . .. . . N ~ . MIN- MAX BIAS ROBUST REGRESSION by R. D. Martin V. J. Yohai R. H...shown than an S-estimate based on a jump-function type p solves the n- max bias problem for the class of NI-estimates with very general scale. This...5, (X() -- .5 and the rin- max estimator approaches the least median of squared residuals estimator introduced by Rousseeuw [J. Am. Statist. Assoc

  16. On Algorithms for Nonlinear Minimax and Min-Max-Min Problems and Their Efficiency

    DTIC Science & Technology

    2011-03-01

    Monterey CA 93943-5000 The views expressed in this thesis are those of the author and do not reflect the official policy or position of the Department of...MINIMAX AND MIN-MAX-MIN PROBLEMS AND THEIR EFFICIENCY Pee Eng Yau Principal Analyst, Singapore Defence Science and Technology Agency B.Eng., National...BLANK xii LIST OF TABLES 1. Run times based on ϵ for ϵ- PPP . The word “local” means that the algorithm converges to a locally optimal solution that does

  17. 1-Chlorobutane

    Integrated Risk Information System (IRIS)

    1 - Chlorobutane ; CASRN 109 - 69 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic

  18. Sirt1

    PubMed Central

    Fusco, Salvatore; Maulucci, Giuseppe; Pani, Giovambattista

    2012-01-01

    Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to “healthspan,” and a decline of Sirt-centered protective circuits over time may explain the “catastrophic” nature of aging. PMID:22983125

  19. Protoexist1

    NASA Astrophysics Data System (ADS)

    Copete, Antonio; Allen, B.; Hong, J.; Grindlay, J.; Gehrels, N.; Barthelmy, S.; Baker, R.; Apple, J.; Benson, C.; Garson, T.; Krawczynski, H.; McLean, R.; Cook, R.

    2009-01-01

    The ProtoEXIST1 mission, a pathfinder for the EXIST high energy telescope (HET), is slated for a spring 2009 flight out of Ft. Sumner, NM. The ProtoEXIST payload consists of two coded aperture telescopes, each with a 10^ 10^deg field of view and an angular resolution of approximately 10'. One telescope will be outfitted with passive Pb/Sn/Cu rear and side shielding while the other will utilize a rear active CsI anti-coincidence shield and passive side shielding for comparison of background rejection efficiency. The detector plane of each telescope consists of a 8 times 8 large tiled array of 2.04 cm times 2.04 cm CZT detectors, each with thickness of 0.5 cm and a pixilated anode consisting of 2.5 mm pixels. Each detector is read out utilizing the Caltech RADNET ASIC. In total the detector plane of a single telescope measures 16 cm times 16 cm and is sensitive over an energy range of 10 keV up to 500 keV, with an energy resolution of 3.1 keV FWHM at 59 keV. The ProtoEXIST1 flight will validate the use of tiled CZT arrays in flight and pave the way for ProtoEXIST2 which will demonstrate the use of a tiled array of CZT detectors with 0.6 mm pixels.

  20. Timing matters: negative emotion elicited 5 min but not 30 min or 45 min after learning enhances consolidation of internal-monitoring source memory.

    PubMed

    Wang, Bo; Bukuan, Sun

    2015-05-01

    Two experiments examined the time-dependent effects of negative emotion on consolidation of item and internal-monitoring source memory. In Experiment 1, participants (n=121) learned a list of words. They were asked to read aloud half of the words and to think about the remaining half. They were instructed to memorize each word and its associative cognitive operation ("reading" versus "thinking"). Immediately following learning they conducted free recall and then watched a 3-min either neutral or negative video clip when 5 min, 30 min or 45 min had elapsed after learning. Twenty-four hours later they returned to take surprise tests for item and source memory. Experiment 2 was similar to Experiment 1 except that participants, without conducting an immediate test of free recall, took tests of source memory for all encoded words both immediately and 24 h after learning. Experiment 1 showed that negative emotion enhanced consolidation of item memory (as measured by retention ratio of free recall) regardless of delay of emotion elicitation and that negative emotion enhanced consolidation of source memory when it was elicited at a 5 min delay but reduced consolidation of source memory when it was elicited at a 30 min delay; when elicited at a 45 min delay, negative emotion had little effect. Furthermore, Experiment 2 replicated the enhancement effect on source memory in the 5 min delay even when participants were tested on all the encoded words. The current study partially replicated prior studies on item memory and extends the literature by providing evidence for a time-dependent effect of negative emotion on consolidation of source memory based on internal monitoring.

  1. SPITFIRE-1

    NASA Technical Reports Server (NTRS)

    Ryntz, Edward F.

    1995-01-01

    The purpose of this effort is to develop low-cost rapid forming superplastic aluminum that will be evaluated in pilot production trials for automotive SPF components. The alloy development study conducted under SPITFIRE-1 showed that the addition of CU or Mn to the base 5083 aluminum alloy refined the grain size, leading to enhanced superplastic properties. In SPITFIRE-2, these alloy variants will be further refined and studied to meet the target properties established earlier in the program. Mechanical properties, component forming and post-forming properties will be evaluated. Also, the alloy production process, including thermomechanical processing (TMP) optimization to reduce production cost, will be investigated during SPITFIRE-2. After identifying preferred compositions and production processing, the most promising alloy will be manufactured into production coils for verification during SPITFIRE-3. Components will be produced from these coils in SPITFIRE-4, and the process and component performance will be assessed.

  2. 75 FR 27411 - Airworthiness Directives; Turbomeca Arriel 1B, 1D, 1D1, and 1S1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... (that incorporate Turbomeca Modification (mod) TU 148), Arriel 1D, 1D1, and 1S1 turboshaft engines that do not incorporate mod TU 347. That AD also requires initial and repetitive replacements of 2nd stage... incorporate mod TU 148), 1D, 1D1, and 1S1 turboshaft engines that do not incorporate mod TU 347. We...

  3. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations §§ 1.7872-11.7872-4...

  4. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  5. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations §§ 1.7872-11.7872-4...

  6. RAP1GA1: A candidate tumor suppressor locus in 1p36.1

    SciTech Connect

    Ranade, K.; Hussussian, C.J.; Higgins, P.

    1994-09-01

    The rap1/Krev-1 gene (RAP1A) encodes a p21-related protein that suppresses transformation by activated p21{sup ras}. The GTPase activating protein (GAP) gene for p21{sup rap1A} (RAP1GA1) has recently been assigned to chromosome 1p36.1-p35, a region of the genome that is frequently involved in deletions and rearrangements in several different tumors including breast, colon and hepatocellular carcinomas, melanoma, and neuroblastoma. GAP genes negatively regulate the activity of p21 proteins by catalyzing the conversion of the active GTP-bound forms to the inactive GDP-bound forms. The physiological function of p21{sup rap1A}-GAP makes it a strong candidate as a tumor suppressor gene that may have a role in the development of one or more of these malignancies. We have refined the localization of RAP1GA1 by linkage analysis with a highly informative (CA){sub n} repeat contained within the gene, and demonstrated that it is within the minimal deleted region for breast and colon carcinomas, and that it is excluded from the minimally deleted region in melanoma and neuroblastoma. Genetic mapping in the mouse demonstrated that Rap1ga1 is located {approximately}10 cM proximal to Pnd and therefore maps within the interval containing the modifier of Min gene (Mom-1) and the plasmocytoma susceptibility locus (Pcts). The human RAP1GA1 gene contains at least 27 exons. The coding region contains 22 exons, and there are at least five 5{prime}-UT exons that are assembled in a complex pattern of alternative splicing in different tissues. The localization of RAP1GA1 makes it a very strong candidate for a role as a modifier gene involved in the common secondary abnormalities involving 1p36 in several different carcinomas. The potential role of RAP1GA1 in these malignancies is currently being investigated by sequence analysis of breast and colon carcinomas with loss of heterozygosity in 1p36.

  7. The relationship between the 5-min oscillation and 3-min oscillations at the umbral/penumbral sunspot boundary

    NASA Astrophysics Data System (ADS)

    Zhou, Xinping; Liang, Hongfei

    2017-03-01

    Observations of the main sunspot of AR 11692 were carried out with the 1 m New Vacuum Solar Telescope (NVST) located on the Fuxian Solar Observatory (FSO) in Hα on March 13, 2013. The high cadence (up to 12 s) Hα intensity images help us to investigate the relationship between the 5-min oscillation and 3-min oscillation. It is found that running waves, periodically formed at the wave sources within umbra, propagate outward with the shape of partial arcs. The running waves run across the umbra-penumbra boundary and eventually disappear at the edge of penumbra. But there are obvious differences when we measure the period of running waves in different regions of a sunspot. The period is about 150 s when the running waves are located in umbra, which is a typical 3-min oscillation, and the period is about 300 s when the running waves are located in the penumbra, which is a typical 5-min oscillation. On the basis of time-slice images, we conclude that the waves form in the umbral region with the 5-min oscillation period, which can cause the brightness periodicity change in the umbra region with the 3-min period (in fact, is half of 5-min oscillation) and 5-min in the penumbra.

  8. Theoretical study of NH3 decomposition on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces: A comparison with clean Pd (1 1 1) and Cu (1 1 1)

    NASA Astrophysics Data System (ADS)

    Jiang, Zhao; Qin, Pei; Fang, Tao

    2016-05-01

    The adsorption and successive dehydrogenation mechanisms of NH3 on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces (the Pd atoms substitution of the first and second layers of Cu (1 1 1) surfaces) have been systematically investigated by density functional theory (DFT) method with a periodic slab model. All possible adsorption configurations of relevant intermediates on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces are identified. It is revealed that the adsorption configurations and corresponding adsorption energies of adsorbates are slightly changed on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces. The adsorption energies of NHx(x = 0-3) species exhibit the following trend: NH3 < NH2 < NH < N. Then, the minimum energy path for the complete dehydrogenation of NH3 into adsorbed N and H is identified to explore the dehydrogenation mechanisms on different surfaces. The highest energy barrier and reaction energy on Pd-Cu (1 1 1) surface are greatly reduced to 1.56 and 0.99 eV, implying that the complete dehydrogenation of NH3 on Pd-Cu (1 1 1) surface is favorable both kinetically and thermodynamically, namely, the doped-Pd atoms in the first layer are the reaction active center. Compared to that on clean Pd (1 1 1) and Cu (1 1 1) surfaces, it is found that the synergistic effect exits in different layers of catalyst surfaces. The calculated results show that the layer-substituted Pd atoms on the surface of Cu catalysts exhibit a better catalytic activity for NH3 dehydrogenation compared to the clean Cu (1 1 1) surface.

  9. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  10. Cordoba Durchmusterung, volume 1

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The 'Cordoba Durchmusterung' (CD) is a visual survey of southern stars in the declination zones -22 to -89 deg, carried out as an extension to the 'Bonner Durchmusterung' (BD) catalogs of Argelander and Schoenfeld. This volume covers the declination range -22 deg through -30 deg. The survey was performed using techniques similar to those used for the BD; i.e., the stars were cataloged by allowing the telescope to drift along the mean declination of each zone and recording the positions and magnitudes of stars crossing the transit line of the field. The goal of the survey was to obtain a position and estimated visual magnitude for every star down to 10.0 magnitude inclusive, but the faint limit was confirmed from comparisons with other catalogs, to be somewhat below 10. The positions are given to 0.1 s in right ascension and 0.1 min in declination for the equinox 1875. The positional uncertainties quoted in the original publications are plus or minus 0.42 s and plus or minus 0.23 min for zones -22 deg to -32 deg. A list of all corrections made to the original data as a result of published corrigenda is presented. No other corrections or changes were incorporated into the original data, e.g., from more modern positions and magnitudes or comparison with the 'Cape Photographic Durchmusterung'.

  11. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic policies... procedures for implementation of the Regulatory Flexibility Act which took effect January 1, 1981. (d) A...

  12. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  13. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  14. 8 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Definitions. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Definitions. As used in this... Service means the Immigration and Naturalization Service, as it existed prior to March 1, 2003....

  15. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  16. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic policies... procedures for implementation of the Regulatory Flexibility Act which took effect January 1, 1981. (d) A...

  17. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  18. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It is...

  19. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It is...

  20. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It...

  1. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It...

  2. Differential affinities of MinD and MinE to anionic phospholipid influence Min Patterning dynamics in vitro

    PubMed Central

    Vecchiarelli, Anthony G.; Li, Min; Mizuuchi, Michiyo; Mizuuchi, Kiyoshi

    2014-01-01

    The E. coli Min system forms a cell-pole-to-cell-pole oscillator that positions the divisome at mid-cell. The MinD ATPase binds the membrane and recruits the cell division inhibitor MinC. MinE interacts with and releases MinD (and MinC) from the membrane. The chase of MinD by MinE creates the in vivo oscillator that maintains a low level of the division inhibitor at mid-cell. In vitro reconstitution and visualization of Min proteins on a supported lipid bilayer has provided significant advances in understanding Min patterns in vivo. Here we studied the effects of flow, lipid composition, and salt concentration on Min patterning. Flow and no-flow conditions both supported Min protein patterns with somewhat different characteristics. Without flow, MinD and MinE formed spiraling waves. MinD and, to a greater extent MinE, have stronger affinities for anionic phospholipid. MinD-independent binding of MinE to anionic lipid resulted in slower and narrower waves. MinE binding to the bilayer was also more susceptible to changes in ionic strength than MinD. We find that modulating protein diffusion with flow, or membrane binding affinities with changes in lipid composition or salt concentration, can differentially affect the retention time of MinD and MinE, leading to spatiotemporal changes in Min patterning. PMID:24930948

  3. Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates

    PubMed Central

    Halberg, Richard B.; Larsen, Michele Campaigne; Elmergreen, Tammy L.; Ko, Alex Y.; Irving, Amy A.; Clipson, Linda; Jefcoate, Colin R.

    2008-01-01

    Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiological functions during embryogenesis, but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). We generated Cyp1b1-deficient mice carrying the Min allele of the Adenomatous polyposis coli gene. These Cyp1b1-deficient Min mice developed twice as many tumors as Min controls, which, however, remained similar in size and histology. Tumors from older (130 day) Cyp1b1-deficient Min mice exhibited focal areas of nuclear atypia associated with less organized epithelia. The metabolism of endogenous substrates by Cyp1b1, therefore, suppresses tumor initiation, but also affects progression. Treatment of Min mice with 7,12-dimethylbenzanthracene (DMBA) doubled both tumor multiplicity and size within 20 days, but not when mice lacked Cyp1b1. This was paralleled by an abnormal staining of crypts with β catenin, phospho-IKK, and ReIA, which may represent an early stage of tumorigenesis similar to aberrant crypt formation. Cyp1b1 deletion did not affect circulating DMBA and metabolites. Cyp1b1 expression was higher in the tumors compared to normal small intestines. Increased tumorigenesis may, therefore, arise from generation of DMBA metabolites by Cyp1b1 in the developing tumors. Benzo(a)pyrene (BP), which is similarly activated by Cyp1b1 in vitro, did not affect tumorigenesis in Min mice. By contrast, BP and DMBA each suppressed tumor multiplicity in absence of Cyp1b1. Cyp1b1 metabolism of DMBA and endogenous oxygenation products may each impact a tumor promoting NF-κB. activation, whereas Ah receptor activation by PAH effects suppression. Tumorigenesis may, therefore, depend on activation of PAH by Cyp1b1, and on off-setting suppression by Cyp1b1 of endogenous tumor-enhancing substrates. PMID:18794127

  4. 29 CFR 1.2 - Definitions. 1

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Definitions. 1 1.2 Section 1.2 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES § 1.2 Definitions. 1 1 These definitions... Assistance Act of 1972. (e) The term Wage Determinations OnLine (WDOL) shall mean the Government Internet...

  5. 29 CFR 1.2 - Definitions. 1

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Definitions. 1 1.2 Section 1.2 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES § 1.2 Definitions. 1 1 These definitions are... Assistance Act of 1972. (e) The term Wage Determinations OnLine (WDOL) shall mean the Government Internet...

  6. 29 CFR 1.2 - Definitions. 1

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Definitions. 1 1.2 Section 1.2 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES § 1.2 Definitions. 1 1 These definitions... Assistance Act of 1972. (e) The term Wage Determinations OnLine (WDOL) shall mean the Government Internet...

  7. 29 CFR 1.2 - Definitions. 1

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Definitions. 1 1.2 Section 1.2 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES § 1.2 Definitions. 1 1 These definitions... Assistance Act of 1972. (e) The term Wage Determinations OnLine (WDOL) shall mean the Government Internet...

  8. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  9. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  10. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  11. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  12. 49 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Purpose. This part describes the organization of the Department of Transportation and provides for...

  13. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  14. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  15. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  16. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  17. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  18. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  19. 17 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false 1.1 Section 1.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.1...

  20. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  1. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  2. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  3. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  4. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  5. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  6. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  7. 49 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Purpose. This part describes the organization of the Department of Transportation and provides for...

  8. 8 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Definitions. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Definitions. As used in this...) The term Service means the Immigration and Naturalization Service, as it existed prior to March...

  9. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  10. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  11. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  12. Metabolism of 1-fluoro-1,1,2-trichloroethane, 1,2-dichloro-1,1-difluoroethane, and 1,1,1-trifluoro-2-chloroethane.

    PubMed

    Yin, H; Jones, J P; Anders, M W

    1995-03-01

    1-Fluoro-1,1,2-trichloroethane (HCFC-131a), 1,2-dichloro-1,1-difluoroethane (HCFC-132b), and 1,1,1-trifluoro-2-chloroethane (HCFC-133a) were chosen as models for comparative metabolism studies on 1,1,1,2-tetrahaloethanes, which are under consideration as replacements for ozone-depleting chlorofluorocarbons (CFCs). Male Fischer 344 rats were given 10 mmol/kg ip HCFC-131a or HCFC-132b or exposed by inhalation to 1% HCFC-133a for 2 h. Urine collected in the first 24 h after exposure was analyzed by 19F NMR and GC/MS and with a fluoride-selective ion electrode for the formation of fluorine-containing metabolites. Metabolites of HCFC-131a included 2,2-dichloro-2-fluoroethyl glucuronide, 2,2-dichloro-2-fluoroethyl sulfate, dichlorofluoroacetic acid, and inorganic fluoride. Metabolites of HCFC-132b were characterized as 2-chloro-2,2-difluoroethyl glucuronide, 2-chloro-2,2-difluoroethyl sulfate, chlorodifluoroacetic acid, chlorodifluoroacetaldehyde hydrate, chlorodifluoroacetaldehyde-urea adduct, and inorganic fluoride. HCFC-133a was metabolized to 2,2,2-trifluoroethyl glucuronide, trifluoroacetic acid, trifluoroacetaldehyde hydrate, trifluoroacetaldehyde-urea adduct, inorganic fluoride, and a minor, unidentified metabolite. With HCFC-131a and HCFC-132b, glucuronide conjugates of 2,2,2-trihaloethanols were the major urinary metabolites, whereas with HCFC-133a, a trifluoroacetaldehyde-urea adduct was the major urinary metabolite. Analysis of metabolite distribution in vivo indicated that aldehydic metabolites increased as fluorine substitution increased in the order HCFC-131a < HCFC-132b < HCFC-133a. With NADPH-fortified rat liver microsomes, HCFC-133a and HCFC-132b were biotransformed to trifluoroacetaldehyde and chlorodifluoroacetaldehyde, respectively, whereas HCFC-131a was converted to dichlorofluoroacetic acid. No covalently bound metabolites were detected by 19F NMR spectroscopy.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... promulgated under that act. (c) The definition of package in § 1.20 and of principal display panel in §§...

  14. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  15. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  16. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  17. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  18. 45 CFR 1210.1-1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Purpose. 1210.1-1 Section 1210.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-1 Purpose. This...

  19. 45 CFR 1216.1-1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Purpose. 1216.1-1 Section 1216.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-1 Purpose. This...

  20. 45 CFR 1211.1-1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Purpose. 1211.1-1 Section 1211.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-1 Purpose. This part establishes procedures under which certain...

  1. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Policy. 51.1 Section 51.1 General Provisions OFFICE OF THE FEDERAL REGISTER INCORPORATION BY REFERENCE § 51.1 Policy. (a) Section 552(a) of title 5... and the Code of Federal Regulations. Those requirements which govern publication include— (1)...

  2. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  3. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  4. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  5. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  6. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  7. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  8. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Policy. 51.1 Section 51.1 General Provisions OFFICE OF THE FEDERAL REGISTER INCORPORATION BY REFERENCE § 51.1 Policy. (a) Section 552(a) of title 5... and the Code of Federal Regulations. Those requirements which govern publication include— (1)...

  9. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  10. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  11. 26 CFR 1.6001-1 - Records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Records. 1.6001-1 Section 1.6001-1 Internal... TAXES (CONTINUED) Records, Statements, and Special Returns § 1.6001-1 Records. (a) In general. Except as... to income, shall keep such permanent books of account or records, including inventories, as...

  12. 26 CFR 1.6001-1 - Records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Records. 1.6001-1 Section 1.6001-1 Internal... TAXES Information and Returns § 1.6001-1 Records. (a) In general. Except as provided in paragraph (b) of... permanent books of account or records, including inventories, as are sufficient to establish the amount...

  13. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Policy. 51.1 Section 51.1 General Provisions OFFICE OF THE FEDERAL REGISTER INCORPORATION BY REFERENCE § 51.1 Policy. (a) Section 552(a) of title 5... and the Code of Federal Regulations. Those requirements which govern publication include— (1)...

  14. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Policy. 51.1 Section 51.1 General Provisions OFFICE OF THE FEDERAL REGISTER INCORPORATION BY REFERENCE § 51.1 Policy. (a) Section 552(a) of title 5... and the Code of Federal Regulations. Those requirements which govern publication include— (1)...

  15. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Policy. 51.1 Section 51.1 General Provisions OFFICE OF THE FEDERAL REGISTER INCORPORATION BY REFERENCE § 51.1 Policy. (a) Section 552(a) of title 5... and the Code of Federal Regulations. Those requirements which govern publication include— (1)...

  16. 26 CFR 1.1481-1 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false 1.1481-1 Section 1.1481-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Mitigation of Effect of Renegotiation of Government Contracts § 1.1481-1 Tax on Transfers To Avoid Income Tax...

  17. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a),...

  18. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a),...

  19. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a), (b), or (c)...

  20. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a),...

  1. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a),...

  2. 26 CFR 1.936-1 - Elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Elections. 1.936-1 Section 1.936-1 Internal... TAXES Possessions of the United States § 1.936-1 Elections. (a) Making an election. A domestic corporation shall make an election under section 936(e), for any taxable year beginning after December...

  3. 26 CFR 1.72-1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Introduction. 1.72-1 Section 1.72-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.72-1 Introduction. (a)...

  4. 45 CFR 1220.1-1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Introduction. 1220.1-1 Section 1220.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PAYMENT OF VOLUNTEER LEGAL EXPENSES General § 1220.1-1 Introduction. Section 419 of the Domestic...

  5. 45 CFR 1211.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1211.1-1 Section 1211.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-1 Purpose. This part establishes procedures under which certain volunteers enrolled under Pub. L. 93-113...

  6. 45 CFR 1216.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1216.1-1 Section 1216.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-1 Purpose. This part establishes rules to assure that...

  7. 45 CFR 1210.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1210.1-1 Section 1210.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-1 Purpose. This part establishes procedures under which...

  8. IRIS Update Batch 1, Group 1

    EPA Science Inventory

    Update the following IRIS chemical dose-response assessments: Barium (cancer, RfC), o-Cresol (RfD, cancer), carbon disulfied (RfD, RfC), 1,1-Dichloroethane (cancer), 2,4-Dimethylphenol (RfD), 1,4-Dibromobenzene (RfD), 1-chloro-1,1-difluroelfane (RfC, Acetyl chloride (cancer),2,4...

  9. Min and Max Exponential Extreme Interval Values and Statistics

    ERIC Educational Resources Information Center

    Jance, Marsha; Thomopoulos, Nick

    2009-01-01

    The extreme interval values and statistics (expected value, median, mode, standard deviation, and coefficient of variation) for the smallest (min) and largest (max) values of exponentially distributed variables with parameter ? = 1 are examined for different observation (sample) sizes. An extreme interval value g[subscript a] is defined as a…

  10. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 321 and 387) shall be applicable also to...

  11. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 321 and 387) shall be applicable also to...

  12. The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis.

    SciTech Connect

    Park, Kyung-Tase; Wu, Wei; Battaile, Kevin P.; Lovell, Scott; Holyoak, Todd; Lutkenhaus, Joe

    2011-09-16

    In E. coli, MinD recruits MinE to the membrane, leading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear because the MinD-binding regions of MinE are sequestered within a six-stranded {beta} sheet and masked by N-terminal helices. minE mutations that restore interaction between some MinD and MinE mutants were isolated. These mutations alter the MinE structure leading to release of the MinD-binding regions and the N-terminal helices that bind the membrane. Crystallization of MinD-MinE complexes revealed a four-stranded {beta} sheet MinE dimer with the released {beta} strands (MinD-binding regions) converted to {alpha} helices bound to MinD dimers. These results identify the MinD-dependent conformational changes in MinE that convert it from a latent to an active form and lead to a model of how MinE persists at the MinD-membrane surface.

  13. The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis.

    PubMed

    Park, Kyung-Tae; Wu, Wei; Battaile, Kevin P; Lovell, Scott; Holyoak, Todd; Lutkenhaus, Joe

    2011-08-05

    In E. coli, MinD recruits MinE to the membrane, leading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear because the MinD-binding regions of MinE are sequestered within a six-stranded β sheet and masked by N-terminal helices. minE mutations that restore interaction between some MinD and MinE mutants were isolated. These mutations alter the MinE structure leading to release of the MinD-binding regions and the N-terminal helices that bind the membrane. Crystallization of MinD-MinE complexes revealed a four-stranded β sheet MinE dimer with the released β strands (MinD-binding regions) converted to α helices bound to MinD dimers. These results identify the MinD-dependent conformational changes in MinE that convert it from a latent to an active form and lead to a model of how MinE persists at the MinD-membrane surface.

  14. [Local fractal analysis of noise-like time series by all permutations method for 1-115 min periods].

    PubMed

    Panchelyuga, V A; Panchelyuga, M S

    2015-01-01

    Results of local fractal analysis of 329-per-day time series of 239Pu alpha-decay rate fluctuations by means of all permutations method (APM) are presented. The APM-analysis reveals in the time series some steady frequency set. The coincidence of the frequency set with the Earth natural oscillations was demonstrated. A short review of works by different authors who analyzed the time series of fluctuations in processes of different nature is given. We have shown that the periods observed in those works correspond to the periods revealed in our study. It points to a common mechanism of the phenomenon observed.

  15. Experimental capabilities of 0.4 PW, 1 shot/min Scarlet laser facility for high energy density science.

    PubMed

    Poole, P L; Willis, C; Daskalova, R L; George, K M; Feister, S; Jiang, S; Snyder, J; Marketon, J; Schumacher, D W; Akli, K U; Van Woerkom, L; Freeman, R R; Chowdhury, E A

    2016-06-10

    We report on the recently completed 400 TW upgrade to the Scarlet laser at The Ohio State University. Scarlet is a Ti:sapphire-based ultrashort pulse system that delivers >10  J in 30 fs pulses to a 2 μm full width at half-maximum focal spot, resulting in intensities exceeding 5×1021  W/cm2. The laser fires at a repetition rate of once per minute and is equipped with a suite of on-demand and on-shot diagnostics detailed here, allowing for rapid collection of experimental statistics. As part of the upgrade, the entire laser system has been redesigned to facilitate consistent, characterized high intensity data collection at high repetition rates. The design and functionality of the laser and target chambers are described along with initial data from commissioning experimental shots.

  16. ADAR1 restricts LINE-1 retrotransposition

    PubMed Central

    Orecchini, Elisa; Doria, Margherita; Antonioni, Ambra; Galardi, Silvia; Ciafrè, Silvia Anna; Frassinelli, Loredana; Mancone, Carmine; Montaldo, Claudia; Tripodi, Marco; Michienzi, Alessandro

    2017-01-01

    Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects. Concerning HIV-1, several studies showed that ADAR1 favors viral replication. The aim of this study was to investigate the composition of the ADAR1 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity purification procedure in cells expressing HIV-1 followed by mass spectrometry analysis, we identified 14 non-ribosomal ADAR1-interacting proteins, most of which are novel. A significant fraction of these proteins were previously demonstrated to be associated to the Long INterspersed Element 1 (LINE1 or L1) ribonucleoparticles and to regulate the life cycle of L1 retrotransposons that continuously re-enter host-genome. Hence, we investigated the function of ADAR1 in the regulation of L1 activity. By using different cell-culture based retrotransposition assays in HeLa cells, we demonstrated a novel function of ADAR1 as suppressor of L1 retrotransposition. Apparently, this inhibitory mechanism does not occur through ADAR1 editing activity. Furthermore, we showed that ADAR1 binds the basal L1 RNP complex. Overall, these data support the role of ADAR1 as regulator of L1 life cycle. PMID:27658966

  17. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  18. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  19. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  20. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  1. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  2. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the daily Federal Register in paper or microfiche form shall be made available to the following without charge:...

  3. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  4. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  5. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the daily Federal Register in paper or microfiche form shall be made available to the following without charge:...

  6. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  7. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  8. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. The Director of the Federal Register...

  9. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  10. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. The Director of the Federal Register...

  11. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  12. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  13. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  14. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER AVAILABILITY OF OFFICE OF THE FEDERAL REGISTER PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  15. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  16. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  17. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  18. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication... Federal Register shall publish a serial publication called the Federal Register to contain the...

  19. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  20. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  1. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication... Federal Register shall publish a serial publication called the Federal Register to contain the...

  2. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  3. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  4. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  5. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication... Federal Register shall publish a serial publication called the Federal Register to contain the...

  6. 48 CFR 1.602-1 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authority. 1.602-1 Section 1.602-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities...

  7. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  8. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  9. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  10. [Influenza pandemic (H1N1) 2009].

    PubMed

    Oshitani, Hitoshi

    2009-12-01

    In the past, influenza pandemics have been occurring every 20 to 30 years. Highly pathogenic avian influenza A(H5N1) has been causing unprecedented global outbreaks since 2003 and many human cases with a high case fatality rate have also been reported. But the virus that caused a pandemic in 2009 was A(H1N1) that was originated from swine influenza. The same subtype, A(H1N1) has been circulating in human population since 1977. This pandemic (H1N1) 2009 is also not as virulent as A(H5N1) in humans. Many aspects of pandemic (H1N1) 2009 are different from what we had been expecting. We should reconsider the concepts and the strategies for influenza pandemic by reviewing current pandemic (H1N1).

  11. Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

    PubMed

    Vachal, Petr; Toth, Leslie M; Hale, Jeffrey J; Yan, Lin; Mills, Sander G; Chrebet, Gary L; Koehane, Carol A; Hajdu, Richard; Milligan, James A; Rosenbach, Mark J; Mandala, Suzanne

    2006-07-15

    Novel series of sphingosine-1-phosphate (S1P) receptor agonists were developed through a systematic SAR aimed to achieve high selectivity for a single member of the S1P family of receptors, S1P1. The optimized structure represents a highly S1P1-selective and efficacious agonist: S1P1/S1P2, S1P1/S1P3, S1P1/S1P4>10,000-fold, S1P1/S1P5>600-fold, while EC50 (S1P1) <0.2 nM. In vivo experiments are consistent with S1P1 receptor agonism alone being sufficient for achieving desired lymphocyte-lowering effect.

  12. 48 CFR 1.603-1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.603-1 General... procurement career management program and a system for the selection, appointment, and termination...

  13. A Functional Genomic Analysis of NF1-Associated Learning Disabilities

    DTIC Science & Technology

    2008-08-01

    of 1 min at 948C, 1 min at 528C, and 1 min at 728C repeated 35 times, and 10 min at 728C. Contextual Discrimination Eight-week-old mice were used for...alpha 1.344 0.006 1450112_a_at Gas2 Growth arrest specific 2 1.206 0.049 1453193_s_at Kif12 Kinesin family member 12 21.863316 0.006 1456618_at Mark4 MAP...treatment up- regulated their expression (Fig. 5A). On the other hand, Sema6a, which critically regulates axonal growth in the hippocampus (Suto et al., 2007

  14. CheMin Instrument Performance and Calibration on Mars

    NASA Technical Reports Server (NTRS)

    Vaniman, D. T.; Blake, D. F.; Morookian, J. M.; Yen, A. S.; Ming, D. W.; Morris, R. V.; Achilles, C. N.; Bish, D. L.; Chipera, S. J.; Morrison, S. M.; Downs, R. T.; Rampe, E. B.; Sarrazin, P. C.; Treiman, A. H.; Anderson, R. C.; Bristow, T. F.; Crisp, J. A.; Des Marais, D. J.; Spanovich, N.; Wilson, M. A.

    2013-01-01

    The CheMin (Chemistry and Mineralogy) instrument on the Mars Science Laboratory rover Curiosity uses a CCD detector and a Co-anode X-ray tube source to acquire both mineralogy (from the pattern of Co diffraction) and chemical information (from energies of fluoresced X-rays). A key component of the CheMin instrument is the ability to move grains within sample cells during analysis, providing multiple, random grain orientations that disperse diffracted X-ray photons along Debye rings rather than producing discrete Laue spots. This movement is accomplished by piezoelectric vibration of the sample cells. A cryocooler is used to maintain the CCD at a temperature at about -50 C in order to obtain energy resolution better than 250 eV, allowing discrimination of diffracted Co K X-rays from Fe K and other fluorescent X-rays. A detailed description of CheMin is provided in [1]. The CheMin flight model (FM) is mounted within the body of Curiosity and has been operating on Mars since August 6, 2012. An essentially identical sister instrument, the CheMin demonstration model (DM), is operated in a Mars environment chamber at JPL.

  15. Inhibited 1,1,1-trichloroethane replaces trichloroethylene for degreasing

    NASA Technical Reports Server (NTRS)

    Schuler, F. T.

    1970-01-01

    In fight against air pollution inhibited TCE /1,1,1-trichloroethane/ is effective substitute for trichloroethylene in degreasing plants. This chemical has only slight photochemical activity and causes little eye irritation. TCE is less toxic than trichloroethylene and can withstand production loads and conditions, or long term storage, without degradation.

  16. Get Ready for 1:1

    ERIC Educational Resources Information Center

    Moore, Darcy

    2009-01-01

    Good planning can make or break a successful 1:1 program. The author, a long-time deputy principal with extensive EdTech experience, shares his insights on how to get the most out of 1:1. Read these tips before getting started or improving an existing program.

  17. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2011-08-16

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  18. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2011-05-31

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  19. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits [Vlaardingen, NL; Gualfetti, Peter [San Francisco, CA; Mitchinson, Colin [Half Moon Bay, CA; Larenas, Edmund [Moss Beach, CA

    2012-08-07

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  20. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2008-12-02

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  1. Variant humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Edmund, Larenas

    2014-09-09

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  2. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegeburr, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2013-02-19

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  3. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2014-03-18

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  4. 2016 SPD: Day 1

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-06-01

    Editors note: This week were in Boulder, Colorado at the 47th meeting of the AAS Solar Physics Division (SPD). Follow along to catch some of the latest news from the field of solar physics!The 2016 SPD meeting was launched this morning from the University of Colorado Boulder campus. Two of the hot topics at this years meeting include celebration of the recent move of the National Solar Observatorys headquarters to Boulder, and discussion of the future Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST). DKIST, planned for a 2019 completion in Hawaii, is the next big telescope on the horizon for solar physics.Todays press conference had an interesting focus: instruments providing new high-energy observations of the Sun. Representatives from four different instruments were here to talk about some of the latest X-ray solar observations.GRIPSThe GRIPS payload flew at 130,000 ft over Antarctica on a giant balloon in January 2016. [NASA/Albert Shih]First up, Albert Shih (NASA Goddard) described the Gamma-Ray Imager/Polarimeter for Solar flares, or GRIPS. GRIPS is a balloon-borne instrument designed to detect X-rays and gamma rays emitted during solar flares. Up to tens of a percent of the energy in solar flares is emitted in the form of accelerated particles, but the physics behind this process is not well understood. GRIPS observes where the highest-energy particles are accelerated, in an effort to learn more about the process.GRIPS was launched on 19 January, 2016 and flew for roughly 12 days gathering ~1 million seconds of data! The logistics of this instruments flight are especially interesting, since it was launched from Antarctica and carried by a balloon at a whopping elevation of 130,000 ft (to get high enough that the atmosphere doesnt absorb all the photons GRIPS is trying to observe). Though the data from the mission has been retrieved, the bulk of the hardware remains where it landed at the end of January. It must

  5. Adsorption and hydrogenation of CO on Pd( 1 1 1 ) and Rh( 1 1 1 ) modified by subsurface vanadium

    NASA Astrophysics Data System (ADS)

    Klötzer, Bernhard; Unterberger, Werner; Hayek, Konrad

    2003-06-01

    On Pd(1 1 1) and Rh(1 1 1) a subsurface alloy of V atoms located mainly in the second metal layer is formed by vapor deposition of V at elevated temperatures. The topmost layer consists exclusively of Pd or Rh atoms in √3×√3 R30° geometry. Neither reversible adsorption of CO under UHV conditions nor hydrogenation of CO at atmospheric pressure lead to surface segregation of V compounds. Numerical simulation and threshold temperature programmed desorption analysis of CO TPD series obtained from the clean and V modified samples showed that the presence of subsurface V significantly reduces the desorption energy of molecular CO over a wide coverage range and changes the coverage-dependence of the desorption energy. The presence of subsurface V atoms promotes CO hydrogenation on both Pd(1 1 1) and Rh(1 1 1). The enhanced catalytic activity is interpreted in view of the reduced CO desorption energies and of surface roughening induced by subsurface alloy growth.

  6. Gompertz type dechanneling functions for protons in <1 0 0>, <1 1 0> and <1 1 1> Si crystal channels

    NASA Astrophysics Data System (ADS)

    Petrović, S.; Erić, M.; Kokkoris, M.; Nešković, N.

    2007-03-01

    In this work the energy dependences of the Gompertz type sigmoidal dechanneling function parameters for protons in <1 0 0>, <1 1 0> and <1 1 1> Si crystal channels is investigated theoretically. The proton energy range considered is between 1 and 10 MeV. The original dechanneling functions are generated using a realistic Monte Carlo computer simulation code. We show that the Gompertz type dechanneling function, having two parameters, lc and k, representing the dechanneling range and rate, respectively, approximate accurately the original dechanneling function. It is also shown that the energy dependences of parameters lc and k can be approximated by a linear function and a sum of two exponential functions, respectively. The results obtained can be used for accurate reproduction of experimental proton channeling spectra recorded in the backscattering geometry.

  7. A1C test

    MedlinePlus

    HbA1C test; Glycated hemoglobin test; Glycohemoglobin test; Hemoglobin A1C; Diabetes - A1C; Diabetic - A1C ... gov/pubmed/26696680 . Chernecky CC, Berger BJ. Glycosylated hemoglobin (GHb, glycohemoglobin, glycated hemoglobin, HbA1a, HbA1b, HbA1c - blood. ...

  8. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2) Executive... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each...

  9. The Neurofibromatoses. Part 1: NF1.

    PubMed

    Lu-Emerson, Christine; Plotkin, Scott R

    2009-01-01

    The neurofibromatoses, including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis, comprise a group of genetically distinct disorders of the nervous system unified by the predisposition to nerve sheath tumors. NF1 is the most common neurogenetic disorder, with a birth incidence of 1 in 3000. NF1 is inherited in auto-somal dominant fashion with full penetrance and variable expressivity. The hallmark lesion of NF1 is the neurofibroma, a benign tumor derived from the nerve sheath and composed of a mixture of proliferating Schwann cells, fibroblasts, mast cells, and pericytes. Other findings include gliomas, learning disability, vasculopathy, and bony abnormalities. Café au lait macules are typically the initial clinical manifestation of NF1 and tend to increase in size and number throughout childhood and puberty. Current treatment of patients with NF1 remains primarily surgical. Genetic counseling is essential for adult patients because molecular diagnostic testing can minimize the risk of transmission to children.

  10. 26 CFR 1.508-1 - Notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) Private Foundations § 1.508-1 Notices. (a) New organizations must notify the Commissioner that...) Voluntary filings by new organizations excepted from filing notice. Any organization excepted from the...) Presumption that old and new organizations are private foundations—(1) In general. Except as provided...

  11. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It is the... have other severe disabilities through the purchase of commodities and services from qualified nonprofit agencies employing persons who are blind or have other severe disabilities. The Committee...

  12. 1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity.

    PubMed

    Hu, Tianhui; Exton, John H

    2005-02-25

    1-Butanol is commonly used as a substrate for phospholipase D (PLD) activity measurement. Surprisingly we found that, in the presence of 30 mM 1-butanol (standard PLD assay conditions), PLD1 activity in COS-7 cells was lost after incubation for 2 min. In contrast, in the presence of the protein kinase C (PKC) inhibitor staurosporine or dominant negative PKCalpha D481E, the activity was sustained for at least 30min. The binding between PLD1 and PKCalpha was also lost after 2 min incubation with 30 mM 1-butanol while staurosporine and D481E maintained the binding. 1-Butanol at 2 mM did not inhibit PLD1 basal activity or PLD1 binding to PKCalpha, and staurosporine and PKCalpha D481E produced a constant increase in PLD1 basal activity of 2-fold. These results indicate that 1-butanol is inhibitory to PLD1 activity by reducing its association with PKCalpha, and that the concentration of 1-butanol is an important consideration in assaying basal PLD1 activity.

  13. CHARICE version 1.1 update.

    SciTech Connect

    Davis, Jean-Paul

    2008-10-01

    CHARICE (CHARacteristics-based inverse analysis of Isentropic Compression Experiments) is a computer application, previously documented in SAND2007-4948, that analyzes velocity waveform data from ramp-wave experiments to determine a material's quasi-isentropic loading response in stress and density using an iterative characteristics-based approach. This short report documents only the changes in CHARICE release version 1.1 relative to release version 1.0, and is not intended to stand alone. CHARICE version 1.1 corrects an error in the algorithm of the method, fixes several bugs, improves robustness and performance, provides more useful error descriptions, and adds a number of minor features.

  14. Min and Max Extreme Interval Values

    ERIC Educational Resources Information Center

    Jance, Marsha L.; Thomopoulos, Nick T.

    2011-01-01

    The paper shows how to find the min and max extreme interval values for the exponential and triangular distributions from the min and max uniform extreme interval values. Tables are provided to show the min and max extreme interval values for the uniform, exponential, and triangular distributions for different probabilities and observation sizes.

  15. High resolution infrared spectroscopy of [1.1.1]propellane

    NASA Astrophysics Data System (ADS)

    Kirkpatrick, Robynne; Masiello, Tony; Jariyasopit, Narumol; Weber, Alfons; Nibler, Joseph W.; Maki, Arthur; Blake, Thomas A.; Hubler, Timothy

    2008-04-01

    The infrared spectrum of [1.1.1]propellane has been recorded at high resolution (0.002 cm -1) with individual rovibrational lines resolved for the first time. This initial report presents the ground state constants for this molecule determined from the analysis of five of the eight infrared-allowed fundamentals ν9(e'), ν10(e'), ν12(e'), ν14(a2″),ν15(a2″), as well as of several combination bands. In nearly all cases it was found that the upper states of the transitions exhibit some degree of perturbation but, by use of the combination difference method, the assigned frequencies provided over 4000 consistent ground state difference values. Analysis of these gave for the parameters of the ground state the following values, in cm -1: B0 = 0.28755833(14), DJ = 1.1313(5) × 10 -7, DJK = -1.2633(7) × 10 -7, HJ = 0.72(4) × 10 -13, HJK = -2.24(13) × 10 -13, and HKJ = 2.25(15) × 10 -13, where the numbers in parentheses indicate twice the uncertainties in the last quoted digit(s) of the parameters. Gaussian ab initio calculations, especially with the computed anharmonic corrections to some of the spectroscopic parameters, assisted in the assignments of the bands and also provided information on the electron distribution in the bridge-head carbon-carbon bond.

  16. Spatial heterogeneity of surface roughness during different erosive stages of tilled loess slopes under a rainfall intensity of 1.5 mm min-1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The loess tilled slope is the main place for soil erosion in Chinese Loess Plateau, and studies about its spatial heterogeneity (SH) of surface roughness (SR) has been one of the most important problems in the field of soil erosion. The objective of this study was to reveal the SH of SR of 4 typical...

  17. Growth of monocrystalline Cu(1 1 1) films on MgO(1 1 1) by pulsed laser deposition

    NASA Astrophysics Data System (ADS)

    Aweke, F.; Antoni, F.; Hulik, J.; Morvan, G.; Speisser, C.; Veis, P.; Le Normand, F.

    2015-05-01

    Copper (Cu) films with a minimal thickness of 300 nm were grown on MgO(1 1 1) substrates in high vacuum by pulsed laser deposition (PLD) at various temperatures to achieve a single crystal Cu film with flat terraces without grain boundaries. We investigated the effect of the substrate temperature, the pulse repetition rate, the deposition time and the laser fluence. A temperature threshold is observed above which the growth mode is changed from a uniform flat mode to a three dimensional mode. A combined process involving a germination step at moderate temperature followed by a growth step at higher temperature yields a 450 nm almost continuous film.

  18. Ciencias 1. (Science 1). [Student's Workbook].

    ERIC Educational Resources Information Center

    Raposo, Lucilia

    Ciencias 1 is the first in a series of science books designed for elementary Portuguese-speaking students. The book contains five sections divided into 43 lessons. The five sections are (1) Matter, (2) The Human Body, (3) Weather, (4) Solids, Liquids, and Gases, and (5) Living Things. Pictorial presentations and picture exercises are included for…

  19. General Relativity in (1 + 1) Dimensions

    ERIC Educational Resources Information Center

    Boozer, A. D.

    2008-01-01

    We describe a theory of gravity in (1 + 1) dimensions that can be thought of as a toy model of general relativity. The theory should be a useful pedagogical tool, because it is mathematically much simpler than general relativity but shares much of the same conceptual structure; in particular, it gives a simple illustration of how gravity arises…

  20. 26 CFR 302.1-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-1 Definitions. (a...” includes the officer in whom property is vested pursuant to title II of the International Claims Settlement..., increment, or proceeds thereof. (g) Act. The term “Act” means the International Claims Settlement Act...

  1. 48 CFR 1.603-1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.603-1 General... procurement career management program and a system for the selection, appointment, and termination of... Office of Federal Procurement Policy's (OFPP) standards for skill-based training in...

  2. Expect Surprises with 1-to-1 Laptops

    ERIC Educational Resources Information Center

    Tusch, Erich G.

    2012-01-01

    In 2004, prior to the launch of their 1-to-1 laptop program, the superintendent expressed some anxiety about the prospect of radically changing teaching and learning by issuing a laptop computer to every student and teacher. Although the concept was exciting, it carried big risks and would take time and thorough planning to execute well. Even with…

  3. 1,1,2,2-Tetrachloroethane

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 09 / 001 F www.epa.gov / iris TOXICOLOGICAL REVIEW OF 1,1,2,2 - TETRACHLOROETHANE ( CAS No . 79 - 34 - 5 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) September 2010 U.S . Environmental Protection Agency Washington , DC ii DISCLAIMER This docu

  4. 7 CFR 1b.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Secretary of Agriculture NATIONAL ENVIRONMENTAL POLICY ACT § 1b.1 Purpose. (a) This part supplements the regulations for implementation of the National Environmental Policy Act (NEPA), for which regulations were published by the Council on Environmental Quality (CEQ) in 40 CFR parts 1500 through 1508. This...

  5. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAXES Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life insurance company as used in subtitle A of the Code is defined in section 801. For the purpose of determining whether a company is a “life insurance company” within the meaning of that term as used in...

  6. [1+1+1] Cyclotrimerization for the Synthesis of Cyclopropanes

    PubMed Central

    Manna, Srimanta

    2016-01-01

    Abstract The synthesis of small rings by functionalization of C(sp3)−H bonds remains a great challenge. We report for the first time a copper‐catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives under mild reaction conditions. The reaction has a broad scope for the stereoselective synthesis of cyclopropanes by trimerization of acetophenone. The developed transformation is based on an extraordinary copper‐catalyzed cascade process that allows saturated carbocycles to be obtained for the first time by cyclotrimerization through functionalization of C(sp3)−H bonds. The cascade of sixfold C(sp3)−H bond functionalization allows the synthesis of cyclopropanes in a highly stereoselective approach. PMID:26997466

  7. A Linear Max-Min Problem,

    DTIC Science & Technology

    The report discusses a two person max -min problem in which the maximizing player moves first and the minimizing player has perfect information of the...The joint constraints as well as the objective function are assumed to be linear. For this problem it is shown that the familiar inequality min max ...or = max min is reversed due to the influence of the joint constraints. The problem is characterized as a nonconvex program and a method of

  8. Grumman JF-1 Duck

    NASA Technical Reports Server (NTRS)

    1934-01-01

    Grumman JF-1 Duck: The Grumman JF-1 Duck was in service with the NACA at Langley during the summer of 1934. The JF-1 was notably different from the later J2F Duck in that the JF-1 had a shorter central float. The NACA used the JF-1 in part as a propeller testbed aircraft.

  9. Glide of dislocations in <1 1 1>{3 2 1} slip system: an atomistic study

    NASA Astrophysics Data System (ADS)

    Terentyev, D.; Bakaev, A.; Van Neck, D.; Zhurkin, E. E.

    2016-01-01

    Atomistic calculations are performed to investigate plastic slip in the <1 1 1>{3 2 1} system in body-centred cubic iron. Several modern interatomic potentials, developed over the last decade, are applied to compute the stacking fault γ-line energy in the {3 2 1} plane and the results are compared with the ab initio prediction. The applied potentials have shown strong deviations, but several potentials acquired good qualitative agreement with the ab initio data. Depending on the applied potential, the lowest value of the Peierls stress for the edge dislocation (ED) is 50 MPa (Ackland and Bacon from 1997) and the highest is 550 MPa (Dudarev and Derlet from 2005), while for the screw dislocation it is much higher, in the range 1-2 GPa. At finite temperature, however, the flow stress of the ED is found to decrease exponentially reaching a negligible value at about 200 K, irrespective of the applied potential. On the basis of the data obtained using Ackland-Mendelev potential from 2004, we conclude that the slip resistance of the <1 1 1>{3 2 1} system is in between the resistance of the <1 1 1>{1 1 0} and <1 1 1>{1 1 2} slip systems.

  10. IL-1 Blockade in Autoinflammatory Syndromes1

    PubMed Central

    Jesus, Adriana A.; Goldbach-Mansky, Raphaela

    2014-01-01

    Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)–regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular “molecular sensor” that forms a multimolecular platform, the NLRP3 inflammasome, which links “danger recognition” to the activation of the proinflammatory cytokine IL-1β. The success and safety profile of drugs targeting IL-1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor–associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still’s, Behcet’s, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1β-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

  11. 26 CFR 1.508-1 - Notices.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and clarifying regulations designated as § 1.170A-9(e)(10) become final; (ii) In the case of medical research organizations, 6 months after the date on which corrective and clarifying regulations...

  12. 26 CFR 1.508-1 - Notices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and clarifying regulations designated as § 1.170A-9(e)(10) become final; (ii) In the case of medical research organizations, 6 months after the date on which corrective and clarifying regulations...

  13. SPARK Version 1. 1 user manual

    SciTech Connect

    Weissenburger, D.W.

    1988-01-01

    This manual describes the input required to use Version 1.1 of the SPARK computer code. SPARK 1.1 is a library of FORTRAN main programs and subprograms designed to calculate eddy currents on conducting surfaces where current flow is assumed zero in the direction normal to the surface. Surfaces are modeled with triangular and/or quadrilateral elements. Lorentz forces produced by the interaction of eddy currents with background magnetic fields can be output at element nodes in a form compatible with most structural analysis codes. In addition, magnetic fields due to eddy currents can be determined at points off the surface. Version 1.1 features eddy current streamline plotting with optional hidden-surface-removal graphics and topological enhancements that allow essentially any orientable surface to be modeled. SPARK also has extensive symmetry specification options. In order to make the manual as self-contained as possible, six appendices are included that present summaries of the symmetry options, topological options, coil options and code algorithms, with input and output examples. An edition of SPARK 1.1 is available on the Cray computers at the National Magnetic Fusion Energy Computer Center at Livermore, California. Another more generic edition is operational on the VAX computers at the Princeton Plasma Physics Laboratory and is available on magnetic tape by request. The generic edition requires either the GKS or PLOT10 graphics package and the IMSL or NAG mathematical package. Requests from outside the United States will be subject to applicable federal regulations regarding dissemination of computer programs. 22 refs.

  14. EMODEL_1D v. 1.0

    SciTech Connect

    Aldridge, David F.

    2016-07-06

    Program EMODEL_1D is an electromagnetic earth model construction utility designed to generate a three-dimensional (3D) uniformly-gridded representation of one-dimensional (1D) layered earth model. Each layer is characterized by the isotropic EM properties electric permittivity ?, magnetic permeability ?, and current conductivity ?. Moreover, individual layers of the model may possess a linear increase/decrease of any or all of these properties with depth.

  15. Glucose transporter type1 (GLUT-1) deficiency.

    PubMed

    Gordon, Neil; Newton, Richard W

    2003-10-01

    Glucose transporter type1 (GLUT-1) deficiency may be rare, but it is a preventable cause of severe learning difficulties; and therefore there is an urgency in making an early diagnosis. Suspicions must be roused when intractable seizures occur in infancy. These may be associated with acquired microcephaly and developmental delay. The finding of low glucose sugar levels in the cerebrospinal fluid, but not in the blood will identify the condition. The gene encoding the GLUT-1 protein is located on the short arm of chromosome 1, and inheritance is by a dominant trait. Patients with this syndrome can have heterozygous mutations, with one allele being a normal wild type and one being mutant. An efficient transport of glucose across the blood-brain barrier is essential as it is such an important fuel for the brain, and this is provided by glucose transporter type1 in the endothelial cells of the brain capillaries. Another minor contribution to the symptomatology of GLUT-1 may be impaired transport of an oxidised form of vitamin C. Treatment with anti-epileptic drugs may be needed, and the ketogenic diet may reduce symptoms, as ketosis can provide an alternative source of fuel for the brain. It has also been suggested that antioxidant thioctic acid may be of benefit. Substances such as caffeine and phenobarbitone should be avoided as they inhibit glucose transport.

  16. The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

    PubMed Central

    Miyagi, Shogo J.

    2011-01-01

    UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of drugs, chemicals, and hormones. The development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples using bilirubin, serotonin activity assays, and Western blot as well as pharmacokinetic scaling. UGT activity developed age dependently in pediatric liver. Maximal activity of 0.7690 nmol · min · −1 mg protein−1 was observed for UGT1A1 at 3.8 months. For UGT1A6, activity matured at 14 months (4.737 nmol · min · −1mg protein−1). Protein expression was not age-dependent, and activities did not correlate to protein levels for either enzyme. The in vitro activities were used to calculate normalized hepatic clearances using both allometric scaling and a physiologically based pharmacokinetic model. For UGT1A1, allometry predicted normalized adult clearances of 0.0070 l · h−1 · kg−1 at 3.0 (well stirred) and 2.8 years (parallel tube), whereas the Simcyp model showed normalized clearances of 0.0079 l · h−1 · kg−1 at 2.6 (well stirred) and 2.5 years (parallel tube). For UGT1A6, only the Simcyp well stirred model converged at 0.3524 l · h−1 · kg−1 at 12.6 months. These data imply independent regulation of UGT1A1 and 1A6 where activity has matured after 6 months to 1 year. Total hepatic clearance of substances mediated by these enzymes may mature concurrently or take longer because of other physiological factors. Late development of UGT enzymes may contribute to chemical, drug, and environmental toxicity. PMID:21266593

  17. [Glucose transporter type 1 (GLUT-1) deficiency].

    PubMed

    Cano, A; Ticus, I; Chabrol, B

    2008-11-01

    Impaired glucose transport across the blood brain barrier results in glucose transporter type 1 (GLUT-1) deficiency syndrome, first described in 1991. It is characterized by infantile seizures refractory to anticonvulsive treatments, microcephaly, delays in mental and motor development, spasticity, ataxia, dysarthria and other paroxysmal neurologic phenomena, often occurring prior to meals. Affected infants are normal at birth following an uneventful pregnancy and delivery. Seizures usually begin between the age of one and four months and can be preceded by apneic episodes or abnormal eyes movements. Patients with atypical presentations such as mental retardation and intermittent ataxia without seizures, or movement disorders characterized by choreoathetosis and dystonia, have also been described. Glucose is the principal fuel source for the brain and GLUT-1 is the only vehicle by which glucose enters the brain. In case of GLUT-1 deficiency, the risk of clinical manifestations is increased in infancy and childhood, when the brain glucose demand is maximal. The hallmark of the disease is a low glucose concentration in the cerebrospinal fluid in a presence of normoglycemia (cerebrospinal fluid/blood glucose ratio less than 0.4). The GLUT-1 defect can be confirmed by molecular analysis of the SCL2A1 gene or in erythrocytes by glucose uptake studies and GLUT-1 immunoreactivity. Several heterozygous mutations, with a majority of de novo mutations, resulting in GLUT-1 haploinsufficiency, have been described. Cases with an autosomal dominant transmission have been established and adults can exhibit symptoms of this deficiency. Ketogenic diet is an effective treatment of epileptic manifestations as ketone bodies serve as an alternative fuel for the developing brain. However, this diet is not effective on cognitive impairment and other treatments are being evaluated. The physiopathology of this disorder is partially unclear and its understanding could explain the clinical

  18. Adsorption and reaction of methanethiol on Pt(1 1 1)

    NASA Astrophysics Data System (ADS)

    Lin, T. H.; Huang, T. P.; Liu, Y. L.; Yeh, C. C.; Lai, Y. H.; Hung, W. H.

    2005-03-01

    Adsorption and thermal decomposition of H 3CSH on Pt(1 1 1) is studied with temperature-programmed desorption (TPD) and X-ray photoelectron spectroscopy (XPS) with synchrotron radiation. A H 3CSH molecule undergoes dehydrogenation via formation of H xCS ( x ⩽ 3) intermediates. The catalytic reactivity of Pt for dehydrogenation, which depends on interaction between the surface and the CH x moiety of H xCS, varies with coverage. At large coverage, H 3CSH decomposes through desorbing hydrogen via stepwise dehydrogenation (H 3CS → H 2CS → HCS → S + C). H 2CS is proposed to be an intermediate for dehydrogenation of H 3CS below 240 K, and subsequently undergoes disproportionation to form HCS with desorption of CH 4 at 400 K. The HCS species further decomposes to desorb hydrogen at 475 K and to form C and S adatoms; these adatoms show a mixed (√{3}×√{3})R30° and dim c(2 × 2) LEED pattern at saturation exposure. At small coverage, surface Pt exhibits a catalytic effect on dehydrogenation of H xCS via interaction of the CH x moiety with surface Pt atoms. Dehydrogenation of H 3CSH is completed below 370 K and is proposed to form a surface C sbnd S species; this species entirely decomposes to form C and S adatoms at 570 K.

  19. Cold Sores (HSV-1)

    MedlinePlus

    ... A Week of Healthy Breakfasts Shyness Cold Sores (HSV-1) KidsHealth > For Teens > Cold Sores (HSV-1) A A A What's in this article? ... or around a person's lips, are caused by herpes simplex virus-1 (HSV-1) . But they don't ...

  20. MISR Level 1A CCD, 1B1, 1B2, and Browse Products

    Atmospheric Science Data Center

    2013-04-01

    ... 1B1 Radiance, CCD Science;  Local Mode Data (Hi-Res Target Scenes): Terrain/Ellipsoid-Projected Radiance, 1B1 Radiance ... transform fix. ROI Image Matching improvements to blunder detection algorithm and to Image Coordinate Correction. New ancillary ...

  1. Master equipment list -- Phase 1. Revision 1

    SciTech Connect

    Jech, J.B.

    1995-04-28

    The purpose of this document is to define the system requirements for the Master Equipment List (MEL) Phase 1 project. The intended audience for this document includes Data Automation Engineering (DAE), Configuration Management Improvement and Control Engineering (CMI and CE), Data Administration Council (DAC), and Tank Waste Remedial System (TWRS) personnel. The intent of Phase 1 is to develop a user-friendly system to support the immediate needs of the TWRS labeling program. Phase 1 will provide CMI and CE the ability to administrate, distribute, and maintain key information generated by the labeling program. CMI and CE is assigning new Equipment Identification Numbers (EINs) to selected equipment in Tank Farms per the TWRS Data Standard ``Tank Farm Equipment Identification Number``. The MEL Phase 1 system will be a multi-user system available through the HLAN network. It will provide basic functions such as view, query, and report, edit, data entry, password access control, administration and change control. The scope of Phase 1 data will encompass all Tank Farm Equipment identified by the labeling program. The data will consist of fields from the labeling program`s working database, relational key references and pointers, safety class information, and field verification data.

  2. Discoidin Domain Receptor 1

    PubMed Central

    Song, Sunmi; Shackel, Nicholas A.; Wang, Xin M.; Ajami, Katerina; McCaughan, Geoffrey W.; Gorrell, Mark D.

    2011-01-01

    Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and is activated by collagens. Transcriptional profiling of cirrhosis in human liver using a DNA array and quantitative PCR detected elevated mRNA expression of DDR1 compared with that in nondiseased liver. The present study characterized DDR1 expression in cirrhotic and nondiseased human liver and examined the cellular effects of DDR1 expression. mRNA expression of all five isoforms of DDR1 was detected in human liver, whereas DDR1a demonstrated differential expression in liver with hepatitis C virus and primary biliary cirrhosis compared with nondiseased liver. In addition, immunoblot analysis detected shed fragments of DDR1 more readily in cirrhotic liver than in nondiseased liver. Inasmuch as DDR1 is subject to protease-mediated cleavage after prolonged interaction with collagen, this differential expression may indicate more intense activation of DDR1 protein in cirrhotic compared with nondiseased liver. In situ hybridization and immunofluorescence localized intense DDR1 mRNA and protein expression to epithelial cells including hepatocytes at the portal-parenchymal interface and the luminal aspect of the biliary epithelium. Overexpression of DDR1a altered hepatocyte behavior including increased adhesion and less migration on extracelular matrix substrates. DDR1a regulated extracellular expression of matrix metalloproteinases 1 and 2. These data elucidate DDR1 function pertinent to cirrhosis and indicate the importance of epithelial cell–collagen interactions in chronic liver injury. PMID:21356365

  3. Human Immunodeficiency Virus-1 (HIV-1)

    DTIC Science & Technology

    1991-03-19

    Immunodeficiency Virus (HIV)," September 11, 1987 (hereby canceled) 1d) Assistant Secretary of Defense (Health Affairs) Memorandum, ’) "The DoD HTLV -III...Testing Blood and Plasma for Antibodies to HTLV -III," July 17, 1985 (hereby canceled) (f) DoD Instruction 1438.4, "Compliance with Host Nation Human...partial or complete cutaneous anergy. In staging, if the CD4 number is 400 cells per mm3 , or greater, the individual shall be placed in stage 1 or 2

  4. Cardiomyopathy from 1,1-Difluoroethane Inhalation.

    PubMed

    Kumar, Suwen; Joginpally, Tejaswini; Kim, David; Yadava, Mrinal; Norgais, Konchok; Laird-Fick, Heather S

    2016-10-01

    Consumer aerosol products can be inhaled for their psychoactive effects, but with attendant adverse health effects including "sudden sniffing death." Cardiomyopathy has rarely been described in association with 1,1-difluoroethane (DFE), a common aerosol propellant. We report a 33-year-old male who developed acute myocardial injury and global hypokinesis along with rhabdomyolysis, acute kidney injury, and fulminant hepatitis after 2 days' nearly continuous huffing. Workup for other causes, including underlying coronary artery disease, was negative. His cardiac function improved over time. The exact mechanism of DFE's effects is uncertain but may include catecholamine-induced cardiomyopathy, coronary vasospasm, or direct cellular toxicity.

  5. Entanglement tsunami in (1 +1 )-dimensions

    NASA Astrophysics Data System (ADS)

    Leichenauer, Stefan; Moosa, Mudassir

    2015-12-01

    We study the time dependence of the entanglement entropy of disjoint intervals following a global quantum quench in (1 +1 )-dimensional CFTs at large c with a sparse spectrum. The result agrees with a holographic calculation but differs from the free field theory answer. In particular, a simple model of free quasiparticle propagation is not adequate for CFTs with a holographic dual. We elaborate on the entanglement tsunami proposal of Liu and Suh and show how it can be used to reproduce the holographic answer.

  6. The Asymptotics of Quantum Max-Flow Min-Cut

    NASA Astrophysics Data System (ADS)

    Hastings, Matthew B.

    2016-11-01

    The quantum max-flow min-cut conjecture relates the rank of a tensor network to the minimum cut in the case that all tensors in the network are identical in Calegari et al. (J Am Math Soc 23(1):107-188, 2010). This conjecture was shown to be false in Cui et al. (J Math Phys 57:062206, 2016) by an explicit counter-example. Here, we show that the conjecture is almost true, in that the ratio of the quantum max-flow to the quantum min-cut converges to 1 as the dimension N of the degrees of freedom on the edges of the network tends to infinity. The proof is based on estimating moments of the singular values of the network. We introduce a generalization of "rainbow diagrams" to tensor networks to estimate the dominant diagrams. A direct comparison of second and fourth moments lower bounds the ratio of the quantum max-flow to the quantum min-cut by a constant. To show the tighter bound that the ratio tends to 1, we consider higher moments. In addition, we show that the limiting moments as N → ∞ agree with that in a different ensemble where tensors in the network are chosen independently; this is used to show that the distributions of singular values in the two different ensembles weakly converge to the same limiting distribution. We present also a numerical study of one particular tensor network, which shows a surprising dependence of the rank deficit on N mod 4 and suggests further conjecture on the limiting behavior of the rank.

  7. The Asymptotics of Quantum Max-Flow Min-Cut

    NASA Astrophysics Data System (ADS)

    Hastings, Matthew B.

    2017-04-01

    The quantum max-flow min-cut conjecture relates the rank of a tensor network to the minimum cut in the case that all tensors in the network are identical in Calegari et al. (J Am Math Soc 23(1):107-188, 2010). This conjecture was shown to be false in Cui et al. (J Math Phys 57:062206, 2016) by an explicit counter-example. Here, we show that the conjecture is almost true, in that the ratio of the quantum max-flow to the quantum min-cut converges to 1 as the dimension N of the degrees of freedom on the edges of the network tends to infinity. The proof is based on estimating moments of the singular values of the network. We introduce a generalization of "rainbow diagrams" to tensor networks to estimate the dominant diagrams. A direct comparison of second and fourth moments lower bounds the ratio of the quantum max-flow to the quantum min-cut by a constant. To show the tighter bound that the ratio tends to 1, we consider higher moments. In addition, we show that the limiting moments as N → ∞ agree with that in a different ensemble where tensors in the network are chosen independently; this is used to show that the distributions of singular values in the two different ensembles weakly converge to the same limiting distribution. We present also a numerical study of one particular tensor network, which shows a surprising dependence of the rank deficit on N mod 4 and suggests further conjecture on the limiting behavior of the rank.

  8. NMR of 129Xe on CO/Ir(1 1 1) and on multilayer Xe/Ir(1 1 1)

    NASA Astrophysics Data System (ADS)

    Koch, Matthias; Gerhard, Peter; Jänsch, Heinz J.

    2006-09-01

    Nuclear magnetic resonance (NMR) is performed on monolayer (ML) amounts of adsorbed 129Xe on a single crystal substrate. The inherently low sensitivity of NMR is overcome by using highly nuclear spin polarized 129Xe that has been produced by optical pumping. A polarization of 0.8 is regularly achieved which is 10 5 times the thermal (Boltzmann) polarization. The experiments are performed with a constant flux of xenon atoms impinging on the surface, typically 4 ML/s. The chemical shift ( σ) of 129Xe is highly sensitive to the Xe local environment. We measured profoundly different shifts for the Xe bulk, for the surface of the Xe bulk, and for Xe on CO/Ir(1 1 1). The growth of the bulk is seen in a phase transition like change of σ as a function of temperature at constant Xe flux. At temperatures where no bulk forms at a flux of 4 ML/s, the xenon exchange rate was measured by a spin inversion/recovery method. The exchange time of Xe is found to be 0.24 s at 63.4 K and 64.4 K and somewhat longer at 61.2 K. An analysis is given involving the desorption out of the second layer and fast mixing of first and second layer atoms at these temperatures.

  9. Neurofibromatosis type 1

    PubMed Central

    Boyd, Kevin P.; Korf, Bruce R.; Theos, Amy

    2009-01-01

    Neurofibromatosis type 1 (NF1) is an autosomal dominant, multisystem disorder affecting approximately 1 in 3500 people. Significant advances in the understanding of the pathophysiology of NF1 have been made in the last decade. While no medical therapies are currently available, trials are ongoing to discover and test medical treatments for the various manifestations of NF1, primarily plexiform neurofibromas, learning disabilities, and optic pathway gliomas. Additionally, mutational analysis has become available on a clinical basis and is useful for diagnostic confirmation in individuals who do not fulfill diagnostic criteria or when prenatal diagnosis is desired. There are several disorders which may share overlapping features with NF1; in 2007, a disorder with cutaneous findings similar to NF1 was described. This paper addresses the dermatologist's role in diagnosis and management of NF1 and describes the variety of cutaneous and extracutaneous findings in NF1 to which the dermatologist may be exposed. PMID:19539839

  10. CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms

    PubMed Central

    Fernandes, Glaucia Maria M; Russo, Anelise; Proença, Marcela Alcântara; Gazola, Nathalia Fernanda; Rodrigues, Gabriela Helena; Biselli-Chicote, Patrícia Matos; Silva, Ana Elizabete; Netinho, João Gomes; Pavarino, Érika Cristina; Goloni-Bertollo, Eny Maria

    2016-01-01

    AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer (SCRC) risk. METHODS Six hundred forty-one individuals (227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1*2A, CYP1A1*2C CYP2E1*5B and CYP2E1*6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The EPHX1 Tyr113His, EPHX1 His139Arg and CYP1A1*2C polymorphisms were detected by real-time PCR. Chi-squared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version 2.05. RESULTS Age over 62 years was a risk factor for SCRC development (OR = 7.54, 95%CI: 4.94-11.50, P < 0.01). Male individuals were less susceptible to SCRC (OR = 0.55, 95%CI: 0.35-0.85, P < 0.01). The CYP2E1*5B polymorphism was associated with SCRC in the codominant (heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, P < 0.01), dominant (OR = 2.82, 95%CI: 1.74-4.55, P < 0.01), overdominant (OR = 2.58, 95%CI: 1.59-4.19, P < 0.01), and log-additive models (OR = 2.84, 95%CI: 1.78-4.52, P < 0.01). The CYP2E1*6 polymorphism was associated with an increased SCRC risk in codominant (heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, P < 0.01; homozygous polymorphic: OR = 7.32, 95%CI: 1.85-28.96, P < 0.01), dominant (OR = 2.97, 95%CI: 1.97-4.50, P < 0.01), recessive (OR = 5.26, 95%CI: 1.35-20.50, P = 0.016), overdominant (OR = 2.64, 95%CI: 1.74-4.01, P < 0.01), and log-additive models (OR = 2.78, 95%CI: 1.91-4.06, P < 0.01). The haplotype formed by the minor alleles of the CYP2E1*5B (C) and CYP2E1*6 (A) polymorphisms was associated with SCRC (P = 0.002). However, the CYP1A1*2A, CYP1A1*2C, EPHX1 Tyr113His and EPHX1 His139Arg polymorphisms were not associated with SCRC. CONCLUSION In conclusion, the

  11. Adolescents with clinical type 1 diabetes display reduced red blood cell glucose transporter isoform 1 (GLUT1).

    PubMed

    Garg, Meena; Thamotharan, Manikkavasagar; Becker, Dorothy J; Devaskar, Sherin U

    2014-11-01

    Type 1 diabetic (T1D) adolescent children on insulin therapy suffer episodes of both hyper- and hypoglycemic episodes. Glucose transporter isoform GLUT1 expressed in blood-brain barrier (BBB) and red blood cells (RBC) compensates for perturbed circulating glucose toward protecting the supply to brain and RBCs. We hypothesized that RBC-GLUT1 concentration, as a surrogate for BBB-GLUT1, is altered in T1D children. To test this hypothesis, we measured RBC-GLUT1 by enzyme-linked immunosorbent assay (ELISA) in T1D children (n = 72; mean age 15.3 ± 0.2 yr) and control children (CON; n = 11; mean age 15.6 ± 0.9 yr) after 12 h of euglycemia and during a hyperinsulinemic-hypoglycemic clamp with a nadir blood glucose of ~3.3 mmol/L for 90 min (clamp I) or ~3 mmol/L for 45 min (clamp II). Reduced baseline RBC-GLUT1 was observed in T1D (2.4 ± 0.17 ng/ng membrane protein); vs. CON (4.2 ± 0.61 ng/ng protein) (p < 0.0001). Additionally, baseline RBC-GLUT1 in T1D negatively correlated with hemoglobin A1c (HbA1c) (R = -0.23, p < 0.05) but not in CON (R = 0.06, p < 0.9). Acute decline in serum glucose to 3.3 mmol/L (90 min) or 3 mmol/L (45 min) did not change baseline RBC-GLUT1 in T1D or CON children. We conclude that reduced RBC-GLUT1 encountered in T1D, with no ability to compensate by increasing during acute hypoglycemia over the durations examined, may demonstrate a vulnerability of impaired RBC glucose transport (serving as a surrogate for BBB), especially in those with the worst control. We speculate that this may contribute to the perturbed cognition seen in T1D adolescents.

  12. 26 CFR 1.1083-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... company systems.* * * (b) It shall be the duty of the Commission, as soon as practicable after January 1... proper functioning of such system or systems. (2) To require by order, after notice and opportunity for... structure, or unfairly or inequitably distribute voting power among security holders, of such...

  13. Skylab 1 (1/2) sensitometric summary

    NASA Technical Reports Server (NTRS)

    Weinstein, M. S.

    1973-01-01

    Sensitometric data obtained from all rolls of Skylab 1 original film containing sensitometric exposures applied by the Photographic Technology Division are presented. A summary is provided that identifies the supply and take-up magazine numbers, the amount of radiation, and the change in Dmax or Base + Fog due to heat and radiation for each roll of original film.

  14. 26 CFR 1.1275-1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... chosen by A (the annuity starting date), X will begin equal monthly distributions for A's life. The... beginning on March 1, 1999, X will distribute to B a fixed amount of cash each month for B's life. Based on...), X will begin equal monthly distributions for C's life. The amount of each monthly distribution...

  15. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... more than slight or momentary pain or distress in a human being to which that procedure was applied... uses or intends to use live animals in research, tests, or experiments, and that (1) purchases or..., or experiments: Provided, That the Administrator may exempt, by regulation, any such...

  16. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... more than slight or momentary pain or distress in a human being to which that procedure was applied... uses or intends to use live animals in research, tests, or experiments, and that (1) purchases or..., or experiments: Provided, That the Administrator may exempt, by regulation, any such...

  17. New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne.

    PubMed

    Spiteri, Christian; Keeling, Steve; Moses, John E

    2010-08-06

    A new synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min, affording the corresponding N(1)-C(3) disubstituted indazoles in moderate to excellent yields.

  18. On MaxMin and MinMax Strategies in Multi-Stage Games and ATACM

    DTIC Science & Technology

    1976-08-01

    of the computation of MaxMin and MinMax strategies in multi-stage games. A new method for finding Max- Min and MinMax strategies for one-stage... Methods for finding decisions that in some sense optimize the payoff are sought; traditionally, an equilibrium point in randomized strategies has been...As a result the total running time is greatly reduced from previous versions. This method can be adapted to find MaxMin and MinMax strategies of

  19. Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid: Mechanism of Decomposition and Inhibition of 1-Aminocyclopropane-1-carboxylic Acid Deaminase.

    PubMed

    Liu, Cheng-Hao; Wang, Shao-An; Ruszczycky, Mark W; Chen, Huawei; Li, Keqiang; Murakami, Kazuo; Liu, Hung-wen

    2015-07-02

    1-Amino-2,2-difluorocyclopropane-1-carboxylic acid (DFACC) is of interest in the study of 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase due to the increased reactivity of its cyclopropyl functionality. It is shown that DFACC is unstable under near-physiological conditions where it primarily decomposes via specific-base catalysis to 3-fluoro-2-oxobut-3-enoic acid with a rate constant of 0.18 ± 0.01 min(-1). Upon incubation with ACC deaminase, DFACC is found to be a slow-dissociating inhibitor of ACC deaminase with submicromolar affinity.

  20. Early cardiology assessment and intervention reduces mortality following myocardial injury after non-cardiac surgery (MINS)

    PubMed Central

    Hua, Alina; Pattenden, Holly; Leung, Maria; Davies, Simon; George, David A.; Raubenheimer, Hilgardt; Niwaz, Zakiyah

    2016-01-01

    Background Myocardial injury after non-cardiac surgery (MINS) is defined as troponin elevation of ≥0.03 ng/mL associated with 3.87-fold increase in early mortality. We sought to determine the impact of cardiology intervention on mortality in patients who developed MINS after general thoracic surgery. Methods A retrospective review was performed in patients over 5 years. Troponin was routinely measured and levels ≥0.04 ng/mL classified as positive. Data acquisition and mortality status was obtained via medical records and NHS tracing systems. Thirty-day mortality was compared on MINS cohort using Fisher’s exact square testing and logistic regression analysis. Results Troponin levels were measured in 491 (96%) of 511 patients. Eighty (16%) patients fulfilled the MINS criteria. Sixty-one (76%) received early cardiology consult and “myocardial infarction” stated in four (5%) patients. Risk assessment (for AMI) was undertaken; 20 (25%) patients were commenced on aspirin, four (5%) on β-blockers and one (1%) underwent percutaneous coronary intervention. Forty-nine (61%) patients received primary risk factor modifications and 26 (33%) had outpatient follow-up. There were no significant differences in the proportion of patients who died within 30 days post-operatively in the MINS group of 2.6% compared to the non-MINS group of 1.6% (P=0.625). The odds ratio for 30-day mortality in the MINS group was 1.69 (95% CI: 0.34 to 8.57, P=0.522). Conclusions MINS is common after general thoracic surgery. Early cardiology intervention reduced the expected hazard ratio of early death from 3.87 to an odds ratio of 1.69 with no significant difference in 30-day mortality for patients who developed MINS. PMID:27162667

  1. CCF Experiment #1

    NASA Video Gallery

    Images from CCF camera during Experiment #1, or EU#1, square groove geometry operations. The free surface, or gas/liquid interface, assumes a curved shape under subcritical flow conditions as its m...

  2. Microhydropower Handbook, Volume 1, Part 1

    SciTech Connect

    McKinney, J.D.

    1983-01-01

    The purpose of the “Microhydropower Handbook, Volume 1, Part 1” is to provide a mechanically proficient lay person with sufficient information to evaluate microhydropower site potential, lay out a site, select and install equipment, and finally, operate and maintain the completed system. The actual construction details of the site are not included; rather, pointers are given as to what help an individual should expect from a construction contractor, and general guidelines on construction details are provided. In addition, information about obtaining financing and permits is provided. To help offset cost, the person performing the work, referred to as the “developer,” is encouraged to do as much of the work as possible. However, developers with major areas of uncertainty should consider professional assistance.

  3. BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).

    PubMed

    Agsten, Marianne; Hessler, Sabine; Lehnert, Sandra; Volk, Tilmann; Rittger, Andrea; Hartmann, Stephanie; Raab, Christian; Kim, Doo Yeon; Groemer, Teja W; Schwake, Michael; Alzheimer, Christian; Huth, Tobias

    2015-12-01

    KCNQ1 (Kv7.1) proteins form a homotetrameric channel, which produces a voltage-dependent K(+) current. Co-assembly of KCNQ1 with the auxiliary β-subunit KCNE1 strongly up-regulates this current. In cardiac myocytes, KCNQ1/E1 complexes are thought to give rise to the delayed rectifier current IKs, which contributes to cardiac action potential repolarization. We report here that the type I membrane protein BACE1 (β-site APP-cleaving enzyme 1), which is best known for its detrimental role in Alzheimer's disease, but is also, as reported here, present in cardiac myocytes, serves as a novel interaction partner of KCNQ1. Using HEK293T cells as heterologous expression system to study the electrophysiological effects of BACE1 and KCNE1 on KCNQ1 in different combinations, our main findings were the following: (1) BACE1 slowed the inactivation of KCNQ1 current producing an increased initial response to depolarizing voltage steps. (2) Activation kinetics of KCNQ1/E1 currents were significantly slowed in the presence of co-expressed BACE1. (3) BACE1 impaired reconstituted cardiac IKs when cardiac action potentials were used as voltage commands, but interestingly augmented the IKs of ATP-deprived cells, suggesting that the effect of BACE1 depends on the metabolic state of the cell. (4) The electrophysiological effects of BACE1 on KCNQ1 reported here were independent of its enzymatic activity, as they were preserved when the proteolytically inactive variant BACE1 D289N was co-transfected in lieu of BACE1 or when BACE1-expressing cells were treated with the BACE1-inhibiting compound C3. (5) Co-immunoprecipitation and fluorescence recovery after photobleaching (FRAP) supported our hypothesis that BACE1 modifies the biophysical properties of IKs by physically interacting with KCNQ1 in a β-subunit-like fashion. Strongly underscoring the functional significance of this interaction, we detected BACE1 in human iPSC-derived cardiomyocytes and murine cardiac tissue and observed

  4. Horizontally separated 1-in-1 crossing insertions

    SciTech Connect

    Syphers, M.J.

    1985-10-01

    Previous to this workshop, realistic lattices have been developed for vertically separated l-in-l (e.g., D.E. Johnson, A.A. Garren) and 2-in-1 (e.g., S. Heifets) magnets as well as for horizontally separated 2-in-l magnets (e.g., SSC RDS). Bringing together the widely separated ({approximately}60-70 cm) beams in a reasonable length of tunnel and keeping the dispersion zero at the interaction point has been difficult in the vertical l-in-l case. Most designs have required spacial 2-in-1 quadrupoles near the interaction point where the beams are separated by 15 cm or less. It is not clear that such magnets, as dictated by some of these lattice designs, can easily be built. The purpose of this exercise is to provide a crossing insertion for a realistic lattice which involves horizontally separated l-in-l magnets. The following horizontal crossing insertions, which incorporate the dispersion suppressors and phase trombones into the major arcs, need no special 2-in-1 magnets near the interaction point. The dispersion at the IP created by the horizontal crossing can be cancelled by the dispersion suppressor and one set of triplets.

  5. Psychoneuroimmunology and HIV-1.

    ERIC Educational Resources Information Center

    Antoni, Michael H.; And Others

    1990-01-01

    Presents evidence describing benefits of behavioral interventions such as aerobic exercise training on both psychological and immunological functioning among high risk human immunodeficiency virus-Type 1 (HIV-1) seronegative and very early stage seropositive homosexual men. HIV-1 infection is cast as chronic disease for which early…

  6. H-1 Engine

    NASA Technical Reports Server (NTRS)

    1960-01-01

    Alignment of the H-1 engine performed in the Army Ballistic Missile Agency (ABMA ), building 4708, in February 1960. A cluster of eight H-1 engines were used to thrust the first stage of the Saturn I launch vehicle. The H-1 engine was developed under the direction of the Marshall Space Flight Center.

  7. H-1 Engines

    NASA Technical Reports Server (NTRS)

    1959-01-01

    The H-1 engines for the Saturn I vehicle in the alignment fixture. A cluster of eight H-1 engines were used to thrust the first stage of the Saturn I launch vehicle. The H-1 engine was developed under the direction of the Marshall Space Flight Center.

  8. MI1ANAV

    Atmospheric Science Data Center

    2014-09-03

    MI1ANAV MISR Level 1A Navigation Data: Reformatted Annotated Level 1A Product for the Navigation Data, which contains samples of the Terra Platform position and ... Specification Versioning History:  Engineering, Navigation SCAR-B Block:  SCAR-B ...

  9. Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin.

    PubMed

    Singleton, Patrick A; Dudek, Steven M; Chiang, Eddie T; Garcia, Joe G N

    2005-10-01

    Endothelial cell (EC) barrier dysfunction results in increased vascular permeability observed in inflammation, tumor angiogenesis, and atherosclerosis. The platelet-derived phospholipid sphingosine-1-phosphate (S1P) decreases EC permeability in vitro and in vivo and thus has obvious therapeutic potential. We examined S1P-mediated human pulmonary artery EC signaling and barrier regulation in caveolin-enriched microdomains (CEM). Immunoblotting from S1P-treated EC revealed S1P-mediated rapid recruitment (1 microM, 5 min) to CEMs of the S1P receptors S1P1 and S1P3, p110 PI3 kinase alpha and beta catalytic subunits, the Rac1 GEF, Tiam1, and alpha-actinin isoforms 1 and 4. Immunoprecipitated p110 PI3 kinase catalytic subunits from S1P-treated EC exhibited PIP3 production in CEMs. Immunoprecipitation of S1P receptors from CEM fractions revealed complexes containing Tiam1 and S1P1. PI3 kinase inhibition (LY294002) attenuated S1P-induced Tiam1 association with S1P1, Tiam1/Rac1 activation, alpha-actinin-1/4 recruitment, and EC barrier enhancement. Silencing of either S1P1 or Tiam1 expression resulted in the loss of S1P-mediated Rac1 activation and alpha-actinin-1/4 recruitment to CEM. Finally, silencing S1P1, Tiam1, or both alpha-actinin isoforms 1/4 inhibits S1P-induced cortical F-actin rearrangement and S1P-mediated barrier enhancement. Taken together, these results suggest that S1P-induced recruitment of S1P1 to CEM fractions promotes PI3 kinase-mediated Tiam1/Rac1 activation required for alpha-actinin-1/4-regulated cortical actin rearrangement and EC barrier enhancement.

  10. The Ufm1 Cascade

    PubMed Central

    Daniel, Jens; Liebau, Eva

    2014-01-01

    The ubiquitin-fold modifier 1 (Ufm1) is a posttranslational modifier that belongs to the ubiquitin-like protein (UBL) family. Ufm1 is present in nearly all eukaryotic organisms, with the exception of fungi. It resembles ubiquitin in its ability to be ligated to other proteins, as well as in the mechanism of ligation. While the Ufm1 cascade has been implicated in endoplasmic reticulum functions and cell cycle control, its biological role still remains poorly understood. In this short review, we summarize the current state of Ufm1 research and its potential role in human diseases, like diabetes, ischemic heart disease and cancer. PMID:24921187

  11. The E1 proteins

    SciTech Connect

    Bergvall, Monika; Melendy, Thomas; Archambault, Jacques

    2013-10-15

    E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structural studies have revealed the assembly pathway of E1 at the origin and how the enzyme unwinds DNA using a spiral escalator mechanism. E1 is tightly regulated in vivo, in particular by post-translational modifications that restrict its accumulation in the nucleus. Here we review how different functional domains of E1 orchestrate viral DNA replication, with an emphasis on their interactions with substrate DNA, host DNA replication factors and modifying enzymes. These studies have made E1 one of the best characterized helicases and provided unique insights on how PVs usurp different host-cell machineries to replicate and amplify their genome in a tightly controlled manner. - Highlights: • The papillomavirus E1 helicase orchestrates replication of the viral DNA genome. • E1 assembles into a double-hexamer at the viral origin with the help of E2. • E1 interacts with cellular DNA replication factors. • E1 unwinds DNA using a spiral escalator mechanism. • Nuclear accumulation of E1 is regulated by post-translational modifications.

  12. Collagenase Total Occlusion-1 (CTO-1) Trial

    PubMed Central

    Strauss, Bradley H.; Osherov, Azriel B.; Radhakrishnan, Sam; Mancini, G.B. John; Manners, Allison; Sparkes, John D.; Chisholm, Robert J.

    2014-01-01

    Background Percutaneous interventions for chronic total occlusions have low success rates, primarily because of failure of guide wire crossing. Collagen-rich matrix constitutes the main barrier to chronic total occlusion crossing. In preclinical studies, local delivery of a bacterial collagenase formulation improved guide wire crossing. The Collagenase Total Occlusion-1 (CTO-1) Trial is a phase I, dose-escalation trial to assess the safety and efficacy of collagenase therapy to facilitate guide wire crossing in coronary artery chronic occlusions. Methods and Results Twenty subjects with ≥1 previous failure of chronic total occlusion guide wire crossing were enrolled at 2 sites. Subjects were treated in 4 distinct cohorts of 5 patients, with escalation of collagenase dose in each cohort from 300 to 1200 μg. Collagenase was locally delivered into the occlusions with either an over-the-wire balloon system (n=8) or a fine-cross microcatheter (n=12) for a period of 30 minutes. Subjects were brought back to the catheterization laboratory for guide wire crossing and angioplasty the next day. Guide wire crossing was successfully achieved in 15 subjects (75%). A soft-tip guide wire (Whisper, Pilot-50, Fielder XT) was either the sole or predominant guide wire used in 75% of successful crossings. Non–ST-segment–elevation myocardial infarctions occurred in 3 patients as a result of side-branch ischemia during stenting. Computed tomographic angiography at 3 months showed no late complications and patent stents in successfully treated chronic total occlusion. Anginal improvement occurred with a reduction in Canadian Cardiovascular Society class from baseline to 3 months (2.5±0.6 versus 0.9±0.9; P<0.001). Conclusion Local delivery of collagenase into coronary chronic total occlusion is feasible and safe with encouraging guide wire crossing results in previously failed cases. Larger clinical trials are required to determine efficacy. Clinical Trial Registration URL: http

  13. SAF1. Standard Agent Framework 1

    SciTech Connect

    Goldsmith, S.Y

    1997-06-01

    The Standard Agent framework provides an extensible object-oriented development environment suitable for use in both research and applications projects. The SAF provides a means for constructing and customizing multi-agent systems through specialization of standard base classes (architecture-driven framework) and by composition of component classes (data driven framework). The standard agent system is implemented as an extensible object-centerd framework. Four concrete base classes are developed: (1) Standard Agency; (2) Standard Agent; (3) Human Factor, and (4) Resources. The object-centered framework developed and utilized provides the best comprimise between generality and flexibility available in agent development systems today.

  14. Strategic Studies Quarterly. Volume 1, Number 1

    DTIC Science & Technology

    2007-09-01

    Balance to the Influence of Clausewitz Philip jS lt.ilin tzr’ 20070905614 Chief of Staff, US Air Force GeniT Miclich ( Mtos ele Com~mander, Air...International Studies. STRKT[GI STUD [ Q1,& ,v * F.,.i 2007 [79 ] .Jefiy Record force? Is the war laying the foundations for an "Iraq syndrome ...34 analogous to the "Vietnam syndrome "? Does the Iraq War vindicate the "realist" for- eign policy’s rejection of using force to promote the expansion of Ameri

  15. Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer.

    PubMed

    Van Emburgh, Beth O; Hu, Jennifer J; Levine, Edward A; Mosley, Libyadda J; Perrier, Nancy D; Freimanis, Rita I; Allen, Glenn O; Rubin, Peter; Sherrill, Gary B; Shaw, Cindy S; Carey, Lisa A; Sawyer, Lynda R; Miller, Mark Steven

    2008-05-01

    Polymorphisms in the cytochrome P450 1B1 (CYP1B1) and glutathione S-transferase (GST) drug metabolic enzymes, which are responsible for metabolic activation/detoxification of estrogen and environmental carcinogens, were analyzed for their association with breast cancer risk in 541 cases and 635 controls from a North Carolina population. Each polymorphism, altering the catalytic function of their respective enzymes, was analyzed in Caucasian and African-American women. As reported in previous studies, individual polymorphisms did not significantly impact breast cancer risk in either Caucasian or African-American women. However, African-American women exhibited a trend towards a protective effect when they had at least one CYP1B1 119S allele (OR=0.53; 95% CI=0.20-1.40) and increased risk for those women harboring at least one CYP1B1 432V allele (OR=5.52; 95% CI=0.50-61.37). Stratified analyses demonstrated significant interactions in younger (age < or =60) Caucasian women with the CYP1B1 119SS genotype (OR=3.09; 95% CI=1.22-7.84) and younger African-American women with the GSTT1 null genotype (OR=4.07; 95% CI=1.12-14.80). A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02-4.41). In Caucasian women, the combined GSTP1 105IV/VV and CYP1B1 119AA genotypes resulted in a near 2-fold increase in risk (OR=1.96; 95% CI=1.04-3.72) and the three way combination of GSTP1 105IV/VV, CYP1B1 119AS/SS and GSTT1 null genotypes resulted in an almost 4-fold increase in risk (OR=3.97; 95% CI=1.27-12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation.

  16. Polymorphisms in CYP1B1, GSTM1, GSTT1 and GSTP1, and susceptibility to breast cancer

    PubMed Central

    Van Emburgh, Beth O.; Hu, Jennifer J.; Levine, Edward A.; Mosley, Libyadda J.; Perrier, Nancy D.; Freimanis, Rita I.; Allen, Glenn O.; Rubin, Peter; Sherrill, Gary B.; Shaw, Cindy S.; Carey, Lisa A.; Sawyer, Lynda R.; Miller, Mark Steven

    2013-01-01

    Polymorphisms in the cytochrome P450 1B1 (CYP1B1) and glutathione S-transferase (GST) drug metabolic enzymes, which are responsible for metabolic activation/detoxification of estrogen and environmental carcinogens, were analyzed for their association with breast cancer risk in 541 cases and 635 controls from a North Carolina population. Each polymorphism, altering the catalytic function of their respective enzymes, was analyzed in Caucasian and African-American women. As reported in previous studies, individual polymorphisms did not significantly impact breast cancer risk in either Caucasian or African-American women. However, African-American women exhibited a trend towards a protective effect when they had at least one CYP1B1 119S allele (OR=0.53; 95% CI=0.20–1.40) and increased risk for those women harboring at least one CYP1B1 432V allele (OR=5.52; 95% CI=0.50–61.37). Stratified analyses demonstrated significant interactions in younger (age ≤60) Caucasian women with the CYP1B1 119SS genotype (OR=3.09; 95% CI=1.22–7.84) and younger African-American women with the GSTT1 null genotype (OR=4.07; 95% CI=1.12–14.80). A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02–4.41). In Caucasian women, the combined GSTP1 105IV/VV and CYP1B1 119AA genotypes resulted in a near 2-fold increase in risk (OR=1.96; 95% CI=1.04–3.72) and the three way combination of GSTP1 105IV/VV, CYP1B1 119AS/SS and GSTT1 null genotypes resulted in an almost 4-fold increase in risk (OR=3.97; 95% CI=1.27–12.40). These results suggest the importance of estrogen/carcinogen metabolic enzymes in the etiology of breast cancer, especially in women before the age of 60, as well as preventative measures such as smoking cessation. PMID:18425393

  17. SGK1 dependence of insulin induced hypokalemia.

    PubMed

    Boini, Krishna M; Graf, Dirk; Kuhl, Dietmar; Häussinger, Dieter; Lang, Florian

    2009-02-01

    Insulin stimulates cellular K+ uptake leading to hypokalemia. Cellular K+ uptake is accomplished by parallel stimulation of Na+/H+ exchange, Na+,K+,2Cl- co-transport, and Na+/K+ ATPase and leads to cell swelling, a prerequisite for several metabolic effects of the hormone. Little is known about underlying signaling. Insulin is known to activate the serum and glucocorticoid-inducible kinase SGK1, which in turn enhances the activity of all three transport proteins. The present study thus explored the contribution of SGK1 to insulin-induced hypokalemia. To this end, gene-targeted mice lacking SGK1 (sgk1-/-) and their wild-type littermates (sgk1+/+) have been infused with insulin (2 mU kg(-1) min(-1)) and glucose at rates leaving the plasma glucose concentration constant. Moreover, isolated liver perfusion experiments have been performed to determine stimulation of cellular K+ uptake by insulin (100 nM). As a result, combined glucose and insulin infusion significantly decreased plasma K+ concentration despite a significant decrease of urinary K+ excretion in sgk1+/+ but not in sgk1-/- mice. Accordingly, the plasma K+ concentration was within 60 min significantly lower in sgk1+/+ than in sgk1-/- mice. In isolated liver perfusion experiments, cellular K+ uptake was stimulated by insulin (100 nM), an effect blunted by 72% in sgk1-/- mice as compared to sgk1+/+ mice. Accordingly, insulin-induced cell hydration was 63% lower in sgk1-/- mice than in sgk1+/+ mice. Moreover, volume regulatory K+ release was 31% smaller in sgk1-/- mice than in sgk1+/+ mice. In conclusion, the serum and glucocorticoid-inducible kinase SGK1 participates in the signaling mediating the hypokalemic effect of insulin.

  18. 4-Carboxypiperidinium 1-carboxycyclobutane-1-carboxylate.

    PubMed

    Belandria, Lusbely M; Mora, Asiloé J; Delgado, Gerzon E; Briceño, Alexander

    2012-02-01

    The title salt, C(6)H(12)NO(2)(+)·C(6)H(7)O(4)(-) or ISO(+)·CBDC(-), is an ionic ensemble assisted by hydrogen bonds. The amino acid moiety (ISO or piperidine-4-carboxylic acid) has a protonated ring N atom (ISO(+) or 4-carboxypiperidinium), while the semi-protonated acid (CBDC(-) or 1-carboxycyclobutane-1-carboxylate) has the negative charge residing on one carboxylate group, leaving the other as a neutral -COOH group. The -(+)NH(2)- state of protonation allows the formation of a two-dimensional crystal packing consisting of zigzag layers stacked along a separated by van der Waals distances. The layers extend in the bc plane connected by a complex network of N-H···O and O-H···O hydrogen bonds. Wave-like ribbons, constructed from ISO(+) and CBDC(-) units and described by the graph-set symbols C(3)(3)(10) and R(3)(3)(14), run alternately in opposite directions along c. Intercalated between the ribbons are ISO(+) cations linked by hydrogen bonds, forming rings described by the graph-set symbols R(6)(6)(30) and R(4)(2)(18). A detailed analysis of the structures of the individual components and the intricate hydrogen-bond network of the crystal structure is given.

  19. (1+1)-dimensional separation of variables

    NASA Astrophysics Data System (ADS)

    Pucacco, Giuseppe; Rosquist, Kjell

    2007-11-01

    In this paper we explore general conditions which guarantee that the geodesic flow on a two-dimensional manifold with indefinite signature is locally separable. This is equivalent to showing that a two-dimensional natural Hamiltonian system on the hyperbolic plane possesses a second integral of motion which is a quadratic polynomial in the momenta associated with a secind rank Killing tensor. We examine the possibility that the integral is preserved by the Hamiltonian flow on a given energy hypersurface only (weak integrability) and derive the additional requirement necessary to have conservation at arbitrary values of the Hamiltonian (strong integrability). Using null coordinates, we show that the leading-order coefficients of the invariant are arbitrary functions of one variable in the case of weak integrability. These functions are quadratic polynomials in the coordinates in the case of strong integrability. We show that for (1+1)-dimensional systems, there are three possible types of conformal Killing tensors and, therefore, three distinct separability structures in contrast to the single standard Hamilton-Jacobi-type separation in the positive definite case. One of the new separability structures is the complex/harmonic type which is characterized by complex separation variables. The other new type is the linear/null separation which occurs when the conformal Killing tensor has a null eigenvector.

  20. Event generation with SHERPA 1.1

    SciTech Connect

    Gleisberg, T.; Hoche, Stefan.; Krauss, F.; Schoenherr, M.; Schumann, S.; Siegert, F.; Winter, J.

    2008-12-18

    In this paper the current release of the Monte Carlo event generator Sherpa, version 1.1, is presented. Sherpa is a general-purpose tool for the simulation of particle collisions at high-energy colliders. It contains a very flexible tree-level matrix-element generator for the calculation of hard scattering processes within the Standard Model and various new physics models. The emission of additional QCD partons off the initial and final states is described through a parton-shower model. To consistently combine multi-parton matrix elements with the QCD parton cascades the approach of Catani, Krauss, Kuhn and Webber is employed. A simple model of multiple interactions is used to account for underlying events in hadron-hadron collisions. The fragmentation of partons into primary hadrons is described using a phenomenological cluster-hadronization model. A comprehensive library for simulating tau-lepton and hadron decays is provided. Where available form-factor models and matrix elements are used, allowing for the inclusion of spin correlations; effects of virtual and real QED corrections are included using the approach of Yennie, Frautschi and Suura.

  1. Rule governing the division pattern in Escherichia coli minB and wild-type filaments.

    PubMed Central

    Jaffé, A; Boye, E; D'Ari, R

    1990-01-01

    Escherichia coli minB mutants form anucleate minicells and multinucleate filaments. We show here that the overwhelming majority of nucleate cells contain 2n (n = 0, 1, 2, ...) nucleoids, as determined by 4',6-diamidino-2-phenylindole staining, and 2n (n = 1, 2, 3, ...) copies of the replication origin, as determined by flow cytometry. This shows that division sites are not chosen randomly among the available sites in minB filaments. Similarly, wild-type cells contain 2n nucleoids, both during cell division inhibition and when furazlocillin-induced filaments are allowed to divide. We conclude that the min+ function is only to prevent septation only at polar sites; the placement of internal cell division sites must obey strict rules, which are the same in minB and wild-type cells. PMID:2188963

  2. X-1 in flight

    NASA Technical Reports Server (NTRS)

    1947-01-01

    The Bell Aircraft Corporation X-1-1 (#46-062) in flight. The shock wave pattern in the exhaust plume is visible. The X-1 series aircraft were air-launched from a modified Boeing B-29 or a B-50 Superfortress bombers. The X-1-1 was painted a bright orange by Bell Aircraft. It was thought that the aircraft would be more visable to those doing the tracking during a flight. When NACA received the airplanes they were painted white, which was an easier color to find in the skies over Muroc Air Field in California. This particular craft was nicknamed 'Glamorous Glennis' by Chuck Yeager in honor of his wife, and is now on permanent display in the Smithsonian Institution's National Air and Space Museum in Washington, DC. There were five versions of the Bell X-1 rocket-powered research aircraft that flew at the NACA High-Speed Flight Research Station, Edwards, California. The bullet-shaped X-1 aircraft were built by Bell Aircraft Corporation, Buffalo, N.Y. for the U.S. Army Air Forces (after 1947, U.S. Air Force) and the National Advisory Committee for Aeronautics (NACA). The X-1 Program was originally designated the XS-1 for EXperimental Sonic. The X-1's mission was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' Three different X-1s were built and designated: X-1-1, X-1-2 (later modified to become the X-1E), and X-1-3. The basic X-1 aircraft were flown by a large number of different pilots from 1946 to 1951. The X-1 Program not only proved that humans could go beyond the speed of sound, it reinforced the understanding that technological barriers could be overcome. The X-1s pioneered many structural and aerodynamic advances including extremely thin, yet extremely strong wing sections; supersonic fuselage configurations; control system requirements; powerplant compatibility; and cockpit environments. The X-1 aircraft were the first transonic-capable aircraft to use an all

  3. [NDM-1: the superbug?].

    PubMed

    Pittalis, S; Ferarro, F; Puro, V

    2011-12-01

    A novel type of carbapenemase, New Delhi metallo beta-lactamase 1 (NDM 1), was first identified in 2008 in two Enterobacteriacea isolates, both recovered from a Swedish patient transferred from India. The emergence of NDM 1 is now reported from all continents, often in patients with a history of travel or hospitalization in the Indian subcontinent. The NDM 1 producing Gram-negative bacteria are mainly Enterobacteriaceae, which can cause colonization or fatal infections, with worrying antimicrobial susceptibility profiles: some isolates have developed resistance to practically all available antibiotics. Is the NDM-1 the super-bug? Are we in the post-antibiotic era? This review is a summary of currently available knowledge of NDM-1 that draws attention to future antimicrobial resistance scenarios.

  4. Effect of PRX-1 Downregulation in the Type 1 Diabetes Microenvironment.

    PubMed

    Yoo, Jong-Sun; Lee, Yun-Jung; Hyung, Kyeong Eun; Yoon, Joo Won; Lee, Ik Hee; Park, So-Young; Hwang, Kwang Woo

    2012-12-01

    Type 1 diabetes (T1D) is caused by dysregulation of the immune system in the pancreatic islets, which eventually leads to insulin-producing pancreatic β-cell death and destabilization of glucose homeostasis. One of the major characteristics of T1D pathogenesis is the production of inflammatory mediators by macrophages that result in destruction or damage of pancreatic β-cells. In this study the inflammatory microenvironment of T1D was simulated with RAW264.7 cells and MIN6 cells, acting as macrophages and pancreatic β-cells respectably. In this setting, peroxiredoxin-1, an anti-oxidant enzyme was knocked down to observe its functions in the pathogenesis of T1D. RAW264.7 cells were primed with lipopolysaccharide and co-cultured with MIN6 cells while PRX-1 was knocked down in one or both cell types. Our results suggest that hindrance of PRX-1 activity or the deficiency of this enzyme in inflammatory conditions negatively affects pancreatic β-cell survival. The observed decrease in viability of MIN6 cells seems to be caused by nitric oxide production. Additionally, it seems that PRX-1 affects previously reported protective activity of IL-6 in pancreatic β cells as well. These results signify new, undiscovered roles for PRX-1 in inflammatory conditions and may contribute toward our understanding of autoimmunity.

  5. ANOS1: a unified nomenclature for Kallmann syndrome 1 gene (KAL1) and anosmin-1.

    PubMed

    de Castro, Fernando; Seal, Ruth; Maggi, Roberto

    2016-11-29

    It is accepted that confusion regarding the description of genetic variants occurs when researchers do not use standard nomenclature. The Human Genome Organization Gene Nomenclature Committee contacted a panel of consultants, all working on the KAL1 gene, to propose an update of the nomenclature of the gene, as there was a convention in the literature of using the 'KAL1' symbol, when referring to the gene, but using the name 'anosmin-1' when referring to the protein. The new name, ANOS1, reflects protein name and is more transferrable across species.

  6. TES Level 1B

    Atmospheric Science Data Center

    2014-12-08

    TES Level 1B data files contain radiometric calibrated spectral radiances and their ... and some engineering data are also provided. A Level 1B data file contains data from a single TES orbit for one focal ... as the Aura orbit number at the time of the South Pole apex crossing. version id represents the version identification number, ...

  7. A1C Test

    MedlinePlus

    ... eAG on their DiabetesPro web site . The NGSP web site also provides a calculator to convert hemoglobin A1c in SI units mmol/mol into percentage. ^ Back to top Is there anything else I should know? The A1c test will not reflect temporary, acute blood glucose increases ...

  8. A1C

    MedlinePlus

    A1C is a blood test for type 2 diabetes and prediabetes. It measures your average blood glucose, or blood sugar, level over the past 3 ... A1C alone or in combination with other diabetes tests to make a diagnosis. They also use the ...

  9. 1,3-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,3 - Dichlorobenzene ; CASRN 541 - 73 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinog

  10. 1,4-Dioxane

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 09 / 005 - F www.epa.gov / iris TOXICOLOGICAL REVIEW OF 1,4 - Dioxane ( CAS No . 123 - 91 - 1 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) August 2010 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has been rev

  11. Diabetes Type 1

    MedlinePlus

    Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is ... kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults ...

  12. 1,2-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,2 - Dichlorobenzene ; CASRN 95 - 50 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  13. PD-1 Blockers.

    PubMed

    Wolchok, Jedd D

    2015-08-27

    Nivolumab and pembrolizumab are monoclonal antibodies that block the programmed death-1 receptor (PD-1, CD279), resulting in dis-inhibition of tumor-specific immune responses. Both are recently approved for use in the treatment of metastatic melanoma, and nivolumab as well for non-small cell lung cancer.

  14. Sentinel-1 Instrument Overview

    NASA Astrophysics Data System (ADS)

    Snoeij, Paul; Torres, Ramon; Geudtner, Dirk; Brown, Michael; Deghaye, Patrick; Navas-Traver, Ignacio; Ostergaard, Allan; Rommen, Bjorn; Floury, Nicolas; Davidson, Malcolm

    2013-03-01

    The forthcoming European Space Agency (ESA) Sentinel-1 (S-1) C-band SAR constellation will provide continuous all-weather day/night global coverage, with six days exact repetition time (near daily coverage over Europe and Canada) and with radar data delivery within 3 to 24 hours. These features open new possibilities for operational maritime services. The Sentinel-1 space segment has been designed and is being built by an industrial consortium with Thales Alenia Space Italia as prime contractor and EADS Astrium GmbH as C-SAR instrument responsible. It is expected that Sentinel-1A be launched in 2013. This paper will provide an overview of the Sentinel-1 system, the status and characteristics of the technical implementation. The key elements of the system supporting the maritime user community will be highlighted.

  15. TELECOM 1 multiservices network

    NASA Astrophysics Data System (ADS)

    Lombard, D.; Ramat, P.; Rancy, F.

    The main objectives of the TELECOM 1 French domestic satellite project are to set up a business communication network which is to carry a wide range of digital services including data, voice, and pictures between a number of small earth stations located on the subscribers' premises. The parallel development of terrestrial specialized services networks has enabled the fitting of the TELECOM 1 network with high interworking capabilities with these networks. It has also allowed TELECOM 1 to be designed as the basis of the Future Integrated Services Digital Network. The TELECOM 1 network consists of the terrestrial network, the satellite network, and the maintenance network. Various elements which include the terrestrial network; the satellite network, and its modulation, TDMA frame and terminals; the System Management Center; the signalling system; and the demand assignment operation which are involved in the operation of the multiservices network are presented. The TELECOM 1 network evolution until 1990 through the rapid development of the ISDN is discussed.

  16. Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist.

    PubMed

    Cahalan, Stuart M; Gonzalez-Cabrera, Pedro J; Nguyen, Nhan; Guerrero, Miguel; Cisar, Elizabeth A George; Leaf, Nora B; Brown, Steven J; Roberts, Edward; Rosen, Hugh

    2013-02-01

    Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G protein-coupled receptor that is critical for proper lymphocyte development and recirculation. Agonists to S1P(1) are currently in use clinically for the treatment of multiple sclerosis, and these drugs may act on both S1P(1) expressed on lymphocytes and S1P(1) expressed within the central nervous system. Agonists to S1P(1) and deficiency in S1P(1) both cause lymphocyte sequestration in the lymph nodes. In the present study, we show that S1P(1) antagonism induces lymphocyte sequestration in the lymph nodes similar to that observed with S1P(1) agonists while upregulating S1P(1) on lymphocytes and endothelial cells. Additionally, we show that S1P(1) antagonism reverses experimental autoimmune encephalomyelitis in mice without acting on S1P(1) expressed within the central nervous system, demonstrating that lymphocyte sequestration via S1P(1) antagonism is sufficient to alleviate autoimmune pathology.

  17. Adsorption of dichlorodifluoromethane, chlorodifluoromethane, chloropentafluoroethane, 1,1-difluoroethane, and 1,1,1,2-tetrafluoroethane on silica gel

    SciTech Connect

    Frere, M.; Berlier, K.; Bougard, J.; Jadot, R. . Service de Thermodynamique)

    1994-10-01

    The CFC's (chlorofluorocarbons) are used as working refrigerants fluids. The most commonly used are R12, R22, and R502 (48.8% R22 and 51.2% R115). Recent concerns of the effects of CFC's on the ozone layer require the development of efficient recovery methods. One technique is to adsorb the fluids onto a porous medium such as silica gel. Thermodynamic data on the adsorption of dichlorodifluoromethane (R12), chlorodifluoromethane (R22), chloropentafluoroethane (R115), 1,1-difluoroethane (R152a), and 1,1,1,2-tetrafluoroethane (R134a) on silica gel are required for the design of recovery units. The results are presented here.

  18. Density functional theory study of SO2-adsorbed Ni(1 1 1) and hydroxylated NiO(1 1 1) surface

    NASA Astrophysics Data System (ADS)

    Wei, Xin; Dong, Chaofang; Chen, Zhanghua; Xiao, Kui; Li, Xiaogang

    2015-11-01

    Spin polarized, DFT + U periodic calculation is used as an effective way to model the adsorption process of SO2 on hydroxylated NiO(1 1 1) surface. The adsorption of atomic O and O2 on the clean Ni(1 1 1) surface is calculated to investigate the forming process of passive film. The molecular and dissociated adsorptions of H2O on NiO(1 1 1) surface are evaluated to construct defect-free hydroxylated NiO(1 1 1) surface. The adsorption of SO2 and atomic O on clean Ni(1 1 1) surface is also investigated to compare with the adsorption capacity between passive film and substrate. With respect to the single adsorption process of SO2 on defect-free hydroxylated NiO(1 1 1) surface, the effects of O vacancy of surface and atomic O closed to the surface are investigated. The calculation results show that there is no chemical adsorption of SO2 on the defect-free hydroxylated NiO(1 1 1) surface with or without atomic O. Either single SO2 or SO2 with atomic O prefer adsorbing on the hydroxylated NiO(1 1 1) surface with O vacancies. The adsorption behavior is strengthened with the increase of percentage of surface O vacancy. The existence of atomic O leads to the production of SO3 on the hydroxylated NiO(1 1 1) surface and strengthens the adsorption capacity of SO2. Furthermore, the results also reveal the relationship between the charge transfer and the adsorption energy of SO2 and atomic O on the hydroxylated NiO(1 1 1) surface and clean Ni(1 1 1) surface. We inferred that broken passive film susceptibility to corrosion compare with substrate when surface O vacancies aggregate and its concentration large enough.

  19. Air Remedial Investigation. Version 3.1. Volume 1

    DTIC Science & Technology

    1988-08-01

    Those compounds included: 5 acetone, siloxane, 1-ethyl-2-heptylcyclopropane, n-butyl-l-l-butanamine, 2- beta - pinene , limonene, 2,5,6-trimethyloctane...butanamine is also known as di-n- 3 butylamine. The compound 2- beta - pinene is a pine oil derivative and may be 3 4-10 I _- c b." I -’u+ U. >. I6 i~.4...1.0 INTRODUCTION 1-1 3 1.1 SITE RACKCROUND TNFORMATION I-1 1.2 NATURE AND EXTENT OF THE PROBLEM 1-3 1.2.1 CONTAMINANT SOURCES 1-3 1.2.1.1 qt Plant 1

  20. Human interleukin 1.

    PubMed

    Krakauer, T

    1986-01-01

    Interleukin 1 (IL-1), a product of stimulated monocytes or macrophages, is defined by its ability to enhance the response of thymocyte to mitogenic stimulation. Numerous studies attribute a multiplicity of other biological functions to IL-1 in immunological and inflammatory reactions. IL-1 also appears to be identical with endogenous pyrogen. Even though this mediator is produced in minute quantities and is active at very low concentrations, greatly complicating its purification, knowledge of its chemical structure and biochemical properties is rapidly increasing. The activity of human IL-1 is associated with multiple molecules of similar size, but subtly different compositions. Structure-function relations, most particularly the question of whether the functional diversity of IL-1 is a reflection of structural diversity or simply of diversity of target-cell responses to a single molecule can now be addressed, as the IL-1 components have been purified to homogeneity, on the one hand, and a precursor molecule, derived from a cloned cDNA sequence, has been obtained.

  1. Spacelab Life Sciences-1

    NASA Technical Reports Server (NTRS)

    Dalton, Bonnie P.; Jahns, Gary; Meylor, John; Hawes, Nikki; Fast, Tom N.; Zarow, Greg

    1995-01-01

    This report provides an historical overview of the Spacelab Life Sciences-1 (SLS-1) mission along with the resultant biomaintenance data and investigators' findings. Only the nonhuman elements, developed by Ames Research Center (ARC) researchers, are addressed herein. The STS-40 flight of SLS-1, in June 1991, was the first spacelab flown after 'return to orbit', it was also the first spacelab mission specifically designated as a Life Sciences Spacelab. The experiments performed provided baseline data for both hardware and rodents used in succeeding missions.

  2. BAP1 and Cancer

    PubMed Central

    Carbone, Michele; Yang, Haining; Pass, Harvey I.; Krausz, Thomas; Testa, Joseph R.; Gaudino, Giovanni

    2013-01-01

    Preface BAP1 is a deubiquitylase that is found associated with multi-protein complexes that regulate key cellular pathways, including the cell cycle, cellular differentiation, cell death, gluconeogenesis and the DNA damage response (DDR). Recent findings indicate that germline BAP1 mutations cause a novel cancer syndrome, characterized, at least in the affected families studied so far, by the onset at an early age of benign melanocytic skin tumours with mutated BAP1, and later in life by a high incidence of mesothelioma, uveal melanoma, cutaneous melanoma and possibly additional cancers. PMID:23550303

  3. 1-Benzyl-4-(naphthalen-1-yl)-1H-1,2,3-triazole

    PubMed Central

    Sarmiento-Sánchez, Juan I.; Aguirre, Gerardo; Rivero, Ignacio A.

    2011-01-01

    In the title compound, C19H15N3, the benzyl group is almost perpendicular to the triazole ring [dihedral angle = 80.64 (8)°], while the napthyl group makes an angle of 30.27 (12)° with the plane of the triazole ring. This conformation is different from the 1-benzyl-4-phenyl-1H-1,2,3-triazole analogue, which has the benzyl ring system at an angle of 87.94° and the phenyl group at an angle of 3.35° to the plane of the triazole ring. PMID:21837221

  4. The Paracaspase MALT1.

    PubMed

    Hachmann, Janna; Salvesen, Guy S

    2016-03-01

    The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB signaling. Over the past few years it has become clear that this is due to a combination of its scaffolding and proteolytic function. Knockout mice and mice expressing a catalytically dead variant of the protease have provided valuable information. This review aims to provide an overview of recent developments regarding the enzymatic mechanism and specificity of MALT1, its substrates discovered to date, different mouse models, as well as the role of MALT1 in NF-κB signaling downstream of a variety of different receptors.

  5. Viscosities and densities for heptane + 1-pentanol, + 1-hexanol, + 1-heptanol, + 1-octanol, + 1-decanol, and + 1-dodecanol at 298.15 K and 308.15 K

    SciTech Connect

    Sastry, N.V.; Valand, M.K.

    1996-11-01

    Densities and viscosities for heptane + 1-pentanol, + 1-hexanol, + 1-heptanol, + 1-octanol, + 1-decanol, and + 1-dodecanol are reported at (298.15 K and 308.15) K. The viscosity deviations were calculated. The mixture viscosity data were fitted to the semiempirical equations of Grunberg-Nissan, Heric, McAllister, and Auslander.

  6. DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease

    PubMed Central

    Suntharalingham, Jenifer P.; Buonocore, Federica; Duncan, Andrew J.; Achermann, John C.

    2016-01-01

    DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita. This condition typically affects boys and presents as primary adrenal insufficiency in early infancy or childhood, hypogonadotropic hypogonadism at puberty and impaired spermatogenesis. Late onset forms of this condition and variant phenotypes are increasingly recognized. In contrast, disruption of SF-1 only rarely causes adrenal insufficiency, usually in combination with testicular dysgenesis. Variants in SF-1/NR5A1 more commonly cause a spectrum of reproductive phenotypes ranging from 46,XY DSD (partial testicular dysgenesis or reduced androgen production) and hypospadias to male factor infertility or primary ovarian insufficiency. Making a specific diagnosis of DAX-1 or SF-1 associated conditions is important for long-term monitoring of endocrine and reproductive function, appropriate genetic counselling for family members, and for providing appropriate informed support for young people. PMID:26303087

  7. Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings.

    PubMed

    Ziesenitz, Victoria C; König, Sonja K; Mahlke, Nina; Jantos, Ricarda; Skopp, Gisela; Weiss, Johanna; Haefeli, Walter E; Mikus, Gerd

    2013-07-01

    A recent study investigating the pharmacokinetics of fentanyl in Sprague-Dawley rats suggested fentanyl to be a substrate of rat organic anion-transporting polypeptide Oatp. In human beings, the most important OATP for the pharmacokinetics of many drugs is OATP1B1. Therefore, genetic variants of OATP1B1 (SLCO1B1) might modulate fentanyl pharmacokinetics and efficacy in human beings. Sixteen healthy male and female volunteers, homozygous for SLCO1B1*1a (genetic wild-type) (n = 11) or *15 (deficient haplotype carrying the single-nucleotide polymorphisms rs2306283 and rs4149056 and exhibiting altered transport activity; n = 5), were included in this randomized crossover study. The participants received fentanyl (5 μg/kg) intravenously alone or with the OATP inhibitor rifampicin (600 mg single oral dose). The pharmacokinetics of fentanyl and norfentanyl were determined by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). In addition, fentanyl uptake in vitro was evaluated in OATP1B1 overexpressing HEK293 cells and compared to a mock-transfected cell line. In the clinical trial, fentanyl clearance was 18.8 ± 8.2 mL/min. kg in SLCO1B1*1a and 19.5 ± 1.8 mL/min/kg in SLCO1B1*15 carriers and not significantly different between the genotypes. During rifampicin, fentanyl clearance was 15.0 ± 4.4 mL/min/kg in SLCO1B1*1a and 16.7 ± 5.9 mL/min/kg in SLCO1B1*15 carriers (p > 0.5). In addition, in vitro data also indicate that fentanyl is not transported by OATP1B1. In conclusion, our data indicate that OATP1B1 has no impact on fentanyl pharmacokinetics in human beings.

  8. The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells.

    PubMed

    Brenner, Stefan; Riha, Juliane; Giessrigl, Benedikt; Thalhammer, Theresia; Grusch, Michael; Krupitza, Georg; Stieger, Bruno; Jäger, Walter

    2015-01-01

    The contribution of organic anion transporting polypeptides (OATPs) to the cellular uptake of flavopiridol was investigated in OATP1B1-, OATP1B3- and OATP2B1-expressing Chinese hamster ovary (CHO) cells. Uptake of flavopiridol into these cells showed typical Michaelis-Menten kinetics with much higher transport capacity for OATP1B3 compared to OATP1B1 and OATP2B1 (Vmax/Km, 33.9 vs. 8.84 and 2.41 µl/mg/min, respectively). The predominant role of OATPs was further supported by a dramatic inhibition of flavopiridol uptake in the presence of the OATP substrate rifampicin. Uptake of flavopiridol by OATPs also seems to be an important determinant in breast cancer cells. The much higher mRNA level for OATP1B1 found in wild-type compared to ZR-75-1 OATP1B1 knockdown cells correlated with higher flavopiridol initial uptake leading to 4.6-fold decreased IC50 values in the cytotoxicity assay (IC50, 1.45 vs. 6.64 µM). Cell cycle profile also showed a clear incidence for a stronger cell cycle arrest in the G2/M phase for ZR-75-1 wild-type cells compared to OATP1B1 knockdown cells, further indicating an active uptake via OATP1B1. In conclusion, our results revealed OATP1B1, OATP1B3 and OATP2B1 as uptake transporters for flavopiridol in cancer cells, which may also apply in patients during cancer therapy.

  9. Functional Analysis of Human NF1 in Drosophila

    DTIC Science & Technology

    2007-01-01

    protein (8). Further- more, acute expression of a wild-type Nf1 transgene in the mutant background, controlled by a heat - shock promoter (hsNf1; Nf1P2), was...activity (1 mM; t ¼ 30 min; n ¼ 4). (D) H-Ras stimulation of AC was eliminated in Nf1P1 and Nf1P2 mutant flies, and restored by heat - shock induced...strains and heat - shock conditions Flies were raised at room temperature (22–248C) on standard cornmeal medium. The Nf1 mutants Nf1P1 and Nf1P2, together

  10. X1 Exoskeleton

    NASA Video Gallery

    NASA's Ironman-Like Exoskeleton Could Give Astronauts, Paraplegics Improved Mobility and Strength. While NASA's X1 robotic exoskeleton can't do what you see in the movies, the latest robotic, space...

  11. C2H4ArF2 1,1-Difluoroethane - argon (1/1)

    NASA Astrophysics Data System (ADS)

    Demaison, J.

    This document is part of Part 1 of Subvolume D 'Asymmetric Top Molecules' of Volume 29 'Molecular Constants Mostly from Microwave, Molecular Beam, and Sub-Doppler Laser Spectroscopy' of Landolt-Börnstein - Group II 'Molecules and Radicals'.

  12. Probability 1/e

    ERIC Educational Resources Information Center

    Koo, Reginald; Jones, Martin L.

    2011-01-01

    Quite a number of interesting problems in probability feature an event with probability equal to 1/e. This article discusses three such problems and attempts to explain why this probability occurs with such frequency.

  13. Psychiatric liability: Part 1.

    PubMed

    Fiesta, J

    1998-07-01

    Psychiatric health care providers' liability extends from clinical cases--medication errors, misdiagnosis, etc.--to particular issues unique to the mental health setting. Part 1 discusses lawsuits common to this setting.

  14. Restructuring liability: Part 1.

    PubMed

    Fiesta, J

    1998-05-01

    With recent cutbacks in staffing, clarifying orders, establish priorities, understanding accepted standards and providing experienced personnel is even more critical. "Restructuring Liability: Part 1" discusses cases that focus on basic nursing skills--assessment, monitoring and communication.

  15. Alpha-1 Antitrypsin Deficiency

    MedlinePlus

    ... 1 antitrypsin (an-tee-TRIP-sin) deficiency, or AAT deficiency, is a condition that raises your risk ... and other diseases. Some people who have severe AAT deficiency develop emphysema (em-fi-SE-ma)—often ...

  16. IML-1 Logo

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The primary payload for Space Shuttle Mission STS-42, launched January 22, 1992, was the International Microgravity Laboratory-1 (IML-1), a pressurized manned Spacelab module. The goal of IML-1 was to explore in depth the complex effects of weightlessness of living organisms and materials processing. Around-the-clock research was performed on the human nervous system's adaptation to low gravity and effects of microgravity on other life forms such as shrimp eggs, lentil seedlings, fruit fly eggs, and bacteria. Materials processing experiments were also conducted, including crystal growth from a variety of substances such as enzymes, mercury iodide and a virus. More than 200 scientists from 16 countries participated in the investigations. This is the logo or emblem that was designed to represent the IML-1 payload.

  17. Chapter 1: Introduction

    SciTech Connect

    None, None

    2009-01-18

    This report describes analysis undertaken by EERE to better understand the extent to which the technologies and market improvements funded by its fiscal year (FY) 2006 Budget Request1 will make energy more affordable, cleaner, and more reliable.

  18. Cold Sores (HSV-1)

    MedlinePlus

    ... when you were a kid — most likely from direct contact with someone who has it or getting ... person with HSV-1. The virus spreads through direct_contact — through skin contact or contact with oral ...

  19. Cygnus X-1

    NASA Astrophysics Data System (ADS)

    Bolton, C.; Murdin, P.

    2000-11-01

    Cygnus X-1 is one of the strongest x-ray sources. It is the first celestial object for which we had reasonably convincing evidence that it is a BLACK HOLE. Its x-ray properties include an ultra-soft spectrum, compared to massive x-ray binaries containing a neutron star, rapid (˜1 s) flickering, and high/low flux states with different spectral characteristics. In 1971, a RADIO SOURCE appeared at...

  20. Operation HARDTACK 1, 1958

    DTIC Science & Technology

    1982-12-01

    C.I.1656 flccraf& foficatlon and InstrMentation for High-Altitude Technical PhotoqraRhy*** J.G. James Field Comsand, AFSWP 20...11oi1 DOG - Yurochi (Bikini Atoll) IRWI Ske - Bogan - Pokon (Enewotak Atoll) ITEM Bokonfuaaku (Bikini Atoll) JAMES Rjb~eon -Libiron - Ribaion (Enewetak...Kirunu CLARA -Eybblyae -Ruchi (Enewetak Atoll) Lel!RSUGAR -Reere (BikiLfA Atoll) LEROY Biken - Rigi 1. Rigili (Enewetak Atoll) Libiron JAMES - Ribewon

  1. Substituted 1,1,1-Triaryl-2,2,2-Trifluoroethanes and processes for their synthesis

    NASA Technical Reports Server (NTRS)

    Alston, William B. (Inventor); Gratz, Roy F. (Inventor)

    1988-01-01

    Synthetic procedures are described for tetraalkyls, tetraacids and dianhydrides substituted 1,1,1-triaryl-2,2,2-trifluoroethanes which comprises: (1) 1,1-bis(dialkylaryl)-1 aryl-2,2,2-trifluoroethane; (2) 1,1-bis(dicarboxyaryl)-1 aryl-2,2,2-trifluoroethane; or (3) cyclic dianhydride or diamine of 1,1-bis(dialkylaryl)-1 aryl-2,2,2,-trifluoroethanes.

  2. THE E1 PROTEINS

    PubMed Central

    Bergvall, Monika; Melendy, Thomas; Archambault, Jacques

    2013-01-01

    E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structural studies have revealed the assembly pathway of E1 at the origin and how the enzyme unwinds DNA using a spiral escalator mechanism. E1 is tightly regulated in vivo, in particular by post-translational modifications that restrict its accumulation in the nucleus. Here we review how different functional domains of E1 orchestrate viral DNA replication, with an emphasis on their interactions with substrate DNA, host DNA replication factors and modifying enzymes. These studies have made E1 one of the best characterized helicases and provided unique insights on how PVs usurp different host-cell machineries to replicate and amplify their genome in a tightly controlled manner. PMID:24029589

  3. Exposure to ambient PM10 and nitrogen dioxide and ADHD risk: A reply to Min & Min (2017).

    PubMed

    Fluegge, Keith; Fluegge, Kyle

    2017-03-02

    Min and Min (2017) conducted an epidemiological investigation that revealed further support of a link between exposure to air pollution and risk for attention-deficit hyperactivity disorder (ADHD) in childhood. We have previously reported that exposure to the agricultural and combustion pollutant, nitrous oxide (N2O), may be a primary environmental trigger in the onset of neurodevelopmental disorders, like ADHD and autism spectrum disorders. In order to validate our prior work pointing to an association between farm use of nitrogen fertilizers and a severe ADHD phenotype, we have utilized a different statistical approach (i.e., Poisson regression methodology) including two-way fixed effects. The results reported in this correspondence indicate that for a one-log unit increase in the farm use of nitrogen fertilizers, hospitalization risk for ADHD and conduct disorders increases by a factor of 1.16 (p<0.017), which was a statistically significant increase in risk after multiple pollutant comparison correction. Exposure to PM10 and NOx in this analysis was not associated with an increased risk of hospitalization for ADHD and conduct disorder. We are able to validate our prior conclusions and, therefore, suggest that future analyses dedicated to improving the literature on the association between air pollution and risk of ADHD take into account environmental emissions of N2O.

  4. Effect of Antimicrobial Agents on MinD Protein Oscillations in E. coli Bacterial Cells

    NASA Astrophysics Data System (ADS)

    Kelly, Corey; Giuliani, Maximiliano; Dutcher, John

    2012-02-01

    The pole-to-pole oscillation of MinD proteins in E. coli cells determines the location of the division septum, and is integral to healthy cell division. It has been shown previously that the MinD oscillation period is approximately 40 s for healthy cells [1] but is strongly dependant on environmental factors such as temperature, which may place stress on the cell [2,3]. We use a strain of E. coli in which the MinD proteins are tagged with green fluorescent protein (GFP), allowing fluorescence visualization of the MinD oscillation. We use high-resolution total internal reflection fluorescence (TIRF) microscopy and a custom, temperature controlled flow cell to observe the effect of exposure to antimicrobial agents on the MinD oscillation period and, more generally, to analyze the time variation of the spatial distribution of the MinD proteins within the cells. These measurements provide insight into the mechanism of antimicrobial action. [1] Raskin, D.M.; de Boer, P. (1999) Proc. Natl. Acad. Sci. 96: 4971-4976. [2] Touhami, A.; Jericho, M; Rutenberg, A. (2006) J. Bacteriol. 188: 7661-7667. [3] Downing, B.; Rutenberg, A.; Touhami, A.; Jericho, M. (2009) PLoS ONE 4: e7285.

  5. Thermal chemistry of 2-halo-1-propanols on Ni(1 1 1) and Cu(1 1 1) surfaces: A UBI-QEP energetic modeling

    NASA Astrophysics Data System (ADS)

    Mirzanejad, Amir

    2015-12-01

    The effect of β-halogen substitutions on the thermal chemistry of 1-propanol over Ni(1 1 1) and Cu(1 1 1) single-crystal surfaces was investigated using the method of unity bond index-quadratic exponential potential (UBI-QEP). This method was employed to investigate the energetics of the catalytic conversion routes of the ad-molecule mainly at the zero-coverage limit by calculating activation barriers and enthalpy changes for surface reactions. The alcohol molecule can be oxidized partially and totally over the Ni surface, however, the molecule is rather inactive on Cu. The β-halogen substitution makes extensive conversion of the alcohol possible on the Cu surface and changes conversion pathways on the Ni surface. It was found that halogen substitution as well as hydrogen bonding can affect the reactivity and conversion routes of the molecules on Ni and Cu surfaces. On account of energetic criteria, the predicted routes for decompositions and the TPD patterns for the surface species are in accord with the available experimental observations.

  6. PDZK1 and NHERF1 Regulate the Function of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) by Modulating Its Subcellular Trafficking and Stability

    PubMed Central

    Zheng, Jian; Chan, Ting; Cheung, Florence Shin Gee; Zhu, Ling; Murray, Michael; Zhou, Fanfan

    2014-01-01

    The human organic anion transporting polypeptide 1A2 (OATP1A2) is an important membrane protein that mediates the cellular influx of various substances including drugs. Previous studies have shown that PDZ-domain containing proteins, especially PDZK1 and NHERF1, regulate the function of related membrane transporters in other mammalian species. This study investigated the role of PDZK1 and NHERF1 in the regulation of OATP1A2 in an in vitro cell model. Transporter function and protein expression were assessed in OATP1A2-transfected HEK-293 cells that co-expressed PDZK1 or NHERF1. Substrate (estrone-3-sulfate) uptake by OATP1A2 was significantly increased to ∼1.6- (PDZK1) and ∼1.8- (NHERF1) fold of control; this was dependent on the putative PDZ-binding domain within the C-terminus of OATP1A2. The functional increase of OATP1A2 following PDZK1 or NHERF1 over-expression was associated with increased transporter expression at the plasma membrane and in the whole cell, and was reflected by an increase in the apparent maximal velocity of estrone-3-sulfate uptake (Vmax: 138.9±4.1 (PDZK1) and 181.4±16.7 (NHERF1) versus 55.5±3.2 pmol*(µg*4 min)−1 in control; P<0.01). Co-immunoprecipitation analysis indicated that the regulatory actions of PDZK1 and NHERF1 were mediated by direct interaction with OATP1A2 protein. In further experiments PDZK1 and NHERF1 modulated OATP1A2 expression by decreasing its internalization in a clathrin-dependent (but caveolin-independent) manner. Additionally, PDZK1 and NHERF1 enhanced the stability of OATP1A2 protein in HEK-293 cells. The present findings indicated that PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability. PMID:24728453

  7. CHO cell enlargement oscillates with a temperature-compensated period of 24 min

    NASA Technical Reports Server (NTRS)

    Pogue, R.; Morre, D. M.; Morre, D. J.

    2000-01-01

    The rate of increase in cell area of CHO cells when measured at intervals of 1 min using a light microscope equipped with a video measurement system, oscillated with a minimum period of about 24 min. The pattern of oscillations paralleled those of the 24 min period observed with the oxidation of NADH by an external cell surface or plasma membrane NADH oxidase. The increase in cell area was non-linear. Intervals of rapid increase in area alternated with intervals of rapid decrease in area. The length of the 24 min period was temperature-compensated (approximately the same when measured at 14 degrees C, 24 degrees C or 34 degrees C) while the rate of cell enlargement increased with temperature over this same range of temperatures.

  8. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... of the Secretary administers are located in Parts 1-99 of Title 45. • Health regulations are...

  9. 7 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Purpose and scope. 1.1 Section 1.1 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.1 Purpose and scope... process. This subpart also serves as the implementing regulations (referred to in § 1.3,...

  10. 26 CFR 1.50-1 - Restoration of credit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Restoration of credit. 1.50-1 Section 1.50-1... Computing Credit for Investment in Certain Depreciable Property § 1.50-1 Restoration of credit. (a) In general. Section 49(a) (relating to termination of credit) does not apply to property— (1)...

  11. 26 CFR 1.11-1 - Tax on corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Tax on corporations. 1.11-1 Section 1.11-1... Corporations § 1.11-1 Tax on corporations. (a) Every corporation, foreign or domestic, is liable to the tax imposed under section 11 except (1) corporations specifically excepted under such section from such...

  12. An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition

    PubMed Central

    Ondracka, Andrej; Robbins, Jonathan A.; Cross, Frederick R.

    2016-01-01

    B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during and after mitotic exit, APC/C is dependent on Cdh1. Cdh1 is in turn phosphorylated and inactivated by cyclin-CDK at the Start transition of the new cell cycle. We developed a biosensor to assess the cell cycle dynamics of APC/C-Cdh1. Nuclear exit of the G1 transcriptional repressor Whi5 is a known marker of Start; APC/C-Cdh1 is inactivated 12 min after Whi5 nuclear exit with little measurable cell-to-cell timing variability. Multiple phosphorylation sites on Cdh1 act in a redundant manner to repress its activity. Reducing the number of phosphorylation sites on Cdh1 can to some extent be tolerated for cell viability, but it increases variability in timing of APC/C-Cdh1 inactivation. Mutants with minimal subsets of phosphorylation sites required for viability exhibit striking stochasticity in multiple responses including budding, nuclear division, and APC/C-Cdh1 activity itself. Multiple cyclin-CDK complexes, as well as the stoichiometric inhibitor Acm1, contribute to APC/C-Cdh1 inactivation; this redundant control is likely to promote rapid and reliable APC/C-Cdh1 inactivation immediately following the Start transition. PMID:27410035

  13. An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition.

    PubMed

    Ondracka, Andrej; Robbins, Jonathan A; Cross, Frederick R

    2016-01-01

    B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during and after mitotic exit, APC/C is dependent on Cdh1. Cdh1 is in turn phosphorylated and inactivated by cyclin-CDK at the Start transition of the new cell cycle. We developed a biosensor to assess the cell cycle dynamics of APC/C-Cdh1. Nuclear exit of the G1 transcriptional repressor Whi5 is a known marker of Start; APC/C-Cdh1 is inactivated 12 min after Whi5 nuclear exit with little measurable cell-to-cell timing variability. Multiple phosphorylation sites on Cdh1 act in a redundant manner to repress its activity. Reducing the number of phosphorylation sites on Cdh1 can to some extent be tolerated for cell viability, but it increases variability in timing of APC/C-Cdh1 inactivation. Mutants with minimal subsets of phosphorylation sites required for viability exhibit striking stochasticity in multiple responses including budding, nuclear division, and APC/C-Cdh1 activity itself. Multiple cyclin-CDK complexes, as well as the stoichiometric inhibitor Acm1, contribute to APC/C-Cdh1 inactivation; this redundant control is likely to promote rapid and reliable APC/C-Cdh1 inactivation immediately following the Start transition.

  14. [Universal electrogustometer EG-1].

    PubMed

    Pleskacz, Witold A; Wałkanis, Andrzej; Rapiejko, Piotr; Jurkiewicz, Dariusz

    2009-01-01

    Electrogustometry has been used as a clinical tool for diagnosis and assessment of a variety of conditions. Since the lack of versatile electrogustometer for research and diagnosis, the new electrogustometer EG-1 was developed in 2006. It was done in cooperation between Warsaw University of Technology and Military Institute of Medicine in Warsaw. EG-1 allows quantitative estimation of taste perception threshold using both static and impulse electrogustometry with bipolar electrode. It is a fully autonomous, battery powered and portable instrument. Because of small size and weight, it can be easily placed in any environment. Microprocessor controlled measurement system and user-friendly interface (LCD display with simple keyboard) make EG-1 electrogustometer very handy and flexible in operation. Data obtained during measurements is stored in the internal device memory. After taste examinations measurement data can be transferred to a personal computer via inbuilt USB port for further analysis and storage. EG-1 can generate three predefined variously shaped current impulses: sinus-, saw- and rectangle-shaped. There is an optional possibility of creating own shapes of stimulus puls by the user. The electrical parameters of generated pulses are as follow: current amplitude 1-2000 microA regulated with 1 microA step, stimulus frequency 0(DC)-500 Hz regulated with 5 Hz step, controlable fulfillment factor and signal rise time (optional for automatic measurements). The operator can trigger the stimuli via a hand switch on the bipolar electrode (with gold-plated endings), via keyboard or via additional independent hand switch. Three years of experience collected during EG-1 exploitation allowed to design a new version of electrogustometer EG-2 with a touch panel and color graphical display.

  15. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10

    PubMed Central

    Ramírez, Jacqueline; Mirkov, Snezana; House, Larry K.

    2015-01-01

    OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate the inhibitory potential of OTS167 on UGTs. Formation of a single OTS167-glucuronide (OTS167-G) was observed in pooled human liver (HLM) (Km = 3.4 ± 0.2 µM), intestinal microsomes (HIM) (Km = 1.7 ± 0.1 µM), and UGTs. UGT1A1 (64 µl/min/mg) and UGT1A8 (72 µl/min/mg) exhibited the highest intrinsic clearances (CLint) for OTS167, followed by UGT1A3 (51 µl/min/mg) and UGT1A10 (47 µl/min/mg); UGT1A9 was a minor contributor. OTS167 glucuronidation in HLM was highly correlated with thyroxine glucuronidation (r = 0.91, P < 0.0001), SN-38 glucuronidation (r = 0.79, P < 0.0001), and UGT1A1 mRNA (r = 0.72, P < 0.0001). Nilotinib (UGT1A1 inhibitor) and emodin (UGT1A8 and UGT1A10 inhibitor) exhibited the highest inhibitory effects on OTS167-G formation in HLM (68%) and HIM (47%). We hypothesize that OTS167-G is an N-glucuronide according to mass spectrometry. A significant association was found between rs6706232 and reduced OTS167-G formation (P = 0.03). No or weak UGT inhibition (range: 0–21%) was observed using clinically relevant OTS167 concentrations (0.4–2 µM). We conclude that UGT1A1 and UGT1A3 are the main UGTs responsible for hepatic formation of OTS167-G. Intestinal UGT1A1, UGT1A8, and UGT1A10 may contribute to first-pass OTS167 metabolism after oral administration. PMID:25870101

  16. The bacterial cell division regulators MinD and MinC form polymers in the presence of nucleotide.

    PubMed

    Conti, Joseph; Viola, Marissa G; Camberg, Jodi L

    2015-01-16

    The Min system of proteins, consisting of MinC, MinD and MinE, is essential for normal cell division in Escherichia coli. MinC forms a polar gradient to restrict placement of the division septum to midcell. MinC localization occurs through a direct interaction with MinD, a membrane-associating Par-like ATPase. MinE stimulates ATP hydrolysis by MinD, thereby releasing MinD from the membrane. Here, we show that MinD forms polymers with MinC and ATP without the addition of phospholipids. The topological regulator MinE induces disassembly of MinCD polymers. Two MinD mutant proteins, MinD(K11A) and MinD(ΔMTS15), are unable to form polymers with MinC.

  17. PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability.

    PubMed

    Zheng, Jian; Chan, Ting; Cheung, Florence Shin Gee; Zhu, Ling; Murray, Michael; Zhou, Fanfan

    2014-01-01

    The human organic anion transporting polypeptide 1A2 (OATP1A2) is an important membrane protein that mediates the cellular influx of various substances including drugs. Previous studies have shown that PDZ-domain containing proteins, especially PDZK1 and NHERF1, regulate the function of related membrane transporters in other mammalian species. This study investigated the role of PDZK1 and NHERF1 in the regulation of OATP1A2 in an in vitro cell model. Transporter function and protein expression were assessed in OATP1A2-transfected HEK-293 cells that co-expressed PDZK1 or NHERF1. Substrate (estrone-3-sulfate) uptake by OATP1A2 was significantly increased to ∼1.6- (PDZK1) and ∼1.8- (NHERF1) fold of control; this was dependent on the putative PDZ-binding domain within the C-terminus of OATP1A2. The functional increase of OATP1A2 following PDZK1 or NHERF1 over-expression was associated with increased transporter expression at the plasma membrane and in the whole cell, and was reflected by an increase in the apparent maximal velocity of estrone-3-sulfate uptake (V(max): 138.9±4.1 (PDZK1) and 181.4±16.7 (NHERF1) versus 55.5±3.2 pmol*(µg*4 min)⁻¹ in control; P<0.01). Co-immunoprecipitation analysis indicated that the regulatory actions of PDZK1 and NHERF1 were mediated by direct interaction with OATP1A2 protein. In further experiments PDZK1 and NHERF1 modulated OATP1A2 expression by decreasing its internalization in a clathrin-dependent (but caveolin-independent) manner. Additionally, PDZK1 and NHERF1 enhanced the stability of OATP1A2 protein in HEK-293 cells. The present findings indicated that PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.

  18. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

    PubMed Central

    de Jong, Petrus R.; Takahashi, Naoki; Harris, Alexandra R.; Lee, Jihyung; Bertin, Samuel; Jeffries, James; Jung, Michael; Duong, Jen; Triano, Amy I.; Lee, Jongdae; Niv, Yaron; Herdman, David S.; Taniguchi, Koji; Kim, Chang-Whan; Dong, Hui; Eckmann, Lars; Stanford, Stephanie M.; Bottini, Nunzio; Corr, Maripat; Raz, Eyal

    2014-01-01

    The intestinal epithelium has a high rate of turnover, and dysregulation of pathways that regulate regeneration can lead to tumor development; however, the negative regulators of oncogenic events in the intestinal epithelium are not fully understood. Here we identified a feedback loop between the epidermal growth factor receptor (EGFR), a known mediator of proliferation, and the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), in intestinal epithelial cells (IECs). We found that TRPV1 was expressed by IECs and was intrinsically activated upon EGFR stimulation. Subsequently, TRPV1 activation inhibited EGFR-induced epithelial cell proliferation via activation of Ca2+/calpain and resulting activation of protein tyrosine phosphatase 1B (PTP1B). In a murine model of multiple intestinal neoplasia (ApcMin/+ mice), TRPV1 deficiency increased adenoma formation, and treatment of these animals with an EGFR kinase inhibitor reversed protumorigenic phenotypes, supporting a functional association between TRPV1 and EGFR signaling in IECs. Administration of a TRPV1 agonist suppressed intestinal tumorigenesis in ApcMin/+ mice, similar to — as well as in conjunction with — a cyclooxygenase-2 (COX-2) inhibitor, which suggests that targeting both TRPV1 and COX-2 has potential as a therapeutic approach for tumor prevention. Our findings implicate TRPV1 as a regulator of growth factor signaling in the intestinal epithelium through activation of PTP1B and subsequent suppression of intestinal tumorigenesis. PMID:25083990

  19. Uptake and distribution of the abused inhalant 1,1-difluoroethane in the rat.

    PubMed

    Avella, Joseph; Kunaparaju, Naveen; Kumar, Sunil; Lehrer, Michael; Zito, S William; Barletta, Michael

    2010-09-01

    1,1-Difluoroethane (DFE) is a halogenated hydrocarbon used as a propellant in products designed for dusting electronic equipment and air brush painting. When abused, inhaled DFE produces intoxication and loss of muscular coordination. To investigate DFE toxicokinetics, groups (n = 3) of Sprague-Dawley rats were exposed to 30 s of 20 L/min DFE. The experimental model was designed to mimic exposure during abuse, a protocol which has not been conducted. Tissue collection (blood, brain, heart, liver, and kidney) occurred at 0, 10, 20, 30, 45, 60, 120, 240, 480, and 900 s. Average peak DFE levels were blood 352, brain 519, heart 338, liver 187, and kidney 364 mg/L or mg/kg. The total percent uptake of the administered dose was 4.0%. Uptake into individual compartments was 2.72, 0.38, 0.15, 0.41, and 0.32% for blood, brain, heart, liver, and kidney, respectively. All animals showed signs of intoxication within 20 s manifested as lethargy, prostration and loss of righting reflex. Marked intoxication continued for about 4 min when DFE averaged 21 mg/L in blood and 17 mg/kg in brain. Between 4 and 8 min, animals continued to show signs of sedation as evidenced by reduced aggression and excitement during handling. No discernable intoxication was evident after 8 min and blood and brain levels had fallen to 10 and 6 mg/L or kg, respectively. Plots of concentration (log) versus time were consistent with a two compartment model. Initial distribution was rapid with average half life (t((1/2))) during the alpha phase of 9 s for blood, 18 s for brain and 27 s in cardiac tissue. During beta slope elimination average t((1/2)) was 86 s in blood, 110 s in brain and 168 s in heart. Late elimination half lives were longer with blood gamma = 240 s, brain gamma = 340 s, and heart gamma = 231 s. Following acute exposure the Vd = 0.06 L, beta = 0.48 min(-1), AUC = 409.8 mg.min L(-1), and CL from blood was 0.03 L min(-1). The calculated toxicokinetic data may underestimate these parameters if

  20. TRUPACT-1 implementation plan

    SciTech Connect

    Hurley, J.D.; Tappen, J.J. . Joint Integration Office); Christensen, D.S. )

    1985-09-01

    TRUPACT-1, the TRansUranic PACkage Transporter is a packaging designed to transport defense contact handled transuranic (CH-TRU) waste from generating and interim TRU waste storage facilities to the Waste Isolation Pilot Plant (WIPP). Prior to fabrication and procurement of a full fleet, an initial design (TRUPACT-1) will be introduced to the defense TRU waste complex through use in an operational prototype fleet which will consist of Units 1, 2, and 3. In an effort to provide a relatively smooth introduction of the TRUPACT-1, the TRUPACT Technical Team (TTT) has developed the following implementation plan. The plan provides detailed information on user handling opportunities, schedules, equipment, responsibilities, reporting and data collection activities to be performed. The intent of this document is to provide users of the TRUPACT-1 with a guidance document, complete with references, that will allow the smooth introduction of this new transportation system by providing the information necessary for collecting operational, performance and cost data. These data will be used in modeling and full fleet design and procurement activities. In addition, these data will help fine tune procedures in the inspection and maintenance document and the operational document. Additional objectives of this plan are to aid in the establishment of site operational, inspection and maintenance procedures as well as training of site operators and briefing state and local officials.

  1. HERG1 channelopathies

    PubMed Central

    2009-01-01

    Human ether a go-go-related gene type 1 (hERG1) K+ channels conduct the rapid delayed rectifier K+ current and mediate action potential repolarization in the heart. Mutations in KCNH2 (the gene that encodes hERG1) causes LQT2, one of the most common forms of long QT syndrome, a disorder of cardiac repolarization that predisposes affected subjects to ventricular arrhythmia and increases the risk of sudden cardiac death. Hundreds of LQT2-associated mutations have been described, and most cause a loss of function by disrupting subunit folding, assembly, or trafficking of the channel to the cell surface. Loss-of-function mutations in hERG1 channels have also recently been implicated in epilepsy. A single gain-of-function mutation has been described that causes short QT syndrome and cardiac arrhythmia. In addition, up-regulation of hERG1 channel expression has been demonstrated in specific tumors and has been associated with skeletal muscle atrophy in mice. PMID:20544339

  2. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES...

  3. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES...

  4. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES...

  5. 49 CFR 172.522 - EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3... INFORMATION, TRAINING REQUIREMENTS, AND SECURITY PLANS Placarding § 172.522 EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES 1.3 placards. (a) Except for size and color, the EXPLOSIVES 1.1, EXPLOSIVES 1.2 and EXPLOSIVES...

  6. HIV-1 replication.

    PubMed

    Freed, E O

    2001-11-01

    In general terms, the replication cycle of lentiviruses, including HIV-1, closely resembles that of other retroviruses. There are, however, a number of unique aspects of HIV replication; for example, the HIVs and SIVs target receptors and coreceptors distinct from those used by other retroviruses. Lentiviruses encode a number of regulatory and accessory proteins not encoded by the genomes of the prototypical "simple" retroviruses. Of particular interest from the gene therapy perspective, lentiviruses possess the ability to productively infect some types of non-dividing cells. This chapter, while reiterating certain points discussed in Chapter 1, will attempt to focus on issues unique to HIV-1 replication. The HIV-1 genome encodes the major structural and non-structural proteins common to all replication-competent retroviruses (Fig. 1, and Chapter 1). From the 5'- to 3'-ends of the genome are found the gag (for group-specific antigen), pol (for polymerase), and env (for envelope glycoprotein) genes. The gag gene encodes a polyprotein precursor whose name, Pr55Gag, is based on its molecular weight. Pr55Gag is cleaved by the viral protease (PR) to the mature Gag proteins matrix (also known as MA or p17), capsid (CA or p24), nucleocapsid (NC or p7), and p6. Two spacer peptides, p2 and p1, are also generated upon Pr55Gag processing. The pol-encoded enzymes are initially synthesized as part of a large polyprotein precursor, Pr160GagPol, whose synthesis results from a rare frameshifting event during Pr55Gag translation. The individual pol-encoded enzymes, PR, reverse transcriptase (RT), and integrase (IN), are cleaved from Pr160GagPol by the viral PR. The envelope (Env) glycoproteins are also synthesized as a polyprotein precursor (Fig. 1). Unlike the Gag and Pol precursors, which are cleaved by the viral PR, the Env precursor, known as gp160, is processed by a cellular protease during Env trafficking to the cell surface, gp160 processing results in the generation of the

  7. Spin-1 quantum walks

    NASA Astrophysics Data System (ADS)

    Morita, Daichi; Kubo, Toshihiro; Tokura, Yasuhiro; Yamashita, Makoto

    2016-06-01

    We study the quantum walks of two interacting spin-1 bosons. We derive an exact solution for the time-dependent wave function, which describes the two-particle dynamics governed by the one-dimensional spin-1 Bose-Hubbard model. We show that propagation dynamics in real space and mixing dynamics in spin space are correlated via the spin-dependent interaction in this system. The spin-mixing dynamics has two characteristic frequencies in the limit of large spin-dependent interactions. One of the characteristic frequencies is determined by the energy difference between two bound states, and the other frequency relates to the cotunneling process of a pair of spin-1 bosons. Furthermore, we numerically analyze the growth of the spin correlations in quantum walks. We find that long-range spin correlations emerge showing a clear dependence on the sign of the spin-dependent interaction and the initial state.

  8. 26 CFR 1.642(a)(1)-1 - Partially tax-exempt interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Partially tax-exempt interest. 1.642(a)(1)-1 Section 1.642(a)(1)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.642(a)(1)-1 Partially...

  9. 78 FR 40099 - 1-Hydroxyethylidene-1, 1-Diphosphonic Acid From India: Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... International Trade Administration 1-Hydroxyethylidene-1, 1-Diphosphonic Acid From India: Final Results of... of the antidumping duty order on 1-hydroxyethylidene-1, 1-diphosphonic acid (HEDP) from India.\\1\\ The...-Hydroxyethylidene-1, 1-Diphosphonic Acid from India: Preliminary Results of Antidumping Duty Administrative...

  10. 76 FR 78237 - 1-Hydroxyethylidene-1, 1-Diphosphonic Acid From India: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... International Trade Administration 1-Hydroxyethylidene-1, 1-Diphosphonic Acid From India: Preliminary Results of... administrative review of the antidumping duty order on 1-hydroxyethylidene-1, 1-diphosphonic acid (HEDP) from...- hydroxyethylidene-1, 1-diphosphonic acid \\1\\, also referred to as hydroxethlylidenediphosphonic...

  11. Anguillid Herpesvirus 1 Transcriptome

    PubMed Central

    van Beurden, Steven J.; Gatherer, Derek; Kerr, Karen; Galbraith, Julie; Herzyk, Pawel; Peeters, Ben P. H.; Rottier, Peter J. M.; Engelsma, Marc Y.

    2012-01-01

    We used deep sequencing of poly(A) RNA to characterize the transcriptome of an economically important eel virus, anguillid herpesvirus 1 (AngHV1), at a stage during the lytic life cycle when infectious virus was being produced. In contrast to the transcription of mammalian herpesviruses, the overall level of antisense transcription from the 248,526-bp genome was low, amounting to only 1.5% of transcription in predicted protein-coding regions, and no abundant, nonoverlapping, noncoding RNAs were identified. RNA splicing was found to be more common than had been anticipated previously. Counting the 10,634-bp terminal direct repeat once, 100 splice junctions were identified, of which 58 were considered likely to be involved in the expression of functional proteins because they represent splicing between protein-coding exons or between 5′ untranslated regions and protein-coding exons. Each of the 30 most highly represented of these 58 splice junctions was confirmed by RT-PCR. We also used deep sequencing to identify numerous putative 5′ and 3′ ends of AngHV1 transcripts, confirming some and adding others by rapid amplification of cDNA ends (RACE). The findings prompted a revision of the AngHV1 genome map to include a total of 129 protein-coding genes, 5 of which are duplicated in the terminal direct repeat. Not counting duplicates, 11 genes contain integral, spliced protein-coding exons, and 9 contain 5′ untranslated exons or, because of alternative splicing, 5′ untranslated and 5′ translated exons. The results of this study sharpen our understanding of AngHV1 genomics and provide the first detailed view of a fish herpesvirus transcriptome. PMID:22787220

  12. Preparation of 1,1'-dinitro-3,3'-azo-1,2,4-triazole. [1,1'-dinitro-3,3'-azo-1,2,4-triazole

    DOEpatents

    Lee, K.Y.

    1985-03-05

    A new high density composition of matter, 1,1'-dinitro-3,3'-azo-1,2,4-triazole, has been synthesized using inexpensive, commonly available compounds. This compound has been found to be an explosive, and its use as a propellant is anticipated. 1 fig., 1 tab.

  13. Apollo 1 Prime Crew

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Portrait of the Apollo 1 prime crew for first manned Apollo space flight. From left to right are: Edward H. White II, Virgil I. 'Gus' Grissom, and Roger B. Chaffee. On January 27, 1967 at 5:31 p.m. CST (6:31 local time) during a routine simulated launch test onboard the Apollo Saturn V Moon rocket, an electrical short circuit inside the Apollo Command Module ignited the pure oxygen environment and within a matter of seconds all three Apollo 1 crewmembers perished.

  14. IO SUBSYSTEM 1 BETA

    SciTech Connect

    Sjaardema, Greg

    2002-08-21

    "IO Subsystem Ver. 1.0 Beta" uses standard object-oriented principles to minimize dependencies between the underlying input or output database format and the client code (i.e., Sierra) using the io subsystem. The interface and priciples are simolar to the Facade pattern described in the "Design Patterns" book by Gamma, et.al. The software uses data authentication algorithms to ensure data input/output is consistent with model being defined. "IO Subsystem Ver. 1.0 Beta" is a database independent input/output library for finite element analysis, preprocessing, post processing, and translation programs.

  15. Isolation and characterisation of poliovirus mutants resistant to heating at 50 degrees Celsius for 30 min.

    PubMed

    Shiomi, Hiroshi; Urasawa, Tomoko; Urasawa, Shozo; Kobayashi, Nobumichi; Abe, Shibobu; Taniguchi, Koki

    2004-11-01

    Poliovirus is heat-labile; on heating at 50 degrees Celsius for 30 min its infectivity decreases drastically and its antigenicity reverts from N to H. However, mutants resistant to heating at 50 degrees Celsius for 30 min from the Sabin 1 and 2 viruses were isolated by repeating the process of incubation of the virus stock at 50 degrees Celsius for 30 min and multiplication of the remaining virus in a cell culture. The isolated mutants were stable genetically, and maintained the rct and d markers of the parent virus. On electron microscopical examination, the mutants were observed to retain the intact morphology after being heated at 50 degrees Celsius for 30 min, while the parent virus was converted to empty particles devoid of RNA under the same conditions. On determination of the nucleotide sequence of the P1 region, a single nucleotide sequence substitution was detected at nucleotide no. 2741, resulting in an amino acid change from valine to alanine at the 87th position of VP1. This amino acid might be associated with the heat-resistance of the mutants. Furthermore, it was found that the thermostable mutants obtained in this study, which are resistant to "high" temperature (50 degrees Celsius) for a short time (30 min), were not stable against heating at the ambient temperature (37 degrees Celsius) for a long time (5 or 7 days). This suggests that the inactivation at high temperature for a short time and that at ambient temperature for a long time involve different mechanisms.

  16. Infrared reflection absorption spectroscopic study of the adsorption structures of dimethyl ether and methyl ethyl ether on Cu(1 1 1) and Ag(1 1 1)

    NASA Astrophysics Data System (ADS)

    Kasahara, Takahiro; Itoh, Koichi

    2007-02-01

    Infrared reflection absorption (IRA) spectra measured for dimethyl ether (DME) adsorbed at 80 K on Cu(1 1 1) and Ag(1 1 1) give IR bands belonging only to the A 1 and B 2 species, indicating that the adsorbate takes on an orientation in which the C2 axis bisecting the COC bond angle tilts away from the surface normal within the plane perpendicular to the substrates. The DFT method was applied to simulate the IRA spectra, indicating that the tilt angles of DME on Cu(1 1 1) and Ag(1 1 1) are about 50° and 55°, respectively, at submonolayer coverages. The results are in contrast to the case of DME on Cu(1 1 0) and Ag(1 1 0), where the C2 axis is perpendicular to the substrates [T. Kiyohara et al., J. Phys. Chem. A 106 (2002) 3469]. Methyl ethyl ether (MEE) adsorbed at 80 K on Cu(1 1 1) gives IRA bands mainly ascribable to the gauche ( G) form, whereas the IRA spectra measured for MEE on Ag(1 1 1) are characterized by the trans ( T) form. The rotational isomers are identical with those on Cu(1 1 0) and Ag(1 1 0); i.e., MEE on Cu(1 1 0) takes the G form and the adsorbate on Ag(1 1 0) the T form [T. Kiyohara et al., J. Phys. Chem. B 107 (2003) 5008]. The simulation of the IRA spectra indicated that (i) the G form adsorbate on Cu(1 1 1) takes an orientation, in which the axis bisecting the COC bond angle tilts away from the surface normal by ca. 30° within the plane perpendicular to the surface to make the CH 3-CH 2 bond almost parallel to the surface, and (ii) the T form adsorbate on Ag(1 1 1) takes an orientation, in which the bisecting axis tilts away by ca. 60° from the surface normal within the perpendicular plane. Comparison of these adsorption structures of MEE on the (1 1 1) substrates with those of MEE on Cu(1 1 0) and Ag(1 1 0) indicates that the structures are mainly determined by a coordination interaction of the oxygen atom to the surface metals and an attractive van der Waals interaction between the ethyl group of MEE and the substrate surfaces. The

  17. Adsorption of water on TiN (1 0 0), (1 1 0) and (1 1 1) surfaces: A first-principles study

    NASA Astrophysics Data System (ADS)

    Sanyal, Suchismita; Waghmare, Umesh V.; Ruud, James A.

    2011-05-01

    We use first-principles density functional theory-based calculations in the analysis of the interaction of H 2O with (1 0 0), (1 1 0) and (1 1 1) surfaces of TiN, and develop understanding in terms of surface energies, polarity of the surface and chemistry of the cation, through comparison with H 2O adsorption on ZrN. While water molecule physisorbs preferentially at Ti site of (1 0 0) and (1 1 1) surfaces, it adsorbs dissociatively on (1 1 0) surface of TiN with binding stronger than almost 1.32 eV/molecule. Our analysis reveals the following general trends: (a) surfaces with higher energies typically lead to stronger adsorption, (b) dissociative adsorption of H 2O necessarily occurs on a charge neutral high energy surface and (c) lower symmetry of the (1 1 0) plane results in many configurations of comparable stability, as opposed to the higher symmetry (1 0 0) and (1 1 1) surfaces, which also consistently explain the results of H 2O adsorption on MgO available in literature. Finally, weaker adsorption of H 2O on TiN than on ZrN can be rationalized in terms of greater chemical stability of Ti arising from its ability to be in mixed valence.

  18. The S1( 1A1)- S0( 1A1) Electronic Transition of Jet-Cooled o-Difluorobenzene

    NASA Astrophysics Data System (ADS)

    Swinn, Anna K.; Kable, Scott H.

    1998-09-01

    A detailed study of theS1(1A1)-S0(1A1) transition of jet-cooledo-difluorobenzene has been completed using the two techniques of laser-induced fluorescence excitation and dispersed, single vibronic level fluorescence spectroscopy. Analysis of over 60 dispersed fluorescence spectra resulted in both the assignment of 22 excited state vibrational frequencies and the confirmation of 23 ground state frequencies. The spectrum is dominated by Franck-Condon activity in totally symmetric vibrations with long progressions in the ring-breathing mode, ν9. By analogy with benzene and thepara- andmeta-substituted isomers, two vibronic coupling mechanisms are postulated to be responsible for the wealth of weaker symmetry-forbidden structure that has been observed. Single quantum changes inb2vibrations are postulated to appear due to first order vibronic coupling to a higher lyingB2electronic state. Combinations ofb1anda2modes are postulated to appear from second order vibronic coupling to anA1electronic state. This second order coupling causes a pronounced Duschinsky mixing among excited stateb1anda2modes with respect to their ground state counterparts. Franck-Condon factors are calculated for thea1progression-forming modes, anharmonic contributions are evaluated, one strong Fermi resonance is identified and analyzed, and the Duschinsky rotation matrix elements are evaluated for the most strongly affected modes, ν17and ν18. Several transitions in theoDFB-oDFB van der Waals dimer andoDFB-Ar complex are also assigned in the spectrum.

  19. U1A Complex

    SciTech Connect

    2014-10-28

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  20. Where is Phobos 1?

    NASA Astrophysics Data System (ADS)

    1988-12-01

    The Soviet spacecraft Phobos 1, launched in July this year and now en route to Mars and its major moon, was lost due to an incorrect ground control command. Many attempts were made to reestablish radio-contact, but unfortunately in vain.

  1. OPERATION ALPHABET, 1.

    ERIC Educational Resources Information Center

    COATES, ROBERT H., ED.

    OPERATION ALPHABET 1 IS THE FIRST OF A SERIES OF WORKBOOKS PLANNED TO HELP ADULTS LEARN TO READ AND WRITE. EACH OF THE 100 LESSONS DEVELOPS ONE IDEA OF INTEREST TO ADULTS, EMPHASIZING KEY WORDS AND PRACTICE WRITING EXERCISES. WORDS USED IN THE LESSONS ARE DEFINED AT THE END OF THE BOOK. THIS DOCUMENT IS AVAILABLE FROM NOBLE AND NOBLE, PUBLISHERS,…

  2. The Remarkable Number "1"

    ERIC Educational Resources Information Center

    Allen, G. Donald

    2014-01-01

    In human history, the origin of the numbers came from definite practical needs. Indeed, there is strong evidence that numbers were created before writing. The number "1", dating back at least 20,000 years, was found as a counting symbol on a bone. The famous statement by the German mathematician Leopold Kronecker (1823-1891), "God…

  3. U1A Complex

    ScienceCinema

    None

    2016-07-12

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  4. Verizon's New # Is 1

    ERIC Educational Resources Information Center

    Freifeld, Lorri

    2012-01-01

    One may be the loneliest number, but Verizon isn't complaining. After appearing five times in the Top 10 over the last six years, the telecommunications company captured the No. 1 spot on the Training Top 125 for the first time in 2012. Despite a relatively flat training budget and a work stoppage that resulted from the expiration of union…

  5. Rescue Manual. Module 1.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This learner manual for rescuers covers the current techniques or practices required in the rescue service. The first of 10 modules contains 9 chapters: (1) introduction; (2) occupational stresses in rescue operations; (3) size-up; (4) critique; (5) reports and recordkeeping; (6) tools and equipment for rescue operations; (7) planning for…

  6. 1 Main Street, Mars

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Located outside StenniSphere, the visitor center at John C. Stennis Space Center, 1 Main Street Mars is a model of how a habitat on Mars might look. Complete with thermometers, scales and clocks set to Martian equivalents, this exhibit shows how very different life on Mars can be.

  7. 1,4-Dibromobenzene

    Integrated Risk Information System (IRIS)

    1,4 - Dibromobenzene ; CASRN 106 - 37 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  8. Avermectin B1

    Integrated Risk Information System (IRIS)

    Avermectin B1 ; CASRN 65195 - 55 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic E

  9. 1,2-Diphenylhydrazine

    Integrated Risk Information System (IRIS)

    1,2 - Diphenylhydrazine ; CASRN 122 - 66 - 7 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcin

  10. 1,4-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,4 - Dichlorobenzene ; CASRN 106 - 46 - 7 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinog

  11. 1,2-Dibromoethane

    Integrated Risk Information System (IRIS)

    EPA 635 / R - 04 / 067 www.epa.gov / iris TOXICOLOGICAL REVIEW OF 1,2 - DIBROMOETHANE ( CAS No . 106 - 93 - 4 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) June 2004 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has been revie

  12. 1,3-Dichloropropene

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 00 / 001 TOXICOLOGICAL REVIEW OF 1,3 - DICHLOROPROPENE ( CAS No . 542 - 75 - 6 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) May 2000 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has been reviewed in accordanc

  13. PECAM-1 and Angiogenesis

    DTIC Science & Technology

    2009-12-01

    studies have shown that systemic delivery of an anti–PECAM-1 ribozyme suppresses the progression of already established tumor metastases (11). We...plasmid-based ribozyme targeting in adult mice. Proc Natl Acad Sci USA 99:3878–3883. 12. Vantyghem SA, Postenka CO, Chambers AF (2003) Estrous cycle

  14. Spacelab D-1 mission

    NASA Technical Reports Server (NTRS)

    Dunbar, Bonnie J.

    1990-01-01

    The Spacelab D-1 (Deutchland Eins) Mission is discussed from the points of view of safety, materials handling, and toxic materials; the laboratory and equipment used; and some of the different philosophies utilized on this flight. How to enhance scientific return at the same time as being safe was examined.

  15. HTLV-1-targeted immunotherapy.

    PubMed

    Suehiro, Youko

    Adult T-cell leukemia/lymphoma (ATL) is a HTLV-1 induced T-cell malignancy with an extremely poor prognosis. There is a long latency period between HTLV-1 infection and the onset of ATL, which indicates the existence of multistep mechanisms of leukemogenesis in the infected cells. Tax, which is encoded by the HTLV-1 pX region, plays a crucial role in HTLV-1 leukemogenesis and is a major target of CTL. We developed an anti-ATL therapeutic vaccine consisting of autologous dendritic cells that is pulsed with Tax peptides (Tax-DC). The vaccination protocol was completed with three injections at a 2-week interval, within one month. Good quality of life and long-term treatment-free survival were observed for more than 3 years in two of the three patients enrolled in the pilot study. Furthermore, the proviral load remained mostly around the carrier level, with minor fluctuation, after vaccination. Tax-specific proliferative CTL responses were observed in all cases and sporadically augmented responses were also subsequently detected. The Tax-DC vaccine might be a well-tolerated and long-lasting maintenance therapy that is acceptable even for elderly patients. Based on the encouraging results, we are now conducting a clinical trial of Tax-DC vaccine combined with anti-CCR4 antibody to enhance the efficacy of the vaccine as next-generation immunotherapy.

  16. Spacelab Life Sciences-1

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-40, carrying Spacelab Life Sciences-1, was the first dedicated to study the human body in microgravity. Experiments regarding adaptation to space and readaptation to the world of gravity are discussed in this video. Spacelab is another precursor to long-term science aboard the space station.

  17. 1,4-Dithiane

    Integrated Risk Information System (IRIS)

    1,4 - Dithiane ; CASRN 505 - 29 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic Ef

  18. 1,3-Butadiene

    Integrated Risk Information System (IRIS)

    1,3 - Butadiene ; CASRN 106 - 99 - 0 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic E

  19. 1,2-Dichloropropane

    Integrated Risk Information System (IRIS)

    1,2 - Dichloropropane ; CASRN 78 - 87 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  20. Document Design: Part 1.

    ERIC Educational Resources Information Center

    Andrews, Deborah C., Ed.; Dyrud, Marilyn, Ed.

    1996-01-01

    Presents four articles that provide suggestions for teaching document design: (1) "Teaching the Rhetoric of Document Design" (Michael J. Hassett); (2) "Teaching by Example: Suggestions for Assignment Design" (Marilyn A. Dyrud); (3) "Teaching the Page as a Visual Unit" (Bill Hart-Davidson); and (4) "Designing a…

  1. Pharmacogenetics of OPRM1

    PubMed Central

    Crist, Richard C.; Berrettini, Wade H.

    2013-01-01

    Pharmacogenetic research has the potential to explain the variation in treatment efficacy within patient populations. Understanding the interaction between genetic variation and medications may provide a method for matching patients to the most effective therapeutic options and improving overall patient outcomes. The OPRM1 gene has been a target of interest in a large number of pharmacogenetic studies due to its genetic and structural variation, as well as the role of opioid receptors in a variety of disorders. The mu-opioid receptor (MOR), encoded by OPRM1, naturally regulates the analgesic response to pain and also controls the rewarding effects of many drugs of abuse, including opioids, nicotine, and alcohol. Genetic variants in OPRM1, particularly the nonsynonymous polymorphism A118G, have been repeatedly associated with the efficacy of treatments for pain and various types of dependence. This review focuses on the current understanding of the pharmacogenetic impact of OPMR1, primarily in regards to the treatment of pain and addiction. PMID:24201053

  2. Gentilly 1: decontamination program

    SciTech Connect

    Le, H.; Denault, P.

    1985-11-01

    The Gentilly 1 station, a 250-MW(e) light-water-cooled and heavy-water-moderated nuclear reactor, is being decommissioned to a static state (variant of stage 1) condition by Atomic Energy of Canada Limited (AECL). The scope of the decontamination program at the Gentilly 1 site includes the fuel pool and associated systems, the decontamination center, the laundry, the feedwater pumps and piping systems, the service building ventilation and drainage systems, and miscellaneous floor and wall areas. After an extensive literature review for acceptable decontamination methods, it was decided that the decontamination equipment used at Gentilly 1 during the program would include a hydrolaser, a scarifier, chipping hammers, a steam cleaner, an ultrasonic bath, and cutting tools. In addition, various foams, acids, detergents, surfactants, and abrasives are used alone and in tandem with the above equipment. This paper highlights the result of these decontaminations, their effectiveness, and the recommendation for future application. The methodology in performing these operations are also presented.

  3. 1,2-Dichloroethane

    Integrated Risk Information System (IRIS)

    1,2 - Dichloroethane ; CASRN 107 - 06 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  4. 50 CFR 1.1 - Meaning of terms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Meaning of terms. 1.1 Section 1.1 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.1 Meaning of terms. As used in this chapter, unless separately defined, terms shall have...

  5. 2009 H1N1 Flu Vaccine Facts

    MedlinePlus

    ... turn Javascript on. Feature: Flu 2009 H1N1 Flu Vaccine Facts Past Issues / Fall 2009 Table of Contents ... H1N1 flu vaccine. 1 The 2009 H1N1 flu vaccine is safe and well tested. Clinical trials conducted ...

  6. 26 CFR 1.23-1 - Residential energy credit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... which he received a loan of $5,000 from the Federal Solar-Energy and Energy Conservation Bank. Assume... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Residential energy credit. 1.23-1 Section 1.23-1... Rates During A Taxable Year § 1.23-1 Residential energy credit. (a) General rule. Section 23 or...

  7. 26 CFR 1.23-1 - Residential energy credit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... which he received a loan of $5,000 from the Federal Solar-Energy and Energy Conservation Bank. Assume... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Residential energy credit. 1.23-1 Section 1.23-1... Rates During A Taxable Year § 1.23-1 Residential energy credit. (a) General rule. Section 23 or...

  8. 26 CFR 1.23-1 - Residential energy credit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... which he received a loan of $5,000 from the Federal Solar-Energy and Energy Conservation Bank. Assume... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Residential energy credit. 1.23-1 Section 1.23-1... Rates During A Taxable Year § 1.23-1 Residential energy credit. (a) General rule. Section 23 or...

  9. 26 CFR 1.23-1 - Residential energy credit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... which he received a loan of $5,000 from the Federal Solar-Energy and Energy Conservation Bank. Assume... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Residential energy credit. 1.23-1 Section 1.23-1... Rates During A Taxable Year § 1.23-1 Residential energy credit. (a) General rule. Section 23 or...

  10. 26 CFR 1.23-1 - Residential energy credit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... which he received a loan of $5,000 from the Federal Solar-Energy and Energy Conservation Bank. Assume... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Residential energy credit. 1.23-1 Section 1.23-1... Rates During A Taxable Year § 1.23-1 Residential energy credit. (a) General rule. Section 23 or...

  11. 26 CFR 1.402A-1 - Designated Roth Accounts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Designated Roth Accounts. 1.402A-1 Section 1... (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.402A-1 Designated Roth Accounts. Q-1. What is a designated Roth account? A-1. A designated Roth account is a separate account under...

  12. 7 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Purpose and scope. 1.1 Section 1.1 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.1 Purpose and scope... Communications has the primary responsibility for implementation of the FOIA in the Department of...

  13. 7 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Purpose and scope. 1.1 Section 1.1 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.1 Purpose and scope... Communications has the primary responsibility for implementation of the FOIA in the Department of...

  14. 26 CFR 1.85-1 - Unemployment compensation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Unemployment compensation. 1.85-1 Section 1.85-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.85-1 Unemployment compensation... unemployment compensation (as defined in paragraph (b)(1) of this section) paid in taxable years...

  15. 26 CFR 1.85-1 - Unemployment compensation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Unemployment compensation. 1.85-1 Section 1.85-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.85-1 Unemployment compensation... unemployment compensation (as defined in paragraph (b)(1) of this section) paid in taxable years...

  16. 26 CFR 1.85-1 - Unemployment compensation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Unemployment compensation. 1.85-1 Section 1.85-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.85-1 Unemployment compensation... unemployment compensation (as defined in paragraph (b)(1) of this section) paid in taxable years...

  17. 26 CFR 1.85-1 - Unemployment compensation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Unemployment compensation. 1.85-1 Section 1.85-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.85-1 Unemployment compensation... unemployment compensation (as defined in paragraph (b)(1) of this section) paid in taxable years...

  18. 26 CFR 1.85-1 - Unemployment compensation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Unemployment compensation. 1.85-1 Section 1.85-1...) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.85-1 Unemployment compensation... unemployment compensation (as defined in paragraph (b)(1) of this section) paid in taxable years...

  19. 47 CFR 1.1943-1.1949 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false 1.1943-1.1949 Section 1.1943-1.1949 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection... §§ 1.1943-1.1949 Cooperation With the Internal Revenue Service...

  20. 26 CFR 1.74-1 - Prizes and awards.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Prizes and awards. 1.74-1 Section 1.74-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Items Specifically Included in Gross Income § 1.74-1 Prizes and awards. (a) Inclusion in gross income. (1) Section...

  1. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the...

  2. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of...

  3. 50 CFR 1.1 - Meaning of terms.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 1 2011-10-01 2011-10-01 false Meaning of terms. 1.1 Section 1.1 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.1 Meaning of terms. As used in this chapter, unless separately defined, terms shall have...

  4. 47 CFR 1.1 - Proceedings before the Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Proceedings before the Commission. 1.1 Section 1.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE General Rules of Practice and Procedure General § 1.1 Proceedings before the Commission. The Commission may on...

  5. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of...

  6. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 11 Federal Elections 1 2011-01-01 2011-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is to set forth rules informing the public as to what information is maintained by the Federal...

  7. 47 CFR 1.1 - Proceedings before the Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Proceedings before the Commission. 1.1 Section 1.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE General Rules of Practice and Procedure General § 1.1 Proceedings before the Commission. The Commission may on...

  8. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the...

  9. 11 CFR 1.1 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Purpose and scope. 1.1 Section 1.1 Federal Elections FEDERAL ELECTION COMMISSION PRIVACY ACT § 1.1 Purpose and scope. (a) The purpose of this part is to set forth rules informing the public as to what information is maintained by the Federal...

  10. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1... titles of the Code of Federal Regulations: • Regulations having HHS-wide application or which the...

  11. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of...

  12. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of...

  13. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the...

  14. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the...

  15. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of...

  16. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the...

  17. 17 CFR 1.50-1.51 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false 1.50-1.51 Section 1.50-1.51 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous §§ 1.50-1.51...

  18. 17 CFR 1.50-1.51 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false 1.50-1.51 Section 1.50-1.51 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous §§ 1.50-1.51...

  19. 17 CFR 1.50-1.51 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false 1.50-1.51 Section 1.50-1.51 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous §§ 1.50-1.51...

  20. 17 CFR 1.50-1.51 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false 1.50-1.51 Section 1.50-1.51 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous §§ 1.50-1.51...

  1. 17 CFR 1.50-1.51 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false 1.50-1.51 Section 1.50-1.51 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous §§ 1.50-1.51...

  2. 26 CFR 1.267(b)-1 - Relationships.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Relationships. 1.267(b)-1 Section 1.267(b)-1...) INCOME TAXES Items Not Deductible § 1.267(b)-1 Relationships. (a) In general. (1) The persons referred to... partnership separately. Therefore, if the other person and a partner are within any one of the...

  3. 26 CFR 1.148-1A - Definitions and elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Definitions and elections. 1.148-1A Section 1.148-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX....148-1A Definitions and elections. (a) . For guidance see § 1.148-1. (b) Certain...

  4. 26 CFR 1.281-1 - In general.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false In general. 1.281-1 Section 1.281-1 Internal... TAXES Terminal Railroad Corporations and Their Shareholders § 1.281-1 In general. Section 281 provides...” described in paragraph (c) of § 1.281-2 is not includable in gross income of the terminal...

  5. 38 CFR 1.780-1.783 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false 1.780-1.783 Section 1.780-1.783 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Homeless Claimants §§ 1.780-1.783 Part-Time Career Employment Program Source: 44 FR 55172, Sept. 25,...

  6. 38 CFR 1.780-1.783 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false 1.780-1.783 Section 1.780-1.783 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Homeless Claimants §§ 1.780-1.783 Part-Time Career Employment Program Source: 44 FR 55172, Sept. 25,...

  7. 38 CFR 1.780-1.783 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false 1.780-1.783 Section 1.780-1.783 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Homeless Claimants §§ 1.780-1.783 Part-Time Career Employment Program Source: 44 FR 55172, Sept. 25,...

  8. 38 CFR 1.780-1.783 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false 1.780-1.783 Section 1.780-1.783 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Homeless Claimants §§ 1.780-1.783 Part-Time Career Employment Program Source: 44 FR 55172, Sept. 25,...

  9. 38 CFR 1.780-1.783 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false 1.780-1.783 Section 1.780-1.783 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Homeless Claimants §§ 1.780-1.783 Part-Time Career Employment Program Source: 44 FR 55172, Sept. 25,...

  10. 45 CFR 1.1 - Location of HHS regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Location of HHS regulations. 1.1 Section 1.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HHS'S REGULATIONS § 1.1 Location of HHS regulations. Regulations for HHS's programs and activities are located in several different titles of the Code of Federal Regulations:...

  11. 26 CFR 1.6013-1 - Joint returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Joint returns. 1.6013-1 Section 1.6013-1...) INCOME TAXES (CONTINUED) Tax Returns Or Statements § 1.6013-1 Joint returns. (a) In general. (1) A husband and wife may elect to make a joint return under section 6013(a) even though one of the spouses...

  12. 26 CFR 1.6013-1 - Joint returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Joint returns. 1.6013-1 Section 1.6013-1...) INCOME TAXES (CONTINUED) Tax Returns Or Statements § 1.6013-1 Joint returns. (a) In general. (1) A husband and wife may elect to make a joint return under section 6013(a) even though one of the spouses...

  13. 26 CFR 1.6013-1 - Joint returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Joint returns. 1.6013-1 Section 1.6013-1...) INCOME TAXES (CONTINUED) Tax Returns Or Statements § 1.6013-1 Joint returns. (a) In general. (1) A husband and wife may elect to make a joint return under section 6013(a) even though one of the spouses...

  14. 26 CFR 1.6013-1 - Joint returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Joint returns. 1.6013-1 Section 1.6013-1...) INCOME TAXES Tax Returns Or Statements § 1.6013-1 Joint returns. (a) In general. (1) A husband and wife may elect to make a joint return under section 6013(a) even though one of the spouses has no...

  15. 26 CFR 1.6013-1 - Joint returns.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Joint returns. 1.6013-1 Section 1.6013-1...) INCOME TAXES (CONTINUED) Tax Returns Or Statements § 1.6013-1 Joint returns. (a) In general. (1) A husband and wife may elect to make a joint return under section 6013(a) even though one of the spouses...

  16. 26 CFR 1.56(g)-1 - Adjusted current earnings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Adjusted current earnings. 1.56(g)-1 Section 1.56(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Regulations Applicable to Taxable Years Beginning in 1969 and Ending in 1970 § 1.56(g)-1 Adjusted current earnings. (a) Adjustment for...

  17. 26 CFR 1.362-1 - Basis to corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Basis to corporations. 1.362-1 Section 1.362-1...) INCOME TAXES Effects on Corporation § 1.362-1 Basis to corporations. (a) In general. Section 362 provides, as a general rule, that if property was acquired on or after June 22, 1954, by a corporation (1)...

  18. 38 CFR 1.480-1.483 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false 1.480-1.483 Section 1.480-1.483 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Disclosures with Patient's Consent §§ 1.480-1.483 Disclosures Without Patient Consent...

  19. 38 CFR 1.480-1.484 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false 1.480-1.484 Section 1.480-1.484 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Disclosures with Patient's Consent §§ 1.480-1.484 Disclosures Without Patient Consent...

  20. 38 CFR 1.480-1.483 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false 1.480-1.483 Section 1.480-1.483 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Disclosures with Patient's Consent §§ 1.480-1.483 Disclosures Without Patient Consent...

  1. 38 CFR 1.480-1.483 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false 1.480-1.483 Section 1.480-1.483 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Disclosures with Patient's Consent §§ 1.480-1.483 Disclosures Without Patient Consent...

  2. 38 CFR 1.480-1.483 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false 1.480-1.483 Section 1.480-1.483 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Disclosures with Patient's Consent §§ 1.480-1.483 Disclosures Without Patient Consent...

  3. Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa).

    PubMed

    Ernstgård, Lena; Lind, Birger; Andersen, Melvin E; Johanson, Gunnar

    2010-01-01

    Blood-air and tissue-blood coefficients (lambda) are essential to characterize the uptake and disposition of volatile substances, e.g. by physiologically based pharmacokinetic (PBPK) modelling. Highly volatile chemicals, including many hydrofluorocarbons (HFC) have low solubility in liquid media. These characteristics pose challenges for determining lambda values. A modified head-space vial equilibrium method was used to determine lambda values for five widely used HFCs. The method is based on automated head-space gas chromatography and injection of equal amount of chemical in two head-space vials with identical air phase volumes but different volumes of the liquid phase. The liquids used were water (physiological saline), fresh human blood, and olive oil. The average lambda values (n = 8) were as follows: 1,1-difluoroethane (HFC152a) - 1.08 (blood-air), 1.11 (water-air) and 5.6 (oil-air); 1,1,1-trifluoroethane (HFC143a) - 0.15, 0.15 and 1.90; 1,1,1,2-tetrafluoroethane (HFC134a) - 0.36, 0.35 and 3.5; 1,1,1,2,2-pentafluoroethane (HFC125) - 0.083, 0.074 and 1.71; and 1,1,1,3,3-pentafluoropropane (HFC245fa) - 0.62, 0.58 and 12.1. The lambda values appeared to be concentration-independent in the investigated range (2-200 ppm). In spite of the low lambda values, the method errors were modest, with coefficients of variation of 9, 11 and 10% for water, blood and oil, respectively.

  4. GNAO1 encephalopathy

    PubMed Central

    Danti, Federica Rachele; Galosi, Serena; Romani, Marta; Montomoli, Martino; Carss, Keren J.; Raymond, F. Lucy; Parrini, Elena; Bianchini, Claudia; McShane, Tony; Dale, Russell C.; Mohammad, Shekeeb S.; Shah, Ubaid; Mahant, Neil; Ng, Joanne; McTague, Amy; Samanta, Rajib; Vadlamani, Gayatri; Valente, Enza Maria; Leuzzi, Vincenzo; Kurian, Manju A.

    2017-01-01

    Objective: To describe better the motor phenotype, molecular genetic features, and clinical course of GNAO1-related disease. Methods: We reviewed clinical information, video recordings, and neuroimaging of a newly identified cohort of 7 patients with de novo missense and splice site GNAO1 mutations, detected by next-generation sequencing techniques. Results: Patients first presented in early childhood (median age of presentation 10 months, range 0–48 months), with a wide range of clinical symptoms ranging from severe motor and cognitive impairment with marked choreoathetosis, self-injurious behavior, and epileptic encephalopathy to a milder phenotype, featuring moderate developmental delay associated with complex stereotypies, mainly facial dyskinesia and mild epilepsy. Hyperkinetic movements were often exacerbated by specific triggers, such as voluntary movement, intercurrent illnesses, emotion, and high ambient temperature, leading to hospital admissions. Most patients were resistant to drug intervention, although tetrabenazine was effective in partially controlling dyskinesia for 2/7 patients. Emergency deep brain stimulation (DBS) was life saving in 1 patient, resulting in immediate clinical benefit with complete cessation of violent hyperkinetic movements. Five patients had well-controlled epilepsy and 1 had drug-resistant seizures. Structural brain abnormalities, including mild cerebral atrophy and corpus callosum dysgenesis, were evident in 5 patients. One patient had a diffuse astrocytoma (WHO grade II), surgically removed at age 16. Conclusions: Our findings support the causative role of GNAO1 mutations in an expanded spectrum of early-onset epilepsy and movement disorders, frequently exacerbated by specific triggers and at times associated with self-injurious behavior. Tetrabenazine and DBS were the most useful treatments for dyskinesia. PMID:28357411

  5. Crystalline 1H-1,2,3-triazol-5-ylidenes

    SciTech Connect

    Bertrand, Guy; Gulsado-Barrios, Gregorio; Bouffard, Jean; Donnadieu, Bruno

    2016-08-02

    The present invention provides novel and stable crystalline 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of making 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of using 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes in catalytic reactions.

  6. Direct evidence for functional TRPV1/TRPA1 heteromers.

    PubMed

    Fischer, Michael J M; Balasuriya, Dilshan; Jeggle, Pia; Goetze, Tom A; McNaughton, Peter A; Reeh, Peter W; Edwardson, J Michael

    2014-12-01

    Transient receptor potential cation channel, subfamily V, member 1 (TRPV1) plays a key role in sensing environmental hazards and in enhanced pain sensation following inflammation. A considerable proportion of TRPV1-expressing cells also express transient receptor potential cation channel, subfamily A, member 1 (TRPA1). There is evidence for a TRPV1-TRPA1 interaction that is predominantly calcium-dependent, and it has been suggested that the two proteins might form a heteromeric channel. Here, we constructed subunit concatemers to search for direct evidence for such an interaction. We found that a TRPV1::TRPV1 concatemer and TRPV1 formed channels with similar properties. A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists. Isolated TRPV1 and TRPV1::TRPA1 imaged by atomic force microscopy (AFM) both had molecular volumes consistent with the formation of tetrameric channels. Antibodies decorated epitope tags on TRPV1 with a four-fold symmetry, as expected for a homotetramer. In contrast, pairs of antibodies decorated tags on TRPV1::TRPA1 predominantly at 180°, indicating the formation of a channel consisting of two TRPV1::TRPA1 concatemers arranged face to face. TRPV1::TRPA1 was sensitized by PKC activation and could be inhibited by a TRPV1 antagonist. TRPV1::TRPA1 was activated by heat and displayed a threshold and temperature coefficient similar to TRPV1. However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. We conclude that the presence of TRPA1 exerts a functional inhibition on TRPV1.

  7. 78 FR 79007 - 1,1,1,2-Tetrafluoroethane From China

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... COMMISSION 1,1,1,2-Tetrafluoroethane From China Determinations On the basis of the record \\1\\ developed in... reason of imports from China of 1,1,1,2- Tetrafluoroethane, provided for in subheadings 2903.39.20 of the... the Government of China. \\1\\ The record is defined in sec. 207.2(f) of the Commission's Rules...

  8. ION-1 technical manual

    SciTech Connect

    Halbig, J.K.; Caine, J.C.

    1985-07-01

    The portable gamma-ray and neutron detector electronics (ION-1) gives a digital readout of the current-mode response produced by gamma rays in an ion chamber and of amplification and scaling of pulses received from a neutron detector. The primary application is the measurement of gamma-ray and neutron activity of irradiated reactor fuels stored at a reactor or at a storage pond away from a reactor. ION-1 is the first such instrument to use a design that allows communication of procedures, response, and results between instrument and inspector. It prompts the inspector through procedures, carries out programmed measurement steps, calculates results and error estimates, and performs internal diagnostic checks. This Technical Manual describes adjustment procedures and limited technical information that enable the inspector to troubleshoot at the board level. 5 figs., 10 tabs.

  9. 1,4-Bis(imidazol-1-yl)benzene–terephthalic acid (1/1)

    PubMed Central

    Zhang, Shiyong; Tang, Yurong; Mao, Zhihua; Li, Mingliang; Lan, Jingbo; Su, Xiaoyu

    2009-01-01

    In the title compound, C12H10N4·C8H6O4, 1,4-bis­(imidazol-1-yl)benzene and terephthalic acid mol­ecules are joined via strong O—H⋯N hydrogen bonds to form infinite zigzag chains. Both mol­ecules are located on crystallographic inversion centers. The O—H⋯N hydrogen-bonded chains are assembled into two-dimensional layers through weak C—H⋯O and strong π–π stacking inter­actions [centroid–centroid distance = 3.818 (2) Å], leading to the formation of a three-dimensional supra­molecular structure. PMID:21581669

  10. CROSSBOW. Volume 1

    DTIC Science & Technology

    2001-12-01

    Budget, Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE 18 October 2002 3. REPORT TYPE AND... asymmetric threats. Similar asymmetric threats could be used against high-value naval assets. In addition to asymmetric threats, results from the campaign...of future combat operations. f. Logistical Issues Due to reduction in U.S. overseas bases, CROSSBOW forces will have to rely on self-sustained

  11. Quantitative Risk - Phase 1

    DTIC Science & Technology

    2013-09-03

    040 Report No. SERC-2013-TR-040-2 Revised September 3, 2013 73 189. Mockus, A., Weiss, D., “Predicting Risk of Software Changes”, Bell Labs...the Council for International Organizations of Medical Sciences (CIOMS), 1998 238. Thompson, K., Graham , J., Zellner, J., “Risk-Benefit Analsis...International Journal on Engineering Performance-Based Fire Codes, Volume 6, Number 1, 2004 254. Bell , J., Holroyd, J., “Review of human reliability

  12. Applied N=1 Supergravity

    NASA Astrophysics Data System (ADS)

    Nath, Pran

    A review of recent developments in the applications of N=1 Supergravity to the construction of unified models of elementary particle interactions is given. Couplings of N=1 Supergravity with matter consisting of an arbitrary set of l handed multiplets and a gauge multiplet are discussed. General formulation of spontaneous symmetry breaking and the criteria for breaking of internal symmetry and of local supersymmetry are described. Construction of specific Supergrvity GUT models, the gauge heirarchy in GUT models and a deduction of the low energy effective potential are discussed. The phenomena of SU(2)XU(1) electro-weak gauge invariance breakdown by Supergravity in tree models and by radiative corrections using renormalization group methods are described. Model independent formulations of low energy physics which encompass tree and the renormalization group methods of breaking SU(2)XU(1), but also allow more general scenarios are discussed. The particle content of Supergravity unified theories at low energy is given which includes predictions, for a class of supergravity models, of light gauge fermins, i.e. of a charged Dirac fermion, the Wino, with a mass below the W boson mass and a neutral fermion, the Zino, below the mass of the Z boson mass. "Direct" gaugino masses arising from loops for the photino and the gluino, (which are massless at the tree level) are exhibited. Decays of the W and Z into photino. Vino, and Zino modes and their branching ratios into various channels are given. Experimental signals for the supersymmetrie decays are discussed and some prominent signatures such as decays into one and two jets with unbalanced energy and momentum are pointed out. The current status of the ρ-parameter, including supergravity GUT effects is given. Other experimental consequences of supergravity unified theories are also discussed.

  13. Geothermal district G1

    SciTech Connect

    Not Available

    1988-12-01

    Geothermal District G1 includes 37 northeastern California counties and six geothermal fields: Lake City, Susanville, Litchfield, Wendel, Amedee, and Casa Diablo. Electrical generation from geothermal resources occurs in three of the fields: Wendel, Amedee, and Casa Diablo. Low-temperature geothermal projects are underway throughout the district and are described in a road log format. The ten projects described are located at Big Bend, Glass Mountain, Bieber, Alturas, Cedarville, Lake City, Honey Lake Valley, Greenville, and in Sierra and Mono Counties.

  14. Chapter 1: Introduction

    SciTech Connect

    None, None

    2009-01-18

    The Office of Energy Efficiency and Renewable Energy (EERE) develops–and encourages consumers and business to adopt–technologies that improve energy efficiency and increase the use of renewable energy. This report describes analysis undertaken by EERE to better understand the extent to which the technologies and market improvements funded by its FY 2004 Budget Request1 will make energy more affordable, cleaner, and more reliable.

  15. Metabolism of Monoterpenes 1

    PubMed Central

    Croteau, Rodney; El-Bialy, Hamdy; Dehal, Shangara S.

    1987-01-01

    The bicyclic monoterpene ketone (+)-camphor undergoes lactonization to 1,2-campholide in mature sage (Salvia officinalis L.) leaves followed by conversion to the β-d-glucoside-6-O-glucose ester of the corresponding hydroxy acid (1-carboxymethyl-3-hydroxy-2,2,3-trimethyl cyclopentane). Analysis of the disposition of (+)-[G-3H]camphor applied to midstem leaves of intact flowering plants allowed the kinetics of synthesis of the bis-glucose derivative and its transport from leaf to root to be determined, and gave strong indication that the transport derivative was subsequently metabolized in the root. Root extracts were shown to possess β-glucosidase and acyl glucose esterase activities, and studies with (+)-1,2[U-14C]campholide as substrate, using excised root segments, revealed that the terpenoid was converted to lipid materials. Localization studies confirmed the radiolabeled lipids to reside in the membranous fractions of root extracts, and analysis of this material indicated the presence of labeled phytosterols and labeled fatty acids (C14 to C20) of acyl lipids. Although it was not possible to detail the metabolic steps between 1,2-campholide and the acyl lipids and phytosterols derived therefrom because of the lack of readily detectable intermediates, it seemed likely that the monoterpene lactone was degraded to acetyl CoA which was reincorporated into root membrane components via standard acyl lipid and isoprenoid biosynthetic pathways. Monoterpene catabolism thus appears to represent a salvage mechanism for recycling mobile carbon from senescing oil glands on the leaves to the roots. PMID:16665495

  16. SEDSAT-1 Technology Development

    NASA Technical Reports Server (NTRS)

    Maier, Mark W.; Wells, B. Earl

    1996-01-01

    The Students for the Exploration and Development of Space Satellite (SEDSAT-1) is an ambitious project to design, build, and fly a generally-accessible low-cost satellite which will 1) act as a technology demonstration to verify the suitability of novel optical, battery, microprocessor, and memory hardware for space flight environments, (2) to advance the understanding of tether dynamics and environmental science through the development of advanced imaging experiments, (3) to act as a communication link for radio amateurs, and (4) to provide graduate and undergraduate students with a unique multi-disciplinary experience in designing complex real-world hardware/software. This report highlights the progress made on this project during the time period from January 2, 1996 to June 1, 1996 at the end of which time the SEASIS 0.7 version software was completed and integrated on the SEASIS breadboard, a functional prototype of the Panoramic Annual Lenses (PAL) camera was developed, the preferred image compression technique was selected, the layout of the SEASIS board was begun, porting of the SCOS operating system to the command data system (CDS) board was begun, a new design for a tether release mechanism was developed, safety circuitry to inhibit tether cutting was developed and prototyped, material was prepared to support a comprehensive safety review of the project which was held at Johnson Space Center (JSC) (which was personally attended by one of the Principal Investigators), and prototype ground software was developed.

  17. Maturation in Larch 1

    PubMed Central

    Greenwood, Michael S.; Hopper, Catherine A.; Hutchison, Keith W.

    1989-01-01

    The time course of maturation in eastern larch (Larix laricina [Du Roi] K. Koch) was examined by grafting scions from trees of different ages onto 2-year-old root stock and following scion development for several years. Height, diameter, foliar chlorophyll content, and rooting ability of scion-derived cuttings all varied linearly as a function of log10 age. Chlorophyll content (milligrams per gram of dry weight) increased while height, diameter, and ability to root decreased with age (P < 0.01). The tendency toward orthotropic growth and branch formation per centimeter of main stem decreased abruptly between age 1 and 5 years (P < 0.01). Total chlorophyll content of both long and short shoot foliage increased by 30 to 50% with increasing age, but the chlorophyll a/b ratio did not change. Also, juvenile long shoot needles were significantly longer than mature (P < 0.01). Surprisingly, the juvenile scions produced more total strobili over two successive years, but the mature scions produced a significantly higher proportion of male strobili (P < 0.001 year 1; P < 0.02 year 2). The age-related changes in foliar traits were not associated with changes in DNA methylation between juvenile and mature scions. Using HPLC, we found that 20% of foliar DNA cytosine residues were methylated in both scion types. Images Figure 1 PMID:16666785

  18. Cardiac T1 Imaging

    PubMed Central

    Jerosch-Herold, Michael; Kwong, Raymond Y.

    2014-01-01

    T1 mapping of the heart has evolved into a valuable tool to evaluate myocardial tissue properties, with or without contrast injection, including assessment of myocardial edema and free water content, extra-cellular volume (expansion), and most recently cardiomyocyte hypertrophy. The MRI pulse sequence techniques developed for these applications have had to address at least two important considerations for cardiac applications: measure magnetization inversion recoveries during cardiac motion with sufficient temporal resolution for the shortest expected T1 values, and, secondly, obtain these measurements within a time during which a patient can comfortably suspend breathing. So-called Look-Locker techniques, and variants thereof, which all sample multiple points of a magnetization recovery after each magnetization preparation have therefore become a mainstay in this field. The rapid pace of advances and new findings based on cardiac T1 mapping for assessment of diffuse fibrosis, or myocardial edema show that these techniques enrich the capabilities of MRI for myocardial tissue profiling, which is arguably unmatched by other cardiac imaging modalities. PMID:24509619

  19. Vitiligo - Part 1*

    PubMed Central

    Tarlé, Roberto Gomes; do Nascimento, Liliane Machado; Mira, Marcelo Távora; de Castro, Caio Cesar Silva

    2014-01-01

    Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects melanocytes from epidermis basal layer, leading to the development of hypochromic and achromic patches. Its estimated prevalence is 0.5% worldwide. The involvement of genetic factors controlling susceptibility to vitiligo has been studied over the last decades, and results of previous studies present vitiligo as a complex, multifactorial and polygenic disease. In this context, a few genes, including DDR1, XBP1 and NLRP1 have been consistently and functionally associated with the disease. Notwithstanding, environmental factors that precipitate or maintain the disease are yet to be described. The pathogenesis of vitiligo has not been totally clarified until now and many theories have been proposed. Of these, the autoimmune hypothesis is now the most cited and studied among experts. Dysfunction in metabolic pathways, which could lead to production of toxic metabolites causing damage to melanocytes, has also been investigated. Melanocytes adhesion deficit in patients with vitiligo is mainly speculated by the appearance of Köebner phenomenon, recently, new genes and proteins involved in this deficit have been found. PMID:24937821

  20. Indico 1.0

    NASA Astrophysics Data System (ADS)

    Gonzalez Lopez, J. B.; Avilés, A.; Baron, T.; Ferreira, P.; Kolobara, B.; Pugh, M. A.; Resco, A.; Trzaskoma, J. P.

    2014-06-01

    Indico has evolved into the main event organization software, room booking tool and collaboration hub for CERN. The growth in its usage has only accelerated during the past 9 years, and today Indico holds more that 215,000 events and 1,100,000 files. The growth was also substantial in terms of functionalities and improvements. In the last year alone, Indico has matured considerably in 3 key areas: enhanced usability, optimized performance and additional features, especially those related to meeting collaboration. Along the course of 2012, much activity has centred around consolidating all this effort and investment into "version 1.0", recently released in 2013.Version 1.0 brings along new features, such as the Microsoft Exchange calendar synchronization for participants, many new and clean interfaces (badges and poster generation, list of contributions, abstracts, etc) and so forth. But most importantly, it brings a message: Indico is now stable, consolidated and mature after more than 10 years of non-stop development. This message is addressed not only to CERN users but also to the many organisations, in or outside HEP, which have already installed the software, and to others who might soon join this community. In this document, we describe the current state of the art of Indico, and how it was built. This does not mean that the Indico software is complete, far from it! We have plenty of new ideas and projects that we are working on and which we have shared during CHEP 2013.

  1. AMF 1 Site Science

    SciTech Connect

    Miller, Mark Alan

    2016-08-18

    This report documents progress on DOE Grant# DE-FG02-08ER64531 funded by the Department of Energy’s Atmospheric Systems Research (ASR) program covering the period between its inception in 2008 and its conclusion in 2014. The Atmospheric Radiation Measurement (ARM) Program’s Mobile Facility #1 (AMF#1) is a collection of state-of-the art atmospheric sensing systems including remote and in situ instrumentation designed to characterize the atmospheric column above and in the immediate vicinity of the deployment location. The grant discussed in this report funded the activities of the AMF#1 Site Scientist Team. Broad responsibilities of this team included examining new deployment sites and recommending instrument deployment configurations; data quality control during the early stages of deployments and for certain instruments through the course of the deployment; scientific outreach in the host country or location (particularly international deployments); scientific research oriented toward basic questions about cloud physics and radiation transfer in the deployment region; and training of Ph.D. students to conduct future research relevant to the Atmospheric Systems Research (ASR) program.

  2. An investigation into the direct and indirect venoconstrictor effects of endothelin-1 and big endothelin-1 in man.

    PubMed Central

    Haynes, W G; Moffat, S; Webb, D J

    1995-01-01

    1. Endothelin-1 is a potent endothelium-derived vasoconstrictor peptide that is generated through cleavage of its precursor big endothelin-1 by 'endothelin converting enzyme' (ECE) in resistance vessels, including those of the forearm vascular bed. In some animal tissues, but not in resistance vessels of healthy human subjects, endothelin-1 appears to potentiate the actions of the sympathetic nervous system. We examined whether ECE activity is present in human hand veins and whether endothelin-1 or big endothelin-1 potentiate sympathetically mediated venoconstriction. 2. Six healthy subjects received dorsal hand vein infusion of local, non-systemic doses of endothelin-1 (5 pmol min-1), big endothelin-1 (50 pmol min-1) and, as a control, sodium chloride (0.9%; w/v) for 90 min. Vein diameter was measured using the Aellig displacement technique. Sympathetically mediated venoconstriction was elicited using the single deep breath reflex. 3. Endothelin-1 caused a progressive decrease in hand vein diameter, by 49% at 90 min (95% confidence intervals [CI]: -68 to -30%; P = 0.0001). Vein diameter did not change significantly after 90 min infusion of big endothelin-1 (+3%; CI: -11 to +17%; P = 0.0007 vs endothelin-1; P = 0.40 vs baseline) or sodium chloride (+2%; CI: -12 to +16%; P = 0.0002 vs endothelin-1; P = 0.60 vs baseline). Venoconstriction to deep breath was not potentiated by endothelin-1. 4. These results suggest that, in contrast to the situation in forearm resistance vessels, there is little or no local ECE activity in human hand veins and that endothelin does not potentiate sympathetic responses in these cutaneous capacitance vessels. PMID:8554931

  3. MinNorm approximation of MaxEnt/MinDiv problems for probability tables

    NASA Astrophysics Data System (ADS)

    Bogaert, Patrick; Gengler, Sarah

    2015-01-01

    Categorical data are found in a wide variety of important applications in environmental sciences and dealing with multivariate analyses is a challenging topic. Rebuilding a multivariate probability table becomes an issue and is expected to lead to poor probability estimates when a very limited number of samples are at hand. In order to take into account the lack of data, the information can be rewritten as inequality constraints instead of using the few sampled values as direct probability estimates. There is thus a need for an efficient method that allows us to rebuild a multivariate probability table from equalities and inequalities constraints. Rebuilding a probability function from equalities constraints can be done through a classical maximum entropy (MaxEnt) methodology. MaxEnt problem can be implemented by using iterated minimum norm (MinNorm) approximations. Minimum divergence (MinDiv) methodology extends the problem to the case of inequalities constraints and, again, MinNorm approximations can be applied and iterated. Thus, iterated MinNorm approximations are a fast and efficient way to combine equalities and inequalities constraints to rebuild a multivariate probability table. MinNorm methodology for solving problems involving both equalities and inequalities constraints can be applied in a wide variety of applications. MinNorm approximations become useful, for instance, when only few data are available or when taking into account experts opinion rewritten as equalities and inequalities constraints is of prime interest in probability estimates. An example in environmental sciences is presented in order to illustrate the benefits of the methodology.

  4. 26 CFR 1.815-1 - Taxable years affected.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) INCOME TAXES Distributions to Shareholders § 1.815-1 Taxable years affected. Sections 1.815-2 through 1... Internal Revenue Code of 1954, as amended by the Life Insurance Company Income Tax Act of 1959 (73...

  5. Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1.

    PubMed

    Narukawa, Masataka; Koizumi, Kanako; Iwasaki, Yusaku; Kubota, Kikue; Watanabe, Tatsuo

    2010-01-01

    We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

  6. 26 CFR 1.864-1 - Meaning of sale, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Meaning of sale, etc. 1.864-1 Section 1.864-1...) INCOME TAXES Regulations Applicable to Taxable Years Prior to December 30, 1996 § 1.864-1 Meaning of sale, etc. For purposes of §§ 1.861 through 1.864-7, the word “sale” includes “exchange”; the word...

  7. Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma.

    PubMed

    Kaminagakura, E; Caris, A; Coutinho-Camillo, C; Soares, F A; Takahama-Júnior, A; Kowalski, L P

    2016-06-01

    The purpose of this study was to evaluate the expression of the enzymes involved in the biotransformation of tobacco and alcohol. A study group of 41 young patients (≤40 years old) with oral squamous cell carcinoma (OSCC) was compared to 59 control subjects (≥50 years old) with tumours of similar clinical stages and topographies. The immunohistochemical expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 was evaluated using the tissue microarray technique. There was a predominance of males, smokers, and alcohol drinkers in both groups. Most tumours were located in the tongue (43.9% vs. 50.8%), were well-differentiated (63.4% vs. 56.6%), and were in clinical stages III or IV (80.5% vs. 78.0%). No difference was observed in the expression of CYP1A1, ALDH1A1, or ALDH2 between the two groups. CYP1A1 and ALDH2 protein expression had no influence on the prognosis. The immunoexpression of CYP1B1 was significantly higher in the control group than in the young group (P<0.001). The 5-year relapse-free survival was better in patients with CYP1B1 overexpression vs. protein underexpression (64% vs. 25%; P<0.05), regardless of age. ALDH1A1 expression improved relapse-free survival in young patients. These results suggest a lower risk of recurrence with increased metabolism of carcinogens by CYP1B1. Further studies involving other genes and proteins are necessary to complement the results of this research.

  8. 26 CFR 1.675-1 - Administrative powers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Administrative powers. 1.675-1 Section 1.675-1...) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.675-1 Administrative powers. (a... the trust. If a grantor retains a power to amend the administrative provisions of a trust...

  9. 26 CFR 1.682(c)-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Definitions. 1.682(c)-1 Section 1.682(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Miscellaneous § 1.682(c)-1 Definitions. For definitions of the terms “husband” and “wife”...

  10. 26 CFR 1.704-1T - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false 1.704-1T Section 1.704-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Partners and Partnerships § 1.704-1T...

  11. 26 CFR 1.704-1T - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false 1.704-1T Section 1.704-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Partners and Partnerships § 1.704-1T...

  12. 26 CFR 1.884-1 - Branch profits tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Branch profits tax. 1.884-1 Section 1.884-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Foreign Corporations § 1.884-1 Branch profits tax. (a) General rule. A foreign corporation shall be liable for a branch profits tax...

  13. 26 CFR 1.884-1 - Branch profits tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Branch profits tax. 1.884-1 Section 1.884-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Corporations § 1.884-1 Branch profits tax. (a) General rule. A foreign corporation shall be liable for a...

  14. 26 CFR 1.7701(l)-1 - Conduit financing arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Conduit financing arrangements. 1.7701(l)-1 Section 1.7701(l)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations § 1.7701(l)-1 Conduit...

  15. 26 CFR 1.7701(l)-1 - Conduit financing arrangements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Conduit financing arrangements. 1.7701(l)-1 Section 1.7701(l)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations § 1.7701(l)-1...

  16. 26 CFR 1.7701(l)-1 - Conduit financing arrangements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Conduit financing arrangements. 1.7701(l)-1 Section 1.7701(l)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations § 1.7701(l)-1...

  17. 26 CFR 1.7701(l)-1 - Conduit financing arrangements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

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