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  1. USGS 1-min Dst index

    USGS Publications Warehouse

    Gannon, J.L.; Love, J.J.

    2011-01-01

    We produce a 1-min time resolution storm-time disturbance index, the USGS Dst, called Dst8507-4SM. This index is based on minute resolution horizontal magnetic field intensity from low-latitude observatories in Honolulu, Kakioka, San Juan and Hermanus, for the years 1985-2007. The method used to produce the index uses a combination of time- and frequency-domain techniques, which more clearly identifies and excises solar-quiet variation from the horizontal intensity time series of an individual station than the strictly time-domain method used in the Kyoto Dst index. The USGS 1-min Dst is compared against the Kyoto Dst, Kyoto Sym-H, and the USGS 1-h Dst (Dst5807-4SH). In a time series comparison, Sym-H is found to produce more extreme values during both sudden impulses and main phase maximum deviation, possibly due to the latitude of its contributing observatories. Both Kyoto indices are shown to have a peak in their distributions below zero, while the USGS indices have a peak near zero. The USGS 1-min Dst is shown to have the higher time resolution benefits of Sym-H, while using the more typical low-latitude observatories of Kyoto Dst. ?? 2010.

  2. Changes to MFRSRCLDOD1MIN Datastream

    SciTech Connect

    S McFarlane and Y Shi

    2012-05-23

    Significant updates were made to the multifilter rotating shadowband radiometer (MFRSR) cloud optical depth (MFRSRCLDOD) value-added product (VAP) in 2011. The original intent of the update was to add quality control (QC) flags and to update the VAP to use the improved retrievals of liquid water path (LWP) from the Microwave Radiometer Retrievals (MWRRET) VAP rather than the statistical retrievals of LWP from the Microwave Radiometer Line of Sight (MWRLOS) datastream. Although this was originally intended to be a straightforward update of the code, it became more complicated due to the following factors: (1) a new developer and translator team were working with the code; (2) numerous small changes had to be made to the code to consistently implement the QC flags; and (3) ARM standards have changed over the years since the code was originally developed.

  3. Achieving 1% NMR polarization in water in less than 1 min using SABRE

    PubMed Central

    Zeng, Haifeng; Xu, Jiadi; McMahon, Michael T.; Lohman, Joost A.B.; van Zijl, Peter C.M.

    2015-01-01

    The development of biocompatible hyperpolarized media is a crucial step towards application of hyperpolarization in vivo. This article describes the achievement of 1% hyperpolarization of 3-amino-1,2,4-triazine protons in water using the parahydrogen induced polarization technique based on signal amplification by reversible exchange (SABRE). Polarization was achieved in less than 1 min. PMID:25123540

  4. Loss of Rassf1a co-operates with ApcMin to accelerate intestinal tumourigenesis

    PubMed Central

    van der Weyden, L.; Arends, M.J.; Dovey, O.M.; Harrison, H. L.; Lefebvre, G.; Conte, N.; Gergely, F.V.; Bradley, A.; Adams, D.J.

    2013-01-01

    Promoter methylation of the RAS-association domain family 1, isoform A gene (RASSF1A) is one of the most frequent events found in human tumours. In this study we set out to test the hypothesis that loss of Rassf1a can co-operate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using the Apc-Min (ApcMin/+) mouse model, as mutational or deletional inactivation of APC is a frequent early event in the genesis of intestinal cancer. Further, loss of RASSF1A has also been reported to occur in premalignant adenomas of the bowel. RASSF1A has been implicated in an array of pivotal cellular processes, including regulation of the cell cycle, apoptosis, microtubule stability and most recently in the β-catenin signalling pathway. By interbreeding isoform specific Rassf1a knockout mice with Apc+/Min mice we showed that loss of Rassf1a results in a significant increase in adenomas of the small intestine and accelerated intestinal tumourigenesis leading to the earlier death of adenocarcinoma-bearing mice and decreased overall survival. Comparative genomic hybridization of adenomas from Rassf1a−/−; Apc+/Min mice revealed no evidence of aneuploidy or gross chromosomal instability (no difference to adenomas from Rassf1a+/+; Apc+/Min mice). Immunohistochemical analysis of adenomas revealed increased nuclear β-catenin accumulation in adenomas from Rassf1a−/−; Apc+/Min mice, compared to those from Rassf1a+/+; Apc+/Min mice, but no differences in proliferation marker (Ki67) staining patterns. Collectively these data demonstrate co-operation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis, with adenomas showing increased nuclear accumulation of β-catenin, supporting a mechanistic link via loss of the known interaction of Rassf1 with β-TrCP that usually mediates degradation of β-catenin. PMID:18391979

  5. Regulation of the Kv2.1 potassium channel by MinK and MiRP1

    PubMed Central

    McCrossan, Zoe A.; Roepke, Torsten K.; Lewis, Anthony; Panaghie, Gianina; Abbott, Geoffrey W.

    2010-01-01

    Kv2.1 is a voltage-gated potassium (Kv) channel α subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single transmembrane domain ancillary subunits that form complexes with Kv channel α subunits to modify their function. Mutations in human MinK (KCNE1) and MiRP1 (KCNE2) are associated with inherited and acquired forms of long QT syndrome (LQTS). Here, co-immunoprecipitations from rat heart tissue suggested that both MinK and MiRP1 form native cardiac complexes with Kv2.1. In whole-cell voltage clamp studies of subunits expressed in CHO cells, rat MinK and MiRP1 reduced Kv2.1 current density 3- and 2-fold respectively, slowed Kv2.1 activation (at +60 mV) 2- and 3-fold respectively, and each slowed Kv2.1 deactivation <2-fold. Human MinK slowed Kv2.1 activation 25%, while human MiRP1 slowed Kv2.1 activation and deactivation 2-fold. Inherited mutations in human MinK and MiRP1, previously associated with LQTS, were also evaluated. D76N-MinK and S74L-MinK reduced Kv2.1 current density (3-fold and 40%, respectively) and slowed deactivation (60 and 80%, respectively). Compared to wild-type human MiRP1-Kv2.1 complexes, channels formed with M54T- or I57T-MiRP1 showed greatly slowed activation (10-fold and 5-fold, respectively). The data broaden the potential roles of MinK and MiRP1 in cardiac physiology and support the possibility that inherited mutations in either subunit could contribute to cardiac arrhythmia by multiple mechanisms. PMID:19219384

  6. Global statistical maps of extreme-event magnetic observatory 1 min first differences in horizontal intensity

    NASA Astrophysics Data System (ADS)

    Love, Jeffrey J.; Coïsson, Pierdavide; Pulkkinen, Antti

    2016-05-01

    Analysis is made of the long-term statistics of three different measures of ground level, storm time geomagnetic activity: instantaneous 1 min first differences in horizontal intensity ΔBh, the root-mean-square of 10 consecutive 1 min differences S, and the ramp change R over 10 min. Geomagnetic latitude maps of the cumulative exceedances of these three quantities are constructed, giving the threshold (nT/min) for which activity within a 24 h period can be expected to occur once per year, decade, and century. Specifically, at geomagnetic 55°, we estimate once-per-century ΔBh, S, and R exceedances and a site-to-site, proportional, 1 standard deviation range [1 σ, lower and upper] to be, respectively, 1000, [690, 1450]; 500, [350, 720]; and 200, [140, 280] nT/min. At 40°, we estimate once-per-century ΔBh, S, and R exceedances and 1 σ values to be 200, [140, 290]; 100, [70, 140]; and 40, [30, 60] nT/min.

  7. Rain rate modeling of 1-min from various integration times in South Korea.

    PubMed

    Shrestha, Sujan; Park, Jung-Jin; Choi, Dong-You

    2016-01-01

    Rain plays a major impairment factor for propagation of electromagnetic waves in atmosphere for systems operating at frequencies above 10 GHz. Several effects are noted such as depolarization, scintillation, interference due to scattering and extra attenuation which seems to increase with frequency. To mitigate its effect in satellite communication, knowledge of local rainfall statistics is necessary which act as milestone for design of radio link. Rain attenuation is best visualize by the 1-min rainfall rate statistic but the measurement of this rain rate distribution is rare on a worldwide basis and observation of rain rate are done with longer integration times typically 30 min or more. In this paper, efforts have been made to develop model that can convert rain rate complementary cumulative distribution function to shorter integration times. The average relative error margin of about 5, 14, 43, 71 and 115 % are noted for 5 to 1-, 10 to 1-, 20 to 1, 30 to 1- and 60 to 1-min respectively from ITU-R P.837-6 method which have been analyzed in further section of this article. The empirical natures of conversion methods as such Segal method, Burgueno's method, Chebil and Rahman method and Logarithmic model are studied along with the proposed new model that seems to be applicable in derivation of 1-min rain rate of the South Korea rain rate statistics. International Telecommunication Union-Radio communication Sector (ITU-R) has developed a recommendation ITU-R P.837-6 that enables the user to estimate the local 1-min rainfall rate statistical distribution which is compared with calculated 1-min rain rate distribution from experimental 1-min rainfall accumulation. Unfortunately, ITU-R P.837-6 estimated 1-min values show greater error percentages. In order to get better approximation of local 1-min rain rate estimation, a novel method is proposed and it's efficiency have been compared with rainfall rate statistics obtained from nine different locations in the South

  8. Serpine1 Mediates Porphyromonas gingivalis Induced Insulin Secretion in the Pancreatic Beta Cell Line MIN6

    PubMed Central

    Bhat, Uppoor G.; Watanabe, Keiko

    2015-01-01

    Periodontitis is an inflammatory disease resulting in destruction of gingiva and alveolar bone caused by an exuberant host immunological response to periodontal pathogens. Results from a number of epidemiological studies indicate a close association between diabetes and periodontitis. Results from cross-sectional studies indicate that subjects with periodontitis have a higher odds ratio of developing insulin resistance (IR). However, the mechanisms by which periodontitis influences the development of diabetes are not known. Results from our previous studies using an animal model of periodontitis suggest that periodontitis accelerates the onset of hyperinsulinemia and IR. In addition, LPS from a periodontal pathogen, Porphyromonas gingivalis (Pg), stimulates Serpine1 expression in the pancreatic beta cell line MIN6. Based on these observations, we hypothesized that a periodontal pathogen induces hyperinsulinemia and Serpine1 may be involved in this process. To test this hypothesis, we co-incubated Pg with the pancreatic beta cell line MIN6 and measured the effect on insulin secretion by MIN6 cells. We further determined the involvement of Serpine1 in insulin secretion by downregulating Serpine1 expression. Our results indicated that Pg stimulated insulin secretion by approximately 3.0 fold under normoglycemic conditions. In a hyperglycemic state, Pg increased insulin secretion by 1.5 fold. Pg significantly upregulated expression of the Serpine1 gene and this was associated with increased secretion of insulin by MIN6 cells. However, cells with downregulated Serpine1 expression were resistant to Pg stimulated insulin secretion under normoglycemic conditions. We conclude that the periodontal pathogen, Pg, induced insulin secretion by MIN6 cells and this induction was, in part, Serpine1 dependent. Thus, Serpine1 may play a pivotal role in insulin secretion during the accelerated development of hyperinsulinemia and the resulting IR in the setting of periodontitis. PMID

  9. Splitting of the m=n=1 modes in hybrids with q{sub min}<1

    SciTech Connect

    Marchenko, V. S.; Reznik, S. N.

    2010-08-15

    The frequency splitting between m=n=1 eigenmodes in tokamak discharges with two q=1 surfaces and sheared toroidal rotation has been calculated. The instability domain of the ''doublet'' in the parameter space has been established for the first time. The results are consistent with observations of the frequency splitting in ASDEX Upgrade [O. Gruber et al., Nucl. Fusion 39, 1321 (1999)] and DIII-D [J. Luxon, Nucl. Fusion 42, 614 (2002)] tokamaks.

  10. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells

    PubMed Central

    Wauson, Eric M.; Guerra, Marcy L.; Dyachok, Julia; McGlynn, Kathleen; Giles, Jennifer; Ross, Elliott M.

    2015-01-01

    The MAPKs ERK1/2 respond to nutrients and other insulin secretagogues in pancreatic β-cells and mediate nutrient-dependent insulin gene transcription. Nutrients also stimulate the mechanistic target of rapamycin complex 1 (mTORC1) to regulate protein synthesis. We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic β-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor. We show here that AAs differentially activate these two signaling pathways in MIN6 cells. Pretreatment with pertussis toxin did not prevent the activation of either ERK1/2 or mTORC1 by AAs, indicating that Gi is not central to either pathway. Although glucagon-like peptide 1, an agonist for a Gs-coupled receptor, activated ERK1/2 well and mTORC1 to a small extent, AAs had no effect on cytosolic cAMP accumulation. Ca2+ entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1. Pretreatment with UBO-QIC, a selective Gq inhibitor, reduced the activation of ERK1/2 but had little effect on the activation of mTORC1 by AAs, suggesting a differential requirement for Gq. Inhibition of G12/13 by the overexpression of the regulator of G protein signaling domain of p115 ρ-guanine nucleotide exchange factor had no effect on mTORC1 activation by AAs, suggesting that these G proteins are also not involved. We conclude that AAs regulate ERK1/2 and mTORC1 through distinct signaling pathways. PMID:26168033

  11. MinION Analysis and Reference Consortium: Phase 1 data release and analysis

    PubMed Central

    Eccles, David A.; Zalunin, Vadim; Urban, John M.; Piazza, Paolo; Bowden, Rory J.; Paten, Benedict; Mwaigwisya, Solomon; Batty, Elizabeth M.; Simpson, Jared T.; Snutch, Terrance P.

    2015-01-01

    The advent of a miniaturized DNA sequencing device with a high-throughput contextual sequencing capability embodies the next generation of large scale sequencing tools. The MinION™ Access Programme (MAP) was initiated by Oxford Nanopore Technologies™ in April 2014, giving public access to their USB-attached miniature sequencing device. The MinION Analysis and Reference Consortium (MARC) was formed by a subset of MAP participants, with the aim of evaluating and providing standard protocols and reference data to the community. Envisaged as a multi-phased project, this study provides the global community with the Phase 1 data from MARC, where the reproducibility of the performance of the MinION was evaluated at multiple sites. Five laboratories on two continents generated data using a control strain of Escherichia coli K-12, preparing and sequencing samples according to a revised ONT protocol. Here, we provide the details of the protocol used, along with a preliminary analysis of the characteristics of typical runs including the consistency, rate, volume and quality of data produced. Further analysis of the Phase 1 data presented here, and additional experiments in Phase 2 of E. coli from MARC are already underway to identify ways to improve and enhance MinION performance. PMID:26834992

  12. MinION Analysis and Reference Consortium: Phase 1 data release and analysis.

    PubMed

    Ip, Camilla L C; Loose, Matthew; Tyson, John R; de Cesare, Mariateresa; Brown, Bonnie L; Jain, Miten; Leggett, Richard M; Eccles, David A; Zalunin, Vadim; Urban, John M; Piazza, Paolo; Bowden, Rory J; Paten, Benedict; Mwaigwisya, Solomon; Batty, Elizabeth M; Simpson, Jared T; Snutch, Terrance P; Birney, Ewan; Buck, David; Goodwin, Sara; Jansen, Hans J; O'Grady, Justin; Olsen, Hugh E

    2015-01-01

    The advent of a miniaturized DNA sequencing device with a high-throughput contextual sequencing capability embodies the next generation of large scale sequencing tools. The MinION™ Access Programme (MAP) was initiated by Oxford Nanopore Technologies™ in April 2014, giving public access to their USB-attached miniature sequencing device. The MinION Analysis and Reference Consortium (MARC) was formed by a subset of MAP participants, with the aim of evaluating and providing standard protocols and reference data to the community. Envisaged as a multi-phased project, this study provides the global community with the Phase 1 data from MARC, where the reproducibility of the performance of the MinION was evaluated at multiple sites. Five laboratories on two continents generated data using a control strain of Escherichia coli K-12, preparing and sequencing samples according to a revised ONT protocol. Here, we provide the details of the protocol used, along with a preliminary analysis of the characteristics of typical runs including the consistency, rate, volume and quality of data produced. Further analysis of the Phase 1 data presented here, and additional experiments in Phase 2 of E. coli from MARC are already underway to identify ways to improve and enhance MinION performance. PMID:26834992

  13. Novel I1-Imidazoline Agonist S43126 Augment Insulin Secretion in Min6 Cells

    PubMed Central

    Tesfai, Jerusalem; Crane, Louis; Baziard-Mouysset, Genevieve; Edwards, Lincoln P.

    2016-01-01

    The I1-imidazoline receptor is a novel drug target for hypertension and insulin resistance which are major disorders associated with Type II diabetes. In the present study, we examined the effects of a novel imidazoline agonist S43126 on calcium fluxes and insulin secretion from Min6 β-cells. We also examined the effects of S43126 on the induction of IRAS, and phosphorylation of components in the I1-imidazoline signaling pathways, namely ERK and PKB. Min6 β-cells were treated with varying doses of S43126 [10−8M to 10−5M] for various time (5–60mins). S43126 at higher dose [10−5M] stimulated insulin secretion under elevated glucose concentration compared to basal. In addition, insulin secretion and Ca2+ influx mediated by S43126 [10−5M] were decreased following co-treatment with efaroxan (I1-antagonist) and nifedipine (L-type voltage-gated Ca2+-channel blocker) at various times (5–60mins). Furthermore, S43126 at [10−5M] increased Ca2+ oscillation, [Ca2+] and 45Ca2+ uptake in a time and dose-dependent manner. Moreover, Western blot analysis of treated samples showed that S43126 caused an increased protein expression of IRAS as well as phosphorylation of both ERK1/2 and PKB in a concentration-dependent manner. We conclude that S43126 exerts its insulinotropic effect in a glucose dependent manner by a mechanism involving L-type calcium channels and imidazoline I1-receptors.

  14. Statistical properties of superflares on solar-type stars based on 1-min cadence data

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Shibayama, Takuya; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    2015-04-01

    We searched for superflares on solar-type stars using Kepler data with 1-min sampling in order to detect superflares with a short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of 1032 to 1036 erg. Some superflares show multiple peaks with the peak separation of the order of 100 to 1,000 s which is comparable to the periods of quasi-periodic pulsations in solar and stellar flares. Using these new data combined with the results from the data with 30-min sampling, we found that the occurrence frequency (dN/dE) of superflares as a function of flare energy ( E) shows the power-law distribution (dN/dE∝ E - α ) with α˜-1.5 for 1033< E<1036 erg which is consistent with the previous results. The average occurrence rate of superflares with the energy of 1033 erg which is equivalent to X100 solar flares is about once in 500 to 600 years. The upper limit of energy released by superflares is basically comparable to a fraction of the magnetic energy stored near starspots which is estimated from the photometry. We also found that the duration of superflares ( τ) increases with the flare energy ( E) as τ∝ E 0.39 ± 0.03. This can be explained if we assume the time scale of flares is determined by the Alfvén time.

  15. A Protocol to Enhance INS1E and MIN6 Functionality-The Use of Theophylline.

    PubMed

    Groot Nibbelink, Milou; Marchioli, Giulia; Moroni, Lorenzo; Karperien, Marcel; Van Apeldoorn, Aart

    2016-01-01

    In vitro research in the field of type I diabetes is frequently limited by the availability of a functional model for islets of Langerhans. This method shows that by the addition of theophylline to the glucose buffers, mouse insulinoma MIN6 and rat insulinoma INS1E pseudo-islets can serve as a model for islets of Langerhans for in vitro research. The effect of theophylline is dose- and cell line-dependent, resulting in a minimal stimulation index of five followed by a rapid return to baseline insulin secretion by reducing glucose concentrations after a first high glucose stimulation. This protocol solves issues concerning in vitro research for type I diabetes as donors and the availability of primary islets of Langerhans are limited. To avoid the limitations of using human donor material, cell lines represent a valid alternative. Many different β cell lines have been reported, but the lack of reproducible responsiveness to glucose stimulation remains a challenge. PMID:27626415

  16. The intronic minisatellite OsMin1 within a serine protease gene in the Chinese caterpillar fungus Ophiocordyceps sinensis.

    PubMed

    Zhang, Yong-Jie; Hou, Jun-Xiu; Zhang, Shu; Hausner, Georg; Liu, Xing-Zhong; Li, Wen-Jia

    2016-04-01

    Repetitive DNA sequences make up a significant portion of all genomes and may occur in intergenic, regulatory, coding, or even intronic regions. Partial sequences of a serine protease gene csp1 was previously used as a population genetic marker of the Chinese caterpillar fungus Ophiocordyceps sinensis, but its first intron region was excluded due to ambiguous alignment. Here in this study, we report the presence of a minisatellite OsMin1 within this intron, where a 20(19)-bp repeat motif is duplicated two to six times in different isolates. Fourteen intron alleles and 13 OsMin1 alleles were identified among 125 O. sinensis samples distributed broadly on the Tibetan Plateau. Two OsMin1 alleles were prevalent, corresponding to either two or five repeats of the core sequence motif. OsMin1 appears to be a single locus marker in the O. sinensis genome, but its origin is undetermined. Abundant recombination signals were detected between upstream and downstream flanking regions of OsMin1, suggesting that OsMin1 mutate by unequal crossing over. Geographic distribution, fungal phylogeny, and host insect phylogeny all significantly affected intron distribution patterns but with the greatest influence noted for fungal genotypes and the least for geography. As far as we know, OsMin1 is the first minisatellite found in O. sinensis and the second found in fungal introns. OsMin1 may be useful in designing an efficient protocol to discriminate authentic O. sinensis from counterfeits. PMID:26754819

  17. The Arabidopsis minE mutation causes new plastid and FtsZ1 localization phenotypes in the leaf epidermis

    PubMed Central

    Fujiwara, Makoto T.; Kojo, Kei H.; Kazama, Yusuke; Sasaki, Shun; Abe, Tomoko; Itoh, Ryuuichi D.

    2015-01-01

    Plastids in the leaf epidermal cells of plants are regarded as immature chloroplasts that, like mesophyll chloroplasts, undergo binary fission. While mesophyll chloroplasts have generally been used to study plastid division, recent studies have suggested the presence of tissue- or plastid type-dependent regulation of plastid division. Here, we report the detailed morphology of plastids and their stromules, and the intraplastidic localization of the chloroplast division-related protein AtFtsZ1-1, in the leaf epidermis of an Arabidopsis mutant that harbors a mutation in the chloroplast division site determinant gene AtMinE1. In atminE1, the size and shape of epidermal plastids varied widely, which contrasts with the plastid phenotype observed in atminE1 mesophyll cells. In particular, atminE1 epidermal plastids occasionally displayed grape-like morphology, a novel phenotype induced by a plastid division mutation. Observation of an atminE1 transgenic line harboring an AtMinE1 promoter::AtMinE1-yellow fluorescent protein fusion gene confirmed the expression and plastidic localization of AtMinE1 in the leaf epidermis. Further examination revealed that constriction of plastids and stromules mediated by the FtsZ1 ring contributed to the plastid pleomorphism in the atminE1 epidermis. These results illustrate that a single plastid division mutation can have dramatic consequences for epidermal plastid morphology, thereby implying that plastid division and morphogenesis are differentially regulated in epidermal and mesophyll plastids. PMID:26500667

  18. Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise

    PubMed Central

    Vendelbo, M. H.; Møller, A. B.; Treebak, J. T.; Gormsen, L. C.; Goodyear, L. J.; Wojtaszewski, J. F. P.; Jørgensen, J. O. L.; Møller, N.

    2014-01-01

    Background: phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4 mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in response to acute exercise is not fully characterized. Objective: to study AS160 and TBC1D1 phosphorylation in human skeletal muscle after aerobic exercise followed by a hyperinsulinemic euglycemic clamp. Design: eight healthy men were studied on two occasions: 1) in the resting state and 2) in the hours after a 1-h bout of ergometer cycling. A hyperinsulinemic euglycemic clamp was initiated 240 min after exercise and in a time-matched nonexercised control condition. We obtained muscle biopsies 30 min after exercise and in a time-matched nonexercised control condition (t = 30) and after 30 min of insulin stimulation (t = 270) and investigated site-specific phosphorylation of AS160 and TBC1D1. Results: phosphorylation on AS160 and TBC1D1 was increased 30 min after the exercise bout, whereas phosphorylation of the putative upstream kinases, Akt and AMPK, was unchanged compared with resting control condition. Exercise augmented insulin-stimulated phosphorylation on AS160 at Ser341 and Ser704 270 min after exercise. No additional exercise effects were observed on insulin-stimulated phosphorylation of Thr642 and Ser588 on AS160 or Ser237 and Thr596 on TBC1D1. Conclusions: AS160 and TBC1D1 phosphorylations were evident 30 min after exercise without simultaneously increased Akt and AMPK phosphorylation. Unlike TBC1D1, insulin-stimulated site-specific AS160 phosphorylation is modified by prior exercise, but these sites do not include Thr642 and Ser588. Together, these data provide new insights into phosphorylation of key regulators of glucose transport in human skeletal muscle. PMID:24876356

  19. Development and testing of 100 kW/1 min Li-ion battery systems for energy storage applications

    NASA Astrophysics Data System (ADS)

    Clark, N. H.; Doughty, D. H.

    Two 100 kW min -1 (1.67 kW h -1) Li-ion battery energy storage systems (BESS) are described. The systems include a high-power Li-ion battery and a 100 kW power conditioning system (PCS). The battery consists of 12 modules of 12 series-connected Saft Li-ion VL30P cells. The stored energy of the battery ranges from 1.67 to 14 kW h -1 and has an operating voltage window of 515-405 V (dc). Two complete systems were designed, built and successfully passed factory acceptance testing after which each was deployed in a field demonstration. The first demonstration used the system to supplement distributed microturbine generation and to provide load following capability. The system was run at its rated power level for 3 min, which exceeded the battery design goal by a factor of 3. The second demonstration used another system as a stand-alone uninterrupted power supply (UPS). The system was available (online) for 1146 h and ran for over 2 min.

  20. Transcription of TIR1-Controlled Genes Can be Regulated within 10 Min by an Auxin-Induced Process. Can TIR1 be the Receptor?

    PubMed Central

    Labusch, Corinna; Effendi, Yunus; Fulda, Martin; Scherer, Günther F. E.

    2016-01-01

    ABP1 and TIR1/AFBs are known as auxin receptors. ABP1 is linked to auxin responses several of which are faster than 10 min. TIR1 regulates auxin-induced transcription of early auxin genes also within minutes. We use transcription of such TIR1-dependent genes as indicator of TIR1 activity to show the rapid regulation of TIR1 by exogenous auxin. To this end, we used quantification of transcription of a set of fifteen early auxin-induced reporter genes at t = 10 and t = 30 min to measure this as a TIR1-dependent auxin response. We conducted this study in 22 mutants of auxin transporters (pin5, abcb1, abcb19, and aux1/lax3), protein kinases and phosphatases (ibr5, npr1, cpk3, CPK3-OX, d6pk1, d6pkl1-1, d6pkl3-2, d6pkl1-1/d6pkl2-2, and d6pkl1-1/d6pkl3-2), of fatty acid metabolism (fad2-1, fad6-1, ssi2, lacs4, lacs9, and lacs4/lacs9) and receptors (tir1, tir1/afb2, and tir1/afb3) and compared them to the wild type. After 10 min auxin application, in 18 out of 22 mutants mis-regulated expression of at least one reporter was found, and in 15 mutants transcription of two-to-three out of five selected auxin reporter genes was mis-regulated. After 30 min of auxin application to mutant plants, mis-regulation of reporter genes ranged from one to 13 out of 15 tested reporter genes. Those genes chosen as mutants were themselves not regulated in their expression by auxin for at least 1 h, excluding an influence of TIR1/AFBs on their transcription. The expression of TIR1/AFB genes was also not modulated by auxin for up to 3 h. Together, this excludes a feedback or feedforward of these mutant genes/proteins on TIR1/AFBs output of transcription in this auxin-induced response. However, an auxin-induced response needed an as yet unknown auxin receptor. We suggest that the auxin receptor necessary for the fast auxin-induced transcription modulation could be, instead, ABP1. The alternative hypothesis would be that auxin-induced expression of a protein, initiated by TIR1/AFBs receptors

  1. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion

    PubMed Central

    Cao, Zhijuan; Balasubramanian, Adithya

    2013-01-01

    Traditional methods of therapeutic hypothermia show promise for neuroprotection against cerebral ischemia-reperfusion (I/R), however, with limitations. We examined effectiveness and specificity of pharmacological hypothermia (PH) by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (Tcore) was measured after subcutaneous infusion of TRPV1 agonist dihydrocapsaicin (DHC) in conscious C57BL/6 WT and TRPV1 knockout (KO) mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (1 h ischemia + 24 h reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (>8 h) was initiated 90 min after start of reperfusion by DHC infusion (osmotic pump). Neurofunction (behavioral testing) and infarct volume (TTC staining) were measured at 24 h. DHC (1.25 mg/kg) produced a stable drop in Tcore (33°C) in naive and I/R mouse models but not in TRPV1 KO mice. DHC (1.25 mg/kg) had no measurable effect on HR and cerebral perfusion but produced a slight transient drop in MAP (<6 mmHg). In stroke mice, DHC infusion produced hypothermia, decreased infarct volume by 87%, and improved neurofunctional score. The hypothermic and neuroprotective effects of DHC were absent in TRPV1 KO mice or mice maintained normothermic with heat support. PH via TRPV1 agonist appears to be a well-tolerated and effective method for promoting mild hypothermia in the conscious mouse. Furthermore, TRPV1 agonism produces effective hypothermia in I/R mice and significantly improves outcome when initiated 90 min after start of reperfusion. PMID:24305062

  2. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating.

    PubMed

    Lewis, Anthony; McCrossan, Zoe A; Abbott, Geoffrey W

    2004-02-27

    High frequency firing in mammalian neurons requires ultra-rapid delayed rectifier potassium currents generated by homomeric or heteromeric assemblies of Kv3.1 and Kv3.2 potassium channel alpha subunits. Kv3.1 alpha subunits can also form slower activating channels by coassembling with MinK-related peptide 2 (MiRP2), a single transmembrane domain potassium channel ancillary subunit. Here, using channel subunits cloned from rat and expressed in Chinese hamster ovary cells, we show that modulation by MinK, MiRP1, and MiRP2 is a general mechanism for slowing of Kv3.1 and Kv3.2 channel activation and deactivation and acceleration of inactivation, creating a functionally diverse range of channel complexes. MiRP1 also negatively shifts the voltage dependence of Kv3.1 and Kv3.2 channel activation. Furthermore, MinK, MiRP1, and MiRP2 each form channels with Kv3.1-Kv3.2 heteromers that are kinetically distinct from one another and from MiRP/homomeric Kv3 channels. The findings illustrate a mechanism for dynamic expansion of the functional repertoire of Kv3.1 and Kv3.2 potassium currents and suggest roles for these alpha subunits outside the scope of sustained rapid neuronal firing. PMID:14679187

  3. Joint min-max distribution and Edwards-Anderson's order parameter of the circular 1/f-noise model

    NASA Astrophysics Data System (ADS)

    Cao, Xiangyu; Le Doussal, Pierre

    2016-05-01

    We calculate the joint min-max distribution and the Edwards-Anderson's order parameter for the circular model of 1/f-noise. Both quantities, as well as generalisations, are obtained exactly by combining the freezing-duality conjecture and Jack-polynomial techniques. Numerical checks come with significantly improved control of finite-size effects in the glassy phase, and the results convincingly validate the freezing-duality conjecture. Application to diffusive dynamics is discussed. We also provide a formula for the pre-factor ratio of the joint/marginal Carpentier-Le Doussal tail for minimum/maximum which applies to any logarithmic random energy model.

  4. Characterization of the MUC1.Tg/MIN Transgenic Mouse as a Model for Studying Antigen-Specific Immunotherapy of Adenomas

    PubMed Central

    Akporiaye, Emmanuel T.; Bradley-Dunlop, Deborah; Gendler, Sandra J.; Mukherjee, Pinku; Madsen, Cathy S.; Hahn, Tobias; Besselsen, David G.; Dial, Sharon M.; Cui, Haiyan; Trevor, Katrina

    2007-01-01

    A bigenic MUC1.Tg/MIN mouse model was developed by crossing Apc/MIN/+ (MIN) mice with human MUC1 transgenic mice to evaluate MUC1 antigen-specific immunotherapy of intestinal adenomas. The MUC1.Tg/MIN mice developed adenomas at a rate comparable to that of MIN mice and had similar levels of serum MUC1 antigen. A MUC1-based vaccine consisting of MHC class I-restricted MUC1 peptides, a MHC class II-restricted pan-helper peptide, unmethylated CpG oligodeoxynucleotide and GM-CSF caused flattening of adenomas and significantly reduced the number of large adenomas. Immunization was successful in generating a MUC1-directed immune response evidenced by increased MUC1 peptide-specific anti-tumor cytotoxicity and IFN-γ secretion by lymphocytes. PMID:17707958

  5. Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling

    PubMed Central

    Chen, Wen-Jia; Wang, Lin-Xi; Wang, Yan-Ping; Chen, Zhou; Liu, Xiao-Ying; Liu, Xiao-Hong; Liu, Li-Bin

    2012-01-01

    Objectives. This study aimed to explore the effect of exendin-4 on t-BHP-induced apoptosis in pancreatic β cells and the mechanism of action. Methods. Murine MIN6 pancreatic β cells were treated with exendin-4 in the presence or absence of tert-butyl hydroperoxide (t-BHP). Cell survival was assessed by MTT staining. The percentage of apoptotic cells was determined by fluorescence microscopy analysis after Hoechst/PI staining and flow cytometric assay after Annexin V-FITC/PI staining. The activity of caspase-3 was determined using a caspase-3 activity kit. Expression of P-IRE1α, IRE1α, C-Jun N-terminal kinase (JNK), P-JNK, C-JUN, and P-C-JUN was detected by western blotting. Results. Exendin-4 was found to inhibit t-BHP-induced apoptosis in pancreatic β-cells by downregulating caspase-3 activity. Exendin-4 also inhibited the endoplasmic reticulum transmembrane protein IRE1, the apoptosis-related signaling molecule JNK, and c-Jun activation. Conclusions. Our findings suggest that exendin-4 ultimately reduces t-BHP-induced β-cell apoptosis. IRE1-JNK-c-Jun signaling is involved in the exendin-4-mediated modulation of β-cell apoptosis. PMID:22518128

  6. Statistical properties of superflares on solar-type stars based on the Kepler 1-min cadence data

    NASA Astrophysics Data System (ADS)

    Maehara, Hiroyuki; Shibayama, Takuya; Notsu, Yuta; Notsu, Shota; Honda, Satoshi; Nogami, Daisaku; Shibata, Kazunari

    2015-08-01

    We searched for superflares on solar-type stars using the Kepler short-cadence (1-min sampling) data in order to detect superflares with short duration. We found 187 superflares on 23 solar-type stars whose bolometric energy ranges from the order of 1032 erg to 1036 erg. Some superflares show multiple peaks with the peak separation of the order of 100-1000 seconds which is comparable to the periods of quasi-periodic pulsations in solar and stellar flares. Using these new data combined with the results from the data with 30 min sampling, we found the occurrence frequency (dN/dE) of superflares as a function of flare energy (E) shows the power-law distribution (dN/dE ∝ E-α) with α=1.5 for 1033

  7. Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1+minK channels

    PubMed Central

    Gómez, Ricardo; Núñez, Lucía; Caballero, Ricardo; Vaquero, Miguel; Tamargo, Juan; Delpón, Eva

    2005-01-01

    Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac action potential duration and decrease the Kv11.1 (HERG) current. We examined the effects of SP and CA on cardiac hKv1.5, Kv4.3 and Kv7.1+minK channels that generate the human IKur, Ito1 and IKs, which contribute to the control of human cardiac action potential duration. hKv1.5 currents were recorded in stably transfected mouse fibroblasts and Kv4.3 and Kv7.1+minK in transiently transfected Chinese hamster ovary cells using the whole-cell patch clamp. SP (1 μM) and CA (1 nM) inhibited hKv1.5 currents by 23.2±3.2 and 18.9±2.7%, respectively, shifted the midpoint of the activation curve to more negative potentials and delayed the time course of tail deactivation. SP (1 μM) and CA (1 nM) inhibited the total charge crossing the membrane through Kv4.3 channels at +50 mV by 27.1±6.4 and 27.4±5.7%, respectively, and accelerated the time course of current decay. CA, but not SP, shifted the inactivation curve to more hyperpolarised potentials (Vh−37.0±1.8 vs −40.8±1.6 mV, n=10, P<0.05). SP (10 μM) and CA (1 nM) also inhibited Kv7.1+minK currents by 38.6±2.3 and 22.1±1.4%, respectively, without modifying the voltage dependence of channel activation. SP, but not CA, slowed the time course of tail current decay. CA (1 nM) inhibited the IKur (29.2±5.5%) and the Ito1 (16.1±3.9%) recorded in mouse ventricular myocytes and the IK (21.8±6.9%) recorded in guinea-pig ventricular myocytes. A mathematical model of human atrial action potentials demonstrated that K+ blocking effects of CA resulted in a lengthening of action potential duration, both in normal and atrial fibrillation simulated conditions. The results demonstrated that both SP and CA directly block hKv1.5, Kv4.3 and Kv7.1+minK channels, CA being more potent for these effects. Since peak free plasma concentrations of CA ranged between 3 and 16 nM, these results indicated that blockade of these human

  8. Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.

    PubMed Central

    Fujita, N; Mori, H; Yura, T; Ishihama, A

    1994-01-01

    The complete sequence analysis of the E. coli genome was initiated as a collaborative study in Japan. Following the initial analysis of the 0-2.4 min region (Yura, T. et al. (1992) Nucleic Acids Res. 20, 3305-3308), a contiguous sequence of 82,727 bp corresponding to the 2.4-4.1 min region (110,917-193,643 bp as counted from 0 min) was determined. The resulting sequence was found to contain at least 33 known genes and 24 putative genes predicted from protein sequence homology. PMID:8202364

  9. Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in the APC(Min/+) mouse using optical colonography.

    PubMed

    Roney, Celeste A; Xu, Biying; Xie, Jianwu; Yuan, Shuai; Wierwille, Jeremiah; Chen, Chao-Wei; Chen, Yu; Griffiths, Gary L; Summers, Ronald M

    2011-08-01

    Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabricated to locate and image adenomatous polyps in APC(Min/+) mice. The biomarker α-L-fucose covalently joins the liposomal conjugated lectin Ulexeuropaeus agglutinin (UEA-1), via glycosidic linkage to the polyp mucin layer. Multispectral optical imaging (MSI) corroborated a global perspective of specific binding (rhodamine B 532 nm emission, 590-620 nm excitation) of targeted Rh-I-UEA-1 polymerized liposomes to polyps with 1.4-fold labeling efficiency. High-resolution coregistered optical coherence tomography (OCT) and fluorescence molecular imaging (FMI) reveal the spatial correlation of contrast distribution and tissue morphology. Freshly excised APC(Min) bowels were incubated with targeted liposomes (UEA-1 lectin), control liposomes (no lectin), or iohexol (Omnipaque) and imaged by the three techniques. Computed tomographic quantitative analyses did not confirm that targeted liposomes more strongly bound polyps than nontargeted liposomes or iohexol (Omnipaque) alone. OCT, with anatomic depth capabilities, along with the coregistered FMI, substantiated Rh-I-UEA-1 liposome binding along the mucinous polyp surface. UEA-1 lectin denotes α-l-fucose biomarker carbohydrate expression at the mucin glycoprotein layer; Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in APC(Min) mice. PMID:21521550

  10. Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1

    PubMed Central

    Suzuki, Kengo; Sato, Yoshifumi; Kai, Shinichi; Nishi, Kenichiro; Adachi, Takehiko; Matsuo, Yoshiyuki

    2015-01-01

    Proper glycemic control is one of the most important goals in perioperative patient management. Insulin secretion from pancreatic β-cells in response to an increased blood glucose concentration plays the most critical role in glycemic control. Several animal and human studies have indicated that volatile anesthetics impair glucose-stimulated insulin secretion (GSIS). A convincing GSIS model has been established, in which the activity of ATP-dependent potassium channels (KATP) under the control of intracellular ATP plays a critical role. We previously reported that pimonidazole adduct formation and stabilization of hypoxia-inducible factor-1α (HIF-1α) were detected in response to glucose stimulation and that MIN6 cells overexpressing HIF-1α were resistant to glucose-induced hypoxia. Genetic ablation of HIF-1α or HIF-1β significantly inhibited GSIS in mice. Moreover, we previously reported that volatile anesthetics suppressed hypoxia-induced HIF activation in vitro and in vivo.To examine the direct effect of volatile anesthetics on GSIS, we used the MIN6 cell line, derived from mouse pancreatic β-cells. We performed a series of experiments to examine the effects of volatile anesthetics (sevoflurane and isoflurane) on GSIS and demonstrated that these compounds inhibited the glucose-induced ATP increase, which is dependent on intracellular hypoxia-induced HIF-1 activity, and suppressed GSIS at a clinically relevant dose in these cells. PMID:26713247

  11. A sample introduction system for an inductively coupled plasma operating on an argon carrier gas flow of 0.1 l/min

    NASA Astrophysics Data System (ADS)

    Ripson, P. A. M.; de Galan, L.

    A sample introduction system is described for use with a water-cooled ICP torch described previously [ Anal. Chem.51, 2378 (1979)]. It consists of a narrow bore (100 μm) stainless steel Babington nebulizer operating on 0.05 to 0.2 l/min argon inserted into a small (10 ml) nebulizer chamber. The solvent is force-fed continuously by gas pressure or with a peristaltic pump. Liquid samples can be supplied continuously or in discrete quantities using a sample loop between the pump and the nebulizer. In the latter case only 25 s are required for sample change. The nebulization efficiency for water and organic solvents is comparable to that of conventional pneumatic nebulizers operating on 1 l/min argon.

  12. Reduction of Argon Consumption to Less than 2 L min(-1) by Gas Recycling in Inductively Coupled Plasma Optical Emission Spectrometry.

    PubMed

    Tirk, Paul; Wolfgang, Matthias; Wiltsche, Helmar

    2016-07-19

    An innovative interface between the torch and the entrance optics for inductively coupled plasma optical emission spectrometry (ICP-OES) is proposed. This system is capable of collecting all argon which was initially supplied to the torch, cooling and cleaning it and feeding most of the argon back to the outer gas port of the torch. Thereby, the total argon consumption could be reduced from 14 to 1.4 L min(-1) using a standard torch and without restricting the rf power. The excitation- and rotational temperature of the plasma were identical when comparing the traditional setup with the enclosed plasma interface. However, the limits of detection (LOD) and limits of quantification (LOQ) of 27 elements investigated were degraded about 5-fold, though this fact can be expected to stem from a change of the observed zone in the plasma caused by the slight overpressure of 2000 Pa within the interface. Though the enclosed plasma interface was located close to the load coil, the rf power coupled to the interface was well below 1 W and no rf arcing was observed for two different rf generator designs. PMID:27306111

  13. Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases.

    PubMed

    Svendsen, Camilla; Meinl, Walter; Glatt, Hansruedi; Alexander, Jan; Knutsen, Helle K; Hjertholm, Hege; Rasmussen, Tone; Husøy, Trine

    2012-12-01

    Humans express sulfotransferases (SULTs) of the SULT1A subfamily in many tissues, whilst the single SULT1A gene present in rodents is mainly expressed in liver. The food processing contaminants, 5-hydroxymethylfurfural (HMF) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), are bioactivated by human SULT1A1 and SULT1A2. FVB multiple intestinal neoplasia (Min) mice, which spontaneously develop tumors and flat aberrant crypt foci (ACF) in intestine, were crossed with transgenic FVB mice expressing human SULT1A1 and 1A2 (hSULT) in several tissues, giving rise to wild-type and Min mice with and without hSULT. One-week-old Min mice with or without hSULT were given HMF (375 or 750 mg/kg bw) or saline by gavage three times a week for 11 wk. In another experiment, the F1 generation received subcutaneous injections of 50 mg/kg bw PhIP or saline 1 wk before birth, and 1, 2, and 3 wk after birth. HMF did not affect the formation of tumors, but may have induced some flat ACF (incidence 15-20%) in Min mice with and without hSULT. No control mouse developed any flat ACF. With the limitation that these putative effects were weak, they were unaffected by hSULT expression. The carcinogenic effect of PhIP increased in the presence of hSULT, with a significant increase in both incidence (31-80%) and number of colonic tumors (0.4-1.3 per animal). Thus, intestinal expression of human SULT1A1 and 1A2 might increase the susceptibility to compounds bioactivated via this pathway implying that humans might be more susceptible than conventional rodent models. PMID:22006426

  14. Spironolactone use and higher hospital readmission for Medicare beneficiaries with heart failure, left ventricular ejection fraction <45%, and estimated glomerular filtration rate <45 ml/min/1.73 m(2.).

    PubMed

    Inampudi, Chakradhari; Parvataneni, Sridivya; Morgan, Charity J; Deedwania, Prakash; Fonarow, Gregg C; Sanders, Paul W; Prabhu, Sumanth D; Butler, Javed; Forman, Daniel E; Aronow, Wilbert S; Allman, Richard M; Ahmed, Ali

    2014-07-01

    Although randomized controlled trials have demonstrated benefits of aldosterone antagonists for patients with heart failure and reduced ejection fraction (HFrEF), they excluded patients with serum creatinine >2.5 mg/dl, and their use is contraindicated in those with advanced chronic kidney disease (CKD). In the present analysis, we examined the association of spironolactone use with readmission in hospitalized Medicare beneficiaries with HFrEF and advanced CKD. Of the 1,140 patients with HFrEF (EF <45%) and advanced CKD (estimated glomerular filtration rate [eGFR] <45 ml/min/1.73 m(2)), 207 received discharge prescriptions for spironolactone. Using propensity scores (PSs) for the receipt of discharge prescriptions for spironolactone, we estimated PS-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for spironolactone-associated outcomes. Patients (mean age 76 years, 49% women, 25% African-American) had mean EF 28%, mean eGFR 31 ml/min/1.73 m(2), and mean potassium 4.5 mEq/L. Spironolactone use had significant PS-adjusted association with higher risk of 30-day (HR 1.41, 95% CI 1.04 to 1.90) and 1-year (HR 1.36, 95% CI 1.13 to 1.63) all-cause readmissions. The risk of 1-year all-cause readmission was higher among 106 patients with eGFR <15 ml/min/1.73 m(2) (HR 4.75, 95% CI 1.84 to 12.28) than among those with eGFR 15 to 45 ml/min/1.73 m(2) (HR 1.34, 95% CI 1.11 to 1.61, p for interaction 0.003). Spironolactone use had no association with HF readmission and all-cause mortality. In conclusion, among hospitalized patients with HFrEF and advanced CKD, spironolactone use was associated with higher all-cause readmission but had no association with all-cause mortality or HF readmission. PMID:24846806

  15. A postoperative 1-Year eGFR of More Than 45 ml/min May be the Cutoff Level for a Favorable Long-Term Prognosis in Renal Transplant Patients.

    PubMed

    Baek, Chung Hee; Kim, Hyosang; Yang, Won Seok; Han, Duck Jong; Park, Su-Kil

    2016-01-01

    BACKGROUND One-year renal function after kidney transplantation (KT) classified by the Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease (CKD) staging has been reported to be associated with graft survival. However, the outcomes of KT are improving. Therefore, the distribution and prognostic value of 1-year estimated glomerular filtration rate (eGFR) in recently performed transplants were re-evaluated in this study. MATERIAL AND METHODS We reviewed all patients who received KT between 2008 and 2011 at our institution, and followed them until June 2015. The distribution of 1-year eGFR, graft survival according to CKD staging, the cutoff level for a favorable prognosis, and the occurrence of rejection and infection were analyzed. RESULTS A total of 758 patients were included in this study. Unlike previous studies, most patients (56.2%) were in the CKD stage 2 (eGFR 60-89) rather than stage 3 (eGFR 30-59). In addition, the CKD stage 3a (eGFR 45-59) group showed better graft survival than the CKD stage 3b (eGFR 30-44) group. However, CKD stage 2 and CKD stage 3a groups did not show significant differences in graft survival. Patients with postoperative 1-year eGFR ≥45 ml/min showed a more favorable outcome compared with those with postoperative 1-year eGFR <45 ml/min. One-year eGFR<45 ml/min, acute cellular rejection, antibody-mediated rejection, and CMV infection after 1 year were adjusted risk factors for graft failure. CONCLUSIONS A 1-year eGFR ≥45 ml/min may be the appropriate cutoff level for predicting favorable outcomes in KT. In addition, KDIGO CKD staging may no longer be useful in recently performed KT. PMID:27418011

  16. The Thermal Breadth of Nylanderia fulva (Hymenoptera: Formicidae) Is Narrower Than That of Solenopsis invicta at Three Thermal Ramping Rates: 1.0, 0.12, and 0.06°C min-1.

    PubMed

    Bentley, M T; Hahn, D A; Oi, F M

    2016-08-01

    Determining the upper (CTmax) and lower (CTmin) critical thermal limits of invasive ants provides insight into how temperature could shape their distribution, seasonality, and daily activity. Understanding the potential distribution of invasive ants is imperative to improving quarantine and management efforts. Nylanderia fulva (Mayr) (tawny crazy ant) and Solenopsis invicta (Buren) (red imported fire ant) are invasive ants that are established throughout the southeastern United States. Recent studies have found that body size and thermal ramping rate can affect the estimation of critical thermal limits. However, the effects of both variables and their interactions on the thermal limits of N. fulva and S. invicta have not previously been described. Thus, we evaluated the impacts of body size and ramping rate on the critical thermal limits of N. fulva and S. invicta Overall, N. fulva had a narrower thermal breadth than S. invicta (Nf CTmin = 7.3°C and Nf CTmax = 41.3°C vs. Si CTmin = 4.1°C and Si CTmax = 45.3°C). For both species, slower ramping rates resulted in lower CTmax values and ants with smaller head capsules had a narrower thermal breadth than ants with larger head capsules. These data improve our understanding of the critical thermal limits of both species and could be useful for developing predictive models that estimate the future spread of these invasive ants in nonnative ranges. PMID:27252409

  17. Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2

    PubMed Central

    Nagata, Takanobu; Hirakawa, Akihiro; Katsuno, Takayuki; Yasuda, Yoshinari; Matsuo, Seiichi; Tsuboi, Naotake; Maruyama, Shoichi

    2016-01-01

    Background Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce. Methods We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion. Outcomes were the composite of a 30% decline in eGFR or death. Multivariate cox regression analysis was used to investigate the association between urinary sodium and potassium excretion and outcomes. Results With a mean follow up period of 5.47 years, 130 patients reached the outcomes (30% decline in eGFR: 124, death: 6). Mean (SD) eGFR and 24h urinary sodium and potassium excretion at baseline were 78.6 (19.5) ml/min/1.73m2, 4.50 (1.64) g/day, and 2.14 (0.77) g/day. Compared with sodium excretion < 3.0 g/day, no significant change in risk of outcomes was observed with increased increments of 1.0 g/day. Compared with potassium excretion of < 1.5 g/day, 2.0–2.5 g/day, and 2.5–3.0 g/day were significantly associated with a lower risk of outcomes (hazard ratio [HR], 0.49 and 0.44; 95% confidence interval [CI], 0.28 to 0.84 and 0.22 to 0.87). Conclusions 24h urinary sodium excretion was not significantly associated with a risk of 30% decline in eGFR or death in patients with diabetes. However, an increased risk of 30% decline in eGFR or death was significantly associated with 24h urinary potassium excretion < 1.5 g/day than with 2.0–2.5 g/day and 2.5–3.0 g/day. PMID:27136292

  18. 1,1,1-Trichloroethane

    Integrated Risk Information System (IRIS)

    1,1,1 - Trichloroethane ; CASRN 71 - 55 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  19. MI1AENG1

    Atmospheric Science Data Center

    2014-09-03

    MI1AENG1 MISR Level 1A Engineering Data File Type 1: Reformatted Annotated Level 1A product for the camera engineering data, which represents indicators of sampled measurements. ... Status Production Report Read Software Files :  Data Product Specification Versioning ...

  20. SSCA1-K1

    2015-11-06

    SSCA1-K1 is a parallel implementation of kernel 1 of the SSCA1 benchmark suite released by the DARPA HPCS program. This kernel is able to run in parallel on a distributed shared memory system at extreme scales using OpenSHMEM.

  1. 1,1-Difluoroethane

    Integrated Risk Information System (IRIS)

    1,1 - Difluoroethane ; CASRN 75 - 37 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogen

  2. 1,1-Dichloroethane

    Integrated Risk Information System (IRIS)

    1,1 - Dichloroethane ; CASRN 75 - 34 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogen

  3. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  4. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  5. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  6. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  7. 1 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Definitions. 1.1 Section 1.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL DEFINITIONS § 1.1 Definitions. As used in this chapter, unless the context requires otherwise— Administrative Committee means the Administrative Committee of...

  8. Thoughts on Why (-1)(-1) = +1

    ERIC Educational Resources Information Center

    Rapke, Tina

    2008-01-01

    This article considers why (-1)(-1) = +1 and how and why a teacher might go about explaining this concept to high school students without using pseudoreasoning. Furthermore, it provides a precise explanation, through the use of the distributive property, as to why (-1)(-1) = +1. (Contains 1 figure.)

  9. Hawking's A Briefer History of Time's No-God-Universe disproven by primordial ^218Po halos embedded in granite rocks, which proves their rapid creation due to ^218Po's 3 min t1/2, something only the God of Genesis could have done

    NASA Astrophysics Data System (ADS)

    Gentry, Robert

    2011-04-01

    Quotes from my Science (184, 62, 1974) report, Radiohalos in Radiochronological and Cosmological Perspective, show why primordial polonium halos earlier commanded attention for creation," It is also apparent that Po halos do pose contradictions to currently held views of Earth history" "For example, there is first the problem of how isotopic separation of several Po isotopes [or their β-decay precursors could have occurred naturally. Second, a straightforward explanation of ^218Po halos implies that the 1-μm radiocenters of very dark halos of this type initially contained as many as 5 x 10^9 atoms (a concentration of more than 50 percent) of the isotope ^218Po (half-life, 3 minutes), a problem that almost defies reason. A further necessary consequence, that such Po halos could have formed only if the host rocks underwent a rapid crystallization, renders exceedingly difficult, in my estimation, the prospect of explaining these halos by physical laws as presently understood." In 1977 E. P. Wigner, G. N. Flerov (Dubna), Ed Anders, E. Segre, F. Dyson, and John Wheeler all commented on these results (see alphacosmos.net). Also, ^14N detection in dwarf radiohalos may be of cosmological significance in implying a superheavy element origin from ^14C emission.

  10. 1-Chloro-1,1-difluoroethane

    Integrated Risk Information System (IRIS)

    1 - Chloro - 1,1 - difluoroethane ; CASRN 75 - 68 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for

  11. 1,1,1,2-Tetrachloroethane

    Integrated Risk Information System (IRIS)

    1,1,1,2 - Tetrachloroethane ; CASRN 630 - 20 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonca

  12. 1,1,1,2-Tetrafluoroethane

    Integrated Risk Information System (IRIS)

    1,1,1,2 - Tetrafluoroethane ; CASRN 811 - 97 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonca

  13. Transient Pressure Test Article (TPTA) 1.1 and 1.1A, volume 1

    NASA Technical Reports Server (NTRS)

    Rebells, Clarence A.

    1988-01-01

    This final test report presents the results obtained during the static hot firing and cold-gas high Q tests of the first Transient Pressure Test Article (TPTA) 1.1. The TPTA consisted of field test joints A and B, which were the original RSRM J-insulation configuration, with a metal capture feature. It also consisted of a flight configuration nozzle-to-case test joint (Joint D) with shorter vent slots. Fluorocarbon O-rings were used in all the test joints. The purpose of the TPTA tests is to evaluate and characterize the RSMR field and nozzle-to-case joints under the influence of ignition and strut loads during liftoff anf high Q. All objectives of the cold-gas high Q (TPTA 1.1A) test were met and all measurements were close to predicted values. During the static hot-firing test (TPTA 1.1), the motor was inadvertently plugged by the quench injector plug, making it a more severe test, although no strut loads were applied. The motor was depressurized after approximately 11 min using an auxiliary system, and no anomalies were noted. In the static hot-firing test, pressure was incident on the insulation and the test joint gaps were within the predicted range. During the static hot-firing test, no strut loads were applied because the loading system malfunctioned. For this test, all measurements were within range of similar tests performed without strut loads.

  14. 1,1-Dichloroethylene (1,1-DCE)

    Integrated Risk Information System (IRIS)

    1,1 - Dichloroethylene ( 1,1 - DCE ) ; CASRN 75 - 35 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments f

  15. CMT1

    MedlinePlus

    ... 1 is the most common subtype of CMT, accounting for roughly two-thirds of all cases. CMT1 ... CMT Signs and Symptoms Diagnosis Causes/Inheritance Medical Management Research Living With Charcot-Marie-Tooth Disease (CMT) ...

  16. Heteroepitaxy of CdTe(1 1 1)B on Si(1 1 1) : As

    NASA Astrophysics Data System (ADS)

    Schick, H.; Bensing, F.; Hilpert, U.; Richter, U.; Hansen, L.; Wagner, J.; Wagner, V.; Geurts, J.; Waag, A.; Landwehr, G.

    2000-06-01

    In order to improve the structural quality of CdTe/Si composite substrates, we have investigated the MBE growth mechanisms of CdTe(1 1 1) onto planar and vicinal arsenic-passivated Si(1 1 1) surfaces. The films were characterized by in situ RHEED, X-ray diffraction, Raman spectroscopy, photoluminescence, secondary electron microscopy, transmission electron microscopy and atomic force microscopy. Rocking curves had peaks narrower than 100 arcsec at a layer thickness of only 1-2 μm. BeTe buffer layers did not show a dominant effect, whereas the twin content decreased drastically when misoriented substrates were used. Efficient twin suppression can be obtained by realizing an interface step alignment between substrate and epitaxial CdTe film.

  17. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  18. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  19. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  20. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  1. 26 CFR 1.1-1 - Income tax on individuals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Income tax on individuals. 1.1-1 Section 1.1-1... and Surtaxes § 1.1-1 Income tax on individuals. (a) General rule. (1) Section 1 of the Code imposes an... taxable years beginning before January 1, 1970) see section 3. The tax imposed is upon taxable......

  2. Neurofibromatosis-1

    MedlinePlus

    ... family who have the same NF1 gene change. "Coffee-with-milk" ( cafe-au-lait ) spots are the ... Call your health care provider if: You notice coffee-with-milk colored spots on your child's skin ...

  3. GTM-1

    2007-02-08

    GTM-1 was developed for the assessment of radionuclide transport by the ground-water through geoligic formations whose properties can change along the pathway. The program was developed for specific use within Probabilistic System Assessment (PSA) Monte Carlo codes.

  4. 1,1,2-Trichloropropane

    Integrated Risk Information System (IRIS)

    1,1,2 - Trichloropropane ; CASRN 598 - 77 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarci

  5. 1,1,2-Trichloroethane

    Integrated Risk Information System (IRIS)

    1,1,2 - Trichloroethane ; CASRN 79 - 00 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  6. 1/N

    SciTech Connect

    Coleman, S.

    1980-03-01

    There exist families of field theories with symmetry group SO(N) (or SU(N)) that become simpler as N becomes larger. More precisely, the solutions to these theories possess an expansion in powers of 1/N. This expansion is the subject of these lectures. The 1/N expansion can be used to analyze model field theories. The 1/N expansion is developed for phi/sup 4/ theory and applied to two two-dimensional models with similar combinatoric structures, the Gross-Neveu model and the CP/sup N-1/ model. These models display (in the leading 1/N approximation) such interesting phenomena as asymptotic freedom, dynamical symmetry breaking, dimensional transmutation, and non-perturbative confinement. It is possible that the 1/N expansion, with N the number of colors, might fruitfully be applied to quantum chromodynamics. Unfortunately, it is not possible to make a decisive test of the approximation, because no one knows how to compute even the first term in the expansion in closed form. However, it is possible to argue that this first term, whatever its detailed form, has many properties that are also shared by the real world, and which are otherwise underived from field theory. These include the saturation of scattering amplitudes by an infinite number of narrow resonances, the essential feature of dual-resonance models. (RWR)

  7. TRPC1.

    PubMed

    Nesin, Vasyl; Tsiokas, Leonidas

    2014-01-01

    The TRPC1 ion channel was the first mammalian TRP channel to be cloned. In humans, it is encoded by the TRPC1 gene located in chromosome 3. The protein is predicted to consist of six transmembrane segments with the N- and C-termini located in the cytoplasm. The extracellular loop connecting transmembrane segments 5 and 6 participates in the formation of the ionic pore region. Inside the cell, TRPC1 is present in the endoplasmic reticulum, plasma membrane, intracellular vesicles, and primary cilium, an antenna-like sensory organelle functioning as a signaling platform. In human and rodent tissues, it shows an almost ubiquitous expression. TRPC1 interacts with a diverse group of proteins including ion channel subunits, receptors, and cytosolic proteins to mediate its effect on Ca(2+) signaling. It primarily functions as a cation nonselective channel within pathways controlling Ca(2+) entry in response to cell surface receptor activation. Through these pathways, it affects basic cell functions, such as proliferation and survival, differentiation, secretion, and cell migration, as well as cell type-specific functions such as chemotropic turning of neuronal growth cones and myoblast fusion. The biological role of TRPC1 has been studied in genetically engineered mice where the Trpc1 gene has been experimentally ablated. Although these mice live to adulthood, they show defects in several organs and tissues, such as the cardiovascular, central nervous, skeletal and muscular, and immune systems. Genetic and functional studies have implicated TRPC1 in diabetic nephropathy, Parkinson's disease, Huntington's disease, Duchenne muscular dystrophy, cancer, seizures, and Darier-White skin disease. PMID:24756701

  8. Pentacene on Au(111), Ag(111) and Cu(111): From physisorption to chemisorption

    NASA Astrophysics Data System (ADS)

    Lu, Meng-Chao; Wang, Rong-Bin; Yang, Ao; Duhm, Steffen

    2016-03-01

    We measured the electronic and the molecular surface structure of pentacene deposited on the (111)-surfaces of coinage metals by means of ultraviolet photoelectron spectroscopy (UPS) and low-energy electron diffraction (LEED). Pentacene is almost flat-lying in monolayers on all three substrates and highly ordered on Au(111) and on Cu(111). On Ag(111), however, weak chemisorption leads to almost disordered monolayers, both, at room temperature and at 78 K. On Cu(111) pentacene is strongly chemisorbed and the lowest unoccupied molecular orbital becomes observable in UPS by a charge transfer from the substrate. On Ag(111) and Cu(111) multilayers adopt a tilted orientation and a high degree of crystallinity. On Au(111), most likely, also in multilayers the molecular short and long axes are parallel to the substrate, leading to a distinctively different electronic structure than on Ag(111) and Cu(111). Overall, it could be demonstrated that the substrate not only determines the geometric and electronic characteristics of molecular monolayer films but also plays a crucial role for multilayer film growth.

  9. Pentacene on Au(111), Ag(111) and Cu(111): From physisorption to chemisorption.

    PubMed

    Lu, Meng-Chao; Wang, Rong-Bin; Yang, Ao; Duhm, Steffen

    2016-03-01

    We measured the electronic and the molecular surface structure of pentacene deposited on the (111)-surfaces of coinage metals by means of ultraviolet photoelectron spectroscopy (UPS) and low-energy electron diffraction (LEED). Pentacene is almost flat-lying in monolayers on all three substrates and highly ordered on Au(111) and on Cu(111). On Ag(111), however, weak chemisorption leads to almost disordered monolayers, both, at room temperature and at 78 K. On Cu(111) pentacene is strongly chemisorbed and the lowest unoccupied molecular orbital becomes observable in UPS by a charge transfer from the substrate. On Ag(111) and Cu(111) multilayers adopt a tilted orientation and a high degree of crystallinity. On Au(111), most likely, also in multilayers the molecular short and long axes are parallel to the substrate, leading to a distinctively different electronic structure than on Ag(111) and Cu(111). Overall, it could be demonstrated that the substrate not only determines the geometric and electronic characteristics of molecular monolayer films but also plays a crucial role for multilayer film growth. PMID:26870881

  10. Mystery #1

    Atmospheric Science Data Center

    2013-04-22

    ... is approximately 380 kilometers wide. Choose any reference material you like and see if you can answer these questions: 1.   This ... NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Science Mission Directorate, Washington, D.C. The Terra spacecraft is managed ...

  11. 1-Chlorobutane

    Integrated Risk Information System (IRIS)

    1 - Chlorobutane ; CASRN 109 - 69 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic

  12. Dynamics Explorer-1 (DE-1)

    NASA Technical Reports Server (NTRS)

    Gordon, F.; Pashby, P.

    1991-01-01

    The Dynamics Explorer (DE) mission is designed to study the Earth's electromagnetic fields at varying heights up to 4 Earth radii. The DE-1 was launched on a Delta 3913 launch vehicle from the Western Test Range and was placed in a 561 x 23279 km orbit with a 90 degree inclination. The Deep Space Network (DSN) began to support this extended mission on February 1, 1985. Coverage consists of five passes per day that last for 45 minutes each. Information is given in tabular form for DSN support, frequency assignments, telemetry, command, and tracking mission responsibility.

  13. Maxie 1

    NASA Astrophysics Data System (ADS)

    Imhof, William L.; Voss, Henry D.; Chinn, Victor

    1987-12-01

    The satellite flight of the MAXIE-1 (Magnetospheric Atmospheric X-ray Imaging Experiment) instrument is being implemented under ONR (the Office of Naval Research) sponsorship. The MAXIE-1 instrument is being developed as a joint activity of Lockheed, the Aerospace Corporation, and the University of Bergen; much of the Lockheed development has been done under the Independent Research Program. Under ONR sponsorship that institution is responsible for managing the program, for providing spacecraft interface requirements, for providing interface activities undertaken in the last three months. Interactions have continued with co-investigators at the Aerospace Corp. and at the University of Bergen. NASTRAN model calculations, thermal analyses and an updated MAXIE assembly drawing and other drawings have been provided to RCA.

  14. Sirt1

    PubMed Central

    Fusco, Salvatore; Maulucci, Giuseppe; Pani, Giovambattista

    2012-01-01

    Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to “healthspan,” and a decline of Sirt-centered protective circuits over time may explain the “catastrophic” nature of aging. PMID:22983125

  15. Comparison of sulfur interaction with hydrogen on Pt(1 1 1), Ni(1 1 1) and Pt 3Ni(1 1 1) surfaces: The effect of intermetallic bonding

    NASA Astrophysics Data System (ADS)

    Pillay, D.; Johannes, M. D.

    2008-08-01

    Adsorption strengths of hydrogen and sulfur both individually and together as co-adsorbates were investigated on Pt(1 1 1), Ni(1 1 1) and Pt 3Ni(1 1 1) surfaces using density functional theory in order to determine the effect of metal alloying on sulfur tolerance. The adsorption strengths of H and S singly follow the same trend: Ni(1 1 1) > Pt(1 1 1) > Pt 3Ni(1 1 1), which correlates well with the respective d-band center positions of each surface. We find that the main effect of alloying is to distort both the sub-layer structure and the Pt overlayer resulting in a lowered d-band. For all three surfaces, the d-band shifts downward non-linearly as a function of S coverage. Nearly identical decreases in d-band position were calculated for each surface, leading to an expectation that subsequent adsorption of H would scale with surface type similarly to single species adsorption. In contradiction to this expectation, there was no clearly discernable difference between the energies of coadsorbed H on Pt(1 1 1) and Ni(1 1 1) and only a slightly lowered energy on Pt 3Ni(1 1 1). This provides evidence that coadsorbed species in close proximity interact directly through itinerant mobile electrons and through electrostatic repulsion rather than solely through the electronic structure of the surface. The combination of the lowered d-band position (arising from distorted geometry) and direct co-adsorbate interactions on Pt 3Ni(1 1 1) leads to a lower energy barrier for H 2S formation on the surface compared to pure Pt(1 1 1). Thus, alloying Pt with Ni both decreases the likelihood of S adsorption and favors S removal through H 2S formation.

  16. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES General Actuarial Valuations §§ 1.7872-11.7872-4...

  17. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations §§ 1.7872-11.7872-4...

  18. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations §§ 1.7872-11.7872-4...

  19. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations §§ 1.7872-11.7872-4...

  20. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  1. 26 CFR 1.7872-1-1.7872-4 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false 1.7872-1-1.7872-4 Section 1.7872-1-1.7872-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) General Actuarial Valuations §§ 1.7872-11.7872-4...

  2. RAP1GA1: A candidate tumor suppressor locus in 1p36.1

    SciTech Connect

    Ranade, K.; Hussussian, C.J.; Higgins, P.

    1994-09-01

    The rap1/Krev-1 gene (RAP1A) encodes a p21-related protein that suppresses transformation by activated p21{sup ras}. The GTPase activating protein (GAP) gene for p21{sup rap1A} (RAP1GA1) has recently been assigned to chromosome 1p36.1-p35, a region of the genome that is frequently involved in deletions and rearrangements in several different tumors including breast, colon and hepatocellular carcinomas, melanoma, and neuroblastoma. GAP genes negatively regulate the activity of p21 proteins by catalyzing the conversion of the active GTP-bound forms to the inactive GDP-bound forms. The physiological function of p21{sup rap1A}-GAP makes it a strong candidate as a tumor suppressor gene that may have a role in the development of one or more of these malignancies. We have refined the localization of RAP1GA1 by linkage analysis with a highly informative (CA){sub n} repeat contained within the gene, and demonstrated that it is within the minimal deleted region for breast and colon carcinomas, and that it is excluded from the minimally deleted region in melanoma and neuroblastoma. Genetic mapping in the mouse demonstrated that Rap1ga1 is located {approximately}10 cM proximal to Pnd and therefore maps within the interval containing the modifier of Min gene (Mom-1) and the plasmocytoma susceptibility locus (Pcts). The human RAP1GA1 gene contains at least 27 exons. The coding region contains 22 exons, and there are at least five 5{prime}-UT exons that are assembled in a complex pattern of alternative splicing in different tissues. The localization of RAP1GA1 makes it a very strong candidate for a role as a modifier gene involved in the common secondary abnormalities involving 1p36 in several different carcinomas. The potential role of RAP1GA1 in these malignancies is currently being investigated by sequence analysis of breast and colon carcinomas with loss of heterozygosity in 1p36.

  3. SPITFIRE-1

    NASA Technical Reports Server (NTRS)

    Ryntz, Edward F.

    1995-01-01

    The purpose of this effort is to develop low-cost rapid forming superplastic aluminum that will be evaluated in pilot production trials for automotive SPF components. The alloy development study conducted under SPITFIRE-1 showed that the addition of CU or Mn to the base 5083 aluminum alloy refined the grain size, leading to enhanced superplastic properties. In SPITFIRE-2, these alloy variants will be further refined and studied to meet the target properties established earlier in the program. Mechanical properties, component forming and post-forming properties will be evaluated. Also, the alloy production process, including thermomechanical processing (TMP) optimization to reduce production cost, will be investigated during SPITFIRE-2. After identifying preferred compositions and production processing, the most promising alloy will be manufactured into production coils for verification during SPITFIRE-3. Components will be produced from these coils in SPITFIRE-4, and the process and component performance will be assessed.

  4. Methane dissociation on Pt(1 1 1), Ir(1 1 1) and PtIr(1 1 1) surface: A density functional theory study

    NASA Astrophysics Data System (ADS)

    Qi, Qiuhong; Wang, Xiujun; Chen, Li; Li, Baitao

    2013-11-01

    A periodic density functional theory (DFT) was utilized to calculate the dissociation process of methane (CH4) on Pt(1 1 1), Ir(1 1 1) and PtIr(1 1 1) surfaces. As compared to the adsorption energy, the most stable configurations of methane, methane dissociation species and co-adsorption of CHx (x = 0-3) with H were obtained. The kinetic results of the CH4 dissociation indicated that the dissociating of CH4 into CH3 and H is the rate-limiting step on the PtIr(1 1 1) and Ir(1 1 1) surfaces. CH was the most abundant species that was difficult to dehydrogenate into C and H. Particularly, the activation barrier for CH3 → CH2 + H and CH2 → CH + H on the Pt(1 1 1) surface is 3.5 and 1.4 times, respectively, higher than that on the PtIr(1 1 1) surface. According to the thermodynamics principles, the successive dehydrogenation of CH4 preferred to take place on the PtIr surface.

  5. Cordoba Durchmusterung, volume 1

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The 'Cordoba Durchmusterung' (CD) is a visual survey of southern stars in the declination zones -22 to -89 deg, carried out as an extension to the 'Bonner Durchmusterung' (BD) catalogs of Argelander and Schoenfeld. This volume covers the declination range -22 deg through -30 deg. The survey was performed using techniques similar to those used for the BD; i.e., the stars were cataloged by allowing the telescope to drift along the mean declination of each zone and recording the positions and magnitudes of stars crossing the transit line of the field. The goal of the survey was to obtain a position and estimated visual magnitude for every star down to 10.0 magnitude inclusive, but the faint limit was confirmed from comparisons with other catalogs, to be somewhat below 10. The positions are given to 0.1 s in right ascension and 0.1 min in declination for the equinox 1875. The positional uncertainties quoted in the original publications are plus or minus 0.42 s and plus or minus 0.23 min for zones -22 deg to -32 deg. A list of all corrections made to the original data as a result of published corrigenda is presented. No other corrections or changes were incorporated into the original data, e.g., from more modern positions and magnitudes or comparison with the 'Cape Photographic Durchmusterung'.

  6. Stability and activity of lipase in subcritical 1,1,1,2-tetrafluoroethane (R134a).

    PubMed

    Yu, Gang; Xue, Yong; Xu, Wei; Zhang, Jing; Xue, Chang Hu

    2007-12-01

    The stability and activity of commercial immobilized lipase from Candida antarctica (Novozym 435) in subcritical 1,1,1,2-tetrafluoroethane (R134a) was investigated. The esterification of oleic acid with glycerol was studied as a model reaction in subcritical R134a and in solvent-free conditions. The results indicated that subcritical R134a treatment led to significant increase of activity of Novozym 435, and a maximum residual activity of 300% was measured at 4 MPa, 30 degrees C after 7 h incubation. No deactivation of Novozym 435 treated with subcritical R134a under different operation factors (pressure 2-8 MPa, temperature 30-60 degrees C, incubation time 1-12 h, water content 1:1, 1:2, 1:5 enzyme/water, depressurization rate 4 MPa/1 min, 4 MPa/30 min, 4 MPa/90 min) was observed. While the initial reaction rate was high in subcritical R134a, higher conversion was obtained in solvent-free conditions. Though the apparent conversion of the reaction is lower in subcritical R134a, it is more practicable, especially at low enzyme concentrations desired at commercial scales. PMID:17909872

  7. CH4 dehydrogenation on Cu(1 1 1), Cu@Cu(1 1 1), Rh@Cu(1 1 1) and RhCu(1 1 1) surfaces: A comparison studies of catalytic activity

    NASA Astrophysics Data System (ADS)

    Zhang, Riguang; Duan, Tian; Ling, Lixia; Wang, Baojun

    2015-06-01

    In the CVD growth of graphene, the reaction barriers of the dehydrogenation for hydrocarbon molecules directly decide the graphene CVD growth temperature. In this study, density functional theory method has been employed to comparatively probe into CH4 dehydrogenation on four types of Cu(1 1 1) surface, including the flat Cu(1 1 1) surface (labeled as Cu(1 1 1)) and the Cu(1 1 1) surface with one surface Cu atom substituted by one Rh atom (labeled as RhCu(1 1 1)), as well as the Cu(1 1 1) surface with one Cu or Rh adatom (labeled as Cu@Cu(1 1 1) and Rh@Cu(1 1 1), respectively). Our results show that the highest barrier of the whole CH4 dehydrogenation process is remarkably reduced from 448.7 and 418.4 kJ mol-1 on the flat Cu(1 1 1) and Cu@Cu(1 1 1) surfaces to 258.9 kJ mol-1 on RhCu(1 1 1) surface, and to 180.0 kJ mol-1 on Rh@Cu(1 1 1) surface, indicating that the adsorbed or substituted Rh atom on Cu catalyst can exhibit better catalytic activity for CH4 complete dehydrogenation; meanwhile, since the differences for the highest barrier between Cu@Cu(1 1 1) and Cu(1 1 1) surfaces are smaller, the catalytic behaviors of Cu@Cu(1 1 1) surface are very close to the flat Cu(1 1 1) surface, suggesting that the morphology of Cu substrate does not obviously affect the dehydrogenation of CH4, which accords with the reported experimental observations. As a result, the adsorbed or substituted Rh atom on Cu catalyst exhibit a better catalytic activity for CH4 dehydrogenation compared to the pure Cu catalyst, especially on Rh-adsorbed Cu catalyst, we can conclude that the potential of synthesizing high-quality graphene with the help of Rh on Cu foils may be carried out at relatively low temperatures. Meanwhile, the adsorbed Rh atom is the reaction active center, namely, the CVD growth can be controlled by manipulating the graphene nucleation position.

  8. Theoretical study of NH3 decomposition on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces: A comparison with clean Pd (1 1 1) and Cu (1 1 1)

    NASA Astrophysics Data System (ADS)

    Jiang, Zhao; Qin, Pei; Fang, Tao

    2016-05-01

    The adsorption and successive dehydrogenation mechanisms of NH3 on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces (the Pd atoms substitution of the first and second layers of Cu (1 1 1) surfaces) have been systematically investigated by density functional theory (DFT) method with a periodic slab model. All possible adsorption configurations of relevant intermediates on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces are identified. It is revealed that the adsorption configurations and corresponding adsorption energies of adsorbates are slightly changed on Pd-Cu (1 1 1) and Cu-Pd (1 1 1) surfaces. The adsorption energies of NHx(x = 0-3) species exhibit the following trend: NH3 < NH2 < NH < N. Then, the minimum energy path for the complete dehydrogenation of NH3 into adsorbed N and H is identified to explore the dehydrogenation mechanisms on different surfaces. The highest energy barrier and reaction energy on Pd-Cu (1 1 1) surface are greatly reduced to 1.56 and 0.99 eV, implying that the complete dehydrogenation of NH3 on Pd-Cu (1 1 1) surface is favorable both kinetically and thermodynamically, namely, the doped-Pd atoms in the first layer are the reaction active center. Compared to that on clean Pd (1 1 1) and Cu (1 1 1) surfaces, it is found that the synergistic effect exits in different layers of catalyst surfaces. The calculated results show that the layer-substituted Pd atoms on the surface of Cu catalysts exhibit a better catalytic activity for NH3 dehydrogenation compared to the clean Cu (1 1 1) surface.

  9. Extraction of astaxanthin from Euphausia pacific using subcritical 1, 1, 1, 2-tetrafluoroethane

    NASA Astrophysics Data System (ADS)

    Han, Yuqian; Ma, Qinchuan; Wang, Lan; Xue, Changhu

    2012-12-01

    Euphausia pacific is an important source of natural astaxanthin. Studies were carried out to assess the extractability of astaxanthin from E. pacific using subcritical 1, 1, 1, 2-tetrafluoroethane (R134a). To examine the effects of multiple process variables on the extraction yield, astaxanthin was extracted under various conditions of pressure (30-150 bar), temperature (303-343 K), time (10-50 min), flow rate (2-10 g min-1), moisture content (5.5%-63.61%), and particle size (0.25-0.109 mm). The results showed that the extraction yield increased with temperature, pressure, time and flow rate, but decreased with moisture content and particle size. A maximum yield of 87.74% was obtained under conditions of 100 bar, 333 K, and 30 min with a flow rate of 6 g min-1 and a moisture content of 5.5%. The substantial astaxanthin yield obtained under low-pressure conditions demonstrates that subcritical R134a is a good alternative to CO2 for extraction of astaxanthin from E. pacific.

  10. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  11. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  12. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  13. 26 CFR 1.453-1-1.453-2 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false 1.453-1-1.453-2 Section 1.453-1-1.453-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxable Year for Which Items of Gross Income Included §§ 1.453-11.453-2...

  14. 31 CFR 1.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General. 1.1 Section 1.1 Money and... § 1.1 General. (a) Purpose and scope. (1) This subpart contains the regulations of the Department of... legal counsel to the components listed in paragraphs (a)(1)(i)(W), (a)(1)(i)(X), (a)(1)(i)(Y), and...

  15. 31 CFR 1.1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false General. 1.1 Section 1.1 Money and... § 1.1 General. (a) Purpose and scope. (1) This subpart contains the regulations of the Department of... legal counsel to the components listed in paragraphs (a)(1)(i)(W), (a)(1)(i)(X), (a)(1)(i)(Y), and...

  16. 31 CFR 1.1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false General. 1.1 Section 1.1 Money and... § 1.1 General. (a) Purpose and scope. (1) This subpart contains the regulations of the Department of... legal counsel to the components listed in paragraphs (a)(1)(i)(W), (a)(1)(i)(X), (a)(1)(i)(Y), and...

  17. 31 CFR 1.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false General. 1.1 Section 1.1 Money and... § 1.1 General. (a) Purpose and scope. (1) This subpart contains the regulations of the Department of... legal counsel to the components listed in paragraphs (a)(1)(i)(W), (a)(1)(i)(X), (a)(1)(i)(Y), and...

  18. 31 CFR 1.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false General. 1.1 Section 1.1 Money and... § 1.1 General. (a) Purpose and scope. (1) This subpart contains the regulations of the Department of... legal counsel to the components listed in paragraphs (a)(1)(i)(W), (a)(1)(i)(X), (a)(1)(i)(Y), and...

  19. PHOTOCHEMISTRY IN AQUEOUS SURFACE LAYERS: 1-NAPHTHOL

    EPA Science Inventory

    1-Naphthol was reactive toward direct photolysis in buffered aqueous solutions (at pH 7, halflife in sunlight was about 90 min) and in cyclohexane (halflife about 15 min). The reaction rate in water increased with pH. The mechanisms of the principal photolysis pathways in both so...

  20. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  1. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  2. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  3. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... terms when used in regulations promulgated under that act. (c) The definition of package in § 1.20...

  4. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  5. 14 CFR 1.1 - General definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false General definitions. 1.1 Section 1.1... AND ABBREVIATIONS § 1.1 General definitions. As used in Subchapters A through K of this chapter... include: (1) An ATS route designator; (2) The path to or from significant points; (3) Distance...

  6. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  7. 8 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Definitions. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Definitions. As used in this... Service means the Immigration and Naturalization Service, as it existed prior to March 1, 2003....

  8. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  9. 14 CFR 1.1 - General definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false General definitions. 1.1 Section 1.1... AND ABBREVIATIONS § 1.1 General definitions. As used in Subchapters A through K of this chapter... include: (1) An ATS route designator; (2) The path to or from significant points; (3) Distance...

  10. 16 CFR 1.1 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Policy. 1.1 Section 1.1 Commercial Practices... Guidance Advisory Opinions § 1.1 Policy. (a) Any person, partnership, or corporation may request advice... Commission's views, where practicable, under the following circumstances. (1) The matter involves...

  11. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  12. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  13. 24 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Purpose. 1.1 Section 1.1 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.1 Purpose. The purpose of this part 1 is to effectuate...

  14. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It is...

  15. Surface relaxation of Pt(1 1 1) and Cu/Pt(1 1 1) revealed by DEPES

    NASA Astrophysics Data System (ADS)

    Miszczuk, A.; Morawski, I.; Kucharczyk, R.; Nowicki, M.

    2016-06-01

    In this paper, we report the results of surface relaxation investigations for a clean Pt(1 1 1) as well as Pt(1 1 1) covered with a pseudomorphic monolayer of Cu. The pseudomorphic (1 × 1) Cu overlayer on Pt(1 1 1) was formed upon continuous copper adsorption at the substrate temperature equal to 450 K. Considerations include both the experimental and theoretical studies employing directional elastic peak electron spectroscopy (DEPES), multiple scattering (MS) formalism, and density functional theory (DFT). A quantitative analysis of two-dimensional DEPES intensity distributions is presented and the contribution of consecutive subsurface Pt atomic layers to the measured signal is identified. The experimental DEPES distributions are compared with theoretical maps MS-simulated for a variable separation between the outermost atomic planes. For the clean Pt(1 1 1), the best fit is obtained assuming the outward relaxation of the surface layer by +0.7% with respect to the interplanar distance in the bulk, confirming the slight expansion of the Pt(1 1 1) surface. Similar analysis performed for the Cu/Pt(1 1 1) adsorption system indicates the inward shift of the pseudomorphic Cu overlayer by -6.9% with respect to the substrate lattice continuation sites. Such DEPES-determined surface relaxations of Pt(1 1 1) and Cu/Pt(1 1 1) agree with the values predicted by the corresponding DFT computations.

  16. Differential affinities of MinD and MinE to anionic phospholipid influence Min Patterning dynamics in vitro

    PubMed Central

    Vecchiarelli, Anthony G.; Li, Min; Mizuuchi, Michiyo; Mizuuchi, Kiyoshi

    2014-01-01

    The E. coli Min system forms a cell-pole-to-cell-pole oscillator that positions the divisome at mid-cell. The MinD ATPase binds the membrane and recruits the cell division inhibitor MinC. MinE interacts with and releases MinD (and MinC) from the membrane. The chase of MinD by MinE creates the in vivo oscillator that maintains a low level of the division inhibitor at mid-cell. In vitro reconstitution and visualization of Min proteins on a supported lipid bilayer has provided significant advances in understanding Min patterns in vivo. Here we studied the effects of flow, lipid composition, and salt concentration on Min patterning. Flow and no-flow conditions both supported Min protein patterns with somewhat different characteristics. Without flow, MinD and MinE formed spiraling waves. MinD and, to a greater extent MinE, have stronger affinities for anionic phospholipid. MinD-independent binding of MinE to anionic lipid resulted in slower and narrower waves. MinE binding to the bilayer was also more susceptible to changes in ionic strength than MinD. We find that modulating protein diffusion with flow, or membrane binding affinities with changes in lipid composition or salt concentration, can differentially affect the retention time of MinD and MinE, leading to spatiotemporal changes in Min patterning. PMID:24930948

  17. 18 CFR 1b.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 1b.1 Section 1b.1 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES RULES RELATING TO INVESTIGATIONS § 1b.1 Definitions. For purposes of this part—...

  18. 33 CFR 1.08-1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Applicability. 1.08-1 Section 1.08-1 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Written Warnings by Coast Guard Boarding Officers § 1.08-1 Applicability. (a) The regulations in this subpart apply to certain violations...

  19. 26 CFR 1.1083-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Definitions. 1.1083-1 Section 1.1083-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Exchanges in Obedience to S.e.c. Orders § 1.1083-1 Definitions. (a) Order of the Securities and Exchange Commission. (1)...

  20. 26 CFR 1.150-1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Definitions. 1.150-1 Section 1.150-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Tax Exemption Requirements for State and Local Bonds § 1.150-1 Definitions. (a) Scope and effective date—(1) In general. Except...

  1. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  2. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  3. 17 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false 1.1 Section 1.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.1...

  4. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  5. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... implementation of paragraph (a) is contained in 44 CFR part 5, subpart B. (c) This part contains policies and... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic...

  6. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  7. 49 CFR 1.1 - Overview.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Overview. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Overview. This part describes the organization of the United States Department of Transportation...

  8. 17 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false 1.1 Section 1.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.1...

  9. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  10. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... implementation of paragraph (a) is contained in 44 CFR part 5, subpart B. (c) This part contains policies and... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic...

  11. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  12. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  13. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  14. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  15. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  16. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  17. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... implementation of paragraph (a) is contained in 44 CFR part 5, subpart B. (c) This part contains policies and... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic...

  18. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  19. 49 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Purpose. This part describes the organization of the Department of Transportation and provides for...

  20. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  1. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  2. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  3. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  4. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  5. 27 CFR 1.1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false General. 1.1 Section 1.1 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE... OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Scope § 1.1 General....

  6. 30 CFR 1.1 - Official emblem.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Official emblem. 1.1 Section 1.1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND OMB CONTROL NUMBERS... OFFICIAL EMBLEM § 1.1 Official emblem. The following emblem is established and shall be used as...

  7. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  8. 49 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Purpose. This part describes the organization of the Department of Transportation and provides for...

  9. 49 CFR 1.1 - Overview.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Overview. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Overview. This part describes the organization of the United States Department of Transportation...

  10. 8 CFR 1.1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Applicability. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Applicability. This part further defines some of the terms already described in section 101 and other sections of the...

  11. 8 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Definitions. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Definitions. As used in this...) The term Service means the Immigration and Naturalization Service, as it existed prior to March...

  12. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  13. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  14. 49 CFR 1.1 - Overview.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Overview. 1.1 Section 1.1 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.1 Overview. This part describes the organization of the United States Department of Transportation...

  15. 17 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false 1.1 Section 1.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.1...

  16. 8 CFR 1.1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Applicability. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Applicability. This part further defines some of the terms already described in section 101 and other sections of the...

  17. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  18. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  19. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  20. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  1. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  2. 15 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Purpose. 1.1 Section 1.1 Commerce and Foreign Trade Office of the Secretary of Commerce THE SEAL OF THE DEPARTMENT OF COMMERCE § 1.1 Purpose. The purpose of this part is to describe the seal of the Department of Commerce and to...

  3. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  4. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  5. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... implementation of paragraph (a) is contained in 44 CFR part 5, subpart B. (c) This part contains policies and... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic...

  6. 23 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Purpose. 1.1 Section 1.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL MANAGEMENT AND ADMINISTRATION GENERAL § 1.1 Purpose. The purpose of the regulations in this part is to implement and carry out the provisions of Federal...

  7. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  8. 36 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Purpose. 1.1 Section 1.1 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.1 Purpose. (a) The regulations in this chapter provide for the proper use, management,...

  9. 17 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false 1.1 Section 1.1 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.1...

  10. 44 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... implementation of paragraph (a) is contained in 44 CFR part 5, subpart B. (c) This part contains policies and... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Purpose. 1.1 Section 1.1... GENERAL RULEMAKING; POLICY AND PROCEDURES General § 1.1 Purpose. (a) This part contains the basic...

  11. 43 CFR 1.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Purpose. 1.1 Section 1.1 Public Lands: Interior Office of the Secretary of the Interior PRACTICES BEFORE THE DEPARTMENT OF THE INTERIOR § 1.1 Purpose. This part governs the participation of individuals in proceedings, both formal and informal,...

  12. 25 CFR 1.1 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false 1.1 Section 1.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.1...

  13. 8 CFR 1.1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Applicability. 1.1 Section 1.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.1 Applicability. This part further defines some of the terms already described in section 101 and other sections of the...

  14. 43 CFR 1784.1-1 - Establishment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Establishment. 1784.1-1 Section 1784.1-1..., DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) COOPERATIVE RELATIONS Advisory Committees § 1784.1-1... Secretary has— (1) Determined as a matter of formal record, after consultation with the General...

  15. 43 CFR 2563.1-1 - Application.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Application. 2563.1-1 Section 2563.1-1... § 2563.1-1 Application. (a) Form and contents of applications. Applications under the Act of March 3... facts: (1) The age and citizenship of applicant. (2) The actual use and occupancy of the land for...

  16. 26 CFR 2.1-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Definitions. 2.1-1 Section 2.1-1 Internal... CONSTRUCTION RESERVE FUND § 2.1-1 Definitions. (a) As used in the regulations in this part, except as otherwise expressly provided— (1) Act means the Merchant Marine Act, 1936, as amended (46 U.S.C. 27). (2)...

  17. 43 CFR 2563.1-1 - Application.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Application. 2563.1-1 Section 2563.1-1... § 2563.1-1 Application. (a) Form and contents of applications. Applications under the Act of March 3... facts: (1) The age and citizenship of applicant. (2) The actual use and occupancy of the land for...

  18. 43 CFR 2563.1-1 - Application.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Application. 2563.1-1 Section 2563.1-1... § 2563.1-1 Application. (a) Form and contents of applications. Applications under the Act of March 3... facts: (1) The age and citizenship of applicant. (2) The actual use and occupancy of the land for...

  19. 43 CFR 1784.1-1 - Establishment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Establishment. 1784.1-1 Section 1784.1-1..., DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) COOPERATIVE RELATIONS Advisory Committees § 1784.1-1... Secretary has— (1) Determined as a matter of formal record, after consultation with the General...

  20. 43 CFR 1784.1-1 - Establishment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Establishment. 1784.1-1 Section 1784.1-1..., DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) COOPERATIVE RELATIONS Advisory Committees § 1784.1-1... Secretary has— (1) Determined as a matter of formal record, after consultation with the General...

  1. 43 CFR 9180.1-1 - Meridians.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Meridians. 9180.1-1 Section 9180.1-1..., DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Cadastral Surveys; General § 9180.1-1... production, in accordance with section 1 of the Act of August 24, 1912 (37 Stat. 497), as amended (5...

  2. 43 CFR 8365.1-1 - Sanitation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Sanitation. 8365.1-1 Section 8365.1-1..., DEPARTMENT OF THE INTERIOR RECREATION PROGRAMS VISITOR SERVICES Rules of Conduct § 8365.1-1 Sanitation. (a... person shall, unless otherwise authorized: (1) Dispose of any cans, bottles and other nonflammable...

  3. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... in §§ 101.1, 201.60, 501.1, 701.10 and 801.60 of this chapter; and the requirements pertaining...

  4. 26 CFR 1.307-1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... to such stock. 1,900/12,900 of $10,000=$1,472.87, cost of old stock apportioned to rights. If the... 26 Internal Revenue 4 2013-04-01 2013-04-01 false General. 1.307-1 Section 1.307-1 Internal... TAXES (CONTINUED) Effects on Recipients § 1.307-1 General. (a) If a shareholder receives stock or...

  5. 26 CFR 1.307-1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... stock. 1,900/12,900 of $10,000=$1,472.87, cost of old stock apportioned to rights. If the rights are... 26 Internal Revenue 4 2011-04-01 2011-04-01 false General. 1.307-1 Section 1.307-1 Internal... TAXES Effects on Recipients § 1.307-1 General. (a) If a shareholder receives stock or stock rights as...

  6. 26 CFR 1.307-1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... to such stock. 1,900/12,900 of $10,000=$1,472.87, cost of old stock apportioned to rights. If the... 26 Internal Revenue 4 2012-04-01 2012-04-01 false General. 1.307-1 Section 1.307-1 Internal... TAXES (Continued) Effects on Recipients § 1.307-1 General. (a) If a shareholder receives stock or...

  7. 26 CFR 1.307-1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... to such stock. 1,900/12,900 of $10,000=$1,472.87, cost of old stock apportioned to rights. If the... 26 Internal Revenue 4 2014-04-01 2014-04-01 false General. 1.307-1 Section 1.307-1 Internal... TAXES (CONTINUED) Effects on Recipients § 1.307-1 General. (a) If a shareholder receives stock or...

  8. 21 CFR 1.1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false General. 1.1 Section 1.1 Food and Drugs FOOD AND... General Provisions § 1.1 General. (a) The provisions of regulations promulgated under the Federal Food... promulgated under that act. (c) The definition of package in § 1.20 and of principal display panel in §§...

  9. 41 CFR 51-1.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Policy. 51-1.1 Section 51-1.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 1-GENERAL § 51-1.1 Policy. (a) It is the policy of the Government to increase...

  10. Safety in the Laboratory: 1,1,1-Trichloroethane.

    ERIC Educational Resources Information Center

    Rothchild, Robert

    1983-01-01

    Discusses use of 1,1,1-trichloroethane as a substitute for carbon tetrachloride. Provides information on additives to commercially supplied sources in relation to possible reaction interferences. Warns of toxicity and possible carcinogenic action. (JM)

  11. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  12. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  13. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public... OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods § 9185.1-1 Surveys. (a) Original surveys. Application for the original extension of the rectangular system of...

  14. 26 CFR 1.936-1 - Elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 10 2011-04-01 2011-04-01 false Elections. 1.936-1 Section 1.936-1 Internal... TAXES (CONTINUED) Possessions of the United States § 1.936-1 Elections. (a) Making an election. A domestic corporation shall make an election under section 936(e), for any taxable year beginning...

  15. 26 CFR 1.936-1 - Elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Elections. 1.936-1 Section 1.936-1 Internal... TAXES Possessions of the United States § 1.936-1 Elections. (a) Making an election. A domestic corporation shall make an election under section 936(e), for any taxable year beginning after December...

  16. 26 CFR 1.936-1 - Elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 10 2013-04-01 2013-04-01 false Elections. 1.936-1 Section 1.936-1 Internal... TAXES (CONTINUED) Possessions of the United States § 1.936-1 Elections. (a) Making an election. A domestic corporation shall make an election under section 936(e), for any taxable year beginning...

  17. 26 CFR 1.936-1 - Elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 10 2012-04-01 2012-04-01 false Elections. 1.936-1 Section 1.936-1 Internal... TAXES (CONTINUED) Possessions of the United States § 1.936-1 Elections. (a) Making an election. A domestic corporation shall make an election under section 936(e), for any taxable year beginning...

  18. 43 CFR 3135.1-1 - Transfers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Transfers. 3135.1-1 Section 3135.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Transfers, Extensions, Consolidations, and Suspensions § 3135.1-1 Transfers. (a) Subject to approval of...

  19. 26 CFR 1.1481-1 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false 1.1481-1 Section 1.1481-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Mitigation of Effect of Renegotiation of Government Contracts § 1.1481-1 Tax on Transfers To Avoid Income Tax...

  20. 26 CFR 1.581-1 - Banks.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 7 2012-04-01 2012-04-01 false Banks. 1.581-1 Section 1.581-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.581-1 Banks. (a) In order to be a bank as defined in section 581,...

  1. 26 CFR 1.581-1 - Banks.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Banks. 1.581-1 Section 1.581-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.581-1 Banks. (a) In order to be a bank as defined in section 581,...

  2. 26 CFR 1.581-1 - Banks.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Banks. 1.581-1 Section 1.581-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.581-1 Banks. (a) In order to be a bank as defined in section 581,...

  3. 26 CFR 1.581-1 - Banks.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 7 2014-04-01 2013-04-01 true Banks. 1.581-1 Section 1.581-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.581-1 Banks. (a) In order to be a bank as defined in section 581,...

  4. 26 CFR 1.581-1 - Banks.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 7 2013-04-01 2013-04-01 false Banks. 1.581-1 Section 1.581-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.581-1 Banks. (a) In order to be a bank as defined in section 581,...

  5. IRIS Update Batch 1, Group 1

    EPA Science Inventory

    Update the following IRIS chemical dose-response assessments: Barium (cancer, RfC), o-Cresol (RfD, cancer), carbon disulfied (RfD, RfC), 1,1-Dichloroethane (cancer), 2,4-Dimethylphenol (RfD), 1,4-Dibromobenzene (RfD), 1-chloro-1,1-difluroelfane (RfC, Acetyl chloride (cancer),2,4...

  6. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a), (b), or (c)...

  7. 26 CFR 1.875-1 - Partnerships.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Partnerships. 1.875-1 Section 1.875-1 Internal... TAXES (CONTINUED) Nonresident Aliens and Foreign Corporations § 1.875-1 Partnerships. Whether a nonresident alien individual who is a member of a partnership is taxable in accordance with subsection (a),...

  8. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  9. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  10. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  11. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  12. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  13. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  14. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  15. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  16. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  17. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  18. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  19. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  20. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  1. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  2. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  3. 1 CFR 20.1 - Liaison officers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Liaison officers. 20.1 Section 20.1 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.1 Liaison officers. (a) Each of... United States Government Manual: (1) Agencies of the legislative and judicial branches. (2)...

  4. 1 CFR 19.1 - Form.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Form. 19.1 Section 19.1 General Provisions... ORDERS AND PRESIDENTIAL PROCLAMATIONS § 19.1 Form. Proposed Executive orders and proclamations shall be... Tracts of Land for Use in Executive Orders and Proclamations,”1 prepared by the Bureau of Land...

  5. 1 CFR 5.1 - Publication policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication policy. 5.1 Section 5.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.1 Publication...: (1) Executive orders, proclamations, and other Presidential documents. (2) Documents required to...

  6. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  7. 1 CFR 16.1 - Designation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Designation. 16.1 Section 16.1 General... DOCUMENTS AGENCY REPRESENTATIVES § 16.1 Designation. (a) Each agency shall designate, from its officers or...: (1) A liaison officer and an alternate. (2) A certifying officer and an alternate. (3) An...

  8. 7 CFR 301.1-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 5 2011-01-01 2011-01-01 false Definitions. 301.1-1 Section 301.1-1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Preemption and Special Need Requests § 301.1-1 Definitions. Administrator. The Administrator,...

  9. 45 CFR 1210.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1210.1-1 Section 1210.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-1 Purpose. This...

  10. 43 CFR 3440.1-1 - Forms.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Bureau of Land Management State Office having jurisdiction over the lands involved (43 CFR subpart 1821... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Forms. 3440.1-1 Section 3440.1-1 Public... OF THE INTERIOR MINERALS MANAGEMENT (3000) LICENSES TO MINE Licenses to Mine § 3440.1-1 Forms....

  11. 45 CFR 1211.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1211.1-1 Section 1211.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-1 Purpose. This part establishes procedures under which certain...

  12. 26 CFR 303.1-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Custodian whose functions were transferred to the Attorney General pursuant to Executive Order 9788 (3 CFR... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Definitions. 303.1-1 Section 303.1-1 Internal... TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1-1 Definitions. (a) General. When used in this...

  13. 26 CFR 302.1-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Definitions. 302.1-1 Section 302.1-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-1 Definitions....

  14. 43 CFR 3452.1-1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false General. 3452.1-1 Section 3452.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT..., and Termination § 3452.1-1 General. The lessee may surrender the entire lease, a legal...

  15. 43 CFR 2812.1-1 - Filing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Filing. 2812.1-1 Section 2812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... Bay Revested Lands § 2812.1-1 Filing. (a) An application for a permit for a right-of-way over the...

  16. 43 CFR 3440.1-1 - Forms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Bureau of Land Management State Office having jurisdiction over the lands involved (43 CFR subpart 1821... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Forms. 3440.1-1 Section 3440.1-1 Public... OF THE INTERIOR MINERALS MANAGEMENT (3000) LICENSES TO MINE Licenses to Mine § 3440.1-1 Forms....

  17. 45 CFR 1211.1-1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1211.1-1 Section 1211.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-1 Purpose. This part establishes procedures under which certain...

  18. 26 CFR 303.1-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Custodian whose functions were transferred to the Attorney General pursuant to Executive Order 9788 (3 CFR... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Definitions. 303.1-1 Section 303.1-1 Internal... TAXES UNDER THE TRADING WITH THE ENEMY ACT § 303.1-1 Definitions. (a) General. When used in this...

  19. 43 CFR 3191.1-1 - Petition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Petition. 3191.1-1 Section 3191.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-1 Petition. The Governor or...

  20. 45 CFR 1216.1-1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Purpose. 1216.1-1 Section 1216.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-1 Purpose. This...

  1. 45 CFR 1220.1-1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Introduction. 1220.1-1 Section 1220.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PAYMENT OF VOLUNTEER LEGAL EXPENSES General § 1220.1-1 Introduction. Section 419 of the Domestic...

  2. 45 CFR 1216.1-1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1216.1-1 Section 1216.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-1 Purpose. This...

  3. 45 CFR 1210.1-1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1210.1-1 Section 1210.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-1 Purpose. This...

  4. 26 CFR 302.1-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Definitions. 302.1-1 Section 302.1-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-1 Definitions....

  5. 43 CFR 2812.1-1 - Filing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Filing. 2812.1-1 Section 2812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... Bay Revested Lands § 2812.1-1 Filing. (a) An application for a permit for a right-of-way over the...

  6. 45 CFR 1220.1-1 - Introduction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Introduction. 1220.1-1 Section 1220.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PAYMENT OF VOLUNTEER LEGAL EXPENSES General § 1220.1-1 Introduction. Section 419 of the Domestic...

  7. 43 CFR 2812.1-1 - Filing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Filing. 2812.1-1 Section 2812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... Bay Revested Lands § 2812.1-1 Filing. (a) An application for a permit for a right-of-way over the...

  8. 43 CFR 3191.1-1 - Petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Petition. 3191.1-1 Section 3191.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT... CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-1 Petition. The Governor or...

  9. 43 CFR 3452.1-1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false General. 3452.1-1 Section 3452.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT..., and Termination § 3452.1-1 General. The lessee may surrender the entire lease, a legal...

  10. 26 CFR 1.535-1 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Definition. 1.535-1 Section 1.535-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Corporations Used to Avoid Income Tax on Shareholders § 1.535-1 Definition. (a)...

  11. 26 CFR 1.556-1 - Definition.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Definition. 1.556-1 Section 1.556-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Foreign Personal Holding Companies § 1.556-1 Definition. Undistributed...

  12. 45 CFR 1210.1-1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Purpose. 1210.1-1 Section 1210.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-1 Purpose. This part establishes procedures under which...

  13. 45 CFR 1216.1-1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Purpose. 1216.1-1 Section 1216.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-1 Purpose. This part establishes rules to assure that...

  14. 45 CFR 1211.1-1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Purpose. 1211.1-1 Section 1211.1-1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-1 Purpose. This part establishes procedures under which certain volunteers enrolled under Pub. L. 93-113...

  15. Composition and structure of chemically prepared GaAs(1 1 1)A and (1 1 1)B surfaces

    NASA Astrophysics Data System (ADS)

    Tereshchenko, O. E.; Alperovich, V. L.; Terekhov, A. S.

    2006-02-01

    The (1 1 1)A and (1 1 1)B surfaces of GaAs chemically treated in HCl-isopropanol solution (HCl-iPA) and annealed in vacuum were studied by means of X-ray photoelectron spectroscopy (XPS), low-energy electron diffraction (LEED) and electron energy loss spectroscopy (EELS). To avoid uncontrolled contamination, chemical treatment and sample transfer into UHV were performed under pure nitrogen atmosphere. The HCl-iPA treatment removes gallium and arsenic oxides, with about 0.5-3 ML of elemental arsenic being left on the surface, depending on the crystallographic orientation. With the increase of the annealing temperature, a sequence of reconstructions were identified by LEED: (1 × 1) and (2 × 2) on the (1 1 1)A surface and (1 × 1), (2 × 2), (1 × 1), (3 × 3), (√19 × √19) on the (1 1 1)B surface. These sequences of reconstructions correspond to the decrease of surface As concentration. The structural properties of chemically prepared GaAs(1 1 1) surfaces were found to be similar to those obtained by decapping of As-capped epitaxial layers.

  16. 43 CFR 3135.1-1 - Transfers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Transfers. 3135.1-1 Section 3135.1-1... Transfers, Extensions, Consolidations, and Suspensions § 3135.1-1 Transfers. (a) Subject to approval of the... subdivision, to anyone qualified under §§ 3130.1 and 3132.4 of this title to hold a lease. (b) Any...

  17. 43 CFR 3135.1-1 - Transfers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Transfers. 3135.1-1 Section 3135.1-1... Transfers, Extensions, Consolidations, and Suspensions § 3135.1-1 Transfers. (a) Subject to approval of the... subdivision, to anyone qualified under §§ 3130.1 and 3132.4 of this title to hold a lease. (b) Any...

  18. 43 CFR 3135.1-1 - Transfers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Transfers. 3135.1-1 Section 3135.1-1... Transfers, Extensions, Consolidations, and Suspensions § 3135.1-1 Transfers. (a) Subject to approval of the... subdivision, to anyone qualified under §§ 3130.1 and 3132.4 of this title to hold a lease. (b) Any...

  19. The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis.

    SciTech Connect

    Park, Kyung-Tase; Wu, Wei; Battaile, Kevin P.; Lovell, Scott; Holyoak, Todd; Lutkenhaus, Joe

    2011-09-16

    In E. coli, MinD recruits MinE to the membrane, leading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring. How these proteins interact, however, is not clear because the MinD-binding regions of MinE are sequestered within a six-stranded {beta} sheet and masked by N-terminal helices. minE mutations that restore interaction between some MinD and MinE mutants were isolated. These mutations alter the MinE structure leading to release of the MinD-binding regions and the N-terminal helices that bind the membrane. Crystallization of MinD-MinE complexes revealed a four-stranded {beta} sheet MinE dimer with the released {beta} strands (MinD-binding regions) converted to {alpha} helices bound to MinD dimers. These results identify the MinD-dependent conformational changes in MinE that convert it from a latent to an active form and lead to a model of how MinE persists at the MinD-membrane surface.

  20. Vapor-liquid equilibria for the systems composed of 1-chloro-1,1-difluoroethane, 1,1-dichloro-1-fluoroethane, and 1,1,1-trichloroethane at 50.1 C

    SciTech Connect

    Kang, Y.W.; Lee, Y.Y.

    1996-03-01

    Isothermal vapor-liquid equilibria for the three binary systems 1-chloro-1,1-difluoroethane + 1,1-dichloro-1-fluoroethane, 1-chloro-1,1-difluoroethane + 1,1,1-trichloroethane, and 1,1-dichloro-1-fluoroethane + 1,1,1-trichloroethane and the ternary system 1-chloro-1,1-difluoromethane + 1,1-dichloro-1-fluoroethane + 1,1,1-trichloroethane have been measured at 50.1 C. The experimental data for the binary systems are correlated with the Peng-Robinson equation of state, and the relevant parameters are presented. The predicted results for the ternary system were found to be in good agreement with the experimental data.

  1. 26 CFR 1.508-1 - Notices.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Notices. 1.508-1 Section 1.508-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES... they are applying for recognition of section 501(c)(3) status—(1) In general. Except as provided...

  2. 48 CFR 1.602-1 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Authority. 1.602-1 Section... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.602-1 Authority. (a) Contracting officers have authority to enter into, administer, or terminate contracts...

  3. 43 CFR 9180.1-1 - Meridians.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... production, in accordance with section 1 of the Act of August 24, 1912 (37 Stat. 497), as amended (5 U.S.C..., DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Cadastral Surveys; General § 9180.1-1... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Meridians. 9180.1-1 Section...

  4. 48 CFR 1.102-1 - Discussion.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... procedures in the FAR. (b) Vision. All participants in the System are responsible for making acquisition... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Discussion. 1.102-1 Section 1.102-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL...

  5. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Register Act (1 CFR Ch. I); and (4) The acts which require publication in the Federal Register (See CFR volume entitled “CFR Index and Finding Aids.”) (c) The Director will assume in carrying out the... 1 General Provisions 1 2011-01-01 2011-01-01 false Policy. 51.1 Section 51.1 General...

  6. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  7. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  8. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  9. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Federal Register Index and LSA (List of CFR Sections Affected) are included with each Federal Register... 1 General Provisions 1 2011-01-01 2011-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  10. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Federal Register Index and LSA (List of CFR Sections Affected) are included with each Federal Register... 1 General Provisions 1 2014-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  11. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  12. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  13. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Federal Register Index and LSA (List of CFR Sections Affected) are included with each Federal Register... 1 General Provisions 1 2012-01-01 2012-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  14. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Register Act (1 CFR Ch. I); and (4) The acts which require publication in the Federal Register (See CFR volume entitled “CFR Index and Finding Aids.”) (c) The Director will assume in carrying out the... 1 General Provisions 1 2012-01-01 2012-01-01 false Policy. 51.1 Section 51.1 General...

  15. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  16. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  17. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Register Act (1 CFR Ch. I); and (4) The acts which require publication in the Federal Register (See CFR volume entitled “CFR Index and Finding Aids.”) (c) The Director will assume in carrying out the... 1 General Provisions 1 2013-01-01 2012-01-01 true Policy. 51.1 Section 51.1 General...

  18. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  19. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Register Act (1 CFR Ch. I); and (4) The acts which require publication in the Federal Register (See CFR volume entitled “CFR Index and Finding Aids.”) (c) The Director will assume in carrying out the... 1 General Provisions 1 2010-01-01 2010-01-01 false Policy. 51.1 Section 51.1 General...

  20. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  1. 1 CFR 304.1 - General provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false General provisions. 304.1 Section 304.1 General Provisions ADMINISTRATIVE CONFERENCE OF THE UNITED STATES DISCLOSURE OF RECORDS OR INFORMATION Procedures for Disclosure of Records Under the Freedom of Information Act § 304.1 General provisions. (a) This...

  2. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Federal Register Index and LSA (List of CFR Sections Affected) are included with each Federal Register... 1 General Provisions 1 2013-01-01 2012-01-01 true Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  3. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  4. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  5. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. The Director of the Federal Register...

  6. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. (a) The Director publishes a special...

  7. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  8. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  9. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  10. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  11. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  12. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  13. 1 CFR 304.1 - General provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true General provisions. 304.1 Section 304.1 General Provisions ADMINISTRATIVE CONFERENCE OF THE UNITED STATES DISCLOSURE OF RECORDS OR INFORMATION Procedures for Disclosure of Records Under the Freedom of Information Act § 304.1 General provisions. (a) This...

  14. 1 CFR 12.1 - Federal Register.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Federal Register Index and LSA (List of CFR Sections Affected) are included with each Federal Register... 1 General Provisions 1 2010-01-01 2010-01-01 false Federal Register. 12.1 Section 12.1 General... PUBLICATIONS OFFICIAL DISTRIBUTION WITHIN FEDERAL GOVERNMENT § 12.1 Federal Register. (a) Copies of the...

  15. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  16. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  17. 1 CFR 8.1 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of...

  18. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  19. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  20. 1 CFR 9.1 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 9.1 Section 9.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER THE UNITED STATES GOVERNMENT MANUAL § 9.1 Publication required. The Director of the Federal Register...

  1. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  2. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  3. 1 CFR 51.1 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Register Act (1 CFR Ch. I); and (4) The acts which require publication in the Federal Register (See CFR volume entitled “CFR Index and Finding Aids.”) (c) The Director will assume in carrying out the... 1 General Provisions 1 2014-01-01 2012-01-01 true Policy. 51.1 Section 51.1 General...

  4. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  5. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  6. 1 CFR 304.1 - General provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true General provisions. 304.1 Section 304.1 General Provisions ADMINISTRATIVE CONFERENCE OF THE UNITED STATES DISCLOSURE OF RECORDS OR INFORMATION Procedures for Disclosure of Records Under the Freedom of Information Act § 304.1 General provisions. (a) This...

  7. 1 CFR 3.1 - Information services.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Information services. 3.1 Section 3.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER GENERAL SERVICES TO THE PUBLIC § 3.1 Information services. Except in cases where the time required would be excessive, information concerning...

  8. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  9. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  10. 1 CFR 456.1 - Introduction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Introduction. 456.1 Section 456.1 General Provisions MISCELLANEOUS AGENCIES NATIONAL CAPITAL PLANNING COMMISSION (FREEDOM OF INFORMATION ACT REGULATIONS) § 456.1 Introduction. The following regulations implement the Freedom of Information Act,...

  11. 1 CFR 15.1 - Cooperation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Cooperation. 15.1 Section 15.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS SERVICES TO FEDERAL AGENCIES General § 15.1 Cooperation. The Director of the Federal...

  12. 1 CFR 21.1 - Drafting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  13. 48 CFR 1.602-1 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Authority. 1.602-1 Section 1.602-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities...

  14. CheMin Instrument Performance and Calibration on Mars

    NASA Technical Reports Server (NTRS)

    Vaniman, D. T.; Blake, D. F.; Morookian, J. M.; Yen, A. S.; Ming, D. W.; Morris, R. V.; Achilles, C. N.; Bish, D. L.; Chipera, S. J.; Morrison, S. M.; Downs, R. T.; Rampe, E. B.; Sarrazin, P. C.; Treiman, A. H.; Anderson, R. C.; Bristow, T. F.; Crisp, J. A.; Des Marais, D. J.; Spanovich, N.; Wilson, M. A.

    2013-01-01

    The CheMin (Chemistry and Mineralogy) instrument on the Mars Science Laboratory rover Curiosity uses a CCD detector and a Co-anode X-ray tube source to acquire both mineralogy (from the pattern of Co diffraction) and chemical information (from energies of fluoresced X-rays). A key component of the CheMin instrument is the ability to move grains within sample cells during analysis, providing multiple, random grain orientations that disperse diffracted X-ray photons along Debye rings rather than producing discrete Laue spots. This movement is accomplished by piezoelectric vibration of the sample cells. A cryocooler is used to maintain the CCD at a temperature at about -50 C in order to obtain energy resolution better than 250 eV, allowing discrimination of diffracted Co K X-rays from Fe K and other fluorescent X-rays. A detailed description of CheMin is provided in [1]. The CheMin flight model (FM) is mounted within the body of Curiosity and has been operating on Mars since August 6, 2012. An essentially identical sister instrument, the CheMin demonstration model (DM), is operated in a Mars environment chamber at JPL.

  15. Improved data analysis for the MinION nanopore sequencer

    PubMed Central

    Jain, Miten; Fiddes, Ian; Miga, Karen H.; Olsen, Hugh E.; Paten, Benedict; Akeson, Mark

    2016-01-01

    The Oxford Nanopore MinION sequences individual DNA molecules using an array of pores that read nucleotide identities based on ionic current steps. We evaluated and optimized MinION performance using M13 genomic dsDNA. Using expectation-maximization (EM) we obtained robust maximum likelihood (ML) estimates for read insertion, deletion and substitution error rates (4.9%, 7.8%, and 5.1% respectively). We found that 99% of high-quality ‘2D’ MinION reads mapped to reference at a mean identity of 85%. We present a MinION-tailored tool for single nucleotide variant (SNV) detection that uses ML parameter estimates and marginalization over many possible read alignments to achieve precision and recall of up to 99%. By pairing our high-confidence alignment strategy with long MinION reads, we resolved the copy number for a cancer/testis gene family (CT47) within an unresolved region of human chromosome Xq24. PMID:25686389

  16. 43 CFR 3109.1-1 - Generally.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Generally. 3109.1-1 Section 3109.1-1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Leasing Under Special Acts § 3109.1-1 Generally. The Act of May 21, 1930 (30 U.S.C. 301-306), authorizes either the leasing of oil...

  17. 43 CFR 3109.1-1 - Generally.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Generally. 3109.1-1 Section 3109.1-1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Leasing Under Special Acts § 3109.1-1 Generally. The Act of May 21, 1930 (30 U.S.C. 301-306), authorizes either the leasing of oil...

  18. 43 CFR 3109.1-1 - Generally.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Generally. 3109.1-1 Section 3109.1-1..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING Leasing Under Special Acts § 3109.1-1 Generally. The Act of May 21, 1930 (30 U.S.C. 301-306), authorizes either the leasing of oil...

  19. Oral Reading Fluency: Accuracy of Assessing Errors and Classification of Readers Using a 1-Min Timed Reading Sample

    ERIC Educational Resources Information Center

    Coulter, Gail; Shavin, Karen; Gichuru, Margaret

    2009-01-01

    Children in general education are classified by measures of oral reading fluency (ORF) to determine the level of support needed for reading. In addition, teachers use ORF measures with children who receive special education services to determine whether they are making progress toward their reading goals. In this descriptive study, the authors…

  20. [Local fractal analysis of noise-like time series by all permutations method for 1-115 min periods].

    PubMed

    Panchelyuga, V A; Panchelyuga, M S

    2015-01-01

    Results of local fractal analysis of 329-per-day time series of 239Pu alpha-decay rate fluctuations by means of all permutations method (APM) are presented. The APM-analysis reveals in the time series some steady frequency set. The coincidence of the frequency set with the Earth natural oscillations was demonstrated. A short review of works by different authors who analyzed the time series of fluctuations in processes of different nature is given. We have shown that the periods observed in those works correspond to the periods revealed in our study. It points to a common mechanism of the phenomenon observed. PMID:26016038

  1. Acid-promoted transformations of 1-(diphenylphosphoryl)allenes: synthesis of novel 1,4-dihydrophosphinoline 1-oxides.

    PubMed

    Bogachenkov, Alexander S; Dogadina, Albina V; Boyarskiy, Vadim P; Vasilyev, Aleksander V

    2015-02-01

    1-(Diphenylphosphoryl)alka-1,2-dienes (phosphonoallenes) in Brønsted (super)acids (TfOH, FSO3H, and H2SO4) at -70 to 120 °C for 30 min to 4 h gave, at first, (3-hydroxyalk-1-en-1-yl)diphenylphosphine oxides, as kinetically favorable reaction products, that are further converted into 1-phenyl-1,4-dihydrophosphinoline 1-oxides as thermodynamically stable compounds. The latter compounds are formed from phosphonoallenes under the action of a strong Lewis acid AlCl3 at room temperature for 10-120 min. This is a novel, simple and efficient (short reaction time, high yields) method for synthesis of such 1,4-dihydrophosphinoline 1-oxides. PMID:25526497

  2. 48 CFR 1.603-1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.603-1 General... procurement career management program and a system for the selection, appointment, and termination...

  3. 2016 SPD: Day 1

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-06-01

    Editors note: This week were in Boulder, Colorado at the 47th meeting of the AAS Solar Physics Division (SPD). Follow along to catch some of the latest news from the field of solar physics!The 2016 SPD meeting was launched this morning from the University of Colorado Boulder campus. Two of the hot topics at this years meeting include celebration of the recent move of the National Solar Observatorys headquarters to Boulder, and discussion of the future Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST). DKIST, planned for a 2019 completion in Hawaii, is the next big telescope on the horizon for solar physics.Todays press conference had an interesting focus: instruments providing new high-energy observations of the Sun. Representatives from four different instruments were here to talk about some of the latest X-ray solar observations.GRIPSThe GRIPS payload flew at 130,000 ft over Antarctica on a giant balloon in January 2016. [NASA/Albert Shih]First up, Albert Shih (NASA Goddard) described the Gamma-Ray Imager/Polarimeter for Solar flares, or GRIPS. GRIPS is a balloon-borne instrument designed to detect X-rays and gamma rays emitted during solar flares. Up to tens of a percent of the energy in solar flares is emitted in the form of accelerated particles, but the physics behind this process is not well understood. GRIPS observes where the highest-energy particles are accelerated, in an effort to learn more about the process.GRIPS was launched on 19 January, 2016 and flew for roughly 12 days gathering ~1 million seconds of data! The logistics of this instruments flight are especially interesting, since it was launched from Antarctica and carried by a balloon at a whopping elevation of 130,000 ft (to get high enough that the atmosphere doesnt absorb all the photons GRIPS is trying to observe). Though the data from the mission has been retrieved, the bulk of the hardware remains where it landed at the end of January. It must

  4. Pharmacogenetics of SULT1A1

    PubMed Central

    Daniels, Jaclyn; Kadlubar, Susan

    2015-01-01

    Cytosolic SULT1A1 participates in the bioconversion of a plethora of endogenous and xenobiotic substances. Genetic variation in this important enzyme such as SNPs can vary by ethnicity and have functional consequences on its activity. Most SULT1A1 genetic variability studies have been centered on the SULT1A1*1/2 SNP. Highlighted here are not only this SNP, but other genetic variants associated with SULT1A1 that could modify drug efficacy and xenobiotic metabolism. Some studies have investigated how differential metabolism of xenobiotic substances influences susceptibility to or protection from cancer in multiple sites. This review will focus primarily on the impact of SULT1A1 genetic variation on the response to anticancer therapeutic agents and subsequently how it relates to environmental and dietary exposure to both cancer-causing and cancer-preventative compounds. PMID:25493573

  5. TRAM1 Promotes Microglia M1 Polarization.

    PubMed

    Wang, Hanxiang; Liu, Chun; Han, Ming; Cheng, Chun; Zhang, Dongmei

    2016-02-01

    Microglia, the major immune cells of the central nervous system (CNS), can be driven to adopt M1 and M2 phenotypes. Recently, the distinct functions of M1 and M2 microglia have been intensively studied. M1-activation microglia are pro-inflammatory and may contribute to the development of several CSN disorders, while M2-activation microglia are anti-inflammatory and may promote tissue reconstruction. TRAM1 is a protein involved in translocation of nascent polypeptides and functions as a sorting adaptor of TLR4. Here, we found that TRAM1 plays an important role in microglia M1 polarization. Our results showed that the expression of TRAM1 is highly induced in LPS/interferon (IFN)-γ-stimulated BV2 cells and primary microglia cells. Flag-TRAM1 transfection, but not Flag-GFP used as a control, significantly enhanced M1 polarization by strongly increasing expression of M1 makers, such as IL-6, IL-1β, iNOS, and so on. Silence of TRAM1 effectively inhibited LPS/IFN-γ-induced expression of M1-related genes in BV2 cells. In addition, TRAM1 was found to cooperate with TLR4 to induce an M1 genetic program in Flag-TRAM1-transfected and LPS/IFN-γ-induced BV2 cells. TRAM1 is essential for LPS/IFN-γ induced expressions of adapter molecule (IRAK1, phosphorylation of TBK1, and IRF3) of TLR4. TRAM1 is also essential for phosphorylation of IκB and P65 and for P65-NF-kB translocation to nucleus. Overall, our findings showed that TRAM1 could promote microglia M1 polarization. PMID:26563450

  6. Inhibited 1,1,1-trichloroethane replaces trichloroethylene for degreasing

    NASA Technical Reports Server (NTRS)

    Schuler, F. T.

    1970-01-01

    In fight against air pollution inhibited TCE /1,1,1-trichloroethane/ is effective substitute for trichloroethylene in degreasing plants. This chemical has only slight photochemical activity and causes little eye irritation. TCE is less toxic than trichloroethylene and can withstand production loads and conditions, or long term storage, without degradation.

  7. Variant Humicola grisea CBH1.1

    SciTech Connect

    Goedegeburr, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2013-02-19

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  8. Variant Humicola grisea CBH1.1

    SciTech Connect

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2014-03-18

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  9. Variant humicola grisea CBH1.1

    SciTech Connect

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Edmund, Larenas

    2014-09-09

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  10. 43 CFR 2812.1-1 - Filing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Filing. 2812.1-1 Section 2812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) TRAMROADS AND LOGGING ROADS Over O. and C. and...

  11. H1N1 influenza (Swine flu)

    MedlinePlus

    Swine flu; H1N1 type A influenza ... of the H1N1 virus were found in pigs (swine). Over time, the virus changed (mutated) and infected ... 25654610 . Treanor JJ. Influenza (including avian influenza and swine influenza). In: Bennett JE, Dolin R, Blaser MJ, ...

  12. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2011-08-16

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  13. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2011-05-31

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  14. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2008-12-02

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  15. Variant Humicola grisea CBH1.1

    DOEpatents

    Goedegebuur, Frits; Gualfetti, Peter; Mitchinson, Colin; Larenas, Edmund

    2012-08-07

    Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

  16. Get Ready for 1:1

    ERIC Educational Resources Information Center

    Moore, Darcy

    2009-01-01

    Good planning can make or break a successful 1:1 program. The author, a long-time deputy principal with extensive EdTech experience, shares his insights on how to get the most out of 1:1. Read these tips before getting started or improving an existing program.

  17. 43 CFR 9185.1-1 - Surveys.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Surveys. 9185.1-1 Section 9185.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) CADASTRAL SURVEY Instructions and Methods §...

  18. Analytic cross sections for 1 1S, to 1 1S to 2 1S, 1 1S to 2 1P transitions in helium by electron impact

    NASA Technical Reports Server (NTRS)

    Sukumar, C. V.; Faisal, F. H. M.

    1971-01-01

    The 1 1s yields 1 1s elastic and 1 1s yields 2 1s and 1 1s yields 2 excitation cross sections of Helium atoms by collision with a charged particle are obtained as analytic functions of incident velocity. The first order time dependent scattering theory is used. Numerical values of electron -He cross sections are obtained for incident energies in the range 30 eV to 800 eV and compared with earlier Born approximation calculations and with available experimental data. It is found that at 100 eV and above, the present results are in good agreement with the experimental results. They are also closer to the experimental results than the corresponding Born calculations.

  19. Alpha-1 Antitrypsin Deficiency

    MedlinePlus

    ... Liver Disease Information > Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Explore this section to learn more about alpha-1 antitrypsin deficiency, including a description of the disorder ...

  20. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... perform a function under the Act and the regulations in 9 CFR parts 1, 2, and 3. Attending veterinarian... the regulations in 9 CFR parts 1, 2, and 3. Institutional official means the individual at a research... CFR parts 1, 2, and 3 will be met. Isolation in regard to marine mammals means the physical...

  1. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... perform a function under the Act and the regulations in 9 CFR parts 1, 2, and 3. Attending veterinarian... the regulations in 9 CFR parts 1, 2, and 3. Institutional official means the individual at a research... CFR parts 1, 2, and 3 will be met. Isolation in regard to marine mammals means the physical...

  2. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... perform a function under the Act and the regulations in 9 CFR parts 1, 2, and 3. Attending veterinarian... the regulations in 9 CFR parts 1, 2, and 3. Institutional official means the individual at a research... CFR parts 1, 2, and 3 will be met. Isolation in regard to marine mammals means the physical...

  3. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... perform a function under the Act and the regulations in 9 CFR parts 1, 2, and 3. Attending veterinarian... the regulations in 9 CFR parts 1, 2, and 3. Institutional official means the individual at a research... CFR parts 1, 2, and 3 will be met. Isolation in regard to marine mammals means the physical...

  4. 9 CFR 1.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... perform a function under the Act and the regulations in 9 CFR parts 1, 2, and 3. Attending veterinarian... the regulations in 9 CFR parts 1, 2, and 3. Institutional official means the individual at a research... CFR parts 1, 2, and 3 will be met. Isolation in regard to marine mammals means the physical...

  5. Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes.

    PubMed

    Choi, Min-Koo; Kim, Min-Hye; Maeng, Han-Joo; Song, Im-Sook

    2015-01-01

    The objective of this study was to investigate the contributions of a sodium-dependent concentrative nucleoside transporter (CNT) 1 and an equilibrative nucleoside transporter (ENT) 1 to ribavirin uptake in human hepatocytes. The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake, indicating that ribavirin was a substrate for both CNT1 and ENT1. The CNT1- and ENT1-mediated ribavirin uptake showed concentration dependency with the following kinetics parameters: Km 26.3 μM and Vmax 426.2 fmol/min/oocyte for CNT1; Km 70.5 μM and Vmax 134.3 fmol/min/oocyte for ENT1. Ribavirin uptake clearance in six human hepatocytes ranged from 21.3 to 300.7 μL/min. Estimation of the contributions of CNT1 and ENT1 to the hepatic uptake of ribavirin by using a relative activity factor method indicated that the relative contribution of ENT1 to the ribavirin uptake was 82.8 ± 3.9%. Real-time polymerase chain reaction analysis of CNT1 and ENT1 expressions in the hepatocytes showed that ENT1 mRNA expression was closely correlated with ribavirin uptake (R = 0.95, P = 0.003) while CNT1 was not. The findings indicated that ENT1 was the major transporter controlling the hepatic uptake of ribavirin. PMID:25011570

  6. From 1:1 to 1 to Won

    ERIC Educational Resources Information Center

    Hall, Don

    2006-01-01

    In this article, the author discusses on the emphasis of how 1:1 computing program transforms classroom and education experience for students. Moreover, the author stresses that with this type of program, they have created vision where the culture, curriculum, and chores were designed to meet the needs of the digital age students in terms of rigor…

  7. PD-1/PD-L1 inhibitors.

    PubMed

    Sunshine, Joel; Taube, Janis M

    2015-08-01

    Tumors may adopt normal physiologic checkpoints for immunomodulation leading to an imbalance between tumor growth and host surveillance. Antibodies targeting the PD-1/PD-L1 checkpoint have shown dynamic and durable tumor regressions, suggesting a rebalancing of the host-tumor interaction. Nivolumab and pembrolizumab are the anti-PD-1 antibodies that are currently the furthest in clinical development, and anti-PD-L1 agents under investigation include MPDL3280A, MEDI4736, and BMS-936559. These agents have been used to treat advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancer and Hodgkin lymphoma, amongst other tumor types. In this article, we review the updated response results for early clinical trials, note recent FDA actions regarding this class of agents, and summarize results across trials looking at PD-L1 status as a predictor of response to anti-PD-1/PD-L1. PMID:26047524

  8. Min and Max Extreme Interval Values

    ERIC Educational Resources Information Center

    Jance, Marsha L.; Thomopoulos, Nick T.

    2011-01-01

    The paper shows how to find the min and max extreme interval values for the exponential and triangular distributions from the min and max uniform extreme interval values. Tables are provided to show the min and max extreme interval values for the uniform, exponential, and triangular distributions for different probabilities and observation sizes.

  9. Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1.

    PubMed

    Lee, Daniel; Perez, Pedro; Jackson, William; Chin, Taylor; Galbreath, Michael; Fronczek, Frank R; Isovitsch, Ralph; Iimoto, Devin S

    2016-07-15

    Many cytochrome P450 1A1 and 1B1 (CYP1A1 and CYP1B1) inhibitors, such as resveratrol, have planar, hydrophobic, aromatic rings in their structure and exhibit anti-cancer activity. Aryl morpholino triazenes have similar structural features and in addition contain a triazene unit consisting of three consecutive, conjugated nitrogen atoms. Several aryl morpholino triazenes, including 4-[(E)-2-(3,4,5-trimethoxyphenyl)diazenyl]-morpholine (2), were prepared from a reaction involving morpholine and a diazonium ion produced from different aniline derivatives, such as 3,4,5-trimethoxyaniline. The aryl morpholino triazenes were then screened at 100μM for their ability to inhibit CYP1A1 and CYP1B1 using ethoxyresorufin as the substrate. Triazenes that inhibited the enzymes to less than 80% of the uninhibited enzyme activity were assayed to determine their IC50 value. Compound 2 was the only triazene to inhibit both CYP1A1 and CYP1B1 to the same degree as resveratrol with IC50 values of 10μM and 18μM, respectively. Compounds 3 and 6 selectively inhibited CYP1B1 over CYP1A1 with IC values of 2μM and 7μM, respectively. Thus, aryl morpholino triazenes are a new class of compounds that can inhibit CYP1A1 and CYP1B1 and potentially prevent cancer. PMID:27265259

  10. Acetylene, a mammalian metabolite of 1,1,1-trichloroethane.

    PubMed

    Dürk, H; Poyer, J L; Klessen, C; Frank, H

    1992-09-01

    1,1,1-Trichloroethane (TCE) is a widely used industrial solvent of low acute toxicity. It is slowly oxidized to trichloroethanol and trichloroacetic acid by cytochrome P-450-dependent mono-oxygenases. Increased inhalative uptake by rats under hypoxia and spin-trapping experiments indicate that TCE is also reductively metabolized to a radical intermediate. Acetylene is formed as a metabolite, suggesting transfer of an additional electron to form the corresponding carbene. Hypoxia and induction of mixed-function mono-oxygenases accelerate the formation of acetylene. Experiments performed in vitro with rat liver microsomal fractions yield analogous results. PMID:1326938

  11. SealSim Version 1.1

    2005-05-16

    SealSim 1.1 is a state-of-the-art, Microsoft Windows based computer program developed for the U.S. Department of Energy by Aspen Research Corporation with Contracted support from TNO TPD. It is intended to be used by manufacturers, engineers, educators, students, architects, and others to help determine the relative durability of Insulating Glass Units (IGU). As a function of time, SealSim 1.1 simulates the behaviour of an Insulating Glass Unit, exposed to realistic or user-defined weather climates. Stressesmore » and strains in the IGU are calculated as a function of time, together with temperature distributions, gas permeation effects (gas loss, desiccant loading), dew point temperature, U-factor, etc. The current version of SealSim 1.1 supports double-glazing Units. where the spacer system is either a Thermo Plastic Spacer (TPS) or Box type spacer. For the determination of solar properties of glazing systems, SealSim 1.1 uses the Tntemational Glazing Database of LBNL, which is also used by OPTICS and WINDOW. The goal of the SealSim 1.1 simulations is to predict the IGU’s average lifetime, expressed in terms of the "Durability Index", together with the associated failure mechanisms. The Durability Index of a particular IGU and its most probable failure mechanism can be compared with other IGU’s. How the predicted Durability Index relates to the actual durability of an IGU is not known, simply because sufficient experimental data is lacking for describing the behaviour of IG Units over extended periods of time together with a lack of knowledge of the conditions it is subjected to and initial state of the CU at the time of manufacturing. In order to simulate the IGU behaviour in time, the conditions of the IGU must be defined; together with the weather and or climate that the IGU is subjected to. Using physical models of the IGU, SealSim 1.1 calculates tte response of the CU in time. These physical models are described in more detail in separate documents

  12. Interleukin-1β induces the upregulation of caveolin-1 expression in a rat brain tumor model

    PubMed Central

    QIN, LI-JUAN; JIA, YONG-SEN; ZHANG, YI-BING; WANG, YIN-HUAN

    2016-01-01

    The aim of the present study was to investigate the expression of caveolin-1 in rat brain glioma tissue, and to determine whether interleukin-1β (IL-1β) has a role in this process. Using glioma cells, a tumor-burdened rat model was established, and the expression of caveolin-1 protein in the tumor sites was significantly increased following intracarotid infusion of IL-1β (3.7 ng/kg/min), as indicated by western blot analysis. The maximum value of the caveolin-1 expression was observed in tumor-burdened rats after 60 min of IL-1β perfusion, and which was significantly enhanced by vascular endothelial growth factor (VEGF). In addition, VEGF also significantly increased IL-1β-induced blood tumor barrier (BTB) permeability. The results suggest that the IL-1β-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process. PMID:27073627

  13. Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.

    PubMed

    Fujimoto, Kyoko; Fujii, Gen; Sakurai, Hitomi; Yoshitome, Hiroko; Mutoh, Michihiro; Wada, Morimasa

    2015-01-01

    Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestinal polyps in Apc (Min/+) mice, which are a useful model to clarify the role of Peyer's patches in intestinal tumorigenesis. Using this model, we increased the number of Peyer's patches using 0.1% and 1% corn husk arabinoxylan through feed. Intestinal polyp formation significantly decreased, concomitant with an increase in Peyer's patches development (n = 12/group). In Aly (-/-) Apc (Min/+) mice (negative control; no Peyer's patches) there was no change in the amount of intestinal polyps (n = 10/group). Immune reaction following corn husk arabinoxylan treatment was measured by cytokine array. Increasing the number of Peyer's patches decreased interleukin-17 production, which showed a dose dependent correlation with transcription factor/lymphoid enhancer-binding factor. This study identified a relationship between levels of Peyer's patches and intestinal polyp formation, partly explained by the involvement of interleukin-17 production and β-catenin signaling in Apc (Min/+) mice. PMID:25678750

  14. Nucleobindin-1 encodes a nesfatin-1-like peptide that stimulates insulin secretion.

    PubMed

    Ramesh, Naresh; Mohan, Haneesha; Unniappan, Suraj

    2015-05-15

    Nesfatin-1 (82 amino acid) is an anorexigenic and insulinotropic peptide encoded in a secreted precursor, nucleobindin-2 (NUCB2). Nucleobindin-1 (NUCB1) is a protein with very high sequence similarity to NUCB2. We hypothesized that a nesfatin-1 like peptide (NLP) is encoded in NUCB1, and this peptide is biologically active. In silico analysis found a signal peptide cleavage site at position 25 (Arginine) and 26 (Valine) preceding the NLP region in NUCB1 sequence, and potential proprotein convertase cleavage sites at Lys-Arg (KR), forming a 77 amino acid NLP. RT-PCR studies found NUCB1 mRNA in both pancreas and MIN6 cells. NUCB1-like immunoreactivity was detected in mouse insulinoma (MIN6) cells, and pancreatic islet beta cells of mice. In order to determine the biological activity of NLP, MIN6 cells were incubated with synthetic rat NLP. NLP (10nM and 100nM) upregulated preproinsulin mRNA expression and insulin secretion at 1h post-incubation. In identical experiments using MIN6 cells, a scrambled peptide based on the NLP sequence did not elicit any effects on preproinsulin mRNA expression or insulin secretion. From this result, it is clear that an intact NLP sequence is required for its biological activity. NLP appears as another endogenous insulinotropic peptide encoded in NUCB1. PMID:25907657

  15. Growth of monocrystalline Cu(1 1 1) films on MgO(1 1 1) by pulsed laser deposition

    NASA Astrophysics Data System (ADS)

    Aweke, F.; Antoni, F.; Hulik, J.; Morvan, G.; Speisser, C.; Veis, P.; Le Normand, F.

    2015-05-01

    Copper (Cu) films with a minimal thickness of 300 nm were grown on MgO(1 1 1) substrates in high vacuum by pulsed laser deposition (PLD) at various temperatures to achieve a single crystal Cu film with flat terraces without grain boundaries. We investigated the effect of the substrate temperature, the pulse repetition rate, the deposition time and the laser fluence. A temperature threshold is observed above which the growth mode is changed from a uniform flat mode to a three dimensional mode. A combined process involving a germination step at moderate temperature followed by a growth step at higher temperature yields a 450 nm almost continuous film.

  16. 26 CFR 1.1502-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TAXES (CONTINUED) Consolidated Returns § 1.1502-1 Definitions. (a) Group. The term group means an... common parent which is a member of such group. (d) Consolidated return year. The term consolidated return year means a taxable year for which a consolidated return is filed or required to be filed by...

  17. 26 CFR 1.1502-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAXES Consolidated Returns § 1.1502-1 Definitions. (a) Group. The term group means an affiliated group... common parent which is a member of such group. (d) Consolidated return year. The term consolidated return year means a taxable year for which a consolidated return is filed or required to be filed by...

  18. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life insurance company as used in subtitle A of the Code is defined in section 801. For the purpose of determining whether a company is a “life insurance company” within the meaning of that term as used in...

  19. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life insurance company as used in subtitle A of the Code is defined in section 801. For the purpose of determining whether a company is a “life insurance company” within the meaning of that term as used in...

  20. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life insurance company as used in subtitle A of the Code is defined in section 801. For the purpose of determining whether a company is a “life insurance company” within the meaning of that term as used in...

  1. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAXES Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life... determining whether a company is a “life insurance company” within the meaning of that term as used in section... whether an insurance company is a life insurance company, the life insurance reserves (as defined...

  2. 26 CFR 1.801-1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TAXES (CONTINUED) Life Insurance Companies § 1.801-1 Definitions. (a) Life insurance company. The term life insurance company as used in subtitle A of the Code is defined in section 801. For the purpose of determining whether a company is a “life insurance company” within the meaning of that term as used in...

  3. Ciencias 1. (Science 1). [Student's Workbook].

    ERIC Educational Resources Information Center

    Raposo, Lucilia

    Ciencias 1 is the first in a series of science books designed for elementary Portuguese-speaking students. The book contains five sections divided into 43 lessons. The five sections are (1) Matter, (2) The Human Body, (3) Weather, (4) Solids, Liquids, and Gases, and (5) Living Things. Pictorial presentations and picture exercises are included for…

  4. 1,1,2,2-Tetrachloroethane

    Integrated Risk Information System (IRIS)

    1,1,2,2 - Tetrachloroethane ; CASRN 79 - 34 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncar

  5. 33 CFR 1.08-1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) 46 U.S.C. 103, documented yachts; (7) 33 CFR part 155 oil pollution prevention; and (8) 46 CFR 25.30... criminal penalty procedures under subpart 1.07 of this part: (1) 46 CFR 25.05 whistles or other sound producing devices; (2) 33 CFR part 175, subpart B and 46 CFR subpart 25.25, Personal Flotation Devices....

  6. 33 CFR 1.08-1 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) 46 U.S.C. 103, documented yachts; (7) 33 CFR part 155 oil pollution prevention; and (8) 46 CFR 25.30... criminal penalty procedures under subpart 1.07 of this part: (1) 46 CFR 25.05 whistles or other sound producing devices; (2) 33 CFR part 175, subpart B and 46 CFR subpart 25.25, Personal Flotation Devices....

  7. 33 CFR 1.08-1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) 46 U.S.C. 103, documented yachts; (7) 33 CFR part 155 oil pollution prevention; and (8) 46 CFR 25.30... criminal penalty procedures under subpart 1.07 of this part: (1) 46 CFR 25.05 whistles or other sound producing devices; (2) 33 CFR part 175, subpart B and 46 CFR subpart 25.25, Personal Flotation Devices....

  8. 33 CFR 1.08-1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) 46 U.S.C. 103, documented yachts; (7) 33 CFR part 155 oil pollution prevention; and (8) 46 CFR 25.30... criminal penalty procedures under subpart 1.07 of this part: (1) 46 CFR 25.05 whistles or other sound producing devices; (2) 33 CFR part 175, subpart B and 46 CFR subpart 25.25, Personal Flotation Devices....

  9. 43 CFR 3191.1-1 - Petition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) DELEGATION OF AUTHORITY, COOPERATIVE AGREEMENTS AND CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-1 Petition. The Governor or...

  10. Expect Surprises with 1-to-1 Laptops

    ERIC Educational Resources Information Center

    Tusch, Erich G.

    2012-01-01

    In 2004, prior to the launch of their 1-to-1 laptop program, the superintendent expressed some anxiety about the prospect of radically changing teaching and learning by issuing a laptop computer to every student and teacher. Although the concept was exciting, it carried big risks and would take time and thorough planning to execute well. Even with…

  11. General Relativity in (1 + 1) Dimensions

    ERIC Educational Resources Information Center

    Boozer, A. D.

    2008-01-01

    We describe a theory of gravity in (1 + 1) dimensions that can be thought of as a toy model of general relativity. The theory should be a useful pedagogical tool, because it is mathematically much simpler than general relativity but shares much of the same conceptual structure; in particular, it gives a simple illustration of how gravity arises…

  12. Grumman JF-1 Duck

    NASA Technical Reports Server (NTRS)

    1934-01-01

    Grumman JF-1 Duck: The Grumman JF-1 Duck was in service with the NACA at Langley during the summer of 1934. The JF-1 was notably different from the later J2F Duck in that the JF-1 had a shorter central float. The NACA used the JF-1 in part as a propeller testbed aircraft.

  13. Glide of dislocations in <1 1 1>{3 2 1} slip system: an atomistic study

    NASA Astrophysics Data System (ADS)

    Terentyev, D.; Bakaev, A.; Van Neck, D.; Zhurkin, E. E.

    2016-01-01

    Atomistic calculations are performed to investigate plastic slip in the <1 1 1>{3 2 1} system in body-centred cubic iron. Several modern interatomic potentials, developed over the last decade, are applied to compute the stacking fault γ-line energy in the {3 2 1} plane and the results are compared with the ab initio prediction. The applied potentials have shown strong deviations, but several potentials acquired good qualitative agreement with the ab initio data. Depending on the applied potential, the lowest value of the Peierls stress for the edge dislocation (ED) is 50 MPa (Ackland and Bacon from 1997) and the highest is 550 MPa (Dudarev and Derlet from 2005), while for the screw dislocation it is much higher, in the range 1-2 GPa. At finite temperature, however, the flow stress of the ED is found to decrease exponentially reaching a negligible value at about 200 K, irrespective of the applied potential. On the basis of the data obtained using Ackland-Mendelev potential from 2004, we conclude that the slip resistance of the <1 1 1>{3 2 1} system is in between the resistance of the <1 1 1>{1 1 0} and <1 1 1>{1 1 2} slip systems.

  14. [1+1+1] Cyclotrimerization for the Synthesis of Cyclopropanes.

    PubMed

    Manna, Srimanta; Antonchick, Andrey P

    2016-04-18

    The synthesis of small rings by functionalization of C(sp(3) )-H bonds remains a great challenge. We report for the first time a copper-catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives under mild reaction conditions. The reaction has a broad scope for the stereoselective synthesis of cyclopropanes by trimerization of acetophenone. The developed transformation is based on an extraordinary copper-catalyzed cascade process that allows saturated carbocycles to be obtained for the first time by cyclotrimerization through functionalization of C(sp(3) )-H bonds. The cascade of sixfold C(sp(3) )-H bond functionalization allows the synthesis of cyclopropanes in a highly stereoselective approach. PMID:26997466

  15. Vapor-liquid equilibria for 1,1,1,2-tetrafluoroethane + 1-chloro-1,2,2,2-tetrafluoroethane and 1-chloro-1,2,2,2-tetrafluoroethane + 1-chloro-1,1-difluoroethane systems

    SciTech Connect

    Lee, J.; Lee, J.; Kim, H.

    1996-07-01

    Isothermal vapor-liquid equilibria were determined for two binary mixtures of refrigerants with a circulation type apparatus. The 1,1,1,2-tetrafluoroethane (HFC-134a) + 1-chloro-1,2,2,2-tetrafluoroethane (HCFC-124) system was studied at 296.45, 302.25, and 307.25 K. The 1-chloro-1,2,2,2-tetrafluoroethane (HCFC-124) + 1-chloro-1,1-difluoroethane (HCFC-142b) system was studied at 298.15 and 312.15 K. At each temperature, the pressure and vapor and liquid compositions were measured. Results were correlated with the Peng-Robinson equation of state.

  16. Amylase α-1A (AMY1A)

    PubMed Central

    Jain, Sarika; Roy, Somak; Amin, Milon; Acquafondata, Marie; Yin, Ming; LaFramboise, William; Bastacky, Sheldon; Pantanowitz, Liron; Dhir, Rajiv; Parwani, Anil

    2014-01-01

    Chromophobe renal cell carcinoma (ChRCC) and oncocytoma present with a perplexing overlap of morphologic and immunohistochemical features. ChRCC have deletions in the 1p21.1 region including the amylase α-1A gene (AMY1A). No such deletions are found in oncocytoma. Instead, oncocytomas shared other deletions on chromosome 1: 1p31.3, 1q25.2, and 1q44. We performed AMY1A immunostaining on 75 oncocytomas (57 tissue microarray [TMA] cores, 18 whole slides) and 54 ChRCCs (20 TMA cores, 34 whole slides). Staining was assessed using the H-score method. The intensity was graded as follows: no staining=0, weak=1, moderate=2, and strong=3. The AMY1A immunostain preferentially stained the distal tubules and collecting ducts of normal kidney. All oncocytomas (100%) expressed AMY1A with an H-score that varied from 100 to 300 (mean 205). Mild to moderate heterogeneity in staining intensity was noted within a given oncocytoma. For oncocytomas, 87% (65/75) cases had H-scores of at least 120 with a mean score of 221. Notably, the 13% (10/75) of oncocytoma cases that had an H-score of 100 were derived from the TMA. A total of 87% (47/54) of the ChRCC cases were negative for the AMY1A immunostain. Of the ChRCC cases, 4% (2/54) showed very weak cytoplasmic staining (H-score of 70 each), which was less than the lowest H-score of oncocytoma cases. All 5 cases of ChRCC, which showed an H-score of 100 or more, were referred to as eosinophilic variants of ChRCC. Three of these 5 cases showed a very nondescript, diffuse staining of the cytoplasm. Two of these 5 cases showed an H-score of 130. We think that as the staining pattern of these 2 cases is similar to that of oncocytoma, they should be put in a category of renal oncocytic neoplasms favoring oncocytoma. This result shows that AMY1A staining could be very helpful in further classifying even a subset of the eosinophilic variants of ChRCC. The difference between ChRCC and oncocytoma was statistically significant (χ2 test, P<0

  17. Spatial heterogeneity of surface roughness during different erosive stages of tilled loess slopes under a rainfall intensity of 1.5 mm min-1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The loess tilled slope is the main place for soil erosion in Chinese Loess Plateau, and studies about its spatial heterogeneity (SH) of surface roughness (SR) has been one of the most important problems in the field of soil erosion. The objective of this study was to reveal the SH of SR of 4 typical...

  18. Surface waves of Min-proteins

    NASA Astrophysics Data System (ADS)

    Fischer-Friedrich, Elisabeth; Nguyen van yen, Romain; Kruse, Karsten

    2007-03-01

    In the bacterium Escherichia coli, the Min-proteins show pronounced pole-to-pole oscillations. They are functional for suppressing cell division at the cell ends, leaving the center as the only possible site for division. Analyzing different models of Min-protein dynamics in a bacterial geometry, we find waves on the cytoplasmic membrane. Interestingly, the surface wave solutions of different models belong to different symmetry classes. We suggest that experiments on Min-protein surface waves in vitro are helpful in distinguishing between different classes of models of Min-protein dynamics.

  19. Alpha-1 Antitrypsin Deficiency

    MedlinePlus

    ... from the NHLBI on Twitter. What Is Alpha-1 Antitrypsin Deficiency? Alpha-1 antitrypsin (an-tee-TRIP-sin) deficiency, or AAT ... as it relates to lung disease. Overview Alpha-1 antitrypsin, also called AAT, is a protein made ...

  20. IL-1 Blockade in Autoinflammatory Syndromes1

    PubMed Central

    Jesus, Adriana A.; Goldbach-Mansky, Raphaela

    2014-01-01

    Monogenic autoinflammatory syndromes present with excessive systemic inflammation including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in single genes encoding proteins that regulate innate inflammatory pathways. Pathogenic variants in two interleukin-1 (IL-1)–regulating genes, NLRP3 and IL1RN, cause two severe and early-onset autoinflammatory syndromes, CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist). The discovery of the mutations that cause CAPS and DIRA led to clinical and basic research that uncovered the key role of IL-1 in an extended spectrum of immune dysregulatory conditions. NLRP3 encodes cryopyrin, an intracellular “molecular sensor” that forms a multimolecular platform, the NLRP3 inflammasome, which links “danger recognition” to the activation of the proinflammatory cytokine IL-1β. The success and safety profile of drugs targeting IL-1 in the treatment of CAPS and DIRA have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor–associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still’s, Behcet’s, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1β-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. PMID:24422572

  1. SPARK Version 1. 1 user manual

    SciTech Connect

    Weissenburger, D.W.

    1988-01-01

    This manual describes the input required to use Version 1.1 of the SPARK computer code. SPARK 1.1 is a library of FORTRAN main programs and subprograms designed to calculate eddy currents on conducting surfaces where current flow is assumed zero in the direction normal to the surface. Surfaces are modeled with triangular and/or quadrilateral elements. Lorentz forces produced by the interaction of eddy currents with background magnetic fields can be output at element nodes in a form compatible with most structural analysis codes. In addition, magnetic fields due to eddy currents can be determined at points off the surface. Version 1.1 features eddy current streamline plotting with optional hidden-surface-removal graphics and topological enhancements that allow essentially any orientable surface to be modeled. SPARK also has extensive symmetry specification options. In order to make the manual as self-contained as possible, six appendices are included that present summaries of the symmetry options, topological options, coil options and code algorithms, with input and output examples. An edition of SPARK 1.1 is available on the Cray computers at the National Magnetic Fusion Energy Computer Center at Livermore, California. Another more generic edition is operational on the VAX computers at the Princeton Plasma Physics Laboratory and is available on magnetic tape by request. The generic edition requires either the GKS or PLOT10 graphics package and the IMSL or NAG mathematical package. Requests from outside the United States will be subject to applicable federal regulations regarding dissemination of computer programs. 22 refs.

  2. Early cardiology assessment and intervention reduces mortality following myocardial injury after non-cardiac surgery (MINS)

    PubMed Central

    Hua, Alina; Pattenden, Holly; Leung, Maria; Davies, Simon; George, David A.; Raubenheimer, Hilgardt; Niwaz, Zakiyah

    2016-01-01

    Background Myocardial injury after non-cardiac surgery (MINS) is defined as troponin elevation of ≥0.03 ng/mL associated with 3.87-fold increase in early mortality. We sought to determine the impact of cardiology intervention on mortality in patients who developed MINS after general thoracic surgery. Methods A retrospective review was performed in patients over 5 years. Troponin was routinely measured and levels ≥0.04 ng/mL classified as positive. Data acquisition and mortality status was obtained via medical records and NHS tracing systems. Thirty-day mortality was compared on MINS cohort using Fisher’s exact square testing and logistic regression analysis. Results Troponin levels were measured in 491 (96%) of 511 patients. Eighty (16%) patients fulfilled the MINS criteria. Sixty-one (76%) received early cardiology consult and “myocardial infarction” stated in four (5%) patients. Risk assessment (for AMI) was undertaken; 20 (25%) patients were commenced on aspirin, four (5%) on β-blockers and one (1%) underwent percutaneous coronary intervention. Forty-nine (61%) patients received primary risk factor modifications and 26 (33%) had outpatient follow-up. There were no significant differences in the proportion of patients who died within 30 days post-operatively in the MINS group of 2.6% compared to the non-MINS group of 1.6% (P=0.625). The odds ratio for 30-day mortality in the MINS group was 1.69 (95% CI: 0.34 to 8.57, P=0.522). Conclusions MINS is common after general thoracic surgery. Early cardiology intervention reduced the expected hazard ratio of early death from 3.87 to an odds ratio of 1.69 with no significant difference in 30-day mortality for patients who developed MINS. PMID:27162667

  3. Bacterial cell division: a moving MinE sweeper boggles the MinD.

    PubMed

    Margolin, W

    2001-05-15

    Placement of the division site in Escherichia coli is determined in part by three Min proteins. Recent studies have shown that MinE, previously thought to form a static ring near the division site at the midcell position, actually joins MinC and MinD in their rapid oscillation between the cell poles. PMID:11378404

  4. Geometric modeling of homoepitaxial CVD diamond growth: I. The {1 0 0}{1 1 1}{1 1 0}{1 1 3} system

    NASA Astrophysics Data System (ADS)

    Silva, F.; Bonnin, X.; Achard, J.; Brinza, O.; Michau, A.; Gicquel, A.

    2008-01-01

    Plasma-assisted CVD homoepitaxial diamond growth is a process that must satisfy many stringent requirements to meet industrial applications, particularly in high-power electronics. Purity control and crystalline quality of the obtained samples are of paramount importance and their optimization is a subject of active research. In the process of such studies, we have obtained high purity CVD diamond monocrystals with unusual morphologies, namely with apparent {1 1 3} stable faces. This phenomenon has led us to examine the process of CVD diamond growth and build up a 3D geometrical model, presented here, describing the film growth as a function of time. The model has been able to successfully describe the morphology of our obtained crystals and can be used as a predictive tool to predetermine the shape and size of a diamond crystal grown in a given process configuration. This renders accessible control of desirable properties such as largest usable diamond surface area and/or film thickness, before the cutting and polishing manufacture steps take place. The two latter steps are more sensitive to the geometry of the growth sectors, which will be addressed in a companion paper. Our model, applicable to the growth of any cubic lattice material, establishes a complete mapping of the final morphology state of growing diamond, as a function of the growth rates of the crystalline planes considered, namely {1 0 0}, {1 1 1}, {1 1 0}, and {1 1 3} planes, all of which have been observed experimentally in diamond films. The model makes no claim as to the stability of the obtained faces, such as the occurrence of non-epitaxial crystallites or twinning. It is also possible to deduce transient behavior of the crystal morphology as growth time is increased. The model conclusions are presented in the form of a series of diagrams, which trace the existence (and dominance) boundaries of each face type, in presence of the others, and where each boundary crossing represent a topology

  5. Adsorption and reaction of methanethiol on Pt(1 1 1)

    NASA Astrophysics Data System (ADS)

    Lin, T. H.; Huang, T. P.; Liu, Y. L.; Yeh, C. C.; Lai, Y. H.; Hung, W. H.

    2005-03-01

    Adsorption and thermal decomposition of H 3CSH on Pt(1 1 1) is studied with temperature-programmed desorption (TPD) and X-ray photoelectron spectroscopy (XPS) with synchrotron radiation. A H 3CSH molecule undergoes dehydrogenation via formation of H xCS ( x ⩽ 3) intermediates. The catalytic reactivity of Pt for dehydrogenation, which depends on interaction between the surface and the CH x moiety of H xCS, varies with coverage. At large coverage, H 3CSH decomposes through desorbing hydrogen via stepwise dehydrogenation (H 3CS → H 2CS → HCS → S + C). H 2CS is proposed to be an intermediate for dehydrogenation of H 3CS below 240 K, and subsequently undergoes disproportionation to form HCS with desorption of CH 4 at 400 K. The HCS species further decomposes to desorb hydrogen at 475 K and to form C and S adatoms; these adatoms show a mixed (√{3}×√{3})R30° and dim c(2 × 2) LEED pattern at saturation exposure. At small coverage, surface Pt exhibits a catalytic effect on dehydrogenation of H xCS via interaction of the CH x moiety with surface Pt atoms. Dehydrogenation of H 3CSH is completed below 370 K and is proposed to form a surface C sbnd S species; this species entirely decomposes to form C and S adatoms at 570 K.

  6. Cold Sores (HSV-1)

    MedlinePlus

    ... Help a Friend Who Cuts? Cold Sores (HSV-1) KidsHealth > For Teens > Cold Sores (HSV-1) Print A A A Text Size What's in ... person's lips, are caused by herpes simplex virus-1 (HSV-1) . But they don't just show ...

  7. Communication Skills 1, Weekly Log Summary, Revision 1 (CS-1-WLSR1).

    ERIC Educational Resources Information Center

    Wolfe, Howard; Foote, Thomas

    Computer routines to summarize data and generate reports from weekly log records submitted by teachers participating in the Southwest Regional Laboratory's communications skills monitoring program are described. Written in Univac FORTRAN V, Communications Skills 1, Weekly Log Summary, Revision 1 (CS-1-WLSR1) displays information by student group,…

  8. Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine.

    PubMed

    Goh, Yi Ling; Adsool, Vikrant A

    2015-12-28

    Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination. PMID:26553141

  9. Entanglement tsunami in (1 +1 )-dimensions

    NASA Astrophysics Data System (ADS)

    Leichenauer, Stefan; Moosa, Mudassir

    2015-12-01

    We study the time dependence of the entanglement entropy of disjoint intervals following a global quantum quench in (1 +1 )-dimensional CFTs at large c with a sparse spectrum. The result agrees with a holographic calculation but differs from the free field theory answer. In particular, a simple model of free quasiparticle propagation is not adequate for CFTs with a holographic dual. We elaborate on the entanglement tsunami proposal of Liu and Suh and show how it can be used to reproduce the holographic answer.

  10. [Interleukin-1-mediated diseases].

    PubMed

    Holzinger, D; Becker, H; Jacobi, A M

    2013-04-01

    Interleukin-1 (IL-1)-mediated diseases are caused by an inappropriately high production and release of IL-1 beta which results in a multitude of symptoms, e.g. arthritis, exanthema, conjunctivitis, serositis, fever and loss of hearing. If IL-1-mediated diseases remain unrecognized or are recognized and treated too late, long-term complications, such as amyloidosis may occur. In recent years the diagnostic and therapeutic options with respect to IL-1-mediated diseases have drastically improved. These diseases often manifesting in childhood can now be treated with monoclonal antibodies against IL-1 or with IL-1 receptor antagonists. Increased IL-1 secretion does not only play a role in relatively rare hereditary diseases, such as cryopyrin-associated periodic fever syndromes or familial Mediterranean fever but also in widespread diseases, such as gout or type 2 diabetes. This article will focus on pathogenic, diagnostic and therapeutic aspects of IL-1-mediated inflammatory diseases. PMID:23460390

  11. 26 CFR 1.306-1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... following examples: Example 1. On December 15, 1954, A and B owned equally all of the stock of Corporation X which files its income tax return on a calendar year basis. On that date Corporation X distributed pro... of Corporation X were $20,000. The 50 shares of preferred stock so distributed to A had an...

  12. 26 CFR 1.306-1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... following examples: Example 1. On December 15, 1954, A and B owned equally all of the stock of Corporation X which files its income tax return on a calendar year basis. On that date Corporation X distributed pro... of Corporation X were $20,000. The 50 shares of preferred stock so distributed to A had an...

  13. 26 CFR 1.150-1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Treasury pursuant to the Demand Deposit State and Local Government Series program described in 31 CFR part...; trustee fees; paying agent fees; bond registrar, certification, and authentication fees; accounting fees... arbitrage device under § 1.148-10(a) or a device to avoid other limitations in sections 103 and 141...

  14. 26 CFR 1.150-1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Local Government Series program described in 31 CFR part 344. Working capital expenditure means any cost... the definition of bond documents contained in paragraph (b) of this section and the effective date of... the definition of placed in service under § 1.150-2(c)) under general Federal income tax...

  15. 43 CFR 8365.1-1 - Sanitation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Whenever practicable, visitors shall pack their trash for disposal at home. (b) On all public lands, no person shall, unless otherwise authorized: (1) Dispose of any cans, bottles and other nonflammable trash and garbage except in designated places or receptacles; (2) Dispose of flammable trash or...

  16. Unified Modern Mathematics, Course 1, Part 1.

    ERIC Educational Resources Information Center

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    This is Part 1 of the first course in a series which focuses on building fundamental mathematical structures. The arithmetic studied in elementary school along with modular arithmetic is examined and set notation and mappings of sets are presented. Mathematical group structures are introduced. Points and numbers are related both on a line and in a…

  17. 26 CFR 1.316-1 - Dividends.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... distributee for such year. For purposes of section 333(e)(1), a shareholder's ratable share of the earnings... constitutes a “deficiency dividend” as defined in section 860(f). (e) The application of section 316 may be....S.C. 860(l)); sec. 860(g) (92 Stat. 2850, 26 U.S.C. 860(g)); and sec. 7805 (68A Stat. 917, 26...

  18. Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafluoropropane) following whole-body exposure.

    PubMed

    Emmen, H H; Hoogendijk, E M; Klöpping-Ketelaars, W A; Muijser, H; Duistermaat, E; Ravensberg, J C; Alexander, D J; Borkhataria, D; Rusch, G M; Schmit, B

    2000-08-01

    HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafluoropropane) are used to replace chlorofluorocarbons (CFCs) in refrigerant and aerosol applications, including medical use in metered-dose inhalers. Production and consumption of CFCs are being phased out under the Montreal Protocol on Substances that Deplete the Ozone Layer. The safety and pharmacokinetics of HFC 134a and HFC 227 were assessed in two separate double-blind studies. Each HFC (hydrofluorocarbon) was administered via whole-body exposure as a vapor to eight (four male and four female) healthy volunteers. Volunteers were exposed, once weekly for 1 h, first to air and then to ascending concentrations of HFC (1000, 2000, 4000, and 8000 parts per million (ppm)), interspersed with a second air exposure and two CFC 12 (dichlorodifluoromethane) exposures (1000 and 4000 ppm). Comparison of either HFC 134a or HFC 227 to CFC 12 or air gave no clinically significant results for any of the measured laboratory parameters. There were no notable adverse events, there was no evidence of effects on the central nervous system, and there were no symptoms of upper respiratory tract irritation. HFC 134a, HFC 227, and CFC 12 blood concentrations increased rapidly and in an exposure-concentration-dependent manner, although not strictly proportionally, and approached steady state. Maximum blood concentrations (C(max)) tended to be higher in males than females; in the HFC 227 study, these were statistically significantly (P < 0. 05) higher in males for each HFC 227 and CFC 12 exposure level. In the HFC 134a study, the gender difference in C(max) was only statistically significant (P < 0.05) for CFC 12 at 4000 ppm and HFC 134a at 8000 ppm. Following the end of exposure, blood concentrations declined rapidly, predominantly biphasically and independent of exposure concentration. For the HFC 134a study, the t(1/2)alpha (alpha elimination half-life) was short for both CFC 12 and HFC 134a (<11 min). The t(1

  19. Min-protein oscillations in round bacteria

    NASA Astrophysics Data System (ADS)

    Huang, Kerwyn Casey; Wingreen, Ned S.

    2004-12-01

    In rod-shaped Escherichia coli cells, the Min proteins, which are involved in division-site selection, oscillate from pole-to-pole. The homologs of the Min proteins from the round bacterium Neisseria gonorrhoeae also form a spatial oscillator when expressed in wild-type and round, rodA- mutants of E. coli, suggesting that the Min proteins form an oscillator in N. gonorrhoeae. Here we report that a numerical model for Min-protein oscillations in rod-shaped cells also produces oscillations in round cells (cocci). Our numerical results explain why the MinE-protein rings found in wild-type E. coli are absent in round mutants. In addition, we find that for round cells there is a minimum radius below which oscillations do not occur, and a maximum radius above which oscillations become mislocalized. Finally, we demonstrate that Min-protein oscillations can select the long axis in nearly round cells based solely on geometry, a potentially important factor in division-plane selection in cocci.

  20. Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure.

    PubMed

    Gunnare, Sara; Ernstgård, Lena; Sjögren, Bengt; Johanson, Gunnar

    2006-11-01

    The aim of this study was to determine the uptake and disposition of inhaled 1,1,1,2-tetrafluoroethane (HFC-134a) in humans. Ten male volunteers were exposed to 500 ppm HFC-134a (2 h, 50 W exercise). The HFC-134a levels were monitored in blood, exhaled air and urine up to 19 h post-exposure. The concentration in blood increased rapidly, reaching a plateau of 9.4+/-1.9 microM (mean+/-S.D.) within 30 min, followed by a fast post-exposure decrease. HFC-134a in expired air decreased rapidly as well and in parallel with that in blood. The post-exposure urinary excretion was 0.002% of the inhaled amount, and the half-time was 58 min (pooled data). A physiologically based toxicokinetic (PBTK) model was developed for further analysis. Experimental and simulated time courses in blood and exhaled air agreed well in all 10 subjects. Further, the late decay in blood was consistent with a wash-out of HFC-134a from fat tissues, with a half-time of 114+/-21 min. The simulated relative uptake during exposure was 3.7+/-0.5%. No remarkable findings were observed in the electrocardiographic recordings. Fibrinogen in plasma increased 1 day after exposure, whereas no effects on C-reactive protein, serum amyloid A protein, D-dimer or uric acid were seen. Further studies are needed to investigate the possible inflammatory response. PMID:17030466

  1. Alpha-1 Antitrypsin Test

    MedlinePlus

    ... measures the level of the protein AAT in blood. Alpha-1 antitrypsin phenotype testing evaluates the amount and type of AAT being produced and compares it to normal patterns. Alpha-1 antitrypsin genotype testing ( DNA testing) can ...

  2. Alpha-1 antitrypsin test

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003715.htm Alpha-1 antitrypsin test To use the sharing features on this page, please enable JavaScript. Alpha-1 antitrypsin is a laboratory test to measure the ...

  3. Diabetes Type 1

    MedlinePlus

    ... blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin ... eyes, kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young ...

  4. Vought UO-1

    NASA Technical Reports Server (NTRS)

    1925-01-01

    Vought UO-1: Following the success of Vought's VE-7, the Vought UO-1 observation aircraft was produced, versions of which saw service as Vought FU fighters. This example was used by the NACA in engine supercharger work.

  5. A1C test

    MedlinePlus

    HbA1C test; Glycated hemoglobin test; Glycosylated hemoglobin test; Hemoglobin glycosylated test; Glycohemoglobin test ... have recently eaten does not affect the A1C test, so you do not need to fast to ...

  6. CCF Experiment #1

    NASA Video Gallery

    Images from CCF camera during Experiment #1, or EU#1, square groove geometry operations. The free surface, or gas/liquid interface, assumes a curved shape under subcritical flow conditions as its m...

  7. Interferon Alfacon-1 Injection

    MedlinePlus

    Interferon alfacon-1 is no longer available in the United States. If you are currently taking this medication, you should call ... another treatment.Your doctor has ordered interferon alfacon-1 to help treat your hepatitis C infection. The ...

  8. BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).

    PubMed

    Agsten, Marianne; Hessler, Sabine; Lehnert, Sandra; Volk, Tilmann; Rittger, Andrea; Hartmann, Stephanie; Raab, Christian; Kim, Doo Yeon; Groemer, Teja W; Schwake, Michael; Alzheimer, Christian; Huth, Tobias

    2015-12-01

    KCNQ1 (Kv7.1) proteins form a homotetrameric channel, which produces a voltage-dependent K(+) current. Co-assembly of KCNQ1 with the auxiliary β-subunit KCNE1 strongly up-regulates this current. In cardiac myocytes, KCNQ1/E1 complexes are thought to give rise to the delayed rectifier current IKs, which contributes to cardiac action potential repolarization. We report here that the type I membrane protein BACE1 (β-site APP-cleaving enzyme 1), which is best known for its detrimental role in Alzheimer's disease, but is also, as reported here, present in cardiac myocytes, serves as a novel interaction partner of KCNQ1. Using HEK293T cells as heterologous expression system to study the electrophysiological effects of BACE1 and KCNE1 on KCNQ1 in different combinations, our main findings were the following: (1) BACE1 slowed the inactivation of KCNQ1 current producing an increased initial response to depolarizing voltage steps. (2) Activation kinetics of KCNQ1/E1 currents were significantly slowed in the presence of co-expressed BACE1. (3) BACE1 impaired reconstituted cardiac IKs when cardiac action potentials were used as voltage commands, but interestingly augmented the IKs of ATP-deprived cells, suggesting that the effect of BACE1 depends on the metabolic state of the cell. (4) The electrophysiological effects of BACE1 on KCNQ1 reported here were independent of its enzymatic activity, as they were preserved when the proteolytically inactive variant BACE1 D289N was co-transfected in lieu of BACE1 or when BACE1-expressing cells were treated with the BACE1-inhibiting compound C3. (5) Co-immunoprecipitation and fluorescence recovery after photobleaching (FRAP) supported our hypothesis that BACE1 modifies the biophysical properties of IKs by physically interacting with KCNQ1 in a β-subunit-like fashion. Strongly underscoring the functional significance of this interaction, we detected BACE1 in human iPSC-derived cardiomyocytes and murine cardiac tissue and observed

  9. Just Perfect: Part 1

    ERIC Educational Resources Information Center

    Scott, Paul

    2007-01-01

    This article is about a very small subset of the positive integers. The positive integer N is said to be "perfect" if it is the sum of all its divisors, including 1, but less that N itself. For example, N = 6 is perfect, because the (relevant) divisors are 1, 2 and 3, and 6 = 1 + 2 + 3. On the other hand, N = 12 has divisors 1, 2, 3, 4 and 6, but…

  10. α1-Antitrypsin Deficiency.

    PubMed

    Hatipoğlu, Umur; Stoller, James K

    2016-09-01

    α1-Antitrypsin deficiency is an autosomal codominant condition that predisposes to emphysema and cirrhosis. The condition is common but grossly under-recognized. Identifying patients' α1-antitrypsin deficiency has important management implications (ie, smoking cessation, genetic and occupational counseling, and specific treatment with the infusion of pooled human plasma α1-antitrypsin). The weight of evidence suggests that augmentation therapy slows the progression of emphysema in individuals with severe α1-antitrypsin deficiency. PMID:27514595

  11. F-1 Engines

    NASA Technical Reports Server (NTRS)

    1965-01-01

    This photograph shows F-1 engines being stored in the F-1 Engine Preparation Shop, building 4666, at the Marshall Space Flight Center. Each F-1 engine produced a thrust of 1,500,000 pounds. A cluster of five engines was mounted on the thrust structure of the S-IC stage of a 364-foot long Saturn V launch vehicle that ultimately took astronauts to the Moon.

  12. Psychoneuroimmunology and HIV-1.

    ERIC Educational Resources Information Center

    Antoni, Michael H.; And Others

    1990-01-01

    Presents evidence describing benefits of behavioral interventions such as aerobic exercise training on both psychological and immunological functioning among high risk human immunodeficiency virus-Type 1 (HIV-1) seronegative and very early stage seropositive homosexual men. HIV-1 infection is cast as chronic disease for which early…

  13. MI1ANAV

    Atmospheric Science Data Center

    2014-09-03

    MI1ANAV MISR Level 1A Navigation Data: Reformatted Annotated Level 1A Product for the Navigation Data, which contains samples of the Terra Platform position and ... Specification Versioning History:  Engineering, Navigation SCAR-B Block:  SCAR-B ...

  14. Immunoprecipitation of ROR1

    PubMed Central

    Bicocca, Vincent T.; Tyner, Jeffrey W.

    2016-01-01

    ROR1 is a receptor tyrosine kinase family member studied for its roles in development and cancer. Here we describe a protocol for immunoprecipitation of endogenous ROR1 from t(1;19) (a disease subtype categorized by its chromosome translocation) acute lymphoblastic leukemia immortalized cell lines.

  15. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain

    PubMed Central

    Kutsuno, Yuki; Hirashima, Rika; Sakamoto, Masaya; Ushikubo, Hiroko; Michimae, Hirofumi; Itoh, Tomoo; Tukey, Robert H.

    2015-01-01

    Although UDP-glucuronosyltransferases (UGTs) are important phase II drug-metabolizing enzymes, they are also involved in the metabolism of endogenous compounds. Certain substrates of UGTs, such as serotonin and estradiol, play important roles in the brain. However, the expression of UGTs in the human brain has not been fully clarified. Recently, humanized UGT1 mice (hUGT1 mice) in which the original Ugt1 locus was disrupted and replaced with the human UGT1 locus have been developed. In the present study, the expression pattern of UGT1As in brains from humans and hUGT1 mice was examined. We found that UGT1A1, 1A3, 1A6, and 1A10 were expressed in human brains. The expression pattern of UGT1As in hUGT1 mouse brains was similar to that in human brains. In addition, we examined the expression of UGT1A1 and 1A6 in the cerebellum, olfactory bulbs, midbrain, hippocampus, and cerebral cortex of hUGT1 mice. UGT1A1 in all brain regions and UGT1A6 in the cerebellum and cerebral cortex of 6-month-old hUGT1 mice were expressed at a significantly higher rate than those of 2-week-old hUGT1 mice. A difference in expression levels between brain regions was also observed. Brain microsomes exhibited glucuronidation activities toward estradiol and serotonin, with mean values of 0.13 and 5.17 pmol/min/mg, respectively. In conclusion, UGT1A1 and UGT1A6 might play an important role in function regulation of endogenous compounds in a region- and age-dependent manner. Humanized UGT1 mice might be useful to study the importance of brain UGTs in vivo. PMID:25953521

  16. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Here the transparent furnace is extracted for servicing. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

  17. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, and TBD). This composite is from a digital still camera; higher resolution is not available.

  18. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

  19. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101830, and TBD).

  20. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD). This image is from a digital still camera; higher resolution is not available.

  1. Microhydropower Handbook, Volume 1, Part 1

    SciTech Connect

    McKinney, J.D.

    1983-01-01

    The purpose of the “Microhydropower Handbook, Volume 1, Part 1” is to provide a mechanically proficient lay person with sufficient information to evaluate microhydropower site potential, lay out a site, select and install equipment, and finally, operate and maintain the completed system. The actual construction details of the site are not included; rather, pointers are given as to what help an individual should expect from a construction contractor, and general guidelines on construction details are provided. In addition, information about obtaining financing and permits is provided. To help offset cost, the person performing the work, referred to as the “developer,” is encouraged to do as much of the work as possible. However, developers with major areas of uncertainty should consider professional assistance.

  2. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

  3. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. A larger image is available without labels (No. 0101755).

  4. Materials Science Research Rack-1 (MSRR-1)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830).

  5. Horizontally separated 1-in-1 crossing insertions

    SciTech Connect

    Syphers, M.J.

    1985-10-01

    Previous to this workshop, realistic lattices have been developed for vertically separated l-in-l (e.g., D.E. Johnson, A.A. Garren) and 2-in-1 (e.g., S. Heifets) magnets as well as for horizontally separated 2-in-l magnets (e.g., SSC RDS). Bringing together the widely separated ({approximately}60-70 cm) beams in a reasonable length of tunnel and keeping the dispersion zero at the interaction point has been difficult in the vertical l-in-l case. Most designs have required spacial 2-in-1 quadrupoles near the interaction point where the beams are separated by 15 cm or less. It is not clear that such magnets, as dictated by some of these lattice designs, can easily be built. The purpose of this exercise is to provide a crossing insertion for a realistic lattice which involves horizontally separated l-in-l magnets. The following horizontal crossing insertions, which incorporate the dispersion suppressors and phase trombones into the major arcs, need no special 2-in-1 magnets near the interaction point. The dispersion at the IP created by the horizontal crossing can be cancelled by the dispersion suppressor and one set of triplets.

  6. Photochemical Transformation and Phototoxicity of 1-Aminopyrene

    PubMed Central

    Zeng, Kui; Hwang, Huey-Min; Dong, Shiming; Shi, Xiaochun; Wilson, Kaneytta; Green, Jacinta; Jiao, Yuguo; Yu, Hongtao

    2013-01-01

    1-Aminopyrene (1-AP) is an environmental mutagen and a metabolite of the mutagenic environmental pollutant, 1-nitropyrene (1-NO2P). Upon light irradiation, 1-AP transforms into oxidation products with a half-life of 7.1 min in 10% methanolic buffer. The presence of free radical/singlet oxygen scavengers DTT, histidine, or NaN3, slows down 1-AP photochemical reaction. The reaction is also slower in the presence of DNA. The photoproducts identified include 1-hydroxyaminopyrene, 1-nitrosopyrene, 1-NO2P, 1-amino-x-hydroxypyrene, and three covalent dimers. The progressive oxidation of the amino group to hydroxyamino, nitroso, and finally nitro is the reverse of the enzymatic reduction of 1-NO2P in living systems. Since it is known that 1-NO2P and 1-nitrosopyrene are genotoxic and 1-hydroxyaminopyrnene can react with DNA to form covalent adducts, the toxicity of 1-AP and its photoproducts and light-induced DNA covalent adduct formation were studied. Using Mutatox® Test, it is found that the lowest effective observable concentrations for 1-AP, 1-AP photoproducts, and 1-NO2P are 1.25, 10, and NA (not applicable) in the direct medium (no S-9) and NA, 5, and 0.625 μM in the S-9 medium, respectively. Therefore, 1-AP photoproducts are more genotoxic than 1-AP itself in the S-9 medium and more mutagenic than 1-NO2P in the direct medium. Thus 1-NO2P alone cannot account for all the mutagenicity of the photoproducts. Irradiation of 1-AP together with DNA leads to covalent DNA adduct formation possibly via the 1-hydroxyaminopyrene intermediate. This suggests that photolysis not only transforms 1-AP into more mutagenic compounds, but also forms DNA covalent adducts. PMID:15376525

  7. The Ufm1 Cascade

    PubMed Central

    Daniel, Jens; Liebau, Eva

    2014-01-01

    The ubiquitin-fold modifier 1 (Ufm1) is a posttranslational modifier that belongs to the ubiquitin-like protein (UBL) family. Ufm1 is present in nearly all eukaryotic organisms, with the exception of fungi. It resembles ubiquitin in its ability to be ligated to other proteins, as well as in the mechanism of ligation. While the Ufm1 cascade has been implicated in endoplasmic reticulum functions and cell cycle control, its biological role still remains poorly understood. In this short review, we summarize the current state of Ufm1 research and its potential role in human diseases, like diabetes, ischemic heart disease and cancer. PMID:24921187

  8. Quantum Max-flow/Min-cut

    NASA Astrophysics Data System (ADS)

    Cui, Shawn X.; Freedman, Michael H.; Sattath, Or; Stong, Richard; Minton, Greg

    2016-06-01

    The classical max-flow min-cut theorem describes transport through certain idealized classical networks. We consider the quantum analog for tensor networks. By associating an integral capacity to each edge and a tensor to each vertex in a flow network, we can also interpret it as a tensor network and, more specifically, as a linear map from the input space to the output space. The quantum max-flow is defined to be the maximal rank of this linear map over all choices of tensors. The quantum min-cut is defined to be the minimum product of the capacities of edges over all cuts of the tensor network. We show that unlike the classical case, the quantum max-flow=min-cut conjecture is not true in general. Under certain conditions, e.g., when the capacity on each edge is some power of a fixed integer, the quantum max-flow is proved to equal the quantum min-cut. However, concrete examples are also provided where the equality does not hold. We also found connections of quantum max-flow/min-cut with entropy of entanglement and the quantum satisfiability problem. We speculate that the phenomena revealed may be of interest both in spin systems in condensed matter and in quantum gravity.

  9. L1 retrotransposition

    PubMed Central

    Viollet, Sébastien; Monot, Clément; Cristofari, Gaël

    2014-01-01

    LINE-1 (L1) elements are the only active and autonomous transposable elements in humans. The core retrotransposition machinery is a ribonucleoprotein particle (RNP) containing the L1 mRNA, with endonuclease and reverse transcriptase activities. It initiates reverse transcription directly at genomic target sites upon endonuclease cleavage. Recently, using a direct L1 extension assay (DLEA), we systematically tested the ability of native L1 RNPs to extend DNA substrates of various sequences and structures. We deduced from these experiments the general rules guiding the initiation of L1 reverse transcription, referred to as the snap-velcro model. In this model, L1 target choice is not only mediated by the sequence specificity of the endonuclease, but also through base-pairing between the L1 mRNA and the target site, which permits the subsequent L1 reverse transcription step. In addition, L1 reverse transcriptase efficiently primes L1 DNA synthesis only when the 3′ end of the DNA substrate is single-stranded, suggesting so-far unrecognized DNA processing steps at the integration site. PMID:24818067

  10. The E1 proteins

    SciTech Connect

    Bergvall, Monika; Melendy, Thomas; Archambault, Jacques

    2013-10-15

    E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structural studies have revealed the assembly pathway of E1 at the origin and how the enzyme unwinds DNA using a spiral escalator mechanism. E1 is tightly regulated in vivo, in particular by post-translational modifications that restrict its accumulation in the nucleus. Here we review how different functional domains of E1 orchestrate viral DNA replication, with an emphasis on their interactions with substrate DNA, host DNA replication factors and modifying enzymes. These studies have made E1 one of the best characterized helicases and provided unique insights on how PVs usurp different host-cell machineries to replicate and amplify their genome in a tightly controlled manner. - Highlights: • The papillomavirus E1 helicase orchestrates replication of the viral DNA genome. • E1 assembles into a double-hexamer at the viral origin with the help of E2. • E1 interacts with cellular DNA replication factors. • E1 unwinds DNA using a spiral escalator mechanism. • Nuclear accumulation of E1 is regulated by post-translational modifications.

  11. Sphingosine 1-phosphate signalling.

    PubMed

    Mendelson, Karen; Evans, Todd; Hla, Timothy

    2014-01-01

    Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease. PMID:24346695

  12. Rat Organic Anion Transporting Protein 1A1 (OATP1A1)

    PubMed Central

    Xiao, Yansen; Nieves, Edward; Angeletti, Ruth H.; Orr, George A.; Wolkoff, Allan W.

    2008-01-01

    Rat organic anion transporting protein 1a1 (oatp1a1), a hepatocyte basolateral plasma membrane protein, mediates transport of various amphipathic compounds. Our previous studies indicated that serine phosphorylation of a single tryptic peptide inhibits its transport activity without changing its cell surface content. The site of phosphorylation is unknown and was the subject of the present study. Following immunoaffinity chromatographic purification from rat liver, oatp1a1 was subjected to trypsin digestion and MALDI-TOF. Except for predicted N-glycosylated peptides, 97% of oatp1a1 tryptic peptides were observed. A single tryptic phosphopeptide was found in the C-terminus (aa 626-647), existing in unphosphorylated, singly, or doubly phosphorylated forms, and sensitive to alkaline phosphatase treatment. β-elimination reaction resulted in mass loss of 98 or 196 Da from this peptide, and subsequent Michael addition with cysteamine increased masses by the predicated 77 and 154 Da, indicating that oatp1a1 can be singly or doubly phosphorylated at serine or threonine residues in the C-terminal sequence SSATDHT (aa 634-640). Subsequent tandem MS/MS analysis revealed that phosphorylation at S634 accounted for all singly phosphorylated peptide, while phosphorylation at S634 and S635 accounted for all doubly phosphorylated peptide. These findings identify the site of oatp1a1 phosphorylation and demonstrate that it is an ordered process, in which phosphorylation at S634 precedes that at S635. The mechanism by which phosphorylation results in loss of transport activity in hepatocytes remains to be established. Whether phosphorylation near the C-terminus inhibits C-terminal oligomerization of oatp1a1, required for normal transport function, can be speculated upon, but is as yet unknown. PMID:16519530

  13. Prokineticin1 and pregnancy.

    PubMed

    Alfaidy, Nadia

    2016-06-01

    Prokineticin 1 (PROK1), also called EG-VEGF, is a peptide of 86 amino acids with multiple biological functions. PROK1 acts via two G-protein coupled receptors: PROKR1 PROKR2. PROK1 is highly expressed in the placenta. This article reports the expression and the role of PROK1 during normal and pathological pregnancies: (i) during early pregnancy, PROK1 exhibits a peak of placental expression shortly before the establishment of the feto-maternal circulation; (ii) its receptors, PROKR1 PROKR2 are highly expressed in human placenta; (iii) its expression is increased by hypoxia; (iv) PROK1 inhibits extravillous trophoblasts migration and invasion and increases their proliferation and survival; (v) PROK1 is also a pro-angiogenic placental factor that increases microvascular placental endothelial cells proliferation, migration, invasion, and permeability. Circulating PROK1 levels are five times higher in pregnant women during the first trimester compared to the second and third trimesters. Also, its serum levels are higher in patients with preeclampsia (PE) and in patients with isolated intra-uterine growth restriction (IUGR). In mice, maintaining high level of PROK1 beyond its normal period of production (>10.5dpc) reproduces symptoms of PE. To date, our results demonstrated that PROK1 is a central factor of human placentation with direct roles both in the control of trophoblast invasion and villous growth. Thus, a failure in the expression of PROK1 and/or its receptor during pregnancy may contribute to the development of PE and/or IUGR. Besides theses original findings, we also report a direct role of this factor in parturition. PMID:27172869

  14. MinFinder v2.0: An improved version of MinFinder

    NASA Astrophysics Data System (ADS)

    Tsoulos, Ioannis G.; Lagaris, Isaac E.

    2008-10-01

    A new version of the "MinFinder" program is presented that offers an augmented linking procedure for Fortran-77 subprograms, two additional stopping rules and a new start-point rejection mechanism that saves a significant portion of gradient and function evaluations. The method is applied on a set of standard test functions and the results are reported. New version program summaryProgram title: MinFinder v2.0 Catalogue identifier: ADWU_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWU_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC Licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 14 150 No. of bytes in distributed program, including test data, etc.: 218 144 Distribution format: tar.gz Programming language used: GNU C++, GNU FORTRAN, GNU C Computer: The program is designed to be portable in all systems running the GNU C++ compiler Operating system: Linux, Solaris, FreeBSD RAM: 200 000 bytes Classification: 4.9 Catalogue identifier of previous version: ADWU_v1_0 Journal reference of previous version: Computer Physics Communications 174 (2006) 166-179 Does the new version supersede the previous version?: Yes Nature of problem: A multitude of problems in science and engineering are often reduced to minimizing a function of many variables. There are instances that a local optimum does not correspond to the desired physical solution and hence the search for a better solution is required. Local optimization techniques can be trapped in any local minimum. Global optimization is then the appropriate tool. For example, solving a non-linear system of equations via optimization, one may encounter many local minima that do not correspond to solutions, i.e. they are far from zero. Solution method: Using a uniform pdf, points are sampled from a rectangular domain. A clustering technique, based on a typical distance

  15. SAF1. Standard Agent Framework 1

    SciTech Connect

    Goldsmith, S.Y

    1997-06-01

    The Standard Agent framework provides an extensible object-oriented development environment suitable for use in both research and applications projects. The SAF provides a means for constructing and customizing multi-agent systems through specialization of standard base classes (architecture-driven framework) and by composition of component classes (data driven framework). The standard agent system is implemented as an extensible object-centerd framework. Four concrete base classes are developed: (1) Standard Agency; (2) Standard Agent; (3) Human Factor, and (4) Resources. The object-centered framework developed and utilized provides the best comprimise between generality and flexibility available in agent development systems today.

  16. Learnability of min-max pattern classifiers

    NASA Astrophysics Data System (ADS)

    Yang, Ping-Fai; Maragos, Petros

    1991-11-01

    This paper introduces the class of thresholded min-max functions and studies their learning under the probably approximately correct (PAC) model introduced by Valiant. These functions can be used as pattern classifiers of both real-valued and binary-valued feature vectors. They are a lattice-theoretic generalization of Boolean functions and are also related to three-layer perceptrons and morphological signal operators. Several subclasses of the thresholded min- max functions are shown to be learnable under the PAC model.

  17. The NLRP1 inflammasomes.

    PubMed

    Chavarría-Smith, Joseph; Vance, Russell E

    2015-05-01

    Inflammasomes are cytosolic protein complexes that serve as platforms for the recruitment and activation of the pro-inflammatory CASPASE-1 protease. CASPASE-1 activation leads to processing and maturation of the cytokines interleukin-1β and interleukin-18 and a lytic form of cell death termed pyroptosis. Inflammasome assembly is initiated by cytosolic sensors in response to microbial infections. Many of these sensors, including NLRP1 (NLR family, pyrin domain containing 1), are described to form an inflammasome, but until recently, the mechanism of inflammasome activation and its physiological functions in host defense have remained unclear. In the last few years, important advances in our understanding of NLRP1 biology have been achieved. In this review, we discuss the activation of NLRP1 by various stimuli, including Bacillus anthracis lethal toxin, Toxoplasma gondii, muramyl dipeptide, and host intracellular ATP depletion. The role NLRP1 plays in pathogen recognition and resistance during infection is also discussed, as is the regulation of NLRP1 by host and viral proteins. We conclude by discussing the unexpected differences in the mechanism of NLRP1 inflammasome activation, as compared to the activation of other inflammasomes, such as the NAIP (NLR family, apoptosis inhibitory protein)/NLRC4 inflammasomes. PMID:25879281

  18. Niemann-Pick C1-Like 1 (NPC1L1) Inhibition and Cardiovascular Diseases.

    PubMed

    Pirillo, A; Catapano, A L; Norata, G D

    2016-01-01

    Circulating levels of cholesterol are derived from either endogenous production or intestinal absorption of dietary and biliary cholesterol. Niemann-Pick C1-Like 1 (NPC1L1) is a transmembrane protein that plays a key role in the intestinal absorption of cholesterol by facilitating its uptake through vesicular endocytosis. NPC1L1 is the molecular target of ezetimibe which binds its extracellular loop and inhibits sterol absorption without affecting the absorption of other molecules. Ezetimibe significantly reduces plasma levels of total and low density lipoprotein cholesterol (LDL-C) as monotherapy or when added to statins, the association with a low dose of statin is of particular interest for patients experiencing statin-related side effects. The recent results of the IMPROVE-IT study, which evaluated the cardiovascular effect of ezetimibe added to simvastatin therapy in subjects who had had an acute coronary syndrome and with LDL-C levels within the recommended range, showed that a further LDL-C lowering reduced the incidence of cardiovascular events. To date, ezetimibe represents the only inhibitor of NPC1L1 available for clinical use, however, novel aminoß- lactam ezetimibe derivatives have been synthesized and their efficacy to inhibit NPC1L1 protein and decrease plasma cholesterol levels is under evaluation. PMID:26923679

  19. α1-Antitrypsin deficiency.

    PubMed

    Greene, Catherine M; Marciniak, Stefan J; Teckman, Jeffrey; Ferrarotti, Ilaria; Brantly, Mark L; Lomas, David A; Stoller, James K; McElvaney, Noel G

    2016-01-01

    α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes underdiagnosed or misdiagnosed as asthma, chronic obstructive pulmonary disease (COPD) or cryptogenic liver disease. The most frequent disease-associated mutations include the S allele and the Z allele of SERPINA1, which lead to the accumulation of misfolded α1-antitrypsin in hepatocytes, endoplasmic reticulum stress, low circulating levels of α1-antitrypsin and liver disease. Currently, there is no cure for severe liver disease and the only management option is liver transplantation when liver failure is life-threatening. A1ATD-associated lung disease predominately occurs in adults and is caused principally by inadequate protease inhibition. Treatment of A1ATD-associated lung disease includes standard therapies that are also used for the treatment of COPD, in addition to the use of augmentation therapy (that is, infusions of human plasma-derived, purified α1-antitrypsin). New therapies that target the misfolded α1-antitrypsin or attempt to correct the underlying genetic mutation are currently under development. PMID:27465791

  20. Alteration of fatal 1:1 conducted atrial flutter to less conducted ratio by landiolol infusion.

    PubMed

    Takata, Junko; Haruyama, Naoko; Arashi, Tomoko; Mae, Tomoko

    2016-08-01

    An 84-year-old male patient with a past history of atrial-flutter-fibrillation and dementia underwent an urgent femoral neck fracture surgery. Preoperative electrocardiography demonstrated atrial flutter (AFL) with ventricular conduction at a ratio of 2:1-4:1, and transthoracic echocardiography showed severe left ventricular dysfunction with Ejection Fraction of 14.6 %. Femoral nerve block and Lateral femoral cutaneous nerve block with sedation was planned for the surgery. Upon entry to the operating room, ECG showed 2:1 conducted AFL at the rate of 128 beats min(-1). Due to the stimulation of urethral catheter insertion, it has altered to 1:1 conducted AFL. Loading dose of landiolol hydrochloride 7.5 mg followed by 1.5-3 μg/kg/min continuous administration was given, which had decreased the conduction ratio to 2:1 without causing hypotension. A further episode of 1:1 conducted AFL occurred when the pin was inserted to the thighbone, which caused circulatory collapse. Additional bolus dose of landiolol immediately altered it to 2:1 before operating cardioversion and stabilized the hemodynamics. He maintained AFL with 2:1 conduction thereafter, and 1:1 conduction was never seen postoperatively even after discontinuation of landiolol. PMID:27085543

  1. X-1 in flight

    NASA Technical Reports Server (NTRS)

    1947-01-01

    The Bell Aircraft Corporation X-1-1 (#46-062) in flight. The shock wave pattern in the exhaust plume is visible. The X-1 series aircraft were air-launched from a modified Boeing B-29 or a B-50 Superfortress bombers. The X-1-1 was painted a bright orange by Bell Aircraft. It was thought that the aircraft would be more visable to those doing the tracking during a flight. When NACA received the airplanes they were painted white, which was an easier color to find in the skies over Muroc Air Field in California. This particular craft was nicknamed 'Glamorous Glennis' by Chuck Yeager in honor of his wife, and is now on permanent display in the Smithsonian Institution's National Air and Space Museum in Washington, DC. There were five versions of the Bell X-1 rocket-powered research aircraft that flew at the NACA High-Speed Flight Research Station, Edwards, California. The bullet-shaped X-1 aircraft were built by Bell Aircraft Corporation, Buffalo, N.Y. for the U.S. Army Air Forces (after 1947, U.S. Air Force) and the National Advisory Committee for Aeronautics (NACA). The X-1 Program was originally designated the XS-1 for EXperimental Sonic. The X-1's mission was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' Three different X-1s were built and designated: X-1-1, X-1-2 (later modified to become the X-1E), and X-1-3. The basic X-1 aircraft were flown by a large number of different pilots from 1946 to 1951. The X-1 Program not only proved that humans could go beyond the speed of sound, it reinforced the understanding that technological barriers could be overcome. The X-1s pioneered many structural and aerodynamic advances including extremely thin, yet extremely strong wing sections; supersonic fuselage configurations; control system requirements; powerplant compatibility; and cockpit environments. The X-1 aircraft were the first transonic-capable aircraft to use an all

  2. 26 CFR 1.952-1 - Subpart F income defined.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... applicable to taxable years beginning before January 1, 1967, see 26 CFR 1.952-1(b)(1) (Revisedof April 1... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Subpart F income defined. 1.952-1 Section 1.952... (CONTINUED) INCOME TAXES Controlled Foreign Corporations § 1.952-1 Subpart F income defined. (a) In...

  3. 26 CFR 1.1-2 - Limitation on tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Limitation on tax. 1.1-2 Section 1.1-2 Internal... Surtaxes § 1.1-2 Limitation on tax. (a) Taxable years ending before January 1, 1971. For taxable years ending before January 1, 1971, the tax imposed by section 1 (whether by subsection (a) or subsection...

  4. 26 CFR 1.331-1 - Corporate liquidations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... before May 30, 2006, see § 1.331-1 as contained in 26 CFR part 1 in effect on April 1, 2006. ... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Corporate liquidations. 1.331-1 Section 1.331-1...) INCOME TAXES Corporate Liquidations § 1.331-1 Corporate liquidations. (a) In general. Section...

  5. Event generation with SHERPA 1.1

    SciTech Connect

    Gleisberg, T.; Hoche, Stefan.; Krauss, F.; Schoenherr, M.; Schumann, S.; Siegert, F.; Winter, J.

    2008-12-18

    In this paper the current release of the Monte Carlo event generator Sherpa, version 1.1, is presented. Sherpa is a general-purpose tool for the simulation of particle collisions at high-energy colliders. It contains a very flexible tree-level matrix-element generator for the calculation of hard scattering processes within the Standard Model and various new physics models. The emission of additional QCD partons off the initial and final states is described through a parton-shower model. To consistently combine multi-parton matrix elements with the QCD parton cascades the approach of Catani, Krauss, Kuhn and Webber is employed. A simple model of multiple interactions is used to account for underlying events in hadron-hadron collisions. The fragmentation of partons into primary hadrons is described using a phenomenological cluster-hadronization model. A comprehensive library for simulating tau-lepton and hadron decays is provided. Where available form-factor models and matrix elements are used, allowing for the inclusion of spin correlations; effects of virtual and real QED corrections are included using the approach of Yennie, Frautschi and Suura.

  6. [NDM-1: the superbug?].

    PubMed

    Pittalis, S; Ferarro, F; Puro, V

    2011-12-01

    A novel type of carbapenemase, New Delhi metallo beta-lactamase 1 (NDM 1), was first identified in 2008 in two Enterobacteriacea isolates, both recovered from a Swedish patient transferred from India. The emergence of NDM 1 is now reported from all continents, often in patients with a history of travel or hospitalization in the Indian subcontinent. The NDM 1 producing Gram-negative bacteria are mainly Enterobacteriaceae, which can cause colonization or fatal infections, with worrying antimicrobial susceptibility profiles: some isolates have developed resistance to practically all available antibiotics. Is the NDM-1 the super-bug? Are we in the post-antibiotic era? This review is a summary of currently available knowledge of NDM-1 that draws attention to future antimicrobial resistance scenarios. PMID:22212161

  7. The effects of tones on speaking frequency and intensity ranges in Mandarin and Min dialects

    NASA Astrophysics Data System (ADS)

    Chen, Sheng H.

    2005-05-01

    The differences of speaking frequency and intensity in different tonal dialects has not been widely investigated. The purposes of this study were (1) to compare the speaking frequency and speaking intensity ranges of Mandarin and Min and (2) to compare the speaking frequency and intensity ranges of Mandarin and Min to those of American English. The subjects were 80 normal Taiwanese adults divided into two dialect groups, Mandarin and Min. The speaking F0, the highest speaking F0, the lowest speaking F0, the maximum range of speaking F0, and the intensity counterpart were obtained from reading in their native dialects. Statistical analysis revealed that Min speakers had a significantly greater maximum range of speaking intensity and a smaller lowest speaking intensity than Mandarin speakers, which indicated tonal effects by speakers of the Min dialect. Moreover, Mandarin and Min speakers had a greater maximum range of speaking F0 and maximum range of speaking intensity than American English speakers. The data may provide an assessment tool for Mandarin speakers and Min speakers. .

  8. Identification of Dehalobacter reductive dehalogenases that catalyse dechlorination of chloroform, 1,1,1-trichloroethane and 1,1-dichloroethane

    PubMed Central

    Tang, Shuiquan; Edwards, Elizabeth A.

    2013-01-01

    Two novel reductive dehalogenases (RDases) that are highly similar to each other but catalyse distinct dechlorination reactions were identified from Dehalobacter-containing mixed cultures. These two RDases were partially purified from crude protein extracts of anaerobic dechlorinating enrichment cultures using blue native polyacrylamide gel electrophoresis. Gel slices were assayed for dechlorinating activity, and associated proteins were identified using liquid chromatography tandem mass spectrometry with the metagenome of the parent culture as the reference database. The two RDases identified, annotated as CfrA and DcrA, share an amino acid identity of 95.2 per cent, but use different substrates: CfrA dechlorinates chloroform (CF) and 1,1,1-trichloroethane (1,1,1-TCA), but not 1,1-dichloroethane; DcrA dechlorinates 1,1-dichloroethane, but not CF or 1,1,1-TCA. These two novel RDases share no more than 40 per cent amino acid identity to any other known or putative RDases, but both have a twin-arginine motif and two iron–sulfur binding motifs conserved in most RDases. Peptides specific to two putative membrane anchor proteins, annotated as CfrB and DcrB, were also detected in gel slices. PMID:23479748

  9. MICAL-L1

    PubMed Central

    Sharma, Mahak; Giridharan, Sai Srinivas Panapakkam; Rahajeng, Juliati

    2010-01-01

    A key regulator of the slow recycling of receptors and lipids that occurs from the endocytic recycling compartment (ERC) back to the cell surface is EHD1. We have recently identified the Rab8a-interacting protein, MICAL-L1, as a novel binding partner for EHD1 that both recruits and interacts with EHD1 on tubular recycling endosomes. MICAL-L1 belongs to the MICALfamily of proteins that are highly expressed in neurons and involved in plexin-mediated repulsive axon guidance. Interestingly, MICAL-L1 contains a coiled coil region in its C-terminus that is both necessary and sufficient for its localization to the EHD1-containing long tubular membranes of the ERC. Furthermore, MICAL-L1-depletion also impaired recycling of both transferrin and integrin receptors from the ERC back to the plasma membrane. In conclusion, our studies implicate MICAL-L1 as a novel regulator of endocytic recycling, and raises the possibility that additional neuronal-expressed proteins may mediate endocytic events in non-neuronal cells. PMID:20585517

  10. The Osborne 1.

    ERIC Educational Resources Information Center

    McWilliams, Peter

    1982-01-01

    Describes the unique features, available software, performance capabilities, system options, costs, advantages, disadvantages, and eccentricities of the Osborne 1 microcomputer. A table summarizes specifications, features, and costs. (JL)

  11. Discrimination between ETA- and ETB-receptor-mediated effects of endothelin-1 and [Ala1,3,11,15]endothelin-1 by BQ-123 in the anaesthetized rat.

    PubMed Central

    Bigaud, M.; Pelton, J. T.

    1992-01-01

    1. The influence of BQ-123 (a selective ETA-receptor antagonist) on the haemodynamic response elicited by endothelin-1 (ET-1) and [Ala1,3,11,15]ET-1 (a selective ETB-receptor agonist) was studied in anaesthetized rats instrumented with ultrasonic Doppler flow probes on the carotid, coeliac, mesenteric, renal and iliac arteries. 2. BQ-123 alone (1.6 mumol kg-1, i.v.) induced a decrease in femoral mean arterial pressure (AP), accompanied by a systemic vasodilatation. The response was maximal after 3 min and then returned slowly to baseline. None of these effects was observed after a 0.016 mumol kg-1 dose of BQ-123. 3. ET-1 (1 nmol kg-1, i.v.) induced a biphasic response characterized by a transient initial decrease in AP accompanied by regional vasodilatation (mainly in the carotid and iliac beds) and by immediate mesenteric and renal vasoconstrictions. This was followed, within 1 min, by a marked and prolonged increase in AP accompanied by systemic vasoconstriction. Pretreatment with BQ-123 (1.6 mumol kg-1, i.v., 8 min before ET-1) increased and prolonged the vasodilator effect of ET-1 (mainly in the carotid, coeliac, mesenteric and iliac beds) and reduced its systemic vasoconstrictor effects with marked regional differences (the coeliac, mesenteric and renal beds being poorly affected). 4. [Ala1,3,11,15]ET-1 (3 nmol kg-1, i.v.) induced an initial and marked decrease in AP accompanied by regional vasodilatation (mainly in the carotid, coeliac and iliac beds) and by mesenteric and renal vasoconstrictions. This was followed, within 5 min, by a small increase in AP and systemic vasoconstriction. All these effects were dose-dependent.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1467841

  12. Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus).

    PubMed

    Wilson, Joanna Y; Moore, Michael J; Stegeman, John J

    2010-02-18

    We have characterized microsomal systems and measured the levels of microsomal cytochrome P450 1A1 (CYP1A1) and ethoxyresorufin-O-deethylase (EROD) activity in multiple internal organs of male and female white-sided dolphin (Lagenorhynchus acutus) from the northwest Atlantic Ocean. Internal organs were sampled within 24h of death, sometimes in a period of hours, collection times which are significantly less than usually seen for marine mammals. Tissue autolysis, as assessed by histological analysis of liver, was minimal to none in all individuals. Total P420 did not correlate with time from death to sampling, suggesting that it is a poor indicator of P450 degradation in cetacean tissues where perfusion is not practical. The total hepatic microsomal P450 content, cytochrome b5 content, and NADPH-cytochrome c (P450) reductase (CPR) activity averaged 0.29nmolmg(-1), 0.12nmolmg(-1), and 238nmolmg(-1)min(-1), respectively. Microsomal CPR activity in liver was higher than that in lung and kidney, and was higher than that reported in liver of most other cetacean species. Immunodetected CYP1A1 content was low in all organs, less than 3pmolesCYP1A equivalentsmg(-1). EROD activity ranged from 9 to 376pmolesmg(-1)min(-1) and was greater in liver than in other tissues. Hepatic microsomal EROD activity and CYP1A1 content did not correlate. However, hepatic EROD activity, but not CYP1A1 protein content, was well correlated with both total PCB and Sigmamono-ortho PCB concentrations in blubber. Length, as a proxy for age, did not correlate with hepatic EROD activity or CYP1A1 protein levels, and sex did not influence the relationship between EROD and contaminant concentrations. We cannot easily control for the extent of tissue degradation in cetacean studies nor do we have a complete history of these animals. Therefore, other factors such as degradation or hormonal state may have a role in the observed relationships. Yet, as in other mammals, hepatic tissues appear to be a major

  13. Influenza Stigma during the 2009 H1N1 Pandemic

    PubMed Central

    Earnshaw, Valerie A.; Quinn, Diane M.

    2012-01-01

    The current study examines the extent to which H1N1 was stigmatized at the height of the 2009 H1N1 pandemic in the U.S. and explores the role that H1N1 stigma played in people’s desire for physical distance from others with H1N1. H1N1 was the most stigmatized disease, with participants endorsing greater prejudice towards people with H1N1 than people with cancer or HIV/AIDS. Further, H1N1 stigma partially mediated the relationship between participants’ perceptions that H1N1 was threatening and their desire for physical distance from people with H1N1. Therefore, H1N1 stigma played a role in, but was not entirely responsible for, the relationship between perceptions that H1N1 was threatening and desire for distance from others with H1N1. PMID:24244047

  14. Effect of Antimicrobial Agents on MinD Protein Oscillations in E. coli Bacterial Cells

    NASA Astrophysics Data System (ADS)

    Kelly, Corey; Giuliani, Maximiliano; Dutcher, John

    2012-02-01

    The pole-to-pole oscillation of MinD proteins in E. coli cells determines the location of the division septum, and is integral to healthy cell division. It has been shown previously that the MinD oscillation period is approximately 40 s for healthy cells [1] but is strongly dependant on environmental factors such as temperature, which may place stress on the cell [2,3]. We use a strain of E. coli in which the MinD proteins are tagged with green fluorescent protein (GFP), allowing fluorescence visualization of the MinD oscillation. We use high-resolution total internal reflection fluorescence (TIRF) microscopy and a custom, temperature controlled flow cell to observe the effect of exposure to antimicrobial agents on the MinD oscillation period and, more generally, to analyze the time variation of the spatial distribution of the MinD proteins within the cells. These measurements provide insight into the mechanism of antimicrobial action. [1] Raskin, D.M.; de Boer, P. (1999) Proc. Natl. Acad. Sci. 96: 4971-4976. [2] Touhami, A.; Jericho, M; Rutenberg, A. (2006) J. Bacteriol. 188: 7661-7667. [3] Downing, B.; Rutenberg, A.; Touhami, A.; Jericho, M. (2009) PLoS ONE 4: e7285.

  15. Quercetin Supplementation Attenuates the Progression of Cancer Cachexia in ApcMin/+ Mice123

    PubMed Central

    Velázquez, Kandy T.; Enos, Reilly T.; Narsale, Aditi A.; Puppa, Melissa J.; Davis, J. Mark; Murphy, E. Angela; Carson, James A.

    2014-01-01

    Although there are currently no approved treatments for cancer cachexia, there is an intensified interest in developing therapies because of the high mortality index associated with muscle wasting diseases. Successful treatment of the cachectic patient focuses on improving or maintaining body weight and musculoskeletal function. Nutraceutical compounds, including the natural phytochemical quercetin, are being examined as potential treatments because of their anti-inflammatory, antioxidant, and anticarcinogenic properties. The purpose of this study was to determine the effect of quercetin supplementation on the progression of cachexia in the adenomatous polyposis coli (Apc)Min/+ mouse model of colorectal cancer. At 15 wk of age, C57BL/6 and male ApcMin/+ mice were supplemented with 25 mg/kg of quercetin or vehicle solution mix of Tang juice and water (V) daily for 3 wk. Body weight, strength, neuromuscular performance, and fatigue were assessed before and after quercetin or V interventions. Indicators of metabolic dysfunction and inflammatory signaling were also assessed. During the treatment period, the relative decrease in body weight in the ApcMin/+ mice gavaged with V (ApcMin/+V; −14% ± 2.3) was higher than in control mice gavaged with V (+0.6% ± 1.0), control mice gavaged with quercetin (−2% ± 1.0), and ApcMin/+ mice gavaged with quercetin (ApcMin/+Q; −9% ± 1.3). At 18 wk of age, the loss of grip strength and muscle mass shown in ApcMin/+V mice was significantly attenuated (P < 0.05) in ApcMin/+Q mice. Furthermore, ApcMin/+V mice had an induction of plasma interleukin-6 and muscle signal transducer and activator of transcription 3 phosphorylation, which were significantly (P < 0.05) mitigated in ApcMin/+Q mice, despite having a similar tumor burden. Quercetin treatment did not improve treadmill run-time-to-fatigue, hyperglycemia, or hyperlipidemia in cachectic ApcMin/+ mice. Overall, quercetin supplementation positively affected several aspects of

  16. Conversion of erythro-D-sphinganine to its (1-/sup 2/H/sub 1/) and (1-/sup 3/H/sub 1/) derivatives

    SciTech Connect

    Crossman, M.W.; Hirschberg, C.B.

    1984-07-01

    A convenient chemical synthesis of erythro-D-(1-2H1) sphinganine and erythro-D-(1-3H1)sphinganine is described. The approach utilizes a stereospecific starting material (natural sphinganine prepared from bovine brain sphingomyelin) and applies a sequence of selective protection of functional groups yielding 2-acetamido-3-O-benzoyloctadecan-1-ol. Oxidation of the primary alcohol to an aldehyde followed by NaB2H4 or NaB3H4 reduction and hydrolysis of the protective groups yields erythro-D-(1-2H1)sphinganine or erythro-D-(1-3H1)sphinganine. The synthetic intermediates and isotopically labeled sphinganines are characterized by infrared analysis, 1H-nuclear magnetic resonance, optical rotation, and gas-liquid radiochromatographic and mass spectral fragmentation analyses. The (1-2H1) and (1-3H1) derivatives were obtained with overall yields (and isotope enrichments) of 11% (min. 84 mol% 2H1) and 8% (60 mCi/mmol), respectively.

  17. 40 CFR 721.10435 - Phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3,3-tetramethylbutyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Phenol, 2-(1-methyl-1-phenylethyl)-4... Significant New Uses for Specific Chemical Substances § 721.10435 Phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3... chemical substance identified as phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3,3-tetramethylbutyl)- (PMN...

  18. 40 CFR 721.10435 - Phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3,3-tetramethylbutyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Phenol, 2-(1-methyl-1-phenylethyl)-4... Significant New Uses for Specific Chemical Substances § 721.10435 Phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3... chemical substance identified as phenol, 2-(1-methyl-1-phenylethyl)-4-(1,1,3,3-tetramethylbutyl)- (PMN...

  19. 26 CFR 1.704-1 - Partner's distributive share.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... §§ 1.704-1T(b)(1)(ii)(b)(1) and 1.704-1T(b)(4)(xi) as in effect prior to October 19, 2006 (see 26 CFR..., see §§ 1.704-1T(b)(1)(ii)(b)(1) and 1.704-1T(b)(4)(xi) as in effect prior to October 19, 2006 (26...

  20. 26 CFR 1.704-1 - Partner's distributive share.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... §§ 1.704-1T(b)(1)(ii)(b)(1) and 1.704-1T(b)(4)(xi) as in effect prior to October 19, 2006 (see 26 CFR..., see §§ 1.704-1T(b)(1)(ii)(b)(1) and 1.704-1T(b)(4)(xi) as in effect prior to October 19, 2006 (26...

  1. CHO cell enlargement oscillates with a temperature-compensated period of 24 min

    NASA Technical Reports Server (NTRS)

    Pogue, R.; Morre, D. M.; Morre, D. J.

    2000-01-01

    The rate of increase in cell area of CHO cells when measured at intervals of 1 min using a light microscope equipped with a video measurement system, oscillated with a minimum period of about 24 min. The pattern of oscillations paralleled those of the 24 min period observed with the oxidation of NADH by an external cell surface or plasma membrane NADH oxidase. The increase in cell area was non-linear. Intervals of rapid increase in area alternated with intervals of rapid decrease in area. The length of the 24 min period was temperature-compensated (approximately the same when measured at 14 degrees C, 24 degrees C or 34 degrees C) while the rate of cell enlargement increased with temperature over this same range of temperatures.

  2. Transient Mesp1 expression

    PubMed Central

    Liu, Yu; Schwartz, Robert J

    2013-01-01

    Mesp1 sits on the tip of the cardiac regulatory hierarchy, recent evidences support that it is regulated by stem cell factor Oct4, early gastrulation signal canonical Wnts and a couple of T-box factors, T and Eomes. With other transcription factors, Mesp1 programs/reprograms human cells toward cardiomyocytes. PMID:23584093

  3. Arginase-1 deficiency.

    PubMed

    Sin, Yuan Yan; Baron, Garrett; Schulze, Andreas; Funk, Colin D

    2015-12-01

    Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ornithine and urea. ARG1-deficient patients exhibit hyperargininemia with spastic paraparesis, progressive neurological and intellectual impairment, persistent growth retardation, and infrequent episodes of hyperammonemia, a clinical pattern that differs strikingly from other urea cycle disorders. This review briefly highlights the current understanding of the etiology and pathophysiology of ARG1 deficiency derived from clinical case reports and therapeutic strategies stretching over several decades and reports on several exciting new developments regarding the pathophysiology of the disorder using ARG1 global and inducible knockout mouse models. Gene transfer studies in these mice are revealing potential therapeutic options that can be exploited in the future. However, caution is advised in extrapolating results since the lethal disease phenotype in mice is much more severe than in humans indicating that the mouse models may not precisely recapitulate human disease etiology. Finally, some of the functions and implications of ARG1 in non-urea cycle activities are considered. Lingering questions and future areas to be addressed relating to the clinical manifestations of ARG1 deficiency in liver and brain are also presented. Hopefully, this review will spark invigorated research efforts that lead to treatments with better clinical outcomes. PMID:26467175

  4. Type 1 Diabetes Facts

    MedlinePlus

    ... rid of it. Whom T1D Affects Type 1 diabetes strikes both children and adults at any age. It comes on suddenly, causes ... their children might develop the disease.” — Nicky Hider, adult, New York CDC National Diabetes Statistics Report, 2014 Impreatore, et al. 2012. Diab ...

  5. Diabetes Type 1

    MedlinePlus

    Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is ... kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults ...

  6. 1,4-Dioxane

    Integrated Risk Information System (IRIS)

    1,4 - Dioxane ; CASRN 123 - 91 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic Eff

  7. 1,3-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,3 - Dichlorobenzene ; CASRN 541 - 73 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinog

  8. 1,2-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,2 - Dichlorobenzene ; CASRN 95 - 50 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  9. A1C

    MedlinePlus

    A1C is a blood test for type 2 diabetes and prediabetes. It measures your average blood glucose, or blood sugar, level over the past 3 ... A1C alone or in combination with other diabetes tests to make a diagnosis. They also use the ...

  10. MIL1A

    Atmospheric Science Data Center

    2014-09-03

    ... MISR Level 1A camera charge-coupled device (CCD) Science Data: Reformatted Annotated Level 1A product of the CCD science data. ... :  Data Product Specification Versioning History:  Ellipsoid, Terrain, Browse, CCD, Radiance SCAR-B ...

  11. Sentinel-1 Instrument Overview

    NASA Astrophysics Data System (ADS)

    Snoeij, Paul; Torres, Ramon; Geudtner, Dirk; Brown, Michael; Deghaye, Patrick; Navas-Traver, Ignacio; Ostergaard, Allan; Rommen, Bjorn; Floury, Nicolas; Davidson, Malcolm

    2013-03-01

    The forthcoming European Space Agency (ESA) Sentinel-1 (S-1) C-band SAR constellation will provide continuous all-weather day/night global coverage, with six days exact repetition time (near daily coverage over Europe and Canada) and with radar data delivery within 3 to 24 hours. These features open new possibilities for operational maritime services. The Sentinel-1 space segment has been designed and is being built by an industrial consortium with Thales Alenia Space Italia as prime contractor and EADS Astrium GmbH as C-SAR instrument responsible. It is expected that Sentinel-1A be launched in 2013. This paper will provide an overview of the Sentinel-1 system, the status and characteristics of the technical implementation. The key elements of the system supporting the maritime user community will be highlighted.

  12. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10

    PubMed Central

    Ramírez, Jacqueline; Mirkov, Snezana; House, Larry K.

    2015-01-01

    OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate the inhibitory potential of OTS167 on UGTs. Formation of a single OTS167-glucuronide (OTS167-G) was observed in pooled human liver (HLM) (Km = 3.4 ± 0.2 µM), intestinal microsomes (HIM) (Km = 1.7 ± 0.1 µM), and UGTs. UGT1A1 (64 µl/min/mg) and UGT1A8 (72 µl/min/mg) exhibited the highest intrinsic clearances (CLint) for OTS167, followed by UGT1A3 (51 µl/min/mg) and UGT1A10 (47 µl/min/mg); UGT1A9 was a minor contributor. OTS167 glucuronidation in HLM was highly correlated with thyroxine glucuronidation (r = 0.91, P < 0.0001), SN-38 glucuronidation (r = 0.79, P < 0.0001), and UGT1A1 mRNA (r = 0.72, P < 0.0001). Nilotinib (UGT1A1 inhibitor) and emodin (UGT1A8 and UGT1A10 inhibitor) exhibited the highest inhibitory effects on OTS167-G formation in HLM (68%) and HIM (47%). We hypothesize that OTS167-G is an N-glucuronide according to mass spectrometry. A significant association was found between rs6706232 and reduced OTS167-G formation (P = 0.03). No or weak UGT inhibition (range: 0–21%) was observed using clinically relevant OTS167 concentrations (0.4–2 µM). We conclude that UGT1A1 and UGT1A3 are the main UGTs responsible for hepatic formation of OTS167-G. Intestinal UGT1A1, UGT1A8, and UGT1A10 may contribute to first-pass OTS167 metabolism after oral administration. PMID:25870101

  13. 26 CFR 1.267(f)-1 - Controlled groups.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... contained in the 26 CFR part 1 edition revised as of April 1, 1995). ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Controlled groups. 1.267(f)-1 Section 1.267(f)-1...) INCOME TAXES Items Not Deductible § 1.267(f)-1 Controlled groups. (a) In general—(1) Purpose....

  14. 26 CFR 1.267(f)-1 - Controlled groups.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... contained in the 26 CFR part 1 edition revised as of April 1, 1995). ... 26 Internal Revenue 3 2011-04-01 2011-04-01 false Controlled groups. 1.267(f)-1 Section 1.267(f)-1...) INCOME TAXES (CONTINUED) Items Not Deductible § 1.267(f)-1 Controlled groups. (a) In general—(1)...

  15. 26 CFR 1.6109-1 - Identifying numbers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., see 26 CFR § 1.6109-1 (revised as of April 1, 1973). ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Identifying numbers. 1.6109-1 Section 1.6109-1...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.6109-1 Identifying numbers. (a) Information to...

  16. 26 CFR 1.6109-1 - Identifying numbers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., see 26 CFR § 1.6109-1 (revised as of April 1, 1973). ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Identifying numbers. 1.6109-1 Section 1.6109-1...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.6109-1 Identifying numbers. (a) Information to...

  17. 26 CFR 1.6109-1 - Identifying numbers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., see 26 CFR § 1.6109-1 (revised as of April 1, 1973). ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Identifying numbers. 1.6109-1 Section 1.6109-1...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.6109-1 Identifying numbers. (a) Information to...

  18. 26 CFR 1.6109-1 - Identifying numbers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., see 26 CFR § 1.6109-1 (revised as of April 1, 1973). ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Identifying numbers. 1.6109-1 Section 1.6109-1...) INCOME TAXES Miscellaneous Provisions § 1.6109-1 Identifying numbers. (a) Information to be...

  19. 26 CFR 1.6109-1 - Identifying numbers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., see 26 CFR § 1.6109-1 (revised as of April 1, 1973). ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Identifying numbers. 1.6109-1 Section 1.6109-1...) INCOME TAXES (CONTINUED) Miscellaneous Provisions § 1.6109-1 Identifying numbers. (a) Information to...

  20. Density functional theory study of SO2-adsorbed Ni(1 1 1) and hydroxylated NiO(1 1 1) surface

    NASA Astrophysics Data System (ADS)

    Wei, Xin; Dong, Chaofang; Chen, Zhanghua; Xiao, Kui; Li, Xiaogang

    2015-11-01

    Spin polarized, DFT + U periodic calculation is used as an effective way to model the adsorption process of SO2 on hydroxylated NiO(1 1 1) surface. The adsorption of atomic O and O2 on the clean Ni(1 1 1) surface is calculated to investigate the forming process of passive film. The molecular and dissociated adsorptions of H2O on NiO(1 1 1) surface are evaluated to construct defect-free hydroxylated NiO(1 1 1) surface. The adsorption of SO2 and atomic O on clean Ni(1 1 1) surface is also investigated to compare with the adsorption capacity between passive film and substrate. With respect to the single adsorption process of SO2 on defect-free hydroxylated NiO(1 1 1) surface, the effects of O vacancy of surface and atomic O closed to the surface are investigated. The calculation results show that there is no chemical adsorption of SO2 on the defect-free hydroxylated NiO(1 1 1) surface with or without atomic O. Either single SO2 or SO2 with atomic O prefer adsorbing on the hydroxylated NiO(1 1 1) surface with O vacancies. The adsorption behavior is strengthened with the increase of percentage of surface O vacancy. The existence of atomic O leads to the production of SO3 on the hydroxylated NiO(1 1 1) surface and strengthens the adsorption capacity of SO2. Furthermore, the results also reveal the relationship between the charge transfer and the adsorption energy of SO2 and atomic O on the hydroxylated NiO(1 1 1) surface and clean Ni(1 1 1) surface. We inferred that broken passive film susceptibility to corrosion compare with substrate when surface O vacancies aggregate and its concentration large enough.

  1. Adsorption of dichlorodifluoromethane, chlorodifluoromethane, chloropentafluoroethane, 1,1-difluoroethane, and 1,1,1,2-tetrafluoroethane on silica gel

    SciTech Connect

    Frere, M.; Berlier, K.; Bougard, J.; Jadot, R. . Service de Thermodynamique)

    1994-10-01

    The CFC's (chlorofluorocarbons) are used as working refrigerants fluids. The most commonly used are R12, R22, and R502 (48.8% R22 and 51.2% R115). Recent concerns of the effects of CFC's on the ozone layer require the development of efficient recovery methods. One technique is to adsorb the fluids onto a porous medium such as silica gel. Thermodynamic data on the adsorption of dichlorodifluoromethane (R12), chlorodifluoromethane (R22), chloropentafluoroethane (R115), 1,1-difluoroethane (R152a), and 1,1,1,2-tetrafluoroethane (R134a) on silica gel are required for the design of recovery units. The results are presented here.

  2. PDZK1 and NHERF1 Regulate the Function of Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) by Modulating Its Subcellular Trafficking and Stability

    PubMed Central

    Zheng, Jian; Chan, Ting; Cheung, Florence Shin Gee; Zhu, Ling; Murray, Michael; Zhou, Fanfan

    2014-01-01

    The human organic anion transporting polypeptide 1A2 (OATP1A2) is an important membrane protein that mediates the cellular influx of various substances including drugs. Previous studies have shown that PDZ-domain containing proteins, especially PDZK1 and NHERF1, regulate the function of related membrane transporters in other mammalian species. This study investigated the role of PDZK1 and NHERF1 in the regulation of OATP1A2 in an in vitro cell model. Transporter function and protein expression were assessed in OATP1A2-transfected HEK-293 cells that co-expressed PDZK1 or NHERF1. Substrate (estrone-3-sulfate) uptake by OATP1A2 was significantly increased to ∼1.6- (PDZK1) and ∼1.8- (NHERF1) fold of control; this was dependent on the putative PDZ-binding domain within the C-terminus of OATP1A2. The functional increase of OATP1A2 following PDZK1 or NHERF1 over-expression was associated with increased transporter expression at the plasma membrane and in the whole cell, and was reflected by an increase in the apparent maximal velocity of estrone-3-sulfate uptake (Vmax: 138.9±4.1 (PDZK1) and 181.4±16.7 (NHERF1) versus 55.5±3.2 pmol*(µg*4 min)−1 in control; P<0.01). Co-immunoprecipitation analysis indicated that the regulatory actions of PDZK1 and NHERF1 were mediated by direct interaction with OATP1A2 protein. In further experiments PDZK1 and NHERF1 modulated OATP1A2 expression by decreasing its internalization in a clathrin-dependent (but caveolin-independent) manner. Additionally, PDZK1 and NHERF1 enhanced the stability of OATP1A2 protein in HEK-293 cells. The present findings indicated that PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability. PMID:24728453

  3. [Sorption Characteristics of Phenanthrene and 1, 1-Dichloroethene onto Reed Straw Biochar in Aquatic Solutions].

    PubMed

    Wu, Qing-wen; Meng, Liang; Zhang, Zhi-hao; Luo, Qi-shi; Yang, Jie

    2016-02-15

    The purpose of this study was to investigate the sorption characteristics of phenanthrene (PHE) and 1, 1-dichloroethene (1, 1-DCE) onto reed straw biochar at 500 degrees C in aquatic solutions. The sorption mechanisms and effects of solution pH and biochar mass on sorption intensity were discussed. The results showed that the time required to reach sorption equilibrium was 60 min and 480 min for PHE and 1, 1-DCE, respectively, with maximum removal rates of 81, 87% and 90.18%. The sorption kinetics of both PHE and 1, 1-DCE fitted the pseudo-second-order model well, but the pseudo-second-order reaction rate of PHE was higher than that of 1, 1-DCE. Furthermore, the sorption processes were controlled by both membrane diffusion and intra-particle diffusion, and the latter was found to be the rate-controlling step. Sorption isotherms of the two organic pollutants fitted well with the Freundlich equation, and the sorption affinity of 1, 1-DCE onto biochar was greater than that of PHE. The total sorption mechanism of biochar was the combination of partition and adsorption, and dominated by adsorption. The adsorption capacity of 1, 1-DCE was greater than that of PHE, but its partition capacity was much smaller, indicating that pollutants' molecular volume and relative polarity would mainly affect the total sorption. Analysis of Fourier transform infrared spectroscopy (FTIR) demonstrated that oxygen- and hydrogen-containing functional groups and pi--pi interaction were important for PHE and 1, 1-DCE sorption onto biochar. The solution pH value had no significant effect on the sorption intensity of PHE and 1, 1-DCE, however, with biochar mass increasing from 5 mg to 50 mg, the equilibrium sorption amount of PHE and 1, 1-DCE decreased by 6.78 times and 2.18 times, and the removal rate increased by 20.21% and 15.78%, respectively. PMID:27363160

  4. An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition

    PubMed Central

    Ondracka, Andrej; Robbins, Jonathan A.; Cross, Frederick R.

    2016-01-01

    B-type cyclin-dependent kinase activity must be turned off for mitotic exit and G1 stabilization. B-type cyclin degradation is mediated by the anaphase-promoting complex/cyclosome (APC/C); during and after mitotic exit, APC/C is dependent on Cdh1. Cdh1 is in turn phosphorylated and inactivated by cyclin-CDK at the Start transition of the new cell cycle. We developed a biosensor to assess the cell cycle dynamics of APC/C-Cdh1. Nuclear exit of the G1 transcriptional repressor Whi5 is a known marker of Start; APC/C-Cdh1 is inactivated 12 min after Whi5 nuclear exit with little measurable cell-to-cell timing variability. Multiple phosphorylation sites on Cdh1 act in a redundant manner to repress its activity. Reducing the number of phosphorylation sites on Cdh1 can to some extent be tolerated for cell viability, but it increases variability in timing of APC/C-Cdh1 inactivation. Mutants with minimal subsets of phosphorylation sites required for viability exhibit striking stochasticity in multiple responses including budding, nuclear division, and APC/C-Cdh1 activity itself. Multiple cyclin-CDK complexes, as well as the stoichiometric inhibitor Acm1, contribute to APC/C-Cdh1 inactivation; this redundant control is likely to promote rapid and reliable APC/C-Cdh1 inactivation immediately following the Start transition. PMID:27410035

  5. The dehydrogenation of CH4 on Rh(1 1 1), Rh(1 1 0) and Rh(1 0 0) surfaces: A density functional theory study

    NASA Astrophysics Data System (ADS)

    Wang, Baojun; Song, Luzhi; Zhang, Riguang

    2012-02-01

    CH4 dehydrogenation on Rh(1 1 1), Rh(1 1 0) and Rh(1 0 0) surfaces has been investigated by using density functional theory (DFT) slab calculations. On the basis of energy analysis, the preferred adsorption sites of CHx (x = 0-4) and H species on Rh(1 1 1), Rh(1 1 0) and Rh(1 0 0) surfaces are located, respectively. Then, the stable co-adsorption configurations of CHx (x = 0-3) and H are obtained. Further, the kinetic results of CH4 dehydrogenation show that on Rh(1 1 1) and Rh(1 0 0) surfaces, CH is the most abundant species for CH4 dissociation; on Rh(1 1 0) surface, CH2 is the most abundant species, our results suggest that Rh catalyst can resist the carbon deposition in the CH4 dehydrogenation. Finally, results of thermodynamic and kinetic show that CH4 dehydrogenation on Rh(1 0 0) surface is the most preferable reaction pathway in comparison with that on Rh(1 1 1) and Rh(1 1 0) surfaces.

  6. 40 CFR 721.10373 - 1H-Imidazole, 1-(1-methylethyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 1H-Imidazole, 1-(1-methylethyl)-. 721... Substances § 721.10373 1H-Imidazole, 1-(1-methylethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1H-imidazole, 1-(1-methylethyl)- (PMN...

  7. 40 CFR 721.10373 - 1H-Imidazole, 1-(1-methylethyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 1H-Imidazole, 1-(1-methylethyl)-. 721... Substances § 721.10373 1H-Imidazole, 1-(1-methylethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1H-imidazole, 1-(1-methylethyl)- (PMN...

  8. 40 CFR 721.10373 - 1H-Imidazole, 1-(1-methylethyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 1H-Imidazole, 1-(1-methylethyl)-. 721... Substances § 721.10373 1H-Imidazole, 1-(1-methylethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1H-imidazole, 1-(1-methylethyl)- (PMN...

  9. A distributed Tier-1

    NASA Astrophysics Data System (ADS)

    Fischer, L.; Grønager, M.; Kleist, J.; Smirnova, O.

    2008-07-01

    The Tier-1 facility operated by the Nordic DataGrid Facility (NDGF) differs significantly from other Tier-1s in several aspects: firstly, it is not located at one or a few premises, but instead is distributed throughout the Nordic countries; secondly, it is not under the governance of a single organization but instead is a meta-center built of resources under the control of a number of different national organizations. We present some technical implications of these aspects as well as the high-level design of this distributed Tier-1. The focus will be on computing services, storage and monitoring.

  10. F-1 Engine Assembly

    NASA Technical Reports Server (NTRS)

    1968-01-01

    A complete F-1 engine assembly is shown in this photograph. Designed and developed by Rocketdye under the direction of the Marshall Space Flight Center, the engine measured 19-feet tall by 12.5 feet at the nozzle exit, and each engine produced a 1,500,000-pound thrust using liquid oxygen and kerosene as the propellant. A cluster of five F-1 engines was mounted on the Saturn V S-IC (first) stage and burned 15 tons of liquid oxygen and kerosene each second to produce 7,500,000 pounds of thrust.

  11. Spacelab Life Sciences-1

    NASA Technical Reports Server (NTRS)

    Dalton, Bonnie P.; Jahns, Gary; Meylor, John; Hawes, Nikki; Fast, Tom N.; Zarow, Greg

    1995-01-01

    This report provides an historical overview of the Spacelab Life Sciences-1 (SLS-1) mission along with the resultant biomaintenance data and investigators' findings. Only the nonhuman elements, developed by Ames Research Center (ARC) researchers, are addressed herein. The STS-40 flight of SLS-1, in June 1991, was the first spacelab flown after 'return to orbit', it was also the first spacelab mission specifically designated as a Life Sciences Spacelab. The experiments performed provided baseline data for both hardware and rodents used in succeeding missions.

  12. Substituted 1,1,1-Triaryl-2,2,2-Trifluoroethanes and processes for their synthesis

    NASA Technical Reports Server (NTRS)

    Alston, William B. (Inventor); Gratz, Roy F. (Inventor)

    1988-01-01

    Synthetic procedures are described for tetraalkyls, tetraacids and dianhydrides substituted 1,1,1-triaryl-2,2,2-trifluoroethanes which comprises: (1) 1,1-bis(dialkylaryl)-1 aryl-2,2,2-trifluoroethane; (2) 1,1-bis(dicarboxyaryl)-1 aryl-2,2,2-trifluoroethane; or (3) cyclic dianhydride or diamine of 1,1-bis(dialkylaryl)-1 aryl-2,2,2,-trifluoroethanes.

  13. Liquid-liquid equilibria for hydrogen fluoride + 1,1-dichloro-1-fluoroethane + 1-chloro-1,1-difluoroethane at {minus}20 and 20 C

    SciTech Connect

    Kang, Y.W.; Lee, Y.Y.

    1995-03-01

    1,1-Dichloro-1-fluoroethane is presently under consideration as a replacement for trichlorofluoromethane, which is widely used as a foam blowing agent. 1-Chloro-1,1-difluoroethane is the major raw material for the production of poly(vinylidene fluoride). These two materials are normally manufactured by the fluorination of 1,1,1-trichloroethane or vinylidene chloride with hydrogen fluoride. A phase separator is normally used to retrieve hydrogen fluoride from the product stream. To design the phase separator, liquid-liquid equilibrium data are required. Liquid-liquid equilibria for the ternary system (hydrogen fluoride + 1,1-dichloro-1-fluoroethane + 1-chloro-1,1-difluoroethane) have been measured at {minus}20 and 20 C. The results are correlated with the NRTL model, and the relevant parameters are presented.

  14. Vitamin B1

    MedlinePlus

    ... Flash 6 » Sound: No High score: Yes Credits » Chicken Farm Game - Why do we need vitamin B1? - ... save lives. You have one minute to feed chickens suffering from beriberi with the correct food to ...

  15. A1C Test

    MedlinePlus

    ... to minimize the complications caused by chronically elevated glucose levels, such as progressive damage to body organs like the kidneys, eyes, cardiovascular system, and nerves. The A1c test result ...

  16. Thiamine (Vitamin B1)

    MedlinePlus

    ... B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin ... in appropriate amounts, although rare allergic reactions and skin irritation have occurred. It is also LIKELY SAFE ...

  17. PBT-1 Prana Biotechnology.

    PubMed

    Huckle, Richard

    2005-01-01

    PBT-1 (clioquinol), is undergoing phase II clinical trials by Prana Biotechnology Ltd for the potential treatment of Alzheimer's disease. By October 2004, the company had planned phase III trials for the first half of 2005. PMID:15675609

  18. Type 1 diabetes

    PubMed Central

    Atkinson, Mark A; Eisenbarth, George S; Michels, Aaron W

    2015-01-01

    Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease. PMID:23890997

  19. Chapter 1: Introduction

    SciTech Connect

    None, None

    2009-01-18

    This report describes analysis undertaken by EERE to better understand the extent to which the technologies and market improvements funded by its fiscal year (FY) 2006 Budget Request1 will make energy more affordable, cleaner, and more reliable.

  20. Child with NF1

    MedlinePlus

    ... disorder. Such discoveries have already resulted in new methods of diagnosis. The likelihood of finding effective treatments for NF1, in the years ahead, is promising. Scientists are actively researching the disorder at centers throughout ...