Science.gov

Sample records for 1 5 10

  1. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  2. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  3. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  4. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  5. 5 CFR 10.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES AGENCY ACCOUNTABILITY SYSTEMS; OPM AUTHORITY TO REVIEW PERSONNEL MANAGEMENT PROGRAMS (RULE X) § 10.1 Definitions. For purposes of this rule— (a... personnel management that are set forth in section 2301(b) of title 5, United States Code....

  6. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  7. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  8. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  9. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  10. 1 CFR 5.10 - Forms of publication.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Forms of publication. 5.10 Section 5.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.10 Forms of publication. Pursuant to section 1506 of title 44, United States Code, the Administrative Committee...

  11. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5-1 System guidelines. (a) Qualifying conditions—(1)...

  12. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5-1 System guidelines. (a) Qualifying conditions—(1)...

  13. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5-1 System guidelines. (a) Qualifying conditions—(1)...

  14. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5-1 System guidelines. (a) Qualifying conditions—(1)...

  15. 10 CFR 960.5-1 - System guidelines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false System guidelines. 960.5-1 Section 960.5-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5-1 System guidelines. (a) Qualifying conditions—(1)...

  16. Spectroscopy study of 5-amino-1,10-phenanthroline.

    PubMed

    Ramírez-Silva, Ma Teresa; Gómez-Hernández, Martín; Pacheco-Hernández, Ma Lourdes; Rojas-Hernández, Alberto; Galicia, Laura

    2004-03-01

    Acidity constants for the 5-amino-1,10-phenanthroline (5-Aphen) were determined in aqueous media, using SQUAD and SUPERQUAD programs. Spectrophotometry and potentiometry data were fitted to the best model to enable correlation of the following acidity equilibria: 5-AphenH = 5-Aphen + H+ (-log K = 5.78 +/= 0.03) and 5-AphenH2 = 5-AphenH2 = 5-Aphen + 2H+ (-log K = 6.89 +/= 0.07). UV absorptivity coefficients obtained suggest that the first protonation takes place on the nitrogens of the heterocycle ring and the second protonation could take place on the amino group. As expected, the electrochemical evidence of the 5-Aphen species depends on the degree of protonation.

  17. Spectroscopy study of 5-amino-1,10-phenanthroline

    NASA Astrophysics Data System (ADS)

    Ramírez-Silva, Ma. Teresa; Gómez-Hernández, Martín.; Pacheco-Hernández, Ma de Lourdes; Rojas-Hernández, Alberto; Galicia, Laura

    2004-03-01

    Acidity constants for the 5-amino-1,10-phenanthroline (5-Aphen) were determined in aqueous media, using SQUAD and SUPERQUAD programs. Spectrophotometry and potentiometry data were fitted to the best model to enable correlation of the following acidity equilibria: 5-AphenH=5-Aphen+H + (- log K=5.78±0.03 ) and 5-AphenH 2=5-Aphen+2H + (- log K=6.89±0.07 ). UV absorptivity coefficients obtained suggest that the first protonation takes place on the nitrogens of the heterocycle ring and the second protonation could take place on the amino group. As expected, the electrochemical evidence of the 5-Aphen species depends on the degree of protonation.

  18. 1-(5,5-Dioxido-10H-phenothia­zin-10-yl)ethanone

    PubMed Central

    Siddegowda, M. S.; Jasinski, Jerry P.; Golen, James A.; Yathirajan, H. S.

    2011-01-01

    In the title compound, C14H11NO3S, the six-membered thia­zine ring fused to two benzene rings adopts a distorted boat conformation. The dihedral angle between the mean planes of the two benzene rings is 45.8 (1)°. The crystal packing is stabilized by weak inter­molecular C—H⋯O inter­actions. PMID:21837098

  19. 32 CFR 1636.5 - Exclusion from Class 1-A-0 and Class 1-0.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CLASSIFICATION OF CONSCIENTIOUS OBJECTORS § 1636.5 Exclusion from Class 1-A-0 and Class 1-0. A registrant shall... any form (a selective objection). If a registrant objects to war in any form, but also believes in...

  20. Crystal structure and anomalous chemical shift of 10-(prop-1-yn-1-yl)-10H-phenothiazine 5,5-dioxide: Intramolecular S⋯N transannular effect

    NASA Astrophysics Data System (ADS)

    Umezono, Satoru; Okuno, Tsunehisa

    2013-10-01

    The novel ynamine compounds, 10-(prop-1-yn-1-yl)-10H-phenothiazine 5-oxide (2) and 10-(prop-1-yn-1-yl)-10H-phenothiazine 5,5-dioxide (3), were prepared by MCPBA oxidation of 10-(prop-1-yn-1-yl)-10H-phenothiazine (1). These compounds were characterized successfully by crystallographical analyses, 1H and 13C NMR. The 1H NMR signals of 2 showed downfield shifts compared with 1 as expected. However two kinds of signals, methyl and 1,9-position of 3, indicated upfield shifts compared with 2. These anomalous upfield shifts were reasonably explained by trans-annular S⋯N interaction and by increase of electron density on the nitrogen atom.

  1. Introgression of 1Dx5+1Dy10 into tritordeum.

    PubMed

    Ballesteros, J; Alvarez, J B; Giménez, M J; Ramírez, M C; Cabrera, A; Martín, A

    2003-02-01

    The uses of hexaploid tritordeum as a crop for human consumption require improvement of its bread-making quality. For this purpose chromosome 1D of bread wheat with the Glu-D1 allele encoding for high-molecular-weight glutenin subunits Dx5+Dy10 was introgressed into tritordeum. Different primary tritordeums were crossed with wheats carrying subunits Dx5+Dy10. The hybrids were backcrossed to tritordeum and seeds for the next backcross (or selfing) were selected for the presence of chromosome 1D using SDS-PAGE. Forty two chromosome plants carrying subunits Dx5+Dy10 were obtained after two backcrosses and selfing. Chromosome characterization of these plants using fluorescence in situ hybridisation (FISH) proved that either chromosome substitution 1H(ch)/1D or 1A/1D had been obtained. A homozygous plant with a translocation of the entire 1DL arm to 1H(ch)S was also obtained. The complete chromosome substitution lines have better agronomic characteristics than the lines with translocations.

  2. 46 CFR 56.35-10 - Nonmetallic expansion joints (replaces 119.5.1).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Nonmetallic expansion joints (replaces 119.5.1). 56.35... ENGINEERING PIPING SYSTEMS AND APPURTENANCES Expansion, Flexibility and Supports § 56.35-10 Nonmetallic expansion joints (replaces 119.5.1). (a) Nonmetallic expansion joints certified in accordance with...

  3. 46 CFR 56.35-10 - Nonmetallic expansion joints (replaces 119.5.1).

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Nonmetallic expansion joints (replaces 119.5.1). 56.35... ENGINEERING PIPING SYSTEMS AND APPURTENANCES Expansion, Flexibility and Supports § 56.35-10 Nonmetallic expansion joints (replaces 119.5.1). (a) Nonmetallic expansion joints certified in accordance with...

  4. 46 CFR 56.35-10 - Nonmetallic expansion joints (replaces 119.5.1).

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Nonmetallic expansion joints (replaces 119.5.1). 56.35... ENGINEERING PIPING SYSTEMS AND APPURTENANCES Expansion, Flexibility and Supports § 56.35-10 Nonmetallic expansion joints (replaces 119.5.1). (a) Nonmetallic expansion joints certified in accordance with...

  5. 46 CFR 56.35-10 - Nonmetallic expansion joints (replaces 119.5.1).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Nonmetallic expansion joints (replaces 119.5.1). 56.35... ENGINEERING PIPING SYSTEMS AND APPURTENANCES Expansion, Flexibility and Supports § 56.35-10 Nonmetallic expansion joints (replaces 119.5.1). (a) Nonmetallic expansion joints certified in accordance with...

  6. 46 CFR 56.35-10 - Nonmetallic expansion joints (replaces 119.5.1).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Nonmetallic expansion joints (replaces 119.5.1). 56.35... ENGINEERING PIPING SYSTEMS AND APPURTENANCES Expansion, Flexibility and Supports § 56.35-10 Nonmetallic expansion joints (replaces 119.5.1). (a) Nonmetallic expansion joints certified in accordance with...

  7. RealGasBrine v1.0 option of TOUGH+ v1.5

    SciTech Connect

    Moridis, George

    2015-02-27

    RealGasBrine v1.0 is a numerical code that for the simulation of the behavior of gas-bearing porous and/fractured geologic media. It is an option of TOUGH+ v1.5 [Moridis, 2014], a successor to the TOUGH2 [Pruess et al., 1999; 2012] family of codes for multi-component, multiphase ?uid and heat ?ow developed at the Lawrence Berkeley National Laboratory. RealGasBrine v1.0 needs the TOUGH+ v1.5 core code in order to compile and execute. It is written in standard FORTRAN 95/2003, and can be run on any computational platform (workstation, PC, Macintosh) for which such compilers are available. RealGasBrine v1.0 describes the non-isothermal two- (for pure water) or three-phase (for brine) flow of an aqueous phase and a real gas mixture in a gas-bearing medium, with a particular focus in ultra-tight (such as tight-sand and shale gas) systems. Up to 12 individual real gases can be tracked, and salt can precipitate as solid halite. The capabilities of the code include coupled flow and thermal effects, real gas behavior, Darcy and non-Darcy flow, several isotherm options of gas sorption onto the grains of the porous media, complex fracture descriptions, gas solubility into water, and geomechanical effects on flow properties. RealGasBrine v1.0 allows the study of flow and transport of fluids and heat over a wide range of time frames and spatial scales not only in gas reservoirs, but also in any problem involving the flow of gases in geologic media, including the geologic storage of greenhouse gas mixtures, the behavior of geothermal reservoirs with multi-component condensable (H2O and CO2) and non-condensable gas mixtures, the transport of water and released H2 in nuclear waste storage applications, etc.

  8. 33 CFR 66.10-5-66.10-10 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false 66.10-5-66.10-10 Section 66.10-5-66.10-10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Uniform State Waterway Marking System §§ 66.10-5—66.10-10...

  9. 33 CFR 66.10-5-66.10-10 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false 66.10-5-66.10-10 Section 66.10-5-66.10-10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION PRIVATE AIDS TO NAVIGATION Uniform State Waterway Marking System §§ 66.10-5—66.10-10...

  10. 10 CFR 960.5-2-1 - Population density and distribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Population density and distribution. 960.5-2-1 Section 960... Population density and distribution. (a) Qualifying condition. The site shall be located such that, during... specified in § 960.5-1(a)(1). (b) Favorable conditions. (1) A low population density in the general...

  11. 10 CFR 960.5-2-1 - Population density and distribution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Population density and distribution. 960.5-2-1 Section 960... Population density and distribution. (a) Qualifying condition. The site shall be located such that, during... specified in § 960.5-1(a)(1). (b) Favorable conditions. (1) A low population density in the general...

  12. 10 CFR 960.5-2-1 - Population density and distribution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Population density and distribution. 960.5-2-1 Section 960... Population density and distribution. (a) Qualifying condition. The site shall be located such that, during... specified in § 960.5-1(a)(1). (b) Favorable conditions. (1) A low population density in the general...

  13. 10 CFR 960.5-2-1 - Population density and distribution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Population density and distribution. 960.5-2-1 Section 960... Population density and distribution. (a) Qualifying condition. The site shall be located such that, during... specified in § 960.5-1(a)(1). (b) Favorable conditions. (1) A low population density in the general...

  14. 10 CFR 960.5-2-1 - Population density and distribution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Population density and distribution. 960.5-2-1 Section 960... Population density and distribution. (a) Qualifying condition. The site shall be located such that, during... specified in § 960.5-1(a)(1). (b) Favorable conditions. (1) A low population density in the general...

  15. 10 CFR 10.5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Definitions. 10.5 Section 10.5 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.5 Definitions. Access...

  16. 10 CFR 10.5 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 10.5 Section 10.5 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.5 Definitions. Access...

  17. 10 CFR 10.5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Definitions. 10.5 Section 10.5 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.5 Definitions. Access...

  18. 10 CFR 10.5 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Definitions. 10.5 Section 10.5 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.5 Definitions. Access...

  19. 10 CFR 10.5 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Definitions. 10.5 Section 10.5 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.5 Definitions. Access...

  20. 32 CFR 1636.5 - Exclusion from Class 1-A-0 and Class 1-0.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... be excluded from Class 1-A-0 or Class 1-0: (a) Who asserts beliefs which are of a religious, moral or... participation in war does not rest at all upon moral, ethical, or religious principle, but instead rests...

  1. 10 CFR 960.3-1-5 - Basis for site evaluations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Basis for site evaluations. 960.3-1-5 Section 960.3-1-5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A... understanding of the potential effects of engineered barriers on the overall performance of the...

  2. 32 CFR 1636.5 - Exclusion from Class 1-A-0 and Class 1-0.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... be excluded from Class 1-A-0 or Class 1-0: (a) Who asserts beliefs which are of a religious, moral or... participation in war does not rest at all upon moral, ethical, or religious principle, but instead rests solely... theocratic, spiritual war between the forces of good and evil, he may not by reason of that belief alone...

  3. Acetato(1,10-phenanthroline-5,6-dione)silver(I) trihydrate

    PubMed Central

    Onuegbu, Jonathan; Butcher, Ray J.; Hosten, Charles; Udeochu, Uche Charles; Bakare, Oladapo

    2008-01-01

    In the structure of the title compound, [Ag(C2H3O2)(C12H6N2O2)]·3H2O, the AgI atom is coordinated by both 1,10-phenanthroline-5,6-dione N atoms and one O atom from the acetate anion. The three water mol­ecules are involved in extensive hydrogen bonding to each other and to the acetate O and 1,10-phenanthroline-5,6-dione O atoms. In addition, there are weak C—H⋯O inter­actions. PMID:21201351

  4. Single mode operation with mid-IR hollow fibers in the range 5.1-10.5 µm.

    PubMed

    Sampaolo, Angelo; Patimisco, Pietro; Kriesel, Jason M; Tittel, Frank K; Scamarcio, Gaetano; Spagnolo, Vincenzo

    2015-01-12

    Single mode beam delivery in the mid-infrared spectral range 5.1-10.5 μm employing flexible hollow glass waveguides of 15 cm and 50 cm lengths, with metallic/dielectric internal layers and a bore diameter of 200 μm were demonstrated. Three quantum cascade lasers were coupled with the hollow core fibers. For a fiber length of 15 cm, we measured losses down to 1.55 dB at 5.4 μm and 0.9 dB at 10.5 μm. The influence of the launch conditions in the fiber on the propagation losses and on the beam profile at the waveguide exit was analyzed. At 10.5 µm laser wavelength we found near perfect agreement between measured and theoretical losses, while at ~5 µm and ~6 µm wavelengths the losses were higher than expected. This discrepancy can be explained considering an additional scattering loss effect, which scales as 1/λ(2) and is due to surface roughness of the metallic layer used to form the high-reflective internal layer structure of the hollow core waveguide.

  5. 33 CFR 1.10-5 - Public availability of records and documents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... written request to the Chief, Office of Information Management (CG-61), U.S. Coast Guard Headquarters... of Information Management (CG-61), at the address in paragraph (a) of this section. ... HOMELAND SECURITY GENERAL GENERAL PROVISIONS Public Availability of Information § 1.10-5...

  6. 33 CFR 1.10-5 - Public availability of records and documents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... written request to the Chief, Office of Information Management (CG-61), U.S. Coast Guard Headquarters... of Information Management (CG-61), at the address in paragraph (a) of this section. ... HOMELAND SECURITY GENERAL GENERAL PROVISIONS Public Availability of Information § 1.10-5...

  7. 33 CFR 1.10-5 - Public availability of records and documents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... written request to the Chief, Office of Information Management (CG-61), U.S. Coast Guard Headquarters... of Information Management (CG-61), at the address in paragraph (a) of this section. ... HOMELAND SECURITY GENERAL GENERAL PROVISIONS Public Availability of Information § 1.10-5...

  8. 33 CFR 1.10-5 - Public availability of records and documents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... written request to the Chief, Office of Information Management (CG-61), U.S. Coast Guard Headquarters... of Information Management (CG-61), at the address in paragraph (a) of this section. ... HOMELAND SECURITY GENERAL GENERAL PROVISIONS Public Availability of Information § 1.10-5...

  9. 33 CFR 1.10-5 - Public availability of records and documents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... written request to the Chief, Office of Information Management (CG-61), U.S. Coast Guard Headquarters... of Information Management (CG-61), at the address in paragraph (a) of this section. ... HOMELAND SECURITY GENERAL GENERAL PROVISIONS Public Availability of Information § 1.10-5...

  10. Software Design Document Vehicle Simulation CSCI (5). Volume 1. Sections 1.0 - 2.2.3.1

    DTIC Science & Technology

    1991-06-01

    169 2.1.2.2.2.14.4 storeroundfired ........................ 170 2.1.2.2.2.14.5 store_viewmagnification ........... 171 x BBN Systems and...1330 2.6.1.4.2 allocate- x -powers .............. 1331 2.6.1.4.3 allocate-y-.powers .............. 1332 2.6.1.4.4 allocate-sim-lin-eq...1332 2.6.1.4.5 generate x -powers.............. 1333 2.6.1.4.6 generate..y-powers.............. 1333 2.6.1.4.7 generate-simjlineq

  11. 46 CFR 56.30-10 - Flanged joints (modifies 104.5.1(a)).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... on the flange for the full circumference as close as possible to the fillet of the flange. The number...-10 (b), Method 8. Welding neck flanges may be used on any piping provided the flanges are butt-welded..., refer to 46 CFR 56.30-5(b) for requirements. (9) Figure 56.30-10 (b), Method 9. Welding neck flanges...

  12. Bis(6-nitro-1,10-phenanthrolin-1-ium) 2,5-di-carb-oxy-terephthalate.

    PubMed

    Zhong, Kai-Long; Ni, Chao

    2014-03-01

    In the structure of the title 2:1 proton-transfer compound, 2C12H8N3O2 (+)·C10H4O8 (2-), the 6-nitro-1,10-phenanthroline mol-ecules act as proton sponges, accepting protons from pyromellitic acid. The -NO2 group of one of the 6-nitro-1,10-phenanthrolin-1-ium cations is disordered and was refined with a site-occupancy ratio of 0.624 (15):0.376 (15). Two -COOH(-COO(-)) groups of the 2,5-di-carb-oxy-terephthalate dianion are disordered and were refined with site-occupancy ratios of 0.769 (4):0.231 (4) and 0.766 (5):0.234 (5). The -NO2 group of the second cation is also disordered about a pseudo-twofold rotation axis and was refined with a site-occupancy ratio of 0.903 (3):0.097 (3). There is an intra-molecular O-H⋯O hydrogen bond in the anion. The phenanthroline rings of the two cations are inclined to one another by 31.3 (1)°. In the anions, considering the major components only, the carb-oxy-lic acid groups (-COOH) are inclined to the benzene ring by 17.3 (2) and 22.3 (3)°. The carboxyl-ate groups (-COO(-)) are twisted by 9.3 (2) and 13.6 (6)° with respect to the benzene ring. In the crystal, adjacent 2,5-di-carb-oxy-terephthalate anions are linked via O-H⋯O hydrogen bonds, forming chains propagating along [010]. The cations are attached to the chain of anions by N-H⋯O hydrogen bonds.

  13. 78 FR 14095 - Determination That GEREF (Sermorelin Acetate) Injection, 0.5 Milligrams Base/Vial and 1.0...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... (Sermorelin Acetate) ] injection, 0.5 milligrams (mg) base/vial and 1.0 mg base/vial, and GEREF (Sermorelin Acetate) injection, 0.05 mg base/amp, were not withdrawn from sale for reasons of safety or effectiveness... (Sermorelin Acetate) injection, 0.5 mg base/vial and 1.0 mg base/vial, and GEREF (Sermorelin...

  14. Bis(6-nitro-1,10-phenanthrolin-1-ium) 2,5-di­carb­oxy­terephthalate

    PubMed Central

    Zhong, Kai-Long; Ni, Chao

    2014-01-01

    In the structure of the title 2:1 proton-transfer compound, 2C12H8N3O2 +·C10H4O8 2−, the 6-nitro-1,10-phenanthroline mol­ecules act as proton sponges, accepting protons from pyromellitic acid. The –NO2 group of one of the 6-nitro-1,10-phenanthrolin-1-ium cations is disordered and was refined with a site-occupancy ratio of 0.624 (15):0.376 (15). Two –COOH(–COO−) groups of the 2,5-di­carb­oxy­terephthalate dianion are disordered and were refined with site-occupancy ratios of 0.769 (4):0.231 (4) and 0.766 (5):0.234 (5). The –NO2 group of the second cation is also disordered about a pseudo-twofold rotation axis and was refined with a site-occupancy ratio of 0.903 (3):0.097 (3). There is an intra­molecular O—H⋯O hydrogen bond in the anion. The phenanthroline rings of the two cations are inclined to one another by 31.3 (1)°. In the anions, considering the major components only, the carb­oxy­lic acid groups (–COOH) are inclined to the benzene ring by 17.3 (2) and 22.3 (3)°. The carboxyl­ate groups (–COO−) are twisted by 9.3 (2) and 13.6 (6)° with respect to the benzene ring. In the crystal, adjacent 2,5-di­carb­oxy­terephthalate anions are linked via O—H⋯O hydrogen bonds, forming chains propagating along [010]. The cations are attached to the chain of anions by N—H⋯O hydrogen bonds. PMID:24764973

  15. Attenuation of Cardiovascular Response with Lidocaine 1.5 mg/kg and Labetalol 10 mg

    DTIC Science & Technology

    1990-07-01

    5 ug/ml). Low dose 7 IV Lidocaine has been demonstrated to decrease opioid requirements for post operative pain , and also has been shown to reduce...means of alleviating acute and chronic pain . As adjuncts to general anesthesia, infusions of lidocaine have been used to supplement thiopental and...REPORIV DOC~UMENTAT;O(.)N PAGE - - Ir . . . .. .. . . . . . . - 1990 THESISiEGGEREMM Attenuation of Cardiovascular Response with Lidocaine N 1.5 mg

  16. 76 FR 52215 - Airworthiness Directives; General Electric Company CF34-10E2A1; CF34-10E5; CF34-10E5A1; CF34-10E6...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Electric Company CF34-10E turbofan engine experiencing high fan frame vibrations led to removal of the fan...-07-AD; Amendment 39-16784; AD 2011-18-02] RIN 2120-AA64 Airworthiness Directives; General Electric... Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting...

  17. RGUI 1.0, New Graphical User Interface for RELAP5-3D

    SciTech Connect

    Mesina, George Lee; Galbraith, James Andrew

    1999-04-01

    With the advent of three-dimensional modeling in nuclear safety analysis codes, the need has arisen for a new display methodology. Currently, analysts either sort through voluminous numerical displays of data at points in a region, or view color coded interpretations of the data on a two-dimensional rendition of the plant. RGUI 1.0 provides 3D capability for displaying data. The 3D isometric hydrodynamic image is built automatically from the input deck without additional input from the user. Standard view change features allow the user to focus on only the important data. Familiar features that are standard to the nuclear industry, such as run, interact, and monitor, are included. RGUI 1.0 reduces the difficulty of analyzing complex three dimensional plants.

  18. RGUI 1.0, New Graphical User Interface for RELAP5-3D

    SciTech Connect

    G. L. Mesina; J. Galbraith

    1999-04-01

    With the advent of three-dimensional modeling in nuclear safety analysis codes, the need has arisen for a new display methodology. Currently, analysts either sort through voluminous numerical displays of data at points in a region, or view color coded interpretations of the data on a two-dimensional rendition of the plant. RGUI 1.0 provides 3D capability for displaying data. The 3D isometric hydrodynamic image is built automatically from the input deck without additional input from the user. Standard view change features allow the user to focus on only the important data. Familiar features that are standard to the nuclear industry, such as run, interact, and monitor, are included. RGUI 1.0 reduces the difficulty of analyzing complex three-dimensional plants.

  19. 46 CFR 56.30-10 - Flanged joints (modifies 104.5.1(a)).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... limited to a maximum of 0.525 inch instead of 1.4T. (3) Figure 56.30-10(b), Method 3. Slip-on flanges..., diameter, wall thickness, and material of the pipe being joined, then slip-on flanges are not permitted and... may be a maximum of three-eighths of an inch. Restrictions on the use of slip-on flanges appear in...

  20. 46 CFR 56.30-10 - Flanged joints (modifies 104.5.1(a)).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... limited to a maximum of 0.525 inch instead of 1.4T. (3) Figure 56.30-10(b), Method 3. Slip-on flanges..., diameter, wall thickness, and material of the pipe being joined, then slip-on flanges are not permitted and... may be a maximum of three-eighths of an inch. Restrictions on the use of slip-on flanges appear in...

  1. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    DOEpatents

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  2. Toxicity of firemaster FF-1 and 2,2',4,4',5,5'-hexabromobiphenyl in cultures of C3H/10T 1/2 mammalian fibroblasts.

    PubMed

    Bairstow, F; Hsia, M T; Norback, D H; Allen, J R

    1978-04-01

    A procedure for purifying 2,2', 4,4',5,5'-hexabromobiphenyl (HBB) from FireMaster FF-1 in gram amounts by crystallization is presented. Following purification, the structural assignment of HBB was made by using proton and carbon-13 nuclear magnetic resonance (NMR) spectroscopy, elemental analysis, and mass spectroscopy (MS). The growth of C3H/10T 1/2 cells treated with 5, 37, 75, and 150 microgram of HBB and FF-1 per milliliter of medium was measured at 4, 8, and 13 days following treatment. FF-1 was more toxic at 37 and 75 microgram/ml at both 4 and 8 days, but the same at 13 days. At 150 microgram/ml cell growth was completely inhibited by both compounds. Growth of cells was stimulated at 5 microgram/ml, by HBB at 4 and 8 days, and FF-1 at 8 and 12 days. HCB was compared with HBB and FF-1 for cell growth toxicity at 37 and 75 microgram/ml. At 75 microgram/ml, HCB was more toxic than HBB and FF-1 during the entire time period. At 37 microgram/ml, HCB was more toxic than HBB and FF-1 at 4 and 8 days. Cells seeded at high densities and treated with HBB for three days lost the high degree of postconfluence inhibition of cell division observed in control cultures. Cells treated with FF-1 for three days did not adhere well to the plastic growth surface. Ultrastructural features of the HBB- and FF-1-treated cells included decreased surface villi and increased lysosomes relative to the control cells.

  3. 21 CFR 73.3118 - N,N′-(9,10-Dihydro-9,10-dioxo-1,5-anthracenediyl) bisbenzamide.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false N,Nâ²-(9,10-Dihydro-9,10-dioxo-1,5-anthracenediyl) bisbenzamide. 73.3118 Section 73.3118 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... accomplish the intended coloring effect. (2) Authorization for this use shall not be construed as waiving...

  4. 21 CFR 73.3118 - N,N′-(9,10-Dihydro-9,10-dioxo-1,5-anthracenediyl) bisbenzamide.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false N,Nâ²-(9,10-Dihydro-9,10-dioxo-1,5-anthracenediyl) bisbenzamide. 73.3118 Section 73.3118 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... accomplish the intended coloring effect. (2) Authorization for this use shall not be construed as waiving...

  5. Microstructure of Hot Rolled 1.0C-1.5Cr Bearing Steel and Subsequent Spheroidization Annealing

    NASA Astrophysics Data System (ADS)

    Li, Zhen-Xing; Li, Chang-Sheng; Zhang, Jian; Li, Bin-Zhou; Pang, Xue-Dong

    2016-07-01

    The effect of final rolling temperature and cooling process on the microstructure of 1.0C-1.5Cr bearing steel was studied, and the relationship between the microstructure parameters and subsequent spheroidization annealing was analyzed. The results indicate that the increase of water-cooling rate after hot rolling and the decrease of final cooling temperature are beneficial to reducing both the pearlite interlamellar spacing and pearlite colony size. Prior austenite grain size can be reduced by decreasing the final rolling temperature and increasing the water-cooling rate. When the final rolling temperature was controlled around 1103 K (830 °C), the subsequent cooling rate was set to 10 K/s and final cooling temperature was 953 K (680 °C), the precipitation of grain boundary cementite was suppressed effectively and lots of rod-like cementite particles were observed in the microstructure. Interrupted quenching was employed to study the dissolution behavior of cementite during the austenitizing at 1073 K (800 °C). The decrease of both pearlite interlamellar spacing and pearlite colony size could facilitate the initial dissolution and fragmentation of cementite lamellae, which could shorten the spheroidization time. The fragmentation of grain boundary cementite tends to form large-size undissolved cementite particles. With the increase of austenitizing time from 20 to 300 minutes, mean diameter of undissolved cementite particles increases, indicating the cementite particle coarsening and cementite dissolution occuring simultaneously. Mean diameter of cementite particles in the final spheroidized microstructure is proportional to the mean diameter of undissolved cementite particles formed during partial austenitizing.

  6. A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol.

    PubMed

    Liu, Danyang; Dijkstra, Durk; de Vries, Jan B; Wikström, Håkan V

    2008-03-15

    Previously, we have demonstrated that enone prodrugs of dopaminergic catecholamines represent a new type of dopamine (DA) agonist. Trans-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol (TL-334), the active form of trans-1-propyl-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo[g]quinolin-6-one (GMC-6650), in vivo showed an extremely potent dopaminergic activity. Here, we report a novel synthesis and a pharmacological evaluation of TL-334 by means of microdialysis.

  7. Synthesis of CeFe10.5Mo1.5 with ThMn12-type structure by melt spinning

    SciTech Connect

    Zhou, C; Tessema, M; Meyer, MS; Pinkerton, FE

    2013-06-01

    Rare earth compounds RFe12_xMx with tetragonal ThMn12-type structure are of great research interest for potential applications as permanent magnets. These materials are known to serve as the precursors for nitriding and hydriding processes which in certain conditions can dramatically increase the Curie temperature, spontaneous magnetization, and affect the magnetic anisotropy. In this paper, we report the phase study of CeFe10.5Mo1.5 samples melt spun at various surface wheel speeds vs between 5 m/s and 60 m/s. The results from quantitative Rietveld analysis indicate that the as-spun ribbons are a mixture of primary CeFe10.5Mo1.5 phase with impurity phases such as Ce2Fe17, Fe-Mo alloy and CeFe2. When the wheel speed vs is below 25 m/s, CeFe10.5Mo1.5 phase accounts for greater than 85 wt% in the as-spun ribbons, while the Fe-Mo alloy is the only detectable impurity phase. Above v(s)=25 m/s, as the wheel speed increases, CeFe10.5Mo1.5 phase decreases monotonically to about 60 wt% at v(s)=6O m/s while the amounts of impurity phases increase. Thermogravimetric measurement indicates that the Curie temperature T-c. corresponding to CeFe10.5Mo1.5 phase is 341 K. As a result, the best performing sample melt spun at v(s),=15 m/s only exhibits an energy product BHmax=0.121 MGOe at room temperature. Although such a number is modest for a permanent magnet, further nitriding is expected to greatly enhance the Curie temperature, and hence the magnetic performance. (C) 2013 Elsevier B.V. All rights reserved.

  8. Phase purity and superconductivity of ruthenocuprates RuySr2Gd1.5Ce0.5Cu2O10

    NASA Astrophysics Data System (ADS)

    Hata, Y.; Uragami, Y.; Yasuoka, H.

    2008-12-01

    RuySr2Gd1.5Ce0.5Cu2O10-δ (y = 0.9, 0.95, 1.0, 1.05 and 1.1) were synthesized by a solid-state reaction. The phase purity of the specimens was examined by X-ray powder diffraction and their superconductivity was confirmed by resistivity measurements. All the specimens exhibited superconductivity and contained small amounts of impurity phases of SrRuO3 , Sr2RuGdO3 and RuSr2GdCu2O8 . Ru1.1Sr2Gd1.5Ce0.5Cu2O10-δ contained the least amount of impurities and had the highest superconducting transition temperature. Two magnetic transitions were observed at 128 and 88.5 K in both the dc magnetization measurements and the ac susceptibility measurements. It is concluded that the former transition originates from the weak ferromagnetic transition of RuSr2GdCu2O8 and the latter transition corresponds to the weak ferromagnetic transition of Ru ions in Ru1.1Sr2Gd1.5Ce0.5Cu2O10-δ . The isothermal magnetization curve was derived from fundamental and higher-harmonic complex susceptibility measurements. The magnetization curve consists of a hysteresisless diamagnetism component and a component that is typical for magnetization of the mixed state in a type-II superconductor. The former is due to intragrain superconductivity and the latter is due to intergrain superconductivity. The intergrain critical current density at 5 K is estimated to be 0.75A /cm2 and it is several orders of magnitude lower than that of the ceramic YBa2Cu3O7-δ .

  9. Phase diagram of the selenium-sulfur system in the pressure range 1 × 10-5-1 × 10-1 MPa

    NASA Astrophysics Data System (ADS)

    Volodin, V. N.; Burabaeva, N. M.; Trebukhov, S. A.; Ersaiynova, A. A.

    2016-11-01

    The partial pressures of the components in the saturated vapor of the Se-S system were determined and presented as the temperature-concentration dependences. Based on these data, the boundaries of the melt-vapor phase transition at atmospheric pressure and in vacuum (1350, 100, and 10 Pa) were calculated. A complete phase diagram was constructed, which included the vapor-liquid equilibrium fields at atmospheric and low pressures, whose boundaries allowed us to determine the behavior of sulfur and selenium during distillation separation.

  10. 10 CFR 1.5 - Location of principal offices and regional offices.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... offices in the Washington, DC, area are as follows: (1) One White Flint North Building, 11555 Rockville... addresses of the NRC Regional Offices are as follows: (1) Region 1, USNRC, 475 Allendale Road, King of Prussia, PA 19406-1415. (2) Region II, USNRC, 245 Peachtree Center Avenue, NE., Suite 1200, Atlanta,...

  11. 10 CFR 1.5 - Location of principal offices and Regional Offices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... offices in the Washington, DC, area are as follows: (1) One White Flint North Building, 11555 Rockville... addresses of the NRC Regional Offices are as follows: (1) Region 1, USNRC, 475 Allendale Road, King of...., Suite 23 T85, Atlanta, GA 30303-8931. (3) Region III, USNRC, 2443 Warrenville Road, Suite 210, Lisle,...

  12. Anticonvulsant profiles of certain new 6-aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones.

    PubMed

    Aboul-Enein, Mohamed N; El-Azzouny, Aida A; Attia, Mohamed I; Maklad, Yousreya A; Aboutabl, Mona E; Ragab, Fatma; Abd El-Hamid, Walaa H A

    2014-09-23

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a-f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a-f which were cyclized under mild conditions to give the spiro compounds 5a-f. Ultimately, compounds 5a-f were alkylated or aralkylated to give the target compounds 6a-i and 6m-u. On the other hand, compounds 6j-l and 6v-x were synthesized from the intermediates 5a-f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a-x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a-x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen.

  13. Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones

    PubMed Central

    Aboul-Enein, Mohamed N.; El-Azzouny, Aida A.; Attia, Mohamed I.; Maklad, Yousreya A.; Aboutabl, Mona E.; Ragab, Fatma; El-Hamid, Walaa H. A. Abd

    2014-01-01

    Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a–l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones (6m–x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino]cycloalkanecarboxamides (3a–f) were prepared via adopting Strecker synthesis on the proper cycloalkanone followed by partial hydrolysis of the obtained nitrile functionality and subsequent N-cyanomethylation. Compounds 3a–f were subjected to complete nitrile hydrolysis to give the respective carboxylic acid derivatives 4a–f which were cyclized under mild conditions to give the spiro compounds 5a–f. Ultimately, compounds 5a–f were alkylated or aralkylated to give the target compounds 6a–i and 6m–u. On the other hand, compounds 6j–l and 6v–x were synthesized from the intermediates 5a–f through alkylation, dehydration and finally tetrazole ring formation. Anticonvulsant screening of the target compounds 6a–x revealed that compound 6g showed an ED50 of 0.0043 mmol/kg in the scPTZ screen, being about 14 and 214 fold more potent than the reference drugs, Phenobarbital (ED50 = 0.06 mmol/kg) and Ethosuximide (ED50 = 0.92 mmol/kg), respectively. Compound 6e exhibited an ED50 of 0.019 mmol/kg, being about 1.8 fold more potent than that of the reference drug, Diphenylhydantoin (ED50 = 0.034 mmol/kg) in the MES screen. Interestingly, all the test compounds 6a–x did not show any minimal motor impairment at the maximum administered dose in the neurotoxicity screen. PMID:25250910

  14. 10 CFR 1.5 - Location of principal offices and regional offices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... offices in the Washington, DC, area are as follows: (1) One White Flint North Building, 11555 Rockville Pike, Rockville, Maryland 20852-2738. (2) Two White Flint North Building, 11545 Rockville...

  15. 10 CFR 1.5 - Location of principal offices and regional offices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... offices in the Washington, DC, area are as follows: (1) One White Flint North Building, 11555 Rockville Pike, Rockville, Maryland 20852-2738. (2) Two White Flint North Building, 11545 Rockville...

  16. 10 CFR 1.5 - Location of principal offices and regional offices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... offices in the Washington, DC, area are as follows: (1) One White Flint North Building, 11555 Rockville Pike, Rockville, Maryland 20852-2738. (2) Two White Flint North Building, 11545 Rockville...

  17. Chemical Characterization of Outdoor and Subway Fine (PM2.51.0) and Coarse (PM10–2.5) Particulate Matter in Seoul (Korea) by Computer-Controlled Scanning Electron Microscopy (CCSEM)

    PubMed Central

    Byeon, Sang-Hoon; Willis, Robert; Peters, Thomas M.

    2015-01-01

    Outdoor and indoor (subway) samples were collected by passive sampling in urban Seoul (Korea) and analyzed with computer-controlled scanning electron microscopy coupled with energy dispersive x-ray spectroscopy (CCSEM-EDX). Soil/road dust particles accounted for 42%–60% (by weight) of fine particulate matter larger than 1 µm (PM2.51.0) in outdoor samples and 18% of PM2.51.0 in subway samples. Iron-containing particles accounted for only 3%–6% in outdoor samples but 69% in subway samples. Qualitatively similar results were found for coarse particulate matter (PM10–2.5) with soil/road dust particles dominating outdoor samples (66%–83%) and iron-containing particles contributing most to subway PM10–2.5 (44%). As expected, soil/road dust particles comprised a greater mass fraction of PM10–2.5 than PM2.51.0. Also as expected, the mass fraction of iron-containing particles was substantially less in PM10–2.5 than in PM2.51.0. Results of this study are consistent with known emission sources in the area and with previous studies, which showed high concentrations of iron-containing particles in the subway compared to outdoor sites. Thus, passive sampling with CCSEM-EDX offers an inexpensive means to assess PM2.51.0 and PM10-2.5 simultaneously and by composition at multiple locations. PMID:25689348

  18. Safety of implantable coronary stents during 1H-magnetic resonance imaging at 1.0 and 1.5 T.

    PubMed

    Strohm, O; Kivelitz, D; Gross, W; Schulz-Menger, J; Liu, X; Hamm, B; Dietz, R; Friedrich, M G

    1999-01-01

    The safety of most available implantable intracoronary stents during magnetic resonance imaging (MRI) has not been sufficiently tested. Minor, but possibly clinically significant, increases in temperature have not been excluded. We measured temperature changes of 14 different stents clinically in use or currently tested for release on the world market. Stents were examined in 1.0- and 1.5-T MR scanners with multiple sequences used in routine cardiac and thoracic MRI examinations ("clinical worst case") and after implantation of the stents into the coronary arteries of excised pig hearts (1.5-T scanner only). We used a highly sensitive infrared camera with a thermal resolution of 10 mK and did not see significant heating of any stent during the examinations. We conclude that MRI is safe in patients with the currently available intracoronary stents.

  19. MABGEL 1: First Phase 1 Trial of the Anti-HIV-1 Monoclonal Antibodies 2F5, 4E10 and 2G12 as a Vaginal Microbicide

    PubMed Central

    Morris, Georgina C.; Wiggins, Rebecca C.; Woodhall, Sarah C.; Bland, J. Martin; Taylor, Carol R.; Jespers, Vicky; Vcelar, Brigitta A.; Lacey, Charles J.

    2014-01-01

    Background Monoclonal antibodies (mAbs) which potently neutralize a broad range of HIV isolates are potential microbicide candidates. To date, topical application of mAbs in humans and their stability in vaginal secretions has not been studied. Objectives To assess the pharmacokinetics and safety of the mAbs 2F5, 4E10 and 2G12 when applied vaginally in women. Design A randomized, double-blind, placebo-controlled phase 1 trial. Methods Twenty-eight healthy, sexually abstinent women administered 2.5 g of gel daily for 12 days containing either 10 or 20 mg/g of each mAb (MABGEL) or placebo. Main clinical evaluations and sampling occurred at baseline, 1, 8, and 24 hours post-1st dose and 12 and 36 hours post-12th dose. Results After adjustment for dilution factors, median levels of 2F5, 4E10 and 2G12 in vaginal secretions at 1 hour post high-dose MABGEL were 7.74, 5.28 and 7.48 mg/ml respectively. Levels of 2F5 and 4E10 declined exponentially thereafter with similar estimated half-lives (4.6 and 4.3 hours). In contrast, 2G12 levels declined more rapidly in the first 8 hours, with an estimated half-life of 1.4 hours during this period. There was no evidence of systemic absorption. There were no significant differences in local or systemic adverse event rates or vaginal flora changes (by qPCR) between active and placebo gel arms. Whilst at least 1 adverse event was recorded in 96% of participants, 95% were mild and none were serious. Conclusions Vaginal application of 50 mg of each mAb daily was safe over a 12 day period. Median mAb concentrations detected at 8 hours post dose were potentially sufficient to block HIV transmission.2G12 exhibited more rapid elimination from the human vagina than 4E10 and 2F5, likely due to poor stability of 2G12 in acidic human vaginal secretions. Further research is needed to develop mAb-based vaginal microbicides and delivery systems. Trial Registration ISRCTN 64808733 UK CRN Portfolio 6470 PMID:25546420

  20. Equine herpesvirus type-1 modulates CCL2, CCL3, CCL5, CXCL9, and CXCL10 chemokine expression.

    PubMed

    Wimer, Christine L; Damiani, Armando; Osterrieder, Nikolaus; Wagner, Bettina

    2011-04-15

    Equine herpesvirus type 1 (EHV-1) is highly prevalent in horses and causes rhinopneumonitis, abortion, and encephalopathy. Studies on the related human herpes simplex virus and of murine models of EHV-1 suggest that chemokines play important roles in coordinating of innate and adaptive immune responses, and thus effective control of herpesvirus infection and prevention of severe clinical disease. Here, equine peripheral blood mononuclear cells (PBMC) were infected with one of three EHV-1 strains, which differ in pathogenicity (RacL11, NY03=abortogenic, Ab4=neurogenic). Changes in CCL2, CCL3, CCL5, CXCL9 and CXCL10 chemokine gene expression relative to non-infected PBMC were measured by real-time PCR. CXCL9 and CXCL10 gene expression was up-regulated 10h post infection and decreased to the level of non-infected cells after 24h. CCL2 and CCL3 were significantly down-regulated 24h post infection with NY03 and Ab4. CCL5 was up-regulated 24h after infection with RacL11. Ab4 infected PBMC had significantly lower expression of all chemokines except CCL2 24h post infection then RacL11 infected cells. While there was not a significant difference between NY03 and the other strains, there was a trend with each chemokine toward NY03 inducing less expression then RacL11 but more then Ab4. The data suggested that EHV-1 infection of PBMC induced up-regulation of inflammatory chemokines CCL5, CXCL9 and CXCL10, and down-regulation of chemotactic CCL2 and CCL3. The data also implies that different EHV-1 strains have varying effects on all five chemokines, with the nuropathogenic strain, Ab4, having the greatest suppressive potential.

  1. GIS Assessment of the PM10, PM2.5 and PM1.0 Concentrations in Urban Area of Tehran in Warm and Cold Seasons

    NASA Astrophysics Data System (ADS)

    Halek, F.; Kavousi-rahim, A.

    2014-10-01

    In recent years, atmospheric models, such as GIS, are used for environmental analysis and the related management for supporting the environmental decision makers in different countries. In this study, concentrations of PM10, PM2.5 and PM1.0 are found in urban areas of Tehran in warm and cold seasons and the data applied in the related modelling, using Arc-GIS. For this purpose, samples were collected from 42 sites in an 18 km2 region located in the west and central parts of Tehran. The mean concentrations of PM1.0, PM2.5 and PM10 are found to be 13.14 μg/m3, 22.67 μg/m3 and 95.72 μg/m3 in the warm season; and 50.12 μg/m3, 70.72 μg/m3 and 193.86 μg/m3 in the cold season respectively. In this paper, with the aid of GIS, concentrations of the suspended particles were measured in 22 major hospitals, the patients in which are in contact with these pollutants. It was found the concentrations of the suspended particles were much higher in the cold season.

  2. 44 CFR 10.5 - Responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Responsibilities. 10.5 Section... SECURITY GENERAL ENVIRONMENTAL CONSIDERATIONS Agency Implementing Procedures § 10.5 Responsibilities. (a... impact statements and assign lead agency responsibility when more than one FEMA office or...

  3. 43 CFR 10.5 - Consultation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Consultation. 10.5 Section 10.5 Public Lands: Interior Office of the Secretary of the Interior NATIVE AMERICAN GRAVES PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony...

  4. 43 CFR 10.5 - Consultation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Consultation. 10.5 Section 10.5 Public Lands: Interior Office of the Secretary of the Interior NATIVE AMERICAN GRAVES PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony...

  5. 43 CFR 10.5 - Consultation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Consultation. 10.5 Section 10.5 Public Lands: Interior Office of the Secretary of the Interior NATIVE AMERICAN GRAVES PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony...

  6. 43 CFR 10.5 - Consultation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Consultation. 10.5 Section 10.5 Public Lands: Interior Office of the Secretary of the Interior NATIVE AMERICAN GRAVES PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony...

  7. 43 CFR 10.5 - Consultation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Consultation. 10.5 Section 10.5 Public Lands: Interior Office of the Secretary of the Interior NATIVE AMERICAN GRAVES PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects, or Objects of Cultural Patrimony...

  8. Safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% eye drops to brinzolamide 1.0%/timolol maleate 0.5% eye drops

    PubMed Central

    Inoue, Kenji; Shiokawa, Minako; Ishida, Kyoko; Tomita, Goji

    2015-01-01

    Purpose To evaluate the safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% fixed-combination (DTFC) eye drops to brinzolamide 1.0%/timolol maleate 0.5% fixed-combination (BTFC) eye drops in patients with primary open-angle glaucoma or ocular hypertension. Methods A total of 35 eyes of 35 patients with primary open-angle glaucoma or ocular hypertension using DTFC eye drops were included. Participants discontinued DTFC drops and immediately began using BTFC drops. All other eye drops currently being used were continued. Intraocular pressure (IOP) 1 and 3 months after switching medications was compared with baseline IOP. One month after switching medications, participant preference and adherence were evaluated. Adverse reactions were monitored at each study visit. Results The IOP was 17.9±2.6 mmHg at baseline and 18.3±4.1 mmHg and 17.8±3.4 mmHg 1 month and 3 months after switching medications, respectively (P=0.633). The frequency of missing a dose was not different before (6.1%) and after (6.1%) switching to BTFC. Significantly fewer participants reported stinging after switching to BTFC (15.2%) than while using DTFC (51.5%, P,0.01). Blurred vision was reported with the same frequency before (39.4%) and after (42.4%) switching to BTFC. A total of 33.3% and 27.3% of patients preferred DTFC and BTFC, respectively. Several patients withdrew from the study because of discomfort (n=2, 5.7%), discharge (n=1, 2.9%), dizziness (n=1, 2.9%), or increased IOP (n=2, 5.7%). Conclusion Switching from DTFC to BTFC was well tolerated and did not result in IOP changes or a decreased patient adherence. When glaucoma patients complain of stinging with DTFC administration, switching to BTFC is an acceptable treatment option. PMID:25914520

  9. Thermally stable compositions including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt

    DOEpatents

    Hiskey, Michael A.; Huynh, My Hang

    2010-01-26

    An explosive formulation including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt and a high temperature binder is disclosed together with a process of preparing 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt.

  10. Apparatus to measure the vapor pressure of slowly decomposing compounds from 1 Pa to 10(5) Pa.

    PubMed

    Berg, Robert F

    2015-11-01

    This article describes an apparatus and method for measuring vapor pressures in the range from 1 Pa to 10(5) Pa. Its three distinctive elements are : (1) the static pressure measurements were made with only a small temperature difference between the vapor and the condensed phase, (2) the sample was degassed in situ, and (3) the temperature range extended up to 200 °C. The apparatus was designed to measure metal-organic precursors, which often are toxic, pyrophoric, or unstable. Vapor pressures are presented for naphthalene, ferrocene, diethyl phthalate, and TEMAH (tetrakisethylmethylaminohafnium). Also presented are data for the temperature-dependent decomposition rate of TEMAH.

  11. Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10.

    PubMed

    Klein, Fabrice A C; Zeder-Lutz, Gabrielle; Cousido-Siah, Alexandra; Mitschler, André; Katz, Aline; Eberling, Pascal; Mandel, Jean-Louis; Podjarny, Alberto; Trottier, Yvon

    2013-10-15

    A long-standing pathomechanistic model proposes that the polyglutamine (polyQ)-length-dependent toxicity threshold observed in all polyQ diseases is triggered by a conformational change within the monomer that occurs only above a certain polyQ length. If true, this yet undefined and elusive mutant-specific toxic conformation would constitute a direct therapeutic target. Three anti-polyQ antibodies-MW1, 1C2 and 3B5H10-have been extensively used to probe the conformation of polyQ. The crystal structure of the MW1 epitope reveals a linear, non-pathogenic polyQ. In contrast, although the detailed structure of its epitope is unknown, the 3B5H10 antibody is widely advertised and used as a conformational antibody that recognizes the toxic conformation of expanded polyQ. We solved the crystal structure of the 1C2 antigen-binding domain (1C2-Fab) and performed a direct comparison between the 1C2, MW1 and 3B5H10 structures. The MW1 and 1C2 antibodies have similar sequences and structures, consistent with their binding to short polyQ and their polyQ length-discrimination properties. Unexpectedly, the 3B5H10 antibody also shares striking features with MW1 and 1C2, which prompted us to revisit its binding properties. We show that the 3B5H10 epitope is actually a short, non-pathogenic polyQ. All three antibodies MW1, 1C2 and 3B5H10 interact similarly with polyQ of various lengths, and bind small polyQ epitopes in similar linear and extended conformations. Together with studies published during the recent years, our work argues against the hypothesis that a mutant-specific conformation in monomeric polyQ molecules is the toxic entity responsible for polyQ diseases.

  12. Audiograms estimated from brainstem tone-evoked potentials in dogs from 10 days to 1.5 months of age.

    PubMed

    Poncelet, Luc C; Coppens, Angélique G; Deltenre, Paul F

    2002-01-01

    The objective of this study was to build audiograms from thresholds of brainstem tone-evoked potentials in dogs and to evaluate age-related change of the audiogram in puppies. Results were obtained from 9 Beagle puppies 10-47 days of age. Vertex to mastoid brainstem auditory-evoked potentials in response to 5.1-millisecond Hanning-gated sine waves with frequencies octave-spaced from 0.5 to 32 kHz were recorded. Three dogs were examined at 10, 13, 19, 25, and 45 days. Four other dogs were examined at 16 days. Data from 7 dogs between 42 and 47 days of age were pooled to obtain audiogram reference values in 1.5-month-old puppies. The best auditory threshold lowered from above 60 dB sound pressure level (SPL) to values close to 0 dB SPL between 13 and 25 days of age and then stabilized. The audible frequency range widened, including 32 kHz in all tested dogs from the 19th day. In the 7 1.5-month-old puppies, the mean auditory threshold decreased by 11 dB per octave from 0.5 to 2 kHz. The auditory threshold was lowest and held the same value from 2 to 8 kHz. The mean auditory threshold increased by 20 dB per octave from 8 to 32 kHz. Near threshold, click-evoked potentials test only a small part of the audible frequency range in dogs. Use of tone-evoked potentials may become a powerful tool in investigating dogs with possible partial hearing loss, including during the auditory system maturation period.

  13. Structural and magnetic characterization of BiFe{sub x}Mn{sub 2-x}O{sub 5} oxides (x=0.5, 1.0)

    SciTech Connect

    Retuerto, M.; Martinez-Lope, M.J.; Krezhov, K.; Fernandez-Diaz, M.T.; Alonso, J.A.

    2011-09-15

    The title compounds have been synthesized by a citrate technique followed by thermal treatments in air (BiFe{sub 0.5}Mn{sub 1.5}O{sub 5}) or under high oxygen pressure conditions (BiFeMnO{sub 5}), and characterized by X-ray diffraction (XRD), neutron powder diffraction (NPD) and magnetization measurements. The crystal structures have been refined from NPD data in the space group Pbam at 295 K. These phases are isostructural with RMn{sub 2}O{sub 5} oxides (R=rare earths) and contain infinite chains of Mn{sup 4+}O{sub 6} octahedra sharing edges, linked together by (Fe,Mn){sup 3+}O{sub 5} pyramids and BiO{sub 8} units. These units are strongly distorted with respect to those observed in other RFeMnO{sub 5} compounds, due to the presence of the electronic lone pair on Bi{sup 3+}. It is noteworthy the certain level of antisite disorder exhibited in both samples, where the octahedral positions are partially occupied by Fe cations, and vice versa. BiFe{sub x}Mn{sub 2-x}O{sub 5} (x=0.5, 1.0) are short-range magnetically ordered below 20 K for x=0.5 and at 40 K for x=1.0. The main magnetic interactions seem to be antiferromagnetic (AFM); however, the presence of a small hysteresis in the magnetization cycles indicates the presence of some weak ferromagnetic (FM) interactions. - Graphical Abstract: BiFe{sub x}Mn{sub 2-x}O{sub 5} (x=0.5, 1.0) samples are isostructural with BiMn{sub 2}O{sub 5}, belonging to the Pbam space group. The crystal structure contains infinite chains of edge-sharing Mn{sup 4+}O{sub 6} octahedra, interconnected by dimer units of Fe{sup 3+}O{sub 5} square pyramids. These units are strongly distorted due to the presence of the electronic lone pair on Bi{sup 3+}. They are magnetically ordered at low temperatures. The main magnetic interactions seem to be antiferromagnetic with the presence of some weak ferromagnetic response. Highlights: > Two new compounds of formula BiFe{sub x}Mn{sub 2-x}O{sub 5} (x=0.5, 1.0) have been obtained. > Their crystallographic

  14. Volumetric Properties of the Mixture 1,5-Dibromopentane C5H10Br2 + C7H16 Heptane (VMSD1511, LB5019_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,5-Dibromopentane C5H10Br2 + C7H16 Heptane (VMSD1511, LB5019_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  15. Crystal structure of ethyl 2-[9-(5-bromo-2-hy-droxy-phen-yl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-deca-hydro-acridin-10-yl]acetate.

    PubMed

    Mohamed, Shaaban K; Akkurt, Mehmet; Jasinski, Jerry P; Abdelhamid, Antar A; Tamam, Asmaa H; Albayati, Mustafa R

    2015-12-01

    In the title compound, C23H24BrNO5, the central 1,4-di-hydro-pyridine ring of the 1,2,3,4,5,6,7,8,9,10-deca-hydro-acridine ring system adopts a half-chair conformation. The two cyclo-hexene rings fused to the central ring both have a twisted-boat conformation. The mean planes of the bromo-hydroxy-phenyl ring and the major and minor components of the disordered ethyl amino-acetate moiety make dihedral angles of 78.99 (12), 85.9 (2) and 88.3 (9)°, respectively, with the 1,4-di-hydro-pyridine ring. The terminal ethyl group of the ethyl amino-acetate moiety is disordered over two sets of sites with refined occupancies of 0.768 (17) and 0.232 (17). The mol-ecular conformation is stabilized by an intra-molecular O-H⋯O hydrogen bond, forming an S(8) ring motif. In the crystal, C-H⋯O hydrogen bonds connect the mol-ecules into layers parallel to (001), enclosing R 1 (2)(7) ring motifs.

  16. Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.

    PubMed

    Lingam, V S Prasadarao; Dahale, Dnyaneshwar H; Rathi, Vijay E; Shingote, Yogesh B; Thakur, Rajni R; Mindhe, Ajit S; Kummari, Srinivas; Khairatkar-Joshi, Neelima; Bajpai, Malini; Shah, Daisy M; Sapalya, Ratika S; Gullapalli, Srinivas; Gupta, Praveen K; Gudi, Girish S; Jadhav, Satyawan B; Pattem, Rambabu; Thomas, Abraham

    2015-10-22

    We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactive diarylpyridine-2-amine derivative 3b by extensive and systematic analogue synthesis and SAR analysis. Further optimization of the scaffold resulted in identification of pyridin-2(1H)-one 18b as a lead compound with good potency (IC50 = 1.6 nM) and selectivity (>6000-fold) over other related PDEs but with a poor pharmacokinetic profile. Careful metabolite profiling of 18b revealed that poor systemic exposure in rats (Cmax = 44 ng/mL; AUC0-t = 359 ng · h/mL) at 10 mg/kg was due to the formation of O-glucuronide conjugate by phase 2 metabolism. The structure of the glucuronide metabolite was confirmed by retention time and LC-MS/MS fragmentation matching with the synthetic glucuronide 26. The problem of low exposure of 18b was effectively addressed by its conversion to an acetate prodrug 25b, which upon oral dosing resulted in an improved pharmacokinetic profile (Cmax = 359 ng.h/mL; AUC0-t = 2436 ng.h/mL) and a desirable brain to plasma ratio of 1.2. The prodrug 25b showed good efficacy in selected rodent models of psychosis.

  17. Characterization of the Ti-10Nb-10Zr-5Ta Alloy for Biomedical Applications. Part 1: Microstructure, Mechanical Properties, and Corrosion Resistance

    NASA Astrophysics Data System (ADS)

    Vladescu, A.; Braic, V.; Balaceanu, M.; Braic, M.; Parau, A. C.; Ivanescu, S.; Fanara, C.

    2013-08-01

    Ti-10Nb-10Zr-5Ta alloy was investigated as possible material candidate for replacing Ti6Al4V in medical applications. The alloy was prepared in a levitation melting furnace and characterized in terms of elemental and phase composition, microstructure, mechanical properties, and corrosion resistance in simulated body fluid and Fusayama Meyer artificial saliva solutions. The characteristics of the new alloy were compared to those of the Ti6Al4V alloy. The Ti-10Nb-10Zr-5Ta system was found to posses of a polyhedral structure consisting in α' and β phases. X-ray structural analysis revealed a mixture of hexagonal α' martensite (main phase, with grain size of about 21 nm) and β bcc phase. The Ti-10Nb-10Zr-5Ta alloy exhibited some better mechanical properties (Young modulus, tensile properties) and corrosion resistance (polarization resistance, corrosion current density, and corrosion rate), as compared to Ti6Al4V alloy.

  18. Syllabic (~2-5 Hz) and fluctuation (~1-10 Hz) ranges in speech and auditory processing

    PubMed Central

    Edwards, Erik; Chang, Edward F.

    2013-01-01

    Given recent interest in syllabic rates (~2-5 Hz) for speech processing, we review the perception of “fluctuation” range (~1-10 Hz) modulations during listening to speech and technical auditory stimuli (AM and FM tones and noises, and ripple sounds). We find evidence that the temporal modulation transfer function (TMTF) of human auditory perception is not simply low-pass in nature, but rather exhibits a peak in sensitivity in the syllabic range (~2-5 Hz). We also address human and animal neurophysiological evidence, and argue that this bandpass tuning arises at the thalamocortical level and is more associated with non-primary regions than primary regions of cortex. The bandpass rather than low-pass TMTF has implications for modeling auditory central physiology and speech processing: this implicates temporal contrast rather than simple temporal integration, with contrast enhancement for dynamic stimuli in the fluctuation range. PMID:24035819

  19. Creep Properties of Sn-1.0Ag-0.5Cu Lead-Free Solder with Ni Addition

    NASA Astrophysics Data System (ADS)

    Che, F. X.; Zhu, W. H.; Poh, Edith S. W.; Zhang, X. R.; Zhang, Xiaowu; Chai, T. C.; Gao, S.

    2011-03-01

    In this work, tensile creep tests for Sn-1.0Ag-0.5Cu-0.02Ni solder have been conducted at various temperatures and stress levels to determine its creep properties. The effects of stress level and temperature on creep strain rate were investigated. Creep constitutive models (such as the simple power-law model, hyperbolic sine model, double power-law model, and exponential model) have been reviewed, and the material constants of each model have been determined based on experimental results. The stress exponent and creep activation energy have been studied and compared with other researchers' results. These four creep constitutive models established in this paper were then implemented into a user-defined subroutine in the ANSYS™ finite-element analysis software to investigate the creep behavior of Sn-1.0Ag-0.5Cu-0.02Ni solder joints of thin fine-pitch ball grid array (TFBGA) packages for the purpose of model comparison and application. Similar simulation results of creep strain and creep strain energy density were achieved when using the different creep constitutive models, indicating that the creep models are consistent and accurate.

  20. Fluorescence excitation and emission spectra of 1,5-dihydroxyanthraquinone-d2 in n-hexane at 10 K

    NASA Astrophysics Data System (ADS)

    Smulevich, Giulietta; Foggi, Paolo

    1987-11-01

    The fluorescence excitation, between 430 and 505 nm, and emission, between 505 and 725 nm, spectra in n-hexane of 1,5-dihydroxyanthraquinone-d0 and -d2 at 10 K have been measured. Dual excitation and emission associated to excited state proton transfer were observed. Apart from the long wavelength emission, well resolved vibrational structures were obtained. A remarkable spectral shift (684 cm-1) of the origin of the high frequency transition was observed upon deuteration. The energy gaps between the transition origins both in excitation and emission as well as the isotopic shifts of the origins, were interpreted in terms of Lippincott-Schroeder asymmetric double minimum potential functions along the OH coordinate. An extra fluorescence occurs in the low frequency range, vanishing upon deuteration. It was explained as due to the ν(OH) stretching mode of the high frequency emission enhanced via vibronic coupling between the two ground states.

  1. Extrasolar Giant Magnetospheric Response to Steady-state Stellar Wind Pressure at 10, 5, 1, and 0.2 au

    NASA Astrophysics Data System (ADS)

    Tilley, Matt A.; Harnett, Erika M.; Winglee, Robert M.

    2016-08-01

    A three-dimensional, multifluid simulation of a giant planet’s magnetospheric interaction with steady-state stellar wind from a Sun-like star was performed for four different orbital semimajor axes—10, 5, 1, and 0.2 au. We simulate the effect of the increasing, steady-state stellar wind pressure related to the planetary orbital semimajor axis on the global magnetospheric dynamics for a Saturn-like planet, including an Enceladus-like plasma torus. Mass-loss processes are shown to vary with orbital distance, with the centrifugal interchange instability displayed only in the 10 and 5 au cases, which reach a state of mass-loss equilibrium more slowly than the 1 or 0.2 au cases. The compression of the magnetosphere in the 1 and 0.2 au cases contributes to the quenching of the interchange process by increasing the ratio of total plasma thermal energy to corotational energy. The strength of field-aligned currents, associated with auroral radio emissions, is shown to increase in magnitude and latitudinal coverage with a corresponding shift equatorward from increased dynamic ram pressure experienced in the hotter orbits. Similar to observed hot Jovian planets, the warm exo-Saturn simulated in the current work shows enhanced ion density in the magnetosheath and magnetopause regions, as well as the plasma torus, which could contribute to altered transit signals, suggesting that for planets in warmer (>0.1 au) orbits, planetary magnetic field strengths and possibly exomoons—via the plasma torus—could be observable with future missions.

  2. Extrasolar giant magnetospheric response to steady-state stellar wind pressure at 10, 5, 1, and 0.2 AU

    NASA Astrophysics Data System (ADS)

    Tilley, Matt; Harnett, Erika; Winglee, Robert

    2016-10-01

    A three-dimensional, multifluid simulation of a giant planet's magnetospheric interaction with steady-state stellar wind from a Sun-like star was performed for four different orbital semi-major axes - 10, 5, 1 and 0.2 AU. We simulate the effect of the increasing, steady-state stellar wind pressure related to the planetary orbital semi-major axis on the global magnetospheric dynamics for a Saturn-like planet, including an Enceladus-like plasma torus. Mass loss processes are shown to vary with orbital distance, with the centrifugal interchange instability displayed only in the 10 AU and 5 AU cases which reach a state of mass loss equilibrium more slowly than the 1 AU or 0.2 AU cases. The compression of the magnetosphere in the 1 AU and 0.2 AU cases contributes to the quenching of the interchange process by increasing the ratio of total plasma thermal energy to corotational energy. The strength of field-aligned currents (FAC), associated with auroral radio emissions, are shown to increase in magnitude and latitudinal coverage with a corresponding shift equatorward from increased dynamic ram pressure experienced in the hotter orbits. Similar to observed hot Jovian planets, the warm exo-Saturn simulated in the current work shows enhanced ion density in the magnetosheath and magnetopause regions, as well as the plasma torus which could contribute to altered transit signals, suggesting that for planets in warmer (> 0.1 AU) orbits, planetary magnetic field strengths and possibly exomoons - via the plasma torus - could be observable with future missions.

  3. 2-Sulfanylidene-1,3-dithiolo[4,5-b]naphtho­[2,3-e][1,4]dithiine-5,10-dione

    PubMed Central

    Méndez-Rojas, Miguel Angel; Bernès, Sylvain; Pérez-Benítez, Aarón; Romero Zarazúa, María Fernanda; Castellanos-Uribe, Adrián

    2011-01-01

    The title mol­ecule, C13H4O2S5, is folded by 47.83 (6)° along the S⋯S vector of the [1,4]dithiine six-membered ring, with the naphtho­quinone and [1,3]dithiole-2-thione moieties being nearly planar [largest deviations from least-squares planes = 0.028 (2) and 0.016 (1) Å, respectively]. This boat conformation is close to that observed in the analogous compound [Mendez-Rojas et al. (2001). J. Chem. Crystallogr. 31, 17–28] including a 2-oxo group [folding angle: 42.3 (1)° at 213 (2) K]. Both compounds are indeed isomorphous, and the small difference in the folding angle probably results from the involvement of the thioxo group of the title compound in inter­molecular S⋯S contacts [3.5761 (13) Å]. In the crystal structure, mol­ecules are stacked in the [100] direction, with dithiole rings making π–π inter­actions. In a stack, alternating short and long separations are observed between the centroids of dithiole rings, 3.5254 (17) and 4.7010 (18) Å. PMID:22219881

  4. Crystal structure of a binuclear nickel(II) complex constructed of 1H-imidazo[4,5-f][1,10]phenanthroline and doubly deprotonated benzene-1,3,5-tri­carb­oxy­lic acid

    PubMed Central

    Lv, Ying; Hao, Xiang-Rong

    2015-01-01

    The title complex, [Ni2(C9H4O6)2(C13H8N4)2(H2O)4]·2H2O, bis­(μ-5-carb­oxy­benzene-1,3-di­carboxyl­ato-κ2 O 1:O 1′)bis­[di­aqua(1H-imidazo[4,5-f][1,10]phenanthroline-κ2 N 7,N 8)nickel(II)] di­hydrate, was obtained under solvothermal conditions by the reaction of benzene-1,3,5-tricarboxylic acid (H3BTC) with Ni(NO3)2 in the presence of 1H-imidazo[4,5-f][1,10]phenanthroline (IP). The crystal has triclinic (P-1) symmetry with a centrosymmetric binuclear nickel(II) cluster. The NiII atom is coordinated by two N atoms from a chelating 1H-imidazo[4,5-f][1,10]phenanthroline ligand, two carboxyl­ate O atoms from two 5-carb­oxy­benzene-1,3-di­carboxyl­ate ligands and two water mol­ecules in a slightly distorted octa­hedral geometry. Two carboxyl­ate groups bridge two NiII cations, forming the binuclear complex. Extensive N—H⋯O, O—H⋯O and O—H⋯N hydrogen bonding is present in the crystal structure, forming a three-dimensional supermolecular framework. Weak π–π stacking is observed between parallel HBTC2− and IP ring systems, the face-to-face separation being 3.695 (2) Å. PMID:26029419

  5. In vivo and in vitro estrogenic profile of 17β-amino-1,3,5(10)estratrien-3-ol.

    PubMed

    Lemini, Cristina; Jaimez, Ruth; Pozas, Rocio; Franco, Yanira; Avila, María Estela; Figueroa, Alejandra; Medina, Martha; Lemus, Ana Elena; García-Becerra, Rocío; Ordaz-Rosado, David; Larrea, Fernando

    2015-03-01

    17β-amino-1,3,5(10)estratrien-3-ol (17βAE2), is the 17β-aminoestrogens prototype possessing anticoagulant activity, contrasting with the procoagulant effects of 17β-estradiol (17βE2). Its estrogenicity profile has not been reported, and it was evaluated by uterotrophic assay, estrogen receptor binding affinity and its ability to induce gene transcription of the human estrogen receptor (hER)α mediated in a Saccharomyces cerevisiae yeast expression system. Additionally, 17βAE2 and 17αAE2 were compared with 17βE2 in HeLa cells co-transfected with expression vectors for hERα or hERβ subtypes and for an estrogen-responsive reporter gene. Immature female CD1 mice and Wistar rats (21 days old) were treated for three days with 17βAE2 (10-5000 μg/kg), 17βE2 (0.001-1000 μg/kg) or vehicle (propylenglycol 10 ml/kg) and uterine weights were estimated. 17βAE2 increased uterine weight in a dose-dependent manner. The effective dose (ED)50 uterine weight values: 17βAE2=552 and 764 μg/kg (17βE2=4.8 and 16 μg/kg) and their relative uterotrophic potency were 0.86 and 2.1 (17βE2=100) in mice and rats, respectively. 17βAE2 competed with [(3)H]E2 for the estrogen receptor. The 17βAE2 relative binding affinities (RBAs) were: 0.074; Ki=2.2×10(-6)M (17βE2=100; Ki=1.6×10(-9)M); 0.029 and Ki=3.8×10(-6)M (17βE2=100; Ki=1.1×10(-9)M) for mice and rats uteri respectively. 17βAE2 activated hERα-mediated β-galactosidase transcription activity in the yeast system co-transfected with hERα gene. 17βAE2 effective concentration (EC)50=1.82 μM (17βE2=2.14 nM) with a relative potency of 0.12 (17βE2=100). These transactivation effects were abolished by the antagonist fulvestrant (ICI 182,780), similarly to 17βE2. 17βAE2 and 17αAE2 bind with low relative affinity to hERα and hERβ. Both induced hER-mediated reporter gene transactivation in a dose-response manner. The overall results provide evidence that 17βAE2 has a weak agonist estrogenic action greatly mediated

  6. 10 CFR 5.105 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Definitions. 5.105 Section 5.105 Energy NUCLEAR REGULATORY... regulations means the provisions set forth at §§ 5.100 through 5.605. Transition plan means a plan subject to... transition from being an educational institution that admits only students of one sex to being one...

  7. 21 CFR 73.3120 - 16,17-Dimethoxydinaphtho [1,2,3-cd:3′,2′,1′-lm] perylene-5,10-dione.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false 16,17-Dimethoxydinaphtho perylene-5,10-dione. 73.3120 Section 73.3120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... to exceed the minimum reasonably required to accomplish the intended coloring effect....

  8. 21 CFR 73.3120 - 16,17-Dimethoxydinaphtho [1,2,3-cd:3′,2′,1′-lm] perylene-5,10-dione.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false 16,17-Dimethoxydinaphtho perylene-5,10-dione. 73.3120 Section 73.3120 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... to exceed the minimum reasonably required to accomplish the intended coloring effect....

  9. Synthesis and photoluminescence control of Ca10.5-1.5xLax(PO4)7:Eu2+ phosphors by aliovalent cation substitution

    NASA Astrophysics Data System (ADS)

    Fan, Yanting; Tang, Miao; Qiu, Zhongxian; Zhang, Jilin; Yu, Liping; Li, Chengzhi; Lian, Shixun; Zhou, Wenli

    2017-02-01

    A range of Ca10.5-1.5xLax(PO4)7:Eu2+phosphors were synthesized by high temperature solid state method. Subsequently we studied the crystal structures and luminescent properties through X-ray diffraction, photoluminescence and photoluminescence excitation, diffuse reflection spectra, Raman spectra and decay curves systematically. Based on the special crystal structure ofβ-Ca3(PO4)2:Eu2+, its emission undergoes a variation from violet-blue to cyan through introducing La3+. The substitution of La3+ for Ca2+ could form some cation vacancies in Ca(4) sites according to the scheme 3Ca2+= 2La3++ □ due to the different ion valence, which compels Eu2+ to migrate from Ca(4) site to other sites. Additionally, the formation of the cation vacancies can further reduce the thermal stability of phosphors.

  10. 44 CFR 10.5 - Responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Responsibilities. 10.5... Responsibilities. (a) The Regional Administrators shall, for each action not categorically excluded from this... impact statements and assign lead agency responsibility when more than one FEMA office or...

  11. Study of the reaction npπ → npπ+π- at 1.0 and 1.5 GeV

    NASA Astrophysics Data System (ADS)

    Jerusalimov, A. P.; Belyaev, A. V.; Ladygin, V. P.; Kurilkin, A. K.; Troyan, A. Yu.; Troyan, Yu. A.

    2015-07-01

    The np → npπ + π - reaction has been studied at the incident neutron energies of 1.0 GeV and 1.5 GeV in 4 π-geometry using the neutron beam produced by the breakup of the relativistic deuterons at the JINR Synchrophasotron. The np → npπ + π - data obtained at 1.5 GeV demonstrate the dominance of the ΔΔ excitation process with a significant contribution of the higher-lying baryonic resonances, while the data at 1.0 GeV show a non-resonant behavior. The angular and mass distributions are compared with the predictions of different models suggested for the double pion production in the NN collisions. The calculations performed within the model based on the reggeized π-exchange taking one baryon exchange into account are in good agreement with the experimental data obtained at both energies.

  12. Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.

    PubMed

    Nabid, Mohammad Reza; Rezaei, Seyed Jamal Tabatabaei; Ghahremanzadeh, Ramin; Bazgir, Ayoob

    2010-01-01

    Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.

  13. Synthesis of a novel 5a,10a-dihydroxy-5aH-[1,3]dioxolo[4,5-f] indeno[1,2-b]benzofuran-10(10aH)-one their XRD, FTIR, NMR and DFT studies

    NASA Astrophysics Data System (ADS)

    Aggarwal, Komal; Khurana, Jitender M.

    2017-02-01

    A novel compound 5a,10a-dihydroxy-5aH-[1,3]dioxolo[4,5-f]indeno[1,2-b]benzofuran-10 (10aH)-one (1) was synthesized and its structure has been characterized by X-ray crystallography, FTIR and NMR studies. X-ray studies revealed the presence of π-π stacking and intermolecular hydrogen bonding interactions which stabilises the molecular lattice. A detailed interpretation of vibrational spectra has been carried out on the basis of peak positions and relative intensities. The optimized molecular geometry, vibrational frequencies and NMR analysis of the compound in the ground state have also been calculated by the density function theory method (DFT) with 6-311G (d,p) basis set. All the theoretically obtained data has been compared with experimental data and it shows good agreement. TDDFT calculations were used to compare the experimental and theoretical absorption spectra. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. In addition, the molecular electrostatic potential (MEP) analysis of the title molecule has been investigated using theoretical calculations.

  14. New 5-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-ones with antiarrhythmic activity.

    PubMed

    Poppe, H; Kaverina, N V; Lyskovzev, V V; Egerland, U; Sauer, W; Lichoscherstow, A; Rüger, C; Skoldinow, A

    1997-11-01

    A series of new 5-substituted tricyclic 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-ones was identified as potential antiarrhythmic agents against bradyarrhythmias [1, 2]. The in vitro and in vivo interactions of the compounds with muscarinic receptors and the antiarrhythmic activity were examined. In receptor binding studies some derivatives showed a high affinity to the cardiac M2 receptor (Ki 10 nmol/l), an equal or smaller affinity to cortical M1 receptor and a lower affinity to the glandular M3 binding site. Functional experiments showed the derivatives as competitive antagonists with high affinity to the cardiac and smaller affinity to the intestinal muscarinic receptor. In vivo experiments correspond with the M2 selectivity. First the vagal or agonist-induced bradycardia was inhibited in rats and guinea pigs while the McNA-343 induced increase of blood pressure, methacholine-induced bronchi and bladder constriction as well as the salivation were inhibited only at higher doses. In conscious cats the tachycardia was examined in comparison with pupillomotoricity. The effect duration and the therapeutical range were determined in comparison to the M2 selective blocking agent AF-DX116. The antiarrhythmic activity was examined compared to quinidine sulfate in CaCl2-arrhythmia of rats, in atrial fibrillation and atrial flutter in dogs according to Scherf [2] and in electric induced atrial fibrillation under vagal stimulation in cats. In the atrial arrhythmias the derivatives are clearly longer effective than quinidine sulfate. The antiischemic activity was examined in the two-stages coronary ligature in dogs according to Harris. The long-running regularization of ectopies (about 2 h after i.v. injection) occurred without decrease of the heart rate, an effect particularly convenient to therapy of bradycardic dysrhythmias.

  15. 10 CFR 36.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Interpretations. 36.5 Section 36.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS General Provisions § 36.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  16. 10 CFR 39.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Interpretations. 39.5 Section 39.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING General Provisions § 39.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  17. 10 CFR 36.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Interpretations. 36.5 Section 36.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS General Provisions § 36.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  18. 10 CFR 39.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 39.5 Section 39.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING General Provisions § 39.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  19. 10 CFR 39.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Interpretations. 39.5 Section 39.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING General Provisions § 39.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  20. 10 CFR 36.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 36.5 Section 36.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS General Provisions § 36.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  1. 10 CFR 39.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Interpretations. 39.5 Section 39.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING General Provisions § 39.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  2. 10 CFR 36.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Interpretations. 36.5 Section 36.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS General Provisions § 36.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  3. 10 CFR 39.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Interpretations. 39.5 Section 39.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING General Provisions § 39.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  4. 10 CFR 36.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Interpretations. 36.5 Section 36.5 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS General Provisions § 36.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the...

  5. 10 CFR 5.515 - Compensation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Compensation. 5.515 Section 5.515 Energy NUCLEAR... Activities Prohibited § 5.515 Compensation. A recipient shall not make or enforce any policy or practice that, on the basis of sex: (a) Makes distinctions in rates of pay or other compensation; (b) Results in...

  6. 10 CFR 5.515 - Compensation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Compensation. 5.515 Section 5.515 Energy NUCLEAR... Activities Prohibited § 5.515 Compensation. A recipient shall not make or enforce any policy or practice that, on the basis of sex: (a) Makes distinctions in rates of pay or other compensation; (b) Results in...

  7. 10 CFR 5.515 - Compensation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Compensation. 5.515 Section 5.515 Energy NUCLEAR... Activities Prohibited § 5.515 Compensation. A recipient shall not make or enforce any policy or practice that, on the basis of sex: (a) Makes distinctions in rates of pay or other compensation; (b) Results in...

  8. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  9. 10 CFR 5.540 - Advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Advertising. 5.540 Section 5.540 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Prohibited § 5.540 Advertising. A recipient shall not in any advertising related to employment...

  10. 10 CFR 5.540 - Advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Advertising. 5.540 Section 5.540 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Prohibited § 5.540 Advertising. A recipient shall not in any advertising related to employment...

  11. 10 CFR 5.540 - Advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Advertising. 5.540 Section 5.540 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Prohibited § 5.540 Advertising. A recipient shall not in any advertising related to employment...

  12. 10 CFR 5.540 - Advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Advertising. 5.540 Section 5.540 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Prohibited § 5.540 Advertising. A recipient shall not in any advertising related to employment...

  13. 10 CFR 5.540 - Advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Advertising. 5.540 Section 5.540 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL... Prohibited § 5.540 Advertising. A recipient shall not in any advertising related to employment...

  14. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  15. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  16. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  17. 10 CFR 9.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Interpretations. 9.5 Section 9.5 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.5 Interpretations. Except as specifically authorized by the Commission in writing, no interpretation of the meaning of the regulations in this part by an officer or employee of...

  18. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  19. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  20. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  1. 10 CFR 5.230 - Transition plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Transition plans. 5.230 Section 5.230 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Coverage § 5.230 Transition plans. (a) Submission of plans. An institution to... either a single transition plan applicable to all such units, or a separate transition plan applicable...

  2. 10 CFR 5.430 - Financial assistance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Financial assistance. 5.430 Section 5.430 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 5.430 Financial assistance. (a) General. Except as provided in paragraphs (b) and (c) of...

  3. 10 CFR 5.430 - Financial assistance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Financial assistance. 5.430 Section 5.430 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 5.430 Financial assistance. (a) General. Except as provided in paragraphs (b) and (c) of...

  4. 10 CFR 5.430 - Financial assistance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Financial assistance. 5.430 Section 5.430 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 5.430 Financial assistance. (a) General. Except as provided in paragraphs (b) and (c) of...

  5. 10 CFR 5.430 - Financial assistance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Financial assistance. 5.430 Section 5.430 Energy NUCLEAR... FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 5.430 Financial assistance. (a) General. Except as provided in paragraphs (b) and (c) of...

  6. Bilateral perisylvian polymicrogyria, periventricular nodular heterotopia, and left ventricular noncompaction in a girl with 10.5-11.1 Mb terminal deletion of 1p36.

    PubMed

    Saito, Shoji; Kawamura, Rie; Kosho, Tomoki; Shimizu, Takashi; Aoyama, Koki; Koike, Kenichi; Wada, Takahito; Matsumoto, Naomichi; Kato, Mitsuhiro; Wakui, Keiko; Fukushima, Yoshimitsu

    2008-11-15

    Monosomy 1p36 is a common subtelomeric microdeletion syndrome, characterized by craniofacial dysmorphisms, developmental delay, mental retardation, hypotonia, epilepsy, cardiovascular complications, and hearing impairment; deleted regions have been mapped within 10.0 Mb from the telomere in most documented cases. We report on a girl with a 10.5-11.1 Mb terminal deletion of 1p36 shown by fluorescence in situ hybridization (FISH). She had three distinct structural abnormalities: bilateral perisylvian polymicrogyria, periventricular nodular heterotopia, and left ventricular noncompaction. She died in early infancy with intractable epilepsy, progressive congestive heart failure and pulmonary hypertension. To date, this is the first case with monosomy 1p36, complicated by this combination of manifestations; she is also the first who had possibly a simple terminal deletion of 1p36 and died in early infancy. An atypically large deletion in this patient might be the basis for the development of these features and the severe clinical course.

  7. 10 CFR 50.5 - Deliberate misconduct.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Deliberate misconduct. 50.5 Section 50.5 Energy NUCLEAR... Deliberate misconduct. (a) Any licensee, applicant for a license, employee of a licensee or applicant; or any... licensee's or applicant's activities in this part, may not: (1) Engage in deliberate misconduct that...

  8. 10 CFR 5.115 - Assurance required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Assurance required. 5.115 Section 5.115 Energy NUCLEAR.... (1) In the case of Federal financial assistance extended to provide real property or structures... transferee, for the period during which the real property or structures are used to provide an...

  9. 10 CFR 5.115 - Assurance required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Assurance required. 5.115 Section 5.115 Energy NUCLEAR.... (1) In the case of Federal financial assistance extended to provide real property or structures... transferee, for the period during which the real property or structures are used to provide an...

  10. Intergranular pinning potential and critical current in the magnetic superconductor Ru Sr2 Gd1.5 Ce0.5 Cu2 O10

    NASA Astrophysics Data System (ADS)

    Das Virgens, M. G.; García, S.; Continentino, M. A.; Ghivelder, L.

    2005-02-01

    The intergranular pinning potential U and the critical current density JC for polycrystalline RuSr2Gd1.5Ce0.5Cu2O10 ruthenate-cuprate were determined at zero magnetic field and temperature through the frequency shift in the peak of the imaginary part of the ac magnetic susceptibility, χ″ . A critical state model, including a flux creep term, was found to accurately describe the χ″ behavior. The obtained values, U(H=0,T=0)≅30meV and JC(H=0,T=0)≅110A/cm2 are about two orders of magnitude and four times lower, respectively, in comparison with the high- TC cuprate YBa2Cu3O7 . These results were ascribed to the effects of the Ru magnetization on the connectivity of the weak-linked network, giving an intrinsic local field at the junctions of ˜15Oe . The impact on JC is less intense because of the small average grain radius (˜1μm) . The intragranular London penetration length at T=0[λL(0)≅2μm] was derived using a Kim-type expression for the field dependence of JC . A possible source for the large value of λL in comparison to the high- Tc cuprates is suggested to come from a strong intragrain granularity, due to structural domains of coherent-rotated RuO6 octahedra separated by antiphase boundaries.

  11. Vibrational spectroscopy investigation using ab initio and density functional theory analysis on the structure of 5-chloro-10-oxa-3-thia-tricyclo[5.2.1.0 1,5]dec-8-ene-3,3-dioxide

    NASA Astrophysics Data System (ADS)

    Arslan, Hakan; Demircan, Aydın; Göktürk, Ersen

    2008-01-01

    The IR spectra of 5-chloro-10-oxa-3-thia-tricyclo[5.2.1.0 1,5]dec-8-ene-3,3-dioxide (COTDO) has been recorded in the region 4000-525 cm -1. The optimized molecular geometry, frequency and intensity of the vibrational bands of COTDO in the ground state has been calculated using the Hartree-Fock and density functional using Becke's three-parameter hybrid method with the Lee, Yang, and Parr correlation functional methods with 6-31G(d,p) and 6-311G(d,p) basis sets. The harmonic vibrational frequencies were calculated and the scaled values have been compared with experimental IR spectra. The calculated geometrical parameters and harmonic vibrations are predicted in a very good agreement with the experimental data. The theoretical vibrational spectra of the title compound were interpreted by means of potential energy distributions (PEDs) using VEDA 4 program. With the help of this modern technique we were able to complete the assignment of the vibrational spectra of the title compound.

  12. 1 CFR 10.10 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 10.10 Section 10.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.10 Publication required. The Director of the...

  13. 1 CFR 10.10 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 10.10 Section 10.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.10 Publication required. The Director of the...

  14. 1 CFR 10.10 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 10.10 Section 10.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.10 Publication required. The Director of the...

  15. 1 CFR 10.10 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 10.10 Section 10.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.10 Publication required. The Director of the...

  16. 1 CFR 10.10 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 10.10 Section 10.10 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.10 Publication required. The Director of the...

  17. Megakaryocytic cells synthesize and platelets secrete alpha5-laminins, and the endothelial laminin isoform laminin 10 (alpha5beta1gamma1) strongly promotes adhesion but not activation of platelets.

    PubMed

    Nigatu, Ayele; Sime, Wondossen; Gorfu, Gezahegn; Geberhiwot, Tarekegn; Andurén, Ingegerd; Ingerpuu, Sulev; Doi, Masayuki; Tryggvason, Karl; Hjemdahl, Paul; Patarroyo, Manuel

    2006-01-01

    Following vascular injury, basement membrane (BM) components of the blood vessels are exposed to circulating cells and may contribute to hemostasis and/or thrombosis. Laminins 8 (LN-8) (alpha4beta1gamma1) and 10 (LN-10) (alpha5beta1gamma1) are major laminin isoforms of the endothelial BM, and LN-8 is also secreted by activated platelets. In the present study, we demonstrate synthesis of alpha5-laminins LN-10 and LN-11 (alpha5beta2gamma1) by megakaryocytic cells, and intracellular expression of these laminin isoforms in blood platelets. In contrast to platelet LN alpha4 chain that had an apparent molecular weight of 180 kDa and associated mostly to LNbeta1 chain, platelet LNalpha5 consisted of 300/350 kDa polypeptides and associated mainly to LNbeta2. Both alpha4- and alpha5-laminins were secreted by platelets following stimulation. When compared to recombinant human (rh) LN-8, rhLN-10 was much more adhesive to platelets, though adhesion to both proteins was largely mediated via alpha6beta1 integrin. In spite of their adhesive properties, rhLN-8 and rhLN-10 induced neither P-selectin expression nor cell aggregation, two signs of platelet activation. This study demonstrates synthesis/expression of heterotrimeric alpha5-laminins in hematopoietic/blood cells, and provides evidence for the adhesive, but not activating, role of endothelial laminin isoforms in platelet biology.

  18. 10 CFR 10.1 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Purpose. 10.1 Section 10.1 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.1 Purpose. (a) This...

  19. 10 CFR 10.1 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Purpose. 10.1 Section 10.1 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.1 Purpose. (a) This...

  20. 10 CFR 10.1 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Purpose. 10.1 Section 10.1 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.1 Purpose. (a) This...

  1. 10 CFR 10.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Purpose. 10.1 Section 10.1 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.1 Purpose. (a) This...

  2. 10 CFR 10.1 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Purpose. 10.1 Section 10.1 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE General Provisions § 10.1 Purpose. (a) This...

  3. KEY COMPARISON: Force key comparison CCM.F-K1.a and CCM.F-K1.b: 5 kN and 10 kN

    NASA Astrophysics Data System (ADS)

    Pusa, Aimo

    2009-01-01

    This report describes the key comparisons named CCM.F-K1.a and CCM.F-K1.b, for force with loads of 5 kN and 10 kN. The Draft A Report, reporting the measurement results of the key comparisons, has been accepted at the force expert group meeting in Pretoria on 23 March 2004. This became Part 1 of the preliminary Draft B Report. Then, there have been several discussions to find the best way for the determination of the reference value for force values 5 kN and 10 kN in the key comparisons CCM.F-K1.a and CCM.F-K1.b. Following the meeting held in Queretaro, Mexico, by CENAM, from 3 to 5 December 2007, the reference values have been calculated for each single transducer (see chapter 2), and as one reference value for 5 kN and a second reference value for 10 kN (see chapter 3). To get a better consistency a linear model for the drift of transducers has been applied. The results have been evaluated according to the paper from M G Cox, 'The evaluation of key comparison data' (2002 Metrologia 39 589-595). Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  4. 1.5-μm and 10-Gb s-1 etched mesa buried heterostructure DFB-LD for datacenter networks

    NASA Astrophysics Data System (ADS)

    Kwon, Oh Kee; Lee, Chul Wook; Leem, Young Ahn; Kim, Ki Soo; Oh, Su Hwan; Nam, Eun Soo

    2015-10-01

    We report a 1.5 μm and 10 Gb s-1 etched mesa buried heterostructure λ/4-shifted distributed feedback laser diode (DFB-LD) for the low-cost application of WDM-based datacenter networks. To reduce the threshold current and improve the modulation bandwidth in a conventional p-/n-/p-InP current blocking structure, a thin undoped-InP (u-InP) layer was inserted between the side walls of the active region and the p-InP layer (i.e., a u-/p-/n-/p-InP structure), and the region containing the active region and the current blocking structures was etched in a mesa form (i.e., an etched mesa). From this work, it was found that a 300 μm long anti-reflection (AR)-AR DFB-LD with a mesa width of 8 μm is reduced by about 25% while a side mode suppression ratio is >50 dB and a 3 dB bandwidth is >10 GHz at a current of 40 mA; in addition, it shows a clear eye-opening with a dynamic extinction ratio of >4.5 dB at 10 Gb s-1, and a power penalty of <1 dB after a 2 km transmission.

  5. Synthesis, crystal structure determination and antiproliferative activity of novel 2-amino-4-aryl-4,10-dihydro[1,3,5]triazino[1,2- a]benzimidazoles

    NASA Astrophysics Data System (ADS)

    Hranjec, Marijana; Pavlović, Gordana; Karminski-Zamola, Grace

    2012-01-01

    This manuscript describes the synthesis of novel 2-amino-4-aryl-4,10-dihydro-[1,3,5]triazino[1,2- a]benzimidazoles as hydrochloride salts 4a-n and 5b which were prepared in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatile heteroaromatic aldehydes. Structures of all prepared compounds have been studied by using 1H and 13C NMR, IR and UV/Vis spectroscopy. The crystal and molecular structure of 4f was determined by X-ray diffraction on single crystals. The molecule of 2-amino-4-(4'-methylphenyl)-4,10-dihydro[1,3,5]triazino[1,2- a]benzimidazole hydrochloride 4f (C 16H 16N 5+·Cl -) exists in the solid state in one of the possible tautomeric forms, being protonated at the one of the nitrogen atoms of the 1,4-dihydrotriazine ring. The molecule is highly delocalized within the 4,10-dihydro[1,3,5]triazino[1,2- a]benzimidazole moiety with the highest deviation from the plane for the methine carbon atom and the protonated nitrogen atom of the 1,4-dihydrotriazine ring. The cations are joined via N-H⋯N hydrogen bonds into R22(8) centrosymmetric dimers. Cation dimers are further connected with Cl - ions via N-H⋯Cl and C-H⋯Cl hydrogen bonds into 2D chains spreading along the b axis. The obtained single-crystal X-ray structure determination unequivocally confirms tautomeric form of the compound present in the solid-state and can represent tantative pattern for other prepared compounds. All prepared compounds were tested on their antiproliferative activity in vitro on several human cancer cell lines. Compound 4m was the most active one (IC 50 ≈ 20 μM), while compounds 4d, 4f, 4k, 4l4m showed moderate, but non-selective, antiproliferative activity with IC 50 25-60 μM.

  6. Multifunctional L1(0) -Mn(1.5)Ga films with ultrahigh coercivity, giant perpendicular magnetocrystalline anisotropy and large magnetic energy product.

    PubMed

    Zhu, Lijun; Nie, Shuaihua; Meng, Kangkang; Pan, Dong; Zhao, Jianhua; Zheng, Houzhi

    2012-08-28

    A new kind of multifunctional L1(0) -Mn(1.5)Ga film is demonstrated for the first time. These MBE-grown epitaxial films exhibit pronounced magnetic properties at room temperature, including ultrahigh perpendicular coercivity up to 42.8 kOe, giant perpendicular magnetic anisotropy with a maximum of 21.7 Merg/cm(3) and large magnetic energy products up to 2.60 MGOe, which allow various applications in ultrahigh density recording, spintronics, and permanent magnets.

  7. Syntheses of Anthracenones. 2. Preparation of 1,8-Dimethoxy- (Dimethylanthralin) and 4,5-Dihydroxy-9(10H)-anthracenone (Isoanthralin): A Revision.

    PubMed

    Prinz, Helge; Burgemeister, Thomas; Wiegrebe, Wolfgang; Müller, Klaus

    1996-04-19

    The reduction of 1,8-dimethoxyanthracenedione with zinc dust and aqueous ammonia gives a mixture of 1,8-dimethoxyanthracene and 4,5-dimethoxy-9(10H)-anthracenone, rather than the isomeric 1,8-dimethoxy-9(10H)-anthracenone (dimethylanthralin). This isomer was obtained exclusively using SnCl(2) in HCl and acetic acid as reducing agent at room temperature. The structure was confirmed to exist as the tautomeric 1,8-dimethoxy-9-hydroxyanthracene. Furthermore, the reduction of 1,8-diacetoxyanthracenedione with SnCl(2) in HCl and acetic acid leads to 1,8-dihydroxy-9(10H)-anthracenone (anthralin) rather than 4,5-dihydroxy-9(10H)-anthracenone (isoanthralin), which was prepared by ether cleavage of 4,5-dimethoxy-9(10H)-anthracenone. In light of these findings some biological studies on antipsoriatic anthracenones have to be reconsidered.

  8. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter....

  9. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter....

  10. 10 CFR 19.5 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 19.5 Section 19.5 Energy NUCLEAR... Communications. Except where otherwise specified in this part, all communications and reports concerning the... Regulatory Commission Regional Office listed in Appendix D of part 20 of this chapter....

  11. 10 CFR 5.405 - Housing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Housing. 5.405 Section 5.405 Energy NUCLEAR REGULATORY....405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply different rules or regulations, impose different fees or requirements, or offer different services or benefits related to...

  12. 10 CFR 5.405 - Housing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Housing. 5.405 Section 5.405 Energy NUCLEAR REGULATORY....405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply different rules or regulations, impose different fees or requirements, or offer different services or benefits related to...

  13. 10 CFR 5.405 - Housing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Housing. 5.405 Section 5.405 Energy NUCLEAR REGULATORY....405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply different rules or regulations, impose different fees or requirements, or offer different services or benefits related to...

  14. 10 CFR 5.405 - Housing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Housing. 5.405 Section 5.405 Energy NUCLEAR REGULATORY....405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply different rules or regulations, impose different fees or requirements, or offer different services or benefits related to...

  15. 10 CFR 5.405 - Housing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Housing. 5.405 Section 5.405 Energy NUCLEAR REGULATORY....405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply different rules or regulations, impose different fees or requirements, or offer different services or benefits related to...

  16. Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1), 10 (alpha5beta1gamma1).

    PubMed

    Wondimu, Zenebech; Gorfu, Gezahegn; Kawataki, Tomoyuki; Smirnov, Sergei; Yurchenco, Peter; Tryggvason, Karl; Patarroyo, Manuel

    2006-03-01

    Laminins, a family of large heterotrimeric (alphabetagamma) proteins, are major components of basement membranes implicated in a variety of cellular functions. Different commercial laminin preparations isolated from human placenta have been widely used in functional studies but their molecular properties are poorly known. In the present study, we characterized several of these preparations by ELISA, silver staining and Western blotting, in comparison to mouse laminin 1 (alpha1beta1gamma1), and recombinant human laminins 2 (alpha2beta1gamma1), 8 (alpha4beta1gamma1) and 10 (alpha5beta1gamma1). The cell migration-promoting activity of different batches was also tested. The placenta laminin preparations differed from one another and consisted of highly fragmented proteins, a mixture of laminin isoforms, and/or contaminating fibronectin. Major functional differences between batches were also observed, reflecting molecular heterogeneity. Previous data obtained in functional studies using these preparations need to be interpreted with caution and may require revision, and future functional studies demand prior molecular characterization of the laminins, particularly their alpha-chain.

  17. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  18. Body Weight Gain During a Discrete Nursing Episode in Suckling Rats Reared at 1.5-g or 1.5-g Exceeds that of 1.0-g Controls and is Independent of Material Hypergravity Exposure

    NASA Technical Reports Server (NTRS)

    Ronca, April E.; Baer, Lisa A.; Plaut, Karen; Wade, Charles E.; Sun, Sid (Technical Monitor)

    2001-01-01

    We recently reported that body weights of suckling rats reared during 1.5-g centrifugation are approximately 10% lower than those of 1.0-g controls. This finding raises the possibility that hypergravity exposed pups ingest less milk than controls due to either impairments in their ability to acquire milk from the nipple, or to decreased availability or palatability of their mother's milk. In the present study, we analyzed body weight gain in suckling rats reared during a discrete nursing episode following rearing at either 1.75-g, 1.5-g or 1.0-g. On Gestational day (G) 10 of the rats' 22-day pregnancy, time-bred SD rat dams were 1:1 matched based on body weight and assigned to either Hypergravity (HG) or Stationary Yoked Control (SYC) conditions and to either 1.75-g or 1.5-g conditions. Beginning on G11, HG dams and litters were exposed to 26 days of continuous centrifugation with brief daily stops for veterinary inspection and animal maintenance. On the day following birth (Postnatal day), litters were pooled within each condition then randomly re-assigned in equivalent proportions to HG and SYC dams. On P15, HG litters were removed from their mother's and placed in an incubator (33 C). Following a 4hr deprivation period, four neonates were tested from each litter, with two pups placed with either their own dam or the SYC dam; two pups from the yoked mother were paired with the HG pups. Pups were individually weighed, permitted to suckle for 75 min, then re-weighed. At the start of the test, the body weights of HG pups were significantly less than those of SYC pups (p less than 0.05). Relative to SYC pups, BG pups showed significantly greater proportional body weight gain (p less than 0.05), possibly due to augmented post-centrifugation feeding. Pup weight gain was independent of maternal hypergravity exposure. Neither impairments in milk acquisition nor milk availability or palatibility of hypergravity-exposed dams cannot account for reduced body mass of

  19. Ultrasonic Characterization of Microstructural Changes in Ti-10V-4.5Fe-1.5Al β-Titanium Alloy

    NASA Astrophysics Data System (ADS)

    Viswanath, A.; Kumar, Anish; Jayakumar, T.; Purnachandra Rao, B.

    2015-08-01

    Ultrasonic measurements have been carried out in Ti-10V-4.5Fe-1.5Al β-titanium alloy specimens subjected to β annealing at 1173 K (900 °C) for 1 hour followed by heat treatment in the temperature range of 823 K to 1173 K (550 °C to 900 °C) at an interval of 50 K (50 °C) for 1 hour, followed by water quenching. Ultrasonic parameters such as ultrasonic longitudinal wave velocity, ultrasonic shear wave velocity, shear anisotropy parameter, ultrasonic attenuation, and normalized nonlinear ultrasonic parameter have been correlated with various microstructural changes to understand the interaction of the propagating ultrasonic wave with microstructural features in the alloy. Simulation studies using JMatPro® software and X-ray diffraction measurements have been carried out to estimate the α-phase volume fraction in the specimens heat treated below the β-transus temperature (BTT). It is found that the α-phase (HCP) volume fraction increases from 0 to 52 pct, with decrease in the temperature from 1073 K to 823 K (800 °C to 550 °C). Ultrasonic longitudinal and shear wave velocities are found to increase with decrease in the heat treatment temperature below the BTT, and they exhibited linear relationships with the α-phase volume fraction. Thickness-independent ultrasonic parameters, Poisson's ratio, and the shear anisotropy parameter exhibited the opposite behavior, i.e., decrease with increase in the α-phase consequent to decrease in the heat treatment temperature from 1073 K to 823 K (800 °C to 550 °C). Ultrasonic attenuation is found to decrease from 0.7 dB/mm for the β-annealed specimen to 0.23 dB/mm in the specimen heat treated at 823 K (550 °C) due to the combined effect of the decrease in the β-phase (BCC) with higher damping characteristics and the reduction in scattering due to randomization of β grains with the precipitation of α-phase. Normalized nonlinear ultrasonic parameter is found to increase with increase in the α-phase volume fraction

  20. 17 CFR 240.10b5-1 - Trading “on the basis of” material nonpublic information in insider trading cases.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Deceptive Devices and Contrivances § 240.10b5-1 Trading “on the basis of” material nonpublic information in... in any other respect. (a) General. The “manipulative and deceptive devices” prohibited by Section...

  1. 17 CFR 240.10b5-1 - Trading “on the basis of” material nonpublic information in insider trading cases.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Deceptive Devices and Contrivances § 240.10b5-1 Trading “on the basis of” material nonpublic information in... in any other respect. (a) General. The “manipulative and deceptive devices” prohibited by Section...

  2. 17 CFR 240.10b5-1 - Trading “on the basis of” material nonpublic information in insider trading cases.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Deceptive Devices and Contrivances § 240.10b5-1 Trading “on the basis of” material nonpublic information in... in any other respect. (a) General. The “manipulative and deceptive devices” prohibited by Section...

  3. 17 CFR 240.10b5-1 - Trading “on the basis of” material nonpublic information in insider trading cases.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Deceptive Devices and Contrivances § 240.10b5-1 Trading “on the basis of” material nonpublic information in... in any other respect. (a) General. The “manipulative and deceptive devices” prohibited by Section...

  4. Granular superconductivity in polycrystalline ruthenocuprate RuSr2(Gd1.5Ce0.5)Cu2O10-δ: magnetoresistive and magnetization studies

    NASA Astrophysics Data System (ADS)

    Belevtsev, B. I.; Beliayev, E. Yu; Naugle, D. G.; Rathnayaka, K. D. D.; Anatska, M. P.; Felner, I.

    2007-01-01

    Granular superconductivity effects in polycrystalline samples of RuSr2(Gd1.5Ce0.5)Cu2O10-δ, as prepared (by a solid-state reaction method) and annealed (12 h at 845 °C) in pure oxygen at 30 atm, are presented. The resistive transition to the superconducting state of the as-prepared sample is found to be considerably affected by granularity. In particular, an evident kink in the temperature dependence of the resistance R(T) is seen at the temperature, Tc0ap34 K, at which grains become superconducting. The resistive transition depends strongly on the applied current. The family of R(T) curves taken for different transport currents is branched with a branching point at TcJap23.2 K. Below this temperature the intergrain Josephson coupling starts to develop. For low current, R decreases with decreasing temperature below TcJ as expected for the transition to the superconducting state, whereas R(T) curves for higher current form a minimum at Tap17.3 K, showing a quasi-re-entrant behaviour. The influence of the granular structure of the as-prepared sample shows itself also in the temperature behaviour of the magnetization, M(T), in low field. Application of low magnetic field (below 400 Oe) leads to a broadening of the resistive transitions below TcJ, similar to that caused by increasing the current. Both the current and magnetic field depress the Josephson coupling between the grains, producing a dramatically large effect on the resistive transition. The R(T) and M(T) dependences of the annealed sample show a fairly sharp superconducting transition far less affected by granularity. The results obtained imply that oxygen annealing improves the intergranular connection considerably, but it does not exert much influence on the intragrain superconductivity. No indication of intragrain granularity has been found in the samples studied. The influence of ageing (due to deoxidation) of samples for different conditions of storage is considered briefly as well.

  5. 46 CFR 59.10-5 - Cracks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Cracks. 59.10-5 Section 59.10-5 Shipping COAST GUARD... APPURTENANCES Welding Repairs to Boilers and Pressure Vessels in -Service § 59.10-5 Cracks. (a) Cracks extending... cracks are veed out so that complete penetration of the weld metal is secured. (b) Circumferential...

  6. 46 CFR 105.10-5 - Approved.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Approved. 105.10-5 Section 105.10-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Definition of Terms Used in This Part § 105.10-5 Approved. (a) The...

  7. PHASE EVOLUTION AND MICROWAVE DIELECTRIC PROPERTIES OF (Li0.5Bi0.5)(W1-xMox)O4(0.0 ≤ x ≤ 1.0) CERAMICS WITH ULTRA-LOW SINTERING TEMPERATURES

    NASA Astrophysics Data System (ADS)

    Zhou, Di; Guo, Jing; Yao, Xi; Pang, Li-Xia; Qi, Ze-Ming; Shao, Tao

    2012-11-01

    The (Li0.5Bi0.5)(W1-xMox)O4(0.0 ≤ x ≤ 1.0) ceramics were prepared via the solid state reaction method. The sintering temperature decreased almost linearly from 755°C for (Li0.5Bi0.5)WO4 to 560°C for (Li0.5Bi0.5)MoO4. When the x≤0.3, a wolframite solid solution can be formed. For x = 0.4 and x = 0.6 compositions, both the wolframite and scheelite phases can be formed from the X-ray diffraction analysis, while two different kinds of grains can be revealed from the scanning electron microscopy and energy-dispersive X-ray spectrometer results. High performance of microwave dielectric properties were obtained in the (Li0.5Bi0.5)(W0.6Mo0.4)O4 ceramic sintered at 620°C with a relative permittivity of 31.5, a Qf value of 8500 GHz (at 8.2 GHz), and a temperature coefficient value of +20 ppm/°C. Complex dielectric spectra of pure (Li0.5Bi0.5)WO4 ceramic gained from the infrared spectra were extrapolated down to microwave range, and they were in good agreement with the measured values. The (Li0.5Bi0.5)(W1-xMox)O4(0.0 ≤ x ≤ 1.0) ceramics might be promising for low temperature co-fired ceramic technology.

  8. Efficiency of Big Spring Number Eight (BSNE) and Modified Wilson and Cook (MWAC) samplers to collect PM10, PM2.5 and PM1

    NASA Astrophysics Data System (ADS)

    Mendez, Mariano J.; Funk, Roger; Buschiazzo, Daniel E.

    2016-06-01

    The internal efficiency of Big Spring Number Eight (BSNE) and Modified Wilson and Cook (MWAC) samplers for trapping PM10, PM2.5 and PM1 were tested in a wind tunnel, at two wind speeds (3.0 and 6.8 m s-1) in the saltation zone (SAZ) and the suspension zone (SAZ). PM concentrations measured in the inlet and the outlet of both samplers were correlated and the slopes of fitting equations were used for calculating sampling efficiencies. Results showed that BSNE efficiencies ranged from 12% to 32% for PM10, from 0% to 19% for PM2.5 and from 0% to 12% for PM1. The BSNE's efficiency decreased with decreasing particle sizes in SAZ and SUZ at both wind speeds as a consequence of the very low deposition velocity of the finest size particles. The BSNE's efficiency increased with increasing wind speed in SAZ for PM10 and PM2.5 and in SUZ for PM2.5. The MWAC's efficiency ranged from 1% to 20% for PM10, from 0% to 15% for PM2.5 and from 0% to 16% for PM1. The MWAC efficiency was 0% for PM10, PM2.5 and PM1 in the SUZ at 3 m s-1 and for PM2.5 and PM1 in the SUZ at 6.8 m s-1. These results provide evidence that the efficiency of BSNE and MWAC for trapping PM10 change with wind speed and position of the sampler. Results also show that BSNEs and MWACs can potentially be used for PM10 emission studies but more research is needed in order to understand and improve their efficiency.

  9. Pathways to quiescence: SHARDS view on the star formation histories of massive quiescent galaxies at 1.0 < z < 1.5

    NASA Astrophysics Data System (ADS)

    Domínguez Sánchez, Helena; Pérez-González, Pablo G.; Esquej, Pilar; Eliche-Moral, M. Carmen; Barro, Guillermo; Cava, Antonio; Koekemoer, Anton M.; Alcalde Pampliega, Belén; Alonso Herrero, Almudena; Bruzual, Gustavo; Cardiel, Nicolás; Cenarro, Javier; Ceverino, Daniel; Charlot, Stéphane; Hernán Caballero, Antonio

    2016-04-01

    We present star formation histories (SFHs) for a sample of 104 massive (stellar mass M > 1010 M⊙) quiescent galaxies (MQGs) at z = 1.0-1.5 from the analysis of spectrophotometric data from the Survey for High-z Absorption Red and Dead Sources (SHARDS) and HST/WFC3 G102 and G141 surveys of the GOODS-North field, jointly with broad-band observations from ultraviolet (UV) to far-infrared (far-IR). The sample is constructed on the basis of rest-frame UVJ colours and specific star formation rates (sSFRs = SFR/Mass). The spectral energy distributions (SEDs) of each galaxy are compared to models assuming a delayed exponentially declining SFH. A Monte Carlo algorithm characterizes the degeneracies, which we are able to break taking advantage of the SHARDS data resolution, by measuring indices such as MgUV and D4000. The population of MQGs shows a duality in their properties. The sample is dominated (85 per cent) by galaxies with young mass-weighted ages, overline{t_M} < 2 Gyr, short star formation time-scales, <τ> ˜ 60-200 Myr, and masses log(M/M⊙) ˜ 10.5. There is an older population (15 per cent) with overline{t_M} = 2-4 Gyr, longer star formation time-scales, <τ> ˜ 400 Myr, and larger masses, log(M/M⊙) ˜ 10.7. The SFHs of our MQGs are consistent with the slope and the location of the main sequence of star-forming galaxies at z > 1.0, when our galaxies were 0.5-1.0 Gyr old. According to these SFHs, all the MQGs experienced a luminous infrared galaxy phase that lasts for ˜500 Myr, and half of them an ultraluminous infrared galaxy phase for ˜100 Myr. We find that the MQG population is almost assembled at z ˜ 1, and continues evolving passively with few additions to the population.

  10. Groundwater Classification Document Fort Sheridan, Illinois, Volume 1, Sections 1.0 - 6.0 and Appendicies A - B/GEA5.

    DTIC Science & Technology

    2007-11-02

    corrected based on the laboratory data and feedback was provided to the field geologist/engineer. A table summarizing the physical analysis data and...8217< Day: trace *it =nd fine gravel, cark 5-rown (I0YR4/3) -ith *::Bes yetowish ’ efl (10YR5/8) and grey (!GYn5/<). aedua plasticity, hard, moist. no

  11. catena-Poly[[bis­[4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol]cadmium(II)]-μ-fumarato

    PubMed Central

    Shi, Li-Ping; Tiekink, Edward R. T.

    2009-01-01

    In the polymeric title compound, [Cd(C4H2O4)(C19H12N4O)2]n, the CdII centre is eight-coordinated within an N4O4 donor set derived from two chelating 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol ligands and two asymmetrically chelating carboxyl­ate residues of bridging fumarate dianions. The linear chains are linked into a layer in the ac plane via O—H⋯Ocarboxyl­ate hydrogen bonds. Layers are connected into double layers via N—H⋯Ocarboxyl­ate hydrogen bonds and these stack along the b axis. C—H⋯π inter­actions are also present. Disorder in the ethyl­ene portion of the fumarate was modelled over two positions, the major component having a site-occupancy factor of 0.677 (15). PMID:21583349

  12. Multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 layers for tunable applications.

    PubMed

    Yu, Shihui; Li, Lingxia; Zhang, Weifeng; Sun, Zheng; Dong, Helei

    2015-05-11

    The dielectric properties and tunability of multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 (PZT/BZN) layers (PPBLs) fabricated by pulsed laser deposition on Pt/TiO2/SiO2/Si substrate have been investigated. Dielectric measurements indicate that the PZT/BZN bilayer thin films exhibit medium dielectric constant of about 490, low loss tangent of 0.017, and superior tunable dielectric properties (tunability=49.7% at 500 kV/cm) at a PZT/BZN thickness ratio of 3, while the largest figure of merit is obtained as 51.8. The thickness effect is discussed with a series connection model of bilayer capacitors, and the calculated dielectric constant and loss tangent are obtained. Furthermore, five kinds of thin-film samples comprising single bilayers, two, three, four and five PPBLs were also elaborated with the final same thickness. The four PPBLs show the largest dielectric constant of ~538 and tunability of 53.3% at a maximum applied bias field of 500 kV/cm and the lowest loss tangent of ~0.015, while the largest figure of merit is 65.6. The results indicate that four PPBLs are excellent candidates for applications of tunable devices.

  13. Effect of process parameters and post-deposition annealing on the microwave dielectric and optical properties of pulsed laser deposited Bi1.5Zn1.0Nb1.5O7 thin films

    NASA Astrophysics Data System (ADS)

    Sudheendran, K.; Ghanashyam Krishna, M.; Raju, K. C. James

    2009-05-01

    Bismuth Zinc niobate (Bi1.5Zn1.0Nb1.5O7) thin films were deposited by pulsed laser deposition (PLD) method on fused silica substrates at different oxygen pressures. The structural, microwave dielectric and optical properties of these thin films were systematically studied for both the as-deposited and the annealed films at 600°C. The as-deposited films were all amorphous in nature but crystallized on annealing at 600°C in air. The surface morphology as studied by atomic force microscopy (AFM) reveals ultra-fine grains in the case of as-deposited thin films and cluster grain morphology on annealing. The as-deposited films exhibit refractive index in the range of 2.36-2.53 (at a wavelength of 750 nm) with an optical absorption edge value of 3.30-3.52 eV and a maximum dielectric constant of 11 at 12.15 GHz. On annealing the films at 600°C they crystallize to the cubic pyrochlore structure accompanied by an increase in band gap, refractive index and microwave dielectric constant.

  14. Multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 layers for tunable applications

    NASA Astrophysics Data System (ADS)

    Yu, Shihui; Li, Lingxia; Zhang, Weifeng; Sun, Zheng; Dong, Helei

    2015-05-01

    The dielectric properties and tunability of multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 (PZT/BZN) layers (PPBLs) fabricated by pulsed laser deposition on Pt/TiO2/SiO2/Si substrate have been investigated. Dielectric measurements indicate that the PZT/BZN bilayer thin films exhibit medium dielectric constant of about 490, low loss tangent of 0.017, and superior tunable dielectric properties (tunability = 49.7% at 500 kV/cm) at a PZT/BZN thickness ratio of 3, while the largest figure of merit is obtained as 51.8. The thickness effect is discussed with a series connection model of bilayer capacitors, and the calculated dielectric constant and loss tangent are obtained. Furthermore, five kinds of thin-film samples comprising single bilayers, two, three, four and five PPBLs were also elaborated with the final same thickness. The four PPBLs show the largest dielectric constant of ~538 and tunability of 53.3% at a maximum applied bias field of 500 kV/cm and the lowest loss tangent of ~0.015, while the largest figure of merit is 65.6. The results indicate that four PPBLs are excellent candidates for applications of tunable devices.

  15. Multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 layers for tunable applications

    PubMed Central

    Yu, Shihui; Li, Lingxia; Zhang, Weifeng; Sun, Zheng; Dong, Helei

    2015-01-01

    The dielectric properties and tunability of multilayer thin films with compositional PbZr0.52Ti0.48O3/Bi1.5Zn1.0Nb1.5O7 (PZT/BZN) layers (PPBLs) fabricated by pulsed laser deposition on Pt/TiO2/SiO2/Si substrate have been investigated. Dielectric measurements indicate that the PZT/BZN bilayer thin films exhibit medium dielectric constant of about 490, low loss tangent of 0.017, and superior tunable dielectric properties (tunability = 49.7% at 500 kV/cm) at a PZT/BZN thickness ratio of 3, while the largest figure of merit is obtained as 51.8. The thickness effect is discussed with a series connection model of bilayer capacitors, and the calculated dielectric constant and loss tangent are obtained. Furthermore, five kinds of thin–film samples comprising single bilayers, two, three, four and five PPBLs were also elaborated with the final same thickness. The four PPBLs show the largest dielectric constant of ~538 and tunability of 53.3% at a maximum applied bias field of 500 kV/cm and the lowest loss tangent of ~0.015, while the largest figure of merit is 65.6. The results indicate that four PPBLs are excellent candidates for applications of tunable devices. PMID:25960043

  16. Indico 1.0

    NASA Astrophysics Data System (ADS)

    Gonzalez Lopez, J. B.; Avilés, A.; Baron, T.; Ferreira, P.; Kolobara, B.; Pugh, M. A.; Resco, A.; Trzaskoma, J. P.

    2014-06-01

    Indico has evolved into the main event organization software, room booking tool and collaboration hub for CERN. The growth in its usage has only accelerated during the past 9 years, and today Indico holds more that 215,000 events and 1,100,000 files. The growth was also substantial in terms of functionalities and improvements. In the last year alone, Indico has matured considerably in 3 key areas: enhanced usability, optimized performance and additional features, especially those related to meeting collaboration. Along the course of 2012, much activity has centred around consolidating all this effort and investment into "version 1.0", recently released in 2013.Version 1.0 brings along new features, such as the Microsoft Exchange calendar synchronization for participants, many new and clean interfaces (badges and poster generation, list of contributions, abstracts, etc) and so forth. But most importantly, it brings a message: Indico is now stable, consolidated and mature after more than 10 years of non-stop development. This message is addressed not only to CERN users but also to the many organisations, in or outside HEP, which have already installed the software, and to others who might soon join this community. In this document, we describe the current state of the art of Indico, and how it was built. This does not mean that the Indico software is complete, far from it! We have plenty of new ideas and projects that we are working on and which we have shared during CHEP 2013.

  17. Effect of annealing temperature of Bi1.5Zn1.0Nb1.5O7 gate insulator on performance of ZnO based thin film transistors

    NASA Astrophysics Data System (ADS)

    Wei, Ye; Wei, Ren; Peng, Shi; Zhuangde, Jiang

    2016-07-01

    The bottom-gate structure ZnO based thin film transistors (ZnO-TFTs) using Bi1.5Zn1.0Nb1.5O7 (BZN) thin films as gate insulator were fabricated on Pt/SiO2/Si substrate by radio frequency magnetic sputtering. We investigated the effect of annealing temperature at 300, 400, and 500 °C on the performance of BZN thin films and ZnO-TFTs. XRD measurement confirmed that BZN thin films were amorphous in nature. BZN thin films annealed at 400 °C obtain the high capacitance density of 249 nF/cm2, high dielectric constant of 71, and low leakage current density of 10-7 A/cm2 on/off current ratio and field effect mobility of ZnO-TFTs annealed at 400 °C are approximately one order of magnitude and two times, respectively higher than that of ZnO-TFTs annealed at 300 °C. When the annealing temperature is 400 °C, the electrical performance of ZnO-TFTs is enhanced remarkably. Devices obtain a low sub-threshold swing of 470 mV/dec and surface states density of 3.21 × 1012cm-2. Project supported by the National Natural Science Foundation of China (Nos. 51332003, 51202184), the International Science & Technology Cooperation Program of China (Nos. 2010DFB13640, 2011DFA51880), and the “111 Project” of China (No. B14040).

  18. UV-visible spectroscopic and electrochemical study of the complex formation between Fe(II) and 5-amino-1,10-phenantroline (5-Aphen) in aqueous solution.

    PubMed

    Lozano-Camargo, María Luisa; Rojas-Hernández, Alberto; Gómez-Hernández, Martín; Pacheco-Hernández, Ma de Lourdes; Galicia, Laura; Ramírez-Silva, María Teresa

    2007-06-15

    The system Fe(II)-5-Aphen-H(2)O was studied. The spectroscopic and electrochemical results show that only one stable complex between Fe(II) and 5-Aphen forms, having a 1:3 stoichiometric ratio. The spectrophotometry study allowed determination of the formation constant of the complex (logbeta(3)=23.42+/-0.06). Also, the stability of the complex was evaluated as a function of pH; it was found that it decomposed at low pH values depending on the concentration and a pseudo-first order kinetics constant associated with k'=0.011min(-1). The results are in agreement with the electrochemical behaviour observed in the system, which indicated that at pH 1.33 the destruction of the complex [Fe(5-Aphen)3](2+) took place as a function of time; however, when the experiments were carried out at pH 6.19 the complex was stable. The thermodynamic data obtained through the use of MEDUSA allowed construction of predominance zone diagrams of the system Fe(II)-5-Aphen-H(2)O under the experimental conditions used. The thermodynamic results represented in the PZD describe the experimental behaviour reported in this work.

  19. [Pharmacological and toxicological investigation of 2,2-diethyl-2,3,5,10-tetrahydro-1H-pyrazolo(1,2-b)phthalazine-1,3-dione, a new compound with anti-inflammatory activity].

    PubMed

    Dalla Vedova, R; Cadel, S; D'Alò, G

    1980-06-01

    As part of research on 1H-pyrazole[1,2-b]phthalazine compounds with anti-inflammatory activity, the results of preliminary pharmacological and toxicological investigation of 2,2-diethyl-2,2,5,10-tetrahydro-1H-pyrazolo[1,2-b]phthalazine-1,3-dione are reported.

  20. IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients

    PubMed Central

    Chen, Ying; Li, Chao; Lu, Yiping; Zhuang, Huiying; Gu, Weijia; Liu, Bo; Liu, Fangwei; Sun, Jinkai; Yan, Bo; Weng, Dong; Chen, Jie

    2017-01-01

    Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1dhiCD5+ Bregs, not IL-10-producing non-B lymphocytes, was significantly higher in SP compared to subjects under surveillance (SS) and healthy workers (HW) by flow cytometry. We also found that regulatory T cells (Tregs) and Th2 cytokines (IL-4, IL-5, and IL-13) were significantly increased in SP. Th1 cytokines (IFN-γ, IL-2, and IL-12) and inflammatory cytokines (IL-1β, IL-6, and TNF-α) were not significantly different between SP, SS, and HW. Our study indicated that IL-10-producing CD1dhiCD5+ Bregs might maintain Tregs and regulate Th1/Th2 polarization in SP, suggesting that IL-10-producing Bregs may play a critical role in modulating immune homeostasis in SP. PMID:28243231

  1. Use of a pitot-static probe for determining wing section drag in flight at Mach numbers from 0.5 to approximately 1.0

    NASA Technical Reports Server (NTRS)

    Montoya, L. C.; Economu, M. A.; Cissell, R. E.

    1974-01-01

    The use of a pitot-static probe to determine wing section drag at speeds from Mach 0.5 to approximately 1.0 was evaluated in flight. The probe unit is described and operational problems are discussed. Typical wake profiles and wing section drag coefficients are presented. The data indicate that the pitot-static probe gave reliable results up to speeds of approximately 1.0.

  2. The Possibility of Using as a Photogrammetric Base the 1:25,000 Map for Photogrammetric Mapping at Scales of 1:10,000 and 1:5,000 -- Czechoslovakia --

    DTIC Science & Technology

    2015-08-25

    MAPPING AT SCALES OF 1:10,000 AND lr.5,000 ; .• ,’ j L ~c.:...:; ;"": - Czechoslovakia - by Vaclav Pichlik ~ \\ ’, ~;~·--"’ ,~· :.. :.!, j...25,000 HAP FOR PHCTOGRAPETRIC MAPPHG AT SCALES OF Is 10,000 AND 1:5,000 [Following is a translation of an article by Vaclav PichHk inX Czechoslovak...Czechoslovakia, as soon as mapping at ^e 1.25,000 sc-w « completed, «oik started on topographic napping at the 1:10,000 scale and in some localities

  3. Theoretical investigations of a high density cage compound 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane.

    PubMed

    Zhang, Jian-ying; Du, Hong-chen; Wang, Fang; Gong, Xue-dong; Huang, Yin-sheng

    2012-01-01

    A new polynitro cage compound with the framework of HNIW and a tetrazole unit, i.e., 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane (NTz-HNIW) has been proposed and studied by density functional theory (DFT) and molecular mechanics methods. Properties such as IR spectrum, heat of formation, thermodynamic properties, and crystal structure were predicted. The compound belongs to the Pbca space group, with the lattice parameters a = 15.07 Å, b = 12.56 Å, c = 18.34 Å, Z = 8, and ρ = 1.990 g·cm(-3). The stability of the compound was evaluated by the bond dissociation energies and results showed that the first step of pyrolysis is the rupture of the N-NO(2) bond in the side chain. The detonation properties were estimated by the Kamlet-Jacobs equations based on the calculated crystal density and heat of formation, and the results were 9.240 km·s(-1) for detonation velocity and 40.136 GPa for detonation pressure. The designed compound has high thermal stability and good detonation properties and is probably a promising high energy density compound (HEDC).

  4. The electrochemical behaviors of Mg-8Li-3Al-0.5Zn and Mg-8Li-3Al-1.0Zn in sodium chloride solution

    NASA Astrophysics Data System (ADS)

    Lv, Yanzhuo; Liu, Min; Xu, Yan; Cao, Dianxue; Feng, Jing

    2013-03-01

    The electrochemical oxidation behaviors of Mg-8Li-3Al-0.5Zn and Mg-8Li-3Al-1.0Zn electrodes in 0.7 mol L-1 NaCl solution are investigated by methods of potentiodynamic polarization, potentiostatic oxidation, electrochemical impedance spectroscopy and scanning electron microscopy. The phase composition of Mg-8Li-3Al-0.5Zn and Mg-8Li-3Al-1.0Zn alloys is analyzed conducted by X-ray diffraction. The performances of Mg-8Li-3Al-0.5Zn and Mg-8Li-3Al-1.0Zn as the anode of Mg-H2O2 semi fuel cells are determined. The effect of Zn content on the corrosion resistant of these Mg-Li-based alloys is studied. It is found that the Mg-8Li-3Al-0.5Zn electrode has higher discharge activity and less corrosion resistance than that of Mg-8Li-3Al-1.0Zn electrode in 0.7 mol L-1 NaCl solution. The Mg-H2O2 semi fuel cell with Mg-8Li-3Al-0.5Zn anode presents a maximum power density of 100 mW cm-2 at room temperature, which is higher than that of Mg-8Li-3Al-1.0Zn anode (80 mW cm-2). The performance of semi fuel cell with the Mg-8Li-3Al-0.5Zn electrode is better than that with Mg-8Li-3Al-1.0Zn electrode, especially at higher current density (>30 mA cm-2).

  5. 10 CFR 960.5-2-10 - Hydrology.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Hydrology. 960.5-2-10 Section 960.5-2-10 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Ease and Cost of Siting, Construction, Operation, and Closure §...

  6. 10 CFR 960.5-2-10 - Hydrology.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Hydrology. 960.5-2-10 Section 960.5-2-10 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Ease and Cost of Siting, Construction, Operation, and Closure §...

  7. 10 CFR 960.5-2-10 - Hydrology.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Hydrology. 960.5-2-10 Section 960.5-2-10 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Ease and Cost of Siting, Construction, Operation, and Closure §...

  8. 10 CFR 960.5-2-10 - Hydrology.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Hydrology. 960.5-2-10 Section 960.5-2-10 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Ease and Cost of Siting, Construction, Operation, and Closure §...

  9. Peptide-Derivatized SB105-A10 Dendrimer Inhibits the Infectivity of R5 and X4 HIV-1 Strains in Primary PBMCs and Cervicovaginal Histocultures

    PubMed Central

    Bon, Isabella; Lembo, David; Rusnati, Marco; Clò, Alberto; Morini, Silvia; Miserocchi, Anna; Bugatti, Antonella; Grigolon, Sonia; Musumeci, Giuseppina; Landolfo, Santo; Re, Maria Carla; Gibellini, Davide

    2013-01-01

    Peptide dendrimers are a class of molecules that exhibit a large array of biological effects including antiviral activity. In this report, we analyzed the antiviral activity of the peptide-derivatized SB105-A10 dendrimer, which is a tetra-branched dendrimer synthetized on a lysine core, in activated peripheral blood mononuclear cells (PBMCs) that were challenged with reference and wild-type human immunodeficiency virus type 1 (HIV-1) strains. SB105-A10 inhibited infections by HIV-1 X4 and R5 strains, interfering with the early phases of the viral replication cycle. SB105-A10 targets heparan sulfate proteoglycans (HSPGs) and, importantly, the surface plasmon resonance (SPR) assay revealed that SB105-A10 strongly binds gp41 and gp120, most likely preventing HIV-1 attachment/entry through multiple mechanisms. Interestingly, the antiviral activity of SB105-A10 was also detectable in an organ-like structure of human cervicovaginal tissue, in which SB105-A10 inhibited the HIV-1ada R5 strain infection without altering the tissue viability. These results demonstrated the strong antiviral activity of SB105-A10 and suggest a potential microbicide use of this dendrimer to prevent the heterosexual transmission of HIV-1. PMID:24116111

  10. Blind Detections of CO J = 1-0 in 11 H-ATLAS Galaxies at z = 2.1-3.5 with the GBT/Zpectrometer

    NASA Astrophysics Data System (ADS)

    Harris, A. I.; Baker, A. J.; Frayer, D. T.; Smail, Ian; Swinbank, A. M.; Riechers, D. A.; van der Werf, P. P.; Auld, R.; Baes, M.; Bussmann, R. S.; Buttiglione, S.; Cava, A.; Clements, D. L.; Cooray, A.; Dannerbauer, H.; Dariush, A.; De Zotti, G.; Dunne, L.; Dye, S.; Eales, S.; Fritz, J.; González-Nuevo, J.; Hopwood, R.; Ibar, E.; Ivison, R. J.; Jarvis, M. J.; Maddox, S.; Negrello, M.; Rigby, E.; Smith, D. J. B.; Temi, P.; Wardlow, J.

    2012-06-01

    We report measurements of the carbon monoxide ground state rotational transition (12C16O J = 1-0) with the Zpectrometer ultrawideband spectrometer on the 100 m diameter Green Bank Telescope. The sample comprises 11 galaxies with redshifts between z = 2.1 and 3.5 from a total sample of 24 targets identified by Herschel-ATLAS photometric colors from the SPIRE instrument. Nine of the CO measurements are new redshift determinations, substantially adding to the number of detections of galaxies with rest-frame peak submillimeter emission near 100 μm. The CO detections confirm the existence of massive gas reservoirs within these luminous dusty star-forming galaxies (DSFGs). The CO redshift distribution of the 350 μm selected galaxies is strikingly similar to the optical redshifts of 850 μm-selected submillimeter galaxies in 2.1 <= z <= 3.5. Spectroscopic redshifts break a temperature-redshift degeneracy; optically thin dust models fit to the far-infrared photometry indicate characteristic dust temperatures near 34 K for most of the galaxies we detect in CO. Detections of two warmer galaxies, and statistically significant nondetections, hint at warmer or molecule-poor DSFGs with redshifts that are difficult to determine from Herschel-SPIRE photometric colors alone. Many of the galaxies identified by H-ATLAS photometry are expected to be amplified by foreground gravitational lenses. Analysis of CO linewidths and luminosities provides a method for finding approximate gravitational lens magnifications μ from spectroscopic data alone, yielding μ ~ 3-20. Corrected for magnification, most galaxy luminosities are consistent with an ultraluminous infrared galaxy classification, but three are candidate hyper-LIRGs with luminosities greater than 1013 L ⊙.

  11. Chromophore-modified antitumor anthracenediones: synthesis, DNA binding, and cytotoxic activity of 1,4-bis[(aminoalkyl)amino]benzo[g]-phthalazine-5,10-diones.

    PubMed

    Gandolfi, C A; Beggiolin, G; Menta, E; Palumbo, M; Sissi, C; Spinelli, S; Johnson, F

    1995-02-03

    As part of a program aimed at exploring the effect of the introduction of heteroatoms into the anthracene-9,10-dione chromophore, we have synthesized novel 1,4-bis[(aminoalkyl)amino]-benzo[g]phthalazine-5,10-diones (BPDs) 1 which are related to the antitumor agents ametantrone and mitoxantrone. Derivatives 1 were prepared by chromic acid oxidation of acylated benzo[g]phthalazines 5 followed by acid hydrolysis or by silylation-amination of 5,10-dihydroxybenzo[g]phthalazine-1,4-dione (8). The 1-[(aminoalkyl)amino]-4-amino congeners 2 were isolated in low yields as byproducts from the oxidation of 5. Against a panel of human tumor cell lines, the benzo[g]phthalazine-5,10-diones 1 and 2 exhibited cytotoxic activity comparable or even superior to that of mitoxantrone. In compounds 1, structure-activity relationships different than those operative in the carbocyclic series appeared to emerge. DNA-binding studies with the ametantrone-like compound 1c and its single-armed congener 2c indicated that the introduction of a 2,3-diaza subunit into the anthracene-9,10-dione chromophore reduces the affinity of the drug for DNA in comparison with ametantrone. On the other hand, the number of side-chain groups does not affect binding to a great extent. These findings seem to suggest mechanisms of cell death other than those induced by simple interaction of the 1,4-BPDs 1 and 2 with DNA.

  12. Advances in Classification Research. Volume 10. Proceedings of the ASIS SIG/CR Classification Research Workshop (10th, Washington, DC, November 1-5, 1999). ASIST Monograph Series.

    ERIC Educational Resources Information Center

    Albrechtsen, Hanne, Ed.; Mai, Jens-Erik, Ed.

    This volume is a compilation of the papers presented at the 10th ASIS (American Society for Information Science) workshop on classification research. Major themes include the social and cultural informatics of classification and coding systems, subject access and indexing theory, genre analysis and the agency of documents in the ordering of…

  13. Syntheses, structures and photoluminescent properties of three d{sup 10} coordination architectures based on in-situ 1,3,5-triazine derivatives

    SciTech Connect

    Xiao, Changyu; Li, Yamin; Lun, Huijie; Cui, Caiyan; Xu, Yanqing

    2013-12-15

    In the presence of aromatic carboxylic acids, three new d{sup 10} transition metal coordination polymers, [Ag(PAHT)]{sub n}(1), [Ag{sub 2}(HCA)]{sub n}(2) and [Cu{sub 6}(CA){sub 2}(H{sub 2}O)]{sub n}(3) (HPAHT=2-phenyl-4-amino-6-hydroxy-1,3,5-triazine, H{sub 3}CA=cyanuric acid) have been synthesized based on in-situ 1,3,5-triazine derivatives resulting from 2,4-diamino-6-phenyl-1,3,5-triazine, 2-chloro-4,6-diamino-1,3,5-triazine and melamine under hydrothermal conditions. Complexes 1–3 have been characterized by single-crystal X-ray diffraction, IR spectra, elemental analysis and thermogravimetric analysis (TGA). The compound 1 exhibits a uninodal three-connected 3D network with a rare lig LiGe type topology, which contains right-handed and left-handed [Ag(PAHT)]{sub n} helical chains. For compound 2, the 3D network is comprised of 2D sheet by strongly Ag–O and weakly Ag(I)…Ag(I) interactions. In compound 3, it is infrequently observed that dodecanuclear copper(I) units as secondary building units (SBUs) construct 3D network by the ligands CA{sup 3−} with a rare uninodal 10-connected bct topology (3{sup 12}.4{sup 28}.5{sup 5}). The photoluminescent properties of three compounds have also been measured. - Graphical abstract: Three d{sup 10} transition metal coordination polymers 1–3 have been hydrothermally synthesized and characterized by single-crystal X-ray diffraction, IR spectra, elemental analysis, photoluminescent spectra and thermogravimetric analysis (TGA). - Highlights: • The compound 1 exhibits a new 3D network with two kinds of single helical chains. • New 3D d{sup 10} transition metal coordination polymers. • The photoluminescent properties have been measured.

  14. 45 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Parents and guardians. 5b.10 Section 5b.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the...

  15. 45 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Parents and guardians. 5b.10 Section 5b.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the...

  16. 45 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Parents and guardians. 5b.10 Section 5b.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the...

  17. 45 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Parents and guardians. 5b.10 Section 5b.10 Public Welfare Department of Health and Human Services GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the...

  18. 46 CFR 30.10-5 - Cargo-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo-TB/ALL. 30.10-5 Section 30.10-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-5 Cargo—TB/ALL. The term cargo means combustible liquid, flammable liquid, or liquefied flammable gas...

  19. 46 CFR 30.10-5 - Cargo-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Cargo-TB/ALL. 30.10-5 Section 30.10-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-5 Cargo—TB/ALL. The term cargo means combustible liquid, flammable liquid, or liquefied flammable gas...

  20. DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

    PubMed Central

    Flatau, E; Gonzales, F A; Michalowsky, L A; Jones, P A

    1984-01-01

    A cell line (T17) was derived from C3H 10T1/2 C18 cells after 17 treatments with increasing concentrations of 5-aza-2'-deoxycytidine. The T17 cell line was very resistant to the cytotoxic effects of 5-aza-2'-deoxycytidine, and the 50% lethal dose for 5-aza-2'-deoxycytidine was ca. 3 microM, which was 30-fold greater than that of the parental C3H 10T1/2 C18 cells. Increased drug resistance was not due to a failure of the T17 cell line to incorporate 5-aza-2'-deoxycytidine into DNA. The cells were also slightly cross-resistant to 5-azacytidine. The percentage of cytosines modified to 5-methylcytosine in T17 cells was 0.7%, a 78% decrease from the level of 3.22% in C3H 10T1/2 C18 cells. The DNA cytosine methylation levels in several clones isolated from the treated lines were on the order of 0.7%, and clones with methylation levels lower than 0.45% were not obtained even after further drug treatments. These highly decreased methylation levels appeared to be unstable, and DNA modification increased as the cells divided in the absence of further drug treatment. The results suggest that it may not be possible to derive mouse cells with vanishingly low levels of 5-methylcytosine and that considerable de novo methylation can occur in cultured lines. PMID:6209556

  1. Effects of 2.1 and 3.5x10(6) sex-sorted sperm dosages on conception rates of Holstein cows and heifers.

    PubMed

    DeJarnette, J M; McCleary, C R; Leach, M A; Moreno, J F; Nebel, R L; Marshall, C E

    2010-09-01

    The objective was to compare conceptions rates of Holstein cows and heifers after artificial insemination (AI) with 2.1 or 3.5x10(6) sex-sorted sperm or 15x10(6) conventional sperm. Ejaculates collected from 7 Holstein sires were cryopreserved conventionally at 15x10(6) sperm per dose or sorted to 90% purity for X-chromosome-bearing spermatozoa using flow cytometry and cryopreserved at either 2.1 or 3.5x10(6) sperm per dose. All treatments were processed in an egg-yolk (20%), Tris, glycerol (7%) extender and packaged in color-coded 0.25-mL French straws. Straws (n=700 straws/dosage per sire) were packaged and distributed in aliquots of 12 (4 straws/sperm dosage) to 69 Holstein herds with an across-herd goal of achieving approximately 50% use in heifers and cows. Straw color was recorded in the on-farm recordkeeping system at the time of AI and retrieved by electronic download. Data for cows and heifers were analyzed separately. Among heifers, 6,268 services were retrieved from 45 herds (298+/-4.2 services/sperm dose per sire; range: 244 to 344). Conception rate of heifers was influenced by the sire by treatment interaction. Conception rate of the 2.1 and 3.5x10(6) sex-sorted sperm dosages were comparable in 6 of 7 sires. Conception rate of both sex-sorted dosages were less than those of conventional semen for 6 of 7 sires. Across sires, heifer conception rates for 2.1 and 3.5x10(6) sex-sorted sperm dosages and 15x10(6) conventional dosages were 44, 46, and 61%, respectively. Among cows, 5,466 services were retrieved from 52 herds (260+/-3.3 services/sperm dose per sire; range: 236 to 289). Conception rates of cows were influenced by herd, sire, and sperm dosage. Conception rates of the 2.1 and 3.5x10(6) sex-sorted sperm dosage were comparable for all 7 sires. Conception rates of 2.1x10(6) sex-sorted sperm dosage were less than those of conventional semen for 4 of 7 sires and conception rates of the 3.5x10(6) sex-sorted sperm dosage were less than those of

  2. Spectral characterization of novel ternary zinc(II) complexes containing 1,10-phenanthroline and Schiff bases derived from amino acids and salicylaldehyde-5-sulfonates

    NASA Astrophysics Data System (ADS)

    Boghaei, Davar M.; Gharagozlou, Mehrnaz

    2007-07-01

    A series of new ternary zinc(II) complexes [Zn(L 1-10)(phen)], where phen is 1,10-phenanthroline and H 2L 1-10 = tridentate Schiff base ligands derived from the condensation of amino acids (glycine, L-phenylalanine, L-valine, L-alanine, and L-leucine) and salicylaldehyde-5-sulfonates (sodium salicylaldehyde-5-sulfonate and sodium 3-methoxy-salicylaldehyde-5-sulfonate), have been synthesized. The complexes were characterized by elemental analysis, IR, UV-vis, 1H NMR, and 13C NMR spectra. The IR spectra of the complexes showed large differences between νas(COO) and νs(COO), Δ ν ( νas(COO) - νs(COO)) of 191-225 cm -1, indicating a monodentate coordination of the carboxylate group. Spectral data showed that in these ternary complexes the zinc atom is coordinated with the Schiff base ligand acts as a tridentate ONO moiety, coordinating to the metal through its phenolic oxygen, imine nitrogen, and carboxyl oxygen, and also with the neutral planar chelating ligand, 1,10-phenanthroline, coordinating through nitrogens.

  3. The effect of outdoor air and indoor human activity on mass concentrations of PM(10), PM(2.5), and PM(1) in a classroom.

    PubMed

    Branis, Martin; Rezácová, Pavla; Domasová, Markéta

    2005-10-01

    The 12-h mass concentration of PM(10), PM(2.5), and PM(1) was measured in a lecturing room by means of three co-located Harvard impactors. The filters were changed at 8 AM and at 8 PM to cover the periods of presence and absence of students. Concentrations were assessed by gravimetry. Ambient PM(10) data were available for corresponding 12-h intervals from the nearest state air-quality-monitoring network station. The data were pooled into four periods according to the presence and absence of students-Monday-Thursday day (workday daytime), Monday-Thursday night (workday night), Friday-Sunday day (weekend daytime), and Friday-Sunday night (weekend night). Average indoor workday daytime concentrations were 42.3, 21.9 and 13.7 microgm(-3), workday night were 20.9, 19.1 and 15.2 microgm(-3), weekend daytime were 21.9, 18.1 and 11.4 microgm(-3), and weekend night were 24.5, 21.3, and 15.6 microgm(-3) for PM(10), PM(2.5), and PM(1), respectively. The highest 12-h mean, median, and maximum (42.3, 43.0, and 76.2 microgm(-3), respectively) indoor concentrations were recorded on workdays during the daytime for PM(10). The statistically significant (r=0.68,P<0.0009) correlation between the number of students per hour per day and the indoor coarse fraction calculated as PM(10--2.5) during daytime on workdays indicates that the presence of people is an important source of coarse particles indoor. On workdays, the daytime PM(10) indoor/outdoor ratio was positively associated (r=0.93) with an increasing indoor coarse fraction (PM(10--2.5)), also indicating that an important portion of indoor PM(10) had its source inside the classroom. With the exception of the calculated coarse fraction (PM(10--2.5)), all of the measured indoor particulate matter fractions were significantly highly correlated with outdoor PM(10) and negatively correlated with wind velocity, showing that outdoor levels of particles influence their indoor concentrations.

  4. MAXIMA-1: A Measurement of the Cosmic Microwave Background Anisotropy on Angular Scales of 10' to 5 degrees

    DOE R&D Accomplishments Database

    Ade, P.; Balbi, A.; Bock, J.; Borrill, J.; Boscaleri, A.; de Bernardis, P.; Ferreira, P. G.; Hanany, S.; Hristov, V. V.; Jaffe, A. H.; Lange, A. E.; Lee, A. T.; Mauskopf, P. D.; Netterfield, C. B.; Oh, S.; Pascale, E.; Rabii, B.; Richards, P. L.; Smoot, G. F.; Stompor, R.; Winant,C. D.; Wu, J. H. P.

    2005-06-04

    We present a map and an angular power spectrum of the anisotropy of the cosmic microwave background (CMB) from the first flight of MAXIMA. MAXIMA is a balloon-borne experiment with an array of 16 bolometric photometers operated at 100 mK. MAXIMA observed a 124 deg{sup 2} region of the sky with 10' resolution at frequencies of 150, 240 and 410 GHz. The data were calibrated using in-flight measurements of the CMB dipole anisotropy. A map of the CMB anisotropy was produced from three 150 and one 240 GHz photometer without need for foreground subtractions.

  5. 5 CFR 1604.10 - Loans.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Loans. 1604.10 Section 1604.10 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD UNIFORMED SERVICES ACCOUNTS § 1604.10 Loans. A service member may be eligible for a TSP loan as described at 5 CFR part 1655, with the...

  6. 5 CFR 1604.10 - Loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Loans. 1604.10 Section 1604.10 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD UNIFORMED SERVICES ACCOUNTS § 1604.10 Loans. A service member may be eligible for a TSP loan as described at 5 CFR part 1655, with the...

  7. 5 CFR 1604.10 - Loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Loans. 1604.10 Section 1604.10 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD UNIFORMED SERVICES ACCOUNTS § 1604.10 Loans. A service member may be eligible for a TSP loan as described at 5 CFR part 1655, with the...

  8. MAXIMA-1: A Measurement of the Cosmic Microwave BackgroundAnisotropy on angular scales of 10' to 5 degrees

    SciTech Connect

    Ade, P.; Balbi, A.; Bock, J.; Borrill, J.; Boscaleri, A.; deBernardis, P.; Ferreira, P.G.; Hanany, S.; Hristov, V.V.; Jaffe, A.H.; Lange, A.E.; Lee, A.T.; Mauskopf, P.D.; Netterfield, C.B.; Oh, S.; Pascale, E.; Rabii, B.; Richards, P.L.; Smoot, G.F.; Stompor, R.; Winant,C.D.; Wu, J.H.P.

    2000-10-02

    We present a map and an angular power spectrum of the anisotropy of the cosmic microwave background (CMB) from the first flight of MAXIMA. MAXIMA is a balloon-borne experiment with an array of 16 bolometric photometers operated at 100 mK. MAXIMA observed a 124 deg region of the sky with 10' resolution at frequencies of 150, 240 and 410 GHz. The data were calibrated using in-flight measurements of the CMB dipole anisotropy. A map of the CMB anisotropy was produced from three 150 and one 240 GHz photometer without need for foreground subtractions. Analysis of this CMB map yields a power spectrum for the CMB anisotropy over the range 36 {le} {ell} {le} 785. The spectrum shows a peak with an amplitude of 78 {+-} 6 {mu}K at {ell} {approx_equal} 220 and an amplitude varying between {approx} 40 {mu}K and {approx} 50 {mu}K for 400 {approx}< {ell} {approx}< 785.

  9. Coupling of 3,8-Dibromo-1,10-Phenanthroline With 3,5-Diethynylheptyloxybenzene: A Suzuki/Miyaura Versus a Sonogashira Perspective

    NASA Technical Reports Server (NTRS)

    Yang, Jinhua; Oh, Woon Su; Elder, Ian A.; Leventis, Nicholas; Sotiriou-Leventis, Chariklia

    2003-01-01

    We report a new application of the Suzuki-Miyaura reaction whereas two bifunctional reactants, 3,8-dibromo-1,10-phenanthroline and 3,5-diethynylheptyloxylbenzene (9), yield 3,8-bis (3-ethynyl-5-heptyloxyphenylethynyl)-1,10-phenanthroline (2) efficiently (74% yield) without polymerization. This was achieved by reacting a stoichiometric amount of 9 and (Me3Si)2NLi to obtain quantitatively the monoacetylide anion of 9 (10). The latter was activated with B-methoxy-9-BBN and reacted in analogy to the alkynyl copper complex of a Sonogashira route. However, in the Sonogashira reaction, the alkynyl copper complex is present in small equilibrium concentrations and polymerization takes place even when reagents are mixed slowly. Actually the Sonogashira route gave no desired product 2, as the latter polymerizes easily via homo-coupling in the presence of air and Cu(I). Sonogashira coupling involves the palladium(0) catalyzed reaction of terminal alkynes.

  10. The High Arctic Magnetic High - The Geophysical Manifestation of a Large (1.36 x 10e6 km2) and Voluminous (5-10 x 10e6 km3) Igneous Province

    NASA Astrophysics Data System (ADS)

    Saltus, Richard; Oakey, Gordon; Miller, Elizabeth; Jackson, Ruth

    2013-04-01

    The High Arctic Magnetic High (HAMH) dominates the magnetic anomaly field of the Earth north of about 75°N; this magnetic domain consists of very high amplitude magnetic highs and lows with variable orientations. The HAMH is visible on satellite magnetic compilations (e.g., MF6) with anomaly amplitudes greater than 200 nT indicating it is a globally significant feature. The magnetic potential of this magnetic feature is a single large intensity high indicative of a large volume of magnetic material in the crust. The map area of this magnetic domain is roughly 1.36 x 10e6 km2. Geographically the HAMH lies within the Amerasian Basin adjacent to the Lomonosov Ridge, encompasses the region of the Alpha and Mendeleev Ridges, and extends beneath the northern portions of the Canada Basin. Ocean floor geomorphology, limited seismic and sonobouy data, sparse dredge samples, and dated samples from the perimeter of the Arctic Ocean are consistent with the interpretation of the HAMH as the geophysical manifestation of a Large Igneous Province. The designation "High Arctic Large Igneous Province (HALIP)" has been applied to portions of the Arctic perimeter based on geologic mapping and sampling. The designation "Alpha/Mendeleev Large Igneous Province (AMLIP)" has been applied to the offshore Alpha/Mendeleev region (e.g., Grantz et al., 2009) with boundaries defined, in large part, by magnetic anomaly patterns. We have constructed 2D and 3D models of the HAMH to investigate the structure and geometry of this significant crustal feature. We estimate the overall volume of magnetic material as between 5-10 x 10e6 km3. The area and volume of this feature are comparable with estimates for the Deccan Traps and the North Atlantic Igneous Province, but are significantly smaller than the Kerguellen or Ontong Java Plateaus (based on tables in Coffin and Eldholm, 1994). In detail we find significant correlation between shorter wavelength portions of this magnetic feature and the

  11. A σ(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).

    PubMed

    Banister, Samuel D; Manoli, Miral; Doddareddy, Munikumar Reddy; Hibbs, David E; Kassiou, Michael

    2012-10-01

    A library of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs) was synthesized and subjected to competition binding assays at σ(1) and σ(2) receptors, as well as off-target screening of representative members at 44 other common central nervous system (CNS) receptors, transporters, and ion channels. Excluding 3 low affinity analogs, 31 ligands demonstrated nanomolar K(i) values for either σ receptor subtype. Several selective σ(1) and σ(2) ligands were discovered, with selectivities of up to 29.6 times for σ(1) and 52.4 times for σ(2), as well as several high affinity, subtype non-selective ligands. The diversity of structures and σ(1) affinities of the ligands allowed the generation of a σ(1) receptor pharmacophore that will enable the rational design of increasingly selective and potent σ(1) ligands for probing σ(1) receptor function.

  12. Synthesis, crystal structure and vibrational spectroscopic analysis of tetrakis(5-amino-1-H-1,2,4-triazol-4-ium) decachlorodibismuthate(III):[C2H5N4]4Bi2Cl10

    NASA Astrophysics Data System (ADS)

    Aloui, Z.; Ferretti, V.; Abid, S.; Lefebvre, F.; Rzaigui, M.; Nasr, C. Ben

    2015-10-01

    Physico-chemical properties of a new organic bismuthate(III), [C2H5N4]4Bi2Cl10 are discussed on the basis of X-ray crystal structure investigation. This compound crystallizes in the monoclinic space group C2/c, with a = 16.3622(3), b = 12.7941(2), c = 14.8178(2) Å, β = 98.5660(10)°, V = 3067.35(8) Å3 and Z = 4. The crystal structure consists of discrete binuclear [Bi2Cl10]4- anions and 3-amino-1-H-1,2,4-triazolium cations. The crystal packing is governed by strong Nsbnd H⋯N and weak Nsbnd H⋯Cl hydrogen bonds and Π-Π stacking interactions to form three-dimensional network. The 13C CP-MAS NMR spectrum is in agreement with the X-ray structure. The infrared study confirms the presence of the organic cation [C2H5N4]+. The vibrational absorption bands were identified by infrared spectroscopy and DFT calculations allowed their attribution.

  13. 40 CFR Table C-4 to Subpart C of... - Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...% 10% 2 10% 2 10% 2 10% 2 Precision of PM2.5 or PM10-2.5 candidate method, CP, each site 10% 2 15% 2 15% 2 15% 2 Slope of regression relationship 1 ± 0.10 1 ± 0.05 1 ± 0.10 1 ± 0.10 1 ± 0.10 1 ±...

  14. 40 CFR Table C-4 to Subpart C of... - Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...% 10% 2 10% 2 10% 2 10% 2 Precision of PM2.5 or PM10-2.5 candidate method, CP, each site 10% 2 15% 2 15% 2 15% 2 Slope of regression relationship 1 ± 0.10 1 ± 0.05 1 ± 0.10 1 ± 0.10 1 ± 0.10 1 ±...

  15. Molecule 1,5-C10H6(SO2Cl)2 as prototype of conformational properties of naphthalene sulfonyl derivatives

    NASA Astrophysics Data System (ADS)

    Petrov, Vjacheslav M.; Giricheva, Nina I.; Ivanov, Sergey N.; Petrova, Valentina N.; Girichev, Georgiy V.

    2017-03-01

    Conformational composition of the vapor (T = 413(5) K) and the conformer structures of 1,5-naphthalenedisulfonylchloride (1,5-NaphDSC) have been studied by a combined gas-phase electron diffraction and mass spectrometry (GED/MS) method complemented by quantum chemical calculations. According to quantum chemical calculations at DFT/B3LYP/cc-pVTZ and MP2/cc-pVTZ theory levels, the molecule 1,5-NaphDSC possesses four conformers differing mutual orientation of the two SO2Cl groups. GED data clearly indicate that only two conformers, whose structures are characterized by deviation of two Ssbnd Cl bonds from perpendicular position relative to the plane of the naphthalene skeleton (syn-symmetry C2 and anti-symmetry Ci), are present in vapor at 413 K. The following geometrical parameters of these conformers were obtained from the experiment (Å and degrees; uncertainties are in parentheses): rh1(Csbnd H) = 1.098(9), rh1(Csbnd C) = 1.405(3), rh1(Csbnd S) = 1.781(4), rh1(Ssbnd O) = 1.426(3), rh1(Ssbnd Cl) = 2.056(4), ∠Csbnd CSsbnd C = 122.9(1), ∠CSsbnd Ssbnd Cl = 101.8(6); C9sbnd C1sbnd Ssbnd Cl = 71.2(12), C10sbnd C5sbnd Ssbnd Cl = 71.2(12)-syn conformer; C9sbnd C1sbnd Ssbnd Cl = 71.2(12), C10sbnd C5sbnd Ssbnd Cl = -71.2(12) -anti-conformer. The presence of C9Hn+ ions in the mass spectra of naphthalenesulfonyl chlorides, which are absent in the mass spectrum of naphthalene, may be attributed to the weakening of two Csbnd C bonds adjacent to the substituent of the naphthalene skeleton. This reflects in the geometric parameters of 1,5-NaphDSC. The barriers to internal rotation of sulfonyl chloride groups were calculated. It is shown that the low-energy syn- and anti-conformers are structurally rigid, in contrast to high-energy conformers with one or two Ssbnd Cl bonds, lying in the plane of the naphthalene skeleton. The dependence of C1sbnd C2, Csbnd S, Ssbnd Cl bond lengths from SO2Cl groups orientation relative to naphthalene skeleton is discussed in terms of NBO

  16. A Novel Cu-10Zn-1.5Ni-0.34Si Alloy with Excellent Mechanical Property Through Precipitation Hardening

    NASA Astrophysics Data System (ADS)

    Chen, Wei; Wang, Mingpu; Li, Zhou; Dong, Qiyi; Jia, Yanlin; Xiao, Zhu; Zhang, Rui; Yu, Hongchun

    2016-11-01

    A novel Cu-10Zn-1.5Ni-0.34Si alloy was designed to replace the expensive tin-phosphor bronze in this paper. The alloy had better comprehensive mechanical properties than traditional C5191 alloy. The aged Cu-10Zn-1.5Ni-0.34Si alloy had a hardness of 220 HV, electrical conductivity of 28.5% IACS, tensile strength of 650 MPa, yield strength of 575 MPa and elongation of 13%. Ni2Si precipitates formed during aging, and the crystal orientation relationship between matrix and precipitates was: (001)α//(001)δ, and [110]α//[100]δ. Ductile fracture surface with deep cavities was found in the alloy. Solid solution strengthening, deformation strengthening and precipitation strengthening were found to be core strengthening mechanisms in the alloy.

  17. 46 CFR 53.10-1 - General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false General. 53.10-1 Section 53.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Tests, Inspection, Stamping, and Reporting (Article 5) § 53.10-1 General. The tests, inspection, stamping, and reporting of...

  18. 46 CFR 53.10-1 - General.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false General. 53.10-1 Section 53.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Tests, Inspection, Stamping, and Reporting (Article 5) § 53.10-1 General. The tests, inspection, stamping, and reporting of...

  19. 46 CFR 53.10-1 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false General. 53.10-1 Section 53.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Tests, Inspection, Stamping, and Reporting (Article 5) § 53.10-1 General. The tests, inspection, stamping, and reporting of...

  20. 46 CFR 53.10-1 - General.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false General. 53.10-1 Section 53.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Tests, Inspection, Stamping, and Reporting (Article 5) § 53.10-1 General. The tests, inspection, stamping, and reporting of...

  1. 46 CFR 53.10-1 - General.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false General. 53.10-1 Section 53.10-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING HEATING BOILERS Tests, Inspection, Stamping, and Reporting (Article 5) § 53.10-1 General. The tests, inspection, stamping, and reporting of...

  2. Electron Capture by B^5+ from H2 At E < 1.0 keV/amu

    NASA Astrophysics Data System (ADS)

    Joseph, Dwayne C.; Saha, Bidhan C.

    2007-06-01

    The capture of electrons from molecular targets has considerable influence on the charge state balance of astrophysical as well as magnetically confined fusion plasmas. Molecular targets are in general more complicated than their atomic counterparts. A suitable method by freezing the molecular details of the targets is applied with a core potential [1] that represents the ionic core of the target. The molecular orbital method, including the electron translation factor [2], in the impact parameter formalism [3] is employed to evaluate the state selective cross sections. The motion of the nuclei is treated classically and that due to electron is considered quantum mechanically [4]. Details will be presented at the conference. [1] J. N. Bradsley, Case Stud. At. Phys. 4, 299 (1974). [2] M. Kimura and N. F. Lane, Adv. At. Mol. Opt. Phys. 26, 79 (1990). [3] B. C. Saha and A. Kumar, J. Mol. Struct. THEOCHEM, 487, 11 (1999). [4] A. Kumar and B. C. Saha, Phys. Rev. A 59, 1273 (1999).

  3. The Variation of Solar Fe 14 and Fe 10 Flux over 1.5 Solar Activity Cycles

    NASA Technical Reports Server (NTRS)

    Altrock, Richard C.

    1990-01-01

    A new source of data on the solar output, namely limb flux from the one- and two-million degree corona is presented. This parameter is derived from data obtained at the National Solar Observatory at Sacramento Peak with the 40 cm coronagraph of the John W. Evans Solar Facility and the Emission Line Coronal Photometer. The limb flux is defined to be the latitude-averaged intensity in millionths of the brightness of disk center from an annulus of width 1.1 minutes centered at a height of 0.15 solar constant above the limb of emission from lines at 6374A (Fe X) or 5303A (Fe XIV). Fe XIV data have been obtained since 1973 and Fe X since 1984. Examination of the Fe XIV data shows that there is ambiguity in the definition of the last two solar activity minima, which can affect the determination of cycle rise times and lengths. There is an indication that a constant minimum or basal corona may exist at solar minimum. Cycle 22 has had a much faster onset than Cycle 21 and has now overtaken Cycle 21. The rise characteristics of the two cycles were very similar up until Jul. to Aug. 1989, at which time a long-term maximum occurred in Fe X and Fe XIV, which could possibly be the solar maximum. Another maximum is developing at the current time. Cycle 21 was characterized in Fe XIV by at least 4 major thrusts or bursts of activity, each lasting on the order of a year and all having similar maximum limb fluxes which indicates that coronal energy output is sustained over periods in which the sunspot number declines significantly. Dramatic increases in the limb fluxes occur from minimum to maximum, ranging from factors of 14 to 21 in the two lines. Two different techniques to predict the epoch of solar maximum have been applied to the Fe XIV data, resulting in estimates of April 1989 (plus or minus 1 mo) and May 1990 (plus or minus 2 mos).

  4. NOTE: Computational dosimetry in embryos exposed to electromagnetic plane waves over the frequency range of 10 MHz-1.5 GHz

    NASA Astrophysics Data System (ADS)

    Kawai, Hiroki; Nagaoka, Tomoaki; Watanabe, Soichi; Saito, Kazuyuki; Takahashi, Masaharu; Ito, Koichi

    2010-01-01

    This paper presents calculated specific absorption rate (SAR) dosimetry in 4 and 8 week Japanese pregnant-woman models exposed to plane waves over the frequency range of 10 MHz-1.5 GHz. Two types of 2 mm spatial-resolution pregnant-woman models comprised a woman model, which is similar to the average-sized Japanese adult female in height and weight, with a cubic (4 week) embryo or spheroidal (8 week) one. The averaged SAR in the embryos exposed to vertically and horizontally polarized plane waves at four kinds of propagation directions are calculated from 10 MHz to 1.5 GHz. The results indicate that the maximum average SAR in the embryos exposed to plane waves is lower than 0.08 W kg-1 when the incident power density is at the reference level of ICNIRP guideline for general public environment.

  5. Molecular structure investigation of organic cocrystals of 1,10-phenanthroline-5,6-dione with aryloxyacetic acid: a combined experimental and theoretical study.

    PubMed

    Suresh Kumar, G S; Muthu Prabhu, A Antony; Bhuvanesh, N; Ronica, X A V; Kumaresan, S

    2014-11-11

    Two organic cocrystals namely, 1,10-phenanthroline-5,6-dione:2-naphthoxyacetic acid [(phendione)(2-naa)] (1) and 1,10-phenanthroline-5,6-dione:2-formylphenoxyacetic acid [(phendione)(2-fpaa)] (2) were synthesized and studied by single crystal XRD, FT-IR, NMR, thermogravimetric, and powder X-ray diffraction analysis. The molecular properties of cocrystals were studied using density functional theory (DFT), basis set B3LYP/6-31G(d,p). Both cocrystals are stabilized through intermolecular hydrogen bonding (OH⋯N). The total electron density and molecular electrostatic potential surfaces of the cocrystals were constructed by NBO analysis using B3LYP/6-31G(d,p) method to display the electrostatic potential (electron+nuclei) distribution. The energy gap between HOMO and LUMO was measured for both cocrystals.

  6. Molecular structure investigation of organic cocrystals of 1,10-phenanthroline-5,6-dione with aryloxyacetic acid: A combined experimental and theoretical study

    NASA Astrophysics Data System (ADS)

    Suresh Kumar, G. S.; Antony Muthu Prabhu, A.; Bhuvanesh, N.; Ronica, X. A. V.; Kumaresan, S.

    2014-11-01

    Two organic cocrystals namely, 1,10-phenanthroline-5,6-dione:2-naphthoxyacetic acid [(phendione)(2-naa)] (1) and 1,10-phenanthroline-5,6-dione:2-formylphenoxyacetic acid [(phendione)(2-fpaa)] (2) were synthesized and studied by single crystal XRD, FT-IR, NMR, thermogravimetric, and powder X-ray diffraction analysis. The molecular properties of cocrystals were studied using density functional theory (DFT), basis set B3LYP/6-31G(d,p). Both cocrystals are stabilized through intermolecular hydrogen bonding (Osbnd H⋯N). The total electron density and molecular electrostatic potential surfaces of the cocrystals were constructed by NBO analysis using B3LYP/6-31G(d,p) method to display the electrostatic potential (electron + nuclei) distribution. The energy gap between HOMO and LUMO was measured for both cocrystals.

  7. CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection.

    PubMed

    Zou, Qiang; Wu, Bing; Xue, Jia; Fan, Xiaoxu; Feng, Congcong; Geng, Shuang; Wang, Ming; Wang, Bin

    2014-01-01

    Although Treg-cell-mediated suppression during infection or autoimmunity has been described, functions of Treg cells during highly pathogenic avian influenza virus infection remain poorly characterized. Here we found that in Foxp3-GFP transgenic mice, CD8(+) Foxp3(+) Treg cells, but not CD4(+) Foxp3(+) Treg cells, were remarkably induced during H5N1 infection. In addition to expressing CD25, the CD8(+) Foxp3(+) Treg cells showed a high level of GITR and produced IL-10. In an adoptive transfer model, CD8(+) Treg cells suppressed CD8(+) T-cell responses and promoted H5N1 virus infection, resulting in enhanced mortality and increased virus load in the lung. Furthermore, in vitro neutralization of IL-10 and studies with IL-10R-deficient mice in vitro and in vivo demonstrated an important role for IL-10 production in the capacity of CD8(+) Treg cells to inhibit CD8(+) T-cell responses. Our findings identify a previously unrecognized role of CD8(+) Treg cells in the negative regulation of CD8(+) T-cell responses and suggest that modulation of CD8(+) Treg cells may be a therapeutic strategy to control H5N1 viral infection.

  8. 34 CFR 5.10 - Public reading room.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Public reading room. 5.10 Section 5.10 Education Office... Available to the Public § 5.10 Public reading room. (a) General. Pursuant to 5 U.S.C. 552(a)(2), the Department maintains a public reading room containing agency records that the FOIA requires to be...

  9. 34 CFR 5.10 - Public reading room.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Public reading room. 5.10 Section 5.10 Education Office... Available to the Public § 5.10 Public reading room. (a) General. Pursuant to 5 U.S.C. 552(a)(2), the Department maintains a public reading room containing agency records that the FOIA requires to be...

  10. 34 CFR 5.10 - Public reading room.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Public reading room. 5.10 Section 5.10 Education Office... Available to the Public § 5.10 Public reading room. (a) General. Pursuant to 5 U.S.C. 552(a)(2), the Department maintains a public reading room containing agency records that the FOIA requires to be...

  11. 34 CFR 5.10 - Public reading room.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Public reading room. 5.10 Section 5.10 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC Agency Records Available to the Public § 5.10 Public reading room. (a) General. Pursuant to 5 U.S.C. 552(a)(2),...

  12. Operation of NIM5 fountain with 1.5x10-15 uncertainty and design of new NIM6 in NIM

    NASA Astrophysics Data System (ADS)

    Fang, F.; Liu, N.; Liu, K.; Chen, W.; Suo, R.; Li, Tianchu

    2016-06-01

    The cesium fountain primary frequency standard NIM5 started to operate since 2008 and started to report to BIPM since 2014. The major constrains of NIM5 is a relatively large background signal at the detection and microwave leakages due to the Ramsey cavity. A new fountain clock NIM6 is under construction. Besides some improvements on the vacuum system, a new Ramsey cavity and a microwave synthesizer are made to reduce the Type B uncertainty. Another feature of NIM6 is collecting atoms from a MOT loading optical molasses to get more atoms with a more uniform density distribution. With a new frequency synthesizer based on cryogenic sapphire oscillator (CSO), NIM6 is aiming to reach the quantum projection noise, thus leading to a reduced Type A uncertainty compared with NIM5.

  13. Main components and human health risks assessment of PM10, PM2.5, and PM1 in two areas influenced by cement plants

    NASA Astrophysics Data System (ADS)

    Sánchez-Soberón, Francisco; Rovira, Joaquim; Mari, Montse; Sierra, Jordi; Nadal, Martí; Domingo, José L.; Schuhmacher, Marta

    2015-11-01

    Particulate matter (PM) is widely recorded as a source of diseases, being more harmful those particles with smaller size. PM is released to the environment as a consequence of different activities, being one of them cement production. The objective of this pilot study was to characterize PM of different sizes around cement facilities to have a preliminary approach of their origin, and evaluate their potential health risks. For that purpose, three fractions of PM (10, 2.5, and 1) were collected in the nearby area of two cement plants with different backgrounds (urban and rural) in different seasons. Subsequently, main components, outdoor and indoor concentrations, exposure, and human health risks were assessed. Greatest levels of PM1, organic matter, and metals were found in urban location, especially in winter. Consequently, environmental exposure and human health risks registered their highest values in the urban plant during wintertime. Exposure was higher for indoor activities, expressing some metals their peak values in the PM1 fraction. Non-carcinogenic risks were below the safety threshold (HQ < 1). Carcinogenic risks for most of the metals were below the limit of 10-5, except for Cr (VI), which exceeded it in both locations, but being in the range considered as assumable (10-6-10-4).

  14. Synthesis and crystal structure of copper complex of 7,16-bis(2-hydroxy-5-methyl-3-nitrobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

    NASA Astrophysics Data System (ADS)

    Ma, Shu-lan; Zhu, Wen-xiang

    2002-12-01

    A lariat crown ether compound 7,16-bis(2-hydroxy-5-methylbenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane has been prepared via one-pot Mannich reaction. A copper(II) complex with the ligand 7,16-bis(2-hydroxy-5-methyl-3-nitrobenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane was unexpectedly synthesized and characterized by elemental analysis, IR and UV spectra. The crystal structure of the complex has been determined by X-ray diffraction. Both crystal structure analysis and spectroscopy study indicated that the side-arm phenols of lariat crown ether are nitrated while complexing with Cu(NO 3) 2. Structure shows that the copper(II) ion is coordinated to two nitrogen and four oxygen atoms, two from the crown ether and other two from the deprotonated phenolate groups. The coordination polyhedron is a distorted octahedron.

  15. Characterization of PAHs and metals in indoor/outdoor PM10/PM2.5/PM1 in a retirement home and a school dormitory.

    PubMed

    Hassanvand, Mohammad Sadegh; Naddafi, Kazem; Faridi, Sasan; Nabizadeh, Ramin; Sowlat, Mohammad Hossein; Momeniha, Fatemeh; Gholampour, Akbar; Arhami, Mohammad; Kashani, Homa; Zare, Ahad; Niazi, Sadegh; Rastkari, Noushin; Nazmara, Shahrokh; Ghani, Maryam; Yunesian, Masud

    2015-09-15

    In the present work, we investigated the characteristics of polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s in indoor/outdoor PM10, PM2.5, and PM1 in a retirement home and a school dormitory in Tehran from May 2012 to May 2013. The results indicated that the annual levels of indoor and outdoor PM10 and PM2.5 were much higher than the guidelines issued by the World Health Organization (WHO). The most abundant detected metal(loid)s in PM were Si, Fe, Zn, Al, and Pb. We found higher percentages of metal(loid)s in smaller size fractions of PM. Additionally, the results showed that the total PAHs (ƩPAHs) bound to PM were predominantly (83-88%) found in PM2.5, which can penetrate deep into the alveolar regions of the lungs. In general, carcinogenic PAHs accounted for 40-47% of the total PAHs concentrations; furthermore, the smaller the particle size, the higher the percentage of carcinogenic PAHs. The percentages of trace metal(loid)s and carcinogenic PAHs in PM2.5 mass were almost twice as high as those in PM10. This can most likely be responsible for the fact that PM2.5 can cause more adverse health effects than PM10 can. The average BaP-equivalent carcinogenic (BaP-TEQ) levels both indoors and outdoors considerably exceeded the maximum permissible risk level of 1 ng/m(3) of BaP. The enrichment factors and diagnostic ratios indicated that combustion-related anthropogenic sources, such as gasoline- and diesel-fueled vehicles as well as natural gas combustion, were the major sources of PAHs and trace metal(loid)s bound to PM.

  16. Benzyl 5-hy­droxy-4-oxapenta­cyclo­[5.4.1.02,6.03,10.08,11]dodecane-3-carboxyl­ate

    PubMed Central

    Karpoormath, Rajshekhar; Naicker, Tricia; Govender, Thavendran; Kruger, Hendrik G.; Maguire, Glenn E. M.

    2011-01-01

    The title compound, C19H18O4, exhibits a long C—C bond [1.575 (2) Å] in the cage structure. In the crystal, pairs of O—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. C—H⋯O inter­actions also occur. PMID:21754154

  17. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  18. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  19. 10 CFR 60.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 60.5 Section 60.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.5 Interpretations. Except as specifically authorized by the Commission, in writing,...

  20. 10 CFR 61.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 61.5 Section 61.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  1. 10 CFR 61.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Interpretations. 61.5 Section 61.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  2. 10 CFR 60.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Interpretations. 60.5 Section 60.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.5 Interpretations. Except as specifically authorized by the Commission, in writing,...

  3. 10 CFR 60.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 60.5 Section 60.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.5 Interpretations. Except as specifically authorized by the Commission, in writing,...

  4. 10 CFR 61.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Interpretations. 61.5 Section 61.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  5. 10 CFR 61.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Interpretations. 61.5 Section 61.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  6. 10 CFR 61.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 61.5 Section 61.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE General Provisions § 61.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  7. 10 CFR 60.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Interpretations. 60.5 Section 60.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.5 Interpretations. Except as specifically authorized by the Commission, in writing,...

  8. 10 CFR 60.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Interpretations. 60.5 Section 60.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN GEOLOGIC REPOSITORIES General Provisions § 60.5 Interpretations. Except as specifically authorized by the Commission, in writing,...

  9. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  10. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  11. 10 CFR 830.5 - Enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Enforcement. 830.5 Section 830.5 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.5 Enforcement. The requirements in this part are DOE Nuclear Safety Requirements and are subject to enforcement by all appropriate means, including the imposition...

  12. 10 CFR 63.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 63.5 Section 63.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.5 Interpretations. Except as specifically authorized by...

  13. 10 CFR 63.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Interpretations. 63.5 Section 63.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.5 Interpretations. Except as specifically authorized by...

  14. 10 CFR 63.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Interpretations. 63.5 Section 63.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.5 Interpretations. Except as specifically authorized by...

  15. 10 CFR 63.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Interpretations. 63.5 Section 63.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.5 Interpretations. Except as specifically authorized by...

  16. 10 CFR 63.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 63.5 Section 63.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA General Provisions § 63.5 Interpretations. Except as specifically authorized by...

  17. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer,...

  18. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer,...

  19. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer,...

  20. 10 CFR 824.5 - Investigations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Investigations. 824.5 Section 824.5 Energy DEPARTMENT OF... VIOLATIONS § 824.5 Investigations. The Director may conduct investigations and inspections relating to the... investigation or inspection, including signing, issuing and serving subpoenas....

  1. 10 CFR 824.5 - Investigations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Investigations. 824.5 Section 824.5 Energy DEPARTMENT OF... VIOLATIONS § 824.5 Investigations. The Director may conduct investigations and inspections relating to the... investigation or inspection, including signing, issuing and serving subpoenas....

  2. 10 CFR 824.5 - Investigations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Investigations. 824.5 Section 824.5 Energy DEPARTMENT OF... VIOLATIONS § 824.5 Investigations. The Director may conduct investigations and inspections relating to the... investigation or inspection, including signing, issuing and serving subpoenas....

  3. 10 CFR 824.5 - Investigations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Investigations. 824.5 Section 824.5 Energy DEPARTMENT OF... VIOLATIONS § 824.5 Investigations. The Director may conduct investigations and inspections relating to the... investigation or inspection, including signing, issuing and serving subpoenas....

  4. 10 CFR 820.5 - Service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Service. 820.5 Section 820.5 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.5 Service. (a) General rule. Any document filed with the Docketing Clerk must be served on the addressee of the document and shall not be...

  5. 10 CFR 95.5 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Definitions. 95.5 Section 95.5 Energy NUCLEAR REGULATORY... RESTRICTED DATA General Provisions § 95.5 Definitions. Access authorization means an administrative... the National Industrial Security Program. Combination lock means a three position,...

  6. 10 CFR 95.5 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Definitions. 95.5 Section 95.5 Energy NUCLEAR REGULATORY... RESTRICTED DATA General Provisions § 95.5 Definitions. Access authorization means an administrative... three position, manipulation resistant, dial type lock bearing an Underwriters' Laboratories,...

  7. 10 CFR 95.5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Definitions. 95.5 Section 95.5 Energy NUCLEAR REGULATORY... RESTRICTED DATA General Provisions § 95.5 Definitions. Access authorization means an administrative... three position, manipulation resistant, dial type lock bearing an Underwriters' Laboratories,...

  8. 10 CFR 95.5 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Definitions. 95.5 Section 95.5 Energy NUCLEAR REGULATORY... RESTRICTED DATA General Provisions § 95.5 Definitions. Access authorization means an administrative... three position, manipulation resistant, dial type lock bearing an Underwriters' Laboratories,...

  9. 10 CFR 95.5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Definitions. 95.5 Section 95.5 Energy NUCLEAR REGULATORY... RESTRICTED DATA General Provisions § 95.5 Definitions. Access authorization means an administrative... three position, manipulation resistant, dial type lock bearing an Underwriters' Laboratories,...

  10. 10 CFR 850.5 - Dispute resolution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Dispute resolution. 850.5 Section 850.5 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.5 Dispute resolution. (a) Subject to paragraphs (b) and (c) of this section, any worker who is adversely affected by...

  11. 10 CFR 850.5 - Dispute resolution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Dispute resolution. 850.5 Section 850.5 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.5 Dispute resolution. (a) Subject to paragraphs (b) and (c) of this section, any worker who is adversely affected by...

  12. 10 CFR 850.5 - Dispute resolution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Dispute resolution. 850.5 Section 850.5 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.5 Dispute resolution. (a) Subject to paragraphs (b) and (c) of this section, any worker who is adversely affected by...

  13. 10 CFR 850.5 - Dispute resolution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Dispute resolution. 850.5 Section 850.5 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.5 Dispute resolution. (a) Subject to paragraphs (b) and (c) of this section, any worker who is adversely affected by...

  14. 10 CFR 850.5 - Dispute resolution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Dispute resolution. 850.5 Section 850.5 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM General Provisions § 850.5 Dispute resolution. (a) Subject to paragraphs (b) and (c) of this section, any worker who is adversely affected by...

  15. 10 CFR 820.5 - Service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Service. 820.5 Section 820.5 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR DOE NUCLEAR ACTIVITIES General § 820.5 Service. (a) General rule. Any document filed with the Docketing Clerk must be served on the addressee of the document and shall not be...

  16. 10 CFR 830.5 - Enforcement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Enforcement. 830.5 Section 830.5 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.5 Enforcement. The requirements in this part are DOE Nuclear Safety Requirements and are subject to enforcement by all appropriate means, including the imposition...

  17. 10 CFR 830.5 - Enforcement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Enforcement. 830.5 Section 830.5 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.5 Enforcement. The requirements in this part are DOE Nuclear Safety Requirements and are subject to enforcement by all appropriate means, including the imposition...

  18. 10 CFR 830.5 - Enforcement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Enforcement. 830.5 Section 830.5 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.5 Enforcement. The requirements in this part are DOE Nuclear Safety Requirements and are subject to enforcement by all appropriate means, including the imposition...

  19. 10 CFR 830.5 - Enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Enforcement. 830.5 Section 830.5 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT § 830.5 Enforcement. The requirements in this part are DOE Nuclear Safety Requirements and are subject to enforcement by all appropriate means, including the imposition...

  20. 10 CFR 51.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 51.5 Section 51.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.5 Interpretations. Except as specifically authorized by the Commission in...

  1. 10 CFR 51.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Interpretations. 51.5 Section 51.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS § 51.5 Interpretations. Except as specifically authorized by the Commission in...

  2. 10 CFR 75.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 75.5 Section 75.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General Provisions § 75.5 Interpretations. Except as authorized specifically by the Commission in writing,...

  3. 10 CFR 75.5 - Interpretations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Interpretations. 75.5 Section 75.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General Provisions § 75.5 Interpretations. Except as authorized specifically by the Commission in writing,...

  4. 10 CFR 75.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 75.5 Section 75.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General Provisions § 75.5 Interpretations. Except as authorized specifically by the Commission in writing,...

  5. 10 CFR 75.5 - Interpretations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Interpretations. 75.5 Section 75.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General Provisions § 75.5 Interpretations. Except as authorized specifically by the Commission in writing,...

  6. 10 CFR 75.5 - Interpretations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Interpretations. 75.5 Section 75.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT General Provisions § 75.5 Interpretations. Except as authorized specifically by the Commission in writing,...

  7. 10 CFR 810.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Interpretations. 810.5 Section 810.5 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.5 Interpretations. A person may request the advice of the Director, Nuclear Transfer and Supplier Policy Division (NN-43), on whether a...

  8. 10 CFR 810.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Interpretations. 810.5 Section 810.5 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.5 Interpretations. A person may request the advice of the Director, Nuclear Transfer and Supplier Policy Division (NN-43), on whether a...

  9. 10 CFR 420.5 - Reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Reports. 420.5 Section 420.5 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM General Provisions for State Energy Program Financial Assistance § 420.5 Reports. (a) Each State receiving financial assistance under this part shall submit to...

  10. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer,...

  11. 10 CFR 960.5 - Preclosure guidelines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Preclosure guidelines. 960.5 Section 960.5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5 Preclosure guidelines. The guidelines in this subpart specify...

  12. 10 CFR 960.5 - Preclosure guidelines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Preclosure guidelines. 960.5 Section 960.5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5 Preclosure guidelines. The guidelines in this subpart specify...

  13. 10 CFR 960.5 - Preclosure guidelines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Preclosure guidelines. 960.5 Section 960.5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5 Preclosure guidelines. The guidelines in this subpart specify...

  14. 10 CFR 960.5 - Preclosure guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preclosure guidelines. 960.5 Section 960.5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5 Preclosure guidelines. The guidelines in this subpart specify...

  15. 10 CFR 960.5 - Preclosure guidelines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Preclosure guidelines. 960.5 Section 960.5 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines § 960.5 Preclosure guidelines. The guidelines in this subpart specify...

  16. 10 CFR 1045.5 - Sanctions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Sanctions. 1045.5 Section 1045.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.5 Sanctions. (a) Knowing,...

  17. 10 CFR 1045.5 - Sanctions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Sanctions. 1045.5 Section 1045.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.5 Sanctions. (a) Knowing,...

  18. 10 CFR 1045.5 - Sanctions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Sanctions. 1045.5 Section 1045.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.5 Sanctions. (a) Knowing,...

  19. 10 CFR 1045.5 - Sanctions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Sanctions. 1045.5 Section 1045.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.5 Sanctions. (a) Knowing,...

  20. 10 CFR 1045.5 - Sanctions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Sanctions. 1045.5 Section 1045.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NUCLEAR CLASSIFICATION AND DECLASSIFICATION Program Management of the Restricted Data and Formerly Restricted Data Classification System § 1045.5 Sanctions. (a) Knowing,...

  1. 10 CFR 961.5 - Federal agencies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Federal agencies. 961.5 Section 961.5 Energy DEPARTMENT OF ENERGY STANDARD CONTRACT FOR DISPOSAL OF SPENT NUCLEAR FUEL AND/OR HIGH-LEVEL RADIOACTIVE WASTE General § 961.5 Federal agencies. Federal agencies or departments requiring DOE's disposal services for SNF...

  2. 10 CFR 725.5 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Communications. 725.5 Section 725.5 Energy DEPARTMENT OF ENERGY PERMITS FOR ACCESS TO RESTRICTED DATA General Provisions § 725.5 Communications. All communications concerning this part should be addressed to the Chief Health, Safety and Security Officer,...

  3. 10 CFR 74.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 74.5 Section 74.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL General Provisions § 74.5 Interpretations. Except as specifically authorized by the Commission in writing,...

  4. 10 CFR 1048.5 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Violations. 1048.5 Section 1048.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) TRESPASSING ON STRATEGIC PETROLEUM RESERVE FACILITIES AND OTHER PROPERTY § 1048.5 Violations. Willful unauthorized entry, or willful unauthorized introduction of weapons...

  5. 10 CFR 1048.5 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Violations. 1048.5 Section 1048.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) TRESPASSING ON STRATEGIC PETROLEUM RESERVE FACILITIES AND OTHER PROPERTY § 1048.5 Violations. Willful unauthorized entry, or willful unauthorized introduction of weapons...

  6. 10 CFR 861.5 - Penalties.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Penalties. 861.5 Section 861.5 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.5 Penalties. Any person doing any act forbidden or failing to do any act required by the Nevada Test Site Traffic Regulations shall, upon conviction, be...

  7. 10 CFR 861.5 - Penalties.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Penalties. 861.5 Section 861.5 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.5 Penalties. Any person doing any act forbidden or failing to do any act required by the Nevada Test Site Traffic Regulations shall, upon conviction, be...

  8. 10 CFR 861.5 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Penalties. 861.5 Section 861.5 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.5 Penalties. Any person doing any act forbidden or failing to do any act required by the Nevada Test Site Traffic Regulations shall, upon conviction, be...

  9. 10 CFR 861.5 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Penalties. 861.5 Section 861.5 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.5 Penalties. Any person doing any act forbidden or failing to do any act required by the Nevada Test Site Traffic Regulations shall, upon conviction, be...

  10. 10 CFR 861.5 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Penalties. 861.5 Section 861.5 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.5 Penalties. Any person doing any act forbidden or failing to do any act required by the Nevada Test Site Traffic Regulations shall, upon conviction, be...

  11. Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation.

    PubMed

    Ding, Jingjin; Wang, Xiaoyan; Li, De-Feng; Hu, Yonglin; Zhang, Ying; Wang, Da-Cheng

    2010-09-03

    Programmed cell death 10 (PDCD10) is a novel adaptor protein involved in human cerebral cavernous malformation, a common vascular lesion mostly occurring in the central nervous system. By interacting with different signal proteins, PDCD10 could regulate various physiological processes in the cell. The crystal structure of human PDCD10 complexed with inositol-(1,3,4,5)-tetrakisphosphate has been determined at 2.3A resolution. The structure reveals an integrated dimer via a unique assembly that has never been observed before. Each PDCD10 monomer contains two independent domains: an N-terminal domain with a new fold involved in the tight dimer assembly and a C-terminal four-helix bundle domain that closely resembles the focal adhesion targeting domain of focal adhesion kinase. An eight-residue flexible linker connects the two domains, potentially conferring mobility onto the C-terminal domain, resulting in the conformational variability of PDCD10. A variable basic cleft on the top of the dimer interface binds to phosphatidylinositide and regulates the intracellular localization of PDCD10. Two potential sites, respectively located on the two domains, are critical for recruiting different binding partners, such as germinal center kinase III proteins and the focal adhesion protein paxillin.

  12. Solvent induced synthesis, structure and properties of coordination polymers based on 5-hydroxyisophthalic acid as linker and 1,10-phenanthroline as auxiliary ligand

    SciTech Connect

    Kariem, Mukaddus; Yawer, Mohd; Sheikh, Haq Nawaz

    2015-11-15

    Three new coordination polymers [Mn(hip)(phen) (H{sub 2}O)]{sub n} (1), [Co(hip)(phen) (H{sub 2}O)]{sub n} (2), and [Cd(hip) (phen) (H{sub 2}O)]{sub n} (3) (H{sub 2}hip=5-hydroxyisophthalic acid; phen=1,10-phenanthroline) have been synthesized by solvo-hydrothermal method using diethyl formamide-water (DEF-H{sub 2}O) as solvent system. Single-crystal X-ray diffraction analysis reveals that all three coordination polymers 1, 2 and 3 crystallize in monoclinic space group P2/n. Metal ions are inter-connected by hydroxyisophthalate anions forming zig-zag 1D chain. 1D chains are further inter-connected by hydrogen bonding and π–π stacking interactions leading to 3D supramolecular architecture. Hydrogen-bonding and π–π stacking provide thermal stability to polymers. Compounds 1 and 2 are paramagnetic at room temperature and variable temperature magnetic moment measurements revealed weak ferromagnetic interactions between metal ions at low temperature. Compound 3 exhibits excellent photoluminescence with large Stokes shift. - Graphical abstract: 1D helical chains of coordination polymers were synthesized by solvo-hydrothermal reaction of 5-hydroxyisopthalic acid and 1,10-phenanthroline with MnCl{sub 2}·4H{sub 2}O / CoCl{sub 2}·6H{sub 2}O / Cd(NO{sub 3}){sub 2}·6H{sub 2}O. - Highlights: • Solvent induced synthesis of three coordination polymers with 1D zig-zag structure. • Crystal structures of coordination polymers are reported and discussed. • 1,10-Phenanthroline influences magnetic and luminescent properties of polymers. • Coordination polymer of Cd is luminescent exhibiting large Stokes shift.

  13. Water soluble organic carbon in aerosols (PM1, PM2.5, PM10) and various precipitation forms (rain, snow, mixed) over the southern Baltic Sea station.

    PubMed

    Witkowska, Agnieszka; Lewandowska, Anita U

    2016-12-15

    In the urbanized coastal zone of the Southern Baltic, complex measurements of water soluble organic carbon (WSOC) were conducted between 2012 and 2015, involving atmospheric precipitation in its various forms (rain, snow, mixed) and PM1, PM2.5 and PM10 aerosols. WSOC constituted about 60% of the organic carbon mass in aerosols of various sizes. The average concentration of WSOC was equal to 2.6μg∙m(-3) in PM1, 3.6μg∙m(-3) in PM2.5 and 4.4μg∙m(-3) in PM10. The lowest concentration of WSOC was noted in summer as a result of effective removal of this compound with rainfall. The highest WSOC concentrations in PM2.5 and PM10 aerosols were measured in spring, which should be associated with developing vegetation on land and in the sea. On the other hand, the highest WSOC concentrations in PM1 occurred in winter at low air temperatures and greatest atmospheric stability, when there were increased carbon emissions from fuel combustion in the communal-utility sector and from transportation. WSOC concentrations in precipitation were determined by its form. Mixed precipitation turned out to be the richest in soluble organic carbon (5.1mg·dm(-3)), while snow contained the least WSOC (1.7mg·dm(-3)). Snow and rain cleaned carbon compounds from the atmosphere more effectively when precipitation lasted longer than 24h, while in the case of mixed precipitation WSOC was removed most effectively within the first 24h.

  14. Crystal structure of 16-ferrocenylmethyl-3β-hydroxy­estra-1,3,5(10)-trien-17-one: a potential chemotherapeutic drug

    PubMed Central

    Carmona-Negrón, José A.; Flores-Rivera, Mariola M.; Díaz-Reyes, Zaibeth; Moore, Curtis E.; Rheigold, Arnold L.; Meléndez, Enrique

    2016-01-01

    A new ferrocene complex, 16-ferrocenylmethyl-3β-hy­droxy­estra-1,3,5(10)-trien-17-one dimethyl sulfoxide monosolvate, [Fe(C5H5)(C24H27O2)]·C2H6OS, has been synthesized and structurally characterized by single-crystal X-ray diffraction techniques. The mol­ecule crystallizes in the space group P21 with one mol­ecule of dimethyl sulfoxide. A hydrogen bond links the phenol group and the dimethyl sulfoxide O atom, with an O⋯O distance of 2.655 (5) Å. The ferrocene group is positioned in the β face of the estrone moiety, with an O—C—C—C torsion angle of 44.1 (5)°, and the carbonyl bond length of the hormone moiety is 1.216 (5) Å, typical of a C=O double bond. The average Fe—C bond length of the substituted Cp ring [Fe—C(Cp*)] is similar to that of the unsubstituted one [Fe—C(Cp)], i.e. 2.048 (3) versus 2.040 (12) Å. The structure of the complex is compared with those of estrone and eth­oxy­methyl­estrone. PMID:27308062

  15. 34 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Parents and guardians. 5b.10 Section 5b.10 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or...

  16. 34 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Parents and guardians. 5b.10 Section 5b.10 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or...

  17. 34 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Parents and guardians. 5b.10 Section 5b.10 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or...

  18. 34 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Parents and guardians. 5b.10 Section 5b.10 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or...

  19. 34 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Parents and guardians. 5b.10 Section 5b.10 Education Office of the Secretary, Department of Education PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or...

  20. Crystal structure of (1S,2R,6R,7R,8S,12S)-4,10,17-triphenyl-15-thia-4,10-diaza-penta-cyclo[5.5.5.0(1,16).0(2,6).0(8,12)]hepta-deca-13,16-diene-3,5,9,11-tetrone p-xylene hemisolvate.

    PubMed

    Noland, Wayland E; Kroll, Neil J; Huisenga, Matthew P; Yue, Ruixian A; Lang, Simon B; Klein, Nathan D; Tritch, Kenneth J

    2014-12-01

    The title tetrone compound, C32H22N2O4S· 0.5C8H10, is the major product (50% yield) of an attempted Diels-Alder reaction of 2-(α-styr-yl)thio-phene with N-phenyl-male-imide (2 equivalents) in toluene. Recrystallization of the resulting powder from p-xylene gave the title hemisolvate; the p-xylene mol-ecule is located about an inversion center. In the crystal, the primary tetrone contacts are between a carbonyl O atom and the four flagpole H atoms of the bi-cyclo-[2.2.2]octene core, forming chains along [001].

  1. 45 CFR 5b.10 - Parents and guardians.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Parents and guardians. 5b.10 Section 5b.10 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.10 Parents and guardians. For the purpose of this part, a parent or guardian of any minor or the legal guardian or any individual who has...

  2. Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer

    PubMed Central

    Cao, Qing-Hua; Liu, Fang; Yang, Zu-Li; Fu, Xin-Hui; Yang, Zi-Huan; Liu, Quentin; Wang, Lei; Wan, Xiang-Bo; Fan, Xin-Juan

    2016-01-01

    Autophagy-related (ATG) genes contributed to tumorigenesis and cancer progression. This study aims to investigate the expression of ATG proteins and their clinicopathological significance in gastric cancer. Nine well-known ATG proteins, (ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12 and LC3B) and p62/SQSTM1, which represented key regulators that participated in whole autophagosomes stepwise processes, were detected in a large cohort of 352 primary gastric cancer patients. Among these 352 patients, 117 cases were randomly assigned to the training set to detect the clinicopathological value of ATG proteins, and another 235 patients were used as the testing set for further validation. Except for Beclin 1, ATG9 and ATG10, another six ATG proteins and p62/SQSTM1 were closely correlated with histological types for gastric cancer. Moreover, low expression of ULK1, Beclin 1 and ATG10 were associated with lymph node metastasis. In addition, down-regulation of ULK1, Beclin 1, ATG7 and ATG10, up-regulation of ATG12 correlated with advanced TNM stage. Importantly, multivariate cox analysis identified ULK1, Beclin 1, ATG3 and ATG10 as favorable independent prognostic factors for overall survival. Combination analysis of ULK1, Beclin 1, ATG3, ATG10 revealed the improved prognostic accuracy for gastric cancer. Our study showed that ATG proteins might serve as novel prognostic biomarkers in gastric cancer, and supply a new valuable insight into cancer treatment targeting autophagy for patients. PMID:27725863

  3. Final Jurisdictional Environmental Planning Technical Report. Peacekeeper in Minuteman Silos, 90th Strategic Missile Wing, F. E. Warren Air Force Base. Volume 1. Section 1.0 through 5.0

    DTIC Science & Technology

    1984-01-01

    VARIOUS FREQUENCIES AND STORM DURATIONS - CHEYENNE, WYOMING Storm Recurrence Interval Duration 2-Year 5-Year 10-Year 25-Year 50-Year 100-Year 5 Min...hour storm inflows for 2 and 10-year recurrence intervals (derived from 3-hour rainfall patterns used by engineers in the Denver-Cheyenne region for...County, 39 in Cheyenne and 1 in Pine Bluffs. A full range of dental and orthodontic services is available in the county. 3.10.2.2 Projected Baseline

  4. Effect of the current annealing (without and with tensile stress) on the soft magnetic behaviour of Fe73.5-x(Co0.5Ni0.5)xSi13.5B9Nb3Cu1 alloy ribbons (x = 2.5, 5 and 10).

    PubMed

    Iturriza, N; Nazmunnahar, M; Dominguez, L; González, J; del Val, J J

    2012-06-01

    Experimental data on microstructural (crystalline volume fraction, grain size) and magnetic (coercive field) properties in amorphous and nanocrystalline Fe73.5-x(Co0.5Ni0.5)xSi13.5B9Nb3Cu1 alloy ribbons (x = 2.5, 5 and 10) are presented. Nanocrystalline structure was developed by annealing the precursor amorphous ribbons by current annealing (CA) and stress-current-annealing (SA). Microstructural analysis of the treated ribbons using X-ray Diffraction showed a high content of amorphous phase in the bulk. In addition, substantial changes in the crystalline state such as grain size of the samples annealed at different conditions were observed. The alloy composition also affects greatly the grain size,: increasing the (Co,Ni) content leads to higher values of the average grain size. The evolutions of the coercive field with the two kinds of thermal treatment were analysed, allowing us to conclude that the addition of (Co,Ni) tends to reduce the magnetic softness character of the original material, while the treated SA samples show higher coercivities higher than those treated without by CA.

  5. Conformational properties of 1-cyano-1-silacyclohexane, C5H10SiHCN: Gas electron diffraction, low-temperature NMR and quantum chemical calculations

    NASA Astrophysics Data System (ADS)

    Belyakov, Alexander V.; Sigolaev, Yrii F.; Shlykov, Sergey A.; Wallevik, Sunna Ó.; Jonsdottir, Nanna R.; Jonsdottir, Sigridur; Kvaran, Ágúst; Bjornsson, Ragnar; Arnason, Ingvar

    2017-03-01

    The conformational preference of the cyano group of the 1-cyano-1-silacyclohexane was studied experimentally by means of gas electron diffraction (GED) and dynamic nuclear magnetic resonance (DNMR) as well as by quantum chemical (QC) calculations applying high-level coupled cluster methods as well as DFT methods. According to the GED experiment, the compound exists in the gas-phase as a mixture of two conformers possessing the chair conformation of the six-membered ring and Cs symmetry while differing in the axial or equatorial position of the substituent (axial = 84(12) mol %/equatorial = 16(12) mol %) at T = 279(3) K, corresponding to an A value (Gax - Geq) of -1.0(4) kcal mol-1. Gas-phase CCSD(T) calculations predict an A value of -0.72 kcal mol-1 at 279 K. In contrast, the low-temperature 13C NMR experiments resulted in an axial/equatorial ratio of 35/65 mol % at 120 K corresponding to an A value of 0.14 kcal mol-1. An average value for ΔG#e→a = 5.6 ± 0.1 kcal mol-1 was obtained for the temperature range 110-145 K. The dramatically different conformational behaviour in the gas-phase (GED) compared to the liquid phase (DNMR) suggests a strong solvation effect. According to natural bond orbital analysis the axial conformer of the title compound is an example of stabilization of a form, which is not favored by electrostatic effects and is favored predominantly by steric and conjugation effects.

  6. 10 CFR 52.5 - Employee protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Employee protection. 52.5 Section 52.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General... of the appropriate U.S. Nuclear Regulatory Commission Regional Office listed in appendix D to part...

  7. 10 CFR 52.5 - Employee protection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Employee protection. 52.5 Section 52.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General... of the appropriate U.S. Nuclear Regulatory Commission Regional Office listed in appendix D to part...

  8. 10 CFR 52.5 - Employee protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Employee protection. 52.5 Section 52.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General... of the appropriate U.S. Nuclear Regulatory Commission Regional Office listed in appendix D to part...

  9. 10 CFR 140.5 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: ATTN: Document Control Desk, Director, Office of Nuclear Reactor Regulation, Director, Office of New Reactors, Director, Office of Federal and State Materials and Environmental Management Programs, or... 10 Energy 2 2010-01-01 2010-01-01 false Communications. 140.5 Section 140.5 Energy...

  10. 10 CFR 140.5 - Communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: ATTN: Document Control Desk, Director, Office of Nuclear Reactor Regulation, Director, Office of New Reactors, Director, Office of Federal and State Materials and Environmental Management Programs, or... 10 Energy 2 2011-01-01 2011-01-01 false Communications. 140.5 Section 140.5 Energy...

  11. 10 CFR 1048.5 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Violations. 1048.5 Section 1048.5 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) TRESPASSING ON STRATEGIC PETROLEUM RESERVE FACILITIES AND OTHER PROPERTY... regulations is subject to the maximum fine permitted by law, imprisonment for not more than one year, or both....

  12. 10 CFR 55.5 - Communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Communications. 55.5 Section 55.5 Energy NUCLEAR...) By mail addressed to—Director, Office of Nuclear Reactor Regulation or Director, Office of New Reactors, as appropriate, U.S. Nuclear Regulatory Commission, Washington, DC 20555-0001; or (2) By...

  13. 10 CFR 72.5 - Interpretations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Interpretations. 72.5 Section 72.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  14. 10 CFR 72.5 - Interpretations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Interpretations. 72.5 Section 72.5 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL RADIOACTIVE WASTE, AND REACTOR-RELATED GREATER THAN CLASS C WASTE General Provisions §...

  15. 10 CFR 904.5 - Revenue requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Revenue requirements. 904.5 Section 904.5 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON... which payment was deferred because of a deficiency in firm energy generation due to a shortage...

  16. 10 CFR 824.5 - Investigations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Investigations. 824.5 Section 824.5 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... scope, nature and extent of compliance by a person with DOE security requirements specified in §...

  17. 10 CFR 452.5 - Bidding procedures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Bidding procedures. 452.5 Section 452.5 Energy DEPARTMENT... cellulosic biofuels producers during the open window established in the solicitation. The open window shall.... (d) All bids will be confidential until 45 days after the close of the window for submission of...

  18. 10 CFR 452.5 - Bidding procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Bidding procedures. 452.5 Section 452.5 Energy DEPARTMENT... cellulosic biofuels producers during the open window established in the solicitation. The open window shall.... (d) All bids will be confidential until 45 days after the close of the window for submission of...

  19. Role of artificially created defects on magnetoimpedance of Co73Fe4.5Mn0.5Nb1.0Si4.2B16.8 ribbon

    NASA Astrophysics Data System (ADS)

    Manna, Subhendu Kumar; Srinivas, V.

    2016-11-01

    Microstructure and magnetoimpedance (MI) properties of soft magnetic Co73Fe4.5Mn0.5Nb1.0Si4.2B16.8 ribbons with artificial defects have been investigated. The holes of <0.5 mm diameter were created on 5 cm long amorphous ribbon to study the role of demagnetizatizing fields on MI. The MI ratio [MI(%)] decreased by 21% for ribbon with maximum 7 holes. Present results show that the anisotropy induced by artificial defects strongly influences the MI properties. However Joule annealing at an optimum condition enables one to reduce the anisotropy developed by the defects.

  20. Externally applied electric fields up to 1.6 × 10(5) V/m do not affect the homogeneous nucleation of ice in supercooled water.

    PubMed

    Stan, Claudiu A; Tang, Sindy K Y; Bishop, Kyle J M; Whitesides, George M

    2011-02-10

    The freezing of water can initiate at electrically conducting electrodes kept at a high electric potential or at charged electrically insulating surfaces. The microscopic mechanisms of these phenomena are unknown, but they must involve interactions between water molecules and electric fields. This paper investigates the effect of uniform electric fields on the homogeneous nucleation of ice in supercooled water. Electric fields were applied across drops of water immersed in a perfluorinated liquid using a parallel-plate capacitor; the drops traveled in a microchannel and were supercooled until they froze due to the homogeneous nucleation of ice. The distribution of freezing temperatures of drops depended on the rate of nucleation of ice, and the sensitivity of measurements allowed detection of changes by a factor of 1.5 in the rate of nucleation. Sinusoidal alternation of the electric field at frequencies from 3 to 100 kHz prevented free ions present in water from screening the electric field in the bulk of drops. Uniform electric fields in water with amplitudes up to (1.6 ± 0.4) × 10(5) V/m neither enhanced nor suppressed the homogeneous nucleation of ice. Estimations based on thermodynamic models suggest that fields in the range of 10(7)-10(8) V/m might cause an observable increase in the rate of nucleation.

  1. Transposons Tn10 and Tn5.

    PubMed

    Haniford, David B; Ellis, Michael J

    2015-02-01

    The study of the bacterial transposons Tn10 and Tn5 has provided a wealth of information regarding steps in nonreplicative DNA transposition, transpososome dynamics and structure, as well as mechanisms employed to regulate transposition. The focus of ongoing research on these transposons is mainly on host regulation and the use of the Tn10 antisense system as a platform to develop riboregulators for applications in synthetic biology. Over the past decade two new regulators of both Tn10 and Tn5 transposition have been identified, namely H-NS and Hfq proteins. These are both global regulators of gene expression in enteric bacteria with functions linked to stress-response pathways and virulence and potentially could link the Tn10 and Tn5 systems (and thus the transfer of antibiotic resistance genes) to environmental cues. Work summarized here is consistent with the H-NS protein working directly on transposition complexes to upregulate both Tn10 and Tn5 transposition. In contrast, evidence is discussed that is consistent with Hfq working at the level of transposase expression to downregulate both systems. With regard to Tn10 and synthetic biology, some recent work that incorporates the Tn10 antisense RNA into both transcriptional and translational riboswitches is summarized.

  2. Final report on bilateral supplementary comparison APMP.M.P-S5 in hydraulic gauge pressure from 1 MPa to 10 MPa

    NASA Astrophysics Data System (ADS)

    Yue, J.; Yang, Y.; Sabuga, W.

    2016-01-01

    This report summarizes the results of the Asia-Pacific Metrology Programme (APMP) supplementary comparison APMP.M.P-S5 for hydraulic gauge pressure in the range of 1 MPa to 10 MPa, which is a bilateral comparison carried out at the National Institute of Metrology, China (NIM) and the Physikalisch-Technische Bundesanstalt, Germany (PTB) during the period June 2014 to June 2015. NIM piloted the comparison and provided the transfer standard, which was a piston-cylinder assembly (PCA) of 1 cm2 nominal effective area built in a hydraulic pressure balance manufactured by Fluke Corporation. The laboratory standards of NIM and PTB are both hydraulic pressure balances equipped with PCAs, of which the nominal effective area is 1 cm2 for NIM and 5 cm2 for PTB. The results of the comparison successfully demonstrated that the hydraulic gauge pressure standards of NIM and PTB in the range of 1 MPa to 10 MPa are equivalent within their claimed uncertainties. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  3. Variability of aerosols and chemical composition of PM10, PM2.5 and PM1 on a platform of the Prague underground metro

    NASA Astrophysics Data System (ADS)

    Cusack, M.; Talbot, N.; Ondráček, J.; Minguillón, M. C.; Martins, V.; Klouda, K.; Schwarz, J.; Ždímal, V.

    2015-10-01

    Measurements of PM10, PM2.5 and PM1 and particle number concentration and size distribution were measured for 24 h on a platform of the Prague underground metro in October 2013. The three PM fractions were analysed for major and minor elements, secondary inorganic aerosols (SIA) and total carbon (TC). Measurements were performed both when the metro was inoperative and closed to the public (referred to as background), and when the metro was in operation and open to passengers. PM concentrations were elevated during both periods, but were substantially increased in the coarse fraction during hours when the metro was in operation. Average PM concentrations were 214.8, 93.9 and 44.8 μg m-3 for PM10, PM2.5 and PM1, respectively (determined gravimetrically). Average particle number concentrations were 8.5 × 103 cm-3 for background hours and 11.5 × 103 cm-3 during operational hours. Particle number concentrations were found to not vary as significantly as PM concentrations throughout the day. Variations in PM were strongly governed by passing trains, with highest concentrations recorded during rush hour. When trains were less frequent, PM concentrations were shown to fluctuate in unison with the entrance and exit of trains (as shown by wind velocity measured on the platform). PM was found to be highly enriched with iron, especially in the coarse fraction, comprising 46% of PM10 (98.9 μg m-3). This reduces to 6.7 μg m-3 during background hours, proving that the trains themselves were the main source of iron, most probably from wheel-rail mechanical abrasion. Other enriched elements relative to background hours included Ba, Cu, Mn, Cr, Mo, Ni and Co, among others. Many of these elements exhibited a similar size distribution, further indicating their sources were common and were attributed to train operations.

  4. Kerb and urban increment of highly time-resolved trace elements in PM10, PM2.5 and PM1.0 winter aerosol in London during ClearfLo 2012

    NASA Astrophysics Data System (ADS)

    Visser, S.; Slowik, J. G.; Furger, M.; Zotter, P.; Bukowiecki, N.; Dressler, R.; Flechsig, U.; Appel, K.; Green, D. C.; Tremper, A. H.; Young, D. E.; Williams, P. I.; Allan, J. D.; Herndon, S. C.; Williams, L. R.; Mohr, C.; Xu, L.; Ng, N. L.; Detournay, A.; Barlow, J. F.; Halios, C. H.; Fleming, Z. L.; Baltensperger, U.; Prévôt, A. S. H.

    2014-06-01

    Ambient concentrations of trace elements with 2 h time resolution were measured in PM10-2.5, PM2.5-1.0 and PM1.0-0.3 size ranges at kerbside, urban background and rural sites in London during winter 2012. Samples were collected using rotating drum impactors (RDIs) and subsequently analysed with synchrotron radiation-induced X-ray fluorescence spectrometry (SR-XRF). Quantification of kerb and urban increments (defined as kerb-to-urban and urban-to-rural concentration ratios, respectively), and assessment of diurnal and weekly variability provided insight into sources governing urban air quality and the effects of urban micro-environments on human exposure. Traffic-related elements yielded the highest kerb increments, with values in the range of 11.6 to 18.5 for SW winds (3.6-9.4 for NE) observed for elements influenced by brake wear (e.g. Cu, Sb, Ba) and 5.6 to 8.0 for SW (2.6-6.5 for NE) for other traffic-related processes (e.g. Cr, Fe, Zn). Kerb increments for these elements were highest in the PM10-2.5 mass fraction, roughly 3 times that of the PM1.0-0.3 fraction. These elements also showed the highest urban increments (∼3.0), although no difference was observed between brake wear and other traffic-related elements. Traffic-related elements exhibited higher concentrations during morning and evening rush hour, and on weekdays compared to weekends, with the strongest trends observed at the kerbside site, and additionally enhanced by winds coming directly from the road, consistent with street canyon effects. Elements related to mineral dust (e.g. Al, Ca, Sr) showed significant influences from traffic-induced resuspension, as evidenced by moderate kerb (2.0-4.1 for SW, 1.4-2.1 for NE) and urban (1.7-2.3) increments and increased concentrations during peak traffic flow. Elements related to regional transport showed no significant enhancement at kerb or urban sites, with the exception of PM10-2.5 sea salt (factor of 1.5-2.0), which may be influenced by traffic

  5. Developmental Exposure to 1.0 or 2.5 mg/kg of Dibutyltin Dichloride Does Not Impair Immune Function in Sprague-Dawley Rats.

    PubMed

    DeWitt, Jamie C; Copeland, Carey B; Luebke, Robert W

    2006-12-01

    Organotins are used commercially as pesticides, antifouling agents, and stabilizers for polyvinyl chloride (PVC) pipe. Mono-and di-substituted butyltins, used in PVC pipe production, are of concern to the United States EPA, they leach from supply pipes into drinking water and are reported multisystem toxicants. We assessed immune function in Sprague-Dawley rats after developmental dibutyltin dichloride (DBTC) exposure. Pregnant rats were given drinking water containing 0, 10, or 25 mg/L of DBTC (final concentration) in 0.5% Alkamuls from gestational Day (GD) 6 through weaning of pups (37 days total). Approximate doses to dams: 1 and 2.5 mg DBTC/kg body weight (BW) during gestation, or 2.0 and 4.4 mg DBTC/kg BW while nursing. Litters were sexed, weighed, and culled to 4 males and 4 females per dam on postnatal Day (PND) 2. Beginning on PND3, litters of half of the dams per dose were gavaged with 0, 1.0, or 2.5 mg DBTC/kg BW 3X/week for 10 doses (maternal + direct treatment); remaining litters were exposed indirectly via lactation (maternal treatment). BW of litters exposed to 2.5 mg DBTC/kg BW was 10-20% lower (p < or = 0.05) relative to other groups from PND14 (males) or PND17 (females) through PND37. Delayed-type hypersensitivity (DTH), antibody synthesis, and natural killer (NK) cell activity were evaluated in immunologically mature offspring (N = 6/sex/group). DTH responses and antibody synthesis did not differ by dose, sex, or exposure. NK cell activity in the 10 mg DBTC/L maternal only group was greater in male offspring than in female. In female offspring from the maternal + direct group, cytotoxicity increased by dose at the 25:1 effector:target cell ratio. Our data suggest that developmental immunotoxicity from DBTC-tainted drinking water is unlikely as the concentrations we used were several orders of magnitude higher than concentrations expected to leach from PVC pipes.

  6. Synthesis and biological evaluation of some 10-substituted 2,3-dihydroimidazo[2,1-b]quinazolin-5(10H)-ones, a new class of bronchodilators.

    PubMed

    Hardtmann, G E; Koletar, G; Pfister, O R; Gogerty, J H; Iorio, L C

    1975-05-01

    On treatment of N-substituted isatoic anhydrides with 2-methylmercaptoimidazolines, 10-substituted imidazo[2,1-b]quinazolin-5(10H)-ones are obtained. Several members of this class exhibited pronounced broncholytic activity. The structure-activity relationships (based on results obtained in the guinea pig histamine aerosol test) of these nonsympathomimetic bronchodilators are discussed. In addition, the detailed pharmacological evaluation of two analogs found to be five to ten times more active than theophyline as bronchodilators without having central nervous system or cardiovascular side effects is described.

  7. Increased Cellular Distribution of Vimentin and Ret in the Cingulum of Rat Offspring After Developmental Exposure to Decabromodiphenyl Ether or 1,2,5,6,9,10-Hexabromocyclododecane

    PubMed Central

    Fujimoto, Hitoshi; Woo, Gye-Hyeong; Morita, Reiko; Itahashi, Megu; Akane, Hirotoshi; Nishikawa, Akiyoshi; Shibutani, Makoto

    2013-01-01

    Abstract: To determine effects of developmental exposure to brominated flame retardants (BFRs), weak thyroid hormone disruptors, on white matter development, white matter-specific global gene expression analysis was performed using microdissection techniques and microarrays in male rats exposed maternally to decabromodiphenyl ether (DBDE), one of the representative BFRs, at 10, 100 or 1000 ppm. Based on previous gene expression profiles of developmental hypothyroidism and DBDE-exposed cases, vimentin+ immature astrocytes and ret proto-oncogene (Ret)+ oligodendrocytes were immunohistochemically examined after developmental exposure to representative BFRs, i.e., DBDE, 1,2,5,6,9,10-hexabromocyclododecane (HBCD; 100, 1000 or 10,000 ppm) and tetrabromobisphenol A (TBBPA; 100, 1000 or 10,000 ppm). Vimentin+ and Ret+ cell populations increased at ≥ 100 ppm and ≥ 10 ppm DBDE, respectively. Vimentin+ and Ret+ cells increased at ≥ 1000 ppm HBCD, with no effect of TBBPA. The highest dose of DBDE and HBCD revealed subtle fluctuations in serum thyroid-related hormone concentrations. Thus, DBDE and HBCD may exert direct effects on glial cell development at ≥ middle doses. At high doses, hypothyroidism may additionally be an inducing mechanism, although its contribution is rather minor. PMID:23914054

  8. 2-Chloro-N-{5-[(4R,5R,10S)-dehydro­abiet-4-yl]-1,3,4-thia­diazol-2-yl}benzamide

    PubMed Central

    Mo, Qijin; Duan, Wengui; Ma, Xianli; Huang, Jianxin; Ma, Zhen

    2011-01-01

    There are two independent mol­ecules in the asymmetric unit of the title compound, C28H32ClN3OS (systematic name: 2-chloro-N-{5-[(1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa­hydro­phenanthren-1-yl]-1,3,4-thia­diazol-2-yl}benzamide). In each mol­ecule, the cyclo­hexyl ring attached to the thia­diazole fragment adopts a classic chair conformation with two of its two methyl groups in the axial positions. In the crystal, pairs of inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into centrosymmetric dimers, which are further linked via C—H⋯π inter­actions. PMID:21754102

  9. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1511, LB4832_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1511, LB4832_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  10. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1212, LB4827_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1212, LB4827_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  11. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1111, LB4822_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1111, LB4822_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  12. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  13. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  14. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  15. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  16. 1 CFR 10.1 - Publication required.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication required. 10.1 Section 10.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Regular Publication § 10.1 Publication required. The Director publishes a special...

  17. Acid-base equilibria of various oxidation states of aqua-ruthenium complexes with 1,10-phenanthroline-5,6-dione in aqueous media.

    PubMed

    Fujihara, Tetsuaki; Wada, Tohru; Tanaka, Koji

    2004-02-21

    Syntheses and pH dependent electrochemical properties of aqua-ruthenium(II) complexes, [Ru(trpy)(PDA-N,N')(OH2)](ClO4)2 ([1](ClO4)2) and [Ru(trpy)(PD-N,N')(OH2)](ClO4)2 ([2](ClO4)2) (trpy = 2,2':6',2''-terpyridine, PDA = 6-acetonyl-6-hydroxy-1,10-phenanthroline-5-one, PD = 1,10-phenanthroline-5,6-dione) are presented. Treatment of [Ru(trpy)(PD-N,N')Cl](PF6) with AgClO4 in a mixed solvent of acetone and H2O selectively produced the acetonyl-PD complex [1](ClO4)2, and the similar treatment in a mixed solvent of 2-methoxyethanol and H2O gave the PD complex [2](ClO4)2. The molecular structures of both complexes were determined by X-ray structural analysis. The proton dissociation constants of various oxidations state of [1]2+ and [2]2+ were evaluated by simulation of E(1/2) values of those redox potentials depending on pH. The simulation revealed that the acetonyl-PD complex [1]2+ underwent successive Ru(II)/Ru(III) and Ru(III)/Ru(IV) redox couples though the two redox reactions were not separated in the cyclic voltammograms. The redox behavior of [2]2+ in H2O is reasonably explained by not only the similar successive metal-centered redox reactions but also simultaneous two-electron quinone/catechol redox couple of the PD ligand including the contribution of hydration on a carbonyl carbon.

  18. A triphenylamine-grafted imidazo[4,5-f][1,10]phenanthroline ruthenium(II) complex: acid-base and photoelectric properties.

    PubMed

    Fan, Su-Hua; Zhang, An-Guo; Ju, Chuan-Chuan; Gao, Li-Hua; Wang, Ke-Zhi

    2010-04-19

    A new heteroleptic ruthenium(II) complex of [Ru(Hipdpa)(Hdcbpy)(NCS)(2)](-).0.5H(+).0.5[N(C(4)H(9))(4)](+) Ru(Hipdpa) {where Hdcbpy = monodeprotonated 4,4'-dicarboxy-2,2'-bipyridine and Hipdpa = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline} was synthesized and characterized by elementary analysis, standard spectroscopy techniques, and cyclic voltammetry. The ground- and excited-state acid-base properties of Ru(Hipdpa) were studied by means of UV-vis absorption spectrophotometric and spectrofluorimetric titrations in 4:1(v/v) Britton-Robinson/dimethylformamide buffer solution. The four-step separate protonation/deprotonation processes were found in the ground states, and one of which taking place near the physiological pH range. The two observable excited-state protonation/deprotonation processes were found for the Ru(Hipdpa), constituting pH-induced "off-on-off" emission switches. The performance of the complexes as photosensitizers in nanocrystalline TiO(2)-based liquid solar cells containing an electrolyte solution (0.05 M I(2), 0.5 M LiI, and 0.5 M 4-tert-butylpyridine in 50% acetonitrile and 50% propylene carbonate) was investigated and found to achieve a much improved device performance (a short-circuit photocurrent density of 18.7 mA cm(-2), an open-circuit voltage of 630 mV, and an overall conversion efficiency of 6.85%) compared to a triphenylamine-free parent complex [Ru(Hpip)(Hdcbpy)(NCS)(2)](-).[N(C(4)H(9))(4)](+)-based device {Hpip = 2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline} and a comparable performance to that of cis-bis(isothiocyanato)bis(2,2'-bipyridine-4,4'-dicarboxylic acid)ruthenium(II) (N3) under identical experimental conditions. A density functional theory calculation of the molecular structures and electronic properties of the complexes was also carried out in an effort to understand their effectiveness in TiO(2)-based solar cells.

  19. [PhSiO1.5]8,10,12 as nanoreactors for non-enzymatic introduction of ortho, meta or para-hydroxyl groups to aromatic molecules.

    PubMed

    Bahrami, Mozhgan; Zhang, Xingwen; Ehsani, Morteza; Jahani, Yousef; Laine, Richard M

    2017-03-20

    Traditional electrophilic bromination follows long established "rules": electron-withdrawing substituents cause bromination selective for meta positions, whereas electron-donating substituents favor ortho and para bromination. In contrast, in the [PhSiO1.5]8,10,12 silsesquioxanes, the cages act as bulky, electron withdrawing groups equivalent to CF3; yet bromination under mild conditions, without a catalyst, greatly favors ortho substitution. Surprisingly, ICl iodination without a catalyst favors (>90%) para substitution [p-IC6H4SiO1.5]8,10,12. Finally, nitration and Friedel-Crafts acylation and sulfonylation are highly meta selective, >80%. In principle, the two halogenation formats coupled with the traditional electrophilic reactions provide selective functionalization at each position on the aromatic ring. Furthermore, halogenation serves as a starting point for the synthesis of two structural isomers of practical utility, i.e. in drug prospecting. The o-bromo and p-iodo compounds are easily modified by catalytic cross-coupling to append diverse functional groups. Thereafter, F(-)/H2O2 treatment cleaves the Si-C bonds replacing Si with OH. This represents a rare opportunity to introduce hydroxyl groups to aromatic rings, a process not easily accomplished using traditional organic synthesis methods. The as-produced phenol provides additional opportunities for modification. Each cage can be considered a nanoreactor generating 8-12 product molecules. Examples given include syntheses of 4,2'-R,OH-stilbenes and 4,4'-R,OH-stilbenes (R = Me, CN). Unoptimized cleavage of the Br/I derivatives yields 55-85% phenol. Unoptimized cleavage of the stilbene derivatives yields 35-40% (3-5 equivalents of phenol) in the preliminary studies presented here. In contrast, meta R-phenol yields are 80% (7-10 mol per cage).

  20. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.

    PubMed

    Watanabe, Yusuke; Zaffran, Stéphane; Kuroiwa, Atsushi; Higuchi, Hiroaki; Ogura, Toshihiko; Harvey, Richard P; Kelly, Robert G; Buckingham, Margaret

    2012-11-06

    During cardiogenesis, Fibroblast Growth Factor (Fgf10) is expressed in the anterior second heart field. Together with Fibroblast growth factor 8 (Fgf8), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of the heart. We have identified a 1.7-kb region in the first intron of Fgf10 that is necessary and sufficient to direct transgene expression in this cardiac context. The 1.7-kb sequence is directly controlled by T-box transcription factor 1 (Tbx1) in anterior second heart field cells that contribute to the outflow tract. It also responds to both NK2 transcription factor related, locus 5 (Nkx2-5) and ISL1 transcription factor, LIM/homeodomain (Islet1), acting through overlapping sites. Mutation of these sites reduces transgene expression in the anterior second heart field where the Fgf10 regulatory element is activated by Islet1 via direct binding in vivo. Analysis of the response to Nkx2-5 loss- and Isl1 gain-of-function genetic backgrounds indicates that the observed up-regulation of its activity in Nkx2-5 mutant hearts, reflecting that of Fgf10, is due to the absence of Nkx2-5 repression and to up-regulation of Isl1, normally repressed in the myocardium by Nkx2-5. ChIP experiments show strong binding of Nkx2-5 in differentiated myocardium. Molecular and genetic analysis of the Fgf10 cardiac element therefore reveals how key cardiac transcription factors orchestrate gene expression in the anterior second heart field and how genes, such as Fgf10, normally expressed in the progenitor cell population, are repressed when these cells enter the heart and differentiate into myocardium. Our findings provide a paradigm for transcriptional mechanisms that underlie the changes in regulatory networks during the transition from progenitor state to that of the differentiated tissue.

  1. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium

    PubMed Central

    Watanabe, Yusuke; Zaffran, Stéphane; Kuroiwa, Atsushi; Higuchi, Hiroaki; Ogura, Toshihiko; Harvey, Richard P.; Kelly, Robert G.; Buckingham, Margaret

    2012-01-01

    During cardiogenesis, Fibroblast Growth Factor (Fgf10) is expressed in the anterior second heart field. Together with Fibroblast growth factor 8 (Fgf8), Fgf10 promotes the proliferation of these cardiac progenitor cells that form the arterial pole of the heart. We have identified a 1.7-kb region in the first intron of Fgf10 that is necessary and sufficient to direct transgene expression in this cardiac context. The 1.7-kb sequence is directly controlled by T-box transcription factor 1 (Tbx1) in anterior second heart field cells that contribute to the outflow tract. It also responds to both NK2 transcription factor related, locus 5 (Nkx2-5) and ISL1 transcription factor, LIM/homeodomain (Islet1), acting through overlapping sites. Mutation of these sites reduces transgene expression in the anterior second heart field where the Fgf10 regulatory element is activated by Islet1 via direct binding in vivo. Analysis of the response to Nkx2-5 loss- and Isl1 gain-of-function genetic backgrounds indicates that the observed up-regulation of its activity in Nkx2-5 mutant hearts, reflecting that of Fgf10, is due to the absence of Nkx2-5 repression and to up-regulation of Isl1, normally repressed in the myocardium by Nkx2-5. ChIP experiments show strong binding of Nkx2-5 in differentiated myocardium. Molecular and genetic analysis of the Fgf10 cardiac element therefore reveals how key cardiac transcription factors orchestrate gene expression in the anterior second heart field and how genes, such as Fgf10, normally expressed in the progenitor cell population, are repressed when these cells enter the heart and differentiate into myocardium. Our findings provide a paradigm for transcriptional mechanisms that underlie the changes in regulatory networks during the transition from progenitor state to that of the differentiated tissue. PMID:23093675

  2. A Comparison Between GEBCO Sheet 5.17 and the International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 1.0

    NASA Astrophysics Data System (ADS)

    Jakobsson, Martin; Macnab, Ron

    2006-03-01

    In 1979, the General Bathymetric Chart of the Oceans (GEBCO) published Sheet 5.17 in the Fifth Edition of its series of global bathymetric maps. Sheet 5.17 covered the northern polar region above 64° N, and was for long the authoritative portrayal of Arctic bathymetry. The GEBCO compilation team had access to an extremely sparse sounding database from the central Arctic Ocean, due to the difficulty of mapping in this permanently ice covered region. In the past decade, there has been a substantial increase in the database of central Arctic Ocean bathymetry, due to the declassification of sounding data collected by US and British Navy nuclear submarines, and to the capability of modern icebreakers to measure ocean depths in heavy ice conditions. From these data sets, evidence has mounted to indicate that many of the smaller (and some larger) bathymetric features of Sheet 5.17 were poorly or wrongly defined. Within the framework of the project to construct the International Bathymetric Chart of the Arctic Ocean (IBCAO), all available historic and modern data sets were compiled to create a digital bathymetric model. In this paper, we compare both generally and in detail the contents of GEBCO Sheet 5.17 and version 1.0 of IBCAO, two bathymetric portrayals that were created more than 20 years apart. The results should be helpful in the analysis and assessment of previously published studies that were based on GEBCO Sheet 5.17.

  3. [C II] and {sup 12}CO(1-0) emission maps in HLSJ091828.6+514223: A strongly lensed interacting system at z = 5.24

    SciTech Connect

    Rawle, T. D.; Altieri, B.; Egami, E.; Rex, M.; Clement, B.; Bussmann, R. S.; Gurwell, M.; Fazio, G. G.; Ivison, R. J.; Boone, F.; Combes, F.; Danielson, A. L. R.; Smail, I.; Swinbank, A. M.; Edge, A. C.; Richard, J.; Blain, A. W.; Dessauges-Zavadsky, M.; Jones, T.; Kneib, J.-P.; and others

    2014-03-01

    We present Submillimeter Array [C II] 158 μm and Karl G. Jansky Very Large Array {sup 12}CO(1-0) line emission maps for the bright, lensed, submillimeter source at z = 5.2430 behind A 773: HLSJ091828.6+514223 (HLS0918). We combine these measurements with previously reported line profiles, including multiple {sup 12}CO rotational transitions, [C I], water, and [N II], providing some of the best constraints on the properties of the interstellar medium in a galaxy at z > 5. HLS0918 has a total far-infrared (FIR) luminosity L {sub FIR(8–1000} {sub μm)} = (1.6 ± 0.1) × 10{sup 14} L {sub ☉} μ{sup –1}, where the total magnification μ{sub total} = 8.9 ± 1.9, via a new lens model from the [C II] and continuum maps. Despite a HyLIRG luminosity, the FIR continuum shape resembles that of a local LIRG. We simultaneously fit all of the observed spectral line profiles, finding four components that correspond cleanly to discrete spatial structures identified in the maps. The two most redshifted spectral components occupy the nucleus of a massive galaxy, with a source-plane separation <1 kpc. The reddest dominates the continuum map (demagnified L {sub FIR,} {sub component} = (1.1 ± 0.2) × 10{sup 13} L {sub ☉}) and excites strong water emission in both nuclear components via a powerful FIR radiation field from the intense star formation. A third star-forming component is most likely a region of a merging companion (ΔV ∼ 500 km s{sup –1}) exhibiting generally similar gas properties. The bluest component originates from a spatially distinct region and photodissociation region analysis suggests that it is lower density, cooler, and forming stars less vigorously than the other components. Strikingly, it has very strong [N II] emission, which may suggest an ionized, molecular outflow. This comprehensive view of gas properties and morphology in HLS0918 previews the science possible for a large sample of high-redshift galaxies once ALMA attains full sensitivity.

  4. Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury.

    PubMed

    Petrosyan, H A; Alessi, V; Singh, V; Hunanyan, A S; Levine, J M; Arvanian, V L

    2014-12-01

    Adeno-associated viruses (AAVs) are a promising system for therapeutic gene delivery to neurons in a number of neurodegenerative conditions including spinal cord injuries (SCIs). Considering the role of macrophages and glia in the progression of 'secondary damage', we searched for the optimal vectors for gene transfer to both neurons and glia following contusion SCI in adult rats. Contusion models share many similarities to most human spinal cord traumas. Several AAV serotypes known for their neuronal tropism expressing enhanced green-fluorescent protein (GFP) were injected intraspinally following thoracic T10 contusion. We systematically compared the transduction efficacy and cellular tropism of these vectors for neurons, macrophages/microglia, oligodendrocytes, astrocytes and NG2-positive glial cells following contusion SCI. No additional changes in inflammatory responses or behavioral performance were observed for any of the vectors. We identified that AAV-rh10 induced robust transduction of both neuronal and glial cells. Even though efficacy to transduce neurons was comparable to already established AAV-1, AAV-5 and AAV-9, AAV-rh10 transduced significantly higher number of macrophages/microglia and oligodendrocytes in damaged spinal cord compared with other serotypes tested. Thus, AAV-rh10 carries promising potential as a gene therapy vector, particularly if both the neuronal and glial cell populations in damaged spinal cord are targeted.

  5. 28 CFR 5.801 - Activity beyond 10-day period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Activity beyond 10-day period. 5.801... AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.801 Activity beyond 10-day period. A registrant who has within the 10-day period filed an amendment to his registration statement pursuant to a Notice...

  6. 28 CFR 5.801 - Activity beyond 10-day period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Activity beyond 10-day period. 5.801... AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.801 Activity beyond 10-day period. A registrant who has within the 10-day period filed an amendment to his registration statement pursuant to a Notice...

  7. 28 CFR 5.801 - Activity beyond 10-day period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Activity beyond 10-day period. 5.801... AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.801 Activity beyond 10-day period. A registrant who has within the 10-day period filed an amendment to his registration statement pursuant to a Notice...

  8. 28 CFR 5.801 - Activity beyond 10-day period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Activity beyond 10-day period. 5.801... AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.801 Activity beyond 10-day period. A registrant who has within the 10-day period filed an amendment to his registration statement pursuant to a Notice...

  9. 28 CFR 5.801 - Activity beyond 10-day period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Activity beyond 10-day period. 5.801... AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.801 Activity beyond 10-day period. A registrant who has within the 10-day period filed an amendment to his registration statement pursuant to a Notice...

  10. Number size distribution, mass concentration, and particle composition of PM1, PM2.5, and PM10 in bag filling areas of carbon black production.

    PubMed

    Kuhlbusch, T A J; Neumann, S; Fissan, H

    2004-10-01

    Number size characteristics and PM10 mass concentrations of particles emitted during the packaging of various kinds of carbon blacks were measured continuously in the bag filling areas of three carbon black plants and concurrently at ambient comparison sites. PM10, PM2.5, and PM1 dust fractions were also determined in the bag filling areas. The filter samples were then analyzed for elemental and organic carbon. Comparisons of the measured number size distributions and mass concentrations during bag filling activities with those measured parallel at the ambient site and with those determined during nonworking periods in the work area enabled the characterization of emitted particles. PM10 mass concentrations were consistently elevated (up to a factor of 20 compared to ambient concentrations) during working periods in the bag filling area. Detailed analysis revealed that the carbon black particles released by bag filling activities had a size distribution starting at approximately 400 nm aerodynamic diameter (dae) with modes around 1 microm dae and > 8 microm dae. Ultrafine particles (< 100 nm dae), detected in the bag filling areas, were most likely attributed to noncarbon black sources such as forklift and gas heater emissions.

  11. Synthesis of the Stereoisomeric Clusters 1,2-Os3(CO)10(trans-dpmn) and 1,2-Os3(CO)10(cis-dpmn) [where dpmn = 2,3-bis(diphenylphosphinomethyl)-5-norbornene]: DFT Evaluation of the Isomeric Clusters 1,2-Os3(CO)10(dpmn) and Isomer-Dependent Diphosphine Ligand Activation

    DOE PAGES

    Yang, Li; Nesterov, Vladimir N.; Wang, Xiaoping; ...

    2014-07-23

    The bicyclic diphosphines trans- and cis-2,3-bis(diphenylphosphinomethyl)-5-norbornene (dpmn) react with 1,2-Os3(CO)10(MeCN)2 (1) to furnish the corresponding ligand-bridged clusters Os3(CO)10(trans-dpmn) (2) and Os3(CO)10(cis-dpmn) (3). Both new products have been isolated and the molecular structures established by X-ray diffraction analyses. The dihydroxyl-bridged cluster 1,2-Os3(CO)8(μ-OH)2(cis-dpmn) (4), which accompanied the formation of 3 in one reaction, has been isolated and characterized by mass spectrometry and X-ray crystallography. Whereas cluster 2 is stable in toluene at 373 K, 3 is thermally sensitive under identical conditions and undergoes loss of CO (2 equiv), coupled with the activation of three norbornene C-H bonds and one P-C(phenyl) bond, tomore » furnish the dihydride cluster H2Os3(CO)8[μ3-2-PhPC-3-endo-Ph2PCH2(C7H7)] (5). The solid-state structure of 5 confirms the multiple activation of the cis-dpmn ligand and accompanying formation of the face-capping 2-PhPC-3-endo-Ph2PCH2(C7H7) moiety in the product. DFT calculations on 2 and 3 indicate that the former cluster is the thermodynamically more stable isomer, and the conversion of 3→ 5 + 2CO + benzene is computed to be exergonic by 12.7 kcal/mol and is entropically favored due to the release of the CO and benzene by-products.« less

  12. Kerb and urban increment of highly time-resolved trace elements in PM10, PM2.5 and PM1.0 winter aerosol in London during ClearfLo 2012

    NASA Astrophysics Data System (ADS)

    Visser, S.; Slowik, J. G.; Furger, M.; Zotter, P.; Bukowiecki, N.; Dressler, R.; Flechsig, U.; Appel, K.; Green, D. C.; Tremper, A. H.; Young, D. E.; Williams, P. I.; Allan, J. D.; Herndon, S. C.; Williams, L. R.; Mohr, C.; Xu, L.; Ng, N. L.; Detournay, A.; Barlow, J. F.; Halios, C. H.; Fleming, Z. L.; Baltensperger, U.; Prévôt, A. S. H.

    2015-03-01

    Ambient concentrations of trace elements with 2 h time resolution were measured in PM10-2.5, PM2.5-1.0 and PM1.0-0.3 size ranges at kerbside, urban background and rural sites in London during winter 2012. Samples were collected using rotating drum impactors (RDIs) and subsequently analysed with synchrotron radiation-induced X-ray fluorescence spectrometry (SR-XRF). Quantification of kerb and urban increments (defined as kerb-to-urban and urban-to-rural concentration ratios, respectively), and assessment of diurnal and weekly variability provided insight into sources governing urban air quality and the effects of urban micro-environments on human exposure. Traffic-related elements yielded the highest kerb increments, with values in the range of 10.4 to 16.6 for SW winds (3.3-6.9 for NE) observed for elements influenced by brake wear (e.g. Cu, Sb, Ba) and 5.7 to 8.2 for SW (2.6-3.0 for NE) for other traffic-related processes (e.g. Cr, Fe, Zn). Kerb increments for these elements were highest in the PM10-2.5 mass fraction, roughly twice that of the PM1.0-0.3 fraction. These elements also showed the highest urban increments (~ 3.0), although no difference was observed between brake wear and other traffic-related elements. All elements influenced by traffic exhibited higher concentrations during morning and evening rush hours, and on weekdays compared to weekends, with the strongest trends observed at the kerbside site, and additionally enhanced by winds coming directly from the road, consistent with street canyon effects. Elements related to mineral dust (e.g. Al, Si, Ca, Sr) showed significant influences from traffic-induced resuspension, as evidenced by moderate kerb (3.4-5.4 for SW, 1.7-2.3 for NE) and urban (~ 2) increments and increased concentrations during peak traffic flow. Elements related to regional transport showed no significant enhancement at kerb or urban sites, with the exception of PM10-2.5 sea salt (factor of up to 2), which may be influenced by

  13. Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts.

    PubMed

    Kim, Byung-Wook; Kim, Byung-Chun; Cha, Jin Soon; Pfeifer, Gerd P; Lee, Chong-Soon

    2008-08-31

    1-Nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide are oxidative metabolites that are responsible for the mutagenicity of 1-nitropyrene. In this study, the mutation spectra induced by oxidative metabolites in human cells were determined using a shuttle vector assay. The mutation frequencies induced by 1-nitropyrene 9,10-oxide were 2-3 times higher than those induced by 1-nitropyrene 4,5-oxide. The base substitutions induced by 1-nitropyrene 4,5-oxide were G --> A transitions, G --> C transversions, and G --> T transversions. In the case of 1-nitropyrene 9,10-oxide, G --> A transitions, G --> T transversions, A --> G transitions and G --> C transversions were observed. Most base substitution mutations induced by oxidative metabolites occurred at the guanine sites in the supF gene. These sequence-specific hot spots were commonly identified as 5'-GA sequences for both metabolites. On the other hand, the sequence-specific hot spots at the adenine sites were identified as 5'-CAC sequences for 1-nitropyrene 9,10-oxide. These results suggest that the oxidative metabolites of 1-nitropyrene induce sequence-specific DNA mutations at the guanine and adenine sites at high frequency.

  14. 46 CFR 59.10-5 - Cracks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... APPURTENANCES Welding Repairs to Boilers and Pressure Vessels in -Service § 59.10-5 Cracks. (a) Cracks extending... corrugated furnaces may be repaired by welding provided any one crack does not exceed 20 inches in length. (e... any direction, nor more than a total of four cracks in a drum, and further provided the welding...

  15. Mechano-thermal synthesis of nanocrystalline RuSr2Eu1.5Ce0.5Cu2O10-δ materials: Micro-structural, optical and magnetic properties

    NASA Astrophysics Data System (ADS)

    Balamurugan, S.; Hussain, A. K. Jakkir; Parthiban, P.; Satya, A. T.; Janaki, J.

    2016-05-01

    The nanocrystalline RuSr2Eu1.5Ce0.5Cu2O10-δ (referred to as Ru1222Eu) materials were successfully prepared by mechano-thermal route and studied the Ru1222Eu materials by powder XRD, FT-IR, SEM-EDX and ac-susceptibility measurements. The as-milled powder annealed at 950 - 1000°C is crystallized in nearly single tetragonal phase of Ru1222Eu materials with average crystalline size of ~40 nm. Agglomeration of fine particles is seen through SEM micro-images in the Ru1222Eu phase materials. Contrary to magneto-superconductivity, a magnetic ordering is seen at ~60 K for Ru1222Eu phase under low applied field of 0.5 Oe at 10 Hz.

  16. Water detection by "turn on" fluorescence of the quinone-containing complexes [Ru(phen)2(1,10-phenanthroline-5,6-dione)2+] and [Ru(phenanthroline-5,6-dione)3]2+.

    PubMed

    Poteet, Steven A; MacDonnell, Frederick M

    2013-10-07

    Addition of water to the quinone functions in [Ru(phen)2(pdn)](2+) (1) and [Ru(pdn)3](2+) (2) (where phen = 1,10-phenanthroline and pdn = 1,10-phenanthroline-5,6-dione) turns on fluorescence at 605 nm, as formation of the geminal diol eliminates the predominant quinone-based non-radiative decay pathway and gives rise to a long-lived (3)MLCT state similar in nature to that seen in [Ru(phen)3](2+). Using NMR, the equilibrium constant for the hydration reaction of 1 in acetonitrile was determined to be 0.0253. From this data and experimental fitting of the luminescent titration data, the equilibrium constant for 2 of 1.62 × 10(-5) and emission yields for hydrated 1 and 2 were determined. Interestingly, all three quinone functions must be hydrated in 2 for luminescence, which is why the equilibrium constants vary so much. The 'turn on' luminescence allows for a very sensitive detection of water in aprotic solvents such as acetonitrile.

  17. A multivariate study for characterizing particulate matter (PM(10), PM(2.5), and PM(1)) in Seoul metropolitan subway stations, Korea.

    PubMed

    Kwon, Soon-Bark; Jeong, Wootae; Park, Duckshin; Kim, Ki-Tae; Cho, Kyung Hwa

    2015-10-30

    Given that around eight million commuters use the Seoul Metropolitan Subway (SMS) each day, the indoor air quality (IAQ) of its stations has attracted much public attention. We have monitored the concentration of particulate matters (PMx) (i.e., PM10, PM2.5, and PM1) in six major transfer stations per minute for three weeks during the summer, autumn, and winter in 2014 and 2015. The data were analyzed to investigate the relationship between PMx concentration and multivariate environmental factors using statistical methods. The average PM concentration observed was approximately two or three times higher than outdoor PM10 concentration, showing similar temporal patterns at concourses and platforms. This implies that outdoor PM10 is the most significant factor in controlling indoor PM concentration. In addition, the station depth and number of trains passing through stations were found to be additional influences on PMx. Principal component analysis (PCA) and self-organizing map (SOM) were employed, through which we found that the number of trains influences PM concentration in the vicinity of platforms only, and PMx hotspots were determined. This study identifies the external and internal factors affecting PMx characteristics in six SMS stations, which can assist in the development of effective IAQ management plans to improve public health.

  18. 40 CFR Table C-4 to Subpart C of... - Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...% 10% 2 10% 2 10% 2 10% 2 Precision of PM2.5 or PM10-2.5 candidate method, CP, each site 10% 2 15% 2 15% 2 15% 2 Slope of regression relationship 1 ±0.10 1 ±0.05 1 ±0.10 1 ±0.10 1 ±0.10 1 ±0.12...

  19. Measurement of the 10B(p ,α0)7Be cross section from 5 keV to 1.5 MeV in a single experiment using the Trojan horse method

    NASA Astrophysics Data System (ADS)

    Spitaleri, C.; Puglia, S. M. R.; La Cognata, M.; Lamia, L.; Cherubini, S.; Cvetinović, A.; D'Agata, G.; Gulino, M.; Guardo, G. L.; Indelicato, I.; Pizzone, R. G.; Rapisarda, G. G.; Romano, S.; Sergi, M. L.; Spartá, R.; Tudisco, S.; Tumino, A.; Del Santo, M. Gimenez; Carlin, N.; Munhoz, M. G.; Souza, F. A.; de Toledo, A. Szanto; Mukhamedzhanov, A.; Broggini, C.; Caciolli, A.; Depalo, R.; Menegazzo, R.; Rigato, V.; Lombardo, I.; Dell'Aquila, D.

    2017-03-01

    For the first time the astrophysical factor of the 10B(p ,α0)7Be reaction has been measured over a wide energy range, from 5 keV to 1.5 MeV, via the Trojan horse method (THM) applied to the quasifree 2H(10B,α 7Be)n reaction. Therefore, the S (E ) factor has been recast into absolute units by scaling in the energy range 200 keV-1.2 MeV to a recent measurement using the activation method, leading to a normalization uncertainty of 4 % . An R -matrix fit of the THM data was performed, to parametrize the S factor, obtain spectroscopic information on the populated resonances, and compare with other recent experiments. Finally, a new determination of the screening potential Ue has been obtained, Ue=240 ±50 eV, with a much smaller error than our previous measurement.

  20. The Funnybone Family Saga. [Level 1, Books 1-5; Level 2, Books 6-10.] XYZ-Rated: For Adults Only. Basic Skills Series.

    ERIC Educational Resources Information Center

    Wise, John

    A series of 10 high-interest, low-vocabulary reading books for adult basic education students is presented. The series begins with very simple vocabulary and gets progressively more difficult from book to book. Each book contains from four to six stories which focus on the lives and relationships of a variety of humorous characters living in a…

  1. Synthesis, Characterization and Copper Chemistry of a Non-symmetric Ligand: 2-Methyl-9-(3,5-dimethyl-N-pyrazolylmethyl)-1,10-phenanthroline.

    PubMed

    Masood, Md Athar; Storr, Tim; Stack, T Daniel P

    2008-03-03

    The synthesis of an unsymmetrical phenanthroline based ligand, 2-methyl-9-(3,5-dimethylpyrazolylmethyl)-1,10-phenanthroline (L), and its cupric [Cu(II)] (1) and cuprous [Cu(I)] (2) complexes, are reported. The X-ray structures of each of these Cu complexes show distinct changes in coordination environments consistent with the geometrical preferences of the two oxidation states. In the solid state the Cu(II) complex (1) adopts a geometry best described as trigonal bipyramidal, while the Cu(I) complex (2) consists of a single dicationic dimer in which the ligand bridges between two copper ions, separated by 4.26 Å. The two Cu(I) coordination sites differ in 2 with one copper center complexed in a trigonal planar geometry and the other copper in a distorted tetrahedral environment; the latter coordination results from an additional CH(3)CN ligand. Complex 1 exhibits a reversible redox process at -0.34 V vs. Fc/Fc(+) in CH(3)CN, attributable to the Cu(2+)/Cu(+) couple, while the dimeric Cu(I) complex (2) is resistant to oxidation on the CV timescale. Over minutes however, complex 1 does oxidize in the presence of dioxygen to 2 in CH(3)CN.

  2. Synthesis, Characterization and Copper Chemistry of a Non-symmetric Ligand: 2-Methyl-9-(3,5-dimethyl-N-pyrazolylmethyl)-1,10-phenanthroline

    PubMed Central

    Masood, Md. Athar; Storr, Tim; Stack, T. Daniel P.

    2008-01-01

    The synthesis of an unsymmetrical phenanthroline based ligand, 2-methyl-9-(3,5-dimethylpyrazolylmethyl)-1,10-phenanthroline (L), and its cupric [Cu(II)] (1) and cuprous [Cu(I)] (2) complexes, are reported. The X-ray structures of each of these Cu complexes show distinct changes in coordination environments consistent with the geometrical preferences of the two oxidation states. In the solid state the Cu(II) complex (1) adopts a geometry best described as trigonal bipyramidal, while the Cu(I) complex (2) consists of a single dicationic dimer in which the ligand bridges between two copper ions, separated by 4.26 Å. The two Cu(I) coordination sites differ in 2 with one copper center complexed in a trigonal planar geometry and the other copper in a distorted tetrahedral environment; the latter coordination results from an additional CH3CN ligand. Complex 1 exhibits a reversible redox process at −0.34 V vs. Fc/Fc+ in CH3CN, attributable to the Cu2+/Cu+ couple, while the dimeric Cu(I) complex (2) is resistant to oxidation on the CV timescale. Over minutes however, complex 1 does oxidize in the presence of dioxygen to 2 in CH3CN. PMID:19430538

  3. Characterizing metal(loid) solubility in airborne PM10, PM2.5 and PM1 in Frankfurt, Germany using simulated lung fluids

    NASA Astrophysics Data System (ADS)

    Wiseman, Clare L. S.; Zereini, Fathi

    2014-06-01

    The purpose of this study is to assess the solubility of traffic-related metal(loid)s associated with airborne PM of human health concern, employing a physiologically-based extraction test with simulated lung fluids (artificial lysosomal fluid (ALF) and Gamble's solution). Airborne PM (PM10, PM2.5 and PM1) samples were collected in Frankfurt am Main, Germany, using a high volume sampler. Following extraction of the soluble metal(loid) fractions, sample filters were digested with a high pressure asher. Metal(loid) concentrations (As, Ce, Co, Cr, Cu, Mn, Ni, Pb, Sb, Ti and V) were determined in extracts and digests per ICP-Q-MS. All metal(loid)s occurred at detectable concentrations in the three airborne PM fractions. Copper was the most abundant element in mass terms, with mean concentrations of 105 and 53 ng/m3 in PM10 and PM2.5, respectively. Many of the metal(loid)s were observed to be soluble in simulated lung fluids, with Cu, As, V and Sb demonstrating the highest overall mobility in airborne PM. For instance, all four elements associated with PM10 had a solubility of >80% in ALF (24 h). Clearly, solubility is strongly pH dependent, as reflected by the higher relative mobility of samples extracted with the acidic ALF. Given their demonstrated solubility, this study provides indirect evidence that a number of toxic metal(loid)s are likely to possess an enhanced pulmonary toxic potential upon their inhalation. The co-presence of many toxic elements of concern in airborne PM suggests an assessment of health risk must consider the possible interactive impacts of multi-element exposures.

  4. Clastogenic action of hydroperoxy-5,8,11,13-icosatetraenoic acids on the mouse embryo fibroblasts C3H/10T1/2.

    PubMed Central

    Ochi, T; Cerutti, P A

    1987-01-01

    Phorbol 12-myristate 13-acetate induces the release of a low molecular weight clastogenic factor from monocytes. Hydroperoxy-5,8,11,13-icosatetraenoic acids represent major components of clastogenic factor. We report that several isomeric hydroperoxy-5,8,11,13-icosatetraenoic acids efficiently induce DNA strand breakage and/or alkali-labile sites in the mouse embryo fibroblasts C3H/10T1/2. Fe chelation by desferrioxamine suppresses breakage by approximately equal to 42% indicating the participation of Fe-catalyzed radical reactions. An additional 37% inhibition is observed upon addition of the Ca2+ chelators EGTA and quin-2. This result suggests that hydroxyperoxy-5,8,11,13-icosatetraenoic acid may activate a Ca2+-dependent nuclease. The addition of the antioxidant enzymes CuZn-superoxide dismutase and catalase had no effect, while glutathione peroxidase suppressed strand breakage by 90%. To our knowledge, our results yield a first insight into the mechanism of action of monocyte clastogenic factor and the role of inflammation in tumor promotion. PMID:3469656

  5. Volumetric Properties of the Mixture Diethyl carbonate C5H10O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1511, LB4522_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume C 'Binary Liquid Systems of Nonelectrolytes III' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Diethyl carbonate C5H10O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1511, LB4522_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  6. A 5-(difluorenyl)-1,10-phenanthroline-based Ru(II) complex as a coating agent for potential multifunctional gold nanoparticles.

    PubMed

    Moreau, Juliette; Lux, François; Four, Mickaël; Olesiak-Banska, Joanna; Matczyszyn, Katarzyna; Perriat, Pascal; Frochot, Céline; Arnoux, Philippe; Tillement, Olivier; Samoc, Marek; Ponterini, Glauco; Roux, Stéphane; Lemercier, Gilles

    2014-07-28

    The synthesis and photophysical properties of small gold nanoparticles (NPs, AuNP-[Ru-PFF]) surface functionalized by 5-substituted-1,10-phenanthroline-ligand based Ru(II) complexes are described. Luminescence of the grafted and confined Ru(II) complexes is totally quenched on the gold surface. Nonlinear optical properties were determined via Z-scan measurements in the range 600-1300 nm for both the free Ru(II) complex and the related NPs. In the short wavelength range (around 600 nm) the behaviour switches from that of two-photon absorption (2PA) for the complex to saturable absorption for the NPs. 2PA applications such as optical power limiting or two-photon dioxygen sensitization can be anticipated for these nanoplatforms.

  7. 1,10-Phenanthrolinium ionic liquid crystals.

    PubMed

    Cardinaels, Thomas; Lava, Kathleen; Goossens, Karel; Eliseeva, Svetlana V; Binnemans, Koen

    2011-03-01

    The 1,10-phenanthrolinium cation is introduced as a new building block for the design of ionic liquid crystals. 1,10-Phenanthroline, 5-methyl-1,10-phenanthroline, 5-chloro-1,10-phenanthroline, and 4,7-diphenyl-1,10-phenanthroline were quaternized by reaction with 1,3-dibromopropane or 1,2-dibromoethane. The resulting cations were combined with dodecyl sulfate or dioctyl sulfosuccinate anions. The influence of both the cation and anion type on the thermal behavior was investigated. Several of the complexes exhibit mesomorphic behavior, with smectic E phases for the dodecyl sulfate salts and smectic A phases for the dioctyl sulfosuccinate salts. Structural models for the packing of the 1,10-phenanthrolinium and anionic moieties in the liquid-crystalline phases are presented. The ionic compounds show fluorescence in the solid state and in solution.

  8. 10 CFR 5.435 - Employment assistance to students.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Employment assistance to students. 5.435 Section 5.435... Activities Prohibited § 5.435 Employment assistance to students. (a) Assistance by recipient in making... employment available to any of its students: (1) Shall assure itself that such employment is made...

  9. 10 CFR 5.435 - Employment assistance to students.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Employment assistance to students. 5.435 Section 5.435... Activities Prohibited § 5.435 Employment assistance to students. (a) Assistance by recipient in making... employment available to any of its students: (1) Shall assure itself that such employment is made...

  10. 10 CFR 5.435 - Employment assistance to students.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Employment assistance to students. 5.435 Section 5.435... Activities Prohibited § 5.435 Employment assistance to students. (a) Assistance by recipient in making... employment available to any of its students: (1) Shall assure itself that such employment is made...

  11. 10 CFR 5.435 - Employment assistance to students.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Employment assistance to students. 5.435 Section 5.435... Activities Prohibited § 5.435 Employment assistance to students. (a) Assistance by recipient in making... employment available to any of its students: (1) Shall assure itself that such employment is made...

  12. 10 CFR 5.435 - Employment assistance to students.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Employment assistance to students. 5.435 Section 5.435... Activities Prohibited § 5.435 Employment assistance to students. (a) Assistance by recipient in making... employment available to any of its students: (1) Shall assure itself that such employment is made...

  13. Force supplementary comparison EURAMET.M.F-S3 (1 kN, 2 kN, 5 kN, and 10 kN)

    NASA Astrophysics Data System (ADS)

    Knott, A.; Machado, R. R.

    2016-01-01

    This report describes EURAMET supplementary comparison EURAMET.M.F-S3, a comparison between the 20 kN force standard machine of NPL and the 10 kN force standard machine of INMETRO, at generated forces of 1 kN, 2 kN, 5 kN, and 10 kN, in both tension and compression, with both incremental and decremental loading. Two different transducers were used and the force-time profile was strictly controlled, to minimise effects of creep. At all four force levels, the results demonstrate that there is no evidence that either machine fails to generate forces in accordance with its CMC. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  14. Enhanced negative thermal expansion in La(1-x)Pr(x)Fe10.7Co0.8Si1.5 compounds by doping the magnetic rare-earth element praseodymium.

    PubMed

    Li, Wen; Huang, Rongjin; Wang, Wei; Tan, Jie; Zhao, Yuqiang; Li, Shaopeng; Huang, Chuanjun; Shen, Jun; Li, Laifeng

    2014-06-02

    Experiments have been performed to enhance negative thermal expansion (NTE) in the La(Fe,Co,Si)13-based compounds by optimizing the chemical composition, i.e., proper substitution of La by magnetic element Pr. It is found that increasing the absolute value of the average coefficient of thermal expansion (CTE) in the NTE temperature region (200-300 K) attributes to enhancement of the spontaneous magnetization and its growth rate with increasing Pr content. Typically, the average CTE of La(1-x)Pr(x)Fe10.7Co0.8Si1.5 with x = 0.5 reaches as large as -38.5 × 10(-6) K(-1) between 200 and 300 K (ΔT = 100 K), which is 18.5% larger than that of x = 0. The present results highlight the potential applications of La(Fe,Co,Si)13-based compounds with a larger NTE coefficient.

  15. Iron-rich low-cost superalloys. [Cr(15)-Mn(15)-Mo(2)-C(1. 5)-Si(1. 0)-Nb(1. 0)-Fe(bal. ) and Cr(20)-Mn(10)-C(3. 4)-Fe(bal. )

    SciTech Connect

    Wayne, S.F.

    1985-01-01

    An iron-rich low-cost superalloy has been developed in conjunction with United Technologies Research Center under the NASA program, Conservation of Strategic Aerospace Materials. The alloy, when processed by conventional chill casting, has physical and mechanical properties that compare favorably with existing nickel - and cobalt-based superalloys while containing significantly lower amounts of strategic elements. The composition of the alloy is Cr(15)-Mn(15)-Mo(2)-C(1.5)-Si(1.0)-Nb(1.0)-Fe(bal.), and it can be produced with chromite ore deposits located within the United States. Studies were also made on the properties of Cr(20)-Mn(10)-C(3.4)-Fe(bal.), a eutectic alloy processed by chill casting and directional solidification (D.S.) which produced an aligned microstructure consisting of M/sub 7/C/sub 3/ fibers in an ..gamma..-Fe matrix. This good alignment vanishes when molybdenum or aluminum is added in higher concentrations. Thermal expansion of the M/sub 7/C/sub 3/ (M = Fe, Cr, Mn) carbide lattice was measured up to 800/sup 0/C and found to be highly anisotropic, with the a-axis being the predominant mode of expansion. Repetitive impact-sliding wear experiments performed with the Fe-rich eutectic alloy showed that the directionally solidified microstructure greatly improved the alloy's wear resistance as compared to the chill-cast microstructure and conventional nickel-base superalloys.

  16. Sensitive and selective determination of GSH based on the ECL quenching of Ru(II) 1,10-phenanthroline-5,6-dione complex.

    PubMed

    Xu, Yanxue; Zhang, Lei; Liu, Yuan; Jin, Zhaoyu; Zhao, Qian; Yang, Feng; Xiao, Dan

    2016-03-15

    Electrochemiluminescence (ECL) material Ru-dpq (Ru(bpy)2dpq(2+), dpq=1,10-phenanthroline-5,6-dione; bpy=2,2'-bipyridine) is found to be produced strong and stable anodic ECL signal, which could be quenched by reduced glutathione (GSH) and exhibits high sensitivity and selectivity simultaneously. According to the mass spectra of Ru-SG (product of Ru-dpq reacted with GSH), and single crystal structure of the final oxidized product Ru-dcbpy ((Ru(bpy)2dcbpy(2+), dcbpy=3,3-dicarboxy-2,2-bipyridine), we propose a new interacted mechanism between Ru-dpq and GSH. A good linear relation is estimated to be from 0.1 pM to 50 μM in the presence of calcium ion and the detection limit is as low as 0.087 pM (with the signal-to-noise ratio of 3). The relative standard deviation is 2.3% (for three repeated measurements). Furthermore, the ECL signal of Ru-dpq under a constant potential (1.2V) is extremely stable and the intensity could be maintained over 600 s, which promotes us to determine the concentration of GSH via chronoamperometry.

  17. 33 CFR 49.10-5 - Payment of moneys due.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Payment of moneys due. 49.10-5... PAYMENT OF AMOUNTS DUE MENTALLY INCOMPETENT COAST GUARD PERSONNEL Reports and Moneys § 49.10-5 Payment of moneys due. Upon the appointment of a trustee or trustees to receive moneys due an incompetent,...

  18. 33 CFR 49.10-5 - Payment of moneys due.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Payment of moneys due. 49.10-5... PAYMENT OF AMOUNTS DUE MENTALLY INCOMPETENT COAST GUARD PERSONNEL Reports and Moneys § 49.10-5 Payment of moneys due. Upon the appointment of a trustee or trustees to receive moneys due an incompetent,...

  19. 33 CFR 49.10-5 - Payment of moneys due.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Payment of moneys due. 49.10-5... PAYMENT OF AMOUNTS DUE MENTALLY INCOMPETENT COAST GUARD PERSONNEL Reports and Moneys § 49.10-5 Payment of moneys due. Upon the appointment of a trustee or trustees to receive moneys due an incompetent,...

  20. 33 CFR 49.10-5 - Payment of moneys due.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Payment of moneys due. 49.10-5... PAYMENT OF AMOUNTS DUE MENTALLY INCOMPETENT COAST GUARD PERSONNEL Reports and Moneys § 49.10-5 Payment of moneys due. Upon the appointment of a trustee or trustees to receive moneys due an incompetent,...

  1. 33 CFR 49.10-5 - Payment of moneys due.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Payment of moneys due. 49.10-5... PAYMENT OF AMOUNTS DUE MENTALLY INCOMPETENT COAST GUARD PERSONNEL Reports and Moneys § 49.10-5 Payment of moneys due. Upon the appointment of a trustee or trustees to receive moneys due an incompetent,...

  2. 36 CFR 5.10 - Eating, drinking, or lodging establishments.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Rocky Mountain, Sequoia-Kings Canyon, Yellowstone, and Yosemite National Parks may be operated without a... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false Eating, drinking, or lodging establishments. 5.10 Section 5.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF...

  3. 36 CFR 5.10 - Eating, drinking, or lodging establishments.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Rocky Mountain, Sequoia-Kings Canyon, Yellowstone, and Yosemite National Parks may be operated without a... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Eating, drinking, or lodging establishments. 5.10 Section 5.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF...

  4. 36 CFR 5.10 - Eating, drinking, or lodging establishments.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Rocky Mountain, Sequoia-Kings Canyon, Yellowstone, and Yosemite National Parks may be operated without a... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Eating, drinking, or lodging establishments. 5.10 Section 5.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF...

  5. 36 CFR 5.10 - Eating, drinking, or lodging establishments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Rocky Mountain, Sequoia-Kings Canyon, Yellowstone, and Yosemite National Parks may be operated without a... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Eating, drinking, or lodging establishments. 5.10 Section 5.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF...

  6. 36 CFR 5.10 - Eating, drinking, or lodging establishments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Rocky Mountain, Sequoia-Kings Canyon, Yellowstone, and Yosemite National Parks may be operated without a... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Eating, drinking, or lodging establishments. 5.10 Section 5.10 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF...

  7. 18 CFR 5.10 - Scoping Document 2.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Scoping Document 2. 5.10 Section 5.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  8. 18 CFR 5.10 - Scoping Document 2.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Scoping Document 2. 5.10 Section 5.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  9. 18 CFR 5.10 - Scoping Document 2.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Scoping Document 2. 5.10 Section 5.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  10. 33 CFR 67.10-5 - Location requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for...

  11. 33 CFR 67.10-5 - Location requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for...

  12. 33 CFR 67.10-5 - Location requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for...

  13. 33 CFR 67.10-5 - Location requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for...

  14. 33 CFR 67.10-5 - Location requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Location requirements. 67.10-5 Section 67.10-5 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION AIDS TO NAVIGATION ON ARTIFICIAL ISLANDS AND FIXED STRUCTURES General Requirements for...

  15. 9 CFR 75.5-75.10 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false 75.5-75.10 Section 75.5-75.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMUNICABLE DISEASES IN HORSES, ASSES,...

  16. 18 CFR 5.10 - Scoping Document 2.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Scoping Document 2. 5.10 Section 5.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION..., the Commission staff shall, if necessary, issue Scoping Document 2....

  17. 18 CFR 5.10 - Scoping Document 2.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Scoping Document 2. 5.10 Section 5.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION..., the Commission staff shall, if necessary, issue Scoping Document 2....

  18. 9 CFR 75.5-75.10 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false 75.5-75.10 Section 75.5-75.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMUNICABLE DISEASES IN HORSES, ASSES,...

  19. 9 CFR 75.5-75.10 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false 75.5-75.10 Section 75.5-75.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMUNICABLE DISEASES IN HORSES, ASSES,...

  20. 9 CFR 75.5-75.10 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false 75.5-75.10 Section 75.5-75.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMUNICABLE DISEASES IN HORSES, ASSES,...

  1. 9 CFR 75.5-75.10 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false 75.5-75.10 Section 75.5-75.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS COMMUNICABLE DISEASES IN HORSES, ASSES,...

  2. Syllabic (∼2-5 Hz) and fluctuation (∼1-10 Hz) ranges in speech and auditory processing.

    PubMed

    Edwards, Erik; Chang, Edward F

    2013-11-01

    Given recent interest in syllabic rates (∼2-5 Hz) for speech processing, we review the perception of "fluctuation" range (∼1-10 Hz) modulations during listening to speech and technical auditory stimuli (AM and FM tones and noises, and ripple sounds). We find evidence that the temporal modulation transfer function (TMTF) of human auditory perception is not simply low-pass in nature, but rather exhibits a peak in sensitivity in the syllabic range (∼2-5 Hz). We also address human and animal neurophysiological evidence, and argue that this bandpass tuning arises at the thalamocortical level and is more associated with non-primary regions than primary regions of cortex. The bandpass rather than low-pass TMTF has implications for modeling auditory central physiology and speech processing: this implicates temporal contrast rather than simple temporal integration, with contrast enhancement for dynamic stimuli in the fluctuation range. This article is part of a Special Issue entitled "Communication Sounds and the Brain: New Directions and Perspectives".

  3. Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione.

    PubMed

    Song, Yu-Min; Xu, Jun-Peng; Ding, Lan; Hou, Qian; Liu, Jing-Wang; Zhu, Zao-Long

    2009-03-01

    Three new solid complexes have been synthesized by the reaction of rare earth(III) nitrate with the first ligand curcumin (HL) and the second ligand 1,10-phenanthroline-5,6-dione (L') in alcohol solution (pH=6.5-7.0). The composition of the complexes has been characterized by elemental analysis, molar conductivity, thermogravimetric analysis, IR, UV-vis methods. The results reveal that beta-diketone group of the first ligand to coordinates with rare earth ions in bidentate mode after deprotonated. But the second ligand uses its two N atoms coordinates with rare earth ions in bidentate mode. The general formula of the complexes is REL(3)L' (RE=Sm, Eu, Dy). The results of antibacterial activity indicated that the complexes have excellent antibacterial ability for the testing bacterium than that of curcumin. The result of agarose gel electrophoresis suggested that the complex of SmL(3)L' can cleave the plasmid DNA at physiological pH and temperature. And it was found that the cleavage process of plasmid DNA was sensitive to pH, however, adding radical scavengers almost had no effect on the DNA cleavage reaction, therefore, the cleavage of DNA by SmL(3)L' does not produce diffusible hydroxyl radicals via the Fenton reaction.

  4. Composition related magnetic properties and coercivity mechanism for melt spun [(La0.5Ce0.5)1-xREx]10Fe84B6 (RE=Nd or Dy) nanocomposite alloys

    NASA Astrophysics Data System (ADS)

    Hussain, M.; Liu, J.; Zhao, L. Z.; Zhong, X. C.; Zhang, G. Q.; Liu, Z. W.

    2016-02-01

    Room temperature magnetic properties and coercivity mechanisms for nanocomposites [(La0.5Ce0.5)1-xREx]10Fe84B6 (RE=Nd or Dy; x=0, 0.3, 0.5, and 0.7) alloys prepared by melt-spinning have been investigated. Nd and Dy substitutions can improve the hard magnetic properties, especially the coercivity of [(La0.5Ce0.5)]10Fe84B6 alloy. The largest values of intrinsic coercivity Hc and maximum energy product (BH)max for the Dy substituted alloys are 714 kA/m and 41 kJ/m3, respectively, whereas for Nd substituted alloys, Hc=365 kA/m and (BH)max=120 kJ/m3 were obtained for x=0.7. The different elevated temperature behaviors were also found for Nd and Dy added alloys. The composition dependent coercivity mechanisms for Dy and Nd substituted alloys are evident based on the temperature dependence of coercivity described by domain wall pinning and reverse domain nucleation models. It is found that the domain wall pinning mechanism is possibly responsible for [(LaCe)Nd]FeB alloys while reverse domain nucleation is more likely responsible for[(LaCe)Dy]FeB alloys.

  5. 2-Hy­droxy-2,3,5,10,11,11a-hexa­hydro-1H-pyrrolo­[2,1-c][1,4]benzodiazepine-5,11-dione

    PubMed Central

    Ourahou, Sarah; Zouihri, Hafid; Massoui, Mohamed; Essassi, El Mokhtar; Ng, Seik Weng

    2011-01-01

    The seven-membered ring of the title compound, C12H12N2O3, which is fused with the phenyl­ene ring, adopts a boat-shaped conformation (with the methine C atom as the prow and the phenyl­ene C atoms as the stern); the H atom on the methine linkage exists in an axial position. The five-membered ring that is fused with the seven-membered ring adopts an envelope conformation (with the C atom bearing the hy­droxy substituent representing the flap) [the deviation from the plane defined by the other four atoms is 0.200 (7) Å in one mol­ecule and 0.627 (5) Å in the other]. The two independent mol­ecules are disposed about a pseudo center of inversion and are connected by a pair of N—H⋯O hydrogen bonds. Adjacent dimers are linked by a pair of O—H⋯O hydrogen bonds, generating a chain running along the b axis. PMID:22090956

  6. Spectral investigation of the effect of anion on the stability of non covalent assemblies of 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine (benzo-15-crown-5) with sodium halides

    NASA Astrophysics Data System (ADS)

    Ghildiyal, Namrata; Pant, Geeta Joshi nee; Rawat, M. S. M.; Singh, Khushboo

    2017-01-01

    A series of complexes of 2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecine (benzo-15-crown-5) with sodium halides was synthesized in acetonitrile. The effect of anion on the stability and spectral properties of complexes of benzo-15-crown-5 with sodium halides was investigated. The synthesis of complexes of sodium fluoride and sodium chloride are reported for the first time. Chloroform was used as solvent to study the assembly in solution state by 1H and 13C NMR techniques. Single crystal diffraction studies on the easily crystallizable bromide complex confirmed 1:1 stoichiometry of the complex. IR and Raman studies provided valuable evidence for a water molecule shared between the crown encapsulated cation and the counter ion to give a solvent shared ion pair (SSIP). The fluorescence spectra of the complexes were obtained in chloroform by excitation at 270 nm to study the effect of complexation on the fluorescent properties of benzo-15-crown-5.

  7. Diaqua­(5,10,15,20-tetra­phenyl­porphyrinato-κ4 N)magnesium–18-crown-6 (1/1)

    PubMed Central

    Ezzayani, Khaireddine; Nasri, Soumaya; Belkhiria, Mohamed Salah; Daran, Jean-Claude; Nasri, Habib

    2013-01-01

    In the title compound, [Mg(C44H28N4)(H2O)2]·C12H24O6, the MgII cation lies on an inversion center and is octa­hedrally coordinated by the four N atoms of the deprotonated tetra­phenyl­porphyrin (TPP) ligand and by two water mol­ecules. The asymmetric unit contains one half of the [Mg(TPP)(H2O)2] complex and one half of an 18-crown-6 mol­ecule. The average equatorial magnesium–pyrrole N atom distance (Mg—Np) is 2.071 (1) Å and the axial Mg—O(H2O) bond length is 2.213 (1) Å. The crystal packing is stabilized by two O—H⋯O hydrogen bonds between coordinating water mol­ecules and adjacent 18-crown-6 mol­ecules, and exhibits a one-dimensional supramolecular structure along the a axis. The supramolecular architecture is futher stabilized by weak C—H⋯π inter­actions. The 18-crown-6 mol­ecule is disordered over two sets of sites with an occupancy ratio of 0.8:0.2. PMID:23424408

  8. 1,10-Phenanthroline-5,6-Dione-Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa.

    PubMed

    Granato, Marcela Queiroz; Gonçalves, Diego de Souza; Seabra, Sergio Henrique; McCann, Malachy; Devereux, Michael; Dos Santos, André Luis Souza; Kneipp, Lucimar Ferreira

    2017-01-01

    Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2](+)) and [Cu(phendione)3](ClO4)2.4H2O = ([Cu(phendione)3](2+)) on crucial physiological events of P. verrucosa conidial cells. Using the CLSI protocol, we have shown that phendione, [Ag(phendione)2](+) and [Cu(phendione)3](2+) were able to inhibit fungal proliferation, presenting MIC/IC50 values of 12.0/7.0, 4.0/2.4, and 5.0/1.8 μM, respectively. [Cu(phendione)3](2+) had fungicidal action and when combined with amphotericin B, both at sub-MIC (½ × MIC) concentrations, significantly reduced (~40%) the fungal growth. Cell morphology changes inflicted by phendione and its metal-based derivatives was corroborated by scanning electron microscopy, which revealed irreversible ultrastructural changes like surface invaginations, cell disruption and shrinkages. Furthermore, [Cu(phendione)3](2+) and [Ag(phendione)2](+) were able to inhibit metallopeptidase activity secreted by P. verrucosa conidia by approximately 85 and 40%, respectively. Ergosterol content was reduced (~50%) after the treatment of P. verrucosa conidial cells with both phendione and [Ag(phendione)2](+). To different degrees, all of the test compounds were able to disturb the P. verrucosa conidia-into-mycelia transformation. Phendione and its Ag(+) and Cu(2+) complexes may represent a promising new group of antimicrobial agents effective at inhibiting P. verrucosa growth and morphogenesis.

  9. 1,10-Phenanthroline-5,6-Dione–Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa

    PubMed Central

    Granato, Marcela Queiroz; Gonçalves, Diego de Souza; Seabra, Sergio Henrique; McCann, Malachy; Devereux, Michael; dos Santos, André Luis Souza; Kneipp, Lucimar Ferreira

    2017-01-01

    Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2]+) and [Cu(phendione)3](ClO4)2.4H2O = ([Cu(phendione)3]2+) on crucial physiological events of P. verrucosa conidial cells. Using the CLSI protocol, we have shown that phendione, [Ag(phendione)2]+ and [Cu(phendione)3]2+ were able to inhibit fungal proliferation, presenting MIC/IC50 values of 12.0/7.0, 4.0/2.4, and 5.0/1.8 μM, respectively. [Cu(phendione)3]2+ had fungicidal action and when combined with amphotericin B, both at sub-MIC (½ × MIC) concentrations, significantly reduced (~40%) the fungal growth. Cell morphology changes inflicted by phendione and its metal-based derivatives was corroborated by scanning electron microscopy, which revealed irreversible ultrastructural changes like surface invaginations, cell disruption and shrinkages. Furthermore, [Cu(phendione)3]2+ and [Ag(phendione)2]+ were able to inhibit metallopeptidase activity secreted by P. verrucosa conidia by approximately 85 and 40%, respectively. Ergosterol content was reduced (~50%) after the treatment of P. verrucosa conidial cells with both phendione and [Ag(phendione)2]+. To different degrees, all of the test compounds were able to disturb the P. verrucosa conidia-into-mycelia transformation. Phendione and its Ag+ and Cu2+ complexes may represent a promising new group of antimicrobial agents effective at inhibiting P. verrucosa growth and morphogenesis. PMID:28194139

  10. Heat transfer investigation of two Langley Research Center delta wing configurations at a Mach number of 10.5, volume 1

    NASA Technical Reports Server (NTRS)

    Eaves, R. H.; Buchanan, T. D.; Warmbrod, J. D.; Johnson, C. B.

    1972-01-01

    Heat transfer tests for two delta wing configurations were conducted in the hypervelocity wind tunnel. The 24-inch long models were tested at a Mach number of approximately 10.5 and at angles of attack of 20, 40, and 60 degrees over a length Reynolds number range from 5 million to 23 million on 4 May to 4 June 1971. Heat transfer results were obtained from model surface heat gage measurements and thermographic phosphor paint.

  11. Crystal structure of 2-[9-(2-hy-droxy-phen-yl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-deca-hydro-acridin-10-yl]acetic acid.

    PubMed

    Akkurt, Mehmet; Jasinski, Jerry P; Mohamed, Shaaban K; Allah, Omyma A Abd; Tamam, Asmaa H A; Albayati, Mustafa R

    2015-12-01

    The title compound, C21H21NO5, crystallizes with two mol-ecules in the asymmetric unit. In each mol-ecule, the central 1,4-di-hydro-pyridine ring adopts a shallow sofa conformations (with the C atom bearing the phenol ring as the flap), whereas the pendant cyclo-hexene rings both have twisted-boat conformations. Each mol-ecule features an intra-molecular O-H⋯O hydrogen bond, which closes an S(8) ring. In the crystal, the mol-ecules are linked by O-H⋯O, C-H⋯O and C-H⋯π inter-actions, forming a three-dimensional network.

  12. 10 CFR 5.520 - Job classification and structure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Job classification and structure. 5.520 Section 5.520... Education Programs or Activities Prohibited § 5.520 Job classification and structure. A recipient shall not: (a) Classify a job as being for males or for females; (b) Maintain or establish separate lines...

  13. 10 CFR 5.520 - Job classification and structure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Job classification and structure. 5.520 Section 5.520... Education Programs or Activities Prohibited § 5.520 Job classification and structure. A recipient shall not: (a) Classify a job as being for males or for females; (b) Maintain or establish separate lines...

  14. 10 CFR 5.520 - Job classification and structure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Job classification and structure. 5.520 Section 5.520... Education Programs or Activities Prohibited § 5.520 Job classification and structure. A recipient shall not: (a) Classify a job as being for males or for females; (b) Maintain or establish separate lines...

  15. 10 CFR 5.520 - Job classification and structure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Job classification and structure. 5.520 Section 5.520... Education Programs or Activities Prohibited § 5.520 Job classification and structure. A recipient shall not: (a) Classify a job as being for males or for females; (b) Maintain or establish separate lines...

  16. 10 CFR 5.520 - Job classification and structure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Job classification and structure. 5.520 Section 5.520... Education Programs or Activities Prohibited § 5.520 Job classification and structure. A recipient shall not: (a) Classify a job as being for males or for females; (b) Maintain or establish separate lines...

  17. 10 CFR 5.130 - Effect of employment opportunities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Effect of employment opportunities. 5.130 Section 5.130 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 5.130 Effect of employment...

  18. 10 CFR 13.5 - Review by the reviewing official.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Review by the reviewing official. 13.5 Section 13.5 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.5 Review by the reviewing official. (a) If, based on the report of the investigating official under § 13.4(b), the reviewing official...

  19. 10 CFR 35.5 - Maintenance of records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Maintenance of records. 35.5 Section 35.5 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.5 Maintenance of records. Each record required by this part must be legible throughout the specified retention period. The...

  20. 10 CFR 35.5 - Maintenance of records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Maintenance of records. 35.5 Section 35.5 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.5 Maintenance of records. Each record required by this part must be legible throughout the specified retention period. The...

  1. 10 CFR 35.5 - Maintenance of records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Maintenance of records. 35.5 Section 35.5 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.5 Maintenance of records. Each record required by this part must be legible throughout the specified retention period. The...

  2. 10 CFR 35.5 - Maintenance of records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Maintenance of records. 35.5 Section 35.5 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.5 Maintenance of records. Each record required by this part must be legible throughout the specified retention period. The...

  3. 10 CFR 35.5 - Maintenance of records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Maintenance of records. 35.5 Section 35.5 Energy NUCLEAR REGULATORY COMMISSION MEDICAL USE OF BYPRODUCT MATERIAL General Information § 35.5 Maintenance of records. Each record required by this part must be legible throughout the specified retention period. The...

  4. 10 CFR 15.5 - Claims that are covered.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Claims that are covered. 15.5 Section 15.5 Energy NUCLEAR REGULATORY COMMISSION DEBT COLLECTION PROCEDURES Application and Coverage § 15.5 Claims that are covered. (a... on conduct in violation of the antitrust laws; (4) A claim under the Internal Revenue Code of...

  5. Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range.

    PubMed

    Elaldi, Nazif; Yilmaz, Meral; Bagci, Binnur; Yelkovan, Izzet; Bagci, Gokhan; Gozel, Mustafa Gokhan; Engin, Aynur; Bakir, Mehmet; Dokmetas, Ilyas

    2016-07-01

    Crimean-Congo hemorrhagic fever (CCHF) is a fatal emerging acute viral infection. Not much is known regarding the pathogenic mechanisms and the reasons behind severe or mild disease courses in CCHF. IFN-alpha (IFNA) is one of the essential cytokines in the immune system. Existence of single nucleotide gene polymorphisms (SNPs) in cytokines can cause susceptibility or resistance to viral agents and different clinical courses. Hence, the relationship between SNPs in genes encoding cytokines (IFNA1 -1823G/A (rs1332190), IFNA5 -2529T/A (rs758236), IFNA10 Cys20stop (rs10119910), and IFNA17 Ile184Arg (rs9298814) SNPs and disease susceptibility were investigated. The associations between SNPs and CCHF prognosis were also studied. Total 150 patients with CCHF and 170 healthy individuals were enrolled. Genotyping was performed by PCR-RFLP methods. The frequency of IFNA1 -1823 (rs1332190) GG genotype was significantly higher in control subjects than CCHF patients (20% vs. 8%; P = 0.01). For IFNA17 Ile184Arg (rs9298814) polymorphism, CCHF patients having TG genotype had a higher frequency than the control subjects (38% vs. 32.4%; P = 0.039). The distribution of TT + TG genotype frequencies was also significantly higher in CCHF group than the controls (97.3% vs. 91.8%; P = 0.049). Genotype and allele frequencies for IFNA subtypes between fatal and survivors were the same (P > 0.05). Genotype and allele frequencies between severe and mild/moderate CCHF patients were also the same (P > 0.05). The results show that IFNA1 rs1332190 and IFNA17 rs9298814 SNPs may play an important role in CCHF susceptibility. Determining the existence of other connections for IFNA SNPs and CCHF severity and fatality requires further investigations.

  6. 10 CFR 960.5-2-5 - Environmental quality.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., technical, social, economic, and environmental factors; and (2) the requirements specified in § 960.5-1(a)(2... programmatic, technical, social, economic, and environmental factors. (2) Any part of the restricted area or... of reasonable measures, taking into account programmatic, technical, social, economic,...

  7. 10 CFR 960.5-2-5 - Environmental quality.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., technical, social, economic, and environmental factors; and (2) the requirements specified in § 960.5-1(a)(2... programmatic, technical, social, economic, and environmental factors. (2) Any part of the restricted area or... of reasonable measures, taking into account programmatic, technical, social, economic,...

  8. 10 CFR 960.5-2-5 - Environmental quality.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., technical, social, economic, and environmental factors; and (2) the requirements specified in § 960.5-1(a)(2... programmatic, technical, social, economic, and environmental factors. (2) Any part of the restricted area or... of reasonable measures, taking into account programmatic, technical, social, economic,...

  9. 10 CFR 960.5-2-5 - Environmental quality.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., technical, social, economic, and environmental factors; and (2) the requirements specified in § 960.5-1(a)(2... programmatic, technical, social, economic, and environmental factors. (2) Any part of the restricted area or... of reasonable measures, taking into account programmatic, technical, social, economic,...

  10. 10 CFR 960.5-2-5 - Environmental quality.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., technical, social, economic, and environmental factors; and (2) the requirements specified in § 960.5-1(a)(2... programmatic, technical, social, economic, and environmental factors. (2) Any part of the restricted area or... of reasonable measures, taking into account programmatic, technical, social, economic,...

  11. Validation of 3D-CMCC Forest Ecosystem Model (v.5.1) against eddy covariance data for 10 European forest sites

    NASA Astrophysics Data System (ADS)

    Collalti, A.; Marconi, S.; Ibrom, A.; Trotta, C.; Anav, A.; D'Andrea, E.; Matteucci, G.; Montagnani, L.; Gielen, B.; Mammarella, I.; Grünwald, T.; Knohl, A.; Berninger, F.; Zhao, Y.; Valentini, R.; Santini, M.

    2016-02-01

    This study evaluates the performances of the new version (v.5.1) of 3D-CMCC Forest Ecosystem Model (FEM) in simulating gross primary productivity (GPP), against eddy covariance GPP data for 10 FLUXNET forest sites across Europe. A new carbon allocation module, coupled with new both phenological and autotrophic respiration schemes, was implemented in this new daily version. Model ability in reproducing timing and magnitude of daily and monthly GPP fluctuations is validated at intra-annual and inter-annual scale, including extreme anomalous seasons. With the purpose to test the 3D-CMCC FEM applicability over Europe without a site-related calibration, the model has been deliberately parametrized with a single set of species-specific parametrizations for each forest ecosystem. The model consistently reproduces both in timing and in magnitude daily and monthly GPP variability across all sites, with the exception of the two Mediterranean sites. We find that 3D-CMCC FEM tends to better simulate the timing of inter-annual anomalies than their magnitude within measurements' uncertainty. In six of eight sites where data are available, the model well reproduces the 2003 summer drought event. Finally, for three sites we evaluate whether a more accurate representation of forest structural characteristics (i.e. cohorts, forest layers) and species composition can improve model results. In two of the three sites results reveal that model slightly increases its performances although, statistically speaking, not in a relevant way.

  12. Scoping design analyses for optimized shipping casks containing 1-, 2-, 3-, 5-, 7-, or 10-year-old PWR spent fuel

    SciTech Connect

    Bucholz, J.A.

    1983-01-01

    This report details many of the interrelated considerations involved in optimizing large Pb, Fe, or U-metal spent fuel shipping casks containing 1, 2, 3, 5, 7, or 10-year-old PWR fuel assemblies. Scoping analyses based on criticality, shielding, and heat transfer considerations indicate that some casks may be able to hold as many as 18 to 21 ten-year-old PWR fuel assemblies. In the criticality section, a new type of inherently subcritical fuel assembly separator is described which uses hollow, borated stainless-steel tubes in the wall-forming structure between the assemblies. In another section, details of many n/..gamma.. shielding optimization studies are presented, including the optimal n/..gamma.. design points and the actual shielding requirements for each type of cask as a function of the age of the spent fuel and the number of assemblies in the cask. Multigroup source terms based on ORIGEN2 calculations at these and other decay times are also included. Lastly, the numerical methods and experimental correlations used in the steady-state and transient heat transfer analyses are fully documented, as are pertinent aspects of the SCOPE code for Shipping Cask Optimization and Parametric Evaluation. (While only casks for square, intact PWR fuel assemblies were considered in this study, the SCOPE code may also be used to design and analyze casks containing canistered spent fuel or other waste material. An abbreviated input data guide is included as an appendix).

  13. On the physics of the bimodal coherent dynamics of the turbulent horseshoe vortex at Re=1.16x10^5

    NASA Astrophysics Data System (ADS)

    Paik, Joongcheol; Escauriaza, Cristian; Sotiropoulos, Fotis

    2006-11-01

    Due to the strong adverse pressure gradients, the boundary layer approaching a wall-mounted obstacle undergoes a three-dimensional separation with horseshoe vortices which wrap around the obstacle like necklace. Devenport and Simpson (J Fluid Mech., Vol. 210, P. 23 1990) reported the large scale unsteady bimodal nature of the horseshoe vortex system in the leading edge region of a wing at Re=1.16x10^5 which switches aperiodically from one mode to another at time intervals and accounts for turbulent energy production and turbulent stresses an order of magnitude higher than those from conventional shear mechanism in the upstream boundary layer. We carried out detached eddy simulations of the flow past a wing experimentally investigated by Devenport and Simpson and for the first time numerically confirmed the experimental finding of the bimodal velocity probability phenomenon in the horseshoe vortex region. Detailed quantitative comparisons with the measurements and analysis of the 3D nature of large scale coherent vortical structures in the wing-body junction flow will be present in the presentation.

  14. Thermoeconomic modeling and parametric study of hybrid SOFC-gas turbine-steam turbine power plants ranging from 1.5 to 10 MWe

    NASA Astrophysics Data System (ADS)

    Arsalis, Alexandros

    Detailed thermodynamic, kinetic, geometric, and cost models are developed, implemented, and validated for the synthesis/design and operational analysis of hybrid SOFC-gas turbine-steam turbine systems ranging in size from 1.5 to 10 MWe. The fuel cell model used in this research work is based on a tubular Siemens-Westinghouse-type SOFC, which is integrated with a gas turbine and a heat recovery steam generator (HRSG) integrated in turn with a steam turbine cycle. The current work considers the possible benefits of using the exhaust gases in a HRSG in order to produce steam which drives a steam turbine for additional power output. Four different steam turbine cycles are considered in this research work: a single-pressure, a dual-pressure, a triple pressure, and a triple pressure with reheat. The models have been developed to function both at design (full load) and off-design (partial load) conditions. In addition, different solid oxide fuel cell sizes are examined to assure a proper selection of SOFC size based on efficiency or cost. The thermoeconomic analysis includes cost functions developed specifically for the different system and component sizes (capacities) analyzed. A parametric study is used to determine the most viable system/component syntheses/designs based on maximizing total system efficiency or minimizing total system life cycle cost.

  15. Straight and chopped dc performance data for a General Electric 5BT 2366C10 motor and an EV-1 controller

    NASA Technical Reports Server (NTRS)

    Edie, P. C.

    1981-01-01

    Performance data on the General Electric 5BT 2366C10 series wound dc motor and EV-1 Chopper Controller is supplied for the electric vehicle manufacturer. Data is provided for both straight and chopped dc input to the motor, at 2 motor temperature levels. Testing was done at 6 voltage increments to the motor, and 2 voltage increments to the controller. Data results are presented in both tabular and graphical forms. Tabular information includes motor voltage and current input data, motor speed and torque output data, power data and temperature data. Graphical information includes torque-speed, motor power output-speed, torque-current, and efficiency-speed plots under the various operating conditions. The data resulting from this testing shows the speed-torque plots to have the most variance with operating temperature. The maximum motor efficiency is between 86% and 87%, regardless of temperature or mode of operation. When the chopper is utilized, maximum motor efficiency occurs when the chopper duty cycle approaches 100%.

  16. Lower critical field and intragrain critical current density in the ruthenate-cuprate RuSr2Gd1.5Ce0.5Cu2O10

    NASA Astrophysics Data System (ADS)

    Das Virgens, M. G.; Garcia, S.; Ghivelder, L.

    2006-01-01

    The lower critical field of the grains, Hc1, and the intragrain critical current density, Jc, were determined for the superconducting ruthenate-cuprate RuSr2Gd1.5Ce0.5Cu2O10-δ [Ru-1222(Gd)] through a systematic study of the hysteresis in magnetoresistance loops. A reliable method, based on the effects of the magnetization of the grains on the net local field at the intergranular junctions is provided, circumventing the problem of the strong masking of the superconducting diamagnetic signal by the ferromagnetic background. The temperature dependency of Hc1 and Jc both exhibit a smooth increase on cooling without saturation down to T/T_{SC} \\cong 0.2. The obtained Hc1 values vary between 150 and 1500 Oe in the 0.2 ≤ T/TSC ≤0.4 interval, for samples annealed in an oxygen flow; oxygenation under high pressure (50 atm) leads to a further increase. These values are much larger than the previously reported rough assessments (25 50 Oe), using conventional magnetization measurements. High Jc values of 107 A/cm2, comparable to the high-Tc cuprates, were obtained. The Hc1(T) and Jc(T) dependencies are explained in the context of a magnetic phase separation scenario.

  17. Syntheses, crystal structures, and luminescence of two lanthanide coordination polymers based on 5-(3‧,4‧-bis(tetrazol-5″-yl)phenoxy)isophthalic acid and 1,10-phenanthroline

    NASA Astrophysics Data System (ADS)

    Chen, Xiaoli; Li, Congcong; Ai, Fengfeng; Qu, Xu; Liu, Kang

    2017-04-01

    Two new lanthanide coordination polymers, [Ln(btpa)(phen)2(OH)]n·nH2O (Ln= Tb 1, Pr 2) (H2btpa=5-(3‧,4‧-bis(tetrazol-5″-yl)phenoxy)isophthalic acid, phen=1,10-phenanthroline), have been successfully synthesized and structurally characterized by elemental analyses, IR spectroscopy, single-crystal X-ray diffraction, TGA and powder X-ray diffraction analyses. Coordination polymers 1-2 are isomorphism structures, showing a 1D chain bearing hooks structure. LnⅢ ion in 1-2 adopt nine-coordinated mode to construct a tricapped trigonal prism configuration. The adjacent chains form a 2D supramolecular network via π … π stacking interactions between the pyridine rings of phen ligands. Then the neighbouring 2D supramolecular networks recognizing each other form a 3D supramolecular structure through π … π interaction between benzene rings of (btpa)2- ligands. The luminescence experiments show that TbIII complex exhibits typical metal-centered emissions in the visible region in the solid state.

  18. A 0.06 mm2 1.0 V 2.5 mW 10 bit 250 MS/s current-steering D/A converter in 65 nm GP CMOS process

    NASA Astrophysics Data System (ADS)

    Yawei, Guo; Li, Li; Peng, Ou; Zhida, Hui; Xu, Cheng; Xiaoyang, Zeng

    2014-06-01

    A 10 bit 250 MS/s current-steering digital-to-analog converter is presented. Only standard VT core devices are available for the sake of simplicity and low cost. In order to meet the INL performance, a Monte Carlo model is built to analyze the impact of mismatch on integral nonlinearity (INL) yield with both end-point line and best-fit line. A formula is derived for the relationship of INL and output impedance. The relation of dynamic range and output impedance is also discussed. The double centroid layout is adopted for the current source array in order to mitigate the effect of electrical, process, and temperature gradient. An adapted current mirror is used to overcome the gate leakage of the current source array, which cannot be ignored in the 65 nm GP CMOS process. The digital-to-analog converter occupies 0.06 mm2, and consumes 2.5 mW from a single 1.0 V supply at 250 MS/s.

  19. 45 CFR 5.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose. 5.1 Section 5.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.1 Purpose. This part contains the rules that the Department of Health and Human Services (HHS) follows in handling requests for records under...

  20. 45 CFR 5b.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Definitions. 5b.1 Section 5b.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.1 Definitions. As used in this part: (a) Access means availability of a record to a subject individual. (b) Agency means the Department of Health and...

  1. Peroxisomal Ubiquitin-Protein Ligases Peroxin2 and Peroxin10 Have Distinct But Synergistic Roles in Matrix Protein Import and Peroxin5 Retrotranslocation in Arabidopsis1[W][OPEN

    PubMed Central

    Burkhart, Sarah E.; Kao, Yun-Ting; Bartel, Bonnie

    2014-01-01

    Peroxisomal matrix proteins carry peroxisomal targeting signals (PTSs), PTS1 or PTS2, and are imported into the organelle with the assistance of peroxin (PEX) proteins. From a microscopy-based screen to identify Arabidopsis (Arabidopsis thaliana) mutants defective in matrix protein degradation, we isolated unique mutations in PEX2 and PEX10, which encode ubiquitin-protein ligases anchored in the peroxisomal membrane. In yeast (Saccharomyces cerevisiae), PEX2, PEX10, and a third ligase, PEX12, ubiquitinate a peroxisome matrix protein receptor, PEX5, allowing the PEX1 and PEX6 ATP-hydrolyzing enzymes to retrotranslocate PEX5 out of the membrane after cargo delivery. We found that the pex2-1 and pex10-2 Arabidopsis mutants exhibited defects in peroxisomal physiology and matrix protein import. Moreover, the pex2-1 pex10-2 double mutant exhibited severely impaired growth and synergistic physiological defects, suggesting that PEX2 and PEX10 function cooperatively in the wild type. The pex2-1 lesion restored the unusually low PEX5 levels in the pex6-1 mutant, implicating PEX2 in PEX5 degradation when retrotranslocation is impaired. PEX5 overexpression altered pex10-2 but not pex2-1 defects, suggesting that PEX10 facilitates PEX5 retrotranslocation from the peroxisomal membrane. Although the pex2-1 pex10-2 double mutant displayed severe import defects of both PTS1 and PTS2 proteins into peroxisomes, both pex2-1 and pex10-2 single mutants exhibited clear import defects of PTS1 proteins but apparently normal PTS2 import. A similar PTS1-specific pattern was observed in the pex4-1 ubiquitin-conjugating enzyme mutant. Our results indicate that Arabidopsis PEX2 and PEX10 cooperate to support import of matrix proteins into plant peroxisomes and suggest that some PTS2 import can still occur when PEX5 retrotranslocation is slowed. PMID:25214533

  2. A Ru(II) complex with 2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: synthesis, characterization, and acid-base and DNA-binding properties.

    PubMed

    Gao, Jie; Wang, Zhi-Ping; Yuan, Cui-Li; Jia, Hai-Shun; Wang, Ke-Zhi

    2011-09-01

    A new Ru(II) complex of [Ru(bpy)2(Hmspip)]Cl2 {in which bpy=2,2'-bipyridine, Hmspip=2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline} have been synthesized and characterized. The ground- and excited-state acid-base properties of [Ru(bpy)2(Hmspip)]Cl2 and its parent complex of [Ru(bpy)2(Hpip)]Cl2 {Hpip=2-phenyl-1H-imidazo[4,5-f][1,10]phenanthroline} have been studied by UV-visible (UV-vis) and emission spectrophotometric pH titrations. [Ru(bpy)2(Hmspip)]Cl2 acts as a calf thymus DNA intercalators with a binding constant of 4.0×10(5) M(-1) in buffered 50 mM NaCl, as evidenced by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN)6]4-, DNA competitive binding with ethidium bromide, reverse salt titrations and viscosity measurements.

  3. CCAIN, Version 1.0

    SciTech Connect

    Rickett, Christopher D.; Rasmussen, Craig E.; Sottile, Matthew J.

    2005-05-26

    CCAIN, Version 1.0 Date: 06/15/2005 This software is an instantiation of Common Component Architecture (CCA) framework written in C. The framework is used to compose (create, register, destroy) C, C++, and Fortran components into a running CCA application. Language bindings are provided for F90 and F03 to allow codes in these languages to interface with the framework.

  4. Water soluble aerosols and gases at a UK background site - Part 1: Controls of PM2.5 and PM10 aerosol composition

    NASA Astrophysics Data System (ADS)

    Twigg, M. M.; Di Marco, C. F.; Leeson, S.; van Dijk, N.; Jones, M. R.; Leith, I. D.; Morrison, E.; Coyle, M.; Proost, R.; Peeters, A. N. M.; Lemon, E.; Frelink, T.; Braban, C. F.; Nemitz, E.; Cape, J. N.

    2015-07-01

    There is limited availability of long-term, high temporal resolution, chemically speciated aerosol measurements which can provide further insight into the health and environmental impacts of particulate matter. The Monitor for AeRosols and Gases (MARGA, Applikon B.V., NL) allows for the characterisation of the inorganic components of PM10 and PM2.5 (NH4+, NO3-, SO42-, Cl-, Na+, K+, Ca2+, Mg2+) and inorganic reactive gases (NH3, SO2, HCl, HONO and HNO3) at hourly resolution. The following study presents 6.5 years (June 2006 to December 2012) of quasi-continuous observations of PM2.5 and PM10 using the MARGA at the UK EMEP supersite, Auchencorth Moss, SE Scotland. Auchencorth Moss was found to be representative of a remote European site with average total water soluble inorganic mass of PM2.5 of 3.82 μg m-3. Anthropogenically derived secondary inorganic aerosols (sum of NH4+, NO3- and nss-SO42-) were the dominating species (63 %) of PM2.5. In terms of equivalent concentrations, NH4+ provided the single largest contribution to PM2.5 fraction in all seasons. Sea salt was the main component (73 %) of the PMcoarse fraction (PM10-PM2.5), though NO3- was also found to make a relatively large contribution to the measured mass (17 %) providing evidence of considerable processing of sea salt in the coarse mode. There was on occasions evidence of aerosol from combustion events being transported to the site in 2012 as high K+ concentrations (deviating from the known ratio in sea salt) coincided with increases in black carbon at the site. Pollution events in PM10 (defined as concentrations > 12 μg m-3) were on average dominated by NH4+ and NO3-, where smaller loadings at the site tended to be dominated by sea salt. As with other western European sites, the charge balance of the inorganic components resolved were biased towards cations, suggesting the aerosol was basic or more likely that organic acids contributed to the charge balance. This study demonstrates the UK

  5. Water soluble aerosols and gases at a UK background site - Part 1: Controls of PM2.5 and PM10 aerosol composition

    NASA Astrophysics Data System (ADS)

    Twigg, M. M.; Di Marco, C. F.; Leeson, S.; van Dijk, N.; Jones, M. R.; Leith, I. D.; Morrison, E.; Coyle, M.; Proost, R.; Peeters, A. N. M.; Lemon, E.; Frelink, T.; Braban, C. F.; Nemitz, E.; Cape, J. N.

    2015-02-01

    There is limited availability of long-term, high temporal resolution, chemically speciated aerosol measurements, which can lead to further insight into the health and environmental impacts of particulate matter. The Monitor for AeRosols and Gases (MARGA, Applikon B.V., NL) allows characterisation of the inorganic components of PM10 and PM2.5 (NH4+, NO3-, SO42-, Cl-, Na+, K+, Ca2+, Mg2+) and inorganic reactive gases (NH3, SO2, HCl, HONO and HNO3) at hourly resolution. The following study presents 6.5 years (June 2006 to December 2012) of quasi-continuous observations of PM2.5 and PM10 using the MARGA at the UK EMEP "Supersite", Auchencorth Moss, SE Scotland. Auchencorth Moss was found to be representative of a remote European site with average total water soluble inorganic mass of PM2.5 of 3.82 μg m-3. Anthropogenically derived secondary inorganic aerosols (sum of NH4+, NO3- and nss-SO42-), were the dominating species (63%) of PM2.5. In terms of equivalent concentrations, NH4+ provided the single largest contribution to PM2.5 fraction in all seasons. Sea salt, was the main component (73%) of the PMcoarse fraction (PM10-PM2.5), though NO3- was also found to make a relatively large contribution to the measured mass (17%) as providing evidence of considerable processing of sea salt in the coarse mode. There was on occasions evidence of aerosol from combustion events being transported to the site in 2012 as high K+ concentrations (deviating from the known ratio in sea salt) coincided with increases in black carbon at the site. Pollution events in PM10 (defined as concentrations > 12 μg m-3) were on average dominated by NH4+ and NO3-, where as smaller loadings at the site tended to be dominated by sea salt. As with other Western European sites, the charge balance of the inorganic components resolved were biased towards cations, suggesting the aerosol was basic or more likely, that organic acids contributed to the charge

  6. AKARI observations of brown dwarfs. IV. Effect of elemental abundances on near-infrared spectra between 1.0 and 5.0 μm

    SciTech Connect

    Sorahana, S.; Yamamura, I.

    2014-09-20

    The detection of the CO{sub 2} absorption band at 4.2 μm in brown dwarf spectra by AKARI has made it possible to discuss CO{sub 2} molecular abundance in brown dwarf atmospheres. In our previous studies, we found an excess in the 4.2 μm CO{sub 2} absorption band of three brown dwarf spectra, and suggested that these deviations were caused by high C and O elemental abundances in their atmospheres. To validate this hypothesis, we have constructed a set of models of brown dwarf atmospheres with various elemental abundance patterns, and we investigate the variations of the molecular composition and the thermal structure, and how they affect the near-infrared spectra between 1.0 and 5.0 μm. The 4.2 μm CO{sub 2} absorption band in some late-L and T dwarfs taken by AKARI is stronger or weaker than predicted by corresponding models with solar abundance. By comparing the CO{sub 2} band in the model spectra to the observed near-infrared spectra, we confirm possible elemental abundance variations among brown dwarfs. We find that the band strength is especially sensitive to O abundance, but C is also needed to reproduce the entire near-infrared spectra. This result indicates that both the C and O abundances should increase and decrease simultaneously for brown dwarfs. We find that a weaker CO{sub 2} absorption band in a spectrum can also be explained by a model with lower 'C and O' abundances.

  7. Stereochemistry of LinB-catalyzed biotransformation of δ-HBCD to 1R,2R,5S,6R,9R,10S-pentabromocyclododecanol.

    PubMed

    Heeb, Norbert V; Zindel, Daniel; Graf, Heidi; Azara, Valeria; Schweizer, W Bernd; Geueke, Birgit; Kohler, Hans-Peter E; Lienemann, Peter

    2013-02-01

    The haloalkane dehalogenase LinB from Sphingobium indicum B90A converts β-hexachlorocyclohexane (β-HCH), the most persistent HCH stereoisomer, to mono- and dihydroxylated metabolites. Recently, we reported that LinB also transforms α-, β- and γ-hexabromocyclododecanes (HBCDs), which are structurally related to HCHs. Here, we show that LinB catalyzes the hydroxylation of δ-HBCD to two pentabromocyclododecanols (PBCDOHs) and two tetrabromocyclododecadiols (TBCDDOHs). The stereochemistry of this enzymatic transformation was deduced from XRD crystal structure data of the substrate δ-HBCD and α(2)-PBCDOH, one of the biotransformation products. Five stereocenters of δ-HBCD are unchanged but the one at C6 is converted to an alcohol with inversion from S- to R-configuration in a nucleophilic, S(N)2-like substitution reaction. Only α(2)-PBCDOH with the 1R,2R,5S,6R,9R,10S-configuration is obtained but not its enantiomer. With only two of the 64 PBCDOHs formed, these transformations indeed are regio- and stereoselective. A conformational analysis revealed that the triple-turn motive, which is predominant in δ-HBCD and in several other HBCD stereoisomers, is also found in the product. This shows that LinB preferentially converted reactive bromine atoms but not those in the conserved triple-turn motive. The widespread contamination with HCHs triggered the bacterial evolution of dehalogenases which acquired the ability to convert these pollutants and their metabolites. We here demonstrate that LinB of S. indicum also transforms HBCDs regio- and stereoselectively following a similar mechanism.

  8. Optimal Path Analyzer (Version 1.0)

    DTIC Science & Technology

    1989-10-01

    ABSTRACT (Continue on reverse if necessary and identify by block number) This report describes the function, operation, test and evaluation results of the...14 Technical Description ........................................ 14 Test and Evaluation .......................................... 16...Neural Network .................................. 10 5. Output Iteration Test Results ........................... 19 6. OPA 1.0 Sample Run B3 - S3

  9. Syntheses and crystal structures of new chain-containing iodometallate compounds: [H1,10-phen](H 2O) 1.41[AgI 2], [H1,10-phen](H 2O) 1.42[CuI 2]; [Co(tpy) 2][Bi 2I 8], [Fe(tpy) 2][Bi 2I 8]; [Co(1,10-phen) 3][Pb 3I 8]·H 2O, and [Fe(1,10-phen) 3][Pb 3I 8]·0.5(H 2O)

    NASA Astrophysics Data System (ADS)

    Tershansy, Meredith A.; Goforth, Andrea M.; Peterson, LeRoy; Burns, M. C.; Smith, Mark D.; zur Loye, Hans-Conrad

    2007-10-01

    Three pairs of novel, isostructural polymeric iodometallate compounds, [H1,10-phen](H 2O) 1.41[AgI 2] ( 1) ([H1,10-phen] + = [1,10-phenanthrolinium] +), [H1,10-phen](H 2O) 1.42[CuI 2] ( 2), [Co(tpy) 2][Bi 2I 8] ( 3) (tpy = 2,2':6'2″-terpyridine), [Fe(tpy) 2][Bi 2I 8] ( 4), [Co(1,10-phen) 3][Pb 3I 8]·H 2O ( 5) (1,10-phen = 1,10-phenanthroline), and [Fe(1,10-phen) 3][Pb 3I 8]·0.5(H 2O) ( 6) have been synthesized solvothermally and characterized by single crystal X-ray diffraction. Compounds 1 and 2 are isostructural and crystallize in the orthorhombic space group Cmma with lattice parameters of a = 6.7063(7) Å, b = 17.6051(18) Å, c = 12.7088(13) Å and a = 6.5770(3) Å, b = 17.5245(8) Å, c = 12.5515(6) Å, respectively. The polymeric anionic chains in 1 and 2 are formed by edge-sharing MI 4 (M = Ag, Cu) tetrahedra. Compounds 3 and 4 are isostructural and crystallize in the monoclinic space group P2 1/ n with lattice parameters of a = 16.5085(7) Å, b = 16.0392(7) Å, c = 16.5115(7) Å, β = 97.4710(10)° and a = 16.4478(6) Å, b = 16.0645(6) Å, c = 16.4498(6) Å, β = 97.4490(10)°, respectively. Both structures contain the first observed, face-sharing [Bi 2I 8] 2- anion cluster that is linked via corner sharing into infinite zig-zag anionic chains. Compounds 5 and 6 are isostructural and crystallize in the triclinic space group P1¯ with lattice parameters of a = 11.8798(5) Å, b = 15.2805(7) Å, c = 16.1889(7) Å, α = 63.9240(10)°, β = 74.0420(10)°, γ = 73.2540(10)° and a = 11.7889(5) Å, b = 15.3224(6) Å, c = 16.2584(6) Å, α = 64.1920(10)°, β = 73.5600(10)°, and γ = 73.7120(10)°, respectively. Compounds 5 and 6 contain infinite [Pb 3I 8] 2- chains in which the three crystallographically unique Pb 2+ ions are found in sets of three trans face-sharing octahedra. These face-sharing trimers are observed in pairs that share three edges, and the pairs are further connected into 1-D chains by edge sharing with neighboring 2 × 3 units.

  10. 10 CFR 960.5-2-6 - Socioeconomic impacts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... impacts. (a) Qualifying condition. The site shall be located such that (1) any significant adverse social and/or economic impacts induced in communities and surrounding regions by repository siting... 10 Energy 4 2012-01-01 2012-01-01 false Socioeconomic impacts. 960.5-2-6 Section 960.5-2-6...

  11. 10 CFR 960.5-2-6 - Socioeconomic impacts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... impacts. (a) Qualifying condition. The site shall be located such that (1) any significant adverse social and/or economic impacts induced in communities and surrounding regions by repository siting... 10 Energy 4 2014-01-01 2014-01-01 false Socioeconomic impacts. 960.5-2-6 Section 960.5-2-6...

  12. 10 CFR 960.5-2-6 - Socioeconomic impacts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... impacts. (a) Qualifying condition. The site shall be located such that (1) any significant adverse social and/or economic impacts induced in communities and surrounding regions by repository siting... 10 Energy 4 2013-01-01 2013-01-01 false Socioeconomic impacts. 960.5-2-6 Section 960.5-2-6...

  13. 10 CFR 960.5-2-6 - Socioeconomic impacts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... impacts. (a) Qualifying condition. The site shall be located such that (1) any significant adverse social and/or economic impacts induced in communities and surrounding regions by repository siting... 10 Energy 4 2011-01-01 2011-01-01 false Socioeconomic impacts. 960.5-2-6 Section 960.5-2-6...

  14. 10 CFR 5.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Preference in admission. 5.305 Section 5.305 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and...

  15. 10 CFR 960.5-2-6 - Socioeconomic impacts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Socioeconomic impacts. 960.5-2-6 Section 960.5-2-6 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE... sectors of the economy of the affected area. (c) Potentially adverse conditions. (1) Potential...

  16. 10 CFR 5.400 - Education programs or activities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Education programs or activities. 5.400 Section 5.400 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs...

  17. 10 CFR 5.400 - Education programs or activities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Education programs or activities. 5.400 Section 5.400 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs...

  18. 10 CFR 5.400 - Education programs or activities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Education programs or activities. 5.400 Section 5.400 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs...

  19. 10 CFR 5.400 - Education programs or activities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Education programs or activities. 5.400 Section 5.400 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs...

  20. 10 CFR 5.400 - Education programs or activities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Education programs or activities. 5.400 Section 5.400 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs...