Science.gov

Sample records for 1-3 km wide

  1. Seismic evidence for a wide-spread low velocity layer atop the 410-km discontinuity

    NASA Astrophysics Data System (ADS)

    Tauzin, B.; Debayle, E.; Wittlinger, G.

    2009-12-01

    The origin of a low seismic-velocity layer observed in a few regions in the world atop the upper boundary of the mantle transition zone (the 410-km seismic discontinuity) is debated. It has been attributed to the dehydration of subductions, the dehydration of water-bearing silicate beneath continental platforms in the vicinity of mantle plumes, or to dehydration-induced partial melting of ascending ambient mantle rising out of a high-water-solubility transition zone. These interpretations suggest the effect of water which reduces the solidus of mantle silicate rocks and favors partial melting. We present global multiple frequency observations of P-to-S receiver functions indicating that this low velocity layer is actually a wide-spread feature of the upper mantle. Its location is uncorrelated with any tectonic or geodynamic environment. The estimated layer thickness varies over short lateral wavelengths (~200 km) in a range 30 to 100 km. This complexity suggests a compositional origin with a lens-type lateral extension. Dehydration in the vicinity of subductions or mantle plumes cannot solely explain the observed layer implantation. (A) Synthetic receiver functions (RFs) obtained at four lower corner periods for different thicknesses of a low velocity layer (LVL) atop the "410". Steep downward increases of seismic velocities (e.g. the "410") show up as positive (white) amplitudes on the RFs. Steep downward velocity decreases (e.g. the top of the LVL) show up as negative (black) amplitudes. (B) Multiple-frequency RFs obtained at 42 seismic stations after alignment on the "410" waveform. The "410" waveform has a positive amplitude and is colored in white. Under these stations, the top of a LVL is visible. It shows up as a negative (black) amplitude and is emphasized with the small white crosses. The RFs have been ordered by increasing LVL thickness. (C) Synthetic RFs computed using the same LVL thickness distribution as observed on the data.

  2. Genome-wide characterization of the β-1,3-glucanase gene family in Gossypium by comparative analysis

    PubMed Central

    Xu, Xiaoyang; Feng, Yue; Fang, Shuai; Xu, Jun; Wang, Xinyu; Guo, Wangzhen

    2016-01-01

    The β-1,3-glucanase gene family is involved in a wide range of plant developmental processes as well as pathogen defense mechanisms. Comprehensive analyses of β-1,3-glucanase genes (GLUs) have not been reported in cotton. Here, we identified 67, 68, 130 and 158 GLUs in four sequenced cotton species, G. raimondii (D5), G. arboreum (A2), G. hirsutum acc. TM-1 (AD1), and G. barbadense acc. 3–79 (AD2), respectively. Cotton GLUs can be classified into the eight subfamilies (A–H), and their protein domain architecture and intron/exon structure are relatively conserved within each subfamily. Sixty-seven GLUs in G. raimondii were anchored onto 13 chromosomes, with 27 genes involved in segmental duplications, and 13 in tandem duplications. Expression patterns showed highly developmental and spatial regulation of GLUs in TM-1. In particular, the expression of individual member of GLUs in subfamily E was limited to roots, leaves, floral organs or fibers. Members of subfamily E also showed more protein evolution and subgenome expression bias compared with members of other subfamilies. We clarified that GLU42 and GLU43 in subfamily E were preferentially expressed in root and leaf tissues and significantly upregulated after Verticillium dahliae inoculation. Silencing of GLU42 and GLU43 significantly increased the susceptibility of cotton to V. dahliae. PMID:27353015

  3. Tris(1,3-dichloro-2-propyl)phosphate Induces Genome-Wide Hypomethylation within Early Zebrafish Embryos

    PubMed Central

    2016-01-01

    Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is a high-production volume organophosphate-based plasticizer and flame retardant widely used within the United States. Using zebrafish as a model, the objectives of this study were to determine whether (1) TDCIPP inhibits DNA methyltransferase (DNMT) within embryonic nuclear extracts; (2) uptake of TDCIPP from 0.75 h postfertilization (hpf, 2-cell) to 2 hpf (64-cell) or 6 hpf (shield stage) leads to impacts on the early embryonic DNA methylome; and (3) TDCIPP-induced impacts on cytosine methylation are localized to CpG islands within intergenic regions. Within this study, 5-azacytidine (5-azaC, a DNMT inhibitor) was used as a positive control. Although 5-azaC significantly inhibited zebrafish DNMT, TDCIPP did not affect DNMT activity in vitro at concentrations as high as 500 μM. However, rapid embryonic uptake of 5-azaC and TDCIPP from 0.75 to 2 hpf resulted in chemical- and chromosome-specific alterations in cytosine methylation at 2 hpf. Moreover, TDCIPP exposure predominantly resulted in hypomethylation of positions outside of CpG islands and within intragenic (exon) regions of the zebrafish genome. Overall, these findings provide the foundation for monitoring DNA methylation dynamics within zebrafish as well as identifying potential associations among TDCIPP exposure, adverse health outcomes, and DNA methylation status within human populations. PMID:27574916

  4. Proteomic Analysis of Tissue from α1,3-galactosyltransferase Knockout Mice Reveals That a Wide Variety of Proteins and Protein Fragments Change Expression Level

    PubMed Central

    Thorlacius-Ussing, Louise; Ludvigsen, Maja; Kirkeby, Svend

    2013-01-01

    A barrier in a pig-to-man xenotransplantation is that the Galα1-3Galβ1-4GlcNAc-R carbohydrate (α-Gal epitope) expressed on pig endothelial cells reacts with naturally occurring antibodies in the recipient’s blood leading to rejection. Deletion of the α1,3-galactosyltransferase gene prevents the synthesis of the α-Gal epitope. Therefore, knockout models of the α1,3-galactosyltransferase gene are widely used to study xenotransplantation. We have performed proteomic studies on liver and pancreas tissues from wild type and α1,3-galactosyltransferase gene knockout mice. The tissues were analyzed by two-dimensional polyacrylamide gel electrophoresis and liquid chromatography - tandem mass spectrometry. The analyses revealed that a wide variety of proteins and protein fragments are differentially expressed suggesting that knockout of the α1,3-galactosyltransferase gene affects the expression of several other genes. PMID:24244699

  5. Detection of the 158 Micrometers[CII] Transition at z=1.3: Evidence for a Galaxy-Wide Starburst

    NASA Technical Reports Server (NTRS)

    Hailey-Dunsheath, S.; Nikola, T.; Oberst, T. E.; Parshley, S. C.; Benford, D. J.; Staguhn, J. G.; Tucker, C. E.

    2010-01-01

    We report the detection of 158 micron [C II] fine-structure line emission from MIPS J142824.0+352619, a hyperluminous ( L(sub IR) approximates 10(exp 13) L (sub solar)) starburst galaxy at z = 1.3. The line is bright, corresponding to a fraction L(sub [Cu II] L(sub Fir) approximates 2 x 10(exp -3) of the far-IR (FIR) continuum. The [C II], CO, and FIR continuum emission may be modeled as arising from photodissociation regions (PDRs) that have a characteristic gas density of n approximates 10(exp 4.2) /cm(exp 3) , and that are illuminated by a far-UV radiation field approximately 10(exp 3.2) times more intense than the local interstellar radiation field. The mass in these PDRs accounts for approximately half of the molecular gas mass in this galaxy. The L(sub [CII])/L(sub FIR) ratio is higher than observed in local ultralummous infrared galaxies or in the few high-redshift QSOs detected in [C II], but the L(sub [CII])/L(sub FIR) and L(sub CO)/L(sub FIR) ratios are similar to the values seen in nearby starburst galaxies. This suggests that MIPS J142824.0+352619 is a scaled-up version of a starburst nucleus, with the burst extended over several kiloparsecs.

  6. Detection of the 158 Micrometers[CII] Transition at z=1.3: Evidence for a Galaxy-Wide Starburst

    NASA Technical Reports Server (NTRS)

    Hailey-Dunsheath, S.; Nikola, T.; Stacey, G. J.; Oberst, T. E.; Parshley, S. C.; Benford, D. J.; Staguhn, J. G.; Tucker, C. E.

    2010-01-01

    We report the detection of 158 micrometer [C II] fine-structure line emission from MIPS J 142824.0+3526l9, a hyperluminous (L(sub IR) approx. 10(exp 13) Solar Luminosity starburst galaxy at z = 1.3. The line is bright, corresponding to a fraction L[C II]/L(sub FIR) approx. equals 2 x l0(exp -3) of the far-IR(FIR) continuum. The [C II], CO, and FIR continuum emission may be modeled as arising from photodissociation regions (PDRs) that have a characteristic gas density of n approx. 10(exp 4.2)/cu cm., and that are illuminated by a far-UV radiation field approx. 10(exp 3.2) times more intense than the local interstellar radiation field. The mass in these PDRs accounts for approximately half of the molecular gas mass in this galaxy. The L[C II]/L(sub F1R) ratio is higher than observed in local ultraluminous infrared galaxies or in the few high-redshift QSOs detected in [C II], but the L[CII]/L(sub FIR) and L(sub CO)/L(sub FIR) ratios are similar to the values seen in nearby starburst galaxies

  7. Reviving the African wolf Canis lupus lupaster in North and West Africa: a mitochondrial lineage ranging more than 6,000 km wide.

    PubMed

    Gaubert, Philippe; Bloch, Cécile; Benyacoub, Slim; Abdelhamid, Adnan; Pagani, Paolo; Djagoun, Chabi Adéyèmi Marc Sylvestre; Couloux, Arnaud; Dufour, Sylvain

    2012-01-01

    The recent discovery of a lineage of gray wolf in North-East Africa suggests the presence of a cryptic canid on the continent, the African wolf Canis lupus lupaster. We analyzed the mtDNA diversity (cytochrome b and control region) of a series of African Canis including wolf-like animals from North and West Africa. Our objectives were to assess the actual range of C. l. lupaster, to further estimate the genetic characteristics and demographic history of its lineage, and to question its taxonomic delineation from the golden jackal C. aureus, with which it has been considered synonymous. We confirmed the existence of four distinct lineages within the gray wolf, including C. lupus/familiaris (Holarctic wolves and dogs), C. l. pallipes, C. l. chanco and C. l. lupaster. Taxonomic assignment procedures identified wolf-like individuals from Algeria, Mali and Senegal, as belonging to C. l. lupaster, expanding its known distribution c. 6,000 km to the west. We estimated that the African wolf lineage (i) had the highest level of genetic diversity within C. lupus, (ii) coalesced during the Late Pleistocene, contemporaneously with Holarctic wolves and dogs, and (iii) had an effective population size of c. 80,000 females. Our results suggest that the African wolf is a relatively ancient gray wolf lineage with a fairly large, past effective population size, as also suggested by the Pleistocene fossil record. Unique field observations in Senegal allowed us to provide a morphological and behavioral diagnosis of the African wolf that clearly distinguished it from the sympatric golden jackal. However, the detection of C. l. lupaster mtDNA haplotypes in C. aureus from Senegal brings the delineation between the African wolf and the golden jackal into question. In terms of conservation, it appears urgent to further characterize the status of the African wolf with regard to the African golden jackal.

  8. Measurement of inclusive {pi}{sup 0} production in the charged-current interactions of neutrinos in a 1.3-GeV wide band beam

    SciTech Connect

    Mariani, C.; Dore, U.; Loverre, P. F.; Ludovici, L.; Tornero-Lopez, A.; Burguet-Castell, J.; Catala, J.; Gomez-Cadenas, J.; Novella, P.; Sitjes, G.; Sorel, M.; Alcaraz, J. L.; Andringa, S.; Espinal, X.; Fernandez, E.; Jover Manas, G.; Nova, F.; Rodriguez, A.; Sanchez, F.; Aoki, S.

    2011-03-01

    In this paper, we report on the measurement of the rate of inclusive {pi}{sup 0} production induced by charged-current neutrino interactions in a C{sub 8}H{sub 8} target at a mean energy of 1.3 GeV in the K2K near detector. Out of a sample of 11 606 charged-current neutrino interactions, we select 479 {pi}{sup 0} events with two reconstructed photons. We find that the cross section for the inclusive {pi}{sup 0} production relative to the charged-current quasielastic cross section is ({sigma}{sub CC{pi}{sup 0}}/{sigma}{sub CCQE})=0.426{+-}0.032 (stat){+-}0.035 (syst). The energy-dependent cross section ratio is also measured. The results are consistent with previous experiments for exclusive channels on different targets.

  9. DETECTION OF THE 158 {mu}m [C II] TRANSITION AT z = 1.3: EVIDENCE FOR A GALAXY-WIDE STARBURST

    SciTech Connect

    Hailey-Dunsheath, S.; Nikola, T.; Stacey, G. J.; Oberst, T. E.; Parshley, S. C.; Benford, D. J.; Staguhn, J. G.; Tucker, C. E.

    2010-05-01

    We report the detection of 158 {mu}m [C II] fine-structure line emission from MIPS J142824.0+352619, a hyperluminous (L {sub IR} {approx} 10{sup 13} L {sub sun}) starburst galaxy at z = 1.3. The line is bright, corresponding to a fraction L {sub [CII]}/L {sub FIR} {approx} 2 x 10{sup -3} of the far-IR (FIR) continuum. The [C II], CO, and FIR continuum emission may be modeled as arising from photodissociation regions (PDRs) that have a characteristic gas density of n {approx} 10{sup 4.2} cm{sup -3}, and that are illuminated by a far-UV radiation field {approx}10{sup 3.2} times more intense than the local interstellar radiation field. The mass in these PDRs accounts for approximately half of the molecular gas mass in this galaxy. The L {sub [CII]}/L {sub FIR} ratio is higher than observed in local ultraluminous infrared galaxies or in the few high-redshift QSOs detected in [C II], but the L {sub [CII]}/L {sub FIR} and L {sub CO}/L {sub FIR} ratios are similar to the values seen in nearby starburst galaxies. This suggests that MIPS J142824.0+352619 is a scaled-up version of a starburst nucleus, with the burst extended over several kiloparsecs.

  10. 40Km Into Lebanon,

    DTIC Science & Technology

    1987-07-01

    answer to the difficulties in Palestine, London organized a study of the problem under Lord Peel , a for- mer Secretary of State for India, who in 1937...issued the report of the Commission bearing his name. As Peel saw it, the only solution was to partition Palestine between the two communities. The...minority suggestions. The majority 22 40Km into Lebanon report recommended partition with an economic union, much as Peel had proposed in 1937. A

  11. 1,3-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,3 - Dichlorobenzene ; CASRN 541 - 73 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinog

  12. 1,3-Dichloropropene

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 00 / 001 TOXICOLOGICAL REVIEW OF 1,3 - DICHLOROPROPENE ( CAS No . 542 - 75 - 6 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) May 2000 U.S . Environmental Protection Agency Washington , DC DISCLAIMER This document has been reviewed in accordanc

  13. 1,3-Butadiene

    Integrated Risk Information System (IRIS)

    1,3 - Butadiene ; CASRN 106 - 99 - 0 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic E

  14. KM3NeT

    SciTech Connect

    Jong, M. de; Collaboration: KM3NeT Collaboration

    2015-07-15

    KM3NeT is a large research infrastructure, that will consist of a network of deep-sea neutrino telescopes in the Mediterranean Sea. The main objective of KM3NeT is the discovery and subsequent observation of high-energy neutrino sources in the Universe. A further physics perspective is the measurement of the mass hierarchy of neutrinos. A corresponding study, ORCA, is ongoing within KM3NeT. A cost effective technology for (very) large water Cherenkov detectors has been developed based on a new generation of low price 3-inch photo-multiplier tubes. Following the successful deployment and operation of two prototypes, the construction of the KM3NeT research infrastructure has started. The prospects of the different phases of the implementation of KM3NeT are summarised.

  15. Knob manager (KM) operators guide

    SciTech Connect

    1993-10-08

    KM, Knob Manager, is a tool which enables the user to use the SUNDIALS knob box to adjust the settings of the control system. The followings are some features of KM: dynamic knob assignments with the user friendly interface; user-defined gain for individual knob; graphical displays for operating range and status of each process variable is assigned; backup and restore one or multiple process variable; save current settings to a file and recall the settings from that file in future.

  16. Applying WebMining on KM system

    NASA Astrophysics Data System (ADS)

    Shimazu, Keiko; Ozaki, Tomonobu; Furukawa, Koichi

    KM (Knowledge Management) systems have recently been adopted within the realm of enterprise management. On the other hand, data mining technology is widely acknowledged within Information systems' R&D Divisions. Specially, acquisition of meaningful information from Web usage data has become one of the most exciting eras. In this paper, we employ a Web based KM system and propose a framework for applying Web Usage Mining technology to KM data. As it turns out, task duration varies according to different user operations such as referencing a table-of-contents page, down-loading a target file, and writing to a bulletin board. This in turn makes it possible to easily predict the purpose of the user's task. By taking these observations into account, we segmented access log data manually. These results were compared with results abstained by applying the constant interval method. Next, we obtained a segmentation rule of Web access logs by applying a machine-learning algorithm to manually segmented access logs as training data. Then, the newly obtained segmentation rule was compared with other known methods including the time interval method by evaluating their segmentation results in terms of recall and precision rates and it was shown that our rule attained the best results in both measures. Furthermore, the segmented data were fed to an association rule miner and the obtained association rules were utilized to modify the Web structure.

  17. 1,3,5-Trinitrobenzene

    Integrated Risk Information System (IRIS)

    1,3,5 - Trinitrobenzene ; CASRN 99 - 35 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  18. 120 Gbit/s injection-locked homodyne coherent transmission of polarization-multiplexed 64 QAM signals over 150 km.

    PubMed

    Wang, Yixin; Kasai, Keisuke; Yoshida, Masato; Nakazawa, Masataka

    2014-12-15

    We describe an injection-locked 64 QAM homodyne coherent transmission, which is the highest QAM multiplicity realized with an injection locking technique. The frequency locking range of the local oscillator (LO) was as wide as 1 GHz. The phase noise was only 0.2 deg, which is 1/3 of that obtained with our previous OVCO-based OPLL (0.6 deg.). As a result, a 120 Gbit/s polarization-multiplexed 64 QAM signal was successfully transmitted over 150 km with a simple receiver configuration and low DSP complexity.

  19. Nitro Derivatives of 1,3,5-Triazepine as Potential High-Energy Materials

    NASA Astrophysics Data System (ADS)

    Singh, Hari Ji; Upadhyay, Manish Kumar

    2013-10-01

    Structure optimization and frequency calculation of six nitro derivatives of 1,3,5-triazepine were performed using a MP2(FULL)/6-311G(d,p) method. In order to obtain reliable energy data, single-point energy and subsequently thermodynamic properties of the species considered were calculated at a fairly high level of theory, CCSD(T)/6-311G(d,p). Solid-phase heats of formation and crystal density were determined using an electrostatic potential (ESP) method utilizing wave function analysis-surface analysis suite (WFA-SAS) code. The result shows that all nitro derivatives possess high positive heats of formation that increase with an increase in the number of nitro groups attached to the ring moiety. The crystal density was found to be in the range of 1.67-1.90 g/cm3. Detonation properties of the compounds were estimated using the Kamlet-Jacobs equation. The results showed that detonation velocity (D) and detonation pressure (P) increased with an increase in the number of nitro groups attached at the ring moiety. It was found that all six nitro derivatives of the title compound had better or comparable performance characteristics than the most widely used commercial explosives, such as TNT, research and development explosives (RDX), and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX). The trinitro derivative (1,3,5-trinitro-1,3,5-triazepine, F) yielded detonation pressure (P) and detonation velocity (D) of 45.5 GPa and 9.23 km/s, respectively, at a loading density of 1.90 g/cm3, which are superior to the most powerful available explosive HMX (P = 39.00 GPa and D = 9.11 km/s). The results obtained during the present study show that the title compounds can be used as promising futuristic high-energy-density materials (HEDMs).

  20. Peregrine 100-km Sounding Rocket Project

    NASA Technical Reports Server (NTRS)

    Zilliac, Gregory

    2012-01-01

    The Peregrine Sounding Rocket Program is a joint basic research program of NASA Ames Research Center, NASA Wallops, Stanford University, and the Space Propulsion Group, Inc. (SPG). The goal is to determine the applicability of this technology to a small launch system. The approach is to design, build, and fly a stable, efficient liquefying fuel hybrid rocket vehicle to an altitude of 100 km. The program was kicked off in October of 2006 and has seen considerable progress in the subsequent 18 months. This research group began studying liquifying hybrid rocket fuel technology more than a decade ago. The overall goal of the research was to gain a better understanding of the fundamental physics of the liquid layer entrainment process responsible for the large increase in regression rate observed in these fuels, and to demonstrate the effect of increased regression rate on hybrid rocket motor performance. At the time of this reporting, more than 400 motor tests were conducted with a variety of oxidizers (N2O, GOx, LOx) at ever increasing scales with thrust levels from 5 to over 15,000 pounds (22 N to over 66 kN) in order to move this technology from the laboratory to practical applications. The Peregrine program is the natural next step in this development. A number of small sounding rockets with diameters of 3, 4, and 6 in. (7.6, 10.2, and 15.2 cm) have been flown, but Peregrine at a diameter of 15 in. (38.1 cm) and 14,000-lb (62.3-kN) thrust is by far the largest system ever attempted and will be one of the largest hybrids ever flown. Successful Peregrine flights will set the stage for a wide range of applications of this technology.

  1. Focusing of relative plate motion at a continental transform fault: Cenozoic dextral displacement >700 km on New Zealand's Alpine Fault, reversing >225 km of Late Cretaceous sinistral motion

    NASA Astrophysics Data System (ADS)

    Lamb, Simon; Mortimer, Nick; Smith, Euan; Turner, Gillian

    2016-03-01

    The widely accepted ˜450 km Cenozoic dextral strike-slip displacement on New Zealand's Alpine Fault is large for continental strike-slip faults, but it is still less than 60% of the Cenozoic relative plate motion between the Australian and Pacific plates through Zealandia, with the remaining motion assumed to be taken up by rotation and displacement on other faults in a zone up to 300 km wide. We show here that the 450 km total displacement across the Alpine Fault is an artifact of assumptions about the geometry of New Zealand's basement terranes in the Eocene, and the actual Cenozoic dextral displacement across the active trace is greater than 665 km, with more than 700 km (and <785 km since 25 Ma) occurring in a narrow zone less than 10 km wide. This way, the Alpine Fault has accommodated almost all (>94%) of the relative plate motion in the last 25 Ma at an average rate in excess of 28 mm/yr. It reverses more than 225 km (and <300 km) of sinistral shear through Zealandia in the Late Cretaceous, when Zealandia lay on the margin of Gondwana, providing a direct constraint on the kinematics of extension between East and West Antarctica at this time.

  2. Neutral Wind Observations below 200 km altitudes

    NASA Astrophysics Data System (ADS)

    Watanabe, S.; Abe, T.; Habu, H.; Kakinami, Y.; Larsen, M. F.; Pfaff, R. F., Jr.; Yamamoto, M.

    2015-12-01

    Neutral Wind Observations below 200 km altitudesS. Watanabe1, T. Abe2, H. Habu2, Y. Kakinami3, M. Larsen4, R. Pfaff5, M. Yamamoto6, M-Y. Yamamoto31Hokkaido University/Hokkaido Information University, 2JAXA/ISAS, 3Kochi University of Technology, 4Clemson University, 5NASA/Goddard Space Flight Center, 6Kyoto University, Neutral wind in the thermosphere is one of the key parameters to understand the ionosphere-thermosphere coupling process. JAXA/ISAS successfully launched sounding rockets from Uchinoura Space Center (USC) on September 2, 2007, January 12, 2012, and July 20, 2013, and NASA launched sounding rockets from Kwajalein on May 7, 2013 and from Wallops on July 4, 2013. The rockets installed Lithium and/or TMA canisters as well as instruments for plasma and electric and magnetic fields. The atomic Lithium gases were released at altitudes between 150 km and 300 km in the evening on September 2, 2007, at altitude of ~100 km in the morning on January 12, 2012, at altitude of ~120km in the midnight on July 20, 2013, at altitude between 150 km and 300 km in the evening on May 7, 2013 and at altitude of ~150 km in the noon on July 4, 2013. The Lithium atoms were scattering sunlight by resonance scattering with wavelength of 670nm. However, the Lithium atoms scattered moon light on July 20, 2013. The moon light scattering is the first time to use for thermospheric wind measurement in the midnight. The Lithium clouds/trails and TMA trails showed clearly the neutral wind shears and atmospheric waves at ~150 km altitude in the lower thermosphere for all local time.

  3. News from KM3NeT

    SciTech Connect

    Katz, Ulrich F.; Collaboration: KM3NeT Collaboration

    2014-11-18

    KM3NeT is a future research infrastructure in the Mediterranean Sea, hosting a multi-cubic-kilometre neutrino telescope and nodes for Earth and Sea sciences. In this report we shortly summarise the genesis of the KM3NeT project and present key elements of its technical design. The physics objectives of the KM3NeT neutrino telescope and some selected sensitivity estimates are discussed. Finally, some first results from prototype operations and the next steps towards implementation – in particular the first construction phase in 2014/15 – are described.

  4. Towards Mapping the Ocean Surface Topography at 1 km Resolution

    NASA Technical Reports Server (NTRS)

    Fu, Lee-Lueng; Rodriquez, Ernesto

    2006-01-01

    We propose to apply the technique of synthetic aperture radar interferometry to the measurement of ocean surface topography at spatial resolution approaching 1 km. The measurement will have wide ranging applications in oceanography, hydrology, and marine geophysics. The oceanographic and related societal applications are briefly discussed in the paper. To meet the requirements for oceanographic applications, the instrument must be flown in an orbit with proper sampling of ocean tides.

  5. Status of KM3NeT

    NASA Astrophysics Data System (ADS)

    Riccobene, G.

    2016-07-01

    The recent observation of cosmic neutrinos by IceCube has pushed the quest towards the identification of cosmic sources of high-energy particles. The KM3NeT Collaboration is now ready to launch the massive construction of detection units to be installed in deep sea to build a km-cubic size neutrino telescope. The main elements of the detector, the status of the project and the expected perfomances are briefly reported.

  6. FL V1.3

    SciTech Connect

    Rothganger, Frederick

    2009-08-03

    A library of utility classes for computer vision. Contains implementations of various well-known image processing techniques, such as interest point operators and region descriptors. Includes interfaces to various libraries for image and video I/O, as well as an interface to LAPACK/BLAS. FL was developed at the University of Illinois, Urbana-Champaign (UIUC) and released under an open source license. Version 1.2 was a maintenance release provided by SNL under the LGPL license. Version 1.3 is a maintenance release, containing the following changes: - Improved image format handling. Now handles strided and planar memory layouts and a wider range of pixel formats. - Improved image file I/O, including better support for metadata, a wider range of stored pixel types, and a couple of new file formats. - Improvements to DOG and SIFT, and efficiency improvements in low-level convolution. - Improvements to networking, including a generic TCP listener. - Various improvements to numerical processing. The HISTORY file included in the distribution contains a more detailed description of the changes.

  7. Plasma cortisol and testosterone following 19-km and 42-km kayak races.

    PubMed

    Lutoslawska, G; Obminski, Z; Krogulski, A; Sendecki, W

    1991-12-01

    Plasma cortisol and testosterone levels were examined in five, elite, male kayakers before and after 19-km and 42-km kayak races. Both races resulted in significant elevation in plasma cortisol and observed increase is likely to depend on race duration, being much more pronounced after 42-km race compared to 19-km. It should be stressed that observed elevation in cortisol level after 42-km race was higher than reported previously after a marathon run. This finding is in line with reports on hormonal changes in response to arms exercise. Both contests caused a decrease in plasma testosterone level, but the difference between races was not significant. Testosterone/cortisol ratio dropped significantly immediately after the races and the observed decrease was more dominant after the 42-km distance. On the next day, 18 h after the races plasma cortisol, testosterone levels and T/C ratio returned to basal level indicating recuperation from post exercise changes.

  8. KM3NeT-ARCA project status and plan

    NASA Astrophysics Data System (ADS)

    Coniglione, R.

    2016-04-01

    The KM3NeT Collaboration aims at building a research infrastructure in the depths of the Mediterranean Sea hosting a cubic kilometre neutrino telescope. The KM3NeT/ARCA detector is the ideal instrument to look for high-energy neutrino sources thanks to the latitude of the detector and to the optical characteristics of the sea water. The detector latitude allows for a wide coverage of the observable sky including the region of the Galactic centre and the optical sea water properties allow for the measure of the neutrino direction with excellent angular resolution also for cascade events. The technologically innovative components of the detector and the status of construction will be presented as well as the capability it offers to discover neutrinos.

  9. MODIS 3 km and 10 km aerosol optical depth for China: Evaluation and comparison

    NASA Astrophysics Data System (ADS)

    He, Qingqing; Zhang, Ming; Huang, Bo; Tong, Xuelian

    2017-03-01

    The recently released Moderate Resolution Imaging Spectrometer (MODIS) Collection 6 introduced a fine scale aerosol optical depth (AOD) distribution, the 3 km product, which is expected to perform well in analyzing aerosols and identifying local air pollution, especially in the severely polluted atmosphere of China. However, few detailed evaluations of regional variations have been conducted. In this paper, we evaluate MODIS 3 km and 10 km AOD products for China against ground-based measurements and compare their performance with respect to spatial and temporal variations. The ground validations indicate that the two products are generally correlated well to ground-based observations. Spatially, the 3 km product slightly outperform the 10 km product in well-developed areas of southern China. Temporally, both products perform worse during spring and summer. Atmospheric clouds and underlying surface are two key factors that influence the accuracy and number of retrievals for both products. The comparison analysis reveals the newly introduced AOD product clearly shows good relationships with the coarse resolution retrievals in spatial and temporal variation but significant differences regarding details. The 3 km AOD product provides better aerosol gradients, more retrievals in bare areas of western China and some spikes of diurnal variation in cloudy days. Seasonal comparisons show the 3 km AOD product is higher than the 10 km product in all seasons, especially during spring and summer. Although the 3 km product for China generally performs slightly worse than the 10 km product, the added information of the MODIS 3 km AOD product shows potential for studying local aerosol characterization, and may facilitate studies of air pollution.

  10. The estimation of 550 km x 550 km mean gravity anomalies. [from free atmosphere gravimetry data

    NASA Technical Reports Server (NTRS)

    Williamson, M. R.; Gaposchkin, E. M.

    1975-01-01

    The calculation of 550 km X 550 km mean gravity anomalies from 1 degree X 1 degree mean free-air gravimetry data is discussed. The block estimate procedure developed by Kaula was used, and estimates for 1452 of the 1654 blocks were obtained.

  11. Km3Net Italy - Seafloor network

    NASA Astrophysics Data System (ADS)

    Papaleo, Riccardo

    2016-04-01

    The KM3NeT European project aims to construct a large volume underwater neutrino telescope in the depths of the Mediterranean Sea. INFN and KM3NeT collaboration, thanks to a dedicated funding of 21.000.000 € (PON 2007-2013), are committed to build and deploy the Phase 1 of the telescope, composed of a network of detection units: 8 towers, equipped with single photomultiplier optical modules, and 24 strings, equipped with multi-photomultipliers optical modules. All the towers and strings are connected to the main electro optical cable by means of a network of junction boxes and electro optical interlink cables. Each junction box is an active node able to provide all the necessary power to the detection units and to guarantee the data transmission between the detector and the on-shore control station. The KM3NeT Italia project foresees the realization and the installation of the first part of the deep sea network, composed of three junction boxes, one for the towers and two for the strings. In July 2015, two junction boxes have been deployed and connected to the new cable termination frame installed during the same sea campaign. The third and last one will be installed in November 2015. The status of the deep sea network is presented together with technical details of the project.

  12. 50 CFR 1.3 - Service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Service. 1.3 Section 1.3 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.3 Service. Service means the United States Fish and Wildlife Service, Department of the Interior....

  13. 45 CFR 1216.1-3 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Policy. 1216.1-3 Section 1216.1-3 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-3 Policy. (a) Volunteers enrolled or participating in...

  14. 45 CFR 1211.1-3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Definitions. 1211.1-3 Section 1211.1-3 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-3 Definitions. (a) Volunteer means a person enrolled and currently serving as a full-time volunteer...

  15. 45 CFR 1210.1-3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Definitions. 1210.1-3 Section 1210.1-3 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA TRAINEE DESELECTION AND VOLUNTEER EARLY TERMINATION PROCEDURES General § 1210.1-3 Definitions. (a) Trainee means a person enrolled in...

  16. 5 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 1.3 Section 1.3 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.3 Definitions. As used in the rules in this subchapter: (a) Competitive service shall have the...

  17. 43 CFR 8365.1-3 - Vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Vehicles. 8365.1-3 Section 8365.1-3 Public... OF THE INTERIOR RECREATION PROGRAMS VISITOR SERVICES Rules of Conduct § 8365.1-3 Vehicles. (a) When operating a vehicle on the public lands, no person shall exceed posted speed limits, willfully...

  18. 43 CFR 8365.1-3 - Vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Vehicles. 8365.1-3 Section 8365.1-3 Public... OF THE INTERIOR RECREATION PROGRAMS VISITOR SERVICES Rules of Conduct § 8365.1-3 Vehicles. (a) When operating a vehicle on the public lands, no person shall exceed posted speed limits, willfully...

  19. 43 CFR 8365.1-3 - Vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Vehicles. 8365.1-3 Section 8365.1-3 Public... OF THE INTERIOR RECREATION PROGRAMS VISITOR SERVICES Rules of Conduct § 8365.1-3 Vehicles. (a) When operating a vehicle on the public lands, no person shall exceed posted speed limits, willfully...

  20. 43 CFR 8365.1-3 - Vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Vehicles. 8365.1-3 Section 8365.1-3 Public... OF THE INTERIOR RECREATION PROGRAMS VISITOR SERVICES Rules of Conduct § 8365.1-3 Vehicles. (a) When operating a vehicle on the public lands, no person shall exceed posted speed limits, willfully...

  1. Twisted light transmission over 143 km

    NASA Astrophysics Data System (ADS)

    Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton

    2016-11-01

    Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.

  2. 45-km horizontal path optical link demonstration

    NASA Astrophysics Data System (ADS)

    Biswas, Abhijit; Wright, Malcolm W.; Sanii, Babak; Page, Norman A.

    2001-06-01

    Observations made during a mountain-top-to-mountain-top horizontal optical link demonstration are described. The optical link spans a range of 46 Km at an average altitude of 2 Km above sea level. A multibeam beacon comprised of eight laser beams emerging from four multimode fiber coupled lasers (780 nm) is launched through a 0.6 m diameter telescope located at the JPL Table Mountain Facility (TMF) in Wrightwood, California. The multibeam beacon is received at Strawberry Peak located in the San Bernardino Mountains of California. The NASA, JPL developed optical communications demonstrator (OCD) receives the beacon, senses the atmospheric turbulence induced motion and using an upgraded fine steering loop actively points a communications laser beam (852 nm, 400 Mbps on-off key modulated, PN7 pseudo random bit sequence) to TMF. The eight-beam beacon allowed a four-fold reduction in normalized irradiance or scintillation index. This in turn was sufficient to eliminate beacon fades sensed by the OCD and enable performance evaluation of the fine steering loop. The residual tracking error was determined to be +/- 1.1 to +/- 1.7 (mu) rad compared to a model prediction of +/- 3.4 (mu) rad. The best link performance observed showed average bit error rates (BER) of 1E-5 over long durations (30 seconds); however, instantaneous BERs of at least 0.8E-6 over durations of 2 ms were observed. The paper also discusses results pertaining to atmospheric effects, link analysis, and overall performance.

  3. Twisted light transmission over 143 km.

    PubMed

    Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton

    2016-11-29

    Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.

  4. Predicting km-scale shear zone formation

    NASA Astrophysics Data System (ADS)

    Gerbi, Christopher; Culshaw, Nicholas; Shulman, Deborah; Foley, Maura; Marsh, Jeffrey

    2015-04-01

    Because km-scale shear zones play a first-order role in lithospheric kinematics, accurate conceptual and numerical models of orogenic development require predicting when and where they form. Although a strain-based algorithm in the upper crust for weakening due to faulting appears to succeed (e.g., Koons et al., 2010, doi:10.1029/2009TC002463), a comparable general rule for the viscous crust remains unestablished. Here we consider two aspects of the geological argument for a similar algorithm in the viscous regime, namely (1) whether predicting km-scale shear zone development based on a single parameter (such as strain or shear heating) is reasonable; and (2) whether lithologic variability inherent in most orogenic systems precludes a simple predictive rule. A review of tectonically significant shear zones worldwide and more detailed investigations in the Central Gneiss belt of the Ontario segment of the Grenville Province reveals that most km-scale shear zones occur at lithological boundaries and involve mass transfer, but have fairly little else in common. As examples, the relatively flat-lying Twelve Mile Bay shear zone in the western Central Gneiss belt bounds the Parry Sound domain and is likely the product of both localized anatexis and later retrograde hydration with attendant metamorphism. Moderately dipping shear zones in granitoids of the Grenville Front Tectonic Zone apparently resulted from cooperation among several complementary microstructural processes, such as grain size reduction, enhanced diffusion, and a small degree of metamorphic reaction. Localization into shear zones requires the operation of some spatially restricted processes such as stress concentration, metamorphism/fluid access, textural evolution, and thermal perturbation. All of these could be due in part to strain, but not necessarily linearly related to strain. Stress concentrations, such as those that form at rheological boundaries, may be sufficient to nucleate high strain

  5. 36 CFR 1.3 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Penalties. 1.3 Section 1.3 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS... 1 through 7, 12 and 13 of this chapter, within a park area not covered in paragraphs (b) or (c)...

  6. 45 CFR 1206.1-3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Definitions. 1206.1-3 Section 1206.1-3 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GRANTS AND CONTRACTS-SUSPENSION AND TERMINATION AND DENIAL OF APPLICATION FOR REFUNDING Suspension and Termination of Assistance §...

  7. 21 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Definitions. 1.3 Section 1.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT... after shipment or delivery in interstate commerce. (b) Label means any display of written, printed,...

  8. Synthesis of 1,3,3-trinitroazetidine

    DOEpatents

    Hiskey, M.A.; Coburn, M.D.

    1994-08-09

    A process of preparing 1,3,3-trinitroazetidine includes forming a 5-hydroxymethyl-5-nitro-1-alkyltetrahydro-1,3-oxazine, e.g., reacting a 1,3,5-trialkyl hexahydrotriazine and tris(hydroxymethyl)nitromethane, ring opening said 5-hydroxymethyl-5-nitro-1-alkyltetrahydro-1,3-oxazine to form a 3-alkylamino-2-hydroxymethyl-2-nitro-1-propanol salt, ring closing said 3-alkylamino-2-hydroxymethyl-2-nitro-1-propanol salt to form a 3-hydroxymethyl-3-nitro-1-alkylazetidine salt, nitrating said 3-hydroxymethyl-3-nitro-1-alkylazetidine salt to form a 1-alkyl-3,3-dinitroazetidine, and converting said 1-alkyl-3,3-dinitroazetidine into 1,3,3-trinitroazetidine is disclosed. 1 fig.

  9. Synthesis of 1,3,3-trinitroazetidine

    DOEpatents

    Hiskey, Michael A.; Coburn, Michael D.

    1994-01-01

    A process of preparing 1,3,3-trinitroazetidine including forming a 5-hydroxymethyl-5-nitro-1-alkyltetrahydro-1,3-oxazine, e.g., reacting a 1,3,5-trialkyl hexahydrotriazine and tris(hydroxymethyl)nitromethane, ring opening said 5-hydroxymethyl-5-nitro-1-alkyltetrahydro-1,3-oxazine to form a 3-alkylamino-2-hydroxymethyl-2-nitro-1-propanol salt, ring closing said 3-alkylamino-2-hydroxymethyl-2-nitro-1-propanol salt to form a 3-hydroxymethyl-3-nitro-1-alkylazetidine salt, nitrating said 3-hydroxymethyl-3-nitro-1-alkylazetidine salt to form a 1-alkyl-3,3-dinitroazetidine, and converting said 1-alkyl-3,3-dinitroazetidine into 1,3,3-trinitroazetidine is disclosed.

  10. 45 Km Horizontal Path Optical Link Experiment

    NASA Technical Reports Server (NTRS)

    Biswas, A.; Ceniceros, J.; Novak, M.; Jeganathan, M.; Portillo, A.; Erickson, D.; Depew, J.; Sanii, B.; Lesh, J. R.

    2000-01-01

    Mountain-top to mountain-top optical link experiments have been initiated at JPL, in order to perform a systems level evaluation of optical communications. Progress made so far is reported. ne NASA, JPL developed optical communications demonstrator (OCD) is used to transmit a laser signal from Strawberry Peak (SP), located in the San Bernadino mountains of California. This laser beam is received by a 0.6 m aperture telescope at JPL's Table Mountain Facility (TMF), located in Wrightwood, California. The optical link is bi-directional with the TMF telescope transmitting a continuous 4-wave (cw) 780 run beacon and the OCD sending back a 840 nm, 100 - 500 Mbps pseudo noise (PN) modulated, laser beam. The optical link path is at an average altitude of 2 km above sea level, covers a range of 46.8 km and provides an atmospheric channel equivalent to approx. 4 air masses. Average received power measured at either end fall well within the uncertainties predicted by link analysis. The reduction in normalized intensity variance (sigma(sup 2, sub I)) for the 4-beam beacon, compared to each individual beam, at SP, was from approx. 0.68 to 0.22. With some allowance for intra-beam mis-alignment, this is consistent with incoherent averaging. The sigma(sup2, sub I) measured at TMF approx. 0.43 +/- 0.22 exceeded the expected aperture averaged value of less than 0.1, probably because of beam wander. The focused spot sizes of approx. 162 +/- 6 microns at the TMF Coude and approx. 64 +/- 3 microns on the OCD compare to the predicted size range of 52 - 172 microns and 57 - 93 microns, respectively. This is consistent with 4 - 5 arcsec of atmospheric "seeing". The preliminary evaluation of OCD's fine tracking indicates that the uncompensated tracking error is approx. 3.3 micro rad compared to approx. 1.7 micro rad observed in the laboratory. Fine tracking performance was intermittent, primarily due to beacon fades on the OCD tracking sensor. The best bit error rates observed while

  11. The Distribution of High Altitude (70KM) Ice Clouds in the Mars Atmospere from MGS TES and MOC LIMB Observations

    NASA Astrophysics Data System (ADS)

    Clancy, R. T.; Wolff, M.; Whitney, B.; Cantor, B.

    2004-11-01

    The Pathfinder descent entry detected extremely cold temperatures at 70-100 km altitudes (Schofield et al., 1997), suggesting the possibility of frequent CO2 ice cloud occurrence in the 70-80 km altitude region (Clancy and Sandor, 1998). However, prior to recent MGS limb measurements, it remained unclear whether CO2 or water ice aerosols are ever present at >60 km altitudes. Dust aerosols have been identified at such high altitudes in Mariner 9 (Anderson and Leovy, 1978), Viking (Jaquin et al., 1986), and MGS limb measurements (Clancy, 2003), associated with the 1971, 1977, and 2001 planet-encircling dust storms, respectively. The highest detached ice cloud identified from Viking limb data occurred at a projected tangent altitude of 55km, at 16S, 72W and Ls = 176° (Jaquin et al., 1986; recently modeled by Montmessin et al., 2002). The seasonal period and location of this detached limb cloud appears consistent with 55-75 km detached limb clouds that we have observed as prominent in MGS TES solarband limb scans and MGS MOC wide-angle (WA) limb images (1-3 pm local times). Their occurrence frequency approaches unity at the beginning and end of the aphelion northern summer season on Mars (centered at Ls =30° and 150° ), where they are confined to equatorial (15S-15N) latitudes and two relatively narrow longitude ranges (330-20W and 50-120W). Cloud altitudes of 65-75km are derived from the distribution of projected limb heights. Peak optical (visible) depths are quite significant (0.01) for the low pressure region of formation ( 1 microbar). It remains unclear as to their composition (water or CO2), although coadded MGS thermal IR spectra indicate potential for water ice identification and particle size information. We will present the spatial and temporal distribution of these mesospheric clouds indicated in the MSG TES and MOC visible limb data, and derived vertical profiles of optical depth and particle size based upon a monte carlo spherical RT analysis of the

  12. Teleportation of entanglement over 143 km.

    PubMed

    Herbst, Thomas; Scheidl, Thomas; Fink, Matthias; Handsteiner, Johannes; Wittmann, Bernhard; Ursin, Rupert; Zeilinger, Anton

    2015-11-17

    As a direct consequence of the no-cloning theorem, the deterministic amplification as in classical communication is impossible for unknown quantum states. This calls for more advanced techniques in a future global quantum network, e.g., for cloud quantum computing. A unique solution is the teleportation of an entangled state, i.e., entanglement swapping, representing the central resource to relay entanglement between distant nodes. Together with entanglement purification and a quantum memory it constitutes a so-called quantum repeater. Since the aforementioned building blocks have been individually demonstrated in laboratory setups only, the applicability of the required technology in real-world scenarios remained to be proven. Here we present a free-space entanglement-swapping experiment between the Canary Islands of La Palma and Tenerife, verifying the presence of quantum entanglement between two previously independent photons separated by 143 km. We obtained an expectation value for the entanglement-witness operator, more than 6 SDs beyond the classical limit. By consecutive generation of the two required photon pairs and space-like separation of the relevant measurement events, we also showed the feasibility of the swapping protocol in a long-distance scenario, where the independence of the nodes is highly demanded. Because our results already allow for efficient implementation of entanglement purification, we anticipate our research to lay the ground for a fully fledged quantum repeater over a realistic high-loss and even turbulent quantum channel.

  13. 21 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... REGULATIONS General Provisions § 1.3 Definitions. (a) Labeling includes all written, printed, or graphic... graphic matter on the immediate container of any article, or any such matter affixed to any...

  14. 21 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... REGULATIONS General Provisions § 1.3 Definitions. (a) Labeling includes all written, printed, or graphic... graphic matter on the immediate container of any article, or any such matter affixed to any...

  15. 21 CFR 1.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... REGULATIONS § 1.3 Definitions. (a) Labeling includes all written, printed, or graphic matter accompanying an... delivery in interstate commerce. (b) Label means any display of written, printed, or graphic matter on...

  16. EVLA/NMA: Within and Beyond the 21-km Radius

    NASA Astrophysics Data System (ADS)

    Durand, Steve; Romney, Jonathan D.

    NRAO's Expanded Very Large Array (EVLA) project is being implemented in two phases. Each involves extremely wide- bandwidth data transmission over optical fibers, but the two phases necessarily involve quite different approaches to the required fiber infrastructure, which make for an interesting contrast. Phase 1, formally called the "Ultrasensitive Array", involves replacing almost all of the existing electronics, leaving only the mechanical and track infrastructure of the VLA. The data transmission system being implemented for Phase 1 uses dedicated optical fibers, currently being buried at the VLA site. Twelve standard single-mode fibers will run from each of 72 antenna pads to the central building. One of these fibers will support the wideband data transmission system, using a dense wavelength division multiplexing technique to carry a bandwidth of 96 Gbps (120 Gbps formatted) per antenna. Fibers from the 27 active antenna pads will carry a total bandwidth of 2.6 Tbps. The longest of these fibers will extend the full 21- km length of each arm. Phase 2 will add the "New Mexico Array". Eight new stations will be built, and the electronics of the VLBA Pie Town and Los Alamos stations will be upgraded, to create a medium-resolution array, with sensitivity even higher than Phase 1. All ten NMA stations will lie within the State of New Mexico. The new antennas will range as far as 265 km from the VLA site, and will be located so as to facilitate access to existing fiber trunks installed, primarily, by rural telephone companies. These trunks include numerous unused fibers which, it is anticipated, can be leased economically. The longest fiber run from the VLA is 480 km. The same 96-Gbps total bandwidth per station will be supported, with the same underlying sub-band structure. Signals from up to three NMA stations will be multiplexed onto a single fiber in the existing trunks. This will limit the total length of fiber which must be leased or acquired to about 1240 km.

  17. A 700 km long crustal transect across northern Morocco

    NASA Astrophysics Data System (ADS)

    Carbonell, Ramon; Gallart, Josep; Díaz, Jordi; Gil, Alba; Harnafi, Mimoun; Ouraini, Fadila; Ayarza, Puy; Teixell, Antonio; Arboleya, Maria Luisa; Palomeras, Imma; Levander, Alan

    2013-04-01

    Two controlled-source wide angle seismic reflection experiments have been acquired recently (2010 and 2011) in northern Africa across Morocco. A lithospheric scale transect can be constructed by joining both data sets. Hence, an approximately 700 km-long seismic velocity cross section can be derived. From south-to-north the transect goes from the Sahara Platform, south of Merzouga, to Tanger in the north. The first experiment, SIMA, aimed to constrain the crustal structure across the Atlas Mountains. The Rif, the orogenic belt located just south of the coast of Alboran Sea, was the target of the second experiment, RIFSIS. In both cases 900 recording instruments (TEXANS) from the IRIS-PASSCAL instrument center were used to record the acoustic energy generated by explosion shots. In both experiments the shots consisted of 1 TM of explosives fired in ~30 m deep boreholes. Although the data quality varies from shot to shot, key seismic phases as Pg, PmP, Pn, and a few intra-crustal arrivals have been identified to constrain the velocity-depth structure along the whole transect. Forward modelling of the seismic reflection/refraction phases reveals a crust consisting of 3 layers in average. The Moho topography shows from south to north a relatively moderate crustal root beneath the High Atlas, which can reach 40-42 km depth. The crust is thicker beneath the Rif where the Moho is imaged as an asymmetric feature that locally defines a crustal root reaching depths of 50 km and suggesting a crustal imbrication. P wave velocities are rather low in the crust and upper mantle. First arrivals/reflections tomography supports the forward modelling results. Low fold wide-angle stacks obtained by using hyperbolic move-out reveals the geometry of the Moho along the entire transect. Beneath the Atlas, the moderate crustal root inferred is not isostatically consistent with the high surface elevations, hence supporting the idea of a 'mantle plume' as main contributor to the Atlas

  18. KM3NeT: towards a km 3-scale neutrino telescope in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Distefano, C.; KM3NeT Consortium

    2009-05-01

    The observation of high energy neutrinos ( ≳1 TeV) from astrophysical sources would substantially improve our knowledge and understanding of the non-thermal processes in these sources, and would in particular pinpoint the accelerators of cosmic rays. Theoretical predictions indicate that km 3-scale detectors are needed to detect astrophysical neutrino fluxes. That is the reason why the three Mediterranean experiments, ANTARES, NEMO and NESTOR are working together on preparing KM3NeT, a large deep-sea neutrino telescope in the Mediterranean Sea which will survey a large part of the Galactic disc, including the Galactic Centre. It will complement the IceCube telescope currently under construction at the South Pole. Furthermore, the improved optical properties of sea water, compared to Antarctic ice, will allow for a better angular resolution and hence a better background rejection. The construction of this detector will require the solution of technological problems common to many deep submarine installations, and will help paving the way for other deep-sea research facilities. In this paper the major activities and the status of KM3NeT are presented.

  19. KM3NeT: towards a km3-scale neutrino telescope in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Km3NeT Consortium; Distefano, C.; KM3NeT Consortium

    2009-05-01

    The observation of high energy neutrinos (≳1 TeV) from astrophysical sources would substantially improve our knowledge and understanding of the non-thermal processes in these sources, and would in particular pinpoint the accelerators of cosmic rays. Theoretical predictions indicate that km3-scale detectors are needed to detect astrophysical neutrino fluxes. That is the reason why the three Mediterranean experiments, ANTARES, NEMO and NESTOR are working together on preparing KM3NeT, a large deep-sea neutrino telescope in the Mediterranean Sea which will survey a large part of the Galactic disc, including the Galactic Centre. It will complement the IceCube telescope currently under construction at the South Pole. Furthermore, the improved optical properties of sea water, compared to Antarctic ice, will allow for a better angular resolution and hence a better background rejection. The construction of this detector will require the solution of technological problems common to many deep submarine installations, and will help paving the way for other deep-sea research facilities. In this paper the major activities and the status of KM3NeT are presented.

  20. Microbial production of 1,3-propanediol.

    PubMed

    Sauer, Michael; Marx, Hans; Mattanovich, Diethard

    2008-01-01

    The introduction of economic production processes for 1,3-propanediol is a success story for the creation of a new market for a (bulk) chemical. The compound and its favorable properties have long been known; also the fermentation of glycerol to 1,3-propanediol had been described more than 120 years ago. Nevertheless, the product remained a specialty chemical until recently, when two new processes were introduced, providing 1,3-propanediol at a competitive price. Remarkably, one of the processes is in the field of white biotechnology and based on microbial fermentation, converting a renewable carbon source into a bulk chemical. This review covers the most important patents that led to the commercialization of bio-based 1,3-propanediol. Furthermore, some of the recent developments towards a sustainable industry are addressed. Similar questions arise for a variety of products if they are to be produced bio-based in large scale. However, special emphasis is given to 1,3-propanediol production.

  1. Preparation and characterization of 18650 Li(Ni 1/3Co 1/3Mn 1/3)O 2/graphite high power batteries

    NASA Astrophysics Data System (ADS)

    He, Yan-Bing; Tang, Zhi-Yuan; Song, Quan-Sheng; Xie, Hui; Yang, Quan-Hong; Liu, Yuan-Gang; Ling, Guo-Wei

    The commercial 18650 Li(Ni 1/3Co 1/3Mn 1/3)O 2/graphite high power batteries were prepared and their electrochemical performance at temperatures of 25 and 50 °C was extensively investigated. The results showed that the charge-transfer resistance (R ct) and solid electrolyte interface resistance (R sei) of the high power batteries at 25 °C decreased as states of charge (SOC) increased from 0 to 60%, whereas R ct and R sei increased as SOC increased from 60 to 100%. The discharge plateau voltage of batteries reduced greatly with the increase in discharge rate at both 25 and 50 °C. The high power batteries could be discharged at a very wide current range to deliver most of their capacity and also showed excellent power cycling performance with discharge rate of as high as 10 C at 25 °C. The elevated working temperature did not influence the battery discharge capacity and cycling performance at lower discharge rates (e.g. 0.5, 1, and 5 C), while it resulted in lower discharge capacity at higher discharge rates (e.g. 10 and 15 C) and bad cycling performance at discharge rate of 10 C. The batteries also exhibited excellent cycle performance at charge rate of as high as 8 C and discharge rate of 10 C.

  2. Carcinogenicity of 1,3-butadiene.

    PubMed Central

    Melnick, R L; Shackelford, C C; Huff, J

    1993-01-01

    1,3-Butadiene, a high-production volume chemical used largely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice. In inhalation studies conducted in mice by the National Toxicology Program, high rates of early lethal lymphomas occurring at exposure levels of 625 ppm or higher reduced the development and expression of later developing tumors at other sites. Use of survival-adjusted tumor rates to account for competing risk factors provided a clearer indication of the dose responses for 1,3-butadiene-induced neoplasms. An increase in lung tumors in female mice was observed at exposure concentrations as low as 6.25 ppm, the lowest concentration ever used in a long-term carcinogenicity study of this gas. Human exposures to 1,3-butadiene by workers employed at facilities that produce this chemical and at facilities that produce styrene-butadiene rubber have been measured at levels higher than those that cause cancer in animals. Furthermore, epidemiology studies have consistently revealed associations between occupational exposure to 1,3-butadiene and excess mortality due to lymphatic and hematopoietic cancers. In response to the carcinogenicity findings for 1,3-butadiene in animals and in humans, the Occupational Safety and Health Administration has proposed lowering the occupational exposure standard for this chemical from 1000 ppm to 2 ppm. Future work is needed to understand the mechanisms of tumor induction by 1,3-butadiene; however, the pursuit of this research should not delay the reduction of human exposure to this chemical. PMID:8354171

  3. Version 1.3 AIM SOFIE measured methane (CH4): Validation and seasonal climatology

    NASA Astrophysics Data System (ADS)

    Rong, P. P.; Russell, J. M.; Marshall, B. T.; Siskind, D. E.; Hervig, M. E.; Gordley, L. L.; Bernath, P. F.; Walker, K. A.

    2016-11-01

    The V1.3 methane (CH4) measured by the Aeronomy of Ice in the Mesosphere (AIM) Solar Occultation for Ice Experiment (SOFIE) instrument is validated in the vertical range of 25-70 km. The random error for SOFIE CH4 is 0.1-1% up to 50 km and degrades to 9% at ˜ 70 km. The systematic error remains at 4% throughout the stratosphere and lower mesosphere. Comparisons with CH4 data taken by the SCISAT Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS) and the Envisat Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) show an agreement within 15% in the altitude range 30-60 km. Below 25 km SOFIE CH4 is systematically higher (≥20%), while above 65 km it is lower by a similar percentage. The sign change from the positive to negative bias occurs between 55 km and 60 km (or 40 km and 45 km) in the Northern (or Southern) Hemisphere. Methane, H2O, and 2CH4 + H2O yearly differences from their values in 2009 are examined using SOFIE and MIPAS CH4 and the Aura Microwave Limb Sounder (MLS) measured H2O. It is concluded that 2CH4 + H2O is conserved with altitude up to an upper limit between 35 km and 50 km depending on the season. In summer this altitude is higher. In the Northern Hemisphere the difference relative to 2009 is the largest in late spring and the established difference prevails throughout summer and fall, suggesting that summer and fall are dynamically quiet. In both hemispheres during winter there are disturbances (with a period of 1 month) that travel downward throughout the stratosphere with a speed similar to the winter descent.

  4. Highly enantioselective intramolecular 1,3-dipolar cycloaddition: a route to piperidino-pyrrolizidines.

    PubMed

    Vidadala, Srinivasa Rao; Golz, Christopher; Strohmann, Carsten; Daniliuc, Constantin-G; Waldmann, Herbert

    2015-01-07

    Enantioselective catalytic intermolecular 1,3-dipolar cycloadditions are powerful methods for the synthesis of heterocycles. In contrast, intramolecular enantioselective 1,3-dipolar cycloadditions are virtually unexplored. A highly enantioselective synthesis of natural-product-inspired pyrrolidino-piperidines by means of an intramolecular 1,3-dipolar cycloaddition with azomethine ylides is now reported. The method has a wide scope and yields the desired cycloadducts with four tertiary stereogenic centers with up to 99% ee. Combining the enantioselective catalytic intramolecular 1,3-dipolar cycloaddition with a subsequent diastereoselective intermolecular 1,3-dipolar cycloaddition yielded complex piperidino-pyrrolizidines with very high stereoselectivity in a one-pot tandem reaction.

  5. A Dogrib History. Grade 1-3.

    ERIC Educational Resources Information Center

    Fraser, Tara

    A publication on the history and traditional lifestyle of the Dogrib Tribe of Canada's Northwest Territories is intended for use in grades 1-3. Text is printed in large, clear letters and accompanied by many drawings. Some subjects covered are cooking, food, canoes, clothes, homes, and games. Sections are devoted to beavers and caribou and their…

  6. Concertedness of 1,3-Dipolar Cycloadditions.

    ERIC Educational Resources Information Center

    Haque, M. Serajul

    1984-01-01

    There are two conflicting views about the mechanism of 1,3-dipolar cycloadditions to multibonds. To reconcile these viewpoints a concerted, spin-paired, diradical mechanism, based on valence bond theory, is proposed. Each of these three mechanisms is discussed. (JN)

  7. MODIS 3km Aerosol Product: Algorithm and Global Perspective

    NASA Technical Reports Server (NTRS)

    Remer, L. A.; Mattoo, S.; Levy, R. C.; Munchak, L.

    2013-01-01

    After more than a decade of producing a nominal 10 km aerosol product based on the dark target method, the MODIS aerosol team will be releasing a nominal 3 km product as part of their Collection 6 release. The new product differs from the original 10 km product only in the manner in which reflectance pixels are ingested, organized and selected by the aerosol algorithm. Overall, the 3 km product closely mirrors the 10 km product. However, the finer resolution product is able to retrieve over ocean closer to islands and coastlines, and is better able to resolve fine aerosol features such as smoke plumes over both ocean and land. In some situations, it provides retrievals over entire regions that the 10 km product barely samples. In situations traditionally difficult for the dark target algorithm, such as over bright or urban surfaces the 3 km product introduces isolated spikes of artificially high aerosol optical depth (AOD) that the 10 km algorithm avoids. Over land, globally, the 3 km product appears to be 0.01 to 0.02 higher than the 10 km product, while over ocean, the 3 km algorithm is retrieving a proportionally greater number of very low aerosol loading situations. Based on collocations with ground-based observations for only six months, expected errors associated with the 3 km land product are determined to be greater than for the 10 km product: 0.05 0.25 AOD. Over ocean, the suggestion is for expected errors to be the same as the 10 km product: 0.03 0.05 AOD. The advantage of the product is on the local scale, which will require continued evaluation not addressed here. Nevertheless, the new 3 km product is expected to provide important information complementary to existing satellite-derived products and become an important tool for the aerosol community.

  8. 1,3,5-Hydroxybenzene structures in mosses

    USGS Publications Warehouse

    Wilson, M.A.; Sawyer, J.; Hatcher, P.G.; Lerch, H. E.

    1989-01-01

    A number of mosses from widely different families have been studied by cross polarization solid state 13C NMR spectroscopy. Although polysaccharide-type materials dominate the NMR spectra, significant amounts of aromatic carbons are observed in some mosses. Some of this material can be removed by ultrasonic bath treatment, and is lignin derived, probably from impurities from fine root material from associated higher plants. However other material is truly moss-derived and appears to be from 1,3,5-hydroxybenzene structures. This is inconsistent with lignin as being a component of mosses, and suggests a tannin or hydroxybenzofuran polymer is responsible for moss rigidity. ?? 1989.

  9. Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    Integrated Risk Information System (IRIS)

    Hexahydro - 1,3,5 - trinitro - 1,3,5 - triazine ( RDX ) ; CASRN 121 - 82 - 4 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health

  10. Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)

    Integrated Risk Information System (IRIS)

    Octahydro - 1,3,5,7 - tetranitro - 1,3,5,7 - tetr . . . ( HMX ) ; CASRN 2691 - 41 - 0 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I

  11. Biodegradation of hexahydro-1,3,5-trinitro-1,3,5-triazine

    SciTech Connect

    McCormick, N.G.; Cornell, J.H.; Kaplan, A.M.

    1981-11-01

    Biodegradation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) occurs under anaerobic conditions, yielding a number of products, including: hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine, hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine, hexahydro-1,3,5-trinitroso-1,3,5-triazine, hydrazine, 1,1-dimethylhydrazine, 1,2-dimethylhydrazine, formaldehyde, and methanol. A scheme for the biodegradation of RDX is poposed which proceeds via successive reduction of the nitro groups to a point where destabilization and fragmentation of the ring occurs. The noncyclic degradation products arise via subsequent reduction and rearrangement reactions of the fragments. The scheme suggests the presence of several additional compounds, not yet identified. Several of the products are mutagenic or carcinogenic or both. Anaerobic treatment of RDX wastewaters, which also contain high nitrate levels, would permit the denitrification to occur, with concurrent degradation of RDX ultimately to a mixture of hydrazines and methanol. The feasibility of using an aerobic mode in the further degradation of these products is discussed.

  12. Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine

    PubMed Central

    McCormick, N. G.; Cornell, J. H.; Kaplan, A. M.

    1981-01-01

    Biodegradation of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) occurs under anaerobic conditions, yielding a number of products, including: hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine, hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine, hexahydro-1,3,5-trinitroso-1,3,5-triazine, hydrazine, 1,1-dimethyl-hydrazine, 1,2-dimethylhydrazine, formaldehyde, and methanol. A scheme for the biodegradation of RDX is proposed which proceeds via successive reduction of the nitro groups to a point where destabilization and fragmentation of the ring occurs. The noncyclic degradation products arise via subsequent reduction and rearrangement reactions of the fragments. The scheme suggests the presence of several additional compounds, not yet identified. Several of the products are mutagenic or carcinogenic or both. Anaerobic treatment of RDX wastewaters, which also contain high nitrate levels, would permit the denitrification to occur, with concurrent degradation of RDX ultimately to a mixture of hydrazines and methanol. The feasibility of using an aerobic mode in the further degradation of these products is discussed. PMID:16345884

  13. Microphysical Model of the Venus clouds between 40km and 80km

    NASA Astrophysics Data System (ADS)

    McGouldrick, Kevin

    2013-10-01

    I am continuing to adapt the Community Aerosol and Radiation Model for Atmospheres (CARMA) to successfully simulate the multi-layered clouds of Venus. The present version of the one-dimensional model now includes a simple parameterization of the photochemicial production of sulfuric acid around altitudes of 62km, and its thermochemical destruction below cloud base. Photochemical production in the model is limited by the availability of water vapor and insolation. Upper cloud particles are introduced into the model via binary homogeneous nucleation, while the lower and middle cloud particles are created via activation of involatile cloud condensation nuclei. Growth by condensation and coagulation and coalescence are also treated. Mass loadings and particle sizes compare favorably with the in situ observations by the Pioneer Venus Large Probe Particle Size Spectrometer, and mixing ratios of volatiles compare favorably with remotely sensed observations of water vapor and sulfuric acid vapor. This work was supported by the NASA Planetary Atmospheres Program, grant number NNX11AD79G.

  14. The action modes of an extracellular beta-1,3-glucanase isolated from Bacillus clausii NM-1 on beta-1,3-glucooligosaccharides.

    PubMed

    Miyanishi, Nobumitsu; Matsubara, Yasuhito; Hamada, Naoko; Kobayashi, Takeshi; Imada, Chiaki; Watanabe, Etsuo

    2003-01-01

    The mode of action of an extracellular -1,3-glucanase from Bacillus clausii NM-1 on beta-1,3-3glucooligosaccharides and their alditols was studied. The enzyme could not hydrolyze laminaribiose or laminaritriose. beta-1,3-Glucooligosaccharides higher than laminarihexaose were rapidly hydrolyzed, while laminaritetraose was slowly hydrolyzed. The k(cat)/K(m) ratios for a series of beta-1,3-glucooligosaccharides from laminaritetraose to laminariheptaose showed that the substrate binding site of the enzyme covered a wide range of beta-1,3-glucooligosaccharides having six glucose residues. The action pattern of the enzyme on the alditols corresponding to each laminarioligosaccharide suggested that the catalytic site of the enzyme existed between the third and fourth glucose residue from the non-reducing terminal. The value of k(cat)/K(m) also suggested that the sixth binding position contributed to the catalytic efficiency and stability.

  15. Intramolecular Diels–Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles

    PubMed Central

    Elliott, Gregory I.; Fuchs, James R.; Blagg, Brian S. J.; Ishikawa, Hayato; Tao, Houchao; Yuan, Z.-Q.; Boger, Dale L.

    2008-01-01

    Full details of a systematic exploration of the intramolecular [4+2]/[3+2] cycloaddition cascade of 1,3,4-oxadiazoles are disclosed in which the scope and utility of the reaction are defined. PMID:16895427

  16. CMMI(Registered) for Acquisition, Version 1.3. CMMI-ACQ, V1.3

    DTIC Science & Technology

    2010-11-01

    So Norimatsu, Norimatsu Process Engineering Lab, Inc. Mary Lynn Penn, Lockheed Martin Corporation David (Mike) Phillips , Software Engineering...CMMI ® for Acquisition, Version 1.3 CMMI-ACQ, V1.3 CMMI Product Team Improving processes for acquiring better products and services...November 2010 TECHNICAL REPORT CMU/SEI-2010-TR-032 ESC-TR-2010-032 Software Engineering Process Management Program Unlimited distribution

  17. Silyl- and disilanyl-1,3-butadiyne polymers from hexachloro-1,3-butadiene

    DOEpatents

    Barton, T.J.; Ijadi-Maghsoodi, S.

    1990-10-23

    Organosilane polymers having recurring silylene-1,3-butadiyne and/or disilylene-1,3-butadiyne units are prepared in a one-pot synthesis from hexachlorobutadiene. Depending on the organic substituents (R and R[prime]), these polymers have useful film-forming properties, and are converted to the ceramic, silicon carbide upon heating a very uniform high char yields. They can also be pulled into fibers. The polymers are thermally crosslinked above 100 C.

  18. Silyl- and disilanyl-1,3-butadiyne polymers from hexachloro-1,3-butadiene

    DOEpatents

    Barton, Thomas J.; Ijadi-Maghsoodi, Sina

    1990-10-23

    Organosilane polymers having recurring silylene-1,3-butadiyne and/or disilylene-1,3-butadiyne units are prepared in a one-pot synthesis from hexachlorobutadiene. Depending on the organic substituents (R and R'), these polymers have useful film-forming properties, and are converted to the ceramic, silicon carbide upon heating a very uniform high char yields. They can also be pulled into fibers. The polymers are thermally crosslinked above 100.degree. C.

  19. 7 CFR 29.1035 - Mixed color (KM).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Mixed color (KM). 29.1035 Section 29.1035 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1035 Mixed color (KM). Distinctly different colors of the type mingled together....

  20. 7 CFR 29.1035 - Mixed color (KM).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Mixed color (KM). 29.1035 Section 29.1035 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1035 Mixed color (KM). Distinctly different colors of the type mingled together....

  1. 7 CFR 29.1035 - Mixed color (KM).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Mixed color (KM). 29.1035 Section 29.1035 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1035 Mixed color (KM). Distinctly different colors of the type mingled together....

  2. 7 CFR 29.1035 - Mixed color (KM).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed color (KM). 29.1035 Section 29.1035 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1035 Mixed color (KM). Distinctly different colors of the type mingled together....

  3. 7 CFR 29.1035 - Mixed color (KM).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Mixed color (KM). 29.1035 Section 29.1035 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1035 Mixed color (KM). Distinctly different colors of the type mingled together....

  4. Role of the transition zone and 660 km discontinuity in mantle dynamics

    NASA Astrophysics Data System (ADS)

    Ringwood, A. E.

    1994-10-01

    of differentiated oceanic lithosphere, with discrete lithological domains of former oceanic crust, former harzburgite and former lherzolite. However, in the upper mantle, these lithologies have been homogenized via convective mixing and partial melting to form a uniform pyrolite composition. Seismic velocity gradients in the heterogeneous mixture of lithologies of the transition zone are higher than they would be in homogeneous pyrolite, because of the survival of clinopyroxene to a depth of about 500 km. This may contribute towards high seismic velocity gradients observed in the transition zone. The behavior during partial melting of heterogeneous lithologies from the transition zone is also quite different from the partial melting of homogeneous pyrolite. The transition zone provides the principal source region for alkaline intraplate basalts world-wide (including ocean island basalts) whereas the homogeneous pyrolite source region of the upper mantle yields mid-ocean ridge basalt magmas.

  5. Exploring KM Features of High-Performance Companies

    NASA Astrophysics Data System (ADS)

    Wu, Wei-Wen

    2007-12-01

    For reacting to an increasingly rival business environment, many companies emphasize the importance of knowledge management (KM). It is a favorable way to explore and learn KM features of high-performance companies. However, finding out the critical KM features of high-performance companies is a qualitative analysis problem. To handle this kind of problem, the rough set approach is suitable because it is based on data-mining techniques to discover knowledge without rigorous statistical assumptions. Thus, this paper explored KM features of high-performance companies by using the rough set approach. The results show that high-performance companies stress the importance on both tacit and explicit knowledge, and consider that incentives and evaluations are the essentials to implementing KM.

  6. Marshall Space Flight Center Propulsion Systems Department (PSD) KM Initiative

    NASA Technical Reports Server (NTRS)

    Caraccioli, Paul; Varnadoe, Tom; McCarter, Mike

    2006-01-01

    NASA Marshall Space Flight Center s Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities with in the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center Of Excellence (AISCE), Intergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KM implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to support the planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have been performed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural/KM surveys and practitioner interviews include

  7. Hysteretic Behavior of Proprotein Convertase 1/3 (PC1/3)

    PubMed Central

    Icimoto, Marcelo Y.; Barros, Nilana M.; Ferreira, Juliana C.; Marcondes, Marcelo F.; Andrade, Douglas; Machado, Mauricio F.; Juliano, Maria A.; Júdice, Wagner A.; Juliano, Luiz; Oliveira, Vitor

    2011-01-01

    The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a lag phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis. This is an unprecedented observation in peptidases, but is frequent in regulatory enzymes with physiological relevance. The lag phase of mPC1/3 is dependent on substrate, calcium concentration and pH. This hysteretic behavior may have implications in the physiological processes in which PC1/3 participates and could be considered an additional control step in the peptide hormone maturation processes as for instance in the transformation of proinsulin to insulin. PMID:21935423

  8. Faraday laser using 1.2 km fiber as an extended cavity

    NASA Astrophysics Data System (ADS)

    Tao, Zhiming; Zhang, Xiaogang; Pan, Duo; Chen, Mo; Zhu, Chuanwen; Chen, Jingbiao

    2016-07-01

    We demonstrate a Faraday laser using a 1.2 km fiber as an extended cavity, which provides optical feedback and obtains small free spectrum range (FSR) of 83 kHz, and have succeeded in limiting the laser frequency to a crossover transition {5}2{S}1/2,F=2\\to {5}2{P}3/2,F\\prime =1,3 of the natural 87Rb at 780 nm. The Faraday laser is based on a Faraday anomalous dispersion optical filter (FADOF) with an ultra-narrow bandwidth and the long fiber extended cavity of 1.2 km. The peak transmission assigned to the crossover transition F=2\\to F\\prime =1,3 in the FADOF is 20.5% with an ultra-narrow bandwidth of 29.1 MHz. The Allan deviation of the Faraday laser is around 6.0× {10}-11 in 0.06 to 1 s sampling time. Laser frequency is always kept in the center of the transmitted peak assigned to F=2\\to F\\prime =1,3. The Faraday laser realized here can provide light exactly resonant with an atomic transition used for atom-photon interaction experiments and is insensitive to diode temperature and injection current fluctuations.

  9. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5 ...

    EPA Pesticide Factsheets

    The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the RDX assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website. EPA is undertaking an update of the Integrated Risk Information System (IRIS) health assessment for RDX. The outcome of this project is an updated Toxicological Review and IRIS Summary for RDX that will be entered into the IRIS database.

  10. Association between immunoglobulin GM and KM genotypes and placental malaria in HIV-1 negative and positive women in western Kenya.

    PubMed

    Iriemenam, Nnaemeka C; Pandey, Janardan P; Williamson, John; Blackstock, Anna J; Yesupriya, Ajay; Namboodiri, Aryan M; Rocca, Keith M; van Eijk, Anna Maria; Ayisi, John; Oteino, Juliana; Lal, Renu B; ter Kuile, Feiko O; Steketee, Richard; Nahlen, Bernard; Slutsker, Laurence; Shi, Ya Ping

    2013-01-01

    Immunoglobulin (Ig) GM and KM allotypes, genetic markers of γ and κ chains, are associated with humoral immune responsiveness. Previous studies have shown the relationships between GM6-carrying haplotypes and susceptibility to malaria infection in children and adults; however, the role of the genetic markers in placental malaria (PM) infection and PM with HIV co-infection during pregnancy has not been investigated. We examined the relationship between the gene polymorphisms of Ig GM6 and KM allotypes and the risk of PM infection in pregnant women with known HIV status. DNA samples from 728 pregnant women were genotyped for GM6 and KM alleles using polymerase chain reaction-restriction fragment length polymorphism method. Individual GM6 and KM genotypes and the combined GM6 and KM genotypes were assessed in relation to PM in HIV-1 negative and positive women, respectively. There was no significant effect of individual GM6 and KM genotypes on the risk of PM infection in HIV-1 negative and positive women. However, the combination of homozygosity for GM6(+) and KM3 was associated with decreased risk of PM (adjusted OR, 0.25; 95% CI, 0.08-0.8; P = 0.019) in HIV-1 negative women while in HIV-1 positive women the combination of GM6(+/-) with either KM1-3 or KM1 was associated with increased risk of PM infection (adjusted OR, 2.10; 95% CI, 1.18-3.73; P = 0.011). Hardy-Weinberg Equilibrium (HWE) tests further showed an overall significant positive F(is) (indication of deficit in heterozygotes) for GM6 while there was no deviation for KM genotype frequency from HWE in the same population. These findings suggest that the combination of homozygous GM6(+) and KM3 may protect against PM in HIV-1 negative women while the HIV-1 positive women with heterozygous GM6(+/-) combined with KM1-3 or KM1 may be more susceptible to PM infection. The deficit in heterozygotes for GM6 further suggests that GM6 could be under selection likely by malaria infection.

  11. Evaluating KM Journal Content: An Assessment of Trends (2000-2005)

    DTIC Science & Technology

    2006-03-01

    Creating a KM Systems Thinking Framework...........................................................17 What is a KM-specific Journal...loop Learning ................................................................... 27 Figure 6. Combining KM Frameworks into a KM Systems Thinking Framework...30 Figure 7. KM Systems Thinking Framework .................................................................. 31 Figure 8. Content

  12. High energy neutrino detection with KM3NeT

    NASA Astrophysics Data System (ADS)

    Migliozzi, Pasquale; KM3NeT Collaboration

    2016-05-01

    The KM3NeT Collaboration has started the construction of a next generation high-energy neutrino telescope in the Mediterranean Sea: the largest and most sensitive neutrino research infrastructure. The full KM3NeT detector will be a several cubic kilometres distributed, networked infrastructure. In Italy, off the coast of Capo Passero, and in France, off the coast of Toulon. Thanks to its location in the Northern hemisphere and to its large instrumented volume, KM3NeT will be the optimal instrument to search for neutrinos from the Southern sky and in particular from the Galactic plane, thus making it complementary to IceCube. In this work the technologically innovative component of the detector, the status of construction and the first results from prototypes of the KM3NeT detector will be described as well as its capability to discover neutrino sources are reported.

  13. Akeno 20 km (2) air shower array (Akeno Branch)

    NASA Technical Reports Server (NTRS)

    Teshima, M.; Ohoka, H.; Matsubara, Y.; Hara, T.; Hatano, Y.; Hayashida, N.; He, C. X.; Honda, M.; Ishikawa, F.; Kamata, K.

    1985-01-01

    As the first stage of the future huge array, the Akeno air shower array was expanded to about 20 sq. km. by adding 19 scintillation detectors of 2.25 sq m area outside the present 1 sq. km. Akeno array with a new data collection system. These detectors are spaced about 1km from each other and connected by two optical fiber cables. This array has been in partial operation from 8th, Sep. 1984 and full operation from 20th, Dec. 1984. 20 sq m muon stations are planned to be set with 2km separation and one of them is now under construction. The origin of the highest energy cosmic rays is studied.

  14. How does music aid 5 km of running?

    PubMed

    Bigliassi, Marcelo; León-Domínguez, Umberto; Buzzachera, Cosme F; Barreto-Silva, Vinícius; Altimari, Leandro R

    2015-02-01

    This research investigated the effects of music and its time of application on a 5-km run. Fifteen well-trained male long-distance runners (24.87 ± 2.47 years; 78.87 ± 10.57 kg; 178 ± 07 cm) participated in this study. Five randomized experimental conditions during a 5-km run on an official track were tested (PM: motivational songs, applied before 5 km of running; SM: slow motivational songs, applied during 5 km of running; FM: fast and motivational songs, applied during 5 km of running; CS: calm songs, applied after 5 km of running; CO: control condition). Psychophysiological assessments were performed before (functional near-infrared spectroscopy, heart rate variability [HRV], valence, and arousal), during (performance time, heart rate, and rate of perceived exertion [RPE]), and after (mood, RPE, and HRV) tests. The chosen songs were considered pleasurable and capable of activating. Furthermore, they activated the 3 assessed prefrontal cortex (PFC) areas (medial, right dorsolateral, and left dorsolateral) similarly, generating positive emotional consequences by autonomous system analysis. The first 800 m was accomplished faster for SM and FM compared with other conditions (p ≤ 0.05); moreover, there was a high probability of improving running performance when music was applied (SM: 89%; FM: 85%; PM: 39%). Finally, music was capable of accelerating vagal tonus after 5 km of running with CS (p ≤ 0.05). In conclusion, music was able to activate the PFC area, minimize perceptions, improve performance, and accelerate recovery during 5 km of running.

  15. Exploration of cultivable fungal communities in deep coal-bearing sediments from ∼1.3 to 2.5 km below the ocean floor.

    PubMed

    Liu, Chang-Hong; Huang, Xin; Xie, Tian-Ning; Duan, Ning; Xue, Ya-Rong; Zhao, Tan-Xi; Lever, Mark A; Hinrichs, Kai-Uwe; Inagaki, Fumio

    2017-02-01

    Although subseafloor sediments are known to harbour a vast number of microbial cells, the distribution, diversity, and origins of fungal populations remain largely unexplored. In this study, we cultivated fungi from 34 of 47 deep coal-associated sediment samples collected at depths ranging from 1289 to 2457 m below the seafloor (mbsf) off the Shimokita Peninsula, Japan (1118 m water depth). We obtained a total of 69 fungal isolates under strict contamination controls, representing 61 Ascomycota (14 genera, 23 species) and 8 Basidiomycota (4 genera, 4 species). Penicillium and Aspergillus relatives were the most dominant genera within the Ascomycetes, followed by the members of genera Cladosporium, Hamigera, Chaetomium, Eutypella, Acremonium, Aureobasidium, Candida, Eurotium, Exophiala, Nigrospora, Bionectria and Pseudocercosporella. Four Basidiomycota species were identified as genera Schizophyllum, Irpex, Bjerkandera and Termitomyces. Among these isolates, Cladosporium sphaerospermum and Aspergillus sydowii relatives were isolated from a thin lignite coal-sandstone formation at 2457 mbsf. Our results indicate that these cultivable fungal populations are indigenous, originating from past terrigenous environments, which have persisted, possibly as spores, through ∼20 million years of depositional history.

  16. Comparison of Two Fluid Replacement Protocols During a 20-km Trail Running Race in the Heat.

    PubMed

    Lopez, Rebecca M; Casa, Douglas J; Jensen, Katherine A; Stearns, Rebecca L; DeMartini, Julie K; Pagnotta, Kelly D; Roti, Melissa W; Armstrong, Lawrence E; Maresh, Carl M

    2016-09-01

    Lopez, RM, Casa, DJ, Jensen, K, Stearns, RL, DeMartini, JK, Pagnotta, KD, Roti, MW, Armstrong, LE, and Maresh, CM. Comparison of two fluid replacement protocols during a 20-km trail running race in the heat. J Strength Cond Res 30(9): 2609-2616, 2016-Proper hydration is imperative for athletes striving for peak performance and safety, however, the effectiveness of various fluid replacement strategies in the field setting is unknown. The purpose of this study was to investigate how two hydration protocols affect physiological responses and performance during a 20-km trail running race. A randomized, counter-balanced, crossover design was used in a field setting (mean ± SD: WBGT 28.3 ± 1.9° C). Well-trained male (n = 8) and female (n = 5) runners (39 ± 14 years; 175 ± 9 cm; 67.5 ± 11.1 kg; 13.4 ± 4.6% BF) completed two 20-km trail races (5 × 4-km loop) with different water hydration protocols: (a) ad libitum (AL) consumption and (b) individualized rehydration (IR). Data were analyzed using repeated measures ANOVA. Paired t-tests compared pre-race-post-race measures. Main outcome variables were race time, heart rate (HR), gastrointestinal temperature (TGI), fluid consumed, percent body mass loss (BML), and urine osmolality (Uosm). Race times between groups were similar. There was a significant condition × time interaction (p = 0.048) for HR, but TGI was similar between conditions. Subjects replaced 30 ± 14% of their water losses in AL and 64 ± 16% of their losses in IR (p < 0.001). Ad libitum trial experienced greater BML (-2.6 ± 0.5%) compared with IR (-1.3 ± 0.5%; p < 0.001). Pre-race to post-race Uosm differences existed between AL (-273 ± 146 mOsm) and IR (-145 ± 215 mOsm, p = 0.032). In IR, runners drank twice as much fluid than AL during the 20-km race, leading to > 2% BML in AL. Ad libitum drinking resulted in 1.3% greater BML over the 20-km race, which resulted in no thermoregulatory or performance differences from IR.

  17. Structural and thermal stabilities of layered Li(Ni 1/3Co 1/3Mn 1/3)O 2 materials in 18650 high power batteries

    NASA Astrophysics Data System (ADS)

    He, Yan-Bing; Ning, Feng; Yang, Quan-Hong; Song, Quan-Sheng; Li, Baohua; Su, Fangyuan; Du, Hongda; Tang, Zhi-Yuan; Kang, Feiyu

    The structural and thermal stabilities of the layered Li(Ni 1/3Co 1/3Mn 1/3)O 2 cathode materials under high rate cycling and abusive conditions are investigated using the commercial 18650 Li(Ni 1/3Co 1/3Mn 1/3)O 2/graphite high power batteries. The Li(Ni 1/3Co 1/3Mn 1/3)O 2 materials maintain their layered structure even when the power batteries are subjected to 200 cycles with 10 C discharge rate at temperatures of 25 and 50 °C, whereas their microstructure undergoes obvious distortion, which leads to the relatively poor cycling performance of power batteries at high charge/discharge rates and working temperature. Under abusive conditions, the increase in the battery temperature during overcharge is attributed to both the reactions of electrolyte solvents with overcharged graphite anode and Li(Ni 1/3Co 1/3Mn 1/3)O 2 cathode and the Joule heat that results from the great increase in the total resistance (R cell) of batteries. The reactions of fully charged Li(Ni 1/3Co 1/3Mn 1/3)O 2 cathodes and graphite anodes with electrolyte cannot be activated during short current test in the fully charged batteries. However, these reactions occur at around 140 °C in the fully charged batteries during oven test, which is much lower than the temperature of about 240 °C required for the reactions outside batteries.

  18. Bis(1,3-dimethyl-1,3-diazinan-2-one)dinitratodioxidouranium(VI)

    PubMed Central

    Suzuki, Tomoya; Kawasaki, Takeshi; Ikeda, Yasuhisa

    2011-01-01

    The title compound, [U(NO3)2O2(C6H12N2O)2], exhibits a hexa­gonal–bipyramidal geometry around the UVI ion, which is situated on an inversion centre and coordinated by two oxide ligands in the axial positions, and four O atoms from two bidentate NO3 − and two O atoms from two 1,3-dimethyl-1,3-diazinan-2-one (DMPU) ligands in the equatorial plane. These ligands are located in trans positions. The –(CH2)3– moiety in the DMPU ligand is disordered over two positions in a 0.786 (11):0.214 (11) ratio. PMID:21522544

  19. Biodegradation of 1,3,5-trinitro-1,3,5-triazine (RDX).

    PubMed

    Lee, Sheng-Yih; Brodman, Bruce W

    2004-01-01

    Two bacteria were isolated from 1,3,5-trinitro-1,3,5-triazine (RDX) contaminated soil at Picatinny Arsenal, New Jersey. These organisms were subsequently identified as Rhiziobium rhizogenes BL and Burkholderia sp.BL by the Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ, German Collection of Microorganisms and Cell Cultures). In addition a fungus, identified as Cladosporium cladosporioides by DSMZ, was found to be growing on water wet RDX. All of these organisms were found to degrade RDX. The two bacteria were found to represent new species that have not been reported before. It was found that these organisms along with an added carbon source could degrade RDX to simple gaseous products. Data are presented that elucidate the mechanisms of RDX biodegradation for these organisms.

  20. Synthesis of planar chiral ferrocenyl 1,3-diamines and 1,3-amino ethers.

    PubMed

    Anderson, James C; Blake, Alexander J; Arnall-Culliford, Jennifer C

    2003-10-21

    The efficient syntheses of novel planar chiral 1,3-diamines and 1,3-amino ethers with an oxy or amino function directly bound to the cyclopentadienyl ring of ferrocene has been developed. The key reaction is the Cu2O promoted substitution of (pR)-N,N-diisopropyl-2-iodoferrocenecarboxamide with either phthalimide or AcOH to introduce nitrogen or oxygen functionality onto the cyclopentadienyl ring. The enantiomerically pure iodoferrocene derivative is available from the known enantioselective ortho-lithiation of N,N-diisopropylferrocenecarboxamide with n-BuLi-sparteine. In the course of these studies the synthesis of a novel C2 symmetric C-2 dimer of N,N-dimethyl-1-ferrocenylethylamine was characterised by single crystal X-ray diffraction.

  1. Local fluctuations of ozone from 16 km to 45 km deduced from in situ vertical ozone profile

    NASA Technical Reports Server (NTRS)

    Moreau, G.; Robert, C.

    1994-01-01

    A vertical ozone profile obtained by an in situ ozone sonde from 16 km to 45 km, has allowed to observe local ozone concentration variations. These variations can be observed, thanks to a fast measurement system based on a UV absorption KrF excimer laser beam in a multipass cell. Ozone standard deviation versus altitude calculated from the mean is derived. Ozone variations or fluctuations are correlated with the different dynamic zones of the stratosphere.

  2. Detection of the structure near the 410 km and 660 km discontinuities in Japan subduction zone from the waveform triplication

    NASA Astrophysics Data System (ADS)

    Cui, H.; Zhou, Y.

    2015-12-01

    Slab subduction plays an important role in the mantle material circulation [Stern, 2002], and can also affect the feature of the 410 km and 660 km seismic discontinuities (410 and 660) [Lebedev et al., 2002]. Japan subduction zone is a natural laboratory for studying the mantle composition and velocity structure associated with the deep subduction of the Pacific plate. In this study, triplicated waveforms of an intermediate-depth earthquake at the Hokkaido of Japan (2011/10/21, 08:02:37.62, 142.5315°E, 43.8729°N, Mb6.0, relocated depth: 188 km) are retrieved from the dense Chinese Digital Seismic Network (CDSN). P and S waveforms are filtered with the band of 0.05-1.0 Hz and 0.02-0.5 Hz, respectively, and then integrated into the displacement data. The relative traveltime and synthetic waveform fitting is applied to mapping the deep structure. The best fitting models are obtained through the trial and error tests. We find a 15 km uplift of the 410 and a 25 km depression of the 660, indicating the cold environment caused by the subduction slab; both the 410 and 660 show the sharp discontinuity, but a smaller velocity contrast than the IASP91 model [Kennett and Engdahl, 1991]. Atop the 410 and 660, there are high-velocity layers associated with the subduction (or stagnant) slab. We also find a low-velocity anomaly with the thickness of ~65 km below the 660, which may relate to the slab dehydration or the hot upwelling at the top of the lower mantle. The seismic velocity ratio (VP/VS) shows a lower zone at the depth of ~210-395 km, showing the consistency with the low Poisson's ratio signature of the oceanic plate; a higher zone at the depth of ~560-685 km, implying the hydrous mantle transition zone.

  3. Gravity Waves Near 300 km Over the Polar Caps

    NASA Technical Reports Server (NTRS)

    Johnson, F. S.; Hanson, W. B.; Hodges, R. R.; Coley, W. R.; Carignan, G. R.; Spencer, N. W.

    1995-01-01

    Distinctive wave forms in the distributions of vertical velocity and temperature of both neutral particles and ions are frequently observed from Dynamics Explorer 2 at altitudes above 250 km over the polar caps. These are interpreted as being due to internal gravity waves propagating in the neutral atmosphere. The disturbances characterized by vertical velocity perturbations of the order of 100 m/s and horizontal wave lengths along the satellite path of about 500 km. They often extend across the entire polar cap. The associated temperature perturbations indicate that the horizontal phase progression is from the nightside to the dayside. Vertical displacements are inferred to be of the order of 10 km and the periods to be of the order of 10(exp 3) s. The waves must propagate in the neutral atmosphere, but they usually are most clearly recognizable in the observations of ion vertical velocity and ion temperature. By combining the neutral pressure calculated from the observed neutral concentration and temperature with the vertical component of the neutral velocity, an upward energy flux of the order of 0.04 erg/sq cm-s at 250 km has been calculated, which is about equal to the maximum total solar ultraviolet heat input above that altitude. Upward energy fluxes calculated from observations on orbital passes at altitudes from 250 to 560 km indicate relatively little attenuation with altitude.

  4. The KM3NeT Digital Optical Module

    NASA Astrophysics Data System (ADS)

    Vivolo, Daniele

    2016-04-01

    KM3NeT is a European deep-sea multidisciplinary research infrastructure in the Mediterranean Sea. It will host a km3-scale neutrino telescope and dedicated instruments for long-term and continuous measurements for Earth and Sea sciences. The KM3NeT neutrino telescope is a 3-dimensional array of Digital Optical Modules, suspended in the sea by means of vertical string structures, called Detection Units, supported by two pre-stretched Dyneema ropes, anchored to the seabed and kept taut with a system of buoys. The Digital Optical Module represents the active part of the neutrino telescope. It is composed by a 17-inch, 14 mm thick borosilicate glass (Vitrovex) spheric vessel housing 31 photomultiplier tubes with 3-inch photocathode diameter and the associated front-end and readout electronics. The technical solution adopted for the KM3NeT optical modules is characterized by an innovative design, considering that existing neutrino telescopes, Baikal, IceCube and ANTARES, all use large photomultipliers, typically with a diameter of 8″ or 10″. It offers several advantages: higher sensitive surface (1260 cm2), weaker sensitivity to Earth's magnetic field, better distinction between single-photon and multi-photon events (photon counting) and directional information with an almost isotropic field of view. In this contribution the design and the performance of the KM3NeT Digital Optical Modules are discussed, with a particular focus on enabling technologies and integration procedure.

  5. Synchrotron radiation-based 61Ni Mössbauer spectroscopic study of Li(Ni1/3Mn1/3Co1/3)O2 cathode materials of lithium ion rechargeable battery

    NASA Astrophysics Data System (ADS)

    Segi, Takashi; Masuda, Ryo; Kobayashi, Yasuhiro; Tsubota, Takayuki; Yoda, Yoshitaka; Seto, Makoto

    2016-12-01

    Layered rocksalt type oxides, such as Li(Ni1/3Mn1/3Co1/3)O2, are widely used as the cathode active materials of lithium-ion rechargeable batteries. Because the nickel ions are associated with the role of the charge compensation at discharge and charge, the 61Ni Mössbauer measurements at 6 K using synchrotron radiation were performed to reveal the role of Ni. The Ni ions of the active materials play two roles for the redox process between the charge and discharge states of lithium-ion batteries. Half of the total Ni ions change to the low-spin Ni3+ with Jahn-Teller distortion from the Ni2+ ions of the discharge state. The remainder exhibit low-spin state divalent Ni ions.

  6. Reliability of 5-km Running Performance in a Competitive Environment

    ERIC Educational Resources Information Center

    Hurst, Philip; Board, Lisa

    2017-01-01

    The aim of this study was to examine the reliability of a 5-km time-trial during a competitive outdoor running event. Fifteen endurance runners (age = 29.5 ± 4.3 years, height = 1.75 ± 0.08 m, body mass = 71.0 ± 7.1 kg, 5-km lifetime personal best = 19:13 ± 1:13 minutes) completed two competitive 5-km time-trials over 2 weeks. No systematic…

  7. Simulation of CO2 release at 800 km altitude

    NASA Astrophysics Data System (ADS)

    Setayesh, A.

    1993-08-01

    The SOCRATES contamination-interaction code has been used to simulate the reactions of 0 + CO2 yields CO2(v) + O, O + CO2 - CO(v) + O2, and CO2 + H - CO + OH(v) at an altitude of 800 km in both ram and wake directions of the spacecraft. These simulations show that the radiation from these reactions can be measurable for the parameters which have been used in these calculations. The investigation carries out the simulations as much as 30 km from the spacecraft. The radiative intensity of CO(v) and OH(v) show the highest and lowest, respectively.

  8. Digital optical module electronics of KM3NeT

    NASA Astrophysics Data System (ADS)

    Real, D.; Calvo, D.

    2016-11-01

    The KM3NeT neutrino telescope is being built on the Mediterranean sea and, once completed, it will be composed by tens of thousands of glass spheres (nodes) including each 31 of small photocathode (3"). The readout and data acquisition system of KM3NeT has to collect, treat and send to shore, in an economic way, the enormous amount of data produced by the photomultipliers and at the same time to provide time synchronization between each node at the level of 1 ns. It is described in the present article all the electronics developed for achieving this goal.

  9. Cascade sensitivity studies for KM3NeT

    NASA Astrophysics Data System (ADS)

    Fusco, Luigi Antonio

    2016-07-01

    KM3NeT is a future research infrastructure in the deep seas of the Mediterranean housing a large scale neutrino telescope. The first phase of construction of the telescope has started. Next step is an intermediate phase realising a detector volume of about one-third of the final detector volume. We report on calculations of the sensitivity of the KM3NeT detector to showering neutrino events, the strategy to optimise the detector to a cosmic neutrino flux analogous to the one reported by the IceCube Collaboration and the results of this strategy applied to the intermediate phase detector.

  10. Neutral winds above 200Km at high latitudes

    NASA Technical Reports Server (NTRS)

    Meriwether, J. W.; Heppner, J. P.; Stolarik, J. D.; Wescott, E. M.

    1972-01-01

    Motion from multiple chemical releases between 200 and 300 km from 15 rockets launched from 4 high latitude locations are analyzed. The observations in the evening and midnight hours at magnetic altitudes or = 65 deg suggest that in these regions ion drag is the dominant force in driving neutral winds between 200 and 300 km. This conclusion is based on both the agreement between ion and neutral drift directions, and the fact that there are distinct changes in the wind associated with (a) the reversal in east-west ion drift at the Harang discontinuity, and (b) the transition from auroral belt, sunward ion drift and polar cap, anti-solar ion drift.

  11. Preparation, characterization of LiNi{sub 1/3}Mn{sub 1/3}Co{sub 1/3}O{sub 2} film cathode.

    SciTech Connect

    Kang, S. H.; Abraham, D. P.; Chemical Engineering

    2006-01-01

    Positive electrodes based on the LiNi{sub 1/3}Mn{sub 1/3}Co{sub 1/3}O{sub 2} material are being evaluated in high-power lithium-ion cells for hybrid-electric vehicle applications. To determine performance degradation mechanisms that are associated with the active material, we prepared carbon- and binder-free LiNi{sub 1/3}Mn{sub 1/3}Co{sub 1/3}O{sub 2} film cathode on a Pt substrate using a sol-gel spin coating technique. The material was characterized by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy. Initial data from cyclic voltammetry, galvanostatic cycling, and electrochemical impedance spectroscopy measurements conducted on the electrodes are reported.

  12. Electrochemical characteristics of layered LiNi 1/3Co 1/3Mn 1/3O 2 and with different synthesis conditions

    NASA Astrophysics Data System (ADS)

    He, Ping; Wang, Haoran; Qi, Lu; Osaka, Tetsuya

    LiNi 1/3Mn 1/3Co 1/3O 2 had been successfully prepared from spherical composite carbonate via a simple uniform-phase precipitation method [P. He, H. Wang, L. Qi, T. Osaka, J. Power Sources, in press] at normal pressure, using nickel, cobalt and manganese sulfate and ammonia bicarbonate as reactants. The preparation of spherical composite carbonate was significantly dependant on synthetic condition, such as the reaction temperature, feed rate, molar ratio of these reactants, etc. The optimized condition resulted in spherical composite carbonate of which the particle size distribution was uniform, as observed by scanning electronic microscopy (SEM). Calcination of the uniform composite carbonate with lithium carbonate at high temperature led to a well-ordered layer structured LiNi 1/3Mn 1/3Co 1/3O 2 as confirmed by X-ray diffraction (XRD), without obvious change in shape. Due to the homogeneity of the composite carbonate, the final product, LiNi 1/3Mn 1/3Co 1/3O 2, was also significantly uniform, i.e., the average particle size was of about 10 μm in diameter and the distribution was relatively narrow. As a result, the corresponding tap density was also high, approximately 2.32 g cm -3, of which the value is very near to that of commercialized LiCoO 2. In the voltage range of 2.8-4.2, 2.8-4.35 and 2.8-4.5 V, the discharge capacities of LiNi 1/3Mn 1/3Co 1/3O 2 electrode were 159, 168 and 179 mAh g -1, respectively, with good cyclability.

  13. Short and general procedure for synthesizing cis-1,2-fused 1,3-oxathiolan-, 1,3-oxaselenolan-, and 1,3-oxazolidin-2-imine carbohydrate derivatives.

    PubMed

    Castilla, Javier; Marín, Irene; Matheu, M Isabel; Díaz, Yolanda; Castillón, Sergio

    2010-01-15

    Novel cis-1,2-fused 1,3-oxathiolan-, 1,3-oxaselenolan-, and 1,3-oxazolidin-2-imine carbohydrate derivatives have been prepared by treatment of the corresponding 1,2-anhydrosugars with potassium thiocyanate, potassium selenocyanate, and sodium cyanamide, respectively. The procedure is compatible with several protecting groups such as acyl, benzyl, and silyl and also with sugars of different configurations.

  14. Seismic evidence for silicate melt atop the 410-km mantle discontinuity

    USGS Publications Warehouse

    Revenaugh, Justin; Sipkin, S.A.

    1994-01-01

    LABORATORY results demonstrating that basic to ultrabasic melts become denser than olivine-rich mantle at pressures above 6 GPa (refs 1-3) have important implications for basalt petrogenesis, mantle differentiation and the storage of volatiles deep in the Earth. A density cross-over between melt and solid in the extensively molten Archaean mantle has been inferred from komatiitic volcanism and major-element mass balances, but present-day evidence of dense melt below the seismic low-velocity zone is lacking. Here we present mantle shear-wave impedance profiles obtained from multiple-ScS reverberation mapping for corridors connecting western Pacific subduction zone earthquakes with digital seismograph stations in eastern China, imaging a ~5.8% impedance decrease roughly 330 km beneath the Sea of Japan, Yellow Sea and easternmost Asia. We propose that this represents the upper surface of a layer of negatively buoyant melt lying on top of the olivine ??? ??- phase transition (the 410-km seismic discontinuity). Volatile-rich fluids expelled from the partial melt zone as it freezes may migrate upwards, acting as metasomatic agents and perhaps as the deep 'proto-source' of kimberlites. The remaining, dense, crystalline fraction would then concentrate above 410 km, producing a garnet-rich layer that may flush into the transition zone.

  15. Seismic evidence for silicate melt atop the 410-km mantle discontinuity

    NASA Astrophysics Data System (ADS)

    Revenaugh, J.; Sipkin, S. A.

    1994-06-01

    LABORATORY results demonstrating that basic to ultrabasic melts become denser than olivine-rich mantle at pressures above 6 GPa (refs 1-3) have important implications for basalt petrogenesis, mantle differentiation and the storage of volatiles deep in the Earth. A density cross-over between melt and solid in the extensively molten Archaean mantle has been inferred from komatiitic volcanism4-6 and major-element mass balances7, but present-day evidence of dense melt below the seismic low-velocity zone is lacking. Here we present mantle shear-wave impedance profiles obtained from multiple-ScS reverberation mapping for corridors connecting western Pacific subduction zone earthquakes with digital seismograph stations in eastern China, imaging a ~5.8% impedance decrease roughly 330 km beneath the Sea of Japan, Yellow Sea and easternmost Asia. We propose that this represents the upper surface of a layer of negatively buoyant melt lying on top of the olivine-->β-phase transition (the 410-km seismic discontinuity). Volatile-rich fluids expelled from the partial melt zone as it freezes may migrate upwards, acting as metasomatic agents8,9 and perhaps as the deep 'proto-souree' of kimberlites10,11. The remaining, dense, crystalline fraction would then concentrate above 410 km, producing a garnet-rich layer that may flush into the transition zone.

  16. Water quality criteria for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).

    PubMed

    Etnier, E L

    1989-04-01

    The occurrence of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater surrounding Army ammunition plants may result in contamination of local drinking water supplies. RDX exerts its primary toxic effect in humans on the central nervous system, but also involves gastrointestinal and renal effects. Symptomatic effects following acute exposure include hyperirritability, nausea, vomiting, generalized epileptiform seizures, and prolonged postictal confusion and amnesia. Health effects data were analyzed for RDX, and although no controlled human studies exist concerning the acute or chronic toxic effects of exposure to RDX, sufficient animal toxicity data are available to derive an ambient water quality criterion for the protection of human health. This paper summarizes the available literature on metabolism of RDX and human and animal toxicity. Based on noncarcinogenic mammalian toxicity data, and following the methodologies of the U.S. Environmental Protection Agency, an ambient water quality criterion for the protection of human health of 103 micrograms/liter is proposed for ingestion of drinking water and aquatic foodstuffs. A criterion of 105 micrograms/liter is proposed for ingestion of drinking water alone.

  17. Water quality criteria for hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    SciTech Connect

    Etnier, E.L.

    1989-04-01

    The occurrence of the munitions compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in groundwater surrounding Army ammunition plants may result in contamination of local drinking water supplies. RDX exerts its primary toxic effect in humans on the central nervous system, but also involves gastrointestinal and renal effects. Symptomatic effects following acute exposure include hyperirritability, nausea, vomiting, generalized epileptiform seizures, and prolonged postictal confusion and amnesia. Health effects data were analyzed for RDX, and although no controlled human studies exist concerning the acute or chronic toxic effects of exposure to RDX, sufficient animal toxicity data are available to derive an ambient water quality criterion for the protection of human health. This paper summarizes the available literature on metabolism of RDX and human and animal toxicity. Based on noncarcinogenic mammalian toxicity data, and following the methodologies of the U.S. Environmental Protection Agency, an ambient water quality criterion for the protection of human health of 103 micrograms/liter is proposed for ingestion of drinking water and aquatic foodstuffs. A criterion of 105 micrograms/liter is proposed for ingestion of drinking water alone.54 references.

  18. Running economy during a simulated 60-km trial.

    PubMed

    Schena, Federico; Pellegrini, Barbara; Tarperi, Cantor; Calabria, Elisa; Salvagno, Gian Luca; Capelli, Carlo

    2014-07-01

    The effect of a prolonged running trial on the energy cost of running (C(r)) during a 60-km ultramarathon simulation at the pace of a 100-km competition was investigated in 13 men (40.8 ± 5.6 y, 70.7 ± 5.5 kg, 177.5 ± 4.5 cm) and 5 women (40.4 ± 2.3 y, 53.7 ± 4.4 kg, 162.4 ± 4.8 cm) who participated in a 60-km trial consisting of 3 consecutive 20-km laps. Oxygen uptake (VO(2)) at steady state was determined at constant speed before the test and at the end of each lap; stride length (SL) and frequency and contact time were measured at the same time points; serum creatine kinase (S-CPK) was measured before and at the end of the test. C(r) in J · kg(-1) · m(-1), as calculated from VO(2ss) and respiratory-exchange ratio, did not increase with distance. SL significantly decreased with distance. The net increase in S-CPK was linearly related with the percentage increase of C(r) observed during the trial. It is concluded that, in spite of increased S-CPK, this effort was not able to elicit any peripheral or central fatigue or biomechanical adaptation leading to any modification of C(r).

  19. Gravity wave vertical energy flux at 95 km

    NASA Technical Reports Server (NTRS)

    Jacob, P. G.; Jacka, F.

    1985-01-01

    A three-field photometer (3FP) located at Mt. Torrens near Adelaide, is capable of monitoring different airglow emissions from three spaced fields in the sky. A wheel containing up to six different narrow bandpass interference filters can be rotated, allowing each of the filters to be sequentially placed into each of the three fields. The airglow emission of interest is the 557.7 nm line which has an intensity maximum at 95 km. Each circular field of view is located at the apexes of an equilateral triangle centered on zenith with diameters of 5 km and field separations of 13 km when projected to the 95-km level. The sampling period was 30 seconds and typical data lengths were between 7 and 8 hours. The analysis and results from the interaction of gravity waves on the 557.7 nm emission layer are derived using an atmospheric model similar to that proposed by Hines (1960) where the atmosphere is assumed isothermal and perturbations caused by gravity waves are small and adiabatic, therefore, resulting in linearized equations of motion. In the absence of waves, the atmosphere is also considered stationary. Thirteen nights of quality data from January 1983 to October 1984, covering all seasons, are used in this analysis.

  20. Body Composition Measurements of 161-km Ultramarathon Participants

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study compares body composition characteristics with performance among participants in a 161-km trail ultramarathon. Height, mass, and percent body fat from bioimpedence spectroscopy were measured on 72 starters. Correlation analyses were used to compare body characteristics with finish time, ...

  1. Models of earth's atmosphere (90 to 2500 km)

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This monograph replaces a monograph on the upper atmosphere which was a computerized version of Jacchia's model. The current model has a range from 90 to 2500 km. In addition to the computerized model, a quick-look prediction method is given that may be used to estimate the density for any time and spatial location without using a computer.

  2. Estimation of terrestrial carbon fluxes with 1km by 1km spatial-resolution using satellite- driven model

    NASA Astrophysics Data System (ADS)

    Sasai, T.; Nasahara, K.; Ito, A.; Saigusa, N.; Hirata, R.; Takagi, K.; Oikawa, T.

    2008-12-01

    Terrestrial carbon cycle is strongly affected by some local natural phenomena and human-induced activities, which bring change to the carbon exchanges via vegetation and soil microbe activities. In order to accurately understand a realistic spatial pattern in carbon exchanges including such an effect of local-scale events, we need to calculate carbon fluxes and storages with as detailed spatial resolution as possible. In response to this, we attempt to estimate terrestrial carbon fluxes with 1km by 1km spatial resolution using satellite-driven model. Study area of the model estimation is the Further East Asia region, which lies at 30-50 north latitude and 125-150 east longitude. The model is the Biosphere model integrating Eco-physiological And Mechanistic approaches using Satellite data (BEAMS) [Sasai et al., 2005, 2007]. Being aim at simulating terrestrial carbon exchanges under more realistic land surface condition, we applied as many as possible of satellite-observation products such as the standard MODIS, TRMM, and SRTM high-level land products as model inputs. In the model validation, we compared between model estimations and eddy covariance measurements at four flux sites. As a result, a correlation coefficient of the terrestrial carbon fluxes between estimations and measurements were high values, leading up that the model estimations are virtually reasonable. In model analysis, BEAMS was operated with 1km by 1km spatial resolution from 2001 to 2006. Spatial distributions in the annual mean NPP and NEP showed that high values were distributed over the hilly and plateau regions, and they were gradually decreasing towards the urban and high mountain areas, meaning that we could reflect an impact of the local-scale events in the carbon flux estimations. In future, we would extend study area to the East Asia region, and the carbon exchange map with 1km by 1km spatial- resolution is distributed on the website.

  3. 21 CFR 172.712 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Other Specific Usage Additives § 172.712 1,3-Butylene glycol. The food additive 1,3-butylene glycol (CAS... 20740, or may be examined at the Center for Food Safety and Applied Nutrition's Library, Food and...

  4. Carrier phase ambiguity resolution for the Global Positioning System applied to geodetic baselines up to 2000 km

    NASA Technical Reports Server (NTRS)

    Blewitt, Geoffrey

    1989-01-01

    A technique for resolving the ambiguities in the GPS carrier phase data (which are biased by an integer number of cycles) is described which can be applied to geodetic baselines up to 2000 km in length and can be used with dual-frequency P code receivers. The results of such application demonstrated that a factor of 3 improvement in baseline accuracy could be obtained, giving centimeter-level agreement with coordinates inferred by very-long-baseline interferometry in the western United States. It was found that a method using pseudorange data is more reliable than one using ionospheric constraints for baselines longer than 200 km. It is recommended that future GPS networks have a wide spectrum of baseline lengths (ranging from baselines shorter than 100 km to those longer than 1000 km) and that GPS receivers be used which can acquire dual-frequency P code data.

  5. 21 CFR 573.225 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.225 1,3-Butylene glycol. The food additive 1,3-butylene glycol (1,3-butanediol) may... 21 Food and Drugs 6 2014-04-01 2014-04-01 false 1,3-Butylene glycol. 573.225 Section 573.225...

  6. 21 CFR 573.225 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.225 1,3-Butylene glycol. The food additive 1,3-butylene glycol (1,3-butanediol) may... 21 Food and Drugs 6 2012-04-01 2012-04-01 false 1,3-Butylene glycol. 573.225 Section 573.225...

  7. 21 CFR 573.225 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.225 1,3-Butylene glycol. The food additive 1,3-butylene glycol (1,3-butanediol) may... 21 Food and Drugs 6 2013-04-01 2013-04-01 false 1,3-Butylene glycol. 573.225 Section 573.225...

  8. 1,3,2-Dioxaarsolanes. Attempts to synthesize hydrospiroarsoranes

    SciTech Connect

    Gamayurova, V.S.; Niyazov, N.A.

    1986-04-20

    2-Hydroxyalkoxyloxy-1,3,2-dioxaarsolanes were obtained by the interaction of trialkyl arsenites with diols and in the absence of steric hindrance were inclined toward dimerization with the formation of 2,2-ethylenedioxybis(1,3,2-dioxaarsolanes). o-Hydroxyphenylenoxy-benzo-1,3,2-dioxaarsole in solution is in equilibrium with 2-hydro-2,2-spirodibenzo-1,3,2-di-oxaarsoranide.

  9. Separation of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane and 1,3,5-trinitro-1,3,5- triazacyclohexane by molecularly imprinted solid-phase extraction.

    PubMed

    Wang, Jian; Meng, Zi-Hui; Xue, Min; Qiu, Li-Li; Zhang, Chen-Fan

    2017-03-01

    Synthesis of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane and 1,3,5-trinitro-1,3,5-triazacyclohexane by the Bachmann process leads to a mixture of both. The separation of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane and 1,3,5-trinitro-1,3,5-triazacyclohexane from their mixture is difficult because the sizes and physical properties of these homologous compounds are similar. For this purpose, seven molecularly imprinted polymers have been synthesized for each explosive, and a selective solid-phase extraction procedure has been developed. A molecularly imprinted polymer, synthesized with 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane as the template, methacrylic acid as the monomer and trimethylolpropane trimethacrylate as the cross-linking agent in a molar ratio of 1:8:8 showed the best separation capability. A packed cartridge containing this polymer can be reused for 23 solid-phase extraction cycles without repacking, and the total separation capability toward 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane reached 6.81 mg per gram of polymer. 1,3,5-Trinitro-1,3,5-triazacyclohexane was not detected in the separated 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane by high-performance liquid chromatography and vice versa. This newly developed method had the advantages of high recovery (100%) and purity, environmental friendliness, and room temperature operability. This study showed that some molecularly imprinted polymers that cannot absorb target analytes well in the solvent in which the polymers were polymerized might have high-binding capacity for the analytes and show imprinting effects in other solvents.

  10. 49 CFR 1.3 - Exercise of authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Exercise of authority. 1.3 Section 1.3... § 1.3 Exercise of authority. (a) In exercising powers and performing duties delegated by this part or..., the Assistant Secretaries, the Inspector General, and the Administrators exercise the powers...

  11. 49 CFR 1.3 - Exercise of authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Exercise of authority. 1.3 Section 1.3... § 1.3 Exercise of authority. (a) In exercising powers and performing duties delegated by this part or..., the Assistant Secretaries, the Inspector General, and the Administrators exercise the powers...

  12. 49 CFR 1.3 - Exercise of authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Exercise of authority. 1.3 Section 1.3... § 1.3 Exercise of authority. (a) In exercising powers and performing duties delegated by this part or..., the Assistant Secretaries, the Inspector General, and the Administrators exercise the powers...

  13. 14 CFR 1.3 - Rules of construction.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Rules of construction. 1.3 Section 1.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION DEFINITIONS DEFINITIONS AND ABBREVIATIONS § 1.3 Rules of construction. (a) In Subchapters A through K of this chapter,...

  14. 7 CFR 1.3 - Agency implementing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Agency implementing regulations. 1.3 Section 1.3 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.3 Agency implementing regulations. Each agency of the Department shall promulgate regulations setting forth...

  15. 7 CFR 1.3 - Agency implementing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Agency implementing regulations. 1.3 Section 1.3 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.3 Agency implementing regulations. Each agency of the Department shall promulgate regulations setting forth...

  16. 43 CFR 3862.1-3 - Evidence of title.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Evidence of title. 3862.1-3 Section 3862.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Lode Mining Claim Patent Applications § 3862.1-3 Evidence of...

  17. 43 CFR 3862.1-3 - Evidence of title.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Evidence of title. 3862.1-3 Section 3862.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Lode Mining Claim Patent Applications § 3862.1-3 Evidence of...

  18. 43 CFR 3862.1-3 - Evidence of title.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Evidence of title. 3862.1-3 Section 3862.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS Lode Mining Claim Patent Applications § 3862.1-3 Evidence of...

  19. The industrial production and use of 1,3-butadiene.

    PubMed Central

    Morrow, N L

    1990-01-01

    This presentation provides a brief overview of the production and use of 1,3-butadiene in the United States. Starting as a coproduct of ethylene, the 1,3-butadiene monomer is extracted and purified, then transferred to consumers. Major uses of 1,3-butadiene include the manufacture of styrene-butadiene rubber, polybutadiene rubber, and adiponitrile. PMID:2205493

  20. 49 CFR 1.3 - Organization of the Department.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Organization of the Department. 1.3 Section 1.3 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.3 Organization of the Department. (a) The Secretary of Transportation is the head of...

  1. Direct, Regioselective N-Alkylation of 1,3-Azoles.

    PubMed

    Chen, Shuai; Graceffa, Russell F; Boezio, Alessandro A

    2016-01-04

    Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective alkylation of various 1,3-azoles. Counterintuitively, substitution selectively occurred at the more sterically hindered nitrogen atom. Numerous examples are provided, on varying 1,3-azole scaffolds, with yields ranging from 25 to 95%.

  2. 10 CFR 960.3-1-3 - Regionality.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for...

  3. 10 CFR 960.3-1-3 - Regionality.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for...

  4. 10 CFR 960.3-1-3 - Regionality.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for...

  5. 10 CFR 960.3-1-3 - Regionality.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for...

  6. 10 CFR 960.3-1-3 - Regionality.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Regionality. 960.3-1-3 Section 960.3-1-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for...

  7. 1,3-Dipolar cycloaddition-decarboxylation reactions of an azomethine ylide with isatoic anhydrides: formation of novel benzodiazepinones.

    PubMed

    D'Souza, Asha M; Spiccia, Nadia; Basutto, Jose; Jokisz, Pawel; Wong, Leon S-M; Meyer, Adam G; Holmes, Andrew B; White, Jonathan M; Ryan, John H

    2011-02-04

    A nonstabilized azomethine ylide reacts with a wide range of substituted isatoic anhydrides to afford novel 1,3-benzodiazepin-5-one derivatives, which are generally isolated in high yield. The transformations involve 1,3-dipolar cycloaddition reactions of the ylide with the anhydrides to give transient, and in a representative case spectroscopically observable, oxazolidine intermediates that undergo ring-opening-decarboxylation-ring-closing reaction cascades to yield the 1,3-benzodiazepin-5-one products.

  8. Immunoglobulin GM and KM Allotypes and Prevalence of Anti-LKM1 Autoantibodies in Patients with Hepatitis C Virus Infection

    PubMed Central

    Muratori, Paolo; Sutherland, Susan E.; Muratori, Luigi; Granito, Alessandro; Guidi, Marcello; Pappas, Georges; Lenzi, Marco; Bianchi, Francesco B.; Pandey, Janardan P.

    2006-01-01

    GM and KM allotypes—genetic markers of immunoglobulin (Ig) γ and κ chains, respectively—are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P = 0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection. PMID:16641304

  9. A novel thin-layer chromatography method to screen 1,3-propanediol producers.

    PubMed

    Anand, Pinki; Saxena, Rajendra Kumar

    2012-11-01

    To date, there is no established protocol for the screening of 1,3-propanediol producers. The proposed method has a wide applicability to harness the commercial potential of microorganisms which produce 1,3-propanediol as the end product. Glycerol fermentation broth of 50 bacteria spotted on thin-layer chromatography plates and run by appropriate solvent systems followed by colour development using vanillin reagent gave different coloured spots with most of the compounds present in the fermentation broth. The appearance of a purple-coloured spot of 1,3-propanediol with a retention factor (R(f)) of 0.62 forms the basis for the selection of 1,3-propanediol producers. Apart from being a rapid detection system the proposed method is pH independent and its authenticity was reconfirmed by HPLC.

  10. Fact Sheet for KM200 Front-end Electronics

    SciTech Connect

    Ianakiev, Kiril Dimitrov; Iliev, Metodi; Swinhoe, Martyn Thomas

    2015-07-08

    The KM200 device is a versatile, configurable front-end electronics boards that can be used as a functional replacement for Canberra’s JAB-01 boards based on the Amptek A-111 hybrid chip, which continues to be the preferred choice of electronics for large number of the boards in junction boxes of multiplicity counters that process the signal from an array of 3He detectors. Unlike the A-111 chip’s fixed time constants and sensitivity range, the shaping time and sensitivity of the new KM200 can be optimized for demanding applications such as spent fuel, and thus could improve the safeguards measurements of existing systems where the A-111 or PDT electronics does not perform well.

  11. Remote (250 km) Fiber Bragg Grating Multiplexing System

    PubMed Central

    Fernandez-Vallejo, Montserrat; Rota-Rodrigo, Sergio; Lopez-Amo, Manuel

    2011-01-01

    We propose and demonstrate two ultra-long range fiber Bragg grating (FBG) sensor interrogation systems. In the first approach four FBGs are located 200 km from the monitoring station and a signal to noise ratio of 20 dB is obtained. The second improved version is able to detect the four multiplexed FBGs placed 250 km away, offering a signal to noise ratio of 6–8 dB. Consequently, this last system represents the longest range FBG sensor system reported so far that includes fiber sensor multiplexing capability. Both simple systems are based on a wavelength swept laser to scan the reflection spectra of the FBGs, and they are composed by two identical-lengths optical paths: the first one intended to launch the amplified laser signal by means of Raman amplification and the other one is employed to guide the reflection signal to the reception system. PMID:22164101

  12. Cascade sensitivity studies for KM3NeT

    NASA Astrophysics Data System (ADS)

    Fusco, L. A.; KM3NeT Collaboration

    2016-01-01

    KM3NeT is a future neutrino observatory to be built in the Mediterranean Sea. Its main astrophysical goal it to search for cosmic sources of neutrinos. The status of searches for diffuse fluxes of cosmic neutrinos in the cascade channel are reported in this contribution. A signal analogous to that observed by the IceCube collaboration will be observed with a 5 σ significance within one year of operation of the detector.

  13. The KM3NeT neutrino telescope

    NASA Astrophysics Data System (ADS)

    Coniglione, R.; KM3NeT Collaboration

    2015-08-01

    The construction phase of an underwater high energy neutrino telescope in the Mediterranean Sea, named KM3NeT, has started. The neutrino telescope that will consist of several blocks of instrumented structures will have a size of the order of a cubic-kilometer. In this work the main elements of the detector, the status of the project and the expected performance will be briefly reported.

  14. Towards a 1km resolution global flood risk model

    NASA Astrophysics Data System (ADS)

    Bates, Paul; Neal, Jeff; Sampson, Chris; Smith, Andy

    2014-05-01

    Recent advances in computationally efficient numerical algorithms and new High Performance Computing architectures now make high (1-2km) resolution global hydrodynamic models a realistic proposition. However in many areas of the world the data sets and tools necessary to undertake such modelling do not currently exist. In particular, five major problems need to be resolved: (1) the best globally available terrain data (SRTM) was generated from X-band interferometric radar data which does not penetrate vegetation canopies and which has significant problems in determining ground elevations in urban areas; (2) a global river bathymetry data set does not currently exist; (3) most river channels globally are less than the smallest currently resolvable grid scale (1km) and therefore require a sub-grid treatment; (4) a means to estimate the magnitude of the T year flood at any point along the global river network does not currently exist; and (5) a large proportion of flood losses are generated by off-floodplain surface water flows which are not well represented in current hydrodynamic modelling systems. In this paper we propose solutions to each of these five issues as part of a concerted effort to develop a 1km (or better) resolution global flood hazard model. We describe the new numerical algorithms, computer architectures and computational resources used, and demonstrate solutions to the five previously intractable problems identified above. We conduct a validation study of the modelling against satellite imagery of major flooding on the Mississippi-Missouri confluence plain in the central USA before outlining a proof-of-concept regional study for SE Asia as a step towards a global scale model. For SE Asia we simulate flood hazard for ten different flood return periods over the entire Thailand, Cambodia, Vietnam, Malaysia and Laos region at 1km resolution and show that the modelling produces coherent, consistent and sensible simulations of extent and water depth.

  15. Organizations, Paradigms, and People: The Challenge of KM Interventions

    NASA Technical Reports Server (NTRS)

    Bailey, Teresa; Burton, Yvette

    1999-01-01

    This paper presents viewgraphs on Knowledge Management (KM) and how these interventions are put into practice by organizations and society. The topics include: 1) The Multiple Paradigm Tool; 2) Four Paradigms: tool for the Analyzing Organizations; 3) Assumptions About the Nature of Social Science; 4) Assumptions About the Nature of Society; 5) Schools of Sociological and Organizational Theory; 6) Meaning and Metaphors in the Four Paradigms; and 7) Possibilities and Conclusions.

  16. Hypervelocity launch capabilities to over 10 km/s

    SciTech Connect

    Chhabildas, L.C.

    1991-01-01

    Very high pressure and acceleration is necessary to launch flier plates to hypervelocities. In addition, the high pressure loading must be uniform, structured, and shockless, i.e., time-dependent to prevent the flier plate from either fracturing or melting. In this paper, a novel technique is described which allows the use of megabar level loading pressures, and 10{sup 9} g acceleration to launch intact flier plates to velocities of 12.2 km/s. 32 refs., 2 figs.

  17. Saqqar: A 34 km diameter impact structure in Saudi Arabia

    NASA Astrophysics Data System (ADS)

    Kenkmann, Thomas; Afifi, Abdulkader M.; Stewart, Simon A.; Poelchau, Michael H.; Cook, Douglas J.; Neville, Allen S.

    2015-11-01

    Here we present the first proof of an impact origin for the Saqqar circular structure in northwestern Saudi Arabia (Neville et al. ), with an apparent diameter of 34 km, centered at 29°35'N, 38°42'E. The structure is formed in Cambrian-Devonian siliciclastics and is unconformably overlain by undeformed Cretaceous and Paleogene sediments. The age of impact is not well constrained and lies somewhere between 410 and 70 Ma. The subsurface structure is constrained by 2-D reflection seismic profiles and six drilled wells. First-order structural features are a central uplift that rises approximately 2 km above regional datums, surrounded by a ring syncline. The crater rim is defined by circumferential normal faults. The central uplift and ring syncline correspond to a Bouguer gravity high and an annular ring-like low, respectively. The wells were drilled within the central uplift, the deepest among them exceed 2 km depth. Sandstone core samples from these wells show abundant indicators of a shock metamorphic overprint. Planar deformation features (PDFs) were measured with orientations along (0001), {101¯3}, and less frequently along {101¯1} and {101¯4}. Planar fractures (PFs) predominantly occur along (0001) and {101¯1}, and are locally associated with feather features (FFs). In addition, some shocked feldspar grains and strongly deformed mica flakes were found. The recorded shock pressure ranges between 5 and 15 GPa. The preserved level of shock and the absence of an allochthonous crater fill suggest that Saqqar was eroded by 1-2 km between the Devonian and Maastrichtian. The documentation of unequivocal shock features proves the formation of the Saqqar structure by a hypervelocity impact event.

  18. Acceleration of barium ions near 8000 km above an aurora

    NASA Technical Reports Server (NTRS)

    Stenbaek-Nielsen, H. C.; Hallinan, T. J.; Wescott, E. M.; Foeppl, H.

    1984-01-01

    A barium shaped charge, named Limerick, was released from a rocket launched from Poker Flat Research Range, Alaska, on March 30, 1982, at 1033 UT. The release took place in a small auroral breakup. The jet of ionized barium reached an altitude of 8100 km 14.5 min after release, indicating that there were no parallel electric fields below this altitude. At 8100 km the jet appeared to stop. Analysis shows that the barium at this altitude was effectively removed from the tip. It is concluded that the barium was actually accelerated upward, resulting in a large decrease in the line-of-sight density and hence the optical intensity. The parallel electric potential in the acceleration region must have been greater than 1 kV over an altitude interval of less than 200 km. The acceleration region, although presumably auroral in origin, did not seem to be related to individual auroral structures, but appeared to be a large-scale horizontal structure. The perpendicular electric field below, as deduced from the drift of the barium, was temporally and spatially very uniform and showed no variation related to individual auroral structures passing through.

  19. Demonstration of Femtosecond-Phase Stabilization in 2 km OpticalFiber

    SciTech Connect

    Staples, J.W.; Wilcox, R.; Byrd, J.M.

    2007-06-01

    Long-term phase drifts of less than a femtosecond per hour have been demonstrated in a 2 km length of single-mode optical fiber, stabilized interferometrically at 1530 nm. Recent improvements include a wide-band phase detector that reduces the possibility of fringe jumping due to fast external perturbations of the fiber and locking of the master CW laser wavelength to an atomic absorption line. Mode-locked lasers may be synchronized using two wavelengths of the comb, multiplexed over one fiber, each wavelength individually interferometrically stabilized.

  20. Case of allergic contact dermatitis due to 1,3-butylene glycol.

    PubMed

    Aizawa, Atsuko; Ito, Akiko; Masui, Yukiko; Ito, Masaaki

    2014-09-01

    1,3-Butylene glycol (1,3-BG) is widely used in cosmetics, including low-irritant skin care products and topical medicaments, as an excellent and low-irritation humectant. We report a case of allergic contact dermatitis caused by 1,3-BG. A 28-year-old woman suffered from an itchy erythematous eruption on her face. By 2 days of closed patch testing, her own cosmetics and many of the hypo-irritant skin care products showed positive results. A second patch testing showed positive reaction to 1,3-BG (1% and 5%). 1,3-BG was a common component in most of the products that had elicited a positive reaction in the first patch testing. Although allergic contact dermatitis due to 1,3-BG is not so common, we have to consider 1,3-BG as a possible contact allergen in the patients presenting with allergic contact dermatitis due to various cosmetics.

  1. Efficient production and secretion of pyruvate from Halomonas sp. KM-1 under aerobic conditions.

    PubMed

    Kawata, Yoshikazu; Nishimura, Taku; Matsushita, Isao; Tsubota, Jun

    2016-03-01

    The alkaliphilic, halophilic bacterium Halomonas sp. KM-1 can utilize both hexose and pentose sugars for the intracellular storage of bioplastic poly-(R)-3-hydroxybutyric acid (PHB) under aerobic conditions. In this study, we investigated the effects of the sodium nitrate concentration on PHB accumulation in the KM-1 strain. Unexpectedly, we observed the secretion of pyruvate, a central intermediate in carbon- and energy-metabolism processes in all organisms; therefore, pyruvate is widely used as a starting material in the industrial biosynthesis of pharmaceuticals and is employed for the production of crop-protection agents, polymers, cosmetics, and food additives. We then further analyzed pyruvate productivity following changes in culture temperature and the buffer concentration. In 48-h batch-cultivation experiments, we found that wild-type Halomonas sp. KM-1 secreted 63.3 g/L pyruvate at a rate of 1.32 g/(L·h), comparable to the results of former studies using mutant and recombinant microorganisms. Thus, these data provided important insights into the production of pyruvate using this novel strain.

  2. PEDOT modified LiNi1/3Co1/3Mn1/3O2 with enhanced electrochemical performance for lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Liu, Xizheng; Li, Huiqiao; Li, De; Ishida, Masayoshi; Zhou, Haoshen

    2013-12-01

    Layered LiNi1/3Co1/3Mn1/3O2 was modified by poly(3,4-dioxyethylenethiophene) PEDOT via a facile method and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and infrared spectroscopy (IR). PEDOT modified samples exhibited both improved rate and cycle performance compared with the pristine LiNi1/3Co1/3Mn1/3O2. At a charge/discharge current of 1500 mA g-1, the discharge capacity was improved from 44.3 to 73.9 mAh g-1. The sample with 2 wt% and heat treated at 300 °C showed the optimized electrochemical performance. Galvanostatic intermittent titration technique (GITT) and cyclic voltammetry (CV) results indicated that the battery polarization of coated samples have been suppressed obviously because the PEDOT layer facilitated the electron transfer at the interface of electrode and electrolyte.

  3. Calendering effects on the physical and electrochemical properties of Li[Ni1/3Mn1/3Co1/3]O2 cathode

    NASA Astrophysics Data System (ADS)

    Zheng, Honghe; Tan, Li; Liu, Gao; Song, Xiangyun; Battaglia, Vincent S.

    2012-06-01

    Li[Ni1/3Mn1/3Co1/3]O2 cathode laminate containing 8% PVDF and 7% acetylene black is fabricated and calendered to different porosities. Calendering effects on the physical and electrochemical properties of the Li[Ni1/3Mn1/3Co1/3]O2 cathode are investigated. It is found that mechanical properties of the composite laminate strongly depend on the electrode porosity whereas the electronic conductivity is not significantly affected by calendering. Electrochemical performances including the specific capacity, the first coulombic efficiency, cycling performance and rate capability for the cathode at different porosities are compared. An optimized porosity of around 30-40% is identified. Electrochemical impedance spectroscopy (EIS) studies illustrate that calendering improves the electronic conductivity between active particles at relatively high porosities, but increases charge transfer resistance at electrode/electrolyte interface at relatively low porosities. An increase of activation energy of Li interfacial transfer for the electrode at 0% porosity indicates a relatively high barrier of activation at the electrode/electrolyte interface, which accounts for the poor rate capability of the electrode at extremely low porosity.

  4. Capacity improvement by deficit of transition metals in inverse spinel LiNi1/3Co1/3Mn1/3VO4 cathodes

    NASA Astrophysics Data System (ADS)

    Kitajou, Ayuko; Yoshida, Jun; Nakanishi, Shinji; Matsuda, Yasuaki; Kanno, Ryoji; Okajima, Toshihiro; Okada, Shigeto

    2016-01-01

    Although inverse spinel materials have attracted attention because of their unusually high voltage characteristics, their rechargeable capacities are generally less than 50 mAh g-1, as a result of the coexistence of Li and transition metal ions at 16d octahedral sites. This work attempted to improve cathode functioning by optimizing the quantities of Li and transition metal ions residing at the 16d sites of LiNi1/3Co1/3Mn1/3VO4. The rechargeable capacity of the LiNi0.28Co0.28Mn0.26V0.80O4 synthesized in the present study was found to be above 120 mAh g-1, representing the largest capacity reported to date for an inverse spinel material. The results of in-situ XANES analysis demonstrated that the charge-discharge reactions of LiNi1/3Co1/3Mn1/3VO4 corresponds to the Mn2+/Mn4+ and Co2+/Co3+ redox couples, mainly.

  5. Nuclear localization and functional characteristics of voltage-gated potassium channel Kv1.3.

    PubMed

    Jang, Soo Hwa; Byun, Jun Kyu; Jeon, Won-Il; Choi, Seon Young; Park, Jin; Lee, Bo Hyung; Yang, Ji Eun; Park, Jin Bong; O'Grady, Scott M; Kim, Dae-Yong; Ryu, Pan Dong; Joo, Sang-Woo; Lee, So Yeong

    2015-05-15

    It is widely known that ion channels are expressed in the plasma membrane. However, a few studies have suggested that several ion channels including voltage-gated K(+) (Kv) channels also exist in intracellular organelles where they are involved in the biochemical events associated with cell signaling. In the present study, Western blot analysis using fractionated protein clearly indicates that Kv1.3 channels are expressed in the nuclei of MCF7, A549, and SNU-484 cancer cells and human brain tissues. In addition, Kv1.3 is located in the plasma membrane and the nucleus of Jurkat T cells. Nuclear membrane hyperpolarization after treatment with margatoxin (MgTX), a specific blocker of Kv1.3 channels, provides evidence for functional channels at the nuclear membrane of A549 cells. MgTX-induced hyperpolarization is abolished in the nuclei of Kv1.3 silenced cells, and the effects of MgTX are dependent on the magnitude of the K(+) gradient across the nuclear membrane. Selective Kv1.3 blockers induce the phosphorylation of cAMP response element-binding protein (CREB) and c-Fos activation. Moreover, Kv1.3 is shown to form a complex with the upstream binding factor 1 in the nucleus. Chromatin immunoprecipitation assay reveals that Sp1 transcription factor is directly bound to the promoter region of the Kv1.3 gene, and the Sp1 regulates Kv1.3 expression in the nucleus of A549 cells. These results demonstrate that Kv1.3 channels are primarily localized in the nucleus of several types of cancer cells and human brain tissues where they are capable of regulating nuclear membrane potential and activation of transcription factors, such as phosphorylated CREB and c-Fos.

  6. Nuclear Localization and Functional Characteristics of Voltage-gated Potassium Channel Kv1.3*

    PubMed Central

    Jang, Soo Hwa; Byun, Jun Kyu; Jeon, Won-Il; Choi, Seon Young; Park, Jin; Lee, Bo Hyung; Yang, Ji Eun; Park, Jin Bong; O'Grady, Scott M.; Kim, Dae-Yong; Ryu, Pan Dong; Joo, Sang-Woo; Lee, So Yeong

    2015-01-01

    It is widely known that ion channels are expressed in the plasma membrane. However, a few studies have suggested that several ion channels including voltage-gated K+ (Kv) channels also exist in intracellular organelles where they are involved in the biochemical events associated with cell signaling. In the present study, Western blot analysis using fractionated protein clearly indicates that Kv1.3 channels are expressed in the nuclei of MCF7, A549, and SNU-484 cancer cells and human brain tissues. In addition, Kv1.3 is located in the plasma membrane and the nucleus of Jurkat T cells. Nuclear membrane hyperpolarization after treatment with margatoxin (MgTX), a specific blocker of Kv1.3 channels, provides evidence for functional channels at the nuclear membrane of A549 cells. MgTX-induced hyperpolarization is abolished in the nuclei of Kv1.3 silenced cells, and the effects of MgTX are dependent on the magnitude of the K+ gradient across the nuclear membrane. Selective Kv1.3 blockers induce the phosphorylation of cAMP response element-binding protein (CREB) and c-Fos activation. Moreover, Kv1.3 is shown to form a complex with the upstream binding factor 1 in the nucleus. Chromatin immunoprecipitation assay reveals that Sp1 transcription factor is directly bound to the promoter region of the Kv1.3 gene, and the Sp1 regulates Kv1.3 expression in the nucleus of A549 cells. These results demonstrate that Kv1.3 channels are primarily localized in the nucleus of several types of cancer cells and human brain tissues where they are capable of regulating nuclear membrane potential and activation of transcription factors, such as phosphorylated CREB and c-Fos. PMID:25829491

  7. Emission of 1,3-butadiene from petrol-driven motor vehicles

    NASA Astrophysics Data System (ADS)

    Ye, Y.; Galbally, I. E.; Weeks, I. A.

    This study reports the measurement of 1,3-butadiene emissions from 30 petrol-driven vehicles from the Australian car fleet using the Australian Design Rule 37/00 vehicle test procedure. Six of the cars tested were not equipped with catalytic converters and used leaded petrol as fuel. The remaining 24 cars were fitted with catalytic converters and used unleaded petrol. 1,3-Butadiene in exhaust samples was found to degrade rapidly in SUMMA treated stainless steel canisters and the degradation followed first-order kinetics. The rate coefficient of the decay can be represented by a linear dependence on the concentration of nitrogen oxides in the exhaust ( r2 = 0.79, n = 43), and the gas-phase reaction of NO 2 and 1,3-butadiene may have a major role in this loss. The 1,3-butadiene concentrations used to estimate vehicle emissions were corrected for this loss using the decay rate constant either observed from replicate analyses or from the NO x concentrations in the samples. The measurements showed that 1,3-butadiene was emitted at a rate of 20.7 ± 9.2 mg km -1 from 6 non-catalyst vehicles. There was considerable scatter in the observations from catalyst equipped vehicles and we infer that this was due to the malfunction of the emission control devices on some vehicles. The 19 vehicles that appeared to have functioning catalyst emission control devices had an average emission rate of 2.1 ± 1.5 mg km -1. These emission rates are consistent with atmospheric observations and are much higher than those reported previously. We calculate that more than 90% of the 1,3-butadiene in engine exhaust comes from the common alkane and aromatic constituents of the fuel. A comparison of emissions in the different phases of the drive cycle indicates that current emission controls remove more than 90% of the 1,3-butadiene from the initial exhaust mixture.

  8. Analysis of sex differences in open-water ultra-distance swimming performances in the FINA World Cup races in 5 km, 10 km and 25 km from 2000 to 2012

    PubMed Central

    2014-01-01

    Background The present study investigated the changes in swimming speeds and sex differences for elite male and female swimmers competing in 5 km, 10 km and 25 km open-water FINA World Cup races held between 2000 and 2012. Methods The changes in swimming speeds and sex differences across years were analysed using linear, non-linear, and multi-level regression analyses for the annual fastest and the annual ten fastest competitors. Results For the annual fastest, swimming speed remained stable for men and women in 5 km (5.50 ± 0.21 and 5.08 ± 0.19 km/h, respectively), in 10 km (5.38 ± 0.21 and 5.05 ± 0.26 km/h, respectively) and in 25 km (5.03 ± 0.32 and 4.58 ± 0.27 km/h, respectively). In the annual ten fastest, swimming speed remained constant in 5 km in women (5.02 ± 0.19 km/h) but decreased significantly and linearly in men from 5.42 ± 0.03 km/h to 5.39 ± 0.02 km/h. In 10 km, swimming speed increased significantly and linearly in women from 4.75 ± 0.01 km/h to 5.74 ± 0.01 km/h but remained stable in men at 5.36 ± 0.21 km/h. In 25 km, swimming speed decreased significantly and linearly in women from 4.60 ± 0.06 km/h to 4.44 ± 0.08 km/h but remained unchanged at 4.93 ± 0.34 km/h in men. For the annual fastest, the sex difference in swimming speed remained unchanged in 5 km (7.6 ± 3.0%), 10 km (6.1 ± 2.5%) and 25 km (9.0 ± 3.7%). For the annual ten fastest, the sex difference remained stable in 5 km at 7.6 ± 0.6%, decreased significantly and linearly in 10 km from 7.7 ± 0.7% to 1.2 ± 0.3% and increased significantly and linearly from 4.7 ± 1.4% to 9.6 ± 1.5% in 25 km. Conclusions To summarize, elite female open-water ultra-distance swimmers improved in 10 km but impaired in 25 km leading to a linear decrease in sex difference in 10 km and a linear increase in sex difference in 25 km. The linear changes in sex differences

  9. Cell immobilization for microbial production of 1,3-propanediol.

    PubMed

    Gungormusler-Yilmaz, Mine; Cicek, Nazim; Levin, David B; Azbar, Nuri

    2016-01-01

    Cell and enzyme immobilization are often used for industrial production of high-value products. In recent years, immobilization techniques have been applied to the production of value-added chemicals such as 1,3-Propanediol (1,3-PDO). Biotechnological fermentation is an attractive alternative to current 1,3-PDO production methods, which are primarily thermochemical processes, as it generates high volumetric yields of 1,3-PDO, is a much less energy intensive process, and generates lower amounts of environmental organic pollutants. Although several approaches including: batch, fed-batch, continuous-feed and two-step continuous-feed were tested in suspended systems, it has been well demonstrated that cell immobilization techniques can significantly enhance 1,3-PDO production and allow robust continuous production in smaller bioreactors. This review covers various immobilization methods and their application for 1,3-PDO production.

  10. Mapping the global land surface using 1 km AVHRR data

    USGS Publications Warehouse

    Lauer, D.T.; Eidenshink, J.C.

    1998-01-01

    The scientific requirements for mapping the global land surface using 1 km advanced very high resolution radiometer (AVHRR) data have been set forth by the U.S. Global Change Research Program; the International Geosphere Biosphere Programme (IGBP); The United Nations; the National Oceanic and Atmospheric Administration (NOAA); the Committee on Earth Observations Satellites; and the National Aeronautics and Space Administration (NASA) mission to planet Earth (MTPE) program. Mapping the global land surface using 1 km AVHRR data is an international effort to acquire, archive, process, and distribute 1 km AVHRR data to meet the needs of the international science community. A network of AVHRR receiving stations, along with data recorded by NOAA, has been acquiring daily global land coverage since April 1, 1992. A data set of over 70,000 AVHRR images is archived and distributed by the United States Geological Survey (USGS) EROS Data Center, and the European Space Agency. Under the guidance of the IGBP, processing standards have been developed for calibration, atmospheric correction, geometric registration, and the production of global 10-day maximum normalized difference vegetation index (NDVI) composites. The major uses of the composites are for the study of surface vegetation condition, mapping land cover, and deriving biophysical characteristics of terrestrial ecosystems. A time-series of 54 10-day global vegetation index composites for the period of April 1, 1992 through September 1993 has been produced. The production of a time-series of 33 10-day global vegetation index composites using NOAA-14 data for the period of February 1, 1995 through December 31, 1995 is underway. The data products are available from the USGS, in cooperation with NASA's MTPE program and other international organizations.

  11. Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum.

    PubMed

    Tsai, Yi-Ying; Huang, Chiung-Yao; Tseng, Wan-Ru; Chiang, Pei-Lun; Hwang, Tsong-Long; Su, Jui-Hsin; Sung, Ping-Jyun; Dai, Chang-Feng; Sheu, Jyh-Horng

    2017-03-01

    New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2(-)) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too.

  12. Development of km23-Based Diagnostics and Therapeutics

    DTIC Science & Technology

    2005-05-01

    Attisano, L., Wieser, R., Ventura , F., and Massagu6, J. (1994) Nature 370, 341-347 28. Biggs, J. R., Kraft, A. S. (1999) J. Biol. Chem. 274, 36987-36994...Macias- Silva et al; 1996). Since blockade of km23 could reduce both the levels of phosphorylated Smad2 and the nuclear expression of Smad2, it was of...in TGF-P signaling. Front BioscL. 8, 1280-1303. Macias- Silva , M., Abdollah, S., Hoodless, P. A., Pirone, R., and Attisano, L., Wrana, J. L. (1996

  13. The relational database system of KM3NeT

    NASA Astrophysics Data System (ADS)

    Albert, Arnauld; Bozza, Cristiano

    2016-04-01

    The KM3NeT Collaboration is building a new generation of neutrino telescopes in the Mediterranean Sea. For these telescopes, a relational database is designed and implemented for several purposes, such as the centralised management of accounts, the storage of all documentation about components and the status of the detector and information about slow control and calibration data. It also contains information useful during the construction and the data acquisition phases. Highlights in the database schema, storage and management are discussed along with design choices that have impact on performances. In most cases, the database is not accessed directly by applications, but via a custom designed Web application server.

  14. An evaluation of the global 1-km AVHRR land dataset

    USGS Publications Warehouse

    Teillet, P.M.; El Saleous, N.; Hansen, M.C.; Eidenshink, Jeffery C.; Justice, C.O.; Townshend, J.R.G.

    2000-01-01

    This paper summarizes the steps taken in the generation of the global 1-km AVHRR land dataset, and it documents an evaluation of the data product with respect to the original specifications and its usefulness in research and applications to date. The evaluation addresses data characterization, processing, compositing and handling issues. Examples of the main scientific outputs are presented and options for improved processing are outlined and prioritized. The dataset has made a significant contribution, and a strong recommendation is made for its reprocessing and continuation to produce a long-term record for global change research.

  15. 157km BOTDA with pulse coding and image processing

    NASA Astrophysics Data System (ADS)

    Qian, Xianyang; Wang, Zinan; Wang, Song; Xue, Naitian; Sun, Wei; Zhang, Li; Zhang, Bin; Rao, Yunjiang

    2016-05-01

    A repeater-less Brillouin optical time-domain analyzer (BOTDA) with 157.68km sensing range is demonstrated, using the combination of random fiber laser Raman pumping and low-noise laser-diode-Raman pumping. With optical pulse coding (OPC) and Non Local Means (NLM) image processing, temperature sensing with +/-0.70°C uncertainty and 8m spatial resolution is experimentally demonstrated. The image processing approach has been proved to be compatible with OPC, and it further increases the figure-of-merit (FoM) of the system by 57%.

  16. Castro ring zone: a 4,500-km2 fossil hydrothermal system in the Challis volcanic field, central Idaho.

    USGS Publications Warehouse

    Criss, R.E.; Ekren, E.B.; Hardyman, R.F.

    1984-01-01

    The largest fossil hydrothermal system occupying a 4500 km2 area in central Idaho is revealed by delta 18O studies. The remains of this meteoric-hydrothermal system are preserved within a sharply bounded, 15 km wide, 70-km-diameter annulus of low delta 18O rock (+2.0 to -8.8per mille) termed the Castro ring zone. The zone is centred on a less depleted (+4.5) core zone consisting of granitic rocks of the Castro pluton. This 700-km2 Eocene subvolcanic batholith has intruded, domed, and hydrothermally metamorphosed a thick sequence of Challis Volcanics, the stratigraphically low rocks in the 2000-km2 Van Horn Peak and the 1000-km2 Thunder Mountain cauldron complexes being most strongly altered. Less extreme 18O depletions occur in the youngest major ash-flow sheets of these complexes, indicating a vertical 18O gradient. Water/rock ratios of geothermal systems are surprisingly insensitive to the circulation scale.-L.-di H.

  17. HEALTH ASSESSMENT OF 1,3-BUTADIENE | Science ...

    EPA Pesticide Factsheets

    This assessment was conducted to review the new information that has become available since EPA's 1985 health assessment of 1,3-butadiene.1,3-Butadiene is a gas used commercially in the production of styrene-butadiene rubber, plastics, and thermoplastic resins. The major environmental source of 1,3-butadiene is the incomplete combustion of fuels from mobile sources (e.g., automobile exhaust). Tobacco smoke can be a significant source of 1,3-butadiene in indoor air.This assessment concludes that 1,3-butadiene is carcinogenic to humans by inhalation, based on the total weight of evidence. The specific mechanisms of 1,3-butadiene-induced carcinogenesis are unknown; however, it is virtually certain that the carcinogenic effects are mediated by genotoxic metabolites of 1,3-butadiene.Animal data suggest that females may be more sensitive than males for cancer effects; nevertheless, there are insufficient data from which to draw any conclusions on potentially sensitive subpopulations.The human incremental lifetime unit cancer (incidence) risk estimate is based on extrapolation from leukemias observed in an occupational epidemiologic study. A twofold adjustment to the epidemiologic-based unit cancer risk is then applied to reflect evidence from the rodent bioassays suggesting that the epidemiologic-based estimate may underestimate total cancer risk from 1,3-butadiene exposure in the general population. 1,3-Butadiene also causes a variety of reproductive and develop

  18. KM3NeT/ORCA status and plans

    NASA Astrophysics Data System (ADS)

    Samtleben, Dorothea F. E.

    2016-04-01

    Neutrinos created in interactions of cosmic rays with the atmosphere can serve as a powerful tool to unveil the neutrino mass hierarchy (NMH). At low energies, around a few GeV, matter effects from the transition through the Earth are expected to imprint a distinct but also subtle signature on the oscillation pattern, specific to the ordering of the neutrino masses. KM3NeT/ORCA (Oscillations Research with Cosmics in the Abyss), a densely instrumented building block of the upcoming KM3NeT neutrino telescope, will be designated to measuring this signature in the Mediterranean Sea. Using detailed simulations the sensitivity towards this signature has been evaluated. The multi-PMT detectors allow in the water for an accurate reconstruction of GeV neutrino event signatures and distinction of neutrino flavours. For the determination of the mass hierarchy a median significance of 2-6σ has been estimated for three years of data taking, depending on the actual hierarchy and the oscillation parameters. At the same time the values of several oscillation parameters like θ23 will be determined to unprecedented precision.

  19. CO2 LIDAR measurements over a 20-km slant path

    NASA Astrophysics Data System (ADS)

    Senft, Daniel C.; Fox, Marsha J.; Gonglewski, John D.; Dowling, James A.; Highland, Ronald G.; Shilko, Michael L.

    1997-01-01

    The Air Force Phillips Laboratory conducted a series of measurements in February, May and August 1995 at the Air Force Maui Optical Station (AMOS) facility on Maui, Hawaii, to determine system requirements for an airborne long path CO(subscript 2) DIAL system. The lidar incorporates a cavity-matched mode-locked 3-J laser with the 60 cm diameter AMOS Beam Director Telescope. The one-way beam propagation path length was 21.3 km, originating at the AMOS facility on Haleakala at an altitude of 3.050 km ASL, and terminating at a target site near sea level. Both heterodyne and direct detection techniques are compared with respect to radiometric performance and signal statistics. Minimum detectable absorption levels for DIAL systems using both detection techniques and a variety of targets are estimated from long- range measurements with controlled absorbers. The signal correlation as a function of interpulse temporal separation was determined for long-range direct detection measurements. Radiometric models including system optical characteristics, beam propagation considerations, target reflectivity characteristics,a nd atmospheric effects have been developed and validated experimentally. A new receiver system is currently being fabricated and the laser transmitter is being upgraded for pulse-to-pulse wavelength agility, prior to incorporation into a C-135E airborne platform for future flight experiments.

  20. Sentiment of Search: KM and IT for User Expectations

    NASA Technical Reports Server (NTRS)

    Berndt, Sarah Ann; Meza, David

    2014-01-01

    User perceived value is the number one indicator of a successful implementation of KM and IT collaborations. The system known as "Search" requires more strategy and workflow that a mere data dump or ungoverned infrastructure can provide. Monitoring of user sentiment can be a driver for providing objective measures of success and justifying changes to the user interface. The dynamic nature of information technology makes traditional usability metrics difficult to identify, yet easy to argue against. There is little disagreement, however, on the criticality of adapting to user needs and expectations. The Systems Usability Scale (SUS), developed by John Brook in 1986 has become an industry standard for usability engineering. The first phase of a modified SUS, polls the sentiment of representative users of the JSC Search system. This information can be used to correlate user determined value with types of information sought and how the system is (or is not) meeting expectations. Sentiment analysis by way of the SUS assists an organization in identification and prioritization of the KM and IT variables impacting user perceived value. A secondary, user group focused analysis is the topic of additional work that demonstrates the impact of specific changes dictated by user sentiment.

  1. Quantum crytography over 14km of installed optical fiber

    SciTech Connect

    Hughes, R.J.; Luther, G.G.; Morgan, G.L.; Simmons, C.

    1995-09-01

    We have made the first demonstration that low error rate quantum cryptography over long distances (14km) of installed optical fiber in a real-world environment, subject to uncontrolled temperature and mechanical influences, representing an important new step towards incorporation of quantum cryptography into existing information security systems. We also point out that the high visibility single-photon interference in our experiment allows us to infer a test of the superposition principle of quantum mechanics: a photon reaching the detector has traveled over 14km of optical fiber in a wavepacket comprising a coherent superposition of two components that are spatially separated by about 2m. In principle, there are decoherence processes (or even possible modifications of quantum mechanics) that could cause the photon`s wavefunction to collapse into one component or the other during propagation, leading to a reduction in visibility. However, our results are consistent with no such loss of quantum coherence during the 67-{mu}s propagation time.

  2. Changes in running mechanics and spring-mass behaviour during a 5-km time trial.

    PubMed

    Girard, O; Millet, G P; Slawinski, J; Racinais, S; Micallef, J P

    2013-09-01

    Research into the biomechanical manifestation of fatigue during exhaustive runs is increasingly popular but additional understanding of the adaptation of the spring-mass behaviour during the course of strenuous, self-paced exercises continues to be a challenge in order to develop optimized training and injury prevention programs. This study investigated continuous changes in running mechanics and spring-mass behaviour during a 5-km run. 12 competitive triathletes performed a 5-km running time trial (mean performance: ̴17 min 30 s) on a 200 m indoor track. Vertical and anterior-posterior ground reaction forces were measured every 200 m by a 5-m long force platform system, and used to determine spring-mass model characteristics. After a fast start, running velocity progressively decreased (- 11.6%; P<0.001) in the middle part of the race before an end spurt in the final 400-600 m. Stride length (- 7.4%; P<0.001) and frequency (- 4.1%; P=0.001) decreased over the 25 laps, while contact time (+ 8.9%; P<0.001) and total stride duration (+ 4.1%; P<0.001) progressively lengthened. Peak vertical forces (- 2.0%; P<0.01) and leg compression (- 4.3%; P<0.05), but not centre of mass vertical displacement (+ 3.2%; P>0.05), decreased with time. As a result, vertical stiffness decreased (- 6.0%; P<0.001) during the run, whereas leg stiffness changes were not significant (+ 1.3%; P>0.05). Spring-mass behaviour progressively changes during a 5-km time trial towards deteriorated vertical stiffness, which alters impact and force production characteristics.

  3. Mitigating 1,3-dichloropropene, chloropicrin, and methyl iodide emissions from fumigated soil with reactive film.

    PubMed

    Xuan, Richeng; Yates, Scott R; Ashworth, Daniel J; Luo, Lifang

    2012-06-05

    Implicated as a stratospheric ozone-depleting compound, methyl bromide (MeBr) is being phased out despite being considered to be the most effective soil fumigant. Its alternatives, i.e., 1,3-dichloropropene (1,3-D, which includes cis and trans isomers), chloropicrin (CP), and methyl iodide (MeI), have been widely used. High emissions of MeI from fumigated soil likely put farm workers and other bystanders at risk of adverse health effects. In this study, two types of constructed reactive film were tested for their ability to mitigate emissions of 1,3-D, CP, and MeI using laboratory permeability cells. Before activation, these films act as a physical barrier to trap fumigants leaving soil. After activation of the reactive layer containing ammonium thiosulfate solution, the films also act as a sink for the fumigants. Over 97% of trans-1,3-D and 99% of the cis-1,3-D, CP and MeI were depleted when they passed into the reactive film. Half-lives (t(1/2)) of cis-, trans-1,3-D, CP and MeI under activated reactive film were 1.2, 1.4, 1.6, and 2.0 h respectively at 40 °C.

  4. 1,3-Propanediol production by new recombinant Escherichia coli containing genes from pathogenic bacteria.

    PubMed

    Przystałowska, Hanna; Zeyland, Joanna; Szymanowska-Powałowska, Daria; Szalata, Marlena; Słomski, Ryszard; Lipiński, Daniel

    2015-02-01

    1,3-Propanediol (1,3-PDO) is an organic compound, which is a valuable intermediate product, widely used as a monomer for synthesizing biodegradable polymers, increasing their strength; as well as an ingredient of textile, cosmetic and medical products. 1,3-PDO is mostly synthesized chemically. Global companies have developed technologies for 1,3-PDO synthesis from petroleum products such as acrolein and ethylene oxide. A potentially viable alternative is offered by biotechnological processes using microorganisms capable of synthesizing 1,3-PDO from renewable substrates (waste glycerol, a by-product of biofuel production, or glucose). In the present study, genes from Citrobacter freundii and Klebsiella pneumoniae were introduced into Escherichia coli bacteria to enable the synthesis of 1,3-PDO from waste glycerol. These strains belong to the best 1,3-PDO producers, but they are pathogenic, which restricts their application in industrial processes. The present study involved the construction of two gene expression constructs, containing a total of six heterologous glycerol catabolism pathway genes from C. freundii ATCC 8090 and K. pneumoniae ATCC 700721. Heterologous genes encoding glycerol dehydratase (dhaBCE) and the glycerol dehydratase reactivation factor (dhaF, dhaG) from C. freundii and gene encoding 1,3-PDO oxidoreductase (dhaT) from K. pneumoniae were expressed in E. coli under the control of the T7lac promoter. An RT-PCR analysis and overexpression confirmed that 1,3-PDO synthesis pathway genes were expressed on the RNA and protein levels. In batch fermentation, recombinant E. coli bacteria used 32.6gl(-1) of glycerol to produce 10.6 gl(-1) of 1,3-PDO, attaining the efficiency of 0.4 (mol₁,₃-PDO molglycerol(-1)). The recombinant E. coli created is capable of metabolizing glycerol to produce 1,3-PDO, and the efficiency achieved provides a significant research potential of the bacterium. In the face of shortage of fossil fuel supplies and climate warming

  5. Lithium Diffusion & Magnetism in Battery Cathode Material LixNi1/3Co1/3Mn1/3O2

    NASA Astrophysics Data System (ADS)

    Månsson, M.; Nozaki, H.; Wikberg, J. M.; Prša, K.; Sassa, Y.; Dahbi, M.; Kamazawa, K.; Sedlak, K.; Watanabe, I.; Sugiyama, J.

    2014-12-01

    We have studied low-temperature magnetic properties as well as high-temperature lithium ion diffusion in the battery cathode materials LixNi1/3Co1/3Mn1/3O2 by the use of muon spin rotation/relaxation. Our data reveal that the samples enter into a 2D spin-glass state below TSG ≈ 12 K. We further show that lithium diffusion channels become active for T >= Tdiff ~ 125 K where the Li-ion hopping-rate [v(T)] starts to increase exponentially. Further, v(T) is found to fit very well to an Arrhenius type equation and the activation energy for the diffusion process is extracted as Ea ≈ 100 meV.

  6. 43 CFR 3420.1-3 - Special leasing opportunities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Special leasing opportunities. 3420.1-3... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COMPETITIVE LEASING Competitive Leasing § 3420.1-3 Special leasing opportunities. (a) The Secretary shall, under the procedures established...

  7. 43 CFR 3420.1-3 - Special leasing opportunities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Special leasing opportunities. 3420.1-3... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COMPETITIVE LEASING Competitive Leasing § 3420.1-3 Special leasing opportunities. (a) The Secretary shall, under the procedures established...

  8. 43 CFR 3420.1-3 - Special leasing opportunities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Special leasing opportunities. 3420.1-3... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COMPETITIVE LEASING Competitive Leasing § 3420.1-3 Special leasing opportunities. (a) The Secretary shall, under the procedures established...

  9. 48 CFR 970.0407-1-3 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 970.0407-1-3 Section 970.0407-1-3 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY... clause. The contracting officer shall insert the clause at 970.5204-3, Access to and Ownership of...

  10. 43 CFR 3140.1-3 - Exploration plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Exploration plans. 3140.1-3 Section 3140.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Conversion...

  11. 43 CFR 3140.1-3 - Exploration plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Exploration plans. 3140.1-3 Section 3140.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Conversion...

  12. 43 CFR 3140.1-3 - Exploration plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Exploration plans. 3140.1-3 Section 3140.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Conversion...

  13. 43 CFR 3140.1-3 - Exploration plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Exploration plans. 3140.1-3 Section 3140.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Conversion...

  14. 43 CFR 9185.1-3 - Mining claims.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Mining claims. 9185.1-3 Section 9185.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Mining claims. (a) Application for survey. Application for the survey of a mining claim should be...

  15. 43 CFR 9185.1-3 - Mining claims.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Mining claims. 9185.1-3 Section 9185.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Mining claims. (a) Application for survey. Application for the survey of a mining claim should be...

  16. 43 CFR 9185.1-3 - Mining claims.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Mining claims. 9185.1-3 Section 9185.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Mining claims. (a) Application for survey. Application for the survey of a mining claim should be...

  17. 43 CFR 9185.1-3 - Mining claims.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Mining claims. 9185.1-3 Section 9185.1-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... Mining claims. (a) Application for survey. Application for the survey of a mining claim should be...

  18. 43 CFR 3420.1-3 - Special leasing opportunities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Special leasing opportunities. 3420.1-3... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COMPETITIVE LEASING Competitive Leasing § 3420.1-3 Special leasing opportunities. (a) The Secretary shall, under the procedures established...

  19. The Effect of Water on the 410-km Discontinuity

    NASA Astrophysics Data System (ADS)

    Smyth, J. R.; Frost, D. J.

    2001-12-01

    The H content of the Earth is one of the most poorly constrained compositional variables for the planet. The nominally anhydrous olivine and spinelloid phases thought to compose the bulk of the upper mantle and transition zone may contain many times the amount of H and O that reside in the hydrosphere. The discontinuity at 410 kilometers corresponds to the olivine-wadsleyite transition with an increase in both density and S-wave velocity of about five percent. Previous experiments and calculations in the anhydrous peridotite system indicate an olivine-wadsleyite two-phase interval that is from 10 to 18 km in width. Calculations indicate that the two-phase region would be significantly broader in a hydrous system. We have conducted a series of synthesis experiments in the multi-anvil press on hydrous and anhydrous peridotite compositions and characterized the products by electron microprobe and single-crystal X-ray diffraction. Six experiments were conducted in a hydrous peridotite system, and three in an anhydrous system. The results of our synthesis experiments are consistent with the prediction of Wood (1995) that the presence of H2O extends the stability of wadsleyite to 0.6 to 1.0 GPa lower pressure and would broaden the two-phase loop to as much as 30 km. In the hydrous runs containing both olivine and wadsleyite, there appears a sharp boundary between regions of olivine and regions of wadsleyite. The texture of the run thus does not appear to be a simple chemical equilibrium, but rather a diffusion-controlled boundary. Hydrogen is known to diffuse very rapidly in these materials, raising the possibility that diffusion of H might control the texture and may affect the sharpness of the boundary in the natural system. Hydrous wadsleyite is about five percent denser than anhydrous olivine. In a hypothetical two-phase region consisting of olivine and wadsleyite plus lesser amounts of garnet and clinopyroxene extending over a depth 20 km in a hydrous system

  20. Sorption of the fumigant 1,3-dichloropropene on soil.

    PubMed

    Park, Moon-Ki; Kim, Jung-Ho; Dungan, Robert S

    2004-05-01

    The fumigant 1,3-dichloropropene (1,3-D) is considered a major replacement to methyl bromide, which is to be phased out of use in the United States by 2005. The main purpose of this study was to evaluate soil-water partitioning of 1,3-D in two California agricultural soils (Salinas clay loam and Arlington sandy loam). The partition coefficients (Kd and Kf) were determined by directly measuring the concentration of 1,3-D in the solid phase (Cs) and aqueous phase (Cw) after batch equilibration. In the Salinas clay loam, the Kf of cis-1,3-D in adsorption and desorption isotherms was 0.47 and 0.54, respectively, with respective values of 0.39 and 0.49 for trans-1,3-D. This slight hysteric effect suggests that a different range of forces are involved in the adsorption and desorption process. Since n was near unity in the Freundlich equation, the Freundlich isotherms can also be approximated using the liner isotherm. At 25 degrees C, the Kd of the 1,3-D isomers in both soils ranged from 0.46 to 0.56, and the Koc (organic matter partition coefficient) ranged from 58 to 70. The relatively low Kd values and a Koc that falls within the range of 50-150, suggests that 1,3-D is weakly sorbed and highly mobile in these soils. Understanding the sorption behavior of 1,3-D in soil is important when developing fumigation practices to reduce the movement of 1,3-D to the air and groundwater.

  1. The ion population between 1300 km and 230000 km in the coma of comet P/Halley

    NASA Technical Reports Server (NTRS)

    Altwegg, K.; Balsiger, H.; Geiss, J.; Goldstein, R.; Ip, W. -H.; Meier, A.; Neugebauer, M.; Rosenbauer, H.; Shelley, E.

    1993-01-01

    During the encounter of the spacecraft Giotto with Comet Halley the two sensors of the ion mass spectrometer (IMS), high energy range spectrometer (HERS) and high intensity spectrometer (HIS), measured the mass and the three-dimensional velocity distributions of cometary ions. HIS looked mainly at the cold, slow part of the distribution close to the nucleus, HERS at the more energetic pick-up ions further out. After a thorough recalibration of the HIS flight spare unit and an extensive data analysis we present here continuous ion density-, composition-, velocity-, and temperature profiles for the water group ion (mass range 16-19 amu/e) along Giotto's inbound trajectory from 230,000 to 1300 km from the comet nucleus. The two sensors are in very good agreement in the region where their measurements overlap thus giving an excellent data base for the discussion of theoretical comet models. The most prominent feature where models and observations disagree is the so called pile up region between 8000 and 15,000 km from the nucleus.

  2. Theoretical study of the thermodynamic properties, phase transition wave, and phase transition velocity for octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine

    SciTech Connect

    Long, Yao; Chen, Jun

    2015-09-21

    We develop a phonon-electron free energy model to study the thermodynamic properties and phase transitions of δ-octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine. The bulk modulus, thermal expansion coefficient, specific heat, Hugoniot curve, and phase transition curve are calculated in wide temperature and pressure ranges. The results are in agreement with the available experiments at zero pressure, and are reasonable predictions at high pressure for the lack of experiment. Two kinds of phase transition waves are investigated. We find the velocity of shock-induced phase transition wave is between 3400 m/s and 4700 m/s, and the velocity of self-sustaining phase transition wave is between 1300 m/s and 1900 m/s.

  3. Theoretical study of the thermodynamic properties, phase transition wave, and phase transition velocity for octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine

    NASA Astrophysics Data System (ADS)

    Long, Yao; Chen, Jun

    2015-09-01

    We develop a phonon-electron free energy model to study the thermodynamic properties and phase transitions of δ-octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine. The bulk modulus, thermal expansion coefficient, specific heat, Hugoniot curve, and phase transition curve are calculated in wide temperature and pressure ranges. The results are in agreement with the available experiments at zero pressure, and are reasonable predictions at high pressure for the lack of experiment. Two kinds of phase transition waves are investigated. We find the velocity of shock-induced phase transition wave is between 3400 m/s and 4700 m/s, and the velocity of self-sustaining phase transition wave is between 1300 m/s and 1900 m/s.

  4. Transport System for Delivery Tourists At Altitude 140 km

    NASA Technical Reports Server (NTRS)

    Bolonkin, Alexander

    2002-01-01

    The author offers a new method and installation for flight in space. This method uses the centrifugal force of a rotating circular cable that provides a means for the launch of a payload into outer space, to keep the fixed space stations at high altitudes (up to 200 km). The method may also be useful for landing to space bodies, for launching of the space ships (crafts), and for moving and accelerating other artificial apparatuses. The offered installation may be used as a propulsion system for space ships and/or probes. This system uses the material of any space body (i.e. stones) for acceleration and change of the space vehicle trajectory. The suggested system may be also used as a high capacity energy accumulator.

  5. Calibration methods and tools for KM3NeT

    NASA Astrophysics Data System (ADS)

    Kulikovskiy, Vladimir

    2016-04-01

    The KM3NeT detectors, ARCA and ORCA, composed of several thousands digital optical modules, are in the process of their realization in the Mediterranean Sea. Each optical module contains 31 3-inch photomultipliers. Readout of the optical modules and other detector components is synchronized at the level of sub-nanoseconds. The position of the module is measured by acoustic piezo detectors inside the module and external acoustic emitters installed on the bottom of the sea. The orientation of the module is obtained with an internal attitude and heading reference system chip. Detector calibration, i.e. timing, positioning and sea-water properties, is overviewed in this talk and discussed in detail in this conference. Results of the procedure applied to the first detector unit ready for installation in the deep sea will be shown.

  6. Measurement-Device-Independent Quantum Key Distribution over 200 km

    NASA Astrophysics Data System (ADS)

    Tang, Yan-Lin; Yin, Hua-Lei; Chen, Si-Jing; Liu, Yang; Zhang, Wei-Jun; Jiang, Xiao; Zhang, Lu; Wang, Jian; You, Li-Xing; Guan, Jian-Yu; Yang, Dong-Xu; Wang, Zhen; Liang, Hao; Zhang, Zhen; Zhou, Nan; Ma, Xiongfeng; Chen, Teng-Yun; Zhang, Qiang; Pan, Jian-Wei

    2014-11-01

    Measurement-device-independent quantum key distribution (MDIQKD) protocol is immune to all attacks on detection and guarantees the information-theoretical security even with imperfect single-photon detectors. Recently, several proof-of-principle demonstrations of MDIQKD have been achieved. Those experiments, although novel, are implemented through limited distance with a key rate less than 0.1 bit /s . Here, by developing a 75 MHz clock rate fully automatic and highly stable system and superconducting nanowire single-photon detectors with detection efficiencies of more than 40%, we extend the secure transmission distance of MDIQKD to 200 km and achieve a secure key rate 3 orders of magnitude higher. These results pave the way towards a quantum network with measurement-device-independent security.

  7. Estimating worldwide solar radiation resources on a 40km grid

    SciTech Connect

    Maxwell, E.L.; George, R.L.; Brady, E.H.

    1996-11-01

    During 1995, the National Renewable Energy Laboratory (NREL), initiated the Data Grid Task under the auspices of DOE`s Resource Assessment Program. A data grid is a framework of uniformly spaced locations (grid points) for which data are available. Estimates of monthly averages of direct normal, diffuse horizontal, and global horizontal daily-total solar radiation energy (kWh/m{sup 2}) are being made for each point on a grid covering the US, Mexico, the Caribbean, and southern Canada. The grid points are separated by approximately 40 km. Using interpolation methods, the digital data grid can be used to estimate solar resources at any location. The most encouraging result to date has been the location of sources providing worldwide data for most of the input parameters required for modeling daily total solar radiation. This is a multiyear task expected to continue through the rest of this century.

  8. Fatal truck-bicycle accident involving dragging for 45 km.

    PubMed

    Klintschar, M; Darok, M; Roll, P

    2003-08-01

    Vehicle-bicycle accidents with subsequent dragging of the rider over long distances are extremely rare. The case reported here is that of a 16-year-old mentally retarded bike rider who was run over by a truck whose driver failed to notice the accident. The legs of the victim became trapped by the rear axle of the trailer and the body was dragged over 45 km before being discovered under the parked truck. The autopsy revealed that the boy had died from the initial impact and not from the dragging injuries which had caused extensive mutilation. The reports of the technical expert and the forensic pathologist led the prosecutor to drop the case against the truck driver for manslaughter.

  9. Wintertime density perturbations near 50 km in relation to latitude

    NASA Technical Reports Server (NTRS)

    Quiroz, R. S.

    1977-01-01

    Standard and reference atmospheres which depict the horizontal distribution of air density in the stratosphere and mesosphere are not realistic in that they do not provide information on the large departures from standard that may occur during a given month, nor on the time- and space-scales of atmospheric perturbations responsible for these departures. In the present paper, it is shown how this information can be obtained from a special analysis of satellite radiance measurements. Plots of the mean zonal radiance, obtained with the VTPR instrument, and the corresponding 50-km density show not only the expected strong poleward gradient of density, but also a strong density surge from late December to early January, affecting all latitudes.

  10. Planar cell polarity genes, Celsr1-3, in neural development.

    PubMed

    Feng, Jia; Han, Qi; Zhou, Libing

    2012-06-01

    flamingo is among the 'core' planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1-3, are widely expressed in the nervous system. Recent work has shown that Celsr1-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.

  11. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Public Comment Draft)

    EPA Science Inventory

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  12. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (External Review Draft)

    EPA Science Inventory

    The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis suppor...

  13. Identification of ovine ruminal microbes capable of biotransforming hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bioremediation is of great interest in the detoxification of soil contaminated with residues from explosives such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). Although there are numerous forms of in situ and ex situ bioremediation, ruminants would provide the option of an in situ bioreactor tha...

  14. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Interagency Science Consultation Draft)

    EPA Science Inventory

    On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

  15. SoilGrids1km — Global Soil Information Based on Automated Mapping

    PubMed Central

    Hengl, Tomislav; de Jesus, Jorge Mendes; MacMillan, Robert A.; Batjes, Niels H.; Heuvelink, Gerard B. M.; Ribeiro, Eloi; Samuel-Rosa, Alessandro; Kempen, Bas; Leenaars, Johan G. B.; Walsh, Markus G.; Gonzalez, Maria Ruiperez

    2014-01-01

    Background Soils are widely recognized as a non-renewable natural resource and as biophysical carbon sinks. As such, there is a growing requirement for global soil information. Although several global soil information systems already exist, these tend to suffer from inconsistencies and limited spatial detail. Methodology/Principal Findings We present SoilGrids1km — a global 3D soil information system at 1 km resolution — containing spatial predictions for a selection of soil properties (at six standard depths): soil organic carbon (g kg−1), soil pH, sand, silt and clay fractions (%), bulk density (kg m−3), cation-exchange capacity (cmol+/kg), coarse fragments (%), soil organic carbon stock (t ha−1), depth to bedrock (cm), World Reference Base soil groups, and USDA Soil Taxonomy suborders. Our predictions are based on global spatial prediction models which we fitted, per soil variable, using a compilation of major international soil profile databases (ca. 110,000 soil profiles), and a selection of ca. 75 global environmental covariates representing soil forming factors. Results of regression modeling indicate that the most useful covariates for modeling soils at the global scale are climatic and biomass indices (based on MODIS images), lithology, and taxonomic mapping units derived from conventional soil survey (Harmonized World Soil Database). Prediction accuracies assessed using 5–fold cross-validation were between 23–51%. Conclusions/Significance SoilGrids1km provide an initial set of examples of soil spatial data for input into global models at a resolution and consistency not previously available. Some of the main limitations of the current version of SoilGrids1km are: (1) weak relationships between soil properties/classes and explanatory variables due to scale mismatches, (2) difficulty to obtain covariates that capture soil forming factors, (3) low sampling density and spatial clustering of soil profile locations. However, as the Soil

  16. Regulation of aldosterone secretion by Cav1.3

    PubMed Central

    Xie, Catherine B.; Haris Shaikh, Lalarukh; Garg, Sumedha; Tanriver, Gizem; Teo, Ada E. D.; Zhou, Junhua; Maniero, Carmela; Zhao, Wanfeng; Kang, Soosung; Silverman, Richard B.; Azizan, Elena A. B.; Brown, Morris J.

    2016-01-01

    Aldosterone-producing adenomas (APAs) vary in phenotype and genotype. Zona glomerulosa (ZG)-like APAs frequently have mutations of an L-type calcium channel (LTCC) CaV1.3. Using a novel antagonist of CaV1.3, compound 8, we investigated the role of CaV1.3 on steroidogenesis in the human adrenocortical cell line, H295R, and in primary human adrenal cells. This investigational drug was compared with the common antihypertensive drug nifedipine, which has 4.5-fold selectivity for the vascular LTCC, CaV1.2, over CaV1.3. In H295R cells transfected with wild-type or mutant CaV1.3 channels, the latter produced more aldosterone than wild-type, which was ameliorated by 100 μM of compound 8. In primary adrenal and non-transfected H295R cells, compound 8 decreased aldosterone production similar to high concentration of nifedipine (100 μM). Selective CaV1.3 blockade may offer a novel way of treating primary hyperaldosteronism, which avoids the vascular side effects of CaV1.2-blockade, and provides targeted treatment for ZG-like APAs with mutations of CaV1.3. PMID:27098837

  17. Dielectric properties of multiatomic alcohols: 1,3-butanediol

    NASA Astrophysics Data System (ADS)

    Zhuravlev, V. I.

    2016-10-01

    The dielectric spectra of 1,3-butanediol in the temperature range of 298-423 K are analyzed using a variety of theoretical approaches. It is shown that the dielectric spectra of 1,3-butanediol are described by the Davidson-Cole equation. Conclusions as to possible mechanisms of dispersion are drawn using the Debye theory. The relaxation times of 1,3-butanediol, calculated in different ways, are compared. The dipole moments of clusters are calculated for the first time using the Dissado-Hill cluster model.

  18. Evaluation of the 7-km GEOS-5 Nature Run

    NASA Technical Reports Server (NTRS)

    Gelaro, Ronald; Putman, William M.; Pawson, Steven; Draper, Clara; Molod, Andrea; Norris, Peter M.; Ott, Lesley; Prive, Nikki; Reale, Oreste; Achuthavarier, Deepthi; Bosilovich, Michael; Buchard, Virginie; Chao, Winston; Coy, Lawrence; Cullather, Richard; da Silva, Arlindo; Darmenov, Anton; Koster, Randal; McCarty, Will; Schubert, Siegfried

    2015-01-01

    This report documents an evaluation by the Global Modeling and Assimilation Office (GMAO) of a two-year 7-km-resolution non-hydrostatic global mesoscale simulation produced with the Goddard Earth Observing System (GEOS-5) atmospheric general circulation model. The simulation was produced as a Nature Run for conducting observing system simulation experiments (OSSEs). Generation of the GEOS-5 Nature Run (G5NR) was motivated in part by the desire of the OSSE community for an improved high-resolution sequel to an existing Nature Run produced by the European Centre for Medium-Range Weather Forecasts (ECMWF), which has served the community for several years. The intended use of the G5NR in this context is for generating simulated observations to test proposed observing system designs regarding new instruments and their deployments. Because NASA's interest in OSSEs extends beyond traditional weather forecasting applications, the G5NR includes, in addition to standard meteorological components, a suite of aerosol types and several trace gas concentrations, with emissions downscaled to 10 km using ancillary information such as power plant location, population density and night-light information. The evaluation exercise described here involved more than twenty-five GMAO scientists investigating various aspects of the G5NR performance, including time mean temperature and wind fields, energy spectra, precipitation and the hydrological cycle, the representation of waves, tropical cyclones and midlatitude storms, land and ocean surface characteristics, the representation and forcing effects of clouds and radiation, dynamics of the stratosphere and mesosphere, and the representation of aerosols and trace gases. Comparisons are made with observational data sets when possible, as well as with reanalyses and other long model simulations. The evaluation is broad in scope, as it is meant to assess the overall realism of basic aspects of the G5NR deemed relevant to the conduct of OSSEs

  19. 45-km horizontal-path optical link experiment

    NASA Astrophysics Data System (ADS)

    Biswas, Abhijit; Ceniceros, Juan M.; Novak, Matthew J.; Jeganathan, Muthu; Portillo, Angel; Erickson, David M.; de Pew, Jon; Sanii, B.; Lesh, James R.

    1999-04-01

    Mountain-top to mountain-top optical link experiments have been initiated at JPL, in order to perform a systems level evaluation of optical communications. Progress made so far is reported. The NASA, JPL developed optical communications demonstrator (OCD) is used to transmit a laser signal from Strawberry Peak (SP), located in the San Bernadino mountains of California. This laser beam is received by a 0.6 m aperture telescope at JPL's Table Mountain Facility (TMF), located in Wrightwood, California. The optical link is bi-directional with the TMF telescope transmitting a continuous 4-wave (cw) 780 nm beacon and the OCD sending back an 840 nm, 100 - 500 Mbps pseudo noise (PN) modulated, laser beam. The optical link path is at an average altitude of 2 Km above sea level, covers a range of 46.8 Km and provides an atmospheric channel equivalent to approximately 4 air masses. Average received power measured at either end fall well within the uncertainties predicted by link analysis. The reduction in normalized intensity variance ((sigma) I2) for the 4- beam beacon, compared to each individual beam, at SP, was from approximately 0.68 to 0.22. With some allowance for intra-beam mis-alignment, this is consistent with incoherent averaging. The (sigma) I2 measured at TMF approximately 0.43 plus or minus 0.22 exceeded the expected aperture averaged value of less than 0.1, probably because of beam wander. The focused spot sizes of approximately 162 plus or minus 6 micrometer at the TMF Coude and approximately 64 plus or minus 3 micrometer on the OCD compare to the predicted size range of 52 - 172 micrometer and 57 - 93 micrometer, respectively. This is consistent with 4 - 5 arcsec of atmospheric 'seeing.' The preliminary evaluation of OCD's fine tracking indicates that the uncompensated tracking error is approximately 3.3 (mu) rad compared to approximately 1.7 (mu) rad observed in the laboratory. Fine tracking performance was intermittent, primarily due to beacon fades on the

  20. Waste form characteristics report, revision 1.3

    SciTech Connect

    Leider, H.R.; Stout, R.B.

    1998-07-01

    This Waste Form Characteristics Report (WFCR) update, Version 1.3, incorporates substantial additions and changes to following 10 sections of the WFCR: 2.1.3.1 Cladding Degradation; 2.1.3.2 UO2 Oxidation in Fuel; 2.1.3.5 Dissolution Release from UO{sub 2}; 2.2.1.5 Fracture /Fragmentation Studies of Glass; 2.2.2.2 Dissolution Radionuclide Release from Glass; 2.2.2.3 Soluble-Precipitated/Colloidal Species from Glass; 3.2.2 Spent-Fuel Oxidation Models; 3.4.2 Spent-Fuel Dissolution Models; 3.5.1 Glass Dissolution Experimental Parameters; and 3.5.2 Glass Dissolution Models.

  1. 1. 3/4 VIEW, LOOKING NE. Philadelphia & Reading Railroad, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 3/4 VIEW, LOOKING NE. - Philadelphia & Reading Railroad, Pedestrian Suspension Bridge, Foot of Sixth Street at Schuylkill River (formerly spanned Philadelphia & Reading main line at Reading Depot), Reading, Berks County, PA

  2. 1,3,4-oxadiazole: a biologically active scaffold.

    PubMed

    Khalilullah, H; Ahsan, M J; Hedaitullah, Md; Khan, S; Ahmed, B

    2012-07-01

    There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiallergic, antipsychotic, antimicrobial, antimycobecterial, antitumour, antiviral and antitubercular activities. 1,3,4-oxadiazoles constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations led to the development of new 1,3,4-oxadiazole derivatives. This review article describes the various biological activities associated with 1,3,4-oxadiazole ring system and is useful in guiding the researchers across the world working on this moiety and consequently have been instrumental in the advancement of 1,3,4-oxadiazole chemistry.

  3. Relaxing the coenzyme specificity of 1,3-propanediol oxidoreductase from Klebsiella pneumoniae by rational design.

    PubMed

    Ma, Chengwei; Zhang, Le; Dai, Jianying; Xiu, Zhilong

    2010-04-15

    1,3-Propanediol has wide applications for large volume markets, particularly in the polymer business. Microbial production of 1,3-propanediol has been considered as a competitor to the traditional petrochemical routes. However, the formation of 1,3-propanediol is limited by the amount of NADH supplied by the oxidative pathway of glycerol dismutation. Previous metabolic flux analysis revealed that relaxation of the coenzyme specificity of 1,3-propanediol oxidoreductase for both NADH and NADPH would increase the production of 1,3-propanediol as well as maintaining the NADH-NAD(+) circle. This work tried to accomplish such a relaxation by rational protein design. Overall binding free energy indicated that the electrostatic energy was the major force discriminating NADH from NADPH. Computational alanine-scanning mutagenesis of the active site residues illustrated that Asp41 was the key residue responsible for the coenzyme specificity. Compared with Asp41Ala, Asp41Gly could further weaken the repulsion between Asp41 and the phosphate group esterified to the 2'-hydroxyl group of the ribose at the adenine end of NADPH. Site-directed mutagenesis was conducted and the relaxation was successfully realized.

  4. CMMI(Registered) for Services, Version 1.3

    DTIC Science & Technology

    2010-11-01

    Norimatsu, Norimatsu Process Engineering Lab, Inc. Mary Lynn Penn, Lockheed Martin Corporation David (Mike) Phillips , Software Engineering Institute...CMMI ® for Services, Version 1.3 CMMI-SVC, V1.3 CMMI Product Team Improving processes for providing better services November 2010...TECHNICAL REPORT CMU/SEI-2010-TR-034 ESC-TR-2010-034 Software Engineering Process Management Program Unlimited distribution subject to the

  5. CMMI(Registered) for Development, Version 1.3

    DTIC Science & Technology

    2010-11-01

    Engineering Institute So Norimatsu, Norimatsu Process Engineering Lab, Inc. Mary Lynn Penn, Lockheed Martin Corporation David (Mike) Phillips , Software...CMMI ® for Development, Version 1.3 CMMI-DEV, V1.3 CMMI Product Team Improving processes for developing better products and services...November 2010 TECHNICAL REPORT CMU/SEI-2010-TR-033 ESC-TR-2010-033 Software Engineering Process Management Program Unlimited distribution

  6. Just how wide should 'wide reading' be?

    PubMed

    Lipscomb, Martin

    2015-10-01

    Educationalists introduce students to literature search strategies that, with rare exceptions, focus chiefly on the location of primary research reports and systematic reviews of those reports. These sources are, however, unlikely to adequately address the normative and/or metaphysical questions that nurses frequently and legitimately interest themselves in. To meet these interests, non-research texts exploring normative and/or metaphysical topics might and perhaps should, in some situations, be deemed suitable search targets. This seems plausible and, moreover, students are encouraged to 'read widely'. Yet accepting this proposition creates significant difficulties. Specifically, if non-research scholarly sources and artistic or literary (humanities) products dealing with normative/metaphysical issues were included in what are, at present, scientifically orientated searches, it is difficult to draw boundaries around what--if anything--is to be excluded. Engaging with this issue highlights problems with qualitative scholarship's designation as 'evidence'. Thus, absurdly, if qualitative scholarship's findings are labelled evidence because they generate practice-relevant understanding/insight, then any literary or artistic artefact (e.g. a throwaway lifestyle magazine) that generates kindred understandings/insights is presumably also evidence? This conclusion is rejected and it is instead proposed that while artistic, literary, and qualitative inquiries can provide practitioners with powerful and stimulating non-evidential understanding, these sources are not evidence as commonly conceived.

  7. β-galactosyl Yariv reagent binds to the β-1,3-galactan of arabinogalactan proteins.

    PubMed

    Kitazawa, Kiminari; Tryfona, Theodora; Yoshimi, Yoshihisa; Hayashi, Yoshihiro; Kawauchi, Susumu; Antonov, Liudmil; Tanaka, Hiroshi; Takahashi, Takashi; Kaneko, Satoshi; Dupree, Paul; Tsumuraya, Yoichi; Kotake, Toshihisa

    2013-03-01

    Yariv phenylglycosides [1,3,5-tri(p-glycosyloxyphenylazo)-2,4,6-trihydroxybenzene] are a group of chemical compounds that selectively bind to arabinogalactan proteins (AGPs), a type of plant proteoglycan. Yariv phenylglycosides are widely used as cytochemical reagents to perturb the molecular functions of AGPs as well as for the detection, quantification, purification, and staining of AGPs. However, the target structure in AGPs to which Yariv phenylglycosides bind has not been determined. Here, we identify the structural element of AGPs required for the interaction with Yariv phenylglycosides by stepwise trimming of the arabinogalactan moieties using combinations of specific glycoside hydrolases. Whereas the precipitation with Yariv phenylglycosides (Yariv reactivity) of radish (Raphanus sativus) root AGP was not reduced after enzyme treatment to remove α-l-arabinofuranosyl and β-glucuronosyl residues and β-1,6-galactan side chains, it was completely lost after degradation of the β-1,3-galactan main chains. In addition, Yariv reactivity of gum arabic, a commercial product of acacia (Acacia senegal) AGPs, increased rather than decreased during the repeated degradation of β-1,6-galactan side chains by Smith degradation. Among various oligosaccharides corresponding to partial structures of AGPs, β-1,3-galactooligosaccharides longer than β-1,3-galactoheptaose exhibited significant precipitation with Yariv in a radial diffusion assay on agar. A pull-down assay using oligosaccharides cross linked to hydrazine beads detected an interaction of β-1,3-galactooligosaccharides longer than β-1,3-galactopentaose with Yariv phenylglycoside. To the contrary, no interaction with Yariv was detected for β-1,6-galactooligosaccharides of any length. Therefore, we conclude that Yariv phenylglycosides should be considered specific binding reagents for β-1,3-galactan chains longer than five residues, and seven residues are sufficient for cross linking, leading to precipitation

  8. One-Hundred-km-Scale Basins on Enceladus: Evidence for an Active Ice Shell

    NASA Technical Reports Server (NTRS)

    Schenk, Paul M.; McKinnon, William B.

    2009-01-01

    Stereo-derived topographic mapping of 50% of Enceladus reveals at least 6 large-scale, ovoid depressions (basins) 90-175 km across and 800-to-1500 m deep and uncorrelated with geologic boundaries. Their shape and scale are inconsistent with impact, geoid deflection, or with dynamically supported topography. Isostatic thinning of Enceladus ice shell associated with upwellings (and tidally-driven ice melting) can plausibly account for the basins. Thinning implies upwarping of the base of the shell of 10-20 km beneath the depressions, depending on total shell thickness; loss of near-surface porosity due to enhanced heat flow may also contribute to basin lows. Alternatively, the basins may overly cold, inactive, and hence denser ice, but thermal isostasy alone requires thermal expansion more consistent with clathrate hydrate than water ice. In contrast to the basins, the south polar depression (SPD) is larger (350 wide) and shallower (0.4-to-0.8 km deep) and correlates with the area of tectonic deformation and active resurfacing. The SPD also differs in that the floor is relatively flat (i.e., conforms roughly to the global triaxial shape, or geoid) with broad, gently sloping flanks. The relative flatness across the SPD suggests that it is in or near isostatic equilibrium, and underlain by denser material, supporting the polar sea hypothesis of Collins and Goodman. Near flatness is also predicted by a crustal spreading origin for the "tiger stripes (McKinnon and Barr 2007, Barr 2008); the extraordinary, high CIRS heat flows imply half-spreading rates in excess of 10 cm/yr, a very young surface age (250,000 yr), and a rather thin lithosphere (hence modest thermal topography). Topographic rises in places along the outer margin of the SPD correlate with parallel ridges and deformation along the edge of the resurfaced terrain, consistent with a compressional, imbricate thrust origin for these ridges, driven by the spreading.

  9. Development of a global land cover characteristics database and IGBP DISCover from 1 km AVHRR data

    USGS Publications Warehouse

    Loveland, T.R.; Reed, B.C.; Brown, J.F.; Ohlen, D.O.; Zhu, Z.; Yang, L.; Merchant, J.W.

    2000-01-01

    Researchers from the U.S. Geological Survey, University of Nebraska-Lincoln and the European Commission's Joint Research Centre, Ispra, Italy produced a 1 km resolution global land cover characteristics database for use in a wide range of continental-to global-scale environmental studies. This database provides a unique view of the broad patterns of the biogeographical and ecoclimatic diversity of the global land surface, and presents a detailed interpretation of the extent of human development. The project was carried out as an International Geosphere-Biosphere Programme, Data and Information Systems (IGBP-DIS) initiative. The IGBP DISCover global land cover product is an integral component of the global land cover database. DISCover includes 17 general land cover classes defined to meet the needs of IGBP core science projects. A formal accuracy assessment of the DISCover data layer will be completed in 1998. The 1 km global land cover database was developed through a continent-by-continent unsupervised classification of 1 km monthly Advanced Very High Resolution Radiometer (AVHRR) Normalized Difference Vegetation Index (NDVI) composites covering 1992-1993. Extensive post-classification stratification was necessary to resolve spectral/temporal confusion between disparate land cover types. The complete global database consists of 961 seasonal land cover regions that capture patterns of land cover, seasonality and relative primary productivity. The seasonal land cover regions were aggregated to produce seven separate land cover data sets used for global environmental modelling and assessment. The data sets include IGBP DISCover, U.S. Geological Survey Anderson System, Simple Biosphere Model, Simple Biosphere Model 2, Biosphere-Atmosphere Transfer Scheme, Olson Ecosystems and Running Global Remote Sensing Land Cover. The database also includes all digital sources that were used in the classification. The complete database can be sourced from the website: http://edcwww.cr.usgs.gov/landdaac/glcc/glcc.html.

  10. Metabolic engineering for the production of 1,3-propanediol

    SciTech Connect

    Cameron, D.C.; Tong, I.T., Skraly, F.A.

    1993-12-31

    Metabolic engineering involves the use of recombinant DNA techniques for the modification of intermediary metabolic pathways. Microorganisms have recently been engineered to produce compounds such as indigo, ethanol, fatty acids and polyhydroxyalkanoates. As a model system for research in metabolic engineering, the authors have constructed a strain of the bacterium Escherichia coli, that is able to produce 1,3-propanediol (1,3-PD) from glycerol. This strain contains the genes for the glycerol deydratase and the 1,3-PD oxidoreductase from Klebsiella pneumoniae. The authors have also investigated genetic and environmental strategies for improving the yield and productivity of 1,3-PD by the engineered organism. In addition to being a useful model system, 1,3-PD production is of current practical interest. First 1,3-PD (also known as trimethylene glycol) and 1,4-butanediol, the more readily available diols. Second, the volume of feedstock (glycerol) is expected to grow, as it is a by-product of the production of polyglycoside surfactants and biodiesel fluids.

  11. Debottlenecking the 1,3-propanediol pathway by metabolic engineering.

    PubMed

    Celińska, E

    2010-01-01

    The history of 1,3-propanediol (1,3-PD) conversion from being a specialty chemical to being a bulk chemical illustrates that the concerted effort of different metabolic engineering approaches brings the most successful results. In order to metabolically tailor the 1,3-PD production pathway multiple strategies have been pursued. Knocking-out genes responsible for by-products formation, intergeneric transfer and overexpression of the genes directly involved in the pathway, manipulation with internal redox balance, introduction of a synthetic flux control point, and modification of the substrate mechanism of transport are some of the strategies applied. The metabolic engineering of the microbial 1,3-PD production exploits both native producers and microorganisms with acquired ability to produce the diol via genetic manipulations. Combination of the appropriate genes from homologous and heterologous hosts is expected to bring a desired objective of production of 1,3-PD cheaply, efficiently and independently from non-renewable resources. The state-of-the-art of the 1,3-PD pathway metabolic engineering is reviewed in this paper.

  12. Key enzymes catalyzing glycerol to 1,3-propanediol.

    PubMed

    Jiang, Wei; Wang, Shizhen; Wang, Yuanpeng; Fang, Baishan

    2016-01-01

    Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article. The summary of the main research direction of these three key enzyme and methods of glycerol bioconversion into 1,3-PD and DHA indicates their potential application in future enzymatic research and industrial production, especially in biodiesel industry.

  13. ASIC design in the KM3NeT detector

    NASA Astrophysics Data System (ADS)

    Gajanana, D.; Gromov, V.; Timmer, P.

    2013-02-01

    In the KM3NeT project [1], Cherenkov light from the muon interactions with transparent matter around the detector, is used to detect neutrinos. Photo multiplier tubes (PMT) used as photon sensor, are housed in a glass sphere (aka Optical Module) to detect single photons from the Cherenkov light. The PMT needs high operational voltage ( ~ 1.5 kV) and is generated by a Cockroft-Walton (CW) multiplier circuit. The electronics required to control the PMT's and collect the signals is integrated in two ASIC's namely: 1) a front-end mixed signal ASIC (PROMiS) for the readout of the PMT and 2) an analog ASIC (CoCo) to generate pulses for charging the CW circuit and to control the feedback of the CW circuit. In this article, we discuss the two integrated circuits and test results of the complete setup. PROMiS amplifies the input charge, converts it to a pulse width and delivers the information via LVDS signals. These LVDS signals carry accurate information on the Time of arrival ( < 2 ns) and Time over Threshold. A PROM block provides unique identification to the chip. The chip communicates with the control electronics via an I2C bus. This unique combination of the ASIC's results in a very cost and power efficient PMT base design.

  14. Stratospheric microbiology at 20 km over the Pacific Ocean

    USGS Publications Warehouse

    Smith, David J.; Griffin, Dale W.; Schuerger, Andrew C.

    2010-01-01

    An aerobiology sampling flight at 20 km was conducted on 28 April 2008 over the Pacific Ocean (36.5° N, 118–149° W), a period of time that coincided with the movement of Asian dust across the ocean. The aim of this study was to confirm the presence of viable bacteria and fungi within a transoceanic, atmospheric bridge and to improve the resolution of flight hardware processing techniques. Isolates of the microbial strains recovered were analyzed with ribosomal ribonucleic acid (rRNA) sequencing to identify bacterial species Bacillus sp., Bacillus subtilis, Bacillus endophyticus, and the fungal genus Penicillium. Satellite imagery and ground-based radiosonde observations were used to measure dust movement and characterize the high-altitude environment at the time of collection. Considering the atmospheric residency time (7–10 days), the extreme temperature regime of the environment (-75°C), and the absence of a mechanism that could sustain particulates at high altitude, it is unlikely that our samples indicate a permanent, stratospheric ecosystem. However, the presence of viable fungi and bacteria in transoceanic stratosphere remains relevant to understanding the distribution and extent of microbial life on Earth.

  15. A 233 km Tunnel for Lepton and Hadron Colliders

    NASA Astrophysics Data System (ADS)

    Summers, D. J.; Cremaldi, L. M.; Datta, A.; Duraisamy, M.; Luo, T.; Lyons, G. T.

    2012-07-01

    A decade ago, a cost analysis was conducted to bore a 233 km circumference Very Large Hadron Collider (VLHC) tunnel passing through Fermilab. Here we outline implementations of $e^+e^-$, $p \\bar{p}$, and $\\mu^+ \\mu^-$ collider rings in this tunnel using recent technological innovations. The 240 and 500 GeV $e^+e^-$ colliders employ Crab Waist Crossings, ultra low emittance damped bunches, short vertical IP focal lengths, superconducting RF, and low coercivity, grain oriented silicon steel/concrete dipoles. Some details are also provided for a high luminosity 240 GeV $e^+ e^-$ collider and 1.75 TeV muon accelerator in a Fermilab site filler tunnel. The 40 TeV $p \\bar{p}$ collider uses the high intensity Fermilab $\\bar{p}$ source, exploits high cross sections for $p \\bar{p}$ production of high mass states, and uses 2 Tesla ultra low carbon steel/YBCO superconducting magnets run with liquid neon. The 35 TeV muon ring ramps the 2 Tesla superconducting magnets at 9 Hz every 0.4 seconds, uses 250 GV of superconducting RF to accelerate muons from 1.75 to 17.5 TeV in 63 orbits with 71% survival, and mitigates neutrino radiation with phase shifting, roller coaster motion in a FODO lattice.

  16. KM3NeT Digital Optical Module electronics

    NASA Astrophysics Data System (ADS)

    Real, Diego

    2016-04-01

    The KM3NeT collaboration is currently building of a neutrino telescope with a volume of several cubic kilometres at the bottom of the Mediterranean Sea. The telescope consists of a matrix of Digital Optical Modules that will detect the Cherenkov light originated by the interaction of the neutrinos in the proximity of the detector. This contribution describes the main components of the read-out electronics of the Digital Optical Module: the Power Board, which delivers all the power supply required by the Digital Optical Molule electronics; the Central Logic Board, the main core of the read-out system, hosting 31 Time to Digital Converters with 1 ns resolution and the White Rabbit protocol embedded in the Central Logic Board Field Programmable Gate Array; the Octopus boards, that transfer the Low Voltage Digital Signals from the PMT bases to the Central Logic Board and finally the PMT bases, in charge of converting the analogue signal produced in the 31 3" PMTs into a Low Voltage Digital Signal.

  17. A 233 km tunnel for lepton and hadron colliders

    SciTech Connect

    Summers, D. J.; Cremaldi, L. M.; Datta, A.; Duraisamy, M.; Luo, T.; Lyons, G. T.

    2012-12-21

    A decade ago, a cost analysis was conducted to bore a 233 km circumference Very Large Hadron Collider (VLHC) tunnel passing through Fermilab. Here we outline implementations of e{sup +}e{sup -}, pp-bar , and {mu}{sup +}{mu}{sup -} collider rings in this tunnel using recent technological innovations. The 240 and 500 GeV e{sup +}e{sup -} colliders employ Crab Waist Crossings, ultra low emittance damped bunches, short vertical IP focal lengths, superconducting RF, and low coercivity, grain oriented silicon steel/concrete dipoles. Some details are also provided for a high luminosity 240 GeV e{sup +}e{sup -} collider and 1.75 TeV muon accelerator in a Fermilab site filler tunnel. The 40 TeV pp-bar collider uses the high intensity Fermilab p-bar source, exploits high cross sections for pp-bar production of high mass states, and uses 2 Tesla ultra low carbon steel/YBCO superconducting magnets run with liquid neon. The 35 TeV muon ring ramps the 2 Tesla superconducting magnets at 9 Hz every 0.4 seconds, uses 250 GV of superconducting RF to accelerate muons from 1.75 to 17.5 TeV in 63 orbits with 71% survival, and mitigates neutrino radiation with phase shifting, roller coaster motion in a FODO lattice.

  18. Lewis base catalyzed 1,3-dithiane addition to carbonyl and imino compounds using 2-trimethylsilyl-1,3-dithiane.

    PubMed

    Michida, Makoto; Mukaiyama, Teruaki

    2008-09-01

    Lewis base-catalyzed 1,3-dithiane addition to electrophiles such as carbonyl compounds and N-substituted aldimines with 2-trimethylsilyl-1,3-dithiane (TMS-dithiane) is described. By the activation of the carbon-silicon bond in the presence of a Lewis base catalyst such as tetrabutylammonium phenoxide (PhONnBu(4)), a 1,3-dithiane addition reaction proceeded smoothly to afford the corresponding adducts in good to high yields under mild conditions. This synthesis is also applied to the reactions of ketones having alpha-protons, and of N-substituted aldimines.

  19. X-Ray structure investigation of 1,3-indandione and 1,3-dicyanomethyleneindan derivatives: A review

    NASA Astrophysics Data System (ADS)

    Chetkina, L. A.; Belsky, V. K.

    2008-07-01

    This paper generalizes the results of the X-ray structure investigations of crystals of the 1,3-indandione and 1,3-dicyanomethyleneindan derivatives (primarily, individual compounds, as well as crystal hydrates, crystal solvates, ionic salts, and betaine-like intraionic derivatives of 1,3-indandione). The structural features of molecules and crystals, the geometric parameters, and the intramolecular and intermolecular hydrogen bonds are discussed. Structural formulas of 92 compounds and selected geometric parameters of molecules and hydrogen bonds are presented in six tables.

  20. An isotopic dilution approach for 1,3-butadiene tailpipe emissions and ambient air monitoring.

    PubMed

    Riservato, Manuela; Rolla, Antonio; Davoli, Enrico

    2004-01-01

    An isotopic dilution approach for 1,3-butadiene analysis in gaseous samples is presented. The methodology is based on active sampling on sorbent tubes and subsequent analysis by thermal desorption into a gas chromatography/mass spectrometry system. By adding a perdeuterated internal standard onto the sorbent tubes before sampling, and using mass spectrometric detection, the methodology gives high accuracy for this unstable analyte. The method has been used to monitor 1,3-butadiene ambient air concentrations in a residential area in proximity to a heavy-traffic roadway over a one-week period, for comparison with other traffic-related pollutants analysed by standard procedures. It has also been used to determine tailpipe emissions of two vehicles by standard emission testing procedures in a dynamometer. These vehicles were chosen as examples of low- and high-end emission rate vehicles, i.e., an old no-catalytic converter Otto engine and a new direct-injection diesel engine with catalytic converter. Exhaust gas emissions were 0.052 and 35.85 mg/km, reflecting differences in fuel, engine design, age, and presence (or not) of a catalytic abatement system. The ambient air results showed a weekly average concentration of 1,3-butadiene of 0.53 microg/m(3).

  1. Improved electrolyte and its application in LiNi1/3Mn1/3Co1/3O2-Graphite full cells

    NASA Astrophysics Data System (ADS)

    Liu, Minghong; Dai, Fang; Ma, Zhiru; Ruthkosky, Marty; Yang, Li

    2014-12-01

    Lithium oxalatodifluoroborate (LiODFB) has been synthesized and used as a novel electrolyte additive. Standard and modified electrolytes were flame-sealed in NMR tubes and stored at 60 °C for 3 months. Multiple nuclear NMR (1H, 11B, 13C, 19F, 31P) studies confirmed that the modified electrolyte (2% LiODFB added) showed no signs of decomposition as that of regular electrolyte, which is possibly due to the -F of LiPF6 and oxalate of LiODFB ligand exchange effect. The high temperature stabilization mechanism of the added LiODFB was studied using quantum mechanical calculations. Electrochemical tests of LiNi1/3Mn1/3Co1/3O2 (NMC)-Graphite full-cells with and without LiODFB as the electrolyte additive were conducted. When cycling with the NMC-Graphite full-cell at elevated temperature (60 °C), the 100th cycle capacity retention rate of the modified electrolyte was 60%, compared to 27% with the standard electrolyte. The EIS study indicates the full-cells with LiODFB have much lower interfacial impedance than the standard cells. Theoretical calculations reveal that LiODFB generates a layer of thin and resilient SEI on the graphite surface at a higher reduction potential than ethylene carbonate (EC) due to its higher ring strain and protects graphite from the toxic Mn2+ resulting in improved electrochemical performance of NMC-Graphite based cells.

  2. Impact of morphological changes of LiNi1/3Mn1/3Co1/3O2 on lithium-ion cathode performances

    NASA Astrophysics Data System (ADS)

    Cabelguen, Pierre-Etienne; Peralta, David; Cugnet, Mikael; Maillet, Pascal

    2017-04-01

    Major advances in Li-ion battery technology rely on the nanostructuration of active materials to overcome the severe kinetics limitations of new - cheaper and safer - chemistries. However, opening porosities results in the decrease of volumetric performances, closing the door to significant applications such as portable electronics, electromobility, and grid storage. In this study, we analyze the link between morphologies and performances of model LiNi1/3Mn1/3Co1/3O2 materials. By quantifying exhaustively their microstructures using nitrogen adsorption, mercury intrusion porosimetry, and helium pycnometry, we can discuss how porosities and surface areas are linked to the electrochemical behavior. There is no geometrical parameters that can predict the performances of all our materials. The shape of agglomeration dictates the electrochemical behavior. A huge drop in volumetric performances is measured when microstructure is considered. We show that gravimetric and volumetric power performances are contrary to each other. Highly dense materials exhibit, by far, the best power performances in terms of volumetric figures, so that opening porosities might not be the best strategy, even in non-nanosized materials, for Li-ion battery technology.

  3. Asymmetric Penetration of Shocked Solar Wind Down to 400-km Altitudes at Mars

    NASA Astrophysics Data System (ADS)

    Matsunaga, K.; Seki, K.; Hara, T.; Brain, D. A.

    2014-12-01

    The solar wind interaction with a planetary atmosphere produces the magnetic pile-up region near the planet. The Martian magnetic pile-up region prevents direct penetration of shocked solar wind (magnetosheath) plasma and the penetration boundary is typically located at altitudes above 800 km. Spacecraft measurements have shown, however, that magnetosheath plasma occasionally penetrates into low altitudes below 400 km. Here we used Mars Global Surveyor magnetic field and electron observations during the period from April 1999 to November 2006 to investigate the magnetosheath penetration events. We identified 240 events and found that both solar wind dynamic pressure (Psw) and the orientation of the interplanetary magnetic field (IMF) control the occurrence of the events. The magnetosheath penetration events during the low Psw periods tend to be distributed in low latitudes of the northern hemisphere where the crustal magnetic field is weak, while the event locations widely distributed in terms of the latitude under high Psw conditions. During the low Psw periods, a remarkable feature is that the observational probability is approximately 7 times larger during periods of the "away" IMF sector than during the "toward" sector. These results thus indicate that the magnetosheath penetrations into Martian upper atmosphere more often occur in the upward electric field hemisphere than in the downward electric field hemisphere. Large-amplitude undulation excited by the Kelvin-Helmholtz instability in the upward electric field hemisphere previously suggested from global hybrid simulation can be one of candidate processes to cause the asymmetric penetration during low Psw periods.

  4. Monitoring massive fracture growth at 2-km depths using surface tiltmeter arrays

    USGS Publications Warehouse

    Wood, M.D.

    1979-01-01

    Tilt due to massive hydraulic fractures induced in sedimentary rocks at depths of up to 2.2 km have been recorded by surface tiltmeters. Injection of fluid volumes up to 4 ?? 105 liters and masses of propping agent up to 5 ?? 105 kg is designed to produce fractures approximately 1 km long, 50-100 m high and about 1 cm wide. The surface tilt data adequately fit a dislocation model of a tensional fault in a half-space. Theoretical and observational results indicate that maximum tilt occurs at a distance off the strike of the fracture equivalent to 0.4 of the depth to the fracture. Azimuth and extent of the fracture deduced from the geometry of the tilt field agree with other kinds of geophysical measurements. Detailed correlation of the tilt signatures with pumping parameters (pressure, rate, volume, mass) have provided details on asymmetry in geometry and growth rate. Whereas amplitude variations in tilt vary inversely with the square of the depth, changes in flow rate or pressure gradient can produce a cubic change in width. These studies offer a large-scale experimental approach to the study of problems involving fracturing, mass transport, and dilatancy processes. ?? 1979.

  5. Shuttle high resolution accelerometer package experiment results - Atmospheric density measurements between 60-160 km

    NASA Technical Reports Server (NTRS)

    Blanchard, R. C.; Hinson, E. W.; Nicholson, J. Y.

    1988-01-01

    Indirect or inferred values of atmospheric density encountered by the Shuttle Orbiter during reentry have been calculated from acceleration measurements made by the High Resolution Accelerometer Package (HiRAP) and the Orbiter Inertial Measurement Unit (IMU) liner accelerometers. The atmospheric density data developed from this study represent a significant gain with respect to the body of data collected to date by various techniques in the altitude range of 60 to 160 km. The data are unique in that they cover a very wide horizontal range during each flight and provide insight into the actual density variations encountered along the reentry flight path. The data, which were collected over about 3 years, are also characterized by variations in solar activity, geomagnetic index, and local solar time. Comparison of the flight-derived densities with various atmospheric models have been made, and analyses have attempted to characterize the data and to show correlation with selected physical variables.

  6. 1 GHz, 1 km fiber-optic link for satellite communication integrated terminals

    NASA Astrophysics Data System (ADS)

    Pan, J. J.

    In connection with the growth of satellite communications, demands concerning satellite ground terminals are continuously changing. A description is presented of an integrated terminal concept, using a cost-effective microstrip hybrid integrated circuit, GaAs MESFET, and fiber-optic technology, with complete elimination of waveguide transmission loss. The miniature low-noise front-end, consisting of a single-gate MESFET low-noise amplifier, a dual-gate MESFET active mixer, and an injection laser diode transmitter, is capable of being integrated inside the antenna feed. Through a fiber-optic cable, the downconverter signal is sent to the signal processing facility at a distance of 1 km from the antenna site. The considered link provides the advantages of wide bandwidth, elimination of ground loop and noise pick-up, transmission security, and high-voltage (lightning) isolation.

  7. Study on the performance of electromagnetic particle detectors of LHAASO-KM2A

    NASA Astrophysics Data System (ADS)

    Zhang, Zhongquan; Hou, Chao; Cao, Zhen; Chang, Jingfan; Feng, Cunfeng; Hanapia, Erlan; Gong, Guanghua; Liu, Jia; Lv, Hongkui; Sheng, Xiangdong; Zhang, Shaoru; Zhu, Chengguang

    2017-02-01

    The electromagnetic particle detectors (EDs) for one square kilometer detector array (KM2A) of large high altitude air shower observation (LHAASO) are designed to measure the densities and arrival times of secondary particles in extensive air showers (EASs). ED is a type of plastic scintillator detector with an active area of 1 m2. This study investigates the design and performance of prototype ED. Approximately 20 photoelectrons are collected by the 1st dynode of a photomultiplier tube (PMT). The prototype ED exhibited good detection efficiency and time resolution. The detection for the wide dynamic particle density varying from 1 to 10 000 particles/m2 is realized with the design of the PMT divider for the readout of both the anode and 6th dynode.

  8. File Specification for the 7-km GEOS-5 Nature Run, Ganymed Release Non-Hydrostatic 7-km Global Mesoscale Simulation

    NASA Technical Reports Server (NTRS)

    da Silva, Arlindo M.; Putman, William; Nattala, J.

    2014-01-01

    This document describes the gridded output files produced by a two-year global, non-hydrostatic mesoscale simulation for the period 2005-2006 produced with the non-hydrostatic version of GEOS-5 Atmospheric Global Climate Model (AGCM). In addition to standard meteorological parameters (wind, temperature, moisture, surface pressure), this simulation includes 15 aerosol tracers (dust, sea-salt, sulfate, black and organic carbon), O3, CO and CO2. This model simulation is driven by prescribed sea-surface temperature and sea-ice, daily volcanic and biomass burning emissions, as well as high-resolution inventories of anthropogenic sources. A description of the GEOS-5 model configuration used for this simulation can be found in Putman et al. (2014). The simulation is performed at a horizontal resolution of 7 km using a cubed-sphere horizontal grid with 72 vertical levels, extending up to to 0.01 hPa (approximately 80 km). For user convenience, all data products are generated on two logically rectangular longitude-latitude grids: a full-resolution 0.0625 deg grid that approximately matches the native cubed-sphere resolution, and another 0.5 deg reduced-resolution grid. The majority of the full-resolution data products are instantaneous with some fields being time-averaged. The reduced-resolution datasets are mostly time-averaged, with some fields being instantaneous. Hourly data intervals are used for the reduced-resolution datasets, while 30-minute intervals are used for the full-resolution products. All full-resolution output is on the model's native 72-layer hybrid sigma-pressure vertical grid, while the reduced-resolution output is given on native vertical levels and on 48 pressure surfaces extending up to 0.02 hPa. Section 4 presents additional details on horizontal and vertical grids. Information of the model surface representation can be found in Appendix B. The GEOS-5 product is organized into file collections that are described in detail in Appendix C. Additional

  9. Kinematics of the New Zealand plate boundary: Relative motion by GPS across networks of 1000 km and 50 km spacing

    NASA Technical Reports Server (NTRS)

    Meertens, Charles M.; Rocken, Christian; Perin, Barbara; Walcott, Richard

    1993-01-01

    The NASA/DOSE 'Kinematics of the New Zealand Plate Boundary' experiment is a four-year cooperative Global Positioning System (GPS) experiment involving 6 universities and institutions in New Zealand and the United States. The investigation covers two scales, the first on the scale of plates (approximately 1000 km) and the second is on the scale of the plate boundary zone (approximately 50 km). In the first portion of the experiment, phase A, the objective is to make direct measurements of tectonic plate motion between the Australian and Pacific plates using GPS in order to determine the Euler vector of this plate pair. The phase A portion of this experiment was initiated in December 1992 with the first-epoch baseline measurements on the large scale network. The network will be resurveyed two years later to obtain velocities. The stations which were observed for phase A are shown and listed. Additional regional stations which will be used for this study are listed and are part of either CIGNET or other global tracking networks. The phase A portion of the experiment is primarily the responsibility of the UNAVCO investigators. Therefore, this report concentrates on phase A. The first year of NASA funding for phase A included only support for the field work. Processing and analysis will take place with the second year of funding. The second part of the experiemnt measured relative motion between the Australian and Pacific plates across the pate boundary zone between Hokitika and Christchurch on the South Island of New Zealand. The extent and rate of deformation will be determined by comparisons with historical, conventional surveys and by repeated GPS measurements to be made in two years. This activity was the emphasis of the LDGO portion of the study. An ancillary experiment, phase C, concentrated on plate boundary deformation in the vicinity of Wellington and was done as part of training during the early portion of the field campaign. Details of the objectives of the

  10. Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4-thiadiazole derivatives.

    PubMed

    Santagati, M; Modica, M; Santagati, A; Russo, F; Caruso, A; Cutuli, V; Di Pietro, E; Amico-Roxas, M

    1994-12-01

    The reaction of the 2-amino-substituted 1,3,4-oxadiazoles 9, 10 and the benzothiazoles 11, 12 with ethyl cyanoacetate is described. The obtained cyanoacetamide derivatives 13-16 gave the benzylidene derivatives 18-21 by condensation with benzaldehyde. 2-Phenyl-5-amino-1,3,4-oxadiazolo[3,2-a]pyrimidin-7-one (17) was also obtained. Moreover, the preparation of 6,7,8,9-tetraydro-5H-1,3,4-thiadiazolo[2,3-b]quinazolin++ +-5-thio-derivatives 22-25 and N-(1,3,4-thiadiazol-2-yl-5-substituted)-3,4-5,6-tetrahydro-anthran ilic acids 26-29 is also described. All above compounds and compounds, related to them, 1-8 were tested for their analgesic and antiinflammatory activities and the pharmacological screening results are reported and discussed.

  11. Occupational exposure of workers to 1,3-butadiene.

    PubMed Central

    Fajen, J M; Roberts, D R; Ungers, L J; Krishnan, E R

    1990-01-01

    Researchers from the National Institute for Occupational Safety and Health (NIOSH) conducted an extent-of-exposure study of the 1,3-butadiene monomer, polymer, and end-user industries to determine the size of the exposed workforce, evaluate control technologies and personal protective equipment programs, and assess occupational exposure to 1,3-butadiene. A new analytical method was developed for 1,3-butadiene that increased the sensitivity and selectivity of the previous NIOSH method. The new method is sensitive to 0.2 microgram per 1,3-butadiene sample. Walk-through surveys were conducted in 11 monomer, 17 polymer, and 2 end-user plants. In-depth industrial hygiene surveys were conducted at 4 monomer, 5 polymer, and 2 end-user plants. Airborne exposure concentrations of 1,3-butadiene were determined using personal sampling for each job category. A total of 692 full shift and short-term personnel and 259 area air samples were examined for the presence of 1,3-butadiene. Sample results indicated that all worker exposures were well below the current OSHA PEL of 1000 ppm. Exposures ranged from less than 0.006 ppm to 374 ppm. The average exposure for all samples was less than 2 ppm. The present American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value for 1,3-butadiene is 10 ppm. To reduce the potential for occupational exposure, it is recommended that quality control sampling be conducted using a closed loop system. Also all process pumps should be retrofitted with dual mechanical seals, magnetic gauges should be used in loading and unloading rail cars, and engineering controls should be designed for safely voiding quality control cylinders. PMID:2401251

  12. Are Cav1.3 pacemaker channels in chromaffin cells?

    PubMed Central

    Striessnig, Joerg

    2011-01-01

    Mouse and rat chromaffin cells (MCCs, RCCs) fire spontaneously at rest and their activity is mainly supported by the two L-type Ca2+ channels expressed in these cells (Cav1.2 and Cav1.3). Using Cav1.3−/− KO MCCs we have shown that Cav1.3 possess all the prerequisites for carrying subthreshold currents that sustain low frequency cell firing near resting (0.5 to 2 Hz at −50 mV):1 low-threshold and steep voltage dependence of activation, slow and incomplete inactivation during pulses of several hundreds of milliseconds. Cav1.2 contributes also to pacemaking MCCs and possibly even Na+ channels may participate in the firing of a small percentage of cells. We now show that at potentials near resting (−50 mV), Cav1.3 carries equal amounts of Ca2+ current to Cav1.2 but activates at 9 mV more negative potentials. MCCs express only TTX-sensitive Nav1 channels that activate at 24 mV more positive potentials than Cav1.3 and are fully inactivating. Their blockade prevents the firing only in a small percentage of cells (13%). This suggests that the order of importance with regard to pacemaking MCCs is: Cav1.3, Cav1.2 and Nav1. The above conclusions, however, rely on the proper use of DHPs, whose blocking potency is strongly holding potential dependent. We also show that small increases of KCl concentration steadily depolarize the MCCs causing abnormally increased firing frequencies, lowered and broadened AP waveforms and an increased facility of switching “non-firing” into “firing” cells that may lead to erroneous conclusions about the role of Cav1.3 and Cav1.2 as pacemaker channels in MCCs.2 PMID:21406973

  13. Occupational exposure of workers to 1,3-butadiene.

    PubMed

    Fajen, J M; Roberts, D R; Ungers, L J; Krishnan, E R

    1990-06-01

    Researchers from the National Institute for Occupational Safety and Health (NIOSH) conducted an extent-of-exposure study of the 1,3-butadiene monomer, polymer, and end-user industries to determine the size of the exposed workforce, evaluate control technologies and personal protective equipment programs, and assess occupational exposure to 1,3-butadiene. A new analytical method was developed for 1,3-butadiene that increased the sensitivity and selectivity of the previous NIOSH method. The new method is sensitive to 0.2 microgram per 1,3-butadiene sample. Walk-through surveys were conducted in 11 monomer, 17 polymer, and 2 end-user plants. In-depth industrial hygiene surveys were conducted at 4 monomer, 5 polymer, and 2 end-user plants. Airborne exposure concentrations of 1,3-butadiene were determined using personal sampling for each job category. A total of 692 full shift and short-term personnel and 259 area air samples were examined for the presence of 1,3-butadiene. Sample results indicated that all worker exposures were well below the current OSHA PEL of 1000 ppm. Exposures ranged from less than 0.006 ppm to 374 ppm. The average exposure for all samples was less than 2 ppm. The present American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit value for 1,3-butadiene is 10 ppm. To reduce the potential for occupational exposure, it is recommended that quality control sampling be conducted using a closed loop system. Also all process pumps should be retrofitted with dual mechanical seals, magnetic gauges should be used in loading and unloading rail cars, and engineering controls should be designed for safely voiding quality control cylinders.

  14. A high resolution (1 km) groundwater model for Indonesia

    NASA Astrophysics Data System (ADS)

    Sutanudjaja, Edwin; Verkaik, Jarno; de Graaf, Inge; van Beek, Rens; Erkens, Gilles; Bierkens, Marc

    2015-04-01

    Groundwater is important in many parts of Indonesia. It serves as a primary source of drinking water and industrial activities. During times of drought, it sustains water flows in streams, rivers, lakes and wetlands, and thus support ecosystem habitat and biodiversity as well as preventing hazardous forest fire. Besides its importance, groundwater is known as a vulnerable resource as unsustainable groundwater exploitation and management occurs in many areas of the country. Therefore, in order to ensure sustainable management of groundwater resources, monitoring and predicting groundwater changes in Indonesia are imperative. However, large extent groundwater models to assess these changes on a regional scale are almost non-existent and are hampered by the strong topographical and lithological transitions that characterize Indonesia. In this study, we built an 1 km resolution groundwater model for the entire Indonesian archipelago (total inland area: about 2 million km2). We adopted the approaches of Sutanudjaja et al. (2011, 2014a) and de Graaf et al. (2014) in order to make a MODFLOW (Harbaugh et al., 2000) groundwater model by using only global datasets. Aquifer schematization and properties of the groundwater model were developed from available global lithological maps (e.g. Dürr et al., 2005; Gleeson et al., 2011; Hartmann & Moorsdorf, 2012; Gleeson et al., 2014). We forced the groundwater model with the recent output of global hydrological model PCR-GLOBWB version 2.0 (Sutanudjaja et al., 2014b; van Beek et al., 2011), specifically the long term average of groundwater recharge and average surface water levels derived from channel discharge. Simulation results were promising. The MODFLOW model converged with realistic aquifer properties (i.e. transmissivities) and produced reasonable groundwater head spatial distribution reflecting the positions of major groundwater bodies and surface water bodies in the country. In Vienna, we aim to show and demonstrate these

  15. Gastrointestinal distress is common during a 161-km ultramarathon.

    PubMed

    Stuempfle, Kristin Jean; Hoffman, Martin Dean

    2015-01-01

    This study examined the incidence, severity, and timing of gastrointestinal (GI) symptoms in finishers and non-finishers of the 161-km Western States Endurance Run. A total of 272 runners (71.0% of starters) completed a post-race questionnaire that assessed the incidence and severity (none = 0, mild = 1, moderate = 2, severe = 3, very severe = 4) of 12 upper (reflux/heartburn, belching, stomach bloating, stomach cramps/pain, nausea, vomiting) and lower (intestinal cramps/pain, flatulence, side ache/stitch, urge to defecate, loose stool/diarrhoea, intestinal bleeding/bloody faeces) GI symptoms experienced during each of four race segments. GI symptoms were experienced by most runners (96.0%). Flatulence (65.9% frequency, mean value 1.0, s = 0.6 severity), belching (61.3% frequency, mean value 1.0, s = 0.6 severity), and nausea (60.3% frequency, mean value 1.0, s = 0.7 severity) were the most common symptoms. Among race finishers, 43.9% reported that GI symptoms affected their race performance, with nausea being the most common symptom (86.0%). Among race non-finishers, 35.6% reported that GI symptoms were a reason for dropping out of the race, with nausea being the most common symptom (90.5%). For both finishers and non-finishers, nausea was greatest during the most challenging and hottest part of the race. GI symptoms are very common during ultramarathon running, and in particular, nausea is the most common complaint for finishers and non-finishers.

  16. Processing techniques for global land 1-km AVHRR data

    USGS Publications Warehouse

    Eidenshink, Jeffery C.; Steinwand, Daniel R.; Wivell, Charles E.; Hollaren, Douglas M.; Meyer, David

    1993-01-01

    The U.S. Geological Survey's (USGS) Earth Resources Observation Systems (EROS) Data Center (EDC) in cooperation with several international science organizations has developed techniques for processing daily Advanced Very High Resolution Radiometer (AVHRR) 1-km data of the entire global land surface. These techniques include orbital stitching, geometric rectification, radiometric calibration, and atmospheric correction. An orbital stitching algorithm was developed to combine consecutive observations acquired along an orbit by ground receiving stations into contiguous half-orbital segments. The geometric rectification process uses an AVHRR satellite model that contains modules for forward mapping, forward terrain correction, and inverse mapping with terrain correction. The correction is accomplished by using the hydrologic features coastlines and lakes from the Digital Chart of the World. These features are rasterized into the satellite projection and are matched to the AVHRR imagery using binary edge correlation techniques. The resulting coefficients are related to six attitude correction parameters: roll, roll rate, pitch, pitch rate, yaw, and altitude. The image can then be precision corrected to a variety of map projections and user-selected image frames. Because the AVHRR lacks onboard calibration for the optical wavelengths, a series of time-variant calibration coefficients derived from vicarious calibration methods and are used to model the degradation profile of the instruments. Reducing atmospheric effects on AVHRR data is important. A method has been develop that will remove the effects of molecular scattering and absorption from clear sky observations, using climatological measurements of ozone. Other methods to remove the effects of water vapor and aerosols are being investigated.

  17. Estimation of Land Surface Temperature from 1-km AVHRR data

    NASA Astrophysics Data System (ADS)

    Frey, Corinne

    2016-04-01

    In order to re-process DLRs 1km AVHRR data archive to different geophysical and descriptive parameters of the land surface and the atmosphere, a series of scientific data processors are being developed in the framework of the TIMELINE project. The archive of DLR ranges back to the 80ies. One of the data processors is SurfTemp, which processes L2 LST and emissivity datasets from AVHRR L1b data. The development of the data processor included the selection of statistical procedures suitable for time series processing, including four mono-window and six split window algorithms. For almost all of these algorithms, new constants were generated, which better account for different atmospheric and geometric acquisition situations. The selection of optimal algorithms for SurfTemp is based on a round robin approach, in which the selected mono-window and split window algorithms are tested on the basis of a large number of TOA radiance/LST pairs, which were generated using a radiative transfer model and the SeeBorV5 profile database. The original LSTs are thereby compared to the LSTs derived from the TOA radiances using the mono- and split window algorithms. The algorithm comparison includes measures of precision, as well as the sensitivity of a method to the accuracy of its input data. The results of the round robin are presented, as well as the implementation of selected algorithms into SurfTemp. Further, first cross-validation results between the AVHRR LST and MODIS LST are shown.

  18. Determinants of recovery from a 161-km ultramarathon.

    PubMed

    Hoffman, Martin D; Badowski, Natalie; Chin, Joseph; Stuempfle, Kristin J; Parise, Carol A

    2017-04-01

    The primary study objective was to identify determinants of short-term recovery from a 161-km ultramarathon. Participants completed 400 m runs at maximum speed before the race and on days 3 and 5 post-race, provided a post-race blood sample for plasma creatine kinase (CK) concentration, and provided lower body muscle pain and soreness ratings (soreness, 10-point scale) and overall muscular fatigue scores (fatigue, 100-point scale) pre-race and for 7 days post-race. Among 72 race finishers, soreness and fatigue had statistically returned to pre-race levels by 5 days post-race; and 400 m times at days 3 and 5 remained 26% (P = 0.001) and 12% (P = 0.01) slower compared with pre-race, respectively. CK best modelled soreness, fatigue and per cent change in post-race 400 m time. Runners with the highest CKs had 1.5 points higher (P < 0.001) soreness and 11.2 points higher (P = 0.006) fatigue than runners with the lowest CKs. For the model of 400 m time, a significant interaction of time with CK (P < 0.001) indicates that higher CKs were linked with a slower rate of return to pre-race 400 m time. Since post-race CK was the main modifiable determinant of recovery following the ultramarathon, appropriate training appears to be the optimal approach to enhance ultramarathon recovery.

  19. Klebsiella pneumoniae 1,3-propanediol:NAD+ oxidoreductase.

    PubMed Central

    Johnson, E A; Lin, E C

    1987-01-01

    Fermentative utilization of glycerol, a more reduced carbohydrate than aldoses and ketoses, requires the disposal of the two extra hydrogen atoms. This is accomplished by sacrificing an equal quantity of glycerol via an auxiliary pathway initiated by glycerol dehydratase. The product, 3-hydroxypropionaldehyde, is then reduced by 1,3-propanediol NAD+:oxidoreductase (1,3-propanediol dehydrogenase; EC 1.1.1.202), resulting in the regeneration of NAD+ from NADH. The pathway for the assimilation of glycerol is initiated by an NAD-linked dehydrogenase. In Klebsiella pneumoniae the two pathways are encoded by the dha regulon which is inducible only anaerobically. In this study 1,3-propanediol:NAD+ oxidoreductase was purified from cells grown anaerobically on glycerol. The enzyme was immunochemically distinct from the NAD-linked glycerol dehydrogenase and was an octamer or hexamer of a polypeptide of 45,000 +/- 3,000 daltons. When tested as a dehydrogenase, only 1,3-propanediol served as a substrate; no activity was detected with ethanol, 1-propanol, 1,2-propanediol, glycerol, or 1,4-butanediol. The enzyme was inhibited by chelators of divalent cations. An enzyme preparation inhibited by alpha,alpha'-dipyridyl was reactivated by the addition of Fe2+ or Mn2+ after removal of the chelator by gel filtration. As for glycerol dehydrogenase, 1,3-propanediol oxidoreductase is apparently inactivated by oxidation during aerobic metabolism, under which condition the enzyme becomes superfluous. Images PMID:3553154

  20. Wide Angle Michelson Doppler Imaging Interferometer (WAMDII)

    NASA Technical Reports Server (NTRS)

    Roberts, W. T.

    1985-01-01

    The wide angle Michelson Doppler imaging interferometer (WAMDII) is a specialized type of optical Michelson interferometer working at sufficiently long path difference to measure Doppler shifts and to infer Doppler line widths of naturally occurring upper atmospheric Gaussian line emissions. The instrument is intended to measure vertical profiles of atmospheric winds and temperatures within the altitude range of 85 km to 300 km. The WAMDII consists of a Michelson interferometer followed by a camera lens and an 85 x 106 charge coupled device photodiode array. Narrow band filters in a filter wheel are used to isolate individual line emissions and the lens forms an image of the emitting region on the charge coupled device array.

  1. Wide Angle Michelson Doppler Imaging Interferometer (WAMDII)

    NASA Technical Reports Server (NTRS)

    Roberts, B.

    1986-01-01

    The wide angle Michelson Doppler imaging interferometer (WAMDII) is a specialized type of optical Michelson interferometer working at sufficiently long path difference to measure Doppler shifts and to infer Doppler line widths of naturally occurring upper atmospheric Gaussian line emissions. The instrument is intended to measure vertical profiles of atmospheric winds and temperatures within the altitude range of 85 km to 300 km. The WAMDII consists of a Michelson interferometer followed by a camera lens and an 85 x 106 charge coupled device photodiode array. Narrow band filters in a filter wheel are used to isolate individual line emissions and the lens forms an image of the emitting region on the charge coupled device array.

  2. Clouds in ECMWF's 30 KM Resolution Global Atmospheric Forecast Model (TL639)

    NASA Technical Reports Server (NTRS)

    Cahalan, R. F.; Morcrette, J. J.

    1999-01-01

    Global models of the general circulation of the atmosphere resolve a wide range of length scales, and in particular cloud structures extend from planetary scales to the smallest scales resolvable, now down to 30 km in state-of-the-art models. Even the highest resolution models do not resolve small-scale cloud phenomena seen, for example, in Landsat and other high-resolution satellite images of clouds. Unresolved small-scale disturbances often grow into larger ones through non-linear processes that transfer energy upscale. Understanding upscale cascades is of crucial importance in predicting current weather, and in parameterizing cloud-radiative processes that control long term climate. Several movie animations provide examples of the temporal and spatial variation of cloud fields produced in 4-day runs of the forecast model at the European Centre for Medium-Range Weather Forecasts (ECMWF) in Reading, England, at particular times and locations of simultaneous measurement field campaigns. model resolution is approximately 30 km horizontally (triangular truncation TL639) with 31 vertical levels from surface to stratosphere. Timestep of the model is about 10 minutes, but animation frames are 3 hours apart, at timesteps when the radiation is computed. The animations were prepared from an archive of several 4-day runs at the highest available model resolution, and archived at ECMWF. Cloud, wind and temperature fields in an approximately 1000 km X 1000 km box were retrieved from the archive, then approximately 60 Mb Vis5d files were prepared with the help of Graeme Kelly of ECMWF, and were compressed into MPEG files each less than 3 Mb. We discuss the interaction of clouds and radiation in the model, and compare the variability of cloud liquid as a function of scale to that seen in cloud observations made in intensive field campaigns. Comparison of high-resolution global runs to cloud-resolving models, and to lower resolution climate models is leading to better

  3. Converted phases from sharp 1000 km depth mid-mantle heterogeneity beneath Western Europe

    NASA Astrophysics Data System (ADS)

    Jenkins, J.; Deuss, A.; Cottaar, S.

    2017-02-01

    Until recently, most of the lower mantle was generally considered to be well-mixed with strong heterogeneity restricted to the lowermost several hundred kilometres above the core-mantle boundary, known as the D″ layer. However several recent studies have started to hint at a potential change in Earth's structure at mid-mantle depths beneath the transition zone. Here we present a continental-wide search of Europe and the North Atlantic for mid-mantle P-to-s wave converted phases. Our data set consists of close to 50,000 high quality receiver functions. These are combined in slowness and depth stacks to identify seismic discontinuities in the range of 800-1400 km depth to determine at which depths and in which tectonic settings these features exist. Receiver functions are computed in different frequency bands to resolve the sharpness of the observed discontinuities. We find most seismic velocity jumps are observed between 975-1050 km depth, localised beneath western Europe and Iceland. The shear wave velocity jumps are roughly 1-2.5% velocity increase with depth occurring over less than 8 km in width. The most robust observations are coincident with areas of active upwelling (under Iceland) and an elongate lateral low velocity anomaly imaged in recent tomographic models which has been interpreted as diverted plume material at depth. The lack of any suggested phase change in a normal pyrolitic mantle composition at around 1000 km depth indicates the presence of regional chemical heterogeneity within the mid-mantle, potentially caused by diverted plume material. We hypothesise that our observations represent either a phase change within chemically distinct plume material itself, or are caused by small scale chemical heterogeneities entrained within the upwelling plume, either in the form of recycled basaltic material or deep sourced chemically distinct material from LLSVPs. Our observations, which cannot be directly linked to an area of either active or ancient

  4. Synthesis and Electrochemical Properties Characterization of SnO2-coated LiNi1/3Co1/3Mn1/3O2 Cathode Material for Lithium Ion Batteries

    DTIC Science & Technology

    2009-01-01

    Synthesis and electrochemical properties characterization of SnO2 -coated LiNi1/3Co1/3Mn1/3O2 cathode material for lithium ion batteries Ping Yang...China Key words: Li-ion battery; cathode materials; LiNi1/3Co1/3Mn1/3O2; heterogeneous nucleation; SnO2 -coated; electrochemical performance...Abstract LiNi1/3Co1/3Mn1/3O2 cathode materials have been coated with SnO2 (3% wt) by heterogeneous nucleation process to improve its electrochemical

  5. The isolated ˜680 km deep 30 May 2015 MW 7.9 Ogasawara (Bonin) Islands earthquake

    NASA Astrophysics Data System (ADS)

    Ye, Lingling; Lay, Thorne; Zhan, Zhongwen; Kanamori, Hiroo; Hao, Jin-Lai

    2016-01-01

    Deep-focus earthquakes, located in very high-pressure conditions 300 to 700 km below the Earth's surface within sinking slabs of relatively cold oceanic lithosphere, are mysterious phenomena. The largest recorded deep-focus earthquake (MW 7.9) in the Izu-Bonin slab struck on 30 May 2015 beneath the Ogasawara (Bonin) Islands, isolated from prior seismicity by over 100 km in depth, and followed by only a few small aftershocks. Globally, this is the deepest (680 km centroid depth) event with MW ≥ 7.8 in the seismological record. Seismicity indicates along-strike contortion of the Izu-Bonin slab, with horizontal flattening near a depth of 550 km in the Izu region and rapid steepening to near-vertical toward the south above the location of the 2015 event. This event was exceptionally well-recorded by seismic stations around the world, allowing detailed constraints to be placed on the source process. Analyses of a large global data set of P, SH and pP seismic phases using short-period back-projection, subevent directivity, and broadband finite-fault inversion indicate that the mainshock ruptured a shallowly-dipping fault plane with patchy slip that spread over a distance of ∼40 km with a multi-stage expansion rate (∼ 5 + km /s down-dip initially, ∼3 km/s up-dip later). During the 17 s total rupture duration the radiated energy was ∼ 3.3 ×1016 J and the stress drop was ∼38 MPa. The radiation efficiency is moderate (0.34), intermediate to that of the 1994 Bolivia and 2013 Sea of Okhotsk MW 8.3 deep earthquakes, indicating that source processes of very large deep earthquakes sample a wide range of behavior from dissipative, more viscous failure to very brittle failure. The isolated occurrence of the event, much deeper than the apparently thermally-bounded distribution of Bonin-slab seismicity above 600 km depth, suggests that localized stress concentration associated with the pronounced deformation of the Izu-Bonin slab and proximity to the 660-km phase

  6. 1,3,4-oxadiazole derivatives as potential biological agents.

    PubMed

    Sun, Juan; Makawana, Jigar A; Zhu, Hai-Liang

    2013-10-01

    The synthesis of novel compound libraries along with screening is a rapid and effective approach for the discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4- oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel 1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review, we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their prospects as the potential chemical drugs.

  7. Poly(1,3,4-oxadiazoles) via aromatic nucleophilic displacement

    NASA Technical Reports Server (NTRS)

    Connell, John W. (Inventor); Hergenrother, Paul M. (Inventor); Wolf, Peter (Inventor)

    1992-01-01

    Poly(1,3,4-oxadiazoles) (POX) are prepared by the aromatic nucleophilic displacement reaction of di(hydroxyphenyl) 1,3,4-oxadiazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds. The polymerizations are carried out in polar aprotic solvents such as sulfolane or diphenylsulfone using alkali metal bases such as potassium carbonate at elevated temperatures under nitrogen. The di(hydroxyphenyl) 1,3,4-oxadiazole monomers are synthesized by reacting 4-hydroxybenzoic hydrazide with phenyl 4-hydrobenzoate in the melt and also by reacting aromatic dihydrazides with two moles of phenyl 4-hydroxybenzoate in the melt. This synthetic route has provided high molecular weight POX of new chemical structure, is economically and synthetically more favorable than other routes, and allows for facile chemical structure variation due to the large variety of activated aromatic dihalides which are available.

  8. Electronic structure of 1,3-dioxanes with accepting substituents

    SciTech Connect

    Bresler, I.G.; Akhmatdinov, R.T.; Kantor, E.A.; Rakhmankulov, D.L.

    1987-10-10

    The electronic structure of 1,3-dioxanes with accepting substituents was investigated by photoelectron spectroscopy and the SCF LCAO-MO method in the CNDO/2 approximation. Substituents at positions 2 or 5 reduce the energy of the HOMO of 1,3-dioxane with A' symmetry by 0.4-0.5 eV and the energy of the B1 orbital of A'' symmetry by 0.04-0.15 eV. The HOMO of acceptor-substituted 1,3-dioxanes becomes an orbital of A'' symmetry type. The calculated differences in the energy of the HOMO and the B1 orbital are consistent with the splitting of the first band in the photoelectron spectra.

  9. Assessment of 1,3-butadiene epidemiology studies.

    PubMed Central

    Ott, M G

    1990-01-01

    Positive carcinogenicity studies in mice and rats have led to concerns that 1,3-butadiene may be carcinogenic in humans under exposure conditions that have existed in occupational settings and perhaps exist today. The principal settings of interest are the styrene-butadiene rubber (SBR) manufacturing industry, which uses large quantities of 1,3-butadiene, and the 1,3-butadiene monomer industry. The potential for 1,3-butadiene exposure is highest during monomer transfer operations and is lowest in finishing areas of polymerization plants where the polymer products are processed. Three large cohort mortality studies have been conducted in the SBR and monomer producing industries since 1980. These studies, which examined the mortality experience of over 17,000 men employed in one monomer and 10 SBR facilities, are the subject of this review. All but one of the facilities began operations during the early 1940s. The mortality experience observed within these employee cohorts is comparable to that seen in other long-term studies of men employed in the petroleum, chemical, and rubber industries for all causes of death, total malignant neoplasms, and for the specific cancers seen in excess in the toxicologic studies. This paper discusses discrepant findings observed in more detailed analyses within individual cohorts and among employment subgroups, as well as selected limitations of the particular studies. Additional efforts to refine 1,3-butadiene exposure categories are needed. Within the context of sample size limitations inherent in these studies, there is currently inadequate evidence to establish a relationship between cancer mortality outcomes and 1.3-butadiene exposure in humans. PMID:2205483

  10. The Molecular Gas Environment in the 20 km s‑1 Cloud in the Central Molecular Zone

    NASA Astrophysics Data System (ADS)

    Lu, Xing; Zhang, Qizhou; Kauffmann, Jens; Pillai, Thushara; Longmore, Steven N.; Kruijssen, J. M. Diederik; Battersby, Cara; Liu, Hauyu Baobab; Ginsburg, Adam; Mills, Elisabeth A. C.; Zhang, Zhi-Yu; Gu, Qiusheng

    2017-04-01

    We recently reported a population of protostellar candidates in the 20 km s‑1 cloud in the Central Molecular Zone of the Milky Way, traced by H2O masers in gravitationally bound dense cores. In this paper, we report molecular line studies with high angular resolution (∼3″) of the environment of star formation in this cloud. Maps of various molecular line transitions as well as the continuum at 1.3 mm are obtained using the Submillimeter Array. Five NH3 inversion lines and the 1.3 cm continuum are observed with the Karl G. Jansky Very Large Array. The interferometric observations are complemented with single-dish data. We find that the CH3OH, SO, and HNCO lines, which are usually shock tracers, are better correlated spatially with the compact dust emission from dense cores among the detected lines. These lines also show enhancement in intensities with respect to SiO intensities toward the compact dust emission, suggesting the presence of slow shocks or hot cores in these regions. We find gas temperatures of ≳100 K at 0.1 pc scales based on RADEX modeling of the H2CO and NH3 lines. Although no strong correlations between temperatures and linewidths/H2O maser luminosities are found, in high-angular-resolution maps we note several candidate shock-heated regions offset from any dense cores, as well as signatures of localized heating by protostars in several dense cores. Our findings suggest that at 0.1 pc scales in this cloud star formation and strong turbulence may together affect the chemistry and temperature of the molecular gas.

  11. 112 Gb/s PM-QPSK transmission up to 6000 km with 200 km amplifier spacing and a hybrid fiber span configuration.

    PubMed

    Downie, John D; Hurley, Jason; Cartledge, John; Bickham, Scott; Mishra, Snigdharaj

    2011-12-12

    We demonstrate transmission of 112 Gb/s PM-QPSK signals over a system with 200 km span lengths. Amplification is provided by hybrid backward-pumped Raman/EDFA amplifiers and reach lengths up to 6000 km for an 8 channel system and 5400 km for a 32 channel system are shown. As a means of maximizing OSNR, a simple hybrid fiber span configuration is used that combines two ultra-low loss fibers, one having very large effective area.

  12. Identification and enzymatic characterization of an endo-1,3-β-glucanase from Euglena gracilis.

    PubMed

    Takeda, Takumi; Nakano, Yuki; Takahashi, Machiko; Konno, Naotake; Sakamoto, Yuichi; Arashida, Ryo; Marukawa, Yuka; Yoshida, Eriko; Ishikawa, Takahiro; Suzuki, Kengo

    2015-08-01

    Euglena produces paramylon as a storage polysaccharide, and is thought to require β-1,3-glucan degrading enzymes to release and utilize the accumulated carbohydrate. To investigate β-1,3-glucan degradation in Euglena, endo-1,3-β-glucanases were partially purified from Euglena gracilis by hydrophobic, gel filtration and anion-exchange chromatography. Tryptic digests and mass-spectrometric analysis identified three proteins in the purified fraction as a member of glycoside hydrolase family (GH) 17 and two members of GH81. These genes were cloned from an Euglena cDNA pool by PCR. EgCel17A fused with a histidine-tag at the carboxy terminus was heterologously produced by Aspergillus oryzae and purified by immobilized metal affinity chromatography. Purified EgCel17A had a molecular weight of about 40kDa by SDS-PAGE, which was identical to that deduced from its amino acid sequence. The enzyme showed hydrolytic activity towards β-1,3-glucans such as laminarin and paramylon. Maximum activity of laminarin degradation by EgCel17A was attained at pH 4.0-5.5 and 60°C after 1h incubation or 50°C after 20h incubation. The enzyme had a Km of 0.21mg/ml and a Vmax of 40.5units/mg protein for laminarin degradation at pH 5.0 and 50°C. Furthermore, EgCel17A catalyzed a transglycosylation reaction by which reaction products with a higher molecular weight than the supplied substrates were initially generated; however, ultimately the substrates were degraded into glucose, laminaribiose and laminaritriose. EgCel17A effectively produced soluble β-1,3-glucans from alkaline-treated Euglena freeze-dried powder containing paramylon. Thus, EgCel17 is the first functional endo-1,3-β-glucanase to be identified from E. gracilis.

  13. Voglibose-inspired synthesis of new potent α-glucosidase inhibitors N-1,3-dihydroxypropylaminocyclitols.

    PubMed

    Worawalai, Wisuttaya; Sompornpisut, Pornthep; Wacharasindhu, Sumrit; Phuwapraisirisan, Preecha

    2016-06-24

    Voglibose, an N-1,3-dihydroxypropylaminocyclitol, has widely been used as an effective α-glucosidase inhibitor for diabetes therapy. Several attempts have been made to synthesize closely related analogues through the coupling of various aminocyclitols and propane-1,3-diol; however, most of them showed weaker or no inhibition. In this communication, we synthesized a pair of new N-1,3-dihydroxypropylaminocyclitols (10 and 11) using (+)-proto-quercitol (1) as a cyclitol core structure. The newly synthesized compounds revealed potent rat intestinal α-glucosidases, particularly against maltase, with IC50 values at submicromolar. Subsequent study on mechanisms underlying the inhibition of 11 indicated the competitive manner towards maltase and sucrase. The potent inhibition of these compounds was elaborated by docking study, in which their binding profiles towards key amino acid residues in the active site were similar to that of voglibose. Therefore, introduction of propane-1,3-diol moiety to suitable cyclohexane core structure such as aminoquercitol would be a potential approach to discover a new series of effective α-glucosidase inhibitors.

  14. 21 CFR 173.220 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false 1,3-Butylene glycol. 173.220 Section 173.220 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Solvents, Lubricants, Release Agents...

  15. 31 CFR 1.3 - Publication in the Federal Register.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Publication in the Federal Register... RECORDS Freedom of Information Act § 1.3 Publication in the Federal Register. (a) Requirement. Subject to...), separately state, publish and maintain current in the Federal Register for the guidance of the public...

  16. 31 CFR 1.3 - Publication in the Federal Register.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Publication in the Federal Register... RECORDS Freedom of Information Act § 1.3 Publication in the Federal Register. (a) Requirement. Subject to...), separately state, publish and maintain current in the Federal Register for the guidance of the public...

  17. 31 CFR 1.3 - Publication in the Federal Register.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Publication in the Federal Register... RECORDS Freedom of Information Act § 1.3 Publication in the Federal Register. (a) Requirement. Subject to...), separately state, publish and maintain current in the Federal Register for the guidance of the public...

  18. 31 CFR 1.3 - Publication in the Federal Register.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Publication in the Federal Register... RECORDS Freedom of Information Act § 1.3 Publication in the Federal Register. (a) Requirement. Subject to...), separately state, publish and maintain current in the Federal Register for the guidance of the public...

  19. 29 CFR 1910.1051 - 1,3-Butadiene.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...,3-Butadiene. (a) Scope and application. (1) This section applies to all occupational exposures to 1... enter a regulated area. 1,3-Butadiene means an organic compound with chemical formula CH2=CH-CH=CH2 that... equipped with approved BD or organic vapor cartridges or canisters. Cartridges or canisters shall...

  20. Synthetic Methods for Cyclohexa-1,3-dienes

    NASA Astrophysics Data System (ADS)

    Mironov, V. A.; Fedorovich, A. D.; Akhrem, A. A.

    1983-01-01

    The review gives a systematic account of the methods of synthesis of cyclohexa-1,3-diene, its homologues, and derivatives with functional groups. The purity of the preparations obtained by each method is considered on the basis of modern data. The bibliography includes 221 references.

  1. Diffusion of helium (1); buta-1,3-diene (2)

    NASA Astrophysics Data System (ADS)

    Winkelmann, J.

    This document is part of Subvolume A `Gases in Gases, Liquids and their Mixtures' of Volume 15 `Diffusion in Gases, Liquids and Electrolytes' of Landolt-Börnstein Group IV `Physical Chemistry'. It is part of the chapter of the chapter `Diffusion in Pure Gases' and contains data on diffusion of (1) helium; (2) buta-1,3-diene

  2. Diffusion of buta-1,3-diene (1); air (2)

    NASA Astrophysics Data System (ADS)

    Winkelmann, J.

    This document is part of Subvolume A `Gases in Gases, Liquids and their Mixtures' of Volume 15 `Diffusion in Gases, Liquids and Electrolytes' of Landolt-Börnstein Group IV `Physical Chemistry'. It is part of the chapter of the chapter `Diffusion in Pure Gases' and contains data on diffusion of (1) buta-1,3-diene; (2) air

  3. Radical [1,3]-Rearrangements of Breslow Intermediates

    PubMed Central

    Alwarsh, Sefat; Xu, Yi; Qian, Steven

    2015-01-01

    Breslow intermediates that bear radical stabilizing N-substituents including benzyl, cinnamyl, and diarylmethyl undergo facile homolytic C-N bond scission under mild conditions to give products of formal [1,3]-rearrangement rather than benzoin condensation. EPR experiments and computational analysis support a radical mechanism. Implications for thiamine based enzymes are discussed. PMID:26553753

  4. Cancer risk assessment of 1,3-butadiene.

    PubMed Central

    Cote, I L; Bayard, S P

    1990-01-01

    This paper discusses the Environmental Protection Agency's (EPA) risk assessment of 1,3-butadiene. The assessment focuses on estimation of increased cancer risk to populations living near industrial sources of 1,3-butadiene emissions rather than occupationally exposed populations. Incremental cancer risk estimates based on extrapolation from laboratory animal data are presented. Pharmacokinetic data published since the EPA's 1985 assessment are incorporated, which somewhat alters the earlier assessment of cancer risk. Characterization of emission sources, estimates of ambient air concentrations, and population exposure are also discussed. The estimate presented in this paper of excess cancer cases resulting from point source exposure to 1,3-butadiene is decreased to approximately 40% of the estimate published in 1985 from 6.4 in 10 to 2.5 chances in 10 for a lifetime exposure to 1 ppm. The current estimate is no more than eight additional cancer incidences in the general population. Increased risk to the most exposed individuals is not anticipated to be greater than 1 in 10. This reduction in the risk estimate is due to a change in the estimate of 1,3-butadiene potency (i.e., incremental unit risk estimate) based on incorporation of new pharmacokinetic data. PMID:2205485

  5. Super-Cell Piezoelectric Composite with 1-3 Connectivity.

    PubMed

    Rouffaud, Remi; Levassort, Franck; Phamti, Mai; Bantignies, Claire; Lethiecq, Marc; Hladky-Hennion, Anne-Christine

    2016-09-05

    The standard fabrication method for 1-3 piezocomposites for ultrasound transducers is the « dice and fill » method (DFM) in which lateral periodicity is introduced. This contributes to the appearance of spurious modes which can drastically affect the performance of the device if they appear near its thickness mode frequency, thus limiting the effective frequency range. A new 1-3 piezocomposite fabricated with a super-cell structure (13SC) was designed in order to overcome these limitations. It consists of the merging of several periodic cells with 47% PZT volume fraction and epoxy resin as the matrix. Two lateral periodicities in one direction are defined as well as two different kerfs. The chosen cell shape is composed of five non-aligned square section rods (11mm2). For comparison of performance, two regular 1-3 piezocomposites (same materials and equivalent periodicities) were fabricated by DFM. Electro-acoustic responses in water were measured for the three composites being considered as transducers. Successive regular thinnings (from 2.8 to 1.1 mm) were carried out for each sample to increase the operating frequency (from around 0.4 to 1.3 MHz) and study the evolution of the characteristics (bandwidth and sensitivity). Experimental results confirmed the behavior of those obtained with numerical simulations, showing that the 13SC composite can be used in this entire frequency range, unlike regular composites.

  6. 43 CFR 9239.1-3 - Measure of damages.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) TRESPASS Kinds of Trespass § 9239.1-3... the case of a purchase from a trespasser, if the purchaser has no knowledge of the trespass, but should have had such knowledge through reasonable diligence, the value at the time of the purchase....

  7. 43 CFR 3440.1-3 - Limitations on coal use.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Limitations on coal use. 3440.1-3 Section...-3 Limitations on coal use. (a) A license to mine may be issued to a municipality for the nonprofit mining and disposal of coal to its residents for household use only. Under such a license, a...

  8. 43 CFR 3440.1-3 - Limitations on coal use.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Limitations on coal use. 3440.1-3 Section...-3 Limitations on coal use. (a) A license to mine may be issued to a municipality for the nonprofit mining and disposal of coal to its residents for household use only. Under such a license, a...

  9. 43 CFR 3440.1-3 - Limitations on coal use.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Limitations on coal use. 3440.1-3 Section...-3 Limitations on coal use. (a) A license to mine may be issued to a municipality for the nonprofit mining and disposal of coal to its residents for household use only. Under such a license, a...

  10. 43 CFR 3440.1-3 - Limitations on coal use.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Limitations on coal use. 3440.1-3 Section...-3 Limitations on coal use. (a) A license to mine may be issued to a municipality for the nonprofit mining and disposal of coal to its residents for household use only. Under such a license, a...

  11. Vapor-liquid equilibria of the water + 1,3-propanediol and water + 1,3-propanediol + lithium bromide systems

    SciTech Connect

    Mun, S.Y.; Lee, H.

    1999-12-01

    Vapor-liquid equilibrium data of the water + 1,3-propanediol and water + 1,3-propanediol + lithium bromide systems were measured at 60, 160, 300, and 760 mmHg at temperatures ranging from 315 to 488 K. The apparatus used in this work is a modified still especially designed for the measurement of low-pressure VLE, in which both liquid and vapor are continuously recirculated. For the analysis of salt-containing solutions, a method incorporating refractometry and gravimetry was used. From the experimental measurements, the effect of lithium bromide on the VLE behavior of water + 1,3-propanediol was investigated. The experimental data of the salt-free system were successfully correlated using the Wilson, NRTL, and UNIQUAC models. In addition, the extended UNIQUAC model of Sander et al. was applied to the VLE calculation of salt-containing mixtures.

  12. Synthesis of 1,3-Amino Alcohols, 1,3-Diols, Amines, and Carboxylic Acids from Terminal Alkynes.

    PubMed

    Zeng, Mingshuo; Herzon, Seth B

    2015-09-04

    The half-sandwich ruthenium complexes 1-3 activate terminal alkynes toward anti-Markovnikov hydration and reductive hydration under mild conditions. These reactions are believed to proceed via addition of water to metal vinylidene intermediates (4). The functionalization of propargylic alcohols by metal vinylidene pathways is challenging owing to decomposition of the starting material and catalytic intermediates. Here we show that catalyst 2 can be employed to convert propargylic alcohols to 1,3-diols in high yield and with retention of stereochemistry at the propargylic position. The method is also amenable to propargylic amine derivatives, thereby establishing a route to enantioenriched 1,3-amino alcohol products. We also report the development of formal anti-Markovnikov reductive amination and oxidative hydration reactions to access linear amines and carboxylic acids, respectively, from terminal alkynes. This chemistry expands the scope of products that can be prepared from terminal alkynes by practical and high-yielding metal-catalyzed methods.

  13. The LOFT wide field monitor

    NASA Astrophysics Data System (ADS)

    Brandt, S.; Hernanz, M.; Alvarez, L.; Azzarello, P.; Barret, D.; Bozzo, E.; Budtz-Jørgensen, C.; Campana, R.; del Monte, E.; Donnarumma, I.; Evangalista, Y.; Feroci, M.; Galvez Sanchez, J. L.; Götz, D.; Hansen, F.; den Herder, J. W.; Hudec, R.; Huovelin, J.; Karelin, D.; Korpela, S.; Lund, N.; Orleanski, P.; Pohl, M.; Rashevski, A.; Santangelo, A.; Schanne, S.; Schmid, C.; Suchy, S.; Tenzer, C.; Vacchi, A.; Wilms, J.; Zampa, G.; Zampa, N.; in't Zand, J.; Zdziarski, A.

    2012-09-01

    LOFT (Large Observatory For x-ray Timing) is one of the four missions selected in 2011 for assessment study for the ESA M3 mission in the Cosmic Vision program, expected to be launched in 2024. The LOFT mission will carry two instruments with their prime sensitivity in the 2-30 keV range: a 10 m2 class large area detector (LAD) with a <1° collimated field of view and a wide field monitor (WFM) instrument based on the coded mask principle, providing coverage of more than 1/3 of the sky. The LAD will provide an effective area ~20 times larger than any previous mission and will by timing studies be able to address fundamental questions about strong gravity in the vicinity of black holes and the equation of state of nuclear matter in neutron stars. The prime goal of the WFM will be to detect transient sources to be observed by the LAD. However, with its wide field of view and good energy resolution of <300 eV, the WFM will be an excellent monitoring instrument to study long term variability of many classes of X-ray sources. The sensitivity of the WFM will be 2.1 mCrab in a one day observation, and 270 mCrab in 3s in observations of in the crowded field of the Galactic Center. The high duty cycle of the instrument will make it an ideal detector of fast transient phenomena, like X-ray bursters, soft gamma repeaters, terrestrial gamma flashes, and not least provide unique capabilities in the study of gamma ray bursts. A dedicated burst alert system will enable the distribution to the community of ~100 gamma ray burst positions per year with a ~1 arcmin location accuracy within 30 s of the burst. This paper provides an overview of the design, configuration, and capabilities of the LOFT WFM instrument.

  14. Multi-modular engineering of 1,3-propanediol biosynthesis system in Klebsiella pneumoniae from co-substrate.

    PubMed

    Wang, Meng; Wang, Guoqing; Zhang, Ting; Fan, Lihai; Tan, Tianwei

    2017-01-01

    1,3-Propanediol (1,3-PDO) is a monomer for the synthesis of various polyesters. It is widely used in industries including cosmetics, solvents, and lubricants. Here, the multi-modular engineering was used to improve the concentration and tolerance of 1,3-PDO in Klebsiella pneumoniae. Firstly, the concentration of 1,3-PDO was increased by 25 %, while the concentrations of by-products were reduced considerably through one-step evolution which focused on the glycerol pathway. In addition, the 1,3-PDO tolerance was improved to 150 g L(-1). Secondly, co-substrate transport system was regulated, and the 1,3-PDO concentration, yield, and productivity of the mutant were improved to 76.4 g L(-1), 0.53 mol mol(-1), and 2.55 g L(-1) h(-1), respectively. Finally, NADH regeneration was introduced and the recombinant strain was successfully achieved with a high productivity of 2.69 g L(-1) h(-1). The concentration and yield of 1,3-PDO were also improved to 86 g L(-1) and 0.59 mol mol(-1). This strategy described here provides an approach of achieving a superior strain which is able to produce 1,3-PDO with high productivity and yield.

  15. Problem Definition Study on 1,3-Dinitrobenzene, 1,3,5-Trinitrobenzene and Di-n-Propyl Adipate

    DTIC Science & Technology

    1979-11-01

    velocity in rats were studied by Pankow et ai. (1974) and Pankow et aZ. (1975). Male outbred albino rats, about 70 days old and weighing approximately...investigated the toxicity of 1,3,5- trinitrobenzene to rats. For the study, male albino rats, weighing between 100 and 170 grams, received 5% w/v 1,3,5...nitroaromatic compounds ’ teas ted, t*h..s, -,d iic a rir tha ,, -initro’enzene was i--ore readily reduced than other nitroaromatic compounds. Chambers

  16. Exact diagonalization study of ν = 1 / 3 + 1 / 3 bilayer quantum Hall in search of Fibonnacci anyons

    NASA Astrophysics Data System (ADS)

    Kim, Eun-Ah; Vaezi, Abolhassan; Lee, Kyungmin

    2015-03-01

    Non-abelian states with Fibonnacci anyons that can support universal topological quantum computation have been elusive. Recently it has been proposed that a remarkably simple setting of Abelian quantum Hall bilayer could support an exotic state with Fibonnacci anyons (Vaezi and Barkeshli, arXiv:1403.3383). Here we explore ν = 1 / 3 + 1 / 3 bilayer quantum Hall system considering different possibilities for interaction between bilayers using exact diagonalization. We find a sizable region in phase space potentially exhibiting topological degeneracy expected of Fibonnacci anyon states. This work has been supported by NSF CAREER with Grant Number DMR-0955822.

  17. Measurement of the vertical gradient of the semidiurnal tidal wind phase in winter at the 95 km level

    NASA Astrophysics Data System (ADS)

    Schminder, R.; Kurschner, D.

    1984-05-01

    When supplemented by absolute reflection height measurements, low frequency wind measurements in the 90-100 km height range become truly competitive in comparison with the more widely used radar meteor wind observations. For example, height profiles of the wind parameters in the so-called meteor zone can be obtained due to the considerable interdiurnal variability of the average nighttime reflection heights controlled by geomagnetic activity. The phase of the semidiurnal tidal wind is particularly height-dependent. The measured vertical gradient of 1/4 h/km in winter corresponds to a vertical wavelength of about 50 km. Wind measurements in the upper atmosphere, at heights between 90 and 100 km, were carried out at the Collm Geophysical Observatory of Karl Marx University Leipzig for a number of years. These measurements use the closely-spaced receiver method and three measuring paths, on 179, 227, and 272 kHz. They take place every day between sunset and sunrise, i.e., nightly. A night in this sense may last as long as 18 hours in winter. Both the measurements and their evaluation are completely automatic, and the prevailing winds and tides are separated.

  18. Measurement of the Vertical Gradient of the Semidiurnal Tidal Wind Phase in Winter at the 95 Km Level

    NASA Technical Reports Server (NTRS)

    Schminder, R.; Kurschner, D.

    1984-01-01

    When supplemented by absolute reflection height measurements, low frequency wind measurements in the 90-100 km height range become truly competitive in comparison with the more widely used radar meteor wind observations. For example, height profiles of the wind parameters in the so-called meteor zone can be obtained due to the considerable interdiurnal variability of the average nighttime reflection heights controlled by geomagnetic activity. The phase of the semidiurnal tidal wind is particularly height-dependent. The measured vertical gradient of 1/4 h/km in winter corresponds to a vertical wavelength of about 50 km. Wind measurements in the upper atmosphere, at heights between 90 and 100 km, were carried out at the Collm Geophysical Observatory of Karl Marx University Leipzig for a number of years. These measurements use the closely-spaced receiver method and three measuring paths, on 179, 227, and 272 kHz. They take place every day between sunset and sunrise, i.e., nightly. A night in this sense may last as long as 18 hours in winter. Both the measurements and their evaluation are completely automatic, and the prevailing winds and tides are separated.

  19. Do some deep-sea, sediment-dwelling species of harpacticoid copepods have 1000-km-scale range sizes?

    PubMed

    Easton, E E; Thistle, D

    2016-09-01

    The range sizes of sediment-dwelling deep-sea species are largely unknown. Such knowledge is important because a deep sea composed in large part of species with 100-km-scale ranges would be very different from one composed predominantly of species with 1000-km-scale ranges. For example, the total species richness would be much greater in the first case than in the second. As a step towards the determination of the distribution of species' range sizes in the deep sea, we asked whether harpacticoid copepods (Crustacea) on the continental rise in the northeastern Pacific had 1000-km-scale range sizes. We chose harpacticoids because they occur widely in deep-sea sediments and thus are a typical deep-sea taxon. In addition, they have no pelagic stage in their life history, so they allow a conservative test of hypotheses about species' range sizes. We used morphology and gene-sequence data to assign individuals to species. At least 13.3% of the species we studied had 1000-km-scale ranges, raising the question of how these species maintain genetic continuity.

  20. Genome Wide Association Studies

    NASA Astrophysics Data System (ADS)

    Sebastiani, Paola; Solovieff, Nadia

    The availability of high throughput technology for parallel genotyping has opened the field of genetics to genome-wide association studies (GWAS). These studies generate massive amount of genetic data that challenge investigators with issues related to data management, statistical analysis of large data sets, visualization, and annotation of results. We will review the common approach to analysis of GWAS data and then discuss options to learn more from these data.

  1. 1,3-Dien-5-ynes: Versatile Building Blocks for the Synthesis of Carbo- and Heterocycles.

    PubMed

    Aguilar, Enrique; Sanz, Roberto; Fernández-Rodríguez, Manuel A; García-García, Patricia

    2016-07-27

    1,3-Dien-5-ynes have been extensively used as starting materials for the synthesis of a wide number of different carbo- and heterocycles. The aim of this review is to give an overview of their utility in organic synthesis, highlighting the variety of compounds that can be directly accessed from single reactions over these systems. Thus, cycloaromatization processes are initially commented, followed by reactions directed toward the syntheses of five-membered rings, other carbocycles and, finally, heterocycles. The diverse methodologies that have been developed for the synthesis of each of these types of compounds from 1,3-dien-5-ynes are presented, emphasizing the influence of the reaction conditions and the use of additional reagents in the outcome of the transformations.

  2. Percent utilization of VO2 max at 5-km competition velocity does not determine time performance at 5 km among elite distance runners.

    PubMed

    Støa, Eva Maria; Støren, Øyvind; Enoksen, Eystein; Ingjer, Frank

    2010-05-01

    The present study investigated to what extent maximum oxygen uptake (VO2 max) and fractional utilization (%VO2 max) in 5-km competition speed correlate with 5-km performance times among elite long distance runners. Eight elite long distance runners with 5-km performance times of 15.10 minutes ( +/- 32 seconds) were tested for VO2 max during an incremental protocol and for %VO2 max during an 8-minute treadmill test at the velocity representing their 5-km seasonal best performance time. There was no correlation between fractional utilization and 5-km performance. The study showed no significant difference between VO2 max obtained during an incremental VO2 max test and %VO2 max when running for 8 minutes at the runner's individual 5-km competition speed. The 5-km time was related to the runner's VO2 max even in a homogenous high-level performance group. In conclusion, the present study found no relationship between fractional utilization and 5-km performance time. Training aiming to increase %VO2 max may thus be of little or no importance in performance enhancement for competitions lasting up to approximately 20 minutes.

  3. The Central Logic Board for the KM3NeT detector: Design and production

    NASA Astrophysics Data System (ADS)

    Musico, P.

    2016-07-01

    The KM3NeT deep sea neutrino observatory will include a very large number of multi-Photomultiplier (PMT) optical modules (DOM) to detect the Cherenkov light generated by secondary particles produced in neutrino interactions. The Central Logic Board (CLB) has been developed to acquire timing and amplitude information from the PMT signals, implementing time-to-digital conversion (TDC) with time over threshold (TOT) technique. The board is also used to configure all the DOM subsystems, to assist in the DOM position and orientation, calibration and to monitor temperature and humidity in the DOM itself. All the collected data are transmitted to shore using a wide-bandwidth optical network. Moreover, through the optical network, all the DOMs are kept synchronized in time within 1 ns precision using the White Rabbit (WR) Precision Time Protocol (PTP) over an Ethernet connection. A large Field Programmable Gate Array (FPGA) has been adopted to implement all the specifications witht the requested performances. The CLB will be also used in the base container of the detection unit (DU) to set-up and monitor all the requested functionalities: in this scenario a dedicated firmware and software will be deployed on board. The design has been started in early 2013 and several prototypes have been developed. After deep test carried on in different EU laboratories, the final mass production batch of 600 boards has been ordered and built: all the CLB are now ready for integration in the DOMs and base containers. The first two KM3NeT DU will be deployed in summer 2015 and all other units are in advanced stage of integration.

  4. Purification and Characterization of an Endo-(1,3)-β-d-Glucanase from Trichoderma longibrachiatum

    PubMed Central

    Tangarone, B.; Royer, J. C.; Nakas, J. P.

    1989-01-01

    A laminarinase [endo-(1,3)-β-d-glucanase] has been purified from Trichoderma longibrachiatum cultivated with d-glucose as the growth substrate. The enzyme was found to hydrolyze laminarin to oligosaccharides varying in size from glucose to pentaose and to lesser amounts of larger oligosaccharides. The enzyme was unable to cleave laminaribiose but hydrolyzed triose to laminaribiose and glucose. The enzyme cleaved laminaritetraose, yielding laminaritriose, laminaribiose, and glucose, and similarly cleaved laminaripentaose, yielding laminaritetraose, laminaritriose, laminaribiose, and glucose. The enzyme cleaved only glucans containing β-1,3 linkages. The pH and temperature optima were 4.8 and 55°C, respectively. Stability in the absence of a substrate was observed at temperatures up to 50°C and at pH values between 4.9 and 9.3. The molecular mass was determined to be 70 kilodaltons by sodium dodecyl sulfate-12.5% polyacrylamide gel electrophoresis, and the pI was 7.2. Enzyme activity was significantly inhibited in the presence of HgCl2, MnCl2, KMnO4, and N-bromosuccinimide. The Km of the enzyme on laminarin was 0.0016%, and the Vmax on laminarin was 3,170 μmol of glucose equivalents per mg of the pure enzyme per min. Images PMID:16347821

  5. VLA observations of Uranus at 1. 3-20 cm

    SciTech Connect

    De Pater, I.; Gulkis, S.

    1988-08-01

    Observations of Uranus, obtained with resolution 0.5-1.2 arcsec at wavelengths 1.3, 2, 6, and 20 cm using the A and B configurations of the VLA in June-July 1982, October 1983, and February 1984, are reported. The disk-averaged brightness temperatures (DABTs) are determined by model fitting, and the results are presented in extensive graphs and contour maps and characterized in detail. Findings discussed include: (1) an overall spectrum which is relatively flat above 6 cm, (2) 1.3-6-cm brightness which is concentrated nearer to the pole than to the subsolar point, and (3) small changes in DABT from 1982 to 1983/1984 (consistent with an explanation based on a pole-equator temperature gradient). 16 references.

  6. [1,3-Bis(diphenylphosphino)propane]trichlorooxorhenium(V).

    PubMed

    Suescun, L; Mombrú, A W; Mariezcurrena, R A; Pardo, H; Russi, S; Kremer, C; Rivero, M; Kremer, E

    2000-08-01

    Trichlorooxo[1,3-propanediylbis(diphenylphosphine)-P,P ']rhenium(V), [ReCl(3)O(C(27)H(26)P(2))], crystallizes with four formula units per unit cell. The crystal structure consists of neutral complexes of [ReOCl(3)(dppp)] [dppp is 1,3-bis(diphenylphosphino)propane] packed by H.pi-ring interactions. The Re atom is octahedrally coordinated to the oxo anion, three Cl atoms and two P atoms from the dppp ligand. The six-membered ring formed by the bidentate dppp ligand and the rhenium metal centre is in a chair conformation. The title compound is an intermediate in the synthesis of bis(dppp) complexes of rhenium.

  7. Wide Angle Movie

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This brief movie illustrates the passage of the Moon through the Saturn-bound Cassini spacecraft's wide-angle camera field of view as the spacecraft passed by the Moon on the way to its closest approach with Earth on August 17, 1999. From beginning to end of the sequence, 25 wide-angle images (with a spatial image scale of about 14 miles per pixel (about 23 kilometers)were taken over the course of 7 and 1/2 minutes through a series of narrow and broadband spectral filters and polarizers, ranging from the violet to the near-infrared regions of the spectrum, to calibrate the spectral response of the wide-angle camera. The exposure times range from 5 milliseconds to 1.5 seconds. Two of the exposures were smeared and have been discarded and replaced with nearby images to make a smooth movie sequence. All images were scaled so that the brightness of Crisium basin, the dark circular region in the upper right, is approximately the same in every image. The imaging data were processed and released by the Cassini Imaging Central Laboratory for Operations (CICLOPS)at the University of Arizona's Lunar and Planetary Laboratory, Tucson, AZ.

    Photo Credit: NASA/JPL/Cassini Imaging Team/University of Arizona

    Cassini, launched in 1997, is a joint mission of NASA, the European Space Agency and Italian Space Agency. The mission is managed by NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Office of Space Science, Washington DC. JPL is a division of the California Institute of Technology, Pasadena, CA.

  8. Equatorial ionosphere observations from ionosonde satellite at an altitude of 350 km

    NASA Astrophysics Data System (ADS)

    Kotonaeva, Nadezhda; Danilkin, Nick

    Experimental study of the ionosphere from a MIR MAN SPACE STATUON (MMSS) was held in 1999. The new and interesting information was obtained in the study of the equatorial ionosphere. Critical frequencies and plasma frequencies distributions along the orbit at an altitude of MMSS had the appearance of two distinct peaks (crests) on both sides of the geomagnetic equator during the afternoon and evening local time. This corresponds to a typical daily distribution of plasma frequencies in areas of the equatorial anomaly (EA). The values of the critical frequency on the tops of EA "crest" exceeded the upper limit (16 MHz) of the ionosonde frequency often. In many cases, the measured values significantly exceeded the forecast model IRI. Analysis of the daytime values of the critical frequency on the tops of EA "crests" showed their approximate equality in the peaks of the southern and northern "crests". General analysis of the location of EA "crests" vertices during a night local time in the 1999 spring showed that the coordinates of the "crest" maxima are consistent with the finding of the geomagnetic equator, which corresponds to the theoretical predictions of the model provisions and IRI. MMSS was often lower than the height of the ionosphere maximum near the EA existence. At that time, satellite ionograms were recorded with previously unknown continuous trace of a characteristic shape with large group delay. This group delay is increasing monotonically with frequency increase. The trace was called "retardation of the lower trace" (RLT). The reason for it appearance is the oblique propagation of radio waves in a wide frequency range with the return to the satellite. A special kind of trajectory can be explained by large gradients of the electron density in a region of signal propagation. Gradients of plasma frequencies at the MMSS heights causing RLT were evaluated by a method of a trajectory synthesis. In the daytime they do not exceed 1 MHz / 100km. In the evening

  9. Dendrimers Based on [1,3,5]-Triazines

    PubMed Central

    STEFFENSEN, MACKAY B.; HOLLINK, EMILY; KUSCHEL, FRANK; BAUER, MONIKA; SIMANEK, ERIC E.

    2009-01-01

    A comprehensive and chronological account of dendrimers based on [1,3,5]-triazines is provided. Synthetic strategies to install the triazine through cycloaddition, cyclotrimerization, and nucleophilic aromatic substitution of cyanuric chloride are discussed. Motivations and applications of these architectures are surveyed, including the preparation of supra-molecular assemblies in the solution and solid states and their use in medicines, advanced materials, and separations when anchored to solid supports. PMID:19953202

  10. 1,3,6,8-Tetranitrocarbazole (TNC) Synthesis and Optimization

    DTIC Science & Technology

    2013-03-01

    Specification MIL-T-13 11 Distribution List 25 FIGURES 1 Carbazole added to sulphuric acid , heated till carbazole becomes sulfonated 1 2 Three-stage...1,3,6,8-TETRANITROCABAZOLE The TNC has traditionally been synthesized with a mixed acid system of sulphuric acid and nitric acid . The carbazole...is added to the sulphuric acid and heated until the carbazole becomes fully sulfonated (fig. 1). Then nitric acid is added to the mixture and

  11. Regiodivergent and Stereoselective Hydrosilylation of 1,3-Disubstituted Allenes.

    PubMed

    Miller, Zachary D; Dorel, Ruth; Montgomery, John

    2015-07-27

    Methods for the highly stereoselective and regiodivergent hydrosilylation of 1,3-disubstituted allenes have been developed. The synthesis of E allylsilanes is accomplished with palladium NHC catalysts, and trisubstituted Z alkenylsilanes are accessed with nickel NHC catalysts. Unsymmetrically substituted allenes are well tolerated with nickel catalysis and afford Z alkenylsilanes. Evidence for a plausible mechanism was obtained through an isotopic double-labeling crossover study.

  12. 21 CFR 573.225 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... specifications in § 173.220(a) of this chapter. (b) It is intended for use in swine feed as a source of energy. (c) It is to be thoroughly mixed into feed at levels not to exceed 9 percent of the dry matter of the total ration. (d) 1,3-Butylene glycol should be mixed in feed with equipment adapted for the addition...

  13. 21 CFR 573.225 - 1,3-Butylene glycol.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... specifications in § 173.220(a) of this chapter. (b) It is intended for use in swine feed as a source of energy. (c) It is to be thoroughly mixed into feed at levels not to exceed 9 percent of the dry matter of the total ration. (d) 1,3-Butylene glycol should be mixed in feed with equipment adapted for the addition...

  14. Complete genome sequence of Coriobacteriaceae Strain 68-1-3, a novel mucus- degrading isolate from the swine intestinal tract

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A novel Coriobacteriaceae bacterium (Strain 68-1-3) was isolated from the ileum of the swine intestinal tract using a selective mucus-based medium. Here we present the finished genome sequence for the swine commensal, totaling 1.97 Mb in size. Genome-wide differences and low 16S rRNA gene sequence ...

  15. Recent Advances in Boron-Substituted 1,3-Dienes Chemistry: Synthesis and Application.

    PubMed

    Pyziak, Jadwiga; Walkowiak, Jędrzej; Marciniec, Bogdan

    2017-03-13

    In the syntheses developed to access naturally occurring compounds, especially bioactive substances, boron-functionalized dienes (also "linchpin" reagents) are used as key reagents. Structurally unique dienes are found in nature, and play important biological and chemical roles. Recently, linchpin moieties have been proved as useful substrates for a variety of highly functionalized chemical transformations. The products of these processes are potentially of some use for the syntheses of an important class of natural products showing a wide range of biological activities. This review describes progress in the synthesis of borylsubstituted buta-1,3-dienes as well as their application in organic chemistry.

  16. Developing Knowledge Management (KM): Contributions by Organizational Learning and Total Quality Management (TQM)

    ERIC Educational Resources Information Center

    Hung, Richard Yu-Yuan; Lien, Bella Ya-Hui

    2005-01-01

    Knowledge management is an integral business function for many organizations to manage intellectual resources effectively. From a resource-based perspective, organizational learning and TQM are antecedents that are closely related to KM. The purposes of this study were to explain the contents of KM, and explore the relationship between KM-related…

  17. Biodegradation of the nitramine explosives hexahydro-1,3,5-trinitro-1,3,5-triazine and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine in cold marine sediment under anaerobic and oligotrophic conditions.

    PubMed

    Zhao, Jian-Shen; Greer, Charles W; Thiboutot, Sonia; Ampleman, Guy; Hawari, Jalal

    2004-02-01

    The in situ degradation of the two nitramine explosives, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), was evaluated using a mixture of RDX and HMX, incubated anaerobically at 10 degrees C with marine sediment from a previous military dumping site of unexploded ordnance (UXO) in Halifax Harbor, Nova Scotia, Canada. The RDX concentration (14.7 mg.L-1) in the aqueous phase was reduced by half in 4 days, while reduction of HMX concentration (1.2 mg.L-1) by half required 50 days. Supplementation with the carbon sources glucose, acetate, or citrate did not affect the removal rate of RDX but improved removal of HMX. Optimal mineralization of RDX and HMX was obtained in the presence of glucose. Using universally labeled (UL)-[14C]RDX, we obtained a carbon mass balance distributed as follows: CO2, 48%-58%; water soluble products, 27%-31%; acetonitrile extractable products, 2.0%-3.4%; and products covalently bound to the sediments and biomass, 8.9% (in the presence of glucose). The disappearance of RDX was accompanied by the formation of the mononitroso derivative hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and formaldehyde (HCHO) that subsequently disappeared. In the case of HMX, mineralization reached only 13%-27% after 115 days of incubation in the presence or absence of the carbon sources. The disappearance of HMX was also accompanied by the formation of the mononitroso derivative. The total population of psychrotrophic anaerobes that grew at 10 degrees C was 2.6 x 10(3) colony-forming units.(g sediment dry mass)-1, and some psychrotrophic sediment isolates were capable of degrading RDX under conditions similar to those used for sediments. Based on the distribution of products, we suggest that the sediment microorganisms degrade RDX and HMX via an initial reduction to the corresponding mononitroso derivative, followed by denitration and ring cleavage.

  18. Construction of stress-induced metabolic pathway from glucose to 1,3-propanediol in Escherichia coli.

    PubMed

    Liang, Quanfeng; Zhang, Haojun; Li, Shengnan; Qi, Qingsheng

    2011-01-01

    1,3-Propanediol is an important chemical widely used in polymer production, but its availability is being restricted owing to its expensive synthesis. The aim of this study was to engineer an Escherichia coli strain that can produce 1,3-propanediol directly from glucose. We successfully constructed a stress-induced metabolic pathway from glucose to 1,3-propanediol in recombinant E. coli by the expression of gpd1 and gpp2 genes from Saccharomyces cerevisiae and dha operon from Klebsiella pneumoniae, respectively. Batch cultivation of the recombinant E. coli showed that 12.1 g/L 1,3-propanediol was accumulated in the culture without using any inducer.

  19. Survival of the Tardigrade Hypsibius Dujardini during Hypervelocity Impact Events up to 5.49 km s-1

    NASA Astrophysics Data System (ADS)

    Pasini, D.

    2014-04-01

    Studies have previously been conducted to verify the survivability of living cells during hypervelocity impact events to test the panspermia and lithopanspermia hypotheses [1, 2]. It has been demonstrated that bacteria survive impacts up to 5.4 km s-1 (approx. shock pressure 30 GPa) - albeit with a low probability of survival [1], whilst larger, more complex, objects (such as seeds) break up at ~1 km s-1 [2]. The survivability of yeast spores in impacts up to 7.4 km s-1 has also recently been shown [3]. Previous work by the authors demonstrated the survivability of Nannochloropsis Oculata Phytoplankton, a eukaryotic photosynthesizing autotroph found in the 'euphotic zone' (sunlit surface layers of oceans [4]), at impact velocities up to 6.07 km s-1 [5]. Other groups have also reported that lichens are able to survive shocks in similar pressure ranges [6]. However, whilst many simple single celled organisms have now been shown to survive such impacts (and the associated pressures) as those encountered during the migration of material from one planet to another [1, 3, 5], complex multicellular organisms have either largely not been tested or, those that have been, have not survived the process [2]. Hypsibius dujardini, like most species of tardigrade, are complex organisms composed of approximately 40,000 cells [7]. When humidity decreases they enter a highly dehydrated state known as a 'tun' and can survive extreme temperatures (as low as - 253°C or as high as 151°C), as well as exposure to Xrays and the vacuum of space [7]. Here we test the shock survivability of Hypsibius dujardini by firing a nylon projectile onto a frozen sample of water containing frozen tardigrades using a light gas gun (LGG) [8]. The recovered ice and water were then analysed under an optical microscope to check the viability of any remnant organisms that may have survived impact, and the pressures generated.

  20. Determination of 2-isovaleryl-1,3-indandione with 2, 4-dinitro-phenylhydrazine

    USGS Publications Warehouse

    Menzie, C.M.; Adomaitis, V.A.; Reichel, W.L.

    1962-01-01

    At present, three 2-alkyl-1,3-indandiones (PMP, pival, and diphacinon) are widely used as rodenticides. Because analytical procedures now in use are empirical and do not furnish adequate or positive means for distinguishing among these closely related compounds, studies were undertaken to develop a sensitive and specific method for the determination of PMP. The relation between KCN and the 2,4-dinitrophenylhydrazone of PMP was investigated and shown to be sensitive and specific. A deeply colored solution is produced with an absorption maximum at 540 mu. This solution obeys Beer?s law over a wide range. The molar absorptivity for the developed color was calculated to be 3.0 X 104. This reaction can be used also as a spot test to detect as little as 1 ug. of PMP.

  1. Chemical properties of 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane-methyl methacrylate copolymer.

    PubMed

    Aoyagi, Yujin; Umemoto, Kozo; Kurata, Shigeaki

    2012-01-01

    This study evaluated the chemical properties such as water sorption, water solubility and solvent resistance of a new resin material consisting of 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane (BMPMS) and methyl methacrylate (MMA). Water sorption was evaluated by immersing the specimens in water at 37±1°C for 1 week, water solubility was evaluated by keeping the specimens in a desiccator under dry conditions at 37±1°C until the weight became constant, and solvent resistance was evaluated by immersing the specimens in acetone for 1 week and measuring the dissolved weight of acetone volatilized from those liquids. The water sorption and solvent resistance of the new resin were improved with increasing amount of BMPMS, whereas the water solubility remained the same value and did not depend on the amount of BMPMS.

  2. The longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX)

    PubMed Central

    Spitzer, Denis

    2017-01-01

    Research efforts for realizing safer and higher performance energetic materials are continuing unabated all over the globe. While the thermites – pyrotechnic compositions of an oxide and a metal – have been finely tailored thanks to progress in other sectors, organic high explosives are still stagnating. The most symptomatic example is the longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX). Recent advances in crystallization processes and milling technology mark the beginning of a new area which will hopefully lead the pyroelectric industry to finally embrace nanotechnology. This work reviews the previous and current techniques used to crystallize RDX at a submicrometer scale or smaller. Several key points are highlighted then discussed, such as the smallest particle size and its morphology, and the scale-up capacity and the versatility of the process. PMID:28326236

  3. Underwater acoustic positioning system for the SMO and KM3NeT - Italia projects

    SciTech Connect

    Viola, S.; Barbagallo, G.; Cacopardo, G.; Calí, C.; Cocimano, R.; Coniglione, R.; Costa, M.; Cuttone, G.; D'Amato, C.; D'Amato, V.; D'Amico, A.; De Luca, V.; Del Tevere, F.; Distefano, C.; Ferrera, F.; Gmerk, A.; Grasso, R.; Imbesi, M.; Larosa, G.; Lattuada, D.; and others

    2014-11-18

    In the underwater neutrino telescopes, the positions of the Cherenkov light sensors and their movements must be known with an accuracy of few tens of centimetres. In this work, the activities of the SMO and KM3NeT-Italia teams for the development of an acoustic positioning system for KM3NeT-Italia project are presented. The KM3NeT-Italia project foresees the construction, within two years, of 8 towers in the view of the several km{sup 3}-scale neutrino telescope KM3NeT.

  4. Wide Band Artificial Pulsar

    NASA Astrophysics Data System (ADS)

    Parsons, Zackary

    2017-01-01

    The Wide Band Artificial Pulsar (WBAP) is an instrument verification device designed and built by the National Radio Astronomy Observatory (NRAO) in Green Bank, West Virgina. The site currently operates the Green Bank Ultimate Pulsar Processing Instrument (GUPPI) and the Versatile Green Bank Astronomical Spectrometer (VEGAS) digital backends for their radio telescopes. The commissioning and continued support for these sophisticated backends has demonstrated a need for a device capable of producing an accurate artificial pulsar signal. The WBAP is designed to provide a very close approximation to an actual pulsar signal. This presentation is intended to provide an overview of the current hardware and software implementations and to also share the current results from testing using the WBAP.

  5. Solid Waste Projection Model: Database (Version 1. 3)

    SciTech Connect

    Blackburn, C.L.

    1991-11-01

    The Solid Waste Projection Model (SWPM) system is an analytical tool developed by Pacific Northwest Laboratory (PNL) for Westinghouse Hanford Company (WHC). The SWPM system provides a modeling and analysis environment that supports decisions in the process of evaluating various solid waste management alternatives. This document, one of a series describing the SWPM system, contains detailed information regarding the software and data structures utilized in developing the SWPM Version 1.3 Database. This document is intended for use by experienced database specialists and supports database maintenance, utility development, and database enhancement.

  6. Syndrome measurement order for the [[7,1,3

    NASA Astrophysics Data System (ADS)

    Weinstein, Yaakov S.

    2016-03-01

    In this work, we explore the accuracy of quantum error correction depending of the order of the implemented syndrome measurements. CSS codes require that bit-flip and phase-flip syndromes be measured separately. To comply with fault-tolerant demands and to maximize accuracy, this set of syndrome measurements should be repeated allowing for flexibility in the order of their implementation. We examine different possible orders of Shor-state and Steane-state syndrome measurements for the [[7,1,3

  7. Cobalt-Catalysed Asymmetric Hydrovinylation of 1,3-Dienes

    PubMed Central

    Timsina, Yam N.; Sharma, Rakesh K.

    2015-01-01

    In the presence of bidentate 1,n-bis-diphenylphosphinoalkane-CoCl2 complexes {Cl2Co[P~P]} and Me3Al or methylaluminoxane, acyclic (E)-1,3-dienes react with ethylene (1 atmosphere) to give excellent yields of hydrovinylation products. The regioselectivity (1,4- or 1,2-addition) and the alkene configuration (E- or Z-) of the resulting product depend on the nature of the ligand and temperature at which the reaction is carried out. Cobalt(II)-complexes of 1,1-diphenylphosphinomethane and similar ligands with narrow bite angles give mostly 1,2-addition, retaining the E-geometry of the original diene. Complexes of most other ligands at low temperature (−40 °C) give almost exclusively a single branched product, (Z)-3-alkylhexa-1,4-diene, which arises from a 1,4-hydrovinylation reaction. A minor product is the linear adduct, a 5-alkyl-hexa-1,4-diene, also arising from a 1,4-addition of ethylene. As the temperature is increased, a higher proportion of the major 1,4-adduct appears as the (E)-isomer. The unexpectedly high selectivity seen in the Co-catalysed reaction as compared to the corresponding Ni-catalysed reaction can be rationalized by invoking the intermediacy of an η4-[(diene)[P~P]CoH]+-complex and its subsequent reactions. The enhanced reactivity of terminal E-1,3-dienes over the corresponding Z-dienes can also be explained on the basis of the ease of formation of this η4-complex in the former case. The lack of reactivity of the X2Co(dppb) (X = Cl, Br) complexes in the presence of Zn/ZnI2 makes the Me3Al-mediated reaction different from the previously reported hydroalkenylation of dienes. Electron-rich phospholanes, bis-oxazolines and N-heterocyclic carbenes appear to be poor ligands for the Co(II)-catalysed hydrovinylation of 1,3-dienes. An extensive survey of chiral ligands reveals that complexes of DIOP, BDDP and Josiphos ligands are quite effective for these reactions even at −45 °C and enantioselectivities in the range of 90–99 % ee can be realized

  8. The Crust and Mantle Relationships Beneath Central and Southern Iberian Peninsula constrained by a 550 km long multiseismic transect

    NASA Astrophysics Data System (ADS)

    Ehsan, Siddique Akhtar; Carbonell, Ramon; Simancas, Jose Fernando; Martinez Poyatos, David; Azor, Antonio; Ayarza, Puy; Storti, Fabrizio

    2013-04-01

    A composite lithospheric cross section which is composed by data from controlled source multiseismic experiments strongly constrains the lithospheric structure of southwestern Iberia. The data includes coincident normal incidence and wide-angle profiles along an, approximately, 550 km long transect. This transect goes across, from North-to-South, the major tectonic zones that build up Southwestern part of the Iberian Peninsula (the Central Iberian Zone -CIZ-, the Ossa-Morena Zone -OMZ- and the South Portuguese Zone -SPZ-). The knowledge provided by these datasets constitutes the base to develop multidisciplinary models of the lithosphere. The multichannel deep seismic high resolution (60-90 fold) profiles, IBERSEIS & ALCUDIA were acquired in summer 2001 and 2007 are about 300 and 250 km long respectively. The transects image 20 s (TWTT), about 70 km depth. To address the crust and upper mantle structural relationships a reassessment of the normal incidence seismic reflection transect ALCUDIA has been carried out. We revised the key processing steps and applied advance analysis on the ALCUDIA transect with the aim to improve the signal to noise ratio especially in the deep parts and to produce a depth migrated image. The velocity model generated through wide-angle seismic survey (2003) was used to convert IBERSEIS time migrated stack image into depth. The new data processing flow provide better structural constraints on the shallow and deep structures as the current images reveal indentation features which strongly suggest horizontal tectonics. The ALCUDIA transect shows slightly less reflective upper crust about 13 km thick decoupled from the comparatively reflective lower crust. The reflectivity of the lower crust is continuous, high amplitude, horizontal and parallel though evidences of deformation are present as flat-ramp-flat geometry on the northeastern portion and a "Crocodile structure" wedging into the upper mantle on the southwestern portion of the ALCUDIA

  9. The effect of music on 10-km cycle time-trial performance.

    PubMed

    Hagen, Jana; Foster, Carl; Rodríguez-Marroyo, Jose; de Koning, Jos J; Mikat, Richard P; Hendrix, Charles R; Porcari, John P

    2013-01-01

    Music is widely used as an ergogenic aid in sport, but there is little evidence of its effectiveness during closed-loop athletic events. In order to determine the effectiveness of music as an ergogenic aid, well-trained and task-habituated cyclists performed 10-km cycle time trials either while listening to self-selected motivational music or with auditory input blocked. There were no statistically significant differences in performance time or physiological or psychological markers related to music (time-trial duration17.75 ± 2.10 vs 17.81 ± 2.06 min, mean power output 222 ± 66 vs 220 ± 65 W, peak heart rate184 ± 9 vs 183 ± 8 beats/min, peak blood lactate12.1 ± 2.6 vs 11.9 ± 2.1 mmol/L, and final rating of perceived exertion 8.4 ± 1.5 vs 8.5 ± 1.6). It is concluded that during exercise at competitive intensity, there is no meaningful effect of music on either performance or physiology.

  10. Observations of earthquake source parameters at 2 km depth in the Long Valley Caldera, eastern California

    USGS Publications Warehouse

    Prejean, Stephanie G.; Ellsworth, William L.

    2001-01-01

    To investigate seismic source parameter scaling and seismic efficiency in the Long Valley caldera, California, we measured source parameters for 41 earthquakes (M 0.5 to M 5) recorded at 2 km depth in the Long Valley Exploratory Well. Borehole recordings provide a wide frequency bandwidth, typically 1 to 200–300 Hz, and greatly reduce seismic noise and path effects compared to surface recordings. We calculated source parameters in both the time and frequency domains for P and S waves. At frequencies above the corner frequency, spectra decay faster than ω3, indicating that attenuation plays an important role in shaping the spectra (path averaged Qp = 100–400, Qs = 200–800). Source parameters are corrected for attenuation and radiation pattern. Both static stress drops and apparent stresses range from approximately 0.01 to 30 MPa. Although static stress drops do not vary with seismic moment for these data, our analyses are consistent with apparent stress increasing with increasing moment. To estimate tectonic driving stress and seismic efficiencies in the region, we combined source parameter measurements with knowledge of the stress field and a Coulomb failure criterion to infer a driving stress of 40–70 MPa. Subsequent seismic efficiencies are consistent with McGarr's (1999) hypothesis of a maximum seismic efficiency of 6%.

  11. Long-range BOTDA sensor over 50 km distance employing pre-pumped Simplex coding

    NASA Astrophysics Data System (ADS)

    Sun, Qiao; Tu, Xiaobo; Sun, Shilin; Meng, Zhou

    2016-05-01

    We propose and demonstrate a long-range Brillouin optical time-domain analysis (BOTDA) sensor based on the pre-pumped Simplex coding technique. This approach combines Simplex coding with the pulse pre-pump technique, which takes full advantage of the signal-to-noise ratio enhancement provided by optical pulse coding and achieves meter-scale spatial resolution with an unbroadened Brillouin gain spectrum by the use of pre-pumped short pump pulse. Compared to the widely used differential pulse-width pair technique, a comparable performance can be realized while the measurement time is reduced by half. The theoretical analysis of pre-pumped Simplex coding applied to BOTDA systems is presented and a proof-of-concept experiment is carried out along a ∼51 km single-mode fiber composed of two fiber segments with slightly different Brillouin frequency shift values. With the proposed technique, Brillouin frequency shifts of the two different fiber sections at the end of the sensing fiber are clearly distinguished, and the obtained spatial resolution and temperature/strain accuracy along the sensing fiber are respectively 1 m and {0.4}\\circ {{C}}/8μ \\varepsilon . According to the experimental results, we believe that the BOTDA employing pre-pumped Simplex coding is able to realize extra-long distance sensing without Raman amplification, while keeping a high spatial resolution and measurement accuracy.

  12. Delayed myelosuppression with acute exposure to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and environmental degradation product hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) in rats

    SciTech Connect

    Jaligama, Sridhar; Kale, Vijay M.; Wilbanks, Mitchell S.; Perkins, Edward J.; Meyer, Sharon A.

    2013-02-01

    Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a widely used munitions compound, and hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), its N-nitroso product of anaerobic microbial nitroreduction, are contaminants of military sites. Previous studies have shown MNX to be the most acutely toxic among the nitroreduced degradation products of RDX and to cause mild anemia at high dose. The present study compares hematotoxicity with acute oral exposure to MNX with parent RDX. Both RDX and MNX caused a modest decrease in blood hemoglobin and ∼ 50% loss of granulocytes (NOAELs = 47 mg/kg) in female Sprague–Dawley rats observed 14 days post-exposure. We explored the possibility that blood cell loss observed after 14 days was delayed in onset because of toxicity to bone marrow (BM) progenitors. RDX and MNX decreased granulocyte/macrophage-colony forming cells (GM-CFCs) at 14, but not 7, days (NOAELs = 24 mg/kg). The earliest observed time at which MNX decreased GM-CFCs was 10 days post-exposure. RDX and MNX likewise decreased BM burst-forming units-erythroid (BFU-Es) at 14, but not 7, days. Granulocyte–erythrocyte–monocyte–megakaryocyte (GEMM)-CFCs were unaffected by RDX and MNX at 7 days suggesting precursor depletion did not account for GM-CFC and BFU-E loss. MNX added to the culture media was without effect on GM-CFC formation indicating no direct inhibition. Flow cytometry showed no differential loss of BM multilineage progenitors (Thy1.1{sup +}) or erythroid (CD71{sup +}) precursors with MNX suggesting myeloid and erythroid lineages were comparably affected. Collectively, these data indicate that acute exposure to both RDX and MNX caused delayed suppression of myelo- and erythropoiesis with subsequent decrease of peripheral granulocytes and erythrocytes. Highlights: ► Acute oral exposure to munitions RDX causes myelosuppression. ► Environmental degradation product MNX is comparable in effect. ► RDX and MNX are cytotoxic to both myeloid and erythroid

  13. Crustal nature and seismic structure of the geological provinces offshore the SW Iberia: Highlights of the NEAREST-SEIS wide-angle seismic survey

    NASA Astrophysics Data System (ADS)

    Martínez-Loriente, S.; Sallares, V.; Gailler, A.; Bartolome, R.; Gracia, E.; Gutscher, M.; Diaz, J.

    2011-12-01

    ending at easternmost SAP beyond the NW Moroccan margin. A total of 15 OBS and 7 land-stations were deployed along this profile. The inverted model shows three domains. The northern part is characterized by a ~30 km thick continental crust, corresponding to the continental Variscan basement. In the central part, there is a 60 km-wide transition zone, where the crust abruptly thins to ~20 km. On its southern half, we identified a ~4 km-thick pile of low velocity unconsolidated sediments, corresponding to the Upper Miocene Gulf of Cadiz sedimentary wedge, overlying a 1-3 km-thick section of Mesozoic to Eocene sediments, and a 7-8 km-thick old, oceanic crust. According to tectonic reconstructions, this band of oceanic crust should have been emplaced during the early phases of seafloor spreading between Iberia and Nubia plates (Jurassic age).

  14. Heats of NF(sub n) (n= 1-3) and NF(sub n)(+)(n = 1-3)

    NASA Technical Reports Server (NTRS)

    Ricca, Alessandra; Arnold, James (Technical Monitor)

    1998-01-01

    Accurate heats of formation are computed for NF(sub n) and NF(sub n)(+), for n = 1-3. The geometries and the vibrational frequencies are determined at the B3LYP level of theory. The energetics are determined at the CCSD(T) level of theory. Basis set limit values are obtained by extrapolation. In those cases where the CCSD(T) calculations become prohibitively large, the basis set extrapolation is performed at the MP2 level. The temperature dependence of the heat of formation, heat capacity, and entropy are computed for the temperature range 300 to 4000 K and fit to a polynomial.

  15. Computational prediction of probabilistic ignition threshold of pressed granular Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) under shock loading

    NASA Astrophysics Data System (ADS)

    Kim, Seokpum; Miller, Christopher; Horie, Yasuyuki; Molek, Christopher; Welle, Eric; Zhou, Min

    2016-09-01

    The probabilistic ignition thresholds of pressed granular Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine explosives with average grain sizes between 70 μm and 220 μm are computationally predicted. The prediction uses material microstructure and basic constituent properties and does not involve curve fitting with respect to or prior knowledge of the attributes being predicted. The specific thresholds predicted are James-type relations between the energy flux and energy fluence for given probabilities of ignition. Statistically similar microstructure sample sets are computationally generated and used based on the features of micrographs of materials used in actual experiments. The predicted thresholds are in general agreement with measurements from shock experiments in terms of trends. In particular, it is found that grain size significantly affects the ignition sensitivity of the materials, with smaller sizes leading to lower energy thresholds required for ignition. For example, 50% ignition threshold of the material with an average grain size of 220 μm is approximately 1.4-1.6 times that of the material with an average grain size of 70 μm in terms of energy fluence. The simulations account for the controlled loading of thin-flyer shock experiments with flyer velocities between 1.5 and 4.0 km/s, constituent elasto-viscoplasticity, fracture, post-fracture contact and friction along interfaces, bulk inelastic heating, interfacial frictional heating, and heat conduction. The constitutive behavior of the materials is described using a finite deformation elasto-viscoplastic formulation and the Birch-Murnaghan equation of state. The ignition thresholds are determined via an explicit analysis of the size and temperature states of hotspots in the materials and a hotspot-based ignition criterion. The overall ignition threshold analysis and the microstructure-level hotspot analysis also lead to the definition of a macroscopic ignition parameter (J) and a microscopic

  16. A 16-year time series of 1 km AVHRR satellite data of the conterminous United States and Alaska

    USGS Publications Warehouse

    Eidenshink, Jeff

    2006-01-01

    The U.S. Geological Survey (USGS) has developed a 16-year time series of vegetation condition information for the conterminous United States and Alaska using 1 km Advanced Very High Resolution Radiometer (AVHRR) data. The AVHRR data have been processed using consistent methods that account for radiometric variability due to calibration uncertainty, the effects of the atmosphere on surface radiometric measurements obtained from wide field-of-view observations, and the geometric registration accuracy. The conterminous United States and Alaska data sets have an atmospheric correction for water vapor, ozone, and Rayleigh scattering and include a cloud mask derived using the Clouds from AVHRR (CLAVR) algorithm. In comparison with other AVHRR time series data sets, the conterminous United States and Alaska data are processed using similar techniques. The primary difference is that the conterminous United States and Alaska data are at 1 km resolution, while others are at 8 km resolution. The time series consists of weekly and biweekly maximum normalized difference vegetation index (NDVI) composites.

  17. Sub-km HIMU-type Enriched Mantle at a Mid-ocean Ridge Far From a Plume: Endeavour, JdFR

    NASA Astrophysics Data System (ADS)

    Gill, J. B.; Michael, P. J.; Dreyer, B. M.; Clague, D. A.; Ramos, F. C.

    2015-12-01

    The Endeavour segment of the Juan de Fuca Ridge is characterized by abundant enriched (E) MORB since the currently inflated axial ridge formed <105 years ago, and by the full range of depleted (D) to E-MORB during the last 2300 years in the km-wide axial graben. Two different styles of enrichment of moderately incompatible elements are present. The first characterized basalts across the ~5 km-wide ridge from >10,000 to ~4000 years ago, whereas the second characterizes more recent basalts erupted in the axial graben. We attribute the first to a higher proportion of pyroxenite to enriched peridotite in the mantle source during ridge inflation. The more recent style reflects the reduced role of pyroxenite after the axial graben formed. The enriched component for both styles is a HIMU-type because it has low 87Sr/86Sr and 176Hf/177Hf relative to 143Nd/144Nd, lower 3He/4He (~8.1 RA) than in the more depleted basalts, shallow slopes on Pb isotope diagrams, and high Nb/LREE ratios. It is regionally widespread and shared with the West Valley and Explorer segments to the north. At least 14 different samplings of mantle components occurred within <1 km of ridge length and width during a time when <1 km of upwelling occurred, indicating that the scale of mantle heterogeneity is <1 km in this setting that is far from a plume.

  18. Microbial conversion of glycerol to 1,3-propanediol

    SciTech Connect

    Zeng, A.P.; Biebl, H.; Deckwer, W.D.

    1996-10-01

    Glycerol is a byproduct from the soap and detergent industry and possibly from future biodiesel plants. The conversion of glycerol to 1,3-propanediol (PD) is of industrial interest due to the potential use of PD for the synthesis of polyesters. We have been studying the microbial conversion of glycerol to PD with work ranging from strain isolation, medium optimization, pathway analysis, product formation kinetics and growth modeling, downstream processing and reactor scale-up (up to 2000 1). PD yields of nearly 100% of the theoretical maximum (0.72 mol/mol glycerol) and final product concentrations of about 65 g/l were achieved with both Klebsiella pneumoniae and Clostridium butyricum. In addition to summarizing our experimental results the advances of bioconversion of glycerol will be reviewed in this presentation, with emphasis on discussing further research and development needs in this area. Results of process engineering and cost analysis will also be presented.

  19. Propane-1,3-diammonium dichromate(VI).

    PubMed

    Trabelsi, Sonia; Marouani, Houda; Al-Deyab, Salem S; Rzaigui, Mohamed

    2012-08-01

    The title compound, (C(3)H(12)N(2))[Cr(2)O(7)], consists of a discrete dichromate anion with an eclipsed conformation and a propane-1,3-diammonium cation. Both kinds of ions have a mirror plane passing through the bridging O atom and the central methyl-ene C atom of the Cr(2)O(7) (2-) and C(3)H(12)N(2) (2+) moieties, respectively. Anions and cations are alternately stacked to form columns parallel to the b axis. Ions are linked by intra- and inter-column hydrogen bonds of types N-H⋯O and C-H⋯O, involving O atoms of the dichromate anions as acceptors, and ammonium or methyl-ene groups as donors.

  20. The vibrational spectra of 1,3-dithiane-1-oxide and 1,3-dithia-1-oxocyclohept-5-ene

    NASA Astrophysics Data System (ADS)

    Noskov, A. I.; Fishman, A. I.; Galjautdinova, A. N.; Klimovitskii, E. N.

    2010-09-01

    The IR spectra of 1,3-dithiane-1-oxide (I) and 1,3-dithia-1-oxocyclohept-5-ene (II) were recorded in solution, solid and liquid phase over 4000-400 cm -1 spectral range. It was found that both (I) and (II) in liquid phase and solutions exist in two conformations: (I) chair-e ( Ce) and chair-a ( Ca) with equatorial and axial positions of the S dbnd O bond, respectively, and (II) chair-e ( Ce) and boat-e ( Be). The intensity variations with temperature (300-180 K) of the bands 632 ( Ca) and 644 cm -1 ( Ce) of (I) in acetone-d 6 and the bands 482 ( Be) и 448 cm -1 ( Ce) of (II) in melt were employed in Van't Hoff plot and gave the values Δ H°( Ca - Ce) = 380 ± 40 cal mol -1 (I) and Δ H° ( Be - Ce) = 400 ± 100 cal mol -1 (II). Ab initio calculations were carried out with the Gaussian 98 program using the basis set 6-31G(d) for (I) and 6-311++G(d,p) for (II). The energy difference between Ca and Ce conformations for (I) and Be and Ce for (II) are in a good agreement with experimental results. Vibrational frequencies for both conformations (I) and (II) were calculated. After appropriate scaling a reasonably good agreement between the experimental and calculated wave numbers was obtained.

  1. Alkaline hydrolysis of hexahydro-1,3,5-trinitro-1,3,5-triazine: M06-2X investigation.

    PubMed

    Sviatenko, Liudmyla K; Gorb, Leonid; Hill, Frances C; Leszczynska, Danuta; Okovytyy, Sergiy I; Leszczynski, Jerzy

    2015-09-01

    Alkaline hydrolysis mechanism of possible environmental contaminant RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) was investigated computationally at the PCM(Pauling)/M06-2X/6-311++G(d,p) level of theory. Results obtained show that the initial deprotonation of RDX by hydroxide leads to nitrite elimination and formation of a denitrated cyclohexene intermediate. Further nucleophilic attack by hydroxide onto cyclic CN double bond results in ring opening. It was shown that the presence of hydroxide is crucial for this stage of the reaction. The dominant decomposition pathway leading to a ring-opened intermediate was found to be formation of 4-nitro-2,4-diazabutanal. Hydrolytic transformation of its byproduct (methylene nitramine) leads to end products such as formaldehyde and nitrous oxide. Computational results are in a good agreement with experimental data on hydrolysis of RDX, suggesting that 4-nitro-2,4-diazabutanal, nitrite, formaldehyde, and nitrous oxide are main products for early stages of RDX decomposition under alkaline conditions.

  2. Microbially Mediated Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5- Triazine by Extracellular Electron Shuttling Compounds

    PubMed Central

    Kwon, Man Jae; Finneran, Kevin T.

    2006-01-01

    The potential for humic substances to stimulate the reduction of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was investigated. This study describes a novel approach for the remediation of RDX-contaminated environments using microbially mediated electron shuttling. Incubations without cells demonstrated that reduced AQDS transfers electrons directly to RDX, which was reduced without significant accumulation of the nitroso intermediates. Three times as much reduced AQDS (molar basis) was needed to completely reduce RDX. The rate and extent of RDX reduction differed greatly among electron shuttle/acceptor amendments for resting cell suspensions of Geobacter metallireducens and G. sulfurreducens with acetate as the sole electron donor. AQDS and purified humic substances stimulated the fastest rate of RDX reduction. The nitroso metabolites did not significantly accumulate in the presence of AQDS or humic substances. RDX reduction in the presence of poorly crystalline Fe(III) was relatively slow and metabolites transiently accumulated. However, adding humic substances or AQDS to Fe(III)-containing incubations increased the reduction rates. Cells of G. metallireducens alone reduced RDX; however, the rate of RDX reduction was slow relative to AQDS-amended incubations. These data suggest that extracellular electron shuttle-mediated RDX transformation is not organism specific but rather is catalyzed by multiple Fe(III)- and humic-reducing species. Electron shuttle-mediated RDX reduction may eventually become a rapid and effective cleanup strategy in both Fe(III)-rich and Fe(III)-poor environments. PMID:16957213

  3. A novel dilithiation approach to 3,4-dihydro-2H-1,3-benzothiazines, 3,4-Dihydro-2H-1,3-benzoxazines, and 2,3,4,5-tetrahydro-1,3-benzothiazepines.

    PubMed

    Katritzky, Alan R; Xu, Yong-Jiang; Jain, Ritu

    2002-11-15

    3,4-Dihydro-2H-1,3-benzothiazines 4, 3,4-dihydro-2H-1,3-benzoxazines 9, and 2,3,4,5-tetrahydro-1,3-benzothiazepines 6 were synthesized by directed ortho-lithiation of thiophenols and phenols and by side-chain lithiation of substituted thiophenols, respectively, in one-pot by reacting with N,N-bis[(benzotriazol-1-yl)methyl]amines 3 as 1,3-biselectrophile synthons.

  4. Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

    PubMed Central

    Moreno, Claudia M; Dixon, Rose E; Tajada, Sendoa; Yuan, Can; Opitz-Araya, Ximena; Binder, Marc D; Santana, Luis F

    2016-01-01

    CaV1.3 channels regulate excitability in many neurons. As is the case for all voltage-gated channels, it is widely assumed that individual CaV1.3 channels behave independently with respect to voltage-activation, open probability, and facilitation. Here, we report the results of super-resolution imaging, optogenetic, and electrophysiological measurements that refute this long-held view. We found that the short channel isoform (CaV1.3S), but not the long (CaV1.3L), associates in functional clusters of two or more channels that open cooperatively, facilitating Ca2+ influx. CaV1.3S channels are coupled via a C-terminus-to-C-terminus interaction that requires binding of the incoming Ca2+ to calmodulin (CaM) and subsequent binding of CaM to the pre-IQ domain of the channels. Physically-coupled channels facilitate Ca2+ currents as a consequence of their higher open probabilities, leading to increased firing rates in rat hippocampal neurons. We propose that cooperative gating of CaV1.3S channels represents a mechanism for the regulation of Ca2+ signaling and electrical activity. DOI: http://dx.doi.org/10.7554/eLife.15744.001 PMID:27187148

  5. Lutein, a Natural Carotenoid, Induces α-1,3-Glucan Accumulation on the Cell Wall Surface of Fungal Plant Pathogens.

    PubMed

    Otaka, Junnosuke; Seo, Shigemi; Nishimura, Marie

    2016-07-28

    α-1,3-Glucan, a component of the fungal cell wall, is a refractory polysaccharide for most plants. Previously, we showed that various fungal plant pathogens masked their cell wall surfaces with α-1,3-glucan to evade plant immunity. This surface accumulation of α-1,3-glucan was infection specific, suggesting that plant factors might induce its production in fungi. Through immunofluorescence observations of fungal cell walls, we found that carrot (Daucus carota) extract induced the accumulation of α-1,3-glucan on germlings in Colletotrichum fioriniae, a polyphagous fungal pathogen that causes anthracnose disease in various dicot plants. Bioassay-guided fractionation of carrot leaf extract successfully identified two active substances that caused α-1,3-glucan accumulation in this fungus: lutein, a carotenoid widely distributed in plants, and stigmasterol, a plant-specific membrane component. Lutein, which had a greater effect on C. fioriniae, also induced α-1,3-glucan accumulation in other Colletotrichum species and in the phylogenetically distant rice pathogen Cochliobolus miyabeanus, but not in the rice pathogen Magnaporthe oryzae belonging to the same phylogenetic subclass as Colletotrichum. Our results suggested that fungal plant pathogens reorganize their cell wall components in response to specific plant-derived compounds, which these pathogens may encounter during infection.

  6. Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.

    PubMed

    Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura

    2016-05-01

    Ca(2+) signaling controls activation and effector functions of T lymphocytes. Ca(2+) levels also regulate NFAT activation and CD40 ligand (CD40L) expression in T cells. CD40L in activated memory T cells binds to its cognate receptor, CD40, on other cell types resulting in the production of antibodies and pro-inflammatory mediators. The CD40L/CD40 interaction is implicated in the pathogenesis of autoimmune disorders and CD40L is widely recognized as a therapeutic target. Ca(2+) signaling in T cells is regulated by Kv1.3 channels. We have developed lipid nanoparticles that deliver Kv1.3 siRNAs (Kv1.3-NPs) selectively to CD45RO(+) memory T cells and reduce the activation-induced Ca(2+) influx. Herein we report that Kv1.3-NPs reduced NFAT activation and CD40L expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naïve. These findings indicate that Kv1.3-NPs operate as targeted immune suppressive agents with promising therapeutic potentials.

  7. MODIS 3 Km Aerosol Product: Applications over Land in an Urban/suburban Region

    NASA Technical Reports Server (NTRS)

    Munchak, L. A.; Levy, R. C.; Mattoo, S.; Remer, L. A.; Holben, B. N.; Schafer, J. S.; Hostetler, C. A.; Ferrare, R. A.

    2013-01-01

    MODerate resolution Imaging Spectroradiometer (MODIS) instruments aboard the Terra and Aqua satellites have provided a rich dataset of aerosol information at a 10 km spatial scale. Although originally intended for climate applications, the air quality community quickly became interested in using the MODIS aerosol data. However, 10 km resolution is not sufficient to resolve local scale aerosol features. With this in mind, MODIS Collection 6 is including a global aerosol product with a 3 km resolution. Here, we evaluate the 3 km product over the Baltimore/Washington D.C., USA, corridor during the summer of 2011, by comparing with spatially dense data collected as part of the DISCOVER-AQ campaign these data were measured by the NASA Langley Research Center airborne High Spectral Resolution Lidar (HSRL) and a network of 44 sun photometers (SP) spaced approximately 10 km apart. The HSRL instrument shows that AOD can vary by up to 0.2 within a single 10 km MODIS pixel, meaning that higher resolution satellite retrievals may help to characterize aerosol spatial distributions in this region. Different techniques for validating a high-resolution aerosol product against SP measurements are considered. Although the 10 km product is more statistically reliable than the 3 km product, the 3 km product still performs acceptably, with more than two-thirds of MODIS/SP collocations falling within the expected error envelope with high correlation (R > 0.90). The 3 km product can better resolve aerosol gradients and retrieve closer to clouds and shorelines than the 10 km product, but tends to show more significant noise especially in urban areas. This urban degradation is quantified using ancillary land cover data. Overall, we show that the MODIS 3 km product adds new information to the existing set of satellite derived aerosol products and validates well over the region, but due to noise and problems in urban areas, should be treated with some degree of caution.

  8. Variations in Km(CO2) of Ribulose-1,5-bisphosphate Carboxylase among Grasses

    PubMed Central

    Yeoh, Hock-Hin; Badger, Murray R.; Watson, Leslie

    1980-01-01

    A survey of the Km(CO2) values of ribulose-1,5-bisphosphate carboxylase from 60 grass species shows that enzyme from C3 grasses consistently exhibits lower Km(CO2) than does that from C4 grasses. Systematically ordered variation in Km(CO2) of ribulose-1,5-bisphosphate carboxylases from C3 and C4 grasses is also apparent and, among C4 grasses, this shows some correlation with C4 types. PMID:16661586

  9. Cratering and penetration experiments in Teflon targets at velocities from 1 to 7 km/s

    NASA Technical Reports Server (NTRS)

    Hoerz, Friedrich; Bernhard, Ronald P.; Cintala, Mark J.; See, Thomas H.

    1995-01-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility (LDEF) after the spacecraft had spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments in an effort to reproduce such features and to -- hopefully -- understand the relationships between projectile size and the resulting crater or penetration-hole diameter over a wide range of impact velocity. Such relationships are needed to derive the size- and mass-frequency distribution and flux of natural and man-made particles in low-Earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres of 3.175 mm (1/8 inch) nominal diameter (Dp) into pure Teflon FEP targets at velocities ranging from 1 to 7 km/s. Target thickness (T) was varied over more than three orders of magnitude from infinite halfspace targets (Dp/T less than 0.1) to very thin films (Dp/T greater than 100). Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration-hole diameter (Dh) can become larger than that of a standard crater (Dc) at relative target thicknesses of Dp/T = 0.6-0.9. The crater diameter is infinite halfspace Teflon targets increases -- at otherwise constant impact conditions -- with encounter velocity by a factor of V0.44. In contrast, the penetration-hole size is very thin foils (Dp/T greater than 50) is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is

  10. Cratering and penetration experiments in teflon targets at velocities from 1 to 7 km/s

    NASA Technical Reports Server (NTRS)

    Horz, Friedrich; Cintala, Mark; Bernhard, Ronald P.; Cardenas, Frank; Davidson, William; Haynes, Gerald; See, Thomas H.; Winkler, Jerry; Knight, Jeffrey

    1994-01-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility after the spacecraft spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments to reproduce such features and to understand the relationships between projectile size and the resulting crater or penetration hole diameter over a wide range of impact velocities. Such relationships are needed to derive the size and mass frequency distribution and flux of natural and man-made particles in low-earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres into pure Teflon targets at velocities ranging from 1 to 7 km/s. Target thickness varied over more than three orders of magnitude from finite halfspace targets to very thin films. Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration hole diameter can become larger than that of a standard crater. The crater diameter in infinite halfspace Teflon targets increases, at otherwise constant impact conditions, with encounter velocity by a factor of V (exp 0.44). In contrast, the penetration hole size in very thin foils is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is sufficiently systematic and complete, up to 7 km/s, to make reasonable recommendations for velocity-scaling of Teflon craters and penetrations. We specifically suggest that cratering behavior and associated equations apply

  11. Cratering and penetration experiments in Teflon targets at velocities from 1 to 7 km/s

    NASA Astrophysics Data System (ADS)

    Hoerz, Friedrich; Bernhard, Ronald P.; Cintala, Mark J.; See, Thomas H.

    1995-02-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility (LDEF) after the spacecraft had spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments in an effort to reproduce such features and to -- hopefully -- understand the relationships between projectile size and the resulting crater or penetration-hole diameter over a wide range of impact velocity. Such relationships are needed to derive the size- and mass-frequency distribution and flux of natural and man-made particles in low-Earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres of 3.175 mm (1/8 inch) nominal diameter (Dp) into pure Teflon FEP targets at velocities ranging from 1 to 7 km/s. Target thickness (T) was varied over more than three orders of magnitude from infinite halfspace targets (Dp/T less than 0.1) to very thin films (Dp/T greater than 100). Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration-hole diameter (Dh) can become larger than that of a standard crater (Dc) at relative target thicknesses of Dp/T = 0.6-0.9. The crater diameter is infinite halfspace Teflon targets increases -- at otherwise constant impact conditions -- with encounter velocity by a factor of V0.44. In contrast, the penetration-hole size is very thin foils (Dp/T greater than 50) is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is

  12. Microwave Plasma Chemical Vapor Deposition of Carbon Coatings on LiNi1/3Co1/3Mn1/3O2 for Li-Ion Battery Composite Cathodes

    SciTech Connect

    Doeff, M.M.; Kostecki, R.; Marcinek, M.; Wilcoc, J.D.

    2008-12-10

    In this paper, we report results of a novel synthesis method of thin film conductive carbon coatings on LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} cathode active material powders for lithium-ion batteries. Thin layers of graphitic carbon were produced from a solid organic precursor, anthracene, by a one-step microwave plasma chemical vapor deposition (MPCVD) method. The structure and morphology of the carbon coatings were examined using SEM, TEM, and Raman spectroscopy. The composite LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} electrodes were electrochemically tested in lithium half coin cells. The composite cathodes made of the carbon-coated LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} powder showed superior electrochemical performance and increased capacity compared to standard composite LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} electrodes.

  13. Effects of Microstructure on Electrode Properties of Nanosheet-Derived Hx(Ni1/3Co1/3Mn1/3)O2 for Electrochemical Capacitors

    PubMed Central

    Yano, Masato; Suzuki, Shinya; Miyayama, Masaru; Ohgaki, Masataka

    2013-01-01

    Nanosheet-derived Hx(Ni1/3Co1/3Mn1/3)O2 was prepared by restacking (Ni1/3Co1/3Mn1/3)O2 nanosheets with large or small lateral sizes and their electrochemical properties in a 1 M KOH aqueous solution; microstructural factors were compared with those of bulk Hx(Ni1/3Co1/3Mn1/3)O2 (HNCM). The electrodes composed of small nanosheets exhibited very large capacitances of 1241 F·g−1 (395 mAh·g−1) at a current density of 50 mA·g−1, and 430 F·g−1 (100 mAh·g−1) at a large current density of 1000 mA·g−1. These large capacitances resulted from a heterogeneous layer structure with a large surface area and pore volume. The electrodes of large nanosheets, with a strongly interconnected microstructure and a surface area slightly larger than that of HNCM, exhibited good cycle stability and capacitances larger than that of HNCM. Microstructural control through the restacking of (Ni1/3Co1/3Mn1/3)O2 nanosheets improved the electrochemical properties of Hx(Ni, Co, Mn)O2.

  14. Running Performance, Nationality, Sex and Age in 10km, Half-marathon, Marathon and 100km Ultra-marathon IAAF 1999-2015.

    PubMed

    Nikolaidis, Pantelis T; Onywera, Vincent O; Knechtle, Beat

    2016-10-13

    The aim of the present study was to examine the performance of the world's best runners in 10km, half-marathon, marathon and 100km by age, sex and nationality during 1999-2015 using data from International Association of Athletics Federations (IAAF). A total of 38,895 runners (17,136 women and 21,759 men) were considered with 2,594 (1,360 women and 1,234 male) in 10km, 11,595 (5,225 women and 6,370 male) in half-marathon, 23,973 (10,208 women and 13,765 male) in marathon and 733 (343 women and 390 male) in 100km. Most of the runners in 10km (women 40%, men 67%) and half-marathon (women 30%, men 57%) were Kenyans. In marathon, most female and male runners were Ethiopians (women 17%, men 14%) and Kenyans (women 15%, men 43%), respectively. In 100km, most runners were Japanese (20% in women and men). Women were older than men in 10km (32.0±6.0 versus 25.3±4.3 years, p<0.001), half-marathon (27.5±4.7 versus 25.9±4.1 years, p<0.001) and marathon (29.5±5.5 versus 29.1±4.3 years, p<0.001), but not in 100km (36.6±6.1 versus 35.9±5.5 years, p=0.097). Men were faster than women in 10km (28:04±0:17 versus 32:08±0.31 min:sec, p<0.001), half-marathon (1:01:58±0:00:52 versus 1:11:21±0:01:18 h:min:sec, p<0.001), marathon (2:13:42±0:03:01 versus 2:35:04±0:05:21 h:min:s, p<0.001), and 100km (6:48:01±0:11:29 versus 7:53:51±0:16:37 h:min:sec, p<0.001). East-Africans were not the fastest compared to athletes originating from other countries where only Ethiopian men were faster than all other men in marathon. In summary, (i) most runners were from Kenya and Ethiopia in 10km, half-marathon and marathon, but from Japan and Russia in 100km, (ii) women were older than men in all distances except 100km, (iii) men were the fastest in all distances, and (iii) Ethiopian men were faster than all other men in marathon.

  15. Potential of KM3NeT to observe galactic neutrino point-like sources

    NASA Astrophysics Data System (ADS)

    Trovato, Agata

    2016-07-01

    KM3NeT (http://www.km3net.org">http://www.km3net.org) will be the next-generation cubic-kilometre-scale neutrino telescope to be installed in the depths of the Mediterranean Sea. This location will allow for surveying the Galactic Centre, most of the Galactic Plane as well as a large part of the sky. We report KM3NeT discovery potential for the SNR RXJ1713.7-3946 and the PWN Vela X and its sensitivity to point-like sources with an E-2 spectrum.

  16. Protective effect of kombucha mushroom (KM) tea on phenol-induced cytotoxicity in albino mice.

    PubMed

    Yapar, Kursad; Cavusoglu, Kultigin; Oruc, Ertan; Yalcin, Emine

    2010-09-01

    The present study was carried out to evaluate the protective role of kombucha mushroom (KM) tea on cytotoxicity induced by phenol (PHE) in mice. We used weight gain and micronucleus (MN) frequency as indicators of cytotoxicity and supported these parameters with pathological findings. The animals were randomly divided into seven groups: (Group I) only tap water (Group II) 1000 microl kg(-1) b. wt KM-tea, (Group III) 35 mg kg(-1) body wt. PHE (Group IV) 35 mg kg(-1) body wt. PHE + 250 microl kg(-1) b. wt KM-tea (Group V) 35 mg kg(-1) b. wt PHE + 500 microl kg(-1) b. wt KM-tea (Group VI) 35 mg kg(-1) b. wt PHE + 750 microl kg(-1) b. wt KM-tea, (Group VII) 35 mg kg(-1) b. wt PHE + 1000 microl kg(-1) b. wt KM-tea, for 20 consecutive days by oral gavage. The results indicated that all KM-tea supplemented mice showed a lower MN frequency than erythrocytes in only PHE-treated group. There was an observable regression on account of lesions in tissues of mice supplemented with different doses of KM-tea in histopathological observations. In conclusion, the KM-tea supplementation decreases cytotoxicity induced by PHE and its protective role is dose-dependent.

  17. Toxic effects of oral hexahydro-1,3,5-trinitro-1,3,5-triazine in the western fence lizard (Sceloporus occidentalis).

    PubMed

    McFarland, Craig A; Quinn, Michael J; Bazar, Matthew A; Talent, Larry G; Johnson, Mark S

    2009-05-01

    Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been widely used as an explosive in munition formulations, resulting in contamination of wildlife habitat on military installations. To estimate health effects for reptilian species, acute, subacute, and subchronic oral toxicity studies were conducted using the Western fence lizard (Sceloporus occidentalis). Estimated oral median lethal doses were 72 (95% confidence interval [CI], 49-106) mg/kg body weight (slope, 3.754) for males and 88 (95% CI, 65-119) mg/kg (slope, 4.525) for females. Toxicity from RDX suggested the neurological system as the critical target tissue. A 14-d subacute study followed with males dosed orally with RDX (corn oil) at 0, 10, 20, 25, 30, 45, and 60 mg/kg/d. Signs of toxicity frequently included a characteristic body posture. A significant dose-survival relationship was seen over the range of doses, with a significant decrease in survival at 20 mg/kg/d. Males in the 60-d subchronic study were dosed at 0, 1, 2.5, 5, 8, and 11 mg/kg/d, and signs of toxicity included lethargy, cachexia, and anorexia. Survival was decreased at 8 and 11 mg/kg/d. Reduced growth rate and food consumption occurred at 5 mg/kg/d. Brain tissue was assayed for RDX when seizures were observed at a residue concentration of at least 18 microg/g. No abnormalities were observed in the hematologic indices, whereas plasma proteins were reduced. Hepatic enlargement and decreased testes mass occurred at 8 and 11 mg/kg/d. Plasma testosterone concentrations, sperm counts, and motility measures were variable for all treatment levels. Based on survival, growth rate, food intake, and testes to brain weight ratios, these data suggest a lowest-observed-adverse effect level of 5 mg/kg/d and a no-observed-adverse effect level of 2.5 mg/kg/d.

  18. Accumulation of hexahydro- 1,3,5-trinitro- 1,3,5-triazine in channel catfish (Ictalurus punctatus) and aquatic oligochaetes (Lumbriculus variegatus).

    PubMed

    Belden, Jason B; Lotufo, Guilherme R; Lydy, Michael J

    2005-08-01

    The extensively used military explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been widely released to the environment during production, usage, and disposal operations. Toxic effects of RDX have been reported in terrestrial and aquatic receptors, but investigations regarding the bioaccumulation potential of RDX in aquatic systems are scarce. The objective of the present study was to describe the toxicokinetics of RDX during aqueous exposure for the channel catfish (Ictalurus punctatus) and aquatic oligochaetes (Lumbriculus variegatus) and to compare the amount of RDX accumulation in juvenile catfish following aqueous exposure only, dietary exposure only, and a combination of dietary and aqueous exposure. The toxicokinetics measurements included bioconcentration factors (BCFs), uptake rates, elimination rates, and biological half-lives. First-order, single-compartment models described the toxicokinetics for both species. Uptake of RDX into oligochaetes was relatively rapid (uptake clearance constant [k(u)] of 5.17 ml/g/h) compared to that in catfish (k(u) = 1.28 ml/g/h). However, elimination also was more rapid in oligochaetes, with biological half-lives of 0.28 and 1.09 h for oligochaetes and catfish, respectively. Thus, both species had very similar estimated BCFs of 2.1 ml/g for oligochaetes and 2.0 ml/g for catfish. Accumulation of RDX in fish that were fed oligochaetes exposed to an exceedingly high water concentration of RDX was minimal. The present investigation indicates that RDX uptake via the aqueous route is the expected dominant uptake pathway, with dietary uptake contributing minimally to the overall body burden in fish inhabiting RDX-contaminated sites. Because of the exceedingly low bioaccumulative potential and low reported toxicity of RDX, the presence of this explosive in aquatic systems is unlikely to pose unacceptable risks to invertebrates and fish.

  19. The refurbished 1.3-m Robotically Controlled Telescope at Kitt Peak

    NASA Astrophysics Data System (ADS)

    Gelderman, R.; Guinan, E.; Howell, S.; Mattox, J. R.; McGruder, C. H.; Walter, D. K.; Davis, D. R.; Everett, M.

    2003-05-01

    In 1999, the National Optical Astronomy Observatories (NOAO) announced the opportunity to "assume responsibility for operation of the Kitt Peak 1.3-m telescope." A group of astronomers/educators from institutions across the USA successfully proposed to refurbish and automate the observatory and operate it as the Robotically Controlled Telescope (RCT). The RCT Consortium has been established between Francis Marion University, the Planetary Science Institute, South Carolina State University, Villanova University, and Western Kentucky University to oversee the refurbishment and automation, and operate the telescope to successfully achieve its research and education goals. The RCT was commissioned in 1964 as the Remotely Controlled Telescope and utilized that epoch's computing and communication technology to provide unattended operation from NOAO headquarters in Tucson, about 90 km distant. The original incarnation of the RCT allowed astronomers to gain experience in the remote operation of observatories in order to both develop techniques for operating space-based telescopes and to increase the productivity of ground-based telescopes (Maran 1967 Science 158, 867). While these tests worked as well as could be expected given the technology of the time, the telescope and observatory were refitted in 1969 for classical, attended operations. The second life of the 1.3-m was as a heavily subscribed KPNO visitor facility, first with photoelectric photometers and later as an important testbed for the newest infrared instrumentation. In 1996 the telescope was removed from the list of available KPNO facilities and stood idle until the RCT Consortium hired EOS Technologies, Inc. to refurbish and automate the observatory. In winter 2003 most of the observatory systems have been refurbished and the commissioning has begun. Refurbishment of the RCT has been made possible by NASA grant NAG58762.

  20. Wide-Bandgap Semiconductors

    SciTech Connect

    Chinthavali, M.S.

    2005-11-22

    With the increase in demand for more efficient, higher-power, and higher-temperature operation of power converters, design engineers face the challenge of increasing the efficiency and power density of converters [1, 2]. Development in power semiconductors is vital for achieving the design goals set by the industry. Silicon (Si) power devices have reached their theoretical limits in terms of higher-temperature and higher-power operation by virtue of the physical properties of the material. To overcome these limitations, research has focused on wide-bandgap materials such as silicon carbide (SiC), gallium nitride (GaN), and diamond because of their superior material advantages such as large bandgap, high thermal conductivity, and high critical breakdown field strength. Diamond is the ultimate material for power devices because of its greater than tenfold improvement in electrical properties compared with silicon; however, it is more suited for higher-voltage (grid level) higher-power applications based on the intrinsic properties of the material [3]. GaN and SiC power devices have similar performance improvements over Si power devices. GaN performs only slightly better than SiC. Both SiC and GaN have processing issues that need to be resolved before they can seriously challenge Si power devices; however, SiC is at a more technically advanced stage than GaN. SiC is considered to be the best transition material for future power devices before high-power diamond device technology matures. Since SiC power devices have lower losses than Si devices, SiC-based power converters are more efficient. With the high-temperature operation capability of SiC, thermal management requirements are reduced; therefore, a smaller heat sink would be sufficient. In addition, since SiC power devices can be switched at higher frequencies, smaller passive components are required in power converters. Smaller heat sinks and passive components result in higher-power-density power converters

  1. Crustal thinning in the northern Tyrrhenian Rift: Insights from multichannel and wide-angle seismic data across the basin

    NASA Astrophysics Data System (ADS)

    Moeller, S.; Grevemeyer, I.; Ranero, C. R.; Berndt, C.; Klaeschen, D.; Sallares, V.; Zitellini, N.; Franco, R.

    2014-03-01

    Extension of the continental lithosphere leads to the formation of rift basins or rifted continental margins if breakup occurs. Seismic investigations have repeatedly shown that conjugate margins have asymmetric tectonic structures and different amount of extension and crustal thinning. Here we compare two coincident wide-angle and multichannel seismic profiles across the northern Tyrrhenian rift system sampling crust that underwent different stages of extension from north to south and from the flanks to the basin center. Tomographic inversion reveals that the crust has thinned homogeneously from ~24 km to ~17 km between the Corsica Margin and the Latium Margin implying a β factor of ~1.3-1.5. On the transect 80 km to the south, the crust thinned from ~24 km beneath Sardinia to a maximum of ~11 km in the eastern region near the Campania Margin (β factor of ~2.2). The increased crustal thinning is accompanied by a zone of reduced velocities in the upper crust that expands progressively toward the southeast. We interpret that the velocity reduction is related to rock fracturing caused by a higher degree of brittle faulting, as observed on multichannel seismic images. Locally, basalt flows are imaged intruding sediment in this zone, and heat flow values locally exceed 100 mW/m2. Velocities within the entire crust range 4.0-6.7 km/s, which are typical for continental rocks and indicate that significant rift-related magmatic underplating may not be present. The characteristics of the pre-tectonic, syn-tectonic and post-tectonic sedimentary units allow us to infer the spatial and temporal evolution of active rifting. In the western part of the southern transect, thick postrift sediments were deposited in half grabens that are bounded by large fault blocks. Fault spacing and block size diminish to the east as crustal thinning increases. Recent tectonic activity is expressed by faults cutting the seafloor in the east, near the mainland of Italy. The two transects show

  2. Synthesis and antimicrobial activity of styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl amines and styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-thiadiazolyl amines.

    PubMed

    Sravya, G; Yamini, G; Padmavathi, V; Padmaja, A

    2016-10-21

    A new class of mono and bis heterocycles - styryl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines, pyrrolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines and pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines were prepared from the synthetic intermediate Z-styrylsulfonylacetic acid adopting simple and well versed synthetic methodologies and studied their antimicrobial activity. Amongst all the tested compounds styryl thiadiazole 5c exhibited promising antimicrobial activity against Pseudomonas aeruginosa and Penicillium chrysogenum.

  3. Toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine to larval zebrafish (Danio rerio)

    USGS Publications Warehouse

    Mukhi, S.; Pan, X.; Cobb, G.P.; Patino, R.

    2005-01-01

    Hexahydro-1,3,5-trinitro-1,3,5-triazine, a cyclonitramine commonly known as RDX, is used in the production of military munitions. Contamination of soil, sediment, and ground and surface waters with RDX has been reported in different places around the world. Acute and subacute toxicities of RDX have been relatively well documented in terrestrial vertebrates, but among aquatic vertebrates the information available is limited. The objective of this study was to characterize the acute toxicity of RDX to larval zebrafish. Mortality (LC50) and incidence of vertebral column deformities (EC50) were two of the end points measured in this study. The 96-h LC50 was estimated at 22.98 and 25.64 mg l-1 in two different tests. The estimated no-observed-effective- concentration (NOEC) values of RDX on lethality were 13.27 ?? 0.05 and 15.32 ?? 0.30 mg l-1; and the lowest-observed-effective- concentration (LOEC) values were 16.52 ?? 0.05 and 19.09 ?? 0.23 mg l-1 in these two tests, respectively. The 96-h EC50 for vertebral deformities on survivors from one of the acute lethality tests was estimated at 20.84 mg l-1, with NOEC and LOEC of 9.75 ?? 0.34 and 12.84 ?? 0.34 mg l-1, respectively. Behavioral aberrations were also noted in this acute toxicity study, including the occurrence of whirling movement and lethargic behavior. The acute effects of RDX on survival, incidence of deformities, and behavior of larval zebrafish occurred at the high end of the most frequently reported concentrations of RDX in aquatic environments. The chronic effects of RDX in aquatic vertebrates need to be determined for an adequate assessment of the ecological risk of environmental RDX. ?? 2005 Elsevier Ltd. All rights reserved.

  4. Hayward Fault: A 50-km-long Locked Patch Regulates Its Large Earthquake Cycle (Invited)

    NASA Astrophysics Data System (ADS)

    Lienkaemper, J. J.; Simpson, R. W.; Williams, P. L.; McFarland, F. S.; Caskey, S. J.

    2010-12-01

    We have documented a chronology of 11 paleoearthquakes on the southern Hayward fault (HS) preceding the Mw6.8, 1868 earthquake. These large earthquakes were both regular and frequent, as indicated by a 0.40 coefficient of variation and mean recurrence interval (MRI) of 161 ± 65 yr (1σ of recurrence intervals). Furthermore, the Oxcal-modeled probability distribution for the average interval resembles a Gaussian rather than a more irregular Brownian passage time distribution. Our revised 3D-modeling of subsurface creep, using newly updated long-term creep rates, now suggests there is only one ~50-km-long locked patch (instead of two), confined laterally between two large patches of deep creep (≥9 km), with an extent consistent with evidence for the 1868 rupture. This locked patch and the fault’s lowest rates of surface creep are approximately centered on HS’s largest bend and a large gabbro body, particularly where the gabbro forms both east and west faces of the fault. We suggest that this locked patch serves as a mechanical capacitor, limiting earthquake size and frequency. The moment accumulation over 161 yr summed on all locked elements of the model reaches Mw6.79, but if half of the moment stored in the creeping elements were to fail dynamically, Mw could reach 6.91. The paleoearthquake histories for nearby faults of the San Francisco Bay region appear to indicate less regular and frequent earthquakes, possibly because most lack the high proportion (40-60%) of aseismic release found on the Hayward fault. The northernmost Hayward fault and Rodgers Creek fault (RCF) appear to rupture only half as frequently as the HS and are separated from the HS by a creep buffer and 5-km wide releasing bend respectively, both tending to limit through-going ruptures. The paleoseismic record allows multi-segment, Hayward fault-RCF ruptures, but does not require it. The 1868 HS rupture preceded the 1906 multi-segmented San Andreas fault (SAF) rupture, perhaps because the HS

  5. Polymerization of 1,3-Dienes with Functional Groups. 4.

    NASA Astrophysics Data System (ADS)

    Takenaka, Katsuhiko; Shibata, Natsuyo; Tsuchida, Shinsuke; Takeshita, Hiroki; Miya, Masamitsu; Shiomi, Tomoo

    Anionic polymerization of N,N-diethyl-2-methylene-3-butenamide (DEA), which is a 1,3-butadiene derivative containing a diethylamide function, was carried out in tetrahydrofurane (THF) under various conditions. When DEA was polymerized in THF at -78°C using potassium naphthalenide (K-Naph) or diphenylmethylpotassium (DPMK) as an initiator, a polymer of predictable molecular weight with a narrow molecular weight distribution was obtained. However, the rate of polymerization was extremely slow to reach 80% conversion after 720 h. When the polymerization temperature was raised to 20°C, a low molecular weight oligomer with a broad molecular weight distribution was obtained because of a chain transfer reaction. On the other hand, no such side reaction occurred even at 20°C, when polymerization was carried out in the presence of LiCl. Also, the chain transfer reaction did not occur in lithium naphthalenide (Li-Naph) initiated polymerization. The microstructure of the polymer prepared using a potassium counter cation was a 1 : 1 mixture of 1,4-E and 1,2- structures. In the case of Li-Naph or DPMK/LiCl systems, the microstructure was a complicated mixture of 1,4-E, 1,4-Z, and 1,2-structures.

  6. Species differences in metabolism of 1,3-butadiene

    SciTech Connect

    Henderson, R.F.

    1995-02-01

    1,3-Butadiene (BD) is a 4-carbon gaseous compound with two double bonds. Used in high tonnage to make styrene-butadiene polymers in the rubber industry. Because of large amounts in use, BD was tested for toxicity in 2-year inhalation exposures of both Sprague-Dawley rats and B6C3F{sub 1} mice. The results of the two-species studies were dramatically different. In the initial study in mice, BD was shown to be a potent multiple-site carcinogen at exposure levels of 625 and 1250 ppM. There were increased incidences of neoplasia in the heart, lung, mammary gland, and ovary; malignant lymphomas resulted in early deaths of the mice so that the planned 2-year study was stopped after only 61 weeks of exposure. The second study in mice was conducted at much lower exposure concentrations (6.25, 20, 62.5, 200, and 625 ppM) and lasted 104 weeks. Increased incidences of hemangiosarcomas of the heart and lung neoplasia were observed in males exposed to 62.5 ppM BD, while females had increased lung neoplasia even at the 6.25 ppM exposure level. Early deaths from lymphomas were again observed at the high exposure concentration (625 ppm). A noncancer toxicity observed in mice was a macrocytic, megaloblastic anemia.

  7. Features of electron and phonon processes in GaSb FeGa1.3 eutectics

    NASA Astrophysics Data System (ADS)

    Aliyev, M. I.; Khalilova, A. A.; Arasly, D. H.; Rahimov, R. N.; Tanoglu, M.; Ozyuzer, L.

    2003-11-01

    Eutectic alloys of GaSb-FeGa1.3 were prepared by the vertical Bridgman method. A microstructure with the needle-shaped metallic FeGa1.3 phase oriented in a specific direction and uniformly distributed within the GaSb matrix was obtained. In GaSb-FeGa1.3 eutectics, the electrical and thermal conductivity, thermal diffusivity, thermoelectric power and Hall coefficients were investigated in a wide temperature range. These properties were measured at different mutual directions of current, thermal flow, magnetic field and metal phase inclusions. The influence of metallic inclusions on these properties was revealed and the distinctive characteristics of electron and phonon processes were established.

  8. Changes in Body Mass, Hydration and Electrolytes Following a 161-km Endurance Race

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Purpose: To examine electrolyte concentrations and changes in body mass and total body water (TBW) during a 161-km ultra-marathon, and relate these to finish time and incidence of hyponatremia. Methods: Subjects were recruited from the 161-km 2008 Rio Del Lago Endurance Race. Body mass, TBW, and s...

  9. New Marker Development for the Rice Blast Resistance Gene Pi-km

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The blast resistance (R) gene Pi-km protects rice against specific races of the fungal pathogen Magnaporthe oryzae. The use of blast R genes remains the most cost-effective method of disease control. To facilitate the breeding process, we developed a Pi-km specific molecular marker. For this purp...

  10. Draft genome sequence of the Bordetella bronchiseptica swine isolate KM22

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Bordetella bronchiseptica swine isolate KM22 has been used in experimental infections of swine as a model of clinical B. bronchiseptica infections within swine herds and to study host-to-host transmission. Here we report the draft genome sequence of KM22....

  11. A Co-Creation Blended KM Model for Cultivating Critical-Thinking Skills

    ERIC Educational Resources Information Center

    Yeh, Yu-chu

    2012-01-01

    Both critical thinking (CT) and knowledge management (KM) skills are necessary elements for a university student's success. Therefore, this study developed a co-creation blended KM model to cultivate university students' CT skills and to explore the underlying mechanisms for achieving success. Thirty-one university students participated in this…

  12. Variation of electron and ion density distribution along Earth's magnetic field line deduced from whistler mode (wm) sounding of image/rpi satellite below altitude 5000 km

    NASA Astrophysics Data System (ADS)

    Hazra, Susmita

    This thesis provides a detailed survey and analysis of whistler mode (WM) echoes observed by IMAGE/RPI satellite during the years 2000-2005 below the altitude of 5000 km. Approximately 2500 WM echoes have been observed by IMAGE during this period. This includes mostly specularly reflected whistler mode (SRWM) echoes and ~400 magnetospherically reflected whistler mode (MRWM) echoes. Stanford 2D raytracing simulations and the diffusive equilibrium density model have been applied to 82 cases of MRWM echoes, observed during August-December of the year 2005 below 5000 km to determine electron and ion density measurements along Earth's magnetic field line. These are the first results of electron and ion density measurements from WM sounding covering L-shells ~1.6-4, a wide range of geomagnetic conditions (Kp 0+ to 7), and during solar minima (F10.2~70-120) in the altitude range 90 km to 4000 km. The electron and ion density profiles obtained from this analysis were compared with in situ measurements on IMAGE (passive recording; electron density (Ne)), DMSP (~850 km; Ne and ions), CHAMP (~350 km; Ne), Alouette (~500-2000 km; Ne and ions), ISIS-1, 2 (~600-3500 km; Ne, ions), AE (~130-2000 km; ions) satellites, bottom side sounding from nearby ionosonde stations (Ne), and those by GCPM (Global Core Plasma Model), IRI-2012 (International Reference Ionosphere). Based on this analysis it is found that: (1) Ne shows a decreasing trend from L-shell 1.6 to 4 on both the day and night sides of the plasmasphere up to altitude ~1000 km, which is also confirmed by the GCPM and IRI-2012 model. (2) Above ~2000 km altitude, GCPM underestimates Ne by ~30-90% relative to RPI passive measurements, WM sounding results. (3) Below 1500 km, the Ne is higher at day side than night side MLT (Magnetic Local Time). Above this altitude, significant MLT dependence of electron density is not seen. (4) Ion densities from WM sounding measurements are within 10-35% of those from the Alouette, AE, and

  13. Unexpected characteristics of the 150 km echoes observed over Gadanki and their implications

    NASA Astrophysics Data System (ADS)

    Patra, A. K.; Pavan Chaitanya, P.

    2016-11-01

    Recent discovery of two distinct types of 150 km echoes, namely, type-A and type-B, and subsequent progress in the large-scale kinetic simulation of photoelectron-induced plasma waves have begun a new era in resolving the five decades long 150 km echoing riddle. In this paper, we present hitherto unrevealed three important and unexpected findings on the two distinct types of 150 km echoes based on Gadanki radar observations. Our observations show unexpected predominance of type-A echoes, strong seasonal dependence of both type-A and type-B echoes, and a surprising connection of the type-B echoes to the unusually deep solar minimum of 2008-2009. We discuss how these results provide important new clues in tethering the competing processes involved in the daytime 150 km echoes and have significance in the recently proposed photoelectron-induced plasma fluctuations as a potential mechanism for the 150 km echoes.

  14. Cape Canaveral, Florida range reference atmosphere 0-70 km altitude

    NASA Technical Reports Server (NTRS)

    Tingle, A. (Editor)

    1983-01-01

    The RRA contains tabulations for monthly and annual means, standard deviations, skewness coefficients for wind speed, pressure temperature, density, water vapor pressure, virtual temperature, dew-point temperature, and the means and standard deviations for the zonal and meridional wind components and the linear (product moment) correlation coefficient between the wind components. These statistical parameters are tabulated at the station elevation and at 1 km intervals from sea level to 30 km and at 2 km intervals from 30 to 90 km altitude. The wind statistics are given at approximately 10 m above the station elevations and at altitudes with respect to mean sea level thereafter. For those range sites without rocketsonde measurements, the RRAs terminate at 30 km altitude or they are extended, if required, when rocketsonde data from a nearby launch site are available. There are four sets of tables for each of the 12 monthly reference periods and the annual reference period.

  15. Design and mass production of the optical modules for KM3NeT-Italia project

    NASA Astrophysics Data System (ADS)

    Leonora, Emanuele; Aiello, Sebastiano; Giordano, Valentina

    2016-04-01

    The KM3NeT European project aims at constructing a km3 underwater neutrino telescope in the depths of the Mediterranean Sea. The first phase that is under construction will comprise eight tower-like detection structures (KM3NeT-Italia), which will form the internal core of a km3-scale detector. The detection element of KM3NeT-Italia, the optical module, is made of a 13-inch pressure-resistant glass-vessel that contains a single 10-inch photomultiplier and the relative electronics. The design of the whole optical module, the main results obtained from the massive photomultipliers measurements, and the foremost phases of the mass production procedure performed at the production site of Catania are also presented.

  16. Pure Rotational Raman Lidar for Temperature Measurements from 5-40 Km Over Wuhan, China

    NASA Astrophysics Data System (ADS)

    Li, Yajuan; Song, Shalei; Yang, Yong; Li, Faquan; Cheng, Xuewu; Chen, Zhenwei; Liu, Linmei; McCormick, M. Patrick; Gong, Shunsheng

    2016-06-01

    In this paper a pure rotational Raman lidar (PRR) was established for the atmospheric temperature measurements from 5 km to 40 km over Wuhan, China (30.5°N, 114.5°E). To extract the expected PRR signals and simultaneously suppress the elastically backscattered light, a high-spectral resolution polychromator for light splitting and filtering was designed. Observational results revealed that the temperature difference measured by PRR lidar and the local radiosonde below 30 km was less than 3.0 K. The good agreement validated the reliability of the PRR lidar. With the 1-h integration and 150-m spatial resolution, the statistical temperature error for PRR lidar increases from 0.4 K at 10 km up to 4 K at altitudes of about 30 km. In addition, the whole night temperature profiles were obtained for study of the long-term observation of atmospheric fluctuations.

  17. Bioavailability of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) to the Praire Vole (Microtus ochrogaster).

    SciTech Connect

    Fellows, Robert J.; Driver, Crystal J.; Cataldo, Dominic A.; Harvey, Scott D.

    2006-07-01

    Estimating risk to wildlife requires that measures of exposure be equivalent to that of the laboratory studies from which toxic responses were observed. Exposure measures are often based on modeled estimates of uptake through the food web. These modeled estimates use largely untested assumptions that can lead to inaccurate, uncertain, and unreliable estimates of exposure. Recently, concerns have been raised over the potential bioavailability and biotransfer of munitions or energetics materials such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is more recalcitrant in the soil, may remain as the parent compound for extended periods of time, and is rapidly taken up by the roots of higher plants and partitioned predominantly into the above ground, herbivore-accessible tissues. This study assessed plant incorporated [14C]-RDX and plant derived [14C]-RDX-metabolites ingestion by a representative hindgut herbivore, the prairie vole (Microtus ochrogaster). The animals were fed the labeled chow (≤10 g/ day max) for five or seven days followed by a six or four day chase period with the control chow prior to final weighing and sacrifice. Animal excreta including feces, urine, and respired CO2 were collected and measured. Greater than 95% of all label presented to the voles was recovered in the summed excreta. Seventy-four percent of the label in the total excreta was found in the fecal non-absorbed bulk. This means that greater than 20% of the presented 14C-RDX and plant-derived 14C-RDX-metabolites were absorbed by the animal’s digestive tracts over the time course of the experiment and modified prior to release. These materials were either metabolized to 14CO2 (8 to 10% of the total label) or removed as nitrogenous waste through the kidneys (10 to 14%). The feeding regimes were followed by a rapid, 2 to 3 day, clearing of label from the bulk feces with the cessation of exposure. Both 14C-urine and 14CO2 excretion continued after the feces cleared indicating

  18. A 1.3 cm line survey toward Orion KL

    NASA Astrophysics Data System (ADS)

    Gong, Y.; Henkel, C.; Thorwirth, S.; Spezzano, S.; Menten, K. M.; Walmsley, C. M.; Wyrowski, F.; Mao, R. Q.; Klein, B.

    2015-09-01

    Context. The nearby Orion Kleinmann-Low nebula is one of the most prolific sources of molecular line emission. It has served as a benchmark for spectral line searches throughout the (sub)millimeter regime. Aims: The main goal is to systematically study the spectral characteristics of Orion KL in the λ ~ 1.3 cm band. Methods: We carried out a spectral line survey with the Effelsberg-100 m telescope toward Orion KL. It covers the frequency range between 17.9 GHz and 26.2 GHz, i.e., the radio "K band". We also examined ALMA maps to address the spatial origin of molecules detected by our 1.3 cm line survey. Results: In Orion KL, we find 261 spectral lines, yielding an average line density of about 32 spectral features per GHz above 3σ (a typical value of 3σ is 15 mJy). The identified lines include 164 radio recombination lines (RRLs) and 97 molecular lines. The RRLs, from hydrogen, helium, and carbon, stem from the ionized material of the Orion Nebula, part of which is covered by our beam. The molecular lines are assigned to 13 different molecular species including rare isotopologues. A total of 23 molecular transitions from species known to exist in Orion KL are detected for the first time in the interstellar medium. Non-metastable (J>K) 15NH3 transitions are detected in Orion KL for the first time. Based on the velocity information of detected lines and the ALMA images, the spatial origins of molecular emission are constrained and discussed. A narrow feature is found in SO2 (81,7 - 72,6), but not in other SO2 transitions, possibly suggesting the presence of a maser line. Column densities and fractional abundances relative to H2 are estimated for 12 molecules with local thermodynamic equilibrium (LTE) methods. Rotational diagrams of non-metastable 14NH3 transitions with J = K + 1 to J = K + 4 yield different results; metastable (J = K) 15NH3 is found to have a higher excitation temperature than non-metastable 15NH3, also indicating that they may trace different

  19. Modular, Concise, and Efficient Synthesis of Highly Functionalized 5-Fluoropyridazines by a [2 + 1]/[3 + 2]-Cycloaddition Sequence.

    PubMed

    Tran, Gaël; Gomez Pardo, Domingo; Tsuchiya, Tomoki; Hillebrand, Stefan; Vors, Jean-Pierre; Cossy, Janine

    2015-07-17

    An easy access to 5-fluoropyridazines by a [2 + 1]/[3 + 2]-cycloaddition sequence between terminal alkynes, a difluorocarbene, and a diazo compound is reported. This approach does not necessitate the isolation of any intermediates, and a wide range of novel 5-fluoropyridazines was synthesized from readily available starting materials. Additionally, these compounds were used as a platform to access novel and highly diversified pyridazines.

  20. Temperature-dependent photochemistry of 1,3-diphenylpropenes. The di-pi-methane reaction revisited.

    PubMed

    Lewis, F D; Zuo, X; Kalgutkar, R S; Wagner-Brennan, J M; Miranda, M A; Font-Sanchis, E; Perez-Prieto, J

    2001-12-05

    The temperature-dependent photochemical behavior of 1,3-diphenylpropene and several of its 3-substituted derivatives has been investigated over a wide temperature range. The singlet state is found to decay via two unactivated processes, fluorescence and intersystem crossing, and two activated processes, trans,cis isomerization and phenyl-vinyl bridging. The latter activated process yields a diradical intermediate which partitions between ground-state reactant and formation of the di-pi-methane rearrangement product. Kinetic modeling of temperature-dependent singlet decay times and quantum yields of fluorescence, isomerization, di-pi-methane rearrangement, and nonradiative decay provides rate constants and activation parameters for each of the primary and secondary processes. Substituents at the 3-position are found to have little effect on the electronic spectra or unactivated fluorescence and intersystem crossing pathways. However, they do effect the activated primary and secondary processes. Thus, the product ratios are highly temperature dependent.

  1. 1,3-Butadiene: linking metabolism, dosimetry, and mutation induction.

    PubMed Central

    Bond, J A; Csanady, G A; Gargas, M L; Guengerich, F P; Leavens, T; Medinsky, M A; Recio, L

    1994-01-01

    There is increasing concern for the potential adverse health effects of human exposures to chemical mixtures. To better understand the complex interactions of chemicals within a mixture, it is essential to develop a research strategy which provides the basis for extrapolating data from single chemicals to their behavior within the chemical mixture. 1,3-Butadiene (BD) represents an interesting case study in which new data are emerging that are critical for understanding interspecies differences in carcinogenic/genotoxic response to BD. Knowledge regarding mechanisms of BD-induced carcinogenicity provides the basis for assessing the potential effects of mixtures containing BD. BD is a multisite carcinogen in B6C3F1 mice and Sprague-Dawley rats. Mice exhibit high sensitivity relative to the rat to BD-induced tumorigenesis. Since it is likely that BD requires metabolic activation to mutagenic reactive epoxides that ultimately play a role in carcinogenicity of the chemical, a quantitative understanding of the balance of activation and inactivation is essential for improving our understanding and assessment of human risk following exposure to BD and chemical mixtures containing BD. Transgenic mice exposed to 625 ppm BD for 6 hr/day for 5 days exhibited significant mutagenicity in the lung, a target organ for the carcinogenic effect of BD in mice. In vitro studies designed to assess interspecies differences in the activation of BD and inactivation of BD epoxides reveal that significant differences exist among mice, rats, and humans. In general, the overall activation/detoxication ratio for BD metabolism was approximately 10-fold higher in mice compared to rats or humans.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7698092

  2. Optical Design of WFIRST-AFTA Wide-Field Instrument

    NASA Technical Reports Server (NTRS)

    Pasquale, Bert; Content, Dave; Kruk, Jeffrey; Vaughn, David; Gong, Qian; Howard, Joseph; Jurling, Alden; Mentzell, Eric; Armani, Nerses; Kuan, Gary

    2014-01-01

    The WFIRSTAFTA Wide-Field Infrared Survey Telescope TMA optical design provides 0.28-sq FOV at 0.11 pixel scale, operating between 0.6 2.4m, including a spectrograph mode (1.3-1.95m.) An IFU provides a discrete 3x3.15 field at 0.15 sampling.

  3. Listening to music in the first, but not the last 1.5 km of a 5-km running trial alters pacing strategy and improves performance.

    PubMed

    Lima-Silva, A E; Silva-Cavalcante, M D; Pires, F O; Bertuzzi, R; Oliveira, R S F; Bishop, D

    2012-10-01

    We examined the effects of listening to music on attentional focus, rating of perceived exertion (RPE), pacing strategy and performance during a simulated 5-km running race. 15 participants performed 2 controlled trials to establish their best baseline time, followed by 2 counterbalanced experimental trials during which they listened to music during the first (M start) or the last (M finish) 1.5 km. The mean running velocity during the first 1.5 km was significantly higher in M start than in the fastest control condition (p<0.05), but there was no difference in velocity between conditions during the last 1.5 km (p>0.05). The faster first 1.5 m in M start was accompanied by a reduction in associative thoughts compared with the fastest control condition. There were no significant differences in RPE between conditions (p>0.05). These results suggest that listening to music at the beginning of a trial may draw the attentional focus away from internal sensations of fatigue to thoughts about the external environment. However, along with the reduction in associative thoughts and the increase in running velocity while listening to music, the RPE increased linearly and similarly under all conditions, suggesting that the change in velocity throughout the race may be to maintain the same rate of RPE increase.

  4. Crustal structure of the Morrocan margin from wide-angle and reflection seismic data

    NASA Astrophysics Data System (ADS)

    Aslanian, D.; Klingelhoefer, F.; Labails, C.; Cosquer, E.; Geli, L.; Olivet, J.; Sahabi, M.; Nouze, H.; Rouzo, S.; Unternehr, P.

    2004-12-01

    Two deep seismic cruises were conducted as joint projects between Ifremer, Total, and the Universities of Brest, El Jadida and Lisbon to constrain the deep crustal structure of the Morrocan continental margin. During the SISMAR cruise four combined wide-angle and reflection seismic profiles were acquired on the northern Morrocan passive margin. Two profiles were shot parallel and two profiles perpendicular to the margin. During the DAKHLA cruise, a total 1500 km of seismic reflection and wide-angle profiles were acquired off the southern Morrocan margin. Modelling of the reflection and wide-angle seismic data from the SISMAR survey images the thick sedimentary cover of the margin, which is locally perturbed by salt tectonics. The sedimentary basin thickens from 1.5 km on normal oceanic crust to a maximum thickness of 6 km at the base of the continental slope. The model reveals basement structures including a few tilted fault blocks and a transition zone to thin oceanic-type crust. The crust thins from 35 km underneath the continent to about 7 km at the western end of the profile. Modelling of the seismic data from the DAKHLA cruise reveals a 10 km deep sedimentary basin including two high velocity carbonate layers. The crustal thinning from 30 km at the continental part to 7 km in the oceanic part occurs over a 100 km wide zone. Oceanic crust east of the M25 magnetic anomaly displays higher velocities in layer 3 than west of the magnetic anomaly. This change in velocity suggests a possible link to changes in accretionary processes of the oceanic crust. A comparison of wide-angle models from the northern and southern experiment show similar continental crustal thickness and structure in both regions, but a wider ocean - continent transition zone in the south. No high velocity layer corresponding to either serpentinized upper mantle or underplating has been imaged in either margin transect.

  5. Crustal structure of the Morrocan margin from wide-angle and reflection seismic data

    NASA Astrophysics Data System (ADS)

    Aslanian, D.; Klingelhoefer, F.; Labails, C.; Cosquer, E.; Geli, L.; Olivet, J.; Sahabi, M.; Nouze, H.; Rouzo, S.; Unternehr, P.

    2007-12-01

    Two deep seismic cruises were conducted as joint projects between Ifremer, Total, and the Universities of Brest, El Jadida and Lisbon to constrain the deep crustal structure of the Morrocan continental margin. During the SISMAR cruise four combined wide-angle and reflection seismic profiles were acquired on the northern Morrocan passive margin. Two profiles were shot parallel and two profiles perpendicular to the margin. During the DAKHLA cruise, a total 1500 km of seismic reflection and wide-angle profiles were acquired off the southern Morrocan margin. Modelling of the reflection and wide-angle seismic data from the SISMAR survey images the thick sedimentary cover of the margin, which is locally perturbed by salt tectonics. The sedimentary basin thickens from 1.5 km on normal oceanic crust to a maximum thickness of 6 km at the base of the continental slope. The model reveals basement structures including a few tilted fault blocks and a transition zone to thin oceanic-type crust. The crust thins from 35 km underneath the continent to about 7 km at the western end of the profile. Modelling of the seismic data from the DAKHLA cruise reveals a 10 km deep sedimentary basin including two high velocity carbonate layers. The crustal thinning from 30 km at the continental part to 7 km in the oceanic part occurs over a 100 km wide zone. Oceanic crust east of the M25 magnetic anomaly displays higher velocities in layer 3 than west of the magnetic anomaly. This change in velocity suggests a possible link to changes in accretionary processes of the oceanic crust. A comparison of wide-angle models from the northern and southern experiment show similar continental crustal thickness and structure in both regions, but a wider ocean - continent transition zone in the south. No high velocity layer corresponding to either serpentinized upper mantle or underplating has been imaged in either margin transect.

  6. Spectral and nonlinear optical studies of Propane-1, 3-diaminium nitrate

    NASA Astrophysics Data System (ADS)

    Ayadi, R.; Lhoste, J.; Ngo, H. M.; Ledoux-Rak, I.; Mhiri, T.; Boujelbene, M.

    2016-08-01

    Propane-1, 3-diaminium nitrate [C3H12N2] (NO3)2 (PDAN), an hybrid organic-inorganic nonlinear optical material combining an acentric octupolar moiety (nitrate) with a centrosymmetric organic molecule (Propane-1, 3-diaminium) was prepared by slow evaporation technique at room temperature from its aqueous solution. Good quality and well-developed crystals of size 0.133 mm×0.092 mm×0.078 mm were harvested from the mother solution. The grown single crystals were characterized for their spectral, thermal, linear and second order nonlinear optical properties. Solid-state 13C and 1H MAS-NMR spectroscopies are in agreement with the X-ray structure. The decomposition of the title compound is confirmed by the thermogravimetric analysis (TGA). The UV-visible absorption spectrum, show that PDAN is suitable for frequency doubling applications in a wide spectral range in the visible and near IR. The NLO response of the crystal was evaluated using a SHG powder technique, indicating an effective quadratic nonlinear coefficient two times higher than that of KDP in spite of the low hyperpolarizability of the nitrate ion and of the centrosymmetric character of the diaminium derivative.

  7. Global Investigation of the Mg Atom and ion Layers using SCIAMACHY/Envisat Observations between 70 km and 150 km Altitude and WACCM-MG Model Results

    NASA Technical Reports Server (NTRS)

    Langowski, M.; vonSavigny, C.; Burrows, J. P.; Feng, W.; Plane, J. M. C.; Marsh, D. R.; Janches, Diego; Sinnhuber, M.; Aikin, A. C.

    2014-01-01

    Mg and Mg+ concentration fields in the upper mesosphere/lower thermosphere (UMLT) region are retrieved from SCIAMACHY/Envisat limb measurements of Mg and Mg+ dayglow emissions using a 2-D tomographic retrieval approach. The time series of monthly means of Mg and Mg+ for number density as well as vertical column density in different latitudinal regions are shown. Data from the limb mesosphere-thermosphere mode of SCIAMACHY/Envisat are used, which covers the 50 km to 150 km altitude region with a vertical sampling of 3.3 km and a highest latitude of 82 deg. The high latitudes are not covered in the winter months, because there is no dayglow emission during polar night. The measurements were performed every 14 days from mid-2008 until April 2012. Mg profiles show a peak at around 90 km altitude with a density between 750 cm(exp-3) and 2000 cm(exp-3). Mg does not show strong seasonal variation at mid-latitudes. The Mg+ peak occurs 5-15 km above the neutral Mg peak at 95-105 km. Furthermore, the ions show a significant seasonal cycle with a summer maximum in both hemispheres at mid- and high-latitudes. The strongest seasonal variations of the ions are observed at mid-latitudes between 20-40 deg and densities at the peak altitude range from 500 cm(exp-3) to 6000 cm(exp-3). The peak altitude of the ions shows a latitudinal dependence with a maximum at mid-latitudes that is up to 10 km higher than the peak altitude at the equator. The SCIAMACHY measurements are compared to other measurements and WACCM model results. In contrast to the SCIAMACHY results, the WACCM results show a strong seasonal variability for Mg with a winter maximum, which is not observable by SCIAMACHY, and globally higher peak densities. Although the peak densities do not agree the vertical column densities agree, since SCIAMACHY results show a wider vertical profile. The agreement of SCIAMACHY and WACCM results is much better for Mg+, showing the same seasonality and similar peak densities. However

  8. Benzene-1,3,5-tri-carb-oxy-lic acid-pyridinium-2-olate (1/3).

    PubMed

    Campos-Gaxiola, José J; Zamora Falcon, Felipe; Corral Higuera, Ramón; Höpfl, Herbert; Cruz-Enríquez, Adriana

    2014-04-01

    The asymmetric unit of the title compound, C9H6O6·3C5H5NO, contains one benzene-1,3,5-tri-carb-oxy-lic acid mol-ecule (BTA) and three pyridin-2-ol mol-ecules each present in the zwitterion form. In the crystal, these entities are linked through O-H⋯O(-) and N(+)-H⋯O(-) hydrogen bonds, forming sheets parallel to (10-1). These layers contain macrocyclic rings of composition [BTA]2[pyol]6 and with graph-set notation R (6) 8(44), which are stacked along c through π-π inter-actions [inter-centroid distances = 3.536 (2)-3.948 (3) Å]. They are inter-connected by N(+)-H⋯O(-) hydrogen-bonded chains of pyridin-2-ol mol-ecules running parallel to c, forming a three-dimensional network. There are also C-H⋯O hydrogen bonds present which reinforce the three-dimensional structure.

  9. The effects of running a 308 km ultra-marathon on cardiac markers.

    PubMed

    Kim, Young-Joo; Shin, Young-Oh; Lee, Jeong-Beom; Lee, Yoon-Hee; Shin, Kyung-A; Kim, Al-Chan; Goh, Choong-Won; Kim, Chul; Oh, Jae-Keun; Min, Young-Ki; Yang, Hun-Mo

    2014-01-01

    The aim of this study was to investigate the expression of cardiac strain and damage in 18 male marathoners with average age of 52.8 ± 5.0 years running at a 308 km ultra-marathon. Blood samples were collected at pre-race, 100 km, 200 km and 308 km check points for the analysis of cardiac muscle injury markers, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), cardiac troponin I (cTnI) and cardiac muscle strain marker, N-terminal pro-brain natriuretic peptide (NT-proBNP). The CK levels increased 1127.2 ± 507.9 IU/L, 5133.8 ± 2492.7 IU/L and 4958.4 ± 2087.9 IU/L at 100 km, 200 km and 308 km, respectively, compared to the pre-race levels. The CK-MB levels increased 20.2 ± 11.2 ng/mL, 73.3 ± 35.6 ng/mL and 68.6 ± 42.6 ng/mL at 100, 200 and 308 km, respectively, compared to the pre-race levels. The CK-MB/CK ratio showed that the CK-MB mass index was within the normal range (<2.5%) at 100 km, 200 km and 308 km. The cTnI levels showed no significant difference in all check points. The NT-proBNP levels increased 146.55 ± 92.7 pg/mL, 167.95 ± 111.9 pg/mL and 241.23 ± 121.2 pg/mL at 100, 200 and 308 km, respectively, compared to the pre-race levels. The normal CK-MB mass index (<5.0 ng/mL) and the absence of an increase in the cTnI levels during the 308 km ultra-marathon suggested that no myocardial injury despite an elevation in CK-MB. The increase in NT-proBNP levels probably resulted from continuous hemodynamic cardiac stress and represents a transient physiological myocardial protective response.

  10. Synthesis and photochemical properties of 1,3-di-9-anthryl-2-propanol, 1,3-di-9-anthrylacetone, and related propano-linked anthracenes

    SciTech Connect

    Becker, H.D.; Amin, K.A. )

    1989-06-23

    9-anthryllithium reacts with epichlorohydrin to give 1,3-di-9-anthryl-2-propanol via 3-(9-anthryl)-1-chloro-2-hydroxypropane and 3-(9-anthryl)-1,2-epoxypropane. Oxidation of dianthryl-2-propanol with Dess-Martin reagent gave 1,3-di-9-anthrylacetone. Various other 1,3-bichromophoric anthracenes were synthesized by way of C-methylation of dianthrylacetone, 1,3-di-9-anthryl-1-propanone, and 1,3-di-9-anthrylpropenone. 9-Anthrylacetone, formed as byproduct in the reaction of anthryllithium with epichlorohydrin, was prepared from 9-anthrylacetaldehyde by Grignard reaction with methylmagnesium iodide and subsequent oxidation. The excited-state properties of dianthryl-2-propanol, dianthrylacetone, 1,3-di-9-anthryl-2-methyl-1-propanone, 1,3-di-9-anthryl-2-methyl-2-propanol, diastereomeric 1,3-di-9-anthryl-1-butanols, 1,3-di-9-anthryl-2-butanone, 1,3-di-9-anthryl-1-butanone, and diastereomeric 1,3-di-9-anthryl-2-methyl-1-butanones have been evaluated by fluorescence quantum yields, and by quantum yields for the isomerization by intramolecular 4{pi} + 4{pi} cycloaddition. Dianthryl-2-propanol, 1,3-di-9-antrhyl-2-methyl-2-propanol, dianthrylacetone, diastereomeric 1,3-di-9-anthryl-1-butanols, and 1,3-di-9-anthryl-2-butanone isomerize in their excited singlet state with quantum yields of 0.046, 0.021, 0.25, 0.23, and 0.22, respectively. The photochemical isomerization of those 1,3-bichromophoric anthrancenes which are characterized by a 9-anthroyl chromophore involves the excited triplet state, and the cyclization quantum yield may be as high as 0.72.

  11. In silico analysis of β-1,3-glucanase from a psychrophilic yeast, Glaciozyma antarctica PI12

    NASA Astrophysics Data System (ADS)

    Mohammadi, Salimeh; Bakar, Farah Diba Abu; Rabu, Amir; Murad, Abdul Munir Abdul

    2014-09-01

    1,3-beta-glucanase is an industrially important enzyme having wide range of applications especially in food industry. It is crucial to gain an understanding about the structure and functional aspects of various beta-1,3-glucanase produced from diverse sources. In this, study a cDNA encoding β-1,3-glucanase (GaExg55) was isolated from a psychrophilic yeast, Glaciozyma antarctica PI12. The cDNA sequence has been submitted to Genbank with an accession number (KJ436377). Subsequently, the perdition protein was analyzed using various bioinformatics tools to explore the properties of the protein. GaEXG55 is consisting of 1,440-bp nucleotides encoding 480 amino acid residues. Alignment of the deduced amino acid for GaExg55 with other exo-β-1,3-glucanase available at the NCBI database indicate that deduced amino acids shared a consensus motif NEP, which is signature pattern of GH5 hydrolases. Predicted molecular weight of GaExg55 is 53.66 kDa. GaExg55 sequences possesses signal peptide sequence and it is highly conserved with other fungal exo-beta-1,3 glucanase.

  12. Alkyltransferase-mediated Toxicity of 1,3-Butadiene Diepoxide

    PubMed Central

    Kalapila, Aley G.; Loktionova, Natalia A.; Pegg, Anthony E.

    2008-01-01

    Human O6-alkylguanine-DNA alkyltransferase (hAGT) expression increases mutations and cytotoxicity following exposure to 1,3-butadiene diepoxide (BDO) and hAGT-DNA cross-links are formed in the presence of BDO. We have used hAGT mutants to investigate the mechanism of cross-link formation and genotoxicity. Formation of a hAGT-DNA conjugate in vitro was observed with C145S and C145A mutant proteins but was considerably diminished with the C145A/C150S double mutant confirming that cross-linking primarily involves either of these two cysteine residues, which are located in the active site pocket of the protein. Cross-link formation by BDO occurred both via (a) an initial reaction of BDO with hAGT followed by attack of the reactive hAGT complex on DNA, and (b) the initial reaction of BDO with DNA followed by a reaction between hAGT and the DNA adduct. These results differ from those with 1,2-dibromoethane (DBE) where Cys145 is the only site of attachment and pathway (b) does not occur. The complex formed between hAGT at Cys145 and BDO was very unstable in aqueous solution. However, the BDO-hAGT complex at Cys150 exhibited stability for more than 1 h. The effect of hAGT and mutants on BDO-induced genotoxicity was studied in E. coli using the forward assay to rifampicin resistance. Both mutations and cell killing were greatly increased by wild type hAGT and there was a smaller but significant effect with the C145A mutant. The R128A mutant and R128A/C145A and C145A/C150S double mutants were ineffective supporting the hypothesis that the formation of hAGT-DNA cross-links is responsible for the enhanced genotoxicity detected in this biological system. In the absence of hAGT, there were equal proportions of G:C to A:T transitions, G:C to T:A transversions and A:T to T:A transversions. Wild type hAGT expression yielded significantly greater G:C to A:T and A:T to G:C transitions, whereas C145A mutant expression resulted in more transitions and transversions at A:T base

  13. Quantitation of DNA Adducts Induced by 1,3-Butadiene

    NASA Astrophysics Data System (ADS)

    Sangaraju, Dewakar; Villalta, Peter W.; Wickramaratne, Susith; Swenberg, James; Tretyakova, Natalia

    2014-07-01

    Human exposure to 1,3-butadiene (BD) present in automobile exhaust, cigarette smoke, and forest fires is of great concern because of its potent carcinogenicity. The adverse health effects of BD are mediated by its epoxide metabolites such as 3,4-epoxy-1-butene (EB), which covalently modify genomic DNA to form promutagenic nucleobase adducts. Because of their direct role in cancer, BD-DNA adducts can be used as mechanism-based biomarkers of BD exposure. In the present work, a mass spectrometry-based methodology was developed for accurate, sensitive, and precise quantification of EB-induced N-7-(1-hydroxy-3-buten-2-yl) guanine (EB-GII) DNA adducts in vivo. In our approach, EB-GII adducts are selectively released from DNA backbone by neutral thermal hydrolysis, followed by ultrafiltration, offline HPLC purification, and isotope dilution nanoLC/ESI+-HRMS3 analysis on an Orbitrap Velos mass spectrometer. Following method validation, EB-GII lesions were quantified in human fibrosarcoma (HT1080) cells treated with micromolar concentrations of EB and in liver tissues of rats exposed to sub-ppm concentrations of BD (0.5-1.5 ppm). EB-GII concentrations increased linearly from 1.15 ± 0.23 to 10.11 ± 0.45 adducts per 106 nucleotides in HT1080 cells treated with 0.5-10 μM DEB. EB-GII concentrations in DNA of laboratory rats exposed to 0.5, 1.0, and 1.5 ppm BD were 0.17 ± 0.05, 0.33 ± 0.08, and 0.50 ± 0.04 adducts per 106 nucleotides, respectively. We also used the new method to determine the in vivo half-life of EB-GII adducts in rat liver DNA (2.20 ± 0.12 d) and to detect EB-GII in human blood DNA. To our knowledge, this is the first application of nanoLC/ESI+-HRMS3 Orbitrap methodology to quantitative analysis of DNA adducts in vivo.

  14. Marshall Space Flight Center Propulsion Systems Department (PSD) Knowledge Management (KM) Initiative

    NASA Technical Reports Server (NTRS)

    Caraccioli, Paul; Varnedoe, Tom; Smith, Randy; McCarter, Mike; Wilson, Barry; Porter, Richard

    2006-01-01

    NASA Marshall Space Flight Center's Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities within the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center of Excellence (AISCE), lntergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KNI implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to suppoth e planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have beon pedormed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural1KM surveys and practitioner interviews include

  15. An Efficient Synthesis of Bis-indolylindane-1,3-diones, Indan-1,3-diones, and Indene-1,3(2H)-denies Using [Hbim]BF4 Ionic Medium

    PubMed Central

    Poor Heravi, Mohammad Reza

    2013-01-01

    We prepared a brand new molecule in one step for the synthesis of bis-indolylindane-1,3-dione and indan-1,3-diones from the reaction of ninhydrin and 3 substituted/unsubstituted indoles using [Hbim]BF4 ionic liquid in excellent yields. The method was also used for the synthesis of novel indene-1,3(2H)-denies derivatives. PMID:24455297

  16. A novel process for recycling and resynthesizing LiNi1/3Co1/3Mn1/3O2 from the cathode scraps intended for lithium-ion batteries.

    PubMed

    Zhang, Xihua; Xie, Yongbing; Cao, Hongbin; Nawaz, Faheem; Zhang, Yi

    2014-09-01

    To solve the recycling challenge for aqueous binder based lithium-ion batteries (LIBs), a novel process for recycling and resynthesizing LiNi1/3Co1/3Mn1/3O2 from the cathode scraps generated during manufacturing process is proposed in this study. Trifluoroacetic acid (TFA) is employed to separate the cathode material from the aluminum foil. The effects of TFA concentration, liquid/solid (L/S) ratio, reaction temperature and time on the separation efficiencies of the cathode material and aluminum foil are investigated systematically. The cathode material can be separated completely under the optimal experimental condition of 15vol.% TFA solution, L/S ratio of 8.0 mL g(-1), reacting at 40°C for 180 min along with appropriate agitation. LiNi1/3Co1/3Mn1/3O2 is successfully resynthesized from the separated cathode material by solid state reaction method. Several kinds of characterizations are performed to verify the typical properties of the resynthesized LiNi1/3Co1/3Mn1/3O2 powder. Electrochemical tests show that the initial charge and discharge capacities of the resynthesized LiNi1/3Co1/3Mn1/3O2 are 201 mAh g(-)(1) and 155.4 mAh g(-1) (2.8-4.5 V, 0.1C), respectively. The discharge capacity remains at 129 mAh g(-1) even after 30 cycles with a capacity retention ratio of 83.01%.

  17. Synthesis of new visible light active photocatalysts of Ba(In(1/3)Pb(1/3)M'(1/3))O3 (M' = Nb, Ta): a band gap engineering strategy based on electronegativity of a metal component.

    PubMed

    Hur, Su Gil; Kim, Tae Woo; Hwang, Seong-Ju; Park, Hyunwoong; Choi, Wonyong; Kim, Sung Jin; Kim, Sun Jin; Choy, Jin-Ho

    2005-08-11

    We have synthesized new, efficient, visible light active photocatalysts through the incorporation of highly electronegative non-transition metal Pb or Sn ions into the perovskite lattice of Ba(In(1/3)Pb(1/3)M'(1/3))O3 (M = Sn, Pb; M' = Nb, Ta). X-ray diffraction, X-ray absorption spectroscopic, and energy dispersive spectroscopic microprobe analyses reveal that tetravalent Pb or Sn ions exist in the B-site of the perovskite lattice, along with In and Nb/Ta ions. According to diffuse UV-vis spectroscopic analysis, the Pb-containing quaternary metal oxides Ba(In(1/3)Pb(1/3)M'(1/3))O3 possess a much narrower band gap (E(g) approximately 1.48-1.50 eV) when compared to the ternary oxides Ba(In(1/2)M'(1/2))O3 (E(g) approximately 2.97-3.30 eV) and the Sn-containing Ba(In(1/3)Sn(1/3)M'(1/3))O3 derivatives (E(g) approximately 2.85-3.00 eV). Such a variation of band gap energy upon the substitution is attributable to the broadening of the conduction band caused by the dissimilar electronegativities of the B-site cations. In contrast to the ternary or the Sn-substituted quaternary compounds showing photocatalytic activity under UV-vis irradiation, the Ba(In(1/3)Pb(1/3)M'(1/3))O3 compounds induce an efficient photodegradation of 4-chlorophenol under visible light irradiation (lambda > 420 nm). The present results highlight that the substitution of electronegative non-transition metal cations can provide a very powerful way of developing efficient visible light harvesting photocatalysts through tuning of the band structure of a semiconductive metal oxide.

  18. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents.

    PubMed

    Rezki, Nadjet; Al-Yahyawi, Amjad M; Bardaweel, Sanaa K; Al-Blewi, Fawzia F; Aouad, Mohamed R

    2015-09-02

    In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, ¹H-NMR, (13)C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.

  19. High-voltage performance of LiNi1/3Co1/3Mn1/3O2/graphite batteries with di(methylsulfonyl) methane as a new sulfone-based electrolyte additive

    NASA Astrophysics Data System (ADS)

    Zheng, Xiangzhen; Huang, Tao; Pan, Ying; Wang, Wenguo; Fang, Guihuang; Wu, Maoxiang

    2015-10-01

    In order to overcome the capacity fading of LiNi1/3Co1/3Mn1/3O2/graphite lithium-ion batteries (LIBs) cycled in the voltage range of 3.0-4.6 V (vs. Li/Li+), di(methylsulfonyl) methane (DMSM) is evaluated as a new electrolyte additive. This study demonstrated that DMSM additive in the electrolyte can dramatically improve the cycling performance of LiNi1/3Co1/3Mn1/3O2/graphite cell at a higher voltage operation. In addition, the effects of this additive are characterized by linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), as well as transmission electron microscopy (TEM). With the addition of 0.1 wt. % DMSM into the electrolyte, the capacity loss of the LiNi1/3Co1/3Mn1/3O2/graphite cell cycled at the voltage range of 3.0-4.6 V significantly decreased from 39.0 % to 19.9 % after 100 cycles, which shows the promising application of DMSM at higher voltage. The enhanced cycling performance is attributed to the thinner cathode electrolyte interface film originated from DMSM on the LiNi1/3Co1/3Mn1/3O2, which not only resulted in lower interfacial impedance, but also protected the decomposition of electrolyte and prevented the cathode transition metal dissolution at the high voltage.

  20. The KM3Net project: A neutrino telescope in the depths of the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Di Capua, F.; KM3NeT Collaboration

    2016-01-01

    The KM3NeT Collaboration has started the first phase of construction of a next generation high-energy neutrino telescope in the Mediterranean Sea. With several cubic kilometers instrumented and thousand of optical sensors, KM3NeT will be the largest and most sensitive high-energy neutrino telescope. Thanks to its location in the Northern hemisphere and to its large instrumented volume KM3NeT will be the optimal instrument to search for neutrinos from the Southern sky and in particular from the Galactic plane, thus making it complementary to IceCube. The full KM3NeT detector will be a distributed, networked infrastructure comprising several detector blocks. In Italy, off the coast of Capo Passero, and in France, off the coast of Toulon, the construction of the KM3NeT-It and KM3NeT-Fr infrastructures respectively is in progress. In this work the technologically innovative component of the detector, the status of construction and the first results from prototypes of the KM3NeT detector will be described and its capability to discover neutrino sources is reported as well.

  1. [Comparative studies on monoclonal antibody KM10 and anti-CEA monoclonal antibodies].

    PubMed

    Soyama, N; Yamamoto, M; Ohyanagi, H; Saitoh, Y

    1989-11-01

    The specificity of KM10 was evaluated in comparison with newly developed anti-CEA monoclonal antibodies (A10, B9, JA4, AH3). Both KM10 and all anti-CEA monoclonal antibodies reacted with CEA in ELISA system, and with adenocarcinoma of the stomach, colon, and pancreas in the immunohistochemical assay. B9, JA4, and AH3 were suggested to react with CEA related antigens, such as NCA and BGPI, whereas KM10 and A10 were suggested to recognize the distinctive part of CEA. The antigenic determinant of CEA reactive with KM10 and A10 was revealed to be protein moiety after enzyme treatment. The competitive binding inhibition assay, however, indicated that epitopes of KM10 and A10 were different each other. Enzyme immunoassay using both KM10 and A10 could detect CEA. These findings showed the possible use of both KM10 and A10 for clinical diagnosis and treatment by means of targeting for the distinctive part of CEA.

  2. Action of an endo-β-1,3(4)-glucanase on cellobiosyl unit structure in barley β-1,3:1,4-glucan

    PubMed Central

    Kuge, Takao; Nagoya, Hiroki; Tryfona, Theodora; Kurokawa, Tsunemi; Yoshimi, Yoshihisa; Dohmae, Naoshi; Tsubaki, Kazufumi; Dupree, Paul; Tsumuraya, Yoichi; Kotake, Toshihisa

    2015-01-01

    β-1,3:1,4-Glucan is a major cell wall component accumulating in endosperm and young tissues in grasses. The mixed linkage glucan is a linear polysaccharide mainly consisting of cellotriosyl and cellotetraosyl units linked through single β-1,3-glucosidic linkages, but it also contains minor structures such as cellobiosyl units. In this study, we examined the action of an endo-β-1,3(4)-glucanase from Trichoderma sp. on a minor structure in barley β-1,3:1,4-glucan. To find the minor structure on which the endo-β-1,3(4)-glucanase acts, we prepared oligosaccharides from barley β-1,3:1,4-glucan by endo-β-1,4-glucanase digestion followed by purification by gel permeation and paper chromatography. The endo-β-1,3(4)-glucanase appeared to hydrolyze an oligosaccharide with degree of polymerization 5, designated C5-b. Based on matrix-assisted laser desorption/ionization (MALDI) time-of-flight (ToF)/ToF-mass spectrometry (MS)/MS analysis, C5-b was identified as β-Glc-1,3-β-Glc-1,4-β-Glc-1,3-β-Glc-1,4-Glc including a cellobiosyl unit. The results indicate that a type of endo-β-1,3(4)-glucanase acts on the cellobiosyl units of barley β-1,3:1,4-glucan in an endo-manner. PMID:26027730

  3. 3, 3‧-sulfonyldipropionitrile: A novel electrolyte additive that can augment the high-voltage performance of LiNi1/3Co1/3Mn1/3O2/graphite batteries

    NASA Astrophysics Data System (ADS)

    Zheng, Xiangzhen; Huang, Tao; Pan, Ying; Wang, Wenguo; Fang, Guihuang; Ding, Kaining; Wu, Maoxiang

    2016-07-01

    Our study shows that 3, 3‧-sulfonyldipropionitrile (SDPN), as an electrolyte additive, can dramatically enhance the performance of LiNi1/3Co1/3Mn1/3O2/graphite lithium-ion batteries (LIBs) at high voltages (3.0-4.6 V vs. Li/Li+). After adding 0.2 wt% SDPN to the electrolytes; i.-e., 1.0 M LiPF6-EC/DMC/EMC, the capacity for the LiNi1/3Co1/3Mn1/3O2/graphite cell to retain power was significantly increased from 59.5% to 77.3% after only 100 cycles, which shows the promising application of SDPN at higher voltages. Density functional theory calculation results indicate that SDPN had reduced oxidative constancy compared to ethylene carbonate (EC), dimethyl carbonate (DMC) and ethyl methyl carbonate (EMC). The effects of SDPN on cell performance are characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), electrochemical impedance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS). The testing results indicate that the improvement in cycling activity could be ascribed to the thinner cathode electrolyte interface film originated from SDPN on the LIB using LiNi1/3Co1/3Mn1/3O2, which reduced the interfacial resistance at a high voltage, but also protected the decomposition of electrolytes and suppressed transition metal dissolution.

  4. 3,3'-(Ethylenedioxy)dipropiononitrile as an Electrolyte Additive for 4.5 V LiNi1/3Co1/3Mn1/3O2/Graphite Cells.

    PubMed

    Wang, Chengyun; Yu, Le; Fan, Weizhen; Liu, Jiangwen; Ouyang, Liuzhang; Yang, Lichun; Zhu, Min

    2017-03-22

    3,3'-(Ethylenedioxy)dipropiononitrile (EDPN) has been introduced as a novel electrolyte additive to improve the oxidation stability of the conventional carbonate-based electrolyte for LiNi1/3Co1/3Mn1/3O2/graphite pouch batteries cycled under high voltage. Mixing 0.5 wt % EDPN into the electrolyte greatly improved the capacity retention, from 32.5% to 83.9%, of cells cycled for 100 times in the range 3.0-4.5 V with a rate of 1C. The high rate performance (3C and 5C) was also improved, while the cycle performance was similar to that of the cell without EDPN when cycled between 3.0 and 4.2 V. Further evidence of a stable protective interphase film can be formed on the LiNi1/3Co1/3Mn1/3O2 electrode surface due to the presence of EDPN in the electrolyte. This process effectively suppresses the oxidative decomposition of electrolyte and the growth in the charge-transfer resistance of the LiNi1/3Co1/3Mn1/3O2 electrode and greatly improves the high-voltage electrochemical properties for the cells. In contrast, EDPN has no positive effect on the cyclic performance of the LiNi0.5Co0.2Mn0.3O2-based cell under high operating voltage.

  5. Comparative genomic analysis of the swine pathogen Bordetella bronchisepticastrain KM22.

    PubMed

    Nicholson, Tracy L; Shore, Sarah M; Register, Karen B; Bayles, Darrell O; Kingsley, Robert A; Brunelle, Brain W

    2016-01-01

    The well-characterized Bordetella bronchiseptica strain KM22, originally isolated from a pig with atrophic rhinitis, has been used to develop a reproducible swine respiratory disease model. The goal of this study was to identify genetic features unique to KM22 by comparing the genome sequence of KM22 to the laboratory reference strain RB50. To gain a broader perspective of the genetic relationship of KM22 among other B. bronchiseptica strains, selected genes of KM22 were then compared to five other B. bronchiseptica strains isolated from different hosts. Overall, the KM22 genome sequence is more similar to the genome sequences of the strains isolated from animals than the strains isolated from humans. The majority of virulence gene expression in Bordetella is positively regulated by the two-component sensory transduction system BvgAS. bopN, bvgA, fimB, and fimC were the most highly conserved BvgAS-regulated genes present in all seven strains analyzed. In contrast, the BvgAS-regulated genes present in all seven strains with the highest sequence divergence werefimN, fim2, fhaL, andfhaS. A total of eight major fimbrial subunit genes were identified in KM22. Quantitative real-time PCR data demonstrated that seven of the eight fimbrial subunit genes identified in KM22 are expressed and regulated by BvgAS. The annotation of the KM22 genome sequence, coupled with the comparative genomic analyses reported in this study, can be used to facilitate the development of vaccines with improved efficacy towards B. bronchiseptica in swine to decrease the prevalence and disease burden caused by this pathogen.

  6. 10 km running performance predicted by a multiple linear regression model with allometrically adjusted variables

    PubMed Central

    Abad, Cesar C. C.; Barros, Ronaldo V.; Bertuzzi, Romulo; Gagliardi, João F. L.; Lima-Silva, Adriano E.; Lambert, Mike I.

    2016-01-01

    Abstract The aim of this study was to verify the power of VO2max, peak treadmill running velocity (PTV), and running economy (RE), unadjusted or allometrically adjusted, in predicting 10 km running performance. Eighteen male endurance runners performed: 1) an incremental test to exhaustion to determine VO2max and PTV; 2) a constant submaximal run at 12 km·h−1 on an outdoor track for RE determination; and 3) a 10 km running race. Unadjusted (VO2max, PTV and RE) and adjusted variables (VO2max0.72, PTV0.72 and RE0.60) were investigated through independent multiple regression models to predict 10 km running race time. There were no significant correlations between 10 km running time and either the adjusted or unadjusted VO2max. Significant correlations (p < 0.01) were found between 10 km running time and adjusted and unadjusted RE and PTV, providing models with effect size > 0.84 and power > 0.88. The allometrically adjusted predictive model was composed of PTV0.72 and RE0.60 and explained 83% of the variance in 10 km running time with a standard error of the estimate (SEE) of 1.5 min. The unadjusted model composed of a single PVT accounted for 72% of the variance in 10 km running time (SEE of 1.9 min). Both regression models provided powerful estimates of 10 km running time; however, the unadjusted PTV may provide an uncomplicated estimation. PMID:28149382

  7. Dosimetry of secondary cosmic radiation up to an altitude of 30 km.

    PubMed

    Wissmann, F; Burda, O; Khurana, S; Klages, T; Langner, F

    2014-10-01

    Dosimetric measurements in the field of secondary cosmic radiation were extensively made during the last years. Since the majority of these measurements were performed on-board passenger aircraft at altitudes between 10 and 12 km, measurements at higher altitudes are desirable for the verification of the legal dose assessment procedures for aircrew. A simple solution is to use a high-altitude balloon that reaches altitudes as high as 30 km. In this work, it is shown that the dose rate profile up to 30 km can be measured with acceptable uncertainties using a Si-detector.

  8. Characterization of the KM3NeT photomultipliers in the Hellenic Open University

    SciTech Connect

    Bourlis, G.; Avgitas, T.; Tsirigotis, A.; Tzamarias, S.; Collaboration: KM3NeT Collaboration

    2014-11-18

    The KM3NeT neutrino research infrastructure will be a deep sea multidisciplinary observatory in the Mediterranean Sea hosting a neutrino telescope. The Physics Laboratory of the Hellenic Open University is involved in the characterization of the KM3NeT neutrino detector. The present work describes measurement techniques for the functional characteristics of the candidate KM3NeT photomultipliers. These characteristics include dark current, transit time spread, gain slope and single photoelectron characteristics, as well as delayed and after pulses.

  9. KM3NeT/ARCA sensitivity and discovery potential for neutrino point-like sources

    NASA Astrophysics Data System (ADS)

    Trovato, A.

    2016-04-01

    KM3NeT is a large research infrastructure with a network of deep-sea neutrino telescopes in the abyss of the Mediterranean Sea. Of these, the KM3NeT/ARCA detector, installed in the KM3NeT-It node of the network, is optimised for studying high-energy neutrinos of cosmic origin. Sensitivities to galactic sources such as the supernova remnant RXJ1713.7-3946 and the pulsar wind nebula Vela X are presented as well as sensitivities to a generic point source with an E-2 spectrum which represents an approximation for the spectrum of extragalactic candidate neutrino sources.

  10. Hydrologic monitoring in 1-km2 headwater catchments in Sierra Nevada forests for predictive modeling of hydrologic response to forest treatments across 140-km2 firesheds

    NASA Astrophysics Data System (ADS)

    Saksa, P. C.; Bales, R. C.; Conklin, M. H.; Martin, S. E.; Rice, R.

    2010-12-01

    As part of the Sierra Nevada Adaptive Management Project, an eight-year study designed to measure the impacts of forest treatments (thinning, mastication, controlled burns) on multiple forest attributes, four headwater catchments were established to provide data on hydrologic response to treatments. These 1-km2 study catchments are each sited within 40-100 km2 firesheds, which in this case largely follow watershed boundaries, and which are the larger study areas for informing adaptive management of approximately 3,000 km2 of mixed-conifer forest in California’s central and southern Sierra Nevada. The aim of the hydrologic design was to put in place a ground-based monitoring network that would measure hydrologic attributes at representative locations, and when combined with remotely sensed data, provide a basis for predictive modeling of the larger study area. The selected locations employ instrument clusters, or groupings of instruments in a compact arrangement, to maximize the number of measurements possible and accessibility to the monitoring sites. The two study firesheds , located in the Tahoe and Sierra National Forests, cover a total of about 140-km2. Within each fireshed, two meteorological stations were placed near 1650-m and 2150-m, spanning the precipitation gradient from lower-elevation rain-dominated to higher-elevation snow-dominated systems. Two headwater streams draining approximately 1-km2 are monitored for stage, discharge, electrical conductivity, and sediment movement. Additionally, instrument nodes to monitor temperature, snow depth and soil moisture are installed within 0.5-1 km of the outlet and meterological stations. These nodes were placed to monitor end members of aspect, slope, elevation and canopy cover, which set the boundaries for the model outputs. High-resolution LiDAR provides the topographic and distributed vegetation characteristics, which are combined with field surveys and standard soils information to define the modeling

  11. Extreme precipitation events in southestearn France in a high-resolution regional climate model : comparison of a 12 km and a 50 km hindcast with ALADIN-Climate

    NASA Astrophysics Data System (ADS)

    Colin, Jeanne; Déqué, Michel; Sanchez Gomez, Emilia; Somot, Samuel

    2010-05-01

    We present a comparison of the modelling of intense precipitations over France in two regional climate simulations performed with the Limited Area Model (LAM) ALADIN-Climate, run at a 12 km and a 50 km resolution. In both experiments, the model is forced by the ERA40 re-analysis over the 1958-2000 period. We focus on the representation of the highest precipitation extremes occuring in southeastern France in Autumn. These events involve small-scale processes than can be explicitly resolved only with 2-1 km resolution non-hydrostatic models. However, previous studies have shown that regional climate models are able to simulate heavy rainfalls in this area, although the amounts of rain are much smaller than the ones that are actually observed. Here, we further explore the ability of ALADIN-Climate in reproducing these specific events and the possible added-value of a higher resolution regarding this matter. Indeed, driving the LAM with ERA40 allows the LAM to stick to the real chronology and therefore enables us to analyze its results not only from a statistical point of view but also through day-to-day diagnosis. First, we assess the performances of the model at the 12 km and 50 km resolutions by comparing the simulated daily precipitations with observations over the south east part of France. To do so, we use the high-resolution gridded SAFRAN analysis which provides series of hourly fields over the french territory at a 8 km resolution, from 1958 to 2008. We consider the differences in the upper quantiles of precipitations between the model and the data, as well as the time correlations of heavy rainfalls and the spatial rain patterns for given extreme events. Then we compare the performances of ALADIN-Climate in both simulations to the ones obtained with a statistical downscaling method we apply to the last twenty years of the ERA40 period. This method is based on a weather regime approach and uses the analog methodology (Boé and Terray, 2007) to reconstruct

  12. Crustal structure of the SW-Moroccan margin from wide-angle and reflection seismic data (the DAKHLA experiment) Part A: Wide-angle seismic models

    NASA Astrophysics Data System (ADS)

    Klingelhoefer, F.; Labails, C.; Cosquer, E.; Rouzo, S.; Géli, L.; Aslanian, D.; Olivet, J.-L.; Sahabi, M.; Nouzé, H.; Unternehr, P.

    2009-04-01

    A total 1500 km of seismic reflection and wide-angle profiles were acquired off the southern Moroccan margin during the DAKHLA cruise, a joint project of Ifremer, the Universities of Brest, El Jadida and Lisbon and Total. The shots along two profiles parallel to the margin and two profiles perpendicular to the margin were also recorded by ocean bottom seismometers (OBS). The profiles perpendicular to the margin were additionally extended on land using 14 stations on the northern profile and 11 stations on the southern profile. Modelling of the reflection and wide-angle seismic data reveals a 10 km deep sedimentary basin including two high velocity carbonate layers. Lateral crustal thinning is observed from a 27 km thick crystalline continental crust to a 7 km thick oceanic crust occurring over less than 100 km. The crystalline continental crust can be divided into two distinct layers of 12 and 15 km thickness. The oceanic crust east of the magnetic anomaly M25 displays higher velocities in layer 3 than west of the magnetic anomaly. The change in seismic velocity suggests a possible link to changes in accretionary processes of the oceanic crust. Some regions show seismic velocities between 6.8 and 7.4 km/s which could be explained by slightly elevated mantle temperatures during accretion of the crust.

  13. Wide swath and high resolution optical imaging satellite of Japan

    NASA Astrophysics Data System (ADS)

    Katayama, Haruyoshi; Kato, Eri; Imai, Hiroko; Sagisaka, Masakazu

    2016-05-01

    The "Advanced optical satellite" (tentative name) is a follow-on mission from ALOS. Mission objectives of the advanced optical satellite is to build upon the existing advanced techniques for global land observation using optical sensors, as well as to promote data utilization for social needs. Wide swath and high resolution optical imager onboard the advanced optical satellite will extend the capabilities of earlier ALOS missions. The optical imager will be able to collect high-resolution (< 1 m) and wide-swath (70 km) images with high geo-location accuracy. This paper introduces a conceptual design of the advanced optical satellite.

  14. LIP: The Livermore Interpolation Package, Version 1.3

    SciTech Connect

    Fritsch, F N

    2011-01-04

    This report describes LIP, the Livermore Interpolation Package. Because LIP is a stand-alone version of the interpolation package in the Livermore Equation of State (LEOS) access library, the initials LIP alternatively stand for the ''LEOS Interpolation Package''. LIP was totally rewritten from the package described in [1]. In particular, the independent variables are now referred to as x and y, since the package need not be restricted to equation of state data, which uses variables {rho} (density) and T (temperature). LIP is primarily concerned with the interpolation of two-dimensional data on a rectangular mesh. The interpolation methods provided include piecewise bilinear, reduced (12-term) bicubic, and bicubic Hermite (biherm). There is a monotonicity-preserving variant of the latter, known as bimond. For historical reasons, there is also a biquadratic interpolator, but this option is not recommended for general use. A birational method was added at version 1.3. In addition to direct interpolation of two-dimensional data, LIP includes a facility for inverse interpolation (at present, only in the second independent variable). For completeness, however, the package also supports a compatible one-dimensional interpolation capability. Parametric interpolation of points on a two-dimensional curve can be accomplished by treating the components as a pair of one-dimensional functions with a common independent variable. LIP has an object-oriented design, but it is implemented in ANSI Standard C for efficiency and compatibility with existing applications. First, a ''LIP interpolation object'' is created and initialized with the data to be interpolated. Then the interpolation coefficients for the selected method are computed and added to the object. Since version 1.1, LIP has options to instead estimate derivative values or merely store data in the object. (These are referred to as ''partial setup'' options.) It is then possible to pass the object to functions that

  15. A novel process for recycling and resynthesizing LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} from the cathode scraps intended for lithium-ion batteries

    SciTech Connect

    Zhang, Xihua; Xie, Yongbing; Cao, Hongbin; Nawaz, Faheem; Zhang, Yi

    2014-09-15

    Highlights: • A simple process to recycle cathode scraps intended for lithium-ion batteries. • Complete separation of the cathode material from the aluminum foil is achieved. • The recovered aluminum foil is highly pure. • LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} is directly resynthesized from the separated cathode material. - Abstract: To solve the recycling challenge for aqueous binder based lithium-ion batteries (LIBs), a novel process for recycling and resynthesizing LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} from the cathode scraps generated during manufacturing process is proposed in this study. Trifluoroacetic acid (TFA) is employed to separate the cathode material from the aluminum foil. The effects of TFA concentration, liquid/solid (L/S) ratio, reaction temperature and time on the separation efficiencies of the cathode material and aluminum foil are investigated systematically. The cathode material can be separated completely under the optimal experimental condition of 15 vol.% TFA solution, L/S ratio of 8.0 mL g{sup −1}, reacting at 40 °C for 180 min along with appropriate agitation. LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} is successfully resynthesized from the separated cathode material by solid state reaction method. Several kinds of characterizations are performed to verify the typical properties of the resynthesized LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} powder. Electrochemical tests show that the initial charge and discharge capacities of the resynthesized LiNi{sub 1/3}Co{sub 1/3}Mn{sub 1/3}O{sub 2} are 201 mAh g{sup −1} and 155.4 mAh g{sup −1} (2.8–4.5 V, 0.1 C), respectively. The discharge capacity remains at 129 mAh g{sup −1} even after 30 cycles with a capacity retention ratio of 83.01%.

  16. Heavy metal effects on the biodegradation of fluorene by Sphingobacterium sp. KM-02 isolated from PAHs-contaminated mine soil

    NASA Astrophysics Data System (ADS)

    Nam, I.; Chon, C.; Jung, K.; Kim, J.

    2012-12-01

    Polycyclic aromatic hydrocarbon compounds (PAHs) are widely distributed in the environment and occur ubiquitously in fossil fuels as well as in products of incomplete combustion and are known to be strongly toxic, often with carcinogenic and mutagenic properties. Fluorene is one of the 16 PAHs included in the list of priority pollutants of the Environmental Protection Agency. The fluorene-degrading bacterial strain Sphingobacterium sp. KM-02 was isolated from PAHs-contaminated soil near an abandoned mine impacted area by selective enrichment techniques. Fluorene added to the Sphingobacterium sp. KM-02 culture as sole carbon and energy source was 78.4% removed within 120 h. A fluorene degradation pathway is tentatively proposed based on mass spectrometric identification of the metabolic intermediates 9-fluorenone, 4-hydroxy-9-fluorenone, and 8-hydroxy-3,4-benzocoumarin. Further the ability of Sphingobacterium sp. KM-02 to bioremediate 100 mg/kg fluorene in mine soil was examined by composting under laboratory conditions. Treatment of microcosm soil with the strain KM-02 for 20 days resulted in a 65.6% reduction in total amounts. These results demonstrate that Sphingobacterium sp. KM-02 could potentially be used in the bioremediation of fluorene from contaminated soil. Mine impacted area comprises considerable amounts of heavy metals such as cadmium, lead, mercury, arsenic, and copper. Although some of these metals are necessary for biological life, excessive quantities often result in the inhibition of essential biological reactions via numerous pathways. A number of reports collectively show that various metals, such as Al, Co, Ni, Cu, Zn, Pb, and Hg at a range of concentrations have adverse effects on the degradation of organic compounds. However, at present there is only limited information on the effect of individual heavy metals on the biological degradation of polyaromatic hydrocarbons (PAHs) including fluorene. Moreover, heavy metal effects were not

  17. Mapping Land Cover Types in Amazon Basin Using 1km JERS-1 Mosaic

    NASA Technical Reports Server (NTRS)

    Saatchi, Sassan S.; Nelson, Bruce; Podest, Erika; Holt, John

    2000-01-01

    In this paper, the 100 meter JERS-1 Amazon mosaic image was used in a new classifier to generate a I km resolution land cover map. The inputs to the classifier were 1 km resolution mean backscatter and seven first order texture measures derived from the 100 m data by using a 10 x 10 independent sampling window. The classification approach included two interdependent stages: 1) a supervised maximum a posteriori Bayesian approach to classify the mean backscatter image into 5 general land cover categories of forest, savannah, inundated, white sand, and anthropogenic vegetation classes, and 2) a texture measure decision rule approach to further discriminate subcategory classes based on taxonomic information and biomass levels. Fourteen classes were successfully separated at 1 km scale. The results were verified by examining the accuracy of the approach by comparison with the IBGE and the AVHRR 1 km resolution land cover maps.

  18. Making sense of KM through users: Information gaps and intellectual property

    NASA Astrophysics Data System (ADS)

    Pascual, Roberto de Miguel; Casado, Esther Monterroso

    2014-10-01

    Despite its lack of definition, in a general sense, knowledge management (KM) is consubstantial to contemporary innovation-driven social systems (IDSSs), allowing individuals, organizations, and entire societies, to cope with their intrinsic technical uncertainties more effectively. Before the advent of IDSSs, most of the results of KM were considered naturally inappropriable as well as fractions of the public domain. In such context, patents litigation was almost anecdotic. This paper summarizes various social scientific and humanistic approaches that nourish the emergence of a new KM model in which innovation will be anchored in the claim for universality. Patentability of ICT and services is also considered on the realm of a commons-based KM.

  19. KM3NeT tower data acquisition and data transport electronics

    NASA Astrophysics Data System (ADS)

    Nicolau, C. A.; Ameli, F.; Biagioni, A.; Capone, A.; Frezza, O.; Lonardo, A.; Masullo, R.; Mollo, C. M.; Orlando, A.; Simeone, F.; Vicini, P.

    2016-04-01

    In the framework of the KM3Net European project, the production stage of a large volume underwater neutrino telescope has started. The forthcoming installation includes 8 towers and 24 strings, that will be installed 100 km off-shore Capo Passero (Italy) at 3500 m depth. The KM3NeT tower, whose layout is strongly based on the NEMO Phase-2 prototype tower deployed in March 2013, has been re-engineered and partially re-designed in order to optimize production costs, power consumption, and usability. This contribution gives a description of the main electronics, including front-end, data transport and clock distribution system, of the KM3NeT tower detection unit.

  20. 2 GHz clock quantum key distribution over 260 km of standard telecom fiber.

    PubMed

    Wang, Shuang; Chen, Wei; Guo, Jun-Fu; Yin, Zhen-Qiang; Li, Hong-Wei; Zhou, Zheng; Guo, Guang-Can; Han, Zheng-Fu

    2012-03-15

    We report a demonstration of quantum key distribution (QKD) over a standard telecom fiber exceeding 50 dB in loss and 250 km in length. The differential phase shift QKD protocol was chosen and implemented with a 2 GHz system clock rate. By careful optimization of the 1 bit delayed Faraday-Michelson interferometer and the use of the superconducting single photon detector (SSPD), we achieved a quantum bit error rate below 2% when the fiber length was no more than 205 km, and of 3.45% for a 260 km fiber with 52.9 dB loss. We also improved the quantum efficiency of SSPD to obtain a high key rate for 50 km length.

  1. 40 Gbps 100-km SSMF VSB-IMDD OFDM transmission experiment based on FBG filter

    NASA Astrophysics Data System (ADS)

    Ju, Cheng; Yang, Pengfei; Chen, Xue; Zhang, Zhiguo; Liu, Na

    2014-10-01

    This work studies the transmission performance of vestigial-sideband (VSB)-IMDD OFDM system by theoretical analysis and numerical simulation. The analysis shows that the detrimental effect of dispersion-induced power fading can be effectively suppressed. The presence of positive and negative chirp of modulator will increase the dispersion-, chirp- and VSB optical filter-induced subcarrier to subcarrier intermixing interference (SSII), which significantly restricts transmission performance. Relatively lower order Gaussian optical filter has almost the same performance with ideal rectangular filter over 100-km SMF transmission and have better performance in less than 60-km transmission. Furthermore, we successfully transmit a 40 Gbps, 16QAM, MZM-based VSB-IMDD OFDM signal through 100-km of uncompensated standard single mode fiber (SSMF) by using an economical FBG optical filter. The experimental results show that available bandwidth has been extended up to 10 GHz after 100-km SSMF transmission.

  2. A Theoretical Study on Stepwise- and Concertedness of the Mechanism of 1,3-Dipolar Cycloaddition Reaction Between Tetra Amino Ethylene and Trifluoro Methyl Azide.

    PubMed

    Siadati, Seyyed Amir

    2016-01-01

    The order of reaction, especially in 1,3-dipolar cycloadditions directly affects the products' stereo selectivity. Due to this fact that a wide range of heterocyclic rings of natural products and biologically active molecules are synthesizing via this valuable procedure, understanding about the order of this reaction is so useful in designing the synthesis of different types of heterocyclic species. Therefore, the order of 1, 3-dipolar reaction has been carefully studied by many researchers but it seems that this question is still open despite many valuable answers. Considering this, in the present work, it is attempted to pursue this subject by theoretical investigation of any possible pathway of 1, 3-dipolar reaction of tetra amino ethylene as a highly electron rich dipolarophile and trifluoro methyl azide as an electron poor 1,3-dipole. During the calculations, one, two, and three step mechanism(s) have been found to be possible for the present 1, 3-dipolar reaction.

  3. Long-term monitoring of local stress changes in 67km installed OPGW cable using BOTDA

    NASA Astrophysics Data System (ADS)

    Zou, L.; Sezerman, O.

    2015-09-01

    The initial results from continuing long-term monitoring of a 67 km of an aerial fiber optic cable installed on a 500 kV power line cable (total fiber length of 134km) using BOTDA are presented. The effects of thunderstorms and rime ice on the cable were identified by monitoring strain on OPGW fibers. Variations of strain between day and night on the OPGW cable were observed and can potentially be exploited.

  4. 91-km attenuation-free transmission with low noise accumulation by use of distributed erbium-doped fiber

    NASA Astrophysics Data System (ADS)

    Lester, Christian; Rottwitt, Karsten; Povlsen, Jørn H.; Varming, Poul; Newhouse, Mark A.; Antos, A. J.

    1995-06-01

    Transparency of a 91-km distributed erbium-doped fiber is achieved with 0.46 mW / km of pump power at a signal power of -12dBm . The accumulation of amplifier noise is measured to be smaller than the minimum noise accumulation that can be achieved in a 91-km link with two lumped amplifiers separated by 45 km.

  5. Daytime zonal drifts in the ionospheric E and 150 km regions estimated using EAR observations

    NASA Astrophysics Data System (ADS)

    Peddapati, PavanChaitanya; Otsuka, Yuichi; Yamamoto, Mamoru; Yokoyama, Tatsuhiro; Patra, Amit

    2016-07-01

    The Equatorial Atmosphere Radar (EAR), located at Kototabang (0.2o S, 100.32o E, mag. lat. 10.36o S), Indonesia, is capable of detecting both E region and 150 km echoes during daytime. We have conducted multi-beam observations using the EAR during daytime covering all seasons to study seasonal variations of these echoes and their dynamics. Given the facts that drifts at the 150 km region are governed primarily by electric field, drifts at the E region are governed by both electric field and neutral wind, simultaneous observations of drifts in both E and 150 km regions would help understand their variations. In this paper we present local time and seasonal variations of zonal drifts in the E and 150 km regions estimated using multi-beam observations. Zonal drifts (positive eastward) in the E and 150 km regions are found to be in the range of -10 to -60 m/s and -40 to 80 m/s, respectively. In the E region, zonal drifts show height reversal and temporal variations having tidal signature and noticeable seasonal variations. Zonal drifts in the 150 km region also show noticeable height and seasonal variations. These results are compared with model drifts and evaluated in terms of electric field and neutral wind.

  6. Evaluation of the 29-km Eta Model. Part 1; Objective Verification at Three Selected Stations

    NASA Technical Reports Server (NTRS)

    Nutter, Paul A.; Manobianco, John; Merceret, Francis J. (Technical Monitor)

    1998-01-01

    This paper describes an objective verification of the National Centers for Environmental Prediction (NCEP) 29-km eta model from May 1996 through January 1998. The evaluation was designed to assess the model's surface and upper-air point forecast accuracy at three selected locations during separate warm (May - August) and cool (October - January) season periods. In order to enhance sample sizes available for statistical calculations, the objective verification includes two consecutive warm and cool season periods. Systematic model deficiencies comprise the larger portion of the total error in most of the surface forecast variables that were evaluated. The error characteristics for both surface and upper-air forecasts vary widely by parameter, season, and station location. At upper levels, a few characteristic biases are identified. Overall however, the upper-level errors are more nonsystematic in nature and could be explained partly by observational measurement uncertainty. With a few exceptions, the upper-air results also indicate that 24-h model error growth is not statistically significant. In February and August 1997, NCEP implemented upgrades to the eta model's physical parameterizations that were designed to change some of the model's error characteristics near the surface. The results shown in this paper indicate that these upgrades led to identifiable and statistically significant changes in forecast accuracy for selected surface parameters. While some of the changes were expected, others were not consistent with the intent of the model updates and further emphasize the need for ongoing sensitivity studies and localized statistical verification efforts. Objective verification of point forecasts is a stringent measure of model performance, but when used alone, is not enough to quantify the overall value that model guidance may add to the forecast process. Therefore, results from a subjective verification of the meso-eta model over the Florida peninsula are

  7. Leaching process for recovering valuable metals from the LiNi1/3Co1/3Mn1/3O2 cathode of lithium-ion batteries.

    PubMed

    He, Li-Po; Sun, Shu-Ying; Song, Xing-Fu; Yu, Jian-Guo

    2017-03-18

    In view of the importance of environmental protection and resource recovery, recycling of spent lithium-ion batteries (LIBs) and electrode scraps generated during manufacturing processes is quite necessary. An environmentally sound leaching process for the recovery of Li, Ni, Co, and Mn from spent LiNi1/3Co1/3Mn1/3O2-based LIBs and cathode scraps was investigated in this study. Eh-pH diagrams were used to determine suitable leaching conditions. Operating variables affecting the leaching efficiencies for Li, Ni, Co, and Mn from LiNi1/3Co1/3Mn1/3O2, such as the H2SO4 concentration, temperature, H2O2 concentration, stirring speed, and pulp density, were investigated to determine the most efficient conditions for leaching. The leaching efficiencies for Li, Ni, Co, and Mn reached 99.7% under the optimized conditions of 1M H2SO4, 1vol% H2O2, 400rpm stirring speed, 40g/L pulp density, and 60min leaching time at 40°C. The leaching kinetics of LiNi1/3Co1/3Mn1/3O2 were found to be significantly faster than those of LiCoO2. Based on the variation in the weight fraction of the metal in the residue, the "cubic rate law" was revised as follows: θ(1-f)(1/3)=(1-kt/r0ρ), which could characterize the leaching kinetics optimally. The activation energies were determined to be 64.98, 65.16, 66.12, and 66.04kJ/mol for Li, Ni, Co, and Mn, respectively, indicating that the leaching process was controlled by the rate of surface chemical reactions. Finally, a simple process was proposed for the recovery of valuable metals from spent LiNi1/3Co1/3Mn1/3O2-based LIBs and cathode scraps.

  8. Measurements of environmental 1,3-butadiene with pumped and diffusive samplers using the sorbent Carbopack X

    NASA Astrophysics Data System (ADS)

    Martin, Nicholas A.; Duckworth, Philippa; Henderson, Malcolm H.; Swann, Nigel R. W.; Granshaw, Simon T.; Lipscombe, Robert P.; Goody, Brian A.

    Studies with the sorbent Carbopack X in pumped and diffusive samplers, of the Perkin-Elmer-type, have been carried out using a controlled atmosphere test facility (CATFAC) to generate 1,3-butadiene, together with benzene, at environmental levels. The 7-day and 14-day 1,3-butadiene diffusive uptake rates for this sorbent have been determined to be respectively (1.24±0.16) ng ppm -1 min -1 ((0.55±0.07) cm 3 min -1)) and (1.02±0.12) ng ppm -1 min -1 ((0.45±0.05) cm 3 min -1)) under a wide range of concentrations at 20 °C, 50% relative humidity and a wind speed of 1 m s -1. Preliminary studies indicate that this sorbent may also be useful in radial diffusive samplers for short-term monitoring over a few hours. A pumped sampling method has been developed to measure both 1,3-butadiene and benzene simultaneously over a period of 14-days using two Perkin-Elmer-type devices coupled to an in-house developed controlled flow air sampler. The 1,3-butadiene safe sampling volume for Carbopack X has been measured yielding a value of ⩽82 litre g -1. Tests carried out with calibrated amounts of 1,3-butadiene (50 ng and 150 ng) on Carbopack X indicate that samplers should be stored in a refrigerator prior to thermal desorption in order to achieve a recovery of effectively 100%. Ambient ozone does not appear to react with 1,3-butadiene adsorbed in the samplers.

  9. Chemo-, regio-, and stereoselective cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha-chloroacetic acid chlorides and alpha-chloroacetic acetals.

    PubMed

    Langer, P; Krummel, T

    2001-04-17

    Treatment of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha-chlorocarboxylic acid chlorides resulted in chemo- and regioselective formation of 6-chloro3,5-dioxo esters, which were regioselectively converted into functionalised 3(2H)furanones. Chemo- and regioselective condensation of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha-chloroacetic dimethyl acetal afforded 6-chloro-5-methoxy-3-oxo esters, which could be regio- and stereoselectively transformed into 2-alkylidene-4-methoxytetrahydrofurans.

  10. The Trigger and Data Acquisition System for the KM3NeT neutrino telescope

    NASA Astrophysics Data System (ADS)

    Pellegrino, Carmelo; Chiarusi, Tommaso

    2016-04-01

    KM3NeT is a large research infrastructure in the Mediterranean Sea that includes a network of deep-sea neutrino telescopes. The telescopes consist of vertical detection units carrying optical modules, whose separation is optimised according to the different ranges of neutrino energy that shall be explored. Two building blocks, each one made of 115 detection units, will be deployed at the KM3NeT-IT site, about 80 km from Capo Passero, Italy, to search for high-energy neutrino sources (ARCA); another building block will be installed at the KM3NeT-Fr site, about 40 km from Toulon, France, to study the hierarchy of neutrino masses (ORCA). The modular design of the KM3NeT allows for a progressive implementation and data taking even with an incomplete detector. The same scalable design is used for the Trigger and Data Acquisition Systems (TriDAS). In order to reduce the complexity of the hardware inside the optical modules, the "all data to shore" concept is adopted. This implies that the throughput is dominated by the optical background due to the decay of 40K dissolved in the sea water and to the bursts of bioluminescence, about 3 orders of magnitude larger than the physics signal, ranging from 20 Gbps to several hundreds Gbps, according to the number of detection units. In addition, information from the acoustic positioning system of the detection units must be transmitted. As a consequence of the detector construction, the on-shore DAQ infrastructure must be expanded to handle an increasing data-rate and implement an efficient fast data filtering for both the optical and acoustic channels. In this contribution, the Trigger and Data Acquisition System designed for the Phase 1 of KM3NeT and its future expansion are presented. The network infrastructure, the shore computing resources and the developed applications for handling, filtering and monitoring the optical and acoustic data-streams are described.

  11. The isolated 678-km deep 30 May 2015 MW 7.9 Ogasawara (Bonin) Islands earthquake

    NASA Astrophysics Data System (ADS)

    Ye, L.; Lay, T.; Zhan, Z.; Kanamori, H.; Hao, J.

    2015-12-01

    Deep-focus earthquakes, located 300 to 700 km below the Earth's surface within sinking slabs of relatively cold oceanic lithosphere, are mysterious phenomena. Seismic radiation from deep events is essentially indistinguishable from that for shallow stick-slip frictional-sliding earthquakes, but the confining pressure and temperature are so high for deep-focus events that a distinct process is likely needed to account for their abrupt energy release. The largest recorded deep-focus earthquake (MW 7.9) in the Izu-Bonin slab struck on 30 May 2015 beneath the Ogasawara (Bonin) Islands, isolated from prior seismicity by over 100 km in depth, and followed by only 2 small aftershocks. Globally, this is the deepest (678 km) major (MW > 7) earthquake in the seismological record. Seismicity indicates along-strike contortion of the Izu-Bonin slab, with horizontal flattening near a depth of 550 km in the Izu region and progressive steepening to near-vertical toward the south above the location of the 2015 event. Analyses of a large global data set of P, SH and pP seismic phases using short-period back-projection, subevent directivity, and broadband finite-fault inversion indicate that the mainshock ruptured a shallowly-dipping fault plane with patchy slip that spread over a distance of ~40 km with variable expansion rate (~5 km/s down-dip initially, ~3 km/s up-dip later). During the 17 s rupture duration the radiated energy was ~3.3 x 1016 J and the stress drop was ~38 MPa. The radiation efficiency is moderate (0.34), intermediate to that of the 1994 Bolivia and 2013 Sea of Okhotsk MW 8.3 earthquakes, indicating a continuum of processes. The isolated occurrence of the event suggests that localized stress concentration associated with the pronounced deformation of the Izu-Bonin slab likely played a role in generating this major earthquake.

  12. Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs

    PubMed Central

    Durgashivaprasad, Ega; Mathew, Geetha; Sebastian, Sarine; Reddy, S.A Manohar; Mudgal, Jayesh; Nampurath, Gopalan Kutty

    2014-01-01

    Objective: 1,3,4-oxadiazole ring is a versatile moiety with a wide range of pharmacological properties. The present work deals with the synthesis and evaluation of the anti-inflammatory activity of two novel 2,5-disubstituted-1,3,4-oxadiazoles (OSD and OPD). Materials and Methods: Carrageenan-induced rat hind paw edema was employed as an acute model of inflammation. For evaluating sub-acute anti-inflammatory activity, carrageenan-induced inflammation in rat air pouch was employed. Complete Freund's adjuvant-induced arthritis in rats was used as a model of chronic inflammation. To evaluate in vitro anti-inflammatory activity, lipopolysaccharide (LPS)-stimulated RAW264.7 cells were used. Results: OSD (100 mg/kg) reduced carrageen-induced paw edema by 60%, and OPD (100 mg/kg) produced a modest 32.5% reduction. OSD also reduced leukocyte influx and myeloperoxidase in carrageenan-induced rat air pouch model. In complete Freund's adjuvant-induced arthritis model, both OSD and OPD (200 mg/kg for 14 days) reduced paw edema and NO levels. In LPS-stimulated RAW264.7 cells, OSD and OPD inhibited formation of nitric oxide and reactive oxygen species, with OPD showing a better activity in comparison to OSD. Conclusions: OSD was the better of the two compounds in in vivo models of inflammation. The o-phenol substitution at position 2 of oxadiazole ring in OSD may be responsible for its better in vivo anti-inflammatory activity. The ability of the compounds to inhibit LPS-induced pro-inflammatory mediator release suggests an anti-inflammatory mechanism targeting LPS-TLR4-NF-κB signalling pathway, which needs to be explored in detail. The disparate efficacy in vitro and in vivo also requires in-depth evaluation of the pharmacokinetics of these novel oxadiazoles. PMID:25298582

  13. The galaxy cluster mid-infrared luminosity function at 1.3 < z < 3.2

    SciTech Connect

    Wylezalek, Dominika; Vernet, Joël; De Breuck, Carlos; Stern, Daniel; Brodwin, Mark; Galametz, Audrey; Gonzalez, Anthony H.; Jarvis, Matt; Hatch, Nina; Seymour, Nick; Stanford, Spencer A.

    2014-05-01

    We present 4.5 μm luminosity functions for galaxies identified in 178 candidate galaxy clusters at 1.3 < z < 3.2. The clusters were identified as Spitzer/Infrared Array Camera (IRAC) color-selected overdensities in the Clusters Around Radio-Loud AGN project, which imaged 420 powerful radio-loud active galactic nuclei (RLAGNs) at z > 1.3. The luminosity functions are derived for different redshift and richness bins, and the IRAC imaging reaches depths of m* + 2, allowing us to measure the faint end slopes of the luminosity functions. We find that α = –1 describes the luminosity function very well in all redshift bins and does not evolve significantly. This provides evidence that the rate at which the low mass galaxy population grows through star formation gets quenched and is replenished by in-falling field galaxies does not have a major net effect on the shape of the luminosity function. Our measurements for m* are consistent with passive evolution models and high formation redshifts (z{sub f} ∼ 3). We find a slight trend toward fainter m* for the richest clusters, implying that the most massive clusters in our sample could contain older stellar populations, yet another example of cosmic downsizing. Modeling shows that a contribution of a star-forming population of up to 40% cannot be ruled out. This value, found from our targeted survey, is significantly lower than the values found for slightly lower redshift, z ∼ 1, clusters found in wide-field surveys. The results are consistent with cosmic downsizing, as the clusters studied here were all found in the vicinity of RLAGNs—which have proven to be preferentially located in massive dark matter halos in the richest environments at high redshift—and they may therefore be older and more evolved systems than the general protocluster population.

  14. Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol.

    PubMed

    Xiu, Zhi-Long; Zeng, An-Ping

    2008-04-01

    1,3-Propanediol and 2,3-butanediol are two promising chemicals which have a wide range of applications and can be biologically produced. The separation of these diols from fermentation broth makes more than 50% of the total costs in their microbial production. This review summarizes the present state of methods studied for the recovery and purification of biologically produced diols, with particular emphasis on 1,3-propoanediol. Previous studies on the separation of 1,3-propanediol primarily include evaporation, distillation, membrane filtration, pervaporation, ion exchange chromatography, liquid-liquid extraction, and reactive extraction. Main methods for the recovery of 2,3-butanediol include steam stripping, pervaporation, and solvent extraction. No single method has proved to be simple and efficient, and improvements are especially needed with regard to yield, purity, and energy consumption. Perspectives for an improved downstream processing of biologically produced diols, especially 1,3-propanediol are discussed based on our own experience and recent work. It is argued that separation technologies such as aqueous two-phase extraction with short chain alcohols, pervaporation, reverse osmosis, and in situ extractive or pervaporative fermentations deserve more attention in the future.

  15. Combustion of Hazard Division 1.3 M1 Gun Propellant in a Reinforced Concrete Structure

    DTIC Science & Technology

    2015-08-01

    II-A-1 II-B. HD1.3 Test 1. Temperature and Flux Data ...............................................II-B-1 II-C. HD1.3 Test 1. High-Speed Camera...HD1.3 Test 2. IR and High-Speed Camera Coverage (See DVD) ......... III-B-1 III-C. HD1.3 Test 2. Temperature and Thermal Flux Data...IV-A-1 IV-B. HD1.3 Test 3. Temperature and Flux Data .......................................... IV-B-1 IV-C. HD1.3 Test 3. Infrared Images

  16. System Wide Information Management (SWIM)

    NASA Technical Reports Server (NTRS)

    Hritz, Mike; McGowan, Shirley; Ramos, Cal

    2004-01-01

    This viewgraph presentation lists questions regarding the implementation of System Wide Information Management (SWIM). Some of the questions concern policy issues and strategies, technology issues and strategies, or transition issues and strategies.

  17. Participation and performance trends in 100-km ultra-marathons worldwide.

    PubMed

    Cejka, Nadine; Rüst, Christoph Alexander; Lepers, Romuald; Onywera, Vincent; Rosemann, Thomas; Knechtle, Beat

    2014-01-01

    The aims of the present study were to (1) investigate the participation trends for the origin of athletes competing in 100-km ultra-marathons and (2) determine the nationalities of athletes achieving the fastest 100-km race times worldwide. Race times and nationality from 112,283 athletes (15,204 women and 97,079 men) from 102 countries who completed a 100-km ultra-marathon worldwide between 1998 and 2011 were investigated using single- and multi-level regression analyses. The number of finishers increased exponentially, both for women and men. Most of the finishers (73.5%) were from Europe, in particular, France (30.4%). The number of finishers from Japan, Germany, Italy, Poland and the United States of America increased exponentially during the studied period. For women, runners from Canada became slower while those from Italy became faster over time. For men, runners from Belgium, Canada and Japan became slower. Between 1998 and 2011, the ten best race times were achieved by Japanese runners for both women with 457.1 (s = 28.8) min and men with 393.4 (s = 9.6) min. To summarise, most of the finishers in 100-km ultra-marathons originated from Europe, but the best performances belong to Japanese runners. Although East African runners dominate running up to a marathon, Japanese were the best in 100 km.

  18. The Effect of Boron on the Low Cycle Fatigue Behavior of Disk Alloy KM4

    NASA Technical Reports Server (NTRS)

    Gabb, Timothy; Gayda, John; Sweeney, Joseph

    2000-01-01

    The durability of powder metallurgy nickel base superalloys employed as compressor and turbine disks is often limited by low cycle fatigue (LCF) crack initiation and crack growth from highly stressed surface locations (corners, holes, etc.). Crack growth induced by dwells at high stresses during aerospace engine operation can be particularly severe. Supersolvus solution heat treatments can be used to produce coarse grain sizes approaching ASTM 6 for improved resistance to dwell fatigue crack growth. However, the coarse grain sizes reduce yield strength, which can lower LCF initiation life. These high temperature heat treatments also can encourage pores to form. In the advanced General Electric disk superalloy KM4, such pores can initiate fatigue cracks that limit LCF initiation life. Hot isostatic pressing (HIP) during the supersolvus solution heat treatment has been shown to improve LCF initiation life in KM4, as the HIP pressure minimizes formation of the pores. Reduction of boron levels in KM4 has also been shown to increase LCF initiation life after a conventional supersolvus heat treatment, again possibly due to effects on the formation tendencies of these pores. However, the effects of reduced boron levels on microstructure, pore characteristics, and LCF failure modes in KM4 still need to be fully quantified. The objective of this study was to determine the effect of boron level on the microstructure, porosity, LCF behavior, and failure modes of supersolvus heat treated KM4.

  19. Operation and results of the prototype KM3NeT detection unit

    NASA Astrophysics Data System (ADS)

    Biagi, Simone

    2016-07-01

    KM3NeT will be a km3-scale neutrino telescope in the Mediterranean Sea. The detector will consist of blocks of about one hundred detection units. Each detection unit will host 18 digital optical modules, connected along a 700 m-long vertical structure. Electro-optical cables allow for data transmission and power supply to the optical modules. The optical module comprises 31 photomultiplier tubes of 3'', instruments to monitor environmental variables and electronic boards to communicate onshore and operate the photomultipliers. A prototype detection unit has been deployed in May 2014 at the KM3NeT-It installation site 80 km SE offshore of Capo Passero, Sicily. This prototype allowed to test the deployment procedures, the mechanics and the electronic of the apparatus, the data taking and analysis procedures. A general description of the detector and some results of the prototype are presented. The first detection unit of the KM3NeT neutrino telescope will be deployed and become operative by the end of 2015.

  20. M. tuberculosis ferritin (Rv3841): Potential involvement in Amikacin (AK) & Kanamycin (KM) resistance.

    PubMed

    Sharma, Divakar; Lata, Manju; Faheem, Mohammad; Khan, Asad Ullah; Joshi, Beenu; Venkatesan, Krishnamurthy; Shukla, Sangeeta; Bisht, Deepa

    2016-09-16

    Tuberculosis is an infectious disease, caused by one of the most successful human pathogen, Mycobacterium tuberculosis. Aminoglycosides, Amikacin (AK) & Kanamycin (KM) are commonly used to treat drug resistant tuberculosis. They target the protein synthesis machinery by interacting with several steps of translation. Several explanations have been proposed to explain the mechanism of aminoglycoside resistance but still our information is inadequate. Iron storing/interacting proteins were found to be overexpressed in aminoglycosides resistant isolates. Iron assimilation and utilization in M. tuberculosis plays a crucial role in growth, virulence and latency. To establish the relationship of ferritin with AK & KM resistance ferritin (Rv3841/bfrB) was cloned, expressed and antimicrobial drug susceptibility testing (DST) was carried out. Rv3841/bfrB gene was cloned and expressed in E. coli BL21 using pQE2 expression vector. Etest results for DST against AK & KM showed that the minimum inhibitory concentration (MIC) of ferritin recombinant cells was changed. Recombinants showed two fold changes in MIC with AK and three fold with KM E-strips. Overexpression of ferritin reflect the MIC shift which might be playing a critical role in the survival of mycobacteria by inhibiting/modulating the effects of AK & KM. String analysis also suggests that ferritin interacted with few proteins which are directly and indirectly involved in M. tuberculosis growth, Iron assimilation, virulence, resistance, stresses and latency.

  1. Greener and rapid access to bio-active heterocycles: one-pot solvent-free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

    EPA Science Inventory

    A novel one-pot solvent free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles by condensation of acid hydrazide and triethyl orthoalkanates under microwave irradiations is reported. This green protocol was catalyzed efficiently by solid supported Nafion®NR50 and phosphorus p...

  2. Trinuclear rare earth metal complexes based on 1,3,5-triamino-1,3,5-trideoxy-cis inositol as catalysts for the hydrolysis of phosphodiesters.

    PubMed

    Ramadan, Ahmed M; Calatayud Sala, José Miguel; Parac-Vogt, Tatjana N

    2011-02-14

    Trinuclear rare-earth metal complexes [M₃(taciH₋₃)₂](3+) (M = La(3+), Y(3+)), based on a rigid polyamino-polyalcohol ligand 1,3,5-triamino-1,3,5-trideoxy-cis-inositol (taci), are proven to be efficient catalysts for the hydrolysis of 2-hydroxypropyl-4-nitrophenyl phophate (HPNP), a commonly used RNA model system.

  3. Isoxazolium N-ylides and 1-oxa-5-azahexa-1,3,5-trienes on the way from isoxazoles to 2H-1,3-oxazines

    PubMed Central

    Novikov, Mikhail S; Gorbunova, Yelizaveta G; Galenko, Ekaterina E; Mikhailov, Kirill I; Pakalnis, Viktoriia V; Avdontceva, Margarita S

    2014-01-01

    Summary Theoretical and experimental studies of the reaction of isoxazoles with diazo compounds show that the formation of 2H-1,3-oxazines proceeds via the formation of (3Z)-1-oxa-5-azahexa-1,3,5-trienes which undergo a 6π-cyclization. The stationary points corresponding to the probable reaction intermediates, isoxazolium N-ylides, were located by DFT calculations at the B3LYP/6-31G(d) level only for derivatives without a substituent in position 3 of the isoxazole ring. These isoxazolium N-ylides are thermodynamically and kinetically very unstable. According to the calculations and experimental results 2H-1,3-oxazines are usually more thermodynamically stable than the corresponding open-chain isomers, (3Z)-1-oxa-5-azahexa-1,3,5-trienes. The exception are oxaazahexatrienes derived from 5-alkoxyisoxazoles, which are thermodynamically more stable than the corresponding 2H-1,3-oxazines. Therefore, the reaction of diazo esters with 5-alkoxyisoxazoles is a good approach to 1,4-di(alkoxycarbonyl)-2-azabuta-1,3-dienes. The reaction conditions for the preparation of aryl- and halogen-substituted 2H-1,3-oxazines and 1,4-di(alkoxycarbonyl)-2-azabuta-1,3-dienes from isoxazoles were investigated. PMID:25246948

  4. GENE EXPRESSION CHANGES IN ARABIDOPSIS THALIANA SEEDLING ROOTS EXPOSED TO THE MUNITION HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE

    EPA Science Inventory

    Arabidopsis thaliana root transcriptome responses to the munition, hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), were assessed using serial analysis of gene expression (SAGE). Comparison of the transcriptional profile for the RDX response to a profile previously described for Ar...

  5. Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats.

    PubMed

    Han, Jing; Liang, Hua; Yi, Jianhua; Tan, Wuhong; He, Shulan; Wang, Sen; Li, Feng; Wu, Xiaofang; Ma, Jing; Shi, Xiaowei; Guo, Xiong; Bai, Chuanyi

    2017-02-01

    The effects of selenium (Se)-deficient diet on the liver were evaluated by using growing rats which were fed with normal and Se-deficient diets, respectively, for 109 days. The results showed that rats fed with Se-deficient diet led to a decrease in Se concentration in the liver, particularly among male rats from the low-Se group. This causes alterations to the ultrastructure of hepatocytes with condensed chromatin and swelling mitochondria observed after low Se intake. Meanwhile, pathological changes and increased fibrosis in hepatic periportal were detected by hematoxylin and eosin and Masson's trichrome staining in low-Se group. Furthermore, through immunohistochemistry (IHC) staining, higher expressions of metalloproteinases (MMP1/3) and their tissue inhibitors of metalloproteinases (TIMP1/3) were observed in the hepatic periportal of rats from the low-Se group. However, higher expressions of MMP1/3 and lower expressions of TIMP1/3 were detected in hepatic central vein and hepatic sinusoid. In addition, upregulated expressions of MMP1/3 and downregulated expressions of TIMP1/3 at the messenger RNA (mRNA) and protein levels also appeared to be relevant to low Se intake. In conclusion, Se-deficient diet could cause low Se concentration in the liver, alterations of hepatocyte ultrastructure, differential expressions of MMP1/3 and TIMP1/3 as well as fibrosis in the liver hepatic periportal.

  6. Palladium-catalyzed stereoselective intramolecular oxidative amidation of alkenes in the synthesis of 1,3- and 1,4-amino alcohols and 1,3-diamines.

    PubMed

    Malkov, Andrei V; Lee, Darren S; Barłóg, Maciej; Elsegood, Mark R J; Kočovský, Pavel

    2014-04-22

    An efficient and practical Pd-catalyzed intramolecular oxidative allylic amidation provides facile access to derivatives of 1,3- and 1,4-amino alcohols and 1,3-diamines. The method operates under mild reaction conditions (RT) with molecular oxygen (1 atm) as the sole reoxidant of Pd. Excellent diastereoselectivities were attained with substrates bearing a secondary stereogenic center.

  7. Low-temperature structural and dielectric phenomena in La1/3NbO3 and La1/3TaO3: Comparative study

    NASA Astrophysics Data System (ADS)

    Salak, Andrei N.; Vyshatko, Nikolai P.; Khalyavin, Dmitry D.; Prokhnenko, Oleksandr; Ferreira, Victor M.

    2008-10-01

    The crystal structures of the perovskites La1/3NbO3 and La1/3TaO3 were studied between 10 and 350 K using high-resolution neutron powder diffraction and compared with their radio-frequency dielectric response over the same temperature range. The structure of La1/3NbO3 remains orthorhombic Cmmm, while La1/3TaO3 undergoes continuous transition from the high-temperature tetragonal P4/mmm to Cmmm phase at about 220 K. This transition is tricritical in nature and accompanied by no dielectric anomaly. In La1/3NbO3, the frequency-dependent peak of the dielectric permittivity is associated with an atypical increase in the lattice parameters below about 80 K.

  8. Combined analysis of the tobacco metabolites cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine.

    PubMed

    Kotandeniya, Delshanee; Carmella, Steven G; Ming, Xun; Murphy, Sharon E; Hecht, Stephen S

    2015-02-03

    Two of the most widely measured compounds in the urine of people who use tobacco products are cotinine, a major metabolite of the addictive constituent nicotine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of the powerful lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thousands of analyses have been reported in the literature, carried out exclusively, to the best of our knowledge, by separate methods. In the study reported here, we have developed a sensitive, accurate, and precise liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring method for the combined analysis of total cotinine (the sum of cotinine and its glucuronide) and total NNAL (the sum of NNAL and its glucuronide). The new method quantifies naturally occurring [(13)C]cotinine to minimize problems associated with the vast differences in concentration of total cotinine and total NNAL in urine. This method should greatly facilitate future determinations of these important compounds.

  9. A new recombinant endo-1,3-β-D-glucanase from the marine bacterium Formosa algae KMM 3553: enzyme characteristics and transglycosylation products analysis.

    PubMed

    Kusaykin, Mikhail I; Belik, Alexey A; Kovalchuk, Svetlana N; Dmitrenok, Pavel S; Rasskazov, Valerii A; Isakov, Vladimir V; Zvyagintseva, Tatyana N

    2017-02-01

    A specific endo-1,3-β-D-glucanase (GFA) gene was found in genome of marine bacterium Formosa algae KMM 3553. For today this is the only characterized endo-1,3-β-D-glucanase (EC 3.2.1.39) in Formosa genus and the only bacterial EC 3.2.1.39 GH16 endo-1,3-β-D-glucanase with described transglycosylation activity. It was expressed in E. coli and isolated in homogeneous state. Investigating the products of polysaccharides digestion with GFA allowed to establish it's substrate specificity and classify this enzyme as glucan endo-1,3-β-D-glucosidase (EC 3.2.1.39). The amino-acid sequence of GFA consists of 556 residues and shows sequence similarity of 45-85% to β-1,3-glucanases of bacteria belonging to the CAZy 16th structural family of glycoside hydrolases GH16. Enzyme has molecular weight 61 kDa, exhibits maximum of catalytic activity at 45 °C, pH 5.5. Half-life period at 45 °С is 20 min, complete inactivation happens at 55 °C within 10 min. Km for hydrolysis of laminarin is 0.388 mM. GFA glucanase from marine bacteria F. algae is one of rare enzymes capable to catalyze reactions of transglycosylation. It catalyzed transfer of glyconic part of substrate molecule on methyl-β-D-xylopyranoside, glycerol and methyl-α-D-glucopyranoside. The enzyme can be used in structure determination of β-1,3-glucans (or mixed 1,3;1,4- and 1,3;1,6-β-D-glucans) and enzymatic synthesis of new carbohydrate-containing compounds.

  10. Gravity wave and tidal structures between 60 and 140 km inferred from space shuttle reentry data

    NASA Technical Reports Server (NTRS)

    Fritts, David C.; Wang, Ding-Yi; Blanchard, Robert C.

    1993-01-01

    This study presents an analysis of density measurements made using high-resolution accelerometers aboard several space shuttles at altitudes from 60 to 140 km during reentry into the earth's atmosphere. The observed density fluctuations are interpreted in terms of gravity waves and tides and provide evidence of the importance of such motions well into the thermosphere. Height profiles of fractional density variance reveal that wave amplitudes increase at a rate consistent with observations at lower levels up to about 90 km. The rate of amplitude growth decreases at greater heights, however, and appears to cease above about 110 km. Wave amplitudes are nevertheless large at these heights and suggest that gravity waves may play an important role in forcing of the lower thermosphere.

  11. Daytime vertical and zonal velocities from 150-km echoes: Their relevance to F-region dynamics

    NASA Astrophysics Data System (ADS)

    Chau, Jorge L.; Woodman, Ronald F.

    2004-09-01

    As it was suggested by Kudeki and Fawcett [1993], and later shown by Woodman and Villanueva [1995], vertical Doppler velocities of daytime 150-km echoes represent the vertical E × B drift velocities at F region altitudes. Recently a special experiment was conducted to compare not only the vertical but also the zonal velocities from 150-km echoes with those from an incoherent scatter radar (ISR) mode perpendicular to the magnetic field. The vertical velocity comparisons show that (1) there is a very good agreement between 150-km velocity and the mean F-region E × B drift, and (2) much better agreement is found with the extrapolated values from the ISR altitudinal profiles. On the other hand poor-to-good agreement is found between their zonal components. Our preliminary zonal velocity results, indicate that there is a poor agreement before noontime, while better agreement is found in the afternoon.

  12. Mantle seismic anisotropy beneath the 660km phase transition generated by subduction body force stresses.

    NASA Astrophysics Data System (ADS)

    Nippress, S.; Kusznir, N. J.; Kendall, M.

    2003-04-01

    Observations of seismic anisotropy can provide insights into the style of mantle dynamics near the 660km discontinuity. Wookey et al. (2002) report up to 7 seconds of shear wave splitting for rays generated by deep focus events from the Tonga subduction zone and recorded in Australia. The results suggest a transversely isotropic symmetry with the symmetry axis in the vertical plane, perpendicular to the ray direction. Thus, for horizontally travelling waves this would imply horizontally polarised shear waves (SH lead SV). They show that a topmost lower mantle model with anisotropy between 660-900km could produce theoretical shear wave splitting similar to that observed. Therefore, the seismic anisotropy observed by Wookey et al., can be explained by an anisotropic region between 660-900km, with only a minimal contribution from above the 660km phase transition. The goal of this study is to try to explain the observed shear wave splitting using geodynamical modelling. We use finite element (FE) modelling to calculate slab-induced models of fluid flow, total stress and deviatoric stress. A simple 2D subduction zone model with a prescribed viscosity structure and slab density is used. Large deviatoric stresses (maximum values ~ 40 MPa) are generated in the topmost lower mantle when the subducting slab encounters an increase in viscosity at the 660km phase transition. These stresses may induce mineral alignment in a broad region (lateral wavelength approximately » 800km) in the topmost lower mantle below the slab. Perovskite may therefore be aligned with a rotated symmetry axis conformal to the shape of this region of high deviatoric stress. Aligned Perovskite rotated more than 30 degrees predicts SH-waves faster than SV-waves for horizontally travelling S-waves. The formulation of McKenzie (1979) is used to calculate the finite strain accumulated by a mantle parcel as it propagates through the FE flow models. The computed strain ellipsoids align in a similar region

  13. Status of the central logic board (CLB) of the KM3NeT neutrino telescope

    NASA Astrophysics Data System (ADS)

    Calvo, D.; Real, D.

    2015-12-01

    The KM3NeT collaboration aims at the construction of a multi-km3 high-energy neutrino telescope in the Mediterranean Sea consisting of thousands of glass spheres, each of them containing 31 photomultiplier of small photocathode area. The readout and data acquisition system of KM3NeT has to collect, treat and send to shore, the enormous amount of data produced by the photomultipliers, the acoustics sensor and the rest of the instrumentation. The electronics design includes a multiboot module which allows for the re-configuration of the nodes of the telescope remotely from the shore station. All the modules and subsystems are controlled by two embedded microprocessors, implemented on a Kintetx-7 FPGA, and complex embedded software.

  14. Acoustic neutrino detection investigations within ANTARES and prospects for KM3NeT

    NASA Astrophysics Data System (ADS)

    Lahmann, Robert

    2016-04-01

    The acoustic neutrino detection technique is a promising approach for future large-scale detectors with the aim of measuring the small expected flux of cosmogenic neutrinos at energies exceeding 1 EeV. It suggests itself to investigate this technique in the context of underwater Cherenkov neutrino telescopes, in particular KM3NeT, because acoustic sensors are present by design to allow for the calibration of the positions of the optical sensors. For the future, the KM3NeT detector in the Mediterranean Sea will provide an ideal infrastructure for a dedicated array of acoustic sensors. In this presentation results from the acoustic array AMADEUS of the ANTARES detector will be discussed with respect to the potential and implications for acoustic neutrino detection with KM3NeT and beyond.

  15. Gravity wave and tidal structures between 60 and 140 km inferred from space shuttle reentry data

    SciTech Connect

    Fritts, D.C. ); Dingyi Wang ); Blanchard, R.C. )

    1993-03-15

    This study presents an analysis of density measurements made using high-resolution accelerometers aboard several space shuttles at altitudes from 60 to 140 km during reentry into the earth's atmosphere. The observed density fluctuations are interpreted in terms of gravity waves and tides and provide evidence of the importance of such motions well into the thermosphere. Height profiles of fractional density variance reveal that wave amplitudes increase at a rate consistent with observations at lower levels up to [approximately]90 km. The rate of amplitude growth decreases at greater heights, however, and appears to cease above [approximately]110 km. Wave amplitudes are nevertheless large at these heights and suggest that gravity waves may play an important role in forcing of the lower thermosphere.

  16. AmeriFlux BR-Sa1 Santarem-Km67-Primary Forest

    SciTech Connect

    Saleska, Scott

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site BR-Sa1 Santarem-Km67-Primary Forest. Site Description - The LBA Tapajos KM67 Mature Forest site is located in the Tapajos National Forest, a 450,000 ha closed-canopy upland forest in Amazonian Brazil. Bounded by the Tapajos River in the west and highway BR-163 to the east, the tower is located on a flat plateau (or planalto) that extends up to 150 km to the north, south, and east. Within the confines of the National Forest, anthropogenic disturbances are limited to a few small hunting trails. The surrounding stand is classified as primary or "old-growth"" predominantly by its uneven age distribution, emergent trees, numerous epiphytes and abundant large logs. In 2007 falling trees hit the tower guy wires rendering all instrumentation in-operational. After a complete restoration tower measurements resumed in August of 2008.

  17. Monthly mean global climatology of temperature, wind, geopotential height and pressure for 0-120 km

    NASA Technical Reports Server (NTRS)

    Chandra, Sushil; Schoeberl, Mark R.; Fleming, Eric L.; Barnett, John J.

    1990-01-01

    This paper presents a monthly mean climatology of zonal mean temperature, zonal wind, and geopotential height with nearly pole-to-pole coverage (80 deg S-80 deg N) for 0-120 km which can be used as a function of altitude and pressure. This climatology reproduces most of the characteristic features of the atmosphere such as the lowering and cooling of the mesopause and the lowering and warming of the stratopause during the summer months at high latitudes. A series of zonal wind profiles is also presented comparing this climatological wind with monthly mean climatological direct wind measurements in the upper mesosphere and lower thermosphere. The two data sets compare well below 80 km, with some general seasonal trend agreement observed above 80 km. The zonal wind at the equator presented here simulates the observed features of the semiannual oscillation in the upper stratosphere and mesosphere.

  18. Time-division multiplexing-based BOTDA over 100 km sensing length.

    PubMed

    Dong, Yongkang; Chen, Liang; Bao, Xiaoyi

    2011-01-15

    We propose and demonstrate a high-performance and long-range Brillouin optical time-domain analysis (BOTDA) based on time-division multiplexing measurement, where a probe pulse and a pump pulse are used to perform the measurement on a selected sensing section, and the measurement of the entire sensing fiber is realized by combining the series measurements over different sections through changing the delay time between the two pulses. In experiment, a 100 km sensing fiber is divided into 11 sections based on the gain-controlled principle, and spatial resolutions of 0.6 m and 2 m are obtained at the end of 75 km and 100 km, respectively.

  19. Structure and Electrochemistry of LiNi1/3Co1/3-yMyMn1/3O2 (M=Ti, Al, Fe) Positive Electrode Materials

    SciTech Connect

    Wilcox, James; Patoux, Sebastien; Doeff, Marca

    2009-01-14

    A series of materials based on the LiNi1/3Co1/3-yMyMn1/3O2 (M = Ti,Al,Fe) system has been synthesized and examined structurally and electrochemically. It is found that the changes in electrochemical performance depend highly on the nature of the substituting atom and its effect on the crystal structure. Substitution with small amounts of Ti4+ (y = 1/12) leads to the formation of a high-capacity and high-rate positive electrode material. Iron substituted materials suffer from an increased antisite defect concentration and exhibit lower capacities and poor rate capabilities. Single-phase materials are found for LiNi1/3Co1/3-yAlyMn1/3O2 when y<_ 1/4 and all exhibit decreased capacities when cycled to 4.3 V. However, an increase in rate performance and cycle stability upon aluminum substitution is correlated with an improved lamellar structure.

  20. Microstructural investigation of LixNi1/3Mn1/3Co1/3O2 (x 1) and its aged products via magnetic and diffraction study

    SciTech Connect

    Mohanty, Debasish; Gabrisch, Heike

    2012-01-01

    The thermal stability of the layered oxide LiNi1/3Mn1/3Co1/3O2 and its delithiated product is studied by a combination of x-ray and electron diffraction, TEM imaging and magnetic measurements. Diffraction shows that a small fraction of the layered material converts to spinel phase following delithiation. More spinel phase is observed after thermal annealing. The morphology of the particle changes upon thermal annealing of delithiated materials. The selected area electron diffraction and the magnetic measurement results confirm the presence of Ni+2/Li+ disorder in the delithiated material, which increases upon thermal ageing. The oxidation states of the transition metal ions were determined from magnetic data. It is shown that the charge balance due TO removal of Li+ is maintained through oxidation of Ni+2 and that the oxidation states remain stable during subsequent annealing. No anti-ferromagnetic ordering or crystallographic in plane ordering of transition metal ions is observed. These results clearly describe the thermal degradation of LixNi1/3Mn1/3Co1/3O2 (x 1) occur through the significant microstructural changes.

  1. Comparison of turbulence-induced scintillations for multi-wavelength laser beacons over tactical (7 km) and long (149 km) atmospheric propagation paths

    NASA Astrophysics Data System (ADS)

    Vorontsov, M.; Gudimetla, V.; Carhart, G.; Weyrauch, T.; Lachinova, S.; Polnau, E.; Reierson, J.; Beresnev, L.; Liu, J.; Riker, J.

    2011-09-01

    We report results of the experimental analysis of atmospheric effects on laser beam propagation over two distinctive propagation paths: a long-range (149 km) propagation path between Mauna Loa (Island of Hawaii) and Haleakala (Island of Maui) mountains, and a tactical-range (7 km) propagation path between the roof of the Dayton Veterans Administration Medical Center (VAMC) and the Intelligent Optics Laboratory (IOL/UD) located on the 5th floor of the University of Dayton College Park Center building. Both testbeds include three laser beacons operating at wavelengths 532 nm, 1064 nm, and 1550 nm and a set of identical optical receiver systems with fast-framing IR cameras for simultaneous measurements of pupil and focal plane intensity distributions. The results reported here are focused on analysis of intensity scintillations that were simultaneously measured at three wavelengths. Comparison of experimental results shows significant differences in the physics of atmospheric turbulence impact on laser beam propagation over the long- and tactical-range distances.

  2. On the origin of 150-km echoes: Recent observational results and current understanding

    NASA Astrophysics Data System (ADS)

    Patra, Amit

    2012-07-01

    Discovered nearly 45 years ago, the so-called 150-km echoing phenomenon continues to be a puzzle. These are the coherent radar echoes coming from the height region of 140-180 km during daytime and are of special interest to the ionospheric scientists since they are very useful means for estimating the daytime electric fields, a crucial parameter for studying daytime electrodynamics and plasma physics, and can be observed by radar with moderate sensitivity. Although the 150-km echoes are being regularly used for studying low latitude electrodynamics, it is a bit awkward using them in the scientific work without knowing their origin. This paper is meant to present and discuss new results obtained from Gadanki (13.5o N, 79.2o E, mag. lat. 6.5o N), India to elucidate the underlying physical processes, not considered before. Two new findings, one obtained during the passage of a solar eclipse and another linked with the intermediate layer type descending properties of 150-km echoes, clearly indicate the role of electron density gradient in generating the irregularities responsible for the 150-km radar echoes, not envisioned before. Given the fact that Gadanki is located at magnetically low latitude, it is proposed that the descending echoing layers are produced by interchange instability on the gradient of daytime descending ion layer formed by meridional wind shear associated with tidal/gravity waves quite similar to that observed during nighttime. Comparative anatomy of daytime 150-km echoes and nighttime intermediate layer echoes will also be presented and discussed in an effort to have a deeper understanding on the underlying instability processes.

  3. Influence of an Enforced Fast Start on 10-km-Running Performance.

    PubMed

    do Carmo, Everton C; Barroso, Renato; Renfree, Andrew; Gil, Saulo; Tricoli, Valmor

    2016-09-01

    The effects of an enforced fast start on long-distance performance are controversial and seem to depend on the athlete's capacity to delay and tolerate metabolic disruption. The aim of this study was to investigate the effects of an enforced start on 10-km-running performance and the influence of the some physiological and performance variables on the ability to tolerate an enforced fast start during the running. Fifteen moderately trained runners performed two 10-km time trials (TTs): free pacing (FP-TT) and fast start (FS-TT). During FS-TT, speed during the first kilometer was 6% higher than in FP-TT. Maximal oxygen uptake (VO2max), peak velocity (PV), velocity associated with VO2max (vVO2max), ventilatory threshold, and running economy at 10 and 12 km/h and FP-TT average velocity (AV-10 km) were individually determined. There were no differences between FP-TT and FS-TT performance (45:01 ± 4:08 vs 45:11 ± 4:46 min:s, respectively, P = .4). Eight participants improved (+2.2%) their performance and were classified as positive responders (PR) and 7 decreased (-3.3%) performance and were classified as negative responders (NR). Running speed was significantly higher for PR between 6 and 9.2 km (P < .05) during FS-TT. In addition, PR presented higher PV (P = .02) and vVO2max (P = .01) than NR, suggesting that PV and vVO2max might influence the ability to tolerate a fast-start strategy. In conclusion, there was an individual response to the enforced fast-start strategy during 10-km running, and those who improved performance also presented higher vVO2max and PV, suggesting a possible association between these variables and response to the strategy adopted.

  4. Effects of 200 km propagation on Florida lightning return stroke electric fields

    NASA Technical Reports Server (NTRS)

    Uman, M. A.; Swanberg, C. E.; Tiller, J. A.; Lin, Y. T.; Krider, E. P.

    1976-01-01

    The electric fields produced by lightning return strokes near Kennedy Space Center, Florida, have been measured simultaneously at distances of about 5 to 25 km and about 200 km. Detailed records of the first 12 microsec of waveforms from four strokes are presented, as well as data on the initial field risetimes for 58 first and 92 subsequent strokes. The mean field risetime measured between the 10 to 90% points was about 1 microsec at the close station and about 2 microsec at the distant one.

  5. LES Modeling of Lateral Dispersion in the Ocean on Scales of 10 m to 10 km

    DTIC Science & Technology

    2015-10-20

    Report 3. DATES COVERED (From - To) 01/07/2010 – 06/06/2015 4. TITLE AND SUBTITLE LES Modeling of Lateral Dispersion in the Ocean on Scales of 10...ocean on scales of 0.1-10 km that can be implemented in larger- scale ocean models. These parameterizations will incorporate the effects of local...Distribution approved for public release; distribution is unlimited. Final Report LES Modeling of Lateral Dispersion on Scales of 10 m to 10 km M.-Pascale

  6. One kilometer (1 km) electric solar wind sail tether produced automatically.

    PubMed

    Seppänen, Henri; Rauhala, Timo; Kiprich, Sergiy; Ukkonen, Jukka; Simonsson, Martin; Kurppa, Risto; Janhunen, Pekka; Hæggström, Edward

    2013-09-01

    We produced a 1 km continuous piece of multifilament electric solar wind sail tether of μm-diameter aluminum wires using a custom made automatic tether factory. The tether comprising 90,704 bonds between 25 and 50 μm diameter wires is reeled onto a metal reel. The total mass of 1 km tether is 10 g. We reached a production rate of 70 m/24 h and a quality level of 1‰ loose bonds and 2‰ rebonded ones. We thus demonstrated that production of long electric solar wind sail tethers is possible and practical.

  7. Results and simulation of the prototype detection unit of KM3NeT-ARCA

    NASA Astrophysics Data System (ADS)

    Hugon, C. M. F.

    2017-03-01

    KM3NeT-ARCA is a deep sea high energy neutrino detector. A detection unit prototype was deployed in the future KM3NeT-ARCA deep-sea site, off of the Sicilian coast. This detection unit is composed of a line of 3 digital optical modules with 31 photomultiplier tubes on each one. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. The results of the calibration of this detection unit and its simulation are presented and discussed.

  8. KM3NeT - ORCA: measuring the neutrino mass ordering in the Mediterranean

    NASA Astrophysics Data System (ADS)

    Kouchner, Antoine

    2016-05-01

    ORCA (Oscillations Research with Cosmics in the Abyss) is the low-energy branch of KM3NeT, the underwater Cherenkov neutrino detector in the Mediterranean. Its primary goal is to resolve the long-standing unsolved question of the neutrino mass ordering by measuring matter oscillation effects in atmospheric neutrinos. To be deployed at the French KM3NeT site, ORCA’s multi-PMT optical modules will exploit the excellent optical properties of deep seawater to reconstruct cascade and track events with a few GeV of energy. This contribution reviews the methods and technology, and discusses the current expected performances.

  9. Appraising the reliability of converted wavefield imaging: application to USArray imaging of the 410-km discontinuity

    NASA Astrophysics Data System (ADS)

    Liu, Xin; Pavlis, Gary L.

    2013-03-01

    We develop a generic method to appraise the reliability of wavefield imaging methods and use it to validate some novel observations on the 410-km discontinuity. The core concept of the error appraisal method is to produce a simulated data set that replicates the geometry of the real data. Here we implemented two simulation methods: (1) flat layer primary P to S conversions, and (2) a point source scattering model for P to S conversion data based on the Born approximation and ray theory propagators. We show how the approach can be extended for any simulation algorithm. We apply this new approach to appraise recent results using a 3-D, three-component P to S conversion imaging method applied to data collected by the USArray. Multiple metrics show that the amplitude of P to S converted energy scattered from the 410-km discontinuity varies by 18 dB with a systematically lower amplitude in an irregular band running from Idaho through northern Arizona. In addition, we observe strong lateral changes in the ratio of amplitudes recovered on the radial versus the transverse component. We compute point resolution functions and a checkerboard test to demonstrate we can reliably recover relative amplitudes with a lateral scale of the order of 200 km and a vertical scale of approximately 10 km. Irregular coverage locally distorts the amplitudes recovered in the checkerboard, but a 156 km scale checkerboard pattern is recovered. Flat layer simulations show we can recover relative amplitudes to within a range of 1 dB and the reconstructed transverse to radial amplitude is everywhere less than 0.1. A model with north-south oriented ridges with a 3° wavelength and 12.5 km amplitude shows of the order of ±6 dB amplitude variations and small, but clear correlation of the transverse/radial amplitude ratio topography in the model. Finally, we model the 410-km discontinuity as a rough surface characterized by variations in amplitude and depth derived from the USArray data. The rough

  10. Configuration Management (CM) Support for KM Processes at NASA/Johnson Space Center (JSC)

    NASA Technical Reports Server (NTRS)

    Cioletti, Louis

    2010-01-01

    Collection and processing of information are critical aspects of every business activity from raw data to information to an executable decision. Configuration Management (CM) supports KM practices through its automated business practices and its integrated operations within the organization. This presentation delivers an overview of JSC/Space Life Sciences Directorate (SLSD) and its methods to encourage innovation through collaboration and participation. Specifically, this presentation will illustrate how SLSD CM creates an embedded KM activity with an established IT platform to control and update baselines, requirements, documents, schedules, budgets, while tracking changes essentially managing critical knowledge elements.

  11. Effects of biochar on the emissions, soil distribution, and nematode control of 1,3-dichloropropene

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Application of a rice husk-derived biochar to the surface of a sandy loam soil chamber reduced soil-air emissions of 1,3-dichloropropene (1,3-D) from 42% in a control (no biochar) to 8%. The difference in emissions was due to adsorption of 1,3-D onto the biochar, measured as 32.5%. The remaining 1,3...

  12. 1,1',4,5-tetrahydrotrispiro[1,3,2-diazaphosphole-2,2'-[1,3,5,2,4,6]triazatriphosphinine-4',6''-dibenzo[d,f][1,3,2]dioxaphosphepine-6',6'''-dibenzo[d,f][1,3,2]dioxaphosphepine

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The title compound 1,1',4,5-tetrahydrotrispiro[1,3,2-diazaphosphole-2,2'-[1,3,5,2,4,6]triazatriphosphinine-4',6''-dibenzo[d,f][1,3,2]dioxaphosphepine-6',6'''-dibenzo[d,f][1,3,2]dioxaphosphepine], C26H22N5O4P3, at 100°K has monoclinic (P21/c) symmetry and is achieved in a two step synthesis that does...

  13. Wide-Field Plate Database

    NASA Astrophysics Data System (ADS)

    Tsvetkov, M. K.; Stavrev, K. Y.; Tsvetkova, K. P.; Semkov, E. H.; Mutatov, A. S.

    The Wide-Field Plate Database (WFPDB) and the possibilities for its application as a research tool in observational astronomy are presented. Currently the WFPDB comprises the descriptive data for 400 000 archival wide field photographic plates obtained with 77 instruments, from a total of 1 850 000 photographs stored in 269 astronomical archives all over the world since the end of last century. The WFPDB is already accessible for the astronomical community, now only in batch mode through user requests sent by e-mail. We are working on on-line interactive access to the data via INTERNET from Sofia and parallel from the Centre de Donnees Astronomiques de Strasbourg. (Initial information can be found on World Wide Web homepage URL http://www.wfpa.acad.bg.) The WFPDB may be useful in studies of a variety of astronomical objects and phenomena, andespecially for long-term investigations of variable objects and for multi-wavelength research. We have analysed the data in the WFPDB in order to derive the overall characteristics of the totality of wide-field observations, such as the sky coverage, the distributions by observation time and date, by spectral band, and by object type. We have also examined the totality of wide-field observations from point of view of their quality, availability and digitisation. The usefulness of the WFPDB is demonstrated by the results of identification and investigation of the photometrical behaviour of optical analogues of gamma-ray bursts.

  14. Improved 1,3-propanediol production with hemicellulosic hydrolysates (corn straw) as cosubstrate: Impact of degradation products on Klebsiella pneumoniae growth and 1,3-propanediol fermentation.

    PubMed

    Jin, Pin; Li, Shuang; Lu, Sheng-guo; Zhu, Jian-guo; Huang, He

    2011-01-01

    To improve 1,3-propanediol (1,3-PD) production by an economic and efficient approach, hemicellulosic hydrolysates (HH) used as cosubstrate resulted in more biomass and higher reducing power for 1,3-PD production. The effects of primary degradation products such as individual sugars (xylose, glucose, mannose, arabinose and galactose) and major inhibitors (furfural, acetate and formate) on the Klebsiella pneumoiae growth and 1,3-PD production were investigated in this study. Xylose and mannose could efficiently promote the 1,3-PD production and cell growth. Furfural (0.28 g/l) and sodium acetate (1.46 g/l) in low concentration were not inhibitory to Klebsiella pneumoniae, rather they have stimulatory effect on the growth and 1,3-PD biosynthesis, especially the acetate. In fed-batch fermentation with HH as cosubstrate, the final 1,3-PD production, conversion from glycerol and productivity were 71.58 g/l, 0.65 mol/mol and 1.93 g/l/h, respectively, which were 17.8%, 25.0% and 17.7% higher than that from glycerol alone.

  15. Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate.

    PubMed

    Yang, Seung-Ju; Lee, Seok-Hyeong; Kwak, Hyun-Jung; Gong, Young-Dae

    2013-01-18

    A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-methyl-2-pyrrolidone to give the corresponding 2-amino-1,3,4-oxadiazoles 4 and 2-amino-1,3,4-thiadiazoles 5 through regioselcective cyclization processes. The regioselectivity was affected by both R(1) and R(2) in p-TsCl mediated cyclization. It is shown in select sets of thiosemicarbazide 3 with R(1)(benzyl) and R(2)(phenyl). 2-Amino-1,3,4-oxadiazole 4 was also shown in the reaction of p-TsCl mediated cyclization. The resulting 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeleton are functionalized with various electrophiles such as alkyl halide, acid halides, and sulfornyl chloride in high yields.

  16. San Andres Rift, Nicaraguan Shelf: A 346-Km-Long, North-South Rift Zone Actively Extending the Interior of the "Stable" Caribbean Plate

    NASA Astrophysics Data System (ADS)

    Carvajal, L. C.; Mann, P.

    2015-12-01

    The San Andres rift (SAR) is an active, 015°-trending, bathymetric and structural rift basin that extends for 346 km across the Nicaraguan platform and varies in bathymetric width from 11-27 km and in water depth from 1,250 to 2,500 m. We used four 2D regional seismic lines tied to two offshore, industry wells located west of the SAR on the Nicaraguan platform to map normal faults, transfer faults, and possibly volcanic features with the rift. The Colombian islands of San Andres (26 km2) and Providencia (17 km2) are footwall uplifts along west-dipping, normal fault bounding the eastern margin of the rift. Mapping indicates the pre-rift section is Late Cretaceous to Oligocene in age and that the onset of rifting began in the early to middle Miocene as shown by wedging of the Miocene and younger sedimentary fill controlled by north-south-striking normal faults. Structural restorations at two locations across the rift shows that the basin opened mainly by dip-slip fault motions producing a total, east-west extension of 18 km in the north and 15 km in the south. Structural restoration shows the rift formed on a 37-km-wide, elongate basement high - possibly of late Cretaceous, volcanic origin and related to the Caribbean large igneous province. Previous workers have noted that the SAR is associated with province of Pliocene to Quaternary seamounts and volcanoes which range from non-alkaline to mildly alkaline, including volcanic rocks on Providencia described as andesites and rhyolites. The SAR forms one of the few recognizable belts of recorded seismicity within the Caribbean plate. The origin of the SAR is related to Miocene and younger left-lateral displacement along the Pedro Banks fault to the north and the southwestern Hess fault to the south. We propose that the amount of left-lateral displacement that created the rift is equivalent to the amount of extension that formed it: 18-20 km.

  17. Health Assessment Document for 1,3-Butadiene (External Review Draft)

    EPA Science Inventory

    This risk assessment of 1,3-butadiene, a gas used commercially in the production of various resins and plastics, concludes that 1,3-butadiene is a known human carcinogen, based on three types of evidence: 1) excess leukemias in workers occupationally exposed to 1,3-butadiene (by ...

  18. 26 CFR 36.3121(l)(1)-3 - Effect of agreement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Effect of agreement. 36.3121(l)(1)-3 Section 36.3121(l)(1)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... SUBSIDIARIES § 36.3121(l)(1)-3 Effect of agreement. (a) Liability for amounts equivalent to tax—(1) In...

  19. 26 CFR 36.3121(l)(1)-3 - Effect of agreement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 15 2012-04-01 2012-04-01 false Effect of agreement. 36.3121(l)(1)-3 Section 36.3121(l)(1)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... SUBSIDIARIES § 36.3121(l)(1)-3 Effect of agreement. (a) Liability for amounts equivalent to tax—(1) In...

  20. 26 CFR 36.3121(l)(1)-3 - Effect of agreement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Effect of agreement. 36.3121(l)(1)-3 Section 36.3121(l)(1)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... SUBSIDIARIES § 36.3121(l)(1)-3 Effect of agreement. (a) Liability for amounts equivalent to tax—(1) In...

  1. 26 CFR 36.3121(l)(1)-3 - Effect of agreement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Effect of agreement. 36.3121(l)(1)-3 Section 36.3121(l)(1)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... SUBSIDIARIES § 36.3121(l)(1)-3 Effect of agreement. (a) Liability for amounts equivalent to tax—(1) In...

  2. 26 CFR 36.3121(l)(1)-3 - Effect of agreement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Effect of agreement. 36.3121(l)(1)-3 Section 36.3121(l)(1)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... SUBSIDIARIES § 36.3121(l)(1)-3 Effect of agreement. (a) Liability for amounts equivalent to tax—(1) In...

  3. 40 CFR 80.55 - Measurement methods for benzene and 1,3-butadiene.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Measurement methods for benzene and 1... Measurement methods for benzene and 1,3-butadiene. (a) Sampling for benzene and 1,3-butadiene must be... 86.109. (b) Benzene and 1,3-butadiene must be analyzed by gas chromatography. Expected values...

  4. 40 CFR 80.55 - Measurement methods for benzene and 1,3-butadiene.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Measurement methods for benzene and 1... Measurement methods for benzene and 1,3-butadiene. (a) Sampling for benzene and 1,3-butadiene must be... 86.109. (b) Benzene and 1,3-butadiene must be analyzed by gas chromatography. Expected values...

  5. 40 CFR 80.55 - Measurement methods for benzene and 1,3-butadiene.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Measurement methods for benzene and 1... Measurement methods for benzene and 1,3-butadiene. (a) Sampling for benzene and 1,3-butadiene must be... 86.109. (b) Benzene and 1,3-butadiene must be analyzed by gas chromatography. Expected values...

  6. 40 CFR 80.55 - Measurement methods for benzene and 1,3-butadiene.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Measurement methods for benzene and 1... Measurement methods for benzene and 1,3-butadiene. (a) Sampling for benzene and 1,3-butadiene must be... 86.109. (b) Benzene and 1,3-butadiene must be analyzed by gas chromatography. Expected values...

  7. 40 CFR 80.55 - Measurement methods for benzene and 1,3-butadiene.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Measurement methods for benzene and 1... Measurement methods for benzene and 1,3-butadiene. (a) Sampling for benzene and 1,3-butadiene must be... 86.109. (b) Benzene and 1,3-butadiene must be analyzed by gas chromatography. Expected values...

  8. 40 CFR 721.10162 - 1,3 Dioxolane-4-butanol, 2-ethenyl-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 1,3 Dioxolane-4-butanol, 2-ethenyl... Specific Chemical Substances § 721.10162 1,3 Dioxolane-4-butanol, 2-ethenyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1,3 dioxolane-4-butanol,...

  9. 40 CFR 721.10162 - 1,3 Dioxolane-4-butanol, 2-ethenyl-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 1,3 Dioxolane-4-butanol, 2-ethenyl... Specific Chemical Substances § 721.10162 1,3 Dioxolane-4-butanol, 2-ethenyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1,3 dioxolane-4-butanol,...

  10. 40 CFR 721.10162 - 1,3 Dioxolane-4-butanol, 2-ethenyl-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 1,3 Dioxolane-4-butanol, 2-ethenyl... Specific Chemical Substances § 721.10162 1,3 Dioxolane-4-butanol, 2-ethenyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1,3 dioxolane-4-butanol,...

  11. 40 CFR 721.10162 - 1,3 Dioxolane-4-butanol, 2-ethenyl-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 1,3 Dioxolane-4-butanol, 2-ethenyl... Specific Chemical Substances § 721.10162 1,3 Dioxolane-4-butanol, 2-ethenyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1,3 dioxolane-4-butanol,...

  12. 40 CFR 721.10162 - 1,3 Dioxolane-4-butanol, 2-ethenyl-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 1,3 Dioxolane-4-butanol, 2-ethenyl... Specific Chemical Substances § 721.10162 1,3 Dioxolane-4-butanol, 2-ethenyl-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 1,3 dioxolane-4-butanol,...

  13. 30 CFR 1.3 - Use of letters and acronym MSHA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...

  14. 30 CFR 1.3 - Use of letters and acronym MSHA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...

  15. 30 CFR 1.3 - Use of letters and acronym MSHA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...

  16. 30 CFR 1.3 - Use of letters and acronym MSHA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...

  17. 30 CFR 1.3 - Use of letters and acronym MSHA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Use of letters and acronym MSHA. 1.3 Section 1.3 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OFFICIAL EMBLEM AND...; ESTABLISHMENT AND USE OF OFFICIAL EMBLEM § 1.3 Use of letters and acronym MSHA. The letters and acronym MSHA...

  18. 40 CFR 721.10280 - Benzene ethenyl-, polymer with 1,3-butadiene, brominated.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Benzene ethenyl-, polymer with 1,3... Specific Chemical Substances § 721.10280 Benzene ethenyl-, polymer with 1,3-butadiene, brominated. (a... benzene ethenyl-, polymer with 1,3-butadiene, brominated (PMN P-10-476; CAS No. 1195978-93-8)) is...

  19. 40 CFR 721.10280 - Benzene ethenyl-, polymer with 1,3-butadiene, brominated.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Benzene ethenyl-, polymer with 1,3... Specific Chemical Substances § 721.10280 Benzene ethenyl-, polymer with 1,3-butadiene, brominated. (a... benzene ethenyl-, polymer with 1,3-butadiene, brominated (PMN P-10-476; CAS No. 1195978-93-8)) is...

  20. 8 CFR 1.3 - Lawfully present aliens for purposes of applying for Social Security benefits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... applying for Social Security benefits. 1.3 Section 1.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY GENERAL PROVISIONS DEFINITIONS § 1.3 Lawfully present aliens for purposes of applying for Social... one of the following classes of aliens permitted to remain in the United States because DHS...