Science.gov

Sample records for 1-4 mw proton

  1. Project X: A Multi-MW Proton Source at Fermilab

    SciTech Connect

    Holmes, Stephen D.; /Fermilab

    2010-05-01

    As the Fermilab Tevatron Collider program draws to a close a strategy has emerged of an experimental program built around the high intensity frontier. The centerpiece of this program is a superconducting H- linac that will support world leading programs in long baseline neutrino experimentation and he study of rare processes. Based on technology shared with the International Linear Collider (ILC), Project X will provide multi-MW beams at 60-120 GeV from the Main Injector, simultaneous with very high intensity beams at lower energies. Project X will also support development of a Muon Collider as a uture facility at the energy frontier.

  2. A 10-GeV, 5-MW proton source for a muon-muon collider

    SciTech Connect

    Cho, Y.; Chae, Y.; Crosbie, E.; Friedsam, H.; Harkay, K.; Horan, D.; Kustom, R.; Lessner, E.; McDowell, W.; McGhee, D.; Moe, H.; Nielsen, R.; Norek, G.; Peterson, K.; Qian, Y.; Thompson, K.; White, M.

    1996-05-01

    The performance parameters of a proton source which produces the required flux of muons for a 2-TeV on 2-TeV muon collider are: a beam energy of 10 GeV, a repetition rate of 30 Hz, two bunches per pulse with 5{times}10{sup 13} protons per bunch, and an rms bunch length of 3 nsec (1). Aside from the bunch length requirement, these parameters are identical to those of a 5-MW proton source for a spallation neutron source based on a 10-GeV rapid cycling synchrotron (RCS) (2). The 10-GeV synchrotron uses a 2-GeV accelerator system as its injector, and the 2-GeV RCS is an extension of a feasibility study for a 1-MW spallation source described elsewhere (3{endash}9). A study for the 5-MW spallation source was performed for ANL site-specific geometrical requirements. Details are presented for a site-independent proton source suitable for the muon collider utilizing the results of the 5-MW spallation source study. {copyright} {ital 1996 American Institute of Physics.}

  3. Beam Loss Studies for the 2-MW LBNE Proton Beam Line

    SciTech Connect

    Drozhdin, A.I.; Childress, S.R.; Mokhov, N.V.; Tropin, I.S.; Zwaska, R.; /Fermilab

    2012-05-01

    Severe limits are put on allowable beam loss during extraction and transport of a 2.3 MW primary proton beam for the Long Baseline Neutrino Experiment (LBNE) at Fermilab. Detailed simulations with the STRUCT and MARS codes have evaluated the impact of beam loss of 1.6 x 10{sup 14} protons per pulse at 120 GeV, ranging from a single pulse full loss to sustained small fractional loss. It is shown that loss of a single beam pulse at 2.3 MW will result in a catastrophic event: beam pipe destruction, damaged magnets and very high levels of residual radiation inside and outside the tunnel. Acceptable beam loss limits have been determined and robust solutions developed to enable efficient proton beam operation under these constraints.

  4. Protonation of anion intermediates in metal-ammonia reduction: 1,2- vs 1,4-dihydro aromatic products

    SciTech Connect

    Rabideau, P.W.; Huser, D.L.

    1983-11-18

    The competition between 1,3-cyclohexadienes and 1,4-cyclohexadienes during metal-ammonia reduction has been examined. The former is usually regarded as a thermodynamic product and the latter as a kinetic product although, in actuality, little thermodynamic difference exists between these two isomers. 1,4-Cyclohexadiene was found to undergo proton abstraction with potassium or sodium amide in ammonia at -50/sup 0/C but not with lithium amide. Similarly, 1,3-cyclohexadiene reacts only with potassium amide and not with sodium or lithium amide. Consequences relating to the formation of conjugated and nonconjugated products during metal-ammonia reduction are discussed. The reaction of dihydronaphthalenes with various amides is also presented and again there is considerable variation in behavior. This has led to improved synthetic schemes for the selective production of 1,2-dihydro- and 1,4-dihydronaphthalenes as well as tetralins. Finally, protonation sites in pentadienyl type anions are considered. 4 tables.

  5. Protonation of anion intermediates in metal-ammonia reduction: 1,2- vs. 1,4-dihydro aromatic products

    SciTech Connect

    Rabideau, P.W.; Huser, D.L.

    1983-01-01

    The competition between 1,3-cyclohexadienes and 1,4-cyclohexadienes during metal-ammonia reduction has been examined. The former is usually regarded as a thermodynamic product and the latter as a kinetic product although, in actuality, little thermodynamic difference exists between these two isomers. 1,4-Cyclohexadiene was found to undergo proton abstraction with potassium or sodium amide in ammonia at -50/sup 0/C but not with lithium amide. Similarly, 1,3-cyclohexadiene reacts only with potassium amide and not with sodium or lithium amide. Consequences relating to the formation of conjugated and nonconjugated products during metal-ammonia reduction are discussed. The reaction of dihydronaphthalenes with various amides also demonstrates considerable variation in behavior. These experimental results have led to improved synthetic schemes for the selective production of 1,2-dihydro- and 1,4-dihydronaphthalenes as well as tetralins. Finally, protonation sites in pentadienyl type anions are considered.

  6. Vibrational signatures of hydrogen bonding in the protonated ammonia clusters NH4+(NH3)1-4

    NASA Astrophysics Data System (ADS)

    Yang, Y.; Kühn, O.; Santambrogio, G.; Goebbert, D. J.; Asmis, K. R.

    2008-12-01

    The gas phase vibrational spectroscopy of the protonated ammonia dimer N2H7+, a prototypical system for strong hydrogen bonding, is studied in the spectral region from 330 to 1650 cm-1 by combining infrared multiple photon dissociation and multidimensional quantum mechanical simulations. The fundamental transition of the antisymmetric proton stretching vibration is observed at 374 cm-1 and assigned on the basis of a six-dimensional model Hamiltonian, which predicts this transition at 471 cm-1. Photodissociation spectra of the larger protonated ammonia clusters NH4+(NH3)n with n =2-4 are also reported for the range from 1050 to 1575 cm-1. The main absorption features can be assigned within the harmonic approximation, supporting earlier evidence that hydrogen bonding in these clusters is considerably weaker than for n =1.

  7. Cross-section for proton tritium scattering from 1.4 to 3.4 MeV at the laboratory angle of 165°

    NASA Astrophysics Data System (ADS)

    Xia, X. J.; Ding, W.; Zhang, B.; Long, X. G.; Luo, S. Z.; Peng, S. M.; Hutton, R.; Shi, L. Q.

    2008-03-01

    The elastic scattering cross-section for proton scattering from tritium was measured at a laboratory angle of 165° and over an incident proton energy range from 1.4 to 3.4 MeV. A thin solid target containing 1.62 × 1017 T atoms/cm2 was prepared by absorption of tritium into a film of titanium on aluminium foil backing. The cross-section increases almost linearly with decreasing energy in the higher energy region of 2-3.4 MeV. The currently measured cross-section data are compared with data available in the literature values and they show a similarly linear trend in a similar higher energy range. The maximum difference in the cross-section at almost the same scattering angle between current data and the previous results is no worse than 2.3%.

  8. Picosecond-nanosecond laser photolysis studies on the photochemical reaction of excited benzophenone with 1,4-diazabicyclo[2.2.2]octane in acetonitrile solution: proton abstraction of the free benzophenone anion radical from the ground state amine

    NASA Astrophysics Data System (ADS)

    Miyasaka, Hiroshi; Morita, Kazuhiro; Kamada, Kenji; Mataga, Noboru

    1991-04-01

    Picosecond and nanosecond dynamics of the ion pair produced by the electron transfer reaction between the triplet state benzophenone ( 3BP*) and 1,4-diazabicyclo[2.2.2]octane (DABCO) was investigated by means of transient absorption spectroscopy and laser-induced photoconductivity measurement. It has been revealed that the solvated free anion radical of BP, produced by the rapid ionic dissociation of the ion pair within 2 ns, abstracts proton from the neutral DABCO giving benzophenone ketyl radical, competing with the charge recombination reaction at encounter with DABCO +, decomposition and/or impurity scavenging processes.

  9. Syntheses, structures and properties of two cadmium compounds containing neutral or in situ protonized 1,4-diazabicyclo[2.2.2]octane

    NASA Astrophysics Data System (ADS)

    Wang, Xiao-Feng; Qi, Xiao-Lin; Shi, Fa-Nian; Rocha, João

    2011-10-01

    Reaction of Cd(Ac) 2, 1,4-diazabicyclo[2.2.2]octane (DABCO) and biphenyl-2,2'-dicarboxylic acid or biphenyl-4,4'-dicarboxylic acid, two new cadmium complexes, namely molecular quadrangle [Cd 2(2,2'-BPDC) 2(Ac) 2(DABCOH) 2]·2H 2O ( 1) and one dimension (1-D) chain [Cd(Ac) 2(DABCO)(H 2O)] n·2 nH 2O ( 2), have been synthesized and characterized by elemental analysis, IR spectroscopy and X-ray crystallography. The solution-gel-solution transformation course to crystallize 2 was captured. Through the alternately hydrogen bonds between coordinated Ac - and lattice H 2O, both 1 and 2 give rise to a three-dimensional supramolecular structures. In room temperature, 1 displays intense blue fluorescent emission derived from ligand-to-metal change transfer (LMCT).

  10. Report of the Snowmass M6 Working Group on high intensity proton sources

    SciTech Connect

    Weiren Chou and J. Wei

    2002-08-20

    The U.S. high-energy physics program needs an intense proton source, a 1-4 MW Proton Driver (PD), by the end of this decade. This machine will serve as a stand-alone facility that will provide neutrino superbeams and other high intensity secondary beams such as kaons, muons, neutrons, and anti-protons (cf. E1 and E5 group reports) and also serve as the first stage of a neutrino factory (cf. M1 group report). It can also be a high brightness source for a VLHC. Based on present accelerator technology and project construction experience, it is both feasible and cost-effective to construct a 1-4 MW Proton Driver. Two recent PD design studies have been made, one at FNAL and the other at the BNL. Both designed PD's for 1 MW proton beams at a cost of about U.S. $200M (excluding contingency and overhead) and both designs were upgradeable to 4 MW. An international collaboration between FNAL, BNL and KEK on high intensity proton facilities is addressing a number of key design issues. The superconducting (sc) RF cavities, cryogenics, and RF controls developed for the SNS can be directly adopted to save R&D efforts, cost, and schedule. PD studies are also actively being pursued at Europe and Japan.

  11. Choice of Proton Driver Parameters for a Neutrino Factory

    SciTech Connect

    Kirk,H.G.; Berg, J. S.; Fernow, R. C.; Gallardo, J. C.; Simos, N.; Weng, W.-T.; Brooks, S.

    2006-06-26

    We discuss criteria for designing an optimal 'green field' proton driver for a neutrino factory. The driver parameters are determined by considerations of space charge, power capabilities of the target, beam loading and available RF peak power. A neutrino factory may be the best experimental tool to unravel the physics involved in neutrino oscillation and CP violation phenomena [1]. To have sufficient neutrino flux for acceptable physics results within 5 years requires about 10{sup 22} protons on target per year, which corresponds to 1-4 MW of proton beam power from the proton driver depending on the beam energy. In the past, there were individual proposals from different laboratories of a particular design of proton driver capable of delivering beam power from 2 to 4 MW, without consistent attention paid to the needs or requirements from the downstream systems. In this study, we try to identify the requirements from those down stream systems first, then see whether it is possible to design a proton driver to meet those needs. Such a study will also assist site specific proposals to further improve on their designs to better serve the need of a proton driver for neutrino factory applications.

  12. Proton bunch compression strategies

    SciTech Connect

    Lebedev, Valeri; /Fermilab

    2009-10-01

    The paper discusses main limitations on the beam power and other machine parameters for a 4 MW proton driver for muon collider. The strongest limitation comes from a longitudinal microwave instability limiting the beam power to about 1 MW for an 8 GeV compressor ring.

  13. 1,4-Dioxane

    Integrated Risk Information System (IRIS)

    1,4 - Dioxane ; CASRN 123 - 91 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic Eff

  14. 1,4-Dithiane

    Integrated Risk Information System (IRIS)

    1,4 - Dithiane ; CASRN 505 - 29 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinogenic Ef

  15. 1,4-Dichlorobenzene

    Integrated Risk Information System (IRIS)

    1,4 - Dichlorobenzene ; CASRN 106 - 46 - 7 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinog

  16. 1,4-Dibromobenzene

    Integrated Risk Information System (IRIS)

    1,4 - Dibromobenzene ; CASRN 106 - 37 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcinoge

  17. Four-electron oxidative dehydrogenation induced by proton-coupled electron transfer in ruthenium(III) complex with 2-(1,4,5,6-tetrahydropyrimidin-2-yl)phenolate.

    PubMed

    Mitsuhashi, Ryoji; Suzuki, Takayoshi; Sunatsuki, Yukinari

    2013-09-01

    New ruthenium(II or III) complexes with general formula [Ru(O-N)(bpy)2](n+) (O-N = unsymmetrical bidentate phenolate ligand; bpy = 2,2'-bipyridine) were synthesized, and their crystal structures and electrochemical properties were characterized. Ru(II) complexes with 2-(2-imidazolinyl)phenolate (Himn(-)) or 2-(1,4,5,6-tetrahydropyrimidin-2-yl)phenolate (Hthp(-)) could be deprotonated by addition of excess KO(t)Bu, although the deprotonated species were easily reprotonated by exposure to air. Unlike these Ru(II) complexes, their Ru(III) analogs showed interesting ligand oxidation reactions upon addition of bases. With [Ru(III)(Himn)(bpy)2](2+), two-electron oxidation of Himn(-) and reduction of the Ru(III) center resulted in conversion of the 2-imidazolinyl group to a 2-imidazolyl group. On the other hand, the corresponding Hthp(-) complex exhibited four-electron oxidation of the ligand to form 2-(2-pyrimidyl)phenolate (pym(-)). These aromatization reactions of imidazolinyl and 1,4,5,6-tetrahydropyrimidyl groups were also achieved by the electrochemically generated Ru(III) complexes. PMID:23967872

  18. Proton/metal-ligand stability constants of complexes of Ni(II), Cu(II), and Co(II) with diethyl 4-(substituted-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in 70% dioxane-water mixture

    NASA Astrophysics Data System (ADS)

    Tekade, Pradip V.; Bajaj, Sonal D.; Thool, Seemita

    2015-12-01

    Physico-chemical properties viz proton-ligand and metal-ligand stability constants of complexes of diethyl 4-(substituted-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate with Ni(II), Cu(II), and Co(II) were determined in mixed solvents (70% dioxane). Presence of OH/NH group(s) in these compounds was confirmed at 0.1 M ionic strength in 70% dioxane-water mixture pH-metrically. It is observed that Ni(II), Cu(II), and Co(II) metal ions formed 1: 1 and 1: 2 complex with all the three ligands. The results show that the ratio of log K 1/log K 2 is positive in all cases. This implies that there is little or no steric hindrance to the addition of secondary molecules.

  19. STUDY OF A 10-MW CONTINUOUS SPALLATION NEUTRON SOURCE.

    SciTech Connect

    RUGGIERO,A.G.LUDEWIG,H.SHAPIRO,S.

    2003-05-12

    This paper reports on the feasibility study of a proton Super-Conducting Linac as the driver for an Accelerator-based Continuous Neutron Source (ACNS) [1] to be located at Brookhaven National Laboratory (BNL). The Linac is to be operated in the Continuous Wave (CW) mode to produce an average 10 MW of beam power. The Linac beam energy is taken to be 1.25 GeV. The required average proton beam intensity in exit is then 8 mA.

  20. Proton Therapy

    MedlinePlus

    ... nucleus is surrounded by electrons. In proton therapy, beams of fast-moving protons are used to destroy ... atoms to release proton, neutron, and helium ion beams. In this highly specialized form of radiosurgery , proton ...

  1. A conceptual design of the 2+ MW LBNE beam absorber

    SciTech Connect

    Velev, G.; Childress, S.; Hurh, P.; Hylen, J.; Makarov, A.; Mohkhov, N.; Moore, C.D.; Novitski, I.; /Fermilab

    2011-03-01

    The Long Baseline Neutrino Experiment (LBNE) will utilize a neutrino beamline facility located at Fermilab. The facility will aim a beam of neutrinos, produced by 60-120 GeV protons from the Fermilab Main Injector, toward a detector placed at the Deep Underground Science and Engineering Laboratory (DUSEL) in South Dakota. Secondary particles that do not decay into muons and neutrinos as well as any residual proton beam must be stopped at the end of the decay region to reduce noise/damage in the downstream muon monitors and reduce activation in the surrounding rock. This goal is achieved by placing an absorber structure at the end of the decay region. The requirements and conceptual design of such an absorber, capable of operating at 2+ MW primary proton beam power, is described.

  2. 20-MW Magnicon for ILC

    SciTech Connect

    Jay L. Hirshfield

    2006-11-29

    The 1.3 GHz RF power to drive ILC is now planned to be supplied by 600-1200, 10-MW peak power multi-beam klystrons. In this project, a conceptual design for 1.3 GHz magnicons with 20 MW peak power was developed as an alternative to the klystrons, with the possibility of cutting in half the numbers of high-power tubes and associated components. Design of a conventional magnicon is described, using TM110 modes in all cavities, as well as design of a modified magnicon with a TE111 mode output cavity. The latter has the advantage of much lower surface fields than the TM110 mode, with no loss of output power or electronic efficiency.

  3. 16 CFR 1.4 - Public disclosure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Public disclosure. 1.4 Section 1.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Advisory Opinions § 1.4 Public disclosure. Written advice rendered pursuant...

  4. 50 CFR 1.4 - Director.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 1 2014-10-01 2014-10-01 false Director. 1.4 Section 1.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.4 Director. Director means the Director, U.S. Fish and Wildlife Service or the...

  5. 50 CFR 1.4 - Director.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 1 2011-10-01 2011-10-01 false Director. 1.4 Section 1.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.4 Director. Director means the Director, U.S. Fish and Wildlife Service or the...

  6. 50 CFR 1.4 - Director.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 1 2012-10-01 2012-10-01 false Director. 1.4 Section 1.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.4 Director. Director means the Director, U.S. Fish and Wildlife Service or the...

  7. 50 CFR 1.4 - Director.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 1 2013-10-01 2013-10-01 false Director. 1.4 Section 1.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.4 Director. Director means the Director, U.S. Fish and Wildlife Service or the...

  8. 50 CFR 1.4 - Director.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Director. 1.4 Section 1.4 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS § 1.4 Director. Director means the Director, U.S. Fish and Wildlife Service or the...

  9. 45 CFR 1216.1-4 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Exceptions. 1216.1-4 Section 1216.1-4 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-4 Exceptions. (a) The requirements of § 1216.1-3 are...

  10. 16 CFR 1.4 - Public disclosure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Public disclosure. 1.4 Section 1.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Advisory Opinions § 1.4 Public disclosure. Written advice rendered pursuant...

  11. 45 CFR 1211.1-4 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Policy. 1211.1-4 Section 1211.1-4 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VOLUNTEER GRIEVANCE PROCEDURES § 1211.1-4 Policy. It is ACTION's policy to provide volunteers the widest latitude to present their grievances...

  12. 45 CFR 1216.1-4 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Exceptions. 1216.1-4 Section 1216.1-4 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONDISPLACEMENT OF EMPLOYED WORKERS AND NONIMPAIRMENT OF CONTRACTS FOR SERVICE § 1216.1-4 Exceptions. (a) The requirements of § 1216.1-3 are...

  13. 16 CFR 1.4 - Public disclosure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Public disclosure. 1.4 Section 1.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Advisory Opinions § 1.4 Public disclosure. Written advice rendered pursuant...

  14. 16 CFR 1.4 - Public disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Public disclosure. 1.4 Section 1.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Advisory Opinions § 1.4 Public disclosure. Written advice rendered pursuant...

  15. 16 CFR 1.4 - Public disclosure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Public disclosure. 1.4 Section 1.4 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE GENERAL PROCEDURES Industry Guidance Advisory Opinions § 1.4 Public disclosure. Written advice rendered pursuant...

  16. REPORT OF THE SNOWMASS M6 WORKING GROUP ON HIGH INTENSITY PROTON SOURCES.

    SciTech Connect

    CHOU,W.; WEI,J.

    2001-08-14

    The M6 working group had more than 40 active participants (listed in Section 4). During the three weeks at Snowmass, there were about 50 presentations, covering a wide range of topics associated with high intensity proton sources. The talks are listed in Section 5. This group also had joint sessions with a number of other working groups, including E1 (Neutrino Factories and Muon Colliders), E5 (Fixed-Target Experiments), M1 (Muon Based Systems), T4 (Particle Sources), T5 (Beam dynamics), T7 (High Performance Computing) and T9 (Diagnostics). The M6 group performed a survey of the beam parameters of existing and proposed high intensity proton sources, in particular, of the proton drivers. The results are listed in Table 1. These parameters are compared with the requirements of high-energy physics users of secondary beams in Working Groups E1 and E5. According to the consensus reached in the E1 and E5 groups, the U.S. HEP program requires an intense proton source, a 1-4 MW Proton Driver, by the end of this decade.

  17. Segmented beryllium target for a 2 MW super beam facility

    NASA Astrophysics Data System (ADS)

    Davenne, T.; Caretta, O.; Densham, C.; Fitton, M.; Loveridge, P.; Hurh, P.; Zwaska, R.; Hylen, J.; Papadimitriou, V.

    2015-09-01

    The Long Baseline Neutrino Facility (LBNF, formerly the Long Baseline Neutrino Experiment) is under design as a next generation neutrino oscillation experiment, with primary objectives to search for C P violation in the leptonic sector, to determine the neutrino mass hierarchy and to provide a precise measurement of θ23 . The facility will generate a neutrino beam at Fermilab by the interaction of a proton beam with a target material. At the ultimate anticipated proton beam power of 2.3 MW the target material must dissipate a heat load of between 10 and 25 kW depending on the target size. This paper presents a target concept based on an array of spheres and compares it to a cylindrical monolithic target such as that which currently operates at the T2K facility. Simulation results show that the proposed technology offers efficient cooling and lower stresses whilst delivering a neutrino production comparable with that of a conventional solid cylindrical target.

  18. UPGRADING THE SNS COMPRESSOR RING TO 3 MW.

    SciTech Connect

    WENG,W.T.; BLASKIEWICZ,M.; FEDOTOV,A.; LEE,Y.Y.; RAPARIA,D.; WEI,J.; DANILOV,V.; HENDERSON,S.; HOLMES,J.; HOLTKAMP,N.

    2002-06-03

    The initial performance goal for the SNS compressor ring is 1.4 MW with 1.0 GeV linac beam. During the design phase many considerations and provisions have been made to allow progressive increase in power level of the ring, ultimately to 3.0 MW and beyond after years of improvements. The most important provision for future higher power operation is an increase in beam energy from 1.0 to 1.3 GeV. Other possible upgrades covered in this report include ion source current, new stripper foil material, injection and extraction systems, transverse damper, barrier cavity, and electron clearing to avoid e-p instability.

  19. An upper limit for the proton lifetime in SO(10)

    NASA Astrophysics Data System (ADS)

    Buccella, F.; Miele, G.; Rosa, L.; Santorelli, P.; Tuzi, T.

    1989-12-01

    We find in a rather general class of SO(10) unified models the upper limit for the proton lifetime: τP⩽1.6×10 +33±3 yr, where the large error is due to the uncertainties on sin 2θw( MW) and α3( MW).

  20. 21 CFR 1.4 - Authority citations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Authority citations. 1.4 Section 1.4 Food and... REGULATIONS General Provisions § 1.4 Authority citations. (a) For each part of its regulations, the Food and... U.S. Statutes at Large. Citations to the U.S. Statutes at Large will refer to volume and page....

  1. Neutronic performance of a benchmark 1-MW LPSS

    SciTech Connect

    Russell, G.J.; Pitcher, E.J.; Ferguson, P.D.

    1995-12-31

    We used split-target/flux-trap-moderator geometry in our 1-MW LPSS computational benchmark performance calculations because the simulation models were readily available. Also, this target/moderator arrangement is a proven LANSCE design and a good neutronic performer. The model has four moderator viewed surfaces, each with a 13x13 cm field-of-view. For our scoping neutronic-performance calculations, we attempted to get as much engineering realism into the target-system mockup as possible. In our present model, we account for target/reflector dilution by cooling; the D{sub 2}O coolant fractions are adequate for 1 MW of 800-MeV protons (1.25 mA). We have incorporated a proton beam entry window and target canisters into the model, as well as (partial) moderator and vacuum canisters. The model does not account for target and moderator cooling lines and baffles, entire moderator canisters, and structural material in the reflector.

  2. Interconversion study in 1,4-substituted six-membered cyclohexane-type rings. Structure and dynamics of trans-1,4-dibromo-1,4-dicyanocyclohexane.

    PubMed

    Bain, Alex D; Baron, Maximo; Burger, Steven K; Kowalewski, Valdemar J; Rodríguez, Marina Belén

    2011-08-25

    Cyclohexane is an extremely flexible molecule that oscillates, at room temperature, between two clearly distinct and extreme conformations that cannot be distinguished at room temperature; so much so that the NMR spectrum is a single line that includes all 12 protons be they axial or equatorial. This raises the interesting question as to what happens when there are equal substituents at the 1 and 4 carbon atoms of the ring. Therefore substitution in the 1,4-positions in the cyclohexane ring has been the subject of considerable interest because some form of interconversion between extreme conformations could lead to the existence of a rather unusual behavior. To study this problem, the interconversion in (di- or tetra-1,4)-substituted six-membered cyclohexane-type rings, trans-1,4-dibromo-1,4-dicyanocyclohexane, was found to be a particularly suitable candidate. Although X-ray diffraction studies on the crystalline solid found the molecule to be centrosymmetric, it still shows a significant dipole moment μ in solution, as determined with a procedure that leads to the vapor phase values of μ. Furthermore, the low magnetic field proton NMR spectrum at ambient temperature appears as a single line, a situation that changes with increasing field intensity and different solvents. Both these effects are attributed to dynamics, because small distortions can easily disrupt the exact cancellation of the individual dipoles (which are quite strong) associated with each end of the molecule. The molecule can exist in two forms, with both the bromines in an axial geometry or both in an equatorial position. Interconversion between these forms is observed, as in the parent cyclohexane. The single NMR line observed at low magnetic fields is due to fast exchange and requires that the two forms have roughly equal populations. Spectra obtained at low temperature confirm this, and variable-temperature studies allow measurement of the rates, leading to an enthalpy of activation of 62 k

  3. Enantioselective Protonation

    PubMed Central

    Mohr, Justin T.; Hong, Allen Y.; Stoltz, Brian M.

    2010-01-01

    Enantioselective protonation is a common process in biosynthetic sequences. The decarboxylase and esterase enzymes that effect this valuable transformation are able to control both the steric environment around the proton acceptor (typically an enolate) and the proton donor (typically a thiol). Recently, several chemical methods to achieve enantioselective protonation have been developed by exploiting various means of enantiocontrol in different mechanisms. These laboratory transformations have proven useful for the preparation of a number of valuable organic compounds. PMID:20428461

  4. 21 CFR 1.4 - Authority citations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... listed: Sec. 701 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 371). (d) If the organic statute... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Authority citations. 1.4 Section 1.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL...

  5. 21 CFR 1.4 - Authority citations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... statute is the Federal Food, Drug, and Cosmetic Act, the Public Health Service Act, or the Fair Packaging...: Sec. 701 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 371). (d) If the organic statute is... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Authority citations. 1.4 Section 1.4 Food...

  6. 26 CFR 1.4-2 - Elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Elections. 1.4-2 Section 1.4-2 Internal Revenue....4-2 Elections. (a) Making of election. The election to pay the optional tax imposed under section 3... the standard deduction provided by section 141. (b) Election under section 3 and election of...

  7. 26 CFR 1.4-2 - Elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Elections. 1.4-2 Section 1.4-2 Internal Revenue....4-2 Elections. (a) Making of election. The election to pay the optional tax imposed under section 3... the standard deduction provided by section 141. (b) Election under section 3 and election of...

  8. 26 CFR 1.4-2 - Elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Elections. 1.4-2 Section 1.4-2 Internal Revenue....4-2 Elections. (a) Making of election. The election to pay the optional tax imposed under section 3... the standard deduction provided by section 141. (b) Election under section 3 and election of...

  9. 26 CFR 1.4-2 - Elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Elections. 1.4-2 Section 1.4-2 Internal Revenue....4-2 Elections. (a) Making of election. The election to pay the optional tax imposed under section 3... the standard deduction provided by section 141. (b) Election under section 3 and election of...

  10. 24 CFR 1.4 - Discrimination prohibited.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Discrimination prohibited. 1.4... DEVELOPMENT-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.4 Discrimination prohibited. (a... excluded from participation in, be denied the benefits of, or be otherwise subjected to...

  11. 24 CFR 1.4 - Discrimination prohibited.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Discrimination prohibited. 1.4... DEVELOPMENT-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.4 Discrimination prohibited. (a... excluded from participation in, be denied the benefits of, or be otherwise subjected to...

  12. 24 CFR 1.4 - Discrimination prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Discrimination prohibited. 1.4... DEVELOPMENT-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.4 Discrimination prohibited. (a... excluded from participation in, be denied the benefits of, or be otherwise subjected to...

  13. 24 CFR 1.4 - Discrimination prohibited.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discrimination prohibited. 1.4... DEVELOPMENT-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.4 Discrimination prohibited. (a... excluded from participation in, be denied the benefits of, or be otherwise subjected to...

  14. 24 CFR 1.4 - Discrimination prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Discrimination prohibited. 1.4... DEVELOPMENT-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 1.4 Discrimination prohibited. (a... excluded from participation in, be denied the benefits of, or be otherwise subjected to...

  15. 2 MW CW RF load for gyrotrons

    SciTech Connect

    Lawrence Ives, R.; Marsden, David; Mizuhara, Max; Collins, George; Neilson, Jeff; Borchard, Philipp

    2011-07-01

    Final design and assembly are in progress for a 2MW CW RF load for gyrotrons. Such loads are required for testing high power gyrotrons for electron cyclotron heating of fusion plasmas. The research is building on experience with a 1 MW load to increase the power capability, reduce backscattered RF power, and improve the mechanical design. (author)

  16. 1,4-Diazo­niabicyclo­[2.2.2]octane terephthalate

    PubMed Central

    Yang, E; Song, Xu-Chun; Zhu, Jian-Wei

    2008-01-01

    In the title compound, C6H14N2+·C8H4O4 2−, the protonated 1,4-diazo­niabicyclo­[2.2.2]octane cations and the deprotonated terephthalate anions are alternately linked by N—H⋯O hydrogen bonds into chains. PMID:21201746

  17. A Pion Production and Capture System for a 4 MW Target Station

    SciTech Connect

    Ding, X.; Kirk, H.; Berg, J.S.

    2010-06-01

    A study of a pion production and capture system for a 4 MW target station for a neutrino factory or muon collider is presented. Using the MARS code, we simulate the pion production produced by the interaction of a free liquid mercury jet with an intense proton beam. We study the variation of meson production with the direction of the proton beam relative to the target. We also examine the influence on the meson production by the focusing of the proton beam. The energy deposition in the capture system is determined and the shielding required in order to avoid radiation damage is discussed. The exploration for the multiple proton beam entry directions relative to mercury jet in the 8GeV proton beam case demonstrates that an asymmetric layout is required in order to achieve the same beam/jet crossing angle at the jet axis. We find a correlation between the distance of beam relative to the jet and the meson production. The peak meson production is 8% higher than for the lowest case. The examination of the influence on the meson production by the focusing of the proton beam shows the meson production loss is negligible (<1%) for a beta function to be 0.3m or higher for the proton beam. By investigating the energy deposition in the target/capture system, we see that the bulk of 4-MW proton beam power is deposited in the water cooled tungsten-carbide (WC) shielding, the mercury jet and the capture beam pipe. In addition, high power deposition in the first superconducting coil causes an issue for its operation and life time. Enhanced shielding is necessary to lower the radiation damage.

  18. 5 MW pulsed spallation neutron source, Preconceptual design study

    SciTech Connect

    Not Available

    1994-06-01

    This report describes a self-consistent base line design for a 5 MW Pulsed Spallation Neutron Source (PSNS). It is intended to establish feasibility of design and as a basis for further expanded and detailed studies. It may also serve as a basis for establishing project cost (30% accuracy) in order to intercompare competing designs for a PSNS not only on the basis of technical feasibility and technical merit but also on the basis of projected total cost. The accelerator design considered here is based on the objective of a pulsed neutron source obtained by means of a pulsed proton beam with average beam power of 5 MW, in {approx} 1 {mu}sec pulses, operating at a repetition rate of 60 Hz. Two target stations are incorporated in the basic facility: one for operation at 10 Hz for long-wavelength instruments, and one operating at 50 Hz for instruments utilizing thermal neutrons. The design approach for the proton accelerator is to use a low energy linear accelerator (at 0.6 GeV), operating at 60 Hz, in tandem with two fast cycling booster synchrotrons (at 3.6 GeV), operating at 30 Hz. It is assumed here that considerations of cost and overall system reliability may favor the present design approach over the alternative approach pursued elsewhere, whereby use is made of a high energy linear accelerator in conjunction with a dc accumulation ring. With the knowledge that this alternative design is under active development, it was deliberately decided to favor here the low energy linac-fast cycling booster approach. Clearly, the present design, as developed here, must be carried to the full conceptual design stage in order to facilitate a meaningful technology and cost comparison with alternative designs.

  19. Simulation of a regenerative MW FEL amplifier

    SciTech Connect

    Nguyen, R.T.; Colson, W.B.; Wong, R.K.; Sheffield, R.L.

    1997-08-01

    Both oscillator and regenerative amplifier configurations are being studied to optimize the design of a MW class FEL. The regenerative amplifier uses a longer undulator and relies on higher extraction efficiency to achieve high average power, whereas the oscillator is a more compact overall design requiring the transport of the high energy electron beam around bends for energy recovery. Using parameters extrapolated from the 1 kW LANL regenerative amplifier, simulations study the feasibility of achieving 1 MW average power.

  20. 49 CFR 1.4 - General responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... regulations, and administering air traffic control of civil and military air operations within U.S. airspace... citations affecting § 1.4, see the List of CFR Sections Affected, which appears in the Finding Aids section... the Federal Government; (4) Encouraging maximum private development of transportation services;...

  1. 49 CFR 1.4 - General responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... regulations, and administering air traffic control of civil and military air operations within U.S. airspace... citations affecting § 1.4, see the List of CFR Sections Affected, which appears in the Finding Aids section... the Federal Government; (4) Encouraging maximum private development of transportation services;...

  2. Proton Transport

    NASA Technical Reports Server (NTRS)

    Pohorille, Andrew; DeVincenzi, Donald L. (Technical Monitor)

    2001-01-01

    The transport of protons across membranes is an essential process for both bioenergetics of modern cells and the origins of cellular life. All living systems make use of proton gradients across cell walls to convert environmental energy into a high-energy chemical compound, adenosine triphosphate (ATP), synthesized from adenosine diphosphate. ATP, in turn, is used as a source of energy to drive many cellular reactions. The ubiquity of this process in biology suggests that even the earliest cellular systems were relying on proton gradient for harvesting environmental energy needed to support their survival and growth. In contemporary cells, proton transfer is assisted by large, complex proteins embedded in membranes. The issue addressed in this Study was: how the same process can be accomplished with the aid of similar but much simpler molecules that could have existed in the protobiological milieu? The model system used in the study contained a bilayer membrane made of phospholipid, dimyristoylphosphatidylcholine (DMPC) which is a good model of the biological membranes forming cellular boundaries. Both sides of the bilayer were surrounded by water which simulated the environment inside and outside the cell. Embedded in the membrane was a fragment of the Influenza-A M$_2$ protein and enough sodium counterions to maintain system neutrality. This protein has been shown to exhibit remarkably high rates of proton transport and, therefore, is an excellent model to study the formation of proton gradients across membranes. The Influenza M$_2$ protein is 97 amino acids in length, but a fragment 25 amino acids long. which contains a transmembrane domain of 19 amino acids flanked by three amino acids on each side. is sufficient to transport protons. Four identical protein fragments, each folded into a helix, aggregate to form small channels spanning the membrane. Protons are conducted through a narrow pore in the middle of the channel in response to applied voltage. This

  3. A 1- to 5-MW, RCS-based, short-pulse spallation neutron source

    SciTech Connect

    Cho, Y. Chae, Y.C.; Crosbie, E.

    1997-06-01

    Two accelerator configurations, the linac/compressor ring scheme and the linac/RCS scheme, are commonly used to provide the proton beam power for a short-pulse spallation neutron source. In one configuration, a full-power linac provides the beam power and a compressor ring shortens the pulse length from 1-ms down to 1 {micro}s. In the other, rapid cycling synchrotrons (RCSs) provide the beam power and also shorten the pulse length. A feasibility study of a staged approach to a 5-MW proton source utilizing RCS technology, allowing intermediate operation at 1 MW, was performed at ANL and is presented in this paper. This study is complementary to a study in progress at ORNL based on a linac and an accumulator ring. The 1-MW facility consists of a 400-MeV injector linac that delivers 0.5-mA time-averaged current, a synchrotron that accelerates the beam to 2 GeV at a 30-Hz rate, and two neutron-generating target stations. In the second phase, the 2-GeV beam is accelerated to 10 GeV by a larger RCS, increasing the facility beam power to 5 MW.

  4. Proton interrogation

    SciTech Connect

    Morris, Christopher L

    2008-01-01

    Energetic proton beams may provide an attractive alternative when compared to electromagnetic and neutron beams for active interrogation of nuclear threats because: they have large fission cross sections, long mean free paths and high penetration, and proton beams can be manipulated with magnetic optics. We have measured time-dependent cross sections for delayed neutrons and gamma-rays using the 800 MeV proton beam from the Los Alamos Neutron Science Center for a set of bare and shielded targets. The results show significant signals from both unshielded and shielded nuclear materials. Results will be presented.

  5. 7. Photocopy of photographca. 1927 (2 1/4 X 2 1/4' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Photocopy of photograph--ca. 1927 (2 1/4 X 2 1/4' negative) DETAIL SHOWING ADAPTATION THAT ALLOWED USE OF UPPER END OF ORIGINAL FLUME AND LOWER END JUST RECONSTRUCTED - Power Flume No. 1, Tacoma, La Plata County, CO

  6. Design of 250-MW CW RF system for APT

    SciTech Connect

    Rees, D.

    1997-09-01

    The design for the RF systems for the APT (Accelerator Production of Tritium) proton linac will be presented. The linac produces a continuous beam power of 130 MW at 1300 MeV with the installed capability to produce up to a 170 MW beam at 1700 MeV. The linac is comprised of a 350 MHz RFQ to 7 MeV followed in sequence by a 700 MHz coupled-cavity drift tube linac, coupled-cavity linac, and superconducting (SC) linac to 1700 MeV. At the 1700 MeV, 100 mA level the linac requires 213 MW of continuous-wave (CW) RF power. This power will be supplied by klystrons with a nominal output power of 1.0 MW. 237 kystrons are required with all but three of these klystrons operating at 700 MHz. The klystron count includes redundancy provisions that will be described which allow the RF systems to meet an operational availability in excess of 95 percent. The approach to achieve this redundancy will be presented for both the normal conducting (NC) and SC accelerators. Because of the large amount of CW RF power required for the APT linac, efficiency is very important to minimize operating cost. Operation and the RF system design, including in-progress advanced technology developments which improve efficiency, will be discussed. RF system performance will also be predicted. Because of the simultaneous pressures to increase RF system reliability, reduce tunnel envelope, and minimize RF system cost, the design of the RF vacuum windows has become an important issue. The power from a klystron will be divided into four equal parts to minimize the stress on the RF vacuum windows. Even with this reduction, the RF power level at the window is at the upper boundary of the power levels employed at other CW accelerator facilities. The design of a 350 MHz, coaxial vacuum window will be presented as well as test results and high power conditioning profiles. The transmission of 950 kW, CW, power through this window has been demonstrated with only minimal high power conditioning.

  7. COMPACT PROTON INJECTOR AND FIRST ACCELERATOR SYSTEM TEST FOR COMPACT PROTON DIELECTRIC WALL CANCER THERAPY ACCELERATOR

    SciTech Connect

    Chen, Y; Guethlein, G; Caporaso, G; Sampayan, S; Blackfield, D; Cook, E; Falabella, S; Harris, J; Hawkins, S; Nelson, S; Poole, B; Richardson, R; Watson, J; Weir, J; Pearson, D

    2009-04-23

    A compact proton accelerator for cancer treatment is being developed by using the high-gradient dielectric insulator wall (DWA) technology [1-4]. We are testing all the essential DWA components, including a compact proton source, on the First Article System Test (FAST). The configuration and progress on the injector and FAST will be presented.

  8. Demonstration of 5MW PAFC power plant

    SciTech Connect

    Usami, Yutaka; Takae, Toshio

    1996-12-31

    Phosphoric Acid Fuel Cell Technology Research Association, established in May 1991 by Japanese 10 electric power and 4 gas companies, started a new project in 1991 FY, with the object of PAFC realization and aiming the development of 5MW- class PAFC. power plant for urban energy center and 1 MW- class power plant for onsite use. This project is carried out as 6 years plan jointly with New Energy and Industrial Technology Development Organization. The targets of the project are to evaluate and resolve the development task, such as a high reliability, compactness and cost reduction throughout the engineering, manufacturing and field testing of PAFC power plants. PAC tests and power generating test operations of 5MW plant were completed in 1994. Conducting the 2 years continuous operations and studies since 1995, the plant operational performance, system control characteristics, waste heat recovery and environmental advantage will be demonstrated.

  9. SAS 3 observations of GX 1 + 4

    NASA Technical Reports Server (NTRS)

    Doty, J. P.; Lewin, W. H. G.; Hoffman, J. A.

    1981-01-01

    GX 1 + 4 is one of the brightest celestial sources of high-energy X-rays. It is a pulsar with a period of approximately 2 min (perhaps a multiple of 2 min), decreasing at a variable rate which, since 1971, has averaged approximately 2% per year, but which can be larger than 5% per year. This is the largest rate of decrease observed for any pulsar. The rate of decrease appears to be correlated with the luminosity, in support of the idea that the period decrease is produced by accretion torques acting upon a neutron star. No evidence is seen for a Doppler shift due to motion of the pulsar in a binary orbit; this is consistent with the results of optical observations which suggest that any orbital period is fairly long (months to years). The spectrum of GX 1 + 4 is measured as a function of pulse phase, as well as the phase-averaged total spectrum, and the average spectrum of the pulses alone. The shape of the average pulsed spectrum suggests that the pulsations may be produced by 'hot spots' which are a few hundred meters in extent, with temperatures of approximately 10 to the 8th K (kT being approximately equal to 8 keV).

  10. 1,4-Dihydro-1,4-diphosphinine fused with two tetrathiafulvalenes.

    PubMed

    Avarvari, Narcis; Fourmigué, Marc

    2004-12-21

    Electrochemical and theoretical investigations demonstrate through-bond interactions between two TTF moieties fused to a 1,4-dihydro-1,4-diphosphinine, for which the single crystal X-ray structure of the cis isomer is described together with that of a mixed-valent, charge-localized, radical cation salt with Mo6O19(2-), obtained upon electrocrystallization of the same cis isomer. PMID:15599410

  11. PCFB Repowering Project 80 MW plant description

    SciTech Connect

    Not Available

    1994-05-01

    This report documents the design of a 80 MW Pressurized Circulating Fluidized Bed (PCFB) boiler for the repowering of Unit 1 at the Des Moines Energy Center. Objective is to demonstrate that PCFB combined-cycle technology is cost effective and environmentally superior compared to traditional pulverized coal burning facilities.

  12. Quantum 1/4 BPS dyons

    NASA Astrophysics Data System (ADS)

    Bak, Dongsu; Lee, Kimyeong; Yi, Piljin

    2000-02-01

    Classical properties of 1/4 Bogomol'nyi-Prasad-Sommerfield (BPS) dyons were previously well understood both in the field theory context and in the string theory context. Its quantum properties, however, have been more difficult to probe, although the elementary information of the supermultiplet structures is known from a perturbative construction. Recently, a low energy effective theory of monopoles was constructed and argued to contain these dyons as quantum bound states. In this paper, we find these dyonic bound states explicitly in the N=4 supersymmetric low energy effective theory. After identifying the correct angular momentum operators, we motivate an anti-self-dual ansatz for all BPS bound states. The wave functions are found explicitly, whose spin contents and degeneracies match exactly the expected results.

  13. Proton therapy

    MedlinePlus

    ... skin redness in the radiation area, and temporary hair loss. AFTER THE PROCEDURE Following proton therapy, you should be able to resume your normal activities. You will likely see your doctor every 3 to 4 months for a follow-up exam.

  14. 5MW Raft River Facility Experience

    SciTech Connect

    Whitbeck, J.F.

    1980-12-01

    Located in Northern California In Lake and Sonoma Counties about 90 miles north of San Francisco, Pacific Gas and Electric Company's (PG and E's) The Geysers Power Plant, which has at present fourteen units in service with a net generating capacity of 798MW, is the largest geothermal development in the world. Eight additional PG and E units now in construction, design, and planning will add 720MW of additional capacity by 1986. Figure 1 shows the location of this project and the locations of the existing and future units. This paper discusses evolution of Geysers Unit 18 through resource and project planning, licensing, design, and what is expected during construction, and startup. While many of the experiences are unique to The Geysers units, some could be applicable to other geothermal developments. This unit is one of a series of 110MW units of standardized design which are being developed to reduce the cost and improve schedules. Construction has just commenced, and it is expected to be in commercial operation in October 1982.

  15. THERMAL SHOCK INDUCED BY A 24 GEV PROTON BEAM IN THE TEST WINDOWS OF THE MUON COLLIDER EXPERIMENT E951 - TEST RESULTS AND THEORETICAL PREDICTIONS.

    SciTech Connect

    SIMOS,N.; KIRK,H.; FINFROCK,C.; PRIGL,R.; BROWN,K.; KAHN,S.; LUDEWIG,H.; MCDONALDK.; CATES,M.; TSAI,J.; BESHEARS,D.; RIEMER,B.

    2001-11-11

    The need for intense muon beams for muon colliders and neutrino factories has lead to a concept of a high performance target station in which a 1-4 MW proton beam of 6-24 GeV impinges on a target inside a high field solenoid channel. While novel technical issues exist regarding the survivability of the target itself, the need to pass the tightly focused proton beam through beam windows poses additional concerns. In this paper, issues associated with the interaction of a proton beam with window structures designed for the muon targetry experiment E951 at BNL are explored. Specifically, a 24 GeV proton beam up to 16 x 10{sup 12} per pulse and a pulse length of approximately 100 ns is expected to be tightly focused (to 0.5 mm rms one sigma radius) on an experimental target. Such beam will induce very high thermal, quasi-static and shock stresses in the window structure that exceed the strength of most common materials. In this effort, a detailed assessment of the thermal/shock response of beam windows is attempted with a goal of identifying the best window material candidate. Further, experimental strain results and comparison with the predicted values are presented and discussed.

  16. INTERACTION OF A 24 GEV PROTON BEAM IWHT A MUON COLLIDER MERCURY JET TARGET EXPERIMENTAL RESULTS AND THERMODYNAMIC ASSESSMENT.

    SciTech Connect

    SIMOS,N.; KIRK,H.; FINFROCK,C.; GREENE,G.; LUDEWIG,H.; MCDONALD,K.; MOKHOV,N.

    2001-11-11

    A muon collider or a neutrino factory based on a muon storage ring require intense beams of muons that can be generated by a 1-4 MW proton beam incident on a moving target inside a 20-T solenoid magnet, with a mercury jet as a preferred example. This paper addresses the thermodynamic interaction of the intense proton beam with the proposed mercury jet target, and the consequences of the generated pressure waves on the target integrity. Specifically, a 24 GeV proton beam with approximately 16 TP (1 TP = 10{sup 12} protons) per pulse and a pulse length of 2 ns will interact with a 1 cm diameter mercury jet within the 20-Tesla magnetic field. In one option, a train of six such proton pulses is to be delivered on target within 2 {micro}s, in which case the state of the mercury jet following the interaction with each pulse is critical. Using the equation of state for mercury from the SESAME library, in combination with the energy deposition rates calculated the by the hadron interaction code MARS, the induced 3-D pressure field in the target is estimated. The consequent pressure wave propagation and attenuation in the mercury jet is calculated using a transient analysis based on finite element modeling, and the state of the mercury jet at the time of arrival of the subsequent pulse is assessed. Issues associated with the use of a liquid metal jet as a target candidate are addressed. Lastly, some experimental results from the BNL E951 experiment are presented and discussed.

  17. A 75 MW S-Band Klystron

    SciTech Connect

    Ferguson, Patrick; Read, Michael; Ives, Robert Lawrence; Marsden, David

    2013-12-16

    This program performed computational and preliminary mechanical design for a klystron producing 75 MW at 2.856 GHz using periodic permanent magnet (PPM) focusing. The performance specifications achieved were those for the Matter-Radiation Interactions in the Extremes (MaRIE) project at Los Alamos National Laboratory. The klystron is designed to provide 10 microsecond pulses at 60 Hz with 56 dB gain. The PPM-Focusing eliminates requirements for solenoids and their associated power supplies, cooling systems, interlocks, control and diagnostic instrumentation, and maintenance. The represents a significant in both acquisition and operating costs. It also increases reliability by eliminating many potential failure modes.

  18. MW-Class Electric Propulsion System Designs

    NASA Technical Reports Server (NTRS)

    LaPointe, Michael R.; Oleson, Steven; Pencil, Eric; Mercer, Carolyn; Distefano, Salvador

    2011-01-01

    Electric propulsion systems are well developed and have been in commercial use for several years. Ion and Hall thrusters have propelled robotic spacecraft to encounters with asteroids, the Moon, and minor planetary bodies within the solar system, while higher power systems are being considered to support even more demanding future space science and exploration missions. Such missions may include orbit raising and station-keeping for large platforms, robotic and human missions to near earth asteroids, cargo transport for sustained lunar or Mars exploration, and at very high-power, fast piloted missions to Mars and the outer planets. The Advanced In-Space Propulsion Project, High Efficiency Space Power Systems Project, and High Power Electric Propulsion Demonstration Project were established within the NASA Exploration Technology Development and Demonstration Program to develop and advance the fundamental technologies required for these long-range, future exploration missions. Under the auspices of the High Efficiency Space Power Systems Project, and supported by the Advanced In-Space Propulsion and High Power Electric Propulsion Projects, the COMPASS design team at the NASA Glenn Research Center performed multiple parametric design analyses to determine solar and nuclear electric power technology requirements for representative 300-kW class and pulsed and steady-state MW-class electric propulsion systems. This paper describes the results of the MW-class electric power and propulsion design analysis. Starting with the representative MW-class vehicle configurations, and using design reference missions bounded by launch dates, several power system technology improvements were introduced into the parametric COMPASS simulations to determine the potential system level benefits such technologies might provide. Those technologies providing quantitative system level benefits were then assessed for technical feasibility, cost, and time to develop. Key assumptions and primary

  19. Proton scaling

    SciTech Connect

    Canavan, Gregory H

    2009-01-01

    This note presents analytic estimates of the performance of proton beams in remote surveillance for nuclear materials. The analysis partitions the analysis into the eight steps used by a companion note: (1) Air scattering, (2) Neutron production in the ship and cargo, (3) Target detection probability, (4) Signal produced by target, (5) Attenuation of signal by ship and cargo, (6) Attenuation of signal by air, (7) Geometric dilution, and (8) Detector Efficiency. The above analyses indicate that the dominant air scattering and loss mechanisms for particle remote sensing are calculable with reliable and accepted tools. They make it clear that the conversion of proton beams into neutron sources rapidly goes to completion in all but thinnest targets, which means that proton interrogation is for all purposes executed by neutrons. Diffusion models and limiting approximations to them are simple and credible - apart from uncertainty over the cross sections to be used in them - and uncertainty over the structure of the vessels investigated. Multiplication is essentially unknown, in part because it depends on the details of the target and its shielding, which are unlikely to be known in advance. Attenuation of neutron fluxes on the way out are more complicated due to geometry, the spectrum of fission neutrons, and the details of their slowing down during egress. The attenuation by air is large but less uncertain. Detectors and technology are better known. The overall convolution of these effects lead to large but arguably tolerable levels of attenuation of input beams and output signals. That is particularly the case for small, mobile sensors, which can more than compensate for size with proximity to operate reliably while remaining below flux limits. Overall, the estimates used here appear to be of adequate accuracy for decisions. That assessment is strengthened by their agreement with companion calculations.

  20. High-Intensity Proton Accelerator

    SciTech Connect

    Jay L. Hirshfield

    2011-12-27

    Analysis is presented for an eight-cavity proton cyclotron accelerator that could have advantages as compared with other accelerators because of its potentially high acceleration gradient. The high gradient is possible since protons orbit in a sequence of TE111 rotating mode cavities of equally diminishing frequencies with path lengths during acceleration that greatly exceed the cavity lengths. As the cavities operate at sequential harmonics of a basic repetition frequency, phase synchronism can be maintained over a relatively wide injection phase window without undue beam emittance growth. It is shown that use of radial vanes can allow cavity designs with significantly smaller radii, as compared with simple cylindrical cavities. Preliminary beam transport studies show that acceptable extraction and focusing of a proton beam after cyclic motion in this accelerator should be possible. Progress is also reported on design and tests of a four-cavity electron counterpart accelerator for experiments to study effects on beam quality arising from variations injection phase window width. This device is powered by four 500-MW pulsed amplifiers at 1500, 1800, 2100, and 2400 MHz that provide phase synchronous outputs, since they are driven from a with harmonics derived from a phase-locked 300 MHz source.

  1. A Superconducting Linac Proton Driver at Fermilab

    NASA Astrophysics Data System (ADS)

    Foster, G. William

    2004-05-01

    A proton driver has emerged as the leading candidate for Fermilab's next near-term accelerator project. The preferred technical solution is an 8 GeV superconducting linac based on technology developed for TESLA and the Spallation Neutron Source (SNS). Its primary mission is to serve as a single-stage H- injector to prepare 2 MW "Super-Beams" for Neutrino experiments using the Fermilab Main Injector. The linac can also accelerate electrons, protons, and relativistic muons, permitting future applications such as a driver for an FEL, a long-pulse spallation source, the driver for an intense 8 GeV neutrino or kaon program, and potential applications to a neutrino factory or muon collider. The technical design of the 8 GeV linac, as well as the design of an alternative synchrotron based proton driver, will be described along with plans for project proposal and construction.

  2. 3 MW Solid Rotating Target Design

    SciTech Connect

    McManamy, Thomas J; Gallmeier, Franz X; Rennich, Mark J; Ferguson, Phillip D; Janney, Jim G

    2010-01-01

    A rotating solid target design concept is being developed for potential use at the second SNS target station (STS). A long pulse beam (~ 1 msec) at 1.3 GeV and 20 Hz is planned with power levels at or above 1 MW. Since the long pulse may give future opportunities for higher power, this study is looking at 3 MW to compare the performance of a solid rotating target to a mercury target. Unlike the case for stationary solid targets at such powers this study indicates that a rotating solid target, when used with large coupled hydrogen moderators, has neutronic performance equal to or better than that with a mercury target, and the solid target has a greatly increased lifetime. Design studies have investigated water cooled tungsten targets with tantalum cladding approximately 1.2 m in diameter, and 70mm thick. Operating temperatures are low ( < 150 C) with mid-plane, top and bottom surface cooling. In case of cooling system failure, the diameter gives enough surface area to remove the decay heat by radiation to the surrounding reflector assemblies while keeping the peak temperatures below approximately 700 C. This temperature should mitigate potential loss of coolant accidents and subsequent steam, tungsten interaction which has a threshold of approximately 800 C. Design layouts for the sealing systems and potential target station concepts have been developed.

  3. Development of multi-purpose MW gyrotrons for fusion devices

    NASA Astrophysics Data System (ADS)

    Minami, R.; Kariya, T.; Imai, T.; Numakura, T.; Endo, Y.; Nakabayashi, H.; Eguchi, T.; Shimozuma, T.; Kubo, S.; Yoshimura, Y.; Igami, H.; Takahashi, H.; Mutoh, T.; Ito, S.; Idei, H.; Zushi, H.; Yamaguchi, Y.; Sakamoto, K.; Mitsunaka, Y.; the GAMMA 10 Group

    2013-06-01

    The latest development achievements in the University of Tsukuba of over-1 MW power level gyrotrons required in present-day fusion devices, GAMMA 10, Large Helical Device (LHD), QUEST, Heliotron J and NSTX, are presented. The obtained maximum outputs are 1.9 MW for 0.1 s on the 77 GHz LHD tube and 1.2 MW for 1 ms on the 28 GHz GAMMA 10 one, which are new records in these frequency ranges. In long-pulse operation, 0.3 MW for 40 min at 77 GHz and 0.54 MW for 2 s at 28 GHz are achieved. A new programme of 154 GHz 1 MW development has started for high-density plasma heating in LHD. On the first 154 GHz tube, 1.0 MW for 1 s is achieved. As a next activity of the 28 GHz gyrotron, an over-1.5 MW gyrotron is designed and fabricated to study the multi-MW oscillation. The possibility of 0.4 MW continuous wave and 2 MW level output in operations of a few seconds, after the improvements of output window and mode converter, is shown. Moreover, a new design study of dual-frequency gyrotron at 28 and 35 GHz has started, which indicates the practicability of the multi-purpose gyrotron.

  4. 43 CFR 3191.1-4 - Public hearing on petition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Public hearing on petition. 3191.1-4 Section 3191.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... AGREEMENTS AND CONTRACTS FOR OIL AND GAS INSPECTION Delegation of Authority § 3191.1-4 Public hearing...

  5. 5 CFR 1.4 - Extent of the excepted service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Extent of the excepted service. 1.4 Section 1.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.4 Extent of the excepted service. (a) The excepted service shall include all...

  6. 7 CFR 1.4 - Public access to certain materials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Public access to certain materials. 1.4 Section 1.4 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.4 Public access to certain materials. (a) In accordance with 5 U.S.C. 552(a)(2), each agency within the...

  7. 7 CFR 1.4 - Public access to certain materials.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Public access to certain materials. 1.4 Section 1.4 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.4 Public access to certain materials. (a) In accordance with 5 U.S.C. 552(a)(2), each agency within the...

  8. IRIS Toxicological Review of 1,4-Dioxane (2010 Final)

    EPA Science Inventory

    The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, ...

  9. 47 CFR 1.4 - Computation of time.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Computation of time. 1.4 Section 1.4 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE General Rules of Practice and Procedure General § 1.4 Computation of time. (a) Purpose. The purpose of this rule section is to detail the method for computing the amount of...

  10. 5 CFR 1.4 - Extent of the excepted service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Extent of the excepted service. 1.4 Section 1.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES COVERAGE AND DEFINITIONS (RULE I) § 1.4 Extent of the excepted service. (a) The excepted service shall include all...

  11. 26 CFR 1.4-1 - Number of exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Number of exemptions. 1.4-1 Section 1.4-1... and Surtaxes § 1.4-1 Number of exemptions. (a) For the purpose of determining the optional tax imposed under section 3, the taxpayer shall use the number of exemptions allowable to him as deductions...

  12. 26 CFR 1.4-1 - Number of exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Number of exemptions. 1.4-1 Section 1.4-1... and Surtaxes § 1.4-1 Number of exemptions. (a) For the purpose of determining the optional tax imposed under section 3, the taxpayer shall use the number of exemptions allowable to him as deductions...

  13. 100 MW klystron development at SLAC

    SciTech Connect

    Vlieks, A.E.; Callin, R.S.; Caryotakis, G.; Fant, K.S.; Fowkes, W.R.; Lee, T.G.; Wright, E.L.

    1991-05-01

    A klystron designed to operate at 11.4 GHz and 440 kV is presently SLAC's strongest rf power source candidate for the Next Linear Collider. It is expected to provide 100 MW of rf power with a pulse width of 1 microsecond. Many of the conventional tube technologies are being pushed to their limits. High electron beam power densities, rf electric gradients in cavity gaps and stresses on the ceramic rf output windows are among the most severe problems to be dealt with. This paper describes progress in the development of this device including results from single and double gap output cavities and various styles of rf output windows. 6 refs., 3 figs., 1 tab.

  14. Proton-Proton Elastic Scattering Excitation Functions at Intermediate Energies

    SciTech Connect

    Bisplinghoff, J.; Daniel, R.; Diehl, O.; Engelhardt, H.; Ernst, J.; Eversheim, P.; Gro-Hardt, R.; Heider, S.; Heine, A.; Hinterberger, F.; Jahn, R.; Jeske, M.; Lahr, U.; Maschuw, R.; Mayer-Kuckuk, T.; Mosel, F.; Rohdje, H.; Rosendaal, D.; Ro, U.; Scheid, H.; Schulz-Rojahn, M.; Schwandt, F.; Schwarz, V.; Trelle, H.; Wiedmann, W.; Ziegler, R.; Albers, D.; Bollmann, R.; Bueer, K.; Dohrmann, F.; Gasthuber, M.; Greiff, J.; Gro, A.; Igelbrink, M.; Langkau, R.; Lindlein, J.; Mueller, M.; Muenstermann, M.; Schirm, N.; Scobel, W.; Wellinghausen, A.; Woller, K.; Cloth, P.; Gebel, R.; Maier, R.; Prasuhn, D.; von Rossen, P.; Sterzenbach, G.

    1997-03-01

    Excitation functions of proton-proton elastic scattering cross sections have been measured in narrow steps for projectile momenta p{sub p} (energies T{sub p}) from 1100 to 3300MeV/c (500 to 2500MeV) in the angular range 35{degree}{le}{Theta}{sub c.m.}{le}90{degree} with a detector providing {Delta}{Theta}{sub c.m.}{approx}1.4{degree} resolution. Measurements have been performed continuously during projectile acceleration in the cooler synchrotron COSY with an internal CH{sub 2} fiber target, taking particular care to monitor luminosity as a function of T{sub p}. The advantages of this experimental technique are demonstrated, and the excitation functions obtained are compared to existing cross section data. No evidence for narrow structures was found. {copyright} {ital 1997} {ital The American Physical Society}

  15. 40 CFR 721.990 - 1,4-Benzedicarboxylic acid, dimethyl ester, polymer with 1,4 - butanediol, cyclized.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ester, polymer with 1,4 - butanediol, cyclized. 721.990 Section 721.990 Protection of Environment..., dimethyl ester, polymer with 1,4 - butanediol, cyclized. (a) Chemical substance and significant new uses..., polymer with 1,4 - butanediol, cyclized (PMN P-00-0789; CAS No. 263244-54-8) is subject to reporting...

  16. 40 CFR 721.990 - 1,4-Benzedicarboxylic acid, dimethyl ester, polymer with 1,4 - butanediol, cyclized.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ester, polymer with 1,4 - butanediol, cyclized. 721.990 Section 721.990 Protection of Environment..., dimethyl ester, polymer with 1,4 - butanediol, cyclized. (a) Chemical substance and significant new uses..., polymer with 1,4 - butanediol, cyclized (PMN P-00-0789; CAS No. 263244-54-8) is subject to reporting...

  17. 40 CFR 721.990 - 1,4-Benzedicarboxylic acid, dimethyl ester, polymer with 1,4 - butanediol, cyclized.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ester, polymer with 1,4 - butanediol, cyclized. 721.990 Section 721.990 Protection of Environment..., dimethyl ester, polymer with 1,4 - butanediol, cyclized. (a) Chemical substance and significant new uses..., polymer with 1,4 - butanediol, cyclized (PMN P-00-0789; CAS No. 263244-54-8) is subject to reporting...

  18. 40 CFR 721.990 - 1,4-Benzedicarboxylic acid, dimethyl ester, polymer with 1,4 - butanediol, cyclized.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ester, polymer with 1,4 - butanediol, cyclized. 721.990 Section 721.990 Protection of Environment..., dimethyl ester, polymer with 1,4 - butanediol, cyclized. (a) Chemical substance and significant new uses..., polymer with 1,4 - butanediol, cyclized (PMN P-00-0789; CAS No. 263244-54-8) is subject to reporting...

  19. 40 CFR 721.990 - 1,4-Benzedicarboxylic acid, dimethyl ester, polymer with 1,4 - butanediol, cyclized.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ester, polymer with 1,4 - butanediol, cyclized. 721.990 Section 721.990 Protection of Environment..., dimethyl ester, polymer with 1,4 - butanediol, cyclized. (a) Chemical substance and significant new uses..., polymer with 1,4 - butanediol, cyclized (PMN P-00-0789; CAS No. 263244-54-8) is subject to reporting...

  20. Proton radiography to improve proton therapy treatment

    NASA Astrophysics Data System (ADS)

    Takatsu, J.; van der Graaf, E. R.; Van Goethem, M.-J.; van Beuzekom, M.; Klaver, T.; Visser, J.; Brandenburg, S.; Biegun, A. K.

    2016-01-01

    The quality of cancer treatment with protons critically depends on an accurate prediction of the proton stopping powers for the tissues traversed by the protons. Today, treatment planning in proton radiotherapy is based on stopping power calculations from densities of X-ray Computed Tomography (CT) images. This causes systematic uncertainties in the calculated proton range in a patient of typically 3-4%, but can become even 10% in bone regions [1,2,3,4,5,6,7,8]. This may lead to no dose in parts of the tumor and too high dose in healthy tissues [1]. A direct measurement of proton stopping powers with high-energy protons will allow reducing these uncertainties and will improve the quality of the treatment. Several studies have shown that a sufficiently accurate radiograph can be obtained by tracking individual protons traversing a phantom (patient) [4,6,10]. Our studies benefit from the gas-filled time projection chambers based on GridPix technology [2], developed at Nikhef, capable of tracking a single proton. A BaF2 crystal measuring the residual energy of protons was used. Proton radiographs of phantom consisting of different tissue-like materials were measured with a 30×30 mm2 150 MeV proton beam. Measurements were simulated with the Geant4 toolkit.First experimental and simulated energy radiographs are in very good agreement [3]. In this paper we focus on simulation studies of the proton scattering angle as it affects the position resolution of the proton energy loss radiograph. By selecting protons with a small scattering angle, the image quality can be improved significantly.

  1. Science to Practice: Highly Shifted Proton MR imaging—A Shift toward Better Cell Tracking?

    PubMed Central

    Bulte, Jeff W. M.

    2015-01-01

    Summary A “hot spot” magnetic resonance (MR) imaging cell tracking technique has been developed that allows direct detection of dysprosium- or thulium-1,4,7,10-tetraazacyclododecane-α,α′,α″,α‴-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA)–labeled protons inside cells. These highly shifted protons may allow specific detection of multiple cell types because it does not rely on acquiring the proton signal from bulk water. PMID:25153271

  2. Aerodynamic and Structural Design of MultiMW Wind Turbine Blades beyond 5MW

    NASA Astrophysics Data System (ADS)

    Hillmer, B.; Borstelmann, T.; Schaffarczyk, P. A.; Dannenberg, L.

    2007-07-01

    A unified approach was taken to the design of wind-turbine blades for multiMW machines up to 10 MW. Using input from standard existing machines, three baseline versions were designed. Then - after up-scaling - using the aero-elastic code FLEX5 a typical extreme load case was selected. As a result, weights seem to increase more than might be expected by an empirical law deduced from statistical data. However, some further investigations are needed, e. g. buckling and fatigue analyses. The authors regard the method developed here as a useful approach for pre-design investigation. One important aspect seems to be the need for high-quality GRPs, with admissible strength of more than 120 MPa.

  3. Radiation protection studies for a high-power 160 MeV proton linac

    NASA Astrophysics Data System (ADS)

    Mauro, Egidio; Silari, Marco

    2009-07-01

    CERN is presently designing a new chain of accelerators to replace the present Proton Synchrotron (PS) complex: a 160 MeV room-temperature H - linac (Linac4) to replace the present 50 MeV proton linac injector, a 3.5 GeV Superconducting Proton Linac (SPL) to replace the 1.4 GeV PS Booster (PSB) and a 50 GeV synchrotron (named PS2) to replace the 26 GeV PS. Linac4 has been funded and the civil engineering work started in October 2008, whilst the SPL is in an advanced stage of design. Beyond injecting into the future 50 GeV PS, the ultimate goal of the SPL is to generate a 4 MW beam for the production of intense neutrino beams. The radiation protection design is driven by the latter requirement. This work summarizes the radiation protection studies conducted for Linac4. FLUKA Monte Carlo simulations, complemented by analytical estimates, were performed to evaluate the propagation of neutrons through the waveguide, ventilation and cable ducts placed along the accelerator, to estimate the radiological impact of the accelerator in its low-energy section, where the access area is located, and to calculate the induced radioactivity in the air and in the components of the accelerator. The latter study is particularly important for maintenance interventions and final disposal of radioactive waste. Two possible layouts for the CCDTL section of the machine were considered in order to evaluate the feasibility, from the radiological standpoint, of replacing electromagnetic quadrupoles with permanent magnet quadrupoles with a high content of cobalt.

  4. Development of a 5 MW reference gearbox for offshore wind turbines: 5 MW reference gearbox

    SciTech Connect

    Nejad, Amir Rasekhi; Guo, Yi; Gao, Zhen; Moan, Torgeir

    2015-07-27

    This paper presents detailed descriptions, modeling parameters and technical data of a 5MW high-speed gearbox developed for the National Renewable Energy Laboratory offshore 5MW baseline wind turbine. The main aim of this paper is to support the concept studies and research for large offshore wind turbines by providing a baseline gearbox model with detailed modeling parameters. This baseline gearbox follows the most conventional design types of those used in wind turbines. It is based on the four-point supports: two main bearings and two torque arms. The gearbox consists of three stages: two planetary and one parallel stage gears. The gear ratios among the stages are calculated in a way to obtain the minimum gearbox weight. The gearbox components are designed and selected based on the offshore wind turbine design codes and validated by comparison to the data available from large offshore wind turbine prototypes. All parameters required to establish the dynamic model of the gearbox are then provided. Moreover, a maintenance map indicating components with high to low probability of failure is shown. The 5 MW reference gearbox can be used as a baseline for research on wind turbine gearboxes and comparison studies. It can also be employed in global analysis tools to represent a more realistic model of a gearbox in a coupled analysis.

  5. Proton decay theory

    SciTech Connect

    Marciano, W.J.

    1983-01-01

    Topics include minimal SU(5) predictions, gauge boson mediated proton decay, uncertainties in tau/sub p/, Higgs scalar effects, proton decay via Higgs scalars, supersymmetric SU(5), dimension 5 operators and proton decay, and Higgs scalars and proton decay. (WHK)

  6. Heteronuclear proton assisted recoupling

    NASA Astrophysics Data System (ADS)

    De Paëpe, Gaël; Lewandowski, Józef R.; Loquet, Antoine; Eddy, Matt; Megy, Simon; Böckmann, Anja; Griffin, Robert G.

    2011-03-01

    We describe a theoretical framework for understanding the heteronuclear version of the third spin assisted recoupling polarization transfer mechanism and demonstrate its potential for detecting long-distance intramolecular and intermolecular 15N-13C contacts in biomolecular systems. The pulse sequence, proton assisted insensitive nuclei cross polarization (PAIN-CP) relies on a cross term between 1H-15N and 1H-13C dipolar couplings to mediate zero- and/or double-quantum 15N-13C recoupling. In particular, using average Hamiltonian theory we derive effective Hamiltonians for PAIN-CP and show that the transfer is mediated by trilinear terms of the form N±C∓Hz (ZQ) or N±C±Hz (DQ) depending on the rf field strengths employed. We use analytical and numerical simulations to explain the structure of the PAIN-CP optimization maps and to delineate the appropriate matching conditions. We also detail the dependence of the PAIN-CP polarization transfer with respect to local molecular geometry and explain the observed reduction in dipolar truncation. In addition, we demonstrate the utility of PAIN-CP in structural studies with 15N-13C spectra of two uniformly 13C,15N labeled model microcrystalline proteins—GB1, a 56 amino acid peptide, and Crh, a 85 amino acid domain swapped dimer (MW = 2 × 10.4 kDa). The spectra acquired at high magic angle spinning frequencies (ωr/2π > 20 kHz) and magnetic fields (ω0H/2π = 700-900 MHz) using moderate rf fields, yield multiple long-distance intramonomer and intermonomer 15N-13C contacts. We use these distance restraints, in combination with the available x-ray structure as a homology model, to perform a calculation of the monomer subunit of the Crh protein.

  7. Synchrotron based proton drivers

    SciTech Connect

    Weiren Chou

    2002-09-19

    Proton drivers are the proton sources that produce intense short proton bunches. They have a wide range of applications. This paper discusses the proton drivers based on high-intensity proton synchrotrons. It gives a review of the high-intensity proton sources over the world and a brief report on recent developments in this field in the U.S. high-energy physics (HEP) community. The Fermilab Proton Driver is used as a case study for a number of challenging technical design issues.

  8. 49 CFR 172.523 - EXPLOSIVES 1.4 placard.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false EXPLOSIVES 1.4 placard. 172.523 Section 172.523... SECURITY PLANS Placarding § 172.523 EXPLOSIVES 1.4 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on the EXPLOSIVES 1.4 placard must be orange. The “*” shall be...

  9. 49 CFR 172.523 - EXPLOSIVES 1.4 placard.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false EXPLOSIVES 1.4 placard. 172.523 Section 172.523... SECURITY PLANS Placarding § 172.523 EXPLOSIVES 1.4 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on the EXPLOSIVES 1.4 placard must be orange. The “*” shall be...

  10. 49 CFR 172.523 - EXPLOSIVES 1.4 placard.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false EXPLOSIVES 1.4 placard. 172.523 Section 172.523... SECURITY PLANS Placarding § 172.523 EXPLOSIVES 1.4 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on the EXPLOSIVES 1.4 placard must be orange. The “*” shall be...

  11. 49 CFR 172.523 - EXPLOSIVES 1.4 placard.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false EXPLOSIVES 1.4 placard. 172.523 Section 172.523... SECURITY PLANS Placarding § 172.523 EXPLOSIVES 1.4 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on the EXPLOSIVES 1.4 placard must be orange. The “*” shall be...

  12. 49 CFR 172.523 - EXPLOSIVES 1.4 placard.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false EXPLOSIVES 1.4 placard. 172.523 Section 172.523... SECURITY PLANS Placarding § 172.523 EXPLOSIVES 1.4 placard. (a) Except for size and color, the EXPLOSIVES 1... subpart, the background color on the EXPLOSIVES 1.4 placard must be orange. The “*” shall be...

  13. 7 CFR 1.4 - Public access to certain materials.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Public access to certain materials. 1.4 Section 1.4 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.4 Public access to certain materials. (a) In accordance with 5 U.S.C. 552(a)(2), each agency within the Department shall make the following...

  14. 250-MHz synchronously pumped optical parametric oscillator at 2.25-2.6 μm and 4.1-4.9 μm.

    PubMed

    Coluccelli, Nicola; Fonnum, Helge; Haakestad, Magnus; Gambetta, Alessio; Gatti, Davide; Marangoni, Marco; Laporta, Paolo; Galzerano, Gianluca

    2012-09-24

    A compact and versatile femtosecond mid-IR source is presented, based on an optical parametric oscillator (OPO) synchronously pumped by a commercial 250-MHz Er:fiber laser. The mid-IR spectrum can be tuned in the range 2.25-2.6 μm (signal) and 4.1-4.9 μm (idler), with average power from 20 to 60 mW. At 2.5 μm a minimum pulse duration of 110 fs and a power of 40 mW have been obtained. Active stabilization of the OPO cavity length has been achieved in the whole tuning range. PMID:23037354

  15. Proton Therapy - Accelerating Protons to Save Lives

    SciTech Connect

    Keppel, Cynthia

    2011-10-25

    In 1946, physicist Robert Wilson first suggested that protons could be used as a form of radiation therapy in the treatment of cancer because of the sharp drop-off that occurs on the distal edge of the radiation dose. Research soon confirmed that high-energy protons were particularly suitable for treating tumors near critical structures, such as the heart and spinal column. The precision with which protons can be delivered means that more radiation can be deposited into the tumor while the surrounding healthy tissue receives substantially less or, in some cases, no radiation. Since these times, particle accelerators have continuously been used in cancer therapy and today new facilities specifically designed for proton therapy are being built in many countries. Proton therapy has been hailed as a revolutionary cancer treatment, with higher cure rates and fewer side effects than traditional X-ray photon radiation therapy. Proton therapy is the modality of choice for treating certain small tumors of the eye, head or neck. Because it exposes less of the tissue surrounding a tumor to the dosage, proton therapy lowers the risk of secondary cancers later in life - especially important for young children. To date, over 80,000 patients worldwide have been treated with protons. Currently, there are nine proton radiation therapy facilities operating in the United States, one at the Hampton University Proton Therapy Institute. An overview of the treatment technology and this new center will be presented.

  16. The DIII-D 3 MW, 110 GHz ECH System

    SciTech Connect

    Callis, R.W.; Lohr, J.; Ponce, D.; O'Neill, R.C.; Prater, R.; Luce, T.C.

    1999-07-01

    Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2s at 0.5 MW and 10s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HEl 1 mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW.

  17. Automated Solution-Phase Synthesis of β-1,4-Mannuronate and β-1,4-Mannan

    PubMed Central

    2016-01-01

    The first automated solution-phase synthesis of β-1,4-mannuronate and β-1,4-mannan oligomers has been accomplished by using a β-directing C-5 carboxylate strategy. By utilizing fluorous-tag assisting purification after repeated reaction cycles, β-1,4-mannuronate was synthesized up to a hexasaccharide with limited loading of a glycosyl donor (up to 3.5 equiv) for each glycosylation cycle due to the homogeneous solution-phase reaction condition. After a global reduction of the uronates, the β-1,4-mannan hexasaccharide was obtained, thereby demonstrating a new approach to β-mannan synthesis. PMID:25955886

  18. Automated Solution-Phase Synthesis of β-1,4-Mannuronate and β-1,4-Mannan.

    PubMed

    Tang, Shu-Lun; Pohl, Nicola L B

    2015-06-01

    The first automated solution-phase synthesis of β-1,4-mannuronate and β-1,4-mannan oligomers has been accomplished by using a β-directing C-5 carboxylate strategy. By utilizing fluorous-tag assisting purification after repeated reaction cycles, β-1,4-mannuronate was synthesized up to a hexasaccharide with limited loading of a glycosyl donor (up to 3.5 equiv) for each glycosylation cycle due to the homogeneous solution-phase reaction condition. After a global reduction of the uronates, the β-1,4-mannan hexasaccharide was obtained, thereby demonstrating a new approach to β-mannan synthesis. PMID:25955886

  19. Thermodynamic behaviour of bistable NH +-N hydrogen bonds in monosalts of 1,4-diazabicyclo[2.2.2]octane

    NASA Astrophysics Data System (ADS)

    Szafrański, Marek; Katrusiak, Andrzej

    2000-02-01

    Proton dynamics in NH +-N hydrogen bonds is characterized by high-pressure dielectric and calorimetric studies of ferroelectric/paraelectric phase transitions in perchlorate and tetrafluoroborate mono-salts of 1,4-diazabicyclo[2.2.2]octane (DABCO), [C 6H 13N 2] +·ClO 4- and [C 6H 13N 2] +·BF 4-. The p- T phase diagrams of these ferroelectrics have been determined and described. The positive pressure dependences of Tc testify to the strong coupling of the ionic dynamics with the proton disordering in the NH +-N hydrogen bonds. Close isostructurality of the crystals provides a unique opportunity for analysing the proton disordering at varied crystal environments.

  20. 27 CFR 1.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., Delegation of the Administrator's Authorities in 27 CFR Part 1, Basic Permit Requirements Under the Federal... Administrator. 1.4 Section 1.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Delegations of the Administrator. Most of the regulatory authorities of the Administrator contained in...

  1. Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution

    PubMed Central

    Ferreira de Carvalho Patricio, Beatriz; Lima-Ribeiro, Maria Helena Madruga; dos Santos Correia, Maria Tereza; dos Anjos Carneiro-Leão, Ana Maria; de Souza Albernaz, Marta; Barboza, Thiago; de Souza, Sergio Augusto Lopes; Santos-Oliveira, Ralph

    2011-01-01

    The cramoll 1,4 is a well-studied lectin. However, few studies about its biodistribution have been done before. In this study, we radiolabeled the cramol 1,4 with Tc-99m and analyzed the biodistribution. The results showed that the cramol has an abnormal uptake by the bowel with reflections on its clearance mechanism. PMID:21760823

  2. A Modular Synthetic Approach to Monocyclic 1,4-Azaborines.

    PubMed

    Liu, Xuguang; Zhang, Yuanzhe; Li, Bo; Zakharov, Lev N; Vasiliu, Monica; Dixon, David A; Liu, Shih-Yuan

    2016-07-11

    A simple and general method for the synthesis of a wide range of monocyclic 1,4-azaborines, including the first examples containing B heteroatoms is described. Post-heterocycle-formation olefin isomerization was employed as a key strategy. This new synthetic method provides fundamental insight into the resonance stabilization and photophysical properties of 1,4-azaborines. PMID:27238094

  3. Photochemistry Of 2,5-Diacyl-1, 4-Dimethylbenzenes

    NASA Technical Reports Server (NTRS)

    Meador, Michael A.

    1989-01-01

    Experiments described in report revealed potentially useful aspects of photochemistry of 2,5-dibenzoyl-1, 4-dimethylbenzene (DBX) and 2,5-diacetyl-1, 4-dimethylbenzene (DAX). Behavior of these compounds reminiscent of orthoalkylphenyl ketones, studied from similar perspective for more than two decades.

  4. 27 CFR 1.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., Delegation of the Administrator's Authorities in 27 CFR Part 1, Basic Permit Requirements Under the Federal... Administrator. 1.4 Section 1.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Delegations of the Administrator. Most of the regulatory authorities of the Administrator contained in...

  5. 27 CFR 1.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., Delegation of the Administrator's Authorities in 27 CFR Part 1, Basic Permit Requirements Under the Federal... Administrator. 1.4 Section 1.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Delegations of the Administrator. Most of the regulatory authorities of the Administrator contained in...

  6. 27 CFR 1.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., Delegation of the Administrator's Authorities in 27 CFR Part 1, Basic Permit Requirements Under the Federal... Administrator. 1.4 Section 1.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Delegations of the Administrator. Most of the regulatory authorities of the Administrator contained in...

  7. 7 CFR 1.4 - Public access to certain materials.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Public access to certain materials. 1.4 Section 1.4... do, and how a member of the public can use it to access government records. The handbook should be... with paragraph (a)(4) of this section in situations where public access in a timely manner is...

  8. 7 CFR 1.4 - Public access to certain materials.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Public access to certain materials. 1.4 Section 1.4... do, and how a member of the public can use it to access government records. The handbook should be... with paragraph (a)(4) of this section in situations where public access in a timely manner is...

  9. 43 CFR 3864.1-4 - Proof of nonmineral character.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Proof of nonmineral character. 3864.1-4 Section 3864.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS...

  10. 43 CFR 3864.1-4 - Proof of nonmineral character.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Proof of nonmineral character. 3864.1-4 Section 3864.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MINERAL PATENT APPLICATIONS...

  11. Cross-Cycloaddition of Two Different Isocyanides: Chemoselective Heterodimerization and [3+2]-Cyclization of 1,4-Diazabutatriene.

    PubMed

    Hu, Zhongyan; Yuan, Haiyan; Men, Yang; Liu, Qun; Zhang, Jingping; Xu, Xianxiu

    2016-06-13

    A new cross-cycloaddition reaction between a wide range of isocyanides and 2-isocyanochalcones (or analogues) was developed for the expeditious synthesis of pyrrolo[3,4-b]indoles under thermal conditions. On the basis of the experimental results and DFT calculations, a mechanism for this domino reaction is proposed involving chemoselective heterodimerization of two different isocyanides to form 1,4-diazabutatriene intermediates, followed by an intramolecular [3+2]-cycloaddition and 1,3-proton shift. PMID:27135199

  12. First acceleration of a proton beam in a side coupled drift tube linac

    NASA Astrophysics Data System (ADS)

    Ronsivalle, C.; Picardi, L.; Ampollini, A.; Bazzano, G.; Marracino, F.; Nenzi, P.; Snels, C.; Surrenti, V.; Vadrucci, M.; Ambrosini, F.

    2015-07-01

    We report the first experiment aimed at the demonstration of low-energy protons acceleration by a high-efficiency S-band RF linear accelerator. The proton beam has been accelerated from 7 to 11.6 MeV by a 1 meter long SCDTL (Side Coupled Drift Tube Linac) module powered with 1.3 MW. The experiment has been done in the framework of the Italian TOP-IMPLART (Oncological Therapy with Protons-Intensity Modulated Proton Therapy Linear Accelerator for Radio-Therapy) project devoted to the realization of a proton therapy centre based on a proton linear accelerator for intensity modulated cancer treatments to be installed at IRE-IFO, the largest oncological hospital in Rome. It is the first proton therapy facility employing a full linear accelerator scheme based on high-frequency technology.

  13. Target designs for the Brookhaven National Laboratory 5-MW pulsed spallation neutron source

    SciTech Connect

    Ludewig, H.; Todosow, M.; Powell, J.R.

    1996-03-01

    A feasibility study of a compact high power density target for a spallation neutron source was under-taken. The target arrangement consists primarily of heavy metal, with appropriate cooling passages. A high intensity proton beam of intermediate energy is directed at the target, where it interacts with the heavy metal nuclei. The subsequent spallation reactions produce several neutrons per proton resulting in an intense neutron source. The proton beam is assumed to havean energy of 5 MW, and to be cyclic with a repetition rate of 10Hz and 50Hz. The study was divided into two broad sections. First, an analysis of preliminary target designs was undertaken to ensure the overall feasibility of the concepts involved in the design and eventual construction of such a high power density target. Second, two proposed target designs, based on the first set of analyses, are investigated in more detail. Special care is taken to ensure that the neutron fluxes in the moderator are at the desired level no material compatibility problems exist,and the target is able to operate in a reliable and safe manner. Several target materials, coolant types, and target arrangements are investigated in the first section. The second section concentrates on a single target material and geometric arrangement. However, several structural material choices continue to be investigated with the aim of minimizing the effects of structural heating, and associated thermally induced stresses. In the final section the conclusions of this preliminary study are summarized.

  14. Economic Benefits, Carbon Dioxide (CO2) Emissions Reductions, and Water Conservation Benefits from 1,000 Megawatts (MW) of New Wind Power in Massachusetts (Fact Sheet)

    SciTech Connect

    Lantz, E.; Tegen, S.

    2009-03-01

    The U.S. Department of Energy?s Wind Powering America Program is committed to educating state-level policymakers and other stakeholders about the economic, CO2 emissions, and water conservation impacts of wind power. This analysis highlights the expected impacts of 1000 MW of wind power in Massachusetts. Although construction and operation of 1000 MW of wind power is a significant effort, seven states have already reached the 1000-MW mark. We forecast the cumulative economic benefits from 1000 MW of development in Massachusetts to be $1.4 billion, annual CO2 reductions are estimated at 2.6 million tons, and annual water savings are 1,293 million gallons.

  15. 21 CFR 177.1240 - 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate copolymer. 177.1240 Section 177.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES:...

  16. 21 CFR 177.1240 - 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate copolymer. 177.1240 Section 177.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR...

  17. 21 CFR 177.1240 - 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate copolymer. 177.1240 Section 177.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) INDIRECT FOOD...

  18. 21 CFR 177.1240 - 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate copolymer. 177.1240 Section 177.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION (CONTINUED) INDIRECT FOOD ADDITIVES:...

  19. Construction, completion, and testing of replacement monitoring wells MW 3-2, MW 6-2, MW 7-2, and MW 11-2, Mountain Home Air Force Base, Idaho, February through April 2000

    USGS Publications Warehouse

    Parliman, D.J.

    2000-01-01

    In February and March 2000, the U.S. Geological Survey Western Regional Research Drilling Operation constructed replacement monitoring wells MW 3–2, MW 6–2, MW 7–2, and MW 11–2 as part of a regional ground-water monitor- ing network for the Mountain Home Air Force Base, Elmore County, Idaho. Total well depths ranged from 435.5 to 456.5 feet, and initial depth-to-water measurements ranged from about 350 to 375 feet below land surface. After completion, wells were pumped and onsite measurements were made of water temperature, specific conductance, pH, and dissolved oxygen. At each well, natural gamma, spontaneous potential, resistivity, caliper, and temperature logs were obtained from instruments placed in open boreholes. A three- dimensional borehole flow analysis was completed for MW 3–2 and MW 11–2, and a video log was obtained for MW 11–2 to annotate lithology and note wet zones in the borehole above saturated rock.

  20. Elastic proton-proton scattering at RHIC

    SciTech Connect

    Yip, K.

    2011-09-03

    Here we describe elastic proton+proton (p+p) scattering measurements at RHIC in p+p collisions with a special optics run of {beta}* {approx} 21 m at STAR, at the center-of-mass energy {radical}s = 200 GeV during the last week of the RHIC 2009 run. We present preliminary results of single and double spin asymmetries.

  1. What's In a Proton?

    ScienceCinema

    Brookhaven Lab

    2010-01-08

    Physicist Peter Steinberg explains that fundamental particles like protons are themselves made up of still smaller particles called quarks. He discusses how new particles are produced when quarks are liberated from protons...a process that can be observed

  2. Proton pump inhibitors

    MedlinePlus

    Proton pump inhibitors (PPIs) are medicines that work by reducing the amount of stomach acid made by glands in ... Proton pump inhibitors are used to: Relieve symptoms of acid reflux, or gastroesophageal reflux disease (GERD). This is a ...

  3. What's In a Proton?

    SciTech Connect

    Brookhaven Lab

    2009-07-08

    Physicist Peter Steinberg explains that fundamental particles like protons are themselves made up of still smaller particles called quarks. He discusses how new particles are produced when quarks are liberated from protons...a process that can be observed

  4. VIEW OF #1 #4 EXCITER AND GENERATORFIELD RHEOSTATS WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF #1 - #4 EXCITER AND GENERATOR-FIELD RHEOSTATS WITH RESISTOR BANKS ON EAST END OF GENERATOR FLOOR. PHOTO BY JET LOWE, HAER, 1995. - Elwha River Hydroelectric System, Elwha Hydroelectric Dam & Plant, Port Angeles, Clallam County, WA

  5. Dielectric properties of multiatomic alcohols: 1,4-butanediol

    NASA Astrophysics Data System (ADS)

    Zhuravlev, V. I.

    2015-12-01

    The dielectric spectra of 1,4-butanediol in the temperature range of 298-423 K are analyzed using the theoretical approaches of Debye, Davidson-Cole, and Forsman, based on the Dissado-Hill theory. It is shown that the dielectric spectra of 1,4-butanediol are described by the Davidson-Cole equation, and the βDC parameter has a pronounced strong temperature dependence. In the Debye theory, the spectrum of the dielectric relaxation of 1,4-butanediol is presented as the sum of two region of dispersions. Conclusions are reached as to the possible mechanisms of dispersion responsible for the obtained regions. The relaxation times of 1,4-butanediol calculated using different equations describing the nonlinear behavior of the relaxation time are compared. The dipole moments of clusters are obtained for the first time and a preliminary analysis is performed using the Dissado-Hill cluster model.

  6. Proton: the particle.

    PubMed

    Suit, Herman

    2013-11-01

    The purpose of this article is to review briefly the nature of protons: creation at the Big Bang, abundance, physical characteristics, internal components, and life span. Several particle discoveries by proton as the experimental tool are considered. Protons play important roles in science, medicine, and industry. This article was prompted by my experience in the curative treatment of cancer patients by protons and my interest in the nature of protons as particles. The latter has been stimulated by many discussions with particle physicists and reading related books and journals. Protons in our universe number ≈10(80). Protons were created at 10(-6) -1 second after the Big Bang at ≈1.37 × 10(10) years beforethe present. Proton life span has been experimentally determined to be ≥10(34) years; that is, the age of the universe is 10(-24)th of the minimum life span of a proton. The abundance of the elements is hydrogen, ≈74%; helium, ≈24%; and heavier atoms, ≈2%. Accordingly, protons are the dominant baryonic subatomic particle in the universe because ≈87% are protons. They are in each atom in our universe and thus involved in virtually every activity of matter in the visible universe, including life on our planet. Protons were discovered in 1919. In 1968, they were determined to be composed of even smaller particles, principally quarks and gluons. Protons have been the experimental tool in the discoveries of quarks (charm, bottom, and top), bosons (W(+), W(-), Z(0), and Higgs), antiprotons, and antineutrons. Industrial applications of protons are numerous and important. Additionally, protons are well appreciated in medicine for their role in radiation oncology and in magnetic resonance imaging. Protons are the dominant baryonic subatomic particle in the visible universe, comprising ≈87% of the particle mass. They are present in each atom of our universe and thus a participant in every activity involving matter. PMID:24074929

  7. Proton: The Particle

    SciTech Connect

    Suit, Herman

    2013-11-01

    The purpose of this article is to review briefly the nature of protons: creation at the Big Bang, abundance, physical characteristics, internal components, and life span. Several particle discoveries by proton as the experimental tool are considered. Protons play important roles in science, medicine, and industry. This article was prompted by my experience in the curative treatment of cancer patients by protons and my interest in the nature of protons as particles. The latter has been stimulated by many discussions with particle physicists and reading related books and journals. Protons in our universe number ≈10{sup 80}. Protons were created at 10{sup −6} –1 second after the Big Bang at ≈1.37 × 10{sup 10} years beforethe present. Proton life span has been experimentally determined to be ≥10{sup 34} years; that is, the age of the universe is 10{sup −24}th of the minimum life span of a proton. The abundance of the elements is hydrogen, ≈74%; helium, ≈24%; and heavier atoms, ≈2%. Accordingly, protons are the dominant baryonic subatomic particle in the universe because ≈87% are protons. They are in each atom in our universe and thus involved in virtually every activity of matter in the visible universe, including life on our planet. Protons were discovered in 1919. In 1968, they were determined to be composed of even smaller particles, principally quarks and gluons. Protons have been the experimental tool in the discoveries of quarks (charm, bottom, and top), bosons (W{sup +}, W{sup −}, Z{sup 0}, and Higgs), antiprotons, and antineutrons. Industrial applications of protons are numerous and important. Additionally, protons are well appreciated in medicine for their role in radiation oncology and in magnetic resonance imaging. Protons are the dominant baryonic subatomic particle in the visible universe, comprising ≈87% of the particle mass. They are present in each atom of our universe and thus a participant in every activity involving matter.

  8. High-power targets: experience and R&D for 2 MW

    SciTech Connect

    Hurh, P.; Caretta, O.; Davenne, T.; Densham, C.; Loveridge, P.; Simos, N.; /Brookhaven

    2011-03-01

    High-power particle production targets are crucial elements of future neutrino and other rare particle beams. Fermilab plans to produce a beam of neutrinos (LBNE) with a 2.3 MW proton beam (Project X). Any solid target is unlikely to survive for an extended period in such an environment - many materials would not survive a single beam pulse. We are using our experience with previous neutrino and antiproton production targets, along with a new series of R&D tests, to design a target that has adequate survivability for this beamline. The issues considered are thermal shock (stress waves), heat removal, radiation damage, radiation accelerated corrosion effects, physics/geometry optimization and residual radiation.

  9. Recent Performance of the SNS H-Source for 1-MW Neutron Production

    SciTech Connect

    Stockli, Martin P; Han, Baoxi; Murray Jr, S N; Pennisi, Terry R; Santana, Manuel; Welton, Robert F

    2013-01-01

    This paper describes the performance of the SNS ion source and LEBT as they continue to deliver ~50 mA H- beams at a 5.3% duty factor required for neutron production with a ~1MW proton beam since the fall of 2009. The source continues to deliver persistent H- beams for up to 6 weeks without adding Cs after an initial dose of ~4 mg, except when there are excessive plasma impurities. In one case the H- beam decayed due to an air leak, which is shown to be consistent with sputtering of the Cs layer, and which allows to bracket the plasma potential. In another case, the performance of two sources degraded progressively, which appears to be consistent with a progressive deterioration of the Cs covered Mo converter. These two and other recently discovered issues are discussed in detail.

  10. Inelastic scattering research at a 1 MW long pulse spallation neutron source

    SciTech Connect

    Carlile, C.J.

    1995-12-31

    The brief was, with respect to the LPSS bench mark design supplied (60 Hz, 1 MW, Imsec proton pulse, with a split, non-fissile target and 4 moderators in a flux trap geometry design), to identify a set of instruments, and to assess their performance with respect to existing spectrometers on other sources. Any modifications to the existing instruments which would make them more effective on the bench-mark source, or conversely, any modifications to the source bench-mark required by the proposed instruments were to be identified, as were any uncertainties in the estimated performances, or any R & D needed to make the proposed instruments viable. Any new instrument concepts specifically matched to the long pulse itself were to be identified and assessed. This process was to result in an indicative list of instruments for the source. A figure of around 10 spectrometers was to be aimed for.

  11. Two-proton radioactivity of 45Fe

    SciTech Connect

    Miernik, K.; Dominik, W.; Janas, Z.; Pfutzner, M.; Grigorenko, L.; Bingham, C. R.; Czyrkowski, H.; Cwiok, Mikolaj; Darby, Iain; Dabrowski, Ryszard; Ginter, T. N.; Grzywacz, R.; Karny, M.; Korgul, A.; Kusmierz, W.; Liddick, Sean; Rajabali, Mustafa; Rykaczewski, Krzysztof Piotr; Stolz, A.

    2009-01-01

    In an experiment at the SISSI-LISE3 facility of GANIL, the decay of the proton drip line nucleus 45Fe has been studied. Fragment-implantation events have been correlated with radioactive decay events in a 16x16 pixel silicon-strip detector. The decay-energy spectrum of 45Fe implants shows a distinct peak at (1.14+/-0.04) MeV with a half-life of T(1/2)=(4.7(+3.4)(-1.4)) ms. None of the events in this peak is in coincidence with beta particles. For a longer correlation interval, daughter decays of the two-proton daughter 43Cr can be observed after 45Fe implantation. The decay energy for 45Fe agrees nicely with several theoretical predictions for two-proton radioactivity.

  12. 21 CFR 177.1240 - 1,4-Cyclohexylene dimethylene terephthalate and 1,4-cyclohexylene dimethylene isophthalate...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... condensation of dimethyl terephthalate and dimethyl isophthalate with 1,4-cyclohexanedimethanol, to which may...) The copolymer, when extracted with distilled water at reflux temperature for 2 hours, yields...

  13. The DIII-D 3 MW, 110 GHz ECH system

    SciTech Connect

    Callis, R. W.; Lohr, J.; Ponce, D.; O'Neill, R. C.; Prater, R.; Luce, T. C.

    1999-09-20

    Three 110 GHz gyrotrons with nominal output power of 1 MW each have been installed and are operational on the DIII-D tokamak. One gyrotron is built by Gycom and has a nominal rating of 1 MW and a 2 s pulse length, with the pulse length being determined by the maximum temperature allowed on the edge cooled Boron Nitride window. The second and third gyrotrons were built by Communications and Power Industries (CPI). The first CPI gyrotron uses a double disc FC-75 cooled sapphire window which has a pulse length rating of 0.8 s at 1 MW, 2 s at 0.5 MW and 10 s at 0.35 MW. The second CPI gyrotron, utilizes a single disc chemical-vapor-deposition diamond window, that employs water cooling around the edge of the disc. Calculation predict that the diamond window should be capable of full 1 MW cw operation. All gyrotrons are connected to the tokamak by a low-loss-windowless evacuated transmission line using circular corrugated waveguide for propagation in the HE{sub 11} mode. Each waveguide system incorporates a two mirror launcher which can steer the rf beam poloidally from the center to the outer edge of the plasma. Central current drive experiments with the two gyrotrons with 1.5 MW of injected power drove about 0.17 MA. Results from using the three gyrotron systems will be reported as well as the plans to upgrade the system to 6 MW. (c) 1999 American Institute of Physics.

  14. H-1 Dynamic Nuclear Polarization in Supercritical Ethylene at 1.4 T

    SciTech Connect

    Wind, Robert A. ); Shi, Bai; Hu, Jian Zhi ); Solum, Mark S.; Ellis, Paul D. ); Grant, David M.; Pugmire, Ronald J.; Taylor, Craig M.; Yonker, Clement R. )

    2000-03-01

    H1 dynamic nuclear polarization (DNP) has been measured in supercritical ethylene in the pressure range 60-300 bar and in an external field of 1.4 T. A single-cell sapphire tube was used as a high pressure cell and powdered 1,3-bisdiphenylene-2-phenyl allyl(BDPA) free radicals were added and distributed at the wall of the cell. At all pressures the dominant DNP effect was a positive Overhauser enhancement, caused by proton-electron contact interactions at the fluid/solid radical interface. The observed enhancements varied from 12 at 67 bar to 17 at 300 bar. Besides the Overhauser enhancement, also a small solid state and thermal mixing enhancement were observed, indicating that part of the ethylene is absorbed at the radical surface for a prolonged time. These data indicate that DNP-enhanced NMR has the potential of extending the impact of NMR in research areas involving supercritical fluids.

  15. Study of proton radioactivities

    SciTech Connect

    Davids, C.N.; Back, B.B.; Henderson, D.J.

    1995-08-01

    About a dozen nuclei are currently known to accomplish their radioactive decay by emitting a proton. These nuclei are situated far from the valley of stability, and mark the very limits of existence for proton-rich nuclei: the proton drip line. A new 39-ms proton radioactivity was observed following the bombardment of a {sup 96}Ru target by a beam of 420-MeV {sup 78}Kr. Using the double-sided Si strip detector implantation system at the FMA, a proton group having an energy of 1.05 MeV was observed, correlated with the implantation of ions having mass 167. The subsequent daughter decay was identified as {sup 166}Os by its characteristic alpha decay, and therefore the proton emitter is assigned to the {sup 167}Ir nucleus. Further analysis showed that a second weak proton group from the same nucleus is present, indicating an isomeric state. Two other proton emitters were discovered recently at the FMA: {sup 171}Au and {sup 185}Bi, which is the heaviest known proton radioactivity. The measured decay energies and half-lives will enable the angular momentum of the emitted protons to be determined, thus providing spectroscopic information on nuclei that are beyond the proton drip line. In addition, the decay energy yields the mass of the nucleus, providing a sensitive test of mass models in this extremely proton-rich region of the chart of the nuclides. Additional searches for proton emitters will be conducted in the future, in order to extend our knowledge of the location of the proton drip line.

  16. Regioselective oxidation of unprotected 1,4 linked glucans.

    PubMed

    Eisink, Niek N H M; Lohse, Jonas; Witte, Martin D; Minnaard, Adriaan J

    2016-06-01

    Palladium-catalyzed alcohol oxidation allows the chemo- and regioselective modification of unprotected 1,4 linked glucans. This is demonstrated in the two-step bisfunctionalization of 1,4 linked glucans up to the 7-mer. Introduction of an anomeric azide is followed by a highly regioselective mono-oxidation of the terminal C3-OH functionality. The resulting orthogonal bis-functionalized oligosaccharides are a viable alternative to PEG-spacers as demonstrated in the conjugation of a cysteine mutant of 4-oxalocrotonate tautomerase with biotin. PMID:27159790

  17. Canonical representations of the Lie superalgebra osp(1,4)

    NASA Astrophysics Data System (ADS)

    Blank, J.; Havlíček, M.; Bednář, M.; Lassner, W.

    1981-11-01

    The method for constructing infinite-dimensional representations of Lie superalgebras proposed by the authors recently is applied to the superalgebra osp (1, 4). Explicit formulae for its generators in terms of two or three pairs of operators fulfilling the canonical commutation relations, at most one pair of operators fulfilling the canonical anticommutation relations and at most one real parameter are obtained. The generators of the Lie subalgebra sp (4, ℝ) ⊂ osp (1,4) are represented skew-symmetrically and both the Casimir operators are equal to multiples of the unity operator.

  18. Solar gamma-ray lines and interplanetary solar protons

    NASA Astrophysics Data System (ADS)

    Yoshimori, M.

    1985-03-01

    Solar gamma-ray lines and protons were simultaneously observed for six flares on April 1, 4, and 27, 1981, May 13, 1981, February 1, 1982, and June 6, 1982 by the Hinotori and Himawari satellites. The flare list is presented, and the time histories of gamma-rays and protons are shown. The relationship between the gamma-ray line fluences and peak proton fluxes for these flares does not reveal an apparent correlation between them. The present results imply that the protons producing gamma-ray lines in the flare region, and protons observed near the earth, do not always belong to the same population, and favor the downward streaming model for the gamma-ray line production.

  19. A New High-Current Proton Accelerator

    SciTech Connect

    Cleland, M. R.; Galloway, R. A.; DeSanto, L.; Jongen, Y.

    2009-03-10

    A high-current (>20 mA) dc proton accelerator is being developed for applications such as boron neutron capture therapy (BNCT) and the detection of explosive materials by nuclear resonance absorption (NRA) of gamma radiation. The high-voltage dc accelerator (adjustable between 1.4 and 2.8 MeV) will be a single-ended industrial Dynamitron registered system equipped with a compact high-current, microwave-driven proton source. A magnetic mass analyzer inserted between the ion source and the acceleration tube will select the protons and reject heavier ions. A sorption pump near the ion source will minimize the flow of neutral hydrogen gas into the acceleration tube. For BNCT, a lithium target for generating epithermal neutrons is being developed that will be capable of dissipating the high power (>40 kW) of the proton beam. For NRA, special targets will be used to generate gamma rays with suitable energies for exciting nuclides typically present in explosive materials. Proton accelerators with such high-current and high-power capabilities in this energy range have not been developed previously.

  20. A New High-Current Proton Accelerator

    NASA Astrophysics Data System (ADS)

    Cleland, M. R.; Galloway, R. A.; DeSanto, L.; Jongen, Y.

    2009-03-01

    A high-current (>20 mA) dc proton accelerator is being developed for applications such as boron neutron capture therapy (BNCT) and the detection of explosive materials by nuclear resonance absorption (NRA) of gamma radiation. The high-voltage dc accelerator (adjustable between 1.4 and 2.8 MeV) will be a single-ended industrial Dynamitron® system equipped with a compact high-current, microwave-driven proton source. A magnetic mass analyzer inserted between the ion source and the acceleration tube will select the protons and reject heavier ions. A sorption pump near the ion source will minimize the flow of neutral hydrogen gas into the acceleration tube. For BNCT, a lithium target for generating epithermal neutrons is being developed that will be capable of dissipating the high power (>40 kW) of the proton beam. For NRA, special targets will be used to generate gamma rays with suitable energies for exciting nuclides typically present in explosive materials. Proton accelerators with such high-current and high-power capabilities in this energy range have not been developed previously.

  1. 17 CFR 1.4 - Use of electronic signatures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Use of electronic signatures... REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.4 Use of electronic signatures. For purposes of... pool participant or a client of a commodity trading advisor, an electronic signature executed by...

  2. 13. Engine room, view of Ames aniflow (engine #1). 4 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Engine room, view of Ames aniflow (engine #1). 4 cylinder-1953, centrifuge oil separator in foreground, doorway to machine shop on right in background, taken from southeast - East Boston Pumping Station, Chelsea Street at Chelsea Creek, Boston, Suffolk County, MA

  3. 17 CFR 1.4 - Use of electronic signatures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Use of electronic signatures... REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.4 Use of electronic signatures. For purposes of... broker, a pool participant or a client of a commodity trading advisor, an electronic signature...

  4. 17 CFR 1.4 - Use of electronic signatures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Use of electronic signatures... REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Definitions § 1.4 Use of electronic signatures. For purposes of... pool participant or a client of a commodity trading advisor, an electronic signature executed by...

  5. Sunspot 1520 Releases Strong (X1.4) Solar Flare

    NASA Video Gallery

    This movie shows the sun July 10-12, ending with the X1.4 class flare on July 12, 2012. It was captured by NASA’s Solar Dynamics Observatory in the 131 Angstrom wavelength - a wavelength that is...

  6. 43 CFR 3425.1-4 - Emergency leasing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Emergency leasing. 3425.1-4 Section 3425.1... Emergency leasing. (a) An emergency lease sale may be held in response to an application under this subpart... Governor of the affected State(s) a notice of an emergency lease application when it is filed with...

  7. An MW-based Historical Earthquake Catalog for Mainland China

    NASA Astrophysics Data System (ADS)

    Cheng, J.; Rong, Y.; Magistrale, H.; Chen, G.; Xu, X.

    2015-12-01

    China has a nearly 3,000-year long earthquake record. As a step to develop seismic hazard maps for mainland China, we compiled a homogeneous MW-based historical earthquake catalog. We started from an MS-based Chinese catalog spanning from 780 B.C. to present. We compared MS from the catalog with Mw for common earthquakes in the ISC-GEM and GCMT catalogs, and derived MS- MW regression relationships using orthogonal least square method. We derived regression relationships for different time periods considering the following factors: 1) Chinese seismograph network density has been improved with time; 2) the methodology for determining earthquake magnitude and location in the Chinese catalog has changed through time; and 3) different seismographs were used in different times. We also derived separate regression relationships for small and large events since the parameters of large events are usually reevaluated in the Chinese catalog. For events included in the ISC-GEM or GCMT catalogs, we use the location and magnitude from those catalogs. For other events, we used the location from the Chinese catalog and the converted MW. The final catalog has about 5,000 earthquakes of MW 4.5 and larger. The catalog is more complete for eastern China than western China because eastern China has much longer history of human settlement. Key words Earthquake catalog in mainland China, Surface magnitude, Moment magnitude, orthogonal regression.

  8. Startup, Commissioning and Operation of Fenyi 100MW CFB Boiler

    NASA Astrophysics Data System (ADS)

    Wang, Zhiwei; Yu, Wugao; Bo, Shi

    The first 100MW CFB boiler, designed by the Thermal Power Research Institute and manufactured by Harbin Boiler Company Limited, has been successfully running in Jiangxi Fenyi Power Plant since 2003. Local high ash content anthracite and lean coal that are very difficult to burn out are used in the 100 MW CFB boiler. The results of the 100MW CFB boiler shows that the CFB boiler can run in 30% MCR and startup with two under bed burners, and the boiler efficiency higher than 88% can be got after the combustion modification test. The CFB boiler can be operated with full load and reaches design parameters. The emissions of NO, N2O and CO are less than 7Omg/m3, 30mg/m3, and 125mg/m3, respectively, and SO2 less than 400mg/m3 after limestone injection. The bottom ash temperature from bed ash coolers is less than 120°C after its modification. Coal blockage at the coal storage silo is the main problem influencing the CFB boiler continuous operation. The running experiences for 5 years proved that the CFB boiler performance is successful, and the results were applied in 210 MW and 330 MW CFB Boiler design of Fenyi Power Plant.

  9. Latest Results in SLAC 75-MW PPM Klystrons

    SciTech Connect

    Sprehn, D.; Caryotakis, G.; Haase, A.; Jongewaard, E.; Laurent, L.; Pearson, C.; Phillips, R.; /SLAC

    2006-03-06

    75 MW X-band klystrons utilizing Periodic Permanent Magnet (PPM) focusing have been undergoing design, fabrication and testing at the Stanford Linear Accelerator Center (SLAC) for almost nine years. The klystron development has been geared toward realizing the necessary components for the construction of the Next Linear Collider (NLC). The PPM devices built to date which fit this class of operation consist of a variety of 50 MW and 75 MW devices constructed by SLAC, KEK (Tsukuba, Japan) and industry. All these tubes follow from the successful SLAC design of a 50 MW PPM klystron in 1996. In 2004 the latest two klystrons were constructed and tested with preliminary results reported at EPAC2004. The first of these two devices was tested to the full NLC specifications of 75 MW, 1.6 microseconds pulse length, and 120 Hz. This 14.4 kW average power operation came with a tube efficiency >50%. The most recent testing of these last two devices will be presented here. Design and manufacturing issues of the latest klystron, due to be tested by the Fall of 2005, are also discussed.

  10. Proton-conducting cerate ceramics

    SciTech Connect

    Pederson, L.R.; Coffey, G.W.; Bates, J.L.; Weber, W.J.

    1996-08-01

    Single-cell solid oxide fuel cells were constructed using strontium cerate as the electrolyte and their performance tested. Like certain zirconates, hafnates, and tantalates, the cerate perovskites are among a class of solid electrolytes that conduct protons at elevated temperatures. Depending on the temperature and chemical environment, these ceramics also support electronic and oxygen ion currents. A maximum power output of {approx}100 mW per cm{sup 2} electrolyte surface area was obtained at 900{degrees}C using 4% hydrogen as the fuel and air as the oxidant. A series of rare earth/ceria/zirconia were prepared and their electrical properties characterized. Rare earth dopants included ytterbia, yttria, terbia, and europia. Ionic conductivities were highest for rare earth/ceria and rare earth zirconia compositions; a minimum in ionic conductivity for all series were found for equimolar mixtures of ceria and zirconia. Cerium oxysulfide is of interest in fossil energy applications because of its high chemical stability and refractory nature. An alternative synthesis route to preparing cerium oxysulfide powders has been developed using combustion techniques.

  11. Ab Initio Investigation of Cation Proton Affinity and Proton Transfer Energy for Energetic Ionic Liquids.

    PubMed

    Carlin, Caleb M; Gordon, Mark S

    2016-08-01

    Protonation of the anion in an ionic liquid plays a key role in the hypergolic reaction between ionic liquids and oxidizers such as white fuming nitric acid. To investigate the influence of the cation on the protonation reaction, the deprotonation energy of a set of cations has been calculated at the MP2 level of theory. Specifically, guanidinium, dimethyltriazanium, triethylamine, N-ethyl-N-methyl-pyrrolidinium, N-ethyl-pyridinium, 1,4-dimethyl-1,2,4-triazolium, 1-ethyl-4-methyl-1,2,4-triazolium, and 1-butyl-4-methyl-1,2,4-triazolium were studied. In addition, the net proton transfer energies from the cations to a set of previously studied anions was calculated, demonstrating an inverse correlation between the net proton transfer energy and the likelihood that the cation/anion combination will react hypergolically with white fuming nitric acid. It is suggested that this correlation occurs due to a balance between the energy released by the proton transfer and the rate of proton transfer as determined by the ionicity of the ionic liquid. PMID:27397644

  12. Design of Electron Gun for 1.5 MW, 140 GHz Gyrotron

    NASA Astrophysics Data System (ADS)

    Singh, Udaybir; Kumar, Nitin; Purohit, L. P.; Sinha, A. K.

    2011-02-01

    This paper presents the design of the triode type electron gun for a 140 GHz, 1.5 MW gyrotron with the transverse to the axial velocity ratio of the beam 1.4 and the transverse velocity spread 1.28%. The operating mode of the gyrotron is TE24,8 and it is operated in the fundamental harmonic. The analytic trade-off equations for the electron gun design have been used to estimate the initial gun parameters. The electron trajectory tracing program has been used to optimize the electron gun design. The parametric dependences of modulating anode voltage, beam voltage and cathode magnetic field on the beam quality has also been studied.

  13. The 1.5 MW wind turbine of tomorrow

    SciTech Connect

    De Wolff, T.J.; Sondergaard, H.

    1996-12-31

    The Danish company Nordtank is one of the pioneers within the wind turbine industry. Since 1981 Nordtank has installed worldwide more than 2300 wind turbine generators with a total name plate capacity that is exceeding 350 MW. This paper will describe two major wind turbine technology developments that Nordtank has accomplished during the last year: Site Optimization of Nordtank wind turbines: Nordtank has developed a flexible design concept for its WTGs in the 500/600 kW range, in order to offer the optimal WTG solution for any given site and wind regime. Nordtank`s 1.5 MW wind turbine: In September 1995, Nordtank was the first company to install a commercial 1.5 NM WTG. This paper will document the development process, the design as well as operations of the Nordtank 1.5 MW WTG.

  14. Solubility of carbon monoxide in 1,4-dioxane

    SciTech Connect

    Veleckis, E.; Hacker, D.S.

    1984-01-01

    The solubility of CO in 1,4-dioxane was determined as a function of pressure (7-70 atm) and temperature (80-173/sup 0/C). An expression is given for solubility that relates the mole fraction and partial pressure of CO (in atmospheres) and the temperature in degrees Kelvin. The results, analyzed in terms of the Krichevsky-Ilinskaya equation, showed that the partial molar volume of CO was independent of pressure and that the isobaric Henry's law was obeyed in the ranges studied. Comparisons with other solvents showed that, on the basis of CO dissolution characteristics, 1,4-dioxane can be classified better with polar than with nonpolar solvents.

  15. Ambiphilic boron in 1,4,2,5-diazadiborinine

    PubMed Central

    Wang, Baolin; Li, Yongxin; Ganguly, Rakesh; Hirao, Hajime; Kinjo, Rei

    2016-01-01

    Boranes have long been known as the archetypal Lewis acids owing to an empty p-orbital on the boron centre. Meanwhile, Lewis basic tricoordinate boranes have been developed in recent years. Here we report the synthesis of an annulated 1,4,2,5-diazadiborinine derivative featuring boron atoms that exhibit both Lewis acidic and basic properties. Experimental and computational studies confirmed that two boron atoms in this molecule are spectroscopically equivalent. Nevertheless, this molecule cleaves C–O, B–H, Si–H and P–H bonds heterolytically, and readily undergoes [4+2] cycloaddition reaction with non-activated unsaturated bonds such as C=O, C=C, C≡C and C≡N bonds. The result, thus, indicates that the indistinguishable boron atoms in 1,4,2,5-diazadiborinine act as both nucleophilic and electrophilic centres, demonstrating ambiphilic nature. PMID:27279265

  16. Ambiphilic boron in 1,4,2,5-diazadiborinine.

    PubMed

    Wang, Baolin; Li, Yongxin; Ganguly, Rakesh; Hirao, Hajime; Kinjo, Rei

    2016-01-01

    Boranes have long been known as the archetypal Lewis acids owing to an empty p-orbital on the boron centre. Meanwhile, Lewis basic tricoordinate boranes have been developed in recent years. Here we report the synthesis of an annulated 1,4,2,5-diazadiborinine derivative featuring boron atoms that exhibit both Lewis acidic and basic properties. Experimental and computational studies confirmed that two boron atoms in this molecule are spectroscopically equivalent. Nevertheless, this molecule cleaves C-O, B-H, Si-H and P-H bonds heterolytically, and readily undergoes [4+2] cycloaddition reaction with non-activated unsaturated bonds such as C=O, C=C, C≡C and C≡N bonds. The result, thus, indicates that the indistinguishable boron atoms in 1,4,2,5-diazadiborinine act as both nucleophilic and electrophilic centres, demonstrating ambiphilic nature. PMID:27279265

  17. Ruthenium-Catalyzed Regioselective 1,4-Hydroboration of Pyridines.

    PubMed

    Kaithal, Akash; Chatterjee, Basujit; Gunanathan, Chidambaram

    2016-07-15

    Simple ruthenium precursor [Ru(p-cymene)Cl2]2 1 catalyzed regioselective 1,4-dearomatization of pyridine derivatives using pinacolborane is reported. Two catalytic intermediates, [Ru(p-cymene)Cl2Py] 2 and [Ru(p-cymene)Cl2(P(Cy)3)] 3, involved in this process are identified, independently synthesized, characterized, and further used directly as effective catalysts; two more catalytic intermediates [Ru(p-cymene)Cl2(Py)(P(Cy)3)] 4 and [Ru(p-cymene)(H)Cl(Py)(P(Cy)3)] 5 are identified in solution. Complex 5 is the active catalytic intermediate. An intramolecular selective 1,5-hydride transfer in 5 leading to the regioselective 1,4-hydroboration of pyridine compounds is proposed. PMID:27351256

  18. The Schwarzschild Proton

    SciTech Connect

    Haramein, Nassim

    2010-11-24

    We review our model of a proton that obeys the Schwarzschild condition. We find that only a very small percentage ({approx}10{sup -39}%) of the vacuum fluctuations available within a proton volume need be cohered and converted to mass-energy in order for the proton to meet the Schwarzschild condition. This proportion is equivalent to that between gravitation and the strong force where gravitation is thought to be {approx}10{sup -38} to 10{sup -40} weaker than the strong force. Gravitational attraction between two contiguous Schwarzschild protons can accommodate both nucleon and quark confinement. We calculate that two contiguous Schwarzschild protons would rotate at c and have a period of 10{sup -23} s and a frequency of 10{sup 22} Hz which is characteristic of the strong force interaction time and a close approximation of the gamma emission typically associated with nuclear decay. We include a scaling law and find that the Schwarzschild proton data point lies near the least squares trend line for organized matter. Using a semi-classical model, we find that a proton charge orbiting at a proton radius at c generates a good approximation to the measured anomalous magnetic moment.

  19. Electron-proton spectrometer

    NASA Technical Reports Server (NTRS)

    Winckler, J. R.

    1973-01-01

    An electron-proton spectrometer was designed to measure the geomagnetically trapped radiation in a geostationary orbit at 6.6 earth radii in the outer radiation belt. This instrument is to be flown on the Applications Technology Satellite-F (ATS-F). The electron-proton spectrometer consists of two permanent magnet surface barrier detector arrays and associated electronics capable of selecting and detecting electrons in three energy ranges: (1) 30-50 keV, (2) 150-200 keV, and (3) 500 keV and protons in three energy ranges. The electron-proton spectrometer has the capability of measuring the fluxes of electrons and protons in various directions with respect to the magnetic field lines running through the satellite. One magnet detector array system is implemented to scan between EME north and south through west, sampling the directional flux in 15 steps. The other magnet-detector array system is fixed looking toward EME east.

  20. Antineoplastic agents LXIV: 1,4-Bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dihydrogen dimaleate.

    PubMed

    Pettit, G R; Gieschen, D P; Pettit, W E

    1979-12-01

    The 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo[2.2.1]heptane dication (II) exhibits remarkable antineoplastic activity. Detailed evaluation of several dianion derivatives showed a curative response level against the murine P-388 lymphocytic leukemia, colon 26, CD8F1 mammary, and the Walker 256 carcinosarcoma (rat) tumor systems. In addition, significant cancer chemotherapeutic activity was found against the murine L-1210 lymphoid leukemia, colon 38, and B16 melanocarcinoma tumor systems. The bicyclo dication (II) first was isolated, evaluated, and stored as the diperchlorate derivative (IIa). Because of the promising anticancer activity of IIa, procedures were developed for obtaining other anion derivatives for comparative biological purposes. Several naturally occurring substances were evaluated, and the dihydrogen dimaleate derivative (IIi) obtained by an ion-exchange technique was the most suitable. PMID:529047

  1. THE BARRIERS TO RING ROTATION IN 1,1' ,4,4'-TETRA-t-BUTYLURANOCENE AND 1,1', 3,3'-TETRA-t-BUTYLFERROCENE

    SciTech Connect

    Luke, Wayne D.; Streitwieser, Jr., Andrew

    1980-10-01

    The {sup 1}H-NMR spectra of 1,1',4,4'~tetra-t~butyluranocene show a singlet for the t~butyl protons and three singlets for the ring protons. Coalescence occurs at -65 to -85°C with splitting of each peak at lower temperatures, corresponding to {Delta}G{sup {ne}} of rotation of 8.3 Kcal mol{sup -1} Coalescence was also observed for 1,1' ,3,3'- tetra-t~butylferrocene and a corresponding {Delta}G{sup {ne}} = 13.1 Kcal mol{sup 1} was obtained.

  2. MW 08-multi-beam air and surface surveillance radar

    NASA Astrophysics Data System (ADS)

    1989-09-01

    Signal of the Netherlands has developed and is marketing the MW 08, a 3-D radar to be used for short to medium range surveillance, target acquisition, and tracking. MW 08 is a fully automated detecting and tracking radar. It is designed to counter threats from aircraft and low flying antiship missiles. It can also deal with the high level missile threat. MW 08 operates in the 5 cm band using one antenna for both transmitting and receiving. The antenna is an array, consisting of 8 stripline antennas. The received radar energy is processed by 8 receiver channels. These channels come together in the beam forming network, in which 8 virtual beams are formed. From this beam pattern, 6 beams are used for the elevation coverage of 0-70 degrees. MW 08's output signals of the beam former are further handled by FFT and plot processors for target speed information, clutter rejection, and jamming suppression. A general purpose computer handles target track initiation, and tracking. Tracking data are transferred to the command and control systems with 3-D target information for fastest possible lockon.

  3. Lightweight MgB2 superconducting 10 MW wind generator

    NASA Astrophysics Data System (ADS)

    Marino, I.; Pujana, A.; Sarmiento, G.; Sanz, S.; Merino, J. M.; Tropeano, M.; Sun, J.; Canosa, T.

    2016-02-01

    The offshore wind market demands a higher power rate and more reliable turbines in order to optimize capital and operational costs. The state-of-the-art shows that both geared and direct-drive conventional generators are difficult to scale up to 10 MW and beyond due to their huge size and weight. Superconducting direct-drive wind generators are considered a promising solution to achieve lighter weight machines. This work presents an innovative 10 MW 8.1 rpm direct-drive partial superconducting generator using MgB2 wire for the field coils. It has a warm iron rotor configuration with the superconducting coils working at 20 K while the rotor core and the armature are at ambient temperature. A cooling system based on cryocoolers installed in the rotor extracts the heat from the superconducting coils by conduction. The generator's main parameters are compared against a permanent magnet reference machine, showing a significant weight and size reduction. The 10 MW superconducting generator concept will be experimentally validated with a small-scale magnetic machine, which has innovative components such as superconducting coils, modular cryostats and cooling systems, and will have similar size and characteristics as the 10 MW generator.

  4. Design of a 50 MW klystron at X-band

    SciTech Connect

    Wright, E.; Callin, R.; Caryotakis, G.

    1995-07-01

    This paper describes the design and performance of the XL-1 klystron; a 50 MW klystron operating at a frequency of 11.424 GHz for use on the SLAC Next Linear Collider Test Accelerator (NLCTA). Problems associated with the development of high-power rf sources for NLC, and the solutions implemented on XL-1 are discussed.

  5. Development of a 50 MW 30 GHz Gyroklystron Amplifier

    SciTech Connect

    Michael Read; Wesely Lawson, Lawrence Ives, Jeff Neilson

    2009-05-20

    DOE requires sources for testing of high gradient accelerator structures. A power of 50 MW is required at K and Ka band. The pulse length must be ~ 1 microsecond and the pulse repetition frequency at least 100 Hz. At least some applications may require phase stability not offered by a free running oscillator. CCR proposed to build a 50 MW 30 GHz gyrklystron amplifier. This approach would give the required phase stability. The frequency was at the second harmonic of the cycltron frequency and used the TE02 mode. This makes it possible to design a device without an inner conductor, and with a conventional (non-inverted) MIG. This minimizes cost and the risk due to mechanical alignment issues. A detailed design of the gyroklystron was produced. The design was based on simulations of the cavity(ies), electron gun, output coupler and output window. Two designs were produced. One was at the fundamental of the cyclotron frequency. Simulations predicted an output power of 72 MW with an efficiency of 48%. The other was at the second harmonic, producing 37 MW with an efficiency of 37%.

  6. Proton-proton colliding beam facility ISABELLE

    SciTech Connect

    Hahn, H

    1980-01-01

    This paper attempts to present the status of the ISABELLE construction project, which has the objective of building a 400 + 400 GeV proton colliding beam facility. The major technical features of the superconducting accelerators with their projected performance are described. Progress made so far, difficulties encountered, and the program until completion in 1986 is briefly reviewed.

  7. Acid, protons and Helicobacter pylori.

    PubMed Central

    Sachs, G.; Meyer-Rosberg, K.; Scott, D. R.; Melchers, K.

    1996-01-01

    The anti-ulcer drugs that act as covalent inhibitors of the gastric acid pump are targeted to the gastric H+/K+ ATPase by virtue of accumulation in acid and conversion to the active sulfenamide. This results in extremely effective inhibition of acid secretion. Appropriate dosage is able to optimize acid control therapy for reflux and peptic ulcer disease as compared to H2 receptor antagonists. However, clinical data on recurrence show that Helicobacter pylori eradication should accompany treatment of the lesion. These drugs have been found to synergize with many antibiotics for eradication. The survival of aerobes depends on their ability to maintain a driving force for protons across their inner membrane, the sum of a pH and potential difference gradient, the protonmotive force (pmf). The transmembrane flux of protons across the F1F0 ATPase, driven by the pmf, is coupled to the synthesis of ATP. The internal pH of H. pylori was measured using the fluorescent dye probe, BCECF, and the membrane potential defined by the uptake of the carbocyanine dye, DiSC3 [5] at different pHs to mimic the gastric environment. The protonmotive force at pH 7.0 was composed of a delta pH of 1.4 (-84mV) and a delta potential difference of -131mV, to give a pmf of -215 mV. The effect of variations in external pH on survival of the bacteria in the absence of urea correlated with the effect of external pH on the ability of the bacteria to maintain a pmf. The effect of the addition of 5 mM urea on the pmf was measured at different medium pH values. Urea restored the pmf at pH 3.0 or 3.5, but abolished the pmf at pH 7.0 or higher, due the production of the alkalinizing cation, NH3. Hence H. pylori is an acid-tolerant neutrophile due to urease activity, but urease activity also limits its survival to an acidic environment. These data help explain the occupation of the stomach by the organism and its distribution between fundus and antrum. This distribution and its alteration by proton pump

  8. Mw Dependence of Ionospheric Electron Enhancement Immediately Before Large Earthquakes

    NASA Astrophysics Data System (ADS)

    Heki, K.; He, L.

    2015-12-01

    Ionospheric electrons were reported to have increased ~40 minutes before the 2011 Tohoku-oki (Mw9.0) earthquake, Japan, by observing total electron content (TEC) with GNSS receivers [e.g. Heki and Enomoto, 2013]. They further demonstrated that similar TEC enhancements preceded all the recent earthquakes with Mw of 8.5 or more. Their reality has been repeatedly questioned due mainly to the ambiguity in the derivation of the reference TEC curves from which anomalies are defined [e.g. Masci et al., 2015]. Here we propose a numerical approach, based on Akaike's Information Criterion, to detect positive breaks (sudden increase of TEC rate) in the vertical TEC time series without using reference curves. We demonstrate that such breaks are detected 20-80 minutes before the ten recent large earthquakes with Mw7.8-9.2. The amounts of breaks were found to depend on the background absolute VTEC and Mw, i.e. Break (TECU/h)=4.74Mw+0.13VTEC-39.86, with the standard deviation of ~1.2 TECU/h. We can convert this equation to Mw = (Break-0.13VTEC+39.86)/4.74, which can tell us the Mw of impending earthquakes with uncertainty of ~0.25. The precursor times were longer for larger earthquakes, ranging from ~80 minutes for the largest (2004 Sumatra-Andaman) to ~21 minutes for the smallest (2015 Nepal). The precursors of intraplate earthquakes (e.g. 2012 Indian Ocean) started significantly earlier than interplate ones. We performed the same analyses during periods without earthquakes, and found that positive breaks comparable to that before the 2011 Tohoku-oki earthquake occur once in 20 hours. They originate from small amplitude Large-scale Travelling Ionospheric Disturbances (LSTID), which are excited in the auroral oval and move southward with the velocity of internal gravity waves. This probability is small enough to rule out the fortuity of these breaks, but large enough to make it a challenge to apply preseismic TEC enhancements for short-term earthquake prediction.

  9. Original antigenic sin with human bocaviruses 1-4.

    PubMed

    Li, Xuemeng; Kantola, Kalle; Hedman, Lea; Arku, Benedict; Hedman, Klaus; Söderlund-Venermo, Maria

    2015-10-01

    Human bocavirus (HBoV) 1 is a widespread parvovirus causing acute respiratory disease in young children. In contrast, HBoV2 occurs in the gastrointestinal tract and is potentially associated with gastroenteritis, whilst HBoV3 and -4 infections are less frequent and have not yet been linked with human disease. Due to HBoV1 DNA persistence in the nasopharynx, serology has been advocated as a better alternative for diagnosing acute infections. In constitutionally healthy children, we previously noted that pre-existing HBoV2 immunity in a subsequent HBoV1 infection typically resulted in low or non-existent HBoV1-specific antibody responses. A phenomenon describing such immunological events among related viruses has been known since the 1950s as 'original antigenic sin' (OAS). The aim of this study was to characterize this putative OAS phenomenon in a more controlled setting. Follow-up sera of 10 rabbit pairs, inoculated twice with HBoV1-4 virus-like particles (VLPs) or control antigens, in various combinations, were analysed with HBoV1-4 IgG enzyme immunoassays with and without depletion of heterotypic HBoV antibodies. There were no significant IgG boosts after the second inoculation in either the heterologously or the homologously HBoV-inoculated rabbits, but a clear increase in cross-reactivity was seen with time. We could, however, distinguish a distinct OAS pattern from plain cross-reactivity: half of the heterologously inoculated rabbits showed IgG patterns representative of the OAS hypothesis, in line with our prior results with naturally infected children. HBoVs are the first parvoviruses to show the possible existence of OAS. Our findings provide new information on HBoV1-4 immunity and emphasize the complexity of human bocavirus diagnosis. PMID:26224569

  10. Parity Nonconservation in Proton-Proton and Proton-Water Scattering at 1.5 GeV/c

    DOE R&D Accomplishments Database

    Mischke, R. E.; Bowman, J. D.; Carlini, R.; MacArthur, D.; Nagle, D. E.; Frauenfelder, H.; Harper, R. W.; Yuan, V.; McDonald, A. B.; Talaga, R. L.

    1984-07-01

    Experiments searching for parity nonconservation in the scattering of 1.5 GeV/c (800 MeV) polarized protons from an unpolarized water target and a liquid hydrogen target are described. The intensity of the incident proton beam was measured upstream and downstream of the target by a pair of ionization detectors. The beam helicity was reversed at a 30-Hz rate. Auxiliary detectors monitored beam properties that could give rise to false effects. The result for the longitudinal asymmetry from the water is A{sub L} = (1.7 +- 3.3 +- 1.4) x 10{sup -7}, where the first error is statistical and the second is an estimate of systematic effects. The hydrogen data yield a preliminary result of A{sub L} = (1.0 +- 1.6) x 10{sup -7}. The systematic errors for p-p are expected to be < 1 x 10{sup -7}.

  11. Flash Proton Radiography

    NASA Astrophysics Data System (ADS)

    Merrill, Frank E.

    Protons were first investigated as radiographic probes as high energy proton accelerators became accessible to the scientific community in the 1960s. Like the initial use of X-rays in the 1800s, protons were shown to be a useful tool for studying the contents of opaque materials, but the electromagnetic charge of the protons opened up a new set of interaction processes which complicated their use. These complications in combination with the high expense of generating protons with energies high enough to penetrate typical objects resulted in proton radiography becoming a novelty, demonstrated at accelerator facilities, but not utilized to their full potential until the 1990s at Los Alamos. During this time Los Alamos National Laboratory was investigating a wide range of options, including X-rays and neutrons, as the next generation of probes to be used for thick object flash radiography. During this process it was realized that the charge nature of the protons, which was the source of the initial difficulty with this idea, could be used to recover this technique. By introducing a magnetic imaging lens downstream of the object to be radiographed, the blur resulting from scattering within the object could be focused out of the measurements, dramatically improving the resolution of proton radiography of thick systems. Imaging systems were quickly developed and combined with the temporal structure of a proton beam generated by a linear accelerator, providing a unique flash radiography capability for measurements at Los Alamos National Laboratory. This technique has now been employed at LANSCE for two decades and has been adopted around the world as the premier flash radiography technique for the study of dynamic material properties.

  12. The fragmentation pattern of 1,4-dioxane ion

    NASA Astrophysics Data System (ADS)

    Dunbar, Robert C.; Huang, Fu-Shiuan; Klippenstein, Stephen J.

    1993-09-01

    Fragmentation of 1,4-dioxane ions at low internal energies was studied by photodissociation in the ion cyclotron resonance (ICR) ion trap. Branching ratios, rate--energy curves and kinetic parameters were assigned for the m/z 58, 57 and 45 fragment ions. M/z 58 is formed through a slightly tight rate-limiting transition state (E0 = 1.46 eV, [Delta]S+1000K = -1.4 e.u.) which probably corresponds to rupture of the dioxane ring. M/z 45 is formed through a tight transition state (E0 = 1.42 eV, [Delta]S++1000K = -10.9 eV) which presumably reflects a cyclic rearrangement pathway. The kinetic data for formation of 57 are almost equally well fitted by assuming competitive (RRKM) fragmentation from the parent ion, or assuming sequential fragmentation through an intermediate 58 ion. If the mechanism is solely competitive, the transition state is extraordinary loose (E0 = 1.87 eV, [Delta]S++1000K = 14.8 e.u.) which would be very surprising for this rearrangement dissociation. Accordingly we lean toward a sequential dissociation mechanism leading to the 57 product, and suggest further experimental testing of this possibility via structural studies of the 57 fragment.

  13. Reactivity initiated accident test series Test RIA 1-4

    SciTech Connect

    Martinson, Z.R.; El-Genk, M.S.; Fukuda, S.K.; LaPointe, R.E.; Osetek, D.J.

    1980-05-01

    The Reactivity Initiated Accident (RIA) Test RIA 1-4, the first 9-rod fuel rod bundle RIA Test to be performed at BWR hot startup conditions, was completed on April 16, 1980. The test was performed in the Power Burst Facility (PBF). Objective for Test RIA 1-4 was to provide information regarding loss-of-coolable fuel rod geometry following a RIA event for a peak fuel enthalpy equivalent to the present licensing criteria of 280 cal/g. The most severe RIA is the postulated Boiling Water Reactor (BWR) control rod drop during reactor startup. Therefore the test was conducted at BWR hot startup coolant conditions (538 K, 6.45 MPa, 0.8 1/sec). The test sequence began with steady power operation to condition the fuel, establish a short-lived fission product inventory, and calibrate the calorimetric measurements and core power chambers, neutron flux and gamma flux detectors. The test train was removed from the in-pile tube (IPT) to replace one of the fuel rods with a nominally identical irradiated rod and twelve flux wire monitors. A 2.8 ms period power burst was then performed. Coolant flow measurements were made before and after the power burst to characterize the flow blockage that occurred as a result of fuel rod failure.

  14. Are protons nonidentical fermions?

    SciTech Connect

    Mart, T.

    2014-09-25

    We briefly review the progress of our investigation on the electric (charge) radius of the proton. In order to explain the recently measured proton radius, which is significantly smaller than the standard CODATA value, we assume that the real protons radii are not identical, they are randomly distributed in a certain range. To obtain the measured radius we average the radii and fit both the mean radius and the range. By using an averaged dipole form factor we obtain the charge radius r{sub E} = 0.8333 fm, in accordance with the recent measurement of the Lamb shift in muonic hydrogen.

  15. Proton and electron mean free paths: The Palmer consensus revisited

    NASA Technical Reports Server (NTRS)

    Bieber, John W.; Matthaeus, William H.; Smith, Charles W.; Wanner, Wolfgang; Kallenrode, May-Britt; Wibberenz, Gerd

    1994-01-01

    We present experimental and theoretical evidence suggesting that the mean free path of cosmic-ray electrons and protons may be fundamentally different at low to intermediate (less than 50 MV) rigidities. The experimental evidence is from Helios observations of solar energetic particles, which show that the mean free path of 1.4 MV electrons is often similar to that of 187 MV protons, even though proton mean free paths continue to decrease comparatively rapidly with decreasing rigidty down to the lowest channels (about 100 MV) observed. The theoretical evidence is from computations of particle scattering in dynamical magnetic turbulence, which predict that electrons will have a larger mean free path than protons of the same rigidity. In the light of these new results, 'consensus' ideas about cosmic-ray mean free paths may require drastic revision.

  16. Effect of PEG modification on subtilisin Carlsberg activity, enantioselectivity, and structural dynamics in 1,4-dioxane.

    PubMed

    Castillo, Betzaida; Solá, Ricardo J; Ferrer, Amaris; Barletta, Gabriel; Griebenow, Kai

    2008-01-01

    The employment of enzymes as catalysts within organic media has traditionally been hampered by the reduced enzymatic activities when compared to catalysis in aqueous solution. Although several complementary hypotheses have provided mechanistic insights into the causes of diminished activity, further development of biocatalysts would greatly benefit from effective chemical strategies (e.g., PEGylation) to ameliorate this event. Herein we explore the effects of altering the solvent composition from aqueous buffer to 1,4-dioxane on structural, dynamical, and catalytic properties of the model enzyme subtilisin Carlsberg (SBc). Furthermore, we also investigate the effects of dissolving the enzyme in 1,4-dioxane through chemical modification with poly(ethylene)-glycol (PEG, M(W) = 20 kDa) on these enzyme properties. In 1,4-dioxane a 10(4)-fold decrease in the enzyme's catalytic activity was observed for the hydrolysis reaction of vinyl butyrate with D(2)O and a 50% decrease in enzyme structural dynamics as evidenced by reduced amide H/D exchange kinetics occurred. Attaching increasing amounts of PEG to the enzyme reversed some of the activity loss. Evaluation of the structural dynamic behavior of the PEGylated enzyme within the organic solvent revealed an increase in structural dynamics at increased PEGylation. Correlation analysis between the catalytic and structural dynamic parameters revealed that the enzyme's catalytic activity and enantioselectivity depended on the changes in protein structural dynamics within 1,4-dioxane. These results demonstrate the importance of protein structural dynamics towards regulating the catalytic behavior of enzymes within organic media. PMID:17546684

  17. THEORY OF PROTON EMITTERS

    SciTech Connect

    P. TALOU

    2000-08-01

    Modern theoretical methods used to interpret recent experimental data on ground-state proton emission near the proton drip line are reviewed. Most of them are stationary and are aimed to compute proton decay widths {Gamma}{sub p} only. Comparison is made between these approaches before being compared to experimental data. Our time-dependent approach based on the numerical solution of the time-dependent Schroedinger equation (TDSE) for initial quasi-stationary single-proton states is then introduced. It is shown that much deeper insights into the physics of this clean multidimensional quantum tunneling effect can be accessed, and that in addition to {Gamma}{sub p}, other physical quantities could be tested experimentally, offering new stringent tests on nuclear physics models away from the valley of {beta}-stability. Finally, the necessity of using the TDSE approach in more complex, dynamical, problems is demonstrated.

  18. The Proton Radius Puzzle

    NASA Astrophysics Data System (ADS)

    Downie, E. J.

    2016-03-01

    The proton radius puzzle is the difference between the proton radius as measured with electron scattering and in the excitation spectrum of atomic hydrogen, and that measured with muonic hydrogen spectroscopy. Since the inception of the proton radius puzzle in 2010 by the measurement of Pohl et al.[1], many possible resolutions to the puzzle have been postulated, but, to date, none has been generally accepted. New data are therefore necessary to resolve the issue. We briefly review the puzzle, the proposed solutions, and the new electron scattering and spectroscopy experiments planned and underway. We then introduce the MUSE experiment, which seeks to resolve the puzzle by simultaneously measuring elastic electron and muon scattering on the proton, in both charge states, thereby providing new information to the puzzle. MUSE addresses issues of two-photon effects, lepton universality and, possibly, new physics, while providing simultaneous form factor, and therefore radius, measurements with both muons and electrons.

  19. Apparatus for proton radiography

    DOEpatents

    Martin, Ronald L.

    1976-01-01

    An apparatus for effecting diagnostic proton radiography of patients in hospitals comprises a source of negative hydrogen ions, a synchrotron for accelerating the negative hydrogen ions to a predetermined energy, a plurality of stations for stripping extraction of a radiography beam of protons, means for sweeping the extracted beam to cover a target, and means for measuring the residual range, residual energy, or percentage transmission of protons that pass through the target. The combination of information identifying the position of the beam with information about particles traversing the subject and the back absorber is performed with the aid of a computer to provide a proton radiograph of the subject. In an alternate embodiment of the invention, a back absorber comprises a plurality of scintillators which are coupled to detectors.

  20. Proton channel models

    PubMed Central

    Pupo, Amaury; Baez-Nieto, David; Martínez, Agustín; Latorre, Ramón; González, Carlos

    2014-01-01

    Voltage-gated proton channels are integral membrane proteins with the capacity to permeate elementary particles in a voltage and pH dependent manner. These proteins have been found in several species and are involved in various physiological processes. Although their primary topology is known, lack of details regarding their structures in the open conformation has limited analyses toward a deeper understanding of the molecular determinants of their function and regulation. Consequently, the function-structure relationships have been inferred based on homology models. In the present work, we review the existing proton channel models, their assumptions, predictions and the experimental facts that support them. Modeling proton channels is not a trivial task due to the lack of a close homolog template. Hence, there are important differences between published models. This work attempts to critically review existing proton channel models toward the aim of contributing to a better understanding of the structural features of these proteins. PMID:24755912

  1. [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)].

    PubMed

    Dematteis, Maurice; Pennel, Lucie; Mallaret, Michel

    2012-05-01

    Gamma-hydroxybutyric acid (GHB) is an old anaesthetic drug which was misused in the 80-90's as an anabolic agent (bodybuilding), recreational drug (drunkenness, euphoric, disinhibiting and aphrodisiac effects) and as a date rape drug (disinhibiting, hypnotic and amnesic effects). Its use in the general population is low, and mainly concerns gay population in nightclubs and young people in parties. The intoxications, above all with alcohol combination, can be severe, with coma and breathing depression, or even fatal. Chronic use leads to psychic and physical dependence; withdrawal syndrome can be severe, with agitation and delirium. In 1999, GHB classification as a narcotic resulted in the increased use of GHB prodrugs gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), which were easily commercially available as solvent and cleaning products. Like GHB, they have a narrow window of use, and share similar toxicity. Their increased cases of recreational use and of severe drug intoxication, abuse and dependence, led the French Ministry of Health in 2011 to prohibit their sale and transfer to the public. PMID:22730800

  2. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol.

    PubMed Central

    Andersen, B; Rassov, A; Westergaard, N; Lundgren, K

    1999-01-01

    1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) was identified previously as a potent inhibitor of both the phosphorylated and non-phosphorylated forms of glycogen phosphorylase (EC 2.4.1.1). In the present study, the effects of DAB were investigated in primary cultured rat hepatocytes. The transport of DAB into hepatocytes was dependent on time and DAB concentration. The rate of DAB transport was 192 pmol/min per mg of protein per mM DAB(medium-concentration). In hepatocytes, DAB inhibited basal and glucagon-stimulated glycogenolysis with IC(50) values of 1.0+/-0.3 and 1.1+/-0.2 microM, respectively. The primary inhibitory effect of DAB on glycogenolysis was shown to be due to inhibition of glycogen phosphorylase but, at higher concentrations of DAB, inhibition of the debranching enzyme (4-alpha-glucanotransferase, EC 2.4.1.25) may have an effect. No effects on glycogen synthesis were observed, demonstrating that glycogen recycling does not occur in cultured hepatocytes under the conditions tested. Furthermore, DAB had no effects on phosphorylase kinase, the enzyme responsible for phosphorylation and thereby activation of glycogen phosphorylase, or on protein phosphatase 1, the enzyme responsible for inactivation of glycogen phosphorylase through dephosphorylation. PMID:10477265

  3. Powder metallurgy titanium 6A1-4V plate

    SciTech Connect

    Geisendorfer, R.F.

    1980-01-01

    A powder metallurgical approach has been combined with controlled mill processing to produce a highly uniform plate material suitable for structural applications. Prealloyed ELI Titanium 6A1-4V powder produced by the rotating electrode process was consolidated into billet by hot isostatic pressing. The resulting billet of uniform composition and random texture was then hot cross-rolled to 3 cm thick plate. Following rolling, the plate was given a beta annealing heat treatment to maximize damage tolerance. The plate was characterized with respect to metallurgical structure, composition, texture, and room temperature mechanical properties. The results of the study show that a powder metallurgy titanium mill product possessing uniform macro- and microstructure is technically feasible and exhibits tensile and fatigue properties equivalent to those of conventionally produced ingot-source wrought plate.

  4. 1.4 GHz continuum sources in the Cancer cluster

    NASA Technical Reports Server (NTRS)

    Salpeter, E. E.; Dickey, J. M.

    1987-01-01

    Results of 1.4-GHz continuum observations are presented for 11 VLA fields, using the D-configuration, which contain the A group of the Cnc cluster (CC). Sixteen Zwicky spiral galaxies in the CC were detected, but no ellipticals, confirming the finding that spiral galaxies with close companions tend to have enhanced radio emission. Over 200 continuum sources beyond the CC are tabulated. The spectral index (relative to 610 MHz) is given for many of the sources, including some of the Zwicky galaxies. There is a suggestion for a nonuniform number surface-density distribution of the sources, not correlated with the CC. Possible predictions of such nonuniformities, from assumptions on 'super-superclusters', are discussed.

  5. 1.4GHz Survey of Fossil Groups

    NASA Astrophysics Data System (ADS)

    Hartwick, Victoria; Wilcots, E.; Hess, K. M.

    2010-01-01

    Fossil groups, luminous, isolated elliptical galaxies with extended x-ray halos, represent the remnants of galactic cannibalism within galaxy groups. Current research has concentrated primarily on visible and x-ray observations. Here, we report the results of a preliminary survey of 34 fossil groups observed at 1.4Ghz using the VLA. We detect radio sources in many of the groups. Using radio emission as a tracer for nuclear activity, we estimate the frequency of past and current AGN activity in fossil groups and extract information about the age and evolutionary history of the fossil groups. Further observations at multiple radio frequencies may then provide information about the role of minor mergers and AGN as sources of heat in the IGM and as remedies to the cooling flow problem.

  6. 1,4-diphenylbutadiyne as a potential tritium getter

    SciTech Connect

    Miller, H.H.; Bissell, E.E.; Tsugawa, R.T.; Souers, P.C.

    1980-10-01

    Research on the acetylene compound 1,4-diphenylbutadiyne is an effort to develop an air-operative tritium gas scavenger. T/sub 2/ adds to the acetylene bond of the organic in the presence of a metal catalyst. The catalyst also stimulates the oxidation reaction as well. The butadiyne compound has shown good reaction efficiency at 300 ppM T/sub 2/ in static dry air. At this concentration 75% of the scavenged tritium was in the organic. This work has expanded to the investigation of liquid acetylenes, metal acetylene complexes, organometallics and acetylene based alcohols. The best of these compounds has gettered 100% of 10 to 500 ppM T/sub 2/ for both static and dynamic air flow conditions.

  7. Inositol 1,4,5-trisphosphate induced calcium waves

    NASA Astrophysics Data System (ADS)

    Falcke, M.

    Traveling waves of high concentration of Ca2+ are observed in many different cells and have attracted great interest in experimental and theoretical biological research in recent years. They are created by the nonlinear dynamics of the release and uptake of Ca2+ by intracellular Ca2+ stores like the endoplasmatic or sarcoplasmatic reticulum. Their characteristics depend on other cellular organelles and components like mitochondria and Ca2+ buffers too. Here, we present some mathematical models and results of recent research on intracellular Ca2+ waves generated by the inositol 1,4,5-trisphosphate receptor channel including the modeling of Calcium induced Calcium release, buffer dynamics, impact of mitochondria on wave formation and the effect of the spatial discreteness of the channels releasing Ca2+. Modeling of the communication of Ca2+ waves to adjacent cells through gap junctions concludes this report.

  8. Proton beam therapy facility

    SciTech Connect

    Not Available

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  9. Luminosity-independent measurement of the proton-proton total cross section at √s=8 TeV.

    PubMed

    Antchev, G; Aspell, P; Atanassov, I; Avati, V; Baechler, J; Berardi, V; Berretti, M; Bossini, E; Bottigli, U; Bozzo, M; Brücken, E; Buzzo, A; Cafagna, F S; Calicchio, M; Catanesi, M G; Covault, C; Csanád, M; Csörgő, T; Deile, M; Doubek, M; Eggert, K; Eremin, V; Ferretti, R; Ferro, F; Fiergolski, A; Garcia, F; Giani, S; Greco, V; Grzanka, L; Heino, J; Hilden, T; Intonti, R A; Kašpar, J; Kopal, J; Kundrát, V; Kurvinen, K; Lami, S; Latino, G; Lauhakangas, R; Leszko, T; Lippmaa, E; Lokajíček, M; Lo Vetere, M; Lucas Rodríguez, F; Macrí, M; Mäki, T; Mercadante, A; Minafra, N; Minutoli, S; Nemes, F; Niewiadomski, H; Oliveri, E; Oljemark, F; Orava, R; Oriunno, M; Österberg, K; Palazzi, P; Procházka, J; Quinto, M; Radermacher, E; Radicioni, E; Ravotti, F; Robutti, E; Ropelewski, L; Ruggiero, G; Saarikko, H; Santroni, A; Scribano, A; Smajek, J; Snoeys, W; Sziklai, J; Taylor, C; Turini, N; Vacek, V; Vítek, M; Welti, J; Whitmore, J; Wyszkowski, P

    2013-07-01

    The TOTEM collaboration has measured the proton-proton total cross section at √s=8 TeV using a luminosity-independent method. In LHC fills with dedicated beam optics, the Roman pots have been inserted very close to the beam allowing the detection of ~90% of the nuclear elastic scattering events. Simultaneously the inelastic scattering rate has been measured by the T1 and T2 telescopes. By applying the optical theorem, the total proton-proton cross section of (101.7±2.9) mb has been determined, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: σ(el)=(27.1±1.4) mb; σ(inel)=(74.7±1.7) mb. PMID:23862993

  10. Luminosity-Independent Measurement of the Proton-Proton Total Cross Section at s=8TeV

    NASA Astrophysics Data System (ADS)

    Antchev, G.; Aspell, P.; Atanassov, I.; Avati, V.; Baechler, J.; Berardi, V.; Berretti, M.; Bossini, E.; Bottigli, U.; Bozzo, M.; Brücken, E.; Buzzo, A.; Cafagna, F. S.; Calicchio, M.; Catanesi, M. G.; Covault, C.; Csanád, M.; Csörgő, T.; Deile, M.; Doubek, M.; Eggert, K.; Eremin, V.; Ferretti, R.; Ferro, F.; Fiergolski, A.; Garcia, F.; Giani, S.; Greco, V.; Grzanka, L.; Heino, J.; Hilden, T.; Intonti, R. A.; Kašpar, J.; Kopal, J.; Kundrát, V.; Kurvinen, K.; Lami, S.; Latino, G.; Lauhakangas, R.; Leszko, T.; Lippmaa, E.; Lokajíček, M.; Lo Vetere, M.; Lucas Rodríguez, F.; Macrí, M.; Mäki, T.; Mercadante, A.; Minafra, N.; Minutoli, S.; Nemes, F.; Niewiadomski, H.; Oliveri, E.; Oljemark, F.; Orava, R.; Oriunno, M.; Österberg, K.; Palazzi, P.; Procházka, J.; Quinto, M.; Radermacher, E.; Radicioni, E.; Ravotti, F.; Robutti, E.; Ropelewski, L.; Ruggiero, G.; Saarikko, H.; Santroni, A.; Scribano, A.; Smajek, J.; Snoeys, W.; Sziklai, J.; Taylor, C.; Turini, N.; Vacek, V.; Vítek, M.; Welti, J.; Whitmore, J.; Wyszkowski, P.

    2013-07-01

    The TOTEM collaboration has measured the proton-proton total cross section at s=8TeV using a luminosity-independent method. In LHC fills with dedicated beam optics, the Roman pots have been inserted very close to the beam allowing the detection of ˜90% of the nuclear elastic scattering events. Simultaneously the inelastic scattering rate has been measured by the T1 and T2 telescopes. By applying the optical theorem, the total proton-proton cross section of (101.7±2.9)mb has been determined, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: σel=(27.1±1.4)mb; σinel=(74.7±1.7)mb.

  11. 350 MW(t) MHTGR preassembly and modularization

    SciTech Connect

    Venkatesh, M.C. ); Jones, G. ); Dilling, D.A. ); Parker, W.J. )

    1991-05-01

    The Modular High Temperature Gas Cooled Reactor (MHTGR) provides a safe and economical nuclear power option for the world's electrical generation needs by the turn of the century. The proposed MHTGR plant is composed of four 350 MW(t) prismatic core reactor modules, coupled to a 2(2 {times} 1) turbine generator producing a net plant electrical output of 538 MW(e). Each of the four reactor module is located in a below-ground level concrete silo, and consists of a reactor vessel and a steam generator vessel interconnected by a cross duct vessel. The modules, along with the service buildings, are contained within a Nuclear Island (NI). The turbine generators and power generation facilities are in the non-nuclear Energy Conversion Area (ECA). The MHTGR design reduces cost and improves schedule by maximizing shop fabrication, minimizing field fit up of the Reactor Internals components and modularizing the NI ECA facilities. 3 refs., 6 figs., 2 tabs.

  12. Performance of a 150-MW S-band klystron

    SciTech Connect

    Sprehn, D.; Phillips, R.M.; Caryotakis, G.

    1994-09-01

    As part of an international collaboration, the Stanford Linear Accelerator Center (SLAC) klystron group has designed, fabricated, and tested a 60-Hz, 3-{mu}s, 150-MW S-band klystron built for Deutsches Elektronen Synchrotron (DESY). A test diode with a 535-kV, 700-A electron beam was constructed to verify the gun operation. The first klystron was built and successfully met design specifications. The 375-MW electron beam represents a new record for SLAC accelerator klystrons in terms of voltage, current, energy, and ruggedness of design. The rf output power is a 150% increase over the S-band tubes currently used in the two-mile-long linear accelerator at SLAC. This paper discusses design issues and experimental results of the diode and klystron.

  13. German paper mill served by 40 MW cogen project

    SciTech Connect

    Mullins, P.

    1994-10-01

    A cogeneration plant to produce 40 MW of electricity and 120 MW of thermal energy is currently coming on stream at Eilenburg, Germany. It is to serve a paper mill recently built by Sachen Papier Eilenburg GmbH. The mill is designed to manufacture 280,000 t/yr of recycled fiber-based newsprint. The power supply will be connected to the local grid so that differences between demand and production can be equalized. The plant will operate at around 80% efficiency for 24 h/day, 365 days a year: so a provision is made for individual parts to operate independently when other areas are shut down for maintenance. 3 figs.

  14. PROTON MICROSCOPY AT FAIR

    SciTech Connect

    Merrill, F. E.; Mariam, F. G.; Golubev, A. A.; Turtikov, V. I.; Varentsov, D.

    2009-12-28

    Proton radiography was invented in the 1990's at Los Alamos National Laboratory (LANL) as a diagnostic to study dynamic material properties under extreme pressures, strain and strain rate. Since this time hundreds of dynamic proton radiography experiments have been performed at LANL and a facility has been commissioned at the Institute for Theoretical and Experimental Physics (ITEP) in Russia for similar applications in dynamic material studies. Recently an international effort has investigated a new proton radiography capability for the study of dynamic material properties at the Facility for Anti-proton and Ion Research (FAIR) located in Darmstadt, Germany. This new Proton microscope for FAIR(PRIOR) will provide radiographic imaging of dynamic systems with unprecedented spatial, temporal and density resolution, resulting in a window for understanding dynamic material properties at new length scales. It is also proposed to install the PRIOR system at the GSI Helmholtzzentrum fuer Schwerionenforschung before installation at FAIR for dynamic experiments with different drivers including high explosives, pulsed power and lasers. The design of the proton microscope and expected radiographic performance is presented.

  15. Finite element analysis of the 2240 MW HTGR PCRV

    SciTech Connect

    Fugelso, L.E.

    1986-04-01

    Three-dimensional finite element calculations for the response of the prestressed concrete reactor vessel for the 2240 MW HTGR which evaluated the stress distributions and concentrations were accomplished. Constitutive equations utilized in this evaluation were linear elastic, Von Mises elastic-plastic and the empirical Kotsovos-Newman concrete fit with and without steel reinforcing. Ultimate values of the internal pressures without initial prestress were obtained. Also stresses in the annular concrete retaining cover over the stream generator were evaluated.

  16. Initial operation of an x-band 100 MW gryoklystron

    SciTech Connect

    Lawson, W.; Cheng, J.; Calame, J.P.; Hogan, B.; Castle, M.; Saraph, G.P.; Granatstein, V.L.

    1995-12-31

    In this paper the authors describe the experimental test bed and preliminary cold-testing of the coaxial gyrotron experiment which is designed to produce over 100 MW at 8.57 GHz. Theoretical efficiency estimates exceed 40%. The nominal beam voltage is 500 kV and the single-anode Magnetron Injection Gun can operate with a beam current up to 720 A. Construction of the new facility is nearing completion.

  17. 50 MW, 35 GHz Gyroklystron Design for Advanced Accelerators

    NASA Astrophysics Data System (ADS)

    Arjona, Melany; Lawson, Wes

    1999-11-01

    We present the design results for a 50 MW, 35 GHz, 4-cavity gyroklystron system. We present both the design of the double-anode magnetron injection gun and the microwave circuit. The gun produces a 500 kV, 300 A beam with a velocity ratio of 1.5 and an axial spread of about 5The interaction efficiency is near 4050 dB. Details of the simulations, including sensitivity studies, will be given in the talk.

  18. SPALLATION NEUTRON SOURCE OPERATIONAL EXPERIENCE AT 1 MW

    SciTech Connect

    Galambos, John D

    2011-01-01

    The Spallation Neutron Source (SNS) has been operating at the MW level for about one year. Experience in beam loss control and machine activation at this power level is presented. Also experience with machine protection systems is reviewed, which is critical at this power level. One of the most challenging operational aspects of high power operation has been attaining high availability, which is also discussed

  19. Low Beam Voltage, 10 MW, L-Band Cluster Klystron

    SciTech Connect

    Teryaev, V.; Yakovlev, V.P.; Kazakov, S.; Hirshfield, J.L.; /Yale U. /Omega-P, New Haven

    2009-05-01

    Conceptual design of a multi-beam klystron (MBK) for possible ILC and Project X applications is presented. The chief distinction between this MBK design and existing 10-MW MBK's is the low operating voltage of 60 kV. There are at least four compelling reasons that justify development at this time of a low-voltage MBK, namely (1) no pulse transformer; (2) no oil tank for high-voltage components and for the tube socket; (3) no high-voltage cables; and (4) modulator would be a compact 60-kV IGBT switching circuit. The proposed klystron consists of four clusters containing six beams each. The tube has common input and output cavities for all 24 beams, and individual gain cavities for each cluster. A closely related optional configuration, also for a 10 MW tube, would involve four totally independent cavity clusters with four independent input cavities and four 2.5 MW output ports, all within a common magnetic circuit. This option has appeal because the output waveguides would not require a controlled atmosphere, and because it would be easier to achieve phase and amplitude stability as required in individual SC accelerator cavities.

  20. LBNF 1.2 MW TARGET: CONCEPTUAL DESIGN & FABRICATION

    SciTech Connect

    Crowley, Cory F.; Ammigan, K.; Anderson, K.; Hartsell, B.; Hurh, P.; Hylen, J.; Zwaska, R.

    2015-06-29

    Fermilab’s Long-Baseline Neutrino Facility (LBNF) will utilize a modified design based on the NuMI low energy target that is reconfigured to accommodate beam operation at 1.2 MW. Achieving this power with a graphite target material and ancillary systems originally rated for 400 kW requires several design changes and R&D efforts related to material bonding and electrical isolation. Target cooling, structural design, and fabrication techniques must address higher stresses and heat loads that will be present during 1.2 MW operation, as the assembly will be subject to cyclic loads and thermal expansion. Mitigations must be balanced against compromises in neutrino yield. Beam monitoring and subsystem instrumentation will be updated and added to ensure confidence in target positioning and monitoring. Remote connection to the target hall support structure must provide for the eventual upgrade to a 2.4 MW target design, without producing excessive radioactive waste or unreasonable exposure to technicians during reconfiguration. Current designs and assembly layouts will be presented, in addition to current findings on processes and possibilities for prototype and final assembly fabrication.

  1. Synthesis and Photophysical and Electroluminescent Properties of Poly(1,4-phenylene–ethynylene)-alt-poly(1,4-phenylene–vinylene)s with Various Dissymmetric Substitution of Alkoxy Side Chains

    PubMed Central

    2016-01-01

    The synthesis and characterization of a set of conjugated polymers, poly(1,4-phenylene–ethynylene)-alt-poly(1,4-phenylene–vinylene)s (PPE–PPVs), with a dissymmetrical configuration (partial or total) of alkoxy side chains is reported. Five new polymers bearing octyloxy and/or octadecyloxy side chains at the phenylene–ethynylene and phenylene–vinylene segments, respectively, were obtained. Two symmetrical substituted polymers were used for comparison. Polymers with weight-average molecular weight, Mw, up to 430 000 g/mol and degree of polymerization between 17 and 322 were obtained by a Horner–Wadsworth–Emmons olefination polycondensation reaction of the respective luminophoric dialdehydes and bisphosphonates. As expected, identical conjugated backbones in all polymers results in very similar photophysical response in dilute solution, with high fluorescence quantum yields between 50% and 80%. In contrast, the thin film properties are dependent on the combinatorial effects of side chain configuration, molecular weight, and film thickness parameters, which are the basis of the resulting comparison and discussion. PMID:26877550

  2. The Solar Electron And Proton Telescope (sept)

    NASA Astrophysics Data System (ADS)

    Falkner, P.; Johlander, B.; Mueller-Mellin, R.; Sanderson, T.; Habinc, S.

    The Solar Electron and Proton Telescope consists of two dual double-ended mag- net/foil particle telescopes which cleanly separate and measure electrons in the energy range from 20 - 400 keV and protons from 20 - 7000 keV. The instrument utilizes an ASIC-PDFE (Particle Detection Front End), which provides low noise charge sensi- tive pre-amplifier, filters, pulse shaper, 8-bit ADC and anti-coincidence electronics for a single solid-state detector. The counts are accumulated in 256 linear bins on a radia- tion hardened SRAM under control of an FPGA and read out once every minute by the supervising DPU. The FPGA provides the possibility of quasi-logarithmic binning be- fore transferring the data to the main DPU. A simple ramp pulser provides electronic in-flight instrument calibration and testing. The complete instrument with 4 complete channels has a mass of 500 g and consumes 500 mW of power. The maximum count rate is 250 ksamples per second per channel. The instrument is to be flown on the Solar Terrestrial Relations Observatory (STEREO) mission with intended launch in 2005. The talk describes the technical implementation of the instrument.

  3. Exotic Protonated Species Produced by UV-Induced Photofragmentation of a Protonated Dimer: Metastable Protonated Cinchonidine.

    PubMed

    Alata, Ivan; Scuderi, Debora; Lepere, Valeria; Steinmetz, Vincent; Gobert, Fabrice; Thiao-Layel, Loïc; Le Barbu-Debus, Katia; Zehnacker-Rentien, Anne

    2015-10-01

    A metastable protonated cinchona alkaloid was produced in the gas phase by UV-induced photodissociation (UVPD) of its protonated dimer in a Paul ion trap. The infrared multiple photon dissociation (IRMPD) spectrum of the molecular ion formed by UVPD was obtained and compared to DFT calculations to characterize its structure. The protonation site obtained thereby is not accessible by classical protonation ways. The protonated monomer directly formed in the ESI source or by collision-induced dissociation (CID) of the dimer undergoes protonation at the most basic alkaloid nitrogen. In contrast, protonation occurs at the quinoline aromatic ring nitrogen in the UVPD-formed monomer. PMID:26347997

  4. Commissioning plan for a high-current proton linac

    SciTech Connect

    Chan, K.C.D.; Barber, R.L.; Garnett, R.W.

    1997-09-01

    High-power proton linacs (E>500 MeV) are potentially useful for transmutation applications, such as the production of tritium. In production applications, high availability is essential. Achieving high availability requires an accelerator design that simplifies maintenance and accommodates commissioning procedures designed to minimize tune-up time. These are worthwhile goals for any accelerator, but the very high beam powers (170 MW) and heavy beam loading of the Accelerator Production of Tritium (APT) linac introduce significant new challenges. This paper will describe the commissioning plan, as developed to date.

  5. Atmospheric photochemical degradation of 1,4-unsaturated dicarbonyls

    SciTech Connect

    Liu, X.; Jeffries, H.E.; Sexton, K.G.

    1999-12-01

    To better understand fates of aromatics hydrocarbon species in the atmosphere, the authors have investigated the transformation chemistry of butenedial (CHOCH{double{underscore}bond}CHCHO), 4-oxo-2-pentenal (CH{sub 3}COCH{double{underscore}bond}CHCHO), and 3-hexene-2, 5-dione (CH{sub 3}COCH{double{underscore}bond}CHCOCH{sub 3}). These 1,4-unsaturated dicarbonyls are known to be products of aromatic photochemical oxidation. Both hydroxyl radical (OH) and ozone (O{sub 3}) initiated smog chamber experiments under atmospheric conditions were conducted in the University of North Carolina outdoor smog chamber. Carbonyl intermediates and products were measured using the O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine derivatization method followed by gas chromatography/ion trap mass spectrometry analysis. Carbonyl products detected and identified by comparison with standards in the OH-initiated photooxidation of butenedial include formaldehyde, acrolein, glycolaldehyde, glyoxal, and malonaldehyde (CHOCH{sub 2}CHO). For 4-oxo-2-pentenal, the carbonyl products were formaldehyde, methyl vinyl ketone, glycolaldehyde, hydroxyacetone, glyoxal, methylglyoxal, and malonaldehyde. for 3-hexene-2,5-dione the products were formaldehyde, acetaldehyde, acetone, hydroxyacetone, and methylglyoxal. Carbonyl products detected in the P{sub 3}-initiated experiments with cyclohexane as the OH scavenger were formaldehyde and glyoxal in butenedial; formaldehyde, glyoxal, methyl-glyoxal, and malonaldehyde in 4-oxo-2-pentenal; and formaldehyde and methylglyoxal in 3-hexene-2,5-dione.

  6. Orbital forcing of climate 1.4 billion years ago.

    PubMed

    Zhang, Shuichang; Wang, Xiaomei; Hammarlund, Emma U; Wang, Huajian; Costa, M Mafalda; Bjerrum, Christian J; Connelly, James N; Zhang, Baomin; Bian, Lizeng; Canfield, Donald E

    2015-03-24

    Fluctuating climate is a hallmark of Earth. As one transcends deep into Earth time, however, both the evidence for and the causes of climate change become difficult to establish. We report geochemical and sedimentological evidence for repeated, short-term climate fluctuations from the exceptionally well-preserved ∼1.4-billion-year-old Xiamaling Formation of the North China Craton. We observe two patterns of climate fluctuations: On long time scales, over what amounts to tens of millions of years, sediments of the Xiamaling Formation record changes in geochemistry consistent with long-term changes in the location of the Xiamaling relative to the position of the Intertropical Convergence Zone. On shorter time scales, and within a precisely calibrated stratigraphic framework, cyclicity in sediment geochemical dynamics is consistent with orbital control. In particular, sediment geochemical fluctuations reflect what appear to be orbitally forced changes in wind patterns and ocean circulation as they influenced rates of organic carbon flux, trace metal accumulation, and the source of detrital particles to the sediment. PMID:25775605

  7. Solar wind halo electrons from 1-4 AU

    NASA Technical Reports Server (NTRS)

    Mccomas, D. J.; Bame, S. J.; Feldman, W. C.; Gosling, J. T.; Phillips, J. L.

    1992-01-01

    Observations from the Ulysses solar wind electron spectrometer are used to make a first examination of the evolution of the solar wind suprathermal or halo electron population as a function of heliocentric distance beyond 1 AU. As the core population cools with increasing heliocentric distance, no gap is formed between the core and halo populations. Rather, the halo electrons extend to increasingly lower energies. As predicted previously on theoretical grounds, the ratio of the core electron temperature to the low energy cutoff of the halo population appears to be roughly constant with a value of about 7.5. The total integrated heat flux drops rapidly with increasing heliocentric distance; a best fit power law of R exp -2.36 is found. In addition, it is found that the ratio of the halo to core densities is roughly constant over heliocentric distance with the halo representing 4 percent of the total electron distribution. These results suggest that the halo population may not consist of truly noninteractive test particles over the heliocentric range of 1-4 AU.

  8. Orbital forcing of climate 1.4 billion years ago

    PubMed Central

    Zhang, Shuichang; Wang, Xiaomei; Hammarlund, Emma U.; Wang, Huajian; Costa, M. Mafalda; Bjerrum, Christian J.; Connelly, James N.; Zhang, Baomin; Bian, Lizeng; Canfield, Donald E.

    2015-01-01

    Fluctuating climate is a hallmark of Earth. As one transcends deep into Earth time, however, both the evidence for and the causes of climate change become difficult to establish. We report geochemical and sedimentological evidence for repeated, short-term climate fluctuations from the exceptionally well-preserved ∼1.4-billion-year-old Xiamaling Formation of the North China Craton. We observe two patterns of climate fluctuations: On long time scales, over what amounts to tens of millions of years, sediments of the Xiamaling Formation record changes in geochemistry consistent with long-term changes in the location of the Xiamaling relative to the position of the Intertropical Convergence Zone. On shorter time scales, and within a precisely calibrated stratigraphic framework, cyclicity in sediment geochemical dynamics is consistent with orbital control. In particular, sediment geochemical fluctuations reflect what appear to be orbitally forced changes in wind patterns and ocean circulation as they influenced rates of organic carbon flux, trace metal accumulation, and the source of detrital particles to the sediment. PMID:25775605

  9. Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors

    PubMed Central

    Fedorenko, Olena A.; Popugaeva, Elena; Enomoto, Masahiro; Stathopulos, Peter B.; Ikura, Mitsuhiko; Bezprozvanny, Ilya

    2014-01-01

    The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca2+-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca2+ events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms of InsP3R function and modulation. Cell biological and biochemical studies lead to identification of a large number of InsP3R-binding proteins. InsP3Rs are involved in the regulation of numerous physiological processes, including learning and memory, proliferation, differentiation, development and cell death. Malfunction of InsP3R1 play a role in a number of neurodegenerative disorders and other disease states. InsP3Rs represent a potentially valuable drug target for treatment of these disorders and for modulating activity of neurons and other cells. Future studies will provide better understanding of physiological functions of InsP3Rs in health and disease. PMID:24300389

  10. Phytoremediation of 1,4-dioxane-containing recovered groundwater.

    PubMed

    Ferro, Ari M; Kennedy, Jean; LaRue, James C

    2013-01-01

    The results of a pilot-scale phytoremediation study are reported in this paper. Small plots of trees established on a closed municipal waste landfill site were irrigated with recovered groundwater containing 1,4-dioxane (dioxane) and other volatile organic compounds (VOCs). The plots were managed to minimize the leaching of irrigation water, and leaching was quantified by the use of bromide tracer. Results indicated that the dioxane (2.5 microg/L) was effectively removed, probably via phytovolatilization, and that a full-scale phytoremediation system could be used. A system is now in place at the site in which the recovered groundwater can be treated using two different approaches. A physical treatment system (PTS) will be used during the winter months, and a 12 ha phytoremediation system (stands of coniferous trees) will be used during the growing season. The PTS removes VOCs using an air-stripper, and destroys dioxane using a photo-catalytic oxidation process. Treated water will be routed to the local sewer system. The phytoremediation system, located on the landfill, will be irrigated with effluent from the PTS air-stripper containing dioxane. Seasonal use of the phytoremediation system will reduce reliance on the photo-catalytic oxidation process that is extremely energy consumptive and expensive to operate. PMID:23819285

  11. Active flow control on a 1:4 car model

    NASA Astrophysics Data System (ADS)

    Heinemann, Till; Springer, Matthias; Lienhart, Hermann; Kniesburges, Stefan; Othmer, Carsten; Becker, Stefan

    2014-05-01

    Lift and drag of a passenger car are strongly influenced by the flow field around its rear end. The bluff body geometry produces a detached, transient flow which induces fluctuating forces on the body, affecting the rear axle, which may distress dynamic stability and comfort significantly. The investigations presented here deal with a 1:4 scale model of a simplified test car geometry that produces fluctuating lift and drag due to its strongly rounded rear geometry. To examine the influence of active flow control on this behavior, steady air jets were realized to exhaust from thin slots across the rear in three different configurations. Investigations were performed at and included the capturing of effective integral lift and drag, velocity measurements in the surrounding flow field with Laser Doppler Anemometry, surface pressure measurements and surface oil flow visualization on the rear. The flow field was found to be dominated by two longitudinal vortices, developing from the detachment of the flow at the upper C-pillar positions, and a recirculating, transverse vortex above the rear window. With an air jet emerging from a slot across the surface right below the rear window section, tangentially directed upstream toward the roof section, total lift could be reduced by more than 7 %, with rear axle lift reduction of about 5 % and negligible drag affection (1 %).

  12. Proton re-evaluated

    NASA Astrophysics Data System (ADS)

    Clark, P. S.

    1986-08-01

    The three versions of the Proton booster used to date are presented and connections are made between the Proton and the U.S.S.R.'s lunar program. The question as to whether or not the proton could be manrated is addressed. The original version of the Proton, known as the SL-9 vehicle, consists of the first stage cluster of six engines with a 13-ton second stage. The second version was the SL-12 and the third version was the SL-13. The SL-13 consists of the SL-9 with a new 5.6-ton third stage added. The SL-12, introduced before the SL-13, uses the basic three stages of the SL-13 with a fourth escape stage added. The use of the SL-12 vehicle in two major series of applications satellites put in earth orbit is described. It is noted that if the loss of the Challenger Orbiter results in a major shift in Shuttle payload philosophy, the Proton and other expendable boosters will be called upon to fill the gaps.

  13. High Temperature Protonic Conductors

    NASA Technical Reports Server (NTRS)

    Dynys, Fred; Berger, Marie-Helen; Sayir, Ali

    2007-01-01

    High Temperature Protonic Conductors (HTPC) with the perovskite structure are envisioned for electrochemical membrane applications such as H2 separation, H2 sensors and fuel cells. Successive membrane commercialization is dependent upon addressing issues with H2 permeation rate and environmental stability with CO2 and H2O. HTPC membranes are conventionally fabricated by solid-state sintering. Grain boundaries and the presence of intergranular second phases reduce the proton mobility by orders of magnitude than the bulk crystalline grain. To enhanced protonic mobility, alternative processing routes were evaluated. A laser melt modulation (LMM) process was utilized to fabricate bulk samples, while pulsed laser deposition (PLD) was utilized to fabricate thin film membranes . Sr3Ca(1+x)Nb(2-x)O9 and SrCe(1-x)Y(x)O3 bulk samples were fabricated by LMM. Thin film BaCe(0.85)Y(0.15)O3 membranes were fabricated by PLD on porous substrates. Electron microscopy with chemical mapping was done to characterize the resultant microstructures. High temperature protonic conduction was measured by impedance spectroscopy in wet air or H2 environments. The results demonstrate the advantage of thin film membranes to thick membranes but also reveal the negative impact of defects or nanoscale domains on protonic conductivity.

  14. Proton transfer in organic scaffolds

    NASA Astrophysics Data System (ADS)

    Basak, Dipankar

    This dissertation focuses on the fundamental understanding of the proton transfer process and translating the knowledge into design/development of new organic materials for efficient non-aqueous proton transport. For example, what controls the shuttling of a proton between two basic sites? a) Distance between two groups? or b) the basicity? c) What is the impact of protonation on molecular conformation when the basic sites are attached to rigid scaffolds? For this purpose, we developed several tunable proton sponges and studied proton transfer in these scaffolds theoretically as well as experimentally. Next we moved our attention to understand long-range proton conduction or proton transport. We introduced liquid crystalline (LC) proton conductor based on triphenylene molecule and established that activation energy barrier for proton transport is lower in the LC phase compared to the crystalline phase. Furthermore, we investigated the impact of several critical factors: the choice of the proton transferring groups, mobility of the charge carriers, intrinsic vs. extrinsic charge carrier concentrations and the molecular architectures on long-range proton transport. The outcome of this research will lead to a deeper understanding of non-aqueous proton transfer process and aid the design of next generation proton exchange membrane (PEM) for fuel cell.

  15. All-solid-state proton battery using gel polymer electrolyte

    SciTech Connect

    Mishra, Kuldeep; Pundir, S. S.; Rai, D. K.

    2014-04-24

    A proton conducting gel polymer electrolyte system; PMMA+NH{sub 4}SCN+EC/PC, has been prepared. The highest ionic conductivity obtained from the system is 2.5 × 10−4 S cm{sup −1}. The optimized composition of the gel electrolyte has been used to fabricate a proton battery with Zn/ZnSO{sub 4}⋅7H{sub 2}O anode and MnO{sub 2} cathode. The open circuit voltage of the battery is 1.4 V and the highest energy density is 5.7 W h kg−1 for low current drain.

  16. First observation of two-proton radioactivity in 48Ni

    SciTech Connect

    Pomorski, M.; Pfutzner, M.; Dominik, W.; Grzywacz, Robert Kazimierz; Baumann, T.; Berryman, J. S.; Czyrkowski, H.; Dabrowski, Ryszard; Ginter, T. N.; Johnson, James W; Kaminski, A.; Kuzniak, A.; Larson, N.; Liddick, S. N.; Madurga, M; Mazzocchi, C.; Miernik, K.; Miller, D; Paulauskas, S.; Pereira, J.; Rykaczewski, Krzysztof Piotr; Stolz, A.; Suchyta, S.

    2011-01-01

    The decay of the extremely neutron deficient 48Ni was studied by means of an imaging time projection chamber which allowed the recording of tracks of charged particles. Decays of 6 atoms were observed. Four of them clearly correspond to two-proton radioactivity providing the first direct evidence for this decay mode in 48Ni. Two decays represent -delayed proton emission. The half-life of 48Ni is determined to be T1=2 = 2:1+1:4 0:4 ms.

  17. Synchrotron radiation from protons

    SciTech Connect

    Dutt, S.K.

    1992-12-01

    Synchrotron radiation from protons, though described by the same equations as the radiation from electrons, exhibits a number of interesting features on account of the parameters reached in praxis. In this presentation, we shall point out some of the features relating to (i) normal synchrotron radiation from dipoles in proton machines such as the High Energy Booster and the Superconducting Super Collider; (ii) synchrotron radiation from short dipoles, and its application to light monitors for proton machines, and (iii) synchrotron radiation from undulators in the limit when, the deflection parameter is much smaller than unity. The material for this presentation is taken largely from the work of Hofmann, Coisson, Bossart, and their collaborators, and from a paper by Kim. We shall emphasize the qualitative aspects of synchrotron radiation in the cases mentioned above, making, when possible, simple arguments for estimating the spectral and angular properties of the radiation. Detailed analyses can be found in the literature.

  18. The physics of proton therapy

    NASA Astrophysics Data System (ADS)

    Newhauser, Wayne D.; Zhang, Rui

    2015-04-01

    The physics of proton therapy has advanced considerably since it was proposed in 1946. Today analytical equations and numerical simulation methods are available to predict and characterize many aspects of proton therapy. This article reviews the basic aspects of the physics of proton therapy, including proton interaction mechanisms, proton transport calculations, the determination of dose from therapeutic and stray radiations, and shielding design. The article discusses underlying processes as well as selected practical experimental and theoretical methods. We conclude by briefly speculating on possible future areas of research of relevance to the physics of proton therapy.

  19. The physics of proton therapy

    PubMed Central

    Newhauser, Wayne D; Zhang, Rui

    2015-01-01

    The physics of proton therapy has advanced considerably since it was proposed in 1946. Today analytical equations and numerical simulation methods are available to predict and characterize many aspects of proton therapy. This article reviews the basic aspects of the physics of proton therapy, including proton interaction mechanisms, proton transport calculations, the determination of dose from therapeutic and stray radiations, and shielding design. The article discusses underlying processes as well as selected practical experimental and theoretical methods. We conclude by briefly speculating on possible future areas of research of relevance to the physics of proton therapy. PMID:25803097

  20. INTEGRATED GASIFICATION COMBINED CYCLE PROJECT 2 MW FUEL CELL DEMONSTRATION

    SciTech Connect

    FuelCell Energy

    2005-05-16

    With about 50% of power generation in the United States derived from coal and projections indicating that coal will continue to be the primary fuel for power generation in the next two decades, the Department of Energy (DOE) Clean Coal Technology Demonstration Program (CCTDP) has been conducted since 1985 to develop innovative, environmentally friendly processes for the world energy market place. The 2 MW Fuel Cell Demonstration was part of the Kentucky Pioneer Energy (KPE) Integrated Gasification Combined Cycle (IGCC) project selected by DOE under Round Five of the Clean Coal Technology Demonstration Program. The participant in the CCTDP V Project was Kentucky Pioneer Energy for the IGCC plant. FuelCell Energy, Inc. (FCE), under subcontract to KPE, was responsible for the design, construction and operation of the 2 MW fuel cell power plant. Duke Fluor Daniel provided engineering design and procurement support for the balance-of-plant skids. Colt Engineering Corporation provided engineering design, fabrication and procurement of the syngas processing skids. Jacobs Applied Technology provided the fabrication of the fuel cell module vessels. Wabash River Energy Ltd (WREL) provided the test site. The 2 MW fuel cell power plant utilizes FuelCell Energy's Direct Fuel Cell (DFC) technology, which is based on the internally reforming carbonate fuel cell. This plant is capable of operating on coal-derived syngas as well as natural gas. Prior testing (1992) of a subscale 20 kW carbonate fuel cell stack at the Louisiana Gasification Technology Inc. (LGTI) site using the Dow/Destec gasification plant indicated that operation on coal derived gas provided normal performance and stable operation. Duke Fluor Daniel and FuelCell Energy developed a commercial plant design for the 2 MW fuel cell. The plant was designed to be modular, factory assembled and truck shippable to the site. Five balance-of-plant skids incorporating fuel processing, anode gas oxidation, heat recovery, water

  1. Physics at an upgraded proton driver at Fermilab

    SciTech Connect

    Steve Geer

    2004-07-28

    The accelerator-based particle physics program in the US is entering a period of transition. This is particularly true at Fermilab which for more than two decades has been the home of the Tevatron Proton-Antiproton Collider, the World's highest energy hadron collider. In a few years time the energy frontier will move to the LHC at CERN. Hence, if an accelerator-based program is to survive at Fermilab, it must evolve. Fermilab is fortunate in that, in addition to hosting the Tevatron Collider, the laboratory also hosts the US accelerator-based neutrino program. The recent discovery that neutrino flavors oscillate has opened a new exciting world for us to explore, and has created an opportunity for the Fermilab accelerator complex to continue to address the cutting-edge questions of particle physics beyond the Tevatron Collider era. The presently foreseen neutrino oscillation experiments at Fermilab (MiniBooNE [1] and MINOS [2]) will enable the laboratory to begin contributing to the Global oscillation physics program in the near future, and will help us better understand the basic parameters describing the oscillations. However, this is only a first step. To be able to pin down all of the oscillation parameters, and hopefully make new discoveries along the way, we will need high statistics experiments, which will require a very intense neutrino beam, and one or more very massive detectors. In particular we will require new MW-scale primary proton beams and perhaps ultimately a Neutrino Factory [3]. Plans to upgrade the Fermilab Proton Driver are presently being developed [4]. The upgrade project would replace the Fermilab Booster with a new 8 GeV accelerator with 0.5-2 MW beam power, a factor of 15-60 more than the current Booster. It would also make the modifications needed to the Fermilab Main Injector (MI) to upgrade it to simultaneously provide 120 GeV beams of 2 MW. This would enable a factor of 5-10 increase in neutrino beam intensities at the MI, while also

  2. Proton irradiation and endometriosis

    SciTech Connect

    Wood, D.H.; Yochmowitz, M.G.; Salmon, Y.L.; Eason, R.L.; Boster, R.A.

    1983-08-01

    It was found that female rhesus monkeys given single total-body exposures of protons of varying energies developed endometriosis at a frequency significantly higher than that of nonirradiated animals of the same age. The minimum latency period was determined to be 7 years after the proton exposure. The doses and energies of the radiation received by the experimental animals were within the range that could be received by an aircrew member in near-earth orbit during a random solar flare event. It is concluded that endometriosis should be a consideration in assessing the risk of delayed radiation effects in female crew members. 15 references.

  3. New 200 MW class 501G combustion turbine

    SciTech Connect

    Southall, L.; McQuiggan, G.

    1996-07-01

    The 501G 60-Hz combustion turbine has been developed jointly by Westinghouse Electric Corporation, Mitsubishi Heavy Industries, Ltd., and FiatAvio. It continues a long line of large heavy-duty single-shaft combustion turbines by combining the proven efficient and reliable concepts of the 501F with the latest advances in aero technology via the Westinghouse Alliance with Rolls-Royce. The output of the 501G is over 230 MW with a combined cycle net efficiency of 58 percent. This makes the 501G the largest 60-Hz combustion turbine in the world and also the most efficient.

  4. The SANS facility at the Pitesti 14MW TRIGA reactor

    SciTech Connect

    Ionita, I. Grabcev, B.; Todireanu, S.; Constantin, F.; Shvetsov, V.; Anghel, E.; Popescu, G.; Mincu, M.; Datcu, A.

    2006-12-15

    The SANS facility existing at the Pitesti 14MW TRIGA reactor is presented. The main characteristics and the preliminary evaluation of the installation performances are given. A monochromatic neutron beam with 1.5 A {<=} {lambda} {<=} 5 A is produced by a mechanical velocity selector with helical slots. A fruitful partnership was established between INR Pitesti (Romania) and JINR Dubna (Russia). The first step in this cooperation consists in the manufacturing in Dubna of a battery of gas-filled positional detectors devoted to the SANS instrument.

  5. Component development for X-band above 100 MW

    SciTech Connect

    Fowkes, W.R.; Callin, R.S.; Studzinski, M.

    1991-05-01

    The requirement for some of the components described in this paper began with the Relativistic Klystron program done in collaboration with LLNL and LBL. This effort culminated in a klystron operating at 11.4 GHz delivering 330 MW into a pair of high-gradient accelerating structures. The electron beam for this klystron was formed in a 1 MeV induction linac at a very low duty cycle. The subsequent RF source development work at SLAC for the Next Linear Collider utilized some of these components, and required further and new development of others, work reliably at higher average power. 6 refs., 6 figs., 1 tab.

  6. The 5 MW for solar-chemistry development

    NASA Astrophysics Data System (ADS)

    Holmes, J. T.

    1981-11-01

    The US-DOE, 5MW solar Central Receiver Test Facility (CRTF) operates to develop and proof-test high efficiency solar receivers and collectors (heliostats) for applications such as electricity generation and process heating. The capabilities of CRTF for solar chemical process development studies are described and related to chemical reactant heating rates. A Sun Fuels program is planned to demonstrate a process for upgrading both nonrenewable and renewable feedstocks into conventional fuels. To additionally benefit from the high intensity light source, studies on the direct solar pyrolysis of metal halides and carbonyls to produce high purity, high value metals are recommended.

  7. Proton-Proton Scattering at 105 Mev and 75 Mev

    DOE R&D Accomplishments Database

    Birge, R. W.; Kruse, U. E.; Ramsey, N. F.

    1951-01-31

    The scattering of protons by protons provides an important method for studying the nature of nuclear forces. Recent proton-proton scattering experiments at energies as high as thirty Mev{sup 1} have failed to show any appreciable contribution to the cross section from higher angular momentum states, but it is necessary to bring in tensor forces to explain the magnitude of the observed cross section.

  8. Ruthenium, osmium and rhodium complexes of 1,4-diaryl 1,4-diazabutadiene: radical versus non-radical states.

    PubMed

    Chandra Patra, Sarat; Saha Roy, Amit; Manivannan, Vadivelu; Weyhermüller, Thomas; Ghosh, Prasanta

    2014-09-28

    Ruthenium, osmium and rhodium complexes of 1,4-di(3-nitrophenyl)-1,4-diazabutadiene (LDAB) of types trans-[RuII(LDAB)(PPh3)2Cl2] (1), trans-[OsII(LDAB)(PPh3)2Br2] (2) and trans-[Rh(LDAB)(PPh3)2Cl2] (3) are isolated and characterized by elemental analyses, IR, mass and 1H NMR spectra including the single crystal X-ray structure determination of 1·2toluene. The α-diimine fragment of the LDAB ligand in 1·2toluene is deformed, showing a relatively longer -C=N- bond, 1.320 Å, and a shorter =CH–CH= bond, 1.395 Å. Density functional theory (DFT) calculations on trans-[Ru(LDAB)(PMe3)2Cl2] (1Me) and trans-[Os(LDAB)(PMe3)2Br2] (2Me) with singlet spin states authenticated that the closed shell singlet state (CSS) solutions of 1 and 2 are stable and no perturbation occurs because of the diradical open shell singlet (OSS) state. The EPR spectra of 3 and the Mulliken spin density distribution obtained from the DFT calculation on trans-[Rh(LDAB)(PMe3)2Cl2] (3Me) imply that the ground electronic state of 3 can be defined by the [RhIII(LDAB˙−)(PPh3)2Cl2] (3RhL˙) ↔ [RhII(LDAB)(PPh3)2Cl2] (3Rh˙L) resonating states. In solid, the contribution of 3RhL˙ is higher and the gav is 2.018 with Δg = 0.10, whereas in frozen glasses the contribution of 3Rh˙L is higher and the gav is 2.026 with Δg (frozen glasses) = 0.13. The g parameters of the electrogenerated [1]+ (g1 = 2.456, g2 = 2.128 and g3 = 1.624, Δg = 0.824), [2]+ (g1 = 2.599, g2 = 2.041 and g3 = 1.965, Δg = 0.634), [1]− (g1 = 2.138, g2 = 2.109, g3 = 1.978 and Δg = 0.160) and [2]− (g1 = 2.168, g2 = 2.097, g3 = 1.987 and Δg = 0.181) ions and the spin density distributions obtained from the DFT calculations on [1Me]+, [2Me]+, [1Me]− and [2Me]− reveal that the reversible anodic peaks of 1 and 2 at 0.11 and 0.34 V, referenced versus Fc+/Fc couple, are due to the M(III)/M(II) redox couple, while the reversible cathodic waves at −1.27 V and −0.82 V of 1 and 2 are caused by the LDAB/LDAB˙− redox couple

  9. Theoretical investigations of the reaction between 1,4-dithiane-2,5-diol and azomethine imines: mechanisms and diastereoselectivity.

    PubMed

    Zheng, Linjie; Qiao, Yan; Lu, Mengxue; Chang, Junbiao

    2015-07-21

    In the present study, mechanistic insights into the domino reaction between 1,4-dithiane-2,5-diol and azomethine imines were derived from the computational study with B3LYP and M06-2X functionals. On the whole, the domino process comprises two consecutive reactions: cleavage of 1,4-dithiane-2,5-diol leading to mercaptoacetaldehyde and [3 + 3] cycloaddition of mercaptoacetaldehyde with azomethine imines. The cleavage of 1,4-dithiane-2,5-diol can take place via multiple possible pathways (1A-1E), and pathway 1E in which double-methanol molecules mediate the proton transfer process is the most energetically favorable, with an energy barrier of 19.9 kcal mol(-1). For the [3 + 3] cycloaddition, three possible pathways (2F-2H) were explored. The calculated energy profiles reveal that pathway 2H with activation energies ranging from 6.9 to 10.2 kcal mol(-1) is more energetically favorable than pathways 2F and 2G. Specifically, pathway 2H comprises three reaction steps: deprotonation of mercaptoacetaldehyde by DABCO allows for the formation of the thiol anion, which subsequently launches a nucleophilic attack on azomethine imines followed by intramolecular cyclization resulting in the final products. The calculated results are in agreement with the experimental observations that the reaction can proceed most efficiently in the presence of both DABCO and methanol. Furthermore, the hydrogen bonding interaction is identified to be the main factor determining the observed diastereoselectivity The current systematic theoretical study gives a full scenario of the reaction between 1,4-dithiane-2,5-diol and azomethine imines catalyzed by DABCO, and thus provides some valuable clues for further investigation and development of this kind of important reaction. PMID:26079432

  10. Evidence of 1,4-dioxane attenuation at groundwater sites contaminated with chlorinated solvents and 1,4-dioxane.

    PubMed

    Adamson, David T; Anderson, R Hunter; Mahendra, Shaily; Newell, Charles J

    2015-06-01

    There is a critical need to develop appropriate management strategies for 1,4-dioxane (dioxane) due to its widespread occurrence and perceived recalcitrance at groundwater sites where chlorinated solvents are present. A comprehensive evaluation of California state (GeoTracker) and Air Force monitoring records was used to provide significant evidence of dioxane attenuation at field sites. Temporal changes in the site-wide maximum concentrations were used to estimate source attenuation rates at the GeoTracker sites (median length of monitoring period = 6.8 years). While attenuation could not be established at all sites, statistically significant positive attenuation rates were confirmed at 22 sites. At sites where dioxane and chlorinated solvents were present, the median value of all statistically significant dioxane source attenuation rates (equivalent half-life = 31 months; n = 34) was lower than 1,1,1-trichloroethane (TCA) but similar to 1,1-dichloroethene (1,1-DCE) and trichloroethene (TCE). Dioxane attenuation rates were positively correlated with rates for 1,1-DCE and TCE but not TCA. At this set of sites, there was little evidence that chlorinated solvent remedial efforts (e.g., chemical oxidation, enhanced bioremediation) impacted dioxane attenuation. Attenuation rates based on well-specific records from the Air Force data set confirmed significant dioxane attenuation (131 out of 441 wells) at a similar frequency and extent (median equivalent half-life = 48 months) as observed at the California sites. Linear discriminant analysis established a positive correlation between dioxane attenuation and increasing concentrations of dissolved oxygen, while the same analysis found a negative correlation with metals and CVOC concentrations. The magnitude and prevalence of dioxane attenuation documented here suggest that natural attenuation may be used to manage some but not necessarily all dioxane-impacted sites. PMID:25970261

  11. Progresses in proton radioactivity studies

    NASA Astrophysics Data System (ADS)

    Ferreira, L. S.; Maglione, E.

    2016-07-01

    In the present talk, we will discuss recent progresses in the theoretical study of proton radioactivity and their impact on the present understanding of nuclear structure at the extremes of proton stability.

  12. Proton Nucleus Elastic Scattering Data.

    1993-08-18

    Version 00 The Proton Nucleus Elastic Scattering Data file PNESD contains the numerical data and the related bibliography for the differential elastic cross sections, polarization and integral nonelastic cross sections for elastic proton-nucleus scattering.

  13. Three new defined proton affinities for polybasic molecules in the gas-phase: Proton microaffinity, proton macroaffinity and proton overallaffinity

    NASA Astrophysics Data System (ADS)

    Salehzadeh, Sadegh; Bayat, Mehdi

    2006-08-01

    A theoretical study on complete protonation of a series of tetrabasic molecules with general formula N[(CH 2) nNH 2][(CH 2) mNH 2][(CH 2) pNH 2] (tren, pee, ppe, tpt, epb and ppb) is reported. For first time, three kinds of gas-phase proton affinities for each polybasic molecule are defined as: 'proton microaffinity (PA n, i)', 'proton macroaffinity (PA)' and 'proton overall affinity ( PA)'. The variations of calculated logPA in the series of these molecules is very similar to that of their measured log Kn. There is also a good correlation between the calculated gas-phase proton macroaffinities and proton overallaffinities with corresponding equilibrium macroconstants and overall protonation constants in solution.

  14. The Search for Proton Decay.

    ERIC Educational Resources Information Center

    Marshak, Marvin L.

    1984-01-01

    Provides the rationale for and examples of experiments designed to test the stability of protons and bound neutrons. Also considers the unification question, cosmological implications, current and future detectors, and current status of knowledge on proton decay. (JN)

  15. Proton therapy in clinical practice

    PubMed Central

    Liu, Hui; Chang, Joe Y.

    2011-01-01

    Radiation dose escalation and acceleration improves local control but also increases toxicity. Proton radiation is an emerging therapy for localized cancers that is being sought with increasing frequency by patients. Compared with photon therapy, proton therapy spares more critical structures due to its unique physics. The physical properties of a proton beam make it ideal for clinical applications. By modulating the Bragg peak of protons in energy and time, a conformal radiation dose with or without intensity modulation can be delivered to the target while sparing the surrounding normal tissues. Thus, proton therapy is ideal when organ preservation is a priority. However, protons are more sensitive to organ motion and anatomy changes compared with photons. In this article, we review practical issues of proton therapy, describe its image-guided treatment planning and delivery, discuss clinical outcome for cancer patients, and suggest challenges and the future development of proton therapy. PMID:21527064

  16. Proton range verification through prompt gamma-ray spectroscopy

    NASA Astrophysics Data System (ADS)

    Verburg, Joost M.; Seco, Joao

    2014-12-01

    We present an experimental study of a novel method to verify the range of proton therapy beams. Differential cross sections were measured for 15 prompt gamma-ray lines from proton-nuclear interactions with 12C and 16O at proton energies up to 150 MeV. These cross sections were used to model discrete prompt gamma-ray emissions along proton pencil-beams. By fitting detected prompt gamma-ray counts to these models, we simultaneously determined the beam range and the oxygen and carbon concentration of the irradiated matter. The performance of the method was assessed in two phantoms with different elemental concentrations, using a small scale prototype detector. Based on five pencil-beams with different ranges delivering 5 × 108 protons and without prior knowledge of the elemental composition at the measurement point, the absolute range was determined with a standard deviation of 1.0-1.4 mm. Relative range shifts at the same dose level were detected with a standard deviation of 0.3-0.5 mm. The determined oxygen and carbon concentrations also agreed well with the actual values. These results show that quantitative prompt gamma-ray measurements enable knowledge of nuclear reaction cross sections to be used for precise proton range verification in the presence of tissue with an unknown composition.

  17. CW high intensity non-scaling FFAG proton drivers

    SciTech Connect

    Johnstone, C.; Berz, M.; Makino, K.; Snopok, P.; /IIT, Chicago

    2011-04-01

    Accelerators are playing increasingly important roles in basic science, technology, and medicine including nuclear power, industrial irradiation, material science, and neutrino production. Proton and light-ion accelerators in particular have many research, energy and medical applications, providing one of the most effective treatments for many types of cancer. Ultra high-intensity and high-energy (GeV) proton drivers are a critical technology for accelerator-driven sub-critical reactors (ADS) and many HEP programs (Muon Collider). These high-intensity GeV-range proton drivers are particularly challenging, encountering duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons; a 10-20 MW proton driver is not presently considered technically achievable with conventional re-circulating accelerators. One, as-yet, unexplored re-circulating accelerator, the Fixed-field Alternating Gradient, or FFAG, is an attractive alternative to the cyclotron. Its strong focusing optics are expected to mitigate space charge effects, and a recent innovation in design has coupled stable tunes with isochronous orbits, making the FFAG capable of fixed-frequency, CW acceleration, as in the classical cyclotron. This paper reports on these new advances in FFAG accelerator technology and references advanced modeling tools for fixed-field accelerators developed for and unique to the code COSY INFINITY.

  18. A 5 MW TRIGA reactor design for radioisotope production

    SciTech Connect

    Veca, Anthony R.; Whittemore, William L.

    1994-07-01

    The production and preparation of commercial-scale quantities of radioisotopes has become an important activity as their medical and industrial applications continue to expand. There are currently various large multipurpose research reactors capable of producing ample quantities of radioisotopes. These facilities, however, have many competing demands placed upon them by a wide variety of researchers and scientific programs which severely limit their radioisotope production capability. A demonstrated need has developed for a simpler reactor facility dedicated to the production of radioisotopes on a commercial basis. This smaller, dedicated reactor could provide continuous fission and activation product radioisotopes to meet commercial requirements for the foreseeable future. The design of a 5 MW TRIGA reactor facility, upgradeable to 10 MW, dedicated to the production of industrial and medical radioisotopes is discussed. A TRIGA reactor designed specifically for this purpose with its demonstrated long core life and simplicity of operation would translate into increased radioisotope production. As an example, a single TRIGA could supply the entire US needs for Mo-99. The facility is based on the experience gained by General Atomics in the design, installation, and construction of over 60 other TRIGAs over the past 35 years. The unique uranium-zirconium hydride fuel makes TRIGA reactors inexpensive to build and operate, reliable in their simplicity, highly flexible due to unique passive safety, and environmentally friendly because of minimal power requirements and long-lived fuel. (author)

  19. Initial Testing of a 140 GHz 1 MW Gyrotron

    NASA Astrophysics Data System (ADS)

    Cauffman, Stephen; Felch, Kevin; Blank, Monica; Borchard, Philipp; Cahalan, Pat; Chu, Sam; Jory, Howard

    2001-10-01

    CPI has completed the fabrication of a 140 GHz 1 MW CW gyrotron to be used on the W7-X stellarator at IPP Greifswald. Testing of the initial build of this gyrotron had just begun when this abstract was prepared, and was expected to finish in September, at which time a planned rebuild of the device was scheduled to begin. This poster will summarize the gyrotron design, present results of initial testing, and outline any design changes planned as a consequence of these results. This gyrotron's design employs a number of advanced features, including a diode electron gun for simplified operation, a single-stage depressed collector to enhance overall efficiency, a CVD diamond output window, an internal mode converter that converts the excited TE28,7 cavity mode to a Gaussian output beam, and a high-voltage layout that locates all external high voltage below the superconducting magnet system without requiring an oil tank for insulation. Similar features are being used for an 84 GHz 500 kW system being built for the KSTAR tokamak program and for a 110 GHz 1.5 MW system being designed in collaboration with MIT, UMd, UW, GA, and Calabazas Creek Research with funding provided by DOE.

  20. R and D of superconductors for 70MW class generators

    SciTech Connect

    Chiba, Hiroki; Uno, Naoki; Ichikawa, Tatsumi; Meguro, S.; Takahashi, K.; Saitou, T.; Sakai, S.; Akita, S.

    1996-07-01

    Super-GM has been developing 70MW class superconducting generators (model machines) for 200MW class pilot generator. Three types of NbTi conductors were developed for each of three model machines. Regarding to the high stability type conductors, residual resistance value of 6.5{micro}{Omega}/m was achieved by adopting Al stabilizer. Regarding to the high current density type, Ic of 13.8kA at 5T was realized by reducing void fraction in conductors and maintaining high residual resistivity ratio. For the low AC loss type, high Jc and low AC loss (8.1kW/m{sup 3}) have been succeeded by applying strand insulation and two stage cabling. To confirm superconducting characteristics concerning long-term reliability, Ic and AC loss of each conductors were measured under 10,000 times repeated compressive force of 30MPa that is supposed in daily start and stop operation of generator for 30 years. In parallel to the R and D of NbTi conductors, R and D of Nb{sub 3}Sn conductors were also conducted for enhancement of critical current density and critical magnetic field.

  1. Protons Trigger Mitochondrial Flashes.

    PubMed

    Wang, Xianhua; Zhang, Xing; Huang, Zhanglong; Wu, Di; Liu, Beibei; Zhang, Rufeng; Yin, Rongkang; Hou, Tingting; Jian, Chongshu; Xu, Jiejia; Zhao, Yan; Wang, Yanru; Gao, Feng; Cheng, Heping

    2016-07-26

    Emerging evidence indicates that mitochondrial flashes (mitoflashes) are highly conserved elemental mitochondrial signaling events. However, which signal controls their ignition and how they are integrated with other mitochondrial signals and functions remain elusive. In this study, we aimed to further delineate the signal components of the mitoflash and determine the mitoflash trigger mechanism. Using multiple biosensors and chemical probes as well as label-free autofluorescence, we found that the mitoflash reflects chemical and electrical excitation at the single-organelle level, comprising bursting superoxide production, oxidative redox shift, and matrix alkalinization as well as transient membrane depolarization. Both electroneutral H(+)/K(+) or H(+)/Na(+) antiport and matrix proton uncaging elicited immediate and robust mitoflash responses over a broad dynamic range in cardiomyocytes and HeLa cells. However, charge-uncompensated proton transport, which depolarizes mitochondria, caused the opposite effect, and steady matrix acidification mildly inhibited mitoflashes. Based on a numerical simulation, we estimated a mean proton lifetime of 1.42 ns and diffusion distance of 2.06 nm in the matrix. We conclude that nanodomain protons act as a novel, to our knowledge, trigger of mitoflashes in energized mitochondria. This finding suggests that mitoflash genesis is functionally and mechanistically integrated with mitochondrial energy metabolism. PMID:27463140

  2. High Power Proton Facilities

    NASA Astrophysics Data System (ADS)

    Nagaitsev, Sergei

    2015-04-01

    This presentation will provide an overview of the capabilities and challenges of high intensity proton accelerators, such as J-PARC, Fermilab MI, SNS, ISIS, PSI, ESS (in the future) and others. The presentation will focus on lessons learned, new concepts, beam loss mechanisms and methods to mitigate them.

  3. Intensity modulated proton therapy.

    PubMed

    Kooy, H M; Grassberger, C

    2015-07-01

    Intensity modulated proton therapy (IMPT) implies the electromagnetic spatial control of well-circumscribed "pencil beams" of protons of variable energy and intensity. Proton pencil beams take advantage of the charged-particle Bragg peak-the characteristic peak of dose at the end of range-combined with the modulation of pencil beam variables to create target-local modulations in dose that achieves the dose objectives. IMPT improves on X-ray intensity modulated beams (intensity modulated radiotherapy or volumetric modulated arc therapy) with dose modulation along the beam axis as well as lateral, in-field, dose modulation. The clinical practice of IMPT further improves the healthy tissue vs target dose differential in comparison with X-rays and thus allows increased target dose with dose reduction elsewhere. In addition, heavy-charged-particle beams allow for the modulation of biological effects, which is of active interest in combination with dose "painting" within a target. The clinical utilization of IMPT is actively pursued but technical, physical and clinical questions remain. Technical questions pertain to control processes for manipulating pencil beams from the creation of the proton beam to delivery within the patient within the accuracy requirement. Physical questions pertain to the interplay between the proton penetration and variations between planned and actual patient anatomical representation and the intrinsic uncertainty in tissue stopping powers (the measure of energy loss per unit distance). Clinical questions remain concerning the impact and management of the technical and physical questions within the context of the daily treatment delivery, the clinical benefit of IMPT and the biological response differential compared with X-rays against which clinical benefit will be judged. It is expected that IMPT will replace other modes of proton field delivery. Proton radiotherapy, since its first practice 50 years ago, always required the highest level of

  4. Intensity modulated proton therapy

    PubMed Central

    Grassberger, C

    2015-01-01

    Intensity modulated proton therapy (IMPT) implies the electromagnetic spatial control of well-circumscribed “pencil beams” of protons of variable energy and intensity. Proton pencil beams take advantage of the charged-particle Bragg peak—the characteristic peak of dose at the end of range—combined with the modulation of pencil beam variables to create target-local modulations in dose that achieves the dose objectives. IMPT improves on X-ray intensity modulated beams (intensity modulated radiotherapy or volumetric modulated arc therapy) with dose modulation along the beam axis as well as lateral, in-field, dose modulation. The clinical practice of IMPT further improves the healthy tissue vs target dose differential in comparison with X-rays and thus allows increased target dose with dose reduction elsewhere. In addition, heavy-charged-particle beams allow for the modulation of biological effects, which is of active interest in combination with dose “painting” within a target. The clinical utilization of IMPT is actively pursued but technical, physical and clinical questions remain. Technical questions pertain to control processes for manipulating pencil beams from the creation of the proton beam to delivery within the patient within the accuracy requirement. Physical questions pertain to the interplay between the proton penetration and variations between planned and actual patient anatomical representation and the intrinsic uncertainty in tissue stopping powers (the measure of energy loss per unit distance). Clinical questions remain concerning the impact and management of the technical and physical questions within the context of the daily treatment delivery, the clinical benefit of IMPT and the biological response differential compared with X-rays against which clinical benefit will be judged. It is expected that IMPT will replace other modes of proton field delivery. Proton radiotherapy, since its first practice 50 years ago, always required the

  5. LIP: The Livermore Interpolation Package, Version 1.4

    SciTech Connect

    Fritsch, F N

    2011-07-06

    or invert the interpolant at an arbitrary number of points. The first section of this report describes the overall design of the package, including both forward and inverse interpolation. Sections 2-6 describe each interpolation method in detail. The software that implements this design is summarized function-by-function in Section 7. For a complete example of package usage, refer to Section 8. The report concludes with a few brief notes on possible software enhancements. For guidance on adding other functional forms to LIP, refer to Appendix B. The reader who is primarily interested in using LIP to solve a problem should skim Section 1, then skip to Sections 7.1-4. Finally, jump ahead to Section 8 and study the example. The remaining sections can be referred to in case more details are desired. Changes since version 1.1 of this document include the new Section 3.2.1 that discusses derivative estimation and new Section 6 that discusses the birational interpolation method. Section numbers following the latter have been modified accordingly.

  6. Low NO{sub x} burner retrofits to 240 MW, 300 MW and 400 MW oil/gas fired utility boilers; Final performance results and lessons learned

    SciTech Connect

    Kuretski, J.J. Jr.; Price, J.V.; Schindler, E.S.; Guarco, J.P.

    1996-12-31

    Low NO{sub x} burners (LNBs) and new windbox baffles were retrofitted to eight residual oil/gas fired boilers totaling 2,680 MW of generating capacity in the Florida Power and Light Co. (FPL) system. These TODD Combustion designed LNBs were installed, from 1992 to 1995, to comply with a NO{sub x} Reasonably Available Control Technology (R.A.C.T.) determination associated with a moderate ozone non-attainment area in south Florida. LNBs were the primary means of NO{sub x} emission rate reduction, with an objective to achieve the maximum NO{sub x} reduction possible through burner hardware changes. Accordingly, the full focus of the project was on the capabilities of state-of-the-art LNB technology. These LNB retrofits were deemed successful based on the significant NO{sub x} reductions that were achieved. FPL`s contract requirements included consideration of unit performance and boiler component life impacts in addition to the traditional emission parameter guarantees. In striving to simultaneously meet all contract requirements, various burner design adjustments were implemented. As the project progressed, much was learned about LNBs and their effects on utility boilers as well as the effects of boiler equipment design and boiler conditions on NO{sub x} emission rates.

  7. Synthesis of 1,4-dihydrophosphinoline 1-oxides by acid-promoted cyclization of 1-(diphenylphosphoryl)allenes.

    PubMed

    Bogachenkov, Alexander S; Dogadina, Albina V; Boyarskaya, Irina A; Boyarskiy, Vadim P; Vasilyev, Aleksander V

    2016-01-28

    1-(Diphenylphosphoryl)alka-1,2-dienes (phosphonoallenes) in Brønsted (super)acids (TfOH, FSO3H, H2SO4) gave the corresponding 1,2-oxaphosphol-3-enium ions, that were studied by means of NMR and DFT calculations. Upon hydrolysis of reaction solution, these cations afforded 3-hydroxyalk-2-en-1-yl-diphenylphosphine oxides (phosphonoallyl alcohols). But in (super)acids the cations were slowly transformed into O-protonated forms of 1-phenyl-1,4-dihydrophosphinoline 1-oxides, which were monitored by NMR. The latter phosphaheterocycles can be directly obtained from phosphonoallenes under the action of Lewis acid AlCl3. PMID:26666315

  8. Recent performance and ignition tests of the pulsed SNS H- source for 1-MW neutron production

    NASA Astrophysics Data System (ADS)

    Stockli, Martin P.; Han, B. X.; Murray, S. N.; Pennisi, T. R.; Piller, C.; Santana, M.; Welton, R. F.

    2015-04-01

    After acquiring several reliable spare targets, SNS ramped the beam power from 850 kW to 1.4 MW, which required an increase in H- beam pulse length from 0.88 to 1.0 ms at 60 Hz. This increase initially produced slow 2-MHz power ramp-ups and, after several weeks of uninterrupted operation, it produced plasma outages every time the pulse length was raised above ˜0.95 ms. Similar outages were previously observed towards the end of long service cycles, which were believed to indicate that the breakdown voltage of the high purity hydrogen started to exceed the induced electric fields. In 2011 the RF was reconfigured to start with 10 cycles of 1.96 MHz, which yielded the shortest H- beam rise times and apparently eliminated those plasma outages. The new, pulse-length dependent outages were eliminated by increasing the initial frequency to 1.985 MHz. However, careful frequency studies are unable to justify this frequency. In addition, the paper discusses the issues and solutions for the electron-dump voltage, which starts to sag and become unstable after several weeks of high current operation. At the request of the authors and the Proceedings Editor this article has been updated to include References 3-13, which were present in the author's original submission but were lost during manuscript processing in the Proceedings Editor's office. The updated article was published on 5 May 2015.

  9. Recent Performance and Ignition Tests of the pulsed SNS H- Source for 1-MW Neutron Production

    SciTech Connect

    Stockli, Martin P; Han, Baoxi; Murray, Jr, S N; Pennisi, Terry R; Piller, Chip; Santana, Manuel; Welton, Robert F

    2015-01-01

    After acquiring several reliable spare targets, SNS ramped the beam power from 850 kW to 1.4 MW, which required an increase in H- beam pulse length from 0.88 to 1.0 ms at 60 Hz. This increase initially produced slow 2-MHz power ramp-ups and, after several weeks of uninterrupted operation, it produced plasma outages every time the pulse length was raised above ~0.95 ms. Similar outages were previously observed towards the end of long service cycles, which were believed to indicate that the breakdown voltage of the high purity hydrogen started to exceed the induced electric fields. In 2011 the RF was reconfigured to start with 10 cycles of 1.96 MHz, which yielded the shortest H- beam rise times and apparently eliminated those plasma outages. The new, pulse-length dependent outages were eliminated by increasing the initial frequency to 1.985 MHz. However, careful frequency studies are unable to justify this frequency. In addition, the paper discusses the issues and solutions for the electron-dump voltage, which starts to sag and become unstable after several weeks of high current operation.

  10. Lamellar crystals as proton conductors to enhance the performance of proton exchange membrane for direct methanol fuel cell

    NASA Astrophysics Data System (ADS)

    Zhao, Yuning; Jiang, Zhongyi; Xiao, Lulu; Xu, Tao; Wu, Hong

    2011-08-01

    Zirconium glyphosate (ZrG) is a solid proton conductor with layered crystal structure. The inorganic veneer sheets of ZrG are covalently intercalated by glyphosate molecules with carboxylic acid end groups (-COOH). The existence of abundant -COOH groups both inside and on the surface of ZrG provides additional proton-conducting channels facilitating the proton conduction through and around the inorganic crystals. ZrG is incorporated into the sulfonated polyether ether ketone (SPEEK) matrices to prepare proton-conducting hybrid membranes. The conductivity of the hybrid membranes is higher than the pristine SPEEK membrane, and increases with increasing ZrG content. Furthermore, the enhancement of the proton conductivity is more obvious at elevated temperatures. At 25 °C, the proton conductivity of the hybrid membrane with 16 wt% ZrG is 1.4 times higher than that of the pristine membrane. When the temperature increases to 55 °C, the conductivity of the hybrid membrane with 8 wt% ZrG is more than twice that of the pristine SPEEK membrane. The prolonged and tortuous pathways originated from the incorporation of inorganic crystals lead to reduced methanol permeability. The selectivity of the hybrid membrane is increased by as much as 72% compared to the pristine SPEEK membrane.

  11. Analysis of the rotational structure in the high-resolution infrared spectra of cis,cis- and trans,trans-1,4-difluorobutadiene-1-d1 and trans,trans-1,4-difluorobutadiene-1,4-d2

    SciTech Connect

    Craig, Norman C.; Chen, Yihui; Lu, Yuhua; Neese, Christopher F.; Nemchick, Deacon J.; Blake, Thomas A.

    2013-06-01

    Samples of cis,cis- and trans,trans-1,4-difluorobutadiene-1- d1 and of trans,trans-1,4-difluorobutadiene-1,4-d2 have been synthesized, and high-resolution (≤0.0018 cm-1) infrared spectra of these substances have been recorded in the gas phase. Analysis of the rotational structure, mostly in C-type bands, has yielded ground state rotational constants. For the two 1-d1 species more than one band has been analyzed. For the 1,4-d2 species only one band was available for analysis. However, good agreement between the experimental centrifugal distortion constants and those predicted with a B3LYP/cc-pVTZ model give strong support to the analysis of the very dense spectrum. The ground state rotational constants are a contribution to finding semiexperimental equilibrium structures of the two nonpolar isomers of 1,4- difluorobutadiene.

  12. Design of a new main injector cavity for the Fermilab Proton Driver era

    SciTech Connect

    Wu, V.; Chen, A.; Qian, Z.; Wildman, D.W.; /Fermilab

    2005-05-01

    In the design report of the Fermilab Proton Driver [1], the Main Injector (MI) needs to be upgraded to a 2 MW machine. For the Main Injector radiofrequency (rf) upgrade, R&D efforts are launched to design and build a new rf system. This paper presents the new cavity design study for the rf system. The cavity is simulated with the design code Mafia [2].

  13. Proton radiography and tomography with application to proton therapy

    PubMed Central

    Allinson, N M; Evans, P M

    2015-01-01

    Proton radiography and tomography have long promised benefit for proton therapy. Their first suggestion was in the early 1960s and the first published proton radiographs and CT images appeared in the late 1960s and 1970s, respectively. More than just providing anatomical images, proton transmission imaging provides the potential for the more accurate estimation of stopping-power ratio inside a patient and hence improved treatment planning and verification. With the recent explosion in growth of clinical proton therapy facilities, the time is perhaps ripe for the imaging modality to come to the fore. Yet many technical challenges remain to be solved before proton CT scanners become commonplace in the clinic. Research and development in this field is currently more active than at any time with several prototype designs emerging. This review introduces the principles of proton radiography and tomography, their historical developments, the raft of modern prototype systems and the primary design issues. PMID:26043157

  14. Proton radiography and tomography with application to proton therapy.

    PubMed

    Poludniowski, G; Allinson, N M; Evans, P M

    2015-09-01

    Proton radiography and tomography have long promised benefit for proton therapy. Their first suggestion was in the early 1960s and the first published proton radiographs and CT images appeared in the late 1960s and 1970s, respectively. More than just providing anatomical images, proton transmission imaging provides the potential for the more accurate estimation of stopping-power ratio inside a patient and hence improved treatment planning and verification. With the recent explosion in growth of clinical proton therapy facilities, the time is perhaps ripe for the imaging modality to come to the fore. Yet many technical challenges remain to be solved before proton CT scanners become commonplace in the clinic. Research and development in this field is currently more active than at any time with several prototype designs emerging. This review introduces the principles of proton radiography and tomography, their historical developments, the raft of modern prototype systems and the primary design issues. PMID:26043157

  15. Exploring universality of transversity in proton-proton collisions

    NASA Astrophysics Data System (ADS)

    Radici, Marco; Ricci, Alessandro M.; Bacchetta, Alessandro; Mukherjee, Asmita

    2016-08-01

    We consider the azimuthal correlations of charged hadron pairs with large total transverse momentum and small relative momentum, produced in proton-proton collisions with one transversely polarized proton. One of these correlations directly probes the chiral-odd transversity parton distribution in connection with a chiral-odd interference fragmentation function. We present predictions for this observable based on previous extractions of transversity (from charged pion pair production in semi-inclusive deep-inelastic scattering) and of the interference fragmentation function (from the production of back-to-back charged pion pairs in electron-positron annihilations). All analyses are performed in the framework of collinear factorization. We compare our predictions to the recent data on proton-proton collisions released by the STAR Collaboration at RHIC, and we find them reasonably compatible. This comparison confirms for the first time the predicted role of transversity in proton-proton collisions, and it allows us to test its universality.

  16. Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) for dual biosensing of pH with CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts)

    PubMed Central

    Huang, Yuegao; Coman, Daniel; Ali, Meser M.; Hyder, Fahmeed

    2014-01-01

    Relaxivity based magnetic resonance of phosphonated ligands chelated with gadolinium (Gd3+) shows promise for pH imaging. However instead of monitoring the paramagnetic effect of lanthanide complexes on the relaxivity of water protons, biosensor (or molecular) imaging with magnetic resonance is also possible by detecting either the non-exchangeable or the exchangeable protons on the lanthanide complexes themselves. The non-exchangeable protons (e.g., –CHx, where 3≥x≥1) are detected using a three-dimensional chemical shift imaging method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), whereas the exchangeable protons (e.g., –OH or –NHy, where 2≥y≥1) are measured with Chemical Exchange Saturation Transfer (CEST) contrast. Here we tested the feasibility of BIRDS and CEST for pH imaging of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) chelated with thulium (Tm3+) and ytterbium (Yb3+). BIRDS and CEST experiments show that both complexes are responsive to pH and temperature changes. Higher pH and temperature sensitivities are obtained with BIRDS for either complex when using the chemical shift difference between two proton resonances vs. using the chemical shift of a single proton resonance, thereby eliminating the need to use water resonance as reference. While CEST contrast for both agents is linearly dependent on pH within a relatively large range (i.e., 6.3-7.9), much stronger CEST contrast is obtained with YbDOTA-4AmP5− than with TmDOTA-4AmP5−. In addition, we demonstrate the prospect of using BIRDS to calibrate CEST as new platform for quantitative pH imaging. PMID:24801742

  17. Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons

    PubMed Central

    Goodwin, A. K.; Brown, P. R.; Jansen, E. E. W.; Jakobs, C.; Gibson, K. M.; Weerts, E. M.

    2009-01-01

    Rationale Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are prodrugs for gamma-hydroxybutyrate (GHB). Like GHB, GBL and 1,4-BD are drugs of abuse, but their behavioral effects may differ from GHB under some conditions. Objectives The first study compared the behavioral effects of GBL (32−240 mg/kg) and 1,4-BD (32−240 mg/kg) with each other and to effects previously reported for GHB (32−420 mg/kg). A second study determined GHB pharmacokinetics following intragastric administration of GHB, GBL, and 1,4-BD. Methods Operant responding for food, observed behavioral effects, and a fine-motor task occurred at multiple time intervals after administration of drug or vehicle. In a separate pharmacokinetics study, blood samples were collected across multiple time points after administration of GHB, GBL, and 1,4-BD. Results Like GHB, GBL, and 1,4-BD impaired performance on the fine-motor task, but the onset of motor impairment differed across drugs. GBL and 1,4-BD dose dependently decreased the number of food pellets earned, but at lower doses than previously observed for GHB. Similar to GHB, both GBL and 1,4-BD produced sedation, muscle relaxation, gastrointestinal symptoms, and tremors/jerks. Administration of GBL and 1,4-BD produced higher maximum concentrations of GHB with shorter times to maximum concentrations of GHB in plasma when compared to GHB administration. Conclusions GBL and 1,4-BD produced behavioral effects similar to those previously reported with GHB and the time course of effects were related to blood levels of GHB. Given their higher potency and faster onset of effects, the abuse liability of GBL and 1,4-BD may be greater than GHB. PMID:19198808

  18. Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): Time course and severity of withdrawal in baboons

    PubMed Central

    Goodwin, Amy K.; Gibson, K. Michael; Weerts, Elise M.

    2013-01-01

    Background 1,4-butanediol (1,4-BD) is a gamma-hydroxybutyrate (GHB) pro-drug, with multiple commercial uses, and a drug of abuse. Although there are case reports of a withdrawal syndrome following 1,4-BD use, no studies have evaluated the physical dependence potential of 1,4-BD and characterized the time course of withdrawal. Methods Vehicle and then 1,4-BD were administered continuously 24 h/day via intragastric catheters in male baboons (Papio anubis, n=3). Dosing was initiated at 100 mg/kg and increased by 100 mg/kg/day to 400 mg/kg. After a stabilization period, doses of 500 and then 600 mg/kg/day were each maintained for 3-4 weeks. Plasma levels of 1,4-BD and GHB were determined for each dose condition. Physical dependence was assessed via administration of a GABA-B antagonist (precipitated withdrawal test) during administration of the 600 mg/kg dose and via abrupt termination of chronic 1,4-BD administration (spontaneous withdrawal test). Outcome measures included the number of food pellets earned, performance on a fine-motor task, observed behaviors, and plasma levels of GHB and 1,4-BD. Results Following maintenance of 1,4-BD 600 mg/kg for 3 weeks, the number of food pellets earned was significantly decreased. At the end of chronic 1,4-BD dosing, the levels of GHB in plasma ranged from 1290- 2300 μmol/L and levels of 1,4-BD in plasma ranged from 13.1 -37.9 μmol/L. Signs of physical dependence were observed following precipitated and spontaneous withdrawal tests. Seizures were not observed. Conclusions These data indicate chronic 1,4-BD produced physical dependence in baboons and the withdrawal syndrome can be characterized as mild to intermediate. PMID:23538206

  19. Twenty-Five Years of Postseismic Viscous Relaxation Following the Mw 6.9 Loma Prieta Earthquake

    NASA Astrophysics Data System (ADS)

    Huang, M. H.; Burgmann, R.; Johanson, I. A.

    2014-12-01

    The 1989 Mw 6.9 Loma Prieta earthquake provides the first opportunity of probing the crustal and upper mantle rheology in the San Francisco Bay Area since the 1906 Mw 7.9 San Francisco earthquake. Here we use geodetic observations including GPS and InSAR to characterize the 1989 Mw 6.9 Loma Prieta earthquake postseismic displacement from 1989.8 to 2013. Pre-earthquake deformation rates are constrained by nearly 20 years of USGS trilateration measurements and removed from the postseismic measurements prior to the analysis. We observe 1-4 mm/yr GPS horizontal displacement toward the Loma Prieta epicenter until 2000, and ~2 mm/yr surface subsidence of the northern Santa Cruz Mountains between 1992 and 2002, which is not associated with the seasonal and longer-term hydrological deformation in the adjoining Santa Clara Valley. Previous work indicates afterslip dominated in the early (1989-1994) postseismic period, so we focus on modeling the postseismic viscoelastic relaxation between 1994 and 2010 based on geodetic observations. The best fitting result predicts an 11-km-thick viscoelastic lower crust with viscosity of about 1019 Pa s below a 19-km-thick elastic upper crust, underlain by a bi-viscous upper mantle with transient viscosity of 1016.5-17.5 and steady-state viscosity of 1017.5-18.5 Pa s. The millimeter scale postseismic deformation does not resolve the viscosity in different layers very well, but the inferred lithospheric rheology is consistent with estimates in southern California. The viscoelastic relaxation may also contribute to the enduring increase of aseismic slip and repeating earthquake activity on the San Andreas Fault near San Juan Bautista, which continued for at least a decade after the Loma Prieta event.

  20. Greenwich turbine supplies Senegal with 25 MW in six months

    SciTech Connect

    1995-05-01

    Greenwich Turbine, Inc. (GTi) of East Granby, CT is a specialist firm in gas turbine repair/overhaul which has, in recent years, expanded into supplying gas turbine power plants in the 20- to 90-MW range. The sixteenth and latest power project was their most ambitious, a turbine plant for the West African nation of Senegal. The engine is a Pratt & Whitney FT4C-3F gas generator and power turbine. The plant was completed and commissioned on January 27, 1995, with the presidents of Senegal and Ivory Coast in attendance. The equipment is now going through a shake-down period, providing intermediate-duty power. And the GTi staff is justifiably proud of how quickly they were able to get this power online. 2 figs.

  1. 120 MW, 800 MHz Magnicon for a Future Muon Collider

    SciTech Connect

    Jay L. Hirshfield

    2005-12-15

    Development of a pulsed magnicon at 800 MHz was carried out for the muon collider application, based on experience with similar amplifiers in the frequency range between 915 MHz and 34.3 GHz. Numerical simulations using proven computer codes were employed for the conceptual design, while established design technologies were incorporated into the engineering design. A cohesive design for the 800 MHz magnicon amplifier was carried out, including design of a 200 MW diode electron gun, design of the magnet system, optimization of beam dynamics including space charge effects in the transient and steady-state regimes, design of the drive, gain, and output cavities including an rf choke in the beam exit aperture, analysis of parasitic oscillations and design means to eliminate them, and design of the beam collector capable of 20 kW average power operation.

  2. The 125 MW Upper Mahiao geothermal power plant

    SciTech Connect

    Forte, N.

    1996-12-31

    The 125 MW Upper Mahiao power plant, the first geothermal power project to be financed under a Build-Own-Operate-and-Transfer (BOOT) arrangement in the Philippines, expected to complete its start-up testing in August of this year. This plant uses Ormat`s environmentally benign technology and is both the largest geothermal steam/binary combined cycle plant as well as the largest geothermal power plant utilizing air cooled condensers. The Ormat designed and constructed plant was developed under a fast track program, with some two years from the April 1994 contract signing through design, engineering, construction and startup. The plant is owned and operated by a subsidiary of CalEnergy Co., Inc. and supplies power to PNOC-Energy Development Corporation for the National Power Corporation (Napocor) national power grid in the Philippines.

  3. Atypical soil behavior during the 2011 Tohoku earthquake ( Mw = 9)

    NASA Astrophysics Data System (ADS)

    Pavlenko, Olga V.

    2016-07-01

    To understand physical mechanisms of generation of abnormally high peak ground acceleration (PGA; >1 g) during the Tohoku earthquake, models of nonlinear soil behavior in the strong motion were constructed for 27 KiK-net stations located in the near-fault zones to the south of FKSH17. The method of data processing used was developed by Pavlenko and Irikura, Pure Appl Geophys 160:2365-2379, 2003 and previously applied for studying soil behavior at vertical array sites during the 1995 Kobe (Mw = 6.8) and 2000 Tottori (Mw = 6.7) earthquakes. During the Tohoku earthquake, we did not observe a widespread nonlinearity of soft soils and reduction at the beginning of strong motion and recovery at the end of strong motion of shear moduli in soil layers, as usually observed during strong earthquakes. Manifestations of soil nonlinearity and reduction of shear moduli during strong motion were observed at sites located close to the source, in coastal areas. At remote sites, where abnormally high PGAs were recorded, shear moduli in soil layers increased and reached their maxima at the moments of the highest intensity of the strong motion, indicating soil hardening. Then, shear moduli reduced with decreasing the intensity of the strong motion. At soft-soil sites, the reduction of shear moduli was accompanied by a step-like decrease of the predominant frequencies of motion. Evidently, the observed soil hardening at the moments of the highest intensity of the strong motion contributed to the occurrence of abnormally high PGA, recorded during the Tohoku earthquake.

  4. Smashing Protons to Smithereens

    ScienceCinema

    Marc-André Pleier

    2010-09-01

    Pleier discusses the extraordinary research taking place at the Large Hadron Collider (LHC) ? the world?s newest, biggest, and highest energy particle accelerator located at CERN. Pleier is one of hundreds of researchers from around the world working on ATLAS, a seven-story particle detector positioned at a point where the LHC?s oppositely circulating beams of protons slam into one another head-on.

  5. Ocular Proton Therapy Centers

    NASA Astrophysics Data System (ADS)

    Kacperek, Andrzej

    This chapter describes a review of proton therapy (PT) centers and the techniques used for the treatment of ocular lesions. The role of ion beam therapy (IBT) for eye treatments, principally choroidal melanomas, has become well established among the competing treatment modalities. More national centers now offer PT for these lesions, but not necessarily in a hospital environment. Significant improvements in eye treatment planning, patient positioning, and QA dosimetry have been realized, to the benefit of treatment efficiency and accuracy of dose delivery.

  6. Proton conducting cerate ceramics

    SciTech Connect

    Coffey, G.W.; Pederson, L.R.; Armstrong, T.R.; Bates, J.L.; Weber, W.J.

    1995-08-01

    Cerate perovskites of the general formula AM{sub x}Ce{sub 1-x}O{sub 3-{delta}}, where A = Sr or Ba and where M = Gd, Nd, Y, Yb or other rare earth dopant, are known to conduct a protonic current. Such materials may be useful as the electrolyte in a solid oxide fuel cell operating at intermediate temperatures, as an electrochemical hydrogen separation membrane, or as a hydrogen sensor. Conduction mechanisms in these materials were evaluated using dc cyclic voltammetry and mass spectrometry, allowing currents and activation energies for proton, electron, and oxygen ion contributions to the total current to be determined. For SrYb{sub 0.05}Ce{sub 0.95}O{sub 3-{delta}}, one of the best and most environmentally stable compositions, proton conduction followed two different mechanisms: a low temperature process, characterized by an activation energy of 0.42{+-}0.04 eV, and a high temperature process, characterized by an activation energy of 1.38{+-}0.13 eV. It is believed that the low temperature process is dominated by grain boundary conduction while bulk conduction is responsible for the high temperature process. The activation energy for oxygen ion conduction (0.97{+-}0.10 eV) agrees well with other oxygen conductors, while that for electronic conduction, 0.90{+-}0.09 eV, is affected by a temperature-dependent electron carrier concentration. Evaluated by direct measurement of mass flux through a dense ceramic with an applied dc field, oxygen ions were determined to be the majority charge carrier except at the lowest temperatures, followed by electrons and then protons.

  7. Smashing Protons to Smithereens

    SciTech Connect

    Marc-André Pleier

    2010-05-05

    Pleier discusses the extraordinary research taking place at the Large Hadron Collider (LHC) — the world’s newest, biggest, and highest energy particle accelerator located at CERN. Pleier is one of hundreds of researchers from around the world working on ATLAS, a seven-story particle detector positioned at a point where the LHC’s oppositely circulating beams of protons slam into one another head-on.

  8. Pion, Kaon, Proton and Antiproton Production in Proton-Proton Collisions

    NASA Technical Reports Server (NTRS)

    Norbury, John W.; Blattnig, Steve R.

    2008-01-01

    Inclusive pion, kaon, proton, and antiproton production from proton-proton collisions is studied at a variety of proton energies. Various available parameterizations of Lorentz-invariant differential cross sections as a function of transverse momentum and rapidity are compared with experimental data. The Badhwar and Alper parameterizations are moderately satisfactory for charged pion production. The Badhwar parameterization provides the best fit for charged kaon production. For proton production, the Alper parameterization is best, and for antiproton production the Carey parameterization works best. However, no parameterization is able to fully account for all the data.

  9. Electrochemical and photophysical behavior of 1-naphthol in benzyl-n-hexadecyldimethylammonium 1,4-bis(2-ethylhexyl)sulfosuccinate large unilamellar vesicles.

    PubMed

    Cobo Solis, Airam K; Mariano Correa, N; Molina, Patricia G

    2016-06-21

    In the present contribution, 1-naphthol is investigated in large unilamellar vesicles formed from a new catanionic surfactant, benzyl-n-hexadecyldimethylammonium 1,4-bis(2-ethylhexyl)sulfosuccinate, by electrochemical and spectroscopic techniques. The electrochemical results show that 1-naphthol experiences a partition process between the water phase and the large unilamellar vesicle bilayer phase, which is corroborated by absorption spectroscopic studies at pH = 6.40 and pH = 10.75. Interestingly, studies of 1-naphthol emission in benzyl-n-hexadecyldimethylammonium 1,4-bis(2-ethylhexyl)sulfosuccinate large unilamellar vesicles at pH = 10.75 and in sodium 1,4-bis(2-ethylhexyl)sulfosuccinate water solution show that when the 1,4-bis(2-ethylhexyl)sulfosuccinate moiety is part of the bilayer, the 1,4-bis(2-ethylhexyl)sulfosuccinate polar head interacts strongly with 1-naphthol, by favoring emission from the excited neutral species resulting in the appearance of a new band close to λ = 355 nm. It seems that the large unilamellar vesicle bilayer of the catanionic vesicle slows down the proton transfer process observed in water, where only emission from 1-naphtholate is detected. PMID:27221948

  10. Seismological Analyses of the March 11, 2010, Pichilemu, Chile Mw 7.0 and Mw 6.9 Earthquakes

    NASA Astrophysics Data System (ADS)

    Ruiz-Paredes, J. A.; Hayes, G. P.; Socquet, A.; Carrizo, D.; Kanamori, H.

    2012-12-01

    On March 11, 2010, a sequence of large, shallow continental crust earthquakes shook Central Chile. Two normal faulting events, having magnitudes Mw 7.0 and Mw 6.9, were separated by just 15 minutes, with epicenters located near the town of Pichilemu. These kinds of large intraplate inland crustal earthquake are rare above the Chilean subduction zone, and it is important to better understand their relationship with the 27 February 2010, Mw 8.8, Maule earthquake. We present a broad seismological analysis of these earthquakes by using both teleseismic and regional data. We compute seismic moment tensors of both events via a W-Phase inversion, and test sensitivities to various inversion parameters in order to assess the stability of the solutions. The first event, at 14h 39m GMT, is well constrained, displaying a fault plane with strike of N145E, and a preferred dip angle of 55SW, consistent with the trend of aftershock locations. Teleseismic finite-fault inversions for this event show a large slip zone along the southern part of the fault, correlating well with the spatial density of aftershocks reported. The second shock (14h 55 GMT) appears to have ruptured a fault branching southward from the previous ruptured fault, within the hanging wall of the first event. Modeling seismograms at regional to teleseismic distances (Δ > 5°) is quite challenging because the observed seismic wave fields of both events overlap, increasing apparent complexity for the second event. We perform both point- and extended source inversions at regional and teleseismic distances, assessing sensitivity by analyzing changes in RMS misfits as a result of variations in fault orientation, dimension, and hypocenter location. Results show that the focal mechanism for the second event features a steeper dip angle and a strike rotated slightly clockwise with respect to the previous event. This kind of geological fault configuration, with secondary rupture in the hanging wall of a large normal fault

  11. Polarized protons at RHIC

    SciTech Connect

    Makdisi, Y.

    1992-10-01

    The approval for construction of the Relativistic Heavy Ion Collider (RHIC) provides a potential opportunity to collide polarized proton beams at energies up to 500 GeV in the center of mass and high luminosities approaching 2 {times} 10{sup 32}/cm{sup 2}/sec. This capability is enhanced by the fact that the AGS has already accelerated polarized protons and relies on the newly completed Accumulator/Booster for providing the required polarized proton intensity and a system of spin rotators (Siberian snakes) to retain the polarization. The RHIC Spin Collaboration was formed and submitted a Letter of Intent to construct this polarized collider capability and utilize its physics opportunities. In this presentation, I will discuss the plans to upgrade the AGS, the proposed layout of the RHIC siberian snakes, and timetables. The physics focus is the measurement of the spin dependent parton distributions with such accessible probes including high p(t) jets, direct photons, and Drell Yan. The attainable sensitivities and the progress that has been reached in defining the detector requirements will be outlined.

  12. Polarized protons at RHIC

    SciTech Connect

    Makdisi, Y.

    1992-01-01

    The approval for construction of the Relativistic Heavy Ion Collider (RHIC) provides a potential opportunity to collide polarized proton beams at energies up to 500 GeV in the center of mass and high luminosities approaching 2 {times} 10{sup 32}/cm{sup 2}/sec. This capability is enhanced by the fact that the AGS has already accelerated polarized protons and relies on the newly completed Accumulator/Booster for providing the required polarized proton intensity and a system of spin rotators (Siberian snakes) to retain the polarization. The RHIC Spin Collaboration was formed and submitted a Letter of Intent to construct this polarized collider capability and utilize its physics opportunities. In this presentation, I will discuss the plans to upgrade the AGS, the proposed layout of the RHIC siberian snakes, and timetables. The physics focus is the measurement of the spin dependent parton distributions with such accessible probes including high p(t) jets, direct photons, and Drell Yan. The attainable sensitivities and the progress that has been reached in defining the detector requirements will be outlined.

  13. Ionospherically reflected proton whistlers

    NASA Astrophysics Data System (ADS)

    Vavilov, D. I.; Shklyar, D. R.

    2014-12-01

    We present experimental observations and detailed investigation of the variety of proton whistlers that includes transequatorial and ionospherically reflected proton whistlers. The latter have previously been indicated from numerical modeling of spectrograms. The study is based on six-component ELF wave data from the Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions (DEMETER) satellite which permits to obtain not only spectrograms displaying the power spectral density but also such wave properties as the polarization, wave normal angle, wave refractive index, and normalized parallel component of the Poynting vector. The explanation of various types of proton whistlers is based on the properties of ion cyclotron wave propagation in a multicomponent magnetoplasma, with special consideration of the effect of ion hybrid resonance reflection. Analysis of experimental data is supplemented by numerical modeling of spectrograms that reproduces the main features of experimental ones. As a self-contained result, we provide conclusive experimental evidences that the region illuminated by a lightning stroke in the Earth-ionosphere waveguide may spread over a distance of 4000 km in both hemispheres.

  14. R&D of A MW-class solid-target for a spallation neutron source

    NASA Astrophysics Data System (ADS)

    Kawai, Masayoshi; Furusaka, Michihiro; Kikuchi, Kenji; Kurishita, Hiroaki; Watanabe, Ryuzo; Li, Jing-Feng; Sugimoto, Katsuhisa; Yamamura, Tsutomu; Hiraoka, Yutaka; Abe, Katsunori; Hasegawa, Akira; Yoshiie, Masatoshi; Takenaka, Hiroyuki; Mishima, Katsuichiro; Kiyanagi, Yoshiaki; Tanabe, Tetsuo; Yoshida, Naoaki; Igarashi, Tadashi

    2003-05-01

    R&D for a MW-class solid target composed of tungsten was undertaken to produce a pulsed intense neutron source for a future neutron scattering-facility. In order to solve the corrosion of tungsten, tungsten target blocks were clad with tantalum by means of HIP'ing, brazing and electrolytic coating in a molten salt bath. The applicability of the HIP'ing method was tested through fabricating target blocks for KENS (spallation neutron source at KEK). A further investigation to certify the optimum HIP conditions was made with the small punch test method. The results showed that the optimum temperature was 1500 °C at which the W/Ta interface gave the strongest fracture strength. In the case of the block with a hole for thermocouple, it was found that the fabrication preciseness of a straight hole and a tantalum sheath influenced the results. The development of a tungsten stainless-steel alloy was tried to produce a bare tungsten target, using techniques in powder metallurgy. Corrosion tests for various tungsten alloys were made while varying the water temperature and velocity. The mass loss of tungsten in very slow water at 180 °C was as low as 0.022 mg/y, but increased remarkably with water velocity. Simulation experiments for radiation damage to supplement the STIP-III experiments were made to investigate material hardening by hydrogen and helium, and microstructures irradiated by electrons. Both experiments showed consistent results on the order of the dislocation numbers and irradiation hardness among the different tungsten materials. Thermal-hydraulic designs were made for two types of solid target system of tungsten: slab and rod geometry as a function of the proton beam power. The neutronic performance of a solid target system was compared with that of mercury target based on Monte Carlo calculations by using the MCNP code.

  15. Design of Injection and Extraction at an 8-GeV Booster Ring and the J-PARC Main Ring for Multi-MW Output Beam Power

    NASA Astrophysics Data System (ADS)

    Harada, Hiroyuki; Hotchi, Hideaki; Igarashi, Susumu; Sato, Yoichi; Koseki, Tadashi

    The 240-kW output beam power in the MR has been achieved for a 30-GeV user operation with the repetition cycle of 2.48 sec and injecting proton beams of 380-kW equivalent intensity from RCS. The MR aims to realize 750-kW beam operation with faster repetition cycle of ˜1 s and injecting proton beams of 600-kW equivalent intensity from RCS. The MR is developing the new type power supplies of MR main magnets and high-impedance core of MR RF cavities toward faster repetition cycle. We are now exploring the further beam power upgrade scenario of the J-PARC accelerators. As one possible scenario toward a multi-MW output beam power from MR, a new 8-GeV booster ring (BR) between RCS and MR is also designed. The injection energy of the MR increases from present 3-GeV to 8-GeV. The higher injection energy of the MR would be able to mitigate a space charge force in MR injection energy region and secure the acceptance clearance of beam from MR physical aperture. In this paper, the designed injection and extraction system of BR are described. Additionally, a new concept of BR extraction and MR injection toward multi-MW output beam power are described.

  16. Crystal structures, UV spectra of solid iodide anionic water clusters I(-)(H2O)(1-4), and electrochemical reaction of I(-)(H2O)(1-4) → I· + e(-)(H2O)(1-4).

    PubMed

    Qiu, Yanxuan; Yang, Meng; Chen, Wenbin; Su, Yuzhi; Ouyang, Zhenjie; Yan, Hua; Gao, Feixian; Dong, Wen

    2013-05-16

    Four iodide anionic water clusters of I(-)(H2O)1-4 in two supramolecular complexes of [Fe(phen)3][I2(H2O)3] (1) and [Zn(phen)3][I2(H2O)4.5] (2) have been determined by single-crystal X-ray diffraction analysis. The diffuse reflectance spectra for the solid iodide anionic water clusters of I(-)(H2O)1-4 were investigated, and their absorption bands were demonstrated by denisty functional theory calculation. The electrochemical reaction of I(-)(H2O)1-4 → I· + e(-)(H2O)1-4 with the oxidation potential of Ep = 0.61 eV was first found and reported in two aqueous solutions (1 mmol·dm(-3)) of 1 and 2. PMID:23614806

  17. 40 CFR 180.1142 - 1,4-Dimethylnaphthalene; exemption from the requirement of a tolerance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... tolerance. An exemption from the requirement of a tolerance is established for the residues of the plant growth regulator, 1,4-dimethylnaphthalene (1,4-DMN), when applied postharvest to all sprouting...

  18. Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate.

    PubMed Central

    Hirata, M; Takeuchi, H; Riley, A M; Mills, S J; Watanabe, Y; Potter, B V

    1997-01-01

    The Ins(1,4,5)P3 regioisomers, Ins(1,4,6)P3 and Ins(1,3,6)P3, which can mimic the 1,4,5-arrangement on the inositol ring of Ins(1,4,5)P3, were examined for Ca2+ release by using four types of saponin-permeabilized cell possessing various abundances of receptor subtypes, with special reference to the relation of potency to receptor subtype. Ins(1,4,6)P3 and Ins(1,3,6)P3 were weak agonists in rat basophilic leukaemic cells (RBL cells), which possess predominantly subtype II receptors, with respective potencies of 1/200 and less than 1/500 that of Ins(1,4,5)P3 [the EC50 values were 0.2, 45 and more than 100 microM for Ins(1,4,5)P3, Ins(1,4,6)P3 and Ins(1,3,6)P3 respectively]. Similar rank order potencies were also evaluated for the displacement of [3H]Ins(1,4,5)P3 bound to RBL cell membranes by these regioisomers. However, they caused Ca2+ release from GH3 rat pituitary cells possessing predominantly subtype I receptors more potently; Ins(1,4,6)P3 and Ins(1,3,6)P3 evoked release at respective concentrations of only one-third and one-twentieth that of Ins(1,4,5)P3 (the EC50 values were 0.4, 1.2 and 8 microM for Ins(1,4,5)P3, Ins(1,4,6)P3 and Ins(1,3,6)P3 respectively). In COS-1 African green-monkey kidney cells, with the relative abundances of 37% of the subtype II and of 62% of the subtype III receptor, potencies of 1/40 and approx. 1/200 for Ins(1, 4,6)P3 and Ins(1,3,6)P3 respectively were exhibited relative to Ins(1,4,5)P3 (the EC50 values were 0.4, 15 and approx. 80 microM for Ins(1,4,5)P3, Ins(1,4,6)P3 and Ins(1,3,6)P3 respectively). In HL-60 human leukaemic cells, in spite of the dominant presence of subtype I receptors (71%), similar respective potencies to those seen with COS-1 cells were exhibited (the EC50 values were 0.3, 15 and approx. 100 microM for Ins(1,4,5)P3, Ins(1,4,6)P3 and Ins(1,3,6)P3 respectively). These results indicate that these regioisomers are the first ligands that distinguish between receptor subtypes; the present observations are of

  19. Plans for a proton driver at Fermilab

    SciTech Connect

    Kephart, R.D.; /Fermilab

    2005-01-01

    , and will certainly have important implications for our understanding of cosmology and the evolution of the early Universe. The current Fermilab Program is an important part of the world-wide accelerator based effort to explore and understand the physics of neutrino oscillations. By early 2005, with both MINOS and MiniBooNE taking data, Fermilab will be able to answer some of the most pressing first-round questions raised by the discovery that neutrinos have mass. Fermilab's high-intensity neutrino beams are derived from 8- and 120-GeV proton beams. MiniBooNE is currently taking data using 8 GeV Protons from the Booster. The 120 GeV NuMI beam will start to operate in early 2005 using a 0.25 MW proton beam power from the Main Injector. Future neutrino programs will build on these existing facilities. New short and long baseline experiments have been proposed. There are proposals to increase the available number of protons at 8 and 120 GeV with the goal of addressing the full range of questions presented by neutrino oscillations. Key to that vision is a new intense proton source that usually is referred to as the Proton Driver.

  20. 49 CFR 173.64 - Exceptions for Division 1.3 and 1.4 fireworks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Exceptions for Division 1.3 and 1.4 fireworks. 173... § 173.64 Exceptions for Division 1.3 and 1.4 fireworks. (a) Notwithstanding the requirements of § 173.56(b), Division 1.3 and 1.4 fireworks (see § 173.65 for Division 1.4G consumer fireworks) may...

  1. 49 CFR 173.64 - Exceptions for Division 1.3 and 1.4 fireworks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Exceptions for Division 1.3 and 1.4 fireworks. 173... § 173.64 Exceptions for Division 1.3 and 1.4 fireworks. (a) Notwithstanding the requirements of § 173.56(b), Division 1.3 and 1.4 fireworks (see § 173.65 for Division 1.4G consumer fireworks) may...

  2. Design and test of a 2.25-MW transformer rectifier assembly

    NASA Technical Reports Server (NTRS)

    Cormier, R.; Daeges, J.

    1989-01-01

    A new 2.25-MW transformer rectifier assembly was fabricated for DSS-13 at Goldstone, California. The transformer rectifier will provide constant output power of 2.25 MW at any voltage from 31 kV to 125 kV. This will give a new capability of 1 MW of RF power at X-band, provided appropriate microwave tubes are in the power amplifier. A description of the design and test results is presented.

  3. 2 MW 110 GHz ECH heating system for DIII-D

    SciTech Connect

    Moeller, C.; Prater, R.; Callis, R.; Remsen, D.; Doane, J.; Cary, W.; Phelps, R.; Tupper, M.

    1990-09-01

    A 2 MW 110 GHz ECH system using Varian 0.5 MW gyrotrons is under construction for use on the DIII-D tokamak by late 1991. Most of the components are being design and fabricated at General Atomics, including the gyrotron tanks, superconducting magnets, and transmission line. These components are intended for operation with 10 second pulses and, in the future, with 1 MW gyrotrons. 6 refs., 5 figs.

  4. 10 CFR 960.3-1-4-3 - Site recommendation for characterization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Site recommendation for characterization. 960.3-1-4-3 Section 960.3-1-4-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-3 Site...

  5. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The...

  6. 10 CFR 960.3-1-4-1 - Site identification as potentially acceptable.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Site identification as potentially acceptable. 960.3-1-4-1 Section 960.3-1-4-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-1 Site...

  7. 10 CFR 960.3-1-4-3 - Site recommendation for characterization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Site recommendation for characterization. 960.3-1-4-3 Section 960.3-1-4-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-3 Site...

  8. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The...

  9. 43 CFR 3135.1-4 - Effect of transfer of a tract.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Effect of transfer of a tract. 3135.1-4 Section 3135.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... RESERVE, ALASKA Transfers, Extensions, Consolidations, and Suspensions § 3135.1-4 Effect of transfer of...

  10. 43 CFR 3135.1-4 - Effect of transfer of a tract.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Effect of transfer of a tract. 3135.1-4 Section 3135.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... RESERVE, ALASKA Transfers, Extensions, Consolidations, and Suspensions § 3135.1-4 Effect of transfer of...

  11. 43 CFR 3135.1-4 - Effect of transfer of a tract.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Effect of transfer of a tract. 3135.1-4 Section 3135.1-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... RESERVE, ALASKA Transfers, Extensions, Consolidations, and Suspensions § 3135.1-4 Effect of transfer of...

  12. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN...

  13. 40 CFR 721.1193 - Benzene, 2-bromo-1,4-dimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Benzene, 2-bromo-1,4-dimethoxy-. 721... Substances § 721.1193 Benzene, 2-bromo-1,4-dimethoxy-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 2-bromo-1,4-dimethoxy- (PMN...

  14. 40 CFR 721.1193 - Benzene, 2-bromo-1,4-dimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Benzene, 2-bromo-1,4-dimethoxy-. 721... Substances § 721.1193 Benzene, 2-bromo-1,4-dimethoxy-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 2-bromo-1,4-dimethoxy- (PMN...

  15. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN...

  16. 40 CFR 721.1193 - Benzene, 2-bromo-1,4-dimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Benzene, 2-bromo-1,4-dimethoxy-. 721... Substances § 721.1193 Benzene, 2-bromo-1,4-dimethoxy-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 2-bromo-1,4-dimethoxy- (PMN...

  17. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN...

  18. 40 CFR 721.1193 - Benzene, 2-bromo-1,4-dimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Benzene, 2-bromo-1,4-dimethoxy-. 721... Substances § 721.1193 Benzene, 2-bromo-1,4-dimethoxy-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 2-bromo-1,4-dimethoxy- (PMN...

  19. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN...

  20. 40 CFR 721.1193 - Benzene, 2-bromo-1,4-dimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Benzene, 2-bromo-1,4-dimethoxy-. 721... Substances § 721.1193 Benzene, 2-bromo-1,4-dimethoxy-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 2-bromo-1,4-dimethoxy- (PMN...

  1. 40 CFR 721.10096 - Benzene, 1,4-bis (methoxymethyl)-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Benzene, 1,4-bis (methoxymethyl)-. 721... Substances § 721.10096 Benzene, 1,4-bis (methoxymethyl)-. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as benzene, 1,4-bis (methoxymethyl)- (PMN...

  2. 20 CFR 1.4 - Where are other rules concerning OWCP functions found?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Where are other rules concerning OWCP functions found? 1.4 Section 1.4 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR ORGANIZATION AND PROCEDURES PERFORMANCE OF FUNCTIONS § 1.4 Where are other rules concerning...

  3. 20 CFR 1.4 - Where are other rules concerning OWCP functions found?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Where are other rules concerning OWCP functions found? 1.4 Section 1.4 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR ORGANIZATION AND PROCEDURES PERFORMANCE OF FUNCTIONS § 1.4 Where are other rules concerning...

  4. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The...

  5. 10 CFR 960.3-1-4-3 - Site recommendation for characterization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Site recommendation for characterization. 960.3-1-4-3 Section 960.3-1-4-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-3 Site...

  6. 10 CFR 960.3-1-4-3 - Site recommendation for characterization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Site recommendation for characterization. 960.3-1-4-3 Section 960.3-1-4-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-3 Site...

  7. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The...

  8. 10 CFR 960.3-1-4-3 - Site recommendation for characterization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Site recommendation for characterization. 960.3-1-4-3 Section 960.3-1-4-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-3 Site...

  9. 10 CFR 960.3-1-4 - Evidence for siting decisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Evidence for siting decisions. 960.3-1-4 Section 960.3-1-4 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4 Evidence for siting decisions. The...

  10. 10 CFR 960.3-1-4-1 - Site identification as potentially acceptable.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Site identification as potentially acceptable. 960.3-1-4-1 Section 960.3-1-4-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-1 Site identification as potentially acceptable. The...

  11. 10 CFR 960.3-1-4-1 - Site identification as potentially acceptable.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Site identification as potentially acceptable. 960.3-1-4-1 Section 960.3-1-4-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-1 Site identification as potentially acceptable. The...

  12. 10 CFR 960.3-1-4-1 - Site identification as potentially acceptable.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Site identification as potentially acceptable. 960.3-1-4-1 Section 960.3-1-4-1 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Implementation Guidelines § 960.3-1-4-1 Site identification as potentially acceptable. The...

  13. 47 CFR 27.806 - 1.4 GHz service licenses subject to competitive bidding.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false 1.4 GHz service licenses subject to competitive bidding. 27.806 Section 27.806 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.806 1.4 GHz...

  14. 47 CFR 27.806 - 1.4 GHz service licenses subject to competitive bidding.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false 1.4 GHz service licenses subject to competitive bidding. 27.806 Section 27.806 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES 1.4 GHz Band § 27.806 1.4 GHz...

  15. Low energy inner zone protons{emdash}revisited

    SciTech Connect

    Vampola, A.L.

    1996-07-01

    Flux data from a two-element proton telescope flown on the S3-3 satellite in the 1976{endash}1979 time period were averaged to provide a low energy (80 keV to 3.2 MeV) proton model in the inner zone which is more realistic than the AP8 extrapolations. At {ital L}=1.35 and 1.85, S3-3 proton fluxes at 1.5 MeV and alpha particles at 4 MeV agree with published data. In the range {ital L}=1.35 to 1.85, the 1.5 to 3.2 MeV proton channel fluxes on S3-3 also agree with the AP8 model. But in this {ital L} range at 80 keV to 1.5 MeV, the S3-3 proton telescope measured higher fluxes than are present in the AP8 model. The discrepancy is maximum in the {ital L}=1.35 to 1.45 range and increases at lower energies, with the maximum discrepancy being three orders of magnitude in the 80 to 150 keV range at {ital L}=1.4. A model to supplement AP8 has been developed covering the energy range 80 keV to 3.2 MeV over the {ital L} range of 1.2 to 2.4. {copyright} {ital 1996 American Institute of Physics.}

  16. Differential Cross Sections for Proton-Proton Elastic Scattering

    NASA Technical Reports Server (NTRS)

    Norman, Ryan B.; Dick, Frank; Norbury, John W.; Blattnig, Steve R.

    2009-01-01

    Proton-proton elastic scattering is investigated within the framework of the one pion exchange model in an attempt to model nucleon-nucleon interactions spanning the large range of energies important to cosmic ray shielding. A quantum field theoretic calculation is used to compute both differential and total cross sections. A scalar theory is then presented and compared to the one pion exchange model. The theoretical cross sections are compared to proton-proton scattering data to determine the validity of the models.

  17. Structural investigation of protonated azidothymidine and protonated dimer.

    PubMed

    Ziegler, Blake E; Marta, Rick A; Burt, Michael B; Martens, Sabrina M; Martens, Jonathan K; McMahon, Terry B

    2014-02-01

    Infrared multiple photon dissociation (IRMPD) spectroscopy experiments and quantum chemical calculations have been used to explore the possible structures of protonated azidothymidine and the corresponding protonated dimer. Many interesting differences between the protonated and neutral forms of azidothymidine were found, particularly associated with keto-enol tautomerization. Comparison of computational vibrational and the experimental IMRPD spectra show good agreement and give confidence that the dominant protonated species has been identified. The protonated dimer of azidothymidine exhibits three intramolecular hydrogen bonds. The IRMPD spectrum of the protonated dimer is consistent with the spectrum of the most stable computational structure. This work brings to light interesting keto-enol tautomerization and exocyclic hydrogen bonding involving azidothymidine and its protonated dimer. The fact that one dominant protonated species is observed in the gas phase, despite both the keto and enol structures being similar in energy, is proposed to be the direct result of the electrospray ionization process in which the dominant protonated dimer structure dissociates in the most energetically favorable way. PMID:24306778

  18. 2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores.

    PubMed

    Oldershaw, K A; Taylor, C W

    1990-11-12

    In permeabilized rat hepatocytes a maximal concentration (25 microM) of 2,5-di-(tert-butyl)-1,4-benzohydroquineone (tBuBHQ) mobilized 70% of sequestere Ca2+ and a half-maximal effect was produced by 1.7 microM tBuBHQ. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) stimulated release of about 40% of the intracellular Ca2+ stores. Combined applications of a range of tBuBHQ concentrations with a maximal concentration of Ins(1,4,5)P3 demonstrated that tBuBHQ has slight selectivity for the Ca2+ transport process of the Ins(1,4,5)P3-sensitive stores. We conclude that the Ins(1,4,5)P3-sensitive stores are a subset of those sensitive to tBuBHQ and that the latter is therefore unlikely to prove useful as a tool to discriminate Ins(1,4,5)P3-sensitive and -insensitive Ca2+ stores though it may provide opportunities to design more selective agents. PMID:2253774

  19. Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons

    PubMed Central

    Goodwin, Amy K.; Kaminski, Barbara J.; Weerts, Elise M.

    2012-01-01

    Rationale Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are gamma-hydroxybutyrate (GHB) pro-drugs and drugs of abuse. Objective Given the reports of abuse, and the ease at which GBL and 1,4-BD may be obtained, we investigated the reinforcing of GBL (n=5) and 1,4-BD (n=4) in baboons using IV self-administration procedures. Methods Sessions ran 24 h/day. Each injection was contingent upon completion of a fixed number (120 or 160) of lever responses. A 3-h timeout period followed each injection, limiting the total number of injections to 8/day. Self-administration was first established with cocaine (0.32 mg/kg/injection). GBL (10–130.0 mg/kg/injection), 1,4-BD (10–100 mg/kg/injection) or vehicle were substituted for cocaine at least 15 days. Food pellets were available ad libitum 24 h/day and were contingent upon completion of 10 lever responses. Results GBL (32–100 mg/kg/injection) maintained significantly greater numbers of injections when compared to vehicle in 4 of 5 baboons and mean rates of injection were high (>6 per day) in 3 baboons and moderate in the fourth baboon (4–6 per day). 1,4-BD (78–130 mg/kg/injection) maintained significantly greater numbers of injections when compared to vehicle in only 2 out of 4 baboons and rates were moderate to high in both baboons. Self-injection of these doses of GBL and 1,4-BD generally inhibited food-maintained responding. Conclusions GBL and 1,4-BD have abuse liability. Given that GBL and 1,4-BD are self-administered, are easier to obtain than GHB, and are detected in seized samples, additional legal control measures of these GHB pro-drugs may be needed. PMID:22945514

  20. Time-Domain MW Spectroscopy: Fundamental Physics from Molecular Rotation

    NASA Astrophysics Data System (ADS)

    Grabow, Jens-Uwe

    2011-06-01

    In the past, it was a great triumph of Dirac's theory to predict the fine structure in the energy levels of the simplest atom. Nevertheless, even the relativistic Dirac theory did not completely describe the spectrum of the electron in an H-atom. However, at that time, attempts to obtain accurate information through a study of the Balmer lines have been frustrated by the large Doppler width in comparison to the small shifts. Obtaining more accurate information was the key to provide a delicate test of the relativistic wave equation as well as finding confirmation for line shifts due to coupling of the atom with the radiation field and any non-Coulombic interaction. Then, the advances in microwave (MW) techniques resulted in new physical tools, making it possible to observe the small energy difference of terms that were degenerate in Dirac's theory. This, as well as the small deviation of the electron's gyromagnetic ratio g_e from the value 2, provided an excellent test for the validity of quantum electrodynamics (QED). At present, the electron electric dipole moment (e-EDM) is a particularly good place to find, as proposed by Purcell and Ramsey, a new source for P and T violation that may, in fact, be linked to the matter-antimatter asymmetry of our Universe and - in a wider sense - be responsible for our existence. Since the Standart Modell's (SM) prediction is negligible, any observed d_e ≠ 0 is direct evidence for "New Physics" beyond the SM. Many supersymmetric theories in extension to the SM, indeed, predict an e-EDM within two orders of magnitude from the current limit |d_e| < 1.6 × 10-27 e \\cdot cm. However, this limit was published already in 2002, nine years ago. Since then, no progress was made. As at the time when Dirac's equation was put to test, attempts to obtain accurate information through a spectroscopic study are mostly frustrated by the large Doppler width in comparison to the small shifts. Again, obtaining more accurate information will

  1. Alstom 3-MW Wind Turbine Installed at NWTC (Fact Sheet)

    SciTech Connect

    Not Available

    2011-09-01

    The 3-MW Alstom wind turbine was installed at NREL's NWTC in October 2010. Test data will be used to validate advanced turbine design and analysis tools. NREL signed a Cooperative Research and Development Agreement with Alstom in 2010 to conduct certification testing on the company's 3-MW ECO 100 wind turbine and to validate models of Alstom's unique drivetrain concept. The turbine was installed at NREL's National Wind Technology Center (NWTC) in October 2010 and engineers began certification testing in 2011. Tests to be conducted by NREL include a power quality test to finalize the International Electrotechnical Commission (IEC) requirements for type certification of the 60-Hz unit. The successful outcome of this test will enable Alstom to begin commercial production of ECO 100 in the United States. NREL also will obtain additional measurements of power performance, acoustic noise, and system frequency to complement the 50 Hz results previously completed in Europe. After NREL completes the certification testing on the ECO 100, it will conduct long-term testing to validate gearbox performance to gain a better understanding of the machine's unique ALSTOM PURE TORQUE{trademark} drivetrain concept. In conventional wind turbines, the rotor is supported by the shaft-bearing gearbox assembly. Rotor loads are partially transmitted to the gearbox and may reduce gearbox reliability. In the ALSTOM PURE TORQUE concept, the rotor is supported by a cast frame running through the hub, which transfers bending loads directly to the tower. Torque is transmitted to the shaft through an elastic coupling at the front of the hub. According to Alstom, this system will increase wind turbine reliability and reduce operation and maintenance costs by isolating the gearbox from rotor loads. Gearbox reliability has challenged the wind energy industry for more than two decades. Gearbox failures require expensive and time-consuming replacement, significantly increasing the cost of wind plant

  2. Proton decay and nuclear dynamics

    SciTech Connect

    Alvioli, M.; Strikman, M.; Benhar, O.; Ericson, M.

    2010-04-15

    The kinematics of the decay of a bound proton is governed by the proton spectral function. We evaluate this quantity in {sup 16}O using the information from nuclear physics experiments. It also includes a correlated part. The reliability of this evaluation is sufficient to open the possibility of correlated cuts in the missing mass and momentum variables to identify the decay events from the bound protons with a possible increase of the signal-to-noise ratio.

  3. Methoxylation of Singly Bonded 1,4-1',4'-BnC60-C60Bn Dimer: Preferential Formation of 1,4-C60 Adduct with Sterically Less Demanding Addends and Stability Difference between 1,2- and 1,4-OMe(Bn)C60.

    PubMed

    He, Fa-Gui; Li, Zong-Jun; Gao, Xiang

    2016-08-01

    Methoxylation of the singly bonded 1,4-1',4'-BnC60-C60Bn dimer afforded 1,4-OMe(Bn)C60, a 1,4-C60 adduct with sterically less demanding addends, as the major adduct. The situation was different from that of direct functionalization of C60, where 1,2-OMe(Bn)C60 was obtained as the major product. The reaction was studied with in situ vis-NIR spectroscopy and computational calculations to obtain a better understanding of this unusual regioselectivity. The stability difference between 1,2- and 1,4-OMe(Bn)C60 was studied. PMID:27387300

  4. Proton irradiation and endometriosis

    SciTech Connect

    Wood, D.H.; Yochmowitz, M.G.; Salmon, Y.L.; Eason, R.L.; Boster, R.A.

    1983-08-01

    Female rhesus monkeys given single total-body exposures of protons of varying energies developed endometriosis at a frequency significantly higher than that of nonirradiated animals of the same age. The minimum latency period was 7 years after exposure. The doses and energies of the radiation received were within the range that could be received by an aircrew member in near-earth orbit during a random solar flare event, leading to the conclusion that endometriosis should be a consideration in assessing the risk of delayed radiation effects in female crewmembers.

  5. Spin of the proton

    SciTech Connect

    Nathan Isgur

    1996-12-01

    The author argues that their response to the spin crisis should not be to abandon the naive quark model baby, but rather to allow it to mature. In particular, he advocates dressing the baby in qq pairs, first showing that this can be done without compromising the naive quark model's success with either spectroscopy or the OZI rule. Finally, he shows that despite their near invisibility elsewhere, pairs do play an important role in the proton's spin structure by creating an antipolarized qq sea. In the context of an explicit calculation he demonstrates that it is plausible that the entire ''spin crisis'' arises from this effect.

  6. Plant proton pumps.

    PubMed

    Gaxiola, Roberto A; Palmgren, Michael G; Schumacher, Karin

    2007-05-25

    Chemiosmotic circuits of plant cells are driven by proton (H(+)) gradients that mediate secondary active transport of compounds across plasma and endosomal membranes. Furthermore, regulation of endosomal acidification is critical for endocytic and secretory pathways. For plants to react to their constantly changing environments and at the same time maintain optimal metabolic conditions, the expression, activity and interplay of the pumps generating these H(+) gradients have to be tightly regulated. In this review, we will highlight results on the regulation, localization and physiological roles of these H(+)- pumps, namely the plasma membrane H(+)-ATPase, the vacuolar H(+)-ATPase and the vacuolar H(+)-PPase. PMID:17412324

  7. Proton Upset Monte Carlo Simulation

    NASA Technical Reports Server (NTRS)

    O'Neill, Patrick M.; Kouba, Coy K.; Foster, Charles C.

    2009-01-01

    The Proton Upset Monte Carlo Simulation (PROPSET) program calculates the frequency of on-orbit upsets in computer chips (for given orbits such as Low Earth Orbit, Lunar Orbit, and the like) from proton bombardment based on the results of heavy ion testing alone. The software simulates the bombardment of modern microelectronic components (computer chips) with high-energy (.200 MeV) protons. The nuclear interaction of the proton with the silicon of the chip is modeled and nuclear fragments from this interaction are tracked using Monte Carlo techniques to produce statistically accurate predictions.

  8. INJECTOR PARTICLE SIMULATION AND BEAM TRANSPORT IN A COMPACT LINEAR PROTON ACCELERATOR

    SciTech Connect

    Blackfield, D T; Chen, Y J; Harris, J; Nelson, S; Paul, A; Poole, B

    2007-06-18

    A compact Dielectric Wall Accelerator (DWA), with field gradient up to 100 MW/m is being developed to accelerate proton bunches for use in cancer therapy treatment. The injector must create a proton pulse up to several hundred picoseconds, which is then shaped and accelerated with energies up to 250 MeV. The Particle-In-Cell (PIC) code LSP is used to model several aspects of this design. First, we use LSP to obtain the voltage waveform in the A-K gap that will produce a proton bunch with the requisite charge. We then model pulse compression and shaping in the section between the A-K gap and the DWA. We finally use LSP to model the beam transport through the DWA.

  9. Design and testing of a 320 MW pulsed power supply

    SciTech Connect

    Schillig, J.B.; Boenig, H.J.; Ferner, J.A.

    1998-03-01

    For a 60 Tesla, 100 millisecond long pulse magnet five 64 MW (87.6 MVA) power converter modules have been installed. Each module provides a no-load voltage of 4.18 kV and a full load voltage of 3.20 kV at the rated current of 20 kA. The modules are connected to a 1,430 MVA/650 MJ inertial energy storage generator set, which is operated at 21 kV and frequencies between 60 and 42 Hz. They are designed to provide the rated power output for 2 seconds once every hour. Each module consists of two 21 kV/3.1 kV cast coil transformers and two 6-pulse rectifiers connected in parallel without an interphase reactor, forming a 12-pulse converter module. As far as possible standard high power industrial converter components were used, operated closer to their allowable limits. The converters are controlled by three programmable high speed controllers. In this paper the design of the pulsed converters, including control and special considerations for protection schemes with the converters supplying a mutually coupled magnet system, is detailed. Test results of the converters driving an ohmic-inductive load for 2 seconds at 20 kA and 3.2 kV are presented.

  10. Development of a 50 MW Multiple Beam Klystron

    SciTech Connect

    Ives, R Lawrence; Ferguson, Patrick; Read, Michael; Collins, George

    2007-10-31

    The goal of this program was to develop a 50 MW, multiple beam klystron at 11.424 GHz. The device uses eight electron guns and beam lines to achieve the required power level at a beam voltage of 190 kV, consistent with solid state power supplies. The electron gun operates with confined flow focusing, which is unique among current multiple beam sources, and allows operation at power levels consistent with producing 10s of MWs of pulsed RF power. The circuit consists of a ring resonator input cavity, eight sets of buncher cavities, and a ring resonator output cavity. The RF output power is coupled into four rectangular waveguides equally spaced around the klystron. Eight individual collectors absorb the spent beam power in each beam. The klystron operates in a solenoid. The principle challenges in the design included development of the beam optics using confined flow focusing, shaping of the magnetic field in the gun region to avoid beam spiraling, coupling input power equally to all eight beam lines from a single input, and obtaining the required frequency and Q in the output cavity. The mechanical design was particularly complex due to the large parts count, number of braze and weld joints, and close proximity of the beam lines that limited access. Addressing vacuum leaks and cold testing the complex structures was particularly troublesome. At the conclusion of the program, the klystron is experiencing several vacuum leaks that are under repair. Efforts will continue to seal and test the klystron.

  11. Fuel strategy for 2 MW SF-TMSR

    SciTech Connect

    Zhu, Zhiyong; Lin, Jun; Cao, Changqing; Zhang, Haiqing; Zhu, Tianbao; Li, Xiaoyun

    2013-07-01

    China has launched a series of projects for developing high performance nuclear energy systems. The 2 MW solid fuel thorium based molten salt reactor (TMSR-SF) is one of these projects, which uses TRISO fuel elements as the fuel carrier and the FLiBe molten salt (2LiF-BeF{sub 2}) as the coolant. TRISO fuel elements have been well developed in respect to manufacturing, testing experiments inside and outside reactors as well as their successful application in HTGRs. The application of LEU (low enriched uranium) spherical TRISO fuel elements in TMSR-SF can be safely conducted through careful control of temperature and power density. Although the soaking of molten salt into graphite has shown no damage to the graphite material as experienced by ORNL group in the sixties last century, the compatibility of FLiBe salt with graphite covering of the fuel elements should be tested before the application. It is expected that TMSR-SF can be an appropriate test reactor for high performance fuel element development. (authors)

  12. Development of a 10 MW, 91 GHz Gyroklystron

    NASA Astrophysics Data System (ADS)

    Ives, R. Lawrence; Lawson, Wesley; Neilson, Jeff; Read, Michael; Mizuhara, Max; Hogan, Bart; Marsden, David; Robinson, Tom

    2002-12-01

    A 10 MW gyroklystron is being developed for W-Band accelerator research by Calabazas Creek Research, Inc. through a grant from the U.S. Department of Energy. The device will operate at 91.386 GHz and be tested at Stanford Linear Accelerator Center. The gyroklystron will operate at 500 kV and produce 1.5 microsecond pulses at a 120 Hz repetition rate. Predicted gain and efficiency are 56 dB and 36%, respectively. The circuit consists of six cavities, two operating in the fundamental TE01 mode and the remaining four at the second harmonic TE02 mode. The output is converted to a combination of modes that allow propagation across a 1 cm gap between the body and collector, allowing depressed collector operation. The mode combination also allows implementation of a right angle mirror to redirect the output power into a vertical window and protect the window ceramic from electron impact. The gyroklystron is currently being constructed for initial testing. Progress to date is reported.

  13. Exergy analysis and simulation of a 30MW cogeneration cycle

    NASA Astrophysics Data System (ADS)

    Dev, Nikhil; Samsher; Kachhwaha, S. S.; Attri, Rajesh

    2013-06-01

    Cogeneration cycle is an efficient mean to recover the waste heat from the flue gases coming out of gas turbine. With the help of computer simulation, design parameters may be selected for the best performance of cogeneration cycle. In the present work a program is executed in software EES on the basis of mathematical modelling described in paper to study cogeneration cycle performance for different parameters. Results obtained are compared with the results available in literature and are found in good agreement with them. Real gas and water properties are inbuilt in the software. Results show that enthalpy of air entering the combustion chamber is higher than that of the flue gases at combustion chamber outlet. For different operative conditions, energy and exergy efficiencies follow similar trends; although, exergy efficiency values are always lower than the corresponding energy efficiency ones. From the results it is found that turbine outlet temperature (TIT) of 524°C is uniquely suited to efficient cogeneration cycle because it enables the transfer of heat from exhaust gas to the steam cycle to take place over a minimal temperature difference. This temperature range results in the maximum thermodynamic availability while operating with highest temperature and highest efficiency cogeneration cycle. Effect of cycle pressure ratio (CR), inlet air temperature (IAT) and water pressure at heat recovery steam generator (HRSG) inlet on the 30MW cogeneration cycle is also studied.

  14. NASA Ames Research Center 60 MW Power Supply Modernization

    NASA Technical Reports Server (NTRS)

    Choy, Yuen Ching; Ilinets, Boris V.; Miller, Ted; Nagel, Kirsten (Technical Monitor)

    2001-01-01

    The NASA Ames Research Center 60 MW DC Power Supply was built in 1974 to provide controlled DC power for the Thermophysics Facility Arc Jet Laboratory. The Power Supply has gradually losing reliability due to outdated technology and component life limitation. NASA has decided to upgrade the existing rectifier modules with contemporary high-power electronics and control equipment. NASA plans to complete this project in 2001. This project includes a complete replacement of obsolete thyristor stacks in all six rectifier modules and rectifier bridge control system. High power water-cooled thyristors and freewheeling diodes will be used. The rating of each of the six modules will be 4000 A at 5500 V. The control firing angle signal will be sent from the Facility Control System to six modules via fiberoptic cable. The Power Supply control and monitoring system will include a Master PLC in the Facility building and a Slave PLC in each rectifier module. This system will also monitor each thyristor level in each stack and the auxiliary equipment.

  15. 2.5 Gbps clock data recovery using 1/4th-rate quadricorrelator frequency detector and skew-calibrated multi-phase clock generator

    NASA Astrophysics Data System (ADS)

    Tontisirin, S.; Tielert, R.

    2006-09-01

    A Gb/s clock and data recovery (CDR) circuit using 1/4th-rate digital quadricorrelator frequency detector and skew-calibrated multi-phase voltage-controlled oscillator is presented. With 1/4th-rate clock architecture, the coil-free oscillator can have lower operation frequency providing sufficient low-jitter operation. Moreover, it is an inherent 1-to-4 DEMUX. The skew calibration scheme is applied to reduce phase offset in multi-phase clock generator. The CDR with frequency detector can have small loop bandwidth, wide pull-in range and can operate without the need for a local reference clock. This 1/4th-rate CDR is implemented in standard 0.18 μm CMOS technology. It has an active area of 0.7 mm2 and consumes 100 mW at 1.8 V supply. The CDR has low jitter operation in a wide frequency range from 1-2.25 Gb/s. Measurement of Bit-Error Rate is less than 10-12 for 2.25 Gb/s incoming data 27-1 PRBS, jitter peak-to-peak of 0.7 unit interval (UI) modulation at 10 MHz.

  16. Proton-air and proton-proton cross sections from air shower data

    NASA Technical Reports Server (NTRS)

    Linsley, J.

    1985-01-01

    Data on the fluctuations in depth of maximum development of cosmic ray air showers, corrected for the effects of mixed primary composition and shower development fluctuations, yield values of the inelastic proton-air cross section for laboratory energies in the range 10 to the 8th power to 10 to the 10th power GeV. From these values of proton-air cross section, corresponding values of the proton-proton total cross section are derived by means of Glauber theory and geometrical scaling. The resulting values of proton-proton cross section are inconsistent with a well known 1n(2)s extrapolation of ISR data which is consistent with SPS data; they indicate a less rapid rate of increase in the interval 540 sq root of s 100000 GeV.

  17. A new synthetic route to substituted tetracenes and pentacenes via stereoselective [4+2] cycloadditions of 1,4-dihydro-1,4-epoxynaphthalene and isobenzofuran.

    PubMed

    Eda, Shohei; Eguchi, Fumiaki; Haneda, Hiroshi; Hamura, Toshiyuki

    2015-04-01

    Stereoselective [4+2] cycloadditions of 1,4-dihydro-1,4-epoxynaphthalene and isobenzofuran were described. Among several possibilities, syn-exo and/or anti-endo isomers were selectively produced depending on the substitution pattern of the reactants. Importantly, the syn-exo isomer underwent acid promoted aromatization, affording the corresponding tetracene. These findings enabled us to prepare a substituted pentacene with electron withdrawing groups. PMID:25735234

  18. Berkeley Proton Linear Accelerator

    DOE R&D Accomplishments Database

    Alvarez, L. W.; Bradner, H.; Franck, J.; Gordon, H.; Gow, J. D.; Marshall, L. C.; Oppenheimer, F. F.; Panofsky, W. K. H.; Richman, C.; Woodyard, J. R.

    1953-10-13

    A linear accelerator, which increases the energy of protons from a 4 Mev Van de Graaff injector, to a final energy of 31.5 Mev, has been constructed. The accelerator consists of a cavity 40 feet long and 39 inches in diameter, excited at resonance in a longitudinal electric mode with a radio-frequency power of about 2.2 x 10{sup 6} watts peak at 202.5 mc. Acceleration is made possible by the introduction of 46 axial "drift tubes" into the cavity, which is designed such that the particles traverse the distance between the centers of successive tubes in one cycle of the r.f. power. The protons are longitudinally stable as in the synchrotron, and are stabilized transversely by the action of converging fields produced by focusing grids. The electrical cavity is constructed like an inverted airplane fuselage and is supported in a vacuum tank. Power is supplied by 9 high powered oscillators fed from a pulse generator of the artificial transmission line type.

  19. Proton in SRF Niobium

    NASA Astrophysics Data System (ADS)

    Wallace, John Paul

    2011-03-01

    Hydrogen is a difficult impurity to physically deal with in superconducting radio frequency (SRF) niobium, therefore, its properties in the metals should be well understood to allow the metal's superconducting properties to be optimized for minimum loss in the construction of resonant accelerator cavities. It is known that hydrogen is a paramagnetic impurity in niobium from NMR studies. This paramagnetism and its effect on superconducting properties are important to understand. To that end analytical induction measurements aimed at isolating the magnetic properties of hydrogen in SRF niobium are introduced along with optical reflection spectroscopy which is also sensitive to the presence of hydrogen. From the variety, magnitude and rapid kinetics found in the optical and magnetic properties of niobium contaminated with hydrogen forced a search for an atomic model. This yielded quantum mechanical description that correctly generates the activation energy for diffusion of the proton and its isotopes not only in niobium but the remaining metals for which data is available. This interpretation provides a frame work for understanding the individual and collective behavior of protons in metals.

  20. Proton in SRF Niobium

    SciTech Connect

    Wallace, John Paul

    2011-03-31

    Hydrogen is a difficult impurity to physically deal with in superconducting radio frequency (SRF) niobium, therefore, its properties in the metals should be well understood to allow the metal's superconducting properties to be optimized for minimum loss in the construction of resonant accelerator cavities. It is known that hydrogen is a paramagnetic impurity in niobium from NMR studies. This paramagnetism and its effect on superconducting properties are important to understand. To that end analytical induction measurements aimed at isolating the magnetic properties of hydrogen in SRF niobium are introduced along with optical reflection spectroscopy which is also sensitive to the presence of hydrogen. From the variety, magnitude and rapid kinetics found in the optical and magnetic properties of niobium contaminated with hydrogen forced a search for an atomic model. This yielded quantum mechanical description that correctly generates the activation energy for diffusion of the proton and its isotopes not only in niobium but the remaining metals for which data is available. This interpretation provides a frame work for understanding the individual and collective behavior of protons in metals.

  1. Gradients from GOCE reveal gravity changes before Pisagua Mw = 8.2 and Iquique Mw = 7.7 large megathrust earthquakes

    NASA Astrophysics Data System (ADS)

    Álvarez, Orlando; Nacif, Silvina; Spagnotto, Silvana; Folguera, Andres; Gimenez, Mario; Chlieh, Mohamed; Braitenberg, Carla

    2015-12-01

    Considerable improvements in the measurement of the Earth gravity field from GOCE satellite mission have provided global gravity field models with homogeneous coverage, high precision and good spatial resolution. In particular, the vertical gravity gradient (Tzz), in comparison to the classic Bouguer anomaly, defines more accurately superficial mass heterogeneities. Moreover, the correction of these satellite-derived data from the effect of Earth topographic masses by means of new techniques taking into account the Earth curvature, improves results in regional analyses. In a recent work we found a correlation between Tzz and slip distribution for the 2010 Maule Mw = 8.8 earthquake. In the present work, we derive the vertical gravity gradient from the last GOCE only model, corrected by the topographic effect and also by the sediments on depocenters of the offshore region at the Peru-Chile margin, in order to study a spatial relationship between different lobes of the gravity derived signal and the seismic sources of large megathrust earthquakes. In particular, we analyze this relation for the slip models of the 1996 Mw = 7.7 Nazca, 2001 Mw = 8.4 Arequipa, 2007 Mw = 8.0 Pisco events and for the slip models of the 2014 Mw = 8.2 Pisagua and Mw = 7.7 Iquique earthquakes from Schurr et al. (2014), including the previously analyzed 2010 Mw = 8.8 Maule event. Then we find a good correlation between vertical gravity gradients and main rupture zones, correlation that becomes even stronger as the event magnitude increases. Besides this, a gravity fall in the gravity gradient was noticed over the area of the main slip patches at least for the two years before 2014 Mw = 8.2 Pisagua and Mw = 7.7 Iquique earthquakes. Additionally, we found temporal variations of the gravity field after 2010 Mw = 8.8 Maule event, related to the main patches of the slip distribution, and coseismic deformation. Therefore, we analyzed vertical gravity gradient field variations as an indirect measure

  2. Ground-motion Attenuation Relation from Strong-motion Records of the 2001 Mw 7.7 Bhuj Earthquake Sequence (2001-2006), Gujarat, India

    NASA Astrophysics Data System (ADS)

    Mandal, Prantik; Kumar, N.; Satyamurthy, C.; Raju, I. P.

    2009-03-01

    Predictive relations are developed for peak ground acceleration (PGA) from the engineering seismoscope (SRR) records of the 2001 Mw 7.7 Bhuj earthquake and 239 strong-motion records of 32 significant aftershocks of 3.1 ≤ Mw ≤ 5.6 at epicentral distances of 1 ≤ R ≤ 288 km. We have taken advantage of the recent increase in strong-motion data at close distances to derive new attenuation relation for peak horizontal acceleration in the Kachchh seismic zone, Gujarat. This new analysis uses the Joyner-Boore’s method for a magnitude-independent shape, based on geometrical spreading and anelastic attenuation, for the attenuation curve. The resulting attenuation equation is, eqalign{ ln ({Y}) = -7.9527 + 1.4043 {M}_{{W}} - ln left( {{r}_{{jb}}2 + 19.822} right)^{1/2} - 0.0682 {S} ŗ{for} 3.1 { < M}_{{W}} le 7.7quad quad {std}. {dev}. left(σ right): ± 0.8243, ŗ} where, Y is peak horizontal acceleration in g, Mw is moment magnitude, rjb is the closest distance to the surface projection of the fault rupture in kilometers, and S is a variable taking the values of 0 and 1 according to the local site geology. S is 0 for a rock site, and, S is 1 for a soil site. The relation differs from previous work in the improved reliability of input parameters and large numbers of strong-motion PGA data recorded at short distances (0-50 km) from the source. The relation is in demonstrable agreement with the recorded strong-ground motion data from earthquakes of Mw 3.5, 4.1, 4.5, 5.6, and 7.7. There are insufficient data from the Kachchh region to adequately judge the relation for the magnitude range 5.7 ≤ Mw ≤ 7.7. But, our ground-motion prediction model shows a reasonable correlation with the PGA data of the 29 March, 1999 Chamoli main shock (Mw 6.5), validating our ground-motion attenuation model for an Mw6.5 event. However, our ground-motion prediction shows no correlation with the PGA data of the 10 December, 1967 Koyna main shock (Mw 6.3). Our ground-motion predictions

  3. Development of a dry low-NOx gas turbine combustor for a natural-gas fueled 2MW co-generation system

    SciTech Connect

    Mori, Masaaki; Sato, Hiroshi

    1998-07-01

    A dry low-NOx gas turbine combustor has been developed for natural-gas fueled co-generation systems in the power range of 1--4MW. The combustor. called the Double Swirler Combustor, uses the lean premixed combustion to reduce NOx emission. The combustor is characterized by two staged lean premixed combustion with two coaxial annular burners and a simple fuel control system without the complex variable geometry. Substantially low NOx level has been achieved to meet the strict NOx regulation to co-generation systems in Japan. High combustion efficiency has been obtained for a wide operating range. In 1994, Tokyo Gas and Ishikawajima-Harima Heavy Industries initiated a collaborative program to develop a natural-gas fueled low NOx gas turbine engine for new 2MW class co-generation system, named IM270. The Double Swirler Combustor, originally developed by Tokyo Gas, was introduced into the natural gas fueled version of the IM270. Engine test of the first production unit was successfully conducted to confirm substantially low NOx level of less than 15 ppm (O{sub 2} = 16%) with the output power of more than 2MW. Test for the durability and the reliability of the system is being conducted at Tokyo Gas Negishi LNG Terminal in Kanagawa, Japan and successful results have been so far obtained.

  4. Electronic excitations of 1,4-disilyl-substituted 1,4-disilabicycloalkanes: a MS-CASPT2 study of the influence of cage size.

    PubMed

    Sandström, Niclas; Piqueras, Mari Carmen; Ottosson, Henrik; Crespo, Raül

    2007-04-12

    We present a multistate complete active space second-order perturbation theory computational study aimed to predict the low-lying electronic excitations of four compounds that can be viewed as two disilane units connected through alkane bridges in a bicyclic cage. The analysis has focused on 1,4-disilyl-1,4-disilabicyclo[2.2.1]heptane (1a), 1,4-bis(trimethylsilyl)-1,4-disilabicyclo[2.2.1]heptane (1b), 1,4-disilyl-1,4-disilabicyclo[2.1.1]hexane (2a), and 1,4-bis(trimethylsilyl)-1,4-disilabicyclo[2.1.1]hexane (2b). The aim has been to find out the nature of the lowest excitations with significant oscillator strengths and to investigate how the cage size affects the excitation energies and the strengths of the transitions. Two different substituents on the terminal silicon atoms (H and CH3) were used in order to investigate the end group effects. The calculations show that the lowest allowed excitations are of the same character as that found in disilanes but now red-shifted. As the cage size is reduced from a 1,4-disilabicyclo[2.2.1]heptane to a 1,4-disilabicyclo[2.1.1]hexane, the Si...Si through-space distance decreases from approximately 2.70 to 2.50 A and the lowest allowed transitions are red-shifted by up to 0.9 eV, indicating increased interaction between the two Si-Si bonds. The first ionization potential, which corresponds to ionization from the Si-Si sigma orbitals, is lower in 1b and 2b than in Si2Me6 by approximately 0.9 and 1.2 eV, respectively. Moreover, 1b and 2b, which have methyl substituents at the terminal Si atoms, have slightly lower excitation energies than the analogous species 1a and 2a. PMID:17388376

  5. Grid Simulator for Testing MW-Scale Wind Turbines at NREL (Poster)

    SciTech Connect

    Gevorgian, V.; McDade, M.; Wallen, R.; Mendoza, I.; Shirazi, M.

    2011-05-01

    As described, an initiative by NREL to design and construct a 9-MVA grid simulator to operate with the existing 2.5 MW and new upcoming 5-MW dynamometer facilities will fulfill this role and bring many potential benefits to the U.S. wind industry with the ultimate goal of reducing wind energy integration costs.

  6. Cloning and expression analysis of cysteine protease gene (MwCP) in Agropyron mongolicum Keng.

    PubMed

    Ao, T G B Y; Lang, M L; Li, Y Q; Zhao, Y; Wang, L C; Yang, X J

    2016-01-01

    In this study, a cysteine protease gene (MwCP) from Agropyron mongolicum Keng was isolated using RACE. Sequence analysis indicated that MwCP was 1473 bp, and it contained a 1134-bp open reading frame, which encoded 377 amino acids with a 24-amino acid N-terminal signal peptide. The results indicated that the MwCP protein was a new member of the papain C1A family, and it was predicted to be an extracellular, secretory stable hydrophilic protein. The secondary structure of MwCP was mainly composed of α-helices and random coils, and the space structure primarily contained α-helices, β-sheets, and β-turns. Homology analyses showed the 98% homology between MwCP amino acids and a cysteine protease found in Triticum aestivum (GenBank accession No. AAW21813.1). Analysis of mRNA using semi-quantitative RT-PCR indicated that during a 48-h drought stress period, MwCP was expressed during the 4th hour, and the expression level peaked during the 6th hour before declining to the original level. The results revealed that MwCP was involved in drought-resistant physiological processes of A. mongolicum. Moreover, the MwCP expression levels were highest in leaves, intermediate in roots, and lowest in stems. PMID:26909915

  7. Bioenergetics: Proton fronts on membranes

    NASA Astrophysics Data System (ADS)

    Agmon, Noam; Gutman, Menachem

    2011-11-01

    Proton migration on membranes is a crucial step in the bioenergetics of the cell. It has typically been regarded as slow successive proton transfers between ionizable moieties within the membrane, but recent measurements suggest fast lateral diffusion in the membrane's hydration layer.

  8. Proton Collimators for Fusion Reactors

    NASA Technical Reports Server (NTRS)

    Miley, George H.; Momota, Hiromu

    2003-01-01

    Proton collimators have been proposed for incorporation into inertial-electrostatic-confinement (IEC) fusion reactors. Such reactors have been envisioned as thrusters and sources of electric power for spacecraft and as sources of energetic protons in commercial ion-beam applications.

  9. The Indian Proton Driver Project

    NASA Astrophysics Data System (ADS)

    Krishnagopal, Srinivas

    2005-06-01

    There are two new proton accelerator projects being considered in India. One is a 20 MeV, 30 mA, front end of a proton linac driver for nuclear transmutation applications. The second is a 1 GeV, 100 kW rapid cycling synchrotron for a spallation neutron source. We present the current design status of both these projects.

  10. High Dust Depletion in two Intervening Quasar Absorption Line Systems with the 2175 Å Extinction Bump at z ~ 1.4

    NASA Astrophysics Data System (ADS)

    Jiang, Peng; Ge, Jian; Prochaska, J. Xavier; Wang, Junfeng; Zhou, Hongyan; Wang, Tinggui

    2010-12-01

    We present the column densities of heavy elements and dust depletion studies in two strong Mg II absorption systems at z ~ 1.4 displaying the 2175 Å dust extinction feature. Column densities are measured from low-ionization absorption lines using an Apparent Optical Depth Method on the Keck/ESI spectra. We find that the dust depletion patterns resemble that of cold diffuse clouds in the Milky Way (MW). The values, [Fe/Zn] ≈-1.5 and [Si/Zn]<-0.67, are among the highest dust depletion measured for quasar absorption line systems. In another 2175 Å absorber at z = 1.64 toward the quasar SDSS J160457.50+220300.5, Noterdaeme et al. reported a similar dust depletion measurement ([Fe/Zn] = -1.47 and [Si/Zn] = -1.07) and detected C I and CO absorption lines on its VLT/UVES spectrum. We conclude that heavy dust depletion (i.e., a characteristic of cold dense clouds in MW) is required to produce a pronounced 2175 Å extinction bump. The data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation.

  11. Investigation of continuous wave and pulsed laser performance based on Nd3+:Gd0.6Y1.4SiO5 crystal

    NASA Astrophysics Data System (ADS)

    Feng, Chao; Liu, Zhaojun; Cong, Zhenhua; Shen, Hongbin; Li, Yongfu; Wang, Qingpu; Fang, Jiaxiong; Xu, Xiaodong; Xu, Jun; Zhang, Xingyu

    2015-12-01

    We systematically investigated a laser diode (LD) pumped Nd:GYSO (Nd3+:Gd0.6Y1.4SiO5) laser. The output power of the continuous wave laser was as high as 3.5 W with a slope efficiency of 31.8%. In the Q-switched operation; the laser exhibited dual-wavelengths output (1073.6 nm and 1074.7 nm) synchronously with a Cr4+:YAG as the saturable absorber (SA). Additionally, a passively mode-locked laser was demonstrated using a semiconductor SA mirror with a maximum average output power of 510 mW at a central wavelength of 1074 nm, while the pulse width of the laser was as short as 5 ps. Our experiment proved that the Nd:GYSO mixed crystal was a promising material for a solid-state laser.

  12. Proton therapy for pancreatic cancer

    PubMed Central

    Nichols, Romaine C; Huh, Soon; Li, Zuofeng; Rutenberg, Michael

    2015-01-01

    Radiotherapy is commonly offered to patients with pancreatic malignancies although its ultimate utility is compromised since the pancreas is surrounded by exquisitely radiosensitive normal tissues, such as the duodenum, stomach, jejunum, liver, and kidneys. Proton radiotherapy can be used to create dose distributions that conform to tumor targets with significant normal tissue sparing. Because of this, protons appear to represent a superior modality for radiotherapy delivery to patients with unresectable tumors and those receiving postoperative radiotherapy. A particularly exciting opportunity for protons also exists for patients with resectable and marginally resectable disease. In this paper, we review the current literature on proton therapy for pancreatic cancer and discuss scenarios wherein the improvement in the therapeutic index with protons may have the potential to change the management paradigm for this malignancy. PMID:26380057

  13. Proton Affinity of Isomeric Dipeptides Containing Lysine and Non-Proteinogenic Lysine Homologues.

    PubMed

    Batoon, Patrick; Ren, Jianhua

    2016-08-18

    Conformational effects on the proton affinity of oligopeptides have been studied using six alanine (A)-based acetylated dipeptides containing a basic probe that is placed closest to either the C- or the N-terminus. The basic probe includes Lysine (Lys) and two nonproteinogenic Lys-homologues, ornithine (Orn) and 2,3-diaminopropionic acid (Dap). The proton affinities of the peptides have been determined using the extended Cooks kinetic method in a triple quadrupole mass spectrometer. Computational studies have been carried out to search for the lowest energy conformers and to calculate theoretical proton affinities as well as various molecular properties using the density functional theory. The dipeptides containing a C-terminal probe, ALys, AOrn, and ADap, were determined to have a higher proton affinity by 1-4 kcal/mol than the corresponding dipeptides containing an N-terminal probe, LysA, OrnA, and DapA. For either the C-probe peptides or the N-probe peptides, the proton affinity reduces systematically as the side-chain of the probe residue is shortened. The difference in the proton affinities between isomeric peptides is largely associated with the variation of the conformations. The peptides with higher values of the proton affinity adopt a relatively compact conformation such that the protonated peptides can be stabilized through more efficient internal solvation. PMID:27459294

  14. Regiospecific protonation of organic chromophores.

    PubMed

    Tang, Tao; Lin, Tingting; Wang, FuKe; He, Chaobin

    2016-07-28

    Highly conductive, acid doped polymers such as PEDOT/PSS and polyaniline (PANI) have attracted much attention due to their potential applications in flexible electronics. However, the understanding of the mechanism behind the doping process is still lacking. In this paper, we conduct a systematic and detailed investigation on the acid doping behaviors of four model compounds which were synthesized by combining different protonatable units such as pyridal[2,1,3]thiadiazole (PT), benzo[2,1,3]thiadiazole (BT), cyclopentadithiophene (CPDT), and azulene. DFT simulation and UV-vis-NIR spectral studies show that while the site of first protonation was mainly determined by proton affinity, the subsequent site of protonation and doping density were determined by the nature of the first protonation and influenced by the following two factors: (1) electrostatic charge repulsion and (2) the possible delocalization of protonated charge in the conjugated structure. If the first protonation occurs at heteroatoms and results in a coplanar structure, the subsequent sites of protonation are mainly determined by the distance from the positive charge center to lower the effect of static repulsion and charge delocalization. On the other hand, if the first protonation occurs on the main chain carbon atoms which induce a large torsional angle (non-coplanar) as the carbon hybridization changes from sp(2) to sp(3), the conformation and the possible charge delocalization in the protonated molecules will play an important role in determining the subsequent protonation. Our study provides new insight into the acid-doping mechanism of conductive polymers, which could be used as a guide to design new acid doped highly conductive polymers. PMID:27346384

  15. Ion-proton pulsars

    NASA Astrophysics Data System (ADS)

    Jones, P. B.

    2016-07-01

    Evidence derived with minimal assumptions from existing published observations is presented to show that an ion-proton plasma is the source of radio-frequency emission in millisecond and in normal isolated pulsars. There is no primary involvement of electron-positron pairs. This conclusion has also been reached by studies of the plasma composition based on well-established particle-physics processes in neutron stars with positive polar-cap corotational charge density. This work has been published in a series of papers which are also summarized here. It is now confirmed by simple analyses of the observed radio-frequency characteristics, and its implications for the further study of neutron stars are outlined.

  16. Ion-proton pulsars

    NASA Astrophysics Data System (ADS)

    Jones, P. B.

    2016-04-01

    Evidence derived with minimal assumptions from existing published observations is presented to show that an ion-proton plasma is the source of radio-frequency emission in millisecond and in normal isolated pulsars. There is no primary involvement of electron-positron pairs. This conclusion has also been reached by studies of the plasma composition based on well-established particle-physics processes in neutron stars with positive polar-cap corotational charge density. This work has been published in a series of papers which are also summarized here. It is now confirmed by simple analyses of the observed radio-frequency characteristics, and its implications for the further study of neutron stars are outlined.

  17. 49 CFR 173.65 - Exceptions for Division 1.4G consumer fireworks.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Exceptions for Division 1.4G consumer fireworks... Class 1 § 173.65 Exceptions for Division 1.4G consumer fireworks. (a) Notwithstanding the requirements of §§ 173.56(b), 173.56(f), 173.56(i), and 173.64, Division 1.4G consumer fireworks may be...

  18. 49 CFR 173.65 - Exceptions for Division 1.4G consumer fireworks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Exceptions for Division 1.4G consumer fireworks... Class 1 § 173.65 Exceptions for Division 1.4G consumer fireworks. (a) Notwithstanding the requirements of §§ 173.56(b), 173.56(f), 173.56(i), and 173.64, Division 1.4G consumer fireworks may be...

  19. Electrochemical selenium- and iodonium-initiated cyclisation of hydroxy-functionalised 1,4-dienes

    PubMed Central

    Röse, Philipp; Emge, Steffen; Yoshida, Jun-ichi

    2015-01-01

    Summary The cobalt(I)-catalysed 1,4-hydrovinylation reaction of allyloxytrimethylsilane and allyl alcohol with substituted 1,3-dienes leads to hydroxy-functionalised 1,4-dienes in excellent regio- and diastereoselective fashion. Those 1,4-dienols can be converted into tetrahydrofuran and pyran derivatives under indirect electrochemical conditions generating selenium or iodonium cations. The reactions proceed in good yields and regioselectivities for the formation of single diastereomers. PMID:25815067

  20. 25 CFR 1.4 - State and local regulation of the use of Indian property.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false State and local regulation of the use of Indian property. 1.4 Section 1.4 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR PROCEDURES AND PRACTICE APPLICABILITY OF RULES OF THE BUREAU OF INDIAN AFFAIRS § 1.4 State and local regulation of the use of Indian property. (a) Except as provided...

  1. 36 CFR 1.4 - What terms do I need to know?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false What terms do I need to know? 1.4 Section 1.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS § 1.4 What terms do I need to know? (a) The following definitions shall apply to this chapter, unless modified by...

  2. Spectral variability in the X-ray pulsar GX 1+4

    NASA Technical Reports Server (NTRS)

    Becker, R. H.; Boldt, E. A.; Holt, S. S.; Pravdo, S. H.; Rothschild, R. E.; Serlemitsos, P. J.; Swank, J. H.

    1976-01-01

    Observations of the galactic center region, hard X-ray source GX 1+4 by the GSFC X-ray spectroscopy experiment on OSO-8 confirm that GX 1+4 is a slow X-ray pulsar. The amount of absorption by cold matter in the spectrum of GX 1+4 varies significantly within a 24 hour period, behavior typical of many X-ray binary systems. The light curve for the pulsations from GX 1+4 appears to be energy dependent.

  3. Biodegradation of 1,4-dioxane: effects of enzyme inducers and trichloroethylene.

    PubMed

    Hand, Steven; Wang, Baixin; Chu, Kung-Hui

    2015-07-01

    1,4-Dioxane is a groundwater contaminant and probable human carcinogen. In this study, two well-studied degradative bacteria Mycobacterium vaccae JOB5 and Rhodococcus jostii RHA1 were examined for their 1,4-dioxane degradation ability in the presence and absence of its co-contaminant, trichloroethylene (TCE), under different oxygenase-expression conditions. These two strains were precultured with R2A broth (complex nutrient medium) before supplementation with propane or 1-butanol to induce the expression of different oxygenases. Both propane- and 1-butanol-induced JOB5 and RHA1 were able to degrade 1,4-dioxane, TCE, and mixtures of 1,4-dioxane/TCE. Complete degradation of 1,4-dioxane/TCE mixture was observed only in propane-induced strain JOB5. Inhibition was observed between 1,4-dioxane and TCE for all cells. Furthermore, product toxicity caused incomplete degradation of 1,4-dioxane by 1-butanol-induced JOB5. In general, the more TCE degraded, the greater extent of product toxicity cells experienced; however, susceptibility to product toxicity was found to be both strain- and inducer-dependent. The findings of this study provide fundamental basis for developing an effective in-situ remediation method for 1,4-dioxane-contaminated ground water and the first known study of 1,4-dioxane degradation by wild-type strain RHA1. PMID:25813968

  4. On some 1/4 BPS Wilson-'t Hooft loops

    NASA Astrophysics Data System (ADS)

    Liu, Chang-Yong; Qin, Li

    2015-10-01

    In this paper, we investigate the 1/4 BPS Wilson-'t Hooft loops in N=4 supersymmetric Yang-Mills theory. We use the bulk D3-brane solutions with both electric and magnetic charges on its world-volume to describe some of 1/4 BPS Wilson-'t Hooft loops. The D3-brane supersymmetric solutions are derived form requiring κ-symmetry. We find the two consistent constraints for Killing spinors and calculate the conserved charges of straight 1/4 BPS Wilson-'t Hooft loops and expectation values of circular 1/4 BPS Wilson-'t Hooft loops separately.

  5. Landscape response to the Mw7.9 Gorkha earthquake

    NASA Astrophysics Data System (ADS)

    Andermann, Christoff; Turowski, Jens; Behling, Robert; Cook, Kristen; Hovius, Niels; Marc, Odin; Roessner, Sigrid; Sens-Schoenfelder, Christoph; Emberson, Robert; Burtin, Arnaud; Dietze, Michael; Adhikari, Basanta; Parajuli, Binod

    2016-04-01

    Strong earthquakes cause transient perturbations of the near Earth's surface system. These include the widespread landsliding and subsequent mass movement and the loading of rivers with sediments. In addition, rock mass is shattered during the event, forming cracks that affect rock strength and hydrological conductivity. Often overlooked in the immediate aftermath of an earthquake, these perturbations can represent a major part of the overall disaster with an impact that can last for years before restoring to background conditions. Thus, the relaxation phase is part of the seismically induced change by an earthquake and need to be monitored in order to understand the full impact of earthquakes on the Earth system. Here, we present first results from the rapid respond earth surface processes monitoring program put in place by several European groups after the Mw7.9 Gorkha earthquake. To monitor the transient effects of the earthquake on the Earth surface system, we have installed a comprehensive network of 13 river sampling locations for daily water and sediment sampling, covering all major rivers draining the earthquake-affected areas immediately after the event. Nested within this regional network, we have installed an array of 16 seismometers and geophones and 6 weather stations in the upper Bhotekoshi catchment, covering an area of ~50 km2. The field measurements are accompanied by repeated mapping of landslide activities and volumes over subsequent seasons using high resolution optical (RapidEye) and radar imagery (TanDEM TerraSAR-X). The combination of all of these data will help when interpreting our field observation in the regional context of catastrophic failure of hillslopes and their link with sediment transport in the rivers. First river gauging observation show a pronounced increase in river discharge in the order of >20% for the respective pre-monsoon season. We interpreted this as a direct impact of the shaking on the valley-ridge scale sub

  6. The 2008 Mw 6.0 Wells, Nevada Earthquake Sequence

    NASA Astrophysics Data System (ADS)

    Smith, K.; Depolo, D.; Torrisi, J.; Edwards, N.; Biasi, G.; Slater, D.

    2008-12-01

    The Mw 6.0 February 21, 2008 (06:16 AM PDT) Wells, Nevada normal faulting earthquake occurred in Town Creek Flat about 8 km northeast of the small community of Wells. A preliminary set of about 1000 aftershock relocations clearly defines a 55-60 degree southeast dipping fault plane. The structure projects to the surface along the southern end of the Snake Range, although no surface offsets have been identified. The earthquake occurred east of the Ruby Mountains and Snake Range west dipping range front faults, possibly on a northern extension of an east dipping normal fault system on the eastern side of the East Humbolt Range. The depth of the mainshock is estimated to be 10.5 km with the aftershock sequence extending to about 15 km. Typical of moderate sized Basin and Range earthquakes, the early aftershock period included several earthquakes of M > 4 and these were felt strongly by the residents of Wells. From the preliminary relocations, the source radius of the mainshock is estimated to be about 4 km, resulting in an estimated displacement of 55 to 83 cm and static stress drop of 72 to 86 bars, depending on the seismic moment estimate used. Aftershock relocations suggest a radial rupture mechanism. Fortunately, the EarthScope USArray network was operating in Nevada at the time of the event and provided unique controls on the mainshock and early aftershock locations. The earthquake occurred in an area of relatively low seismic hazard and the only permanent seismograph in the region was the U.S. National Network broadband station east of the Ruby Mountains south of Wells. The University of Utah and University of Nevada deployed locally recorded strong motion instruments in the Wells area. Also, an 8 station IP telemetered strong motion network, jointly deployed by the U.S. Geological Survey and University of Nevada Reno, provided real-time data for quick high-quality aftershock relocations and ground motion estimates. In addition, the University of Utah

  7. Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD).

    PubMed

    Wood, David M; Brailsford, Alan D; Dargan, Paul I

    2011-01-01

    Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patterns and management of acute toxicity associated with their use; and the clinical patterns of presentation and management of chronic dependency associated with GHB and its analogues. PMID:21548140

  8. Comparative Analyses of Two Thermophilic Enzymes Exhibiting both β-1,4 Mannosidic and β-1,4 Glucosidic Cleavage Activities from Caldanaerobius polysaccharolyticus▿ †

    PubMed Central

    Han, Yejun; Dodd, Dylan; Hespen, Charles W.; Ohene-Adjei, Samuel; Schroeder, Charles M.; Mackie, Roderick I.; Cann, Isaac K. O.

    2010-01-01

    The hydrolysis of polysaccharides containing mannan requires endo-1,4-β-mannanase and 1,4-β-mannosidase activities. In the current report, the biochemical properties of two endo-β-1,4-mannanases (Man5A and Man5B) from Caldanaerobius polysaccharolyticus were studied. Man5A is composed of an N-terminal signal peptide (SP), a catalytic domain, two carbohydrate-binding modules (CBMs), and three surface layer homology (SLH) repeats, whereas Man5B lacks the SP, CBMs, and SLH repeats. To gain insights into how the two glycoside hydrolase family 5 (GH5) enzymes may aid the bacterium in energy acquisition and also the potential application of the two enzymes in the biofuel industry, two derivatives of Man5A (Man5A-TM1 [TM1 stands for truncational mutant 1], which lacks the SP and SLH repeats, and Man5A-TM2, which lacks the SP, CBMs, and SLH repeats) and the wild-type Man5B were biochemically analyzed. The Man5A derivatives displayed endo-1,4-β-mannanase and endo-1,4-β-glucanase activities and hydrolyzed oligosaccharides with a degree of polymerization (DP) of 4 or higher. Man5B exhibited endo-1,4-β-mannanase activity and little endo-1,4-β-glucanase activity; however, this enzyme also exhibited 1,4-β-mannosidase and cellodextrinase activities. Man5A-TM1, compared to either Man5A-TM2 or Man5B, had higher catalytic activity with soluble and insoluble polysaccharides, indicating that the CBMs enhance catalysis of Man5A. Furthermore, Man5A-TM1 acted synergistically with Man5B in the hydrolysis of β-mannan and carboxymethyl cellulose. The versatility of the two enzymes, therefore, makes them a resource for depolymerization of mannan-containing polysaccharides in the biofuel industry. Furthermore, on the basis of the biochemical and genomic data, a molecular mechanism for utilization of mannan-containing nutrients by C. polysaccharolyticus is proposed. PMID:20562312

  9. Development of gyrotrons for fusion with power exceeding 1 MW over a wide frequency range

    NASA Astrophysics Data System (ADS)

    Kariya, T.; Imai, T.; Minami, R.; Numakura, T.; Eguchi, T.; Kato, T.; Endo, Y.; Ichimura, M.; Shimozuma, T.; Kubo, S.; Takahashi, H.; Yoshimura, Y.; Igami, H.; Ito, S.; Mutoh, T.; Sakamoto, K.; Idei, H.; Zushi, H.; Nagasaki, K.; Sano, F.; Ono, M.; Mitsunaka, Y.

    2015-09-01

    Megawatt-class gyrotrons covering a wide frequency range (14 GHz-300 GHz) are in increasing demand for nuclear fusion. Recent electron cyclotron heating and electron cyclotron current drive experiments highlight a requirement of megawatt-scale gyrotrons at a relatively lower frequency (14-35 GHz) range of some plasma devices, like GAMMA 10/PDX of the University of Tsukuba, QUEST of Kyushu University, NSTX-U of Princeton Plasma Physics Laboratory, and Heliotron J of Kyoto University. Collaborative studies for designing a new 28 GHz/35 GHz dual-frequency gyrotron and a 14 GHz gyrotron have commenced. Operation above 1 MW of 28 GHz/35 GHz dual oscillation was demonstrated experimentally. Further in the design of dual-frequency gyrotron, operations with 2 MW 3 s and 0.4 MW CW (continuous wave) at 28 GHz, and power exceeding 1 MW for 3 s at 34.8 GHz have been shown to be feasible. The 14 GHz gyrotron is expected to operate above 1 MW. We are also developing higher frequency gyrotrons (77-300 GHz). The joint program of National Institute for Fusion Science and the University of Tsukuba developed two new 154 GHz gyrotrons for the large helical device after the demonstration of three 77 GHz gyrotrons. The 154 GHz gyrotrons achieved a maximum output power of 1.25 MW and quasi-CW operation of 0.35 MW for 30 min.

  10. Proton diffusion along biological membranes

    NASA Astrophysics Data System (ADS)

    Medvedev, E. S.; Stuchebrukhov, A. A.

    2011-06-01

    Biological surfaces are known to be capable of retaining protons and facilitating their lateral diffusion. Since the surface dynamically exchanges protons with the bulk, the proton movement from a source to a target at the surface acquires a complicated pattern of coupled surface and bulk (2D + 3D) diffusion of which the main feature is that the surface acts as a proton-collecting antenna enhancing the proton flux from the bulk. A phenomenological model of this process is reviewed and its applications to recent experiments on lipid bilayers and small unilaminar vesicles are discussed. The model (i) introduces the important notions of the fast and slow regimes of proton exchange between the surface and the bulk, (ii) permits evaluation of the antenna radius and amplification coefficient in both regimes, (iii) explains the observed macroscopically large distances (in the micrometer range; Antonenko and Pohl 1998 FEBS Lett. 429 197) that the proton can travel along lipid membranes embedded into pure aqueous solutions, and (iv) predicts the dependence of the steady-state proton flux and the kinetics of the non-stationary diffusion upon the buffer concentration in buffered solutions. The surface diffusion coefficient for small unilaminar vesicles is calculated from experimental data (Sandén et al 2010 Proc. Natl Acad. Sci. USA 107 4129) to be 1 × 10 - 5 cm2 s - 1. The dependence of the shape of the kinetic curves representing protonation/deprotonation of a lipid-bound pH-sensitive dye attached to a planar bilayer lipid membrane upon the buffer concentration (Serowy et al 2003 Biophys. J. 84 1031) and the effect of changing the membrane composition (Antonenko and Pohl 2008 Eur. Biophys. J. 37 865) are explained.

  11. Proton diffusion along biological membranes.

    PubMed

    Medvedev, E S; Stuchebrukhov, A A

    2011-06-15

    Biological surfaces are known to be capable of retaining protons and facilitating their lateral diffusion. Since the surface dynamically exchanges protons with the bulk, the proton movement from a source to a target at the surface acquires a complicated pattern of coupled surface and bulk (2D + 3D) diffusion of which the main feature is that the surface acts as a proton-collecting antenna enhancing the proton flux from the bulk. A phenomenological model of this process is reviewed and its applications to recent experiments on lipid bilayers and small unilaminar vesicles are discussed. The model (i) introduces the important notions of the fast and slow regimes of proton exchange between the surface and the bulk, (ii) permits evaluation of the antenna radius and amplification coefficient in both regimes, (iii) explains the observed macroscopically large distances (in the micrometer range; Antonenko and Pohl 1998 FEBS Lett. 429 197) that the proton can travel along lipid membranes embedded into pure aqueous solutions, and (iv) predicts the dependence of the steady-state proton flux and the kinetics of the non-stationary diffusion upon the buffer concentration in buffered solutions. The surface diffusion coefficient for small unilaminar vesicles is calculated from experimental data (Sandén et al 2010 Proc. Natl Acad. Sci. USA 107 4129) to be 1 × 10(-5) cm(2) s(-1). The dependence of the shape of the kinetic curves representing protonation/deprotonation of a lipid-bound pH-sensitive dye attached to a planar bilayer lipid membrane upon the buffer concentration (Serowy et al 2003 Biophys. J. 84 1031) and the effect of changing the membrane composition (Antonenko and Pohl 2008 Eur. Biophys. J. 37 865) are explained. PMID:21613715

  12. Sulphonated imidized graphene oxide (SIGO) based polymer electrolyte membrane for improved water retention, stability and proton conductivity

    NASA Astrophysics Data System (ADS)

    Pandey, Ravi P.; Shahi, Vinod K.

    2015-12-01

    Sulphonated imidized graphene oxide (SIGO) (graphene oxide (GO) tethered sulphonated polyimide) has been successfully synthesized by polycondensation reaction using dianhydride and sulphonated diamine. Polymer electrolyte membranes (PEMs) are prepared by using SIGO (different wt%) and sulphonated poly(imide) (SPI). Resultant SPI/SIGO composite PEMs exhibit improved stabilities (thermal, mechanical and oxidative) and good water-retention properties (high bound water content responsible for proton conduction at high temperature by internal self-humidification). Incorporation of covalent bonded SIGO into SPI matrix results hydrophobic-hydrophilic phase separation and facile architecture of proton conducting path. Well optimized sulphonated poly(imide)/sulphonated imidized graphene oxide (15 wt%) (SPI/SIGO-15) composite membrane shows 2.24 meq g-1 ion-exchange capacity (IEC); 11.38 × 10-2 S cm-1 proton conductivity; 5.12% bound water content; and 10.52 × 10-7 cm2 s-1 methanol permeability. Maximum power density for pristine SPI membrane (57.12 mW cm-2) improves to 78.53 mW cm-2 for SPI/SIGO-15 membrane, in single-cell direct methanol fuel cell (DMFC) test at 70 °C using 2 M methanol fuel. Under similar experimental conditions, Nafion 117 membrane exhibits 62.40 mW cm-2 maximum power density. Reported strategy for the preparation of PEMs, offers a useful protocol for grafting of functionalized inorganic materials with in organic polymer chain by imidization.

  13. RHIC Polarized proton operation

    SciTech Connect

    Huang, H.; Ahrens, L.; Alekseev, I.G.; Aschenauer, E.; Atoian, G.; Bai, M.; Bazilevsky, A.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Connolly, R.; Dion, A.; D'Ottavio, T.; Drees, K.A.; Fischer, W.; Gardner, C.; Glenn, J.W.; Gu, X.; Harvey, M.; Hayes, T.; Hoff, L.; Hulsart, R.L.; Laster, J.; Liu, C.; Luo, Y.; MacKay, W.W.; Makdisi, Y.; Marr, G.J.; Marusic, A.; Meot, F.; Mernick, K.; Michnoff, R,; Minty, M.; Montag, C.; Morris, J.; Nemesure, S.; Poblaguev, A.; Ptitsyn, V.; Ranjibar, V.; Robert-Demolaize, G.; Roser, T.; J.; Severino, F.; Schmidke, B.; Schoefer, V.; Severino, F.; Smirnov, D.; Smith, K.; Steski, D.; Svirida, D.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J. Wang, G.; Wilinski, M.; Yip, K.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2011-03-28

    The Relativistic Heavy Ion Collider (RHIC) operation as the polarized proton collider presents unique challenges since both luminosity(L) and spin polarization(P) are important. With longitudinally polarized beams at the experiments, the figure of merit is LP{sup 4}. A lot of upgrades and modifications have been made since last polarized proton operation. A 9 MHz rf system is installed to improve longitudinal match at injection and to increase luminosity. The beam dump was upgraded to increase bunch intensity. A vertical survey of RHIC was performed before the run to get better magnet alignment. The orbit control is also improved this year. Additional efforts are put in to improve source polarization and AGS polarization transfer efficiency. To preserve polarization on the ramp, a new working point is chosen such that the vertical tune is near a third order resonance. The overview of the changes and the operation results are presented in this paper. Siberian snakes are essential tools to preserve polarization when accelerating polarized beams to higher energy. At the same time, the higher order resonances still can cause polarization loss. As seen in RHIC, the betatron tune has to be carefully set and maintained on the ramp and during the store to avoid polarization loss. In addition, the orbit control is also critical to preserve polarization. The higher polarization during this run comes from several improvements over last run. First we have a much better orbit on the ramp. The orbit feedback brings down the vertical rms orbit error to 0.1mm, much better than the 0.5mm last run. With correct BPM offset and vertical realignment, this rms orbit error is indeed small. Second, the jump quads in the AGS improved input polarization for RHIC. Third, the vertical tune was pushed further away from 7/10 snake resonance. The tune feedback maintained the tune at the desired value through the ramp. To calibrate the analyzing power of RHIC polarimeters at any energy above

  14. 26 CFR 1.4-3 - Husband and wife filing separate returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Husband and wife filing separate returns. 1.4-3... TAXES Normal Taxes and Surtaxes § 1.4-3 Husband and wife filing separate returns. (a) In general. If the separate adjusted gross income of a husband is less than $5,000 and the separate adjusted gross income...

  15. Laboratory Investigations Of Mechanisms For 1,4-Dioxane Destruction By Ozone In Water (Presentation)

    EPA Science Inventory

    Advances in analytical detection methods have made it possible to quantify 1,4-dioxane contamination in groundwater, even a well-characterized sites where it had not been previously detected. Although 1,4-dioxane is difficult to treat because of its chemical and physical propert...

  16. Bioactive 1 4-Dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1-4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by spectroscopic methods, and the absolute configuration of the major compound 1 by X-ray crystallographic a...

  17. 26 CFR 1.4-4 - Short taxable year caused by death.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Short taxable year caused by death. 1.4-4 Section... Normal Taxes and Surtaxes § 1.4-4 Short taxable year caused by death. An individual making a return for a... results from the death of the taxpayer. Tax on Corporations...

  18. IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR 1,4 - DIOXANE

    EPA Science Inventory

    1,4 -Dioxane is a cyclic ether that is primarily utilized for industrial applications. These applications include 1,4 -dioxane as a solvent, reaction medium, wetting, degreasing, and dispersing agent, and for stabilization of chlorinated solvents (e.g. 1,1,1 -trichloroethane). ...

  19. 26 CFR 1.4-4 - Short taxable year caused by death.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Short taxable year caused by death. 1.4-4... TAXES Normal Taxes and Surtaxes § 1.4-4 Short taxable year caused by death. An individual making a... taxable year results from the death of the taxpayer. Tax on Corporations...

  20. 26 CFR 1.4-4 - Short taxable year caused by death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Short taxable year caused by death. 1.4-4 Section... Normal Taxes and Surtaxes § 1.4-4 Short taxable year caused by death. An individual making a return for a... results from the death of the taxpayer. Tax on Corporations...

  1. 26 CFR 1.4-4 - Short taxable year caused by death.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Short taxable year caused by death. 1.4-4... TAXES Normal Taxes and Surtaxes § 1.4-4 Short taxable year caused by death. An individual making a... taxable year results from the death of the taxpayer. Tax on Corporations...

  2. 26 CFR 1.4-4 - Short taxable year caused by death.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Short taxable year caused by death. 1.4-4 Section... Normal Taxes and Surtaxes § 1.4-4 Short taxable year caused by death. An individual making a return for a... results from the death of the taxpayer. Tax on Corporations...

  3. IN-SITU OXIDATION OF 1,4-DIOXANE (LABORATORY RESULTS)

    EPA Science Inventory

    Interest in the solvent stabilizer, 1,4-dioxane, is increasing because analytical detection limits have decreased indicating its presence at chlorinated volatile organic compound contaminated sites. The most common method for removing 1,4-dioxane from contaminated water is advanc...

  4. Laboratory Investigation Of Mechanisms For 1,4-Dioxane Destruction By Ozone In Water

    EPA Science Inventory

    Advances in analytical detection methods have made it possible to quantify 1,4-dioxane contamination in groundwater, even at well-characterized sites where it had not been previously detected. Although 1,4-dioxane is difficult to treat because of its chemical and physical proper...

  5. 37 CFR 1.4 - Nature of correspondence and signature requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Nature of correspondence and signature requirements. 1.4 Section 1.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES General Provisions General Information and Correspondence §...

  6. 43 CFR 3135.1-4 - Effect of transfer of a tract.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Effect of transfer of a tract. 3135.1-4... MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL AND GAS LEASING: NATIONAL PETROLEUM RESERVE, ALASKA Transfers, Extensions, Consolidations, and Suspensions § 3135.1-4 Effect of transfer of...

  7. 37 CFR 1.4 - Nature of correspondence and signature requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Nature of correspondence and signature requirements. 1.4 Section 1.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES General Provisions General Information and Correspondence §...

  8. 20 CFR 1.4 - Where are other rules concerning OWCP functions found?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... functions found? 1.4 Section 1.4 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF... functions found? (a) The rules of the OWCP governing its functions under the Longshore and Harbor Workers' Compensation Act and its extensions are set forth in subchapter A of chapter VI of this title. (b) The rules...

  9. 21 CFR 177.1315 - Ethylene-1, 4-cyclohexylene dimethylene terephthalate copolymers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... glycol and 1 to 34 mole percent of 1,4-cyclo-hexanedimethanol (70 percent trans isomer, 30 percent cls isomer) Inherent viscosity of a 0.50 percent solution of the copolymer in phenol-tetrachloroethane (60:40... ethylene glycol and 1 to 15 mole percent of 1,4-cyclohexane-di-methanol (70 percent trans isomer,...

  10. 21 CFR 177.1315 - Ethylene-1, 4-cyclohexylene dimethylene terephthalate copolymers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... glycol and 1 to 34 mole percent of 1,4-cyclo-hexanedimethanol (70 percent trans isomer, 30 percent cls isomer) Inherent viscosity of a 0.50 percent solution of the copolymer in phenol-tetrachloroethane (60:40... ethylene glycol and 1 to 15 mole percent of 1,4-cyclohexane-di-methanol (70 percent trans isomer,...

  11. 21 CFR 177.1315 - Ethylene-1, 4-cyclohexylene dimethylene terephthalate copolymers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... glycol and 1 to 34 mole percent of 1,4-cyclo-hexanedimethanol (70 percent trans isomer, 30 percent cls isomer) Inherent viscosity of a 0.50 percent solution of the copolymer in phenol-tetrachloroethane (60:40... ethylene glycol and 1 to 15 mole percent of 1,4-cyclohexane-di-methanol (70 percent trans isomer,...

  12. 21 CFR 177.1315 - Ethylene-1, 4-cyclohexylene dimethylene terephthalate copolymers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... glycol and 1 to 34 mole percent of 1,4-cyclo-hexanedimethanol (70 percent trans isomer, 30 percent cls isomer) Inherent viscosity of a 0.50 percent solution of the copolymer in phenol-tetrachloroethane (60:40... ethylene glycol and 1 to 15 mole percent of 1,4-cyclohexane-di-methanol (70 percent trans isomer,...

  13. Multiple ionization of atomic targets by proton impact

    SciTech Connect

    Toburen, L.H.; DuBois, R.D.; Manson, S.T.

    1982-10-01

    We have combined experimental measurements of multiply charged ion production, doubly differential electron emission cross sections and Auger electron spectra produced in fast proton noble-gas collisions with theoretical inner and outer shell ionization cross sections in an effort to provide a consistent description of the ionization process. A detailed analysis is provided for 1-4 MeV proton ionization of krypton. Our measured relative yields of Kr/sup +2/ and Kr/sup +3/ ions are in approximate agreement with photoionization results of Krause and Carlson. If we assume nearly half of the 3d vacancies created in Kr are filled through multiple (3 dNNN) Auger transitions, the M-subshell ionization cross sections that we derive from our Auger electron spectra are in good agreement with theoretical calculations. The absolute yields of Kr/sup +2/ and Kr/sup +3/ are, however, a factor of 2 smaller than the calculated values.

  14. Eta Meson Production in Proton-Proton and Nuclear Collisions

    NASA Technical Reports Server (NTRS)

    Norbury, John W.; Dick, Frank

    2008-01-01

    Total cross sections for eta meson production in proton - proton collisions are calculated. The eta meson is mainly produced via decay of the excited nucleon resonance at 1535 MeV. A scalar quantum field theory is used to calculate cross sections, which also include resonance decay. Comparison between theory and experiment is problematic near threshold when resonance decay is not included. When the decay is included, the comparison between theory and experiment is much better.

  15. Development and Production of a 201 MHz, 5.0 MW Peak Power Klystron

    SciTech Connect

    Aymar, Galen; Eisen, Edward; Stockwell, Brad; Begum, rasheda; Lenci, Steve; Eisner, Rick; Cesca, Eugene

    2016-01-01

    Communications & Power Industries LLC has designed and manufactured the VKP-8201A, a high peak power, high gain, VHF band klystron. The klystron operates at 201.25 MHz, with 5.0 MW peak output power, 34 kW average output power, and a gain of 36 dB. The klystron is designed to operate between 1.0 MW and 4.5 MW in the linear range of the transfer curve. The klystron utilizes a unique magnetic field which enables the use of a proven electron gun design with a larger electron beam requirement. Experimental and predicted performance data are compared.

  16. Design of interaction cavity for 170 GHz, 1 MW ITER gyrotron

    SciTech Connect

    Kumar, Anil; Kumar, Nitin; Khatun, Hasina; Singh, Udaybir; Sinha, A.K. E-mail: aksinha@ceeri.ernet.in; Vyas, V.

    2011-07-01

    In this paper the design of interaction cavity for 170 GHz, 1 MW gyrotron is presented. An in-house developed code GCOMS has been used for operating mode selection and mode competition. For 170 GHz, 1 MW gyrotron interaction cavity TE28, 7 mode excite as a operating mode at the fundamental harmonic number. The electromagnetic simulator-MAGIC, a Particle-in-Cell (PIC) code has been used for the cold cavity analysis and the beam-wave interaction. More than 1MW output power has been achieved at guiding cavity magnetic field 6.77 T. (author)

  17. Dielectric response and anhydrous proton conductivity in a chiral framework containing a non-polar molecular rotor.

    PubMed

    Yu, Shan-Shan; Liu, Shao-Xian; Duan, Hai-Bao

    2015-12-28

    Herein, we report a chiral 3D framework with the formula [Co(HPO3)2][H2DABCO] (DABCO = 1,4-diazabicyclo[2.2.2]octane). This compound exhibits two distinct dielectric anomalies, one attributed to the transfer of protons between non-polar DABCO and the inorganic framework, and the other to the in-plane oscillatory fluctuation of the DABCO molecule. It also exhibits proton conductivity under high-temperature anhydrous conditions. PMID:26584424

  18. Degradation of 1,4-Dioxane and Cyclic Ethers by an Isolated Fungus

    PubMed Central

    Nakamiya, Kunichika; Hashimoto, Syunji; Ito, Hiroyasu; Edmonds, John S.; Morita, Masatoshi

    2005-01-01

    By using 1,4-dioxane as the sole source of carbon, a 1,4-dioxane-degrading microorganism was isolated from soil. The fungus, termed strain A, was able to utilize 1,4-dioxane and many kinds of cyclic ethers as the sole source of carbon and was identified as Cordyceps sinensis from its 18S rRNA gene sequence. Ethylene glycol was identified as a degradation product of 1,4-dioxane by the use of deuterated 1,4-dioxane-d8 and gas chromatography-mass spectrometry analysis. A degradation pathway involving ethylene glycol, glycolic acid, and oxalic acid was proposed, followed by incorporation of the glycolic acid and/or oxalic acid via glyoxylic acid into the tricarboxylic acid cycle. PMID:15746326

  19. Mn1.4Co1.4Cu0.2O4 spinel protective coating on ferritic stainless steels for solid oxide fuel cell interconnect applications

    NASA Astrophysics Data System (ADS)

    Chen, Guoyi; Xin, Xianshuang; Luo, Ting; Liu, Leimin; Zhou, Yuchun; Yuan, Chun; Lin, Chucheng; Zhan, Zhongliang; Wang, Shaorong

    2015-03-01

    In an attempt to reduce the oxidation and Cr evaporation rates of solid oxide fuel cells (SOFCs), Mn1.4Co1.4Cu0.2O4 spinel coating is developed on the Crofer22 APU ferritic stainless steel substrate by a powder reduction technique. Doping of Cu into Mn-Co spinels improves electrical conductivity as well as thermal expansion match with the Crofer22 APU interconnect. Good adhesion between the coating and the alloy substrate is achieved by the reactive sintering process using the reduced powders. Long-term isothermal oxidation experiment and area specific resistance (ASR) measurement are investigated. The ASR is less than 4 mΩ cm2 even though the coated alloy undergoes oxidation at 800 °C for 530 h and four thermal cycles from 800 °C to room temperature. The Mn1.4Co1.4Cu0.2O4 spinel coatings demonstrate excellent anti-oxidation performance and long-term stability. It exhibits a promising prospect for the practical application of SOFC alloy interconnect.

  20. Coseismic Coulomb stress changes caused by the Mw6.9 Yutian earthquake in 2014 and its correlation to the 2008 Mw7.2 Yutian earthquake

    NASA Astrophysics Data System (ADS)

    Li, Yujiang; Chen, Lianwang; Liu, Shaofeng; Yang, Shuxin; Yang, Xingyue; Zhang, Guangwei

    2015-06-01

    A three-dimensional viscoelastic finite element model of the Qinghai-Tibet Plateau and its adjacent regions was used to explore the relationship between the Mw7.2 Yutian earthquake in 2008 and the 2014 Mw6.9 Yutian earthquake. We further analyzed the Coulomb failure stress change caused by the Yutian Mw6.9 earthquake on faults surrounding the Bayan Har block and discussed the relationship between the Coulomb stress change and aftershock distribution. The preliminary results showed that: (1) The Coulomb failure stress change caused by the Mw7.2 Yutian earthquake in 2008, which was projected on the slip direction of the 2014 Yutian Mw6.9 earthquake, exceeded the earthquake triggering threshold of 0.01 MPa, implying an apparent triggering effect. Specifically, the coseismic Coulomb failure stress changes were 0.0167 MPa and 0.0170 MPa when assuming apparent friction coefficients of 0.4 and 0.6, respectively. The Coulomb failure stress changes, including viscoelastic relaxation effects, were 0.0187 MPa and 0.0194 MPa respectively. Combined with the tectonic stressing rate, the Mw6.9 Yutian earthquake in 2014 was advanced 21.4-24.9 years by the 2008 Mw7.2 Yutian earthquake; (2) The stress changes derived from the viscoelastic relaxation effect were much less than that from the coseismic effect, which was possibly interpreted as the shorter elapsed time between the two earthquakes relative to the characteristic time; (3) The Coulomb failure stresses increased on the mid-northern segment of the Altyn Tagh fault, the middle segment of the Mani-Yushu fault and the western segment of the eastern Kunlun fault, which demonstrated increasing seismic potential. In particular, the Coulomb failure stress on the middle segment of the Altyn Tagh fault increased by 2.8 × 103 Pa, the most significant increase. In contrast, the Coulomb failure stress decreased on the western segment of the Mani-Yushu and Minjiang faults, with the western segment of the Mani-Yushu fault dropping by 3

  1. Synthesis, spectral characterization, crystal structure and molecular docking study of 2,7-diaryl-1,4-diazepan-5-ones

    NASA Astrophysics Data System (ADS)

    Sethuvasan, S.; Sugumar, P.; Maheshwaran, V.; Ponnuswamy, M. N.; Ponnuswamy, S.

    2016-07-01

    In this study, a series of variously substituted r-2,c-7-diaryl-1,4-diazepan-5-ones 9-16 have been synthesized using Schmidt rearrangement and are characterized by IR, mass and 1D & 2D NMR spectral data. The proton NMR coupling constant and estimated dihedral angles reveal that the compounds 9-16 prefer a chair conformation with equatorial orientation of alkyl and aryl groups. Single crystal X-ray structure has been solved for compounds 9 and 11 which also indicates the preference for distorted chair conformation with equatorial orientation of substituents. The compounds 9-16 have been docked with the structure of Methicillin-resistant Staphylococcus aureus (MRSA) and the results demonstrate that compound 10 is having better docking score and glide energy than others and it is comparable to co-crystal ligand. Furthermore, all the compounds have been evaluated for their antibacterial and antioxidant activities. All the compounds show moderate antibacterial activity and only 11 exhibits better activity against S. aures and Escherichia coli. The compounds 11, 13 and 14 exhibit half of the antioxidant power when compared to the BHT and the remaining compounds show moderate activity.

  2. Thermodynamic Investigation and Mixed Ligand Complex Formation of 1,4-Bis-(3-aminopropyl)-piperazine and Biorelevant Ligands

    PubMed Central

    El-Sherif, Ahmed A.; Shehata, Mohamed R.; Shoukry, Mohamed M.; Barakat, Mohammad H.

    2012-01-01

    Thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) and its metal complexation with some divalent metal ions were determined in aqueous solution at constant ionic strength (0.1 M NaNO3) using a potentiometric technique. The order of –ΔG0 and –ΔH0 was found to obey Co2+ < Ni2+ < Cu2+ > Zn2+, in accordance with the Irving-Williams order. The formation equilibria of zinc (II) complexes and the ternary complexes Zn(BAPP)L, where L = amino acid, amides, or DNA constituents), have been investigated. Ternary complexes are formed by a simultaneous mechanism. The concentration distribution of the complexes in solution was evaluated as a function of pH. Stoichiometry and stability constants for the complexes formed are reported and discussed. The stability of ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameter Δlog K. PMID:23226992

  3. Synthesis, spectral characterization, crystal structure and molecular docking study of 2,7-diaryl-1,4-diazepan-5-ones

    NASA Astrophysics Data System (ADS)

    Sethuvasan, S.; Sugumar, P.; Maheshwaran, V.; Ponnuswamy, M. N.; Ponnuswamy, S.

    2016-07-01

    In this study, a series of variously substituted r-2,c-7-diaryl-1,4-diazepan-5-ones 9-16 have been synthesized using Schmidt rearrangement and are characterized by IR, mass and 1D & 2D NMR spectral data. The proton NMR coupling constant and estimated dihedral angles reveal that the compounds 9-16 prefer a chair conformation with equatorial orientation of alkyl and aryl groups. Single crystal X-ray structure has been solved for compounds 9 and 11 which also indicates the preference for distorted chair conformation with equatorial orientation of substituents. The compounds 9-16 have been docked with the structure of Methicillin-resistant Staphylococcus aureus (MRSA) and the results demonstrate that compound 10 is having better docking score and glide energy than others and it is comparable to co-crystal ligand. Furthermore, all the compounds have been evaluated for their antibacterial and antioxidant activities. All the compounds show moderate antibacterial activity and only 11 exhibits better activity against S. aures and Escherichia coli. The compounds 11, 13 and 14 exhibit half of the antioxidant power when compared to the BHT and the remaining compounds show moderate activity.

  4. Review of variations in Mw < 7 earthquake motions on position and tec (Mw = 6.5 aegean sea earthquake sample)

    NASA Astrophysics Data System (ADS)

    Yildirim, O.; Inyurt, S.; Mekik, C.

    2015-10-01

    Turkey is a country located in Middle Latitude zone and in which tectonic activity is intensive. Lastly, an earthquake of magnitude 6.5Mw occurred at Aegean Sea offshore on date 24 May 2014 at 12:25 UTC and it lasted approximately 40 s. The said earthquake was felt also in Greece, Romania and Bulgaria in addition to Turkey. In recent years seismic origin ionospheric anomaly detection studies have been done with TEC (Total Electron Contents) generated from GNSS (Global Navigation Satellite System) signals and the findings obtained have been revealed. In this study, TEC and positional variations have been examined seperately regarding the earthquake which occurred in the Aegean Sea. Then The correlation of the said ionospheric variation with the positional variation has been investigated. For this purpose, total fifteen stations have been used among which the data of four numbers of CORS-TR stations in the seismic zone (AYVL, CANA, IPSA, YENC) and IGS and EUREF stations are used. The ionospheric and positional variations of AYVL, CANA, IPSA and YENC stations have been examined by Bernese 5.0v software. When the (PPP-TEC) values produced as result of the analysis are examined, it has been understood that in the four stations located in Turkey, three days before the earthquake at 08:00 and 10:00 UTC, the TEC values were approximately 4 TECU above the upper limit TEC value. Still in the same stations, one day before the earthquake at 06:00, 08:00 and 10:00 UTC, it is being shown that the TEC values were approximately 5 TECU below the lower limit TEC value. On the other hand, the GIM-TEC values published by the CODE center have been examined. Still in all stations, it has been observed that three days before the earthquake the TEC values in the time portions of 08:00 and 10:00 UTC were approximately 2 TECU above, one day before the earthquake at 06:00, 08:00 and 10:00 UTC, the TEC values were approximately 4 TECU below the lower limit TEC value. Again, by using the same

  5. Review of variations in Mw < 7 earthquake motions on position and TEC (Mw = 6.5 Aegean Sea earthquake sample)

    NASA Astrophysics Data System (ADS)

    Yildirim, Omer; Inyurt, Samed; Mekik, Cetin

    2016-02-01

    Turkey is a country located in the middle latitude zone, where tectonic activity is intensive. Recently, an earthquake of magnitude 6.5 Mw occurred offshore in the Aegean Sea on 24 May 2014 at 09:25 UTC, which lasted about 40 s. The earthquake was also felt in Greece, Romania, and Bulgaria in addition to Turkey. In recent years, ionospheric anomaly detection studies have been carried out because of seismicity with total electron content (TEC) computed from the global navigation satellite system's (GNSS) signal delays and several interesting findings have been published. In this study, both TEC and positional variations have been examined separately following a moderate size earthquake in the Aegean Sea. The correlation of the aforementioned ionospheric variation with the positional variation has also been investigated. For this purpose, a total of 15 stations was used, including four continuously operating reference stations in Turkey (CORS-TR) and stations in the seismic zone (AYVL, CANA, IPSA, and YENC), as well as international GNSS service (IGS) and European reference frame permanent network (EPN) stations. The ionospheric and positional variations of the AYVL, CANA, IPSA, and YENC stations were examined using Bernese v5.0 software. When the precise point positioning TEC (PPP-TEC) values were examined, it was observed that the TEC values were approximately 4 TECU (total electron content unit) above the upper-limit TEC value at four stations located in Turkey, 3 days before the earthquake at 08:00 and 10:00 UTC. At the same stations, on the day before the earthquake at 06:00, 08:00, and 10:00 UTC, the TEC values were approximately 5 TECU below the lower-limit TEC value. The global ionosphere model TEC (GIM-TEC) values published by the Centre for Orbit Determination in Europe (CODE) were also examined. Three days before the earthquake, at all stations, it was observed that the TEC values in the time period between 08:00 and 10:00 UTC were approximately 2 TECU

  6. Specific receptor for inositol-1,4,5-trisphosphate in permeabilized rabbit neutrophils

    SciTech Connect

    Bradford, P.G.; Spat, A.; Rubin, R.P.

    1986-03-05

    Neutrophil chemotaxis and degranulation are resultant, in part, from the mobilization of intracellular calcium by inositol-1,4,5-trisphosphate ((1,4,5)IP/sub 3/), one of the products of chemoattractant-stimulated phospholipase C activity. High specific activity (ca. 40 Ci/mmol) (/sup 32/P)(1,4,5)IP/sub 3/ was prepared from (..gamma..-/sup 32/P)ATP-labeled human erythrocyte ghosts and was used in binding assays with saponin-permeabilized rabbit peritoneal neutrophils. At 4/sup 0/C and in the presence of inhibitors of the IP/sub 3/ 5-phosphomonoesterase, (/sup 32/P)(1,4,5)IP/sub 3/ rapidly associated with a specific binding component which saturated within 60s. Nonspecific binding, taken as the residual binding in the presence of 10 ..mu..M (1,4,5)IP/sub 3/, was 15% of the total. No specific binding was detected using intact cells. The specific binding to permeable cells was reversible (t/sup 1/2/ approx. 60s) and could be inhibited in a dose-dependent manner by (1,4,5)IP/sub 3/ (EC/sub 50/ = 30 nM) and by other calcium mobilizing inositol phosphates ((2,4,5)IP/sub 3/) but not by inactive analogs ((1,4)IP/sub 2/, (4,5)IP/sub 2/, (1)IP). The dose-responses of (1,4,5)IP/sub 3/ and (2,4,5)IP/sub 3/ in inhibiting (/sup 32/P)(1,4,5)IP/sub 3/ specific binding correlated well with their abilities to release Ca/sup 2 +/ from nonmitochondrial vesicular stores in the same preparation of cells, suggesting that the authors have identified the physiological receptor for (1,4,5)IP/sub 3/.

  7. Cosmic Ray Albedo Proton Yield Correlated with Lunar Elemental Abundances

    NASA Astrophysics Data System (ADS)

    Wilson, J. K.; Spence, H. E.; Case, A. W.; Blake, J. B.; Golightly, M. J.; Kasper, J. C.; Looper, M. D.; Mazur, J. E.; Schwadron, N. A.; Townsend, L. W.; Zeitlin, C. J.

    2012-12-01

    High energy cosmic rays constantly bombard the lunar regolith, producing secondary "albedo" or "splash" particles like protons and neutrons, some of which escape back to space. Two lunar missions, Lunar Prospector and the Lunar Reconnaissance Orbiter (LRO), have shown that the energy distribution of albedo neutrons is modulated by the elemental composition of the lunar regolith[1-4], with reduced neutron fluxes near the lunar poles being the result of collisions with hydrogen nuclei in ice deposits[5] in permanently shadowed craters. Here we investigate an analogous phenomenon with high energy (~100 MeV) lunar albedo protons. LRO has been observing the surface and environment of the Moon since June of 2009. The CRaTER instrument (Cosmic Ray Telescope for the Effects of Radiation) on LRO is designed to characterize the lunar radiation environment and its effects on simulated human tissue. CRaTER's multiple solid-state detectors can discriminate the different elements in the galactic cosmic ray (GCR) population above ~10 MeV/nucleon, and can also distinguish between primary GCR protons arriving from deep space and albedo particles propagating up from the lunar surface. We use albedo protons with energies greater than 60 MeV to construct a cosmic ray albedo proton map of the Moon. The yield of albedo protons is proportional to the rate of lunar proton detections divided by the rate of incoming GCR detections. The map accounts for time variation in the albedo particles driven by time variations in the primary GCR population, thus revealing any true spatial variation of the albedo proton yield. Our current map is a significant improvement over the proof-of-concept map of Wilson et al.[6]. In addition to including twelve more months of CRaTER data here, we use more numerous minimum ionizing GCR protons for normalization, and we make use of all six of CRaTER's detectors to reduce contamination from spurious non-proton events in the data stream. We find find that the flux

  8. High intensity proton synchrotrons

    NASA Astrophysics Data System (ADS)

    Craddock, M. K.

    1986-10-01

    Strong initiatives are being pursued in a number of countries for the construction of ``kaon factory'' synchrotrons capable of producing 100 times more intense proton beams than those available now from machines such as the Brookhaven AGS and CERN PS. Such machines would yield equivalent increases in the fluxes of secondary particles (kaons, pions, muons, antiprotons, hyperons and neutrinos of all varieties)—or cleaner beams for a smaller increase in flux—opening new avenues to various fundamental questions in both particle and nuclear physics. Major areas of investigation would be rare decay modes, CP violation, meson and hadron spectroscopy, antinucleon interactions, neutrino scattering and oscillations, and hypernuclear properties. Experience with the pion factories has already shown how high beam intensities make it possible to explore the ``precision frontier'' with results complementary to those achievable at the ``energy frontier''. This paper will describe proposals for upgrading and AGS and for building kaon factories in Canada, Europe, Japan and the United States, emphasizing the novel aspects of accelerator design required to achieve the desired performance (typically 100 μA at 30 GeV).

  9. Proton-Coupled Electron Transfer

    SciTech Connect

    Weinberg, Dave; Gagliardi, Christopher J.; Hull, Jonathan F; Murphy, Christine Fecenko; Kent, Caleb A.; Westlake, Brittany C.; Paul, Amit; Ess, Daniel H; McCafferty, Dewey Granville; Meyer, Thomas J

    2012-07-11

    Proton-Coupled Electron Transfer (PCET) describes reactions in which there is a change in both electron and proton content between reactants and products. It originates from the influence of changes in electron content on acid-base properties and provides a molecular-level basis for energy transduction between proton transfer and electron transfer. Coupled electron-proton transfer or EPT is defined as an elementary step in which electrons and protons transfer from different orbitals on the donor to different orbitals on the acceptor. There is (usually) a clear distinction between EPT and H-atom transfer (HAT) or hydride transfer, in which the transferring electrons and proton come from the same bond. Hybrid mechanisms exist in which the elementary steps are different for the reaction partners. EPT pathways such as PhO•/PhOH exchange have much in common with HAT pathways in that electronic coupling is significant, comparable to the reorganization energy with H{sub DA} ~ λ. Multiple-Site Electron-Proton Transfer (MS-EPT) is an elementary step in which an electron-proton donor transfers electrons and protons to different acceptors, or an electron-proton acceptor accepts electrons and protons from different donors. It exploits the long-range nature of electron transfer while providing for the short-range nature of proton transfer. A variety of EPT pathways exist, creating a taxonomy based on what is transferred, e.g., 1e-/2H+ MS-EPT. PCET achieves “redox potential leveling” between sequential couples and the buildup of multiple redox equivalents, which is of importance in multielectron catalysis. There are many examples of PCET and pH-dependent redox behavior in metal complexes, in organic and biological molecules, in excited states, and on surfaces. Changes in pH can be used to induce electron transfer through films and over long distances in molecules. Changes in pH, induced by local electron transfer, create pH gradients and a driving

  10. Anhydrous phosphoric Acid functionalized sintered mesoporous silica nanocomposite proton exchange membranes for fuel cells.

    PubMed

    Zeng, Jie; He, Beibei; Lamb, Krystina; De Marco, Roland; Shen, Pei Kang; Jiang, San Ping

    2013-11-13

    A novel inorganic proton exchange membrane based on phosphoric acid (PA)-functionalized sintered mesoporous silica, PA-meso-silica, has been developed and investigated. After sintering at 650 °C, the meso-silica powder forms a dense membrane with a robust and ordered mesoporous structure, which is critical for retention of PA and water within the porous material. The PA-meso-silica membrane achieved a high proton conductivity of 5 × 10(-3) to 5 × 10(-2) S cm(-1) in a temperature range of 80-220 °C, which is between 1 and 2 orders of magnitudes higher than a typical membrane Nafion 117 or polybenzimidazole (PBI)/PA in the absence of external humidification. Furthermore, the PA-meso-silica membranes exhibited good chemical stability along with high performance at elevated temperatures, producing a peak power density of 632 mW cm(-2) using a H2 fuel at 190 °C in the absence of external humidification. The high membrane proton conductivity and excellent fuel cell performance demonstrate the utility of PA-meso-silica as a new class of inorganic proton exchange membranes for use in the high-temperature proton exchange membrane fuel cells (PEMFCs). PMID:24125494

  11. Fate of 1,4-dioxane in the aquatic environment: from sewage to drinking water.

    PubMed

    Stepien, Daria K; Diehl, Peter; Helm, Johanna; Thoms, Alina; Püttmann, Wilhelm

    2014-01-01

    Potential health effects of 1,4-dioxane and the limited data on its occurrence in the water cycle command for more research. In the current study, mobility and persistence of 1,4-dioxane in the sewage-, surface-, and drinking water was investigated. The occurrence of 1,4-dioxane was determined in wastewater samples from four domestic sewage treatment plants (STP). The influent and effluent samples were collected during weekly campaigns. The average influent concentrations in all four plants ranged from 262 ± 32 ng L(-1) to 834 ± 480 ng L(-1), whereas the average effluent concentrations were between 267 ± 35 ng L(-1) and 62,260 ± 36,000 ng L(-1). No removal of 1,4-dioxane during water treatment was observed. Owing to its strong internal chemical bonding, 1,4-dioxane is considered non-biodegradable under conventional bio-treatment technologies. The source of increased 1,4-dioxane concentrations in the effluents was identified to originate from impurities in the methanol used in the postanoxic denitrification process in one of the STPs. In view of poor biodegradation in STPs, surface water samples were collected to establish an extent of 1,4-dioxane pollution. Spatial and temporal distribution of 1,4-dioxane in the Rivers Main, Rhine, and Oder was examined. Concentrations reaching 2200 ng L(-1) in the Oder River, and 860 ng L(-1) in both Main and Rhine River were detected. The average monthly load of 1,4-dioxane in the Rhine River was calculated to equal to 172 kg d(-1). In all rivers, concentration of 1,4-dioxane increased with distance from the spring and was found to negatively correlate with the discharge of the river. Additionally, bank filtration and drinking water samples from two drinking water facilities were analyzed for the presence of 1,4-dioxane. The raw water contained 650 ng L(-1)-670 ng L(-1) of 1,4-dioxane, whereas the concentration in the drinking water fell only to 600 ng L(-1) and 490 ng L(-1), respectively. Neither of the purification

  12. Parametric Model for Astrophysical Proton-Proton Interactions and Applications

    SciTech Connect

    Karlsson, Niklas

    2007-01-01

    Observations of gamma-rays have been made from celestial sources such as active galaxies, gamma-ray bursts and supernova remnants as well as the Galactic ridge. The study of gamma rays can provide information about production mechanisms and cosmic-ray acceleration. In the high-energy regime, one of the dominant mechanisms for gamma-ray production is the decay of neutral pions produced in interactions of ultra-relativistic cosmic-ray nuclei and interstellar matter. Presented here is a parametric model for calculations of inclusive cross sections and transverse momentum distributions for secondary particles--gamma rays, e±, ve, $\\bar{v}$e, vμ and $\\bar{μ}$e--produced in proton-proton interactions. This parametric model is derived on the proton-proton interaction model proposed by Kamae et al.; it includes the diffraction dissociation process, Feynman-scaling violation and the logarithmically rising inelastic proton-proton cross section. To improve fidelity to experimental data for lower energies, two baryon resonance excitation processes were added; one representing the Δ(1232) and the other multiple resonances with masses around 1600 MeV/c2. The model predicts the power-law spectral index for all secondary particle to be about 0.05 lower in absolute value than that of the incident proton and their inclusive cross sections to be larger than those predicted by previous models based on the Feynman-scaling hypothesis. The applications of the presented model in astrophysics are plentiful. It has been implemented into the Galprop code to calculate the contribution due to pion decays in the Galactic plane. The model has also been used to estimate the cosmic-ray flux in the Large Magellanic Cloud based on HI, CO and gamma-ray observations. The transverse momentum distributions enable calculations when the proton distribution is anisotropic. It is shown that the gamma-ray spectrum and flux due to a

  13. Proton beam monitor chamber calibration.

    PubMed

    Gomà, C; Lorentini, S; Meer, D; Safai, S

    2014-09-01

    The first goal of this paper is to clarify the reference conditions for the reference dosimetry of clinical proton beams. A clear distinction is made between proton beam delivery systems which should be calibrated with a spread-out Bragg peak field and those that should be calibrated with a (pseudo-)monoenergetic proton beam. For the latter, this paper also compares two independent dosimetry techniques to calibrate the beam monitor chambers: absolute dosimetry (of the number of protons exiting the nozzle) with a Faraday cup and reference dosimetry (i.e. determination of the absorbed dose to water under IAEA TRS-398 reference conditions) with an ionization chamber. To compare the two techniques, Monte Carlo simulations were performed to convert dose-to-water to proton fluence. A good agreement was found between the Faraday cup technique and the reference dosimetry with a plane-parallel ionization chamber. The differences-of the order of 3%-were found to be within the uncertainty of the comparison. For cylindrical ionization chambers, however, the agreement was only possible when positioning the effective point of measurement of the chamber at the reference measurement depth-i.e. not complying with IAEA TRS-398 recommendations. In conclusion, for cylindrical ionization chambers, IAEA TRS-398 reference conditions for monoenergetic proton beams led to a systematic error in the determination of the absorbed dose to water, especially relevant for low-energy proton beams. To overcome this problem, the effective point of measurement of cylindrical ionization chambers should be taken into account when positioning the reference point of the chamber. Within the current IAEA TRS-398 recommendations, it seems advisable to use plane-parallel ionization chambers-rather than cylindrical chambers-for the reference dosimetry of pseudo-monoenergetic proton beams. PMID:25109620

  14. High intensity protons in RHIC

    SciTech Connect

    Montag, C.; Ahrens, L.; Blaskiewicz, M.; Brennan, J. M.; Drees, K. A.; Fischer, W.; Huang, H.; Minty, M.; Robert-Demolaize, G.; Thieberger, P.; Yip, K.

    2012-01-05

    During the 2012 summer shutdown a pair of electron lenses will be installed in RHIC, allowing the beam-beam parameter to be increased by roughly 50 percent. To realize the corresponding luminosity increase bunch intensities have to be increased by 50 percent, to 2.5 {center_dot} 10{sup 11} protons per bunch. We list the various RHIC subsystems that are most affected by this increase, and propose beam studies to ensure their readiness. The proton luminosity in RHIC is presently limited by the beam-beam effect. To overcome this limitation, electron lenses will be installed in IR10. With the help of these devices, the headon beam-beam kick experienced during proton-proton collisions will be partially compensated, allowing for a larger beam-beam tuneshift at these collision points, and therefore increasing the luminosity. This will be accomplished by increasing the proton bunch intensity from the presently achieved 1.65 {center_dot} 10{sup 11} protons per bunch in 109 bunches per beam to 2.5 {center_dot} 10{sup 11}, thus roughly doubling the luminosity. In a further upgrade we aim for bunch intensities up to 3 {center_dot} 10{sup 11} protons per bunch. With RHIC originally being designed for a bunch intensity of 1 {center_dot} 10{sup 11} protons per bunch in 56 bunches, this six-fold increase in the total beam intensity by far exceeds the design parameters of the machine, and therefore potentially of its subsystems. In this note, we present a list of major subsystems that are of potential concern regarding this intensity upgrade, show their demonstrated performance at present intensities, and propose measures and beam experiments to study their readiness for the projected future intensities.

  15. Understanding the proton's spin structure

    SciTech Connect

    Fred Myhrer; Thomas, Anthony W.

    2010-02-01

    We discuss the tremendous progress that has been towards an understanding of how the spin of the proton is distributed on its quark and gluon constituents. This is a problem that began in earnest twenty years ago with the discovery of the proton "spin crisis" by the European Muon Collaboration. The discoveries prompted by that original work have given us unprecedented insight into the amount of spin carried by polarized gluons and the orbital angular momentum of the quarks.

  16. Voltage-gated Proton Channels

    PubMed Central

    DeCoursey, Thomas E.

    2014-01-01

    Voltage-gated proton channels, HV1, have vaulted from the realm of the esoteric into the forefront of a central question facing ion channel biophysicists, namely the mechanism by which voltage-dependent gating occurs. This transformation is the result of several factors. Identification of the gene in 2006 revealed that proton channels are homologues of the voltage-sensing domain of most other voltage-gated ion channels. Unique, or at least eccentric, properties of proton channels include dimeric architecture with dual conduction pathways, perfect proton selectivity, a single-channel conductance ~103 smaller than most ion channels, voltage-dependent gating that is strongly modulated by the pH gradient, ΔpH, and potent inhibition by Zn2+ (in many species) but an absence of other potent inhibitors. The recent identification of HV1 in three unicellular marine plankton species has dramatically expanded the phylogenetic family tree. Interest in proton channels in their own right has increased as important physiological roles have been identified in many cells. Proton channels trigger the bioluminescent flash of dinoflagellates, facilitate calcification by coccolithophores, regulate pH-dependent processes in eggs and sperm during fertilization, secrete acid to control the pH of airway fluids, facilitate histamine secretion by basophils, and play a signaling role in facilitating B-cell receptor mediated responses in B lymphocytes. The most elaborate and best-established functions occur in phagocytes, where proton channels optimize the activity of NADPH oxidase, an important producer of reactive oxygen species. Proton efflux mediated by HV1 balances the charge translocated across the membrane by electrons through NADPH oxidase, minimizes changes in cytoplasmic and phagosomal pH, limits osmotic swelling of the phagosome, and provides substrate H+ for the production of H2O2 and HOCl, reactive oxygen species crucial to killing pathogens. PMID:23798303

  17. Proton assisted recoupling and protein structure determination

    PubMed Central

    De Paëpe, Gaël; Lewandowski, Józef R.; Loquet, Antoine; Böckmann, Anja; Griffin, Robert G.

    2008-01-01

    We introduce a homonuclear version of third spin assisted recoupling, a second-order mechanism that can be used for polarization transfer between 13C or 15N spins in magic angle spinning (MAS) NMR experiments, particularly at high spinning frequencies employed in contemporary high field MAS experiments. The resulting sequence, which we refer to as proton assisted recoupling (PAR), relies on a cross-term between 1H–13C (or 1H–15N) couplings to mediate zero quantum 13C–13C (or 15N–15N recoupling). In particular, using average Hamiltonian theory we derive an effective Hamiltonian for PAR and show that the transfer is mediated by trilinear terms of the form C1±C2∓HZ for 13C–13C recoupling experiments (or N1±N2∓HZ for 15N–15N). We use analytical and numerical simulations to explain the structure of the PAR optimization maps and to delineate the PAR matching conditions. We also detail the PAR polarization transfer dependence with respect to the local molecular geometry and explain the observed reduction in dipolar truncation. Finally, we demonstrate the utility of PAR in structural studies of proteins with 13C–13C spectra of uniformly 13C, 15N labeled microcrystalline Crh, a 85 amino acid model protein that forms a domain swapped dimer (MW=2×10.4 kDa). The spectra, which were acquired at high MAS frequencies (ωr2π>20 kHz) and magnetic fields (750–900 MHz 1H frequencies) using moderate rf fields, exhibit numerous cross peaks corresponding to long (up to 6–7 Å) 13C–13C distances which are particularly useful in protein structure determination. Using results from PAR spectra we calculate the structure of the Crh protein. PMID:19123534

  18. Proton assisted recoupling and protein structure determination

    NASA Astrophysics Data System (ADS)

    de Paëpe, Gaël; Lewandowski, Józef R.; Loquet, Antoine; Böckmann, Anja; Griffin, Robert G.

    2008-12-01

    We introduce a homonuclear version of third spin assisted recoupling, a second-order mechanism that can be used for polarization transfer between 13C or 15N spins in magic angle spinning (MAS) NMR experiments, particularly at high spinning frequencies employed in contemporary high field MAS experiments. The resulting sequence, which we refer to as proton assisted recoupling (PAR), relies on a cross-term between 1H-13C (or 1H-15N) couplings to mediate zero quantum 13C-13C (or 15N-15N recoupling). In particular, using average Hamiltonian theory we derive an effective Hamiltonian for PAR and show that the transfer is mediated by trilinear terms of the form C1+/-C2-/+HZ for 13C-13C recoupling experiments (or N1+/-N2-/+HZ for 15N-15N). We use analytical and numerical simulations to explain the structure of the PAR optimization maps and to delineate the PAR matching conditions. We also detail the PAR polarization transfer dependence with respect to the local molecular geometry and explain the observed reduction in dipolar truncation. Finally, we demonstrate the utility of PAR in structural studies of proteins with 13C-13C spectra of uniformly 13C, 15N labeled microcrystalline Crh, a 85 amino acid model protein that forms a domain swapped dimer (MW=2×10.4 kDa). The spectra, which were acquired at high MAS frequencies (ωr2π>20 kHz) and magnetic fields (750-900 MHz 1H frequencies) using moderate rf fields, exhibit numerous cross peaks corresponding to long (up to 6-7 A˚) 13C-13C distances which are particularly useful in protein structure determination. Using results from PAR spectra we calculate the structure of the Crh protein.

  19. A beam intensity monitor for the Loma Linda cancer therapy proton accelerator

    SciTech Connect

    Coutrakon, G.; Miller, D. ); Kross, B.J.; Anderson, D.F. ); DeLuca, P. Jr.; Siebers, J. )

    1991-07-01

    A beam intensity monitor was tested in a 230-MeV proton beam at the Loma Linda Proton Therapy Accelerator during its commissioning at Fermi National Accelerator Laboratory. The intensity monitor was designed to regulate the beam intensity extracted from the proton synchrotron. The proton beam is tunable between 70 and 250 MeV with an adjustable intensity between 10{sup 10} and 10{sup 11} protons per spill. A beam spill is typically 1 s long with a 2-s repetition period. The intensity monitor must be radiation hard, expose minimum mass to the beam, and measure intensity to 1% in 1-ms time intervals. To this end, a 5-cm-thick xenon gas scintillator optically coupled to a photomultiplier tube (PMT) was tested to measure its response to the proton beam. The gas cell was operated at 1.2 atm of pressure and has 12.7-{mu}m-thick titanium entrance and exit foils. The total mass exposed to the beam is 0.14 g/cm{sup 2} and is dominated by the titanium windows. This mass corresponds to a range attenuation equal to 1.4 mm of water. The energy lost to the xenon gas is about 70 keV per proton. Each passing proton will produce approximately 2000 photons. With a detection efficiency on the order of 0.05% for this UV light, one would anticipate over 10{sup 10} photoelectrons per second. In a 1-ms time bin there will be approximately 10{sup 7} photoelectrons. This yields a resolution limited by systematics. For unregulated 0.4-s proton spills, we observe a response bandwidth in excess of 10{sup 4} Hz. While signal-to-noise and linearity were not easily measured, we estimate as few as 10{sup 3} protons can be observed suggesting a dynamic range in excess of 10{sup 5} is available.

  20. A beam intensity monitor for the Loma Linda cancer therapy proton accelerator.

    PubMed

    Coutrakon, G; Miller, D; Kross, B J; Anderson, D F; DeLuca, P; Siebers, J

    1991-01-01

    A beam intensity monitor was tested in a 230-MeV proton beam at the Loma Linda Proton Therapy Accelerator during its commissioning at Fermi National Accelerator Laboratory. The intensity monitor was designed to regulate the beam intensity extracted from the proton synchrotron. The proton beam is tunable between 70 and 250 MeV with an adjustable intensity between 10(10) and 10(11) protons per spill. A beam spill is typically 1 s long with a 2-s repetition period. The intensity monitor must be radiation hard, expose minimum mass to the beam, and measure intensity to 1% in 1-ms time intervals. To this end, a 5-cm-thick xenon gas scintillator optically coupled to a photomultiplier tube (PMT) was tested to measure its response to the proton beam. The gas cell was operated at 1.2 atm of pressure and has 12.7-microns-thick titanium entrance and exit foils. The total mass exposed to the beam is 0.14 g/cm2 and is dominated by the titanium windows. This mass corresponds to a range attenuation equal to 1.4 mm of water. The energy lost to the xenon gas is about 70 keV per proton. Each passing proton will produce approximately 2000 photons. With a detection efficiency on the order of 0.05% for this UV light, one would anticipate over 10(10) photoelectrons per second. In a 1-ms time bin there will be approximately 10(7) photoelectrons. This yields a resolution limited by systematics. For unregulated 0.4-s proton spills, we observe a response bandwidth in excess of 10(4) Hz. While signal-to-noise and linearity were not easily measured, we estimate as few as 10(3) protons can be observed suggesting a dynamic range in excess of 10(5) is available. PMID:1656180

  1. Generation of proton aurora by magnetosonic waves

    PubMed Central

    Xiao, Fuliang; Zong, Qiugang; Wang, Yongfu; He, Zhaoguo; Su, Zhenpeng; Yang, Chang; Zhou, Qinghua

    2014-01-01

    Earth's proton aurora occurs over a broad MLT region and is produced by the precipitation of low-energy (2–10 keV) plasmasheet protons. Proton precipitation can alter chemical compositions of the atmosphere, linking solar activity with global climate variability. Previous studies proposed that electromagnetic ion cyclotron waves can resonate with protons, producing proton scattering precipitation. A long-outstanding question still remains whether there is another mechanism responsible for the proton aurora. Here, by performing satellite data analysis and diffusion equation calculations, we show that fast magnetosonic waves can produce trapped proton scattering that yields proton aurora. This provides a new insight into the mechanism of proton aurora. Furthermore, a ray-tracing study demonstrates that magnetosonic wave propagates over a broad MLT region, consistent with the global distribution of proton aurora. PMID:24898626

  2. Distribution of 1,4-dioxane in relation to possible sources in the water environment.

    PubMed

    Abe, A

    1999-02-16

    The distribution of 1,4-dioxane was investigated in surface and groundwater in relation to possible sources. Water samples from river, coastal sea, and groundwater were collected and examined in Kanagawa Prefecture, Japan, from 1995 to 1998. Almost all samples were contaminated by 1,4-dioxane. On annual changes, the concentrations did not vary significantly in river water. However, some samples were still heavily polluted in groundwater. The highest correlation was between the concentration of 1,4-dioxane and 1,1,1-trichloroethane in the polluted groundwater samples. Soil and groundwater that was polluted by 1,1,1-trichloroethane in the past is still a possible source of 1,4-dioxane. In regard to a survey of other sources, effluents from the combined collection treatment from apartment houses, river basin sewage systems, and chemical plants were examined. The load unit of 1,4-dioxane from the treated effluent of domestic wastewater was assumed to be approximately 0.25 mg/person/day. This was derived from commonly used household chemicals, which contained 1,4-dioxane as a by-product. In river basin sewage systems, the concentrations in effluents varied significantly. High concentration inflows were probably not degraded and released. Although 50-60% of removal was recognized in acclimatized activated sludge from a chemical plant, 1,4-dioxane was easily desorbed with water from sludge. PMID:10209880

  3. Regulation of Human Kv1.4 Channel Activity by the Antidepressant Metergoline.

    PubMed

    Yeom, Hye Duck; Lee, Jun-Ho

    2016-01-01

    Metergoline is an ergot-derived psychoactive drug that is a ligand for various serotonin and dopamine receptors. Little is known about the effect of metergoline on different types of receptors and ion channels. Potassium channels are the most diverse group of ion channels. Kv1.4, a shaker family K channel alpha subunit, is one of a family of voltage gated K channels that mediates transient and rapid inactivating A-type currents and N-type inactivation. We demonstrated previously that metergoline inhibited the activity of neuronal voltage-dependent Na(+) channels in Xenopus laevis oocytes (Acta Pharmacol. Sin., 35, 2014, Lee et al.). In this study, we sought to elucidate the regulatory effects underlying metergoline-induced human Kv1.4 channel inhibition. We used the two electrode voltage-clamp (TEVC) technique to investigate the effect of metergoline on human Kv1.4 channel currents in Xenopus laevis oocytes expressing human Kv1.4 alpha subunits. Interestingly, metergoline treatment also induced inhibition of peak currents in human Kv1.4 channels in a concentration-dependent manner. The IC50 of peak currents of hKv1.4 currents was 3.6±0.6 µM. These results indicate that metergoline might regulate the human Kv1.4 channel activity that is expressed in X. laevis oocytes. Further, this regulation of potassium currents by metergoline might be one of the pharmacological actions of metergoline-mediated psychoactivity. PMID:27251511

  4. Metabolic Degradation of 1,4-dichloronaphthalene by Pseudomonas sp. HY

    PubMed Central

    Yu, Jian; Wu, Xiaoli; Song, Youqun; Ren, Wenhui; Tang, Hao L.

    2015-01-01

    There is increasing concern regarding the adverse health effects of polychlorinated naphthalenes (PCNs). The metabolic degradation of 1,4-dichloronaphthalene (1,4-DCN) as a model PCN, was studied using a strain of Pseudomonas sp. HY. The metabolites were analyzed by gas chromatography-mass spectrometry (GC-MS). A series of metabolites including dihydroxy-dichloro-naphthalene, epoxy-dichlorinated naphthalene, dichlorinated naphthol, and dichlorinated salicylic acid were identified. The time-concentration plots of the degradation curves of 1,4-DCN was also obtained from the experiments, which set the initial concentration of 1,4-DCN to 10 mg/L and 20 mg/L, respectively. The results showed that 98% removal could be achieved within 48 h at an initial 1,4-DCN concentration of 10 mg/L. Nevertheless, it took 144 h to reach the same degradation efficiency at an initial concentration of 20 mg/L. The degradation of 1,4-DCN may not remove the chloride ions during the processes and the metabolites may not benefit the bacterial growth. The research suggests a metabolic pathway of 1,4-DCN, which is critical for the treatment of this compound through biological processes. PMID:26308037

  5. High performance cobalt-free Cu1.4Mn1.6O4 spinel oxide as an intermediate temperature solid oxide fuel cell cathode

    NASA Astrophysics Data System (ADS)

    Zhen, Shuying; Sun, Wang; Li, Peiqian; Tang, Guangze; Rooney, David; Sun, Kening; Ma, Xinxin

    2016-05-01

    In this work Cu1.4Mn1.6O4 (CMO) spinel oxide is prepared and evaluated as a novel cobalt-free cathode for intermediate temperature solid oxide fuel cells (IT-SOFCs). Single phase CMO powder with cubic structure is identified using XRD. XPS results confirm that mixed Cu+/Cu2+ and Mn3+/Mn4+ couples exist in the CMO sample, and a maximum conductivity of 78 S cm-1 is achieved at 800 °C. Meanwhile, CMO oxide shows good thermal and chemical compatibility with a 10 mol% Sc2O3 stabilized ZrO2 (ScSZ) electrolyte material. Impedance spectroscopy measurements reveals that CMO exhibits a low polarization resistance of 0.143 Ω cm2 at 800 °C. Furthermore, a Ni-ScSZ/ScSZ/CMO single cell demonstrates a maximum power density of 1076 mW cm-2 at 800 °C under H2 (3% H2O) as the fuel and ambient air as the oxidant. These results indicate that Cu1.4Mn1.6O4 is a superior and promising cathode material for IT-SOFCs.

  6. Development of Proton Computed Tomography for Applications in Proton Therapy

    NASA Astrophysics Data System (ADS)

    Bashkirov, Vladimir; Schulte, Reinhard; Coutrakon, George; Erdelyi, Bela; Wong, Kent; Sadrozinski, Hartmut; Penfold, Scott; Rosenfeld, Anatoly; McAllister, Scott; Schubert, Keith

    2009-03-01

    Determination of the Bragg peak position in proton therapy requires accurate knowledge of the electron density and ratio of effective atomic number and mass (Z/A) of the body tissues traversed. While the Z/A ratio is fairly constant for human tissues, the density of tissues varies significantly. One possibility to obtain accurate electron density information of tissues is to use protons of sufficient energy to penetrate the patient and measure their energy loss. From these transmission measurements, it is possible to reconstruct a three-dimensional map of electron densities using algebraic techniques. The interest in proton computed tomography (pCT) has considerably increased in recent years due to the more common use of proton accelerators for cancer treatment world-wide and a modern design concept based on current high-energy physics technology has been suggested. This contribution gives a status update on the pCT project carried out by the pCT Collaboration, a group of institutions sharing interest and expertise in the development of pCT. We will present updated imaging data obtained with a small pCT prototype developed in collaboration with the Santa Cruz Institute of Particle Physics and installed on the proton research beam line at Loma Linda University Medical Center. We will discuss hardware decisions regarding the next-generation pCT scanner, which will permit scanning of head-sized objects. Progress has also been made in the formulation of the most likely path of protons through an object and parallelizable iterative reconstruction algorithms that can be implemented on general-purpose commodity graphics processing units. Finally, we will present simulation studies for utilizing pCT technology for on-line proton dose verification and tumor imaging with positron emission tomography (PET).

  7. Development of Proton Computed Tomography for Applications in Proton Therapy

    SciTech Connect

    Bashkirov, Vladimir; Schulte, Reinhard; Coutrakon, George; Erdelyi, Bela; Wong, Kent; Sadrozinski, Hartmut; Penfold, Scott; Rosenfeld, Anatoly; McAllister, Scott; Schubert, Keith

    2009-03-10

    Determination of the Bragg peak position in proton therapy requires accurate knowledge of the electron density and ratio of effective atomic number and mass (Z/A) of the body tissues traversed. While the Z/A ratio is fairly constant for human tissues, the density of tissues varies significantly. One possibility to obtain accurate electron density information of tissues is to use protons of sufficient energy to penetrate the patient and measure their energy loss. From these transmission measurements, it is possible to reconstruct a three-dimensional map of electron densities using algebraic techniques. The interest in proton computed tomography (pCT) has considerably increased in recent years due to the more common use of proton accelerators for cancer treatment world-wide and a modern design concept based on current high-energy physics technology has been suggested. This contribution gives a status update on the pCT project carried out by the pCT Collaboration, a group of institutions sharing interest and expertise in the development of pCT. We will present updated imaging data obtained with a small pCT prototype developed in collaboration with the Santa Cruz Institute of Particle Physics and installed on the proton research beam line at Loma Linda University Medical Center. We will discuss hardware decisions regarding the next-generation pCT scanner, which will permit scanning of head-sized objects. Progress has also been made in the formulation of the most likely path of protons through an object and parallelizable iterative reconstruction algorithms that can be implemented on general-purpose commodity graphics processing units. Finally, we will present simulation studies for utilizing pCT technology for on-line proton dose verification and tumor imaging with positron emission tomography (PET)

  8. Lymphocyte responses to DR1/4 restricted peptides in rheumatoid arthritis.

    PubMed Central

    Skinner, M A; Watson, L; Geursen, A; Tan, P L

    1994-01-01

    OBJECTIVE--To determine whether analog and unrelated DR1/4 binding peptides alter DR1/4 restricted responses of peripheral blood lymphocytes (PBL) from patients with rheumatoid arthritis (RA). METHODS--PBL from 25 patients with RA and 12 healthy controls were cultured with DR1/4 restricted peptides of the influenza haemagglutinin, amino acids 307-319 (HA) and matrix proteins, amino acids 17-29 (IM). Responses were determined by 3H-thymidine uptake proliferation assays and limiting dilution analysis. Competitor peptides were analogs HA-R312 and HA-K313 differing from HA by one amino acid at the 312 or 313 position respectively or unrelated peptides which bind to DR1/4. RESULTS--The responses of eight patients with RA to the two stimulatory influenza peptides did not differ significantly from controls and this was confirmed by the frequency estimate of T cells in PBL which responded to HA (mean frequency: 1 in 9.0 x 10(4), n = 5, in DR1/4+ RA patients, 1 in 7.6 x 10(4), n = 5, in DR1/4+ healthy controls). DR1/4 binding analogs of the HA peptide inhibited HA specific peptide responses of PBL from patients with RA and controls. Inhibition was also detected with unrelated peptides which bind to DR1/4 but to which the individual did not respond. CONCLUSION--Similar responses to two DR1/4 restricted peptides were observed in patients with RA and controls. Both antigen analog- and unrelated peptide-major histocompatibility complexes (MHC) can result in the inhibition of antigen specific responses in multi-clonal human lymphocyte populations. However, an analog peptide may be stimulatory in some individuals. These results provide some initial data for the development of a rational approach to MHC-specific immunomodulation in rheumatoid arthritis. Images PMID:8154934

  9. Identification of Biomarker Genes To Predict Biodegradation of 1,4-Dioxane

    PubMed Central

    Gedalanga, Phillip B.; Pornwongthong, Peerapong; Mora, Rebecca; Chiang, Sheau-Yun Dora; Baldwin, Brett; Ogles, Dora

    2014-01-01

    Bacterial multicomponent monooxygenase gene targets in Pseudonocardia dioxanivorans CB1190 were evaluated for their use as biomarkers to identify the potential for 1,4-dioxane biodegradation in pure cultures and environmental samples. Our studies using laboratory pure cultures and industrial activated sludge samples suggest that the presence of genes associated with dioxane monooxygenase, propane monooxygenase, alcohol dehydrogenase, and aldehyde dehydrogenase are promising indicators of 1,4-dioxane biotransformation; however, gene abundance was insufficient to predict actual biodegradation. A time course gene expression analysis of dioxane and propane monooxygenases in Pseudonocardia dioxanivorans CB1190 and mixed communities in wastewater samples revealed important associations with the rates of 1,4-dioxane removal. In addition, transcripts of alcohol dehydrogenase and aldehyde dehydrogenase genes were upregulated during biodegradation, although only the aldehyde dehydrogenase was significantly correlated with 1,4-dioxane concentrations. Expression of the propane monooxygenase demonstrated a time-dependent relationship with 1,4-dioxane biodegradation in P. dioxanivorans CB1190, with increased expression occurring after over 50% of the 1,4-dioxane had been removed. While the fraction of P. dioxanivorans CB1190-like bacteria among the total bacterial population significantly increased with decrease in 1,4-dioxane concentrations in wastewater treatment samples undergoing active biodegradation, the abundance and expression of monooxygenase-based biomarkers were better predictors of 1,4-dioxane degradation than taxonomic 16S rRNA genes. This study illustrates that specific bacterial monooxygenase and dehydrogenase gene targets together can serve as effective biomarkers for 1,4-dioxane biodegradation in the environment. PMID:24632253

  10. Biodegradation Kinetics of 1,4-Dioxane in Chlorinated Solvent Mixtures.

    PubMed

    Zhang, Shu; Gedalanga, Phillip B; Mahendra, Shaily

    2016-09-01

    This study investigated the impacts of individual chlorinated solvents and their mixtures on aerobic 1,4-dioxane biodegradation by Pseudonocardia dioxanivorans CB1190. The established association of these co-occurring compounds suggests important considerations for their respective biodegradation processes. Our kinetics and mechanistic studies demonstrated that individual solvents inhibited biodegradation of 1,4-dioxane in the following order: 1,1-dichloroethene (1,1-DCE) > cis-1,2-diochloroethene (cDCE) > trichloroethene (TCE) > 1,1,1-trichloroethane (TCA). The presence of 5 mg L(-1) 1,1-DCE completely inhibited 1,4-dioxane biodegradation. Subsequently, we determined that 1,1-DCE was the strongest inhibitor of 1,4-dioxane biodegradation by bacterial pure cultures exposed to chlorinated solvent mixtures as well as in environmental samples collected from a site contaminated with chlorinated solvents and 1,4-dioxane. Inhibition of 1,4-dioxane biodegradation rates by chlorinated solvents was attributed to delayed ATP production and down-regulation of both 1,4-dioxane monooxygenase (dxmB) and aldehyde dehydrogenase (aldH) genes. Moreover, increasing concentrations of 1,1-DCE and cis-1,2-DCE to 50 mg L(-1) respectively increased 5.0-fold and 3.5-fold the expression of the uspA gene encoding a universal stress protein. In situ natural attenuation or enhanced biodegradation of 1,4-dioxane is being considered for contaminated groundwater and industrial wastewater, so these results will have implications for selecting 1,4-dioxane bioremediation strategies at sites where chlorinated solvents are present as co-contaminants. PMID:27486928

  11. Performance of the H- Ion Source Supporting 1-MW Beam Operations at SNS

    NASA Astrophysics Data System (ADS)

    Han, B. X.; Hardek, T.; Kang, Y.; Murray, S. N.; Pennisi, T. R.; Piller, C.; Santana, M.; Welton, R. F.; Stockli, M. P.

    2011-09-01

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory reached 1-MW of beam power in September 2009, and now routinely operates near 1-MW for the production of neutrons. This paper reviews the performance, operational issues, implemented and planned mitigations of the SNS H- ion source to support such high power-level beams with high availability. Some results from R&D activities are also briefly described.

  12. Performance of the H{sup -} Ion Source Supporting 1-MW Beam Operations at SNS

    SciTech Connect

    Han, B. X.; Hardek, T.; Kang, Y.; Murray, S. N. Jr.; Pennisi, T. R.; Piller, C.; Santana, M.; Welton, R. F.; Stockli, M. P.

    2011-09-26

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory reached 1-MW of beam power in September 2009, and now routinely operates near 1-MW for the production of neutrons. This paper reviews the performance, operational issues, implemented and planned mitigations of the SNS H{sup -} ion source to support such high power-level beams with high availability. Some results from R and D activities are also briefly described.

  13. Performance of the H- Ion Source Supporting 1-MW Beam Operations at SNS

    SciTech Connect

    Han, Baoxi; Hardek, Thomas W; Kang, Yoon W; Murray Jr, S N; Pennisi, Terry R; Piller, Chip; Santana, Manuel; Welton, Robert F; Stockli, Martin P

    2011-01-01

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory reached 1-MW of beam power in September 2009, and now routinely operates near 1-MW for the production of neutrons. This paper reviews the performance, operational issues, implemented and planned mitigations of the SNS H- ion source to support such high power-level beams with high availability. Some results from R&D activities are also briefly described.

  14. Copper-promoted synthesis of 1,4-benzodiazepinones via alkene diamination

    PubMed Central

    Karyakarte, Shuklendu D.; Sequeira, Fatima C.; Zibreg, Garrick H.; Huang, Guoqing; Matthew, Josiah P.; Ferreira, Marina M. M.

    2015-01-01

    A new method for the synthesis of 2-aminomethyl functionalized 1,4-benzodiazepin-5-ones is presented. The benzodiazepine core is well-known to interact with biological receptors and many pharmaceutical drugs are derived from this structure. The alkene diamination strategy is employed for the first time for the synthesis of 1,4-benzodiazepinones. In this reaction, copper(2-ethylhexanoate)2 serves as promoter and a range of external amines can be coupled with 2-sulfonamido-N-allyl benzamides to generate the 1,4-benzodiazepinones in good yields. PMID:26034340

  15. [Cytogenetic effects of 1,4-dihydropyridine in various test systems].

    PubMed

    Kuzhir, T D; Goncharova, R I; Zolotareva, G N

    1984-01-01

    Cytogenetic effect of 1,4-dihydropyridine was studied in different test-systems. The preparation is shown to decrease the level of complete sex-chromosome losses in Drosophila and chromosome aberration frequency in Allium fistulosum seedlings. The preparation does not affect spontaneous mutability of bone marrow cells in mice, high doses of the preparation have no mutagenic potential. Thus, 1,4-dihydropyridine shows antimutagenic activity reducing the chromosome mutation level in sex and somatic cells of eucaryotic organisms. Absence of the effect on mice chromosomes may testify to the specificity of 1,4-dihydropyridine action. PMID:6506216

  16. Hydrogen consentration meter utilizing a diffusion tube composed of 2 1/4 C r

    DOEpatents

    Roy, Prodyot; Sandusky, David W.; Hartle, Robert T.

    1979-01-01

    A diffusion tube hydrogen meter for improving the sensitivity and response time for the measurement of hydrogen in liquid sodium. The improved hydrogen meter has a composite membrane composed of pure nickel sleeve fitted, for example, over a 2 1/4 Cr-1 Mo steel or niobium diffusion tube. Since the hydrogen permeation rate through 2 1/4 Cr-1 Mo steels is a factor of four higher than pure nickel, and the permeation rate of hydrogen through niobium is two orders of magnitude greater than the 2 1/4 Cr-1 Mo steel, this results in a decrease in response time and an increase in the sensitivity.

  17. Beta 1,4-oligoglucosides inhibit the binding of Aspergillus fumigatus conidia to human monocytes.

    PubMed

    Kan, V L; Bennett, J E

    1991-05-01

    The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley beta-glucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (beta 1,3) and cellobiose (beta 1,4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with beta 1,4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of beta 1,4-linked glucose residues led to greater inhibition of conidial binding by human monocytes. PMID:2019764

  18. Synthesis and antiinflammatory activity of 6-Acylsubstituted benzo-1,4-dioxanes and dihydrobenzopyrans

    SciTech Connect

    Daukshas, V.K.; Brukshtus, A.B.; Gaidyalis, P.G.; Pyatrauskas, O.Yu.; Udrenaite, E.B.

    1986-07-01

    6-Acylsubstituted benzo-1,4-dioxanes and dihydrobenzopyrans were synthesized by the Friedel-Crafts reaction by the acylation of benzo-1,4-dioxane or corresponding dihydrobenzopyran with an acid chloride in the presence of anhydrous AlCl/sub 3/; the ketone was obtained by the hydrogenation of the chalcone using Raney nickel. The antiinflammatory activity was studied on experimental models of carragheen and bentonite edema of the foot of white rats. Results indicate that derivatives of benzo-1,4-dioxane and dihydrobenzopyran of the type studied show promise as antiinflammatory agents.

  19. Processable, high temperature polymers from 1,4,5,8-tetrahydro-1,4;5,8-diepoxyanthracene and bis-dienes

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B.

    1988-01-01

    1,4,5,8-tetrahydro-1,4;5,8-diepoxyanthracene reacts with various anthracene end-capped polyimide oligomers to form Diels-Alder cycloaddition copolymers. The polymers are soluble in common organic solvents, and have molecular weights of approximately 21,000 to 32,000. These resins exhibit lower weight loss in air than in nitrogen. This is suggested to be due to dehydration (loss of water ranges from 2 to 5 percent) at temperatures of 390 to 400 C to give thermooxidatively stable pentiptycene units along the polymer backbone. Because of their high softening points and good thermooxidative stability, the polymers have potential as processable, matrix resins for high temperature composite applications.

  20. Addition polymers from 1,4,5,8-tetrahydro-1,4;5,8-diepoxyanthracene and Bis-dienes: Processable resins for high temperature application

    NASA Technical Reports Server (NTRS)

    Meador, Mary Ann B.

    1987-01-01

    1,4,5,8-Tetrahydro-1,4;5,8-diepoxyanthracene reacts with various anthracene endcapped polyimide oligomers to form Diels-Alder cycloaddition copolymers. The polymers are soluble in common organic solvents, and have molecular weights of approximately 21,000 to 32,000. Interestingly, these resins appear to be more stable in air then in nitrogen. This is shown to be due to a unique dehydration (loss of water ranges from 2 to 5 percent) at temperatures of 390 to 400 C to give thermo-oxidatively stable pentiptycene units along the polymer backbone. Because of their high softening points and good thermo-oxidative stability, the polymers have potential as processible, matrix resins for high temperature composite applications.

  1. Studies on molecular structure, vibrational spectra and molecular docking analysis of 3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-aminobenzoate

    NASA Astrophysics Data System (ADS)

    Suresh, D. M.; Amalanathan, M.; Hubert Joe, I.; Bena Jothy, V.; Diao, Yun-Peng

    2014-09-01

    The molecular structure, vibrational analysis and molecular docking analysis of the 3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-aminobenzoate (MDDNAB) molecule have been carried out using FT-IR and FT-Raman spectroscopic techniques and DFT method. The equilibrium geometry, harmonic vibrational wave numbers, various bonding features have been computed using density functional method. The calculated molecular geometry has been compared with experimental data. The detailed interpretation of the vibrational spectra has been carried out by using VEDA program. The hyper-conjugative interactions and charge delocalization have been analyzed using natural bond orbital (NBO) analysis. The simulated FT-IR and FT-Raman spectra satisfactorily coincide with the experimental spectra. The PES and charge analysis have been made. The molecular docking was done to identify the binding energy and the Hydrogen bonding with the cancer protein molecule.

  2. Resistance of medical gloves to permeation by methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and 1,4-butanediol dimethacrylate (1,4-BDMA).

    PubMed

    Lönnroth, Emma-Christin; Eystein Ruyter, I

    2003-01-01

    Gloves afford hand protection by minimizing skin contact. The effectiveness of medical gloves to protect against permeation of the monomers, methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and 1,4-butanediol dimethacrylate (1,4-BDMA), was assessed focusing on permeation rates and degradation of glove materials caused by monomer contact. Fifteen different brands of gloves were tested using a European Standard procedure. Surface images of glove materials before and after exposure to the monomer mixture were obtained using a scanning electron microscope. The standard is not applicable as the only method for estimating the safety of gloves, but it is useful as guideline together with the cumulative permeation of acrylic monomers. Monomer contact on the outside resulted in substantial swelling of most glove materials, and structure changes of the inside surface. PMID:14577946

  3. Sparse-view proton computed tomography using modulated proton beams

    SciTech Connect

    Lee, Jiseoc; Kim, Changhwan; Cho, Seungryong; Min, Byungjun; Kwak, Jungwon; Park, Seyjoon; Lee, Se Byeong; Park, Sungyong

    2015-02-15

    Purpose: Proton imaging that uses a modulated proton beam and an intensity detector allows a relatively fast image acquisition compared to the imaging approach based on a trajectory tracking detector. In addition, it requires a relatively simple implementation in a conventional proton therapy equipment. The model of geometric straight ray assumed in conventional computed tomography (CT) image reconstruction is however challenged by multiple-Coulomb scattering and energy straggling in the proton imaging. Radiation dose to the patient is another important issue that has to be taken care of for practical applications. In this work, the authors have investigated iterative image reconstructions after a deconvolution of the sparsely view-sampled data to address these issues in proton CT. Methods: Proton projection images were acquired using the modulated proton beams and the EBT2 film as an intensity detector. Four electron-density cylinders representing normal soft tissues and bone were used as imaged object and scanned at 40 views that are equally separated over 360°. Digitized film images were converted to water-equivalent thickness by use of an empirically derived conversion curve. For improving the image quality, a deconvolution-based image deblurring with an empirically acquired point spread function was employed. They have implemented iterative image reconstruction algorithms such as adaptive steepest descent-projection onto convex sets (ASD-POCS), superiorization method–projection onto convex sets (SM-POCS), superiorization method–expectation maximization (SM-EM), and expectation maximization-total variation minimization (EM-TV). Performance of the four image reconstruction algorithms was analyzed and compared quantitatively via contrast-to-noise ratio (CNR) and root-mean-square-error (RMSE). Results: Objects of higher electron density have been reconstructed more accurately than those of lower density objects. The bone, for example, has been reconstructed

  4. Nuclear proton dynamics and interactions with calcium signaling.

    PubMed

    Hulikova, Alzbeta; Swietach, Pawel

    2016-07-01

    Biochemical signals acting on the nucleus can regulate gene expression. Despite the inherent affinity of nucleic acids and nuclear proteins (e.g. transcription factors) for protons, little is known about the mechanisms that regulate nuclear pH (pHnuc), and how these could be exploited to control gene expression. Here, we show that pHnuc dynamics can be imaged using the DNA-binding dye Hoechst 33342. Nuclear pores allow the passage of medium-sized molecules (calcein), but protons must first bind to mobile buffers in order to gain access to the nucleoplasm. Fixed buffering residing in the nucleus of permeabilized cells was estimated to be very weak on the basis of the large amplitude of pHnuc transients evoked by photolytic H(+)-uncaging or exposure to weak acids/bases. Consequently, the majority of nuclear pH buffering is sourced from the cytoplasm in the form of mobile buffers. Effective proton diffusion was faster in nucleoplasm than in cytoplasm, in agreement with the higher mobile-to-fixed buffering ratio in the nucleus. Cardiac myocyte pHnuc changed in response to maneuvers that alter nuclear Ca(2+) signals. Blocking Ca(2+) release from inositol-1,4,5-trisphosphate receptors stably alkalinized the nucleus. This Ca(2+)-pH interaction may arise from competitive binding to common chemical moieties. Competitive binding to mobile buffers may couple the efflux of Ca(2+)via nuclear pores with a counterflux of protons. This would generate a stable pH gradient between cytoplasm and nucleus that is sensitive to the state of nuclear Ca(2+) signaling. The unusual behavior of protons in the nucleus provides new mechanisms for regulating cardiac nuclear biology. PMID:26183898

  5. P1 Trisaccharide (Galα1,4Galβ1,4GlcNAc) Synthesis by Enzyme Glycosylation Reactions Using Recombinant Escherichia coli

    PubMed Central

    Liu, Ziye; Lu, Yuquan; Zhang, Jianbo; Pardee, Keith; Wang, Peng George

    2003-01-01

    The frequency of Escherichia coli infection has lead to concerns over pathogenic bacteria in our food supply and a demand for therapeutics. Glycolipids on gut cells serve as receptors for the Shiga-like toxin produced by E. coli. Oligosaccharide moiety analogues of these glycolipids can compete with receptors for the toxin, thus acting as antibacterials. An enzymatic synthesis of the P1 trisaccharide (Galα1,4Galβ1,4GlcNAc), one of the oligosaccharide analogues, was assessed in this study. In the proposed synthetic pathway, UDP-glucose was generated from sucrose with an Anabaena sp. sucrose synthase and then converted with an E. coli UDP-glucose 4-epimerase to UDP-galactose. Two molecules of galactose were linked to N-acetylglucosamine subsequently with a Helicobacter pylori β-l,4-galactosyltransferase and a Neisseria meningitidis α-1,4-galactosyltransferase to produce one molecule of P1 trisaccharide. The four enzymes were coexpressed in a single genetically engineered E. coli strain that was then permeabilized and used to catalyze the enzymatic reaction. P1 trisaccharide was accumulated up to 50 mM (5.4 g in a 200-ml reaction volume), with a 67% yield based on the consumption of N-acetylglucosamine. This study provides an efficient approach for the preparative-scale synthesis of P1 trisaccharide with recombinant bacteria. PMID:12676690

  6. Side Elevation; 1/4 Plans of Floor Framing, Floor Planking, Roof ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Side Elevation; 1/4 Plans of Floor Framing, Floor Planking, Roof Framing and Roof; Longitudinal Section, Cross Section, End Elevation - Eames Covered Bridge, Spanning Henderson Creek, Oquawka, Henderson County, IL

  7. Multiple Views of X1.4 Solar Flare on July 12, 2012

    NASA Video Gallery

    This video shows the July 12, 2012 X1.4 class solar flare in a variety of wavelength; 131- Teal colored, 335 - blue colored, 171 - yellow colored and finally a combined wavelength view. All video w...

  8. Process for the production of 1:4 butanediol from maleic anhydride via ester hydrogenation

    SciTech Connect

    Towers, R.G.; Harris, N.; McKee, D.

    1986-01-01

    A process has been developed for the production of 1:4 butanediol (1:4 BDO from maleic anhydride (MA). The three process steps are:- a) Esterifiction of MA to produce a dialkyl maleate ester based on a modification of commercially proven esterification technology; b) Hydrogenation of the ester, at moderate temperatures and pressures, to 1:4 BD using novel low pressure ester hydrogenation technology. Gamma-Butyrolactone (gamma-BL) and tetrahydrofuran (THF) are produced as co-products. The 1:4 BD/Gamma-BL product ratio can be adjusted to respond to market requirements by recycle of the less desirable product, and THF productivity controlled over wide limits by variation of process parameters; c) Product separation by distillation.

  9. Implications of matrix diffusion on 1,4-dioxane persistence at contaminated groundwater sites.

    PubMed

    Adamson, David T; de Blanc, Phillip C; Farhat, Shahla K; Newell, Charles J

    2016-08-15

    Management of groundwater sites impacted by 1,4-dioxane can be challenging due to its migration potential and perceived recalcitrance. This study examined the extent to which 1,4-dioxane's persistence was subject to diffusion of mass into and out of lower-permeability zones relative to co-released chlorinated solvents. Two different release scenarios were evaluated within a two-layer aquifer system using an analytical modeling approach. The first scenario simulated a 1,4-dioxane and 1,1,1-TCA source zone where spent solvent was released. The period when 1,4-dioxane was actively loading the low-permeability layer within the source zone was estimated to be <3years due to its high effective solubility. While this was approximately an order-of-magnitude shorter than the loading period for 1,1,1-TCA, the mass of 1,4-dioxane stored within the low-permeability zone at the end of the simulation period (26kg) was larger than that predicted for 1,1,1-TCA (17kg). Even 80years after release, the aqueous 1,4-dioxane concentration was still several orders-of-magnitude higher than potentially-applicable criteria. Within the downgradient plume, diffusion contributed to higher concentrations and enhanced penetration of 1,4-dioxane into the low-permeability zones relative to 1,1,1-TCA. In the second scenario, elevated 1,4-dioxane concentrations were predicted at a site impacted by migration of a weak source from an upgradient site. Plume cutoff was beneficial because it could be implemented in time to prevent further loading of the low-permeability zone at the downgradient site. Overall, this study documented that 1,4-dioxane within transmissive portions of the source zone is quickly depleted due to characteristics that favor both diffusion-based storage and groundwater transport, leaving little mass to treat using conventional means. Furthermore, the results highlight the differences between 1,4-dioxane and chlorinated solvent source zones, suggesting that back diffusion of 1,4

  10. Thermal rearrangements in 1,2-poly/1,4-hexadiene/s

    NASA Technical Reports Server (NTRS)

    Golub, M. A.

    1978-01-01

    The work described was carried out to study the thermal rearrangements of two unsaturated diene polymers - 1,2-poly(cis-1,4-hexadiene) (CHD) and 1,2-poly(trans-1.4-hexadiene) (THD). It is shown that both CHD and THD have a predominatly 1,8 diene structure and seem to cyclize mainly by the (2 + 2) thermal cycloaddition of double bonds, and to a small extent also by sigmatropic rearrangement with hydrogen shift.

  11. Estimating health risk from exposure to 1,4-dioxane in Japan.

    PubMed

    Makino, Ryoji; Kawasaki, Hajime; Kishimoto, Atsuo; Gamo, Masashi; Nakanishi, Junko

    2006-01-01

    Exposure to 1,4-dioxane from the atmosphere around high-emission plants and from consumer products used in daily life that contain the substance may have adverse health effects; however, its emission into the atmosphere is not regulated. In this study, the health risk posed by 1,4-dioxane is assessed to investigate whether measures should be undertaken to reduce exposure to 1,4-dioxane. The notion of the margin of exposure (MOE), given by the ratio of no observed adverse effect level (NOAEL) to actual or projected exposure level, is used to assess risk. In exposure assessment, two types of exposure channel are considered: (a) the use of consumer products that contain 1,4-dioxane and (b) the inhalation of air around high-emission plants. To estimate exposure via channel (a), we measured the concentration of 1,4-dioxane in consumer products and estimated the interindividual variability of exposure by Monte Carlo simulation that reflects the measured data. To estimate exposure via channel (b), we employed a local-level atmospheric dispersion model to estimate the concentration of 1,4-dioxane immediately around high-emission plants. For hazard assessment, we derived the inhalatory and oral NOAELs for liver adenomas and carcinomas and the uncertainty factor. The results suggest that measures are not needed to reduce exposure to 1,4-dioxane from consumer products. As for inhalation exposure around high-emission plants, some residents may be exposed to health risks if certain conservative analytical conditions are assumed. Even in this case, we conclude that it is not necessary for Plant A to stop the use of 1,4-dioxane immediately and that medium- to long-term emission reduction measures should be sufficient. PMID:16685251

  12. Effective mass of the four-flux composite fermion at {nu}=1/4

    SciTech Connect

    Pan, W.; National High Magnetic Field Laboratory, Tallahassee, Florida 32310 ; Stormer, H. L.; Department of Physics and Department of Applied Physics, Columbia University, New York, New York 10027 ; Tsui, D. C.; Pfeiffer, L. N.; Baldwin, K. W.; West, K. W.

    2000-02-15

    We have measured the effective mass (m{sup *}) of the four flux composite fermion at Landau-level filling factor {nu}=1/4 ({sup 4}CF), using the activation energy gaps at the fractional quantum Hall effect states {nu}=2/7, 3/11, and 4/15 and the temperature dependence of the Shubnikov-de Haas (SdH) oscillations around {nu}=1/4. We find that the energy gaps show a linear dependence on the effective magnetic field B{sub eff} ({identical_to}B-B{sub {nu}}{sub =1/4}), and from this linear dependence we obtain m{sup *}=1.0m{sub e} and a disorder broadening {gamma}{approx}1 K for a sample of density n=0.87x10{sup 11} cm{sup -2}. The m{sup *} deduced from the temperature dependence of the SdH effect shows large differences for {nu}>1/4 and {nu}<1/4. For {nu}>1/4, m{sup *}{approx}1.0m{sub e}. It scales as {radical}(B{sub {nu}}) with the mass derived from the data around {nu}=1/2 and shows an increase in m{sup *} as {nu}{yields}1/4, resembling the findings around {nu}=1/2. For {nu}<1/4, m{sup *} increases rapidly with increasing B{sub eff} and can be described by m{sup *}/m{sub e}=-3.3+5.7B{sub eff}. This anomalous dependence on B{sub eff} is precursory to the formation of the insulating phase at still lower filling. (c) 2000 The American Physical Society.

  13. Production and identification of wheat - Agropyron cristatum (1.4P) alien translocation lines.

    PubMed

    Liu, Wei-Hua; Luan, Yang; Wang, Jing-Chang; Wang, Xiao-Guang; Su, Jun-Ji; Zhang, Jin-Peng; Yang, Xin-Ming; Gao, Ai-Nong; Li, Li-Hui

    2010-06-01

    The P genome of Agropyron Gaertn., a wild relative of wheat, contains an abundance of desirable genes that can be utilized as genetic resources to improve wheat. In this study, wheat - Aegilops cylindrica Host gametocidal chromosome 2C addition lines were crossed with wheat - Agropyron cristatum (L.) Gaertn. disomic addition line accession II-21 with alien recombinant chromosome (1.4)P. We successfully induced wheat - A. cristatum alien chromosomal translocations for the first time. The frequency of translocation in the progeny was 3.75%, which was detected by molecular markers and genomic in situ hybridization (GISH). The translocation chromosomes were identified by dual-color GISH /fluorescence in situ hybridization (FISH). The P genomic DNA was used as probe to detect the (1.4)P chromosome fragment, and pHvG39, pAs1, or pSc119.2 repeated sequences were used as probes to identify wheat translocated chromosomes. The results showed that six types of translocations were identified in the three wheat - A. cristatum alien translocation lines, including the whole arm or terminal portion of a (1.4)P chromosome. The (1.4)P chromosome fragments were translocated to wheat chromosomes 1B, 2B, 5B, and 3D. The breakpoints were located at the centromeres of 1B and 2B, the pericentric locations of 5BS, and the terminals of 5BL and 3DS. In addition, we obtained 12 addition-deletion lines that contained alien A. cristatum chromosome (1.4)P in wheat background. All of these wheat - A. cristatum alien translocation lines and addition-deletion lines would be valuable for identifying A. cristatum chromosome (1.4)P-related genes and providing genetic resources and new germplasm accessions for the genetic improvement of wheat. The specific molecular markers of A. cristatum (1.4)P chromosome have been developed and used to track the (1.4)P chromatin. PMID:20555436

  14. Bioactive 1,4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells.

    PubMed

    Borovic, Suzana; Tirzitis, Gunars; Tirzite, Dace; Cipak, Ana; Khoschsorur, Gholam A; Waeg, Georg; Tatzber, Franz; Scukanec-Spoljar, Mira; Zarkovic, Neven

    2006-05-10

    1,4-Dihydroisonicotinic acid derivatives (1,4-DHINA) are compounds closely related to derivatives of 1,4-dihydropyridine, a well-known calcium channel antagonists. 1,4-DHINA we used were derived from a well-known antioxidant Diludin. Although some compounds have neuromodulatory or antimutagenic properties, their activity mechanisms are not well known. This study was performed to obtain data on antioxidant and bioprotective activities of: 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid (Ia); sodium 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido)glutamate (Ib) and sodium 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido)ethane-sulphate (Ic). 1,4-DHINA's activities were studied in comparison to Trolox by: N,N-Diphenyl-N'-picrylhydrazyl (DPPH*), deoxyribose degradation, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical scavenging and antioxidative capacity assays; copper-induced lipid peroxidation of cultured rat liver cells (malondialdehyde determination by high performance liquid chromatography and 4-hydroxynonenal-protein conjugates by dot-blot); (3)H-thymidine incorporation and trypan blue assay for liver cells growth and viability. In all assays used Ia was the most potent antioxidant. Ia was also a potent antioxidant at non-toxic concentrations for liver cell cultures. It completely abolished, while Ic only slightly decreased copper-induced lipid peroxidation of liver cells. Thus, antioxidant capacities are important activity principle of Ia, which was even superior to Trolox in the cell cultures used, while activity principles of Ic and Ib remain yet to be determined. PMID:16600211

  15. Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison

    PubMed Central

    Loussouarn, Gildas; Sternberg, Damien; Nicole, Sophie; Marionneau, Céline; Le Bouffant, Francoise; Toumaniantz, Gilles; Barc, Julien; Malak, Olfat A.; Fressart, Véronique; Péréon, Yann; Baró, Isabelle; Charpentier, Flavien

    2016-01-01

    Mutations in Nav1.4 and Nav1.5 α-subunits have been associated with muscular and cardiac channelopathies, respectively. Despite intense research on the structure and function of these channels, a lot of information is still missing to delineate the various physiological and pathophysiological processes underlying their activity at the molecular level. Nav1.4 and Nav1.5 sequences are similar, suggesting structural and functional homologies between the two orthologous channels. This also suggests that any characteristics described for one channel subunit may shed light on the properties of the counterpart channel subunit. In this review article, after a brief clinical description of the muscular and cardiac channelopathies related to Nav1.4 and Nav1.5 mutations, respectively, we compare the knowledge accumulated in different aspects of the expression and function of Nav1.4 and Nav1.5 α-subunits: the regulation of the two encoding genes (SCN4A and SCN5A), the associated/regulatory proteins and at last, the functional effect of the same missense mutations detected in Nav1.4 and Nav1.5. First, it appears that more is known on Nav1.5 expression and accessory proteins. Because of the high homologies of Nav1.5 binding sites and equivalent Nav1.4 sites, Nav1.5-related results may guide future investigations on Nav1.4. Second, the analysis of the same missense mutations in Nav1.4 and Nav1.5 revealed intriguing similarities regarding their effects on membrane excitability and alteration in channel biophysics. We believe that such comparison may bring new cues to the physiopathology of cardiac and muscular diseases. PMID:26834636

  16. Imaging B. anthracis heme catabolism in mice using the IFP1.4 gene reporter

    NASA Astrophysics Data System (ADS)

    Zhu, Banghe; Robinson, Holly; Wilganowski, Nathaniel; Nobles, Christopher L.; Sevick-Muraca, Eva; Maresso, Anthony

    2012-03-01

    B. anthracis is a gram-positive, spore-forming bacterium which likes all pathogenic bacteria, survive by sequestering heme from its host. To image B. anthracis heme catabolism in vivo, we stably transfect new red excitable fluorescent protein, IFP1.4, that requires the heme catabolism product biliverdin (BV). IFP1.4 reporter has favorable excitation and emission characteristics, which has an absorption peak at 685 nm and an emission peak at 708 nm. Therefore, IFP1.4 reporter can be imaged deeply into the tissue with less contamination from tissue autofluorescence. However, the excitation light "leakage" through optical filters can limit detection and sensitivity of IFP1.4 reporter due to the small Stoke's shift of IFP1.4 fluorescence. To minimize the excitation light leakage, an intensified CCD (ICCD) based infrared fluorescence imaging device was optimized using two band pass filters separated by a focus lens to increase the optical density at the excitation wavelength. In this study, a mouse model (DBA/J2) was first injected with B. anthracis bacteria expressing IFP1.4, 150 μl s.c., on the ventral side of the left thigh. Then mouse was given 250 μl of a 1mM BV solution via I.V. injection. Imaging was conducted as a function of time after infection under light euthanasia, excised tissues were imaged and IFP1.4 fluorescence correlated with standard culture measurements of colony forming units (CFU). The work demonstrates the use of IFP1.4 as a reporter of bacterial utilization of host heme and may provide an important tool for understanding the pathogenesis of bacterial infection and developing new anti-bacterial therapeutics.

  17. Novel composite proton-exchange membrane based on proton-conductive glass powders and sulfonated poly (ether ether ketone)

    NASA Astrophysics Data System (ADS)

    Di, Zhigang; Xie, Qiang; Li, Haibin; Mao, Dali; Li, Ming; Zhou, Daowu; Li, Lu

    2015-01-01

    The SiO2-Nafion/sulfonated poly (ether ether ketone) (SPEEK) composite membranes are fabricated by using the simple mechanical ball-milling process to combine SiO2 glass powders with small portion of Nafion, in which SiO2 glass powders are prepared by modified sol-gel progress and Nafion is embedded in situ into a highly porous silica network. The morphology, thermal and mechanical properties, pore structure, proton conductivity and fuel cell performance of the SiO2-Nafion/SPEEK composite membranes are investigated. The poor miscibility of Nafion and sulfonated aromatic polymer is solved by fixing Nafion into SiO2 glass powders. The composite membranes perform well even if the proportion of inorganic component in membranes is as high as 40 wt.%. A maximum of proton conductivity, 0.018 S cm-1, is obtained from the membrane of 4(8Si-2N)/6SPEEK at 80 °C and 90% relative humidity, which is owing to its enhanced hygroscopicity and highly dispersed Nafion clusters. In addition, a single fuel cell equipped with the composite membrane shows a peak power density of 589.2 mW cm-2 at 70 °C.

  18. Microbially driven Fenton reaction for degradation of the widespread environmental contaminant 1,4-dioxane.

    PubMed

    Sekar, Ramanan; DiChristina, Thomas J

    2014-11-01

    The carcinogenic cyclic ether compound 1,4-dioxane is employed as a stabilizer of chlorinated industrial solvents and is a widespread environmental contaminant in surface water and groundwater. In the present study, a microbially driven Fenton reaction was designed to autocatalytically generate hydroxyl (HO•) radicals that degrade 1,4-dioxane. In comparison to conventional (purely abiotic) Fenton reactions, the microbially driven Fenton reaction operated at circumneutral pH and did not the require addition of exogenous H2O2 or UV irradiation to regenerate Fe(II) as Fenton reagents. The 1,4-dioxane degradation process was driven by pure cultures of the Fe(III)-reducing facultative anaerobe Shewanella oneidensis manipulated under controlled laboratory conditions. S. oneidensis batch cultures were provided with lactate, Fe(III), and 1,4-dioxane and were exposed to alternating aerobic and anaerobic conditions. The microbially driven Fenton reaction completely degraded 1,4-dioxane (10 mM initial concentration) in 53 h with an optimal aerobic-anaerobic cycling period of 3 h. Acetate and oxalate were detected as transient intermediates during the microbially driven Fenton degradation of 1,4-dioxane, an indication that conventional and microbially driven Fenton degradation processes follow similar reaction pathways. The microbially driven Fenton reaction provides the foundation for development of alternative in situ remediation technologies to degrade environmental contaminants susceptible to attack by HO• radicals generated by the Fenton reaction. PMID:25313646

  19. Toxic effects of 1,4-dichlorobenzene on photosynthesis in Chlorella pyrenoidosa.

    PubMed

    Zhang, Jinhua; Wang, Jie; Feng, Jia; Lv, Junping; Cai, Jin; Liu, Qi; Xie, Shulian

    2016-09-01

    1,4-Dichlorobenzene (1,4-DCB) is a common organic contaminant in water. To determine the effects of this contaminant on photosynthesis in the freshwater alga Chlorella pyrenoidosa, algal cells were treated with 1,4-DCB at different concentrations for various times, and their photosynthetic pigment contents and chlorophyll fluorescence traits were analyzed. The results showed that 1,4-DCB exerted toxic effects on photosynthesis in C. pyrenoidosa, especially at concentrations exceeding 10 mg/L. The inhibitory effects of 1,4-DCB were time- and concentration-dependent. After treatment with 1,4-DCB (≥10 mg/L), the contents of photosynthetic pigments decreased significantly, the photosystem II reaction center was irreversibly damaged, and the quantum yield of photosystem II decreased significantly. Also, there were sharp decreases in the efficiency of photosynthetic electron transport and energy conversion. Photosystem II became overloaded as the amount of excitation energy distributed to it increased. All of these events weakened the photochemical reaction, and ultimately led to serious inhibition of photosynthesis. PMID:27542668

  20. Tsunami Characteristics Along the Peru-Chile Trench: Analysis of the 2015 Mw8.3 Illapel, the 2014 Mw8.2 Iquique and the 2010 Mw8.8 Maule Tsunamis in the Near-field

    NASA Astrophysics Data System (ADS)

    Omira, R.; Baptista, M. A.; Lisboa, F.

    2016-04-01

    Tsunamis occur quite frequently following large magnitude earthquakes along the Chilean coast. Most of these earthquakes occur along the Peru-Chile Trench, one of the most seismically active subduction zones of the world. This study aims to understand better the characteristics of the tsunamis triggered along the Peru-Chile Trench. We investigate the tsunamis induced by the Mw8.3 Illapel, the Mw8.2 Iquique and the Mw8.8 Maule Chilean earthquakes that happened on September 16th, 2015, April 1st, 2014 and February 27th, 2010, respectively. The study involves the relation between the co-seismic deformation and the tsunami generation, the near-field tsunami propagation, and the spectral analysis of the recorded tsunami signals in the near-field. We compare the tsunami characteristics to highlight the possible similarities between the three events and, therefore, attempt to distinguish the specific characteristics of the tsunamis occurring along the Peru-Chile Trench. We find that these three earthquakes present faults with important extensions beneath the continent which result in the generation of tsunamis with short wavelengths, relative to the fault widths involved, and with reduced initial potential energy. In addition, the presence of the Chilean continental margin, that includes the shelf of shallow bathymetry and the continental slope, constrains the tsunami propagation and the coastal impact. All these factors contribute to a concentrated local impact but can, on the other hand, reduce the far-field tsunami effects from earthquakes along Peru-Chile Trench.

  1. Ultrafast laser-driven proton sources and dynamic proton imaging

    SciTech Connect

    Nickles, Peter V.; Schnuerer, Matthias; Sokollik, Thomas; Ter-Avetisyan, Sargis; Sandner, Wolfgang; Amin, Munib; Toncian, Toma; Willi, Oswald; Andreev, Alexander

    2008-07-15

    Ion bursts, accelerated by an ultrafast (40 fs) laser-assisted target normal sheath acceleration mechanism, can be adjusted so as to deliver a nearly pure proton beam. Such laser-driven proton bursts have predominantly a low transverse emittance and a broad kinetic spectrum suitable for continuous probing of the temporal evolution of spatially extended electric fields that arise after laser irradiation of thin foils. Fields with a strength of up to 10{sup 10} V/m were measured with a new streaklike proton deflectometry setup. The data show the temporal and spatial evolution of electric fields that are due to target charge-up and ion-front expansion following intense laser-target interaction at intensities of 10{sup 17}-10{sup 18} W/cm{sup 2}. Measurement of the field evolution is important to gain further insight into lateral electron-transport processes and the influence of field dynamics on ion beam properties.

  2. Proton-proton Scattering Above 3 GeV/c

    SciTech Connect

    A. Sibirtsev, J. Haidenbauer, H.-W. Hammer S. Krewald ,Ulf-G. Meissner

    2010-01-01

    A large set of data on proton-proton differential cross sections, analyzing powers and the double-polarization parameter A{sub NN} is analyzed employing the Regge formalism. We find that the data available at proton beam momenta from 3 GeV/c to 50 GeV/c exhibit features that are very well in line with the general characteristics of Regge phenomenology and can be described with a model that includes the {rho}, {omega}, f{sub 2}, and a{sub 2} trajectories and single-Pomeron exchange. Additional data, specifically for spin-dependent observables at forward angles, would be very helpful for testing and refining our Regge model.

  3. Measurement of the Wolfenstein parameters for proton-proton and proton-neutron scattering at 500 MeV

    SciTech Connect

    Marshall, J.A.

    1984-07-01

    Using liquid hydrogen and liquid deuterium targets respectively, forward angle (ten degrees to sixty degrees in the center of Mass) free proton-proton and quasielastic proton-proton and proton-neutron triple scattering data at 500 MeV have been obtained using the high resolution spectrometer at the Los Alamos Meson Physics Facility. The data are in reasonable agreement with recent predictions from phase shift analyses, indicating that the proton-nucleon scattering amplitudes are fairly well determined at 500 MeV. 32 references.

  4. The Structure of the Proton

    DOE R&D Accomplishments Database

    Chambers, E. E.; Hofstadter, R.

    1956-04-01

    The structure and size of the proton have been studied by means of the methods of high-energy electron scattering. The elastic scattering of electrons from protons in polyethylene has been investigated at the following energies in the laboratory system: 200, 300, 400, 500, 550 Mev. The range of laboratory angles examined has been 30 degrees to 135 degrees. At the largest angles and the highest energy, the cross section for scattering shows a deviation below that expected from a point proton by a factor of about nine. The magnitude and variation with angle of the deviations determine a structure factor for the proton, and thereby determine the size and shape of the charge and magnetic-moment distributions within the proton. An interpretation, consistent at all energies and angles and agreeing with earlier results from this laboratory, fixes the rms radius at 0.77 {plus or minus} 0.10 x 10{sup -13} cm for each of the charge and moment distributions. The shape of the density function is not far from a Gaussian with rms radius 0.70 x 10{sup -13} cm or an exponential with rms radius 0.80 x 10 {sup -13} cm. An equivalent interpretation of the experiments would ascribe the apparent size to a breakdown of the Coulomb law and the conventional theory of electromagnetism.

  5. Intramolecular Proton Transfer in Channelrhodopsins

    PubMed Central

    Sineshchekov, Oleg A.; Govorunova, Elena G.; Wang, Jihong; Li, Hai; Spudich, John L.

    2013-01-01

    Channelrhodopsins serve as photoreceptors that control the motility behavior of green flagellate algae and act as light-gated ion channels when heterologously expressed in animal cells. Here, we report direct measurements of proton transfer from the retinylidene Schiff base in several channelrhodopsin variants expressed in HEK293 cells. A fast outward-directed current precedes the passive channel current that has the opposite direction at physiological holding potentials. This rapid charge movement occurs on the timescale of the M intermediate formation in microbial rhodopsins, including that for channelrhodopsin from Chlamydomonas augustae and its mutants, reported in this study. Mutant analysis showed that the glutamate residue corresponding to Asp85 in bacteriorhodopsin acts as the primary acceptor of the Schiff-base proton in low-efficiency channelrhodopsins. Another photoactive-site residue corresponding to Asp212 in bacteriorhodopsin serves as an alternative proton acceptor and plays a more important role in channel opening than the primary acceptor. In more efficient channelrhodopsins from Chlamydomonas reinhardtii, Mesostigma viride, and Platymonas (Tetraselmis) subcordiformis, the fast current was apparently absent. The inverse correlation of the outward proton transfer and channel activity is consistent with channel function evolving in channelrhodopsins at the expense of their capacity for active proton transport. PMID:23442959

  6. Towards a proton imaging system

    NASA Astrophysics Data System (ADS)

    Civinini, C.; Brianzi, M.; Bruzzi, M.; Bucciolini, M.; Candiano, G.; Capineri, L.; Cirrone, G. A. P.; Cuttone, G.; Lo Presti, D.; Marrazzo, L.; Mazzaglia, E.; Menichelli, D.; Pieri, S.; Randazzo, N.; Sipala, V.; Stancampiano, C.; Talamonti, C.; Tesi, M.; Valentini, S.

    2010-11-01

    Hadron therapy for tumor treatment is nowadays used in several medical centres. The main advantage in using protons or light ions beams is the possibility of tightly shaping the radiation dose to the target volume. Presently the spatial accuracy of the therapy is limited by the uncertainty in stopping power distribution, which is derived, for each treatment, from the photon attenuation coefficients measured by X-ray tomography. A direct measurement of the stopping powers will help in reducing this uncertainty. This can be achieved by using a proton beam and a detection system able to reconstruct a tomography image of the patient. As a first step towards such a system an apparatus able to perform a proton transmission radiography (pCR) has been designed. It consists of a silicon microstrip tracker, measuring proton trajectories, and a YAG:Ce calorimeter to determine the particle residual energy. Proton beam and laboratory tests have been performed on the system components prototypes: the main results will be shown and discussed.

  7. Numerical studies of startup scenarios in a 1.5 MW, 110 GHz gyrotron operating in short pulses

    NASA Astrophysics Data System (ADS)

    Sinitsyn, Oleksandr; Nusinovich, Gregory; Antonsen, Thomas, Jr.; Tax, David; Temkin, Richard; Ireap, University Of Maryland Collaboration; Psfc, Massachusetts Institute Of Technology Collaboration

    2011-10-01

    Megawatt class gyrotrons operate in very high-order modes which form a very dense spectrum. In order to excite the operating mode in the presence of many competitors and drive it to the nominal operating point, careful control of the gyrotron's startup is necessary. Our studies are focused on the startup scenarios of the 110 GHz MIT gyrotron designed for operation at 1.5 MW power level in short pulses. Nominal parameters of the electron beam are: 96 kV, 42 A and orbital-to-axial velocity ratio α = 1.4. Previous numerical studies of the startup of this gyrotron had shown that at low voltages (at about 62 kV), first, the high-frequency TE23,6 mode was excited and then, at higher voltages (at about 74 kV), it was replaced by the desired TE22,6 mode. However, during a series of recent experiments at MIT it was shown that instead of the TE23,6 mode a low-frequency TE21,6 mode was excited during the voltage rise and persisted up to a voltage of 70 kV. In this work the authors make an attempt to simulate and explain this result with the help of self-consistent time-dependent code MAGY.

  8. A new zinc(II) fluorophore 2-(9-anthrylmethylamino)ethyl-appended 1,4,7,10-tetraazacyclododecane.

    PubMed

    Aoki, Shin; Kaido, Saori; Fujioka, Haruto; Kimura, Eiichi

    2003-02-24

    A new 2-(9-anthrylmethylamino)ethyl-appended cyclen, L(3) (1-(2-(9-anthrylmethylamino)ethyl)-1,4,7,10-tetraazacyclododecane) (cyclen = 1,4,7,10-tetraazacyclododecane), was synthesized and characterized for a new Zn(2+) chelation-enhanced fluorophore, in comparison with previously reported 9-anthrylmethylcyclen L(1) (1-(9-anthrylmethyl)-1,4,7,10-tetraazacyclododecane) and dansylamide cyclen L(2). L(3) showed protonation constants log K(a)(i)() of 10.57 +/- 0.02, 9.10 +/- 0.02, 7.15 +/- 0.02, <2, and <2. The log K(a3) value of 7.15 was assigned to the pendant 2-(9-anthrylmethylamino)ethyl on the basis of the pH-dependent (1)H NMR and fluorescence spectroscopic measurements. The potentiometric pH titration study indicated extremely stable 1:1 Zn(2+)-L(3) complexation with a stability constant log K(s)(ZnL(3)) (where K(s)(ZnL(3)) = [ZnL(3)]/[Zn(2+)][L(3)] (M(-)(1))) of 17.6 at 25 degrees C with I = 0.1 (NaNO(3)), which is translated into the much smaller apparent dissociation constant K(d) (=[Zn(2+)](free)[L(3)](free)/[ZnL(3)]) of 2 x 10(-)(11) M with respect to 5 x 10(-)(8) M for L(1) at pH 7.4. The quantum yield (Phi = 0.14) in the fluorescent emission of L(3) increased to Phi = 0.44 upon complexation with zinc(II) ion at pH 7.4 (excitation at 368 nm). The fluorescence of 5 microM L(3) at pH 7.4 linearly increased with a 0.1-5 microM concentration of zinc(II). By comparison, the fluorescent emission of the free ligand L(1) decreased upon binding to Zn(2+) (from Phi = 0.27 to Phi = 0.19) at pH 7.4 (excitation at 368 nm). The Zn(2+) complexation with L(3) occurred more rapidly (the second-order rate constant k(2) is 4.6 x 10(2) M(-)(1) s(-)(1)) at pH 7.4 than that with L(1) (k(2) = 5.6 x 10 M(-)(1) s(-)(1)) and L(2) (k(2) = 1.4 x 10(2) M(-)(1) s(-)(1)). With an additionally inserted ethylamine in the pendant group, the macrocyclic ligand L(3) is a more effective and practical zinc(II) fluorophore than L(1). PMID:12588134

  9. High-power proton linac for transmuting the long-lived fission products in nuclear waste

    SciTech Connect

    Lawrence, G.P.

    1991-01-01

    High power proton linacs are being considered at Los Alamos as drivers for high-flux spallation neutron sources that can be used to transmute the troublesome long-lived fission products in defense nuclear waste. The transmutation scheme being studied provides a high flux (> 10{sup 16}/cm{sup 2}{minus}s) of thermal neutrons, which efficiently converts fission products to stable or short-lived isotopes. A medium-energy proton linac with an average beam power of about 110 MW can burn the accumulated Tc99 and I129 inventory at the DOE's Hanford Site within 30 years. Preliminary concepts for this machine are described. 3 refs., 5 figs., 2 tabs.

  10. Spin models of the proton

    SciTech Connect

    Ramsey, G.P.

    1988-10-20

    We have constructed a model of the proton spin based on a broken SU(6) parameterization for the spin-weighted valence quark distributions in a longitudinally polarized proton. The polarized sea and gluon distributions are assumed to have simple relations to the corresponding unpolarized structure functions. The sum rules, which involve the non-singlet components of the structure function xg/sub 1/, imply that the valence quarks carry about 78% of the proton spin, while the spin carried by sea quarks is negative. Recent EMC data suggest a model in which the sea quarks carry a large negative polarization, whereas certain theoretical arguments favor a model with a smaller negatively polarized sea. These models are discussed with reference to the sum rules. Experiments are suggested which will discriminate between these models. 24 refs., 4 figs.

  11. The search for proton decay

    SciTech Connect

    Haines, T.; Kaneyuki, K.; McGrew, C.; Mohapatra, R.; Peterson, E.; Cline, D.B.

    1994-12-31

    The conservation of the quantum number called baryon number, like lepton (or family) number, is an empirical fact even though there are very good reasons to expect otherwise. Experimentalists have been searching for baryon number violating decays of the proton and neutron for decades now without success. Theorists have evolved deep understanding of the relationship between the natural forces in the development of various Grand Unified Theories (GUTs) that nearly universally predict baryon number violating proton decay, or related phenomena like n-{bar n} oscillations. With this in mind, the Proton Decay Working Group reviewed the current experimental and theoretical status of the search for baryon number violation with an eye to the advancement in the next decade.

  12. Polarized proton beams in RHIC

    SciTech Connect

    Zelenski, A.

    2010-10-04

    The polarized beam for RHIC is produced in the optically-pumped polarized H{sup -} ion source and then accelerated in Linac to 200 MeV for strip-injection to Booster and further accelerated 24.3 GeV in AGS for injection in RHIC. In 2009 Run polarized protons was successfully accelerated to 250 GeV beam energy. The beam polarization of about 60% at 100 GeV beam energy and 36-42% at 250 GeV beam energy was measured with the H-jet and p-Carbon CNI polarimeters. The gluon contribution to the proton spin was studied in collisions of longitudinally polarized proton beams at 100 x 100 GeV. At 250 x 250 GeV an intermediate boson W production with the longitudinally polarized beams was studied for the first time.

  13. Thermalization of pair plasma with proton loading

    SciTech Connect

    Aksenov, A. G.

    2009-05-03

    We study kinetic evolution of nonequilibrium optically thick electron-positron plasma towards thermal equilibrium solving numerically relativistic Boltzmann equations with energy per particle ranging from 0.1 to 10 MeV. We generalize our results presented in [1], considering proton loading of the pair plasma. Proton loading introduces new characteristic timescales essentially due to proton-proton and proton-electron Coulomb collisions. Taking into account not only binary but also triple direct and inverse interactions between electrons, positrons, photons and protons we show that thermal equilibrium is reached on a timescale t{sub th}{approx_equal}10{sup -11} sec.

  14. HCG induces β1,4-GalT I expression and promotes embryo implantation.

    PubMed

    Chen, Lili; Xie, Yunpeng; Fan, Jianhui; Sui, Linlin; Xu, Yuefei; Zhang, Ningning; Ma, Yanni; Li, Yinghua; Kong, Ying

    2015-01-01

    Embryo implantation is regarded as a critical physiological process for the success of pregnancy. There are so many reports on the research of human chorionic gonadotropin (HCG) in artificial insemination, but the impact of HCG on endometrial receptivity has not been elucidated. Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain. It not only transfers galactose from UDP-galactoside to GlcNAc to form Galβl,4-GlcNAc, but plays crucial role as cell adhesion molecule by recognizing and adhering other extracellular matrix and galactose of cell surface glycoprotein and glycolipid in cancer cells invasion and migration. The process of the embryos implantation is very similar to tumor invasion, so many biological factors participate in the tumor invasion also play a role in embryo implantation. We hypothesize that β1,4-GalT-I may take part in embryo implantation. In this study, we demonstrated that the over expression of β1,4-GalT-I was induced by HCG in RL95-2 cells. Moreover, the expression of some molecules, such as TIMP-1, LN and MMPs could be regulated by engineered expression of β1,4-GalT-I and therefore lead to the significantly alteration of adhesion capability of RL95-2 cells, even result in reduced adhesive ability between JAR cells and RL95-2 cells. Furthermore, our results indicated that HCG can obviously increase the EGFR signaling pathways-dependent molecular expression through β1,4-GalT-I, HCG also improved the adhesive ability between JAR cells and RL95-2 cells (P<0.01). Taken together, our data suggested that HCG provides a mechanism to bridge embryo to endometrium through β1,4-GalT. PMID:26191157

  15. HCG induces β1,4-GalT I expression and promotes embryo implantation

    PubMed Central

    Chen, Lili; Xie, Yunpeng; Fan, Jianhui; Sui, Linlin; Xu, Yuefei; Zhang, Ningning; Ma, Yanni; Li, Yinghua; Kong, Ying

    2015-01-01

    Embryo implantation is regarded as a critical physiological process for the success of pregnancy. There are so many reports on the research of human chorionic gonadotropin (HCG) in artificial insemination, but the impact of HCG on endometrial receptivity has not been elucidated. Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain. It not only transfers galactose from UDP-galactoside to GlcNAc to form Galβl,4-GlcNAc, but plays crucial role as cell adhesion molecule by recognizing and adhering other extracellular matrix and galactose of cell surface glycoprotein and glycolipid in cancer cells invasion and migration. The process of the embryos implantation is very similar to tumor invasion, so many biological factors participate in the tumor invasion also play a role in embryo implantation. We hypothesize that β1,4-GalT-I may take part in embryo implantation. In this study, we demonstrated that the over expression of β1,4-GalT-I was induced by HCG in RL95-2 cells. Moreover, the expression of some molecules, such as TIMP-1, LN and MMPs could be regulated by engineered expression of β1,4-GalT-I and therefore lead to the significantly alteration of adhesion capability of RL95-2 cells, even result in reduced adhesive ability between JAR cells and RL95-2 cells. Furthermore, our results indicated that HCG can obviously increase the EGFR signaling pathways-dependent molecular expression through β1,4-GalT-I, HCG also improved the adhesive ability between JAR cells and RL95-2 cells (P < 0.01). Taken together, our data suggested that HCG provides a mechanism to bridge embryo to endometrium through β1,4-GalT. PMID:26191157

  16. Active interrogation using energetic protons

    SciTech Connect

    Morris, Christopher L; Chung, Kiwhan; Greene, Steven J; Hogan, Gary E; Makela, Mark; Mariam, Fesseha; Milner, Edward C; Murray, Matthew; Saunders, Alexander; Spaulding, Randy; Wang, Zhehui; Waters, Laurie; Wysocki, Frederick

    2010-01-01

    Energetic proton beams provide an attractive alternative when compared to electromagnetic and neutron beams for active interrogation of nuclear threats because they have large fission cross sections, long mean free paths and high penetration, and they can be manipulated with magnetic optics. We have measured time-dependent cross sections and neutron yields for delayed neutrons and gamma rays using 800 MeV and 4 GeV proton beams with a set of bare and shielded targets. The results show significant signals from both unshielded and shielded nuclear materials. Measurements of neutron energies yield suggest a signature unique to fissile material. Results are presented in this paper.

  17. Proton interactions with high multiplicity

    SciTech Connect

    Kokoulina, E. S. Nikitin, V. A.; Petukhov, Y. P.; Kutov, A. Ya.

    2012-06-15

    Project Thermalization is aimed to study the proton-proton interaction with high multiplicity of secondary particles. The region of high multiplicity is especially actual at present. We expect the manifestation of the secondary particle collective behavior at this region. The experimentally measured topological cross section was corrected for apparatus acceptance and detection efficiency. These data are in good agreement with gluon dominance model. The comparison with other models is also done and shows no essential deviations. There is evidence that Bose-Einstein condensation can formed at high total multiplicity region.

  18. Proton aurora and substorm intensifications

    NASA Technical Reports Server (NTRS)

    Samson, J. C.; Xu, B.; Lyons, L. R.; Newell, P. T.; Creutzberg, F.

    1993-01-01

    Ground based measurements from the CANOPUS array of meridian scanning photometers and precipitating ion and electron data from the DMSP F9 satellite show that the electron arc which brightens to initiate substorm intensifications is formed within a region of intense proton precipitation that is well equatorward (approximately four to six degrees) of the nightside open-closed field line boundary. The precipitating protons are from a population that is energized via earthward convection from the magnetotail into the dipolar region of the magnetosphere and may play an important role in the formation of the electron arcs leading to substorm intensifications on dipole-like field lines.

  19. Structures of 1,4-benzodioxane derivatives from the seeds of Phytolacca americana and their neuritogenic activity in primary cultured rat cortical neurons.

    PubMed

    Takahasi, Hironobu; Yanagi, Kazue; Ueda, Masumi; Nakade, Kousuke; Fukuyama, Yoshiyasu

    2003-12-01

    The methanol extract of the seeds of Phytolacca americana was reinvestigated to yield three new 1,4-benzodioxane-type compounds, americanoic acid methyl ester (1), isoamericanoic acid A methyl ester (2), and 9'-O-methylamericanol A (3) along with the previously isolated neolignans 6-9. The structures of 1-3 were characterized by 2D NMR and long-range selective proton-decoupling (LSPD) techniques. The neuritogenic effects of compounds 1-3, and dicarboxilic acids 4 and 5, which had been previously synthesized with horseradish peroxidase-catalyzed oxidative coupling of caffeic acid, were examined in primary cultured rat cortical neurons. Americanoic acid A methyl ester (1) exhibited neurite outgrowth-promoting activity at concentration of 0.01-1.0 microM, whereas dicarboxilic acids 4 and 5 were found to induce neuritogenesis dose dependently at the concentrations from 0.1 microM to 10 microM. PMID:14646313

  20. Structural Considerations of a 20MW Multi-Rotor Wind Energy System

    NASA Astrophysics Data System (ADS)

    Jamieson, P.; Branney, M.

    2014-12-01

    The drive to upscale offshore wind turbines relates especially to possiblereductions in O&M and electrical interconnection costs per MW of installed capacity.Even with best current technologies, designs with rated capacity above about 3 MW are less cost effective exfactory per rated MW(turbine system costs) than smaller machines.Very large offshore wind turbines are thereforejustifiedprimarily by overall offshore project economics. Furthermore, continuing progress in materials and structures has been essential to avoid severe penalties in the power/mass ratio of large multi-MW machines.The multi-rotor concept employs many small rotors to maximise energy capture area withminimum systemvolume. Previous work has indicated that this can enablea very large reduction in the total weight and cost of rotors and drive trains compared to an equivalent large single rotor system.Thus the multi rotor concept may enable rated capacities of 20 MW or more at a single maintenancesite. Establishing the cost benefit of a multi rotor system requires examination of solutions for the support structure and yawing, ensuring aerodynamic losses from rotor interaction are not significant and that overall logistics, with much increased part count (more reliable components) and less consequence of single failuresare favourable. This paper addresses the viability of a support structure in respect of structural concept and likely weight as one necessary step in exploring the potential of the multi rotor concept.