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Sample records for 10-year return period

  1. Penetrating keratoplasty: indications over a 10 year period

    PubMed Central

    Al-Yousuf, N; Mavrikakis, I; Mavrikakis, E; Daya, S M

    2004-01-01

    Aims: To determine the indications for penetrating keratoplasty (PK) at the Corneoplastic Unit and Eye Bank, UK, a tertiary referral centre, over a 10 year period. Methods: Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%). Results: Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs’ endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p<0.005). Among the regraft subgroup, viral keratitis accounted for 21.2% as the underlying primary diagnosis. The most common cause for graft failure in the regraft subgroup was endothelial failure (41.8%). Conclusion: Regrafting is the leading indication for PK; viral disease—although declining—is the leading primary diagnosis. PMID:15258012

  2. Saturn's planetary period oscillations observed during 10 years of Cassini

    NASA Astrophysics Data System (ADS)

    Provan, Gabrielle; Andrews, David; Cowley, Stanley; Dougherty, Michele

    2014-05-01

    Planetary period oscillations (PPOs) with periods close to Saturn's rotational period are ubiquitous throughout Saturn's magnetospheric system. Here we review the observational studies of PPOs determined from magnetospheric magnetic field data throughout the Cassini mission to date. As first shown using radio data, two oscillatory systems are present, one associated with the northern polar region and the other with the southern. We show that within the northern (southern) open-field polar region only the northern (southern) PPO oscillations are detected. However, within the equatorial 'core' region of Saturn's magnetosphere (dipole L ≤ 12), the two oscillations are superposed and interfere. The PPO periods are shown to lie in the range ~10.6 to 10.8 h, are persistently shorter north than south to date, and undergo a strong seasonal cycle together with the oscillation amplitudes. We discuss these observations in relation to theoretical models that have been proposed to explain them, and emphasize the importance of continued measurement of their properties during the Cassini solstice mission.

  3. Sex differences in cognition are stable over a 10-year period in adulthood and old age.

    PubMed

    de Frias, Cindy M; Nilsson, Lars-Göran; Herlitz, Agneta

    2006-01-01

    Sex differences in declarative memory and visuospatial ability are robust in cross-sectional studies. The present longitudinal study examined whether sex differences in cognition were present over a 10-year period, and whether age modified the magnitude of sex differences. Tests assessing episodic and semantic memory, and visuospatial ability were administered to 625 nondemented adults (initially aged 35-80 years), participating in the population-based Betula study at two follow-up occasions. There was stability of sex differences across five age groups and over a 10-year period. Women performed at a higher level than men on episodic recall, face and verbal recognition, and semantic fluency, whereas men performed better than women on a task-assessing, visuospatial ability. Sex differences in cognitive functions are stable over a 10-year period and from 35 to 90 years of age.

  4. Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan.

    PubMed

    Ikesugi, Kengo; Ichio, Takako; Tsukitome, Hideyuki; Kondo, Mineo

    2017-07-01

    To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly defined Act on Welfare of the Physically Disabled Persons' criteria. The age, sex distribution, and causes of visual impairment were determined from the certificates. The major causes of visual impairment during the ten-year period were glaucoma (23.3%), diabetic retinopathy (17.3%), retinitis pigmentosa (12.2%), macular degeneration (9.0%), chorioretinal degeneration or high myopia (7.4%), optic atrophy (5.8%), stroke or brain tumor (5.4%) and cataracts (3.7%). The incidence of glaucoma was significantly higher throughout the period (2004-2013), and that of diabetic retinopathy was lower between 2007 and 2013. The incidence of retinitis pigmentosa did not change significantly during the 10-year period. The incidence of macular degeneration tended to increase between 2004 and 2007, but it decreased significantly between 2007 and 2013. The results indicate that in Japan, the rates of the major causes of visual impairment altered in the most recent 10-year period reflecting the recent changes in the social background and advances in ocular and systemic treatment.

  5. Injuries to elite male cricketers in Australia over a 10-year period.

    PubMed

    Orchard, John W; James, Trefor; Portus, Marc R

    2006-12-01

    This study analyses injuries occurring to Australian male cricketers at the state and national levels over 10 years using recently published international definitions of injury. Data was collected retrospectively for 3 years and then prospectively over the final 7 years. Injury incidence has stayed at a fairly constant level over the 10 years. Injury prevalence has gradually increased over the 10-year period but fell in season 2004-2005. Increasing match scheduling over the 10-year period has probably contributed to the increasing injury prevalence. Fast bowlers miss, through injury, about 16% of all potential playing time, whereas the prevalence rate for all other positions is less than 5%. Some match and schedule-related risks for bowling injury have been noted, including a greater risk of injury in the second innings of first class matches (compared to the first innings), a greater risk of injury in the second game of back-to-back matches and an increased risk of injury in the rare situation of enforcing the follow-on in a test match. The introduction of a boundary rope at all grounds has successfully eliminated the mechanism of injury from collision with fences whilst fielding. Cricket is a much safer sport to play at the elite level for batsmen, fieldsmen, wicketkeepers, and spin bowlers than the football codes, which are the other most popular professional sports in Australia.

  6. An epidemiological survey of tinea capitis in Sarajevo, Bosnia and Herzegovina over a 10-year period.

    PubMed

    Prohic, Asja

    2008-03-01

    The aim of this study was to determine the incidence and aetiological agents of tinea capitis in Sarajevo area, Bosnia and Herzegovina, during a 10-year period (1997-2006). A total of 707 patients with suspected dermatophyte infections of scalp was analysed. Tinea capitis was determined in 241 (34.1%) of these patients, in whom causative agents were identified in 209 (29.6%). Zoophilic dermatophytes (91.8%) prevailed over anthropophilic (7.2%) and geophilic (1.0%) dermatophytes. Microsporum canis was the most frequent dermatophyte isolated (90.4%), followed by Trichophyton schoenleinii (2.4%) and Trichophyton violaceum (1.9%). The majority of infections occurred in males (56.5%) and in children with age less than 10 years (52.6%).

  7. Graft survival rate of renal transplantation during a period of 10 years in Iran

    PubMed Central

    Shahbazi, Fatemeh; Ranjbaran, Mehdi; Karami-far, Simin; Soori, Hamid; Manesh, Hadi Jafari

    2015-01-01

    Background: Kidney transplantation is a preferred treatment for many patients with end-stage renal disease (ESRD) and is far more profitable than hemodialysis. Analyzing renal transplantation data can help to evaluate the effectiveness of transplantation interventions. The aim of this study was to determine the organ survival rate after kidney transplantation during a period of 10 years (March 2001-March 2011) among transplanted patients in Arak, Markazi Province, Iran. Materials and Methods: In this historical cohort study, all recipients of kidney transplantation from Arak, Markazi Province, Iran who had medical records in Valiasr Hospital and “charity for kidney patients” of Arak, Markazi Province, Iran during a period of 10 years from March 2001 to March 2011 were included. Data collected by using checklists were completed from patients’ hospital records. Kaplan-Meier method was used to determine the graft cumulative survival rate, log-rank test to compare survival curves in subgroups, and Cox regression model to define the hazard ratio and for ruling out the intervening factors. Statistical analysis was conducted by Statistical Package for the Social Sciences (SPSS) 20 and Stata 11. Results: Mean duration of follow-up was 55.43 ± 42.02 months. By using the Kaplan-Meier method, the cumulative probability of graft survival at 1, 3, 5, 7, and 10 years was 99.1, 97.7, 94.3, 85.7, and 62.1%, respectively. The number of dialysis by controlling the effect of other variables had a significant association with the risk of graft failure [hazard ratios and 95% confidence interval (CI): 1.47 (1.02-2.13)]. Conclusion: This study showed that the graft survival rate was satisfactory in this community and was similar to the results of single-center studies in the world. Dialysis time after transplantation was a significant predictor of survival in the recipients of kidney transplantation that should be considered. PMID:26941807

  8. [Epidemiology of neuroblastoma in Brittany over a 10-year period (1980-1989)].

    PubMed

    Blanchot, I; Bergeron, C; Roussey, M; De Parscau, L; Le Gall, E

    1993-01-01

    We report the results of a retrospective epidemiologic study on neuroblastoma in Brittany, a region of France characterized by an homogeneous sedentary population living on a granitic ground. During a period of 10 years (1980-1989), 48 cases of neuroblastoma were observed, which gives an incidence of 7.92 cases per million of children under 15 years. There were 25 boys and 23 girls and 20 infants under 1 year (41%). The localisation was abdominal in 39 cases (81%). Among the 28 children older than 1 year, 25 (89%) had stage III and stage IV neuroblastomas, half of them with metastases. We conclude that the incidence and the clinical presentation of neuroblastoma in Brittany are similar to those reported in other countries.

  9. Evolution of Helicobacter pylori susceptibility to antibiotics during a 10-year period in Lithuania.

    PubMed

    Kupcinskas, Limas; Rasmussen, Lone; Jonaitis, Laimas; Kiudelis, Gediminas; Jørgensen, Marianne; Urbonaviciene, Neringa; Tamosiunas, Vytas; Kupcinskas, Juozas; Miciuleviciene, Jolanta; Kadusevicius, Edmundas; Berg, Douglas; Andersen, Leif P

    2013-05-01

    The study evaluated the changes in the prevalence of Helicobacter pylori strains with primary resistance to antibiotics during the last 10 years in Lithuania. H. pylori susceptibilities to antibiotics were tested in 89 patients in 1998, in 81 patients in 2001 and in 90 patients in 2007/2008. Susceptibility to metronidazole, clarithromycin, amoxicillin and tetracycline was tested using E-test or agar dilution method. Susceptibility to ciprofloxacin was only tested in 2007/2008. Data about utilization of all authorized and available on market macrolides and clindamycin in Lithuania during 2003-2007 were evaluated using WHO ATC/DDD methodology. A total of 260 H. pylori strains cultured from untreated adult patients were investigated. Primary resistance rates (1998, 2001 and 2007/2008) for metronidazole were 24.7%, 33.3%, and 35.6%, for clarithromycin 1.1%, 3.7%, and 3.3% and for tetracycline 0%, 2.5% and 0% respectively. No cases of amoxicillin resistance have been detected. The resistance rate for ciprofloxacin was 5.6% in 2007/2008. Data of total macrolides and clarithromycin utilization in Lithuania revealed that despite an increase of consumption of these drugs in Lithuania during 2003-2007 in 1.5 times, the total macrolide consumption remains one of the lowest in Europe. We have not observed any significant changes in the susceptibility of H. pylori to the most widely used antibiotics during the recent 10-year period. The low resistance rate to clarithromycin might be related to the policy to avoid use of macrolides as first-line treatment for pulmonary and other infections. © 2012 The Authors APMIS © 2012 APMIS.

  10. Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research.

    PubMed

    Halgberg, F; Cornélissen, G; Watanabe, Y; Otsuka, K; Fiser, B; Siegelova, J; Mazankova, V; Maggioni, C; Sothern, R B; Katinas, G S; Syutkina, E V; Burioka, N; Schwrtzkopff, O

    2001-05-01

    Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then"flew blind" concerning the uncertainties associated with these cycles when they are not assessed. The resolution of more about 10-year and other cycles, some reported herein, replaces the admission of complete unpredictability, implied by using the label "secularity." Heretofore unaccounted-for variability becomes predictable insofar as it proves to be rhythmic and is mapped systematically to serve as a battery of useful reference values. About 10-year cycles in urinary 17-ketosteroid excretion and in heart rate and its variability, among others, are aligned with cycles of similar length in mortality from myocardial infarction. Associations accumulate between cycles of natural physical time structures, chronomes such as the 10.5-year (circadecennian) Schwabe and the 21-year (circavigintunennian) Hale cycles of solar activity, and chronomes in biota. There are about 50-year (circasemicentennian) cycles in mortality from stroke in Minnesota and in the Czech Republic and also in human morphology at birth, the latter result reducing the likelihood that these cycles are purely human made. Associations among large populations warrant long-term systematic coordinated sampling of natural physical and biological variables of interest for the design of countermeasures against already documented elevated risks of stroke, myocardial infarction, and other catastrophic diseases, notably in elderly adults. New findings will be introduced against the background of the documented value of mapping rhythms in medicine and gerontology. In both these fields, rhythms promise the seeming paradox of better care for less.

  11. Paediatric head injury admissions over a 10-year period in a regional neurosurgical unit.

    PubMed

    Phang, I; Mathieson, C; Sexton, I; Forsyth, S; Brown, J; St George, E J

    2012-08-01

    Traumatic brain injury is a leading cause of death and disability in childhood. A retrospective study of all paediatric head injuries admitted to the neurosurgical unit for the West of Scotland over a 10-year period was performed to assess the impact of the National Institute for Health and Clinical Excellence head injury guidelines on the admission rate and to determine the associated risk factors, causes, severity and outcomes of these injuries. There were 564 admissions between 1998 and 2007. The median age at presentation was nine years and two months. There was no change in the admission rate, injury mechanism or severity of head injury admitted over the period studied. A relationship was observed between the Scottish Index of Multiple Deprivation Score and the incidence of head injury (P = 0.05). Alcohol was reported as a causative factor in only a small number of cases, and moderate to severe head injuries were more commonly identified as a result of road traffic accidents.

  12. Iatrogenic patient injuries in otology during a 10-year period: review of national patient insurance charts.

    PubMed

    Helmiö, Päivi; Saarinen, Riitta; Aaltonen, Leena-Maija; Lehtonen, Lasse; Blomgren, Karin

    2017-09-14

    To assess patient injury characteristics and contributing factors in otology. Data on the accepted patient-injury claims involving otorhinolaryngology (ORL), closed between 2001 and 2011, from the Finnish Patient Insurance Centre registry was retrieved. We included all injuries concerning otology, with evaluation and classification of their causes and types. During the 10-year study period, a total of 44 claims were accepted as compensated patient injuries in otology. From a total of 233 patient injuries in all ORL, this amounted to 19%. In outpatient care, occurred 12 (27%) injuries and in surgical procedures 32 (73%). Five (11%) patients were children. Errors in surgical technique were identified as the primary cause of the injury in 22 (69%) operation-related cases. Failure to remove all auricular tampons or packing in postoperative control was a contributing factor in 4 (13%) injuries, a facial nerve was damaged in 9 (28%) operations, and in 12 (38%) patients, the injury resulted in severe hearing loss or deafness. Six patients (21%) needed one or more re-operations related to the injury, of which two were due to an incomplete primary operation. Typical compensated patient injuries in operative otology resulted from common complications of common operations in high volume centres.

  13. The Decline of Inpatient Penile Prosthesis over the 10-Year Period, 2000-2010.

    PubMed

    Alwaal, Amjad; Harris, Catherine R; Hussein, Ahmed A; Sanford, Thomas H; McCulloch, Charles E; Shindel, Alan W; Breyer, Benjamin N

    2015-12-01

    Culloch CE, Shindel AW, and Breyer BN. The decline of inpatient penile prosthesis over the 10-year period, 2000-2010. Sex Med 2015;3:280-286.

  14. Effect of meteorology and soil condition on metolachlor and atrazine volatilization over a 10 year period

    USDA-ARS?s Scientific Manuscript database

    Volatilization of pesticides can detrimentally affect the environment by contaminating soil and surface waters far away from where the pesticides were applied. A 10-year study was conducted to focus on the impact of soil and climatic factors governing herbicide volatilization from an agricultural f...

  15. Effect of meteorology and soil condition on metolachlor and atrazine volatilization over a 10 year period

    USDA-ARS?s Scientific Manuscript database

    A 10-year study was conducted to focus on the impact of soil and climatic factors governing herbicide volatilization from an agricultural field. For the first 5 years, metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] and atrazine [6-chloro-N-ethyl-N’-(1-methyl...

  16. Reliability, return periods, and risk under nonstationarity

    NASA Astrophysics Data System (ADS)

    Read, Laura K.; Vogel, Richard M.

    2015-08-01

    Water resources design has widely used the average return period as a concept to inform management and communication of the risk of experiencing an exceedance event within a planning horizon. Even though nonstationarity is often apparent, in practice hydrologic design often mistakenly assumes that the probability of exceedance, p, is constant from year to year which leads to an average return period To equal to 1/p; this expression is far more complex under nonstationarity. Even for stationary processes, the common application of an average return period is problematic: it does not account for planning horizon, is an average value that may not be representative of the time to the next flood, and is generally not applied in other areas of water planning. We combine existing theoretical and empirical results from the literature to provide the first general, comprehensive description of the probabilistic behavior of the return period and reliability under nonstationarity. We show that under nonstationarity, the underlying distribution of the return period exhibits a more complex shape than the exponential distribution under stationary conditions. Using a nonstationary lognormal model, we document the increased complexity and challenges associated with planning for future flood events over a planning horizon. We compare application of the average return period with the more common concept of reliability and recommend replacing the average return period with reliability as a more practical way to communicate event likelihood in both stationary and nonstationary contexts.

  17. Students' attitudes towards and use of computer-assisted learning in oral radiology over a 10-year period.

    PubMed

    Wenzel, A; Gotfredsen, E

    1997-03-01

    To compare the attitudes towards CAL of today's dental students with those 10 years ago and to assess the use of CAL over a 10-year period. A questionnaire was given to 40 current dental students containing 15 identical questions to those asked 10 years previously. Attitudes were ranked on a scale from 1 (worst) to 5 (best). Over the entire period, 420 students (mean = 42 students/year, range 33-56) used the programs. The material consisted of interactive computer-based teaching programs on: intraoral radiography, X-ray density and sharpness, basic radiation physics, radiation biology, X-ray apparatus and a multiple choice bank. A central computer served the PCs which the students could use as they required. Each program start was recorded at the server. Due to rebuilding and change of server, no data were sampled during 7 months of 1991. Overall, there was no statistically significant difference (P > 0.05) between students' attitudes in 1996 and 1985. Two questions were scored significantly higher in 1996. The programs were run 12,269 times in the 10-year period. Use of the programs increased steadily whereas number of dental students/year decreased. Program runs in each year, expressed as percentage (in brackets) of total runs over the 10-year period, were: 1986 (1), '87 (8), '88 (8), '89 (11), '90 (9), '91 (3), '92 (13), '93 (13), '94 (16), '95 (18). The favourable attitudes seen 10 years ago when CAL was initiated could not be ascribed to a Hawthorne effect as similarly or more favourable attitudes were recorded in 1996. Though not mandatory, CAL was frequently and increasingly used by dental students over the 10-year period.

  18. Hostility, Anger and Depression Predict Increases in C3 over a 10-Year Period

    PubMed Central

    Boyle, Stephen H.; Jackson, William G.; Suarez, Edward C.

    2007-01-01

    We examined the relation of hostility, anger and depression to 10-year changes in the third (C3) and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health consequences of dioxin exposure. Hostility, depression and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997 and 2002. Regression analyses controlling for age, race, alcohol use, body mass index and cigarette use as well as onset of disease and use of lipid lowering and blood pressure medications during follow-up revealed a significant time X composite score interaction for C3 complement (p < .0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease. PMID:17321106

  19. Hostility, anger, and depression predict increases in C3 over a 10-year period.

    PubMed

    Boyle, Stephen H; Jackson, William G; Suarez, Edward C

    2007-08-01

    We examined the relation of hostility, anger, and depression to 10-year changes in the third (C3), and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health consequences of dioxin exposure. Hostility, depression, and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger, and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997, and 2002. Regression analyses controlling for age, race, alcohol use, body mass index, and cigarette use as well as onset of disease, and use of lipid lowering and blood pressure medications during follow-up revealed a significant timexcomposite score interaction for C3 complement (p<.0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger, and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease.

  20. The cost-effectiveness of large amalgam and crown restorations over a 10-year period.

    PubMed

    Kolker, Justine L; Damiano, Peter C; Flach, Stephen D; Bentler, Suzanne E; Armstrong, Steven R; Caplan, Daniel J; Kuthy, Raymond A; Warren, John J; Jones, Michael P; Dawson, Deborah V

    2006-01-01

    To assist clinical decision making for an individual patient or on a community level, this study was done to determine the differences in costs and effectiveness of large amalgams and crowns over 5 and 10 years when catastrophic subsequent treatment (root canal therapy or extraction) was the outcome. Administrative data for patients seen at the University of Iowa, College of Dentistry for 1735 large amalgam and crown restorations in 1987 or 1988 were used. Annual costs and effectiveness values were calculated. Costs of initial treatment (large amalgam or crown), and future treatments were determined, averaged and discounted. The effectiveness measure was defined as the number of years a tooth remained in a state free of catastrophic subsequent treatment. Years free of catastrophic treatment were averaged, and discounted. The years free of catastrophic treatment accounted for individuals who dropped out or withdrew from the study. Teeth with crowns had higher effectiveness values at a much higher cost than teeth restored with large amalgams. The cost of an addition year free of catastrophic treatment for crowns was 1088.41 dollars at 5 years and 500.10 dollars at 10 years. Teeth in women had more favorable cost-effectiveness ratios than those in men, and teeth in the maxillary arch had more favorable cost-effectiveness ratios than teeth in the mandibular arch. Neither the large amalgam or crown restoration had both the lowest cost and the highest effectiveness. The higher incremental cost-effectiveness ratio for crowns should be considered when making treatment decisions between large amalgam and crown restorations.

  1. Sphenoid sinus fungall ball: a retrospective study over a 10- year period.

    PubMed

    Eloy, Ph; Grenier, J; Pirlet, A; Poirrier, A L; Stephens, J S; Rombaux, Ph

    2013-06-01

    A fungal ball consists of a dense conglomerate of fungal hyphae growing at the surface of the sinus mucosa without tissue infiltration. The maxillary sinus is by far the most commonly involved paranasal sinus cavity followed by the sphenoid sinus. The present study is a retrospective study of 25 consecutive cases treated during the last 10 years in the two hospitals be- longing to the Catholic University of Louvain (CHU Mont-Godinne and UCL Saint Luc). We report the symptomatology, the imaging and discuss the different surgical managements. We conclude that the clinician must have a high index of suspicion when dealing with a unilateral rhinosinusitis persisting despite a maximal and well conducted medical treatment. This is particularly so in elderly women when associated with facial pain and post nasal drip, particularly when the computed tomography shows an unilateral opacity of the sphenoid sinus with or without a sclerosis or an erosion of the bony walls, a polyp in the sphenoethmoidal recess or a hyperdensity mimicking a foreign body. An endonasal endoscopic sphenoidotomy is the treatment of choice in most cases, allowing good ventilation of the sinus and radical removal of all the fungal concretion. A biopsy of the sinus mucosa adjacent to fungal elements is of upmost important to confirm the non- invasiveness of the fungi within the tissue. Antifungal medication is not required in uncomplicated forms. All host factors producing some degree of immunosuppression must be corrected when present and must alert the clinician to rule out any forms of invasive disease.

  2. Pregnancy-associated listeriosis: clinical characteristics and geospatial analysis of a 10-year period in Israel.

    PubMed

    Elinav, Hila; Hershko-Klement, Anat; Valinsky, Lea; Jaffe, Josef; Wiseman, Anat; Shimon, Hila; Braun, Eyal; Paitan, Yossi; Block, Colin; Sorek, Rotem; Nir-Paz, Ran

    2014-10-01

    Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or a preterm delivery, and the neonate is prone to neonatal sepsis and death. We created a cohort of all L. monocytogenes cases during 10 years (1998-2007) in Israel, by a comprehensive review of cases in hospitals throughout the country and cases reported to the Ministry of Health. One hundred sixty-six pregnancy-related listeriosis cases were identified, resulting in a yearly incidence of 5-25 cases per 100 000 births. Presentation associated with fetal demise was more common in the second trimester (55.3%), and preterm labor (52.3%) and abnormal fetal heart rate monitoring (22.2%) were more common in the third trimester (P = .001). Fetal viability was low in the second trimester (29.2%) and much higher (95.3%) in the third trimester. Each additional week of pregnancy increased the survival chance by 33% (odds ratio, 1.331 [95% confidence interval, 1.189-1.489]). A single case of maternal mortality was identified. Listeria monocytogenes serotype 4b was more common in pregnancy-related than in non-pregnancy-related cases (79.5% vs 61.3%, P = .011). Pulsed-field gel electrophoresis analysis suggested that 1 pulsotype is responsible for 35.7% of the pregnancy cases between 2001 and 2007. This clone is closely related to the Italian gastroenteritis-associated HPB2262 and the invasive US Scott A L. monocytogenes strains. Our survey emphasizes the high rate of pregnancy-related listeriosis in Israel and shows that specific clones might account for this. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. [Congenital heart disease mortality in Spain during a 10 year period (2003-2012)].

    PubMed

    Pérez-Lescure Picarzo, Javier; Mosquera González, Margarita; Latasa Zamalloa, Pello; Crespo Marcos, David

    2017-07-12

    Congenital heart disease is a major cause of infant mortality in developed countries. In Spain, there are no publications at national level on mortality due to congenital heart disease. The aim of this study is to analyse mortality in infants with congenital heart disease, lethality of different types of congenital heart disease, and their variation over a ten-year period. A retrospective observational study was performed to evaluate mortality rate of children under one year old with congenital heart disease, using the minimum basic data set, from 2003 to 2012. Mortality rate and relative risk of mortality were estimated by Poisson regression. There were 2,970 (4.58%) infant deaths in a population of 64,831 patients with congenital heart disease, with 73.8% of deaths occurring during first week of life. Infant mortality rate in patients with congenital heart disease was 6.23 per 10,000 live births, and remained constant during the ten-year period of the study, representing 18% of total infant mortality rate in Spain. The congenital heart diseases with highest mortality rates were hypoplastic left heart syndrome (41.4%), interruption of aortic arch (20%), and total anomalous pulmonary drainage (16.8%). Atrial septal defect (1%) and pulmonary stenosis (1.1%) showed the lowest mortality rate. Congenital heart disease was a major cause of infant mortality with no variations during the study period. The proportion of infants who died in our study was similar to other similar countries. In spite of current medical advances, some forms of congenital heart disease show very high mortality rates. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  4. [Resistance phenotypes and genotypes of Streptococcus pyogenes clinical isolates in Chile over a 10-year period].

    PubMed

    Rodríguez, Carlos; Rojas, Pablo; Wozniak, Aniela; Kalergis, Alexis M; Cerón, Inés; Riedel, Ingrid; Román, Juan C; Villarroel, Luis A; Berríos, Ximena; Bavestrello, Luis; García, Patricia

    2011-09-01

    Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one. To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005. Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes. Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype. Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.

  5. Complications of chronic otitis media with cholesteatoma during a 10-year period in Kosovo.

    PubMed

    Mustafa, A; Heta, A; Kastrati, B; Dreshaj, Sh

    2008-12-01

    We review and discuss the results of treatments for complications of cholesteatomatous chronic otitis media (CCOM) in a tertiary health care center. In a retrospective study, the medical records of patients with complications of CCOM who had undergone surgical treatment at the ENT Clinic of the University Clinical Center of Kosovo for the period 1994-2004 were reviewed. From a total of 1,803 patients suffering from CCOM, in 91 patients, 55 (60.4%) men and 36 (39.6) women, one or two complications are recorded. The mean age of the subjects was 30 years, and the age range was from 1 to 76 years. Extracranial (EC) complications were observed in 52 cases (57.1%), and intracranial (IC) complications were seen in 29 patients (31.9%). Twelve patients (11%) had multiple complications. For the EC cases, we found that subperiostal mastoidal abscess occurred in 26% of the all patients, facial nerve palsy was seen in 16.48% and labyrinthine fistula occurred in 10%. For the IC cases, meningitis (19.7%) and perisinusal abscess (15.3%) were the most common complications. The most often isolated pathogen from ear swabs was Proteus mirabilis in 33.3% of cases. The most frequent radiological diagnostic procedures were mastoid tip X-rays, which were performed in 77% of the patients, and computed tomography in 24%; magnetic resonance imaging was not performed on any of the patients during the study period. Patients with EC complications were treated in the ENT Clinic, whereas patients with IC complications, after otologic surgical procedures, were transferred to the Neurosurgery Clinic or to the Clinic for Infectious Diseases. In this series, three patients (3.3%) died as a result of complications, while the remaining 96.7% survived. Complications of COM with cholesteatoma can represent life-threatening conditions, and close cooperation between otosurgeons, neurosurgeons and infectious disease specialists is mandatory.

  6. Cytologic diagnosis of coccidioidomycosis: Spectrum of findings in Southern Arizona patients over a 10 year period.

    PubMed

    Aly, F Zahra; Millius, Rebecca; Sobonya, Richard; Aboul-Nasr, Khalid; Klein, Robert

    2016-03-01

    The largest series examining the cytological diagnosis of coccidioidomycosis was reported more than 20 years ago and only considered fine needle aspiration (FNA) specimens from pulmonary nodules. Since then, there has been a substantial increase in the incidence of the disease in endemic regions. The aims of this study were to examine the spectrum of Coccidioides in all cytologic specimens and detail their diagnostic and clinical features. The prevalence of infection is also examined against temperature and precipitation data. The Department of Pathology database was retrospectively searched for cases diagnosed as coccidioidomycosis. Climate report was obtained from National Weather Service Forecast Office. Statistical analysis was carried out using JMP version 11.2.0. The presence of Coccidiodes was microscopically diverse with immature spherules, variably sized spherules, endosporulating spherules, empty spherules, and ruptured spherules being observed. Bronchoalveolar lavages demonstrated the greatest number of different forms of Coccidioides and were associated with acute inflammatory response. Granulomas were rare and mostly seen in lymph nodes and extra pulmonary sites. A necrotic background with paucity of inflammation was frequently seen in lung FNA. Immune competent patients outnumbered immunocompromised patients, illustrating the importance of considering the diagnosis in all patients. The reported association between rainfall and peak prevalence was not observed in our study. Coccidioides has diverse cytological appearance and varied host response depending on the site and type of preparation examined. In endemic areas, the disease should be considered in all patients, independent of immune status, and throughout the year. © 2016 Wiley Periodicals, Inc.

  7. 27 CFR 41.113 - Return periods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Return periods. 41.113 Section 41.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... revised, effective Feb. 22, 2011 through Feb. 24, 2014. ...

  8. Processes of physical change to the seabed and bivalve recruitment over a 10-year period following experimental hydraulic clam dredging on Banquereau, Scotian Shelf

    NASA Astrophysics Data System (ADS)

    Gilkinson, K.; King, E. L.; Li, M. Z.; Roddick, D.; Kenchington, E.; Han, G.

    2015-01-01

    A previous study on the effects of experimental hydraulic clam dredging on seabed habitat and commercial bivalve populations revealed a lack of recovery after a 3-year post-dredging period (1998-2001) on a deep (65-75 m) offshore sandy bank on the Scotian Shelf, Canada. Follow-up sidescan sonar surveys were carried out 5 and 10 years after dredging (2003, 2008) in order to identify long-term processes of seabed recovery. Grab sampling was carried out 10 years after dredging to identify post-dredging commercial bivalve recruitment. Changes in the seafloor, including dredge tracks, were documented with a series of 7 sidescan sonar surveys between 1998 and 2008. A sediment mobility model was constructed based on modeled tidal current and hindcast wave data over this time period to quantify natural seabed disturbance and interpret changes to the dredge tracks mapped by sidescan sonar surveys. The model indicated that tidal currents had minimal effect on sediment mobilization. The main driving force associated with re-working of surficial sediments as evidenced by deterioration of dredge tracks in sonograms was annual fall/winter storms. While the annual frequency of storms and associated wave heights was variable, the observations and sediment mobility calculations suggest that the most influential variable is the magnitude of individual large storms, specifically storms with a significant wave height of ∼11 m. These storms are capable of generating mobile sediment layers of 20-30 cm thickness, equivalent to the dredge blade cutting depth. It appears that, with minor exceptions, sediment properties have returned to pre-dredging conditions 10 years after dredging in this habitat. Based on known age-length relationships, the four commercial bivalve species showed very low recruitment at the experimental site over the 10-year post-dredging period. However, this is unlikely due to a dredging effect since a similar pattern was observed in non-dredged areas.

  9. Posterior implant single-tooth replacement and status of adjacent teeth during a 10-year period: a retrospective report.

    PubMed

    Misch, Carl E; Misch-Dietsh, Francine; Silc, Jennifer; Barboza, Eliane; Cianciola, Louis J; Kazor, Christopher

    2008-12-01

    The purpose of this case series study was to evaluate posterior single-tooth implant survival and the long-term conditions of the adjacent teeth. A retrospective evaluation of 1,162 consecutive patients with a single missing posterior tooth treated with 1,377 external hex implants supporting 1,365 restorations surrounded by natural teeth over a 1- to 10-year period was reviewed from four private offices. Implant survival data were collected relative to stage I to stage II healing, stage II to prosthesis delivery, and prosthesis delivery to up to 10 years of follow-up. Long-term adjacent tooth conditions were assessed, including decay, endodontic therapy (root canal therapy [RCT]), and/or extraction during the follow-up period. Of the 1,377 implants inserted, there were 11 surgical failures from stage I to stage II healing. There was one failure from stage II healing to prosthesis delivery. There were two prosthetic-phase failures. The surgical success rate was 99.2%, whereas the overall survival rate was 98.9% at an average of 61 months of follow-up (range, 12 to 125 months). A total of 2,589 adjacent teeth were followed during the study. No natural adjacent tooth was lost during this period. Interproximal decay developed in 129 adjacent teeth (5%), and nine adjacent teeth required RCT (0.4%) as a result of decay or restoration. The use of single-tooth implants as replacements for posterior missing teeth is a viable long-term treatment. Adjacent natural teeth complications are minimal for as long as 10 years after implant insertion.

  10. Epidemiology and risk factors for nosocomial bloodstream infections in solid organ transplants over a 10-year period.

    PubMed

    Berenger, B M; Doucette, K; Smith, S W

    2016-04-01

    Bloodstream infections (BSIs) are a leading cause of morbidity and mortality in solid organ transplantation (SOT). We sought to determine the types of nosocomial BSIs and risk factors for them in SOT. Prospectively collected databases of all SOT and nosocomial BSIs occurring at our institution for a 10-year period were reviewed. From 2003-2012, we observed 157 nosocomial BSI episodes in 2257 SOTs, the majority of which were caused by staphylococci and enterococci (67.5%). The most common sources of BSI were central line, organ space, respiratory, and gastrointestinal. Kidney transplant patients had the lowest risk of acquiring a BSI compared with other SOT types. Lung transplant patients were at increased risk of methicillin-resistant Staphylococcus aureus BSI and heart transplant patients were at increased risk of a Candida albicans BSI, when compared to other organ transplant types. When coagulase-negative Staphylococcus (CoNS) or C. albicans was isolated, the central line was most often the source. The implementation of central-line bundles during the study period correlated temporally with a decreased rate of CoNS BSI. Over the 10-year period, vancomycin-resistant enterococci became the most common enterococcal BSI. Donor-positive cytomegalovirus status was associated with an increased risk of BSI, when compared to donor-negative patients. This study demonstrates the common sources, risk factors, and causative organisms of BSI, which can guide empiric antibiotic choices, and highlights areas where preventative interventions could be targeted to prevent nosocomial BSI in SOT. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Examining job tenure and lost-time claim rates in Ontario, Canada, over a 10-year period, 1999-2008.

    PubMed

    Morassaei, Sara; Breslin, F Curtis; Shen, Min; Smith, Peter M

    2013-03-01

    We sought to examine the association between job tenure and lost-time claim rates over a 10-year period in Ontario, Canada. Data were obtained from workers' compensation records and labour force survey data from 1999 to 2008. Claim rates were calculated for gender, age, industry, occupation, year and job tenure group. A multivariate analysis and examination of effect modification were performed. Differences in injury event and source of injury were also examined by job tenure. Lost-time claim rates were significantly higher for workers with shorter job tenure, regardless of other factors. Claim rates for new workers differed by gender, age and industry, but remained relatively constant at an elevated rate over the observed time period. This study is the first to examine lost-time claim rates by job tenure over a time period during which overall claim rates generally declined. Claim rates did not show a convergence by job tenure. Findings highlight that new workers are still at elevated risk, and suggest the need for improved training, reducing exposures among new workers, promoting permanent employment, and monitoring work injury trends and risk factors.

  12. Association of Poor Subjective Sleep Quality With Risk for Death by Suicide During a 10-Year Period

    PubMed Central

    Bernert, Rebecca A.; Turvey, Carolyn L.; Conwell, Yeates; Joiner, Thomas E.

    2014-01-01

    IMPORTANCE Older adults have high rates of sleep disturbance, die by suicide at disproportionately higher rates compared with other age groups, and tend to visit their physician in the weeks preceding suicide death. To our knowledge, to date, no study has examined disturbed sleep as an independent risk factor for late-life suicide. OBJECTIVE To examine the relative independent risk for suicide associated with poor subjective sleep quality in a population-based study of older adults during a 10-year observation period. DESIGN, SETTING, AND PARTICIPANTS A longitudinal case-control cohort study of late-life suicide among a multisite, population-based community sample of older adults participating in the Established Populations for Epidemiologic Studies of the Elderly. Of 14 456 community older adults sampled, 400 control subjects were matched (on age, sex, and study site) to 20 suicide decedents. MAIN OUTCOMES AND MEASURES Primary measures included the Sleep Quality Index, the Center for Epidemiologic Studies–Depression Scale, and vital statistics. RESULTS Hierarchical logistic regressions revealed that poor sleep quality at baseline was significantly associated with increased risk for suicide (odds ratio [OR], 1.39; 95% CI, 1.14-1.69; P < .001) by 10 follow-up years. In addition, 2 sleep items were individually associated with elevated risk for suicide at 10-year follow-up: difficulty falling asleep (OR, 2.24; 95% CI, 1.27-3.93; P < .01) and nonrestorative sleep (OR, 2.17; 95% CI, 1.28-3.67; P < .01). Controlling for depressive symptoms, baseline self-reported sleep quality was associated with increased risk for death by suicide (OR, 1.30; 95% CI, 1.04-1.63; P < .05). CONCLUSIONS AND RELEVANCE Our results indicate that poor subjective sleep quality is associated with increased risk for death by suicide 10 years later, even after adjustment for depressive symptoms. Disturbed sleep appears to confer considerable risk, independent of depressed mood, for the most

  13. Substance Use Disorders in Elderly Admissions to an Academic Psychiatric Inpatient Service over a 10-Year Period

    PubMed Central

    Dombrowski, Dennis; Norrell, Nelly

    2016-01-01

    Objective. There is a paucity of research on substance use disorders (SUDs) in the elderly psychiatric population. This study examines SUDs in a geriatric psychiatry inpatient service over a 10-year period. Methods. Data from 1788 elderly psychiatric inpatients from a ten-year period was collected. Variables collected included psychiatric diagnoses, SUD, number of psychiatric admissions, and length of stay. Those with and without a SUD were compared using Chi-Square or Student's t-test as appropriate using SPSS. Results. 11.7% (N = 210) of patients had a SUD, and the most common substance was alcohol at 73.3% (N = 154) or 8.6% of all admissions. Other SUDs were sedative-hypnotics (11%), opiate (2.9%), cannabis (1%), tobacco (1.4%), and unspecified SUD (38.6%). SUD patients were significantly younger, divorced, male, and less frequently readmitted and had shorter lengths of stay. The most common comorbid diagnoses were major depression (26.1%), bipolar disorder (10.5%), and dementia (17.1%). Conclusions. Over 10% of psychogeriatric admissions were associated with a SUD, with alcohol being the most common. Considering the difficulties in diagnosing SUD in this population and the retrospective study design, the true prevalence in elderly psychiatric inpatients is likely higher. This study adds to sparse literature on SUD in elderly psychiatric patients. PMID:27840765

  14. Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period.

    PubMed

    Jarow, Jonathan P; Lemery, Steven; Bugin, Kevin; Khozin, Sean; Moscicki, Richard

    2016-11-01

    The purpose of this study was to describe the experience of the Center of Drug Evaluation and Research (CDER) with expanded access of investigational drugs. Multiple searches of CDER's document tracking system were performed to identify the number, type, and indication for all expanded access requests over the 10-year time period of January 2005 through December 2014. An additional search was performed to identify all active commercial investigational drug development programs during that time period and whether or not the clinical program was placed on hold. The two searches were then cross-referenced to identify those commercial investigational drug development programs placed on clinical hold due to serious adverse events occurring within expanded access programs. CDER receives over 1000 applications for expanded access each year. The majority are for single patients, roughly evenly split between emergency and nonemergency use. The vast majority, 99.7%, are allowed to proceed. The incidence of clinical holds for all commercial investigational drug development programs is 7.9%, as compared to only 0.2% related to adverse events observed in patients receiving drug treatments under expanded access. The expanded access program is viewed as a success from FDA's perspective based on the large number of applications processed and allowed to proceed each year. However, the actual number of patients and their health care providers that desire drug treatments available under expanded access is not known. It is exceedingly rare for a serious adverse event under expanded access to affect the development program for that drug.

  15. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients.

    PubMed

    Cervera, R; Serrano, R; Pons-Estel, G J; Ceberio-Hualde, L; Shoenfeld, Y; de Ramón, E; Buonaiuto, V; Jacobsen, S; Zeher, M M; Tarr, T; Tincani, A; Taglietti, M; Theodossiades, G; Nomikou, E; Galeazzi, M; Bellisai, F; Meroni, P L; Derksen, R H W M; de Groot, P G D; Baleva, M; Mosca, M; Bombardieri, S; Houssiau, F; Gris, J-C; Quéré, I; Hachulla, E; Vasconcelos, C; Fernández-Nebro, A; Haro, M; Amoura, Z; Miyara, M; Tektonidou, M; Espinosa, G; Bertolaccini, M L; Khamashta, M A

    2015-06-01

    To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations with those that appeared later. In 1999, we started an observational study of 1000 APS patients from 13 European countries. All had medical histories documented when entered into the study and were followed prospectively during the ensuing 10 years. 53.1% of the patients had primary APS, 36.2% had APS associated with systemic lupus erythematosus and 10.7% APS associated with other diseases. Thrombotic events appeared in 166 (16.6%) patients during the first 5-year period and in 115 (14.4%) during the second 5-year period. The most common events were strokes, transient ischaemic attacks, deep vein thromboses and pulmonary embolism. 127 (15.5%) women became pregnant (188 pregnancies) and 72.9% of pregnancies succeeded in having one or more live births. The most common obstetric complication was early pregnancy loss (16.5% of the pregnancies). Intrauterine growth restriction (26.3% of the total live births) and prematurity (48.2%) were the most frequent fetal morbidities. 93 (9.3%) patients died and the most frequent causes of death were severe thrombosis (36.5%) and infections (26.9%). Nine (0.9%) cases of catastrophic APS occurred and 5 (55.6%) of them died. The survival probability at 10 years was 90.7%. Patients with APS still develop significant morbidity and mortality despite current treatment. It is imperative to increase the efforts in determining optimal prognostic markers and therapeutic measures to prevent these complications. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. The incidence and severity of IgA vasculitis with nephritis over a 10-year period in our hospital.

    PubMed

    Yamane, Keishi; Kawasaki, Yukihiko; Maeda, Ryo; Ohara, Shinichiro; Suyama, Kazuhide; Hosoya, Mitsuaki

    2017-09-14

    To evaluate the recent frequency of onset and severity of IgA vasculitis with nephritis (IgAVN) in Fukushima Prefecture, we examined the epidemiology and clinico-pathological manifestations of IgAVN in our hospital over a 10-year period. We enrolled 18 patients with IgAVN treated between 2004 and 2013 in the Department of Pediatrics, Fukushima Medical University School of Medicine. These patients were divided into two groups; Group 1 consisted of 12 patients with IgAVN hospitalized between 2004 and 2008 and Group 2 consisted of 6 patients with IgAVN hospitalized between 2009 and 2013. The epidemiology, clinical features, laboratory data, pathological findings, and outcome were retrospectively compared between the two groups. The numbers of patients with IgAVN per year in Group 2 were lower than that in Group 1. The frequency of patients with higher than grade IIIb disease in Group 2 (50%) was lower than that in Group 1 (94%); furthermore, the frequency of patients with higher than grade IV disease in Group 2 (0%) was lower than that in Group 1 (50%). Our findings suggest that the incidence of onset and severity of IgAVN in patients diagnosed between 2009 and 2013 were lower than those in patients diagnosed between 2004 and 2008.

  17. Bibliometric analysis of scientific articles published in Brazilian and international orthodontic journals over a 10-year period.

    PubMed

    Primo, Neudí Antonio; Gazzola, Vivian Bertoglio; Primo, Bruno Tochetto; Tovo, Maximiano Ferreira; Faraco, Italo Medeiros

    2014-01-01

    This study aimed at describing the profiles of Brazilian and international studies published in orthodontic journals. The sample comprised 635 articles selected from two scientific journals, i.e., Dental Press Journal of Orthodontics and American Journal of Orthodontics and Dentofacial Orthopedics, which were analyzed at three different intervals over a 10-year period (1999 - 2004 - 2009). Articles were described in terms of knowledge domain, study design, and country of origin (or state of origin for Brazilian papers). The most frequent study designs adopted in international studies were cohort (23.9%) and cross-sectional (21.7%) designs. Among Brazilian papers, cross-sectional studies (28.9%) and literature reviews (24.6%) showed greater frequency. The topics most often investigated in international articles were dental materials (17%) and treatment devices (12.4%), with the latter topic being addressed by 16% of the Brazilian publications, followed by malocclusion, with 12.6%. In all cases, the most frequent countries of origin coincided with the countries of origin of each journal. The majority of the studies analyzed featured a low level of scientific evidence. Moreover, the findings showed that journals tend to publish studies produced in their own country of origin, and that there are marked discrepancies in the number of papers published by different Brazilian states.

  18. Bibliometric analysis of scientific articles published in Brazilian and international orthodontic journals over a 10-year period

    PubMed Central

    Primo, Neudí Antonio; Gazzola, Vivian Bertoglio; Primo, Bruno Tochetto; Tovo, Maximiano Ferreira; Faraco Junior, Italo Medeiros

    2014-01-01

    Objective This study aimed at describing the profiles of Brazilian and international studies published in orthodontic journals. Methods The sample comprised 635 articles selected from two scientific journals, i.e., Dental Press Journal of Orthodontics and American Journal of Orthodontics and Dentofacial Orthopedics, which were analyzed at three different intervals over a 10-year period (1999 - 2004 - 2009). Articles were described in terms of knowledge domain, study design, and country of origin (or state of origin for Brazilian papers). Results The most frequent study designs adopted in international studies were cohort (23.9%) and cross-sectional (21.7%) designs. Among Brazilian papers, cross-sectional studies (28.9%) and literature reviews (24.6%) showed greater frequency. The topics most often investigated were dental materials (17%) and treatment devices (12.4%) in international articles, with the latter topic being addressed by 16% of the Brazilian publications, followed by malocclusion, with 12.6%. In all cases, the most frequent countries of origin coincided with the countries of origin of each journal. Conclusions The majority of the studies analyzed featured a low level of scientific evidence. Moreover, the findings showed that journals tend to publish studies produced in their own country of origin, and that there are marked discrepancies in the number of papers published by different Brazilian states. PMID:24945515

  19. Changes in Active Commuting to School in Czech Adolescents in Different Types of Built Environment across a 10-Year Period

    PubMed Central

    Dygrýn, Jan; Mitáš, Josef; Gába, Aleš; Rubín, Lukáš; Frömel, Karel

    2015-01-01

    Active commuting (AC) to school represents a great opportunity to incorporate walking or cycling into adolescents’ everyday routine. The objective of the study was to describe changes in AC in Czech adolescents across a 10-year period in different built environments. Data from the 2001 and 2011 Czech Census of Population and Housing were used to examine the mode of transportation taken to school in 6236 adolescents. Changes in AC over time were analyzed for low and high walkable areas separately in two Czech regional cities, Olomouc and Hradec Králové. Between 2001 and 2011, the proportion of adolescents actively commuting to school decreased by 47%, from an absolute rate of 49.1% to 26%. The proportion of active commuters fell in low walkable areas by 61% and in high walkable areas by 39%. The results indicated that adolescents in 2011 were 2.7 times less (OR = 0.365, p < 0.001) likely to actively commute than in 2001. The AC behavior in Czech adolescents has a negative tendency to replicate travel-to-school patterns in adolescents previously described in more developed countries. The findings might serve as a recommendation for municipal policy. PMID:26501304

  20. Changes in Active Commuting to School in Czech Adolescents in Different Types of Built Environment across a 10-Year Period.

    PubMed

    Dygrýn, Jan; Mitáš, Josef; Gába, Aleš; Rubín, Lukáš; Frömel, Karel

    2015-10-16

    Active commuting (AC) to school represents a great opportunity to incorporate walking or cycling into adolescents' everyday routine. The objective of the study was to describe changes in AC in Czech adolescents across a 10-year period in different built environments. Data from the 2001 and 2011 Czech Census of Population and Housing were used to examine the mode of transportation taken to school in 6236 adolescents. Changes in AC over time were analyzed for low and high walkable areas separately in two Czech regional cities, Olomouc and Hradec Králové. Between 2001 and 2011, the proportion of adolescents actively commuting to school decreased by 47%, from an absolute rate of 49.1% to 26%. The proportion of active commuters fell in low walkable areas by 61% and in high walkable areas by 39%. The results indicated that adolescents in 2011 were 2.7 times less (OR = 0.365, p < 0.001) likely to actively commute than in 2001. The AC behavior in Czech adolescents has a negative tendency to replicate travel-to-school patterns in adolescents previously described in more developed countries. The findings might serve as a recommendation for municipal policy.

  1. Phytoplankton succession in a coastal area of the NW Adriatic, over a 10-year sampling period (1990-1999)

    NASA Astrophysics Data System (ADS)

    Aubry, F. Bernardi; Berton, A.; Bastianini, M.; Socal, G.; Acri, F.

    2004-01-01

    The distribution of phytoplankton abundance and species composition is described for coastal waters of the NW Adriatic Sea, for the period 1990-1999. Hydrochemical and biological properties were investigated every month, at 48 stations. This coastal system is quite unstable and heterogeneous, due to the influence of several rivers, intense water exchange with the Lagoon of Venice, and complex advective processes. In the vicinity of river plumes, dissolved nitrogen and dissolved silica appear to be in excess, rarely limiting phytoplankton growth. Examining the general trend of phytoplankton over the years, the main limiting factors for phytoplankton growth in the Adriatic coastal system are light, temperature, and the strong influence of meteorological events. The NW Adriatic coastal area was subdivided into three zones, each characterised by different trophic conditions. In each zone, phytoplankton was similar in terms of community structure and was different only in abundance. Three main periods of growth were observed: February, April and July. As expected in a nutrient-enriched system, the community structure was dominated by diatoms (both micro- and nanoplankton fractions), over most of the year. The importance of dinoflagellates in the communities was generally low, with significant abundances present only in June-July, once the spring bloom of diatoms had left 'nutrient-poor' conditions in the water. These low concentrations of nutrients favoured the growth of dinoflagellates, which have lower nutritional requirements. Over the 10-year study, a decrease in orthophosphate concentrations was observed. This pattern could be explained as a consequence of reduced quantities of phosphorus used in detergents, in the late 1980s. No significant change in any hydrochemical or biological property was observed.

  2. Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period

    PubMed Central

    Jarow, Jonathan P.; Lemery, Steven; Bugin, Kevin; Khozin, Sean; Moscicki, Richard

    2016-01-01

    Background The purpose of this study was to describe the experience of the Center of Drug Evaluation and Research (CDER) with expanded access of investigational drugs. Methods Multiple searches of CDER’s document tracking system were performed to identify the number, type, and indication for all expanded access requests over the 10-year time period of January 2005 through December 2014. An additional search was performed to identify all active commercial investigational drug development programs during that time period and whether or not the clinical program was placed on hold. The two searches were then cross-referenced to identify those commercial investigational drug development programs placed on clinical hold due to serious adverse events occurring within expanded access programs. Results CDER receives over 1000 applications for expanded access each year. The majority are for single patients, roughly evenly split between emergency and nonemergency use. The vast majority, 99.7%, are allowed to proceed. The incidence of clinical holds for all commercial investigational drug development programs is 7.9%, as compared to only 0.2% related to adverse events observed in patients receiving drug treatments under expanded access. Conclusions The expanded access program is viewed as a success from FDA’s perspective based on the large number of applications processed and allowed to proceed each year. However, the actual number of patients and their health care providers that desire drug treatments available under expanded access is not known. It is exceedingly rare for a serious adverse event under expanded access to affect the development program for that drug. PMID:27917324

  3. Molecular epidemiology of extended-spectrum-β-lactamase-producing Klebsiella pneumoniae over a 10 year period in Calgary, Canada.

    PubMed

    Peirano, Gisele; Sang, Jessica Hung King; Pitondo-Silva, André; Laupland, Kevin B; Pitout, Johann D D

    2012-05-01

    A study was designed to investigate the molecular epidemiology of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolated in a centralized region over a 10 year period (2000-09). Molecular characterization was done using isoelectric focusing, PCR and sequencing for bla(CTX-M), bla(TEM) and bla(SHV) genes and plasmid-mediated quinolone resistance determinants. Genetic relatedness was determined with PFGE using XbaI and multilocus sequencing typing. A total of 89 patients with incident infections were identified; the majority presented with hospital-onset urinary tract infections. The absolute number of ESBL-producing isolates remained very low until 2003, increased slightly in 2004, remained stable until 2008 and then in 2009 there was an abrupt increase in the numbers of ESBL producers identified. The majority of K. pneumoniae produced CTX-M-14 and -15, and have replaced SHV-12-producing isolates since 2005. We identified four different major sequence types (STs) among 32% of isolates (i.e. ST17, ST20, and the new ST573 and ST575) and provided insight into their clinical and molecular characteristics. The ST isolates were more likely to produce community-onset infections, were associated with bla(CTX-M) and emerged during the latter part of the study period. ST17 produced CTX-M-15 and SHV-12, and was more likely to be positive for qnrB; ST20 produced CTX-M-14 and was positive for qnrS. The multiresistant ST575 that produced CTX-M-15 appeared in 2009. Our study highlights the importance of molecular epidemiology in providing insight into the emergence, characteristics and distribution of STs among ESBL-producing K. pneumoniae.

  4. [Maternal mortality in the Hospital General de Matamoros Dr. Alfredo Pumarejo Lafaurie for a period of 10 years].

    PubMed

    González-Rosales, Ricardo; Ayala-Leal, Isabel; Cerda-López, Jorge Alejandro; Cerón-Saldaña, Miguel Angel

    2010-04-01

    In Mexico, maternal mortality has fallen substantially in recent decades. Although according to the Secretaria de Salud, in Tamaulipas the maternal mortality rate has increased in recent years. Despite these facts, Tamaulipas ranks among the ten institutions with the lowest level of maternal mortality. To describe the basic elements of epidemiologic behavior of maternal mortality during a period of ten years at the Gynecology and Obstetrics department of the Hospital General de Matamoros Dr. Alfredo Pumarejo Lafaurie in Tamaulipas, Mexico. A descriptive, transverse, retrospective and a cases series research was carried out at the Gynecology and Obstetrics department of the Hospital General de Matamoros Dr. Alfredo Pumarejo Lafaurie in Tamaulipas, Mexico. There was a revision of the expedients of direct and indirect obstetric maternal deaths occurred from January 1, 1998 to December 31, 2007. We used descriptive statistics with central trend measurements and standard deviation. 30 obstetric maternal deaths were registered. Maternal death ratio was 87.2 x 100,000 live births during the 10 years. The average age of patients was 25.1 +/- 7.8 years old. 54% were in their first pregnancy. Only 20% had adequate prenatal control. Direct obstetric causes were 60% and indirect obstetric causes 40%. The main causes of maternal deaths were preeclampsia/eclampsia (27%), obstetric hemorrhage (20%) and gravid-puerperal sepsis (13%). 83% was foreseeable. It was noted a clear trend towards the reduction in the maternal mortality ratio in the decade from 1998 to 2007. Preeclampsia-eclampsia and obstetric hemorrhage remain the main causes of maternal death. The maternal mortality ratio tended to invest when comparing the first five years with the last five years of the study, which talks about improvements in management and direct obstetric causes prevention.

  5. Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period.

    PubMed

    Noh, Ji Yun; Cheong, Hee Jin; Song, Joon Young; Kim, Woo Joo; Song, Ki-Joon; Klein, Terry A; Lee, Sam H; Yanagihara, Richard; Song, Jin-Won

    2013-09-01

    Laboratory diagnosis of hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by rodent-borne hantaviruses in Asia and Europe, depends primarily on serological methods. Since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of HFRS. To investigate the epidemioclinical features of HFRS patients treated at a tertiary-care teaching hospital in Seoul over a 10-year period. Medical records of HFRS patients, admitted to a tertiary-care teaching hospital during February 2002 to February 2012, were reviewed. Sera from patients were tested for Hantaan virus (HTNV) and Seoul virus (SEOV) RNA using RT-PCR. Among 35 HFRS patients (mean age was 44.2±14.7 years), 29 were male (82.9%). Acute renal failure developed in 27 patients (77.1%), and 12 patients (34.3%) were admitted to the intensive care unit (ICU). Conjunctival injection (OR 10.32, 95% CI 1.09-97.77, P=.04) and initial serum albumin less than 3g/dL (OR 22.83, 95% CI 1.45-359.93, P=.03) were risk factors for ICU admission. Of 35 acute-phase sera, 11 (31.4%) were positive for HTNV RNA. None were positive for SEOV RNA. HFRS was characterized by the clinical triad of fever, renal insufficiency and gastrointestinal symptoms. Conjunctival injection and serum albumin level were related to severity. A large-scale multi-center study is needed to enhance insights into epidemioclinical characteristics of HFRS in Korea. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review.

    PubMed

    Koscova, Silvia; Zakova Slivarichova, Dana; Tomeckova, Ivana; Melicherova, Katarina; Stelzer, Martin; Janakova, Alzbeta; Kosorinova, Dana; Belay, Girma; Mitrova, Eva

    2016-09-24

    Creutzfeldt-Jakob disease is a rare, but rapidly progressive, up to now untreatable and fatal neurodegenerative disorder. Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is difficult; however, it can be facilitated by suitable biomarkers. Aim of the present study is to compare levels of cerebrospinal fluid biomarkers (total tau protein, phosphorylated-tau protein, protein 14-3-3 and amyloid beta) in Slovak population of CJD suspect cases, retrospectively in over a 10-year period. One thousand three hundred sixty-four CSF samples from patients with suspect CJD, forming a homogenous group in terms of geographical as well as of equal transport conditions, storage and laboratory processing, were analysed. Definite diagnosis of Creutzfeldt-Jakob disease was confirmed in 101 patients with genetic form, and 60 patients with its sporadic form of the disease. Specificity of protein 14-3-3 and total tau in both forms CJD was similar (87 % for P14-3-3/85 % for total tau), sensitivity to P 14-3-3 and total tau was higher in sporadic Creutzfeldt-Jakob disease (sCJD) (90/95 %) than in genetic Creutzfeldt-Jakob disease (gCJD) (89/74 %). As expected, the total tau levels were significantly higher in CJD patients than in controls, but there was also significant difference between gCJD and sCJD (levels in gCJD were lower; p = 0.003). There was no significant difference in p-tau and Aβ 1-42 levels neither between both CJD forms nor between CJD patients and control group.

  7. Formulation of an organic carbon trajectory over a 10-year period on a restored spoil island in south-central Florida

    NASA Astrophysics Data System (ADS)

    Schafer, T.; Ellis, R.; Osborne, T.; Hicks Pries, C.

    2015-12-01

    Long-term monitoring of restoration projects aims to determine long-term sustainability and stability of restored systems. In coastal wetlands, one indicator of restoration of ecosystem function can be seen with organic matter (specifically carbon) accretion. SL-15, a spoil island in Fort Pierce, Fl was restored in 2005, and has been monitored for return to natural condition over the last 10 years.. To assess sediment carbon accretion, sediment cores were collected in a set of eight plots, located on the SL-15 mangrove island and the surrounding seagrass recruitment area. These were analyzed for organic carbon, microbial biomass carbon, extractable carbon, and total nitrogen. The biogeochemical data collected in the previous year was compared to data collected in 2005-2007. Vegetation surveys were also completed to show the build-up of organic material in accordance with vegetation shift over the 9-year period. From this information, a trajectory has been formulated on organic carbon accretion and vegetation shift from the time of orginal restoration activities. By comparison to control sites nearby, realistic estimates of time required to reach natural levels of carbon and vegetation community structure can be calculated..

  8. Causes of death in Japanese diabetics: A questionnaire survey of 18,385 diabetics over a 10-year period.

    PubMed

    Hotta, Nigishi; Nakamura, Jiro; Iwamoto, Yasuhiko; Ohno, Yoshiyuki; Kasuga, Masato; Kikkawa, Ryuichi; Toyota, Takayoshi

    2010-04-22

    We collated and analysed data from hospital records regarding the cause of death of 18,385 patients with diabetes who died in 282 medical institutions throughout Japan over the 10-year period between 1991 and 2000. Autopsy was carried out in 1750 cases. The most frequent cause of death in all 18,385 cases was malignant neoplasia, accounting for 34.1% of cases, followed by vascular diseases (including diabetic nephropathy, ischemic heart diseases and cerebrovascular diseases) in 26.8%, infections in 14.3%, and then diabetic coma in 1.2%. The most common malignancy was liver cancer, accounting for 8.6% of all the deaths. Of the deaths from vascular diseases, diabetic nephropathy was the cause of death in 6.8% of cases, and the frequency as cause of death for ischemic heart diseases and cerebrovascular diseases were similar at 10.2% and 9.8%, respectively. Myocardial infarction accounted for almost all the deaths from ischemic heart diseases, whereas deaths from cerebral infarction were 2.2-fold as common as those from cerebral hemorrhage. In the analyses of the relationship between age and causes of death in diabetic patients who underwent autopsy, the overall mortality rate as a result of vascular diseases increased with age, although the mortality rates from diabetic nephropathy and cerebrovascular diseases increased little from the fifth decade of life. The mortality rate from ischemic heart diseases increased with age, however, and was higher than the other forms of vascular diseases from the sixth decade of life, accounting for approximately 50% of vascular deaths in the eighth decade. Malignant neoplasia was the most frequent cause of death from the fifth decade of life, and was extremely common in the seventh decade, accounting for 46.3% of all the deaths. The mortality rate from infections varied little between age groups from the fifth decade of life. In the analyses of glycemic control and the age at the time of death, lifespans were 2.5 years shorter in

  9. A survey of Cryptosporidium oocysts in water supplies during a 10-year period (2000-2009) in Seoul.

    PubMed

    Lee, Mok Young; Cho, Eun Joo; Lee, Jin Hyo; Han, Sun Hee; Park, Yong Sang

    2010-09-01

    This study has been conducted to estimate the occurrence of Cryptosporidium oocysts in water supplies in the Metropolitan area of Seoul, South Korea, for 10 years from 2000 to 2009. Water samples were collected quarterly at 6 intakes in the Han River and its largest stream and 6 conventional Water Treatment Plants (WTPs) serving drinking water for 10 million people of Seoul. Cryptosporidium oocysts were found in 22.5% of intake water samples and arithmetic mean was 0.65 oocysts/10 L (range 0-22 oocysts/10 L). Although the annual mean of oocyst number was as low as 0.04-1.90 oocysts/10 L, 3 peaks in 2004 and 2007 were observed and the pollution level was a little higher in winter. The lowest density was observed at Paldang intake and the pollution level increased at Kuui and Jayang intakes. At the end of the largest stream, oocysts were found in 70% of collected samples (mean 5.71 oocysts/10 L) and it seemed that its joining the Han River resulted in the increase at Kuui intake and downstream. Oocyst removal by physical process exceeded 2.0-2.3 log and then all finished water samples collected at 6 WTPs were negative for Cryptosporidium in each 100 L sample for 10 years. These results suggested that domestic wastewater from the urban region could be a source of Cryptosporidium pollution and separating sewage systems adjacent to the intakes could be meaningful for some intakes having weakness related to parasitological water quality.

  10. Hospital expenditure as a major driver of nurse labour force participation: evidence from a 10-year period in Canada.

    PubMed

    Vujicic, Marko; Onate, Kanecy; Laporte, Audrey; Deber, Raisa

    2011-05-01

    This paper examines trends in the nursing labour market in Canada over a period of dramatic fluctuations in hospital expenditures. We add to previous analysis that covered the period 1991-1996 and use Census data from 2001 to examine the relationship between hospital expenditure and nurse labour force participation. We find that shifts in labour force participation over the period 1991-2001 had a significant impact on the nursing supply in Canada. Individuals who were trained in nursing but were working outside the profession in 1996 because of budgetary reductions and layoffs in hospitals had largely been reabsorbed back into nursing jobs by 2001. Our analysis provides further empirical evidence that the labour force participation among individuals trained in nursing is driven to a large extent by demand-side factors.

  11. Changes in metabolic parameters in patients with severe mental illness over a 10-year period: A retrospective cohort study.

    PubMed

    Heald, Adrian H; Martin, Julie L; Payton, Tony; Khalid, Luma; Anderson, Simon G; Narayanan, R Prakash; De Hert, Marc; Yung, Alison; Livingston, Mark

    2017-01-01

    Diabetes, obesity and metabolic syndrome are highly prevalent in patients with severe mental illness and can impose a major physical health burden. To determine how anthropometric and metabolic features changed over time in a retrospective cohort of people with Severe Mental Illness living in Cheshire, UK. In all, 1307 individuals on the severe mental illness Register were followed up between 2002 and 2012 in UK general practice. Subjects were identified through a pseudanonymised search of general practice registers. Baseline body mass index was 28.6 kg/m(2) increasing to 31.0 at 10-year follow-up ( r(2) = 0.84; p = 0.0002). There was a significant increase in fasting blood glucose from 5.72 to 6.79 mmol/L ( r(2) = 0.48; p = 0.026). Correspondingly, there was a strong positive univariate relation between increase in body mass index and fasting blood glucose ( r(2) = 0.54; p < 0.0001) taking into account all measurements. Fasting blood glucose also increased slightly with age ( p = 0.028). With increasing use of statins, total cholesterol fell from 4.5 to 3.9 mmol/L ( r(2) = 0.88; p = 0.0001), as did low-density lipoprotein cholesterol from 3.43 to 2.35 mmol/L ( r(2) = 0.94; p = 0.0001). In multivariate models, adjusting for age, gender, smoking and blood pressure, each unit increase in body mass index (odds ratio = 1.07 [1.01, 1.13]; p = 0.031) and triglycerides (odds ratio = 1.28 (1.06, 1.55); p = 0.009) was independently associated with an increased risk of having type 2 diabetes. Increasing body mass index relates to increasing rates of dysglycaemia over time. Measures to encourage weight reduction should be key strategies to reduce dysglycaemia rates in severe mental illness. Prescribing statins may have been effective in improving the lipid profile in this group.

  12. Assessing the changes of return periods of floods and droughts in response to climate change using a hydrologic modeling approach

    NASA Astrophysics Data System (ADS)

    Chien, H.

    2015-12-01

    When accessing the impacts of climate change on water resources, it is important to estimate changes in the frequencies and magnitudes of projected floods and droughts in response to climate change, considering that most disasters result from these hydrological extremes. The objective of this study is to estimate the changes of return periods of floods and droughts based on projected future streamflows in the Illinois River Watershed according to various climate change models. Future streamflows are simulated by combining data from 59 climate model scenarios with the Soil and Water Assessment Tool (SWAT) hydrologic model. Subsequently, a Gumbel distribution (Extreme Value Type I) is fitted to the annual maximum simulated streamflow to derive the number of return periods of future hydrological extremes. The annual minimum 7-day average streamflow has been adopted for drought analysis. A Weibull distribution (Extreme Value Type Ш) is used to analyze the return periods of low flows. The 10-year and 100-year return periods of floods and droughts from 2020 to 2049 and from 2070 to 2099 are analyzed in comparison to streamflows from 1975 to 2004. Results indicate that average streamflow predicted from 33 (2020-2049) and 29 (2070-2099) climate scenarios are expected to decrease. The majority of the 10-year and 100-year return periods of floods in 2020-2049 and 2070-2099 increase; however 10-year and 100-year return periods for droughts tend to decrease.

  13. Estimating return period of landslide triggering by Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Peres, D. J.; Cancelliere, A.

    2016-10-01

    Assessment of landslide hazard is a crucial step for landslide mitigation planning. Estimation of the return period of slope instability represents a quantitative method to map landslide triggering hazard on a catchment. The most common approach to estimate return periods consists in coupling a triggering threshold equation, derived from an hydrological and slope stability process-based model, with a rainfall intensity-duration-frequency (IDF) curve. Such a traditional approach generally neglects the effect of rainfall intensity variability within events, as well as the variability of initial conditions, which depend on antecedent rainfall. We propose a Monte Carlo approach for estimating the return period of shallow landslide triggering which enables to account for both variabilities. Synthetic hourly rainfall-landslide data generated by Monte Carlo simulations are analysed to compute return periods as the mean interarrival time of a factor of safety less than one. Applications are first conducted to map landslide triggering hazard in the Loco catchment, located in highly landslide-prone area of the Peloritani Mountains, Sicily, Italy. Then a set of additional simulations are performed in order to evaluate the traditional IDF-based method by comparison with the Monte Carlo one. Results show that return period is affected significantly by variability of both rainfall intensity within events and of initial conditions, and that the traditional IDF-based approach may lead to an overestimation of the return period of landslide triggering, or, in other words, a non-conservative assessment of landslide hazard.

  14. Long-term health-related quality of life after spontaneous nontraumatic subarachnoid hemorrhage: self and proxy reports in a 10-year period.

    PubMed

    Kapapa, Thomas; Woischneck, Dieter; Tjahjadi, Martin

    2014-01-01

    This study sought to examine health-related quality of life several years after spontaneous nontraumatic subarachnoid hemorrhage. Recent studies report impairments to be improved as far as normal levels. We question such an improvement in our own patient population over a period of 10 years. The Medical Outcomes Study 36-Item and Medical Outcomes Study 12-Item Short-Form Health Surveys on health-related quality of life were used to question 236 patients and 235 proxies. The patients were assigned to 5 groups according to the time that had elapsed since their hemorrhage: 1 year N = 22, 2 years N = 36, 5 years N = 86, 8 years N = 61, and 10 years N = 31. Analyses of variance (ANOVA, Kruskal-Wallis) and correlation (Spearman, Kendall tau) were used in an exploratory approach. Significance was established as P ≤ 0.05. Over a period of 10 years, health-related quality of life is found to be impaired, and is reported as such by the patients themselves and their proxies. Comparison of the mean values between the groups, ie, 1, 2, 5, and 10 years, revealed no significant differences in health-related quality of life. The calculations with a view to correlations between the group means and time since hemorrhage also produced only very weak correlations of no significance. Health-related quality of life is impaired over a period of 10 years. Spontaneous nontraumatic subarachnoid hemorrhage should be regarded as a chronic cerebrovascular condition. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Psychological distress as a determinant of changes in body mass index over a period of 10years.

    PubMed

    Cloostermans, Laura; Picavet, H Susan J; Bemelmans, Wanda J E; Verschuren, W M Monique; Proper, Karin I

    2015-08-01

    To examine the longitudinal relationship between psychological distress and body mass index (BMI) changes over a period of five and ten years. Data were used from the Dutch, prospective, population based Doetinchem Cohort study over the period 1995/1999 until 2005/2009 (N=5504). Psychological distress was assessed using the Mental Health Inventory (MHI-5). BMI (kg/m(2)) was calculated from measured body height and body weight. GEE analyses were used to examine the relationship between psychological distress at baseline and BMI change, and the development of overweight over five years. Linear and logistic regression analyses were used to examine these relations over ten years. Psychological distress predicted an extra overall increase in BMI of 0.14kg/m(2) (95% CI 0.03-0.25) over five years and an increase of 0.18kg/m(2) (95% CI 0.01-0.35) over ten years, when comparing psychologically distressed participants to psychologically healthy participants. This was especially the case among persons with normal weight (five years; B=0.26kg/m(2), 95% CI=0.12-0.40/ten years; B=0.32kg/m(2) 95% CI=0.11-0.53) and moderate overweight (five years: B=0.18kg/m(2), 95% CI=0.02-0.35) at baseline. Psychological distress did not predict the development of overweight five and ten years later. The results in this study indicated that psychological distress predicted an increased risk in gaining weight, but did not result in an increased risk for developing overweight. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. [Statistical evaluation of clinical characteristics and therapeutic management of Hodgkin disease in children over a 10 year period].

    PubMed

    Efrosă, Irina; Miron, Ingrid; Tansanu, I

    2010-01-01

    Hodgkin disease represents the third malign disease like frequency registered to children. Generally, the most cases have been observed to children between 10 and 15 years old. In our study the patients have been investigated on Pediatric Hemato-Oncologic Department from Clinical and Emergencies Hospital for Children "Sf. Maria" Iaşi in a period between 1995 and 2004. The age of patients was between 2 and 17 years, from this group 31 were boys (54.38%) and 21 girls (45.62%). The medium incidence of disease was 5.7 cases per year. Histological analysis indicates 2 cases with lymphocyte prevalence (3.50%), 18 with nodular sclerosis (31.58%), 32 with mixed cellularity (56.14%) and 5 patients with lymphoid depletion (8.78%). Ann-Arbor classification of disease indicates high frequency of stage II on the beginning (38 cases), with primary localization to neck (52 cases) and mediastinum (29 cases). 35 patients have presented biochemical syndrome (stage b). After therapeutically intervention on 55 patients the recovery has been observed, 42 patients didn't present relapse symptoms, 5 patients presented precocious relapse (under 12 months), respectively 6 patients presented tardy relapse (after 12 months). The factors for favorable prognosis were: histology with lymphocyte prevalence, stage I or II without systemic signs (FFS 96%), primary localization of disease on one or two groups of ganglions, without hilar and mediastinal zones.

  17. Deriving robust return periods for tropical cyclone inundations from sediments

    NASA Astrophysics Data System (ADS)

    Nott, Jonathan F.; Jagger, Thomas H.

    2013-01-01

    Return periods for tropical cyclone (TC) marine inundations are usually derived from synthetic data sets generated from deterministic models or by extrapolating short historical records. Such approaches contain considerable uncertainties because it is difficult to test their veracity until a sufficiently long period has elapsed. These approaches also often only consider storm surges or storm tides and not the total inundation, which includes waves, set-up and run-up, likely to flood a coastal property. An alternative approach is to examine sedimentary records of actual events that occurred throughout the late Holocene. Sedimentary beach ridges are unique amongst the different types of storm inundation sedimentary records because they record variations in the height of total marine inundations rather than a censoring level as occurs with overwash deposits. The limitation in using beach ridges to derive return periods for inundations has been the lack of a robust statistical model that accurately describes the distribution of these events over the past several millennia. Such a model is presented here using a Generalized Extreme Value distribution and Bayesian analysis of a sand beach ridge plain record of extreme TC-generated marine inundations from northeast Australia. Using this approach, the return period of the marine inundation generated by severe TC Yasi is determined. This return period differs considerably from estimates determined using a probability-based approach, which extrapolates from a short historical record. With global climate changing and the magnitude of marine inundations expected to increase, there is mounting pressure to develop national standards for marine flood loadings on coastal buildings. Deriving accurate return periods of these events will be critical to this endeavor, and this approach will be applicable at numerous localities globally where storm deposited beach ridges occur.

  18. 27 CFR 40.163 - Semimonthly tax return periods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Semimonthly tax return periods. 40.163 Section 40.163 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE..., 2011 through Feb. 24, 2014. ...

  19. Bone response to dental implants after a 3- to 10-year loading period: a histologic and histomorphometric report of four cases.

    PubMed

    Iezzi, Giovanna; Degidi, Marco; Shibli, Jamil A; Vantaggiato, Giovanni; Piattelli, Adriano; Perrotti, Vittoria

    2013-01-01

    The aim of this study was to histologically and histomorphometrically analyze the peri-implant tissue reactions and the bone-titanium interface in loaded Ankylos implants retrieved after loading periods of longer than 1 year. The archives of the Implant Retrieval Center of the Dental School of the University of Chieti- Pescara were searched for Ankylos implants retrieved from humans after a loading period of longer than 1 year. A total of four implants were found: one had been retrieved after 3 years (Friadent plus surface), two after 3.5 years (Friadent plus surface), and one after 10 years (Deep Profile surface). All implants had been loaded; two had been loaded immediately. One implant was retrieved after fracture, one was retrieved after fracture of the superstructure, and the other two were retrieved because of bone resorption with or without infection. Compact bone with few small marrow spaces was present around the three implants retrieved after 3 and 3.5 years; trabecular bone was present around the implant retrieved after 10 years. The bone-implant contact of the three best threads was 35% for the implant retrieved after 10 years, 99% for the implant retrieved after 3 years, and 100% for the implants retrieved after 3.5 years. No untoward effects were present at the interface, and a high bone-implant contact was present around the implants with the microstructured surface. The data show that these implants had the potential to maintain osseointegration under long-term function with continuous and ongoing bone remodeling.

  20. Return times at periodic points in random dynamics

    NASA Astrophysics Data System (ADS)

    Haydn, Nicolai; Todd, Mike

    2017-01-01

    We prove a quenched limiting law for random measures on subshifts at periodic points. We consider a family of measures {≤ft\\{{{μω}\\right\\}}ω \\in Ω } , where the ‘driving space’ Ω is equipped with a probability measure which is invariant under a transformation θ. We assume that the fibred measures {μω} satisfy a generalised invariance property and are ψ-mixing. We then show that for almost every ω the return times to cylinders A n at periodic points are in the limit compound Poisson distributed for a parameter ϑ which is given by the escape rate at the periodic point.

  1. Decline in lymphatic filariasis transmission with annual mass drug administration using DEC with and without albendazole over a 10year period in India.

    PubMed

    Sunish, I P; Kalimuthu, M; Rajendran, R; Munirathinam, A; Ashok Kumar, V; Nagaraj, J; Tyagi, B K

    2015-02-01

    The National Programme for the Elimination of Lymphatic Filariasis is underway in the endemic districts of Tamil Nadu State, South India, since 2001. Annual mass drug administration (MDA) was carried out by the state health department to all eligible individuals. The impact of MDAs on transmission parameters was evaluated in 2 revenue blocks, viz, one with DEC alone and the other with a combination of albendazole. After 10 years with 6 annual MDAs, the transmission indices reached low levels in both treatment arms, but still persisted. However, the DEC alone arm showed higher transmission rates, compared to the DEC+ALB arm. Few villages which demonstrated persistent transmission need to be targeted with an additional control measure viz, vector control, to achieve LF elimination. It is evident from the 10 year period of the study that inclusion of albendazole along with DEC has significantly reduced the transmission indices to almost nil level, as compared to DEC alone. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Return periods of global climate fluctuations and the pause

    NASA Astrophysics Data System (ADS)

    Lovejoy, S.

    2014-07-01

    An approach complementary to General Circulation Models (GCMs), using the anthropogenic CO2 radiative forcing as a linear surrogate for all anthropogenic forcings [Lovejoy], was recently developed for quantifying human impacts. Using preindustrial multiproxy series and scaling arguments, the probabilities of natural fluctuations at time lags up to 125 years were determined. The hypothesis that the industrial epoch warming was a giant natural fluctuation was rejected with 99.9% confidence. In this paper, this method is extended to the determination of event return times. Over the period 1880-2013, the largest 32 year event is expected to be 0.47 K, effectively explaining the postwar cooling (amplitude 0.42-0.47 K). Similarly, the "pause" since 1998 (0.28-0.37 K) has a return period of 20-50 years (not so unusual). It is nearly cancelled by the pre-pause warming event (1992-1998, return period 30-40 years); the pause is no more than natural variability.

  3. The 2011 Thailand flood: climate causes and return periods

    NASA Astrophysics Data System (ADS)

    Gale, Emma; Saunders, Mark

    2013-04-01

    Thailand is one of the most developed and wealthiest countries in Southeast Asia. However, its tropical location and the influence of seasonal monsoon rains and local topography make it prone to floods. The Thailand floods in 2011 were especially severe causing estimated losses of US 30 billion (economic) and US 12 billion (insured) (Swiss Re, 2012). This insured loss ranks easily as the highest ever worldwide from a freshwater flood disaster (Swiss Re, 2012). We review the nature, impacts and historical ranking of the 2011 Thailand flood, and then discuss the climate causes for the exceptional rainfall which triggered the flood - annual rainfall in 2011 was the highest in Thailand's 61-year precipitation record (Thai Meteorological Department, 2011). Thai precipitation data from 100 stations for the period 1992-2011, NCEP/NCAR mean sea level pressure (MSLP) data and best-track data from the Joint Typhoon Warning Center for the period 1992-2011 are used in this study. We find that the floods were caused by a combination of a strong Southeast Asian summer monsoon that brought high rainfall across the country between May and October, and by the remnants of four tropical storms that brought high rainfall to northern Thailand between June and October. During the monsoon season the Southern Oscillation was moderately positive and, as a result, likely contributed to the high monsoonal rains. We estimate the return periods for the 2011 Thai rains and compare these to satellite-derived return periods for 2011 Thai river flow. The rainfall return period varies from 8-20 years in the north and south of the country to 1-8 years in the east and centre of Thailand. Satellite-derived river flows at two locations on the Chao Phraya River suggest a return period of 10-20 years. The return period is also estimated using historical flood records (Brakenridge, 2012) which suggest a return period of 5-6 years. A 'consensus' return period for the 2011 Thai flood is estimated to be 10

  4. Determining the Return Period of Storm Surge Events in the Philippines

    NASA Astrophysics Data System (ADS)

    Santiago, Joy; Suarez, John Kenneth; Lapidez, John Phillip; Mendoza, Jerico; Caro, Carl Vincent; Tablazon, Judd; Ladiero, Christine; Mahar Francisco Lagmay, Alfredo

    2015-04-01

    The devastating damages generated by the Tropical Cyclone Haiyan storm surges in Eastern Samar, Philippines prompted the Department of Science and Technology-Project NOAH (Nationwide Operational Assessment of Hazards) to calculate the return period and storm surge exceedance probability of these events. The recurrence interval or the period of return of a storm surge event is the estimated likelihood that that event would occur again. Return periods are measured through historical data denoting the interval of recurrence in average over a period of time. The exceedance probability however, is a graphical representation that describes the probability that some various levels of loss will be exceeded over a future time period or will be surpassed over a given time. DOST-Project NOAH simulates storm surge height time series using JMA storm surge model which is a numerical model based on shallow water equations. To determine the period of recurrence of storm surges with this type of intensity, the agency intends to compute the estimation of storm surge heights generated by tropical cyclones for 2-year, 5-year, 10-year, 25-year, 50-year and 100-year return periods for the Philippine coast. The storm surge time series generated from JMA combined with WXTide simulation, a software containing archives/catalogues of world-wide astronomical tides, and 5-meter resolution DEM were used as input parameters for the inundation model, which shows probable extent of flooding at a specific storm surge return period. Flo-2D two-dimensional flood routing model, a GIS integrated software tool that facilitates the creation of the flood model grid system, was used for flood hazard model. It is a simple volume conservation model composed of processor program that facilitate graphical editing and mapping of flooding details which uses continuity equation and the dynamic wave momentum equations. The measurements of storm surge return period and probable extent of coastal flooding in the

  5. Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh.

    PubMed

    Seed, Kimberley D; Bodi, Kip L; Kropinski, Andrew M; Ackermann, Hans-Wolfgang; Calderwood, Stephen B; Qadri, Firdausi; Camilli, Andrew

    2011-01-01

    Lytic bacteriophages are hypothesized to contribute to the seasonality and duration of cholera epidemics in Bangladesh. However, the bacteriophages contributing to this phenomenon have yet to be characterized at a molecular genetic level. In this study, we isolated and sequenced the genomes of 15 bacteriophages from stool samples from cholera patients spanning a 10-year surveillance period in Dhaka, Bangladesh. Our results indicate that a single novel bacteriophage type, designated ICP1 (for the International Centre for Diarrhoeal Disease Research, Bangladesh cholera phage 1) is present in all stool samples from cholera patients, while two other bacteriophage types, one novel (ICP2) and one T7-like (ICP3), are transient. ICP1 is a member of the Myoviridae family and has a 126-kilobase genome comprising 230 open reading frames. Comparative sequence analysis of ICP1 and related isolates from this time period indicates a high level of genetic conservation. The ubiquitous presence of ICP1 in cholera patients and the finding that the O1 antigen of lipopolysaccharide (LPS) serves as the ICP1 receptor suggest that ICP1 is extremely well adapted to predation of human-pathogenic V. cholerae O1.

  6. Occult hernias and bilateral endoscopic total extraperitoneal inguinal hernia repair: is there a need for prophylactic repair? : Results of endoscopic extraperitoneal repair over a period of 10 years.

    PubMed

    Saggar, V R; Sarangi, R

    2007-02-01

    An advantage of the endoscopic total extraperitoneal approach over the conventional hernia repair is detection of an unsuspected, asymptomatic hernia on the contralateral side. A high incidence of occult contralateral hernias has been reported in the literature. However, few studies have examined the incidence of development of a hernia on the healthy side evaluated previously during an endoscopic unilateral hernia repair. This study aims to evaluate the incidence of development of a contralateral hernia after a previous bilateral exploration. The need for a prophylactic contralateral repair is also addressed. We retrospectively reviewed the results of 822 endoscopic total extraperitoneal inguinal hernia repairs done in 634 patients over a period of 10 years from May 1993 to 2003. Incidence of hernia undetected clinically and during previous contralateral repair was assessed over a follow up period ranging from 10 to 82 months. About 7.97% of bilateral hernias were clinically occult hernias. Only 1.12% of unilateral hernia repairs (who had undergone a contralateral evaluation at surgery) subsequently developed a hernia on the other side. The endoscopic approach to inguinal hernia repair is an excellent tool to detect and treat occult contralateral hernias. The incidence of hernia occurring at the contralateral side after a previous bilateral exploration is low, hence a prophylactic repair on the contralateral side is not recommended on a routine basis.

  7. Increasing Recovery of Nontuberculous Mycobacteria from Respiratory Specimens over a 10-Year Period in a Tertiary Referral Hospital in South Korea

    PubMed Central

    Chang, Boksoon; Jeong, Byeong-Ho; Jeon, Kyeongman; Kim, Su-Young; Lee, Nam Yong; Ki, Chang-Seok; Kwon, O Jung

    2013-01-01

    Background The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Methods We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. Results During the study period, 32,841 respiratory specimens from 10,563 patients were found to be culture-positive for mycobacteria. These included 12,619 (38%) Mycobacterium tuberculosis and 20,222 (62%) NTM isolates. The proportion of NTM among all positive mycobacterial cultures increased from 43% (548/1,283) in 2001 to 70% (3,341/4,800) in 2011 (p<0.001, test for trend). The recovery rate of NTM isolates from acid-fast bacilli smear-positive specimens increased from 9% (38/417) in 2001 to 64% (1,284/1,997) in 2011 (p<0.001, test for trend). The proportion of positive liquid cultures was higher for NTM than for M. tuberculosis (p<0.001). The most frequently isolated NTM were Mycobacterium avium-intracellulare complex (53%) and Mycobacterium abscessus-massiliense complex (25%). Conclusion The recovery rate of NTM from respiratory specimens in South Korea has increased steadily. PMID:24348667

  8. Peri-implant bone response around a human hydroxyapatite-coated implant retrieved after a 10-year loading period: a case report.

    PubMed

    Iezzi, Giovanna; Malchiodi, Luciano; Quaranta, Alessandro; Ghensi, Paolo; Piattelli, Adriano

    2013-01-01

    This case report presents a histologic and histomorphometric evaluation of the peri-implant tissues of a HA-coated implant retrieved due to peri-implantitis after a 10-year loading period. The implant was retrieved with a trephine and treated to obtain thin ground sections. At low-power magnification mostly compact, mature bone with small marrow spaces could be observed at the interface with the implant. The coating was always present in the areas where bone was detected, the bone was always in close contact with the coating, and there was no detachment between the metal and coating or between the coating and bone. Areas of bone remodeling were demonstrated by the presence of many secondary osteons and reversal lines close to the implant surface. The bone-implant contact percentage was 36.3% ± 1.2%. The percentage of the implant surface covered by the HA coating without bone, where bone may have detached during retrieval, was 32.6% ± 2.8%. This HA-coated implant, continued to demonstrate more than adequate BIC after many years of function and the potential to maintain osseointegration in the long term.

  9. Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005–2014)

    PubMed Central

    Filipello, Virginia; Amato, Ettore; Gori, Maria; Huedo, Pol; Ciceri, Giulia; Lomonaco, Sara

    2017-01-01

    In developed countries, pregnancy-related listeriosis accounts for 20–43% of total invasive listeriosis. This work describes the first pregnancy-related listeriosis survey in Italy based on two data sources, that is, mandatory notification system and regional laboratory-based network. Out of 610 listeriosis cases reported over a 10-year period, 40 were pregnancy-related (6.6%). Among these, 29 pregnancy-related isolates were available and have been analysed with serotyping, Pulsed-Field Gel Electrophoresis, and Multi-Virulence-Locus Sequence Typing. No maternal fatality was recorded, but 11 (29.7%) pregnancies resulted in a foetal death, a miscarriage, or a birth of a foetus dying immediately after birth. The average incidence of pregnancy-related listeriosis was 4.3 cases per 100000 births, and the proportion of pregnancy-associated listeriosis among ethnic minorities was significantly higher compared to the general population (30.0% versus 3.5%, P < 0.01). L. monocytogenes isolates belonged to serotypes 1/2a, 1/2b, and 4b, with the latter significantly more prevalent among pregnancy-related isolates. Twenty different pulsotypes were distinguished and 16 out of the 29 isolates were classified into seven clusters. A total of 16 virulence types (VTs) were identified. Five VTs accounted for 45% of the total cases and coincided with those of previously described Epidemic Clones (ECs) of L. monocytogenes. PMID:28408795

  10. What Are the Trends in Tonsillectomy Techniques in Wales? A Prospective Observational Study of 19,195 Tonsillectomies over a 10-Year Period

    PubMed Central

    Walijee, Hussein; Al-Hussaini, Ali; Harris, Andrew; Owens, David

    2015-01-01

    There are a multitude of techniques to undertake tonsillectomy, with hot techniques such as diathermy and coblation being associated with a higher risk of secondary haemorrhage. The UK National Prospective Tonsillectomy Audit (2004) advocated cold steel dissection and ties to be the gold standard. This prospective observational study investigates the trends in tonsillectomy techniques across Wales in the last decade to establish if surgeons have adhered to this national guidance. Data relating to tonsillectomy were extracted over a 10-year period from 1 January 2003 to 31 December 2012 from the Wales Surgical Instrument Surveillance Programme database. A total of 19,195 patients were included. Time-series analysis using linear regression showed there was an increase in the number of bipolar diathermy tonsillectomies by 84% (Pearson's r = 0.762, p = 0.010) and coblation tonsillectomies by 120% (r = 0.825, p = 0.003). In contrast, there was a fall in the number of cold steel dissection tonsillectomies with ties by 60% (r = −0.939, p < 0.001). This observational study suggests that the use of bipolar and coblation techniques for tonsillectomy has increased. This deviation from national guidance may be due to these techniques being faster with less intraoperative bleeding. Further study for the underlying reasons for the increase in these techniques is warranted. PMID:26693228

  11. Incidence of peri-implant mucositis and peri-implantitis in edentulous patients with an implant-retained mandibular overdenture during a 10-year follow-up period.

    PubMed

    Meijer, Henny J A; Raghoebar, Gerry M; de Waal, Yvonne C M; Vissink, Arjan

    2014-12-01

    The aim of this sub-analysis of two prospective studies was to assess the incidence of peri-implant mucositis and peri-implantitis in fully edentulous patients with an implant-retained mandibular overdenture during a 10-year follow-up period. One hundred and fifty edentulous patients with two endosseous implants to support a mandibular overdenture were available from two prospective studies. Clinical and radiographic parameters were assessed at 5 and 10 years of functional loading. Incidence of peri-implant mucositis and peri-implantitis were calculated at implant level and patient level following the Consensus of the Seventh European Workshop on Periodontology on peri-implant diseases. Incidence of peri-implant mucositis at patient level was 51.9% after 5 years of evaluation and 57.0% after 10 years. Incidence of peri-implantitis at patient level was 16.9% after 5 years of evaluation and 29.7% after 10 years. Peri-implant mucositis and peri-implantitis do occur in totally edentulous patients and incidence numbers are high. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  12. Percutaneous CT fluoroscopy-guided core biopsy of pancreatic lesions: technical and clinical outcome of 104 procedures during a 10-year period.

    PubMed

    Strobl, Frederik Franz; Schwarz, Jens Benjamin; Haeussler, Sophia Marie; Paprottka, Philipp Marius; Rist, Carsten; Thierfelder, Kolja Martin; Boeck, Stefan; Heinemann, Volker; Reiser, Maximilian Ferdinand; Trumm, Christoph Gregor

    2017-08-01

    Background In unclear pancreatic lesions, a tissue sample can confirm or exclude the suspected diagnosis and help to provide an optimal treatment strategy to each patient. To date only one small study reported on the outcome of computed tomography (CT) fluoroscopy-guided biopsies of the pancreas. Purpose To evaluate technical success and diagnostic rate of all CT fluoroscopy-guided core biopsies of the pancreas performed in a single university center during a 10-year period. Material and Methods In this retrospective study we included all patients who underwent a CT fluoroscopy-guided biopsy of a pancreatic mass at our comprehensive cancer center between 2005 and 2014. All interventions were performed under local anesthesia on a 16-row or 128-row CT scanner. Technical success and diagnostic rates as well as complications and effective patient radiation dose were analyzed. Results One hundred and one patients (54 women; mean age, 63.9 ± 12.6 years) underwent a total of 104 CT fluoroscopy-guided biopsies of the pancreas. Ninety-eight of 104 interventions (94.2%) could be performed with technical success and at least one tissue sample could be obtained. In 88 of these 98 samples, a definitive pathological diagnosis, consistent with clinical success could be achieved (89.8%). Overall 19 minor and three major complications occurred during the intra- or 30-day post-interventional period and all other interventions could be performed without complications; there was no death attributable to the intervention. Conclusion CT fluoroscopy-guided biopsy of pancreatic lesions is an effective procedure characterized by a low major complication and a high diagnostic rate.

  13. Retrospective Analysis of Corticosteroid Treatment in Stevens-Johnson Syndrome and/or Toxic Epidermal Necrolysis over a Period of 10 Years in Vajira Hospital, Navamindradhiraj University, Bangkok.

    PubMed

    Roongpisuthipong, Wanjarus; Prompongsa, Sirikarn; Klangjareonchai, Theerawut

    2014-01-01

    Background. Stevens-Johnson syndrome (SJS) and/or toxic epidermal necrolysis (TEN) are uncommon and life-threatening drug reaction associated with a high morbidity and mortality. Objective. We studied SJS and/or TEN by conducting a retrospective analysis of 87 patients treated during a 10-year period. Methods. We conducted a retrospective review of the records of all patients with a diagnosis of SJS and/or TEN based on clinical features and histological confirmation of SJS and/or TEN was not available at the Department of Medicine, Vajira hospital, Bangkok, Thailand. The data were collected from two groups from 2003 to 2007 and 2008 to 2012. Results. A total of 87 cases of SJS and/or TEN were found, comprising 44 males and 43 females whose mean age was 46.5 years. The average length of stay was 17 days. Antibiotics, anticonvulsants, and allopurinol were the major culprit drugs in both groups. The mean SCORTEN on admission was 2.1 in first the group while 1.7 in second the group. From 2008 to 2012, thirty-nine patients (76.5%) were treated with corticosteroids while only eight patients (22.2%) were treated between 2003 and 2007. The mortality rate declined from 25% from the first group to 13.7% in the second group. Complications between first and second groups had no significant differences. Conclusions. Short-term corticosteroids may contribute to a reduced mortality rate in SJS and/or TEN without increasing secondary infection. Further well-designed studies are required to compare the effect of corticosteroids treatment for SJS and/or TEN.

  14. [Spectrum of microbial colonisation and resistance of a surgical ICU in a systematic comparison of the 10-year time period 1996-2005 using routine microbiological testing].

    PubMed

    Arndt, S; Lauf, H; Weiss, G; Lodes, U; Mroczkowski, P; Schulz, H-U; Lippert, H; König, W; Meyer, F

    2011-04-01

    urinary and wound infections as well as pneumonias through the observation period. Despite the decreasing incidence of Enterococcus and the consistent proportion of MRSA, the increase of resistant Enterococcus strains (0 % vs. 43.2 %; P < 0.05) is critical. However, in the Gram-negative microbial spectrum there was an increase of the bacteraemia rate but a fall of the detection rate in wound and endotracheal swabs. In parallel, an increase of the detection rate of E. coli in blood (6.5 % vs. 45.5 %; P < 0.05) and endotracheal swabs (9.2 % vs. 16.2 %; P < 0.05) is associated with an increase of multiresistant Enterobacteriaceae strains (0 % vs. 30.7 %; P < 0.05). The portion of multiresistant strains of Pseudomonas with 31 % stayed the same through the 10-year time period. While Candida-based colonisation showed a decreased incidence (25 % vs. 15 %; P < 0.05) during the whole investigation period, there was a relative rise in the frequency of candidemia. ICU relocation from the pavillon-based system to a new complex clinic building was not associated with any significant alteration of the microbial spectrum on the surgical ICU. Increasing incidences of resistant Enterococcus and Gram-negative problematic microbes may indicate a general spread of multi-resistant microbes under the steady selecting pressure of a not always adequately initiated antibiotic / antimicrobial therapeutic regimen and underline the required but specific and selected microbiological screening. © Georg Thieme Verlag KG Stuttgart ˙ New York.

  15. The Vaginal Microbiota over an 8- to 10-Year Period in a Cohort of HIV-Infected and HIV-Uninfected Women

    PubMed Central

    Mehta, Supriya D.; Donovan, Brock; Weber, Kathleen M.; Cohen, Mardge; Ravel, Jacques; Gajer, Pawel; Gilbert, Douglas; Burgad, Derick; Spear, Greg T.

    2015-01-01

    Background We identified predominant vaginal microbiota communities, changes over time, and how this varied by HIV status and other factors in a cohort of 64 women. Methods Bacterial DNA was extracted from reposited cervicovaginal lavage samples collected annually over an 8–10 year period from Chicago Women’s Interagency HIV Study participants: 22 HIV-negative, 22 HIV-positive with stable infection, 20 HIV-positive with progressive infection. The vaginal microbiota was defined by pyrosequencing of the V1/V2 region of the 16S rRNA gene. Scheduled visits included Bacterial vaginsosis (BV) screening; clinically detected cases were referred for treatment. Hierarchical clustering identified bacterial community state types (CST). Multinomial mixed effects modeling determined trends over time in CST, by HIV status and other factors. Results The median follow-up time was 8.1 years (range 5.5–15.3). Six CSTs were identified. The mean relative abundance (RA) of Lactobacillus spp. by CST (with median number of bacterial taxa) was: CST-1–25.7% (10), CST-2–27.1% (11), CST-3–34.6% (9), CST-4–46.8% (9), CST-5–57.9% (4), CST-6–69.4% (2). The two CSTs representing the highest RA of Lactobacillus and lowest diversity increased with each additional year of follow-up (CST-5, adjusted odds ratio (aOR) = 1.62 [95% CI: 1.34–1.94]; CST-6, aOR = 1.57 [95 CI: 1.31–1.89]), while the two CSTs representing lowest RA of Lactobacillus and higher diversity decreased with each additional year (CST-1, aOR = 0.89 [95% CI: 0.80–1.00]; CST-2, aOR = 0.86 [95% CI: 0.75–0.99]). There was no association between HIV status and CST at baseline or over time. CSTs representing lower RA of Lactobacillus were associated with current cigarette smoking. Conclusions The vaginal microbial community significantly improved over time in this cohort of women with HIV and at high risk for HIV who had regular detection and treatment referral for BV. PMID:25675346

  16. The vaginal microbiota over an 8- to 10-year period in a cohort of HIV-infected and HIV-uninfected women.

    PubMed

    Mehta, Supriya D; Donovan, Brock; Weber, Kathleen M; Cohen, Mardge; Ravel, Jacques; Gajer, Pawel; Gilbert, Douglas; Burgad, Derick; Spear, Greg T

    2015-01-01

    We identified predominant vaginal microbiota communities, changes over time, and how this varied by HIV status and other factors in a cohort of 64 women. Bacterial DNA was extracted from reposited cervicovaginal lavage samples collected annually over an 8-10 year period from Chicago Women's Interagency HIV Study participants: 22 HIV-negative, 22 HIV-positive with stable infection, 20 HIV-positive with progressive infection. The vaginal microbiota was defined by pyrosequencing of the V1/V2 region of the 16S rRNA gene. Scheduled visits included Bacterial vaginsosis (BV) screening; clinically detected cases were referred for treatment. Hierarchical clustering identified bacterial community state types (CST). Multinomial mixed effects modeling determined trends over time in CST, by HIV status and other factors. The median follow-up time was 8.1 years (range 5.5-15.3). Six CSTs were identified. The mean relative abundance (RA) of Lactobacillus spp. by CST (with median number of bacterial taxa) was: CST-1-25.7% (10), CST-2-27.1% (11), CST-3-34.6% (9), CST-4-46.8% (9), CST-5-57.9% (4), CST-6-69.4% (2). The two CSTs representing the highest RA of Lactobacillus and lowest diversity increased with each additional year of follow-up (CST-5, adjusted odds ratio (aOR) = 1.62 [95% CI: 1.34-1.94]; CST-6, aOR = 1.57 [95 CI: 1.31-1.89]), while the two CSTs representing lowest RA of Lactobacillus and higher diversity decreased with each additional year (CST-1, aOR = 0.89 [95% CI: 0.80-1.00]; CST-2, aOR = 0.86 [95% CI: 0.75-0.99]). There was no association between HIV status and CST at baseline or over time. CSTs representing lower RA of Lactobacillus were associated with current cigarette smoking. The vaginal microbial community significantly improved over time in this cohort of women with HIV and at high risk for HIV who had regular detection and treatment referral for BV.

  17. A Survey of the Collaboration Rate of Authors in the E-Learning Subject Area over a 10-Year Period (2005-2014) Using Web of Science

    ERIC Educational Resources Information Center

    Mohammadi, Aeen; Asadzandi, Shadi; Malgard, Shiva

    2017-01-01

    Partnership is one of the mechanisms of scientific development, and scientific collaboration or co-authorship is considered a key element in the progress of science. This study is a survey with a scientometric approach focusing on the field of e-learning products over 10 years. In an Advanced Search of the Web of Science, the following search…

  18. Treatment failure and drug resistance is more frequent in HIV-1 subtype D versus subtype A-infected Ugandans over a 10-year study period

    PubMed Central

    Kyeyune, Fred; Nankya, Immaculate; Metha, Samar; Akao, Juliet; Ndashimye, Emmanuel; Tebit, Denis M.; Rodriguez, Benigno; Kityo, Cissy; Salata, Robert A.; Mugyenyi, Peter; Arts, Eric J.

    2014-01-01

    Objectives To determine the impact of HIV-1 subtype on treatment outcomes and the emergence of drug resistance in the resource limited setting of Kampala, Uganda. Design The Joint Clinical Research Centre (JCRC) in Kampala, Uganda has provided over 2000 drug-resistant genotypes (DRGs) over the past 10 years as standard of care for patients failing therapy and 1403 from treatment-naive and experienced patients over the past 10 years have been analyzed for this study. Method Viral loads, CD4 cell count, treatment histories and other relevant clinical data was compared with the infecting HIV-1 subtype and DRGs of Ugandan patients failing treatment. Results Patients failing HAART with DRGs (n = 937) were more frequently infected with subtype D than expected on the basis of the subtype distribution in the treatment-naive population (n = 655) in Kampala (P < 0.001). Higher proportions of treatment failures among subtype D-infected patients were driven by resistance to nucleoside reverse transcriptase inhibitors (NRTI) (P < 0.0002) more than to non-NRTIs (P > 0.04) or protease inhibitors. Conclusion Higher rates of treatment failure among subtype D as compared with subtype A-infected Ugandans was analogous to the faster disease progression in subtype D-infected patients. The mechanism(s) by which drug resistance may emerge faster in subtype D HIV-1 may relate to higher replicative fitness and increased propensity for a CXCR4 tropism. PMID:23727942

  19. Forecasting the Burden of Advanced Knee Osteoarthritis over a 10-Year Period in a Cohort of 60–64 year-old US Adults

    PubMed Central

    Holt, Holly L.; Katz, Jeffrey N.; Reichmann, William M.; Gerlovin, Hanna; Wright, Elizabeth A.; Hunter, David J.; Jordan, Joanne M.; Kessler, Courtenay L.; Losina, Elena

    2010-01-01

    Objective To forecast the burden of symptomatic knee osteoarthritis (OA) in the elderly US population over a 10-year horizon. Design Using a computer simulation model of the natural history and management of knee OA combined with population-based data from the 2008 US Census we projected the 10-year burden of knee OA among persons 60–64 years of age. Knee OA incidence and progression rates were derived from national cohorts and calibrated to published literature. Results Using national data we estimated that 13% of 14,338,292 adults 60–64 years old have prevalent symptomatic, radiographic knee OA. Among persons surviving the next decade, 20% will have symptomatic advanced (Kellgren-Lawrence [K-L] grade 3) or end-stage (K-L 4) knee OA. Prevalence of advanced knee OA will range from 10% among non-obese to 35% among obese persons. Our estimates show that a more sensitive imaging tool, such as magnetic resonance imaging (MRI), may increase the number OA cases diagnosed by up to 94% assuming that 50% of all ‘pre-radiographic knee OA’ (K-L 1) has some evidence of cartilage degeneration seen on MRI. Conclusions Projecting new and advanced cases of knee OA among persons aged 60–64 years over the next decade creates a benchmark that can be used to evaluate population-based benefits of future disease-modifying OA drugs that are currently undergoing testing at various stages. PMID:20955807

  20. Forecasting the burden of advanced knee osteoarthritis over a 10-year period in a cohort of 60-64 year-old US adults.

    PubMed

    Holt, H L; Katz, J N; Reichmann, W M; Gerlovin, H; Wright, E A; Hunter, D J; Jordan, J M; Kessler, C L; Losina, E

    2011-01-01

    To forecast the burden of symptomatic knee osteoarthritis (OA) in the elderly US population over a 10-year horizon. Using a computer simulation model of the natural history and management of knee OA combined with population-based data from the 2008 US Census we projected the 10-year burden of knee OA among persons 60-64 years of age. Knee OA incidence and progression rates were derived from national cohorts and calibrated to published literature. Using national data we estimated that 13% of 14,338,292 adults 60-64 years old have prevalent symptomatic, radiographic knee OA. Among persons surviving the next decade, 20% will have symptomatic advanced (Kellgren-Lawrence [K-L] grade 3) or end-stage (K-L 4) knee OA. Prevalence of advanced knee OA will range from 10% among non-obese to 35% among obese persons. Our estimates show that a more sensitive imaging tool, such as magnetic resonance imaging (MRI), may increase the number of OA cases diagnosed by up to 94% assuming that 50% of all 'pre-radiographic knee OA' (K-L 1) has some evidence of cartilage degeneration seen on MRI. Projecting new and advanced cases of knee OA among persons aged 60-64 years over the next decade creates a benchmark that can be used to evaluate population-based benefits of future disease-modifying OA drugs that are currently undergoing testing at various stages. Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  1. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review.

    PubMed

    Moraschini, V; Poubel, L A da C; Ferreira, V F; Barboza, E dos S P

    2015-03-01

    The aim of this systematic review was to evaluate the survival and success rates of osseointegrated implants determined in longitudinal studies that conducted a follow-up of at least 10 years. A broad electronic search was conducted in MEDLINE/PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) for relevant publications in indexed journals, evaluating the clinical performance of dental implants. Using inclusion and exclusion criteria, two reviewers analyzed titles, abstracts, and complete articles, prioritizing studies of the randomized clinical trial type. A total of 23 articles were included in this review. Ten prospective studies, nine retrospective studies, and four randomized clinical trials, which evaluated 7711 implants, were selected. The mean follow-up time of the studies included was 13.4 years. All of the studies reported survival rates and mean marginal bone resorption values, with cumulative mean values of 94.6% and 1.3mm, respectively. Fourteen studies related success rates. Taking into consideration the disparate outcome measures employed to assess dental implant performance and within the limitations of this systematic review, we may affirm that osseointegrated implants are safe and present high survival rates and minimal marginal bone resorption in the long term. Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  2. The joint return period analysis of natural disasters based on monitoring and statistical modeling of multidimensional hazard factors.

    PubMed

    Liu, Xueqin; Li, Ning; Yuan, Shuai; Xu, Ning; Shi, Wenqin; Chen, Weibin

    2015-12-15

    As a random event, a natural disaster has the complex occurrence mechanism. The comprehensive analysis of multiple hazard factors is important in disaster risk assessment. In order to improve the accuracy of risk analysis and forecasting, the formation mechanism of a disaster should be considered in the analysis and calculation of multi-factors. Based on the consideration of the importance and deficiencies of multivariate analysis of dust storm disasters, 91 severe dust storm disasters in Inner Mongolia from 1990 to 2013 were selected as study cases in the paper. Main hazard factors from 500-hPa atmospheric circulation system, near-surface meteorological system, and underlying surface conditions were selected to simulate and calculate the multidimensional joint return periods. After comparing the simulation results with actual dust storm events in 54years, we found that the two-dimensional Frank Copula function showed the better fitting results at the lower tail of hazard factors and that three-dimensional Frank Copula function displayed the better fitting results at the middle and upper tails of hazard factors. However, for dust storm disasters with the short return period, three-dimensional joint return period simulation shows no obvious advantage. If the return period is longer than 10years, it shows significant advantages in extreme value fitting. Therefore, we suggest the multivariate analysis method may be adopted in forecasting and risk analysis of serious disasters with the longer return period, such as earthquake and tsunami. Furthermore, the exploration of this method laid the foundation for the prediction and warning of other nature disasters.

  3. Return periods of losses associated with European windstorm series in a changing climate

    NASA Astrophysics Data System (ADS)

    Karremann, Melanie K.; Pinto, Joaquim G.; Reyers, Mark; Klawa, Matthias

    2015-04-01

    During the last decades, several windstorm series hit Europe leading to large aggregated losses. Such storm series are examples of serial clustering of extreme cyclones, presenting a considerable risk for the insurance industry. Clustering of events and return periods of storm series affecting Europe are quantified based on potential losses using empirical models. Moreover, possible future changes of clustering and return periods of European storm series with high potential losses are quantified. Historical storm series are identified using 40 winters of NCEP reanalysis data (1973/1974 - 2012/2013). Time series of top events (1, 2 or 5 year return levels) are used to assess return periods of storm series both empirically and theoretically. Return periods of historical storm series are estimated based on the Poisson and the negative binomial distributions. Additionally, 800 winters of ECHAM5/MPI-OM1 general circulation model simulations for present (SRES scenario 20C: years 1960- 2000) and future (SRES scenario A1B: years 2060- 2100) climate conditions are investigated. Clustering is identified for most countries in Europe, and estimated return periods are similar for reanalysis and present day simulations. Future changes of return periods are estimated for fixed return levels and fixed loss index thresholds. For the former, shorter return periods are found for Western Europe, but changes are small and spatially heterogeneous. For the latter, which combines the effects of clustering and event ranking shifts, shorter return periods are found everywhere except for Mediterranean countries. These changes are generally not statistically significant between recent and future climate. However, the return periods for the fixed loss index approach are mostly beyond the range of preindustrial natural climate variability. This is not true for fixed return levels. The quantification of losses associated with storm series permits a more adequate windstorm risk assessment in a

  4. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) INCOME TAX (CONTINUED) INCOME TAXES Accounting Periods § 1.443-1 Returns for periods of less than 12...) Change of annual accounting period. In the case of a change in the annual accounting period of a taxpayer...-2. The computation of the tax for a short period required to effect a change of annual accounting...

  5. Determination of carbohydrate-deficient transferrin in human serum by capillary zone electrophoresis: evaluation of assay performance and quality assurance over a 10-year period in the routine arena.

    PubMed

    Joneli, Jeannine; Wanzenried, Ursula; Schiess, Jeannette; Lanz, Christian; Caslavska, Jitka; Thormann, Wolfgang

    2013-06-01

    The performance of high-resolution CZE for determination of carbohydrate-deficient transferrin (CDT) in human serum based on internal and external quality data gathered over a 10-year period is reported. The assay comprises mixing of serum with a Fe(III) ion-containing solution prior to analysis of the iron saturated mixture in a dynamically double-coated capillary using a commercial buffer at alkaline pH. CDT values obtained with a human serum of a healthy individual and commercial quality control sera are shown to vary less than 10%. Values of a control from a specific lot were found to slowly decrease as function of time (less than 10% per year). Furthermore, due to unknown reasons, gradual changes in the monitored pattern around pentasialo-transferrin were detected, which limit the use of commercial control sera of the same lot to less than 2 years. Analysis of external quality control sera revealed correct classification of the samples over the entire 10-year period. Data obtained compare well with those of HPLC and CZE assays of other laboratories. The data gathered over a 10-year period demonstrate the robustness of the high-resolution CZE assay. This is the first account of a CZE-based CDT assay with complete internal and external quality assessment over an extended time period.

  6. Changes in serum levels of perfluoroalkyl substances during a 10-year follow-up period in a large population-based cohort.

    PubMed

    Stubleski, Jordan; Salihovic, Samira; Lind, Lars; Lind, P Monica; van Bavel, Bert; Kärrman, Anna

    2016-10-01

    Poly- and perfluoroalkyl substances (PFASs) are a group of man-made fluorinated chemicals which have, at background levels, been associated with negative health effects in humans. Thus far, most human biomonitoring studies have evaluated the general change in PFAS concentration over time by continuously testing various individuals. This is one of the few studies to report the longitudinal trend of a range of PFAS concentrations in humans. In addition, this is the first known longitudinal study to include a large background level exposed cohort of both men and women with the same age and location who were repeatedly sampled from 2001 to 2014. The longitudinal change in concentration of eight PFASs detected in serum collected from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort were determined and compared to results from general population studies. The sex-dependent changes in PFAS concentrations over time were also assessed. Serum was sampled from the same individuals at ages 70 (collection period 2001-2004), 75 (2006-2009) and 80 (2011-2014,). Eight (C6-11) of fourteen (C4-13) analyzed PFASs were usually detected in over 75% of individuals and assessed using a random effects (mixed) model. In the 579 individuals attending all three examinations, PFOSA and PFOS concentrations significantly decreased, while the remaining six PFASs significantly increased between ages 70 and 75. However, between ages 75 and 80 all PFAS concentrations significantly decreased. Overall from age 70 to 80, concentrations of PFHxS, PFUnDA, PFNA, and PFDA showed a significant increase (7% to 34%), whereas concentrations of PFOSA, PFHpA, PFOS, and PFOA (-75% to -27%) significantly decreased. Over time PFHxS concentrations increased more among women, while PFHpA concentrations showed a greater decrease among men. From age 70 to age 80, spanning from 2001-2004 to 2011-2014, the PIVUS cohort showed decreases in circulating levels of some PFASs phased out of

  7. 7 CFR 273.32 - Households who return to TANF during the transitional period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS The Transitional Benefits Alternative § 273.32 Households who return to TANF during the transitional period. If a household receiving transitional benefits returns to...

  8. Return period adjustment for runoff coefficients based on analysis in undeveloped Texas watersheds

    USGS Publications Warehouse

    Dhakal, Nirajan; Fang, Xing; Asquith, William H.; Cleveland, Theodore G.; Thompson, David B.

    2013-01-01

    The rational method for peak discharge (Qp) estimation was introduced in the 1880s. The runoff coefficient (C) is a key parameter for the rational method that has an implicit meaning of rate proportionality, and the C has been declared a function of the annual return period by various researchers. Rate-based runoff coefficients as a function of the return period, C(T), were determined for 36 undeveloped watersheds in Texas using peak discharge frequency from previously published regional regression equations and rainfall intensity frequency for return periods T of 2, 5, 10, 25, 50, and 100 years. The C(T) values and return period adjustments C(T)/C(T=10  year) determined in this study are most applicable to undeveloped watersheds. The return period adjustments determined for the Texas watersheds in this study and those extracted from prior studies of non-Texas data exceed values from well-known literature such as design manuals and textbooks. Most importantly, the return period adjustments exceed values currently recognized in Texas Department of Transportation design guidance when T>10  years.

  9. Return period estimates for European windstorm clusters: a multi-model perspective

    NASA Astrophysics Data System (ADS)

    Renggli, Dominik; Zimmerli, Peter

    2017-04-01

    Clusters of storms over Europe can lead to very large aggregated losses. Realistic return period estimates for such cluster are therefore of vital interest to the (re)insurance industry. Such return period estimates are usually derived from historical storm activity statistics of the last 30 to 40 years. However, climate models provide an alternative source, potentially representing thousands of simulated storm seasons. In this study, we made use of decadal hindcast data from eight different climate models in the CMIP5 archive. We used an objective tracking algorithm to identify individual windstorms in the climate model data. The algorithm also computes a (population density weighted) Storm Severity Index (SSI) for each of the identified storms (both on a continental and more regional basis). We derived return period estimates for the cluster seasons 1990, 1999, 2013/2014 and 1884 in the following way: For each climate model, we extracted two different exceedance frequency curves. The first describes the exceedance frequency (or the return period as the inverse of it) of a given SSI level due to an individual storm occurrence. The second describes the exceedance frequency of the seasonally aggregated SSI level (i.e. the sum of the SSI values of all storms in a given season). Starting from appropriate return period assumptions for each individual storm of a historical cluster (e.g. Anatol, Lothar and Martin in 1999) and using the first curve, we extracted the SSI levels at the corresponding return periods. Summing these SSI values results in the seasonally aggregated SSI value. Combining this with the second (aggregated) exceedance frequency curve results in return period estimate of the historical cluster season. Since we do this for each model separately, we obtain eight different return period estimates for each historical cluster. In this way, we obtained the following return period estimates: 50 to 80 years for the 1990 season, 20 to 45 years for the 1999

  10. Stormwater Design Return Period Standards for U.S. Transportation Infrastructure: How Are States Approaching Resilience?

    NASA Astrophysics Data System (ADS)

    Samaras, C.; Lopez, T.

    2016-12-01

    Climate change is projected to increase the frequency and intensity of precipitation in many regions, which is relevant for stormwater engineering designs and resilience in the transportation sector. Existing and future stormwater infrastructure is generally designed for historical and stationary hydrologic conditions. For example, the design return period is based on statistical analysis of past precipitation events, often over a 50-year historical timeline. The design return period translates into how much peak precipitation volume a system is designed for in a state, and provides information about the performance of a drainage structure. The higher the design period used by an engineer for a given stormwater system, the more peak stormwater volume the system can convey. Therefore, design return periods can be associated with a design's near-term and long-term resilience. However, there is a tradeoff between the choice of design return period, the total infrastructure capital cost, and the resilience of a system to heavy precipitation events. This study analyzes current stormwater infrastructure design guidelines for state departments of transportation in the contiguous United States, in order to understand how stormwater design return periods vary across states and provide insight into the resilience of current stormwater systems design. The study found that the design return period varies considerably across the United States by roadway functional class and drainage classification, as well as within climate regions. Understanding this variation will help states identify possible vulnerabilities, highlight deficiencies across states and infrastructure types, and help in updating design return periods to increase the climate resilience of stormwater infrastructure.

  11. Note on a modified return period scale for upper-truncated unbounded flood distributions

    NASA Astrophysics Data System (ADS)

    Bardsley, Earl

    2017-01-01

    Probability distributions unbounded to the right often give good fits to annual discharge maxima. However, all hydrological processes are in reality constrained by physical upper limits, though not necessarily well defined. A result of this contradiction is that for sufficiently small exceedance probabilities the unbounded distributions anticipate flood magnitudes which are impossibly large. This raises the question of whether displayed return period scales should, as is current practice, have some given number of years, such as 500 years, as the terminating rightmost tick-point. This carries the implication that the scale might be extended indefinitely to the right with a corresponding indefinite increase in flood magnitude. An alternative, suggested here, is to introduce a sufficiently high upper truncation point to the flood distribution and modify the return period scale accordingly. The rightmost tick-mark then becomes infinity, corresponding to the upper truncation point discharge. The truncation point is likely to be set as being above any physical upper bound and the return period scale will change only slightly over all practical return periods of operational interest. The rightmost infinity tick point is therefore proposed, not as an operational measure, but rather to signal in flood plots that the return period scale does not extend indefinitely to the right.

  12. Estimation of return periods of multiple losses per winter associated with historical windstorm series over Germany

    NASA Astrophysics Data System (ADS)

    Karremann, Melanie; Pinto, Joaquim G.; von Bomhard, Philipp; Klawa, Matthias

    2014-05-01

    During the last decades, several windstorm series hit Western Europe leading to large cumulative economic losses. Such storm series are an example of serial clustering of extreme cyclones and present a considerable risk for the insurance industry. Here, clustering of events and return periods of storm series for Germany are quantified based on potential losses using empirical models. Two reanalysis datasets and observations from 123 German Weather Service stations are considered for the winters 1981/1982 to 2010/2011. Based on these datasets, histograms of events exceeding selected return levels (1-, 2- and 5-year) are derived. Return periods of historical storm series are estimated based on the Poisson and the negative Binomial distribution. About 4680 years of global circulation model simulations forced with current climate conditions are analysed to provide a better assessment of historical return periods. Estimations differ between the considered distributions. Except for frequent and weak events, the return period estimates obtained with the Poisson distribution clearly deviate from empirical data. This clearly documents overdispersion in the loss data, thus indicating the clustering of potential loss events. Better assessments are achieved for the negative Binomial distribution, e.g. 34 to 53 years for the storm series like 1989/1990. The overdispersion (clustering) of potential loss events clearly states the importance of an adequate risk assessment of multiple events per winter for economical applications.

  13. Return periods of extreme water levels estimated for some vulnerable areas of Buenos Aires

    NASA Astrophysics Data System (ADS)

    D'Onofrio, Enrique E.; Fiore, Monica M. E.; Romero, Silvia I.

    1999-10-01

    In Argentina, particularly in the province of Buenos Aires, densely populated areas are affected by swell inundations. This paper estimates the return periods of extreme levels, including those fixed by the Dirección Nacional de Planeamiento y Protección Civil (DNPPC) as evacuation warnings. The analysis combines the probability density functions (pdf) of tides and surges, provided their independence. The tidal pdf is generated from an hourly prediction for 19 yr. The surge pdf is obtained applying the generalized extreme value (GEV) distribution to a set of extreme surges generated by removing tides from a series of 89 yr of annual maxima. This set is chosen in order to make best use of the historical information since hourly water levels are not available for a long enough period. It is shown that in this case, the probability distribution which best fits to the surge data is that of Gumbel Type I. For an evacuation warning level of 3.30 m the estimated return period is 5 yr. The last 89 yr maximum (4.44 m) has a recurrence of approximately 265 yr. Estimated return periods are compared with those computed by the classical annual maxima method for the same period. The extreme levels and return periods estimated herein strongly justify the undertaking of actions in order to mitigate the serious consequences caused by floods in these low-lying areas.

  14. Spatial comparability of drought characteristics and related return periods in mainland China over 1961-2013

    NASA Astrophysics Data System (ADS)

    Ayantobo, Olusola O.; Li, Yi; Song, Songbai; Yao, Ning

    2017-07-01

    The proper understanding of the spatiotemporal characteristics of multi-year droughts and return periods is important for drought risk assessment. This study evaluated and compared the spatiotemporal variations of drought characteristics and return periods within mainland China between 1961 and 2013. Standardized Precipitation Index (SPI), Standardized Precipitation Evapotranspiration Index (SPEI) and Composite Index (CI) were calculated at multiple timescales, the run theory was used for objective identification and characterization of drought events while Kendall's τ method was used to analyze their dependencies. Within the univariate framework, marginal distributions of duration, severity, and peak were derived by fitting Exponential, Weibull and GDP distributions respectively and the drought return periods was investigated and mapped. Comparison of drought indices showed that SPEI and CI performed better than SPI in delineating spatial patterns of drought characteristics. This might be attributed to the temperature effect on evapotranspiration and therefore on drought index. Considering the increasing trend in reference evapotranspiration in the 21st century, the importance of utilizing temperature-based drought index is imperative. Severe and extreme droughts occurred in the late 1990s in many places in China while persistent multi-year severe droughts occurred more frequently over North China, Northeast China, Northwest China and Southwest China. The spatial patterns showed that regions characterized by higher drought severity were associated with higher drought duration. The North China, Northwest China, and Southwest China had much longer drought durations during the 1990s and 2000s. As droughts normally cover large areas, regional drought return periods has been showed to be more effective in providing support for drought management than station based drought return periods. Studies on the spatial comparability of drought return periods across mainland

  15. The return period analysis of natural disasters with statistical modeling of bivariate joint probability distribution.

    PubMed

    Li, Ning; Liu, Xueqin; Xie, Wei; Wu, Jidong; Zhang, Peng

    2013-01-01

    New features of natural disasters have been observed over the last several years. The factors that influence the disasters' formation mechanisms, regularity of occurrence and main characteristics have been revealed to be more complicated and diverse in nature than previously thought. As the uncertainty involved increases, the variables need to be examined further. This article discusses the importance and the shortage of multivariate analysis of natural disasters and presents a method to estimate the joint probability of the return periods and perform a risk analysis. Severe dust storms from 1990 to 2008 in Inner Mongolia were used as a case study to test this new methodology, as they are normal and recurring climatic phenomena on Earth. Based on the 79 investigated events and according to the dust storm definition with bivariate, the joint probability distribution of severe dust storms was established using the observed data of maximum wind speed and duration. The joint return periods of severe dust storms were calculated, and the relevant risk was analyzed according to the joint probability. The copula function is able to simulate severe dust storm disasters accurately. The joint return periods generated are closer to those observed in reality than the univariate return periods and thus have more value in severe dust storm disaster mitigation, strategy making, program design, and improvement of risk management. This research may prove useful in risk-based decision making. The exploration of multivariate analysis methods can also lay the foundation for further applications in natural disaster risk analysis.

  16. Spatial estimation of debris flows-triggering rainfall and its dependence on rainfall return period

    NASA Astrophysics Data System (ADS)

    Destro, Elisa; Marra, Francesco; Nikolopoulos, Efthymios I.; Zoccatelli, Davide; Creutin, Jean Dominique; Borga, Marco

    2017-02-01

    Forecasting the occurrence of debris flows is fundamental for issuing hazard warnings, and often focuses on rainfall as a triggering agent and on the use of empirical rainfall thresholds based on rain gauge observations. A recognized component of the uncertainty associated with the use of rainfall thresholds is related to the sampling of strongly varying rainfall variability with sparse rain gauge networks. In this work we examine the spatial distribution of rainfall depth in areas up to 10 km from the debris flow initiation points as a function of return period, and we exploit this information to analyze the errors expected in the estimation of debris flow triggering rainfall when rain gauge data are used. In particular, we investigate the impact of rain gauge density and of the use of different interpolation methods. High-resolution, adjusted radar rainfall estimates, representing the best available spatially-distributed rainfall estimates at the debris flows initiation point and in the surrounding area, are sampled by stochastically generated rain gauge networks characterized by varying densities. Debris flow triggering rainfall is estimated by means of three rainfall interpolation methods: nearest neighbor, inverse distance weighting and ordinary kriging. On average, triggering rainfall shows a local peak corresponding to the debris flow initiation point, with a decay of rainfall with distance which increases with the return period of the triggering rainfall. Interpolation of the stochastically generated rain gauge measurements leads to an underestimation of the triggering rainfall that, irrespective of the interpolation methods, increases with the return period and decreases with the rain gauge density. For small return period events and high rain gauge density, the differences among the methods are minor. With increasing the return period and decreasing the rain gauge density, the nearest neighbor method is less biased, because it makes use only of the

  17. True fir spacing trials: 10-year results.

    Treesearch

    Robert O. Curtis

    2008-01-01

    Eighteen precommercial thinning trials were established in true fir-hemlock stands in the Olympic Mountains and the west side of the Cascade Range during the period 1987 through 1994. This paper updates a previous report, with results for the first 10 years after establishment. Results are given for (1) all trees, (2) the largest 80 per acre of any species, and (3)...

  18. Family Resource Coalition: 10 Years.

    ERIC Educational Resources Information Center

    Family Resource Coalition Report, 1991

    1991-01-01

    This newsletter issue focuses on the 10 years of leadership provided by the Family Resource Coalition in the support of families. The centerpiece of this anniversary issue is an interview with Coalition founder and President Bernice Weissbourd, exploring how the original ideas of the family resource movement have been implemented over the past 10…

  19. Estimation of the return period of rockfall blocks according to their size

    NASA Astrophysics Data System (ADS)

    De Biagi, Valerio; Lia Napoli, Maria; Barbero, Monica; Peila, Daniele

    2017-01-01

    With reference to the rockfall risk estimation and the planning of rockfall protection devices, one of the most critical and most discussed problems is the correct definition of the design block by taking into account its return period. In this paper, a methodology for the assessment of the design block linked with its return time is proposed and discussed, following a statistical approach. The procedure is based on the survey of the blocks that were already detached from the slope and had accumulated at the foot of the slope in addition to the available historical data.

  20. How are flood risk estimates affected by the choice of return-periods?

    NASA Astrophysics Data System (ADS)

    Ward, P. J.; Aerts, J. C. J. H.; De Moel, H.; Poussin, J. K.

    2012-04-01

    Flood management is more and more adopting a risk based approach, whereby flood risk is the product of the probability and consequences of flooding. One of the most common approaches in flood risk assessment is to estimate the damage that would occur for floods of several exceedance probabilities (or return periods), to plot these on an exceedance probability-loss curve (risk curve) and to estimate risk as the area under the curve. However, there is little insight into how the selection of the return-periods (which ones and how many) used to calculate risk actually affects the final risk calculation. To gain such insights, we developed and validated an inundation model capable of rapidly simulating inundation extent and depth, and dynamically coupled this to an existing damage model. The method was applied to a section of the River Meuse in the southeast of the Netherlands. Firstly, we estimated risk based on a risk curve using yearly return periods from 2 to 10 000 yr (€ 34 million p.a.). We found that the overall risk is greatly affected by the number of return periods used to construct the risk curve, with over-estimations of annual risk between 33% and 100% when only three return periods are used. Also, the final risk estimate is greatly dependent on the minimum and maximum return periods (and their associated damages) used in the construction of the risk curve. In addition, binary assumptions on dike failure can have a large effect (a factor two difference) on risk estimates. The results suggest that more research is needed to develop relatively simple inundation models that can be used to produce large numbers of inundation maps, complementary to more complex 2D-3D hydrodynamic models. We then used the insights and models described above to assess the relative change in risk between current conditions and several scenarios of land use and climate change. For the case study region, we found that future land use change has a larger impact than future climate

  1. Bivariate return periods of temperature and precipitation explain a large fraction of European crop yields

    NASA Astrophysics Data System (ADS)

    Zscheischler, Jakob; Orth, Rene; Seneviratne, Sonia I.

    2017-07-01

    Crops are vital for human society. Crop yields vary with climate and it is important to understand how climate and crop yields are linked to ensure future food security. Temperature and precipitation are among the key driving factors of crop yield variability. Previous studies have investigated mostly linear relationships between temperature and precipitation and crop yield variability. Other research has highlighted the adverse impacts of climate extremes, such as drought and heat waves, on crop yields. Impacts are, however, often non-linearly related to multivariate climate conditions. Here we derive bivariate return periods of climate conditions as indicators for climate variability along different temperature-precipitation gradients. We show that in Europe, linear models based on bivariate return periods of specific climate conditions explain on average significantly more crop yield variability (42 %) than models relying directly on temperature and precipitation as predictors (36 %). Our results demonstrate that most often crop yields increase along a gradient from hot and dry to cold and wet conditions, with lower yields associated with hot and dry periods. The majority of crops are most sensitive to climate conditions in summer and to maximum temperatures. The use of bivariate return periods allows the integration of non-linear impacts into climate-crop yield analysis. This offers new avenues to study the link between climate and crop yield variability and suggests that they are possibly more strongly related than what is inferred from conventional linear models.

  2. Bivariate return periods of temperature and precipitation explain a large fraction of European crop yields

    NASA Astrophysics Data System (ADS)

    Zscheischler, Jakob; Orth, Rene; Seneviratne, Sonia I.

    2017-04-01

    Crops are vital for human society. Crop yields vary with climate and it is important to understand how climate and crop yields are linked to ensure future food security. Temperature and precipitation are among the key driving factors of crop yield variability. Previous studies have investigated mostly linear relationships between temperature and precipitation, and crop yields variability. Other research has highlighted the adverse impacts of climate extremes such as drought and heat waves on crop yields. Impacts are, however, often non-linearly related to multivariate climate conditions. Here we derive bivariate return periods of climate conditions as indicators for climate variability along different temperature-precipitation gradients. We show that in Europe, linear models based on bivariate return periods of specific climate conditions explain on average significantly more crop yield variability (42%) than models relying directly on temperature and precipitation as predictors (36%). Our results demonstrate that most often crop yields increase along a gradient from hot and dry, to cold and wet conditions with lower yields associated with hot and dry periods. The majority of crops are most sensitive to climate conditions in summer and to maximum temperatures. The use of bivariate return periods allows the integration of nonlinear impacts into climate-crop yield analysis. This offers new avenues to study the link between climate and crop yield variability and suggests that they are possibly more strongly related than what is inferred from conventional linear models.

  3. The introduction of DRG funding and hospital nurses' changing perceptions of their practice environment, quality of care and satisfaction: comparison of cross-sectional surveys over a 10-year period.

    PubMed

    Zander, Britta; Dobler, Lydia; Busse, Reinhard

    2013-02-01

    As other countries which have introduced diagnosis-related groups (DRGs) to pay their hospitals Germany initially expected that quality of care could deteriorate. Less discussed were potential implications for nurses, who might feel the efficiency-increasing effects of DRGs on their daily work, which in turn may lead to an actual worsening of care quality. To analyze whether the DRG implementation in German acute hospitals (as well as other changes over the 10-year period) had measurable effects on (1) the nurse work environment (including e.g. an adequate number of nursing staff to provide quality patient care), (2) quality of patient care and safety (incl. confidence into patients' ability to manage care when discharged), and (3) whether the effects from (1) and (2)--if any--impacted on the nurses themselves (satisfaction with their current job and their choice of profession as well as emotional exhaustion). Two rounds of nurse surveys with the Practice Environment Scale of the Nursing Work Index (PES-NWI), five years before DRG implementation (i.e. in 1998/1999; n=2681 from 29 hospitals) and five years after (i.e. in 2009/2010; n=1511 from 49 hospitals). The analysis utilized 15 indicators as outcomes for (1) practice environment, (2) quality of patient care and safety, as well as (3) nurses' satisfaction and emotional exhaustion. Multivariate analyses were performed for all three sets of outcomes using SPSS version 20. Aspects of the practice environment (especially adequate staffing and supportive management) worsened within the examined time span of 10 years, which as a consequence had significant negative impact on the nurse-perceived quality of care (except for patient safety, which improved). Both the aspects of the practice environment and the quality aspects impacted substantially on satisfaction and emotional exhaustion among nurses. The DRG implementation in Germany has apparently had measurable negative effects on nurses and nurse-perceived patient

  4. A new method to estimate wave height of specified return period

    NASA Astrophysics Data System (ADS)

    Wang, Liping; Xu, Xin; Liu, Guilin; Chen, Baiyu; Chen, Zhengshou

    2016-09-01

    In this paper, we propose a new method to estimate the wave height of a specific return period based on the Hurst rule and a self-affine fractal formula. A detailed description of our proposed model is presented in this paper. We use the proposed model to analyze wave height data recorded along the coast of Chaolian Island from 1963 to 1989. The results show that the performance of our proposed model in estimating design wave heights is superior to traditional models.

  5. The dual effect of vegetation green-up date and strong wind on the return period of spring dust storms.

    PubMed

    Feng, Jieling; Li, Ning; Zhang, Zhengtao; Chen, Xi

    2017-08-15

    Vegetation phenology changes have been widely applied in the disaster risk assessments of the spring dust storms, and vegetation green-up date shifts have a strong influence on dust storms. However, the effect of earlier vegetation green-up dates due to climate warming on the evaluation of dust storms return periods remains an important, but poorly understood issue. In this study, we evaluate the spring dust storm return period (February to June) in Inner Mongolia, Northern China, using 165 observations of severe spring dust storm events from 16 weather stations, and regional vegetation green-up dates as an integrated factor from NDVI (Normalized Difference Vegetation Index), covering a period from 1982 to 2007, by building the bivariate Copula model. We found that the joint return period showed better fitting results than without considering the integrated factor when the actual dust storm return period is longer than 2years. Also, for extremely severe dust storm events, the gap between simulation result and actual return period can be narrowed up to 0.4888years by using integrated factor. Furthermore, the risk map based on the return period results shows that the Mandula, Zhurihe, Sunitezuoqi, Narenbaolige stations are identified as high risk areas. In this study area, land surface is extensively covered by grasses and shrubs, vegetation green-up date can play a significant role in restraining spring dust storm outbreaks. Therefore, we suggest that Copula method can become a useful tool for joint return period evaluation and risk analysis of severe dust storms.

  6. Swift: 10 Years of Discovery

    NASA Astrophysics Data System (ADS)

    The conference Swift: 10 years of discovery was held in Roma at La Sapienza University on Dec. 2-5 2014 to celebrate 10 years of Swift successes. Thanks to a large attendance and a lively program, it provided the opportunity to review recent advances of our knowledge of the high-energy transient Universe both from the observational and theoretical sides. When Swift was launched on November 20, 2004, its prime objective was to chase Gamma-Ray Bursts and deepen our knowledge of these cosmic explosions. And so it did, unveiling the secrets of long and short GRBs. However, its multi-wavelength instrumentation and fast scheduling capabilities made it the most versatile mission ever flown. Besides GRBs, Swift has observed, and contributed to our understanding of, an impressive variety of targets including AGNs, supernovae, pulsars, microquasars, novae, variable stars, comets, and much more. Swift is continuously discovering rare and surprising events distributed over a wide range of redshifts, out to the most distant transient objects in the Universe. Such a trove of discoveries has been addressed during the conference with sessions dedicated to each class of events. Indeed, the conference in Rome was a spectacular celebration of the Swift 10th anniversary. It included sessions on all types of transient and steady sources. Top scientists from around the world gave invited and contributed talks. There was a large poster session, sumptuous lunches, news interviews and a glorious banquet with officials attending from INAF and ASI. All the presentations, as well as several conference pictures, can be found in the conference website (http://www.brera.inaf.it/Swift10/Welcome.html). These proceedings have been collected owing to the efforts of Paolo D’Avanzo who has followed each paper from submission to final acceptance. Our warmest thanks to Paolo for all his work. The Conference has been made possible by the support from La Sapienza University as well as from the ARAP

  7. Determination of return period for flood frequency analysis using normal and related distributions

    NASA Astrophysics Data System (ADS)

    Deraman, Wan Husna Aini Wan; Mutalib, Noor Julailah Abd; Zahidah Mukhtar, Nur

    2017-09-01

    Flood frequency analyses are used to predict design floods for sites along a river. The technique involves using the observed annual maximum rainfall depths data to calculate statistical information such as mean values, standard deviations, skewness, and recurrence intervals. This research is to determine the return period for annual maximum rainfall depths data for two sites in Kemaman, which Jabor and Air Putih. All the data at two sites of study area are yearly data and the data of rainfall depths are taken starting from 1985 until 2015. The distributions used in this study are Normal, two-parameter Lognormal (LN(2)) and three-parameter Lognormal (LN(3)) distributions. The first step is to find the parameter estimates of rainfall depths in these two sites for each distribution. The parameters are estimated using the Method of Moments (MOM) and Probability Weighted Moments (PWM). Then, the best methods for each distribution in each site are obtained by using the performance measurements. Based on the best method for each distribution, the comparisons for the best method for each site are made. The results show that the best distribution that fits the characteristics of performance indicators for Jabor and Air Putih are two-parameter Lognormal distribution and three-parameter Lognormal distribution, respectively. Then, the last step is to determine the return period for the best distribution for 2, 5, 10, 50 and 100 years. Lastly, for the return period of 2, 5, 10, 50, 100 years, it can be concluded that Jabor has the higher annual maximum rainfall depths than Air Putih.

  8. Return Period and Risk of Extreme Sea Levels under Non-Stationarity

    NASA Astrophysics Data System (ADS)

    Obeysekera, J.; Salas, J. D.

    2014-12-01

    Heavily populated urban centers and natural areas located in low lying coastal regions are highly vulnerable to sea level extremes. Current practice of using probabilistic methods for predicting future sea level extremes is based on concepts of return period and risk that have been developed under stationarity conditions. Recently, similar concepts under non-stationary conditions have been developed and a paradigm shift is needed to incorporate the newer concepts into practice. Current projections of future sea levels include varying degrees of acceleration with significant uncertainty and often alternative scenarios are considered on a risk-based framework for planning coastal infrastructure. Extension of the traditional concepts of return period and risk into a non-stationary framework is demonstrated by assuming a probability distribution of extreme values that is parameterized as a function of time. Specifically, the Generalized Extreme Value distribution with time-varying parameters has been applied for fitting the distribution of extreme sea level data. The scenario based projection of mean sea level is linked to the location parameter of the extreme value distribution. This allows the estimation of return period and risk associated with future sea levels in a changing world where mean sea level is expected to be accelerating. Confidence intervals for the projections of extreme sea levels using the new paradigm are also presented. The methodology presented here as demonstrated using the data from few tide gages can be used for planning and design of coastal infrastructure in a changing climate. The presentation ends with a discussion of a number of relevant issues involved in considering non-stationarity in planning and design of coastal projects.

  9. Challenges estimating the return period of extreme floods for reinsurance applications

    NASA Astrophysics Data System (ADS)

    Raven, Emma; Busby, Kathryn; Liu, Ye

    2013-04-01

    Mapping and modelling extreme natural events is fundamental within the insurance and reinsurance industry for assessing risk. For example, insurers might use a 1 in 100-year flood hazard map to set the annual premium of a property, whilst a reinsurer might assess the national scale loss associated with the 1 in 200-year return period for capital and regulatory requirements. Using examples from a range of international flood projects, we focus on exploring how to define what the n-year flood looks like for predictive uses in re/insurance applications, whilst considering challenges posed by short historical flow records and the spatial and temporal complexities of flood. First, we shall explore the use of extreme value theory (EVT) statistics for extrapolating data beyond the range of observations in a marginal analysis. In particular, we discuss how to estimate the return period of historical flood events and explore the impact that a range of statistical decisions have on these estimates. Decisions include: (1) selecting which distribution type to apply (e.g. generalised Pareto distribution (GPD) vs. generalised extreme value distribution (GEV)); (2) if former, the choice of the threshold above which the GPD is fitted to the data; and (3) the necessity to perform a cluster analysis to group flow peaks to temporally represent individual flood events. Second, we summarise a specialised multivariate extreme value model, which combines the marginal analysis above with dependence modelling to generate industry standard event sets containing thousands of simulated, equi-probable floods across a region/country. These events represent the typical range of anticipated flooding across a region and can be used to estimate the largest or most widespread events that are expected to occur. Finally, we summarise how a reinsurance catastrophe model combines the event set with detailed flood hazard maps to estimate the financial cost of floods; both the full event set and also

  10. [The role of skin substitutes in the surgical treatment of extensive burns covering more than 60 % of total body surface area. A review of patients over a 10-year period at the Tours University Hospital].

    PubMed

    Lamy, J; Yassine, A-H; Gourari, A; Forme, N; Zakine, G

    2015-04-01

    Progress in intensive care and surgery has made it possible to significantly improve the survival of victims with burns over 60% of total body surface area (TBSA). Coverage of the excised areas of these patients can be difficult when there is a shortage of skin donor sites; then the role of skin substitutes can be important. This retrospective study included patients with burns covering more than 60% TBSA and treated at the Tours University Hospital over a period of 10 years. Patients who died during the first week or who presented superficial burns were excluded. The various substitutions means to temporarily or permanently replace the cutaneous barrier are presented. The biological dressings associated with grafts expanded by six according to the sandwich technique, allografts and xenografts, widely expanded postage stamp skin grafts using a modified Meek technique (Humeca(®)), temporary cutaneous substitutes such as Biobrane(®) and skin substitutes colonized by autologous cells (Integra(®)) are presented. Forty-four patients were admitted. Self-immolations represented 52% of the cases. Twenty-one patients were treated with Integra(®), 5 with Biobrane(®), 17 with sandwich grafts and 4 with postage stamp skin grafts. Integra(®) was widely used when donor sites were insufficient. The mean number of surgical procedures per patient was 8.4. The mean duration of hospitalization was 155 days. Twenty-four patients survived until the end of treatment. Eighteen patients died during the first week before any surgery could be performed. Two patients died at the end of treatment. The overall survival rate was 55%. It was 92% for patients who survived the first week. The principal sequel were functional (hand, cervical, thoracic and axillary contractures) and aesthetic (face and hands). Associated treatments were pressotherapy, physical therapy, ergotherapy and thermal water therapy. By temporarily replacing the cutaneous barrier in the absence of sufficient donor sites

  11. Studies of phase return map and symbolic dynamics in a periodically driven Hodgkin—Huxley neuron

    NASA Astrophysics Data System (ADS)

    Ding, Jiong; Zhang, Hong; Tong, Qin-Ye; Chen, Zhuo

    2014-02-01

    How neuronal spike trains encode external information is a hot topic in neurodynamics studies. In this paper, we investigate the dynamical states of the Hodgkin—Huxley neuron under periodic forcing. Depending on the parameters of the stimulus, the neuron exhibits periodic, quasiperiodic and chaotic spike trains. In order to analyze these spike trains quantitatively, we use the phase return map to describe the dynamical behavior on a one-dimensional (1D) map. According to the monotonicity or discontinuous point of the 1D map, the spike trains are transformed into symbolic sequences by implementing a coarse-grained algorithm — symbolic dynamics. Based on the ordering rules of symbolic dynamics, the parameters of the external stimulus can be measured in high resolution with finite length symbolic sequences. A reasonable explanation for why the nervous system can discriminate or cognize the small change of the external signals in a short time is also presented.

  12. Estimation of extreme precipitation; Return period values and PMP for Norway

    NASA Astrophysics Data System (ADS)

    Engen-Skaugen, Torill; Alfnes, Eli; Førland, Eirik J.

    2010-05-01

    Estimates of extreme values of precipitation represented as return period values and Probable Maximum Precipitation (PMP) are frequently used in flood evaluation as well as dimensioning of hydro power dams. The estimates are also of interest for infrastructure constructions (e.g. urban runoff). The estimates establish a reference to how rare a heavy rainfall event at a location is. This study presents present-day and future return period values and PMP estimates for several catchments in Norway. Daily precipitation values are extracted from grids covering the Norwegian mainland, spatial resolution 1 x 1 km2, for the time period 1957 - 2009. The grids are interpolated from observations at all available rain gage stations operated by the Norwegian Meteorolgoical Institute in Norway. The maps can be seen at http://senorge.no (Mohr, 2009; Jansson et al., 2007). The rain gauge network in the high mountain region is sparse, leading to reduced quality in these regions. A rough correction of daily gauge precipitation for undercatch because of wind exposure is performed before interpolation. Six climate projections downscaled with different Regional Climate Models (RCMs) are adjusted to be representative locally for the Norwegian mainland (Engen-Skaugen, 2007). Daily precipitation projections are established for the same grid extent as for observations. Time series of daily precipitation are then extracted from these grids representing the same catchments as the historic data. The estimates of extreme precipitation are based on daily precipitation values (Førland, 1992; Alfnes, 2007). Instead of producing area estimates based on site values adjusted by an Area Reduction Factor (ARF), area estimates in the present study is based on time series of daily precipitation representing the actual catchments extracted from the high resolution grids. Alfnes (2007) found that the five-year return value estimates (M5) for these two methods were similar, with exceptions for catchments

  13. 10-year survival of total ankle arthroplasties

    PubMed Central

    2011-01-01

    Background and purpose There is an ongoing need to review large series of total ankle replacements (TARs) for monitoring of changes in practice and their outcome. 4 national registries, including the Swedish Ankle Register, have previously reported their 5-year results. We now present an extended series with a longer follow-up, and with a 10-year survival analysis. Patients and methods Records of uncemented 3-component TARs were retrospectively reviewed, determining risk factors such as age, sex, and diagnosis. Prosthetic survival rates were calculated with exchange or removal of components as endpoint—excluding incidental exchange of the polyethylene meniscus. Results Of the 780 prostheses implanted since 1993, 168 (22%) had been revised by June 15, 2010. The overall survival rate fell from 0.81 (95% CI: 0.79–0.83) at 5 years to 0.69 (95% CI: 0.67–0.71) at 10 years. The survival rate was higher, although not statistically significantly so, during the latter part of the period investigated. Excluding the STAR prosthesis, the survival rate for all the remaining designs was 0.78 at 10 years. Women below the age of 60 with osteoarthritis were at a higher risk of revision, but age did not influence the outcome in men or women with rheumatoid arthritis. Revisions due to technical mistakes at the index surgery and instability were undertaken earlier than revisions for other reasons. Interpretation The results have slowly improved during the 18-year period investigated. However, we do not believe that the survival rates of ankle replacements in the near future will approach those of hip and knee replacements—even though improved instrumentation and design of the prostheses, together with better patient selection, will presumably give better results. PMID:22066551

  14. Estimating return periods for daily precipitation extreme events over the Brazilian Amazon

    NASA Astrophysics Data System (ADS)

    Santos, Eliane Barbosa; Lucio, Paulo Sérgio; Santos e Silva, Cláudio Moisés

    2016-11-01

    This paper aims to model the occurrence of daily precipitation extreme events and to estimate the return period of these events through the extreme value theory (generalized extreme value distribution (GEV) and the generalized Pareto distribution (GPD)). The GEV and GPD were applied in precipitation series of homogeneous regions of the Brazilian Amazon. The GEV and GPD goodness of fit were evaluated by quantile-quantile (Q-Q) plot and by the application of the Kolmogorov-Smirnov (KS) test, which compares the cumulated empirical distributions with the theoretical ones. The Q-Q plot suggests that the probability distributions of the studied series are appropriated, and these results were confirmed by the KS test, which demonstrates that the tested distributions have a good fit in all sub-regions of Amazon, thus adequate to study the daily precipitation extreme event. For all return levels studied, more intense precipitation extremes is expected to occur within the South sub-regions and the coastal area of the Brazilian Amazon. The results possibly will have some practical application in local extreme weather forecast.

  15. Multivariate multiparameter extreme value models and return periods: A copula approach

    NASA Astrophysics Data System (ADS)

    Salvadori, G.; de Michele, C.

    2010-10-01

    Multivariate extreme value models are a fundamental tool in order to assess potentially dangerous events. The target of this paper is two-fold. On the one hand we outline how, exploiting recent theoretical developments in the theory of copulas, new multivariate extreme value distributions can be easily constructed; in particular, we show how a suitable number of parameters can be introduced, a feature not shared by traditional extreme value models. On the other hand, we introduce a proper new definition of multivariate return period and show the differences with (and the advantages over) the definition presently used in literature. An illustration involving flood data is presented and discussed, and a generalization of the well-known multivariate logistic Gumbel model is also given.

  16. Examining Insurance Loss Return Periods with Extreme Event Intensity Thresholds across the US: 1980-2010

    NASA Astrophysics Data System (ADS)

    Smith, A. B.

    2010-12-01

    To improve the “effectiveness” of NOAA storm event information for risk managers, planners, policy makers and public safety, NOAA’s NCDC is integrating U.S. hazards/exposure data with respective insurance loss return periods. This is performed by calculating county-level extreme event intensity thresholds using these data types: hurricanes (NHC), winter storms (NESIS/RESIS), tornadoes (SPC; SWDI), hail (SPC; SWDI), high winds (SPC), drought (USDM/NIDIS), and U.S. insurance loss datasets (Munich Re, USDA-RMA, PCS, FEMA). This research also utilizes NWS warning data, socioeconomic data from the Bureau of Economic Analysis (BEA), and U.S. Census data (e.g., gridded population/density, mean housing value, per capita income, production wealth) to normalize for increases in population, inflation, and wealth. This work seeks to establish county-level U.S. extreme event economic risk climatologies for the period 1980-2010. This research will inform a new derived risk data product to improve information on extreme event loss frequencies and clustering across time and space horizons. Acronyms: FEMA: Federal Emergency Management Administration NESIS: Northeast Snowfall Impact Scale NHC: (NOAA) National Hurricane Center NIDIS: National Integrated Drought Information System PCS: Property Claim Services RESIS: Regional Snowfall Impact Scale SPC: (NOAA) Storm Prediction Center SWDI: (NOAA) Severe Weather Data Inventory USDA-RMA: U.S. Department of Agriculture - Risk Management Agency USDM: U.S. Drought Monitor

  17. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... taxable year. For annual accounting periods beginning after December 31, 1962, see § 1.6038-2. (b) Control... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Information returns required of domestic corporations with respect to annual accounting periods of certain foreign corporations beginning before...

  18. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... taxable year. For annual accounting periods beginning after December 31, 1962, see § 1.6038-2. (b) Control... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Information returns required of domestic corporations with respect to annual accounting periods of certain foreign corporations beginning before...

  19. Evaluation of the return periods of water crises and evaporation in Monte Cotugno reservoir (Southern Italy)

    NASA Astrophysics Data System (ADS)

    Copertino, Vito; Lo Vecchio, Giuseppina; Marotta, Lucia; Pastore, Vittoria; Ponzio, Giuseppe; Scavone, Giuseppina; Telesca, Vito; Vita, Michele

    2010-05-01

    In the past water resources management has been dealt and solved increasing water availabilities; today such opportunities have been considerably reduced and the technical-scientific perspectives are addressed above all to improve water system effectiveness and to promote an use of water resources that holds account of the droughts frequency and based on a correct estimate of the hydrologic balance. In this work a study on the water stored in Monte Cotugno reservoir in Sinni river - Basilicata (Southern Italy) - is proposed, estimating water crises return periods and reservoir evaporation. For such purpose the runs method was applied, based on the comparison between the temporal series of the "water volume" hydrological variable and a threshold representative of the "normal" conditions regarding which the availability in excess or defect was estimated. This allowed to individualize the beginning and the end of a water crisis event and to characterize the droughts in terms of duration, sum deficit and intensity. Therefore the return period was evaluated by means of the methodology proposed by Shiau and Shen in 2001, turned out equal approximately to 6 years. Such value was then verified with a frequency analysis of the "water volume" random variable, using the Weibull's distribution. Subsequently, the Fourier's analysis in the last twenty years was carried out, obtaining the same result of the previous methods. Moreover, in proximity of the Monte Cotugno reservoir the weather station of Senise is located, managed by ALSIA (Agenzia Lucana di Sviluppo e Innovazione in Agricultura), that provides in continuous measurements of air temperature and humidity, wind speed and direction, and global solar radiation since 2000. Such parameters allowed to apply five methods for reservoir evaporation estimate selected from those proposed in the literature, of which the first three, the Jensen-Haise's method, Makkink's method and Stephens-Stewart's one are based on solar radiation

  20. Estimating return periods of extreme values from relatively short time series of winds

    NASA Astrophysics Data System (ADS)

    Jonasson, Kristjan; Agustsson, Halfdan; Rognvaldsson, Olafur; Arfeuille, Gilles

    2013-04-01

    An important factor for determining the prospect of individual wind farm sites is the frequency of extreme winds at hub height. Here, extreme winds are defined as the value of the highest 10 minutes averaged wind speed with a 50 year return period, i.e. annual exceeding probability of 2% (Rodrigo, 2010). A frequently applied method to estimate winds in the lowest few hundred meters above ground is to extrapolate observed 10-meter winds logarithmically to higher altitudes. Recent study by Drechsel et al. (2012) showed however that this methodology is not as accurate as interpolating simulated results from the global ECMWF numerical weather prediction (NWP) model to the desired height. Observations of persistent low level jets near Colima in SW-Mexico also show that the logarithmic approach can give highly inaccurate results for some regions (Arfeuille et al., 2012). To address these shortcomings of limited, and/or poorly representative, observations and extrapolations of winds one can use NWP models to dynamically scale down relatively coarse resolution atmospheric analysis. In the case of limited computing resources one has typically to make a compromise between spatial resolution and the duration of the simulated period, both of which can limit the quality of the wind farm siting. A common method to estimate maximum winds is to fit an extreme value distribution (e.g. Gumbel, gev or Pareto) to the maximum values of each year of available data, or the tail of these values. If data are only available for a short period, e.g. 10 or 15 years, then this will give a rather inaccurate estimate. It is possible to deal with this problem by utilizing monthly or weekly maxima, but this introduces new problems: seasonal variation, autocorrelation of neighboring values, and increased discrepancy between data and fitted distribution. We introduce a new method to estimate return periods of extreme values of winds at hub height from relatively short time series of winds, simulated

  1. The global tsunami hazard due to long return period subduction zone earthquakes

    NASA Astrophysics Data System (ADS)

    Løvholt, Finn; Bonnevie Harbitz, Carl; Glimsdal, Sylfest; Horspool, Nick; Smebye, Helge; de Bono, Andrea; Nadim, Farrokh

    2014-05-01

    Historical tsunamis and paleotsunami evidence indicate that massive megathrust earthquakes lead to the majority of the losses due to tsunamis. There is a need to quantify the tsunami hazard from megathrust events in order to compare tsunamis with other natural hazards on a global level, as previous attempts have been lacking. The global tsunami hazard induced by earthquakes is therefore computed for a return period of 500 years. To this end, the exposed elements at risk such as population, produced capital, and nuclear power plants are determined. It is shown that populous Asian countries account for the largest absolute number of people living in tsunami prone areas, more than 50% of the total exposed people live in Japan. Smaller nations like Macao and the Maldives are among the most exposed by population count. Exposed nuclear power plants are limited to Japan, China, India, Taiwan, and USA. The methods used to quantify the global hazard are obviously crude, and hence the expected accuracy using global methods are discussed.

  2. Investigation of the relation between the return periods of major drought characteristics using copula functions

    NASA Astrophysics Data System (ADS)

    Hüsami Afşar, Mehdi; Unal Şorman, Ali; Tugrul Yilmaz, Mustafa

    2016-04-01

    Different drought characteristics (e.g. duration, average severity, and average areal extent) often have monotonic relation that increased magnitude of one often follows a similar increase in the magnitude of the other drought characteristic. Hence it is viable to establish a relationship between different drought characteristics with the goal of predicting one using other ones. Copula functions that relate different variables using their joint and conditional cumulative probability distributions are often used to statistically model the drought characteristics. In this study bivariate and trivariate joint probabilities of these characteristics are obtained over Ankara (Turkey) between 1960 and 2013. Copula-based return period estimation of drought characteristics of duration, average severity, and average areal extent show joint probabilities of these characteristics can be satisfactorily achieved. Among different copula families investigated in this study, elliptical family (i.e. including normal and t-student copula functions) resulted in the lowest root mean square error. "This study was supported by TUBITAK fund #114Y676)."

  3. Development of Return Period Inundation Maps In A Changing Climate Using a Systems of Systems Approach

    NASA Astrophysics Data System (ADS)

    Bilskie, M. V.; Hagen, S. C.; Alizad, K.; Passeri, D. L.; Irish, J. L.

    2016-12-01

    Worldwide, coastal land margins are experiencing increased vulnerability from natural and manmade disasters [Nicholls et al., 1999]. Specifically, coastal flooding is expected to increase due to the effects of climate change, and sea level rise (SLR) in particular. A systems of systems (SoS) approach has been implemented to better understand the dynamic and nonlinear effects of SLR on tropical cyclone-induced coastal flooding along a low-gradient coastal landscape (northern Gulf of Mexico [NGOM]). The backbone of the SoS framework is a high-resolution, physics-based, tide, wind-wave, and hurricane storm surge model [Bilskie et al., 2016a] that includes systems of SLR scenarios [Parris et al., 2012], shoreline morphology [Passeri et al., 2016; Plant et al., 2016], marsh evolution [Alizad et al., 2016], and population dynamics driven by carbon emission scenarios [Bilskie et al., 2016b]. Prior to considering future conditions, the storm surge model was comprehensively validated for present-day conditions [Bilskie et al., 2016a]. The present-day model was then modified to represent the potential future landscape based on four SLR scenarios prescribed by Parris et al. [2012] linked to carbon emissions scenarios for the year 2100. Numerical simulations forced by hundreds of synthetic tropical cyclones were performed and the results facilitate the development of return period inundation maps across the NGOM that reflect changes to the coastal landscape. The SoS approach allows new patterns and properties to emerge (i.e. nonlinear and dynamic effects of SLR) that would otherwise be unobserved using a static SLR model.

  4. Rainfall erosivity and rainfall return period in the experimental watershed of Aracruz, in the Coastal Plain of Espirito Santo, Brazil

    USDA-ARS?s Scientific Manuscript database

    The knowledge of the factors influencing water erosion is relevant to land management practices. Rainfall, expressed by rainfall erosivity, is very important among the factors affecting water erosion. Thus, the objective of this study was to determine rainfall erosivity and return period for the Coa...

  5. Joint return periods in hydrology: a critical and practical review focusing on the synthetic design hydrograph estimation

    NASA Astrophysics Data System (ADS)

    Vandenberghe, S.; Graeler, B.; van den Berg, M. J.; Grimaldi, S.; Petroselli, A.; De Baets, B.; Verhoest, N. E. C.

    2012-04-01

    In several branches of engineering the selection of design variables is a common exercise. Recently, there is increasing interest in considering several variables at the same time in the design, which are likely to be associated with each other. In hydrology and hydraulics, applications such as the design of sewer systems or dams, the calculation of flood risks, etc. require the selection of characteristic variables of rainfall or discharge events with a predefined return period. So far, well-established univariate frequency analysis methods have been a standard tool in practice. In contrast, newer methods show a tendency of describing hydrological phenomena with multiple variables. This is challenging practitioners to calculate the multivariate return period and to select a specific design event. In literature, several approaches for the latter problem have evolved over the years, however no study exists on how these methods compare to each other and a controversy on which approach is the right one is going on. In this study, an overview will first be given on the state of the art for defining joint return periods. The construction of multivariate distribution functions will focus on copulas, given their practicality in multivariate frequency analysis. Subsequently, a case study focusing on the selection of design hydrograph characteristics is introduced. In this application, design values of a 3-dimensional phenomenon composed of peak discharge, volume and duration are derived (for given return periods). This case study investigates and compares the different definitions of joint return periods and allows to highlight important issues with respect to multivariate frequency analysis.

  6. It's T time: A study on the return period of multivariate problems

    NASA Astrophysics Data System (ADS)

    Michailidi, Eleni Maria; Balistrocchi, Matteo; Bacchi, Baldassare

    2016-04-01

    One of the most important tasks a hydrologist must face is the proper estimation of the 'design values' of a natural variable corresponding to a given Return Period, T, of failures of the hydraulic 'structure' to be designed or verified. Sometimes the 'structure' is simply the embankments, the failure of which corresponds to the outflows of flood runoff on the surrounding land. The widely adopted definition of T, in a problem regarding the maxima of hydrological variables, is "the average time elapsing between two successive occurrences of an event exceeding a certain magnitude of the natural variables". If T is referred to the minima, the symmetric definition pertains to the "average time between two periods during which the variable ranges below a given magnitude". Conventional (and the only accepted) approaches for estimation of T involve a single natural variable (i.e. flood-peak of a river at a given cross section, the daily maximum discharge, the maximum daily rainfall depth observed at a given rain-gauge). The method of estimation of T entails a frequency analysis of the variable of interest, where the design value of a given T is needed to design the structure of interest (e.g. dams, sewers). In other words, T is used as the index value to set the assigned risk level for the hydraulic works. However, a univariate approach in complex problems ignores the effect of significant variables interrelation leading to different risk levels for each quantity of interest and resulting in a completely wrong estimate of the risk. For example, if one considers the flood inflow in a lake around which cities and villages are positioned, the variable to be investigated in relation to the risk assessment is the lake water level. It is obvious that the same water level may occur from very different flood hydrographs, even when the same initial water level and the same rate curve of outflows are considered. This is a consequence of the interaction of at least three joint

  7. Women in post-trafficking services in Moldova: diagnostic interviews over two time periods to assess returning women's mental health.

    PubMed

    Ostrovschi, Nicolae V; Prince, Martin J; Zimmerman, Cathy; Hotineanu, Mihai A; Gorceag, Lilia T; Gorceag, Viorel I; Flach, Clare; Abas, Melanie A

    2011-04-14

    depression immediately post-return should be offered evidenced-based mental health treatment for at least the standard 12-month period of rehabilitation.

  8. Women in post-trafficking services in moldova: diagnostic interviews over two time periods to assess returning women's mental health

    PubMed Central

    2011-01-01

    -morbid PTSD or other forms of anxiety and depression immediately post-return should be offered evidenced-based mental health treatment for at least the standard 12-month period of rehabilitation. PMID:21492417

  9. Effect of initial conditions and of intra-event rainfall intensity variability on shallow landslide triggering return period

    NASA Astrophysics Data System (ADS)

    Peres, David Johnny; Cancelliere, Antonino

    2016-04-01

    Assessment of shallow landslide hazard is important for appropriate planning of mitigation measures. Generally, return period of slope instability is assumed as a quantitative metric to map landslide triggering hazard on a catchment. The most commonly applied approach to estimate such return period consists in coupling a physically-based landslide triggering model (hydrological and slope stability) with rainfall intensity-duration-frequency (IDF) curves. Among the drawbacks of such an approach, the following assumptions may be mentioned: (1) prefixed initial conditions, with no regard to their probability of occurrence, and (2) constant intensity-hyetographs. In our work we propose the use of a Monte Carlo simulation approach in order to investigate the effects of the two above mentioned assumptions. The approach is based on coupling a physically based hydrological and slope stability model with a stochastic rainfall time series generator. By this methodology a long series of synthetic rainfall data can be generated and given as input to a landslide triggering physically based model, in order to compute the return period of landslide triggering as the mean inter-arrival time of a factor of safety less than one. In particular, we couple the Neyman-Scott rectangular pulses model for hourly rainfall generation and the TRIGRS v.2 unsaturated model for the computation of transient response to individual rainfall events. Initial conditions are computed by a water table recession model that links initial conditions at a given event to the final response at the preceding event, thus taking into account variable inter-arrival time between storms. One-thousand years of synthetic hourly rainfall are generated to estimate return periods up to 100 years. Applications are first carried out to map landslide triggering hazard in the Loco catchment, located in highly landslide-prone area of the Peloritani Mountains, Sicily, Italy. Then a set of additional simulations are performed

  10. Urban flood return period assessment through rainfall-flood response modelling

    NASA Astrophysics Data System (ADS)

    Murla Tuyls, Damian; Thorndahl, Søren

    2017-04-01

    Intense rainfall can often cause severe floods, especially in urbanized areas, where population density or large impermeable areas are found. In this context, floods can generate a direct impact in a social-environmental-economic viewpoint. Traditionally, in design of Urban Drainage Systems (UDS), correlation between return period (RP) of a given rainfall and RP of its consequent flood has been assumed to be linear (e.g. DS/EN752 (2008)). However, this is not always the case. Complex UDS, where diverse hydraulic infrastructures are often found, increase the heterogeneity of system response, which may cause an alteration of the mentioned correlation. Consequently, reliability on future urban planning, design and resilience against floods may be also affected by this misassumption. In this study, an assessment of surface flood RP across rainfall RP has been carried out at Lystrup, a urbanized catchment area of 440ha and 10.400inhab. located in Jutland (Denmark), which has received the impact of several pluvial flooding in the last recent years. A historical rainfall dataset from the last 35 years from two different rain gauges located at 2 and 10 km from the study area has been provided by the Danish Wastewater Pollution Committee and the Danish Meteorological Institute (DMI). The most extreme 25 rainfall events have been selected through a two-step multi-criteria procedure, ensuring an adequate variability of rainfall, from extreme high peak storms with a short duration to moderate rainfall with longer duration. In addition, a coupled 1D/2D surface and network UDS model of the catchment area developed in an integrated MIKE URBAN and MIKE Flood model (DHI 2014), considering both permeable and impermeable areas, in combination with a DTM (2x2m res.) has been used to study and assess in detail flood RP. Results show an ambiguous relation between rainfall RP and flood response. Local flood levels, flood area and volume RP estimates should therefore not be neglected in

  11. From theoretical fixed return period events to real flooding impacts: a new approach to set flooding scenarios, thresholds and alerts

    NASA Astrophysics Data System (ADS)

    Parravicini, Paola; Cislaghi, Matteo; Condemi, Leonardo

    2017-04-01

    ARPA Lombardia is the Environmental Protection Agency of Lombardy, a wide region in the North of Italy. ARPA is in charge of river monitoring either for Civil Protection or water balance purposes. It cooperates with the Civil Protection Agency of Lombardy (RL-PC) in flood forecasting and early warning. The early warning system is based on rainfall and discharge thresholds: when a threshold exceeding is expected, RL-PC disseminates an alert from yellow to red. The conventional threshold evaluation is based on events at a fixed return period. Anyway, the impacts of events with the same return period may be different along the river course due to the specific characteristics of the affected areas. A new approach is introduced. It defines different scenarios, corresponding to different flood impacts. A discharge threshold is then associated to each scenario and the return period of the scenario is computed backwards. Flood scenarios are defined in accordance with National Civil Protection guidelines, which describe the expected flood impact and associate a colour to the scenario from green (no relevant effects) to red (major floods). A range of discharges is associated with each scenario since they cause the same flood impact; the threshold is set as the discharge corresponding to the transition between two scenarios. A wide range of event-based information is used to estimate the thresholds. As first guess, the thresholds are estimated starting from hydraulic model outputs and the people or infrastructures flooded according to the simulations. Eventually the model estimates are validated with real event knowledge: local Civil Protection Emergency Plans usually contain very detailed local impact description at known river levels or discharges, RL-PC collects flooding information notified by the population, newspapers often report flood events on web, data from the river monitoring network provide evaluation of actually happened levels and discharges. The methodology

  12. The return periods and risk assessment of severe dust storms in Inner Mongolia with consideration of the main contributing factors.

    PubMed

    Liu, Xueqin; Li, Ning; Xie, Wei; Wu, Jidong; Zhang, Peng; Ji, Zhonghui

    2012-09-01

    This study presents a methodology for return period analysis and risk assessment of severe dust storm disaster. Meteorological observation data, soil moisture data, and remote sensing data from 30 meteorological stations in Inner Mongolia (western China) from 1985 to 2006 were used for the study. A composite index of severe dust storm disaster (Index I (SDS)) based on the influence mechanisms of the main contributing factors was developed by using the analytic hierarchy process and the weighted comprehensive method, and the hazard risk curves (i.e., the transcendental probability curves of I (SDS)) for the 30 stations were established using the parameter estimation method. We then analyzed the risk of the occurrence of severe dust storm under different scenarios of 5-, 10-, 20-, and 50-year return periods. The results show that the risk decreased from west to east across Inner Mongolia, and there are four severe dust storm occurrence peak value centers, including Guaizihu, Jilantai, Hailisu, and Zhurihe-Erenhot. The severity of dust storms in seven places will be intolerable in the 50-year return period scenario and in three places in the 20-year return period scenario. These results indicate that these locations should concentrate forces on disaster prevention, monitoring, and early warning. The I (SDS) was developed as an easily understandable tool useful for the assessment and comparison of the relative risk of severe dust storm disasters in different areas. The risk assessment was specifically intended to support local and national government agencies in their management of severe dust storm disasters in their efforts to (1) make resource allocation decisions, (2) make high-level planning decisions, and (3) raise public awareness of severe dust storm risk.

  13. Actual 10-year survivors following resection of adrenocortical carcinoma.

    PubMed

    Tran, Thuy B; Postlewait, Lauren M; Maithel, Shishir K; Prescott, Jason D; Wang, Tracy S; Glenn, Jason; Phay, John E; Keplinger, Kara; Fields, Ryan C; Jin, Linda X; Weber, Sharon M; Salem, Ahmed; Sicklick, Jason K; Gad, Shady; Yopp, Adam C; Mansour, John C; Duh, Quan-Yang; Seiser, Natalie; Solorzano, Carmen C; Kiernan, Colleen M; Votanopoulos, Konstantinos I; Levine, Edward A; Hatzaras, Ioannis; Shenoy, Rivfka; Pawlik, Timothy M; Norton, Jeffrey A; Poultsides, George A

    2016-12-01

    Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options beyond surgical resection. The characteristics of actual long-term survivors following surgical resection for ACC have not been previously reported. Patients who underwent resection for ACC at one of 13 academic institutions participating in the US Adrenocortical Carcinoma Group from 1993 to 2014 were analyzed. Patients were stratified into four groups: early mortality (died within 2 years), late mortality (died within 2-5 years), actual 5-year survivor (survived at least 5 years), and actual 10-year survivor (survived at least 10 years). Patients with less than 5 years of follow-up were excluded. Among the 180 patients available for analysis, there were 49 actual 5-year survivors (27%) and 12 actual 10-year survivors (7%). Patients who experienced early mortality had higher rates of cortisol-secreting tumors, nodal metastasis, synchronous distant metastasis, and R1 or R2 resections (all P < 0.05). The need for multi-visceral resection, perioperative blood transfusion, and adjuvant therapy correlated with early mortality. However, nodal involvement, distant metastasis, and R1 resection did not preclude patients from becoming actual 10-year survivors. Ten of twelve actual 10-year survivors were women, and of the seven 10-year survivors who experienced disease recurrence, five had undergone repeat surgery to resect the recurrence. Surgery for ACC can offer a 1 in 4 chance of actual 5-year survival and a 1 in 15 chance of actual 10-year survival. Long-term survival was often achieved with repeat resection for local or distant recurrence, further underscoring the important role of surgery in managing patients with ACC. J. Surg. Oncol. 2016;114:971-976. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. [10 years of liver transplantation in Peru].

    PubMed

    Chaman Ortiz, José Carlos; Padilla Machaca, P Martín; Rondon Leyva, Carlos; Carrasco Mascaró, Felix

    2010-01-01

    The article reviews the experience in 10 years of hepatic transplants performed by The Transplant Department of the National Hospital Guillermo Almenara Irigoyen (HNGAI), describing the history, surgical outcomes in adults and children, retransplantation, combined liver-kidney transplants, complications in 72 transplants performed at the time of submission of the article.

  15. Rheumatoid arthritis: workload and outcome over 10 years.

    PubMed

    Capell, H A; Murphy, E A; Hunter, J A

    1991-06-01

    Rheumatoid arthritis remains a chronic disabling disorder in which medical and surgical intervention may provide amelioration but not cure. In this study a cohort of 123 rheumatoid patients were followed for a period of 10 years from the time of prescription of their initial second-line agent. The workload involved in managing articular, extra-articular and intercurrent disease in these patients has been documented and outcome in relation to continued use of 'disease modifying' therapy evaluated. At 10 years 24 patients (20 per cent) had died and 7 (5 per cent) were not traced; of the 92 (75 per cent) who were assessed, three had become wheelchairbound, two for reasons other than rheumatoid arthritis. Seventy-one per cent of patients required joint surgery, 36 per cent management of peptic ulcer and 45 per cent experienced major episodes of sepsis. Analysis of the results in the 92 patients who were evaluated at 10 years showed significant improvement in Ritchie articular index, pain score, morning stiffness, haemoglobin, platelets, ESR, total globulins, IgG and IgM. Grip strength and Lee functional index showed a trend towards deterioration which did not reach significance. Sixty-seven (73 per cent) of the 92 patients remained on a second- or third-line agent at 10 years (median duration of treatment 107 months); 25 (27 per cent) were not receiving such therapy (median duration of second- and third-line therapy 13 months). The group remaining on treatment showed significant improvement similar to that of the total study group. Those not on treatment improved only for articular index; Lee functional index deteriorated significantly. There was a correlation between area under the curve for ESR over 10 years and radiological progression of disease in hands (r = 0.29, p = 0.026) and in knees and hips (r = 0.3748, p = 0.012) over the 10 year period. Radiographic score correlated well with Lee functional index at the outset and at 10 years and also with the change in

  16. 26 CFR 1.443-1 - Returns for periods of less than 12 months.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... sections 34 and 116 are applicable 750.00 11,250.00 Deductions Real estate taxes 200.00 2 personal....00 Deduct credits: Dividends received for 10-month period $750.00 Less: Excluded portion 50.00...,000 (after credits) 3,348.40 Tax for 10-month period ($3,348.40×10/12) 2,790.33 Example 2. The...

  17. Trading and non-trading period Internet information flow and intraday return volatility

    NASA Astrophysics Data System (ADS)

    Shen, Dehua; Zhang, Wei; Xiong, Xiong; Li, Xiao; Zhang, Yongjie

    2016-06-01

    This paper employs the news appeared in Baidu News as the proxy for Internet information flow, separates them into trading period and non-trading period information and provides alternative evidence for the Mixture of Distribution Hypothesis (MDH). The empirical results show that the contemporary information can effectively reduce the volatility persistence; meanwhile, the lead information and the aggregate information also show some explanatory power. Some future directions are pointed out in the concluding remarks.

  18. Operations, Maintenance, and Replacement 10-Year Plan, 1990 -1999.

    SciTech Connect

    United States. Bonneville Power Administration.

    1990-08-01

    In 1988 Bonneville Power Administration (BPA) began work on this Operations, Maintenance, and Replacement 10-Year Plan to develop a levelized program that would assure high system reliability. During the Programs in Perspective (PIP) meetings in the late summer and fall of 1988, many of the concerns to be addressed in an Operations, Maintenance, and Replacement Plan were identified. Following these PIP meetings BPA established internal work groups. During the winter and spring of 1989, these work groups developed technical background and issue papers on topics that ranged from substation maintenance to environmental protection. In addition, a customer forum group was established and met on several occasions to review work on the plan, to offer ideas and points of view, and to assure that BPA understood customer concerns. Based on recommendations from the work group reports and customer input, BPA's O M Management Team developed the draft Operations, Maintenance, and Replacement 10-Year Plan that was released for public comment during the spring of 1990. During the public review period, BPA received a number of written comments from customers and the interested public. In addition, special meetings were held with interested customers. This final Operations, Maintenance, and Replacement 10-Year Plan reflects BPA's response to customers and interested public on each topic discussed in the 10-Year Plan. The plan is a distillation of BPA's strategies to achieve a levelized program over 10 years.

  19. Operations, Maintenance, and Replacement 10-Year Plan, 1990--1999

    SciTech Connect

    Not Available

    1990-08-01

    In 1988 Bonneville Power Administration (BPA) began work on this Operations, Maintenance, and Replacement 10-Year Plan to develop a levelized program that would assure high system reliability. During the Programs in Perspective (PIP) meetings in the later summer and fall of 1988, many of the concerns to be addressed in an Operations, Maintenance, and Replacement Plan were identified. Following these PIP meetings BPA established internal work groups. During the winter and spring of 1989, these work groups developed technical background and issue papers on topics that ranged from substation maintenance to environmental protection. In addition, a customer forum group was established and met on several occasions to review work on the plan, to offer ideas and points of view, and to assure that BPA understood customer concerns. Based on recommendations from the work group reports and customer input, BPA's O M Management Team developed the draft Operations, Maintenance, and Replacement 10-Year Plan that was released for public comment during the spring of 1990. During the public review period, BPA received a number of written comments from customers and the interested public. In addition, special meetings were held with interested customers. This final Operations, Maintenance, and Replacement 10-year Plan reflects BPA's response to customers and interested public on each topic discussed in the 10-Year Plan. The plan is a distillation of BPA's strategies to achieve a levelized program over 10 years.

  20. AMS at ANTARES - The first 10 years

    NASA Astrophysics Data System (ADS)

    Lawson, E. M.; Elliott, G.; Fallon, J.; Fink, D.; Hotchkis, M. A. C.; Hua, Q.; Jacobsen, G. E.; Lee, P.; Smith, A. M.; Tuniz, C.; Zoppi, U.

    2000-10-01

    The status and capabilities of the ANTARES AMS facility after 10 years are reviewed. The common AMS radioisotopes, 10Be, 14C, 26Al, 36Cl and 129I, are routinely analysed. A capability for the detection of 236U and other actinide isotopes has been developed. The measurement program includes support to Quaternary science projects at Australian universities and to ANSTO projects in global climate change and nuclear safeguards.

  1. Neurology--the next 10 years.

    PubMed

    Baron, Ralf; Ferriero, Donna M; Frisoni, Giovanni B; Bettegowda, Chetan; Gokaslan, Ziya L; Kessler, John A; Vezzani, Annamaria; Waxman, Stephen G; Jarius, Sven; Wildemann, Brigitte; Weller, Michael

    2015-11-01

    Since the launch of our journal as Nature Clinical Practice Neurology in 2005, we have seen remarkable progress in many areas of neurology research, but what does the future hold? Will advances in basic research be translated into effective disease-modifying therapies, and will personalized medicine finally become a reality? For this special Viewpoint article, we invited a panel of Advisory Board members and other journal contributors to outline their research priorities and predictions in neurology for the next 10 years.

  2. Assessment of possible changes in return period and ranking of losses associated with European wind storms in a future climate

    NASA Astrophysics Data System (ADS)

    Karremann, M. K.; Pinto, J. G.; Klawa, M.; Della-Marta, P. M.; Stowasser, M.

    2010-09-01

    Winter storms are one of the major natural hazards affecting Europe. Possible changes in return periods and ranking of European wind storms in a future climate are investigated based on transient GCM simulations. The intensity of a storm is quantified by the associated estimated loss, which is derived using the storm loss model originally developed by Klawa and Ulbrich (2003), here adapted to estimate losses for individual storms. Daily maximum wind speeds are used to compute the estimated loss for each storm considering exceedences of the local 98th wind percentile. If a storm affects Europe during more than one day, the largest daily loss is considered. The total estimated loss for a single storm is then given by the sum estimated loss values for all grid points affected by the storm. We focus our investigation on Western and Central Europe, particularly in the "core Europe" countries (Germany, France, Netherlands, Belgium, Denmark, United Kingdom and Ireland). The method is first tested for wind storm losses based on ERA40 data. Results reveal that the method is able to estimate well the spatial extension and ranking of losses associated with historical storms. We use robust Extreme Value Analysis (EVA) techniques which fit an extreme value distribution to data above a high threshold to estimate the return periods of storm losses. In order to estimate possible changes in return periods and rankings of storm loss in a future climate, GCM data for recent (20C, 1960-2000) and future climate conditions (SRES A1B and A2, 2001-2100) is considered. Results show that both the number and intensity of extreme losses increases under future climate conditions. There is a strong shift of storm loss rankings, with a present day top 1 becoming a rank 6 (A1B) or rank 8 (A2) event. In particular, we found storms with estimated losses exceeding almost two times the largest events identified for the 20th century. Accordingly, a significant shortening of return periods of European

  3. Return to 1990: The cost of mitigating United States carbon emissions in the post-2000 period

    SciTech Connect

    Edmonds, J.A.; Kim, S.H.; MacCracken, C.N.; Sands, R.D.; Wise, M.A.

    1997-10-01

    The Second Generation Model (SGM) is employed to examine four hypothetical agreements to reduce emissions in Annex 1 nations (OECD nations plus most of the nations of Eastern Europe and the former Soviet Union) to levels in the neighborhood of those which existed in 1990, with obligations taking effect in the year 2010. The authors estimate the cost to the US of complying with such agreements under three distinct conditions: no trading of emissions rights, trading of emissions rights only among Annex 1 nations, and a fully global trading regime. The authors find that the marginal cost of returning to 1990 emissions levels in the US in the absence of trading opportunities is approximately $108 per metric ton carbon in 2010. The total cost in that year is approximately 0.2% of GDP. International trade in emissions permits lowers the cost of achieving any mitigation objective by equalizing the marginal cost of carbon mitigation among countries. For the four mitigation scenarios in this study, economic costs to the US remain below 1% of GDP through at least the year 2020.

  4. Should age-period-cohort studies return to the methodologies of the 1970s?

    PubMed

    Reither, Eric N; Masters, Ryan K; Yang, Yang Claire; Powers, Daniel A; Zheng, Hui; Land, Kenneth C

    2015-03-01

    Social scientists have recognized the importance of age-period-cohort (APC) models for half a century, but have spent much of this time mired in debates about the feasibility of APC methods. Recently, a new class of APC methods based on modern statistical knowledge has emerged, offering potential solutions. In 2009, Reither, Hauser and Yang used one of these new methods - hierarchical APC (HAPC) modeling - to study how birth cohorts may have contributed to the U.S. obesity epidemic. They found that recent birth cohorts experience higher odds of obesity than their predecessors, but that ubiquitous period-based changes are primarily responsible for the rising prevalence of obesity. Although these findings have been replicated elsewhere, recent commentaries by Bell and Jones call them into question - along with the new class of APC methods. Specifically, Bell and Jones claim that new APC methods do not adequately address model identification and suggest that "solid theory" is often sufficient to remove one of the three temporal dimensions from empirical consideration. They also present a series of simulation models that purportedly show how the HAPC models estimated by Reither et al. (2009) could have produced misleading results. However, these simulation models rest on assumptions that there were no period effects, and associations between period and cohort variables and the outcome were perfectly linear. Those are conditions under which APC models should never be used. Under more tenable assumptions, our own simulations show that HAPC methods perform well, both in recovering the main findings presented by Reither et al. (2009) and the results reported by Bell and Jones. We also respond to critiques about model identification and theoretically-imposed constraints, finding little pragmatic support for such arguments. We conclude by encouraging social scientists to move beyond the debates of the 1970s and toward a deeper appreciation for modern APC methodologies

  5. Should Age-Period-Cohort Studies Return to the Methodologies of the 1970s?

    PubMed Central

    Masters, Ryan K.; Yang, Y. Claire; Powers, Daniel A.; Zheng, Hui; Land, Kenneth C.

    2015-01-01

    Social scientists have recognized the importance of age-period-cohort (APC) models for half a century, but have spent much of this time mired in debates about the feasibility of APC methods. Recently, a new class of APC methods based on modern statistical knowledge has emerged, offering potential solutions. In 2009, Reither, Hauser and Yang used one of these new methods – hierarchical APC (HAPC) modeling – to study how birth cohorts may have contributed to the U.S. obesity epidemic. They found that recent birth cohorts experience higher odds of obesity than their predecessors, but that ubiquitous period-based changes are primarily responsible for the rising prevalence of obesity. Although these findings have been replicated elsewhere, recent commentaries by Bell and Jones call them into question – along with the new class of APC methods. Specifically, Bell and Jones claim that new APC methods do not adequately address model identification and suggest that “solid theory” is often sufficient to remove one of the three temporal dimensions from empirical consideration. They also present a series of simulation models that purportedly show how the HAPC models estimated by Reither et al. (2009) could have produced misleading results. However, these simulation models rest on assumptions that there were no period effects, and associations between period and cohort variables and the outcome were perfectly linear. Those are conditions under which APC models should never be used. Under more tenable assumptions, our own simulations show that HAPC methods perform well, both in recovering the main findings presented by Reither et al. (2009) and the results reported by Bell and Jones. We also respond to critiques about model identification and theoretically-imposed constraints, finding little pragmatic support for such arguments. We conclude by encouraging social scientists to move beyond the debates of the 1970s and toward a deeper appreciation for modern APC

  6. Photovoltaics - 10 years after Cherry Hill

    NASA Astrophysics Data System (ADS)

    Ralph, E. L.

    The status of R&D programs connected with photovoltaic (PV) systems 10 years after the Cherry Hill workshop on 'Photovoltaic Conversion of Solar Energy for Terrestrial Applications' is assessed. The five categories of research recommended by the Cherry Hill Workshop are listed in a table together with their recommended research budget allocations. The workshop categories include: single-crystal Si cells; poly-Si cells; systems and diagnostics. Categories for thin film CdS/Cu2S and CuInSe2 cells are also included. The roles of government and private utility companies in providing adequate financial support for PV research programs is emphasized.

  7. Mitochondrial ROS Metabolism: 10 Years Later

    PubMed Central

    Kushnareva, Y. E.; Murphy, A. N.

    2015-01-01

    The role of mitochondria in oxidative stress is well recognized, but many questions are still to be answered. This article is intended to update our comprehensive review in 2005 by highlighting the progress in understanding of mitochondrial reactive oxygen species (ROS) metabolism over the past 10 years. We review the recently identified or re-appraised sources of ROS generation in mitochondria, such as p66shc protein, succinate dehydrogenase, and recently discovered properties of the mitochondrial antioxidant system. We also reflect upon some controversies, disputes, and misconceptions that confound the field. PMID:26071769

  8. Mitochondrial ROS Metabolism: 10 Years Later.

    PubMed

    Andreyev, A Y; Kushnareva, Y E; Murphy, A N; Starkov, A A

    2015-05-01

    The role of mitochondria in oxidative stress is well recognized, but many questions are still to be answered. This article is intended to update our comprehensive review in 2005 by highlighting the progress in understanding of mitochondrial reactive oxygen species (ROS) metabolism over the past 10 years. We review the recently identified or re-appraised sources of ROS generation in mitochondria, such as p66(shc) protein, succinate dehydrogenase, and recently discovered properties of the mitochondrial antioxidant system. We also reflect upon some controversies, disputes, and misconceptions that confound the field.

  9. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... property other than stock in trade; (C) Sales and purchases of patents, inventions, models, or designs... make one return. Such joint return shall be filed with the income tax return of any one of the persons making such joint return. (2) Persons excepted from furnishing information—(i) Conditions. Any...

  10. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... tangible property other than stock in trade; (C) Sales and purchases of patents, inventions, models, or... make one return. Such joint return shall be filed with the income tax return of any one of the persons making such joint return. (2) Persons excepted from furnishing information—(i) Conditions. Any...

  11. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... property other than stock in trade; (C) Sales and purchases of patents, inventions, models, or designs... make one return. Such joint return shall be filed with the income tax return of any one of the persons making such joint return. (2) Persons excepted from furnishing information—(i) Conditions. Any...

  12. Aqua's First 10 Years: An Overview

    NASA Technical Reports Server (NTRS)

    Parkinson, Claire L.

    2012-01-01

    NASA's Aqua spacecraft was launched at 2:55 a.m. on May 4, 2002, from Vandenberg Air Force Base in California, into a near-polar, sun-synchronous orbit at an altitude of 705 km. Aqua carries six Earth-observing instruments to collect data on water in all its forms (liquid, vapor, and solid) and on a wide variety of additional Earth system variables (Parkinson 2003). The design lifetime for Aqua's prime mission was 6 years, and Aqua is now well into its extended mission, approaching 10 years of successful operations. The Aqua data have been used for hundreds of scientific studies and continue to be used for scientific discovery and numerous practical applications.

  13. Perceived Partner Responsiveness Predicts Diurnal Cortisol Profiles 10 Years Later

    PubMed Central

    Slatcher, Richard B.; Selcuk, Emre; Ong, Anthony D.

    2015-01-01

    Several decades of research have demonstrated that marital relationships have a powerful influence on physical health. However, surprisingly little is known about how marriage affects health—both in terms of psychological processes and biological ones. We investigated the associations between perceived partner responsiveness—the extent to which people feel understood, cared for and appreciated by their romantic partner—and diurnal cortisol over a 10-year period in a large sample of married and cohabitating couples in the U.S. Partner responsiveness predicted higher wakeup cortisol values and steeper (“healthier”) cortisol slopes at the 10-year follow-up, and these associations remained strong after controlling for demographic factors, depressive symptoms, agreeableness, and other positive and negative relationship factors. Further, declines in negative affect over the 10-year period mediated the prospective association between responsiveness and cortisol slope. These findings suggest that diurnal cortisol may be a key biological pathway through which social relationships impact long-term health. PMID:26015413

  14. Optogenetics: 10 years of microbial opsins in neuroscience

    PubMed Central

    Deisseroth, Karl

    2016-01-01

    Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies for guiding light through tissue have enabled versatile optical control of defined cells in living systems, defining modern optogenetics. Despite widespread recognition of the importance of spatiotemporally precise causal control over cellular signaling, for nearly the first half (2005–2009) of this 10-year period, as optogenetics was being created, there were difficulties in implementation, few publications and limited biological findings. In contrast, the ensuing years have witnessed a substantial acceleration in the application domain, with the publication of thousands of discoveries and insights into the function of nervous systems and beyond. This Historical Commentary reflects on the scientific landscape of this decade-long transition. PMID:26308982

  15. Optogenetics: 10 years of microbial opsins in neuroscience.

    PubMed

    Deisseroth, Karl

    2015-09-01

    Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies for guiding light through tissue have enabled versatile optical control of defined cells in living systems, defining modern optogenetics. Despite widespread recognition of the importance of spatiotemporally precise causal control over cellular signaling, for nearly the first half (2005-2009) of this 10-year period, as optogenetics was being created, there were difficulties in implementation, few publications and limited biological findings. In contrast, the ensuing years have witnessed a substantial acceleration in the application domain, with the publication of thousands of discoveries and insights into the function of nervous systems and beyond. This Historical Commentary reflects on the scientific landscape of this decade-long transition.

  16. 10-year evapotranspiration estimates in a Bornean tropical rainforest

    NASA Astrophysics Data System (ADS)

    Kume, T.; Tanaka, N.; Komatsu, H.; Yoshifuji, N.; Saitoh, T. M.; Suzuki, M.; Kumagai, T.

    2010-12-01

    This study was undertaken to quantify 10-year evapotranspiration (ET) in a tropical rainforest, Sarawak, Malaysia. To this aim, a simplified big-leaf model was formulated, which can consider transpiration (Et) and rainfall interception (Ei). The model was independently validated using eddy covariance fluxes, rainfall interception based on throughfall and stemflow measurements, and sap flow measurements conducted for more than two years. Consequently, our big-leaf model could successfully reproduce Et and Ei. By using the model and a 10-year meteorological data set, Et, Ei, and ET was estimated in the period between 2000 and 2009. The annual Et , Ei, and ET averaged over 10 years were estimated as 1114, 209, and 1323 mm, respectively, with the small seasonal fluctuations. The derived estimations for 10 years showed conservative year-to-year variations in Et, Ei, and ET (CV = 5-7%) against considerable year-to-year variations in annual rainfall (CV = 11%). Specific rainfall characteristics in this site could be a reason for conservative year-to-year variations in Ei. Small interannual variations in meteorological conditions and no occurrence of unusually severe drought in this study period could be a reason for the small year-to-year variations in Et. As well, we compared ET, Ei at this site with those of other tropical forests. Our forest ET was smaller than global maximum value of ET estimated in other tropical forests because of the smaller Ei, relative to annual rainfall at this site. Based on the derived characteristics of ET, we also discussed possible changes in ET, Et, and Ei in response to changes in rainfall regime at this site.

  17. nutritionDay: 10 years of growth.

    PubMed

    Schindler, Karin; Pichard, Claude; Sulz, Isabella; Volkert, Dorothee; Streicher, Melanie; Singer, Pierre; Ljungqvist, Olle; Van Gossum, Andre; Bauer, Peter; Hiesmayr, Michael

    2017-10-01

    Despite high prevalence at hospital admission, disease related malnutrition (DRM) remains under recognized and undertreated. DRM is associated with increased morbidity, hospital readmission rate, and burden for the healthcare system. The compelling need to increase awareness and knowledge through an international survey has triggered the launch of the nutritionDay (ND) concept. ND is a worldwide annual systematic collection and analysis of data in hospital wards, intensive care units and nursing homes. ND is based on questionnaires to systematically collect and analyze the patient's characteristics, food intake and nutrition support, as well as the determinants of their environment (facility, health care personal, etc …). Questionnaires, outcome documentation sheets and step-by-step guidance are available as download in 30 languages. ND has described the nutritional status and behavior of over 150,000 hospitalized patients and nursing home's patients in over 56 participating countries. These data allowed a local, regional, national and international benchmarking at different levels (i.e. type of medical pathologies, care facilities, etc.) and over time. Sixteen peer-reviewed publications have already been released and picture the international scene of DRM. This review presents the 10-year of the ND project development and shows how ND serves all health care professionals to optimize nutrition care and nutrition related structures. ND keeps progressing and is likely to become a standard tool for determining the nutritional status and behavior of hospitalized patients and nursing home's population. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  18. A system for generating long streamflow records for study of floods of long return period: Phase 2

    SciTech Connect

    Franz, D.D.; Kraeger, B.A.; Linsley, R.K.

    1989-02-01

    Knowledge of the return periods of large floods is required to make risk analyses for nuclear power plants subject to flooding from rivers. The system reported here combined the stochastic simulation of hourly rainfall data and daily pan evaporation data with the deterministic simulation of streamflow by using the synthetic rainfall and evaporation data as input to a calibrated rainfall runoff model. The sequence of annual maximum flood peaks from a synthetic record of 10,000 years or more was then analyzed to obtain estimates of flood frequency. The reasonableness of the flood frequency results must be evaluated on the degree of mimicry of the key characteristics of the observed rainfall data and the ability of the rainfall-runoff model to mimic the observed flood frequency during the calibration period. On this basis, the flood frequency results appeared to be a reasonable extrapolation of the data used in defining the model parameters. There is a need to develop regional parameters for the stochastic models and to conduct research on the relationship between the stochastic structure of rainfall and stochastic structure of flood frequency. The methodology is applicable, assuming a highly skilled analyst, to watersheds similar to those already tested.

  19. Etiology of stillbirth at term: a 10-year cohort study.

    PubMed

    Walsh, Colin A; Vallerie, Amy M; Baxi, Laxmi V

    2008-07-01

    To examine etiological factors contributing to cases of intrauterine fetal demise in term pregnancies over a 10-year period. This was a retrospective cohort analysis of 29 908 term (37(+0) to 41(+6) weeks gestation) infants delivering in a single tertiary-referral university institution over the 10-year period from 1996 to 2005. Cases of stillbirth were identified from a computerized hospital database, and pathological, clinical, and biochemical data were reviewed for all cases. Trends were analyzed using the Cusick test for trend. Categorical data were analyzed using the Fisher's exact test, with the 5% level considered significant. The incidence of intrauterine fetal demise at term was 1.8 per 1000 at-risk pregnancies. There was no significant downward trend in the rate of term stillbirth between 1996 and 2005 (p = 0.0808). Stillbirths were unexplained in 51% of cases, although in many cases a possible etiological factor was identified but not necessarily proven. There was a significant downward trend in the incidence of unexplained term stillbirths at our institution over the 10-year study period (p = 0.0105). Placental/cord factors accounted for 25% of term stillbirths and did not decrease significantly over the study period (p = 0.0953). Almost 50% of term stillbirths occurred in women who registered late or had no antenatal care. However, suboptimal antenatal care was not predictive of differences in either acceptance of perinatal postmortem or successful identification of stillbirth etiology. The incidence of stillbirth at term is 2 per 1000 term pregnancies and has not changed significantly in the past 10 years. Almost 50% of term stillbirths occurred in women with suboptimal antenatal care. More than half of cases are unexplained, often resulting from an incomplete diagnostic work-up. Despite this, there has been a significant downward trend in the rates of unexplained stillbirth at term. It is imperative that a complete diagnostic work-up is performed in

  20. Administrative Reinstatement Interlock Programs: Florida, a 10-Year Study

    PubMed Central

    Voas, Robert B.; Tippetts, A. Scott; Grosz, Milton

    2013-01-01

    Background Interlocks reduce driving-under-the-influence (DUI) recidivism by 64%, but offenders resist installing them, preferring to risk driving while their driver’s licenses are revoked. One method of motivating offenders to install an interlock is require it for reinstatement of their driver’s license. This report updates an earlier evaluation of the administrative reinstatement interlock program (ARIP) procedure implemented in Florida in 2002. Method Driver records and interlock program records covering 120,000 DUI offenders were followed over 10 years. The flow through the sanction system—conviction, reinstatement, interlock program, and postinterlock period—is described. Logistical regression was used to identify the characteristics of offenders who installed interlocks, and survival analysis was used to evaluate the recidivism of offenders in the various stages in the ARIP. Results At any given time, approximately one third of the convicted offenders were serving their license-revocation periods. Half of the offenders who completed their revocation periods remain unqualified for reinstatement because they do not fulfill other requirements. ARIP offenders who do qualify for reinstatement and install interlocks have lower recidivism rates while the devices are on their vehicles. Conclusions After 10 years, Florida’s ARIP is a mature system that succeeds in forcing all offenders in the program who qualify for reinstatement to install an interlock for at least 6 months. However, half of all offenders who complete their mandatory revocation period are either unable to, or choose not to, qualify for reinstatement. PMID:23442206

  1. 10 Year Publication Trends in Dermatology in Mainland China

    PubMed Central

    Xin, Shujun; Mauro, Jacqueline A; Mauro, Theodora M; Elias, Peter M; Man, Mao-Qiang

    2013-01-01

    Background China has been experiencing huge changes in all aspects including dermatologic research since its reform in 1978. However, how the economic and intellectual development has influenced the publication trends in the field of dermatology, which could mirror the scientific development in other medical disciplines, is unknown. In the present study, we analyzed the publication trends from departments of dermatology in mainland China from 2002 to 2011. Materials and Methods All publication data were obtained from www.pubmed.com. Only papers published from dermatology departments of mainland China were used for analysis. Results The number of publications increased 10-fold over this 10 year period. A total 1,231 of articles were published in English in 251 journals between 2002 and 2011. A total of 129 journals published only one paper from dermatology departments of mainland China. Over 60% of articles were original research and 21.7% were case reports. Among these 251 journals, foremost was the Journal of Clinical Experimental Dermatology, which published 5.9% of all papers from mainland China. 2.7% papers were published in the Journal of Investigative Dermatology. The number of publications positively correlated with the changes in gross domestic product per capita during the study period. Conclusions These results suggest that the number of publications in the dermatology field has increased markedly in mainland China over the last 10 years. This dramatic increase in publications could be, at least partially, attributed to the significant improvement in economic conditions in mainland China. PMID:23968296

  2. Chronic pain in multiple sclerosis: A 10-year longitudinal study.

    PubMed

    Young, Jamie; Amatya, Bhasker; Galea, Mary P; Khan, Fary

    2017-07-01

    Pain is a common symptom associated with multiple sclerosis (MS), and has lasting effects on an individual's functional capacity and quality of life. A wide range of prevalence rates of pain (between 23% and 90%)have been reported in MS and this is mainly due to the methodological differences amongst the studies such as variability in patient sources, method of sampling and the definition of pain used. Chronic pain in MS, defined as pain lasting for greater than 3-6 months, can have a significant impact on their biopsychosocial health, including negative impact on activities of daily living, relationships and social participation. The long-term course of MS-related pain and its impact in an Australian cohort over a 7-year period has been investigated earlier. The aim of this longitudinal study was to describe the impact of chronic pain, pain-related disability and carer burden in persons with MS over a 10-year period. The aim of this longitudinal study was to describe the impact of chronic pain, pain-related disability and carer burden in persons with MS over a 10-year period. This was a prospective longitudinal study conducted at the Rehabilitation Department of Royal Melbourne Hospital (RMH), a tertiary referral hospital in Victoria and Australia. The source of participants was from the RMH MS database and contains detailed MS patient information including demographic data, diagnosis details (using McDonald's criteria), pain characteristics. Structured face-face interviews and validated measures were used, which include the visual analogue scale (VAS); chronic pain grade (CPG); the assessment of quality of life (AQoL) and the carer strain index (CSI). The mean age of the participants (n=70) was 55.3 years and majority (70%) were female. The mean age of the participants (n=70) was 55.3 years and majority (70%) were female. The findings show that over time (10 years), participants report having greater bilateral bodily pain and greater description of pain as 'worse

  3. Origin and dynamics of suspended sediment during a 10-yr return period flood on the Bès River, Southern French Alps

    NASA Astrophysics Data System (ADS)

    Evrard, O.; Navratil, O.; Esteves, M.; Legout, C.; Ayrault, S.; Némery, J.; Lefèvre, I.; Bonté, P.; Tacon, S.; Liébault, F.

    2011-12-01

    In mountains, an excessive sediment supply to the rivers typically leads to an increase in water turbidity and a rapid filling of reservoirs in downstream areas. This situation is particularly problematic in regions where reservoirs are used to provide drinking water to large cities or clear water to hydroelectric power plants (e.g., in the French Southern Alps). Sediment source areas must first be delineated and sediment fluxes between hillslopes and the river system must be better understood to implement efficient sediment management. In this context, the Sediment Transport and Erosion Across MountainS STREAMS project (2007-2010) funded by the French National Research Agency (ANR) aimed at understanding the spatial and temporal dynamics of fine sediment at the scale of two mountainous watersheds located in contrasted environments (range, 10 - 1,000 km2). One of the main specificities of this project consisted in combining traditional monitoring techniques and sediment fingerprinting using elemental geochemistry (determined using Instrumental Neutron Activation Analysis - INAA, and Inductively Coupled Plasma - Mass Spectrometry - ICP-MS) and fallout radionuclides (measured by gamma spectrometry) as potential discriminant properties. The combination of both these approaches provided valuable information on the temporal variability of suspended sediment sources and sediment transfer within the river network. This presentation will focus on the results obtained during a 10-years return period flood that occurred on the Bès River (165 km2), the main tributary of the Bléone River (905 km2), Southern French Alps. Suspended sediment concentrations and yields were estimated using discharge and turbidity monitoring (records with 10 min. time step) and sediment sampling during the flood. Rainfall intensity, volume, distribution and nature were estimated using 3 rain gauges and rainfall radar images. Sediment fingerprinting was conducted using a mixing model based on

  4. Natural History of Thyroid Function in Adults with Down Syndrome--10-Year Follow-Up Study

    ERIC Educational Resources Information Center

    Prasher, V.; Gomez, G.

    2007-01-01

    Background: The natural history of thyroid function in adults with Down syndrome (DS) is unknown. Method: This study investigated annual thyroid function tests in 200 adults with DS over a 10-year period. Results: Transient and persistent thyroid dysfunction was common. The 5- and 10-year incidence of definite hypothyroidism was 0.9%-1.64% and…

  5. Natural History of Thyroid Function in Adults with Down Syndrome--10-Year Follow-Up Study

    ERIC Educational Resources Information Center

    Prasher, V.; Gomez, G.

    2007-01-01

    Background: The natural history of thyroid function in adults with Down syndrome (DS) is unknown. Method: This study investigated annual thyroid function tests in 200 adults with DS over a 10-year period. Results: Transient and persistent thyroid dysfunction was common. The 5- and 10-year incidence of definite hypothyroidism was 0.9%-1.64% and…

  6. Revegetation after strip cutting and block clearcutting in northern hardwoods: a 10-year history

    Treesearch

    C. Wayne Martin; Hornbeck James W.; Hornbeck James W.

    1989-01-01

    Changes in the density and biomass of trees, shrubs, and herbs were measured periodically over 10 years following a progressive strip cutting and block clearcutting of northern hardwoods. At 10 years after clearcutting, yellow birch was the most numerous commercial or uncommercial tree on the block clearcut; sugar maple on the strip cut. Pin cherry dominated the...

  7. Interlaminar discectomy in lumbar disc herniation: shorten postoperative return to work period in recruits undergoing military training.

    PubMed

    Celik, Haydar; Derincek, Alihan; Arslanoglu, Atilla

    2008-09-01

    The operative treatment of lumbar disc disease has long challenged spine surgeons. In this study, we aimed to show that recruits with lumbar disc herniation managed by the interlaminar approach could return to work after 6 weeks. Forty male recruits were included in this study and interlaminar discectomy was adequate in 40 cases. Early postoperative rehabilitation had a positive effect on early return to work. We believe that interlaminar lumbar discectomy is an effective technique for treating patients with herniated lumbar discs; with early postoperative rehabilitation, recruits can return to work 6 weeks after surgery.

  8. Depression and vulnerability to incident physical illness across 10 years.

    PubMed

    Holahan, Charles J; Pahl, Sandra A; Cronkite, Ruth C; Holahan, Carole K; North, Rebecca J; Moos, Rudolf H

    2010-06-01

    While considerable research exists on the role of physical illness in initiating depressive reactions, the role of depression in the onset of physical illness is much less studied. Moreover, whereas almost all previous research on depression and incident physical illness has involved specific physical illnesses, the present study examines the link between depression and incident physical illness more generally. The study followed 388 clinically depressed patients who were entering treatment for unipolar depressive disorders and 404 matched community controls across 10 years. In self-report surveys, sociodemographic and health behavior data were indexed at baseline and physician-diagnosed medical conditions were indexed at baseline and at 1, 4, and 10 years during the follow-up period. After accounting for prior physical illness and key demographic and health behavior factors, membership in the depressed group was significantly linked to physical illness during the follow-up period. In these prospective analyses, depressed patients showed an almost two-thirds higher likelihood of experiencing physical illness during the follow-up period compared to community controls. The prospective association between depression and subsequent physical illness was evident for both less serious and more serious physical illness. Although participants were asked to report only physician-diagnosed conditions, the association between depression and physical illness may have been due to depressed individuals perceiving themselves as more ill than they were. The World Health Organization has included the co-morbidity between depression and chronic physical illness among its ten concerns in global public health. The current findings broaden the growing awareness of the co-morbidity between depression and physical illness to encompass a vulnerability of depressed individuals to physical illness more generally. Copyright 2009 Elsevier B.V. All rights reserved.

  9. Draft 1992 : Operations, Maintenance, and Replacement 10-Year Plan.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-05-01

    Two years ago, BPA released its first-ever Operations, Maintenance, and Replacement (OM&R) 10-Year Plan. That effort broke new ground and was an extensive look at the condition of Operations, Maintenance, and Replacement on BPA`s power system. This document -- the 1992 OM&R 10-Year Plan -- uses that original plan as its foundation. It takes a look at how well BPA has accomplished the challenging task set out in the 1990 Plan. The 1992 Plan also introduces the Construction Program. Construction`s critical role in these programs is explored, and the pressures of construction workload -- such as the seasonal nature of the work and the broad swings in workload between projects and years -- are discussed. The document then looks at how situations may have changed with issues explored initially in the 1990 Plan. Importantly, this Plan also surfaces and explains some new issues that threaten to impact BPA`s ability to accomplish its OM&R workload. Finally, the document focuses on the revised strategies for Operations, Maintenance, Replacement, Construction, and Environment for the 1992 to 2001 time period, including the financial and human resources needed to accomplish those strategies.

  10. Draft 1992 : Operations, Maintenance, and Replacement 10-Year Plan.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-05-01

    Two years ago, BPA released its first-ever Operations, Maintenance, and Replacement (OM R) 10-Year Plan. That effort broke new ground and was an extensive look at the condition of Operations, Maintenance, and Replacement on BPA's power system. This document -- the 1992 OM R 10-Year Plan -- uses that original plan as its foundation. It takes a look at how well BPA has accomplished the challenging task set out in the 1990 Plan. The 1992 Plan also introduces the Construction Program. Construction's critical role in these programs is explored, and the pressures of construction workload -- such as the seasonal nature of the work and the broad swings in workload between projects and years -- are discussed. The document then looks at how situations may have changed with issues explored initially in the 1990 Plan. Importantly, this Plan also surfaces and explains some new issues that threaten to impact BPA's ability to accomplish its OM R workload. Finally, the document focuses on the revised strategies for Operations, Maintenance, Replacement, Construction, and Environment for the 1992 to 2001 time period, including the financial and human resources needed to accomplish those strategies.

  11. Mumps Cases Hit 10-Year High in U.S.

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_162676.html Mumps Cases Hit 10-Year High in U.S. Contagious ... 21, 2016 WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- Mumps cases have hit a 10-year high in ...

  12. Scurvy in a 10-year-old boy.

    PubMed

    Cole, John A; Warthan, Molly M; Hirano, Stefanie A; Gowen, Clarence W; Williams, Judith V

    2011-01-01

    Scurvy, or hypovitaminosis C, is an uncommon condition that exists today primarily within certain unique populations-particularly the elderly subjects, patients with neurodevelopmental disabilities or psychiatric illnesses, or others with unusual dietary habits. Vitamin C is an essential nutrient in the human body, and is important in synthesizing collagen factor whose faulty production is responsible for most of the clinical manifestations of scurvy. These clinical manifestations can include dystrophic or corkscrew hairs, gingival hyperplasia, and weakened blood vessel walls, causing bleeding in the skin, joints, and other organs. Although rare in the Unites States, the presence of scurvy should not be forgotten because of its presence among susceptible populations. Moreover, with its diagnosis, treatment and cure is one of the simplest in modern medicine. We report a case of scurvy in a 10-year-old autistic child. © 2010 Wiley Periodicals, Inc.

  13. [One-stop outpatient cardiology clinics: 10 years' experience].

    PubMed

    Falces, Carlos; Sadurní, Josep; Monell, Joan; Andrea, Rut; Ylla, Miquel; Moleiro, Angels; Cantillo, Jordi

    2008-05-01

    A one-stop outpatient cardiology clinic was set up at the Vic General Hospital in Spain in 1996. The aims were to provide patients with a rapid response, and to ensure that, on the same day, they saw a specialist and were referred for any relevant investigations required, primarily echocardiography, exercise testing, and Holter monitoring. We report experience from 10 years of follow-up, involving 19,515 consultations. The mean waiting time for a consultation was 3 days. We analyzed the reasons for the consultations, the investigations carried out, and the reductions in follow-up visits and hospital admissions. Primary care physicians' level of satisfaction was increased by this approach. The one-stop clinic proved feasible in clinical practice and proved robust during the follow-up period. This clinical model was beneficial for patients, was highly acceptable to primary care physicians, reduced the need for patients to contact the hospital, and, possibly, reduced hospital admissions.

  14. Dynamics of income packaging: a 10-year longitudinal study.

    PubMed

    Zippay, Allison

    2002-07-01

    This article examines the methods and dynamics of packaging multiple sources of wage and nonwage income as a means of making ends meet over a 10-year period among a sample of displaced steelworkers who lost jobs as a result of plant closings in the 1980s and then experienced extensive downward mobility. The study tracked changes in the respondents' income and employment over a decade, the dynamics of their use of social services, their pooling of a variety of income sources, and the use of social assistance to supplement low wages. The study found that among this sample income packaging was a universal economic strategy and that use of social services did not affect later employment and earnings.

  15. On the effect of the sampling frequency of sea level measurements on return period estimate of extremes—Southern European examples

    NASA Astrophysics Data System (ADS)

    Tsimplis, M. N.; Marcos, M.; Pérez, B.; Challenor, P.; Garcia-Fernandez, M. J.; Raicich, F.

    2009-10-01

    Estimates of extreme sea levels and return periods have been based mainly on hourly sampling rates. Technological development has enabled the sampling rates to increase and sampling rates of 5-10 min are becoming increasingly common. In this paper we explore the relationship between extreme sea levels and estimated return periods based on hourly and shorter sampling periods in three tide-gauges one at the Atlantic coasts of Spain (Coruña), one in the western Mediterranean (Malaga) and one in the N. Adriatic (Trieste). Significant differences of several centimetres are found in the hourly and 5 min extremes. These reflect in significant underestimation of the 50-year return levels which in Trieste reach 38 cm. A theoretical relationship between the high and the low sampling rate of extremes is also tested. Thus updated 50-year return levels for the Mediterranean and the coasts of the Iberian peninsula are produced assuming that the differences identified in the various stations generalise to other tide-gauge (hourly) records for which hourly values have been analysed earlier.

  16. The 10-year natural history of simple renal cysts.

    PubMed

    Terada, Naoki; Arai, Yoichi; Kinukawa, Naoko; Terai, Akito

    2008-01-01

    We previously reported the natural history of renal cysts, with a mean follow-up of 6 years. Here, we extended the follow-up period to 10 years. From January 1993 to August 2006, 61 patients diagnosed with renal cysts were followed for up to 14 years (mean 9.9 years). The sequential changes in renal cyst size were plotted against patient age, and the rate of increase in cyst size per year was calculated for each individual. Those cyst characteristics known to predict aggressiveness were analyzed. The majority of the cysts increased in size and number. The average size increase and the average rate of enlargement in all cysts were 1.6 mm and 3.9% per year, respectively. Several cysts, especially multiloculated cysts, increased rapidly during the first 2 to 3 years, but then the rate of growth tended to decelerate with time. By using univariate analyses, age, laterality and cyst shape were revealed to be significant predictors of aggressiveness. The multivariate analysis revealed that age was the most significant predictor. Renal neoplasms originating from the renal cysts appeared in 2 patients during the follow-up period. The rate of size increase of the neoplasm-bearing cysts was similar to that of the other benign renal cysts in the same age category. The simple renal cysts continued to increase in size over 10 years, and sometimes increased rapidly, especially in younger patients. However, their growth rates appeared to decrease with age. There seems to be no specific pattern observed in the neoplasm-bearing renal cysts.

  17. Ocular microbiology trends in Edmonton, Alberta: a 10-year review.

    PubMed

    Zhou, Alysia W; Lee, Mao-Cheng; Rudnisky, Christopher J

    2012-06-01

    Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized as an increasingly common cause of nosocomial infections since the 1980s.(1) Reports of ocular infections due to MRSA are composed primarily of case reports. But a recent report from the United States suggests that ocular infections due to MRSA are about to become more common than methicillin-sensitive S. aureus (MSSA).(2) However, this observation is not consistent with anecdotal experience at the University of Alberta. The purpose of this study is to evaluate the ocular microbiology trends in a tertiary care eye center in Canada. Cross-sectional study using a computer search of the DynaLIFE(DX) Diagnostic Laboratory Services database for all positive ocular microbiology cultures and in vitro antibiotic susceptibilities performed in the Edmonton area. Over a 10-year period, between 2000 and 2010, 6.4% of S. aureus isolates were MRSA; there were 2030 MSSA and 129 MRSA isolates, including 46 MSSA and 4 MRSA isolates from deep eye cultures. The prevalence of MRSA over the total number of S. aureus isolates, regardless of specimen source, steadily increased in the 10-year period, from 0.5% in 2002 to 12.6% in 2010. Gram-positive cocci were the most common organisms to cause ocular infections (82.6%). In vitro susceptibility of ocular MSSA and MRSA samples demonstrated 100% sensitivity to vancomycin. The prevalence of MRSA ocular infections, although still uncommon, appears to be increasing in Edmonton, Alberta. Copyright © 2012 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  18. 10 years of Terra Outreach over the Internet

    NASA Astrophysics Data System (ADS)

    Yuen, K.; Riebeek, H.; Chambers, L. H.

    2009-12-01

    1 Author Yuen, Karen JPL (818) 393-7716 2 Author Riebeek, Holli Sigma Space Corporation (department) at NASA Goddard Space Flight Center (Institution), Greenbelt, Maryland 3 Author Chambers, Lin NASA Abstract: Since launch, Terra has returned about 195 gigabytes (level 0) of data per day or 1 terabyte every 5 days. Few outlets were able to accommodate and quickly share that amount of information as well as the Internet. To honor the 10-year anniversary of the launch of Terra, we would like to highlight the education and outreach efforts of the Terra mission on the Internet and its reach to the science attentive public. The Internet or web has been the primary way of delivering Terra content to different groups- from formal and informal education to general public outreach. Through the years, many different web-based projects have been developed, and they were of service to a growing population of the science attentive public. One of Terra’s original EPO activities was the Earth Observatory. It was initially dedicated to telling the remote sensing story of Terra, but quickly grew to include science and imagery from other sensors. The web site allowed for collaboration across NASA centers, universities and other organizations by exchanging and sharing of story ideas, news and images. The award winning Earth Observatory helped pave the way for the more recently funded development of the Climate Change website. With its specific focus on climate change studies, once again, Terra stories and images are shared with an even more specific audience base. During the last 10 years, Terra as a mission has captured the imagination of the public through its visually stunning and artistically arresting images. With its five instruments of complementary but unique capabilities, the mission gave the world not just pretty pictures, but scientific data-based images. The world was able to see from space everything from calving icebergs to volcanic eruption plumes and the eye of a

  19. Natural 10-year history of simple renal cysts.

    PubMed

    Park, Hongzoo; Kim, Choung-Soo

    2015-05-01

    To carry out long-term follow-up of patients diagnosed with asymptomatic simple renal cysts (SRCs). One hundred fifty-eight adult patients in whom SRCs were incidentally diagnosed by abdominal ultrasonography or abdominopelvic computed tomography between August 1994 and June 2004 were followed up for over 10 years. The retrospective analysis investigated sequential changes in the size, shape, and Bosniak classification of the renal cyst and analyzed risk factors for increased size and growth rate of the cysts. The median follow-up period was 13.9 years (range, 10.0-19.8 years). Median patient age was 54.1 years (range, 22-86 years). Mean maximal cyst size was 33 mm (range, 2-90 mm). Among all patients, 120 (76%) showed a mean increase in maximum renal cyst diameter of 1.4 mm (6.4%) per year. Age at initial diagnosis was a risk factor for increased renal cyst maximum diameter. The probability of an increase in maximum diameter of an SRC was 7.1 times greater in patients aged 50 years or older at diagnosis than in those aged less than 50 years. However, among patients with an increased maximum diameter, the mean growth rate was lower in patients aged ≥50 years than in those aged <50 years. About three-quarters of adult patients with accidentally diagnosed SRCs presented with an increased maximum diameter. The only risk factor for an increase in maximum diameter was age. In patients with an increase in the maximum diameter, the growth rate of the maximum diameter was 6.4% per year during 10 years and decreased with age.

  20. The academic occupational physician as consultant. A 10-year perspective.

    PubMed

    McCunney, R J

    1994-04-01

    The academic community has long served the private sector in a consultant capacity in engineering and in the sciences. With respect to occupational medicine, physicians, when working for industry, have generally practiced in a health care setting. Within the past 10 years, however, the business sector has placed more attention on the health implications of its operations as a result of regulations, liability, and rising health care costs. These issues, which go beyond traditional clinical responsibilities, have furthered the need for businesses to receive strategic medical advice to effectively operate and to maintain a competitive edge. One particular business sector, the chemical industry, has been challenged seriously because of legitimate as well as perceived health risks associated with the production and use of its products. This paper describes the professional experiences over a 10-year period (1983 to 1993) of an occupational physician working as a consultant to an international chemical company. Services have related to epidemiology, health policy, toxicology, plant oversight as well as serving as a health advisor on matters involving the relation between business and health. An academic affiliation with an occupational medicine residency program has facilitated access to related occupational health professionals to assist in problem solving and research. Opportunities for consulting in occupational medicine will depend upon the nature of the organization as well as the personal and professional characteristics of the physician. Requests for these types of services, however, are likely to expand in the near future, primarily as a result of wider awareness of the implications of work on health, increased litigation, and government regulations.

  1. Amiodarone for refractory cardiac arrhythmias: 10-year study.

    PubMed Central

    Leak, D; Eydt, J N

    1986-01-01

    Over a 10-year period 130 patients with drug-resistant cardiac arrhythmias associated mainly with coronary artery disease and its complications were treated with amiodarone. The drug controlled all the tachyarrhythmias associated with the Wolff-Parkinson-White syndrome, 95% of the ventricular arrhythmias, including recurrent ventricular tachycardia and fibrillation, and 92% of the supraventricular arrhythmias. The maximum duration of therapy was 111 months and the mean 34 months. Side effects occurred in 34% of the patients, and there was one withdrawal from therapy per 15.3 patient-years of treatment. The commonest cause of withdrawal was nausea, which was significantly related (p less than 0.01) to a drug interaction with digoxin and diuretics. Reversible neurologic complications occurred in eight patients (6%), and acute myositis was recognized for the first time. Pulmonary infiltration developed in four patients (3%), who were receiving 600 mg of amiodarone per day. The rates of side effects and of withdrawal from therapy differed significantly between the patients whose maintenance doses were 600 and 200 mg/d, at 59% v. 6% (p less than 0.01) and 32% v. 0% (p less than 0.05) respectively. Thus, amiodarone is a very effective antiarrhythmic that can be administered over long periods with acceptable rates of side effects and withdrawal provided the minimal effective dose is used; 400 mg/d or less is desirable. PMID:3948063

  2. Changing trends in the surgical treatment of Ménière's disease: results of a 10-year survey.

    PubMed

    Silverstein, Herbert; Lewis, William B; Jackson, Lance E; Rosenberg, Seth I; Thompson, Jack H; Hoffmann, Karen K

    2003-03-01

    In order to discern trends in surgical procedures used to treat Ménière's disease in the United States during the 1990s, we mailed a questionnaire to 700 members of the American Otological Society and the American Neurotology Society. These physicians were asked about the frequency, results, and complications of surgical procedures for Ménière's disease that they had performed between Jan. 1, 1990, and Dec. 31, 1999. Questionnaires were returned by 137 surgeons (19.6%). Their responses indicated that the number of vestibular neurectomies, labyrinthectomies, and endolymphatic sac surgeries all decreased during 1999. Meanwhile, the use of office-administered intratympanic gentamicin therapy increased rapidly throughout the entire 10-year period, and by 1999 it had become the most frequently used invasive treatment for Ménière's disease. Surgeons now seem to reserve inpatient procedures for cases where intratympanic gentamicin fails to control vertigo.

  3. OFS research over the last 10 years at CQU & UESTC

    NASA Astrophysics Data System (ADS)

    Rao, Yunjiang

    2012-06-01

    This article reviews my new optical fiber sensing (OFS) research activities in China for the last ten years at Chongqing University and University of Electronic Science and Technology of China, since I returned from UK in 1999. The research progress in long period fiber gratings (LPFGs), distributed fiber sensing systems and microfiber sensors is introduced. For LPFGs, the processing method with high-frequency CO2 laser pulses types of LPFGs fabricated and the related applications for both optical sensing and optical communication are described. For distributed fiber sensing systems, the fiber-optic polarization optical time domain reflectometer (POTDR), fiber-optic phase-sensitive optical time domain reflectometer (Φ-OTDR) and Brillouin optical time-domain analyzer (BOTDA) are developed, respectively. For microfiber sensors, we mainly focus on the knot resonator and its application for sensing of the refractive index and acceleration, etc.

  4. The Cryptophlebia Leucotreta Granulovirus—10 Years of Commercial Field Use

    PubMed Central

    Moore, Sean D.; Kirkman, Wayne; Richards, Garth I.; Stephen, Peter R.

    2015-01-01

    In the last 15 years, extensive work on the Cryptophlebia leucotreta granulovirus (CrleGV) has been conducted in South Africa, initially in the laboratory, but subsequently also in the field. This culminated in the registration of the first CrleGV-based biopesticide in 2004 (hence, the 10 years of commercial use in the field) and the second one three years later. Since 2000, more than 50 field trials have been conducted with CrleGV against the false codling moth, Thaumatotibia leucotreta, on citrus in South Africa. In a representative sample of 13 field trials reported over this period, efficacy (measured by reduction in larval infestation of fruit) ranged between 30% and 92%. Efficacy was shown to persist at a level of 70% for up to 17 weeks after application of CrleGV. This only occurred where the virus was applied in blocks rather than to single trees. The addition of molasses substantially and sometimes significantly enhanced efficacy. It was also established that CrleGV should not be applied at less than ~2 × 1013 OBs per ha in order to avoid compromised efficacy. As CrleGV-based products were shown to be at least as effective as chemical alternatives, persistent and compatible with natural enemies, their use is recommended within an integrated program for control of T. leucotreta on citrus and other crops. PMID:25809025

  5. Family support, family income, and happiness: a 10-year perspective.

    PubMed

    North, Rebecca J; Holahan, Charles J; Moos, Rudolf H; Cronkite, Ruth C

    2008-06-01

    This study examined the role of 2 central aspects of family life--income and social support--in predicting concurrent happiness and change in happiness among 274 married adults across a 10-year period. The authors used hierarchical linear modeling to investigate the relationship between family income and happiness. Income had a small, positive impact on happiness, which diminished as income increased. In contrast, family social support, measured by 3 subscales, Cohesion, Expressiveness, and Conflict, showed a substantial, positive association with concurrent happiness, even after controlling for income. Furthermore, family income moderated the association between family social support and concurrent happiness; family social support was more strongly associated with happiness when family income was low than when family income was high. In addition, change in family social support was positively related to change in happiness, whereas change in family income was unrelated to change in happiness. These findings suggest that happiness can change and underscore the importance of exploring more deeply the role that family relationships play in facilitating such change. (c) 2008 APA, all rights reserved

  6. A 10-year retrospective study on odontogenic tumors in Iran.

    PubMed

    Taghavi, Nasim; Rajabi, Moones; Mehrdad, Leili; Sajjadi, Samad

    2013-01-01

    The aim of this study was to review cases of odontogenic tumors diagnosed in two pathology centers in Tehran, Iran, during a 10-year period. Patients' records were seen at two teaching pathology Centre's of Shahid Beheshti University between the months of March 2000 to 2010 with histologic diagnosis of any type of odontogenic tumors. The records were analyzed for frequency, age, sex, site, as well as clinical, radiographic and histopathologic findings. Of 30706 biopsies, 4767 (15.5%) cases were diagnosed as oral and maxillofacial lesions. Among these, 720 cases were tumoral with 188 (26.1%) cases of odontogenic tumors. Tumors with odontogenic epithelium origin formed 70.2% of total numbers of odontogenic tumors. Mixed odontogenic tumors and tumors of odontogenic ectomesenchyme comprised 12.2% and 17.5% of the cases respectively. Ameloblastoma, with a frequency of 62.2% was the most common tumor in this review which was followed by odontoma and odontogenic myxoma. Although there are few studies on odontogenic tumors in literature, the comparison of our results with existing data shows significant differences in the distribution of tumors and age of patients, which may be due to ethnic features and geographic distribution of patients. Future studies on other ethnic groups are essential for further clarification of the findings in this research.

  7. A 10-year review of false aneurysms in Nottingham.

    PubMed Central

    Berridge, D. C.; Earnshaw, J. J.; Makin, G. S.; Hopkinson, B. R.

    1988-01-01

    Over a 10-year period, twenty-nine patients who developed false aneurysms were reviewed retrospectively. The diagnosis was delayed for as long as 7 months in the eight patients who developed aneurysms following trauma. However, all these patients had an excellent outcome after surgery. The results were also good in patients with non-infected false aneurysms after vascular reconstruction, with 17 of the 19 patients having the affected limb saved by remedial surgery. The main principle of remedial surgery was to perform the simplest surgical procedure possible. The results in infected false aneurysms were poor and management should be considered along the lines laid down for graft infection. The incidence of false aneurysms may be reduced by the use of suitable non-absorbable sutures, prevention of tension at an anastomosis and prevention of infection. However, degeneration of the arterial wall is thought to be a major cause of false aneurysms and is, of course, beyond control. Recent technical advances such as digital subtraction angiography, labelled leucocyte scanning and computed tomography have all contributed to improvements in the management of false aneurysms. Images fig. 1 fig. 3 PMID:3415176

  8. 10 years of surveillance of human tularaemia in France.

    PubMed

    Mailles, A; Vaillant, V

    2014-11-13

    Tularaemia has been mandatorily notifiable in France since October 2002. The surveillance aims to detect early any infection possibly due to bioterrorism and to follow up disease trends. We report the results of national surveillance from 2002 to 2012. A case is defined as a patient with clinical presentation suggestive of tularaemia and biological confirmation of infection or an epidemiological link with a biologically confirmed case. Clinical, biological and epidemiological data are collected using a standardised notification form. From 2002 to 2012, 433 cases were notified, with a median age of 49 years (range 2 to 95 years) and a male–female sex ratio of 1.8. Most frequent clinical presentations were glandular tularaemia (n=200; 46%) and ulceroglandular tularaemia (n=113; 26%). Most frequent at-risk exposures were handling hares (n=179; 41%) and outdoor leisure exposure to dust aerosols (n=217; 50%). Tick bites were reported by 82 patients (19%). Ten clusters (39 cases) were detected over the 10-year period, as well as a national outbreak during winter 2007/2008. The tularaemia surveillance system is able to detect small clusters as well as major outbreaks. Surveillance data show exposure to dust aerosols during outdoor leisure activities to be a major source of contamination in France.

  9. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... foreign income, war profits, and excess profits taxes are determined on the basis of an accounting period... outstanding stock; (10) For the annual accounting period, the amount of the corporation's: (i) Current earnings and profits; (ii) Foreign income, war profits, and excess profits taxes paid or accrued;...

  10. 26 CFR 1.6038-2 - Information returns required of United States persons with respect to annual accounting periods...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... foreign income, war profits, and excess profits taxes are determined on the basis of an accounting period... outstanding stock; (10) For the annual accounting period, the amount of the corporation's: (i) Current earnings and profits; (ii) Foreign income, war profits, and excess profits taxes paid or accrued;...

  11. 26 CFR 1.6038-1 - Information returns required of domestic corporations with respect to annual accounting periods...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... corporation or foreign subsidiary regularly computes its income in keeping its books. The term “annual... additional 5 percent for each 3-month period, or fraction thereof, during which such failure continues after...

  12. 10-Year Framework of Programmes on Sustainable Consumption and Production

    EPA Pesticide Factsheets

    One of the important programmatic outcomes from the U.N. Conference on Sustainable Development (Rio+20) was the adoption of the 10-Year Framework of Programmes (10YFP) on Sustainable Consumption and Production (SCP).

  13. [Tinea capitis: Main mycosis child. Epidemiological study on 10years].

    PubMed

    Kallel, A; Hdider, A; Fakhfakh, N; Belhadj, S; Belhadj-Salah, N; Bada, N; Chouchen, A; Ennigrou, S; Kallel, K

    2017-09-01

    Despite the changes in their epidemiology, and the improving level of hygiene of the population, tinea capitis is still considered a public health problem in our country, and is the most common type of dermatophytosis in our country. The aim of our study was to evaluate the epidemiological, clinical and mycological features of tinea capitis in children encountered in the Tunis region. A retrospective study concerned 1600 children aged 6 months to 15 years suspected to have tinea capitis was conducted in Parasitology-Mycology laboratory, Rabta hospital, over a 10-years period (2005-2014). Dermatophyte infections were confirmed using scalp scrapings examinated with direct microscopy using potash at 30% and/or culture on Sabouraud medium agar. Tinea capitis diagnosis was confirmed in 947 cases (59.18%). The sex ratio was 2.61 and the average age of 6.28 years with predominance in the age group of 4 to 8 years (52.27%). The most common clinical presentation was ringworm (87.65%). Ringworm large plaque was predominant (65.9%). Direct examination was positive in 884 cases (93.35%). Microsporic tinea was the most frequent (63.25%) followed by trichophytic tinea (29.78%). Positive cultures of dermatophytes were obtained in 912 cases (96.30%). The following dermatophyte species were isolated: Microsporum canis (67%), Trichophyton violaceum (31.68%), Trichophyton mentagrophytes (0.66%), Microsporum audouinii (0.22%), Trichophyton schoenleinii (0.22%) and Microsporum gypseum (0.22%). M. canis is currently the most frequently incriminated species in tinea capitis in Tunisia. This change is related to a change in behavior of our population, in fact the cat; main reservoir of M. canis cohabiting increasingly with Tunisian families. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  14. Justification for Rhinoseptoplasty in Children – Our 10 Years Overview

    PubMed Central

    Kopacheva-Barsova, Gabriela; Nikolovski, Nikola

    2016-01-01

    BACKGROUND: Nasal septal surgery and rhinoplasty are controversial in children. Traditionally, an attitude of restraint has been employed by most surgeons till an empirical age of 16 to 18 years. This is to avoid the possible adverse effects that the growth spurts may have on the nose and midface region. AIM: The aim of this paper was to present the results of rhinoplasty in children in order to restore the anatomy and function or to promote normal development and outgrowth of the nose. MATERIAL AND METHODS: Ninety seven children aged 6-14, with severe nose deformities and breathing problems through the nose, were admitted for septo/rhinoplasty at the University Clinic for Ear, Nose and Throat, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Republic of Macedonia. At our Clinic, they have been observed and photographed (with parent permission) in the period of 10 years (2006-2016). The most frequent cause of these deformities was the nasal trauma in early childhood which was ignored or untreated. All of them rhino/septoplasty were indicated in accordance with the above-mentioned recommendations for rhino/septoplasty in early childhood and in adolescents. RESULTS: In 51 children and adolescents septoplasty were prepared. Mostly there was a group of younger children age from 6-10 (68%) and adolescents (32%). In the other 31 children and adolescents, septorhinoplasty was prepared. Mostly there were children older than 12 years old and adolescents (70%). Only 30% were younger than 12 years, of course with severe nasal breathing problems, nasal septal deformities and deformities of the nasal pyramid. CONCLUSION: The growth centres of the nose have to be avoided if possible; long-term nasal issues will theoretically be minimised. If the surgeon replaces it, the cartilage of the nose becomes straighter but still intact. PMID:27703562

  15. Periodization

    PubMed Central

    Lorenz, Daniel S.; Reiman, Michael P.; Walker, John C.

    2010-01-01

    Background: Clinicians are constantly faced with the challenge of designing training programs for injured and noninjured athletes that maximize healing and optimize performance. Periodization is a concept of systematic progression—that is, resistance training programs that follow predictable patterns of change in training variables. The strength training literature is abundant with studies comparing periodization schemes on uninjured, trained, and untrained athletes. The rehabilitation literature, however, is scarce with information about how to optimally design resistance training programs based on periodization principles for injured athletes. The purpose of this review is to discuss relevant training variables and methods of periodization, as well as periodization program outcomes. A secondary purpose is to provide an anecdotal framework regarding implementation of periodization principles into rehabilitation programs. Evidence Acquisition: A Medline search from 1979 to 2009 was implemented with the keywords periodization, strength training, rehabilitation, endurance, power, hypertrophy, and resistance training with the Boolean term AND in all possible combinations in the English language. Each author also undertook independent hand searching of article references used in this review. Results: Based on the studies researched, periodized strength training regimens demonstrate improved outcomes as compared to nonperiodized programs. Conclusions: Despite the evidence in the strength training literature supporting periodization programs, there is a considerable lack of data in the rehabilitation literature about program design and successful implementation of periodization into rehabilitation programs. PMID:23015982

  16. 10 years of surprises at Saturn: CAPS and INMS highlights

    NASA Astrophysics Data System (ADS)

    Coates, A. J.; Waite, J. H.

    2014-04-01

    The Cassini mission at Saturn has provided many surprises on Saturn's rapidly rotating magnetosphere and its interaction with the diverse moons, as well as its interaction with the solar wind. One of the early discoveries was the water-rich composition of the magnetosphere. Its structure and dynamics indicate remarkable injections, periodicities and interchange events. Enceladus, orbiting at 4 RS, was found to have plumes of water vapour and ice which are the dominant source for the inner magnetosphere. Charged water clusters, charged dust and photoelectrons provide key populations in the 'dusty plasma' seen here, as well as chemical complexity in the plume material. Direct pickup is seen near Enceladus and field aligned currents create a spot in Saturn's aurora. At Titan, orbiting at 20 RS, heavy negative and positive ions are seen in the ionosphere, as well as neutrals, all of which have surprising chemical complexity. These provide the source for Titan's haze. Ionospheric plasma is seen in Titan's tail, enabling ion escape to be estimated at 7 tonnes per day. Saturn's ring ionosphere was seen early in the mission, which was oxygen rich and produced photoelectrons; a return will be made in 2017. At Rhea, pickup positive and negative ions indicated weak atmospheres sustained by energetic particle impact, seen in the neutrals also. A weak atmosphere was also seen at Dione. The exosphere production process operates at Jupiter's moons also. Here we review some of the key new results, and discuss the implications for other solar system contexts.

  17. Actual 10-Year Survivors Following Resection of Adrenocortical Carcinoma

    PubMed Central

    Tran, Thuy B.; Postlewait, Lauren M.; Maithel, Shishir K.; Prescott, Jason D.; Wang, Tracy S.; Glenn, Jason; Phay, John E.; Keplinger, Kara; Fields, Ryan C.; Jin, Linda X.; Weber, Sharon M.; Salem, Ahmed; Sicklick, Jason K.; Gad, Shady; Yopp, Adam C.; Mansour, John C.; Duh, Quan-Yang; Seiser, Natalie; Solorzano, Carmen C.; Kiernan, Colleen M.; Votanopoulos, Konstantinos I.; Levine, Edward A.; Hatzaras, Ioannis; Shenoy, Rivfka; Pawlik, Timothy M.; Norton, Jeffrey A.; Poultsides, George A.

    2017-01-01

    Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options beyond surgical resection. The characteristics of actual long-term survivors following surgical resection for ACC have not been previously reported. Method Patients who underwent resection for ACC at one of 13 academic institutions participating in the US Adrenocortical Carcinoma Group from 1993 to 2014 were analyzed. Patients were stratified into four groups: early mortality (died within 2 years), late mortality (died within 2–5 years), actual 5-year survivor (survived at least 5 years), and actual 10-year survivor (survived at least 10 years). Patients with less than 5 years of follow-up were excluded. Results Among the 180 patients available for analysis, there were 49 actual 5-year survivors (27%) and 12 actual 10-year survivors (7%). Patients who experienced early mortality had higher rates of cortisol-secreting tumors, nodal metastasis, synchronous distant metastasis, and R1 or R2 resections (all P < 0.05). The need for multi-visceral resection, perioperative blood transfusion, and adjuvant therapy correlated with early mortality. However, nodal involvement, distant metastasis, and R1 resection did not preclude patients from becoming actual 10-year survivors. Ten of twelve actual 10-year survivors were women, and of the seven 10-year survivors who experienced disease recurrence, five had undergone repeat surgery to resect the recurrence. Conclusion Surgery for ACC can offer a 1 in 4 chance of actual 5-year survival and a 1 in 15 chance of actual 10-year survival. Long-term survival was often achieved with repeat resection for local or distant recurrence, further underscoring the important role of surgery in managing patients with ACC. PMID:27633419

  18. The management of HIV in pregnancy: A 10-year experience.

    PubMed

    Raffe, Sonia F; Savage, Charlotte; Perry, Louisa A; Patel, Amie; Keith, Tricia; Howell, Richard; Bradley, Robert; Bomont, Rob; Fidler, Katy; Gilleece, Yvonne

    2017-03-01

    The package of care to reduce HIV mother to child transmission (MTCT) has evolved significantly since trials of ante and intrapartum antiretroviral therapy (ART) in 1994. In the UK MTCT rate has fallen from 25.6% in the 1990s to 0.46%. We review the management of HIV in pregnancy in Brighton in the context of evolving guidelines. HIV, obstetric and neonatal notes of all HIV positive women, pregnant between 2003 and 2014, were reviewed. 97 pregnancies in 75 women were identified, resulting in 79 live births. Antenatal HIV diagnosis was made in 22 (28%). The proportion of pregnancies in those with known HIV at conception increased over the time period. At conception 58 (60%) were on ART, 33 (57%) of who continued on their original regimen. 34 (35%) initiated ART following conception: 14 known to be HIV positive, 20 diagnosed during pregnancy. Two did not start ART (1 due to miscarriage, 1 as diagnosed post-delivery) and in three cases ART history was unavailable due to transfer to alternative centres. ART was initiated on average at 22 weeks gestation (range 6-34). 4(5%) received Zidovudine (AZT) monotherapy, all before 2006. Choice of combination ART (cART) varied with time reflecting changing guidelines. Prior to 2008 an AZT containing regimen was used in 83% versus 8% after. Planned mode of delivery was documented in 73: 30(41%) planned a normal vaginal delivery (NVD), 43(59%) a caesarean section (CS). The viral load (VL) was <50copies/mL in 58(76%) at 36 weeks and 64(84%) at delivery. 90% with a detectable VL at 36 weeks delivered via CS. 100% received neonatal post-exposure prophylaxis (PEP): 68(88%) AZT monotherapy, 9(12%) cART. 84% initiated PEP within four hours. 90% completed 28days. 8(10%) babies experienced side effects. In the 10-year review period, one infant (1.3%) was diagnosed HIV positive. Both mother and infant received care in accordance with guidelines, including neonatal PEP within 4hours. Care of the HIV positive pregnant woman in Brighton has

  19. Return to work after treatment for primary breast cancer over a 6-year period: results from a prospective study comparing patients with the general population.

    PubMed

    Noeres, Dorothee; Park-Simon, Tjoung-Won; Grabow, Jördis; Sperlich, Stefanie; Koch-Gießelmann, Heike; Jaunzeme, Jelena; Geyer, Siegfried

    2013-07-01

    Only little research has been conducted on breast cancer survivors returning to work in Germany. This paper explores two questions: (1) Does breast cancer lead to an increased drop-out of paid work? (2) Do other factors, apart from their illness, help explain breast cancer survivors' (temporary) retirement from work? To the best of our knowledge, this is the first comparative and prospective study on breast cancer survivors returning to work in Germany. We consider this work to be a relevant research for three reasons: (1) It exceeds the observation period of previous international studies by another 3 years. (2) By including the comparison with a population sample, it allows to take the specific situation of breast cancer patients into account. This refers to their illness as well as to the socio-economic context. (3) It combines qualitative and quantitative methods in order to receive patients' individual interpretations. The analysis is based on a sample of 227 breast cancer patients, participating in a prospective study on the role of psychosocial factors in the long-term course of breast cancer and a random sample of 647 age-matched women living in northern Germany. Employment and demographic data were observed directly before primary surgery (2002-2004), 1 year later (2003-2005) and again 5 years later (2008-2010). In addition, qualitative interviews at the three different observations served as a basis for quantitative data analyses, which were mainly performed by logistic regression models. One year after primary surgery, nearly three times as many cancer survivors had left their job as compared to the women in the reference group. For breast cancer survivors, a lower level of education, part-time employment, the severity of work-related difficulties and participation in inpatient rehabilitation correlated significantly with the failure to return to work. Six years after surgery, the probability of returning to work was still only half as high among breast

  20. Juvenile Hyaline Fibromatosis: A 10-year Follow-up

    PubMed Central

    Baltacioglu, Esra; Guzeldemir, Esra; Sukuroglu, Erkan; Yildiz, Kadriye; Yuva, Pinar; Aydin, Güven; Karacal, Naci

    2017-01-01

    Juvenile hyaline fibromatosis (JHF) is a rare hereditary disease with an autosomal recessive transmission. JHF is characterized by papulonodular skin lesions, osteolytic bone lesions, flexural joint contractures, and gingival hyperplasia and usually diagnosed in infancy or early childhood. JHF is thought to be a disorder of collagen metabolism and characterized by homogenous amorphous eosinophilic material and fibrous tissue. We report the case of a 14-year-old male child with multiple papulonodular skin lesions, progressive flexion contractures of joints, and severe gingival hyperplasia, with a 10-year follow-up. Although the lesions were totally removed thrice during the last 10 years, they recurred rigorously.

  1. Looking forward, looking back-10 years in urology.

    PubMed

    Albersen, Maarten; Cartwright, Rufus; Choyke, Peter; Goldenberg, S Larry; Goldman, Howard; Lawrentschuk, Nathan; Linehan, W Marston; Murphy, Declan; Nagler, Harris; Scardino, Peter; Shortliffe, Linda; Stenzl, Arnulf; Theodorescu, Dan

    2014-11-01

    When Nature Reviews Urology launched in 2004, the field of urology was vastly different to that which we work in today, and the past 10 years have seen the field change immensely. As a specialty on the forefront of cutting-edge innovation, urologists are often the first to embrace new technologies and ideas. In this Viewpoint, members of the Nature Reviews Urology advisory board were asked what they thought was the most important change, issue or innovation in urology in the past 10 years, and what they expected to be the most important in the next decade. Here are their opinions.

  2. Expected innovations of optical lithography in the next 10 years

    NASA Astrophysics Data System (ADS)

    Owa, Soichi; Hirayanagi, Noriyuki

    2016-03-01

    In the past 10 years, immersion lithography has been the most effective high volume manufacturing method for the critical layers of semiconductor devices. Thinking of the next 10 years, we can expect continuous improvement on existing 300 mm wafer scanners with better accuracy and throughput to enhance the total output value per input cost. This value productivity, however, can be upgraded also by larger innovations which might happen in optical lithography. In this paper, we will discuss the possibilities and the impossibilities of potential innovation ideas of optical lithography, which are 450 mm wafer, optical maskless, multicolor lithography, and metamaterial.

  3. Students as Teachers: Effectiveness of a Peer-Led STEM Learning Programme over 10 Years

    ERIC Educational Resources Information Center

    Drane, Denise; Micari, Marina; Light, Gregory

    2014-01-01

    Peer-led small-group learning has been used quite extensively in the US to enhance performance and retention of undergraduate students in science, math, and engineering classes. This study presents the results from an evaluation of a peer-led small-group programme at a research university in the US over a 10-year period across five disciplines…

  4. Handedness in Swedish 10-year-olds, Some Background and Associated Factors.

    ERIC Educational Resources Information Center

    Gillberg, Christopher; And Others

    1984-01-01

    Aims to obtain prevalence figures for left-handedness among 10-year-old Swedish children; to replicate some findings concerning Bishop's (1980) extended pathological left-handedness hypothesis; to evaluate the influence of factors such as the child's sex and reduced optimality in the pre-, peri-, and neonatal period; and to determine the…

  5. Post-fire saguaro community: impacts on associated vegetation still apparent 10 years later

    Treesearch

    Marcia Narog; Ruth Wilson

    2005-01-01

    Fire impacts on saguaro (Carnegiea gigantea) associated vegetation were studied in unburned and burned areas over a 10 year post-fire period after the 1993 Vista View fire, Tonto National Forest, Arizona. Many associated species, crucial for saguaro survival, regenerate by vegetative growth after fire. Bushes were the most common nearest-neighbor,...

  6. Epicormic branching on central Appalachian hardwoods 10 years after deferment cutting

    Treesearch

    Gary W. Miller

    1996-01-01

    Epicormic branching was monitored over a 10-year period following deferment cutting in four central Appalachian hardwood stands in West Virginia. Data from 545 codominant residual trees indicated that the average number of epicormic branches on the butt and second 16-foot log sections increased significantly for the first 2 years after treatment. For upper log...

  7. Handedness in Swedish 10-year-olds, Some Background and Associated Factors.

    ERIC Educational Resources Information Center

    Gillberg, Christopher; And Others

    1984-01-01

    Aims to obtain prevalence figures for left-handedness among 10-year-old Swedish children; to replicate some findings concerning Bishop's (1980) extended pathological left-handedness hypothesis; to evaluate the influence of factors such as the child's sex and reduced optimality in the pre-, peri-, and neonatal period; and to determine the…

  8. A 10-Year Assessment of Information and Communication Technology Tasks Required in Undergraduate Agriculture Courses

    ERIC Educational Resources Information Center

    Edgar, Leslie D.; Johnson, Donald M.; Cox, Casandra

    2012-01-01

    This study sought to assess required information and communication technology (ICT) tasks in selected undergraduate agriculture courses in a land-grant university during a 10-year period. Selected agriculture faculty members in the fall 1999 (n = 63), 2004 (n = 55), and 2009 (n = 64) semesters were surveyed to determine the ICT tasks they required…

  9. Optimism, Pessimism, Mutuality, and Gender: Predicting 10-Year Role Strain in Parkinson's Disease Spouses

    ERIC Educational Resources Information Center

    Lyons, Karen S.; Stewart, Barbara J.; Archbold, Patricia G.; Carter, Julie H.

    2009-01-01

    Purpose: There is wide variability in how spouses providing care respond to their care situations. Few studies focus on the roles of both intra- and interpersonal factors in long-term spousal care, particularly in the context of Parkinson's disease (PD). The current study uses longitudinal data over a 10-year period to examine the roles of…

  10. A 10-Year Assessment of Information and Communication Technology Tasks Required in Undergraduate Agriculture Courses

    ERIC Educational Resources Information Center

    Edgar, Leslie D.; Johnson, Donald M.; Cox, Casandra

    2012-01-01

    This study sought to assess required information and communication technology (ICT) tasks in selected undergraduate agriculture courses in a land-grant university during a 10-year period. Selected agriculture faculty members in the fall 1999 (n = 63), 2004 (n = 55), and 2009 (n = 64) semesters were surveyed to determine the ICT tasks they required…

  11. Adolescent Drug Trafficking Trends in the United Kingdom--A 10-Year Retrospective Analysis

    ERIC Educational Resources Information Center

    Vale, Ellen Louise Eva; Kennedy, Patrick John

    2004-01-01

    This paper reports data from HM Customs and Excise (HMCE) of recorded cases of adolescent drug trafficking through all sea and air points of entry into the UK over a 10-year period (May 1992-May 2002). We report the characteristics of 38 cases of mixed gender and nationality ranging in age between 13 and 18 years who have been apprehended by HMCE…

  12. Psychopathy and Offending From Adolescence to Adulthood: A 10-Year Follow-Up

    ERIC Educational Resources Information Center

    Gretton, Heather M.; Hare, Robert D.; Catchpole, Rosalind E. H.

    2004-01-01

    This study examined the predictive validity of the Hare Psychopathy Checklist: Youth Version (PCL:YV; A. E. Forth, D. S. Kosson, & R. D. Hare, 2003) from adolescence to early adulthood. The authors coded the PCL:YV using file information and collected criminal record information over a 10-year follow-up period on 157 boys, ages 12 through 18,…

  13. Optimism, Pessimism, Mutuality, and Gender: Predicting 10-Year Role Strain in Parkinson's Disease Spouses

    ERIC Educational Resources Information Center

    Lyons, Karen S.; Stewart, Barbara J.; Archbold, Patricia G.; Carter, Julie H.

    2009-01-01

    Purpose: There is wide variability in how spouses providing care respond to their care situations. Few studies focus on the roles of both intra- and interpersonal factors in long-term spousal care, particularly in the context of Parkinson's disease (PD). The current study uses longitudinal data over a 10-year period to examine the roles of…

  14. The Israeli National Genetic database: a 10-year experience.

    PubMed

    Zlotogora, Joël; Patrinos, George P

    2017-03-16

    The Israeli National and Ethnic Mutation database ( http://server.goldenhelix.org/israeli ) was launched in September 2006 on the ETHNOS software to include clinically relevant genomic variants reported among Jewish and Arab Israeli patients. In 2016, the database was reviewed and corrected according to ClinVar ( https://www.ncbi.nlm.nih.gov/clinvar ) and ExAC ( http://exac.broadinstitute.org ) database entries. The present article summarizes some key aspects from the development and continuous update of the database over a 10-year period, which could serve as a paradigm of successful database curation for other similar resources. In September 2016, there were 2444 entries in the database, 890 among Jews, 1376 among Israeli Arabs, and 178 entries among Palestinian Arabs, corresponding to an ~4× data content increase compared to when originally launched. While the Israeli Arab population is much smaller than the Jewish population, the number of pathogenic variants causing recessive disorders reported in the database is higher among Arabs (934) than among Jews (648). Nevertheless, the number of pathogenic variants classified as founder mutations in the database is smaller among Arabs (175) than among Jews (192). In 2016, the entire database content was compared to that of other databases such as ClinVar and ExAC. We show that a significant difference in the percentage of pathogenic variants from the Israeli genetic database that were present in ExAC was observed between the Jewish population (31.8%) and the Israeli Arab population (20.6%). The Israeli genetic database was launched in 2006 on the ETHNOS software and is available online ever since. It allows querying the database according to the disorder and the ethnicity; however, many other features are not available, in particular the possibility to search according to the name of the gene. In addition, due to the technical limitations of the previous ETHNOS software, new features and data are not included in the

  15. Prematures with and without Regressed Retinopathy of Prematurity: Comparison of Long-Term (6-10 Years) Ophthalmological Morbidity.

    ERIC Educational Resources Information Center

    Cats, Bernard P.; Tan, Karel E. W. P.

    Reporting long-term ophthalmologic sequelae among ex-prematures at 6 to 10 years of age, this study compares 42 ex-premature infants who had had regressed forms of retinopathy of prematurity (ROP) during the neonatal period with 42 matched non-ROP ex-premature controls at 6 to 10 years of age. Subjects were subdivided into four groups: (1) ROP…

  16. Prematures with and without Regressed Retinopathy of Prematurity: Comparison of Long-Term (6-10 Years) Ophthalmological Morbidity.

    ERIC Educational Resources Information Center

    Cats, Bernard P.; Tan, Karel E. W. P.

    Reporting long-term ophthalmologic sequelae among ex-prematures at 6 to 10 years of age, this study compares 42 ex-premature infants who had had regressed forms of retinopathy of prematurity (ROP) during the neonatal period with 42 matched non-ROP ex-premature controls at 6 to 10 years of age. Subjects were subdivided into four groups: (1) ROP…

  17. CELBAN™: A 10-Year Retrospective Catherine Lewis & Blanche Kingdon

    ERIC Educational Resources Information Center

    Lewis, Catherine; Kingdom, Blanche

    2016-01-01

    This article provides a 10-year review by the test developers of the Canadian English Language Benchmark Assessment for Nurses (CELBAN™). From 2004 to 2014, the development, implementation, national administration, and operations of CELBAN and CELBAN-related products and services were the responsibility of the test developers and team at the…

  18. 10 Years of Media Literacy Education in K-12 Schools

    ERIC Educational Resources Information Center

    Daunic, Rhys

    2011-01-01

    When the author started working with teachers and students on classroom multimedia productions a little over 10 years ago, he had not yet encountered the term "media literacy", nor did he realize he had joined a long standing international movement of media literacy educators. Serendipitous exposure to "old-media" texts by Neil Postman and Noam…

  19. Neuropsychological aspects of 10-year-old children.

    PubMed

    Osborn, Ellen; Pereira, Liliane Desgualdo

    2012-01-01

    To characterize neuropsychological aspects of 10-year-old children. Out of 30 children, 26 cognitively normal 10-year-old public school students answered tests extracted from Luria-Nebraska Neuropsychological Battery: Children's Revision. The study was transversal. Descriptive and inferential statistical analysis were carried out. Most of the 10-year-old children retold a story (69.2%), understood it making correct inference (84.6%) and reproduced it adequately in writing (76.9%)--14.9% was the average number of incorrectly written words and 0.179 was the errors per written word coefficient. Besides, 53.8% showed logical thought process and 73.1% had a correct notion of "x more than...". They got five out of eight in the visuo-spatial test, an intermediary result. These results show that the tertiary areas of units II and III are developed in most 10-year-old children. The most frequent types of written mistakes were: oral influence (26.3%), multiple representation (22.5%) and omission (18.4%). As to coding principles, the mostly uncomplied with rule was vowel nasalization at end of syllable (23,53%). Ten-year-old children in the studied population understood and reproduced a story orally and in writing with a low coefficient error/word. The majority completed the visuospatial tests and presented logical thought process. When "x more than..." notion is absent it may be an indicator that all is not well in the reading/writing process.

  20. Career Theory Building in AJCD during Its Inaugural 10 Years.

    ERIC Educational Resources Information Center

    Prideaux, Lee-Ann; Creed, Peter

    2002-01-01

    A review of the first 10 years of the Australian Journal of Career Development identified 26 articles meeting methodological criteria. These topics predominated: cross-sectional analyses, Holland's theory of vocational choice, self-efficacy/self-concept theory, gender issues, and career counseling/career education. A need for an…

  1. Headshaking in a 10-year-old Thoroughbred mare

    PubMed Central

    2004-01-01

    Abstract A 10-year-old Thoroughbred mare was presented with a 2.5-week history of headshaking. Based on a thorough physical examination, blood analysis, and a fine needle aspirate of an enlarged thyroid gland, a tentative diagnosis of seasonal idiopathic headshaking was made. Treatment with cyproheptadine was attempted. PMID:15025153

  2. Duodenal adenocarcinoma in a 10-year-old boy.

    PubMed

    Mohamed, Zouari; Habib, Bouthour; Rabia, Ben Abdallah; Youssef, Hlel; Riath, Ben Malek; Youssef, Gharbi; Nejib, Kaabar

    2014-01-01

    Gastrointestinal malignancies are extremely rare in the paediatric population and duodenal cancers represent an even more unusual entity. It represents 0.3-1% of all gastrointestinal tumours. A case report of a 10-year-old boy with duodenal adenocarcinoma is reported and the difficulties of diagnosing and treating this rare tumour are discussed.

  3. Sugar maple provenance study: West Virginia outplanting - 10-year results

    Treesearch

    G. W. Wendel; W. J. Gabriel

    1980-01-01

    After 10 years, survival of sugar maple (Acer saccharum Marsh.) provenances outplanted in West Virginia did not differ significantly. Total height, height growth and dbh measurements were significantly different among provenances. Fifty percent of the trees had major forks below 9.0 feet. Thirty-eight percent of the trees had no forks but 71 percent...

  4. Smart Start: Celebrating 10 Years, 1993-2003.

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start, a public-private initiative celebrating 10 years of operation, invests in high quality early care and education services for all children, birth to age five, and their families in North Carolina. The initiative funds programs to improve the quality, affordability, and availability of child care as well as children's health and family…

  5. Career Theory Building in AJCD during Its Inaugural 10 Years.

    ERIC Educational Resources Information Center

    Prideaux, Lee-Ann; Creed, Peter

    2002-01-01

    A review of the first 10 years of the Australian Journal of Career Development identified 26 articles meeting methodological criteria. These topics predominated: cross-sectional analyses, Holland's theory of vocational choice, self-efficacy/self-concept theory, gender issues, and career counseling/career education. A need for an…

  6. Technology for Distance Education: A 10 Year Prospective.

    ERIC Educational Resources Information Center

    Bates, A. W.

    This paper provides an overview of new technologies likely to be widely available within the next 10 years for teaching in Europe. It begins by presenting a framework which draws distinctions between different technologies based on their educational applications, i.e., for teaching or operational purposes, for communicating within or between…

  7. Interrogating the Subject: Queering Elementary Education, 10 Years On

    ERIC Educational Resources Information Center

    Sears, James T.

    2009-01-01

    This paper provides an overview of the contributions to this special issue in the context of a wider argument about the notion of queering elementary education. When "Queering Elementary Education" was published 10 years ago there was very little writing or research on matters related to primary education, and just finding experienced educators to…

  8. Flowerpot sequestrum of the Humerus Neglect for 10 years!!

    PubMed Central

    Sharma, Rakesh

    2012-01-01

    Introduction: Neglected cases of osteomyelitis are not uncommon. We present a case of humerus osteomyelitis neglected for 10 years and presented with a sequestrum protruding out of the arm in the shape of a flowerpot. Such a long duration of neglect and a startling presentation are rare and have implications not only on healthcare but also reflect the socio-economic and cultural fabric of the society. Case Report: 22 year old lady presented with history of bone jutting out of right arm since last 10 years. She had a trivial injury to the arm 10 years back followed by pain and fever. She was treated by local osteopath and ‘registered’ doctors but developed wound over the arm with purulent discharge. On and off treatment with dressing was continued with symptomatic relief but in few weeks bone fragment started protruding out of the wound. The size of bone protruding from the wound increased gradually with on and off history of discharge since 10 years. Clinically a flowerpot shaped sequestrum was seen protruding from the arm. Radiographs showed a defined diaphyseal sequestrum of the humerus with continuity of the bone maintained by new bone formation. Sequestrectomy was done and at one year follow up patient was fine with no recurrence of infection Conclusions: Lack of health infrastructure, ignorance, and other social and cultural factors lead to such bad wounds. Even with such long history a single surgery for debridement and sequestrectomy was all that was needed for healing the patient.

  9. 10-year Field Measurement Program of Post-Wildfire Tree Root Decay, Kootenay National Park, British Columbia

    NASA Astrophysics Data System (ADS)

    Martin, Y. E.; Johnson, E. A.; Kroeker, S.

    2013-12-01

    Tree population dynamics in subalpine forests of the Canadian Rockies are dominated by wildfire disturbance (Gallaway et al., 2009), with wildfire return intervals most often being shorter than the potential lifespan of trees. These crown wildfires kill all trees, resulting in a gradual decline of tree root strength in shallow soils in the immediate post-wildfire years. Tree root networks have been shown to provide mechanical reinforcement of shear strength in shallow soils (Schmidt et al., 2001; Roering et al., 2003). Therefore, decreases in tree root reinforcement in post-wildfire years may result in increased debris slide and debris flow activity during this time period (e.g., Benda and Dunne, 1997; Martin, 2007; Jackson and Roering, 2009). To our knowledge, our study is the first that has measured tree root strength annually for 10 years following a crown wildfire to document the nature and timing of tree root decay. Suggestions have been made that studies documenting the decay of tree roots following timber harvesting provide a reasonable analogue for post-wildfire tree root decay; drainage basin modeling studies considering hillslope erosion resulting from episodic wildfires have had to rely on this assumption (e.g., Benda and Dunne, 1997; Martin, 2007). Herein, we present our annual field measurements of post-wildfire tree root strength made over the past 10 years at a post-wildfire site in Kootenay National Park, Canadian Rockies. The episodic nature of crown wildfire occurrence over time in these forests results in periods of tree root decay in the immediate post-fire years, and an associated susceptibility for mass wasting during these time periods. In July 2003, two large crown fires were ignited by lightning in Kootenay National Park, British Columbia, Canada and merged to burn approximately 17 000 hectares. Our field measurements were made in the subalpine forest of Hawk Creek drainage basin, Kootenay National Park. Measurements of tree root

  10. Anatomical and functional graft survival, 10 years after epikeratoplasty in keratoconus

    PubMed Central

    Panda, Anita; Gupta, Anoop K; Sharma, Namrata; Nindrakrishna, Sasikala; Vajpayee, Rasik

    2013-01-01

    Purpose: To report outcomes of epikeratoplasty in keratoconus (KC), utilizing manually-prepared plano donor lenticules in terms of flattening of the cone, reduction in astigmatism and improvement in the visual acuity. Materials and Methods: Patients with KC, having visual acuity <20/200, astigmatism >12 diopters (D) but without corneal opacity underwent epikeratoplasty, using manually prepared plano donor lenticules from fresh or M.K preserved corneas, between 1990 - 2000 and followed for 10 years, were included in this report. Visual acuity slit-lamp-biomicroscopy, keratometry, and refraction were performed at 8 weeks, 12 weeks, and 6 months for all 59 patients. The same were carried out at 1 year, 5 years, and 10 years depending upon the availability of the patient for that period. Results: Of the 59 patients, only 26 were available for follow-up after 10 years. At 3 months, 1 year and 5 years, best corrected visual acuity of (BCVA) ≥20/60 were achieved in 84.7%, 84.4% and 80.3% of eyes, respectively. BCVA was 73% at 10-year follow- up, which was due to the presence of posterior subcapsular cataract (PSC). The average keratometric astigmatism and average flattening in diopters stabilized at the end of 3 months, which remained constant at 1, 5, and 10-year follow-up. The average diopter of myopia was stabilized by 1 year, which was almost same at 10 year. Graft was clear in all but 1 eye at 10 year follow-up. Conclusion: Epikeratoplasty is a useful technique for keratoconic eyes without apical scarring who fail or unable to use contact lenses. PMID:23275216

  11. Return period of great Himalayan earthquakes in Eastern Nepal: evidence from the Patu and Bardibas strands of the Main Frontal Thrust

    NASA Astrophysics Data System (ADS)

    Bollinger, L.; Tapponnier, P.; Sapkota, S. N.; Klinger, Y.; Rizza, M.; van der Woerd, J.

    2013-12-01

    The return period of large Himalayan earthquakes remains poorly constrained. Despite the repeated destruction of ancient cities in and afoot the mountain range, attested by historical chronicles, no definitive link between known events and specific segments of the Main Himalayan Thrust system has been established. Furthermore, few paleo-seismological records have unambiguously documented the occurrence of multiple, similar events at the same location along that system. In east-central Nepal, however, primary ruptures and modern surface deformation due to the great 1255 and 1934 earthquakes were recently discovered in the Sir Khola valley. The ruptures are associated with a long record of multiple terraces uplifted by the Main Frontal Thrust. To investigate further the recent slip history of the thrust in that area, we surveyed in detail its two main, overlapping splays: the Patu Thrust to the North, and the Bardibas Thrust, ≈ 5 km to the South. We updated the regional geomorphic and neo-tectonic map of active faulting and folding, acquired three shallow, ≈ 1.5 km-long, 400 m-deep seismic profiles, refreshed a natural rivercut cliff, excavated trenches and dated recent sedimentary records across both structures. In addition to the 1255 and 1934 earthquakes, the uplift of terraces in the hanging-wall of the Patu thrust requires two more events in the last 2400 +/-100 years BP. Given the thrust deep geometry and dip, and the hangingwall uplift rate, each event on the Patu splay appears to have accommodated 9 to 12.5 m of slip. Trenching of a flexural fold scarp on the Bardibas splay suggests that growth events generated transient episodes of proximal colluvial deposition, augmenting the number of past earthquakes recorded to a minimum of 6 in the last 4500 years. Overall, assuming that both splays rupture coevally, our observations thus imply that the average return period of great Himalayan earthquakes in eastern Nepal is between [700-933] years and 907 +/- 150

  12. Helping a 10-year-old Haitian girl with vaginitis.

    PubMed

    Leveille-Tulce, Anne Marie B

    2014-06-01

    The purpose of this case study is to demonstrate how nurses who work with Haitian children and families can use NANDA-I (diagnosis), the Nursing Outcomes Classification, and the Nursing Interventions Classification to assist a 10-year-old child with symptoms of vaginitis. The case study derives from the author's experience and literature sources. This case study demonstrates a nurse's clinical decision making while providing care to a 10-year-old girl with symptoms of vaginitis. Increased knowledge and awareness about appropriate health behaviors can increase patients' power and enable them to freely act and adopt health behaviors to improve health outcomes. Placing patients at the center of the nursing process and partnering with patients to plan and develop interventions enable them to take actions and improve health outcomes. © 2013 NANDA International.

  13. Mandibular Dentigerous Cyst in a 10-Year-Old Child

    PubMed Central

    Bhardwaj, Bindu; Sharma, Sunil; Agarwal, Prateek; Bhamboo, Amit; Rastogi, Komal

    2016-01-01

    Dentigerous cyst is the most common odontogenic cyst. It is characterized by a unilocular radiolucent lesion that encloses permanent tooth buds or, under certain circumstances, displaced tooth buds. Buccal bony expansion and a missing tooth is the most common clinical feature. Various treatment modalities have been mentioned in the literature for management of dentigerous cysts. This article presents a left mandibular dentigerous cyst in a 10-year-old boy. Marsupialization was the treatment of choice and a denturelike space maintainer was provided. Long-term follow-up revealed good healing of the bony lesion. How to cite this article Bhardwaj B, Sharma S, Chitlangia P, Agarwal P, Bhamboo A, Rastogi K. Mandibular Dentigerous Cyst in a 10-Year-Old Child. Int J Clin Pediatr Dent 2016;9(3): 281-284. PMID:27843264

  14. 10 Years at Saturn, and More Excitement to Come!

    NASA Astrophysics Data System (ADS)

    Edgington, S. G.; Spilker, L. J.; Altobelli, N.

    2014-04-01

    After 10 years in orbit, the Cassini-Huygens Mission to Saturn, a collaboration of NASA, ESA, and ASI, continues to wow the imagination. Every year Cassini produces answers to questions raised by the Voyager flybys, while at the same time posing new questions that can only be answered with a long duration mission using a flagship-class spacecraft. In this talk, we sample a few of Cassini's discoveries from the past decade and give an overview of what comes next.

  15. [Percutaneous transluminal angioplasty (PTA), 10 years of experience].

    PubMed

    Estevan Solano, J M; García-Cosío, J; Rodríguez, E; Barreiro, A; Maynar, M

    1991-01-01

    Authors present their experiences during 10 years (1980-89) with the treatment of peripheral arteriopathies with the ATP. Between a total of 455 procedures, an accumulative permeability of 82% in the iliac sector and 71% in the femoro-popliteal sector in elective indications was reached. The total availability of this therapeutic method, the accurate selection of indications and the valious cooperation between Angioradiology and Vascular Surgery Departments should be noted.

  16. Atypical presentation of macrophagic myofasciitis 10 years post vaccination.

    PubMed

    Ryan, Aisling M; Bermingham, Niamh; Harrington, Hugh J; Keohane, Catherine

    2006-12-01

    Macrophagic myofasciitis (MMF) is an uncommon inflammatory disorder of muscle believed to be due to persistence of vaccine-derived aluminium hydroxide at the site of injection. The condition is characterised by diffuse myalgias, arthralgia and fatigue. We describe a patient with histologically confirmed MMF whose presentation was atypical with left chest and upper limb pain beginning more than 10 years post vaccination. Treatment with steroids led to symptomatic improvement. Although rare, clinicians should consider MMF in cases of atypical myalgia.

  17. Intellectual development at 10 years in early treated congenital hypothyroidism.

    PubMed Central

    Simons, W F; Fuggle, P W; Grant, D B; Smith, I

    1994-01-01

    Fifty nine children born between 1978 and 1981 with congenital hypothyroidism detected by neonatal screening were assessed at 10 years using the Wechsler intelligence scale for children, together with 59 matched classroom controls. Thirty one children with severe hypothyroidism who had pretreatment plasma thyroxine concentrations of 40 nmol/l or less had a mean (SD) full scale IQ score of 104.7 (15.1), compared with a mean (SD) score of 114.6 (16.3) for the 28 less severely affected children who had pretreatment thyroxine levels greater than 40 nmol/l, and mean (SD) scores of 114.5 (12.8) and 114.8 (13.8) respectively for the 31 and 28 control children. In the hypothyroid children the IQ scores at 10 years were closely related to the IQ scores at 5 years and at 3 years. It is concluded that the deficit in IQ score found at 3 and 5 years in children with severe hypothyroidism is still evident at the age of 10 years. PMID:7526803

  18. MMI's Metadata and Vocabulary Solutions: 10 Years and Growing

    NASA Astrophysics Data System (ADS)

    Graybeal, J.; Gayanilo, F.; Rueda-Velasquez, C. A.

    2014-12-01

    The Marine Metadata Interoperability project (http://marinemetadata.org) held its public opening at AGU's 2004 Fall Meeting. For 10 years since that debut, the MMI guidance and vocabulary sites have served over 100,000 visitors, with 525 community members and continuous Steering Committee leadership. Originally funded by the National Science Foundation, over the years multiple organizations have supported the MMI mission: "Our goal is to support collaborative research in the marine science domain, by simplifying the incredibly complex world of metadata into specific, straightforward guidance. MMI encourages scientists and data managers at all levels to apply good metadata practices from the start of a project, by providing the best guidance and resources for data management, and developing advanced metadata tools and services needed by the community." Now hosted by the Harte Research Institute at Texas A&M University at Corpus Christi, MMI continues to provide guidance and services to the community, and is planning for marine science and technology needs for the next 10 years. In this presentation we will highlight our major accomplishments, describe our recent achievements and imminent goals, and propose a vision for improving marine data interoperability for the next 10 years, including Ontology Registry and Repository (http://mmisw.org/orr) advancements and applications (http://mmisw.org/cfsn).

  19. Trabecular metal tibial knee component still stable at 10 years.

    PubMed

    Henricson, Anders; Nilsson, Kjell G

    2016-10-01

    Background and purpose - Total knee replacement (TKR) in younger patients using cemented components has shown inferior results, mainly due to aseptic loosening. Excellent clinical results have been reported with components made of trabecular metal (TM). In a previous report, we have shown stabilization of the TM tibial implants for up to 5 years. In this study, we compared the clinical and RSA results of these uncemented implants with those of cemented implants. Patients and methods - 41 patients (47 knees) aged ≤ 60 years underwent TKR. 22 patients (26 knees) received an uncemented monoblock cruciate-retaining (CR) tibial component (TM) and 19 patients (21 knees) received a cemented NexGen Option CR tibial component. Follow-up examination was done at 10 years, and 16 patients (19 knees) with TM tibial components and 17 patients (18 knees) with cemented tibial components remained for analysis. Results - 1 of 19 TM implants was revised for infection, 2 of 18 cemented components were revised for knee instability, and no revisions were done for loosening. Both types of tibial components migrated in the first 3 months, the TM group to a greater extent than the cemented group. After 3 months, both groups were stable during the next 10 years. Interpretation - The patterns of migration for uncemented TM implants and cemented tibial implants over the first 10 years indicate that they have a good long-term prognosis regarding fixation.

  20. Trabecular metal tibial knee component still stable at 10 years

    PubMed Central

    Henricson, Anders; Nilsson, Kjell G

    2016-01-01

    Background and purpose Total knee replacement (TKR) in younger patients using cemented components has shown inferior results, mainly due to aseptic loosening. Excellent clinical results have been reported with components made of trabecular metal (TM). In a previous report, we have shown stabilization of the TM tibial implants for up to 5 years. In this study, we compared the clinical and RSA results of these uncemented implants with those of cemented implants. Patients and methods 41 patients (47 knees) aged ≤ 60 years underwent TKR. 22 patients (26 knees) received an uncemented monoblock cruciate-retaining (CR) tibial component (TM) and 19 patients (21 knees) received a cemented NexGen Option CR tibial component. Follow-up examination was done at 10 years, and 16 patients (19 knees) with TM tibial components and 17 patients (18 knees) with cemented tibial components remained for analysis. Results 1 of 19 TM implants was revised for infection, 2 of 18 cemented components were revised for knee instability, and no revisions were done for loosening. Both types of tibial components migrated in the first 3 months, the TM group to a greater extent than the cemented group. After 3 months, both groups were stable during the next 10 years. Interpretation The patterns of migration for uncemented TM implants and cemented tibial implants over the first 10 years indicate that they have a good long-term prognosis regarding fixation PMID:27357222

  1. Avian response to bottomland hardwood reforestation: the first 10 years

    USGS Publications Warehouse

    Twedt, D.J.; Wilson, R.R.; Henne-Kerr, J.L.; Grosshuesch, D.A.

    2002-01-01

    Bttomland hardwood forests were planted on agricultural fields in Mississippi and Louisiana using either predominantly Quercus species (oaks) or Populus deltoides (eastern cottonwood). We assessed avian colonization of these reforested sites between 2 and 10 years after planting. Rapid vertical growth of cottonwoods (circa 2 - 3 m / yr) resulted in sites with forest structure that supported greater species richness of breeding birds, increased Shannon diversity indices, and supported greater territory densities than on sites planted with slower-growing oak species. Grassland birds (Spiza americana [Dickcissel], and Sturnella magna [Eastern Meadowlark]) were indicative of species breeding on oak-dominated reforestation # 10 years old. Agelaius phoeniceus (Red-winged Blackbird) and Colinus virginianus (Northern Bobwhite) characterized cottonwood reforestation # 4 years old, whereas 14 species of shrub-scrub birds (e.g., Passerina cyanea [Indigo Bunting]) and early-successional forest birds (e.g., Vireo gilvus [Warbling Vireo]) typified cottonwood reforestation 5 to 9 years after planting. Rates of daily nest survival did not differ between reforestation strategies. Nest parasitism increased markedly in older cottonwood stands, but was overwhelmed by predation as a cause of nest failure. Based on Partners in Flight prioritization scores and territory densities, the value of cottonwood reforestation for avian conservation was significantly greater than that of oak reforestation during their first 10 years. Because of benefits conferred on breeding birds, we recommend reforestation of bottomland hardwoods include a high proportion of fast-growing, early successional species such as cottonwood.

  2. Patterns of treatment utilization and methamphetamine use during first 10 years after methamphetamine initiation.

    PubMed

    Brecht, Mary-Lynn; Lovinger, Katherine; Herbeck, Diane M; Urada, Darren

    2013-01-01

    The study examined joint trajectories of methamphetamine (MA) use and substance abuse treatment utilization and identified differences among pattern groups for a sample of 348 treated for MA use. Results from group-based trajectory modeling showed that treatment utilization during the first 10 years after initiation of MA use could be categorized into three distinctive patterns: about half the MA users have a pattern of low treatment utilization; one-fourth follow a quicker-to-treatment trajectory with higher probability of treatment during the first 5 years of MA use and less treatment in the next 5 years; and one-fourth have a slower-to-treatment trajectory with more treatment during the second half of the 10-year period. Four MA use patterns were identified: consistently low use, moderate, and high use, as well as a decreasing use pattern. Periods of greater likelihood of treatment participation were associated with periods of decreasing or lower frequency of MA use.

  3. Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients.

    PubMed

    Evensen, Julie; Røssberg, Jan Ivar; Barder, Helene; Haahr, Ulrik; Hegelstad, Wenche Ten Velden; Joa, Inge; Johannessen, Jan Olav; Larsen, T K; Melle, Ingrid; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2012-08-01

    Affective flattening has been described as enduring, but long term follow-up studies of first episode psychosis patients are lacking. The aim of this study was to follow the symptom development of flat affect (FA), over a 10 year follow-up period, with focus on prevalence, predictors and outcome factors including social functioning. Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. These were followed on PANSS item N1 (FA) from baseline through 5 follow-up assessments over 10 years. Patients were grouped as having never-present, improving, deteriorating, fluctuating or enduring FA. The groups were compared on baseline variables, variables at 10 year follow-up, and social functioning throughout the follow-up period. Twenty nine percent never displayed FA, 66% had improving, deteriorating or fluctuating FA, while 5% of patients had enduring FA. Premorbid social function predicted enduring FA. The patients with enduring, fluctuating and deteriorating FA did poorer on all outcome variables, including remission and recovery rates. The enduring FA group did significantly poorer in social functioning over the 10 year period. FA is expressed at some point of time in the majority of FEP patients in a 10 year follow-up period, and appears more fluctuant than expected from the relevant literature. FA is associated with poorer outcome after 10 years, and enduring FA to poorer social function at all points of assessment. Copyright © 2012 Elsevier B.V. All rights reserved.

  4. The abilities of improved schizophrenia patients to work and live independently in the community: a 10-year long-term outcome study from Mumbai, India

    PubMed Central

    Srivastava, Amresh Kumar; Stitt, Larry; Thakar, Meghana; Shah, Nilesh; Chinnasamy, Gurusamy

    2009-01-01

    Background The outcome of first episode schizophrenia has several determinants. Socioecological factors, particularly living conditions, migration, community and culture, not only affect the level of risk but also the outcome. Mega cities around the world show a unique socioecological condition that has several challenges for mental health. The present study reports on the long-term status of patients with schizophrenia in such a mega city: Mumbai, India. Aim This study aims to reveal the long-term outcome of patients suffering from schizophrenia with special reference to clinical symptoms and social functioning. Methods The cohort for this study was drawn from a 10-year follow-up of first episode schizophrenia. Patients having completed 10 years of consistent treatment after first hospitalisation were assessed on psychopathological and recovery criteria. Clinical as well as social parameters of recovery were evaluated. Descriptive statistics with 95% confidence intervals are provided. Results Of 200 patients recruited at the beginning of this study, 122 patients (61%) were present in the city of Mumbai at the end of 10-year follow-up study period. Among 122 available patients, 101 patients (50.5%) were included in the assessment at the end of 10-year follow-up study period, 6 patients (3.0%) were excluded from the study due to changed diagnosis, and 15 patients (7.5%) were excluded due to admission into long-term care facilities. This indicates that 107 out of 122 available patients (87.7%) were living in the community with their families. Out of 101 (50.5%) patients assessed at the end of 10 years, 61 patients (30.5%) showed improved recovery on the Clinical Global Impression Scale, 40 patients (20%) revealed no improvement in the recovery, 43 patients (72.9%) were able to live independently, and 24 patients (40%) were able to find employment. Conclusion With 10 years of treatment, the recovery rate among schizophrenia patients in Mumbai was 30.5%. Among the

  5. Anterior Cervical Discectomy and Fusion Outcomes over 10 Years: A Prospective Study.

    PubMed

    Buttermann, Glenn R

    2017-06-09

    Prospective cohort study with >10-year follow-up. To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes. Motion preservation treatments may result in improved long-term outcomes but need to be compared to long-term ACDF outcomes reference. Patients who had disc herniation, stenosis, and DDD and underwent ACDF with or without decompression were prospectively enrolled and followed for a minimum of 10 years with outcome assessment at various intervals. All 159 consecutive patients had autogenous tricortical iliac crest bone graft and plate instrumentation used. Outcomes included visual analog scale (VAS) for neck and arm pain; pain drawing; Oswestry Disability Index (ODI); and self-assessment of procedure success. Preoperative adjacent-level disc degeneration, pseudarthrosis, and secondary operations were analyzed. For all diagnostic groups, significant outcomes improvement was seen at all follow-up periods for all scales relative to preoperative scores. Outcomes were not related to age, gender, number of levels treated, and minimally to pre-existing degeneration at the adjacent level. The use of narcotic pain medication decreased substantially. Neurological deficits almost all resolved. Patient self-reported success ranged from 85% to 95%. Over the long term, additional surgery for pseudarthrosis (10%) occurred in the early follow-up period, and for adjacent segment degeneration (21%) which occurred linearly during the 10+ year follow-up period. ACDF leads to significantly improved outcomes for all primary diagnoses and was sustained for more than 10 years' follow-up. Secondary

  6. Depressive symptoms in first-episode psychosis: a 10-year follow-up study.

    PubMed

    Sönmez, Nasrettin; Røssberg, Jan Ivar; Evensen, Julie; Barder, Helene Eidsmo; Haahr, Ulrik; Ten Velden Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Hans; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2016-06-01

    The present study examined if any patient characteristics at baseline predicted depressive symptoms at 10 years and whether patients prone to depressive symptoms in the first year of treatment had a different prognosis in the following years. A total of 299 first-episode psychosis (FEP) patients with schizophrenia spectrum disorders were assessed for depressive symptoms with PANSS depression item (g6) at baseline, and 1, 2, 5 and 10 years of follow up. At 10 years, depressive symptoms were also assessed with Calgary Depression Scale for Schizophrenia (CDSS). A PANSS g6 ≥ 4 and CDSS score ≥ 6 were used as a cut-off score for depression. A total of 122 (41%) patients were scored as depressed at baseline, 75 (28%) at 1 year, 50 (20%) at 2 years, 33 (16%) at 5 years, and 35 (19%) at 10 years of follow up. Poor childhood social functioning and alcohol use at baseline predicted depression at 10 years of follow up. Thirty-eight patients were depressed at both baseline and 1 year follow up. This group had poorer symptomatic and functional outcome in the follow-up period compared to a group of patients with no depression in the first year of treatment. Depressive symptoms are frequent among FEP patients at baseline but decrease after treatment because their general symptoms have been initiated. Patients with poor social functioning in childhood and alcohol use at baseline are more prone to have depressive symptoms at 10 years of follow up. Patients struggling with depressive symptoms in the first year of treatment should be identified as having poorer long-term prognosis. © 2014 Wiley Publishing Asia Pty Ltd.

  7. Retired Status and Older Adults’ 10-Year Drinking Trajectories*

    PubMed Central

    Brennan, Penny L.; Schutte, Kathleen K.; Moos, Rudolf H.

    2010-01-01

    Objective: Little research has examined the role of retirement in shaping late-life drinking careers, and it has generally been limited to cross-sectional designs or short-term follow-ups that emphasize group-level comparisons of retirees and nonretirees. The purpose of this study was to determine the following: (a) the effect of retired status on older adults’ 10-year within-person drinking trajectories and (b) whether age, gender, income, health, and problem-drinker status account for or moderate this effect. Method: We first estimated older adults’ (baseline M= 62 years; n = 595) 10-year within-person drinking trajectories using three successively predictive multilevel regression models: unconditional growth, retired status alone, and retired status controlling for covariates. Next, we determined whether inclusion of Retired Status × Covariate interactions would improve prediction of the trajectories. Results: Participants’ drinking frequency declined moderately over the 10-year interval, and retired status hastened the decline. However, this effect disappeared once covariates were added to the model: Baseline poorer health, lower income, and current problem-drinker status predicted steeper decline in drinking frequency, whereas former problem-drinker status predicted slower decline. Lower income and current drinking problems also predicted steeper declines in amount of alcohol consumed. There were no statistically significant or uniquely contributive interactions between retired status and age, gender, health, income, or drinking problems for predicting late-life drinking trajectories. Conclusions: Baseline health, income, and problem-drinking history are more important than retired status for predicting older adults’ long-term within-person drinking trajectories. These factors—and recency of drinking problems—should be considered in future studies of retirement and late-life drinking patterns. PMID:20230712

  8. Andrology in China: current status and 10 years' progress

    PubMed Central

    Hong, Kai; Xu, Qing-Quan; Zhao, Yong-Ping; Gu, Yi-Qun; Jiang, Hui; Wang, Xiao-Feng; Zhu, Ji-Chuan

    2011-01-01

    Andrology has a long history in traditional Chinese medicine. There are records of male sexual health, male sexual dysfunction and male infertility from over thousands of years ago. Modern andrology in China had a late start, with the Chinese Andrology Association founded in 1995. Within last decade, andrology in China has grown rapidly. In this review article, we summarized the progress of andrology in last 10 years and outlined the current status of Chinese andrology with a special focus on progress in male erectile dysfunction, prostate diseases, male infertility and male hormonal contraception. PMID:21642997

  9. Motor Speech Disorders: Where Will We Be in 10 Years?

    PubMed

    Duffy, Joseph R

    2016-08-01

    Research and practice in the area of motor speech disorders (MSDs) will change in the next 10 years, most likely in evolutionary rather revolutionary ways. We are likely to see an increase in the understanding of the underpinnings of MSDs and refinements in assessment and diagnosis. Management approaches probably will be refined, as will how outcomes are measured. The evidence base for treatment efficacy will grow. Technology and changes in the health care system will have strong and overarching, but not easily predicted, influences. This article provides a broad overview of these and related issues, with some cautious predictions.

  10. Factitious purpura in a 10-year-old girl.

    PubMed

    Yamada, Kayo; Sakurai, Yoshihiko; Shibata, Mari; Miyagawa, Sachiko; Yoshioka, Akira

    2009-01-01

    We describe a 10-year-old girl who presented with bizarre purpura. Both congenital and autoimmune hemorrhagic disorders were excluded based on her past medical history and physical and laboratory findings. Child abuse was also ruled out as purpura continued to develop after child-family separation. Histologic examination of the skin lesions revealed disruption of collagen fiber bundles. This finding indicated application of external force, leading to a definitive diagnosis of factitious purpura. Although it is very rare in school-age children, the diagnosis of factitious purpura should be included in the differential diagnosis of purpura in children. Histologic analysis of skin biopsies may aid in establishing the diagnosis.

  11. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) watches as 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA, shakes hands with astronaut Dog Wheelock. Behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  12. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a laugh with VIP 10- year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  13. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a light moment during his meeting with 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  14. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) listens intently to 10-year- old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  15. Developing of 10-year EEZ seafloor mapping and research program

    USGS Publications Warehouse

    Lockwood, M.; Hill, G.W.

    1988-01-01

    The intent of expanding the exploration already begun on the outer continental shelf to the frontier of the EEZ (Exclusive Economic Zone) is to determine the "characteristics' and resource potential of this region. To coordinate this exploration, a Joint Office for Mapping and Research (JOMAR) has been established by the US Geological Survey (in the Department of the Interior) and the National Oceanic and Atmospheric Administration (in the Department of Commerce). JOMAR's main purpose is to help direct and coordinate ongoing and planned seafloor related activities in the EEZ and prepare a 10-year plan for mapping and research. -from Authors

  16. [Rounded atelectasis: a follow up of 10 years by CT].

    PubMed

    Bruyère, P J; Bartsch, P; Ghaye, B

    2005-10-01

    We report the case of a 69-year-old man who presented with a rounded atelectasis (RA). During a 10-year follow-up by Computed Tomography (CT), the lobe showed a progressive shrinkage, and a moderate increase in size of the lesion led to a percutaneous biopsy which confirmed the diagnosis. RA is an unusual form of lung consolidation. The major cause of RA is asbestosis. RA is usually asymptomatic and may simulate a pulmonary neoplasm on chest Xray. The diagnosis is made by CT, demonstrating the pathognomonic "comet tail sign". No treatment is required.

  17. Mucosal inflammation and incidence of crestal bone loss among implant patients: a 10-year study.

    PubMed

    Cecchinato, Denis; Parpaiola, Andrea; Lindhe, Jan

    2014-07-01

    The objective of this prospective study was to determine the prevalence and incidence of marginal bone loss and, in addition, peri-implantitis in subjects and implant sites after 10 years in function. One hundred and thirty-three subjects with a total of 407 implants that had been in function for about 5 years attended a follow-up visit in 2007 (visit 2; V2). 100 of the 133 subjects returned for a new clinical and radiographic examination in 2012 (visit 3; V3). The clinical examination included assessment of "bleeding on probing" (BoP+) and "probing pocket depth." Subjects with implant sites that in the radiograph exhibited crater-shaped marginal bone loss of >0.5 mm were identified as losers. During the interval between V2 and V3 (about 5 years), 13 implants in 7 subjects exhibited progressive bone loss and were removed. The overall amount of crestal bone loss that had occurred at the remaining implants between visit 1 (V1; ≥1 year of loading) and V3 (10 years) was small (0.36 ± 1.4 mm). The bone-level reduction was twice as great between V2 and V3 as between V1 and V2. Forty subjects and 75 (26%) implant sites exhibited marginal bone loss of >0.5 mm between V1 and V3. In the interval between V2 and V3, 37 new implant sites lost significant amounts of bone. During the entire 10-year period (V1-V3), 12% of patients and 5% of implants displayed signs of peri-implantitis (bone loss >0.5 mm, BoP+, PPD ≥6 mm), while in the V2-V3 interval, the corresponding numbers were 10% (patients) and 4% (implant sites). Sites with marginal bone loss of ≥1 mm were not common among implant patients. Peri-implantitis occurred in about 10% of patients and 4% of implant sites. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Citations to Australian Astronomy: 5- and 10-Year Benchmarks

    NASA Astrophysics Data System (ADS)

    Kenyon, Katherine H.; Paramasivam, Arjun; Tu, Jiachin; Zhang, Albert; Graham, Alister W.

    2012-03-01

    Expanding upon Pimbblet's 2011 analysis of career h-indices for members of the Astronomical Society of Australia, we provide additional citation metrics which are geared to quantifying the current performance of all professional astronomers in Australia. We have trawled the staff web-pages of Australian Universities, Observatories and Research Organisations hosting professional astronomers, and identified 384 PhD-qualified, research-active, astronomers in the nation. 132 of these are not members of the Astronomical Society of Australia. Using the SAO/NASA Astrophysics Data System, we provide the three following common metrics based on publications in the first decade of the 21st century (2001-2010): h-index, author-normalised citation count and lead-author citation count. We additionally present a somewhat more inclusive analysis, applicable for many early-career researchers, that is based on publications from 2006-2010. Histograms and percentiles, plus top-performer lists, are presented for each category. Finally, building on Hirsch's empirical equation, we find that the (10-year) h-index and (10-year) total citation count T can be approximated by the relation AS12011_IE1.gif for h>~5.

  19. Psychosocial and emotional outcomes 10 years following traumatic brain injury.

    PubMed

    Draper, Kristy; Ponsford, Jennie; Schönberger, Michael

    2007-01-01

    To investigate the association of psychosocial outcome 10 years following traumatic brain injury (TBI) with demographic variables, injury severity, current cognitive functioning, emotional state, aggression, alcohol use, and fatigue. Community-based follow-up. Fifty-three participants with mild to very severe TBI sustained 10 years previously and significant others. Sydney Psychosocial Reintegration Scale, Extended Glasgow Outcome Scale, Hospital Anxiety and Depression Scale, NFI Aggression scale, Fatigue Severity Scale, Alcohol Use Disorders Identification Test, neuropsychological tests of attention/processing speed, memory, and executive function. Psychosocial functioning was lowest in the occupational activity domain and highest in the living skills domains. Variables including education, posttraumatic amnesia duration, numerous cognitive measures, concurrent fatigue, aggression, anxiety, and depression were all significantly associated with psychosocial outcome, although the strength of correlations varied between ratings of participants with TBI and relatives. Posttraumatic amnesia duration was most strongly associated with psychosocial outcome measured by relatives; anxiety, aggression, and depression were the strongest predictors when ratings were assigned by participants with TBI. Self-reported fatigue, depression, and alcohol use were the strongest predictors of aggression. It is important to address problems with anxiety, depression, fatigue, and alcohol use as a possible means of improving long-term psychosocial outcome following TBI.

  20. Return to sexual activity and modern family planning use in the extended postpartum period: an analysis of findings from seventeen countries.

    PubMed

    Borda, Maria R; Winfrey, William; McKaig, Catharine

    2010-12-01

    Unintended pregnancies can lead to poor maternal and child health outcomes. Family planning use during the first year postpartum has the potential to significantly reduce at least some of these unintended pregnancies. This paper examines the relationship of menses return, breastfeeding status, and postpartum duration on return to sexual activity and use of modern family planning among postpartum women. This paper presents results from a secondary data analysis of Demographic and Health Surveys from 17 countries. For postpartum women, the return of menses, breastfeeding status, and postpartum duration are significantly associated with return to sexual activity in at least 10 out of the 17 countries but not consistently associated with family planning use. Only menses return had a significant association with use of modern family planning in the majority of countries. These findings point to the importance of education about pregnancy risk prior to menses return.

  1. Clinical and Radiographic Evaluation of a Resin-Based Root Canal Sealer: 10-Year Recall Data

    PubMed Central

    Zmener, Osvaldo; Pameijer, Cornelis H.

    2012-01-01

    Objectives. This retrospective clinical and radiographical study evaluated the 10-year outcome of one-visit endodontic treatment with gutta-percha and a methacrylate resin-based sealer. Methods. From an initial sample size of 180 patients, 89 patients with 175 root canals responded to a recall. Treatment outcome was based on predetermined clinical and radiographic criteria. Results. Root canals had been adequately filled to the working length in 80 teeth (89.88%), short in 6 instances (6.74%), while 3 (3.37%) with extrusion immediate postoperatively, showed no sealer in periradicular tissues. The difference in the outcomes of treatments with respect to age, gender, preoperative pulp or periapical status, the size of periapical lesions and the type of permanent restorations were not statistically significantly different (P > 0.05). Overall, 7 (7.86%) cases were considered clinically and radiographically a failure. A life table analysis showed a cumulative probability of success of 92.13% after 10 years with a 95% confidence interval of 83.0 to 94.0. Conclusions. The results of this retrospective clinical and radiographical study suggest that the tested methacrylate-resin based sealer used with gutta-percha performed similarly to other root canal sealers over a period 10 years. Clinical Implications. Considering the success rate after 10 years of this methacrylate resin-based sealer can be recommended as an alternative to other commonly used root canal sealers. PMID:22654909

  2. Implant-retained mandibular overdentures versus conventional dentures: 10 years of care and aftercare.

    PubMed

    Visser, Anita; Meijer, Henny J A; Raghoebar, Gerry M; Vissink, Arjan

    2006-01-01

    This 10-year prospective, randomized, clinical trial investigated the treatment outcome of edentulous patients treated with mandibular overdentures retained by 2 endosseous implants compared with conventional dentures in patients with or without vestibuloplasty. One hundred fifty-one edentulous patients (5 groups) with a symphyseal mandibular bone height between 8 and 25 mm participated. Sixty-two patients were treated with an overdenture retained by 2 implants (groups 1 and 3), 59 patients were treated with a conventional denture (groups 2 and 5), and 30 patients were treated with a conventional denture after preprosthetic vestibuloplasty (group 4). Patients who received conventional dentures but preferred implants later on could undergo implant surgery after 1 year of their initial treatment, but were analyzed in their original group. The prosthetic and surgical care and aftercare were scored during a 10-year evaluation period. One hundred thirty-three patients completed the 10-year follow-up evaluations. Forty-four percent of patients treated with conventional dentures switched within 10 years to implant-retained overdentures, versus 16% of the patients who were treated with conventional dentures after vestibuloplasty. On average, a greater time investment and more treatment sessions were needed in patients treated with implant-retained overdentures compared to patients treated with conventional dentures. Patients treated with an implant-retained overdenture need more treatment interventions and treatment time than patients treated with conventional dentures.

  3. 1992 Resource Program, 10 Year Plan : Draft II.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration's primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  4. 1992 Resource Program, 10 Year Plan : Draft II.

    SciTech Connect

    United States. Bonneville Power Administration.

    1992-05-01

    The Resource Program is the Bonneville Power Administration`s primary process for deciding how to meet future electricity resource needs, how much new resources to develop, which types of resources to acquire or option and how to go about acquiring them, and how much BPA will have to spend for these resources. Recognizing that BPA must make a long-term commitment to acquiring conservation effectively, the 1992 Resource Program outlines a 10-year plan. Draft 2 of the 1992 Resource Program provides a framework for discussing the funding levels proposed in the Programs in Perspective (PIP) process. Previous final resource programs have been released prior to the PIP process. This version of the Resource Program recognizes that the PIP discussions are an integral part of the resource decision-making process and, therefore, it will be finalized after PIP.

  5. Class III treatment using facial mask: Stability after 10 years

    PubMed Central

    Ramos, Adilson Luiz

    2014-01-01

    Early Class III malocclusion treatment may not have long-term stability due to mandibular growth. Although some features of this malocclusion point to a better prognosis, it is practically impossible for the orthodontist to foresee cases that require new intervention. Many patients need retreatment, whether compensatory or orthodontic-surgical. The present study reports the case of a Class III patient treated at the end of the mixed dentition with the use of a face mask followed by conventional fixed appliances. The case remains stable 10 years after treatment completion. It was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:25715726

  6. Prenatal diagnosis of cystic fibrosis: 10-years experience.

    PubMed

    Hadj Fredj, S; Ouali, F; Siala, H; Bibi, A; Othmani, R; Dakhlaoui, B; Zouari, F; Messaoud, T

    2015-06-01

    We present in this study our 10years experience in prenatal diagnosis of cystic fibrosis performed in the Tunisian population. Based on family history, 40 Tunisian couples were selected for prenatal diagnosis. Fetal DNA was isolated from amniotic fluid collected by transabdominal amniocentesis or from chronic villi by transcervical chorionic villus sampling. The genetic analysis for cystic fibrosis mutations was performed by denaturant gradient gel electrophoresis and denaturing high-pressure liquid phase chromatography. We performed microsatellites analysis by capillary electrophoresis in order to verify the absence of maternal cell contamination. Thirteen fetuses were affected, 21 were heterozygous carriers and 15 were healthy with two normal alleles of CFTR gene. Ten couples opted for therapeutic abortion. The microsatellites genotyping showed the absence of contamination of the fetal DNA by maternal DNA in 93.75%. Our diagnostic strategy provides rapid and reliable prenatal diagnosis at risk families of cystic fibrosis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  7. Spectacle prescribing among 10-year-old children.

    PubMed Central

    Stewart-Brown, S

    1985-01-01

    Between 10 and 12% of the 10-year-old children in the 1970 national birth cohort were prescribed a pair of spectacles. One-fifth of these children had no impairment of visual acuity and a further 15-20% had only minimal visual defects. Only two-thirds of children with spectacles could produce them when asked to do so at the survey school medical examination; this was particularly common among those in the lower social classes and among children who had no detectable impairment. The information presented in this paper combined with that from earlier national birth cohort studies suggests that overprescribing of spectacles to school children is very common. The financial implications of this overprescribing are discussed. PMID:4084477

  8. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) greets 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  9. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) presents a bag of special gifts to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  10. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) talks to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  11. The Troubling Trichotomy 10 Years Later: Where Are We Now?

    PubMed

    Barrocas, Albert

    2016-06-01

    A decade ago, "Nutrition Support and The Troubling Trichotomy: A Call To Action" was published in this journal, identifying existing conflicts among technological, ethical, and legal aspects of nutrition support therapy, particularly in terminal or end-of-life situations. Over the past 10 years, the American Society for Parenteral and Enteral Nutrition and others have responded to the action call. A "state of the trichotomy" reveals that while much has been achieved, differences in all 3 aspects will continue to exist due to their dynamic and ever-changing states. The technology arena has made it possible to increase the delivery of nutrition support in alternative settings with the use of telemedicine and social media. Critical/crucial conversations and earlier declarations of individual wishes for care and treatment while having decision-making capacity have been enhanced with the focus on patient-centered and family-centered care. The definition of death as brain death has been challenged in at least one instance. Conflicts between the state's interests and the individual's interests have added to recent legal controversies. Notwithstanding the progress made over the past 10 years, several challenges remain. The future challenges presented by the Troubling Trichotomy can be best confronted if we ACT-Accountability, Communication, and Teamwork. The focus of teamwork should move from multidisciplinary and interdisciplinary teams to transdisciplinary teams, reflecting the shift to function rather than form presented by the new healthcare environment. The transdisciplinary team will be able address the opportunities of the Troubling Trichotomy in the next decade by incorporating the 12 Cs, as detailed in the article. © 2016 American Society for Parenteral and Enteral Nutrition.

  12. Sense of well-being 10 years after stroke.

    PubMed

    Brunborg, Birgit; Ytrehus, Siri

    2014-04-01

    To describe factors that promote subjective well-being in a long-time perspective of 10 years after stroke. The research literature describes circumstances that are difficult to deal with after a stroke, but there is relatively little knowledge of factors that contribute to well-being in a longer-time perspective than two years after the incident. This study focuses on such conditions in a 10-year perspective. Qualitative study Qualitative in-depth interviews were carried out with nine stroke survivors. The interviews addressed their description of factors accounting for adaptation and subjective well-being after the stroke. Kvale and Brinkmann's (2008, Interview. Sage Publications, Inc., København) guidelines for qualitative research informed the analysis. Six major themes emerged from these analyses: (1) personal characteristics as the cause of positive adaptation to the new situation, (2) new meaningful activities, (3) new health habits, (4) social networks and family, (5) economical resources and (6) public help. Only a few of the survivors had received any home-based nursing care or health assistance, but they were nevertheless mainly satisfied with their rehabilitation outcome. Self-care, health literacy, stamina, a positive way of thinking and attention from family and friends seemed to be of immense importance for adaptation and well-being. Personal characteristics and synergy with significant others seem to be the most important factors for having a good and long life after a stroke. The results of this study will contribute to rehabilitation planning and to understanding, assisting and supporting stroke survivors in restoring a good life despite disabilities after the stroke. © 2013 John Wiley & Sons Ltd.

  13. Cocaine use during pregnancy and health outcome after 10 years.

    PubMed

    Minnes, Sonia; Min, Meeyoung O; Singer, Lynn T; Edguer, Marjorie; Wu, Miaoping; Thi, Pyone

    2012-11-01

    Women who used cocaine during pregnancy may become at risk for increased physical and mental health problems. Three hundred and twenty-one (158 cocaine use during pregnancy (PC), 163 no cocaine (NC)) women were assessed using the Health Survey Questionnaire (SF-36V2) 10 years after infant birth. Factors related to mental and physical health, and co-occurring with PC, were evaluated using multiple regression. Controlling for age and education, PC women reported poorer total perceived mental health (PMH) (46.3±.9 vs. 50.7±.9, p<.001), more bodily pain (48.1±1.0 vs. 51.5±1.0, p<.02) and poorer health perceptions (46.8±.9 vs. 49.7±.9, p<.03) than NC women. PC women had lower BMI (29% vs. 32%, p<.006), higher current alcoholic drinks per/week (4.05±15.5 vs. 1.29±3.51, p<.005) and number of cigarettes per day (9±10.6 vs. 4±6.5, p<.0001) and greater total life strain (Family Inventory of Life Events and Changes (FILE)) (4.6±4.9 vs. 3.2±3.2, p<.004) than NC women. Regression analyses indicated that body mass index (BMI) mediated the effect of prior cocaine use on perceived physical health (PPH) and total life strain had additive effects. Current cigarette use and total life stress partially mediated the effects of cocaine use on PMH and also had additive independent effects. PC use is a marker for poor health after 10 years. Mediators of these relationships (BMI, stressful life events and current tobacco use) should be considered when designing interventions to promote health. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  14. Variations in Titan's Ionospheric Densities over a 10 Year Time Period of the Cassini Mission

    NASA Astrophysics Data System (ADS)

    Madanian, H.; Cravens, T.; Richard, M. S.; Edberg, N. J. T.; Westlake, J. H.; Wahlund, J. E.; Waite, J. H., Jr.; Perryman, R.

    2015-12-01

    Titan hosts the most chemically complex atmosphere in the solar system. The first encounter of the Cassini spacecraft with Titan was in October 2004 with a closest approach altitude of 1147km. Since then the Cassini has made measurements of the ionospheric species over multiple flybys and has provided a unique opportunity to study long term effects on Titan's ionosphere including solar activity cycle. It has been shown that solar extreme ultraviolet radiation is the main source of ion production and production rates are highly dependent on solar zenith angle. We use data from the ion and Neutral Mass Spectrometer (INMS) and the Radio and Plasma Wave Science-Langmuir probe (RPWS-LP) instruments onboard the Cassini spacecraft to investigate changes in the ion composition of the ionosphere. We compare the observations with the results of our ionospheric models. Data from 21 targeted Titan flybys are used, covering the declining phase of solar cycle 23 into the double peak of solar cycle 24. We show that the ion densities have in fact increased during the high solar activity, especially at altitudes near the ionospheric peak, and unlike Earth, the Titan's thermosphere is contracted during high solar activity. Charge neutrality is assumed near the peak of the ionosphere, however difference exists between INMS total ion densities and RPWS-LP electron densities and it becomes more noticeable at high solar activity. This may be for several reasons including enhanced negative ion densities and increased electron recombination rates. The model results agree reasonably well with the in-situ measurements for most ion species at low and high solar activity conditions although overproduction exists for some ions (e.g. HCNH+) and underproduction is seen for some heavier species such as C7H7+.

  15. No Outbreak of Vancomycin and Linezolid Resistance in Staphylococcal Pneumonia over a 10-Year Period

    PubMed Central

    Yayan, Josef; Ghebremedhin, Beniam; Rasche, Kurt

    2015-01-01

    Background Staphylococci can cause wound infections and community- and nosocomial-acquired pneumonia, among a range of illnesses. Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) have been rapidly increasing as a cause of infections worldwide in recent decades. Numerous reports indicate that S. aureus and MRSA are becoming resistant to many antibiotics, which makes them very dangerous. Therefore, this study retrospectively investigated the resistance to antimicrobial agents in all hospitalized patients suffering from community- or nosocomial-acquired pneumonia due to S. aureus and MRSA. Methods Information from the study groups suffering from either community- or nosocomial-acquired pneumonia caused by S. aureus or MRSA was gathered by searching records from 2004 to 2014 at the HELIOS Clinic Wuppertal, Witten/Herdecke University, Germany. The findings of antibiotic resistance were analyzed after the evaluation of susceptibility testing for S. aureus and MRSA. Results Total of 147 patients (63.9%, 95% CI 57.5%–69.8%), mean age 67.9 ± 18.5 years, with pneumonia triggered by S. aureus, and 83 patients (36.1%, 95% CI 30.2%–42.5%), mean age 72.3 ± 13.8 years, with pneumonia due to MRSA. S. aureus and MRSA developed no resistance to vancomycin (P = 0.019 vs. < 0.0001, respectively) or linezolid (P = 0.342 vs. < 0.0001, respectively). MRSA (95.3%) and S. aureus (56.3%) showed a high resistance to penicillin. MRSA (87.7%) was also found to have a high antibiotic resistance against ß-lactam antibiotics, compared to S. aureus (9.6%). Furthermore, MRSA compared to S. aureus, respectively, had increased antibiotic resistance to ciprofloxacin (90.1% vs. 17.0%), cefazolin (89.7% vs. 10.2%), cefuroxime (89.0% vs. 9.1%), levofloxacin (88.2% vs. 18.4%), clindamycin (78.0% vs. 14.7%), and erythromycin (76.5% vs. 20.8%). Conclusion No development of resistance was found to vancomycin and linezolid in patients with pneumonia caused by S. aureus and MRSA. PMID:26398276

  16. Forest site preparation effects on Georgia Piedmont soils over a 10-year period

    Treesearch

    James H. Miller; M.B. Edwards

    1997-01-01

    More than a quarter-million acres of forest lands in the Southeast are site prepared annually using mechanical treatments with little to no information on long-term soil sustainability outcomes. The objectives of this rcscarch was to gain a first-view of the soil changes after the following integrated site preparation (SP) treatments: none (cheek), chainsaw felling,...

  17. Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children over a period of 10 years.

    PubMed

    Boyanova, Lyudmila; Lazarova, Elena; Jelev, Christo; Gergova, Galina; Mitov, Ivan

    2007-08-01

    The aims of the study were to evaluate the incidence of Helicobacter pylori and Helicobacter heilmannii in untreated Bulgarian children from 1996 to 2006, to analyse the performance of diagnostic tests, and to look at H. pylori density in specimens by culture. Antral specimens from children with chronic gastritis (n=513), peptic ulcers (n=54) and other diseases (n=91) were evaluated by direct Gram staining (DGS), in-house rapid urease test (RUT) and culture. The living environment and semi-quantitative H. pylori density were assessed in 188 and 328 children, respectively. H. pylori infection was found in children with ulcers (77.8 %), chronic gastritis (64.5 %) and other diseases (36.3 %). Half (51.4 %) of patients aged 1-5 years and 77.4 % of those aged 16-17 years were H. pylori-positive. Of all children, 328 (49.8 %) showed positive DGS, 184 (28 %) had a positive RUT, and 386 (58.7 %) were culture-positive. Unlike gastric mucus specimens, frozen biopsy specimens provided reliable diagnosis. H. heilmannii was observed in two (0.3 %) children. High H. pylori density (growth into all quadrants of plates) was found in 18 % of 328 children evaluated, involving 31 % of ulcer and 16.7 % of non-ulcer patients. H. pylori infection was more common in rural children with chronic gastritis (91.3 %) than in the remainder (66.7 %). In conclusion, H. pylori infection was common in symptomatic Bulgarian children. The infection prevalence was >77 % in patients aged 16-17 years, in children with a duodenal ulcer, and in rural patients. H. heilmannii infection was uncommon. The performance of the bacterial culture was good. The impact of H. pylori density on the clinical expression and eradication of the infection requires further evaluation. The results highlight the need for routine H. pylori diagnosis in rural children with chronic gastritis.

  18. Reconstruction of mandibular defects - clinical retrospective research over a 10-year period -

    PubMed Central

    2011-01-01

    Backround Functional and cosmetic defects in the maxillofacial region are caused by various ailments and these defects are addressed according to their need. Simplicity of procedure, intact facial function and esthetic outcome with the least possible donor site morbidity are the minimum requirements of a good reconstruction. Oro-mandibular reconstruction, although a challenge for the head and neck reconstructive surgeon, is now reliable and highly successful with excellent long-term functional and aesthetic outcomes with the use of autogenous bone grafts. Reconstruction of trauma- or mandibular oncologic defects with bony free flaps is considered the gold standard. However the the optimal reconstruction of mandibular defects is still controversial in regards to reconstructive options which include the donor site selection and the timing of surgery. The purpose of this study was to determine the outcome of different osseous reconstruction options using autogenous bone grafts for mandibular reconstructions. Methods This study was carried out on 178 patients with mandibular bone defects. They were reconstructed with autogenous bone grafts from different donor sites. At post operative visits they were evaluated for functional and cosmetic results. Results The success rate found in this study was around 90%. Only 7.6% of the cases showed poor results regarding facial contours and mouth opening. All other patients were satisfied with their cosmesis and mouth opening at the recipient sites was in the normal range during last follow-up visits. Donor sites were primarily closed in all cases and there was no hypertrophic scar. Conclusion Based on this study, autogenous bone grafts are a reliable treatment modality for the reconstruction of mandibular bone defects with predictable aesthetic and functional outcomes. As the free vascularized fibular flap has the least resorption and failure rate, it should be the first choice for most cases of mandiblular reconstruction. PMID:21527038

  19. Scientific productivity of OECD countries in dermatology journals within the last 10-year period.

    PubMed

    Tasli, Levent; Kacar, Nida; Aydemir, Ertugrul H

    2012-06-01

      Scientific productivity is closely related to gross income, population, and cultures of the countries. Every country, more or less, has a responsibility of contributing to science. The publications, citations received, and the h-index under the category of "dermatology" in 43 journals between the years of 1999-2003 and 2004-2008 according to the ISI JCR data of 2008 were examined individually for each OECD country. In the journals under the category of "dermatology" between the years of 1999 and 2008, there were 89,319 publications, 76,899 of which were published by OECD countries. USA ranks first with 27,109 publications and 196,002 citations; Germany, Japan, England, and France are the other countries among the top five, respectively. Regarding the number of publications, Turkey and Korea are among the top 10 by surpassing many Northern European countries. With regard to h-index and citations, Northern European countries and Canada rank among the top 10, while Japan, Spain, Turkey, and Korea rank behind. The number of publications showed a significant correlation with the number of citations, population, gross domestic product, and h-index.   Nearly half of all publications were performed by the European origin OECD countries, and one-third of all publications were performed by USA. Journals from Germany and France, which are published in their own language, receive fewer citations, but they contribute a lot to these countries with respect to the number of publications. © 2012 The International Society of Dermatology.

  20. Types and frequency of ovarian masses in children over a 10-year period.

    PubMed

    Sadeghian, Naser; Sadeghian, Irandokht; Mirshemirani, Alireza; Khaleghnejad Tabari, Ahmad; Ghoroubi, Javad; Abdollah Gorji, Fatemeh; Roushanzamir, Fatollah

    2015-01-01

    Ovarian masses represent a range of pathology from benign cyst to highly aggressive malignant tumors. It has been estimated that gynecologic malignancy account for approximately 2% of all types of cancer in children, 60-70% of these lesions arise in the ovary. All ovarian masses which were resected or biopsied in Mofid Children's Hospital from 2002 to 2012 were reviewed retrospectively. Patient's age, presenting symptoms, surgical procedures, pathological diagnosis, postoperative treatment, and outcome were obtained from medical records. Fifty-seven girls (aged 40.2±57months with the range of 1 day to 15 years) underwent different types of ovarian operations (24 salpingo-oophorectomies, 10 oophorectomies, 21 ovarian cystectomies, and 2 ovarian biopsies). 50 children had unilateral ovarian mass (49.1% right and 38.6 left, respectively). The most common presenting symptoms were acute abdominal pain in 46%.Twenty one (37%) of our patients had ovarian torsion. Four (7%) patients had benign tumors, and 8 (14%) had malignant tumors. There were no age differences between those with benign type (8.2±2.6years) and malignant tumors (6.1±5.3years) (P=0.683). Ovarian tumors are rare in children. Most are benign, in children presenting with acute abdominal pain, ovarian mass particularly neoplastic tumors should be suspected. An important proportion of these patients may require postoperative chemotherapy.

  1. Predictors of parenting concern in a Mother and Baby Unit over a 10-year period.

    PubMed

    Whitmore, Jennifer; Heron, Jessica; Wainscott, Gillian

    2011-09-01

    To review the characteristics of 462 mothers consecutively admitted to a co-joined mother and baby unit and to examine the incidence and predictors of social services input and separate discharge. Admissions to the Birmingham Mother and Baby Unit from 1998 to 2007 were reviewed. Demographic and clinical information, social services involvement and parenting outcome data were collected from case notes and computerized records. One hundred and forty six (146) women received some form of social services input (32%); 44 cases of separate discharge were identified (10%). Diagnosis, involuntary admission, single status, younger age, Afro-Caribbean ethnicity and social services referral predicted parenting concern. Only 9% of separations were to women suffering a new postpartum mental illness; most were to women experiencing the continuation of an existing illness. Poor parenting skills, absence of a good partner relationship and alcohol/substance misuse were frequently reported in those discharged without their baby. The incidence of separate discharge is lower than in other studies. Potential reasons for this difference are discussed. Further work must be conducted to understand the social inequities and regional differences in social service intervention during perinatal psychiatric admission and determine if parenting outcomes can be improved in women at risk of separation.

  2. The cost effectiveness of tacrolimus versus microemulsified cyclosporin: a 10-year model of renal transplantation outcomes.

    PubMed

    Orme, Michelle E; Jurewicz, Wieslaw A; Kumar, Nagappan; McKechnie, Tracy L

    2003-01-01

    In 1983, the launch of cyclosporin was a significant clinical advance for organ transplant recipients. Subsequent drug research led to further advances with the introduction of cyclosporin microemulsion (cyclosporin ME) and tacrolimus. This paper presents the results from a long-term model comparing the clinical and economic outcomes associated with cyclosporin ME and tacrolimus immunosuppression for the prevention of graft rejection following renal transplantation. A model was developed to project the costs and outcomes over a 10-year period following transplantation. The model was based on the results of a prospective, randomised study of 179 renal transplantation recipients receiving either cyclosporin ME or tacrolimus, which was conducted by the Welsh Transplantation Research Group (median follow-up: 2.7 years). The short-term costs and outcomes were the averages from the actual head-to-head trial data. From this, the long-term costs and outcomes were extrapolated based on the rate of change in patient and graft survival at 3, 5 and 10 years post transplant, as reported in the 1995 United Kingdom Transplant Support Service Authority Renal Transplant Audit. PERSPECTIVE AND YEAR OF COST DATA: The analysis was conducted from the perspective of a UK transplant unit. Costs were at 1999 prices (pounds sterling 1 = dollars US 1.42 = Euro 1.5) and costs and outcomes were discounted at 6% and 1.5%, respectively. The model estimated that 10 years after transplantation, the proportion of patients surviving was 56% of the cyclosporin ME cohort and 64% of the tacrolimus cohort. The cumulative cost of maintenance therapy at 10 years was pounds sterling 23204 per patient maintained on cyclosporin ME versus pounds sterling 23803 per patient on tacrolimus. The cost per survivor at 10 years was pounds sterling 37000 (tacrolimus) versus pounds sterling 41000 (cyclosporin ME) and the cost per patient with a functioning graft was pounds sterling 39000 versus pounds sterling 45000

  3. Volumetric growth analysis of an insular dysembryoplastic neuroepithelial tumor over a 10-year follow-up

    PubMed Central

    Uno, Takehiro; Kinoshita, Masashi; Furuta, Takuya; Miyashita, Katsuyoshi; Sabit, Hemragul; Nakada, Mitsutoshi

    2016-01-01

    Background: Dysembryoplastic neuroepithelial tumors (DNETs) are benign tumors characterized by a cortical location; they result in symptoms of drug-resistant partial seizures in children. The development of DNETs is poorly understood because most of them are resected immediately upon diagnosis without any observation period owing to the intractable seizures. Case Description: We report the first DNET case with the growth rate analyzed in the natural course of development for a period of 10 years. The patient was a right-handed man who was initially referred to another hospital with mild head injury when he was 8 years old. A tumor located in the right insular cortex was incidentally detected on magnetic resonance imaging (MRI) and followed-up with annual MRI for 10 years. Conclusion: In this case, the volume of the DNET increased in direct proportion to the length of time in its clinical course. The tumor doubling time was approximately 10 years. This case suggests DNET is a slow-growing but not stable tumor. PMID:28194304

  4. Reconstructive surgery after burns: a 10-year follow-up study.

    PubMed

    Hop, M J; Langenberg, L C; Hiddingh, J; Stekelenburg, C M; van der Wal, M B A; Hoogewerf, C J; van Koppen, M L J; Polinder, S; van Zuijlen, P P M; van Baar, M E; Middelkoop, E

    2014-12-01

    There is minimal insight into the prevalence of reconstructive surgery after burns. The objective of this study was to analyse the prevalence, predictors, indications, techniques and medical costs of reconstructive surgery after burns. A retrospective cohort study was conducted in the three Dutch burn centres. Patients with acute burns, admitted from January 1998 until December 2001, were included. Data on patient and injury characteristics and reconstructive surgery details were collected in a 10-year follow-up period. In 13.0% (n=229/1768) of the patients with burns, reconstructive surgery was performed during the 10-year follow-up period. Mean number of reconstructive procedure per patient were 3.6 (range 1-25). Frequently reconstructed locations were hands and head/neck. The most important indication was scar contracture and the most applied technique was release plus random flaps/skin grafting. Mean medical costs of reconstructive surgery per patient over 10-years were €8342. With this study we elucidated the reconstructive needs of patients after burns. The data presented can be used as reference in future studies that aim to improve scar quality of burns and decrease the need for reconstructive surgery. Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.

  5. ESO and Chile: 10 Years of Productive Scientific Collaboration

    NASA Astrophysics Data System (ADS)

    2006-06-01

    ESO and the Government of Chile launched today the book "10 Years Exploring the Universe", written by the beneficiaries of the ESO-Chile Joint Committee. This annual fund provides grants for individual Chilean scientists, research infrastructures, scientific congresses, workshops for science teachers and astronomy outreach programmes for the public. In a ceremony held in Santiago on 19 June 2006, the European Organisation for Astronomical Research in the Southern Hemisphere (ESO) and the Chilean Ministry of Foreign Affairs marked the 10th Anniversary of the Supplementary Agreement, which granted to Chilean astronomers up to 10 percent of the total observing time on ESO telescopes. This agreement also established an annual fund for the development of astronomy, managed by the so-called "ESO-Chile Joint Committee". ESO PR Photo 21/06 ESO PR Photo 21/06 Ten Years ESO-Chile Agreement Ceremony The celebration event was hosted by ESO Director General, Dr. Catherine Cesarsky, and the Director of Special Policy for the Chilean Ministry of Foreign Affairs, Ambassador Luis Winter. "ESO's commitment is, and always will be, to promote astronomy and scientific knowledge in the country hosting our observatories", said ESO Director General, Dr. Catherine Cesarsky. "We hope Chile and Europe will continue with great achievements in this fascinating joint adventure, the exploration of the universe." On behalf of the Government of Chile, Ambassador Luis Winter outlined the historical importance of the Supplementary Agreement, ratified by the Chilean Congress in 1996. "Such is the magnitude of ESO-Chile Joint Committee that, only in 2005, this annual fund represented 8 percent of all financing sources for Chilean astronomy, including those from Government and universities", Ambassador Winter said. The ESO Representative and Head of Science in Chile, Dr. Felix Mirabel, and the appointed Chilean astronomer for the ESO-Chile Joint Committee, Dr. Leonardo Bronfman, also took part in the

  6. METEONETWORK: 2002-2012, 10 years of activities

    NASA Astrophysics Data System (ADS)

    Mazza, Edoardo

    2013-04-01

    The role of citizen-scientists in collecting data and observations has been increasingly crucial in the last 10 years of atmospheric sciences. Meteonetwork is a non-profit organization founded by citizen scientists in 2002, in Lombardia, with the aim of raising public awareness about meteorological and climatological issues. Throughout the years the organization, besides the continuous holding of events such as meeting, conferences and talks, has been standing out because of its forum and its wide network of weather stations. Meteonetwork's forum is, in this field, the most read and followed in the country and with its 8459 members and over 4,217,505 posts turns out to be the 17th forum over the entire country. Its network is operated in cooperation with Centro Epson Meteo and collects amateur semi-professional stations distributed all over the Italian territory, providing real-time and daily data. It consists of 706 stations, among which more than 400 regularly updated; volunteers constantly work to perform quality control and ensure data reliability. Meteonetwork has also developed several collaborations with private and public institutions, among which DRIHM - Cima Research Foundation, Centro Epson Meteo di Milano, Arpa Veneto, Arpa Emilia-Romagna, Arpa Lombardia, Arpa Friuli - Venezia Giulia, Servizio Glaciologico Lombardo, C. N. R. - C. I. S. A, Università di Pisa, Università di Milano, University of Aberdeen, Protezione Civile - Regione Lombardia, Protezione Civile - Regione Piemonte stand out. As WMO emphasized in 2001 World Meteorological Day "Volunteers for the weather, climate and water" the contribution of citizen-scientists to scientific studies is remarkable. In this perspective Meteonetwork and the University of Milan, in April 2011, started a project of technical and scientific cooperation called Weatherness. The university is provided with data gathered by Meteoneonetwork's stations with the aim of improving the knowledge of the impact that heat

  7. Radicular Perforation Repair with Mineral Trioxide Aggregate: A Case Report with 10-Year Follow-up

    PubMed Central

    Cosme-Silva, Leopoldo; Carnevalli, Breno; Sakai, Vivien Thiemy; Viola, Naiana Viana; Franco de Carvalho, Leon; Franco de Carvalho, Elaine Manso Oliveira

    2016-01-01

    Background: Iatrogenic complications such as accidental perforation of the root or the floor of the pulp chamber may occur. Case Report: Patient was referred for root canal retreatment of the mandibular left second molar with periapical lesion evidenced through radiographic examination. During post removal, iatrogenic perforation occurred at the mesial face of the distal root. After clinical localization of the perforation and bleeding control, MTA was applied. In a second appointment, the root canal filling was removed and the chemical-surgical retreatment of the canals was performed, followed by the obturation with gutta-percha and sealer. Patient returned after three days reporting no pain. After 6 months, 3, 7 and 10 years of follow-up. Conclusion: Absence of pain, normal periodontal probing and lack of radiolucent area at the region of perforation and the periapices were detected, which evidenced the successful repair of the tooth. PMID:28217189

  8. Subsequent fracture rates in a nationwide population-based cohort study with a 10-year perspective.

    PubMed

    Hansen, L; Petersen, K D; Eriksen, S A; Langdahl, B L; Eiken, P A; Brixen, K; Abrahamsen, B; Jensen, J-E B; Harsløf, T; Vestergaard, P

    2015-02-01

    Fractures after the age of 50 are frequently observed in Denmark, and many of these may be osteoporotic. This study examined the incidence of all and subsequent fractures in a 10-year period from 2001 to 2011. The incidence of subsequent fractures was high, especially following hip fracture. The purpose of this study is to examine patterns of subsequent fractures and mortality rates over a 10-year period in patients already suffering from fracture. The study was designed as a nationwide, register-based follow-up study. Patients were included if diagnosed with an index fracture (ICD-10 codes: S22.x, S32.x, S42.x, S52.x, S62.x, S72.x, S82.x, S92.x, T02.x, T08.x, T10.x and T12.x) between January 1st, 2001 and December 31st, 2001 and if older than 50 years at time of fracture. The patients were investigated for future subsequent fractures from January 1st, 2002 to December 31st, 2011. In this study, we demonstrated that patients with fractures (especially hip fractures) have a high risk of subsequent fractures, especially hip fracture. Other fractures, which are not commonly considered as osteoporotic fractures, such as lower leg, were frequently observed in the 10 years following index fracture. The cumulative incidence proportion (CIP) of subsequent fractures during the 10-year follow-up period was high for all recurrent fractures (9-46 %). Subsequent hip fracture, regardless of index fracture, had the highest CIP across the study period, ranging from 9 to 40 %. Appendicular fractures were often followed by a recurrent fracture, or subsequent fractures at a more proximal location in the same limb, i.e. forearm fractures were followed by humerus fractures. These results have not been previously demonstrated to this extent, and according to our knowledge, no previous studies have estimated cumulative 10-year subsequent fracture incidences for any non-hip fractures. Patients suffering a fracture (and especially a hip fracture) have a high incidence of subsequent

  9. Physical aggression, compromised social support, and 10-year marital outcomes: Testing a relational spillover model.

    PubMed

    Sullivan, Kieran T; Pasch, Lauri A; Lawrence, Erika; Bradbury, Thomas N

    2015-12-01

    The purpose of the present study was to test a relational spillover model of physical aggression whereby physical aggression affects marital outcomes due to its effects on how spouses ask for and provide support to one another. Newlywed couples (n = 172) reported levels of physical aggression over the past year and engaged in interactions designed to elicit social support; marital adjustment, and stability were assessed periodically over the first 10 years of marriage. Multilevel modeling revealed that negative support behavior mediated the relationship between physical aggression and 10-year marital adjustment levels whereas positive support behavior mediated the relationship between physical aggression and divorce status. These findings emphasize the need to look beyond conflict when explaining how aggression affects relationships and when working with couples with a history of physical aggression who are seeking to improve their relationships.

  10. Rugby injuries to the cervical spine and spinal cord: a 10-year review.

    PubMed

    Scher, A T

    1998-01-01

    A 10-year review (1987-1996) of injuries sustained to the spine and spinal cord in rugby players with resultant paralysis has been undertaken. This article reviews that the incidence of serious rugby spine and spinal cord injuries in South Africa has increased over the 10-year period reviewed, despite stringent new rules instituted in an attempt to decrease the incidence of these injuries. The mechanisms of injury, as previously reported, remain the same as well as the phases of game responsible for injury of the tight scrum, tackle, rucks, and mauls. Two new observations are reported: the first is related to the occurrence of spinal cord concussion with transient paralysis, and the second is related to the increased incidence of osteoarthritis of the cervical spine in rugby players.

  11. Stress Generation, Avoidance Coping, and Depressive Symptoms: A 10-Year Model

    PubMed Central

    Holahan, Charles J.; Moos, Rudolf H.; Holahan, Carole K.; Brennan, Penny L.; Schutte, Kathleen K.

    2011-01-01

    This study examined (a) the role of avoidance coping in prospectively generating both chronic and acute life stressors and (b) the stress-generating role of avoidance coping as a prospective link to future depressive symptoms. Participants were 1,211 late-middle-aged individuals (500 women and 711 men) assessed 3 times over a 10-year period. As predicted, baseline avoidance coping was prospectively associated with both more chronic and more acute life stressors 4 years later. Furthermore, as predicted, these intervening life stressors linked baseline avoidance coping and depressive symptoms 10 years later, controlling for the influence of initial depressive symptoms. These findings broaden knowledge about the stress-generation process and elucidate a key mechanism through which avoidance coping is linked to depressive symptoms. PMID:16173853

  12. Establishing a children's orthopaedic hospital for Malawi: A review after 10 years.

    PubMed

    Dorman, S L; Graham, S M; Paniker, J; Phalira, S; Harrison, W J

    2014-12-01

    BEIT CURE International Hospital (BCIH) opened in 2002 providing orthopaedic surgical services to children in Malawi. This study reviews the hospital's progress 10 years after establishment of operational services. In addition we assess the impact of the hospital's Malawi national clubfoot programme (MNCP) and influence on orthopaedic training. All operative paediatric procedures performed by BCIH services in the 10th operative year were included. Data on clubfoot clinic locations and number of patients treated were obtained from the MNCP. BCIH records were reviewed to identify the number of healthcare professionals who have received training at the BCIH. 609 new patients were operated on in the 10th year of hospital service. Patients were treated from all regions; however 60% came from Southern regions compared with the 48% in the 5th year. Clubfoot, burn contracture and angular lower limb deformities were the three most common pathologies treated surgically. In total BCIH managed 9,842 patients surgically over a 10-year period. BCIH helped to establish and co-ordinate the MNCP since 2007. At present the program has a total of 29 clinics, which have treated 5748 patients. Furthermore, BCIH has overseen the full or partial training of 5 orthopaedic surgeons and 82 orthopaedic clinical officers in Malawi. The BCIH has improved the care of paediatric patients in a country that prior to its establishment had no dedicated paediatric orthopaedic service, treating almost 10,000 patients surgically and 6,000 patients in the MNCP. This service has remained consistent over a 10-year period despite times of global austerity. Whilst the type of training placement offered at BCIH has changed in the last 10 years, the priority placed on training has remained paramount. The strategic impact of long-term training commitments are now being realised, in particular by the addition of Orthopaedic surgeons serving the nation.

  13. Alopecia Areata in the Elderly: A 10-Year Retrospective Study

    PubMed Central

    Jang, Yong Hyun; Park, Kyung Hea; Kim, Sang Lim; Lim, Hyun Jung; Lee, Weon Ju; Lee, Seok-Jong

    2015-01-01

    Background Alopecia areata (AA) is an organ-specific autoimmune disease that typically occurs in young adults. AA in the elderly is relatively rare, thus little data have been reported. Objective This study aimed to understand the clinical characteristics of AA in the elderly. Methods We performed a 10-year retrospective study of AA in the elderly who visited our dermatologic clinic from January 2002 to December 2011. A clinical review of medical records and telephone interviews were performed by two dermatologists. Results Among 1,761 patients with newly diagnosed AA, 61 (3.5%) were older than 60 years at the first visit. Among those who completed a telephone interview, 74.3% (26/35) had less than 50% of scalp-localized hair loss. There was no association between the extent of AA and hair graying (p=0.679). Favorable therapeutic response was observed in 62.9% (22/35) of cases. Conclusion AA in the elderly shows mild disease severity and favorable treatment response. There is no association between graying and the extent of AA. However, the influence of aging on the pathogenesis of AA in the elderly deserves further investigation. PMID:26273157

  14. Dissociative recombination of H3+: 10 years in retrospect

    PubMed Central

    Larsson, Mats

    2012-01-01

    The dissociative recombination of has been an intriguing problem for more than half a century. The early experiments on during the first 20 years were carried out without mass analysis in decaying plasma afterglows, and thus the measured rates pertained to an uncontrolled mixture of and impurity ions. When mass analysis was used, the rate coefficient was determined to be an uneventful value of about 10−7 cm3 s−1, a very common rate coefficient for many molecular ions. But this was not the end of the story, not even the beginning of the end; it marked only the end of the beginning. The story I will tell in this article started about 10 years ago, when the dissociative recombination of was approaching its deepest crisis. Today, owing to an extensive experimental and theoretical effort, the state of affairs has reached a historically unique level of harmony, although there still remains many things to sort out. PMID:23028159

  15. ß cell replacement therapy: the next 10 years.

    PubMed

    Schuetz, Christian; Anazawa, Takayuki; Cross, Sarah E; Labriola, Leticia; Meier, Raphael P H; Redfield, Robert R; Scholz, Hanne; Stock, Peter G; Zammit, Nathan W

    2017-09-06

    ß cell replacement with either pancreas or islet transplantation has progressed immensely over the last decades with current 1- and 5-year insulin independence rates of ~85% and ~50%, respectively. Recent advances are largely attributed to improvements in immunosuppressive regimen, donor selection and surgical technique. However, both strategies are compromised by a scarce donor source. Xenotransplantation provides a potential solution by providing a theoretically unlimited supply of islets, but clinical application has been limited by concerns for a potent immune response against xenogeneic tissue. ß cell clusters derived from embryonic or induced pluripotent stem (iPS) cells represent another promising unlimited source of insulin producing cells, but clinical application is pending further advances in the function of the ß cell like clusters. Exciting developments and rapid progress in all areas of ß cell replacement prompted a lively debate by members of the young investigator committee of the International Pancreas and Islet Transplant Association (IPITA) at the 15th IPITA Congress in Melbourne and at the 26th international congress of The Transplant Society (TTS) in Hong Kong. This international group of young investigators debated which modality of ß cell replacement would predominate the landscape in 10 years, and their arguments are summarized here.

  16. Prospective Analysis of Hip Arthroscopy with 10-year Followup

    PubMed Central

    Jones, Kay S.

    2009-01-01

    Arthroscopic surgery of the hip is a well-established technique with numerous recognized indications. Despite the well-accepted nature of this procedure, there have been no outcomes studies with extended followup. We investigated the response to hip arthroscopy in a consecutive series of patients with 10 years followup. Since 1993, all patients undergoing hip arthroscopy have been assessed prospectively with a modified Harris hip score preoperatively and then postoperatively at 3, 12, 24, 60, and 120 months. A cohort of 50 patients (52 hips) was identified who had achieved 10-year followup and represent the substance of this study. There was 100% followup. The average age of the patients was 38 years (range, 14–84 years), with 27 males and 23 females. The median improvement was 25 points (preoperative, 56 points; postoperative, 81 points). Fourteen patients were converted to THA and two died. Four patients underwent repeat arthroscopy. There were two complications in one patient. The presence of arthritis at the time of the index procedure was an indicator of poor prognosis. This study substantiates the long-term effectiveness of arthroscopy in the hip as treatment for various disorders, including labral pathology, chondral damage, synovitis, and loose bodies. Arthritis is an indicator of poor long-term outcomes with these reported methods. Level of Evidence: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence. PMID:19381742

  17. Language Disorders: A 10-Year Research Update Review

    PubMed Central

    TOPPELBERG, CLAUDIO O.; SHAPIRO, THEODORE

    2012-01-01

    Objective To review the past 10 years of research in child language or communication disorders, which are highly prevalent in the general population and comorbid with childhood psychiatric disorders. Method A literature search of 3 major databases was conducted. The child language literature, describing the domains of language development—phonology, grammar, semantics, and pragmatics—is reviewed. Results Disorders of grammar, semantics, and pragmatics, but not phonology, overlap significantly with childhood psychiatric disorders. Receptive language disorders have emerged as high-risk indicators, often undiagnosed. Language disorders and delays are psychiatric risk factors and have implications for evaluation, therapy, and research. However, they are often undiagnosed in child mental health and community settings. The research has focused mostly on monolingual English-speaking children. Conclusion Awareness of basic child language development, delay, and deviance is crucial for the practicing child and adolescent psychiatrist, who must diagnose and refer relevant cases for treatment and remediation. Future research needs to address the growing language diversity of our clinical populations. PMID:10673823

  18. Proteasome inhibitors in multiple myeloma: 10 years later

    PubMed Central

    Richardson, Paul G.; Cavo, Michele; Orlowski, Robert Z.; San Miguel, Jesús F.; Palumbo, Antonio; Harousseau, Jean-Luc

    2012-01-01

    Proteasome inhibition has emerged as an important therapeutic strategy in multiple myeloma (MM). Since the publication of the first phase 1 trials of bortezomib 10 years ago, this first-in-class proteasome inhibitor (PI) has contributed substantially to the observed improvement in survival in MM patients over the past decade. Although first approved as a single agent in the relapsed setting, bortezomib is now predominantly used in combination regimens. Furthermore, the standard twice-weekly schedule may be replaced by weekly infusion, especially when bortezomib is used as part of combination regimens in frontline therapy. Indeed, bortezomib is an established component of induction therapy for patients eligible or ineligible for autologous stem cell transplantation. Bortezomib has also been incorporated into conditioning regimens before autologous stem cell transplantation, as well as into post-ASCT consolidation therapy, and in the maintenance setting. In addition, a new route of bortezomib administration, subcutaneous infusion, has recently been approved. Recently, several new agents have been introduced into the clinic, including carfilzomib, marizomib, and MLN9708, and trials investigating these “second-generation” PIs in patients with relapsed/refractory MMs have demonstrated positive results. This review provides an overview of the role of PIs in the treatment of MM, focusing on developments over the past decade. PMID:22645181

  19. 10 Years of Student Questions about the Radiation Belts

    NASA Astrophysics Data System (ADS)

    Gross, N. A.; Hughes, W. J.; Wiltberger, M. J.

    2016-12-01

    The NSF funded CISM Space Weather Summer School is targeted to graduate students just starting in space physics and provides a comprehensive conceptual background to the field. Insights from this summer school can provide valuable information to graduate instructors and graduate student mentors. During the school, students are invited to submit questions at the end of the lecture component each day. The lecturers then take the time to respond to these questions. We have collected over 3000 student questions over the last 10 years. The radiation belts, solar energetic particles, and the operational impacts of high energy particles are among the topics covered during the summer school, and these topics consistently generate a share of the questions following those lectures. The collection includes questions about: the structure and variability of the radiation belts, the distinction between solar energetic particles (SEPs) and the radiation belts, the distinction between the ring current and the radiation belts, the impact radiation belt particles and SEPs have on the magnetosphere, the risks high energy particles pose to spacecraft and humans, their impact on operations, regulations for human exposure, and others. The presentation will catalog the questions asked by students and provide insight into students prior conceptions and misunderstandings about this topic. We hope this work informs instructors who teach these topics.

  20. Oral squamous cell carcinoma in a 10 year old boy.

    PubMed

    Khan, M H; Naushad, Q N

    2011-01-01

    Squamous cell carcinoma of the oral cavity a type of Oral Cancer in young patients is a very rare occurrence particularly during the first decade of life. Oral cancer is predominantly an aggressive neoplasm of middle-aged people where 96% of the patients are more than 40 years of age and it occurs mainly due to the excessive consumption of tobacco and alcohol. In South-East Asia it has a higher rate of occurrence than the rest of the world, partly due to increased consumption of chewing tobacco and various harmful spices, areca nuts and betel quids. These rare varieties of aggressive neoplasm commonly affect tongue and lip. This report describes a case of squamous cell carcinoma in a 10 year old boy who had an exophytic type of granulomatous lesion with some indurated borders which diffusely involved the left side of the hard palate, alveolar mucosa, left maxillary antrum and aggressively emerged within the left orbit by engulfing the left inferior rectus muscle. The purpose of this case report is to provide information that younger group can suffer from oral squamous cell carcinoma though it is very rare and this younger group would appear to have a biologically more aggressive tumor and they require more complex treatment. The role of more aggressive initial therapy must be considered.

  1. Improving mortality data in Jordan: a 10 year review

    PubMed Central

    Dababneh, Faris; Asad, Majed; Haddad, Yousef; Notzon, Francis; Anderson, Robert

    2015-01-01

    Abstract Problem Before 2003 there was substantial underreporting of deaths in Jordan. The death notification form did not comply with World Health Organization (WHO) guidelines and information on the cause of death was often missing, incomplete or inaccurate. Approach A new mortality surveillance system to determine the causes of death was implemented in 2003 and a unit for coding causes of death was established at the ministry of health. Local setting Jordan is a middle-income country with a population of 6.4 million people. Approximately 20 000 deaths were registered per year between 2005 and 2011. Relevant changes In 2001, the ministry of health organized the first meeting on Jordan’s mortality system, which yielded a five-point plan to improve mortality statistics. Using the recommendations produced from this meeting, in 2003 the ministry of health initiated a mortality statistics improvement project in collaboration with international partners. Jordan has continued to improve its mortality reporting system, with annual reporting since 2004. Reports are based on more than 70% of reported deaths. The quality of cause-of-death information has improved, with only about 6% of deaths allocated to symptoms and ill-defined conditions – a substantial decrease from the percentage before 2001 (40%). Mortality information is now submitted to WHO following international standards. Lessons learnt After 10 years of mortality surveillance in Jordan, the reporting has improved and the information has been used by various health programmes throughout Jordan. PMID:26600615

  2. 26 CFR 156.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., assessment and collection of the penalties under section 6694(a) and (b), the rules under § 1.6694-4 of this chapter will apply. (b) Effective/applicability date. This section is applicable to returns and claims for...

  3. 26 CFR 54.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... understatement of taxpayer's liability, and procedural matters relating to the investigation, assessment and... apply. (b) Effective/applicability date. This section is applicable to returns and claims for refund...

  4. 26 CFR 31.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... understatement of taxpayer's liability and procedural matters relating to the investigation, assessment and... apply. (b) Effective/applicability date. This section is applicable to returns and claims for refund...

  5. 26 CFR 56.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., assessment and collection of the penalties under section 6694(a) and (b), the rules under § 1.6694-4 of this chapter will apply. (b) Effective/applicability date. This section is applicable to returns and claims for...

  6. 26 CFR 55.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... taxpayer's liability and procedural matters relating to the investigation, assessment and collection of the...) Effective/applicability date. This section is applicable to returns and claims for refund filed, and advice...

  7. Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study.

    PubMed

    Tomany, Sandra C; Cruickshanks, Karen J; Klein, Ronald; Klein, Barbara E K; Knudtson, Michael D

    2004-05-01

    To examine the association of sunlight exposure and indicators of sun sensitivity with the 10-year incidence of age-related maculopathy (ARM). Population-based cohort study. We included persons aged 43 to 86 years at the baseline examination from 1988 to 1990, living in Beaver Dam, Wis, of whom 3684 persons underwent 5-year follow-up and 2764 underwent 10-year follow-up. Data on sun exposure and indicators of sun sensitivity were obtained from a standardized questionnaire administered at baseline and/or follow-up. We determined ARM status by grading stereoscopic color fundus photographs using the Wisconsin Age-Related Maculopathy Grading System. Incidence and progression of ARM. While controlling for age and sex, we found that participants exposed to the summer sun for more than 5 hours a day during their teens, in their 30s, and at the baseline examination were at a higher risk of developing increased retinal pigment (risk ratio [RR], 2.99; 95% confidence interval [CI], 1.18-7.60; P =.02) and early ARM (RR, 2.20; 95% CI, 1.02-4.73; P =.04) [corrected] by 10 years than those exposed less than 2 hours per day during the same periods. In participants reporting the highest summer sun exposure levels in their teens and 30s, the use of hats and sunglasses at least half the time during the same periods was associated with a decreased risk of developing soft indistinct drusen (RR, 0.55; 95% CI, 0.33-0.90; P =.02) and retinal pigment epithelial depigmentation (RR, 0.51; 95% CI, 0.29-0.91; P =.02). Participants who experienced more than 10 severe sunburns during their youth were more likely than those who experienced 1 or no burn to develop drusen with a 250-microm diameter or larger (RR, 2.52; 95% CI, 1.29-4.94 [corrected] P =.01) by the 10-year examination. No relationships were found between UV-B exposure, winter leisure time spent outdoors, skin sun sensitivity, or number of bad sunburns experienced by the time of the baseline examination and the 10-year incidence and

  8. Endometrial stem/progenitor cells: the first 10 years

    PubMed Central

    Gargett, Caroline E.; Schwab, Kjiana E.; Deane, James A.

    2016-01-01

    BACKGROUND The existence of stem/progenitor cells in the endometrium was postulated many years ago, but the first functional evidence was only published in 2004. The identification of rare epithelial and stromal populations of clonogenic cells in human endometrium has opened an active area of research on endometrial stem/progenitor cells in the subsequent 10 years. METHODS The published literature was searched using the PubMed database with the search terms ‘endometrial stem cells and menstrual blood stem cells' until December 2014. RESULTS Endometrial epithelial stem/progenitor cells have been identified as clonogenic cells in human and as label-retaining or CD44+ cells in mouse endometrium, but their characterization has been modest. In contrast, endometrial mesenchymal stem/stromal cells (MSCs) have been well characterized and show similar properties to bone marrow MSCs. Specific markers for their enrichment have been identified, CD146+PDGFRβ+ (platelet-derived growth factor receptor beta) and SUSD2+ (sushi domain containing-2), which detected their perivascular location and likely pericyte identity in endometrial basalis and functionalis vessels. Transcriptomics and secretomics of SUSD2+ cells confirm their perivascular phenotype. Stromal fibroblasts cultured from endometrial tissue or menstrual blood also have some MSC characteristics and demonstrate broad multilineage differentiation potential for mesodermal, endodermal and ectodermal lineages, indicating their plasticity. Side population (SP) cells are a mixed population, although predominantly vascular cells, which exhibit adult stem cell properties, including tissue reconstitution. There is some evidence that bone marrow cells contribute a small population of endometrial epithelial and stromal cells. The discovery of specific markers for endometrial stem/progenitor cells has enabled the examination of their role in endometrial proliferative disorders, including endometriosis, adenomyosis and Asherman

  9. Endometrial stem/progenitor cells: the first 10 years.

    PubMed

    Gargett, Caroline E; Schwab, Kjiana E; Deane, James A

    2016-01-01

    The existence of stem/progenitor cells in the endometrium was postulated many years ago, but the first functional evidence was only published in 2004. The identification of rare epithelial and stromal populations of clonogenic cells in human endometrium has opened an active area of research on endometrial stem/progenitor cells in the subsequent 10 years. The published literature was searched using the PubMed database with the search terms 'endometrial stem cells and menstrual blood stem cells' until December 2014. Endometrial epithelial stem/progenitor cells have been identified as clonogenic cells in human and as label-retaining or CD44(+) cells in mouse endometrium, but their characterization has been modest. In contrast, endometrial mesenchymal stem/stromal cells (MSCs) have been well characterized and show similar properties to bone marrow MSCs. Specific markers for their enrichment have been identified, CD146(+)PDGFRβ(+) (platelet-derived growth factor receptor beta) and SUSD2(+) (sushi domain containing-2), which detected their perivascular location and likely pericyte identity in endometrial basalis and functionalis vessels. Transcriptomics and secretomics of SUSD2(+) cells confirm their perivascular phenotype. Stromal fibroblasts cultured from endometrial tissue or menstrual blood also have some MSC characteristics and demonstrate broad multilineage differentiation potential for mesodermal, endodermal and ectodermal lineages, indicating their plasticity. Side population (SP) cells are a mixed population, although predominantly vascular cells, which exhibit adult stem cell properties, including tissue reconstitution. There is some evidence that bone marrow cells contribute a small population of endometrial epithelial and stromal cells. The discovery of specific markers for endometrial stem/progenitor cells has enabled the examination of their role in endometrial proliferative disorders, including endometriosis, adenomyosis and Asherman's syndrome

  10. "Media addiction" in a 10-year-old boy.

    PubMed

    Brown, Scott; Scharf, Michael A; Bustos, Cristina; Chavira, Denise; Stein, Martin T

    2013-06-01

    Bryan is a 10-year-old boy who is brought to his pediatrician by his parents with concerns about oppositional behaviors. Bryan's parents report that he has always been hyperactive and oppositional since a very young age. He has been previously diagnosed with attention-deficit hyperactivity disorder and has been treated with appropriate stimulant medications for several years; however, despite this, his parents feel increasingly unable to manage his difficult behaviors. He refuses to do chores or follow through with household routines. He refuses to go to bed at night. His family feels unable to take him to public places because he "climbs all over everything." At school, he acts up in class, is often disruptive, and requires close supervision by teachers. He was recently kicked off of the school bus. He has very few friends, and his parents state that other children do not enjoy to be around him. Bryan's parents also report that he is "obsessed" with electronics. He spends most his free time watching TV and movies and playing computer games. He has a television in his bedroom because otherwise he "monopolizes" the family television. The family also owns several portable electronic devices that he frequently uses. Bryan insists on watching TV during meals and even that the TV stays on in an adjacent room while showering. He gets up early each morning and turns on the television. He refuses to leave the house unless he can take a portable screen device with him. His parents admit to difficulty placing limits on this behavior because they feel it is the only way to keep his other behaviors under control. His mother explains "it is our only pacifier" and that attempts to place restrictions are met with explosive tantrums and have thus been short lived. These efforts have also been impeded due to the habits of his parents and older sibling, who also enjoy spending a significant amount of time watching television.

  11. [Cardiac factors predictive of 10-year survival after coronary surgery].

    PubMed

    Fournial, G; Fourcade, J; Roux, D; Garcia, O; Sauer, M; Glock, Y

    1999-07-01

    Although the predictive factors of postoperative mortality after coronary artery surgery are well known, those predictive of long-term survival have received less attention. This study reviews the outcome of a group of 480 patients between 50 and 65 years of age, operated between 1984 and 1986. The patients were classified in two groups according to the presence or absence of internal mammary artery bypass grafts: Group I (304 patients with saphenous vein bypass grafts alone) and group II (176 patients with an internal mammary artery +/- saphenous vein bypass grafts). The long-term results were assessed according to 3 criteria: isolated cardiac mortality: cardiac mortality associated with a repeat revascularisation procedure and cardiac mortality associated with reoperation or recurrence of angina. Cardiac survival at 10 years was significantly better after internal mammary-LAD bypass: 91.4% (CI 87.1-95.1) than after saphenous vein bypass grafting alone: 79.6% (CI 74.8-84.4) (p = 0.012). Univariate analysis identified the following poor predictive factors: three vessel disease (p = 0.03), preoperative left ventricular dysfunction with an ejection fraction inferior to 45% (p = 0.0001), incomplete revascularisation (p = 0.0003), use of venous bypass graft alone (p < 0.014) and perioperative infarction (p = 0.0254). For each criterion of survival (cardiac isolated or associated with a new revascularisation and/or recurrence of angina), multivariate analysis identified three independent predictive factors of long-term extramortality: not using internal mammary artery-LAD bypass graft, incomplete revascularisation and preoperative hypertension. This study confirms the beneficial effects of internal mammary-LAD artery grafting on long-term survival after coronary artery surgery, and also demonstrates the prejudicial effects of hypertension.

  12. Intravascular stents in the last and the next 10 years.

    PubMed

    Palmaz, Julio C

    2004-12-01

    The first balloon-expandable coronary stent was approved "for the prevention of restenosis" in 1994, the same year that the Journal of Endovascular Therapy was inaugurated. Since then, the development of the stent has paralleled the evolution of endovascular intervention as a new specialty. Innovators have pushed to explore new and varied stent applications outside the coronary arteries. Carotid stenting, transjugular intrahepatic portocaval shunts, and covered stents are a few of these new applications that have now become commonplace. Dozens of stent designs and several new materials have been tested to solve the problem of in-stent restenosis, but it is the drug-eluting stent (DES) that has emerged as the most promising, at least in the coronary arteries. However, the benefits of DES technology are not likely to be effective in the more pervasive forms of in-stent restenosis, such as encountered in the femoropopliteal segment. In the future, technologies aimed at stimulating rather than inhibiting tissue response to an implant may be part of the next wave of developments, as we take aim against the poor and/or slow tissue incorporation that manifests as leaks and dislodgement. In the superficial femoral artery, for example, mechanical stresses that cause fractures and dislocations may be addressed by using a very flexible endovascular device with a tissue-friendly inner surface that promotes rapid stent endothelialization to counter the biological effects of motion and microtrauma. The rapidly developing fields of nanotechnology, microelectronics, and advanced materials technology will enable the surface engineer to design molecular-specific surfaces for a new generation of vascular devices. Interactive implantable or injectable microdevices aimed at providing specific information upon demand from an external source will revolutionize disease prevention, as emphasis shifts toward monitoring cardiovascular risk exposure. There is no doubt that during the next 10

  13. "Media Addiction" in a 10-Year-Old Boy.

    PubMed

    Brown, Scott; Scharf, Michael A; Bustos, Cristina; Chavira, Denise; Stein, Martin T

    Bryan is a 10-year-old boy who is brought to his pediatrician by his parents with concerns about oppositional behaviors. Bryan's parents report that he has always been hyperactive and oppositional since a very young age. He has been previously diagnosed with attention-deficit hyperactivity disorder and has been treated with appropriate stimulant medications for several years; however, despite this, his parents feel increasingly unable to manage his difficult behaviors. He refuses to do chores or follow through with household routines. He refuses to go to bed at night. His family feels unable to take him to public places because he "climbs all over everything." At school, he acts up in class, is often disruptive, and requires close supervision by teachers. He was recently kicked off of the school bus. He has very few friends, and his parents state that other children do not enjoy to be around him.Bryan's parents also report that he is "obsessed" with electronics. He spends most his free time watching TV and movies and playing computer games. He has a television in his bedroom because otherwise he "monopolizes" the family television. The family also owns several portable electronic devices that he frequently uses. Bryan insists on watching TV during meals and even that the TV stays on in an adjacent room while showering. He gets up early each morning and turns on the television. He refuses to leave the house unless he can take a portable screen device with him. His parents admit to difficulty placing limits on this behavior because they feel it is the only way to keep his other behaviors under control. His mother explains "it is our only pacifier" and that attempts to place restrictions are met with explosive tantrums and have thus been short lived. These efforts have also been impeded due to the habits of his parents and older sibling, who also enjoy spending a significant amount of time watching television.

  14. Click Chemistry and Radiochemistry: The First 10 Years.

    PubMed

    Meyer, Jan-Philip; Adumeau, Pierre; Lewis, Jason S; Zeglis, Brian M

    2016-12-21

    The advent of click chemistry has had a profound influence on almost all branches of chemical science. This is particularly true of radiochemistry and the synthesis of agents for positron emission tomography (PET), single photon emission computed tomography (SPECT), and targeted radiotherapy. The selectivity, ease, rapidity, and modularity of click ligations make them nearly ideally suited for the construction of radiotracers, a process that often involves working with biomolecules in aqueous conditions with inexorably decaying radioisotopes. In the following pages, our goal is to provide a broad overview of the first 10 years of research at the intersection of click chemistry and radiochemistry. The discussion will focus on four areas that we believe underscore the critical advantages provided by click chemistry: (i) the use of prosthetic groups for radiolabeling reactions, (ii) the creation of coordination scaffolds for radiometals, (iii) the site-specific radiolabeling of proteins and peptides, and (iv) the development of strategies for in vivo pretargeting. Particular emphasis will be placed on the four most prevalent click reactions-the Cu-catalyzed azide-alkyne cycloaddition (CuAAC), the strain-promoted azide-alkyne cycloaddition (SPAAC), the inverse electron demand Diels-Alder reaction (IEDDA), and the Staudinger ligation-although less well-known click ligations will be discussed as well. Ultimately, it is our hope that this review will not only serve to educate readers but will also act as a springboard, inspiring synthetic chemists and radiochemists alike to harness click chemistry in even more innovative and ambitious ways as we embark upon the second decade of this fruitful collaboration.

  15. Examining the 10-year rebuilding dilemma for U.S. fish stocks.

    PubMed

    Patrick, Wesley S; Cope, Jason

    2014-01-01

    Worldwide, fishery managers strive to maintain fish stocks at or above levels that produce maximum sustainable yields, and to rebuild overexploited stocks that can no longer support such yields. In the United States, rebuilding overexploited stocks is a contentious issue, where most stocks are mandated to rebuild in as short a time as possible, and in a time period not to exceed 10 years. Opponents of such mandates and related guidance argue that rebuilding requirements are arbitrary, and create discontinuities in the time and fishing effort allowed for stocks to rebuild due to differences in productivity. Proponents, however, highlight how these mandates and guidance were needed to curtail the continued overexploitation of these stocks by setting firm deadlines on rebuilding. Here we evaluate the statements made by opponents and proponents of the 10-year rebuilding mandate and related guidance to determine whether such points are technically accurate using a simple population dynamics model and a database of U.S. fish stocks to parameterize the model. We also offer solutions to many of the issues surrounding this mandate and its implementation by recommending some fishing mortality based frameworks, which meet the intent of the 10-year rebuilding requirement while also providing more flexibility.

  16. Examining the 10-Year Rebuilding Dilemma for U.S. Fish Stocks

    PubMed Central

    Patrick, Wesley S.; Cope, Jason

    2014-01-01

    Worldwide, fishery managers strive to maintain fish stocks at or above levels that produce maximum sustainable yields, and to rebuild overexploited stocks that can no longer support such yields. In the United States, rebuilding overexploited stocks is a contentious issue, where most stocks are mandated to rebuild in as short a time as possible, and in a time period not to exceed 10 years. Opponents of such mandates and related guidance argue that rebuilding requirements are arbitrary, and create discontinuities in the time and fishing effort allowed for stocks to rebuild due to differences in productivity. Proponents, however, highlight how these mandates and guidance were needed to curtail the continued overexploitation of these stocks by setting firm deadlines on rebuilding. Here we evaluate the statements made by opponents and proponents of the 10-year rebuilding mandate and related guidance to determine whether such points are technically accurate using a simple population dynamics model and a database of U.S. fish stocks to parameterize the model. We also offer solutions to many of the issues surrounding this mandate and its implementation by recommending some fishing mortality based frameworks, which meet the intent of the 10-year rebuilding requirement while also providing more flexibility. PMID:25375788

  17. The GLOBE Program 10 Years On: Challenges and Opportunities

    NASA Astrophysics Data System (ADS)

    Blurton, C.

    2004-12-01

    ). This session will examine what was accomplished during GLOBE's first 10 years as a Federal program, what challenges the Program faces, and what plans are afoot for GLOBE's next ten years under UCAR's leadership.

  18. Efficacy and tolerability of gamma knife radiosurgery in acromegaly: a 10-year follow-up study.

    PubMed

    Ronchi, Cristina L; Attanasio, Roberto; Verrua, Elisa; Cozzi, Renato; Ferrante, Emanuele; Loli, Paola; Montefusco, Laura; Motti, Enrico; Ferrari, Daniela I; Giugni, Enrico; Beck-Peccoz, Paolo; Arosio, Maura

    2009-12-01

    The long-term efficacy and safety of stereotactic radiosurgery by gamma knife (GK) still remain unknown. The aim of the study was to investigate the long-term efficacy and tolerability of GK in acromegalic patients. Retrospective analysis for a median follow-up of 10 years. Thirty-five acromegalic patients from two referral centres in Milan submitted to GK (median margin dose: 20 Gy, median % isodose: 50) between 1995 and 2004. GH/IGF-I secretion, anterior pituitary function, radiological imaging and ophthalmological data. Cure rate improved over time (up to 46% at 10 years), as did the proportion of patients achieving control on somatostatin analogues (from 12.5% at baseline to 50% at 10 years). Normal IGF-I values were observed in 82% of patients at their last visit. No visual impairment, disease recurrence, tumour growth or secondary cerebral tumour occurred. Half of the patients developed one or more new deficiencies, while two patients normalized their prior failures. In particular, new onset of clinical or subclinical hypoadrenalism occurred in 12/30 patients (40%), hypothyroidism in 3/28 (11%), hypogonadism in 2/15 (13%) and GH deficiency in 2/35 (6%). GH value at the time of GK was the best negative predictor of cure and margin dose was the best positive predictor of new hypopituitarism. Over a 10-year period after GK radiosurgery, an increasing percentage of patients achieve cure, or adequate control of the disease on pharmacological therapy, at the expense of increasing novel pituitary deficiencies. © 2009 Blackwell Publishing Ltd.

  19. Corneal Astigmatism in Patients After Cataract Surgery: A 10-Year Follow-up Study.

    PubMed

    Kim, Hyojin; Whang, Woong-Joo; Joo, Choun-Ki

    2016-06-01

    To report the long-term outcomes of corneal astigmatism after cataract surgery. The study included 55 eyes of 46 patients who underwent cataract surgery with temporal 3-mm clear corneal incisions from January 2001 to December 2003. All patients underwent complete ophthalmological examination including keratometry at the preoperative visit and at 2 months and 10 years after surgery. Only those eyes that underwent a follow-up of 10 years or longer from the time of cataract surgery were enrolled. Arithmetic and vector analyses were performed to obtain the change in corneal astigmatism with advancing age. The mean age of the patients was 59.11 ± 12.33 years (range: 18 to 75 years), and 58.7% of the patients were women. The mean follow-up period was 131.28 ± 14.36 months. The average magnitudes of surgically induced astigmatism and long-term astigmatism change were 0.66 ± 0.42 and 0.57 ± 0.47 diopters (D), respectively. The vector difference was 0.56 ± 0.55 D at 90° ± 0° between the preoperative and 2-month visits. However, there was no difference in vector values between postoperative 2 months and 10 years (0.00 ± 0.74 D at 0° ± 0°). Patients with corneal astigmatism who underwent cataract surgery did not show a long-term against-the-rule change in corneal astigmatism during a 10-year follow-up. These results provide useful information when planning toric intraocular lens implantation in patients with corneal astigmatism. [J Refract Surg. 2016;32(6):404-409.]. Copyright 2016, SLACK Incorporated.

  20. Adolescent drug trafficking trends in the United Kingdom--a 10-year retrospective analysis.

    PubMed

    Vale, Ellen Louise Eva; Kennedy, Patrick John

    2004-12-01

    This paper reports data from HM Customs and Excise (HMCE) of recorded cases of adolescent drug trafficking through all sea and air points of entry into the UK over a 10-year period (May 1992-May 2002). We report the characteristics of 38 cases of mixed gender and nationality ranging in age between 13 and 18 years who have been apprehended by HMCE due to the illegal importation of drugs. Highlighted is an increasing trend in UK national male and female adolescents being apprehended for drug trafficking. Of particular note is the observation that more young adolescent females were apprehended importing large consignments of Class A substances than their male counterparts.

  1. Long-term follow-up of heel spur surgery. A 10-year retrospective study.

    PubMed

    Vohra, P K; Giorgini, R J; Sobel, E; Japour, C J; Villalba, M A; Rostkowski, T

    1999-02-01

    A comparative retrospective study of 48 open heel spur surgeries and 20 endoscopic plantar fasciotomies was conducted involving 59 patients over a 10-year period. There was a significant reduction in heel pain at the time of follow-up (average, 3 years) for both groups. Overall, 85% of procedures were associated with patient satisfaction with the results, and patients said that they would recommend heel spur surgery for relief of severe heel pain in 94% of cases. Factors influencing the postoperative outcome, such as duration of preoperative symptoms, extent of conservative care, and obesity, are discussed.

  2. Cumulative survival rate and associated risk factors of Implantium implants: A 10-year retrospective clinical study.

    PubMed

    Park, Jin-Hong; Kim, Young-Soo; Ryu, Jae-Jun; Shin, Sang-Wan; Lee, Jeong-Yol

    2017-06-01

    The objective of this study was to determine the cumulative survival rate (CSR) and associated risk factors of Implantium implants by retrospective clinical study. Patients who received Implantium implants (Dentium Co., Seoul, Korea) at Korea University Guro Hospital from 2004 to 2011 were included. The period between the first surgery and the last hospital visit until December 2015 was set as the observation period for this study. Clinical and radiographic data were collected from patient records, including all complications observed during the follow-up period. Kaplan-Meier analysis was performed to examine CSR. Multiple Cox proportional hazard model was employed to assess the associations between potential risk factors and CSR. A total of 370 implants were placed in 121 patients (mean age, 56.1 years; range, 19 to 75 years). Of the 370 implants, 13 failed, including 7 implants that were lost before loading. The 10-year cumulative survival rate of implants was 94.8%. The multiple Cox proportional hazard model revealed that significant risk factor of implant failure were smoking and maxillary implant (P<.05). The 10-year CSR of Implantium implants was 94.8%. Risk factors of implant failure were smoking and maxillary implant.

  3. A 10-Year Climatology of Amazonian Rainfall Derived from Passive Microwave Satellite Observations

    NASA Technical Reports Server (NTRS)

    Negri, Andrew J.; Anagnostou, Emmanouil N.; Adler, Robert F.

    1998-01-01

    In this study we present and describe a satellite-derived precipitation climatology over northern South America using a passive microwave technique, the Goddard Profiling Algorithm. A period of data slightly longer than 10 years is examined. The climatologies take the form of the mean estimated (adjusted) rainfall for a 10-year (+) period, with sub-divisions by month and meteorological season. For the six-year period 1992-1997, when two satellites were in operation, diurnal variability (to the extent it is discerned by four unequally spaced observations) is presented. We find an alternating pattern of morning and maxima stretching from the northeast (Atlantic coast) clear across the continent to the Pacific. The effects of topography, coastlines and geography (river valleys) on the rainfall patterns are clear. Interannual variability is examined by computing the deviations of yearly and warm season (DJF) rainfall from their respective long-term means. Interannual variability of the diurnal nature of the rainfall is presented, and the strong El Nino event of 1997-1998 is discussed.

  4. [Wavelet analysis on SO2 pollution index changes of Shanghai in recent 10 years].

    PubMed

    Wu, Xiao-ling; Zhang, Bin; Ai, Nan-shan; Liu, Li-jun

    2009-08-15

    Based on the continuous Mexican Hat wavelet transformation of time series of daily SO2 pollution index during last 10 years in Shanghai, the multiscale variations, primary period, catastrophe point and influencing factors are analyzed. The result shows that periodical fluctuation of SO2 pollution index varies at diverse time-scales, and the primary period of the daily variations is about 100 days; pollution pattern takes on serious in winter and light in summer in most scales due to meteorological conditions, and the catastrophe point of serious-light transformation of SO2 pollution index in a year is vernal and autumnal equinox; energy demand and socioeconomic development result in more seriousness in recent years and half result with twice the effort of endeavors of pollution elimination. Wavelet analysis is an effective method to time series of SO2 pollution index, also to multiscale variations of other pollutants.

  5. [Long term (10 years) experience of immediate implant placement].

    PubMed

    István, Vajdovich; Katalin, Nagy

    2009-12-01

    Immediate placement of dental implants have been widely used to retain and support cross-arch partial dentures. 3-6 months after implantation the osseointegration is established. This period may be shortened with immediate implant placement technique. The purpose of this study was to evaluate the factors that may influence the long term success of immediate implantation. Clinical results of 10 yrs period of immediate implant placement were investigated in case of 184 patients and 258 Denti implants. The control was carried out with 121 patients and with 192 implants placed with submerged technique. The retrospective long term follow-up examination has revailed that the success rate of Denti implants with traditional two stage surgery was 97,4%. The success rate of Denti implants with immediate placement was 95.75%. According to the data, the prognosis of immediate implantations-method are compatible (comparable) to the traditional inserted implants.

  6. 26 CFR 1.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... tax return preparer before the assessment of either— (i) A penalty for understating tax liability due... than not be sustained on its merits under section 6694(a) or no substantial authority, as applicable... assessment, the IRS will also send, before assessment of either penalty, a 30-day letter to the tax...

  7. 26 CFR 1.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... examination to the tax return preparer before the assessment of either— (i) A penalty for understating tax... likely than not be sustained on its merits under section 6694(a) or no substantial authority, as... for assessment, the IRS will also send, before assessment of either penalty, a 30-day letter to...

  8. 26 CFR 1.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... examination to the tax return preparer before the assessment of either— (i) A penalty for understating tax... likely than not be sustained on its merits under section 6694(a) or no substantial authority, as... for assessment, the IRS will also send, before assessment of either penalty, a 30-day letter to...

  9. Hospital-based chiropractic integration within a large private hospital system in Minnesota: a 10-year example.

    PubMed

    Branson, Richard A

    2009-01-01

    The purpose of this article is to describe a model of chiropractic integration developed over a 10-year period within a private hospital system in Minnesota. Needs were assessed by surveying attitudes and behaviors related to chiropractic and complementary and alternative medicine (CAM) of physicians associated with the hospital. Analyzing referral and utilization patterns assessed chiropractic integration into the hospital system. One hundred five surveys were returned after 2 mailings for a response rate of 74%. Seventy-four percent of respondents supported integration of CAM into the hospital system, although 45% supported the primary care physician as the gatekeeper for CAM use. From 2006 to 2008, there were 8294 unique new patients in the chiropractic program. Primary care providers (medical doctors and physician assistants) were the most common referral source, followed by self-referred patients, sports medicine physicians, and orthopedic physicians. Overall examination of the program identified that facilitators of chiropractic integration were (1) growth in interest in CAM, (2) establishing relationships with key administrators and providers, (3) use of evidence-based practice, (4) adequate physical space, and (5) creation of an integrated spine care program. Barriers were (1) lack of understanding of chiropractic professional identity by certain providers and (2) certain financial aspects of third-party payment for chiropractic. This article describes the process of integrating chiropractic into one of the largest private hospital systems in Minnesota from a business and professional perspective and the results achieved once chiropractic was integrated into the system. This study identified key factors that facilitated integration of services and demonstrates that chiropractic care can be successfully integrated within a hospital system.

  10. Incidence of skeletal fractures after traumatic spinal cord injury: a 10-year follow-up study.

    PubMed

    Gifre, Laia; Vidal, Joan; Carrasco, Josep; Portell, Enric; Puig, Josep; Monegal, Ana; Guañabens, Núria; Peris, Pilar

    2014-04-01

    To analyse the incidence and factors related to the development and clinical evolution of fractures in patients with traumatic spinal cord injury. A retrospective 10-year follow-up study. Neurorehabilitation centre. Sixty-three patients (50M/13F) with a mean age of 36 ± 20 years with recent traumatic spinal cord injury attended over a one-year period (January to December 2000). Medical reports were reviewed, evaluating risk factors for osteoporosis, fracture incidence during the 10 years following spinal cord injury, severity (ASIA score) and level of spinal cord injury (paraplegia/tetraplegia), type of lesion (spastic/flaccid), weight-bearing standing activity, and the cause, location and evolution of the fracture. Of the 129 patients attending during the study period, 75 had traumatic spinal cord injury (7 died and 5 had no follow-up). Finally, 63 patients were included. Fifty-four per cent had complete motor injury (ASIA A). Twenty-five per cent of these patients developed fractures, with 2.9 fractures per 100 patient-years. The femur was the most frequent location of the fractures. Fractures were observed 6.4 ± 2.4 years after spinal cord injury (range 2-10 years), all in males. Most fractures (70%) were related to low-impact injuries. Fifty per cent presented with associated clinical complications and only 20% of the patients had received anti-osteoporotic treatment. Spinal cord injury severity was the only risk factor for the development of fractures (complete spinal cord injury (ASIA A)) (RR 4.043; 95% confidence interval (CI) 1.081-23.846, P = 0.037). The incidence of fractures after spinal cord injury is high, with severity and time since spinal cord injury being the main determinants for their development. Fractures were frequently associated with clinical complications. However, the use of anti-osteoporotic treatment was uncommon.

  11. Trends in paediatric, neonatal, and adult cardiology publications over the past 10 years.

    PubMed

    Menahem, Samuel; Fink, Daniel; Mimouni, Francis B

    2014-04-01

    Medline classifies publications as clinical trials, randomised control trials, meta-analyses, practice guidelines, reviews, case reports, editorials, and letters. We tested the hypothesis that cardiology-related publications have increased with a shift in the type of publications over the past 10 years by age category. To retrieve from Medline the cardiology articles, we used the keyword "heart disease", but limited the search to articles in English from 2000 to 2009. We repeated the search using one limit according to the publication type and using age tags. We used regression analysis to determine the effect of the year of publication on the number of publications of each type. During the 10-year period, Medline registered 152,849 cardiology articles, doubling from 10,452 in 2000 to 20,841 in 2009, of which 8.5% were tagged as both paediatric and adult. There was a linear increase in the number over the study period in the total number of publications and in all categories, except for practice guidelines. There was almost a twofold increase in adult and neonatal articles, but ∼ 70% in paediatric articles. The rate of increase was 66% for randomised control trials, 73% for clinical trials, 124% for meta-analyses, 117% for editorials, 36% for reviews, and 103% for case reports. Practice guidelines remained very low, increasing significantly for paediatric and neonatal articles. There was a substantial increase in cardiology articles over the past 10 years, being greater for adult and neonatal articles compared with paediatric articles. The increase varied according to the type of article.

  12. Neonatal meningitis in England and Wales: 10 years on

    PubMed Central

    Holt, D; Halket, S; de Louvois, J; Harvey, D

    2001-01-01

    OBJECTIVES—To determine the incidence of neonatal meningitis in England and Wales.
DESIGN—A national postal survey using the British Paediatric Surveillance Unit (BPSU) card scheme supplemented by information from other sources.
SETTING—England and Wales 1996-1997.
SUBJECTS—A total of 274 babies less than 28 days of age who were treated for meningitis.
RESULTS—The incidence of neonatal meningitis in England and Wales has not changed since our previous study in 1985-1987. However, the acute phase mortality has fallen from 19.8% in 1985-1987 to 6.6% in this study. Group B streptococci (42%) and Escherichia coli (16%) remain the most common infecting microorganisms. Eight of 69 (12%) babies with group B streptococci and 4/26 (15%) with E coli died. Antibiotic regimens based on the third generation cephalosporins, notably cefotaxime, were most commonly used (84%). The BPSU scheme identified 72% of cases during the study period. Most cases of viral meningitis were not reported through the BPSU. Less than a third of samples from aseptic meningitis were examined for viruses; 56% of these were positive.
CONCLUSIONS—Although the incidence of neonatal meningitis remains unchanged, mortality from this infection has fallen significantly. If this improvement is maintained as reflected in the level of sequelae at 5 years of age, then the fear surrounding meningitis during the neonatal period will have been dramatically reduced.

 PMID:11207221

  13. Infrared photometry of Venus - Variation during 10 years?

    NASA Astrophysics Data System (ADS)

    Nagata, T.; Sato, S.; Mukai, T.; Mukai, S.

    1985-08-01

    Narrowband filter (3.6-micron wavelength, 0.08-micron bandwidth) observations of the infrared flux of Venus are reported. The observations over the period from 1982 through 1984 covered a range of phase angle from 27 to 94 degrees. Normalized values of flux at the Venus-earth distance of 1 AU were (4.0-5.4) x 10 to the -17th watt per square centimeter per inverse centimeter, and the phase angle dependence of the data is rather weak. Furthermore, when the evening terminator of Venus was seen, lower values of flux were obtained, in contrast with higher values at the morning terminator. The phase angle dependence is quite different from that of Martonchik and Beer (1975), the difference possibly suggesting an intrinsic time variation of haze particles over ten years in the upper haze layer of the Venus cloudcover.

  14. Bacterial nanocellulose production and application: a 10-year overview.

    PubMed

    Jozala, Angela Faustino; de Lencastre-Novaes, Leticia Celia; Lopes, André Moreni; de Carvalho Santos-Ebinuma, Valéria; Mazzola, Priscila Gava; Pessoa-Jr, Adalberto; Grotto, Denise; Gerenutti, Marli; Chaud, Marco Vinicius

    2016-03-01

    Production of bacterial nanocellulose (BNC) is becoming increasingly popular owing to its environmentally friendly properties. Based on this benefit of BNC production, researchers have also begun to examine the capacity for cellulose production through microbial hosts. Indeed, several research groups have developed processes for BNC production, and many studies have been published to date, with the goal of developing methods for large-scale production. During BNC bioproduction, the culture medium represents approximately 30 % of the total cost. Therefore, one important and challenging aspect of the fermentation process is identification of a new cost-effective culture medium that can facilitate the production of high yields within short periods of time, thereby improving BNC production and permitting application of BNC in the biotechnological, medical, pharmaceutical, and food industries. In this review, we addressed different aspects of BNC production, including types of fermentation processes and culture media, with the aim of demonstrating the importance of these parameters.

  15. [Minor salivary gland tumours: a 10-year study].

    PubMed

    Targa-Stramandinoli, Roberta; Torres-Pereira, Cassius; Piazzetta, Cleto M; Giovanini, Allan F; Amenábar, José M

    2009-01-01

    Salivary gland tumours represent between 2 % and 6.5 %, approximately, of all head and neck tumours. The aim of this paper was to identify the frequency of minor salivary gland tumours among patients in the Oral Medicine Clinic of the Federal University of Paraná during the period from 1997 to 2007. A retrospective study was conducted on 1,923 histopathological analyses of oral lesions. Fourteen cases of salivary gland tumours were found, of which 7 were benign and 7 malignant. The lesions were localized mainly in the palate (71.5 %). By histological type, 50 % of the lesions were characterized as pleomorphic adenoma, 28.6 % mucoepidermoid carcinoma, 14.3 % cystic adenoid carcinoma and 7.1 % as polymorphous adenocarcinoma. These findings suggest that salivary gland tumours have a low incidence in the population and that the pleomorphic adenoma is the most common type of tumour, followed by mucoepidermoid carcinoma.

  16. Solar p modes in 10 years of the IRIS network

    NASA Astrophysics Data System (ADS)

    Salabert, D.; Fossat, E.; Gelly, B.; Kholikov, S.; Grec, G.; Lazrek, M.; Schmider, F. X.

    2004-01-01

    IRIS data (the low degree ℓ≤ 3 helioseismology network) have been analysed for the study of p-mode parameters variability over the falling phase of the solar activity cycle 22 and the rising phase of the solar activity cycle 23. The IRIS duty cycle has been improved by the so-called ``repetitive music method'', a method of partial gap filling. We present in this paper an analysis of the dependence of p-mode frequencies and linewidths with frequency and with solar magnetic activity. We confirm also the periodicity of about 70 μHz of the high-frequency pseudo modes, with a much reduced visibility during the phase of higher activity.

  17. Alimentary Tract Atresias associated with Anorectal Malformations: 10 Years' Experience

    PubMed Central

    Saha, Manoj

    2016-01-01

    Anorectal malformation (ARM) is one of the most common congenital anomaly that requires emergency surgery in the neonatal period. ARMs are frequently associated with other life threatening congenital anomalies. Commonly associated anomalies are genito-urinary, cardiovascular, gastro-intestinal, skeletal and spinal. Alimentary tract anomalies are frequently masked by the intestinal obstruction produced by the anorectal atresia. This retrospective study was carried out to find out the incidence of associated alimentary tract atresias with ARM. In our series, out of 785 cases of high ARM, 14 cases had associated esophageal atresia (1.8%), followed by 7 cases of duodenal atresia (0.89%), and followed by pyloric atresia, jejuno-ileal atresia and colonic atresia. PMID:27896151

  18. Enteroviruses in Spain: virological and epidemiological studies over 10 years (1988-97).

    PubMed Central

    Trallero, G.; Casas, I.; Tenorio, A.; Echevarria, J. E.; Castellanos, A.; Lozano, A.; Breña, P. P.

    2000-01-01

    A total of 15,662 clinical samples were analysed for enterovirus (EV) isolation in cell cultures during a 10-year period (1988-97). Furthermore, 210 isolates of EV obtained in primary laboratories within Spain from patients with meningitis were characterized. The total number of EV typed was 758, including 727 non-polio EV and 31 Sabin-like (SL) polioviruses. Twenty-eight EV serotypes were represented. Echoviruses comprised 90% (653/727) of fully typed non-polio EV. The four most prevalent serotypes were echovirus 30, echovirus 9, echovirus 6 and echovirus 4. Echovirus 30 was the main serotype associated with meningitis. Echovirus 9 was the aetiological agent in 20 outbreaks of meningitis while the occurrence of echovirus 6 was localized in 1 year (1997). Coxsackieviruses A and B occurred in 3 and 7% of the non-polio EV respectively. Coxsackievirus B5 presented the relative greater abundance. This paper examines the epidemiology of EV in Spain to serotype level over a 10-year period with special attention to non-polio EV associated with meningitis. PMID:10982074

  19. Foreign body aspiration and language spoken at home: 10-year review.

    PubMed

    Choroomi, S; Curotta, J

    2011-07-01

    To review foreign body aspiration cases encountered over a 10-year period in a tertiary paediatric hospital, and to assess correlation between foreign body type and language spoken at home. Retrospective chart review of all children undergoing direct laryngobronchoscopy for foreign body aspiration over a 10-year period. Age, sex, foreign body type, complications, hospital stay and home language were analysed. At direct laryngobronchoscopy, 132 children had foreign body aspiration (male:female ratio 1.31:1; mean age 32 months (2.67 years)). Mean hospital stay was 2.0 days. Foreign bodies most commonly comprised food matter (53/132; 40.1 per cent), followed by non-food matter (44/132; 33.33 per cent), a negative endoscopy (11/132; 8.33 per cent) and unknown composition (24/132; 18.2 per cent). Most parents spoke English (92/132, 69.7 per cent; vs non-English-speaking 40/132, 30.3 per cent), but non-English-speaking patients had disproportionately more food foreign bodies, and significantly more nut aspirations (p = 0.0065). Results constitute level 2b evidence. Patients from non-English speaking backgrounds had a significantly higher incidence of food (particularly nut) aspiration. Awareness-raising and public education is needed in relevant communities to prevent certain foods, particularly nuts, being given to children too young to chew and swallow them adequately.

  20. Evolution in Practice: How has British Neurosurgery Changed in the Last 10 Years?

    PubMed Central

    Tarnaris, A; Arvin, B; Ashkan, K

    2008-01-01

    INTRODUCTION Neurosurgery is a fast-evolving surgical subspecialty driven by technological advances, socio-economic factors and patient expectations. In this study, we have compared the work-load volume in a single institution in the years of 1994 and 2004 and commented on the possible reasons for the changes and the impacts they may have for the future. PATIENTS AND METHODS A retrospective, log-book review of all operations performed in the years 1994 and 2004 in a single, tertiary, neurosurgical centre was performed. RESULTS Neurosurgical practice has evolved over this period. Current practice has moved away from clipping of aneurysms and towards coil embolisation performed by interventional radiologists. Electrode stimulation of deep brain regions for movement disorders is the current practice, whereas 10 years ago the same disorders were dealt with by lesioning of the relevant regions. In spinal neurosurgery, instrumentation is increasingly favoured currently. In the field of neuro-oncology, current practice favours minimal access to the target area by the use of stereotactic localisation. CONCLUSIONS Changes were most pronounced in the subspecialties of vascular, functional and spinal neurosurgery within this 10-year period. Knowledge of such dynamics is valuable in health resource management as well as planning for neurosurgical training programmes. PMID:18765031

  1. Customising turnaround time indicators to requesting clinician: a 10-year study through balanced scorecard indicators.

    PubMed

    Salinas, Maria; López-Garrigós, Maite; Santo-Quiles, Ana; Gutierrez, Mercedes; Lugo, Javier; Lillo, Rosa; Leiva-Salinas, Carlos

    2014-09-01

    The purpose of this study is, first to present a 10-year monitoring of postanalytical turnaround time (TAT) adapted to different clinicians and patient situations, second to evaluate and analyse the indicators results during that period of time, and finally to show a synthetic appropriate indicator to be included in the balanced scorecard management system. TAT indicator for routine samples was devised as the percentage of certain key tests that were verified before a specific time on the phlebotomy day. A weighted mean synthetic indicator was also designed. They were calculated for inpatients at 15:00 and 12:00 and for primary care patients only at 15:00. The troponin TAT of emergency department patients, calculated as the difference between the troponin verification and registration time, was selected as the stat laboratory TAT indicator. The routine and stat TAT improved along the 10-year study period. The synthetic indicator showed the same trend. The implementation of systematic and continuous monitoring over years, promoted a continuous improvement in TAT which will probably benefit patient outcome and safety.

  2. CHARMM-GUI 10 years for biomolecular modeling and simulation.

    PubMed

    Jo, Sunhwan; Cheng, Xi; Lee, Jumin; Kim, Seonghoon; Park, Sang-Jun; Patel, Dhilon S; Beaven, Andrew H; Lee, Kyu Il; Rui, Huan; Park, Soohyung; Lee, Hui Sun; Roux, Benoît; MacKerell, Alexander D; Klauda, Jeffrey B; Qi, Yifei; Im, Wonpil

    2017-06-05

    CHARMM-GUI, http://www.charmm-gui.org, is a web-based graphical user interface that prepares complex biomolecular systems for molecular simulations. CHARMM-GUI creates input files for a number of programs including CHARMM, NAMD, GROMACS, AMBER, GENESIS, LAMMPS, Desmond, OpenMM, and CHARMM/OpenMM. Since its original development in 2006, CHARMM-GUI has been widely adopted for various purposes and now contains a number of different modules designed to set up a broad range of simulations: (1) PDB Reader & Manipulator, Glycan Reader, and Ligand Reader & Modeler for reading and modifying molecules; (2) Quick MD Simulator, Membrane Builder, Nanodisc Builder, HMMM Builder, Monolayer Builder, Micelle Builder, and Hex Phase Builder for building all-atom simulation systems in various environments; (3) PACE CG Builder and Martini Maker for building coarse-grained simulation systems; (4) DEER Facilitator and MDFF/xMDFF Utilizer for experimentally guided simulations; (5) Implicit Solvent Modeler, PBEQ-Solver, and GCMC/BD Ion Simulator for implicit solvent related calculations; (6) Ligand Binder for ligand solvation and binding free energy simulations; and (7) Drude Prepper for preparation of simulations with the CHARMM Drude polarizable force field. Recently, new modules have been integrated into CHARMM-GUI, such as Glycolipid Modeler for generation of various glycolipid structures, and LPS Modeler for generation of lipopolysaccharide structures from various Gram-negative bacteria. These new features together with existing modules are expected to facilitate advanced molecular modeling and simulation thereby leading to an improved understanding of the structure and dynamics of complex biomolecular systems. Here, we briefly review these capabilities and discuss potential future directions in the CHARMM-GUI development project. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. [Narcotics and illicit drug market. Status and 10-year development].

    PubMed

    Lindholst, Christian; Andreasen, Mette Findal; Kaa, Elisabet

    2008-01-07

    A description of the illicit drug market in Denmark's second largest city is provided based upon the prevalence of narcotics and illicitly sold medicals during the years 2002 and 2003. The changes on the illicit drug market are described by comparing the results to a similar study conducted ten years earlier. The study is comprised of 469 cases of seized material by Aarhus Police during the period January 1st 2002-December 31st 2003. Additional information relating to the 341 persons charged is also included in the study. Heroine, cocaine and amphetamine were seized in 31%, 30% and 28% of the cases, respectively, and comprise the most frequently encountered hard drugs on the market. The prevalence of cocaine in Aarhus Police District has increased more than tenfold during the past ten years. The purity of the three drugs decreased significantly during the same period, although large variations in the quality of drugs were observed. Medicals were found in 16% of the seizures (containing 32 different active substances). The most frequent group of medicals was benzodiazepines, which made up a total of 74% of the medicals in the study. Anabolic steroids, ecstasy and methamphetamine were each found in 4% of the seizures. Men with an average age of 29.1 years comprised 92% of the persons charged in the study. Persons with a foreign nationality comprised 15% of the charged, while 25% had a birthplace outside Denmark. The prevalence of stimulants especially cocaine have increased significantly during the past ten years. Meanwhile the purity of the drugs has decreased. The benzodiazepines are still the most frequent group of medicals on the illicit market.

  4. Lamont-Doherty's Secondary School Field Research Program: 10 years of field research-based education.

    NASA Astrophysics Data System (ADS)

    Newton, R.; Vincent, S.; Gribbin, S.; Peteet, D. M.; Sambrotto, R.; Bostick, B. C.; Corbett, E.; Nguyen, K.; Bjornton, J.; Lee, D.; Dubossi, D.; Reyes, N.

    2014-12-01

    This fall marks the 10th year in which we have run a research-project-based educational program for high school students and science teachers at the Lamont-Doherty Earth Observatory. This summer's cohort included 31 teenagers, 7 science teachers, and 16 college students, most of whom are returning to the program to help run the research projects. Nearly all of our students attend non-competitive-entry public schools in NYC or the neighborhoods around the Observatory. Over 80% are from under-served minority populations. Most receive Title I/III assistance. About 60% are young women. During the past 10 years, nearly all of our participants have gone on to 4-year colleges. About half are declaring science and engineering majors. Our students receive scholarship support at rates several times higher than their graduating peers, including 5 Gates Millennium scholars over the past 5 years. Our science is centered on studies of a nearby tidal wetland, where we have expanded from fish collections in year one to include everything from sediment core analysis to soil chemistry to nutrient cycles to the local food web. In this presentation we will look back over 10 years of experience and focus on what lessons can be learned about (1) how to engage teams of young investigators in authentic scientific research; (2) what cultural/organizational structures encourage them to make use of place- and project-based learning and (3) what the participants themselves report as the most useful aspects of our programming. The presentation will include video clips from the students' field experiences and from reflective interviews with "graduates".

  5. Venus Sample Return Mission

    NASA Astrophysics Data System (ADS)

    Whitcomb, G.; Lebreton, J.; Scoon, G.

    The Venus Sample Return (VSR) mission was performed as an in-house activity within the European Space Agency's Science Directorate during a 4-month period. The selected baseline mission scenario involves two launches of the presently available Ariane 5 configuration. The first launch would inject a composite spacecraft consisting of an orbiter and a return capsule into a parking orbit around Venus. The second launch would deliver at Venus a lander composite, consisting of the entry, descent, sampling and ascent modules. The sampling strategy includes returning a surface (with possibly a core) sample and three atmospheric samples at high altitudes. This paper presents the design concept for the mission.

  6. Long-term use of cellular phones and brain tumours: increased risk associated with use for > or =10 years.

    PubMed

    Hardell, Lennart; Carlberg, Michael; Söderqvist, Fredrik; Mild, Kjell Hansson; Morgan, L Lloyd

    2007-09-01

    To evaluate brain tumour risk among long-term users of cellular telephones. Two cohort studies and 16 case-control studies on this topic were identified. Data were scrutinised for use of mobile phone for > or =10 years and ipsilateral exposure if presented. The cohort study was of limited value due to methodological shortcomings in the study. Of the 16 case-control studies, 11 gave results for > or =10 years' use or latency period. Most of these results were based on low numbers. An association with acoustic neuroma was found in four studies in the group with at least 10 years' use of a mobile phone. No risk was found in one study, but the tumour size was significantly larger among users. Six studies gave results for malignant brain tumours in that latency group. All gave increased odd ratios (OR), especially for ipsilateral exposure. In a meta-analysis, ipsilateral cell phone use for acoustic neuroma was OR = 2.4 (95% CI 1.1 to 5.3) and OR = 2.0, (1.2 to 3.4) for glioma using a tumour latency period of > or =10 years. Results from present studies on use of mobile phones for > or =10 years give a consistent pattern of increased risk for acoustic neuroma and glioma. The risk is highest for ipsilateral exposure.

  7. Competitive employment for consumers who are legally blind: a 10-year retrospective study.

    PubMed

    Bell, Edward

    2010-01-01

    Vocational rehabilitation consumers who are legally blind are a subgroup of the larger population of individuals with disabilities who have suffered high rates of unemployment; yet, the evaluation standards and performance indicators of the Rehabilitation Services Administration (RSA) show that each year, the rates of employment for individuals with disabilities continue to increase overall. The question being investigated is, Has the employment rate similarly increased for this subgroup of consumers? Using the RSA-911 data system, this study investigated the competitive employment rates for consumers who are legally blind over a 10-year period spanning fiscal years 1997 to 2007. This study also compares differences in wages for consumers who were employed when they applied for services versus when they retained or advanced in employment at case closures. Results show that rates of employment and wages have steadily increased for consumers who are legally blind over the period of analysis.

  8. Tracking 10-year competitive winning performance of judo athletes across age groups.

    PubMed

    Julio, Ursula F; Takito, Monica Y; Mazzei, Leandro; Miarka, Bianca; Sterkowicz, Stanislaw; Franchini, Emerson

    2011-08-01

    Little information is available concerning early specialization and competitive success in judo across the early training years. Thus, the present objective was to verify the stability of individual competitive performance of a state-level championship for judo athletes who had been previously successful. For this, 406 athletes from six age groups (9 to 20+ years old) of each sex were followed for 10 years. Using recorded data from the São Paulo State Judo Federation beginning in 1999, the scores and standings for these judo players were analyzed. The proportion of medal winners during this period was not constant, differing from the grand mean in all groups of both 204 males and 202 females. At the end of this period, only 7% of the male and 5% of the female athletes had maintained their competitive levels. Successful competitive performance in early judo competition was not associated with success later in adulthood.

  9. Experiences from 10 years of school programmes at GEOMAR Kiel

    NASA Astrophysics Data System (ADS)

    Dengg, Joachim

    2014-05-01

    GEOMAR Helmholtz Centre for Ocean Research Kiel, Germany, started a programme of cooperations with secondary schools in 2003, which has been expanding continually since that time. By active involvement of teachers and students, the Centre's research topics are communicated to schools, and young people are encouraged to develop their interest for biogeosciences. The portfolio of activities includes: project work with schools over periods from one day to several months, individual student theses at the research centre, internships, a weekly "Research Club" allowing individual experiments, summer school programmes, teacher training courses, joint activities with international partners and a video-project in which students portray scientific aspects of oceanic oxygen minimum zones (in the context of the Collaborative Research Center SFB 754) to other students. Essential prerequisites for these activities are the direct involvement of the Centre's researchers who contribute their expertise and act as role-models for the students, dedicated staff for coordination and continuity, and financial and structural support both at the research centre and the schools.

  10. A 10-year study of snowboard injuries in Lapland Sweden.

    PubMed

    Made, C; Elmqvist, L-G

    2004-04-01

    Snowboard injuries in a Swedish ski area were evaluated from 1989 to 1999. All injured skiers (alpine, telemark, snowboarders) who sought medical attention at the local Medical Center within 48 h of the accident, were asked to answer an injury form. Physicians assessed and treated the injured skiers. There were a total of 1775 injured skiers; 568 injured snowboarders mean age 19 years. The female/male ratio was 34/66%, the injury rate 3/1000 skier days, three times higher than that of alpine skiers. The skill level of the injured snowboard riders improved during the period. The fall/run ratio of the beginners was higher (1.0) and their risk behavior lower (3.9 on visual analogue scale 1-10) in comparison to the advanced riders (0.4 and 6.6, respectively). Injuries were in 54% located to the upper extremity, 35% were wrist/lower arm injuries. Beginners had significantly higher frequency of lower arm/wrist injuries (46%), than average (32%) and advanced riders (20%). The most frequent single diagnosis was wrist/lower arm fracture (20%). Advanced riders tend to have more head/neck injuries than beginners, 17% vs. 13% (NS). Thus, with elevated skill level the injury pattern changed. For injury prevention, wrist guards and helmets are recommended for snowboard riders.

  11. The Dynamics of Free Recall and Their Relation to Rehearsal between 8 and 10 Years of Age

    ERIC Educational Resources Information Center

    Lehmann, Martin; Hasselhorn, Marcus

    2010-01-01

    The present study longitudinally examined changes in recall in children between the ages of 8 and 10 years. Given the increasingly sophisticated use of memory strategies during this developmental period, correspondences between study and recall dynamics were of particular interest. Seventy-six children performed free-recall tasks on 5 occasions…

  12. Ostial stenosis of the left main coronary artery in a young woman 10 years after radiation therapy.

    PubMed

    Orzan, F; Bellis, D; Mollo, F; Brusca, A

    1995-01-01

    A 26-year-old woman developed critical stenosis of the left main coronary artery 10 years after radiation treatment for Hodgkins disease. She was operated on but died in the immediate postoperative period. At autopsy the pathological findings were indistinguishable from those described in "typical" atherosclerotic plaques.

  13. Demography of snowshoe hares in relation to regional climate variabilty during a 10-year population cycle in interior Alaska

    Treesearch

    K. Kielland; K. Olson; E. Euskirchen

    2009-01-01

    We monitored populations of snowshoe hares (Lepus americanus, Erxleben) in interior Alaska for 10 years from 1999 to 2008. During this period, fall densities of hares fluctuated approximately 14-fold. High population growth rates over summer were followed by large population declines over winter. Young-of-the-year hares tended to gain mass over...

  14. Permanence and diffusion of borax-copper hydroxide remedial preservative applied to unseasoned pine posts : 10 year update

    Treesearch

    Douglas Crawford; Stan Lebow; Mike West; Bill Abbott

    2005-01-01

    In 1993, unseasoned pine posts were treated with groundline remedial treatment containing 3.1% copper hydroxide and 40% sodium tetraborate decahydrate (borax). The soundness of the posts was periodically evaluated using a push test. After 3.5, 6.5, and 10 years, sections were taken from two posts to determine retention of borax and copper hydroxide below ground to 36...

  15. Urine cytology of nonurothelial malignancies-a 10-year experience in a large multihospital healthcare system.

    PubMed

    Savant, Deepika; Bajaj, Jaya; Gimenez, Cecilia; Rafael, Oana C; Mirzamani, Neda; Chau, Karen; Klein, Melissa; Das, Kasturi

    2017-01-01

    Urine cytology is the most frequently utilized test to detect urothelial cancer. Secondary bladder neoplasms need to be recognized as this impacts patient management. We report our experience on nonurothelial malignancies (NUM) detected in urine cytology over a 10-year period. A 10-year retrospective search for patients with biopsy-proven NUM to the urothelial tract yielded 25 urine samples from 14 patients. Two cytopathologists blinded to the original cytology diagnosis reviewed the cytology and histology slides. The incidence, cytomorphologic features, diagnostic accuracy, factors influencing the diagnostic accuracy, and clinical impact of the cytology result were studied. The incidence of NUM was <1%. The male:female ratio was 1.3. An abnormality was detected in 60% of the cases; however, in only 4% of the cases, a primary site was identified accurately. Of the false negatives, 96% was deemed as sampling errors and 4% was interpretational. Patient management was not impacted in any of the false-negative cases due to concurrent or past tissue diagnosis. Colon cancer was the most frequent secondary tumor. Sampling error attributed to the false-negative results. Necrosis and dirty background was often associated with metastatic lesions from colon. Obtaining history of a primary tumor elsewhere was a key factor in diagnosis of a metastatic lesion. Hematopoietic malignancies remain to be a diagnostic challenge. Cytospin preparations were superior for evaluating nuclear detail and background material as opposed to monolayer (Thinprep) technology. Diagnostic accuracy was improved by obtaining immunohistochemistry. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc. Diagn. Cytopathol. 2017;45:22-28. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  16. AEROCE - 10 Years of Atmospheric Chemistry at Bermuda

    NASA Astrophysics Data System (ADS)

    Savoie, D. L.

    2001-12-01

    concentrations of mineral dust occur during the summer when advection of air from lower latitudes frequently carries Saharan dust to the site. Along with the dust, Bermuda receives pollution from Europe as well as Africa. However, the major source for pollutants at Bermuda is North America. The highest concentrations of the pollutant aerosol species are associated with rapid and direct boundary layer transport from the United States. Natural processes also play an important role. Dimethylsulfide (DMS), emitted from biological sources in the ocean, is converted to aerosol products, contributing about 30 per cent of the annual mean nonsea-salt sulfate at Bermuda. Chlorine derived from sea-salt may play a significant role in atmospheric oxidation reactions. Another major issue addressed in AEROCE was the rate of transfer of the atmospheric species into the ocean. Removal by precipitation is the major sink for many types of marine aerosols. Scavenging ratios (SRs) are often used to characterize and parameterize the removal flux. When calculated from data averaged over long time periods (e.g., a year or more), SRs are reasonably consistent (within a factor of two) over extensive marine regions. Scavenging processes are, however, complex and vary greatly over time and space. This is reflected in monthly SRs that vary over factors of 2 to 5 at Bermuda, and in daily SRs that vary over an order of magnitude. Consequently, removal fluxes parameterized over short periods of time are still highly uncertain.

  17. [Primary acute myocarditis. A 10- years institutional experience].

    PubMed

    Guillén-Ortega, Fernando; Soto, María Elena; Reyes, Pedro A

    2005-01-01

    Acute myocarditis (AM) is associated with viral infections: Coxsackie and ECHOviruses among others. Autoimmunity has been proposed as a pathogenic mechanism. Benefit of classic immunosuppression (prednisone-azathioprine) or immunomodulation (monomeric-human IgG) is still uncertain. To review incidence and clinical approach to AM at a Cardiology referral center. A 10-yeard period (1992-2003) is reviewed. A standard questionary was applied to 49 consecutive patients referred by clinicians with a diagnosis of AM. AM was found in 17 women and 32 men, median age 24 and 28 years, respectively. They presented heart failure with dyspnea/ortopnea (70-47%), peripheral edema/jugular vein plethora (41-37%), chest pain, and tachycardia (50%), NYHA functional class was Ill-IV in 22. The EKG showed sinus tachycardia or conduction defects. Transthoracic echocardiograms in 47 cases showed EF (mean) of 41% with enlarged left ventricle diameter. Antivirus antibodies were present in 54% of those cases studied, Coxsackie or ECHOvirus were identified through a serologic assay. Twenty-nine (61%) of our cases developed dilated cardiomyopathy, three patients died. It is not possible to reach a conclusion regard to immunomodulation therapy, because it was applied to only 12 patients. At the Instituto Nacional de Cardiología "I. Chávez", AM depicts an incidence of 1/1,000 patients a year. It is necessary to standardize the clinical approach for diagnosis and treatment, progression to dilated cardiomyopathy and death during acute stage occurs in two-thirds of our patients.

  18. Peripheral Arterial Pseudoaneurysms-a 10-Year Clinical Study.

    PubMed

    Luther, Anil; Kumar, Amit; Negi, Kamal Nabh Rai

    2015-12-01

    Peripheral arterial pseudoaneurysms are quite common in Northern India (Punjab Province) and thus a common presenting complaint of varied etiology. The objective of this study was to evaluate the clinical outcome of patients presenting with peripheral arterial pseudoaneurysms of varied etiology. Retrospective analysis of medical records of patients with diagnosis of peripheral arterial pseudoaneurysm from 1 May 2001 to 30 October 2009 was done. In the prospective period from 1 November 2009 to 30 April 2011, the patients were personally examined by the authors and followed up till discharge from the hospital and subsequently at 2 weeks, 1 month, 3 months, and 6 months postdischarge from the hospital. We studied 50 patients (13 in the prospective group and 37 in the retrospective study group). Intravenous drug abuse (26 cases) followed by trauma (nine cases) was the commonest etiology. Femoral artery was the commonest artery involved (37 cases). A pulsatile mass with localized tenderness was the commonest presentation. All patients underwent surgical treatment with 36 (72 %) patients undergoing ligation and excision of the pseudoaneurysm. Six (12 %) patients underwent revascularization with reverse saphenous vein graft. Five (10 %) patients underwent primary repair, and three (6 %) patients were managed by putting a synthetic ePTFE graft. Postoperative wound infection was seen in 18 (36 %) patients, and 33 (66 %) patients had an uneventful recovery. In pseudoaneurysms, surgical repair at the early instance carries a favorable prognosis. If feasible, reverse saphenous vein grafting is the best conduit for repair. Synthetic vascular graft (ePTFE) can be used in case autologous saphenous vein is not available. Excision and ligation is safe, and we recommend it as the treatment of choice for infected arterial pseudoaneurysms.

  19. RECONSTRUCTION OF THE ANTERIOR CRUCIATE LIGAMENT WITH THE CENTRAL THIRD OF THE QUADRICEPS MUSCLE TENDON: ANALYSIS OF 10-YEAR RESULTS

    PubMed Central

    Guimarães, Marcus Valladares; Junior, Lúcio Honório de Carvalho; Terra, Dalton Lopes

    2015-01-01

    Objective: Assess clinical results using two different protocols, 10 years after ACL reconstruction surgery with the central third of quadriceps muscle tendon (QT). Method: Between November /1997 and April/1998, 25 patients were submitted to 25 ACL reconstructions with QT by transtibial technique. The bone portion of the graft was fixated on femoral tunnel with interference screw and the tendinous portion of tibial tunnel with screw with washer. Two patients injured the new when playing soccer. Six patients were not available for follow-up (24%). Seventeen patients were evaluated, 15 men and two women, with mean age at surgery time of 28.53 ± 6.64 years. All patients were examined at six months, one year, and ten years after surgery. Clinical evaluation was made by the Lysholm scale, and the knee evaluation, with the Hospital for Special Surgery scale. Results: The patients had their injuries operated after 9.87 ± 14.42 months of the accident. According to Lysholm scale, the results at the end of the first year were 98.71 ± 2.47 and, after 10 years, 97.35 ± 3.12. Using the Hospital for Special Surgery scale, the mean score was 95.07 ± 5.23 in one year, and 94.87 ± 4.16 in 10 years. All patients returned to their professional activities with the same previous status. Fifteen (88.24%) patients were able to return to their sports activities, one by modifying the practice, while another one switched to another sport. No patient complained of pain on the donor area in the medium and long term. The sports return rate was excellent, and no changes were found on the femoropatellar joint. PMID:27022511

  20. Incremental peritoneal dialysis: a 10 year single-centre experience.

    PubMed

    Sandrini, Massimo; Vizzardi, Valerio; Valerio, Francesca; Ravera, Sara; Manili, Luigi; Zubani, Roberto; Lucca, Bernardo J A; Cancarini, Giovanni

    2016-12-01

    Incremental dialysis consists in prescribing a dialysis dose aimed towards maintaining total solute clearance (renal + dialysis) near the targets set by guidelines. Incremental peritoneal dialysis (incrPD) is defined as one or two dwell-times per day on CAPD, whereas standard peritoneal dialysis (stPD) consists in three-four dwell-times per day. Single-centre cohort study. Enrollement period: January 2002-December 2007; end of follow up (FU): December 2012. incident patients with FU ≥6 months, initial residual renal function (RRF) 3-10 ml/min/1.73 sqm BSA, renal indication for PD. Median incrPD duration was 17 months (I-III Q: 10; 30). There were no statistically significant differences between 29 patients on incrPD and 76 on stPD regarding: clinical, demographic and anthropometric characteristics at the beginning of treatment, adequacy indices, peritonitis-free survival (peritonitis incidence: 1/135 months-patients in incrPD vs. 1/52 months-patients in stPD) and patient survival. During the first 6 months, RRF remained stable in incrPD (6.20 ± 2.02 vs. 6.08 ± 1.47 ml/min/1.73 sqm BSA; p = 0.792) whereas it decreased in stPD (4.48 ± 2.12 vs. 5.61 ± 1.49; p < 0.001). Patient survival was affected negatively by ischemic cardiopathy (HR: 4.269; p < 0.001), peripheral and cerebral vascular disease (H2.842; p = 0.006) and cirrhosis (2.982; p = 0.032) and positively by urine output (0.392; p = 0.034). Hospitalization rates were significantly lower in incrPD (p = 0.021). Eight of 29 incrPD patients were transplanted before reaching full dose treatment. IncrPD is a safe modality to start PD; compared to stPD, it shows similar survival rates, significantly less hospitalization, a trend towards lower peritonitis incidence and slower reduction of renal function.

  1. [Cardiac rehabilitation in patients with myocardial infarction: a 10-year follow-up study].

    PubMed

    Maroto Montero, José M; Artigao Ramírez, Rosario; Morales Durán, María D; de Pablo Zarzosa, Carmen; Abraira, Víctor

    2005-10-01

    Very little information is available on the effect of cardiac rehabilitation programs on long-term survival. The primary aim of this study was to assess the effect of a structured cardiac rehabilitation program on mortality in patients who had suffered acute myocardial infarction. The secondary endpoint was the effect on morbidity. The study included 180 low-risk male patients aged under 65 years. Patients were randomly assigned to one of 2 groups: 90 entered into a comprehensive cardiac rehabilitation program, and 90 served as a control group. The mean follow-up period was 10 years. All-cause mortality was significantly lower in the intervention group: the 10-year survival rate was 91.8% in the intervention group compared with 81.7% in the control group (P=.04). There was also a decrease in cardiovascular mortality, though it was not statistically significant: the 10-year survival rate was 91.8% in the intervention group compared with 83.8% in the control group (P=.10). The incidence of non-fatal complications was lower in the intervention group (35.2% vs 63.2%, P=.03), as was the incidence of unstable angina (15.7% vs 33.9%, P =.02) and cardiac heart failure (3.0% vs 14.4%, P=.02), and the need for coronary intervention (8.4% vs 22.9%, P=.02). The application of a comprehensive cardiac rehabilitation program significantly decreased long-term mortality and morbidity in low-risk patients after acute myocardial infarction.

  2. Safety of Quadrivalent Meningococcal Conjugate Vaccine in Children 2-10 Years.

    PubMed

    Tartof, Sara Y; Sy, Lina S; Ackerson, Bradley K; Hechter, Rulin C; Haag, Mendel; Slezak, Jeffrey M; Luo, Yi; Fischetti, Christine A; Takhar, Harp S; Miao, Yan; Solano, Zendi; Jacobsen, Steven J; Tseng, Hung-Fu

    2017-07-14

    Quadrivalent meningococcal conjugate vaccine is recommended for children, adolescents, and adults at increased risk of meningococcal disease. In 2011, MenACWY-CRM (Menveo, GSK) was approved for children aged 2-10 years in the U.S. Although no safety concerns arose from clinical trials, it remains important to monitor its safety in routine clinical settings. Kaiser Permanente Southern California members 2-10 years old who received MenACWY-CRM between September 2011 and September 2014 were included. Electronic health records were searched using a validated algorithm to identify 26 pre-specified events of interest (EOIs) and serious medically attended events (SMAEs) from inpatient or emergency settings up to one year following MenACWY-CRM vaccination. SMAEs were categorized by ICD-9 diagnostic categories. All events were reviewed to confirm the diagnosis and symptom onset date. The study was descriptive (NCT01452438); no statistical tests were performed. Among 387 vaccinated children, 327 with ≥6 months membership before vaccination were analyzed. Among EOIs, 9 asthma cases and one myasthenia gravis case underwent chart review which confirmed one incident asthma case occurring 237 days after concomitant vaccination with MenACWY-CRM and typhoid vaccine. Thirty-one children experienced SMAEs, most commonly due to unrelated injury and poisoning. The remaining events occurred sporadically after vaccination and most were unlikely related to vaccination based on medical record review. One incident EOI of asthma late in the 1-year observation period and sporadic distribution of SMAEs were observed. These data do not suggest safety concerns associated with MenACWY-CRM vaccination in children 2-10 years old.

  3. Vertical scar versus the inverted-T scar reduction mammaplasty: a 10-year follow-up.

    PubMed

    Bouwer, Lesley R; van der Biezen, Jan Jaap; Spronk, Cees A; van der Lei, Berend

    2012-10-01

    A retrospective study was undertaken to evaluate whether the initial outcome of two types of reduction mammaplasty techniques (vertical scar reduction mammaplasty vs. the inverted-T scar reduction mammaplasty) remains stable in the long term: Sixty-nine patients who had undergone breast reduction surgery in the period 1997-2000 at the Department of Reconstructive Plastic Surgery at the Medical Center of Leeuwarden were willing and able to participate in this study. A structured questionnaire was used to assess the degree of patient satisfaction. For subjective evaluation, the Strasser Grading System on photographs at the 3 months after surgery and after long-term follow-up (10 years) was used. The median general appreciation mark for the entire surgical procedure given by patients was 8 (1-10) on a scale from 1 to 10. Forty-six of the 69 patients could be scored according to Strasser: at 3 months in 17 patients (37%) the result was 'good', in 21 patients (46%) 'mediocre' and in eight patients (17%) 'poor'. After 10 years, in 37 of the patients (80%) the result was 'good', in six patients (13%) 'mediocre' and in three patients (7%) 'poor'. At 3 months, there was a higher incidence of bottoming out in the vertical scar group (one on two patients) as compared to the inverted-T scar group (one on 10 patients); however, at the 10-years follow-up bottoming out was 50% in the inverted-T scar group and 20% in the vertical scar group. Despite bottoming out, in both the vertical scar reduction mammaplasty technique and the inverted-T scar reduction mammaplasty technique, high patient satisfaction rates are achieved that remains for years. Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  4. Surgical treatment in Osteogenesis Imperfecta – 10 years experience

    PubMed Central

    Georgescu, I; Vlad, C; Gavriliu, TȘ; Dan, S; Pârvan, AA

    2013-01-01

    Introduction. Osteogenesis imperfecta (OI) is a very rare disease compared to other afflictions, running the risk of social isolation for children and their parents, due to the problems specific to the disease. All the social, psychological and physical disadvantages must be removed or at least mitigated, all within the society’s limited resources. In Romania, this situation has led in the last couple of years to the selection of a number of extremely severe cases, which could not be solved by orthopedic and classic surgical treatment methods. These patients exhibit gracile long bones, which are distorted, often with cystic degeneration at the level of the extremities, pseudarthroses, limb length discrepancies, most of them being unable to walk, being condemned to sitting in a wheelchair. Aim. This paper deals with the experience of the Orthopedics Department of "Maria Sklodowska Curie" Clinical Emergency Hospital for Children, in Bucharest, in the field of surgical treatment for moderate and severe forms of OI, within the time frame of May 2002-May 2012. For the first time in Romania, on May 20, 2002, the team led by Professor Gh. Burnei, MD, has implanted telescopic rods in the femur and tibia of a patient with OI. One of the most important themes, of great interest in the orthopedic surgery, is the osteoarticular regularization and reconstruction in severe forms of OI, which should allow the patients to stand and walk. These cases are a challenge for the surgeon, who is in the position of applying new, complex procedures, or perfecting, modifying and adapting techniques that have already been established. The aim of the surgical treatment is the increase of the quality of life of these children and adolescents and of their social integration. Methods and results. In the above-mentioned period, from the OI patients who are in the evidence of our clinic, 32 were operated on, totaling 81 surgeries. Out of these, 28 patients, aged 2-27 years, have benefited from

  5. Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome.

    PubMed

    Oishi, Naoki; Inoue, Yasuhiro; Saito, Hideyuki; Kanzaki, Sho; Kanzaki, Jin; Ogawa, Kaoru

    2010-04-01

    To determine the long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome of low-frequency hearing loss. Case series with chart review. Tertiary referral center. From 1979 to 1998, 466 consecutive patients with low-frequency hearing loss received initial treatment at the Hearing and Tinnitus Clinic of Keio University Hospital. Of the 49 eligible patients, pure-tone threshold data obtained over a period of 10 years after onset of low-frequency hearing loss were available for analysis. To determine the progression of hearing loss, we analyzed audiometric pattern changes. We also examined how the following factors affected 10-year prognosis: sex, age, side of hearing loss, accompanying dizziness, pre-therapeutic hearing thresholds at low frequencies, initial therapy results, and fluctuation of hearing during the first year after onset. High- and pan-frequency hearing loss increased as time progressed. About half of the cases developed high- or pan-frequency hearing loss within 10 years of onset. Audiometric patterns measured at 10 years significantly correlated with those measured at one (r = 0.57), three (r = 0.73), and five years (r = 0.85). The 10-year prognosis significantly correlated with only two factors: initial therapy results (r = 0.49) and fluctuation of hearing during the first year (r = 0.43). About half of the cases in our study developed high- or pan-frequency hearing loss within 10 years of onset of low-frequency hearing loss. The initial therapy results and fluctuation of hearing during the first year may indicate the long-term prognosis of patients presenting with low-frequency hearing loss. Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.

  6. Post-Test Analysis of a 10-Year Sodium Heat Pipe Life Test

    NASA Technical Reports Server (NTRS)

    Rosenfeld, John H.; Locci, Ivan E.; Sanzi, James L.; Hull, David R.; Geng, Steven M.

    2011-01-01

    High-temperature heat pipes are being evaluated for use in energy conversion applications such as fuel cells, gas turbine re-combustors, Stirling cycle heat sources; and with the resurgence of space nuclear power both as reactor heat removal elements and as radiator elements. Long operating life and reliable performance are critical requirements for these applications. Accordingly, long-term materials compatibility is being evaluated through the use of high-temperature life test heat pipes. Thermacore, Inc., has carried out a sodium heat pipe 10-year life test to establish long-term operating reliability. Sodium heat pipes have demonstrated favorable materials compatibility and heat transport characteristics at high operating temperatures in air over long time periods. A representative one-tenth segment Stirling Space Power Converter heat pipe with an Inconel 718 envelope and a stainless steel screen wick has operated for over 87,000 hr (10 years) at nearly 700 C. These life test results have demonstrated the potential for high-temperature heat pipes to serve as reliable energy conversion system components for power applications that require long operating lifetime with high reliability. Detailed design specifications, operating history, and post-test analysis of the heat pipe and sodium working fluid are described. Lessons learned and future life test plans are also discussed.

  7. Prospective Predictors of Body Dissatisfaction in Young Adults: 10-year Longitudinal Findings

    PubMed Central

    Quick, Virginia; Eisenberg, Marla E.; Bucchianeri, Michaela M.; Neumark-Sztainer, Dianne

    2014-01-01

    This study identified longitudinal risk factors for body dissatisfaction (BD) over a 10-year period from adolescence to young adulthood. Participants (N = 2134; age at baseline: M =15.0, SD =1.6 years) provided two waves of survey data. A 6-step hierarchical linear regression analysis examined the predictive contribution of Time 1 BD, weight status, demographics, family and peer environmental factors, and psychological factors. Among females, Asian race/ethnicity, low self-esteem, greater BD, and higher body mass index during adolescence contributed significantly to predicting greater BD at 10-year follow up (R2 = 0.27). Among males, demographics (i.e., Asian, other-mixed ethnicity, education attainment), depressive symptoms, greater BD, higher body mass index, more parent communication, and less peer weight teasing during adolescence contributed to BD at follow-up (R2 = 0.27). Findings indicate who may be at greatest risk for BD in young adulthood and the types of factors that should be addressed during adolescence. PMID:25045599

  8. Ewing sarcoma family of tumors in children younger than 10 years of age.

    PubMed

    Huh, Winston W; Daw, Najat C; Herzog, Cynthia E; Munsell, Mark F; McAleer, Mary Frances; Lewis, Valerae O

    2017-04-01

    Few data exist regarding the clinical characteristics and outcome of young children with Ewing sarcoma family of tumors (ESFT). We reviewed the records of ESFT patients at our institution younger than 10 years of age at diagnosis. Forty-two patients were identified. Median age was 6.4 years (range 0.6-9.5 years). Most patients had T2 (>5 cm) tumors (n = 31; 74%). Most common primary site was the extremity (n = 17; 41%). Seven patients (17%) had metastasis at diagnosis. For local tumor control, 20 patients had surgery only, 13 had radiation therapy only, and 6 had surgery plus radiation. Surgical margin status was negative in 19 patients (73%). Median follow-up was 4.7 years (range 0.7-29.7 years), and 5-year relapse-free survival (RFS) and overall survival (OS) estimates were 67% (95% CI: 53-84%) and 82% (95% CI: 71-95%), respectively. Metastasis at presentation was the only significant predictor for decreased RFS (P = 0.008) and OS (P = 0.01). A trend was seen for T2 tumors with worse OS (P = 0.09). Patients younger than 10 years of age with ESFT may have a better OS than older patients, but further study of a homogeneously treated larger cohort is needed. © 2016 Wiley Periodicals, Inc.

  9. Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis.

    PubMed

    Kuehhas, F E; Miernik, A; Weibl, P; Schoenthaler, M; Sevcenco, S; Schauer, I; Tosev, G; Oezsoy, M; Lassmann, J

    2013-01-01

    Evaluation of the true incidence of balanitis xerotica obliterans (BXO) among boys younger than 10 years. In a period of 13 months, 75 boys younger than 10 years were treated for phimosis. Suspicion of BXO was raised in phimosis grade 2 or 3 (classification by Kikiros). Patients were offered primarily either circumcision or conservative therapy and circumcision secondarily (if treatment failed in the conservative group). Each circumcision specimen was examined histopathologically. Circumcision was primarily performed in 29 and secondarily in 17 patients. The mean age was 3.7 years (range 1-10). BXO, chronic inflammation, and normal histological results were found in 8/26/12 (17.4/56.5/26.1%) cases, respectively. The mean follow-up was 8.1 months. No recurrences were reported. The incidence of BXO appears to be higher than previously reported. The clinical appearance in children may be confusing. The preoperative BXO suspicion did not correlate with the final histopathological results. Copyright © 2012 S. Karger AG, Basel.

  10. [Food avoidance emotional disorder in 3 to 10-year-old children: a clinical reality].

    PubMed

    Goëb, J-L; Azcona, B; Troussier, F; Malka, J; Giniès, J-L; Duverger, P

    2005-09-01

    We underline the clinical importance of a specific eating disorder in 3 to 10 years old children, when the majority of the works about the prepubertal eating disorders focus either on the period just preceding adolescence (often between 10 and 13 years), or on the second half of the first year of the baby. Within the eating disorders described in the literature, we compare the clinical presentation of most of these 3 to 10 years old children with the food avoidance emotional disorder described during adolescence. These problems of eating behaviour (various selective eating with or without provoked vomiting) are ignored for a long time in these young children because of quite a satisfactory growth, but these children are often seen in emergency rooms because of a brutally complete eating refusal. Therapeutic consultations allow these children to express their fears about diseases, poisoning and death, for themselves or for their close relations, in particular the mother, without endangering their body. The early recognition and care of these difficulties of conciliation between the body and the thoughts impose a narrow collaboration between paediatric and psychiatric staffs.

  11. Veneered zirconia inlay-retained fixed dental prostheses: 10-Year results from a prospective clinical study.

    PubMed

    Rathmann, Friederike; Bömicke, Wolfgang; Rammelsberg, Peter; Ohlmann, Brigitte

    2017-09-01

    The purpose of this study was to evaluate the 10-year clinical performance of zirconia-based inlay-retained fixed dental prostheses (IRFDP). For replacement of a molar in 27 patients, 30 IRFDP were luted by use of different cements, Panavia F (Kuraray Europe GmbH) or Multilink Automix (Ivoclar Vivadent GmbH), with use of inlay/inlay, inlay/full-crown, or inlay/partial-crown retainers for anchorage. Frameworks were milled from yttria-stabilized zirconia (IPS e.maxZirCAD; Ivoclar Vivadent GmbH) and fully veneered with pressable ceramic (IPS e.max ZirPress; Ivoclar Vivadent GmbH). Before luting, the IRFDP were silica-coated (Rocatec; 3M Espe) and silanized (Monobond S; Ivoclar Vivadent GmbH). Complications (for example, chipping or delamination of the veneering ceramic, debonding, secondary caries, endodontic treatment, and abutment tooth fracture) and failure were reported, by use of standardized report forms, 2 weeks, 6 months, and 1, 2, and 10 years after cementation. Statistical analysis included Kaplan-Meier survival and success (complication-free survival) and Cox regression analysis (α=0.05 for all). During the 10-year observation period, the complications most often observed were chipping of the veneer and debonding. Twenty-five restorations failed and one participant dropped out. Cumulative 10-year survival and success were 12.1% and 0%, respectively. The design of the retainer, use of a dental dam, choice of cement, and location in the dental arch had no statistically significant effect on the occurrence of complications. Use of fully veneered zirconia-based IRFDP with this technique cannot be recommended. A large incidence of complications and poor survival were observed for fully veneered zirconia-based IRFDP, revealing an urgent need for further design improvements for this type of restoration. This, again, emphasizes the need for testing of new restoration designs in clinical trials before implementation in general dental practice. Copyright © 2017

  12. Late Lung Metastasis of a Primary Eccrine Sweat Gland Carcinoma 10 Years after Initial Surgical Treatment: The First Clinical Documentation

    PubMed Central

    Falkenstern-Ge, R. F.; Bode-Erdmann, S.; Ott, G.; Wohlleber, M.; Kohlhäufl, M.

    2013-01-01

    Background. Sweat gland carcinoma is a rare malignancy with a high metastatic potential seen more commonly in elderly patients. The scalp is the most common site of occurrence and it usually spreads to regional lymph nodes. Liver, lungs, and bones are the most common sites of distant metastasis. Late lung metastasis of sweat gland adenocarcinoma after a time span of 5 years is extremely rare. Aim. We report a patient with late lung metastasis of a primary sweat gland carcinoma 10 years after initial surgical resection. Conclusion. Sweat gland carcinomas are rare cancers with a poor prognosis. Surgery in the form of wide local excision and lymph node dissection is the mainstay of treatment. Late pulmonary metastases with a latency of 10 years have never been reported in the literature. This is the first clinical documentation of late lung metastasis from sweat gland carcinoma with a latency period of 10 years. PMID:23710393

  13. Late lung metastasis of a primary eccrine sweat gland carcinoma 10 years after initial surgical treatment: the first clinical documentation.

    PubMed

    Falkenstern-Ge, R F; Bode-Erdmann, S; Ott, G; Wohlleber, M; Kohlhäufl, M

    2013-01-01

    Background. Sweat gland carcinoma is a rare malignancy with a high metastatic potential seen more commonly in elderly patients. The scalp is the most common site of occurrence and it usually spreads to regional lymph nodes. Liver, lungs, and bones are the most common sites of distant metastasis. Late lung metastasis of sweat gland adenocarcinoma after a time span of 5 years is extremely rare. Aim. We report a patient with late lung metastasis of a primary sweat gland carcinoma 10 years after initial surgical resection. Conclusion. Sweat gland carcinomas are rare cancers with a poor prognosis. Surgery in the form of wide local excision and lymph node dissection is the mainstay of treatment. Late pulmonary metastases with a latency of 10 years have never been reported in the literature. This is the first clinical documentation of late lung metastasis from sweat gland carcinoma with a latency period of 10 years.

  14. Treatment and violent behavior in persons with first episode psychosis during a 10-year prospective follow-up study.

    PubMed

    Langeveld, Johannes; Bjørkly, Stål; Auestad, Bjørn; Barder, Helene; Evensen, Julie; Ten Velden Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan Ivar; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2014-07-01

    First episode psychosis (FEP) patients have an increased risk for violence and criminal activity prior to initial treatment. However, little is known about the prevalence of criminality and acts of violence many years after implementation of treatment for a first episode psychosis. To assess the prevalence of criminal and violent behaviors during a 10-year follow-up period after the debut of a first psychosis episode, and to identify early predictors and concomitant risk factors of violent behavior. A prospective design was used with comprehensive assessments of criminal behavior, drug abuse, clinical, social and treatment variables at baseline, five, and 10-year follow-up. Additionally, threatening and violent behavior was assessed at 10-year follow-up. A clinical epidemiological sample of first-episode psychosis patients (n=178) was studied. During the 10-year follow-up period, 20% of subjects had been apprehended or incarcerated. At 10-year follow-up, 15% of subjects had exposed others to threats or violence during the year before assessment. Illegal drug use at baseline and five-year follow-up, and a longer duration of psychotic symptoms were found to be predictive of violent behavior during the year preceding the 10-year follow-up. After treatment initiation, the overall prevalence of violence in psychotic patients drops gradually to rates close to those of the general population. However, persistent illicit drug abuse is a serious risk factor for violent behavior, even long after the start of treatment. Achieving remission early and reducing substance abuse may contribute to a lower long-term risk for violent behavior in FEP patients. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. [Bilateral submandibulectomy for the treatment of drooling in pediatric age: 10 years of experience].

    PubMed

    Marinho, A S; Sousa, C; Coelho, A; Barbosa-Sequeira, J; Recamán, M; Carvalho, F

    2016-07-10

    Sialorrhea is a medical problem and can become a social issue, common in children with neurological disabilities. The bilateral submandibulectomy is one of the available treatment options for managing this pathology. The aim of this study is to evaluate the effectiveness of bilateral submandibulectomy in the management of sialorrhea in children with neurological disabilities through the parents' satisfaction grade. We retrospectively analyzed 91 bilateral submandibulectomies for a period of time of 10 years (2004-2015). Data were taken from surgical records and patients files and were informatically processed. The severity grade before and after surgery was evaluated in line with the modified Teacher scale. Parental satisfaction was evaluated by applying a scale graded into five classes, according to the degree of sialorrhea severity in postoperative period. During the reporting period, 91 children underwent bilateral submandibulectomy in our center. Of these, 7 cases were excluded for lack of data. The average age of the children was 8,9 [± 3,5] years; 58,3% were male. The degree of preoperative sialorrhea severity was, in 52,4% of cases, level 4 (severe drooling), and in 28,6%, level 5 (very severe). The grade of parental satisfaction in postoperative period was ranked, in 73,8% of cases, between 81-100%. For children with drooling, a bilateral submandibulectomy emerges as an effective and efficient treatment, leaving parents with an extremely high satisfaction grade.

  16. Health Care Finance Executive Personalities Revisited: A 10-Year Follow-up Study.

    PubMed

    Lieneck, Cristian; Nowicki, Michael

    2015-01-01

    A dynamic health care industry continues to call upon health care leaders to possess not one but multiple competencies. Inherent personality characteristics of leaders often play a major role in personal as well as organizational success to include those in health care finance positions of responsibility. A replication study was conducted to determine the Myers-Briggs personality-type differences between practicing health care finance professionals in 2014, as compared with a previous 2003 study. Results indicate a significant shift between both independent samples of health care finance professionals over the 10-year period from original high levels of introversion to that of extraversion, as well as higher sensing personality preferences, as compared with the original sample's high level of intuition preferences. Further investigation into the evolving role of the health care finance manager is suggested, while continued alignment of inherent, personal characteristics is suggested to meet ongoing changes in the industry.

  17. From Exotic to Mainstream: A 10-year Odyssey from Internet Speed to Boundary Spanning with Scrum

    NASA Astrophysics Data System (ADS)

    Baskerville, Richard; Pries-Heje, Jan; Madsen, Sabine

    Based on four empirical studies conducted over a 10-year time period from 1999 to 2008 we investigate how local software processes interact with global changes in the software development context. In 1999 companies were developing software at high speed in a desperate rush to be first-to-market. In 2001 a new high speed/quick results development process had become established practice. In 2003 changes in the market created the need for a more balanced view on speed and quality, and in 2008 companies were successfully combining agile and plan driven approaches to achieve the benefits of both. The studies reveal a twostage pattern in which dramatic changes in the market causes disruption of established practices, experimentation, and process adaptations followed by consolidation of lessons learnt into a new (and once again mature) software development process. Limitations, implications, and areas for future research are discussed.

  18. The Effects of Lack of Joint Goal Planning on Divorce over 10 Years

    PubMed Central

    Gere, Judith; Almeida, David M.; Martire, Lynn M.

    2016-01-01

    Given the negative consequences of divorce on health and well-being, it is important to try to identify its predictors. In the current study we used data from the National Survey of Midlife Development (N = 2801) to examine the longitudinal effects of lack of joint goal planning with a romantic relationship partner on divorce over a 10-year period. Multilevel regression analyses showed that lack of joint planning with the relationship partner was associated with a 19% increase in the odds of divorce, even when controlling for various demographic (i.e., age, gender, relationship length, number of children in the household), individual (i.e., neuroticism, positive affect, negative affect, physical symptoms, planning), and relationship (i.e., marital empathy, partner strain, partner disagreement, marital satisfaction, commitment). These results demonstrate the importance of considering one’s partner when making decisions and plans for the future, given that it has clear implications for relationship dissolution. PMID:27668863

  19. Mining injuries in Serbian underground coal mines -- a 10-year study.

    PubMed

    Stojadinović, Saša; Svrkota, Igor; Petrović, Dejan; Denić, Miodrag; Pantović, Radoje; Milić, Vitomir

    2012-12-01

    Mining, especially underground coal mining, has always been a dangerous occupation. Injuries, unfortunately, even those resulting in death, are one of the major occupational risks that all miners live with. Despite the fact that all workers are aware of the risk, efforts must be and are being made to increase the safety of mines. Injury monitoring and data analysis can provide us with valuable data on the causes of accidents and enable us to establish a correlation between the conditions in the work environment and the number of injuries, which can further lead to proper preventive measures. This article presents the data on the injuries in Serbian coal mines during a 10-year period (2000-2009). The presented results are only part of an ongoing study whose aim is to assess the safety conditions in Serbian coal mines and classify them according to that assessment.

  20. A 10-year analysis of rearrests among a cohort of domestic violence offenders.

    PubMed

    Richards, Tara N; Jennings, Wesley G; Tomsich, Elizabeth; Gover, Angela

    2014-01-01

    In this study, survival analysis is used to examine time to rearrest for both domestic violence and nondomestic violence crimes among a cohort of domestic violence offenders (N = 286) over a 10-year period. In addition, risk factors for rearrest such as demographic, offending history, and batterer treatment variables are examined to determine their influence on domestic and nondomestic violence recidivism. Overall, the results suggest that approximately half of domestic violence offenders are rearrested. Furthermore, among those who are rearrested, they are rearrested fairly quickly and for generalized (both domestic and nondomestic violence offenses) versus specialized offending. Risk factors associated with both types of rearrest included age, marriage, and domestic violence offense history. Several additional risk factors were unique to rearrest type. Study limitations are explicitly stated and policy implications are discussed.

  1. Diagnostic Approach to Childhood-onset Cerebellar Atrophy: A 10-Year Retrospective Study of 300 Patients

    PubMed Central

    Al-Maawali, Almundher; Blaser, Susan; Yoon, Grace

    2013-01-01

    Hereditary ataxias associated with cerebellar atrophy are a heterogeneous group of disorders. Selection of appropriate clinical and genetic tests for patients with cerebellar atrophy poses a diagnostic challenge. Neuroimaging is a crucial initial investigation in the diagnostic evaluation of ataxia in childhood, and the presence of cerebellar atrophy helps guide further investigations. We performed a detailed review of 300 patients with confirmed cerebellar atrophy on magnetic resonance imaging over a 10-year period. A diagnosis was established in 47% of patients: Mitochondrial disorders were most common, followed by the neuronal ceroid lipofuscinoses, ataxia telangectasia, and late GM2-gangliosidosis. We review the common causes of cerebellar atrophy in childhood and propose a diagnostic approach based on correlating specific neuroimaging patterns with clinical and genetic diagnoses. PMID:22764178

  2. Epicormic branching on Central Appalachian hardwoods 10 years after deferment cutting. Forest Service research paper

    SciTech Connect

    Miller, G.W.

    1996-03-01

    Epicormic branching as monitored over a 10-year period following deferment cutting in four central Appalachian hardwood stands in West Virginia. Data from 545 codominant residual trees indicated that the average number of epicormic branches on the butt and second 16-food log sections increased significantly for the first 2 years after treatment. For upper log sections of basswood, northern red oak, and black cherry, significant increases continued from the second to the tenth year. The net effect on quality was that 11 percent of residual trees exhibited a reduction in butt-log grade due to epicormic branching. Of the few grade reductions observed, white oak, northern red oak, and black cherry were the most susceptible. Less than 1 percent of yellow-poplar trees had lower grades due to epicormic branching.

  3. Imposex still evident in eastern Australia 10 years after tributyltin restrictions.

    PubMed

    Gibson, Craig P; Wilson, Scott P

    2003-03-01

    A survey of imposex in Thais orbita (Neogastropoda) along the New South Wales (NSW) coast, Australia, found imposex was still widespread 10 years after a partial ban on tributyltin (TBT) based antifouling paints. Transplant experiments also revealed that imposex was induced in T. orbita over a period of 9 weeks in Sydney Harbour, NSW. A comparison of the imposex data with that collected shortly after the introduction of restrictions on TBT revealed a general decline in imposex frequency occurring at open coast sites, an exception being the site at South West Rocks. Sites located within harbour/bay areas did not display a decline in imposex frequency but a decline in the severity of imposex was apparent. The observed decrease in imposex values in T. orbita may reflect a general decrease of butyltin contamination within the coastal environment. However, the persistence of contamination "hotspots" within harbours and bays remains a concern.

  4. Chest CT Manifestations in Children with CVID: A 10-Year Report.

    PubMed

    Boloursaz, Mohammad Reza; Khalilzadeh, Soheila; Nezhad, Pegah Rahmati; Karam, Mehrdad Bakhshayesh; Mahdaviani, Alireza; Mosadegh, Leila; Hassanzad, Maryam; Hosseini, Seyed Mohsen Mir

    2012-01-01

    This study aimed at evaluating HRCT pulmonary manifestations in children with Common Variable Immunodeficiency (CVID) hospitalized in the Pediatric Ward of Masih Daneshvari Hospital during a 10-year period. This retrospective study evaluated 25 children hospitalized with the diagnosis of CVID in the Pediatric Ward of Masih Daneshvari Hospital from 2001 to 2011 and their pulmonary HRCT scans were evaluated. The most common pulmonary HRCT findings were lymphadenopathy (66.7%), bronchiectasis (50%), air trapping (33.3%) and peribronchial wall thickening (33.3%). The highest percentage of CT-scan findings was detected in patients aged 13-17 yrs. Most of the pulmonary changes due to CVID are preventable or treatable. Also, it is possible to prevent irreversible complications of disease if it is diagnosed early. Therefore, HRCT is strongly recommended as an accurate and effective method for monitoring and fast recognition of pulmonary manifestations of the disease especially bronchiectasis which is a very common finding indicative of poor prognosis.

  5. A 10-year review of outpatient skin biopsy results and skin cancer subtypes.

    PubMed

    DeMarco, Sebastian S; Vos, Paul; Green, Harris; Defazio, Jennifer; Davis, Natalie; Fiz, Lindsey; Phillips, Charles

    2016-01-15

    The results of skin biopsies over a 10 year period were reviewed from the outpatient dermatology clinic at the Brody School of Medicine in Greenville, North Carolina. This research was conducted because there are very few studies that characterize this information over a long-term horizon. The biopsy rate per patient encounter, the clinical reason for the biopsy, the biopsy outcomes, the distribution of cutaneous malignancies per encounter, and the distribution of the subtypes of basal cell carcinoma, squamous cell carcinoma, and melanoma were analyzed. Biopsy logs from January 1, 2001 to December 31, 2010 were reviewed. Our investigation found that 20% of patient encounters resulted in a biopsy. Of these biopsies, 87.9% were performed to rule out malignancy and 12.1% were completed on patients suspected of having inflammatory skin conditions. The basal cell carcinomas diagnosed in Greenville, NC have more aggressive histologic subtypes compared to other studies, whereas the squamous cell carcinomas and melanomas were less aggressive.

  6. Occupational therapy and the journal citation reports: 10-year performance trajectories.

    PubMed

    Holguin, Jess Anthony

    2009-01-01

    The purpose of this study was to document performance of occupational therapy journals on the metrics of the Journal Citation Reports (JCR), the annually appearing index used as a yardstick to assess the quality of scholarly publications. Outcomes for the field's two indexed journals, the American Journal of Occupational Therapy and OTJR: Occupation, Participation and Health, were assessed over a 10-year period (1996-2005) to determine their overall standing and patterns of change on each of the JCR's five metrics. The mean category ranking for the two journals was generally above the 50th percentile. However, they performed least adequately and evidenced a downward trend over time on the most widely used metric (the journal impact factor). Possible reasons underlying this latter result are explored, pressing implications of the overall findings for practice and research are discussed, and strategic steps toward ethically safeguarding the profession's viability are offered.

  7. The Effects of Lack of Joint Goal Planning on Divorce over 10 Years.

    PubMed

    Gere, Judith; Almeida, David M; Martire, Lynn M

    Given the negative consequences of divorce on health and well-being, it is important to try to identify its predictors. In the current study we used data from the National Survey of Midlife Development (N = 2801) to examine the longitudinal effects of lack of joint goal planning with a romantic relationship partner on divorce over a 10-year period. Multilevel regression analyses showed that lack of joint planning with the relationship partner was associated with a 19% increase in the odds of divorce, even when controlling for various demographic (i.e., age, gender, relationship length, number of children in the household), individual (i.e., neuroticism, positive affect, negative affect, physical symptoms, planning), and relationship (i.e., marital empathy, partner strain, partner disagreement, marital satisfaction, commitment). These results demonstrate the importance of considering one's partner when making decisions and plans for the future, given that it has clear implications for relationship dissolution.

  8. Injuries in a Professional Ballet Dance Company: A 10-year Retrospective Study.

    PubMed

    Ramkumar, Prem N; Farber, Joseph; Arnouk, Johnny; Varner, Kevin E; Mcculloch, Patrick C

    2016-03-01

    Ballet dancers are high-performance athletes who are particularly susceptible to a wide variety of musculoskeletal injuries. However, they are relatively understudied, and data on their injury rates are lacking. This retrospective study features the largest aggregate data on professional ballet dancers to date and aims to identify the most common diagnoses and areas of injury in this unique population to better direct preventative and clinical practices. The study encompassed a 10-year period from January 2000 to December 2010 of dancers from a single company. Data regarding the dancers' age, gender, location of injury, and diagnosis were collected from workers' compensation claims, company records, and medical records maintained by the treating doctors. These were analyzed to determine metrics on injury incidence, frequency, and diagnosis. Over the 10-year span, 574 injuries occurred. There were approximately 52 dancers per year for a total of 153 who danced at least one complete season during the study period. The average age was 27, and 53% were female. Given turnover with retirement and replacements, the total number of dancer-years was 520, indicating an injury incidence per annum of 1.10 (574 injuries per 520 dancer-years). The most common locations of injury were foot and ankle and the lumbar spine, with the three most common diagnoses making up greater than a third (37%) of the total. As the current largest study in professional ballet, the findings set the benchmark metrics for musculoskeletal injury to the foot, ankle, and lumbar spine sites. Future studies should aim to identify injury risk factors and modalities for prevention of these injuries.

  9. The endonasal microscopic approach for pituitary adenomas and other parasellar tumors: a 10-year experience.

    PubMed

    Fatemi, Nasrin; Dusick, Joshua R; de Paiva Neto, Manoel A; Kelly, Daniel F

    2008-10-01

    THE DIRECT ENDONASAL transsphenoidal approach to the sella with the operating microscope was initially described more than 20 years ago. Herein, we describe the technique, its evolution, and lessons learned over a 10-year period for treating pituitary adenomas and other parasellar pathology. From July 1998 to January 2008, 812 patients underwent a total of 881 operations for a pituitary adenoma (n = 605), Rathke's cleft cyst (n = 59), craniopharyngioma (n = 26), parasellar meningioma (n = 23), chordoma (n = 18), or other pathological condition (n = 81). Of these, 118 operations (13%) included an extended approach to the suprasellar, infrasellar/clival, or cavernous sinus regions. Endoscopic assistance was used in 163 cases (19%) overall, including 36% of the last 200 cases in the series and 18 (72%) of the last 25 extended endonasal cases. Surgical complications included 19 postoperative cerebrospinal fluid leaks (2%), 6 postoperative hematomas (0.7%), 4 carotid artery injuries (0.4%), 4 new permanent neurological deficits (0.4%), 3 cases of bacterial meningitis (0.3%), and 2 deaths (0.2%). The overall complication rate was higher in the first 500 cases in the series and in extended approach cases. Major technical modifications over the 10-year period included increased use of shorter (60-70 mm) endonasal speculums for greater instrument maneuverability and visualization, the micro-Doppler probe for cavernous carotid artery localization, endoscopy for more panoramic visualization, and a graded cerebrospinal fluid leak repair protocol. These changes appear to have collectively and incrementally made the approach safer and more effective. In summary, the endonasal approach provides a minimally invasive route for removal of pituitary adenomas and other parasellar tumors.

  10. Synoptic Monitoring of Water's Return to Mesopotamian Marshlands

    NASA Astrophysics Data System (ADS)

    Mertes, Leal A. K.

    2004-08-01

    The Mesopotamian Marshlands are a recorded element of Sumerian culture since 5000 B.C., and have withstood multiple impacts over the centuries until the twentieth century development of dams on the Tigris-Euphrates systems and increased water usage in Turkey, Syria, and Iraq increased their vulnerability to human impact. Devastation of >90% of ~20,000 km2 of the marshlands occurred over a remarkably short period of time near the end of the 20th century, when the majority of the area was drained beginning in 1991. The late twentieth century barren landscape showed little hope of a return to its aquatic character until a 2003 military strategy, implemented March through May, resulted in return of water to areas that had not been inundated for >10 years. Ali Shaheen, chief of the Iraqi Irrigation Department in Nasiriyah, reported that the tactic of flooding the marshes was designed to interfere with military advances from the south.

  11. Deaths from pesticide poisoning in South Korea: trends over 10 years.

    PubMed

    Lee, Won Jin; Cha, Eun Shil; Park, Eun Sook; Kong, Kyoung Ae; Yi, Jun Hyeok; Son, Mia

    2009-02-01

    Pesticide poisoning is a major cause of death in the world. The objective of this study was to examine the trends of pesticide poisoning deaths and their epidemiologic characteristics in South Korea. We evaluated the age-standardized mortality rates from pesticide-related deaths (intentional self-poisoning, accidental poisoning, assault, undetermined intent poisoning) in South Korea from 1996 through 2005, using registered death data obtained from the Korea National Statistical Office. The regional rurality index was calculated and correlation analyses were used to estimate the association with pesticide poisoning mortality. The number of pesticide poisoning deaths from 1996 through 2005 was 25,360, which accounted for 58.3% of the total poisoning fatalities. The age-standardized mortality rates by pesticide poisoning significantly increased from 4.42 to 6.42 per 100,000 population, whereas the total death rate was decreased in the same period. Intentional self-poisoning was the majority cause of death from pesticides (84.8% of total pesticide poisoning deaths). The majority of the pesticide poisoning deaths were men, over 50 years old, with education less than middle school, and residing in rural areas. The rate of pesticide poisoning deaths was the highest in the farming period and was significantly correlated with the rurality index of each region. Pesticide poisoning deaths substantially increased during the 10-year study period, and showed demographic, seasonal and regional variations. More intensive intervention efforts to reduce pesticide mortality should become a public health priority in South Korea.

  12. 100% Retention of Snowpack Derived Nitrogen Over 10 Years in High Arctic Tundra

    NASA Astrophysics Data System (ADS)

    Choudhary, S.; Tye, A. M.; Young, S. D.; West, H. M.; Phoenix, G. K.

    2013-12-01

    Tundra ecosystems are susceptible to atmospheric nitrogen (N) deposition, increasing as a result of anthropogenic activities as well as climate change. Depositions that get accumulated within the snowpack during winter months are released in spring during snowmelt, providing a periodic input of reactive N in the melt water to such nutrient limited ecosystems. Identifying ecosystem N retention and allocation and how this change over time is important to understanding the long-term consequences of such N depositions to these ecosystems. We reanalysed 10 years later an atmospheric N deposition study established in Svalbard that in 2001 used 15N isotope tracers to determine the fate of N released from melting snowpack. Applications of 15N (99 atom%) at 0.1 and 0.5 g N m-2 were made immediately after snowmelt in 2001 as either Na15NO3 or 15NH4Cl. These applications were approximately 1 × and 5 × the yearly atmospheric deposition rates. In both the previous short-term (one week to two years after 15N tracer application) and our long-term re-sampling (10 years after 15N tracer application), ~67% of the total applied 15N was retained in the ecosystem, irrespective of the N forms or N dose. This meant the tundra had 100% long-term N retention after initial partitioning, suggesting a highly conservative N cycling. Bryophytes, followed by the organic soil horizon and then the microbial biomass formed the greatest short-term 15N sink. Maximum changes in 15N retention from the short- to long-term were observed in the microbial 15N pools, with ~75% of the 15N in soil located in its biomass during the initial partitioning (July 2001) decreasing to ~17% 10 years later. This indicates significant microbial N turnover mostly into stable humus N. In contrast, vascular plants, particularly Salix polaris, showed significant increases (~60%) in their 15N retention after 10 years, indicating a high capacity for acting as a long-term N sink in this tundra ecosystem. Because the largest

  13. Tatanka Returns.

    ERIC Educational Resources Information Center

    Simonelli, Richard

    1993-01-01

    Describes efforts of the InterTribal Bison Cooperative (Rapid City, SD) to reintroduce the buffalo for cultural purposes to American Indian reservations. Explains how the buffalo's return is contributing to community wellness. Discusses career opportunities for both Native and non-Native people in buffalo management. (LP)

  14. Declining Returns.

    ERIC Educational Resources Information Center

    Rosen, Gerald H.; Perrin, Robert

    1992-01-01

    The Teachers Insurance and Annuities Association's (TIAA) College Retirement and Equity Fund is criticized for its low returns and its chief executive officer's recent salary raise. It is said to be in need of additional regulation and policyholder involvement. A TIAA vice president responds that the analysis given is inaccurate and misleading.…

  15. Tatanka Returns.

    ERIC Educational Resources Information Center

    Simonelli, Richard

    1993-01-01

    Describes efforts of the InterTribal Bison Cooperative (Rapid City, SD) to reintroduce the buffalo for cultural purposes to American Indian reservations. Explains how the buffalo's return is contributing to community wellness. Discusses career opportunities for both Native and non-Native people in buffalo management. (LP)

  16. Photoselective Vaporization of the Prostate: Long-Term Outcomes and Safety During 10 Years of Follow-Up.

    PubMed

    Yamada, Yasushi; Furusawa, Jun; Sugimura, Yoshiki; Kuromatsu, Isao

    2016-12-01

    To evaluate the long-term outcomes and safety photoselective vaporization of the prostate (PVP). From April 2005 to December 2015, a total of 1154 patients with benign prostatic hyperplasia underwent PVP. The type of Green Light laser was an 80 W potassium-titanyl-phosphate laser and later a 120 W lithium triborate laser. Before and after surgery, the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-voiding volume of residual urine (PVR), prostate-specific antigen (PSA) level, and prostate volume were assessed regularly. After surgery, events such as second PVP, transurethral incision, and permanent urethral catheterization were defined as retreatment. The mean and median periods of follow-up after PVP were 35.4 and 24.0 months, respectively. The maximum duration of follow-up was 125 months. Compared with before surgery, the IPSS, quality of life score, and PSA concentration improved significantly, even at 10 years after PVP; however, Qmax and PVR were not improved at 10 years. The retreatment-free survival rate was 93.9% at 5 years and 79.0% at 10 years. Prostate cancer was found in 27 cases after PVP, and all patients who were found to have prostate cancer remained alive. Prostate cancer-free survival after PVP was 96.7% at 5 years and 89.4% at 10 years. Our data suggest that the efficacy of PVP was maintained for 10 years; however, it may decrease after more than 10 years. PVP also did not promote the progression of or worsen the prognosis of prostate cancer.

  17. 27 CFR 40.355 - Return of manufacturer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., a semimonthly tax return on TTB Form 5000.24. A return shall be filed for each semimonthly return... for that particular return period. (b) Waiver from filing. The manufacturer need not file a return for... period and the appropriate TTB officer has granted a waiver from filing in response to a written...

  18. Radial growth of grand fir and Douglas-fir 10 years after defoliation by the Douglas-fir tussock moth in the Blue Mountains outbreak.

    Treesearch

    Boyd E. Wickman

    1986-01-01

    Radial-growth recovery related to amount of tree defoliation was measured 10 years after a severe outbreak of Douglas-fir tussock moth (Orgyia pseudotsugata (McDunnough). For the period 1978-82, growth of qrand fir surpassed and was significantly greater than in the preoutbreak period, 1968-72. Douglas-fir growth during the postoutbreak period...

  19. 26 CFR 31.6694-4 - Extension of period of collection when tax return preparer pays 15 percent of a penalty for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE EMPLOYMENT TAXES AND COLLECTION OF INCOME TAX AT SOURCE Administrative Provisions of Special Application to Employment Taxes... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Extension of period of collection when tax...

  20. The Mataró Stroke Registry: a 10-year registry in a community hospital.

    PubMed

    Palomeras Soler, E; Fossas Felip, P; Casado Ruiz, V; Cano Orgaz, A; Sanz Cartagena, P; Muriana Batiste, D

    2015-06-01

    A prospective stroke registry leads to improved knowledge of the disease. We present data on the Mataró Hospital Registry. In February-2002 a prospective stroke registry was initiated in our hospital. It includes sociodemographic data, previous diseases, clinical, topographic, etiological and prognostic data. We have analyzed the results of the first 10 years. A total of 2,165 patients have been included, 54.1% male, mean age 73 years. The most frequent vascular risk factor was hypertension (65.4%). Median NIHSS on admission: 3 (interquartile range, 1-8). Stroke subtype: 79.7% ischemic strokes, 10.9% hemorrhagic, and 9.4% TIA. Among ischemic strokes, the etiology was cardioembolic in 26.5%, large-vessel disease in 23.7%, and small-vessel in 22.9%. The most frequent topography of hemorrhages was lobar (47.4%), and 54.8% were attributed to hypertension. The median hospital stay was 8 days. At discharge, 60.7% of patients were able to return directly to their own home, and 52.7% were independent for their daily life activities. After 3 months these percentages were 76.9% and 62.9%, respectively. Hospital mortality was 6.5%, and after 3 months 10.9%. Our patient's profile is similar to those of other series, although the severity of strokes was slightly lower. Length of hospital stay, short-term and medium term disability, and mortality rates are good, if we compare them with other series. Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved.

  1. Absent menstrual periods - secondary

    MedlinePlus

    Amenorrhea - secondary; No periods - secondary; Absent periods - secondary; Absent menses - secondary; Absence of periods - secondary ... bleeding. When they stop taking these hormones, their periods may not return for more than 6 months. ...

  2. Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience.

    PubMed

    Chang, Jae Won; Hong, Hyun Jun; Ban, Myung Jin; Shin, Yoo Seob; Kim, Won Shik; Koh, Yoon Woo; Choi, Eun Chang

    2015-12-01

    To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value. Retrospective case series with chart review. Academic care center. Ninety-eight patients with primary parotid gland cancer who were surgically treated at Yonsei University Head & Neck Cancer Clinic between January 1999 and December 2008 were analyzed. Patient data were collected retrospectively from medical charts. The investigators analyzed the association of clinicopathological factors and maximum standardized uptake value on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scan with disease-specific survival. Mean patient age was 49.7 years. Mean follow-up was 48.8 months. Thirty-three, 40, 30, and 23 patients had stage I, II, III, and IVA disease, respectively. Mucoepidermoid carcinoma was the most common histologic type (34.7%), followed by acinic cell carcinoma (27.6%). Eighteen patients (18.4%) experienced recurrences (mean recurrence gap, 20.6 months; range, 2-87 months). Five- and 10-year disease-specific survival rates were 93.6% and 81.8%, respectively. In the univariate analysis, pathologic T stage, pathologic lymph node status, resection margin, external parenchymal extension, and maximum standardized uptake value were significantly associated with disease-specific survival. Pathologic lymph node status and maximum standardized uptake value were independent prognostic factors in the multivariate analysis. Our single-center experience with parotid gland cancer treatment is consistent with the literature. Cervical lymph node metastasis and high maximum standardized uptake value are associated with poor survival in parotid gland cancer. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  3. Changes in Neuropsychological Functioning over 10 Years Following Adolescent Substance Abuse Treatment

    PubMed Central

    Hanson, Karen L.; Cummins, Kevin; Tapert, Susan F.; Brown, Sandra A.

    2011-01-01

    Previously, Anderson, Ramo, Cummins, and Brown (2010) described six distinct patterns of alcohol and other drug (AOD) use during the decade following adolescents’ treatment for alcohol and other substance use disorders (A/SUD). This time period represents a phase of significant neurodevelopment and the influence of substance use on the brain is a concern. In the present study we examined patterns of neuropsychological function over these 10 years in relation to the AOD trajectories identified for youth as they transition into their twenties. Participants were part of a longitudinal research project following adolescents with and without A/SUD who received neuropsychological examinations at baseline and up to 7 times thereafter spanning 10 years (N=213; 46% female at baseline). Neuropsychological trajectories were significantly related to substance involvement patterns over time on measures of verbal learning and memory (ps=.011 to <.0001), visuospatial memory (p=.0002), and verbal attention/working memory (p=.020), with heavier use patterns generally followed by poorer cognition. Heavy use of alcohol alone was independently associated with poorer verbal memory over time. Further, substance withdrawal symptoms during each follow-up time point were related to poorer verbal learning and memory scores (ps<.05), while substance abuse/dependence diagnostic criteria were not related to neuropsychological performance levels. These findings suggest that AOD use during adolescence and young adulthood may primarily influence performance that relies on later maturing brain structures, although further research is needed. Higher levels of AOD withdrawal symptoms may signify greater neuropsychological impairment, reflecting potential neurotoxic effects of AOD use. PMID:21443308

  4. Myocardial infarction in Singapore: a nationwide 10-year study of multiethnic differences in incidence and mortality.

    PubMed

    Tan, A T H; Emmanuel, S C; Tan, B Y; Teo, W S; Chua, T S J; Tan, B H

    2002-07-01

    Cardiovascular diseases have progressively increased in importance as a major contributor of morbidity and mortality in Asia. However, many countries in Asia do not have nationwide systematically-collected and standardised data on myocardial infarction (MI). To accurately document the extent of atherosclerotic coronary heart disease in Singapore, a nationwide myocardial infarct registry was established in the mid-1986. Possible myocardial infarct events were identified through daily national lists of cardiac enzymes, hospital discharge codes, mortuary records and the national death registry. Data obtained from clinical history, cardiac enzymes and 12-lead electrocardiogram Minnesota codes were entered into an algorithm based on the WHO MONICA study. Cases identified as "definite" MI were included in the decade's review for this study. From 1988 to 1997, 13,048 myocardial infarct events were diagnosed with 3367 deaths. There was a 39.1% decline in mortality, with an average decline of 6.5% per year [95% confidence intervals (CI), -3.9% to -9.1%]. However, the decline in incidence was only 20.8% with an average decline of 2.4% per year (95% CI, -6.6% to -1.2%). The highest incidence and mortality rates for both genders were seen in the Indians, followed by the Malays and the Chinese. Over 10 years, from 1988 to 1997, we documented a significant fall in mortality from MI in Singapore. There was a smaller decline in the incidence of infarction. Singapore implemented a National Healthy Lifestyle Programme in 1992 as a 10-year effort. The disparity in the incidence and mortality may suggest that a more dramatic and immediate impact has taken place in mortality through therapeutic programmes; primary preventive programmes would be more difficult to evaluate and have a more gradual impact. Only with continual accurate data collection through the whole country, over a much longer period, can the relative value of preventive and therapeutic programmes in coronary heart

  5. A 10-year retrospective review of Salmonella infections at the Children's Hospital in London, Ontario.

    PubMed

    Cellucci, Tania; Seabrook, Jamie A; Chagla, Yasmine; Bannister, Susan L; Salvadori, Marina I

    2010-01-01

    To describe Salmonella infections in children presenting to the Children's Hospital (London Health Sciences Centre, London, Ontario), to assess risk factors for infection and to examine whether younger children, particularly infants younger than 12 weeks of age, experience higher morbidity than older children. A 10-year retrospective review of children with Salmonella infections at the Children's Hospital was conducted. Patient demographics, risk factors for infection, clinical characteristics, bacteriology and outcome were collected from the hospital charts and laboratory records. Data were separated into groups based on age and recent use of antibiotics to analyze differences in outcomes. Sixty-six children with Salmonella infections presented to the Children's Hospital over a 10-year period. Common risk factors for Salmonella infection included having sick contacts, living in a rural area, recent travel, contact with pets (especially reptiles) and exposure to local water. Younger age was associated with an increased likelihood of admission to hospital, treatment with antibiotics and a longer course of antibiotic therapy. This was true when comparing older infants with those younger than 12 weeks of age. Patients recently treated with antibiotics and those with significant underlying medical conditions were more likely to be admitted. A wider knowledge of the epidemiological risk factors for Salmonella infection may improve diagnosis. Higher admission rates were expected in children younger than 12 weeks of age, those recently treated with antibiotics and those who had a significant underlying medical condition. A prospective, multicentre study is needed to further address questions regarding increased illness severity and appropriate management of Salmonella infections in children younger than 12 weeks of age.

  6. Breastfeeding Knowledge and Attitudes of Nevada Health Care Professionals Remain Virtually Unchanged over 10 Years.

    PubMed

    Sigman-Grant, Madeleine; Kim, Yaebin

    2016-05-01

    It is prudent that health care professionals remain cognizant of breastfeeding-related issues to support nursing mothers. In 1995, Freed and colleagues noted deficits in breastfeeding knowledge among family medicine, pediatric, and obstetrics/gynecology residents and practitioners. Others reported similar findings despite calls to action and reports of successful breastfeeding interventions. This retrospective study compared baseline breastfeeding knowledge and attitude scores from Nevada health care professionals from 2004 through 2013. In-training and practicing professionals (pediatric/family practice/obstetric residents and attending physicians; hospital nursing staff; nursing and medical students) attended a 90-minute workshop at their sites. Following each session, attendees voluntarily completed a survey consisting of 2 knowledge and 2 attitudinal questions, using the post:pre-evaluation method, which diminishes overinflation of pretest scores as respondents can more accurately reflect their baseline levels. A Kruskal-Wallis test evaluated differences in baseline knowledge and attitude scores among 3 professional groups and for physicians over the 10-year period using Bonferroni post-hoc analyses. A total of 889 professionals participated, with only physicians represented yearly. Except for knowledge of milk production, physician median baseline scores did not differ significantly over time. Overall, hospital nurses had significantly higher median baseline knowledge scores about initiation and frequent feeding than physicians and students. Nurses also had higher median attitude scores (likelihood of and confidence in talking with parents about breastfeeding) than physicians who had higher scores than students. Despite growing societal enthusiasm and support, the baseline knowledge of and attitudes toward breastfeeding showed minimal change over 10 years. © The Author(s) 2015.

  7. Interactions of borderline personality disorder and anxiety disorders over 10 years.

    PubMed

    Keuroghlian, Alex S; Gunderson, John G; Pagano, Maria E; Markowitz, John C; Ansell, Emily B; Shea, M Tracie; Morey, Leslie C; Sanislow, Charles; Grilo, Carlos M; Stout, Robert L; Zanarini, Mary C; McGlashan, Thomas H; Skodol, Andrew E

    2015-11-01

    This report examines the relationship of DSM-IV borderline personality disorder (BPD) to anxiety disorders using data on the reciprocal effects of improvement or worsening of BPD and anxiety disorders over the course of 10 years. We reliably and prospectively assessed borderline patients (n = 164) with DSM-IV-defined co-occurring generalized anxiety disorder (GAD; n = 42), panic disorder with agoraphobia (n = 39), panic disorder without agoraphobia (n= 36), social phobia (n = 48), obsessive-compulsive disorder (OCD; n = 36), and posttraumatic stress disorder (PTSD; n = 88) annually over a period of 10 years between 1997 and 2009. We used proportional hazards regression analyses to assess the effects of monthly improvement or worsening of BPD and anxiety disorders on each other's remission and relapse the following month. BPD improvement significantly predicted remission of GAD (hazard ratio [HR] = 0.65, P <.05) and PTSD (HR = 0.57, P < .05), whereas BPD worsening significantly predicted social phobia relapse (HR = 1.87, P < .05). The course of anxiety disorders did not predict BPD remission or relapse, except that worsening PTSD significantly predicted BPD relapse (HR = 1.90, P < .05). BPD negatively affects the course of GAD, social phobia, and PTSD. In contrast, the anxiety disorders, aside from PTSD, had little effect on BPD course. For GAD and social phobia, whose course BPD unidirectionally influences, we suggest prioritizing treatment for BPD, whereas BPD should be treated concurrently with panic disorders, OCD, or PTSD. We discuss state/trait issues in the context of our findings. © Copyright 2015 Physicians Postgraduate Press, Inc.

  8. [Analysis on characteristics of red tide in Fujian coastal waters during the last 10 years].

    PubMed

    Li, Xue-Ding

    2012-07-01

    There were 161 red tide events collected during the last 10 years from 2001 to 2010 in Fujian coastal waters. Comprehensive analysis was performed using statistical methods and the results indicated the following characteristics of the temporal and spatial distribution of red tide in Fujian coastal waters: (1) Outbreaks of red tide often occurred between April and September, and the peak period was in May and June. Most red tide events lasted for 2 to 4 days, and the affected area was below 50 square kilometers. The first outbreak of red tide tended to occur earlier in recent years, and the lasting time became longer. (2) There were 20 species of organisms causing the red tides in Fujian coastal waters, among which 10 species were Bacillariophyta, 9 species were Dinophyta and 1 species was Protozoa. Prorocentrum donghaiense was the most frequent cause of red tides, followed by Noctiluca scintillans, Skeletonema costatum and Chaetoceros sp.. The species caused red tides obeyed the succession law and there were always new species involved. (2) In terms of spatial distribution, outbreaks of red tides mainly occurred in the coastal waters of Ningde, Fuzhou and Xiamen. The species causing red tides were Prorocentrum donghaiense and Noctiluca in the coastal waters in the north of Pingtan, Fujian Province, Skeletonema costatum and Chaetoceros in the coastal waters in the south of Pingtan, Fujian Province. The comprehensive analysis of the characteristics of red tides during the last 10 years is expected to provide scientific and reasonable basis for the prevention, reduction and forecast of red tides in Fujian coastal waters.

  9. Feasibility and Use of the Mobile Food Record for Capturing Eating Occasions among Children Ages 3–10 Years in Guam

    PubMed Central

    Aflague, Tanisha F.; Boushey, Carol J.; Leon Guerrero, Rachael T.; Ahmad, Ziad; Kerr, Deborah A.; Delp, Edward J.

    2015-01-01

    Children’s readiness to use technology supports the idea of children using mobile applications for dietary assessment. Our goal was to determine if children 3–10 years could successfully use the mobile food record (mFR) to capture a usable image pair or pairs. Children in Sample 1 were tasked to use the mFR to capture an image pair of one eating occasion while attending summer camp. For Sample 2, children were tasked to record all eating occasions for two consecutive days at two time periods that were two to four weeks apart. Trained analysts evaluated images. In Sample 1, 90% (57/63) captured one usable image pair. All children (63/63) returned the mFR undamaged. Sixty-two children reported: The mFR was easy to use (89%); willingness to use the mFR again (87%); and the fiducial marker easy to manage (94%). Children in Sample 2 used the mFR at least one day at Time 1 (59/63, 94%); Time 2 (49/63, 78%); and at both times (47/63, 75%). This latter group captured 6.21 ± 4.65 and 5.65 ± 3.26 mean (±SD) image pairs for Time 1 and Time 2, respectively. Results support the potential for children to independently record dietary intakes using the mFR. PMID:26043037

  10. Practice of pathological examinations in stillbirths: A 10-year retrospective study.

    PubMed

    Jones, F; Thibon, P; Guyot, M; Molin, A; Jeanne-Pasquier, C; Guillois, B; Benoist, G; Deyfus, M

    2016-12-15

    To describe the practice of fetal and placental pathological examinations in a large series of spontaneous stillbirths over 10 years. Inclusion of cases recorded by the Lower Normandy Regional Fetal-Infant Mortality Observatory (observatoire régional de mortalité fœto-infantile) from January 1, 2005 to December 31, 2014. The possible cause of death was coded in accordance with the ReCoDe classification system. Seven hundred and forty-four cases were recorded. The placental examinations were conducted in 93.7% of cases (CI95%[91.7-95.3]), increasing over the study period, and an autopsy was proposed in 87.2% of cases (CI95%[84.8-89.6]). Autopsy was conducted less frequently during the most recent period, with parental refusal increasing over time. In multivariate analysis, no factor was associated with a higher frequency of placental examinations, while autopsy was proposed more often under certain circumstances: less than 4 pregnancies (P<10(-2)), birth weight from 1000 to 1500 grams (P=0.05), singleton (P<10(-2)), clinical context not suggesting a cause (P<10(-3)), type 1 or 2 maternity ward (P<10(-2)), antepartum death (P<10(-3)). Placental analysis was almost systematically realized, as suggested by international guidelines. Fetal autopsy was often performed, however only in some specific circumstances. New practice guidance to realize customized fetal autopsies appear to be necessary. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  11. Practice of pathological examinations in stillbirths: A 10-year retrospective study.

    PubMed

    Jones, F; Thibon, P; Guyot, M; Molin, A; Jeanne-Pasquier, C; Guillois, B; Benoist, G; Dreyfus, M

    2017-01-01

    To describe the practice of fetal and placental pathological examinations in a large series of spontaneous stillbirths over 10 years. Inclusion of cases recorded by the Lower Normandy Regional Fetal-Infant Mortality Observatory (observatoire régional de mortalité fœto-infantile) from January 1, 2005 to December 31, 2014. The possible cause of death was coded in accordance with the ReCoDe classification system. Seven hundred and forty-four cases were recorded. The placental examinations were conducted in 93.7% of cases (CI95%[91.7-95.3]), increasing over the study period, and an autopsy was proposed in 87.2% of cases (CI95%[84.8-89.6]). Autopsy was conducted less frequently during the most recent period, with parental refusal increasing over time. In multivariate analysis, no factor was associated with a higher frequency of placental examinations, while autopsy was proposed more often under certain circumstances: less than 4 pregnancies (P<10(-2)), birth weight from 1000 to 1500 grams (P=0.05), singleton (P<10(-2)), clinical context not suggesting a cause (P<10(-3)), type 1 or 2 maternity ward (P<10(-2)), antepartum death (P<10(-3)). Placental analysis was almost systematically realized, as suggested by international guidelines. Fetal autopsy was often performed, however only in some specific circumstances. New practice guidance to realize customized fetal autopsies appear to be necessary. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  12. Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center

    PubMed Central

    2017-01-01

    The common causes of postmenopausal bleeding (PMB), according to the data from the western world, are atrophy, hormone replacement therapy (HRT), endometrial cancer, etc. We conducted a retrospective study to assess whether the causes of PMB in Korean postmenopausal women are similar to those already known. This retrospective study used 10-year medical records (March 2005 to December 2014) of 792 PMB women in the Yonsei University Health System. The data were divided into 2 categories by 5-year intervals to compare the differences between the 2 periods. The most common cause of PMB in Korean women was atrophy (51.1%). Polyps and HRT were the second, followed by anticoagulant medications, cervical cancer, and endometrial cancer. The proportion of patients with cervical cancer significantly decreased during the second half of the decade (8.7% vs. 5.2%; P = 0.048). Although no significant change was noted for HRT, its rank was higher during the latter 5-year period. Only the most common cause of PMB was the same as the conventional data. Interestingly, the proportion of patients with cervical cancer decreased during the latter half of the decade, reflecting the changes in the nation's cancer prevalence rate, while the use of HRT increased. PMID:28378558

  13. Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center.

    PubMed

    Kim, Min Kyoung; Jung, Yeon Soo; Chon, Seung Joo; Yun, Bo Hyon; Cho, Sihyun; Choi, Young Sik; Lee, Byung Seok; Seo, Seok Kyo

    2017-05-01

    The common causes of postmenopausal bleeding (PMB), according to the data from the western world, are atrophy, hormone replacement therapy (HRT), endometrial cancer, etc. We conducted a retrospective study to assess whether the causes of PMB in Korean postmenopausal women are similar to those already known. This retrospective study used 10-year medical records (March 2005 to December 2014) of 792 PMB women in the Yonsei University Health System. The data were divided into 2 categories by 5-year intervals to compare the differences between the 2 periods. The most common cause of PMB in Korean women was atrophy (51.1%). Polyps and HRT were the second, followed by anticoagulant medications, cervical cancer, and endometrial cancer. The proportion of patients with cervical cancer significantly decreased during the second half of the decade (8.7% vs. 5.2%; P = 0.048). Although no significant change was noted for HRT, its rank was higher during the latter 5-year period. Only the most common cause of PMB was the same as the conventional data. Interestingly, the proportion of patients with cervical cancer decreased during the latter half of the decade, reflecting the changes in the nation's cancer prevalence rate, while the use of HRT increased. © 2017 The Korean Academy of Medical Sciences.

  14. Trends in Microbiological and Antibiotic Sensitivity Patterns in Infectious Keratitis: 10-Year Experience in Mexico City.

    PubMed

    Hernandez-Camarena, Julio C; Graue-Hernandez, Enrique O; Ortiz-Casas, Mariana; Ramirez-Miranda, Arturo; Navas, Alejandro; Pedro-Aguilar, Lucero; Lopez-Espinosa, Nadia L; Gaona-Juarez, Carolina; Bautista-Hernandez, Luis A; Bautista-de Lucio, Victor M

    2015-07-01

    To report the distribution and trends in microbiological and antibiotic sensitivity patterns of infectious keratitis in a 10-year period at a reference center in Mexico City. In this retrospective observational case series, samples were obtained from corneas with a diagnosis of infectious keratitis from January 2002 to December 2011 at the Institute of Ophthalmology "Conde de Valenciana" in Mexico City. Results of cultures, stains, and specific sensitivity/resistance antibiograms for each microorganism were analyzed. A total of 1638 consecutive corneal scrapings were analyzed. Pathogen was recovered in 616 samples (38%), with bacterial keratitis accounting for 544 of the positive cultures (88%). A nonsignificant increasing trend in gram-negative isolates (P = 0.11) was observed. The most commonly isolated pathogen was Staphylococcus epidermidis, and the most common gram-negative isolated species was Pseudomonas aeruginosa. Methicillin-resistant Staphylococcus aureus (MRSA) was present in 45% of the S. aureus isolates; meanwhile, 53.7% coagulase-negative Staphylococcus isolates were methicillin resistant (MRCNS). Pseudomonas aeruginosa resistance to ceftazidime increased from 15% in the first period to 74% for the last 5 years of the study (P = 0.01). The overall sensitivity for vancomycin of MRSA was 87.5%, whereas 99.6% of the MRCNS were sensitive. There was a nonsignificant increase in the recovered gram-positive and gram-negative microorganisms over time. We observed an increased resistance to methicillin in almost half of the MRSA and MRCNS isolates.

  15. Autism phenotype versus registered diagnosis in Swedish children: prevalence trends over 10 years in general population samples.

    PubMed

    Lundström, Sebastian; Reichenberg, Abraham; Anckarsäter, Henrik; Lichtenstein, Paul; Gillberg, Christopher

    2015-04-28

    To compare the annual prevalence of the autism symptom phenotype and of registered diagnoses for autism spectrum disorder during a 10 year period in children. Population based study. Child and Adolescent Twin Study and national patient register, Sweden. 19, 993 twins (190 with autism spectrum disorder) and all children (n=1,078,975; 4620 with autism spectrum disorder) born in Sweden over a 10 year period from 1993 to 2002. Annual prevalence of the autism symptom phenotype (that is, symptoms on which the diagnostic criteria are based) assessed by a validated parental telephone interview (the Autism-Tics, ADHD and other Comorbidities inventory), and annual prevalence of reported diagnoses of autism spectrum disorder in the national patient register. The annual prevalence of the autism symptom phenotype was stable during the 10 year period (P=0.87 for linear time trend). In contrast, there was a monotonic significant increase in prevalence of registered diagnoses of autism spectrum disorder in the national patient register (P<0.001 for linear trend). The prevalence of the autism symptom phenotype has remained stable in children in Sweden while the official prevalence for registered, clinically diagnosed, autism spectrum disorder has increased substantially. This suggests that administrative changes, affecting the registered prevalence, rather than secular factors affecting the pathogenesis, are important for the increase in reported prevalence of autism spectrum disorder. © Lundström et al 2015.

  16. Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015.

    PubMed

    Atabani, Sowsan F; Wilson, Steven; Overton-Lewis, Clare; Workman, Judith; Kidd, I Michael; Petersen, Eskild; Zumla, Alimuddin; Smit, Erasmus; Osman, Husam

    2016-06-01

    Over 25000 pilgrims from the UK visit Saudi Arabia every year for the Umrah and Hajj pilgrimages. The recent outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea and the continuing reports of MERS-CoV cases from Saudi Arabia highlight the need for active surveillance for MERS-CoV in returning pilgrims or travellers from the Middle East. Public Health England Birmingham Laboratory (PHEBL) is one of a few selected UK public health laboratories responsible for MERS-CoV screening in travellers returning to the UK from the Middle East who present to hospital with severe respiratory symptoms. The results of the PHEBL MERS-CoV screening and surveillance over the past 3 years is presented. UK travellers/pilgrims who returned from the Middle East and presented to a hospital with respiratory symptoms were studied over the period February 1, 2013 to December 31, 2015. Patients with respiratory symptoms, who satisfied the Public Health England MERS-CoV case algorithm, were tested for MERS-CoV and other respiratory tract viruses on admission to hospital. Two hundred and two patients suspected of having MERS-CoV were tested. None of them had a laboratory-confirmed MERS-CoV infection. A viral aetiology was detected in half (50.3%) of the cases, with rhinoviruses, influenza A (H1N1 and H3N2), and influenza B being most frequent. Peak testing occurred following the annual Hajj season and in other periods of raised national awareness. Respiratory tract infections in travellers/pilgrims returning to the UK from the Middle East are mainly due to rhinoviruses, influenza A, and influenza B. Whilst MERS-CoV was not detected in the 202 patients studied, heightened awareness of the possibility of MERS-CoV and continuous proactive surveillance are essential to rapidly identify cases of MERS-CoV and other seasonal respiratory tract viruses such as avian influenza, in patients presenting to hospital. Early identification and isolation may prevent outbreaks in

  17. [Abdominal pain syndrome and quality of life in patients with cholelithiasis after cholecystectomy during a 10-year follow-up].

    PubMed

    Makarova, Yu V; Litvinova, N V; Osipenko, M F; Voloshina, N B

    To estimate the incidence of abdominal pain syndrome (APS) and to assess quality of life (QOL) in patients within 10 years after cholecystectomy (CE). This investigation is part of a long-term prospective follow-up study of patients after CE for cholelithiasis (CL). It enrolled 145 people: 30 (21.5%) patients with baseline asymptomatic CL and 115 (80.7%) with its clinical manifestations. The time course of changes in APS and QOL were analyzed. Over 10 years, all the patients showed a decrease in the incidence of APS from 84.1% (n=95) to 66.4% (n=75; p=0.004). In Group 1 (n=89), APS was at baseline detected in all the patients; 10 years later, its incidence declined to 67.4% (n=60; p < 0.001). Biliary pains were predominant; these had been identified significantly less frequently over the 10-year period in 47 (52.8%) patients; p<0.001). In Group 2 (n=24), pre-CE APS was generally detected in 6 (25%) patients; following 10 years, the incidence rates of pain significantly increased to 62.5% (n=15; p=0.035), among which there were predominant biliary pains (in 54.2%; p<0.001) and dyspepsia from 33.3% (n=8) up to 66.7% (n=16; p=0.039). QOL in the physical and mental health domains was found to decrease in both groups. Ten years after CE, the group with the baseline clinical manifestations of CL and poorer QOL showed a lower incidence of APS mainly due to the reduced incidence of biliary pains and the baseline asymptomatic group exhibited a rise in the incidence of APS due to the appearance of biliary pains and dyspepsia.

  18. Effects of Two Modes of Exercise Training on Physical Fitness of 10 Year-Old Children

    ERIC Educational Resources Information Center

    Ribeiro, Ligia G. dos Santos Chaves; Portal, Maria de Nazare Dias; da Silva, Joao Bittencourt; Saraiva, Alan; da Cruz Monte, Gerson, Jr.; Dantas, Estelio H. M.

    2010-01-01

    Study aim: To compare two exercise training modes on the physical fitness of 10 year-old children. Material and methods: A sample of 60 schoolboys aged 10 years were randomly divided into 3 groups: Traditional (TG), trained according to the Brazilian national curricular parameters, Maturational (MG), in which the degree of difficulty of the…

  19. The Career Trap. Breaking through the 10-Year Barrier To Get the Job You Really Want.

    ERIC Educational Resources Information Center

    Allen, Jeffrey G.

    This book, which is intended for individuals who have been in a job for a decade and feel that their career development has stalled, explains how to break through the 10-year career barrier and get a desired job. The following topics are discussed in the book's 15 chapters: career stalls and their causes; the 10-year career barrier; the legality…

  20. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false 10-year restoration cost-share agreements. 625.9 Section 625.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.9 10-year...

  1. 77 FR 11651 - Hybrid III 10-Year-Old Child Test Dummy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... National Highway Traffic Safety Administration 49 CFR Part 572 RIN 2127-AJ49 Hybrid III 10-Year-Old Child... specifications and qualification requirements for a Hybrid III 10-year- old size child test dummy (HIII-10C). In... Correlates 4. Repeatability in Systems Testing f. Dummy Development Efforts 1. Hybrid III Child Dummy...

  2. The Career Trap. Breaking through the 10-Year Barrier To Get the Job You Really Want.

    ERIC Educational Resources Information Center

    Allen, Jeffrey G.

    This book, which is intended for individuals who have been in a job for a decade and feel that their career development has stalled, explains how to break through the 10-year career barrier and get a desired job. The following topics are discussed in the book's 15 chapters: career stalls and their causes; the 10-year career barrier; the legality…

  3. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false 10-year restoration cost-share agreements. 625.9 Section 625.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.9 10-year...

  4. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false 10-year restoration cost-share agreements. 625.9 Section 625.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.9 10-year...

  5. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false 10-year restoration cost-share agreements. 625.9 Section 625.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.9 10-year...

  6. 7 CFR 625.9 - 10-year restoration cost-share agreements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false 10-year restoration cost-share agreements. 625.9 Section 625.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.9 10-year...

  7. Radial shortening for the treatment of Kienböck's disease--a 5- to 10-year follow-up.

    PubMed

    Almquist, E E; Burns, J F

    1982-07-01

    Kienböck's disease is probably caused by microfractures or stress fractures developing within the lunate. In about 32% of the population, the vascular pattern to the lunate is such that after fracture they are vulnerable to a secondary aseptic necrosis of the lunate. The high incidence of Kienböck's disease in patients with an ulnar minus variant wrist may be explained by an increased stress on the lunate in dorsiflexion and ulnar deviation. This study is a 5- to 10-year follow-up of patients with early stages of Kienböck's disease and ulnar minus variant treated by radial shortening procedures. Eleven of the 12 patients were satisfied with their treatment and showed functional improvement. These patients returned to their normal activities. Grip strength was satisfactory, and range of motion improved following surgery.

  8. Relationship status predicts lower restrictive eating pathology for bisexual and gay men across 10-year follow-up.

    PubMed

    Brown, Tiffany A; Keel, Pamela K

    2015-09-01

    Cross-sectional studies support that bisexual and gay (BG) men are at increased risk for eating pathology, and romantic relationships may buffer against risk; however, no studies have examined this association longitudinally. The current study examined how romantic relationships impact the trajectory of eating pathology in BG versus heterosexual men. BG (n = 51) and heterosexual (n = 522) men completed surveys of health and eating behaviors at baseline and 10-year follow-up. For BG men, being single at baseline prospectively predicted an increase in Drive for Thinness scores over 10-year follow-up. Additionally, for BG men in relationships at baseline, lower relationship satisfaction predicted an increase in Drive for Thinness scores over time. Conversely, these relationship variables did not predict trajectory of eating pathology for heterosexual men. Implications for theoretical models of risk, including objectification theory and sexual minority stress theory, and prevention, including peer-led cognitive dissonance based interventions, are discussed. © 2015 Wiley Periodicals, Inc.

  9. Ecosystem Service Restoration after 10 Years of Rewetting Peatlands in NE Germany

    NASA Astrophysics Data System (ADS)

    Zerbe, Stefan; Steffenhagen, Peggy; Parakenings, Karsten; Timmermann, Tiemo; Frick, Annett; Gelbrecht, Jörg; Zak, Dominik

    2013-06-01

    The restoration of ecosystem services, i.e., production, regulation, and information, is a global challenge, which the federal state of Mecklenburg-Vorpommern in NE Germany addressed in 2000 by rewetting over 20,000 ha of degraded peatlands within the Mire Restoration Program. We evaluated ecosystem services in 23 rewetted sites by assessing the following mire parameters within a ten year period: (a) dominant vegetation at the ecosystem level, (b) peat formation potential at the landscape level, and (c) aboveground biomass and nutrient levels. Seven to 10 years after rewetting, the wetlands formed a mosaic of vegetation types with the highest potential for peat formation and several dominant, peat-forming species accumulated high levels of aboveground biomass and nutrients (C, N, P). Common reed ( Phragmites australis) accumulated the most biomass (up to 24 t dry matter/ha), and N+P during the growing season. A future management option is to annually harvest aquatic and wetland plants to reduce nutrient levels in restored mire ecosystems.

  10. Newspaper Coverage of Autism Treatment in Canada: 10-Year Trends (2004-2013).

    PubMed

    Lanovaz, Marc J; Dufour, Marie-Michèle; Shah, Shalaka

    2015-07-01

    To compare trends in coverage of empirically supported and alternative autism treatments in Canadian newspapers during a 10-year period and to examine whether the portrayal of empirically supported and alternative treatments differed. We searched a sample of 10 daily local and national Canadian newspapers using the word autism combined with intervention or treatment in the Proquest Canadian Newsstand and Eureka.cc databases, which yielded a total of 857 articles published between 2004 and 2013. In our subsequent analyses, we only included articles whose main topic was autism and that referred to at least one treatment. We then categorized the 137 remaining articles by treatment and rated whether each treatment category was portrayed in a favourable, unfavourable, or neutral manner. In total, 46% of the articles discussed at least 1 empirically supported treatment, 53% at least 1 alternative treatment, and 12% at least 1 uncategorized treatment. Newspaper articles provided favourable, unfavourable, and neutral portrayals of empirically supported treatments in 75%, 10%, and 16% of cases, respectively. In contrast, alternative treatments were portrayed favourably in 52%, unfavourably in 32%, and neutrally in 16% of cases. Our analyses indicated that empirically supported treatments were portrayed more favourably than alternative treatments (χ(2) = 10.42, df = 2, P = 0.005). Despite some encouraging trends, our study has shown that researchers and clinicians must continue to clarify misconceptions about autism treatment. Families of people with autism spectrum disorders should be directed toward more reliable and accurate sources of information.

  11. Search and rescue in Yosemite National Park: a 10-year review.

    PubMed

    Hung, Eric K; Townes, David A

    2007-01-01

    To describe the general characteristics and epidemiology of search and rescue (SAR) in Yosemite National Park (YNP) and identify possible areas for intervention directed at reduction in use of these services. Yosemite Search and Rescue (YOSAR) personnel record every search and rescue mission on a Search and Rescue Incident Report. The information contained in these reports was used to perform a retrospective review of all SAR missions within YNP during the 10-year study period between January 1990 and December 1999. YOSAR performed 1912 SAR missions, assisting 2327 individuals and recording 2077 injuries and illnesses. Popular trails in and around Yosemite Valley collectively accounted for 25% of all individuals needing SAR services. Lower extremity injuries and dehydration/hypovolemia/hunger were commonly identified reasons to need SAR services. The duration of SAR missions averaged 5 hours, used 12 SAR personnel, and cost $4400. Helicopter was the primary mode of transport in 28% of SAR incidents. There were 112 fatalities, yielding a SAR case fatality rate of 4.8%. The majority of fatalities occurred while hiking/snowshoeing, with falling the most common mechanism of lethal injury. Day-hikers in and around Yosemite Valley use a large portion of SAR services, with lower extremity injuries and dehydration/hypovolemia/hunger the most common reasons. It seems reasonable to direct future intervention to prevention of these commonly identified problems in this particular population of Park visitors.

  12. The Ecology of Sustainable Implementation: Reflection on a 10-Year Case History Illustration.

    PubMed

    Rimehaug, Tormod

    2014-01-01

    The primary aim of this paper is to illustrate the strategic and ecological nature of implementation. The ultimate aim of implementation is not dissemination but sustainability beyond the implementation effort. A case study is utilized to illustrate these broad and long-term perspectives of sustainable implementation based on qualitative analyses of a 10-year implementation effort. The purveyors aimed to develop selective community prevention services for children in families burdened by parental psychiatric or addictive problems. Services were gradually disseminated to 23 sites serving 40 municipalities by 2013. Up to 2013, only one site terminated services after initial implementation. Although many sites suspended services for shorter periods, services are still offered at 22 sites. This case analysis is based on project reports, user evaluations, practitioner interviews, and service statistics. The paper focuses on the analyses and strategies utilized to cope with quality decay and setbacks as well as progress and success in disseminating and sustaining the services and their quality. Low-cost multilevel strategies to implement services at the community level were organized by a prevention unit in child psychiatry, supervised by a university department (purveyors). The purveyors were also involved in national and international collaboration and development. Multilevel strategies included manualized intervention, in-practice training methods, organizational responsibility, media strategies, service evaluation, staff motivation maintenance, quality assurance, and proposals for new law regulations. These case history aspects will be discussed in relation to the implementation literature, focusing on possible applicability across settings.

  13. An 18-year-old man with recurrent pneumothorax since he was 10-year-old.

    PubMed

    Demir, Meral; Çobanoğlu, Nazan

    2016-12-01

    An 18-year-old male patient was referred to the department of pediatric pulmonology with a history of recurrent pneumothorax. Initial pneumothorax occurred at the age of 10. Following diagnosis of congenital lobar emphysema, he had five episodes of pneumothorax and subsequently underwent right-lower lobe anterobasal segmentectomy. Based on thoracic computed tomography (CT) and clinical manifestation, Birt-Hogg-Dube (BHD) syndrome was suspected and confirmed following genetic testing. BHD syndrome is a rare tumor predisposition syndrome first described in 1977. The syndrome is characterized by skin fibrofolliculomas, lung cysts, recurrent spontaneous pneumothorax, and renal cell cancer. The underlying cause is a germline mutation in the folliculin (FLCN) gene located on chromosome 17p11.2. Clinical manifestation usually appears after the age of 20 years. In this case, we report a case of BHD with episodes of recurrent pneumothorax, the first of which occurred at the age of 10 years. Pulmonologists should be aware of this syndrome in patients with a personal and family history of pneumothoraces and CT findings of multiple pulmonary cysts as additional evaluation and testing may be warranted. Pediatr Pulmonol. 2016;51:E41-E43. © 2016 Wiley Periodicals, Inc.

  14. Fire-related injuries with inpatient care in Finland: a 10-year nationwide study.

    PubMed

    Haikonen, Kari; Lillsunde, Pirjo M; Lunetta, Philippe; Lounamaa, Anne; Vuola, Jyrki

    2013-06-01

    The aim of this study was to examine fire-related injuries leading to inpatient care in Finland. The Finnish National Hospital Discharge Register (2000-2009) and a sample of 222 patients from the Helsinki Burn Centre who sustained flame burns was used. During the 10-years study period, the incidence of fire-related injuries with inpatient care was approximately 5.6 per 100000 persons-years (n=295; males 74%, females 26%). Approximately three quarters involved burns and the remaining cases were mostly combustion gas poisonings. Burns declined from 5.4 in 2000 to 4.0 per 100000 person-years in 2009. The decline was accounted for by young people primarily. Socio-economic features and smoking habits differ between the injured and general population. House fire victims were mainly middle aged and older, while injures involving flammable substances, campfires, etc., were mostly associated with young people. House fires caused the worst damage in terms of Total Body Surface Area burned and inhalation burns. Significantly more people die on the scene of the incident than during the hospital care. Targeting preventive measures in particular at older people and those with a tendency for alcohol abuse and smoking could potentially reduce the burden of the most severe flame burns.

  15. Pregnancies in Women Aged 45 Years and Older - a 10-Year Retrospective Analysis in Berlin.

    PubMed

    Rendtorff, Rosa; Hinkson, Larry; Kiver, Verena; Dröge, Lisa Antonia; Henrich, Wolfgang

    2017-03-01

    Introduction Improved fertility treatment options and a change in the socio-cultural concept of family planning, especially in industrialized regions, has led to an increasing number of births by women of advanced maternal age, which is associated with a higher rate of complications. The aim of this study was to analyze pregnancy outcomes in women aged ≥ 45 years in an inner-city German hospital and to compare these results to those of a younger cohort. Materials and Methods Over a 10-year period from January 2004 to May 2015, the pregnancy outcomes of all 186 women aged ≥ 45 years who delivered in our hospital were compared in a 1 : 1 ratio to those of a cohort of 29-year old women. Results The rates of assisted reproduction (34 vs. 3 %), multiple pregnancies (16 vs. 5 %) and cesarean section (59 vs. 29 %) were significantly increased in the study group. There was an increased risk of preterm delivery (28 vs. 11 %), preeclampsia, gestational diabetes and premature rupture of membranes in the advanced maternal age group. Conclusion Advanced maternal age leads to higher rates of fetal and maternal complications. These findings should be taken into account when planning assisted reproduction and obstetrical care in women with advanced maternal age.

  16. Isolated arthroscopic meniscal repair: a long-term outcome study (more than 10 years).

    PubMed

    Johnson, M J; Lucas, G L; Dusek, J K; Henning, C E

    1999-01-01

    A single surgeon's consecutive series of 50 arthroscopically repaired meniscal tears in 48 patients was retrospectively reviewed. None of these patients had concomitant ligament damage to the knee. The average follow-up period was 10 years, 9 months. Criteria for clinical success included 1) history of pain of grade 1 or less and absence of locking, catching, or giving way; 2) a physical examination demonstrating no significant effusion and a painless and negative jump sign; and 3) no subsequent surgical procedures on the repaired meniscus. Patient satisfaction was quite high, although clinical confirmation was possible in only 38 knees, indicating a clinical success rate of 76%. Bilateral standing radiographs were obtained on these 38 operated knees and were evaluated using Fairbank's classification. Evaluation of the radiographs revealed that 8% of the operated knees had minimal joint changes, as compared with 3% in the contralateral, nonoperated knee. This study demonstrates that arthroscopic meniscal repair in knees with isolated meniscal tears has the potential for a long-term successful clinical and radiographic outcome.

  17. Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old children.

    PubMed

    Whyte, Adrian R; Schafer, Graham; Williams, Claire M

    2016-09-01

    Previously, anthocyanin-rich blueberry treatments have shown positive effects on cognition in both animals and human adults. However, little research has considered whether these benefits transfer to children. Here we describe an acute time-course and dose-response investigation considering whether these cognitive benefits extend to children. Using a double-blind cross-over design, on three occasions children (n = 21; 7-10 years) consumed placebo (vehicle) or blueberry drinks containing 15 or 30 g freeze-dried wild blueberry (WBB) powder. A cognitive battery including tests of verbal memory, word recognition, response interference, response inhibition and levels of processing was performed at baseline, and 1.15, 3 and 6 h following treatment. Significant WBB-related improvements included final immediate recall at 1.15 h, delayed word recognition sustained over each period, and accuracy on cognitively demanding incongruent trials in the interference task at 3 h. Importantly, across all measures, cognitive performance improved, consistent with a dose-response model, with the best performance following 30 g WBB and the worst following vehicle. Findings demonstrate WBB-related cognitive improvements in 7- to 10-year-old children. These effects would seem to be particularly sensitive to the cognitive demand of task.

  18. Impacts of natural hazards on primary health care facilities of iran: a 10-year retrospective survey.

    PubMed

    Ardalan, Ali; Mowafi, Hani; Khoshsabeghe, Homa Yousefi

    2013-06-28

    Public health facilities in Iran are exposed to a wide range of natural hazards. This article presents the first survey of the impacts of such natural hazards on primary health care (PHC) centers in Iran from 2001 to 2011. A retrospective survey was conducted in 25 out of 30 provinces of Iran. Archival reports at provincial public health departments were cross-referenced with key informant interviews. During a 10-year period, 119 natural hazard events were recorded that led to physical damage and/or functional failure in 1,401 health centers, 127 deaths and injury or illness in 644 health staff. Earthquakes accounted for the most physical damage and all health-worker deaths. However, there was an increasing trend of impacts due to hydro-meteorological hazards. Iran's health system needs to establish a registry to track the impact of natural hazards on health facilities, conduct regular hazard and vulnerability assessments and increase mitigation and preparedness measures. Disaster, primary health care, facility, Iran, natural hazard Corresponding author: Ali Ardalan MD, PhD. Iran's National Institute of Health Research, Tehran University of Medical Sciences. Harvard Humanitarian Initiative. Email: aardalan@tums.ac.ir.

  19. Solitary plasmacytoma: 10 years' experience at All India Institute of Medical Sciences, New Delhi.

    PubMed

    Baghmar, Saphalta; Mohanti, Bidhu K; Sharma, Atul; Kumar, Lalit; Prakash, Gaurav; Kumar, Sanjeev; Gupta, Ritu; Kumar, Rajive; Raina, Vinod

    2013-08-01

    Plasma cell dyscrasias account for 1% of all malignancies and 10% of hematological malignancies. About 5% of patients with a plasma cell dyscrasia present with either solitary bone plasmacytoma (SBP) or, less commonly, a soft tissue mass, extramedullary plasmacytoma (EMP) of monoclonal plasma cells. In this study we present the clinical features, management and outcome of 60 patients with solitary plasmacytoma, who constituted 5.6% of 1129 patients with plasma cell dyscrasias treated over a 10-year period at All India Institute of Medical Sciences. Median age was 49 years. Fifty-two had SBP and eight had EMP. Forty-nine (82%) patients received radiotherapy with or without surgical excision or chemotherapy. Five-year event-free survival (EFS) and overall survival (OS) were 45.5% and 91%, respectively. Median EFS and OS were 38 and 122 months, respectively. Five-year survival rates in patients who developed multiple myeloma and those who did not were 81% and 100%, respectively. The median time of progression to myeloma was 21 months.

  20. Breast reconstruction at The Aga Khan University - A 10 year audit.

    PubMed

    Abdullah, Samiullah; Ahsan, Asif; Khan, Tahir Shafi

    2016-10-01

    Considering the high incidence of breast cancer and the subsequent need for a mastectomy, the number of patients having breast reconstruction remains relatively low the world over. Most studies from the west show that anywhere between 5% to around 50% of women proceed to reconstruction following a complete mastectomy. There is a great paucity of literature on the subject in Pakistan. Anecdotal and unofficial accounts would suggest that less than a fraction of 1% of women in Pakistan undergo reconstruction following a mastectomy.We reviewed our cases retrospectively over a 10 year study period from January 2005 to December 2014 with the objective to assess our results and to learn from them as well as to attempt to raise the profile of this important reconstructive manoeuver. Our numbers are low when compared internationally. However on a national level it would seem that the numbers currently exceed most institutions in the country. The overall results appear to be acceptable though the low numbers preclude definitive conclusions.

  1. [Dentoalveolar trauma. Analysis of 4763 patients with 6237 injuries in 10 years].

    PubMed

    Tuli, T; Hächl, O; Rasse, M; Kloss, F; Gassner, R

    2005-09-01

    The purpose of this study was to evaluate the overall place of dental trauma in facial injuries. This was a retrospective investigation based on the analysis of a large amount of dentoalveolar injuries over a 10-year period. Between 1991 and 2000, 4763 of 9543 patients suffering from oral and maxillofacial injuries, sustained dentoalveolar trauma. Records of 6237 different dental injury patterns were reviewed according to the five main injury mechanisms: age, sex, type of injury, cause of accident, and frequency of dentoalveolar trauma. They were statistically analyzed using frequency distribution, chi-square test, t-test, Mann-Whitney U test, Kolmogorov-Smirnov test, and logistic regression analysis. Household and play (2117), sports (1533), traffic accidents (438), acts of violence (426), and work-related accidents (201) were noted. A total of 4763 patients had 2988 subluxations, 2356 showed crown fractures, 444 had avulsions, 176 root fractures, 154 intrusions, and 119 patients suffered from concussions. This number of patients accounts for the prevalence of 49.9% for dentoalveolar trauma among all facial injuries. Only the analysis of a large number of injuries reveals the risk of suffering from dentoalveolar trauma. Due to this fact, preventive methods can be recommended and demanded more effectively.

  2. Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age.

    PubMed

    Danise, P; Maconi, M; Morelli, G; Di Palma, A; Rescigno, G; Esposito, C; Avino, D; Talento, B

    2008-08-01

    Serum transferrin receptor (sTfR) originates mostly from erythroblasts and lesser from reticulocytes. The usefulness of sTfR has been implicated in several clinical situations, mainly as a marker of accelerated erythropoiesis or iron deficiency. The assessment of sTfR may be useful in the period of rapid growth during infancy, childhood and adolescence. We evaluated sTfR and the other quantitative and qualitative parameters of the erythropoiesis (Hb, MCV, CHr, Ret-He) and of the iron storage (serum ferritin, sTfR/ferritin index) in a total of 916 children aged 6-10 years. Children were divided into three groups: (A) healthy children, (B) with storage iron deficiency (serum ferritin < 12 microg/l) and (C) Beta trait carriers (HbA2 > 3.3). We determined reference intervals by sex and by age in healthy children. sTfR showed a slight but statistically significant age related increase but did not show significant sex differences. We compared sTfR and the other parameters investigated in the three groups of children. sTfR is not a decisive parameter that can be utilized alone in discriminating the border-line situations between normal and pathologic ones but can help in completing the panel of tests in iron deficiency and in thalassaemia Beta trait carriers.

  3. Ecosystem service restoration after 10 years of rewetting peatlands in NE Germany.

    PubMed

    Zerbe, Stefan; Steffenhagen, Peggy; Parakenings, Karsten; Timmermann, Tiemo; Frick, Annett; Gelbrecht, Jörg; Zak, Dominik

    2013-06-01

    The restoration of ecosystem services, i.e., production, regulation, and information, is a global challenge, which the federal state of Mecklenburg-Vorpommern in NE Germany addressed in 2000 by rewetting over 20,000 ha of degraded peatlands within the Mire Restoration Program. We evaluated ecosystem services in 23 rewetted sites by assessing the following mire parameters within a ten year period: (a) dominant vegetation at the ecosystem level, (b) peat formation potential at the landscape level, and (c) aboveground biomass and nutrient levels. Seven to 10 years after rewetting, the wetlands formed a mosaic of vegetation types with the highest potential for peat formation and several dominant, peat-forming species accumulated high levels of aboveground biomass and nutrients (C, N, P). Common reed (Phragmites australis) accumulated the most biomass (up to 24 t dry matter/ha), and N+P during the growing season. A future management option is to annually harvest aquatic and wetland plants to reduce nutrient levels in restored mire ecosystems.

  4. Diagnosis and management of ruptured hepatoma: single center experience over 10 years.

    PubMed

    Letchumanan, V P; Lim, K F; Mohamad, A B

    2013-10-01

    Spontaneous rupture is a dramatic presentation of HCC and it carries high mortality rate. To study the outcomes of ruptured HCC patients managed at a tertiary referral centre in Malaysia. A retrospective review of all ruptured HCC patients managed as inpatient at the Department of Hepatobiliary Surgery, Hospital Selayang between January 2001 and December 2010. Data was retrieved from the hospital electronic medical records, Powerchart (Cerner Corporation Inc., USA) and supplemented with registry from Interventional Radiology record of chemoembolization and registry from hepatobiliary operative surgery records. There were 22 patients admitted with confirmed diagnosis of ruptured HCC over 10 years period. The common clinical findings on presentation were abdominal pain and presence of shock (36.4%). The mortality rate was 81.8% with only four patients noted to be alive during the follow up. One year overall survival for ER and DR are 40.0% and 72.7% respectively and the median survival in patients treated with DR was 433.3 days whereas it was 212.5 days in ER group. This study supports the clinical practice of TAE should be the first line treatment followed by staged surgery in suitable candidates with ruptured HCC.

  5. A 10-year systematic review of HIV/AIDS mass communication campaigns: Have we made progress?

    PubMed

    Noar, Seth M; Palmgreen, Philip; Chabot, Melissa; Dobransky, Nicole; Zimmerman, Rick S

    2009-01-01

    The purpose of the current study was to conduct a 10-year systematic review of HIV/AIDS mass communication campaigns focused on sexual behavior, HIV testing, or both (1998-2007) and to compare the results with the last comprehensive review of such campaigns, conducted by Myhre and Flora (2000). A comprehensive search strategy yielded 38 HIV/AIDS campaign evaluation articles published in peer-reviewed journals, representing 34 distinct campaign efforts conducted in 23 countries. The articles were coded on a variety of campaign design and evaluation dimensions by two independent coders. Results indicated that compared with the previous systematic review (1986-1998 period), campaigns increasingly have employed the following strategies: (1) targeted defined audiences developed through audience segmentation procedures; (2) designed campaign themes around behavior change (rather than knowledge change); (3) used behavioral theories; (4) achieved high message exposure; (5) used stronger research designs for outcome evaluation; and (6) included measures of behavior (or behavioral intentions) in outcome assessments. In addition, an examination of 10 campaign efforts that used more rigorous quasi-experimental designs revealed that the majority (8 of 10) demonstrated effects on behavior change or behavioral intentions. Despite these positive developments, most HIV/AIDS campaigns continue to use weak (i.e., preexperimental) outcome evaluation designs. Implications of these results for improved design, implementation, and evaluation of HIV/AIDS campaign efforts are discussed.

  6. Newspaper Coverage of Autism Treatment in Canada: 10-Year Trends (2004–2013)

    PubMed Central

    Lanovaz, Marc J; Dufour, Marie-Michèle; Shah, Shalaka

    2015-01-01

    Objective: To compare trends in coverage of empirically supported and alternative autism treatments in Canadian newspapers during a 10-year period and to examine whether the portrayal of empirically supported and alternative treatments differed. Method: We searched a sample of 10 daily local and national Canadian newspapers using the word autism combined with intervention or treatment in the Proquest Canadian Newsstand and Eureka.cc databases, which yielded a total of 857 articles published between 2004 and 2013. In our subsequent analyses, we only included articles whose main topic was autism and that referred to at least one treatment. We then categorized the 137 remaining articles by treatment and rated whether each treatment category was portrayed in a favourable, unfavourable, or neutral manner. Results: In total, 46% of the articles discussed at least 1 empirically supported treatment, 53% at least 1 alternative treatment, and 12% at least 1 uncategorized treatment. Newspaper articles provided favourable, unfavourable, and neutral portrayals of empirically supported treatments in 75%, 10%, and 16% of cases, respectively. In contrast, alternative treatments were portrayed favourably in 52%, unfavourably in 32%, and neutrally in 16% of cases. Our analyses indicated that empirically supported treatments were portrayed more favourably than alternative treatments (χ2 = 10.42, df = 2, P = 0.005). Conclusions: Despite some encouraging trends, our study has shown that researchers and clinicians must continue to clarify misconceptions about autism treatment. Families of people with autism spectrum disorders should be directed toward more reliable and accurate sources of information. PMID:26175392

  7. Cardiac and great vessel injuries after chest trauma: our 10-year experience.

    PubMed

    Onan, Burak; Demirhan, Recep; Öz, Kürşad; Onan, Ismihan Selen

    2011-09-01

    Cardiovascular injuries after trauma present with high mortality. The aim of the study was to present our experience in cardiac and great vessel injuries after chest trauma. During the 10-year period, 104 patients with cardiac (n=94) and great vessel (n=10) injuries presented to our hospital. The demographic data, mechanism of injury, location of injury, other associated injuries, timing of surgical intervention, surgical approach, and clinical outcome were reviewed. Eighty-eight (84.6%) males presented after chest trauma. The mean age of the patients was 32.5±8.2 years (range: 12-76). Penetrating injuries (62.5%) were the most common cause of trauma. Computed tomography was performed in most cases and echocardiography was used in some stable cases. Cardiac injuries mostly included the right ventricle (58.5%). Great vessel injuries involved the subclavian vein in 6, innominate vein in 1, vena cava in 1, and descending aorta in 2 patients. Early operations after admission to the emergency were performed in 75.9% of the patients. Thoracotomy was performed in 89.5% of the patients. Operative mortality was significantly high in penetrating injuries (p=0.01). Clinicians should suspect cardiac and great vessel trauma in every patient presenting to the emergency unit after chest trauma. Computed tomography and echocardiography are beneficial in the management of chest trauma. Operative timing depends on hemodynamic status, and a multidisciplinary team approach improves the patient's prognosis.

  8. Diagnosis and 10-year follow-up of a community-based hepatitis C cohort.

    PubMed

    Yawn, Barbara P; Wollan, Peter; Gazzuola, Liliana; Kim, W Ray

    2002-02-01

    To determine the health care follow-up and treatment associated with physician-diagnosed hepatitis C (HCV) in a community-based population. We conducted a retrospective medical record review using records from all providers in Olmsted County, Minnesota. The study incorporated all Olmsted County residents with physician-diagnosed hepatitis C from 1990 through 1999. We assessed demographic and health status information as well as health services use in subjects with physician-diagnosed HCV. Physicians diagnosed hepatitis C in 355 subjects (219 men [62%], 136 women [38%]), mean age 43 years, in the 10-year period studied. About half of diagnoses (45%, n = 159) were confirmed with polymerase chain reaction or liver biopsies. Identified risk factors included IV drug use (50%), multiple sex partners (36%), and blood transfusion (30%). Follow-up assessment with aspartate aminotransferase/amino alanine transferase (AST/ALT) tests occurred in about half (49%) of subjects, while 202 subjects (60%) were referred for gastrointestinal (GI) specialist evaluation and 49 patients (14% of all, 25% of those referred to a GI specialist) had specific treatment for hepatitis C. Although well over half of patients (60%) had possible contraindications to HCV treatment, including heavy alcohol use, few were referred for chemical dependency therapy. In this community, follow-up and treatment related to HCV were limited. Attention to prevention of disease-accelerating co- infections was only modest. Referral or documented recommendations for treatment of alcoholism or heavy chronic alcohol ingestion were minimal.

  9. [Peri-viability: limits of prematurity in a regional hospital in the last 10 years].

    PubMed

    Solís Sánchez, G; Pérez González, C; García López, E; Costa Romero, M; Arias Llorente, R P; Suárez Rodríguez, M; Fernández Colomer, B; Coto Cotallo, G D

    2014-03-01

    To determine the preterm viability between 22 and 25 gestational weeks in our hospital in last 10 years. A descriptive retrospective study was conducted on preterms between 22-25 gestational weeks born between 1-1-2002 and 12-31-2011. There were 121 newborns, 45 (37%) stillbirths and 76 (63%) live births (16 died in delivery room, and 60 admitted to neonatal intensive unit). Among the 60 admitted, 34 died before hospital discharge, and 26 survived (21% of total, 34% of live births and 43% of those admitted to neonatal intensive unit). The causes of death were: 16 therapeutic effort limitation in delivery room, 8 therapeutic effort limitation in neonatal ward, 7 nosocomial sepsis, 7 NEC, 4 respiratory problems, and 8 of unknown cause. There were no survivors below 24 gestational weeks. Of the 26 survivors, 4 had major neurological disorders, and 11 with a normal neurological outcome. No significant statistical differences were found in the mortality between the two five-year periods analysed. The peri-viability has important clinical and ethical problems for neonatologist. Copyright © 2012 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  10. Pediatric liver transplantation for acute liver failure at a single center: A 10 year experience

    PubMed Central

    Heffron, TG; Pillen, T; Smallwood, GA; Rodriguez, J; Sekar, S; Henry, S; Vos, M; Casper, K; Gupta, N; Fasola, C; Romero, R

    2014-01-01

    Children transplanted for acute liver failure (ALF) urgently require an optimal graft. Lower post-transplant survival compared to children transplanted for chronic liver disease. Over 10 years, 33 consecutive children transplanted for ALF were followed. Demographics, encephalopathy, intubation, dialysis, laboratory values, graft type (ABO incompatible grafts (ABOI), Large for size grafts(XL)(GRWR>5%),deceased donor segmental liver transplantation(DDSLT), living donor liver transplantation (LDLT) and whole liver transplant (WLT) were evaluated. Complications and survival were determined. ALF accounted for 33/201 (16.4%) of transplants during this period. 12/33 received ABOI, 5 XL grafts, 18 DDSLT, and 3 LDLT. Waiting time pre-transplant was 2.1 days. 1 and 3 year patient survival ALF group was 93% and 93% and graft survivals were 93 and 78.6%. Median follow-up was 1452 days. ABOI one and three year patient and graft survival in the ALF was 92 and 75%. No difference in graft or patient survival was noted in the ALF and chronic liver disease group nor the ABOI and the ABO compatible group. A combination of ABO incompatible donor livers, large for size grafts, DDSLT, LDLT and WLT led to a short wait time and subsequent graft and patient survival not significantly different than that for non-acute liver disease. PMID:19519799

  11. Transition in Dental Treatment Utilization in Jammu And Kashmir, India - A 10 Year Retrospective Study

    PubMed Central

    Batra, Manu; Ishrat, A.

    2016-01-01

    Background: Utilization of health services is the actual attendance by the members of the public at health care facilities to receive care. Utilization, serves as an important tool for oral health policy decision-making. The aim of the present study was to retrospectively gauge and assess the utilization pattern of the dental treatments which was given in hospital for last 10 years. Materials and Methods: This retrospective infirmary based study was carried out at Sheri Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, India. The yearly outpatient department (OPD) records for the utilization of specific dental treatment of a total of 103963 patients were assessed retrospectively from 2014 to 2003. Trend analysis was used to assess the trend of utilization of each speciality with best fitted linear trend lines. Results: The pattern of new patients has also shown a constant rise during the study period except for 2008 and 2009. The utilization of oral surgery speciality has shown a tremendous fall from 2003 to 2014 whereas the number of patients coming to periodontics and conservative dentistry has shown an increasing pattern. Conclusion: Utilization of oral health care has long been used as an indicator of oral health related behaviour of a population. In the present study it can be conclude that the outlook of the population under study has changed from blood and vulcanite dentistry outlook and is moving towards restorative dentistry. . PMID:28804675

  12. Antileprosy measures in Bombay, India: an analysis of 10 years' work*

    PubMed Central

    Koticha, K. K.; Nair, P. R. R.

    1976-01-01

    Leprosy control measures adopted in Bombay consist of health education, case-detection, and treatment, and are carried out mainly by the Acworth Leprosy Hospital and its subsidiary, the Greater Bombay Leprosy Control Scheme. Although the data collected on different aspects of leprosy during the 10-year period 1963-72 are hospital-based and retrospective, their analysis provides a useful indicator of the possible situation in the field. Health education is provided by medical social workers, field staff, and physicians, and the significance of this activity in relation to early detection of leprosy is analysed. It is shown, however, that case-holding is a more urgent priority than case-detection. Trials have confirmed the effectiveness of chemoprophylaxis with dapsone for contacts of infectious index cases in crowded households. Comparison of annual expenditure per outpatient in leprosy clinics with that for inpatients in a leprosy hospital demonstrates greater cost-effectiveness of outpatient treatment. Some practical recommendations are made for leprosy control. PMID:827341

  13. Atmospheric emissions and trends of nitrous oxide deduced from 10 years of ALE-GAGE data

    NASA Technical Reports Server (NTRS)

    Prinn, R.; Cunnold, D.; Alyea, F.; Rasmussen, R.; Simmonds, P.

    1990-01-01

    Long-term measurements of nitrous oxide (N2O) obtained during the Atmospheric Lifetime Experiment (ALE) and the Global Atmospheric Gases Experiment (GAGE) for a period from 1978 to 1988 are presented and interpreted. It is observed that the average concentration in the Northern Hemisphere is 0.75 +/- 0.16 ppbv higher than in the Southern Hemisphere and that the global average linear trend in N2O lies in the range from 0.25 to 0.31 percent/year. The measured trends and latitudinal distributions are shown to be consistent with the hypothesis that stratospheric photodissociation is the major atmospheric sink for N2O, while the cause of the N2O trend is suggested to be a combination of a growing tropical source and a growing Northern mid-latitude source. A 10-year average global N2O emission rate of (20.5 +/- 2.4) x 10 to the 12th g N2O/year is deduced from the ALE/GAGE data.

  14. Impacts of Natural Hazards on Primary Health Care Facilities of Iran: A 10-Year Retrospective Survey

    PubMed Central

    Ardalan, Ali; Mowafi, Hani; Yousefi, Homa

    2013-01-01

    Public health facilities in Iran are exposed to a wide range of natural hazards. This article presents the first survey of the impacts of such natural hazards on primary health care (PHC) centers in Iran from 2001 to 2011. A retrospective survey was conducted in 25 out of 30 provinces of Iran. Archival reports at provincial public health departments were cross-referenced with key informant interviews. During a 10-year period, 119 natural hazard events were recorded that led to physical damage and/or functional failure in 1,401 health centers, 127 deaths and injury or illness in 644 health staff. Earthquakes accounted for the most physical damage and all health-worker deaths. However, there was an increasing trend of impacts due to hydro-meteorological hazards. Iran’s health system needs to establish a registry to track the impact of natural hazards on health facilities, conduct regular hazard and vulnerability assessments and increase mitigation and preparedness measures. Keywords: Disaster, primary health care, facility, Iran, natural hazard Corresponding author: Ali Ardalan MD, PhD. Iran’s National Institute of Health Research, Tehran University of Medical Sciences. Harvard Humanitarian Initiative. Email: aardalan@tums.ac.ir PMID:23863871

  15. Are there any complications with bioabsorbable fixation devices? A 10 year review in orthognathic surgery.

    PubMed

    Laine, P; Kontio, R; Lindqvist, C; Suuronen, R

    2004-04-01

    Bioabsorbable fixation devices have been used in our departments between November 1991 and November 2001 in orthognathic surgery. The aim of this retrospective study was to assess all complications experienced during this time period, when we have operated 163 patients who have undergone 329 orthognathic osteotomies fixated with bioresorbable devices. No postoperative intermaxillary fixation was used. Light guiding elastics were used for 5 to 7 weeks. Patients' acceptance was generally excellent and very few complications occurred during this follow-up of 10 years. The complications were minor and did not affect the end results of the operations. Minor complications occurred in 14 patients (8.6%). Only one patient (0.6%) had a postoperative infection with elevated infection parameters. The other minor complications consisted mainly of dehiscence of the wound and plate exposure together with granulation tissue in the operation field. The rest of the complications occurred in the beginning of our study, when large screw heads on top of the bone irritated the patient and had to be removed. Insufficient fixation resulted in open bite in three patients (1.8%) in the beginning of the trial use of new devices, which no longer are used. Based on our experience, bioresorbable devices are safe to be used in orthognathic procedures. However, there is a learning curve, as there is with all new methods introduced.

  16. Cervical spine injuries from diving accident: a 10-year retrospective descriptive study on 64 patients.

    PubMed

    Chan-Seng, E; Perrin, F E; Segnarbieux, F; Lonjon, N

    2013-09-01

    Ninety percent of the lesions resulting from diving injuries affect the cervical spine and are potentially associated with spinal cord injuries. The objective is to determine the most frequent lesion mechanisms. Evaluate the therapeutic alternatives and the biomechanical evolution (kyphotic deformation) of diving-induced cervical spine injuries. Define epidemiological characteristics of diving injuries. A retrospective analysis over a period of 10 years was undertaken for patients admitted to the Department of Neurosurgery of Montpellier, France, with cervical spinal injuries due to a diving accident. Patients were re-evaluated and clinical and radiological evaluation follow-ups were done. This study included 64 patients. Cervical spine injuries resulting from diving predominantly affect young male subjects. They represent 9.5% of all the cervical spine injuries. In 22% of cases, patients presented severe neurological troubles (ASIA A, B, C) at the time of admission. A surgical treatment was done in 85% of cases, mostly using an anterior cervical approach. This is a retrospective study (type IV) with some limitations. The incidence of diving injuries in our region is one of the highest as compared to reports in the literature. Despite an increase of our surgical indications, 55% of these cases end up with a residual kyphotic deformation but there is no relationship between the severity of late vertebral deformity and high Neck Pain and Disability Scale (NPDS) scores. Level IV, retrospective study. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  17. Group A Streptococcal Carriage and Seroepidemiology in Children up to 10 Years of Age in Australia.

    PubMed

    Marshall, Helen S; Richmond, Peter; Nissen, Michael; Lambert, Stephen; Booy, Robert; Reynolds, Graham; Sebastian, Shite; Pride, Michael; Jansen, Kathrin U; Anderson, Annaliesa S; Scully, Ingrid L

    2015-08-01

    Group A streptococci (GAS) and other β-hemolytic streptococci (BHS) cause pharyngitis, severe invasive disease and serious nonsuppurative sequelae including rheumatic heart disease and post streptococcal glomerulonephritis. The aim of this study was to assess carriage rates and anti-streptococcal C5a peptidase (anti-SCP) IgG levels and identify epidemiologic factors related to carriage or seropositivity in Australian children. A throat swab and blood sample were collected for microbiological and serological analysis (anti-SCP IgG) in 542 healthy children aged 0-10 years. Sequence analysis of the SCP gene was performed. Serological analysis used a competitive Luminex Immunoassay designed to preferentially detect functional antibody. GAS-positive culture prevalence in throat swabs was 5.0% (range 0-10%), with the highest rate in 5 and 9 years old children. The rate of non-GAS BHS carriage was low (<1%). The scp gene was present in all 22 isolates evaluated. As age of child increased, the rate of carriage increased; odds ratio, 1.14 (1.00, 1.29); P = 0.50. Geometric mean anti-SCP titers increased with each age-band from 2 to 7 years, then plateaued. Age, geographic location and number of children within the household were significantly associated with the presence of anti-SCP antibodies. Children are exposed to GAS and other BHS at a young age, which is important for determining the target age for vaccination to protect before the period of risk.

  18. Outcomes of Levator Resection at Tertiary Eye Care Center in Iran: A 10-Year Experience

    PubMed Central

    Bagheri, Abbas; Salour, Hossein; Aletaha, Maryam; Yazdani, Shahin

    2012-01-01

    Purpose To assess outcomes of levator resection for the surgical correction of congenital and acquired upper lid ptosis in patients with fair to good levator function and evaluation of the relationship between demographic data and success of this operation. Methods In a retrospective study, medical records of patients with blepharoptosis who had undergone levator resection over a 10-year period and were followed for at least 3 months were reviewed. Results Overall, 136 patients including 60 (44.1%) male and 76 (55.9%) female subjects with a mean age of 20 ± 13.8 years (range, 2 to 80 years) were evaluated, of whom 120 cases (88.2%) had congenital ptosis and the rest had acquired ptosis. The overall success rate after the first operation was 78.7%. The most common complication after the first operation was undercorrection in 26 cases (19.1%), which was more prevalent among young patients (p = 0.06). Lid fissure and margin reflex distance (MRD1) also increased after levator resection (p < 0.001). Age, sex, type of ptosis, amblyopia, levator function, MRD1, lid fissure and spherical equivalent were not predictive of surgical outcomes of levator resection. Conclusions Levator resection has a high rate of success and few complications in the surgical treatment of congenital and acquired upper lid ptosis with fair to good levator function. Reoperation can be effective in most cases in which levator resection has been performed. PMID:22323877

  19. Surrogacy families 10 years on: relationship with the surrogate, decisions over disclosure and children's understanding of their surrogacy origins

    PubMed Central

    Jadva, V.; Blake, L.; Casey, P.; Golombok, S.

    2012-01-01

    BACKGROUND This study aimed to prospectively examine families created using surrogacy over a 10-year period in the UK with respect to intending parents' and children's relationship with the surrogate mother, parents' decisions over disclosure and children's understanding of the nature of their conception. METHODS Semi-structured interviews were administered by trained researchers to intending mothers, intending fathers and children on four occasions over a 10-year period. Forty-two families (19 with a genetic surrogate mother) participated when the child was 1-year old and by age 10 years, 33 families remained in the study. Data were collected on the frequency of contact with the surrogate mother, relationship with the surrogate, disclosure of surrogacy to the child and the child's understanding of their surrogacy birth. RESULTS Frequency of contact between surrogacy families and their surrogate mother decreased over time, particularly for families whose surrogate was a previously unknown genetic carrier (P < 0.001) (i.e. where they had met through a third party and the surrogate mother's egg was used to conceive the child). Most families reported harmonious relationships with their surrogate mother. At age 10 years, 19 (90%) children who had been informed of the nature of their conception had a good understanding of this and 13 of the 14 children who were in contact with their surrogate reported that they liked her. CONCLUSIONS Surrogacy families maintained good relationships with the surrogate mother over time. Children felt positive about their surrogate mother and their surrogacy birth. The sample size of this study was small and further, larger investigations are needed before firm conclusions can be drawn. PMID:22814484

  20. Surrogacy families 10 years on: relationship with the surrogate, decisions over disclosure and children's understanding of their surrogacy origins.

    PubMed

    Jadva, V; Blake, L; Casey, P; Golombok, S

    2012-10-01

    This study aimed to prospectively examine families created using surrogacy over a 10-year period in the UK with respect to intending parents' and children's relationship with the surrogate mother, parents' decisions over disclosure and children's understanding of the nature of their conception. Semi-structured interviews were administered by trained researchers to intending mothers, intending fathers and children on four occasions over a 10-year period. Forty-two families (19 with a genetic surrogate mother) participated when the child was 1-year old and by age 10 years, 33 families remained in the study. Data were collected on the frequency of contact with the surrogate mother, relationship with the surrogate, disclosure of surrogacy to the child and the child's understanding of their surrogacy birth. Frequency of contact between surrogacy families and their surrogate mother decreased over time, particularly for families whose surrogate was a previously unknown genetic carrier (P < 0.001) (i.e. where they had met through a third party and the surrogate mother's egg was used to conceive the child). Most families reported harmonious relationships with their surrogate mother. At age 10 years, 19 (90%) children who had been informed of the nature of their conception had a good understanding of this and 13 of the 14 children who were in contact with their surrogate reported that they liked her. Surrogacy families maintained good relationships with the surrogate mother over time. Children felt positive about their surrogate mother and their surrogacy birth. The sample size of this study was small and further, larger investigations are needed before firm conclusions can be drawn.

  1. A review of 10 years of scapula injuries sustained by UK military personnel on operations.

    PubMed

    Roberts, Darren C; Power, D M; Stapley, S A

    2017-09-11

    Scapula fractures are relatively uncommon injuries, mostly occurring due to the effects of high-energy trauma. Rates of scapula fractures are unknown in the military setting. The aim of this study is to analyse the incidence, aetiology, associated injuries, treatment and complications of these fractures occurring in deployed military personnel. All UK military personnel returning with upper limb injuries from Afghanistan and Iraq were retrospectively reviewed using the Royal Centre for Defence Medicine database and case notes (2004-2014). Forty-four scapula fractures out of 572 upper limb fractures (7.7%) were sustained over 10 years. Blast and gunshot wounds (GSW) were leading causative factors in 85%. Over half were open fractures (54%), with open blast fractures often having significant bone and soft tissue loss requiring extensive reconstruction. Multiple injuries were noted including lung, head, vascular and nerve injuries. Injury Severity Scores (ISS) were significantly higher than the average upper limb injury without a scapula fracture (p<0.0001). Brachial plexus injuries occurred in 17%. While military personnel with GSW have a favourable chance of nerve recovery, 75% of brachial plexus injuries that are associated with blast have poorer outcomes. Fixation occurred with either glenoid fractures or floating shoulders (10%); these were as a result of high velocity GSW or mounted blast ejections. There were no cases of deep soft tissue infection or osteomyelitis and all scapula fractures united. Scapula fractures have a 20 times higher incidence in military personnel compared with the civilian population, occurring predominantly as a result of blast and GSW, and a higher than average ISS. These fractures are often associated with multiple injuries, including brachial plexus injuries, where those sustained from blast have less favourable outcome. High rates of union following fixation and low rates of infection are expected despite significant contamination

  2. Minimum 10-year follow-up of arthroscopic intra-articular Bankart repair using bioabsorbable tacks.

    PubMed

    Privitera, David M; Bisson, Leslie J; Marzo, John M

    2012-01-01

    There are few long-term studies evaluating functional outcomes and rates of arthrosis after arthroscopic Bankart repair with bioabsorbable tacks. We evaluated the clinical and radiographic results of arthroscopic Bankart repair using intra-articular bioabsorbable tacks at a minimum of 10 years' follow-up. Case series; Level of evidence, 4. Thirty-two consecutive patients were retrospectively identified. Twenty patients (63%) were evaluated at a mean follow-up of 13.5 years (range, 10.75-17.5 years) and average age of 43 years (range, 28-73 years). The surgical shoulder (SS) was compared with a healthy control shoulder (CS) in 15 of 20 patients. Outcome tools included the Western Ontario Shoulder Instability Index (WOSI) and Disabilities of the Shoulder, Arm, and Hand (DASH). Blinded, independent evaluators performed physical examinations and reviewed radiographs. Thirteen patients (65%) had stable shoulders, 5 of 7 (25%) failed by dislocation, and 2 of 7 (10%) failed by signs of anterior instability on examination. Three patients underwent revision stabilization surgery. Average time to failure was 4.2 years (range, 0.25-14.7 years). Average WOSI and DASH scores were 80% and 7.3, respectively. The CS faired better than SS in WOSI scores (97% vs 83%, respectively; P = .008), main DASH scores (0.39 vs 6.79, respectively; P = .024), and the DASH sports module (0.00 vs 10.94, respectively; P = .043). Patients lost 5.9° of passive forward flexion (P = .031) and 4.3° of passive external rotation (P = .001). Forty percent returned to their preoperative sports level. Higher grades of arthrosis were seen in the SS (20% absent, 40% mild, 25% moderate, and 15% severe) versus CS (P = .002). At long-term follow-up, 65% of patients treated with an arthroscopic Bankart repair using bioabsorbable tacks had a well-functioning, stable shoulder. Disability scores were greatest with sports; however, the majority of patients had well-preserved ranges of motion and good functional

  3. Climatological Analysis of the Exclusive Economic Zone of Mexico Based on 10 Years of Satellite Imagery

    NASA Astrophysics Data System (ADS)

    Gonzalez Rodriguez, E.; Trasviña-Castro, A.; Aguirre Bahena, F.

    2013-05-01

    low (<25 mg m-3) and are not found associated to low temperatures and/or low depths of the euphotic zone. The oceanic region shows maximum values for both sea surface temperatures and depth of the euphotic zone as is to be expected in oligotrophic regions of the sea. Anomalies for all three variables will also shown to discuss the interannual variability of this 10-years period of study.

  4. The Remains of the Dam: What Have We Learned From 10 Years of Dam Removals?

    NASA Astrophysics Data System (ADS)

    Grant, G. E.; O'Connor, J. E.; Major, J. J.

    2012-12-01

    Over the past 10 years in the U.S., dam removal has evolved from an occasionally implemented, rarely studied, and poorly understood intervention to improve rivers, to a much more frequently accomplished and better studied and understood approach to river restoration. Over that same time period, the numbers and sizes of dams and volumes of sediment released have dramatically increased. By some estimates close to 1000 dams have been removed over the last 100 years, with most of those occurring within the last 10. While most of these are small (less than 15 m high) dams, removals of dams up to 70 m high are presently underway. Releases of sediment associated with these removals over the past 10 years have also increased by close to four orders of magnitude; for example removal of the Elwha River dams in Washington is estimated to release almost 107 m3 of sediment into the lower Elwha River. Given a decade's worth of dam removals and, in some cases, well-orchestrated case studies of the effects of removal on the geomorphology and (to a lesser extent) ecology of rivers, what have we learned? More specifically, where do we now stand with respect to being able to predict the consequences of future dam removals? Drawing on both field examples and numerical models of dam removals in the western U.S., several key lessons stand out. Although every dam removal and river are different, removals initiate very rapid upstream river response and reservoir erosion and evacuation of sediment by various mechanisms that are strongly controlled by grain size of the deposit, volumes of residual sediment relative to total reservoir volume, and style of dam removal (instantaneous versus staged). Erosion of sediment accumulations in fully and partially filled (by sediment) reservoirs proceeds by different trajectories and rates, with full reservoirs releasing sediment primarily by upstream knickpoint retreat while erosion and sediment release in partially-filled reservoirs proceeds by

  5. PLANT POISONING IN THAILAND: A 10-YEAR ANALYSIS FROM RAMATHIBODI POISON CENTER.

    PubMed

    Sriapha, Charuwan; Tongpoo, Achara; Wongvisavakorn, Sunun; Rittilert, Panee; Trakulsrichai, Satariya; Srisuma, Sahaphume; Wananukul, Winai

    2015-11-01

    Plant poisoning is not uncommon in Thailand. The objective of this study was to determine the incidence, type, clinical manifestations, severity and outcomes of plant poisoned patients in Thailand over a 10-year period. We retrospectively reviewed data from the Ramathibodi Poison Center Toxic Exposure Surveillance System for 2001-2010. A total of 2,901 poisonous plant exposure cases were identified, comprising 3.1% of the 92,392 poison cases recorded during the study period. This was the fifth most common type of poisoning recorded. Children aged < 13 years comprised the largest percent (69.8%) of the cases. The major type of exposure was unintentional ingestion. Ninety-nine types of poisonous plants were recorded as the causative agents among 99.1%of the cases. Gastrointestinal symptoms were reported in 72.0% of cases with Jatropha curcas (physic nut) comprising 54.1% of these. Most patients had only minor signs and symptoms. The mortality rate among the total plant poisoning cases was 0.9%, with 26 deaths. Thirteen deaths occurred in children aged < 13 years. The greatest number of fatalities were due to ingestion of Manihot esculenta (cassava), primarily due to multi-system organ failure. Children aged < 13 years are at the greatest risk for plant poisoning in Thailand; mostly unintentional. Most cases were minor and the mortality rate was low. Jatropha curcas was the most common cause of poisoning and Manihot esculenta was the most common cause of death. Public education is important to minimize these poisonings.

  6. Hydrocephalus research funding from the National Institutes of Health: a 10-year perspective.

    PubMed

    Gross, Paul; Reed, Gavin T; Engelmann, Rachel; Kestle, John R W

    2014-02-01

    Funding of hydrocephalus research is important to the advancement of the field. The goal of this paper is to describe the funding of hydrocephalus research from the National Institutes of Health (NIH) over a recent 10-year period. The NIH online database RePORT (Research Portfolio Online Reporting Tools) was searched using the key word "hydrocephalus." Studies were sorted by relevance to hydrocephalus. The authors analyzed funding by institute, grant type, and scientific approach over time. Over $54 million was awarded to 59 grantees for 66 unique hydrocephalus proposals from 48 institutions from 2002 to 2011. The largest sources of funding were the National Institute of Neurological Disease and Stroke and the National Institute of Child Health and Human Development. Of the total, $22 million went to clinical trials, $15 million to basic science, and $10 million to joint ventures with small business (Small Business Innovation Research or Small Business Technology Transfer). Annual funding varied from $2.3 to $8.1 million and steadily increased in the second half of the observation period. The number of new grants also went from 15 in the first 5 years to 27 in the second 5 years. A large portion of the funding has been for clinical trials. Funding for shunt-device development grew substantially. Support for training of hydrocephalus investigators has been low. Hydrocephalus research funding is low compared with that for other conditions of similar health care burden. In addition to NIH applications, researchers should pursue other funding sources. Small business collaborations appear to present an opportunity for appropriate projects.

  7. Percutaneous radiofrequency ablation of renal tumors in high-risk patients: 10 years' experience.

    PubMed

    Alguersuari, A; Mateos, A; Falcó, J; Criado, E; Fortuño, J R; Guitart, J

    2016-01-01

    To retrospectively evaluate the efficacy and safety of percutaneous radiofrequency ablation (RFA) done to treat renal tumors in patients with high surgical risk or with the risk of developing multiple renal tumors in the medium term at our center over a period of 10 years. Between 2005 and 2015, we used RFA to treat 89 T1a or T1b tumors in 87 patients (mean age, 73.7±10.87 years) with high surgical risk. We excluded patients treated with radiofrequency and embolization or microwave ablation. The tumors treated were clear cell carcinomas (43.6%), papillary renal carcinomas (17.2%), chromophobe renal cell carcinomas (10.3%), cystic tumors (2.2%), and an angiomyolipoma (1.1%). The mean size of the tumors was 2.6cm. Computed tomography and/or ultrasonography were used to guide the procedure. We analyzed the relation between the efficacy of the procedure and patients' age, the type of needle, the source of the patients, the size and location of the tumor, and the number of sessions required to achieve ablation. We recorded all complications. The RFA procedure was completed in all patients. The mean follow-up period was 32.1 months. The efficacy was 93.7%. A single session was sufficient in 87.5% of patients; 8% required two sessions and 4.5% required three sessions. The only factor associated with worse efficacy was the size of the tumor (p=0.03). The rate of complications was 5.6%. RFA is efficacious and safe, with results comparable to those reported in the literature. Copyright © 2016 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Validation of 10 years of SAO OMI Ozone Profiles with Ozonesonde and MLS Observations

    NASA Astrophysics Data System (ADS)

    Huang, G.; Liu, X.; Chance, K.; Bhartia, P. K.

    2015-12-01

    To evaluate the accuracy and long-term stability of the SAO OMI ozone profile product, we validate ~10 years of ozone profile product (Oct. 2004-Dec. 2014) against collocated ozonesonde and MLS data. Ozone profiles as well stratospheric, tropospheric, lower tropospheric ozone columns are compared with ozonesonde data for different latitude bands, and time periods (e.g., 2004-2008/2009-2014 for without/with row anomaly. The mean biases and their standard deviations are also assessed as a function of time to evaluate the long-term stability and bias trends. In the mid-latitude and tropical regions, OMI generally shows good agreement with ozonesonde observations. The mean ozone profile biases are generally within 6% with up to 30% standard deviations. The biases of stratospheric ozone columns (SOC) and tropospheric ozone columns (TOC) are -0.3%-2.2% and -0.2%-3%, while standard deviations are 3.9%-5.8% and 14.4%-16.0%, respectively. However, the retrievals during 2009-2014 show larger standard deviations and larger temporal variations; the standard deviations increase by ~5% in the troposphere and ~2% in the stratosphere. Retrieval biases at individual levels in the stratosphere and upper troposphere show statistically significant trends and different trends for 2004-2008 and 2009-2014 periods. The trends in integrated ozone partial columns are less significant due to cancellation from various layers, except for significant trend in tropical SOC. These results suggest the need to perform time dependent radiometric calibration to maintain the long-term stability of this product. Similarly, we are comparing the OMI stratospheric ozone profiles and SOC with collocated MLS data, and the results will be reported.

  9. Outcomes of combined phacoemulsification and deep sclerectomy: a 10-year UK single-centre study

    PubMed Central

    Mercieca, K; Shevade, B; Anand, N

    2015-01-01

    Purpose To report the outcomes of combined phacoemulsification and -deep sclerectomy (phaco-DS) from a single UK centre over a 10-year period. Methods Retrospective analysis of phaco-DS data extracted from an ongoing glaucoma surgery database within Calderdale and Huddersfield NHS Trust. Two hundred and ninety-six eyes of 282 patients were included. Data included patient demographics, pre- and postoperative intraocular pressure (IOP), use of mitomycin C (MMC), spacer device implantation, and follow-up details including surgical success rates. IOP success criteria were: (A) IOP <19 mm Hg and/or 20% decrease from baseline and (B) IOP <16 mm Hg and/or 30% drop from baseline. Results Mean follow-up was 63.5±35.3 months. MMC was applied in 145 eyes (49%). Kaplan–Meier success rates in all eyes for criteria A were 89.1% and 80% with glaucoma medications (qualified success) and 81.2% and 68.3% without medications (unqualified success) at 2 and 5 years, respectively. Qualified success for criteria B was 72.4 and 61.4% and unqualified rates were 67.2 and 55.2% for the same time periods. Repeated-measures ANOVA showed significantly lower IOP in the phaco-DS with MMC group up to 3 years postoperatively (P=0.002). Cox's proportional hazards for criteria B, however, showed no significant effect of MMC application in the long term (P=0.2). Increasing age and laser goniopuncture were positively associated with success, whereas the absence of spacer devices was negatively associated. At last follow-up, 20% of eyes were on glaucoma medications. Complication rates were low with hypotony rates of 0.68%. Conclusions This study confirms the long-term safety and efficacy of phaco-DS as a primary glaucoma procedure. PMID:26337945

  10. Clinical drug trials in general practice: a 10-year overview of protocols.

    PubMed

    Brænd, Anja Maria; Jensen, Kaspar Buus; Klovning, Atle; Straand, Jørund

    2013-06-01

    Drugs predominantly prescribed in general practice should ideally be tested in that setting; however, little is known about drug trials in general practice. Our aim was to describe drug trials in Norwegian general practice over the period of a decade. The present work concerns a 10-year retrospective study of protocols submitted to the Norwegian national medicines agency (1998 to 2007) identifying all studies involving general practitioners (GPs) as clinical investigator(s). We analyzed the number of trials, drug company involvement, patients, participating doctors, payment, medications tested and main diagnostic criteria for inclusion. We also analyzed one trial in greater detail. Out of 2,054 clinical drug trials, 196 (9.5%) were undertaken in general practice; 93% were multinational, 96% were industry funded and 77% included patients both from general practice and specialist care. The trials were planned to be completed in the period 1998 to 2012. A total of 23,000 patients in Norway and 340,000 patients internationally were planned to be included in the 196 trials. A median of 5 GPs participated in each trial (range 1 to 402). Only 0.7% of 831 GP investigators had general practice university affiliations. Median payment for participating investigators was €1,900 (range €0 to 13,500) per patient completing the trial. A total of 30 pharmaceutical companies were involved. The drugs most commonly studied were antidiabetics (21%), obstructive airway disease medications (12%), agents acting on the renin-angiotensin system (10%), and lipid modifying agents (10%). One trial, presented in more detail, had several characteristics of a seeding or marketing trial. Only one in four drug trials involving general practice were solely general practice trials and almost all were industry initiated without input from academic general practice. There was a large variation in the number of patients, participating doctors, and economic compensation for trial investigators, with

  11. Clinical drug trials in general practice: a 10-year overview of protocols

    PubMed Central

    2013-01-01

    Background Drugs predominantly prescribed in general practice should ideally be tested in that setting; however, little is known about drug trials in general practice. Our aim was to describe drug trials in Norwegian general practice over the period of a decade. Methods The present work concerns a 10-year retrospective study of protocols submitted to the Norwegian national medicines agency (1998 to 2007) identifying all studies involving general practitioners (GPs) as clinical investigator(s). We analyzed the number of trials, drug company involvement, patients, participating doctors, payment, medications tested and main diagnostic criteria for inclusion. We also analyzed one trial in greater detail. Results Out of 2,054 clinical drug trials, 196 (9.5%) were undertaken in general practice; 93% were multinational, 96% were industry funded and 77% included patients both from general practice and specialist care. The trials were planned to be completed in the period 1998 to 2012. A total of 23,000 patients in Norway and 340,000 patients internationally were planned to be included in the 196 trials. A median of 5 GPs participated in each trial (range 1 to 402). Only 0.7% of 831 GP investigators had general practice university affiliations. Median payment for participating investigators was €1,900 (range €0 to 13,500) per patient completing the trial. A total of 30 pharmaceutical companies were involved. The drugs most commonly studied were antidiabetics (21%), obstructive airway disease medications (12%), agents acting on the renin-angiotensin system (10%), and lipid modifying agents (10%). One trial, presented in more detail, had several characteristics of a seeding or marketing trial. Conclusions Only one in four drug trials involving general practice were solely general practice trials and almost all were industry initiated without input from academic general practice. There was a large variation in the number of patients, participating doctors, and economic

  12. ESA SMART-1 mission: review of results and legacy 10 years after launch

    NASA Astrophysics Data System (ADS)

    Foing, Bernard

    2014-05-01

    We review ESA's SMART-1 highlights and legacy 10 years after launch. The SMART-1 mission to the Moon achieved record firsts such as: 1) first Small Mission for Advanced Research and Technology; with spacecraft built and integrated in 2.5 years and launched 3.5 years after mission approval; 2) first mission leaving the Earth orbit using solar power alone with demonstration for future deep space missions such as BepiColombo; 3) most fuel effective mission (60 litres of Xenon) and longest travel (13 month) to the Moon!; 4) first ESA mission reaching the Moon and first European views of lunar poles; 5) first European demonstration of a wide range of new technologies: Li-Ion modular battery, deep-space communications in X- and Ka-bands, and autonomous positioning for navigation; 6) first lunar demonstration of an infrared spectrometer and of a Swept Charge Detector Lunar X-ray fluorescence spectrometer ; 7) first ESA mission with opportunity for lunar science, elemental geochemistry, surface mineralogy mapping, surface geology and precursor studies for exploration; 8) first controlled impact landing on the Moon with real time observations campaign; 9) first mission supporting goals of the ILEWG/COSPAR International Lunar Exploration Working Group in technical and scientific exchange, international collaboration, public and youth engagement; 10) first mission preparing the ground for ESA collaboration in Chandrayaan-1, Chang'E1-2-3 and near-future landers, sample return and human lunar missions. The SMART-1 technology legacy is applicable to geostationary satellites and deep space missions using solar electric propulsion. The SMART-1 archive observations have been used to support scientific research and prepare subsequent lunar missions and exploration. Most recent SMART-1 results are relevant to topics on: 1) the study of properties of the lunar dust, 2) impact craters and ejecta, 3) the study of illumination, 4) observations and science from the Moon, 5) support to

  13. Actual over 10-year survival after liver resection for patients with intrahepatic cholangiocarcinoma.

    PubMed

    Si, Anfeng; Li, Jun; Xiang, Hongjun; Zhang, Shichao; Bai, Shilei; Yang, Pinghua; Zhang, Xiaofeng; Xia, Yong; Wang, Kui; Yan, Zhenlin; Lau, Wan Yee; Shi, Lehua; Shen, Feng

    2017-07-04

    Partial hepatectomy is a potentially curative therapy for intrahepatic cholangiocarcinoma (ICC). Unfortunately, the overall surgical prognosis remains dismal and the actual 10-year survival has not been reported. This study aimed to document 10-year actual survival rates, identify the prognostic factors associated with 10-year survival rate, and analyze the characteristics of patients who survived ≥ 10 years. Among 251 patients who underwent curative liver resection for ICC between 2003 and 2006 at the Eastern Hepatobiliary Surgery Hospital, 21 patients (8.4%) survived ≥ 10 years. The 5-, 7-, and 10-year overall survival rates were 32.3%, 22.3% and 8.4%, respectively. The 10-year cumulative incidence of ICC-related death and recurrence were 80.9% and 85.7%, respectively. Multivariate analysis based on competing risk survival analysis identified that tumor > 5 cm was independently associated with ICC-related death and recurrence (hazard ratios: 1.369 and 1.445, respectively), in addition to carcinoembryonic antigen (CEA) >10 U/mL, carbohydrate antigen 19-9 (CA19-9) >39 U/mL, multiple nodules, vascular invasion, nodal metastasis and local extrahepatic invasion. Patients who survived ≥ 10 years had a longer time to first recurrence, lower levels of CEA, CA19-9 and alkaline phosphatase, less perioperative blood loss, solitary tumor, smaller tumor size, and absence of nodal metastasis or local extrahepatic invasion. In conclusion, a 10-year survival after liver resection for ICC is possible and can be expected in approximately 8.4% of patients.

  14. [Clinicopathologic features of hepatocellular carcinoma patients surviving more than 10 years after radical hepatectomy].

    PubMed

    Wu, L Q; Wang, Z S; Cao, J Y; Hu, W Y; Han, B; Sun, C D; Zhang, B Y; Qiu, F B; Zhang, S; Yang, J Y; Cui, Z J

    2017-02-01

    Objective: To clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients survived more than 10 years after radical hepatectomy. Methods: Two hundreds and fifty-two patients who underwent curative resection for HCC between January 1999 and March 2006 at Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qingdao University were included.There were 217 male cases and 35 female cases aging from 17 to 82 years with median age of (53.8±10.5)years. Followed by March 31 2016, clinicopathologic factors in 10-year survivors and patients who died within 10 years were compared by χ(2) test, Kaplan-Meier survival analysis and Cox proportional hazards model and the prognostic factors affecting survival were identified. Results: All patients were followed-up for 4.0 to 205.7 months with median time of 53.4 months. The 10-year overall survival rate was 26%, there were 62 cases(26.2%) who survived for more than 10 years after initial hepatectomy. In survival >10-year group, the paitents with ALT<40 U/L, gamma-glutamyl transpeptidase<64 U/L, albumin≥35 g/L, without liver cirrhosis and portal hypertension, Child-Pugh grade A, no blood transfusion, AFP≤20 μg/L, tumor size ≤5.0 cm, single tumor, high differentiation, TNM stage Ⅰ and TACE negative after resection were more than the patients in survival <10-year group (P<0.05). In multivariate analysis, Child-Pugh grade A, the tumor size ≤5.0 cm and TACE negative after resection were favorable independent factors associated with 10-year survival (P<0.05). Conclusion: Based on the results of the study, Child-Pugh grade A, tumor size ≤5.0 cm and TACE negative after resection at initial hepatectomy might be biologically favorable conditions for patients surviving more than 10 years.

  15. Mandibular implant overdentures followed for over 10 years: patient compliance and prosthetic maintenance.

    PubMed

    Rentsch-Kollar, Andrea; Huber, Sandra; Mericske-Stern, Regina

    2010-01-01

    The mandibular implant overdenture is a popular treatment modality and is well documented in the literature. Follow-up studies with a long observation period are difficult to perform due to the increasing age of patients. The present data summarize a long-term clinical observation of patients with implant overdentures. Between 1984 and 1997, edentulous patients were consecutively admitted for treatment with an implant overdenture. The dentures were connected to the implants by means of bars or ball anchors. Regular maintenance was provided with at least one or two scheduled visits per year. Recall attendance and reasons for dropout were analyzed based on the specific history of the patient. Denture maintenance service, relining, repair, and fabrication of new dentures were identified, and complications with the retention devices specified separately. In the time period from 1984 to 2008, 147 patients with a total of 314 implants had completed a follow-up period of >10 years. One hundred one patients were still available in 2008, while 46 patients were not reexamined for various reasons. Compliance was high, with a regular recall attendance of >90%. More than 80% of dentures remained in continuous service. Although major prosthetic maintenance was rather low in relation to the long observation period, visits to a dental hygienist and dentist resulted in an annual visit rate of 1.5 and 2.4, respectively. If new dentures became necessary, these were made in student courses, which increased the treatment time and number of appointments needed. Complications with the retention devices consisted mostly of the mounting of new female retainers, the repair of bars, and the changing of ball anchors. The average number of events and the rate of prosthetic service with ball anchors were significantly higher than those with bars. Twenty-two patients changed from ball anchors to bars; 9 patients switched from a clip bar to a rigid U-shaped bar. This long-term follow-up study

  16. 27 CFR 25.164 - Quarterly and semimonthly returns.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax Returns... on beer (unless prepaid) by return on Form 5000.24. The brewer shall file Form 5000.24 as a return... file a return on Form 5000.24 for each return period even though no beer was removed for consumption...

  17. 27 CFR 25.164 - Quarterly and semimonthly returns.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Preparation and Remittance of Tax Returns... on beer (unless prepaid) by return on Form 5000.24. The brewer shall file Form 5000.24 as a return... file a return on Form 5000.24 for each return period even though no beer was removed for consumption or...

  18. 27 CFR 25.164 - Quarterly and semimonthly returns.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax Returns... on beer (unless prepaid) by return on Form 5000.24. The brewer shall file Form 5000.24 as a return... file a return on Form 5000.24 for each return period even though no beer was removed for consumption...

  19. 27 CFR 25.164 - Quarterly and semimonthly returns.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL BEER Tax on Beer Preparation and Remittance of Tax Returns... on beer (unless prepaid) by return on Form 5000.24. The brewer shall file Form 5000.24 as a return... file a return on Form 5000.24 for each return period even though no beer was removed for consumption...

  20. Some risk factors for periodontal bone loss in 50-year-old individuals. A 10-year cohort study.

    PubMed

    Paulander, Jörgen; Wennström, Jan L; Axelsson, Per; Lindhe, Jan

    2004-07-01

    The aim of this 10-year prospective study of 50-year-old individuals was to analyze the incidence of periodontal bone loss and potential risk factors for periodontal bone loss. The subject sample was generated from an epidemiological survey performed in 1988 of subjects living in the County of Värmland, Sweden. A randomized sample of 15% of the 50-year-old inhabitants in the county was drawn. At the 10-year follow-up in 1998, 320 (75%) of the 449 individuals examined at baseline were available for re-examination, out of which 4 had become edentulous. Full-mouth clinical and radiographic examinations and questionnaire surveys were performed in 1988 and 1998. Two hundred and ninety-five individuals (69%) had complete data for inclusion in the analysis of radiographic bone changes over 10 years. Non-parametric tests, correlations and stepwise multiple regression models were used for statistical analysis of the data. The mean alveolar bone level (ABL) in 1988 was 2.2 mm (0.05) and a further 0.4 mm (0.57) (p=0.000) was lost over the 10 years. Eight percent of the subject sample showed no loss, while 5% experienced a mean bone loss of >/=1 mm. Smoking was found to be the strongest individual risk predictor (RR=3.2; 95% CI 2.03-5.15). When including as smokers only those individuals who had continued with the habit during the entire 10-year follow-up period, the relative risk was slightly increased (3.6; 95% CI 2.32-5.57). Subjects who had quit smoking before the baseline examination did not demonstrate a significantly increased risk for disease progression (RR=1.3; 95% CI 0.57-2.96). Stepwise multiple regression analysis revealed that smoking, % approximal sites with probing pocket depth >/=4 mm, number of teeth and systemic disease were significant explanatory factors for 10-year ABL loss (R(2)=0.12). For never smokers, statistically significant predictors were number of teeth, mean ABL, % periodontally healthy approximal sites and educational level (R(2)=0.20). The

  1. Treating severe partial anodontia: a 10-year history of patient treatment.

    PubMed

    Dario, L J; Aschaffenburg, P H

    1994-12-01

    Severe partial anodontia is relatively rare. This case report describes the 10-year treatment history of a patient with partial anodontia, beginning with removable partial overlay dentures and culminating with fixed implant prostheses.

  2. A 10-year longitudinal study of tubal function in patients with nasopharyngeal carcinoma after irradiation.

    PubMed

    Young, Y H; Cheng, P W; Ko, J Y

    1997-09-01

    To follow up the chronological change of tubal function in patients with nasopharyngeal carcinoma for 10 years after irradiation. Patients with nasopharyngeal carcinoma were subjected to eustachian tube function tests before irradiation and 6 months, 5 years, and 10 years after irradiation. University hospital. Ten patients (20 ears), 7 men and 3 women. Twelve (60%) of the ears had patulous tubes 10 years after irradiation, which might result from atrophy of peritubal tissues. The occurrence of a patulous tube was independent of the radiation dosage, but it was related to the interval since irradiation. Development of a patulous tube is associated with correction of organic obstruction of the eustachian tube. Resolution of the inflammatory reaction plays the most important role in recovery of function of the tube. Therefore, the prevalence of middle ear complications is low 10 years after irradiation.

  3. Genetic Contributions to Age-Related Decline in Executive Function: A 10-Year Longitudinal Study of COMT and BDNF Polymorphisms

    PubMed Central

    Erickson, Kirk I.; Kim, Jennifer S.; Suever, Barbara L.; Voss, Michelle W.; Francis, B. Magnus; Kramer, Arthur F.

    2008-01-01

    Genetic variability in the dopaminergic and neurotrophic systems could contribute to age-related impairments in executive control and memory function. In this study we examined whether genetic polymorphisms for catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) were related to the trajectory of cognitive decline occurring over a 10-year period in older adults. A single nucleotide polymorphism in the COMT (Val158/108Met) gene affects the concentration of dopamine in the prefrontal cortex. In addition, a Val/Met substitution in the pro-domain for BDNF (Val66Met) affects the regulated secretion and trafficking of BDNF with Met carriers showing reduced secretion and poorer cognitive function. We found that impairments over the 10-year span on a task-switching paradigm did not vary as a function of the COMT polymorphism. However, for the BDNF polymorphism the Met carriers performed worse than Val homozygotes at the first testing session but only the Val homozygotes demonstrated a significant reduction in performance over the 10-year span. Our results argue that the COMT polymorphism does not affect the trajectory of age-related executive control decline, whereas the Val/Val polymorphism for BDNF may promote faster rates of cognitive decay in old age. These results are discussed in relation to the role of BDNF in senescence and the transforming impact of the Met allele on cognitive function in old age. PMID:18958211

  4. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis.

    PubMed

    Reginster, J-Y; Kaufman, J-M; Goemaere, S; Devogelaer, J P; Benhamou, C L; Felsenberg, D; Diaz-Curiel, M; Brandi, M-L; Badurski, J; Wark, J; Balogh, A; Bruyère, O; Roux, C

    2012-03-01

    In an open-label extension study, BMD increased continuously with strontium ranelate over 10 years in osteoporotic women (P < 0.01). Vertebral and nonvertebral fracture incidence was lower between 5 and 10 years than in a matched placebo group over 5 years (P < 0.05). Strontium ranelate's antifracture efficacy appears to be maintained long term. Strontium ranelate has proven efficacy against vertebral and nonvertebral fractures, including hip, over 5 years in postmenopausal osteoporosis. We explored long-term efficacy and safety of strontium ranelate over 10 years. Postmenopausal osteoporotic women participating in the double-blind, placebo-controlled phase 3 studies SOTI and TROPOS to 5 years were invited to enter a 5-year open-label extension, during which they received strontium ranelate 2 g/day (n = 237, 10-year population). Bone mineral density (BMD) and fracture incidence were recorded, and FRAX® scores were calculated. The effect of strontium ranelate on fracture incidence was evaluated by comparison with a FRAX®-matched placebo group identified in the TROPOS placebo arm. The patients in the 10-year population had baseline characteristics comparable to those of the total SOTI/TROPOS population. Over 10 years, lumbar BMD increased continuously and significantly (P < 0.01 versus previous year) with 34.5 ± 20.2% relative change from baseline to 10 years. The incidence of vertebral and nonvertebral fracture with strontium ranelate in the 10-year population in years 6 to 10 was comparable to the incidence between years 0 and 5, but was significantly lower than the incidence observed in the FRAX®-matched placebo group over 5 years (P < 0.05); relative risk reductions for vertebral and nonvertebral fractures were 35% and 38%, respectively. Strontium ranelate was safe and well tolerated over 10 years. Long-term treatment with strontium ranelate is associated with sustained increases in BMD over 10 years, with a good safety profile. Our results also support

  5. Long-term Outcomes After Ulnar Collateral Ligament Reconstruction in Competitive Baseball Players: Minimum 10-Year Follow-up.

    PubMed

    Osbahr, Daryl C; Cain, E Lyle; Raines, B Todd; Fortenbaugh, Dave; Dugas, Jeffrey R; Andrews, James R

    2014-06-01

    Ulnar collateral ligament reconstruction (UCLR) has afforded baseball players with excellent results; however, previous studies have described only short-term outcomes. To evaluate long-term outcomes after UCLR in baseball players. Case series; Le