Figure 1 : Backpointers Based on Initial Propagation from Goal State 10 Figure 2 : Robot Discovers First Unknown Obstacle Cell I 1 Figure 3 : Robot...Moves Up in Search of Path around Obstacle 11 Figure 4 : Robot Moves Down in Search of Path around Obstacle 12 Figure 5 : RAISE States Propagate out of...Dynamic Obstacle 25 Figure 14 : Discovering that the Obstacle has Moved 25 Figure 15 : Path Planning with Potential Fields 26 Figure 16 : Path Planning
Process 10 Figure 2-2: BPMN Example 11 Figure 2-3: Business Measures Summary 12 Figure 2-4: BPEL Mapping 13 Figure 2-5: Proposed Optimization Loop...a BPMS. Graphical standards in this stage (e.g., business process modeling and notation [ BPMN ], Unified Modeling Language activity diagrams) allow...structured as follows. Section 2.2 introduces the key technologies used in our study, BPMN and business process execution language (BPEL); Section 2.3
Kohorn, E. I.
The persons who directed the academic teaching of women's health at Yale Medical School are presented by biographical sketches recounting their achievements and some of the difficulties they encountered. Three who provided particular catalysis were Nathan Smith, Herbert Thoms, and Lee Buxton. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 PMID:8303913
62 APPENDIX C. SAMPLE NUMERICAL RUN ........................65 APPENDIX D. SAMPLE EXPERIMENTAL RUN .........................67...10 Figure 4. Finite element model ..............................11 Figure 5. Sample Model meshing (X/D=2,S/D=2,L/D=1.2) ........13 Figure 6...the last 10 iterations. 12 Figure 5. Sample Model meshing (X/D=2,S/D=2,L/D=1.2) 5. Solution Technique All
Nykoliation, J. W.; Cassidy, J. D.; Dupuis, P.; Yong-Hing, K.; Crnec, M.
Three cases of patients with fracture-dislocations of their cervical spines following forced flexion injuries are presented. All received cervical manipulation without proper clinical and radiographic evaluation. These cases stress the importance of a thorough examination prior to the application of manipulative therapy. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 12Figure 13
Weaponeer Performance - 250m High Contrast Target ................... 7 Figure 5. B-LPS and Weaponeer Performance - All Targets ( Group 1...9 Figure 6. B-LPS and Weaponeer Performance - 100m Target ( Group 1) ........................ 10 Figure 7. B-LPS and Weaponeer Performance...250m Low Contrast Target ( Group 1) .......... 11 Figure 8. B-LPS and Weaponeer Performance - 250m High Contrast Target ( Group 1) ........ 12 Figure 9. B
Epstein, Joel B.; Mathias, Richard G.
The AIDS epidemic continues. All health-care workers, including physicians and dental personnel, may be instrumental in recognizing risk factors associated with Acquired Immunodeficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) infection. Oral signs and symptoms of HIV infection may be the first presentation of the disease or may develop during the course of the disease and require management. Knowledge of the signs, symptoms and associated infections and tumours is needed to assist in recognition, diagnosis, and treatment. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 12Figure 13 PMID:21253078
Cox, Francis J.; Meier, August W.
Of 105 cases of Colles' fracture, 86 were treated by closed reduction and plaster immobilization alone; 19 cases in which the fractures were more severe were treated by fixed skeletal traction using an external skeletal traction splint. Despite the greater severity of the lesions, the end results, both anatomic and functional, were generally better in those cases in which skeletal traction was used than in those treated by closed reduction. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12.Figure 13. PMID:14801716
Brody, J P; Yager, P; Goldstein, R E; Austin, R H
The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing. Images FIGURE 1 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 PMID:8968612
2.1.4 Wiring diagrams ........................................................................................................ 10 2.2 Field work...10 Figure 11. SCADA system wiring diagram...11 Figure 12. Wiring diagram for cellular system. ........................................................................ 12
Cottier, H.; Turk, J.; Sobin, L.
This Memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports, that use such terms as “hyperplasia” or “nonspecific lymphadenitis”. ImagesFigure 22Figure 13Figure 5Figure 4Figure 3Figure 14Figure 15Figure 9Figure 21Figure 8Figure 12Figure 17Figure 16Figure 2Figure 7Figure 6Figure 20Figure 19Figure 11Figure 10Figure 18 PMID:4539822
Kapoor, V. K.
Tuberculosis has staged a global comeback and forms a dangerous combination with AIDS. The abdomen is one of the common sites of extrapulmonary involvement. Patients with abdominal tuberculosis have a wide range and spectrum of symptoms and signs; the disease is therefore a great mimic. Diagnosis, mainly radiological and supported by endoscopy, is difficult to make and laparotomy is required in a large number of patient. Management involves judicious combination of antitubercular therapy and surgery which may be required to treat complications such as intestinal obstruction and perforation. The disease, though potentially curable, carries a significant morbidity and mortality. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:9926119
Mikkelsen, William P.; Pattison, Arthur C.
Splenoportagraphy has become an almost indispensable adjunct to the surgical management of portal hypertension. In many instances it will provide the basis for the selection of the operative procedure. Certain instances of intrahepatic portal hypertension due to cirrhosis that might better be managed by splenorenal shunt rather than by the generally preferred method of direct end-to-side portacaval shunt may be determined by this procedure. The procedure finds its greatest application in the accurate delineation of the three major types of extrahepatic portal hypertension, each of which demands a different surgical approach. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12.Figure 13.Figure 14. PMID:13413692
McMillan, E. M.; Stoneking, L.; Humphrey, G. B.; Rapacz, J.
A monoclonal immunocytochemical method with 25 monoclonal antibodies was used to study the distribution in human tonsil of determinants expressed on T cells (mature and immature), Langerhans cells, B cells, killer/natural killer cells, macrophages, immature myeloid and lymphoblastic leukemia cells. Many of the respective determinants were found to have a discrete topographic distribution in normal reactive tonsil. The common acute lymphoblastic leukemia antigen and a determinant found on myeloblastic leukemia cells (My10) were not found in the specimens of the tonsil examined. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:2435159
Shepstone, B. J.
This paper reviews the development of cerebral scintigraphy from its early days of planar imaging with simple technetium-99m labelled compounds to the recent revival of the technique in the form of positron-emission and single-photon emission tomography. A short explanation of instrumentation and radiopharmaceuticals is given as a prelude to a description of both techniques in normal and pathological situations. Particular emphasis is placed on the more readily-available single-photon emission-tomographic techniques using labelled amines in the functional investigation of disorders not readily diagnosed by computed tomography. Images Figure 2(a) Figure 3 Figure 4 Figure 5 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:3047720
Berry, J. P.; Henoc, P.; Galle, P.
The progressive transformation of illite crystals in alveolar macrophages has been studied with x-ray microanalysis and electron microdiffraction. Illite particles captured by macrophages undergo a series of progressive modifications which affect their ultrastructure, crystalline state, and chemical composition. Crystalline structure progressively disappears and certain elements are eliminated. At the end of the experiment, which lasted more than 6 months, the initial characteristics of the particles were greatly transformed. The constitutive elements of the illite particles were also found in structures other than macrophages: Type I pneumocytes, interstitium, and blood platelets. Images Figure 1 Figure 2 Figure 7 Figure 8 Figure 3 Figure 9 Figure 10 Figure 4 Figure 11 Figure 12 Figure 5 Figure 6 PMID:211849
Roncero, V; Vincente, J A; Redondo, E; Gãzquez, A; Duran, E
A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial hyperplasia and necrosis, both in cells forming part of the filtration barrier and in those in the interlamellar space. These processes developed in the course of the experiment, leading to the death of tench after 12 to 15 days of exposure to 75 ppm lead nitrate, at which point the concentrations of lead in the gills had reached their maximum. Images FIGURE 1. FIGURE 2. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 13. FIGURE 14. FIGURE 15. FIGURE 16. FIGURE 17. FIGURE 18. FIGURE 19. PMID:2088740
Chiu, W; Schmid, M F; Prasad, B V
Electron microscopic analysis can be used to determine the three-dimensional structures of macromolecules at resolutions ranging between 3 and 30 A. It differs from nuclear magnetic resonance spectroscopy or x-ray crystallography in that it allows an object's Coulomb potential functions to be determined directly from images and can be used to study relatively complex macromolecular assemblies in a crystalline or noncrystalline state. Electron imaging already has provided valuable structural information about various biological systems, including membrane proteins, protein-nucleic acid complexes, contractile and motile protein assemblies, viruses, and transport complexes for ions or macromolecules. This article, organized as a series of lectures, presents the biophysical principles of three-dimensional analysis of objects possessing different symmetries. Images FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 17 FIGURE 18 PMID:8324196
Millard, D. R.
Primary correction of congenital clefts of the lip and palate should be designed to carry the interrupted embryonic process to normal completion. This is best accomplished by maxillary alignment with presurgical orthodontics, stabilisation of the maxillary alignment, obliteration of the alveolar cleft and construction of the nasal floor with periosteoplasty. This allows early construction of the lip by rotation and advancement and correction of the nose with columella lengthening, alar cartilage positioning and alar base cinching. This can be accomplished before school age. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 PMID:8017808
Gbps Data Atream 11 6.1 LVDS Input...results of the clock generation circuits......................................................11 Figure 12. Schematic of the LVDS input stage...12 Figure 13. Bias points of the LVDS input stage
11 Figure 4: Migrant Risk Perception Curve ............................................................................ 12 Figure 5...37 Figure 24: Transparency International’s Corruption Perception Index vs Refugee Outflow Numbers...GDP ....................................................................... 43 Figure 29: Refugees Influx vs Corruption Perception Index
Posch, Thomas; et al.
During the final stages of their evolution, stars with low to intermediate masses produce huge quantities - up to the order of earth masses per year - of dust grains. This production of solid particles is of crucial importance both for the physico-chemical conditions in the respective circumstellar environments and for the cosmic cycle of matter. The branch of astronomy dealing with cosmic dust - sometimes referred to as solid state astrophysics - uses three principal methods: astronomical infrared spectroscopy, laboratory measurements of optical properties of solids and modelling the chemical and physical processes going on in the atmospheres of evolved stars. Considerable progress has been achieved, during the past decade, in solid state astropyhsics; specific questions have arisen which necessitate new, dedicated measurements and observations. Here we highlight some aspects of this progress and then proceed to outlining insights in this field which are about to be attained by means of new satellite facilities such as Spitzer and Herschel.
Instrumentation Data Sheet .......................... 10 Figure 8. Human Physiology Screen One ....................................... 1I1 Figure 9. Human ... Physiology Screen Two...................................... 12 Figure 10. Human Physiology Screen Three ..................................... 12 Figure...Short-Latency Somatosensory Evoked Potentials in Impact Acceleration Research ***** HUMAN PHYSIOLOGY SCREEN***** Please Read First To move from one
Jakobiec, F A; Mills, M D; Hidayat, A A; Dallow, R L; Townsend, D J; Brinker, E A; Charles, N C
This article describes six patients who presented, usually bilaterally, with yellow-orange, elevated, indurated, and nonulcerated xanthomatous eyelid lesions, typically extending into the anterior orbital fat, and sometimes involving the extraocular muscles and the lacrimal gland. Because the eyelids remained intact and because the process did not reach the deep orbital and perioptic connective tissues, visual acuity was well preserved. There is cosmetic morbidity and occasionally motility restriction with advancing involvement of the extraocular muscles. All patients had variably severe adult-onset asthma that required treatment with systemic prednisone and inhalants. No evidence of Erdheim-Chester disease was found in any patient, but the appearance in one patient, after 25 years of follow-up, of a separate subcutaneous necrobiotic xanthogranulomatous lesion in the mandibular region with an associated paraproteinemia, suggests that at least some of our cases might be a mild form of necrobiotic xanthogranuloma. For this reason, we would suggest repeated periodic serum protein immunoelectrophoretic studies as well as evaluation for lymphoma. Therapy probably should consist of low doses of periorbital radiotherapy coupled with high doses of corticosteroids. Should this not be successful, then systemic administration of corticosteroids with chemotherapeutic agents might be efficacious, as in necrobiotic xanthogranuloma. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 PMID:8140711
Robb, R.A.; Heffeman, P.B.; Camp, J.J.; Hanson, D.P.
The capability to extract objective and quantitatively accurate information from 3-D radiographic biomedical images has not kept pace with the capabilities to produce the images themselves. This is rather an ironic paradox, since on the one hand the new 3-D and 4-D imaging capabilities promise significant potential for providing greater specificity and sensitivity (i.e., precise objective discrimination and accurate quantitative measurement of body tissue characteristics and function) in clinical diagnostic and basic investigative imaging procedures than ever possible before, but on the other hand, the momentous advances in computer and associated electronic imaging technology which have made these 3-D imaging capabilities possible have not been concomitantly developed for full exploitation of these capabilities. Therefore, we have developed a powerful new microcomputer-based system which permits detailed investigations and evaluation of 3-D and 4-D (dynamic 3-D) biomedical images. The system comprises a special workstation to which all the information in a large 3-D image data base is accessible for rapid display, manipulation, and measurement. The system provides important capabilities for simultaneously representing and analyzing both structural and functional data and their relationships in various organs of the body. This paper provides a detailed description of this system, as well as some of the rationale, background, theoretical concepts, and practical considerations related to system implementation. ImagesFigure 5Figure 7Figure 8Figure 9Figure 10Figure 11Figure 12Figure 13Figure 14Figure 15Figure 16
Reichert, C. M.; O'Leary, T. J.; Levens, D. L.; Simrell, C. R.; Macher, A. M.
The acquired immune deficiency syndrome (AIDS) is a devastating new illness which appears to be sexually and parenterally transmissible. AIDS was first described in the male homosexual community; however, the disease has more recently been described among intravenous drug abusers, Haitians, hemophiliacs, and others. The etiologic agent is unknown. AIDS may represent an infection by a previously undescribed organism, a mutant of a known microorganism, or a multifactorial combination of environmental, immunologic, and genetic factors. As a consequence of the disease's seemingly irreversible ablation of the cell-mediated immune system, AIDS victims succumb to a variety of infections and/or unusual neoplasms. In its fully developed form, mortality approaches 100%. At autopsy the gross and microscopic pathology of the syndrome can be divided into three general categories: 1) morphologic manifestations of profound lymphoid depletion; 2) infections, usually with mixed opportunistic pathogens; and 3) unusual neoplasms, most frequently Kaposi's sarcoma or high-grade lymphomas. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 PMID:6311021
Wilk, Kevin E.; Arrigo, Christopher; Andrews, James R.; Clancy, William G.
Objective: To discuss the rehabilitation program after anterior cruciate ligament (ACL) reconstruction in the female athlete. In addition, we will discuss 8 unique characteristics identified in the female athlete and specific training drills to address and correct the potentially deleterious effects of these unique characteristics. Background: The female athlete appears to be more susceptible to noncontact ACL injuries than the male athlete. There seem to be many differences between the female and male athlete that may contribute to the increased injury rate in the female athlete. These variations include anatomical and neuromuscular considerations and differences. Description: Based on the unique characteristics of the female athlete and the anatomical and neuromuscular dissimilarities, a specially designed rehabilitation program has been established for the female athlete after ACL surgery. Clinical Advantages: The rehabilitation drills discussed in this article challenge the neuromuscular system through proprioception, kinesthesia, dynamic joint stability, neuromuscular control, and perturbation training activities. Improving the female athlete's neuromuscular system will, we believe, expedite the injured athlete's recovery after ACL injury or surgery. Although the concepts discussed are part of a postoperative rehabilitation program after ACL surgery, these concepts may also be implemented as a preventive program to assist in reducing the incidence of ACL injuries in the female athlete. ImagesFigure 1.Figure 2.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12.Figure 13.Figure 14.Figure 15.Figure 16.Figure 17.Figure 18.Figure 19.Figure 20.Figure 21.Figure 22.Figure 23. PMID:16558561
Sweeny, P. R.; Brown, R. G.
This paper presents an ultrastructural study of the changes occurring in the gastrocnemius tendon of normal and selenium-deficient ducklings from 1 to 12 days of age. The study revealed that the normal 1--8-day-old duckling tendon contained 2 morphologically distinct cell types and a third occurring at Days 8--12. The location of these cells within the endotendineum and fiber bundles and their morphologic characteristics are presented. Most cells showed cytologic alterations as early as 4 days on the deficient diet with progressive deterioration to Day 12. The various cell types showed a differential response to the deficiency. Changes included altered endoplasmic reticulum and Golgi apparatus and eventual cell rupture. The significance of these observations and their possible relationship to the etiology of selenium-deficiency-induced dystrophy is discussed. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:7234963
Hargis, A. M.; Haupt, K. H.; Hegreberg, G. A.; Prieur, D. J.; Moore, M. P.
Familial canine dermatomyositis is a recently identified disease of collie dogs that resembles human juvenile dermatomyositis. The lesions in the skin and muscles obtained by biopsy from two litters of dogs were characterized for the purpose of determining the similarity of the lesions to those of human dermatomyositis. The cutaneous lesions began between 7 and 11 weeks of age and were present on the face, lips, ears, and skin over bony prominences of the limbs, feet, sternum, and tip of the tail. Histologically the cutaneous lesions frequently consisted of vesicles, pustules, and ulcers on the lips, face, and ears. Neutrophils, lymphocytes, mast cells, and macrophages were present throughout the dermis. Neutrophils and lymphocytes were also present in and around vessels. Between 13 and 19 weeks of age generalized muscle atrophy was noted. The muscle lesions consisted of interstitial lymphocyte, plasma cell, macrophage, and neutrophil accumulation; myofiber degeneration, regeneration, and atrophy; and fibrosis. Perivascular neutrophils, lymphocytes, and plasma cells were also seen. Histologically, the lesions resembled those present in human juvenile dermatomyositis; and these observations, coupled with clinical, immunologic, and clinical pathologic observations presented elsewhere, suggest that familial canine dermatomyositis is an appropriate and potentially useful model for human juvenile dermatomyositis. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 PMID:6465285
Keating, Joseph C
This paper provides a cursory overview of attempts to discover, preserve and disseminate the history of the chiropractic profession, up to and including the organization of the Association for the History of Chiropractic (AHC). A surprisingly wide range of materials have been available for many decades, but sustained efforts at historical scholarship are more recent (past quarter century). The quality of these works has been uneven, but has improved with the emergence of chiropractic scholarly periodicals and interest from non-chiropractor investigators. Affiliates of the American-based AHC are located in Australia and Canada; organized historical scholarship in other regions of the world has yet to develop. Several substantial archival resources for historical investigations are available, and merit greater scrutiny and support within the profession. ImagesFigure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 12Figure 13Figure 14Figure 15Figure 16Figure 17Figure 18Figure 19Figure 20Figure 21Figure 22Figure 23Figure 24Figure 25p136-ap136-bp136-cp136-dp136-e
Godfrey, W A
The experimental studies performed on nonpigmented rat choroids and the review of the important literature covered in this thesis seem to justify the following statements: 1. Mast cells are present in the choroid in significant numbers. 2. Mast cell numbers vary considerably from one individual to another and from one location in the choroid to another. 3. The major concentration of mast cells in the uvea is in the posterior choroid. 4. The mast cells of the choroid have a preferential location along arterial vessels. 5. Choroidal mast cell population density apparently decreases with senescence. 6. Mast cell products are present in sufficient quantity to exert substantial effects on physiologic, immunologic, and inflammatory responses in the choroid. 7. Choroidal mast cell products are released with appropriate stimulation and share some properties with the connective-tissue mast cell. 8. Choroidal mast cell demonstrate enough differences to suggest that a local differentiation may be present and may represent a locally controlled modulating effect for choroidal physiologic, immunologic, and inflammatory reactions. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 PMID:3328921
Koch, O. R.; Roatta de Conti, L. L.; Bolaños, L. P.; Stoppani, A. O.
To study the morphologic and biochemical changes occuring in liver mitochondria during recovery from ethanol-induced injury, rats fed a 6-month high-alcohol regimen plus a nutritionally adequate diet which did not induce fatty liver were compared with isocalorically fed controls. After this period the alcohol-fed animals displayed striking ultrastructural changes of liver mitochondria and a decreased respiratory activity with succinate or malate-glutamate as substrate. On the contrary, the respiratory rate with I-glycerophosphate was 50% increased. Regression changes were studied after alcohol was withdrawn from the diet. Enlarged mitochondria rapidly disappeared (in 24 hours), although a few megamitochondria were still present after 8 days of abstinence. A similar recovery was observed for the functional alterations. At the end of the experimental period, only a slight decrease of the maximal respiratory rate using malate-glutamate as a substrate was noted. The ultrastructural findings and the morphometric data suggest that the way in which mitochondrial normalization takes place is based on partition of these organelles. Images Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 1 Figure 2 Figure 13 PMID:623205
Hilbert, S. L.; Ferrans, V. J.; McAllister, H. A.; Cooley, D. A.
Studies were done on the structural changes that develop in Ionescu-Shiley valves that are used as replacement heart valves for 4 to 8 years. These changes were compared with those found in similarly used porcine aortic valve (PAV) bioprostheses. A variety of morphologic differences were observed between bovine pericardial valve (BPV) and PAV bioprostheses after orthotopic implantation including: primary tissue failure associated with the use of an alignment suture, thickening of valve leaflet, leaflet tissue delamination, leaflet calcification, and dystrophic alterations of collagen. These findings indicate that valve design criteria directly influence the durability of pericardial valves. However, other factors unique to pericardial tissue also affect the durability and performance of BPVs. These factors include the inability of pericardial tissue to accommodate dynamic stresses; the extensive insudation of plasma proteins and lipids; and the inability to reduce leaflet calcification using agents that effectively mitigate calcification in PAV bioprostheses. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 PMID:1580331
Lee, K. P.; Barras, C. E.; Griffith, F. D.; Waritz, R. S.
Rats, hamsters, and guinea pigs were exposed by inhalation to different concentrations of potassium octatitanate fibers. Following 3 months of exposure, the animals were sacrificed between the 15th and 24th month. The exposed animals showed dose-related dust deposition and pulmonary fibrosis mainly in the respiratory bronchiolar region. Most short fibers (less than 5 micrograms) were phagocytized by alveolar macrophages, but long fibers (greater than 10 micrograms) were phagocytized by foreign body giant cells. Dust-laden macrophages (dust cells) entered into the lumen of bronchial lymphatic or pulmonary blood vessels. Numerous dust cells were transported from the lung to the tracheobronchial and mediastinal lymph nodes where some dust cells penetrated into the blood or lymphatic circulation. Massive direct cell migration of the mediastinal adipose tissue from the lymph nodes occurred occasionally. Dust-laden giant cells were found only occasionally in the liver, and there was widespread migration of the fibers into other vital organs and tissues without any significant responses. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 PMID:7212016
Kameya, T.; Shimosato, Y.; Adachi, I.; Abe, K.; Kasai, N.; Kimura, K.; Baba, K.
Eighteen cases of medullary carcinoma of the thyroid were analyzed immunohistochemically for calcitonin- and ACTH-containing cells, and tumor cells in 8 cases were examined by an electron microscope and analyzed by manual and computer procedures with particular attention paid to the size and quality of secretory granules. Calcitonin- and ACTH-containing cells were found singly or in clusters in 14 and 11 tumors, respectively. In 4 cases, calcitonin-positive cell clusters and an increase in number of singly scattered C cells were seen apart from the main tumor, suggesting a multicentric nature of certain medullary carcinomas. Some ACTH-containing cells were apparently also positive for calcitonin. In a case of familial Sipple disease, follicular lining cells were replaced in areas with ACTH-containing cells. Three to five frequency distribution curves of the size of secretory granules were obtained in all of 6 cases analyzed, and at least two different types of granule matrix were identified. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 PMID:202164
Konrad, H; Merriam, J C; Jones, I S
PURPOSE: This paper describes the surgical rehabilitation of a child with craniofacial anomalies, unilateral syndactyly, and partial unilateral cryptophthalmos associated with inferior colobomata of the iris and optic nerve and agenesis of the inferior rectus and inferior oblique muscles. The clinical presentation of cryptophthalmos is described. METHODS: The medical literature since the original description of cryptophthalmos in 1872 was reviewed to define patterns of inheritance and the incidence of associated anomalies. RESULTS: Including this patient, 149 case reports of cryptophthalmos were identified. In two families transmission from parent to child suggests dominant inheritance. None of the five dominant cases had any other anomalies, and all had bilateral complete cryptophthalmos. The incidence of cryptophthalmos in the remaining families is consistent with autosomal recessive inheritance. This group includes patients with bilateral, unilateral, and partial cryptophthalmos. Other anomalies are common, including those of the ear and nose, limbs, genitourinary system, and mouth and palate. Mortality in the perinatal period is associated with renal agenesis, laryngeal atresia, and pulmonary hypoplasia. CONCLUSIONS: Cryptophthalmos is a rare congenital anomaly with two patterns of inheritance. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 PMID:8719680
Richards, R J; Curtis, C G
The sequence of cellular and biochemical events in response to the deposition of dust particles in lung tissue is described. Primary reactions at the lung surface include changes in the free cell population, the alveolar surface protein and in the quantity of pulmonary surfactant, a lipoprotein-rich material secreted by Type II cells. The relationship between these changes and lung fibrogenesis is discussed. It is suggested that such primary changes are protective mechanisms which may assist in the prevention of fibrogenesis rather than lead to an increase in collagen formation and deposition. If these primary defenses are overcome, then the interstitial fibroblastlike cell may have a prominent role in fibrogenesis. Therefore detailed observations of the interaction between lung fibroblasts and mineral dusts in vitro are described. As fibrogenesis may be arrested in vivo, or possibly reversed, and does not always progress to fibrosis, final consideration is given to the step from fibrogenesis to fibrosis. It is suggested that this step may involve other tissue proteins apart from collagen and that the irreversible nature of fibrosis can be explained by the formation of strong intermolecular crosslinks between different proteins. The types of crosslinks that may be involved are discussed. Emphasis is placed on the role of calcium-dependent transglutaminases in fibrosis, as these enzymes have hitherto received little attention. Images FIGURE 3. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 20. FIGURE 21. FIGURE 22. FIGURE 23. PMID:6376109
Tomashefski, J. F.; Davies, P.; Boggis, C.; Greene, R.; Zapol, W. M.; Reid, L. M.
Specimen arteriography, morphometry, and light and electron microscopy were used for examination of the pulmonary vasculature of 22 patients who died with the adult respiratory distress syndrome (ARDS), for the purpose of defining the lesions that contribute to pulmonary hypertension in this setting. The different lesions correlated with the duration rather than the cause of ARDS. Thromboemboli occurred in 21 patients, and macrothrombi found at autopsy correlated with the number of filling defects on antemortem angiography. Acute endothelial injury was documented ultrastructurally even in intermediate and late-stage patients. Fibrocellular intimal obliteration of arteries, veins, and lymphatics and infective vasculitis were prominent in those surviving beyond 10 days. In long-term survivors, tortuous arteries and irregularly dilated capillaries were striking features. Peripheral extension of vascular smooth muscle and a significant increase in the percentage of medial thickness of muscular arteries with duration of ARDS were noted. The pathogenesis and clinical significance of these lesions is discussed. Images Figure 1 Figure 2 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:6859225
Speers, W. C.; Birdwell, C. R.; Dixon, F. J.
N,N-dimethylacetamide, hexamethylene bisacetamide, and Polybrene induced rapid and extensive differentiation in vitro in an otherwise slowly differentiating subline of embryonal carcinoma cells. The type of differentiated cell induced was dependent on the spatial organization of the stem cells during drug treatment. In monalayer culture "epithelial" cells were produced exclusively. However, treatment of aggregated suspension cultures yielded predominantly "fibroblast-like" cells. The undifferentiated embryonal carcinoma cells and the two differentiated cell types were morphologically distinct when examined by light microscopy, scanning electron microscopy, and transmission electron microscopy; and they had differences in cell surface antigens. Both differential cell types produced large amounts of fibronectin, whereas the embryonal carcinoma cells produced only minimal amounts. This system provides a convenient way to induce relatively synchronous differentiation of embryonal carcinoma cells into specific differentiated cell types. Images Figure 5 Figure 6 Figure 1 Figure 2 Figure 3 Figure 4 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:507191
Merriam, J C; Stalnecker, M C; Merriam, G R
The initial stages in the rehabilitation of a male child with severe microblepharon, corneal opacities, bilateral facial clefts, bilateral complete cleft lip and palate, and unilateral syndactyly are described. Review of the literature suggests that severe microblepharon is associated with other craniofacial anomalies, and often the child is stillborn or retarded. Surviving children have been abandoned because of their appearance. The child described in this case appears to be unique because his intelligence is normal, and, to our knowledge, this is the first reported case of penetrating keratoplasty after reconstruction of functional eyelids. The principal problems after corneal grafting appear to have been chronic partial exposure due to inadequate lid length and a poor Bell's reflex and the persistence of a rim of vascularized fibrous tissue around the corneal graft. Future reconstructive surgery is outlined. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 PMID:2979029
Brody, A R
The mineral pneumoconioses (lung disease caused by inhalation of inorganic dust) have been an important disease entity for centuries. In the last several decades, the electron microscope has been used to elucidate the distribution and identification of inhaled minerals, to aid in establishing etiologic factors, and less commonly, to determine the basic biologic mechanisms through which inhaled minerals cause lung disease. In this section, I review the instrumentation and tissue preparation currently used to address some modern problems in particle-induced lung disease. For example, human pneumoconioses of undetermined etiology can be clarified by electron microscopy and X-ray energy spectrometry. In addition, the initial deposition patterns of asbestos and silica are demonstrated in animal models, and the contributions of electron microscopy in establishing the initial lesions of asbestosis are described. Images FIGURE 1. FIGURE 2. FIGURE 3. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 13. FIGURE 14. PMID:6090114
Faraggiana, T.; Churg, J.; Grishman, E.; Strauss, L.; Prado, A.; Bishop, D. F.; Schuchman, E.; Desnick, R. J.
A histochemical study was performed on light- and electron-microscopic level in a case of Fabry's disease. The patient underwent kidney transplantation for renal failure and died of heart failure 6 months later. Patient's tissues were studied at the light- and electron-microscopic levels with various embedding and staining techniques for lipids and carbohydrates. Two peroxidase-labeled lectins (from Ricinus communis and from Bandeiraea simplicifolia) known to have affinity for alpha- and beta-D-galactose, were strongly reactive with the storage material on frozen sections. The ultrahistochemical and extraction tests showed that the typical granules had a variable reactivity and morphologic characteristics in different cells, probably reflecting different composition. A small number of typical deposits were also observed in the transplanted kidney. This is the first reported case of recurrence of the storage disease in the allograft. Of interest was also the fact that the patient's blood inhibited normal alpha-galactosidase activity, suggesting a possible inhibitor-related mechanism in the pathogenesis of the recurrence. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 PMID:6786101
Shaw, J. O.
Lung inflammation was induced in rabbits by intratracheal injections of chemotactic fragments obtained from zymosan-activated serum (CF-ZAS), and the route of vascular emigration and alveolar surface interaction of polymorphonuclear leukocytes (PMNs) and monocytes migrating into the lung was characterized by transmission (TEM) and scanning (SEM) electron-microscopic examination. Leukocytes migrated from capillaries and venules into the alveolar wall interstitium by adherence to the vascular endothelium and migration through the endothelial intracellular junction to attain a position between a reapposed endothelial cell junction and the vascular basement membrane. The cells then migrated into the interstitium through a narrow opening in the basement membrane. Leukocyte entrance into the alveolar space from the interstitium appeared to occur through small openings in the epithelial basement membrane at or near the Type I epithelial intercellular junction. Once in the alveolus, PMNs and macrophages demonstrated surface adherence and spreading along with evidence of migration, pseudopod extension, interalveolar pore transit, and retraction fiber formation. This study indicates the leukocyte influx into the alveolus in acute chemotactic-factor-induced inflammation is via a continuum of migrational activity, beginning at the pulmonary capillary endothelial surface and persisting on the alveolar epithelial surface. Images Figure 10 Figure 11 Figure 12 Figure 1 Figure 2 Figure 3 Figure 13 Figure 14 Figure 4 Figure 5 Figure 6 Figure 15 Figure 7 Figure 8 Figure 16 Figure 9 PMID:7435538
Zafrani, E. S.; Cazier, A.; Baudelot, A. M.; Feldmann, G.
Ultrastructural lesions of the liver were studied in 12 patients with peliosis hepatis. This vascular lesion consisted of cavities filled with red blood cells and sometimes lined with an endothelial barrier; the cavities were due to cystic dilatation of the space of Disse and/or sinusoidal lumen. The passage of red blood cells through the endothelial barrier was occasionally demonstrated. Other striking alterations included the presence of numerous blebs on the sinusoidal membrane of the hepatocytes and the existence of multiple cellular layers lining the sinusoids. Perisinusoidal fibrosis appeared on follow-up biopsies in 3 patients. There was no major abnormality of the hepatocytes or of the hepatic venules. These findings suggest that alterations of the sinusoidal barrier might constitute the primary event in peliosis, although secondary changes to increased pressure and hypoxia within the lobules cannot be excluded. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:6696047
White, J. G.
The gray platelet syndrome (GPS) is a rare inherited disorder in which peripheral blood platelets are relatively large, vacuolated, and almost devoid of cytoplasmic granulation. In the present study we have evaluated the ultrastructure and cytochemistry of platelets from 2 patients with the GPS to determine precisely which organelles are missing from their cells. The findings indicate that gray platelets contain normal numbers of mitochondria, dense bodies, peroxisomes, and lysosomes but specifically lack alpha-granules. Preliminary studies of megakaryocytes from 1 of the 2 patients suggest that the defect in granule formation may lie at the level of the Golgi zone. Images Figure 15 Figure 16 Figures 17 and 18 Figures 19 and 20 Figure 3 Figure 4 Figures 5 and 6 Figures 7 and 8 Figure 27 Figure 28 Figure 29 Figure 30 Figure 31 Figure 32 Figure 9 Figure 10 Figure 11 Figure 12 Figures 13 and 14 Figures 21 and 22 Figures 23 through 26 Figure 1 Figure 2 PMID:453324
Chadee, K.; Meerovitch, E.
The pathogenesis of experimentally induced cecal amebiasis in gerbils (Meriones unguiculatus) was studied from 5 to 60 days after inoculation. Ulcerative lesions were noted 10 to 60 days after inoculation. The sequential development of lesions was asynchronous and progressed from destruction of the interglandular epithelium and of glandular crypt elements to loss of mucosa and formation of granulomatous lesions in the submucosa involving the muscularis mucosae. Pathologic changes in the liver correlated with the formation of ulcerative cecal lesions. Subacute hepatic changes showed lymphocytic portal infiltrate, Kupffer cell hyperplasia, multinucleated giant cells, granuloma formation, and sinusoidal mononuclear and granulocytic infiltrates. Metastatic amebic liver abscesses occurred as early as 10 days after inoculation, and small abscesses were found in the portal areas of the right liver lobe. The sequential development and pathologic manifestation of the infection and the usefulness of the gerbil for the study of human intestinal amebiasis are discussed. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 PMID:4014436
Chadee, K.; Meerovitch, E.
Sequential development and pathology of experimentally induced amebic liver abscess in the gerbil (Meriones unguiculatus) were studied from 1 to 60 days after inoculation. Early lesions were characterized by an acute inflammatory response, which became granulomatous at 5 days. Early granulomas were discrete, with well-defined fibrohistiocytic walls. Trophozoite dissemination as a result of fibrolysis of granuloma wall was confined to the liver parenchyma. The granulomatous cellular infiltrate (less than 20 days) was characterized by granulocytes and histiocytes; older granulomas (greater than 30 days) were composed of lymphocytic infiltrate, plasma cells, and a few granulocytes, and were characterized by the absence of epithelioid histiocytes. The degree of pathologic change adjacent to liver granulomas followed the sequential development of the amebic liver abscess. Severe changes observed were portal canal lymphocytic infiltration, the presence of foreign body giant cells, periportal fibrosis, proliferation of bile duct epithelium, and hepatocyte anisonucleosis and ballooning degeneration. The pathogenesis of the infection and the usefulness of the gerbil model for the study of human amebiasis are discussed. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 PMID:6385727
Harris, G J
The clinical course of SPA of the orbit is associated with the age of the patient. That association might be explained through a series of intermediate relationships: the clinical course correlates with the bacterial constituency, the bacterial constituency is related to physiologic derangement within the sinuses, the physiologic derangement may vary with the degree of obstruction of the sinus ostia, and the ostial caliber relative to the volume of the cavity that must be drained decreases with patient age into late adolescence. The controversy between pediatricians and surgeons over the appropriate indications for drainage might be resolved with the acknowledgement that each side is correct on the basis of the patient populations treated. It is hoped that recognition of the age-related variations in SPA will permit a more systematic approach to the management of this complex infectious disease. Images FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 PMID:8140703
Gulizia, J. M.; Cunningham, M. W.; McManus, B. M.
Association of group A streptococci with acute rheumatic fever and valvular heart disease is well established; however the basis of valve injury remains unclear. In this study, anti-streptococcal monoclonal antibodies (MAbs) cross-reactive with myocardium were reacted with sections from 22 rheumatic valves, nine normal, five endocarditic, one 'floppy,' and one Marfan valve. In immunohistochemical studies, MAb reactivity was observed with cardiac myocytes, smooth muscle cells, cell surface and cytoplasm of endothelial cells lining valves, and valvular interstitial cells. Endothelial basement membrane and elastin fibrils reacted with the MAbs, whereas collagen was unreactive. Similar reactivity was seen with sera from acute rheumatic fever patients. The anti-streptococcal MAbs reacted with intravalvular myosin and vimentin in Western blots, and purified elastin competitively inhibited the binding of the anti-streptococcal MAbs to whole group A streptococci. The data show that human heart valves have numerous sites of immunoreactivity with anti-streptococcal MAbs and acute rheumatic fever sera of potential importance in the pathogenesis of rheumatic valvular injury. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:1704188
Rossi, M. A.; Gonçalves, S.; Ribeiro-dos-Santos, R.
In male BALB/c mice aged 5-6 weeks inoculated three times at intervals of 15 days with 1 X 10(7) epimastigote forms of the PF strain of Trypanosoma cruzi and challenged 30 days after the last inoculation with 2 X 10(4) trypomastigote forms of the Colombia strain of T cruzi (the mice were sacrificed 80-100 days after the challenge) a cardiomyopathy very similar to that observed in the chronic phase of Chagas' disease in man develops. The cardiac syndrome is characterized grossly by cardiomegaly with hypertrophy, dilatation of ventricular chambers, and thinning of the apex of the left ventricle (apical aneurysm) and microscopically by focal areas of myocytolytic necrosis and myocardial degeneration with an inflammatory response composed of mononuclear cells (predominantly macrophages and a few lymphocytes) with concurrent interstitial fibrosis and occasional myofibers containing pseudocysts. In addition, aggregated platelets and occlusive thrombi were found in small epicardial and intramyocardial vessels of infected mice as compared with controls. The potential role of intravascular platelet aggregation in the causation of focal myocardial necrosis and degeneration and apical aneurysm in experimental T cruzi cardiomyopathy in BALB/c mice is discussed. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:6230012
Shulman, H. M.; Sale, G. E.; Lerner, K. G.; Barker, E. A.; Weiden, P. L.; Sullivan, K.; Gallucci, B.; Thomas, E. D.; Storb, R.
This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, ie, de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and subcutaneous fibrosis, and contractures. Microscopically, it resembled generalized morphea and lupus erythermatosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed. Images Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 1 Figure 2 Figure 3 Figure 4 PMID:26221
Vande Berg, J. S.; Robson, M. C.; Mikhail, R. J.
Recombinant human interleukin-1 beta (rhuIL-1 beta) was investigated in a randomized, blinded placebo-controlled trial to evaluate its effect on the healing of chronic pressure ulcers. The influence of this topically applied cytokine to 26 pressure ulcer patients was correlated with tissue culture and electron microscopic evaluation. Cellular replication studies showed that low (0.01 micrograms/cm2/day) and medium (0.1 micrograms/cm2/day) concentrations of rhuIL-1 beta were not effective in extending replication in pressure ulcer fibroblasts, in vitro. Tissue culture measurements from pressure ulcer biopsies demonstrated that, after 29 days of a high level of rhuIL-1 beta treatment (1.0 micrograms/cm2/day), the cytokine was effective in extending the ability of pressure ulcer fibroblasts to replicate. Tissue culture and electron microscopy suggested that, although rhuIL-1 beta promoted increases in fibroblast numbers, the primary effect appeared to be development of the extracellular matrix. The possible direct and indirect influences of rhuIL-1 beta therapy on pressure ulcers are discussed. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:7747819
The current study traces the development of contractile cells in the nonmuscular segments of rat lung microvessels in hyperoxic pulmonary hypertension. New intimal cells first develop into a well-defined layer beneath the endothelium and internal to an elastic lamina. Ultrastructurally, these cells are found to be 1) fibroblasts recruited to the vessel wall from the interstitium and 2) intermediate cells, a population of preexisting vascular cells (structurally between a smooth muscle cell and a pericyte). Early in hyperoxia (days 3 through 7), interstitial fibroblasts migrate and align around the smallest vessels in which an elastic lamina is either absent or fragmentary. These cells then are incorporated into the vessel wall by tropoelastin secretion and the formation of an elastic lamina along their abluminal margin. After day 7, the new mural fibroblasts acquire the features of contractile cells, namely a basal lamina, extensive microfilaments, and dense bodies. In other vessels, as early as day 3 of hyperoxia, intermediate cells within the vessel intima begin to acquire the additional filaments and dense bodies of contractile cells. As hyperoxia continues, each cell pathway gives rise to vessels with distinct intimal or medial layers of contractile cells. In this way, thick-walled 'newly muscularized' vessel segments form adjacent to the capillary bed. Images Figure 1 Figure 5 Figure 6 Figure 7 p1500-a Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:1466406
Van Vleet, J. F.; Ferrans, V. J.
Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atrial lesions. On days 1-4, extensive necrosis with contraction bands was present. Rapid macrophagic invasion and phagocytosis of sarcoplasmic debris was seen on days 2 and 4. Missing necrotic myocytes were outlined by persistent "tubes" of external laminas. In some surviving myocytes, sublethal injury was evident on day 1 by mitochondria with condensed conformation and on days 2, 4, and 16 by moderate to marked myofibrillar lysis and sarcoplasmic vacuolation. Monensin cardiotoxicity in pigs constitutes a unique example of selective injury to atrial myocardium. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:6696048
Maxwell, W. A.; Spicer, S. S.; Miller, R. L.; Halushka, P. V.; Westphal, M. C.; Setser, M. E.
By light microscopy the subdermal nodule of a patient with fibrodysplasia ossificans progressiva (FOP) had a fibromatoid histologic appearance. The cytoplasm of the cells stained strongly for mannose-rich glycoprotein with the concanavalin A-horseradish peroxidase (con A-HRP) method. The tumors also exhibited abundant hyaluronidase-digestible mucopolysaccharide in the interstitium with various basic staining reagents. This material appeared to consist principally of hyaluronic acid or chondroitin sulfate with few or mainly masked sulfate esters. At the ultrastructural level, cells interpreted as the tumor cells in the subdermal nodule from the patient displayed extremely hyperplastic granular reticulum and well-developed Golgi elements and appeared very active in synthesis and secretion of protein. The material in the dilated cisternae of the granular reticulum stained for glycoprotein with the con-A-HRP method. Macrophages which comprised the other main cell type in the nodules commonly contacted the tumor cells and occasionally evidenced engulfment of these cells. The intercellular matrix of the nonossified subdermal nodule exhibited greatly increased mucosubstance and, by electron microscopy, showed an unusual network of dialyzed iron-reactive acid muco-substance in the interstitium. Images Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figures 15-16 Figure 17 Figure 18 Figure 1 Figures 2-3 PMID:141214
Sibley, R. K.; Sutherland, D. E.
The authors examined tissues obtained by biopsy, pancreatectomy, and autopsy from 100 pancreas grafts to determine the cause of dysfunction or failure of the graft. Immunohistologic examination of 42 tissues to determine the mononuclear cell phenotypes and Class I and II antigen expression was performed as well. Technical factors--infections, thrombosis, obstruction--accounted for a large number of graft losses, but immunologic-mediated mechanisms resulted in graft dysfunction and failure as well. Pleomorphic inflammatory infiltrates were present in grafts with acute rejection, as well as Silastic and Prolamine duct-obstructed grafts. Criteria useful in the identification of acute rejection from pancreatitis included a more intense, predominantly mononuclear cell infiltration of transformed lymphocytes in the exocrine pancreas and evidence of vascular rejection--endovasculitis or fibrinoid necrosis. Increased expression and/or induction of Class I and II antigens on pancreatic constituents occurred in grafts with evidence of acute rejection, but also with Silastic and prolamine duct-obstructed pancreatitis. An isletitis occurred in 25% of the grafts. Nine of the 25 grafts (36%) with isletitis also had selective loss of beta cells from the islets. Recurrent diabetes mellitus appeared to have developed in these cases, which accounted for loss of graft function. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:3037911
Fobi, M. A. L.
Obesity is a chronic disease due to excess fat storage, a genetic predisposition, and strong environmental contributions. This problem is worldwide, and the incidence is increasing daily. There are medical, physical, social, economic, and psychological comorbid conditions associated with obesity. There is no cure for obesity except possibly prevention. Nonsurgical treatment has been inadequate in providing sustained weight loss. Currently, surgery offers the only viable treatment option with longterm weight loss and maintenance for the morbidly obese. Surgeries for weight loss are called bariatric surgeries. There is no one operation that is effective for all patients. Gastric bypass operations are the most common operations currently used. Because there are inherent complications from surgeries, bariatric surgeries should be performed in a multidisciplinary setting. The laparoscopic approach is being used by some surgeons in performing the various operations. The success rate--usually defined as >50% excess weight loss that is maintained for at least five years from bariatric surgery--ranges from 40% in the simple to >70% in the complex operations. The weight loss from surgical treatment results in significant improvements and, in some cases, complete resolution of comorbid conditions associated with obesity. Patients undergoing surgery for obesity need lifelong nutritional supplements and medical monitoring. Images Figure 4 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:14746355
Keating, Joseph C
John J. Nugent, D.C. is remembered by many as either the “Abraham Flexner of Chiropractic” or the “anti-Christ of Chiropractic.” From 1941 until his forced retirement in 1959, the Irish-born Palmer graduate was one of the most important factors in the profession's educational reforms. Yet Nugent's work as the National Chiropractic Association's (NCA's) director of research was not the beginning of the campaign to upgrade chiropractic education. This paper looks at earlier influences and events which set the stage for Nugent's campaign. Among these were the introduction of licensure for chiropractors, the self-defeating actions of B.J. Palmer, the introduction of basic science legislation, the lethargy of the schools, and the struggle for control of education between the schools, on the one hand, and the NCA and the Council of State Chiropractic Examining Boards on the other ImagesFigure 1Figure 3Figure 4Figure 5Figure 6Figure 7Figure 9Figure 10Figure 11Figure 12Figure 13Figure 14Figure 15Figure 16Figure 17Figure 18Figure 19Figure 20Figure 21Figure 22Figure 23Figure 24Figure 25Figure 26Figure 28Figure 29Figure 30Figure 31Figure 32Figure 33Figure 34Figure 35Figure 36Figure 37Figure 38
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66 References Used to Develop Catalog for Potential Biobased Products ......................... 66...based Feedstocks .... 10 Figure 3 Analogous Model of a Biobased Product Flow-chart for Biomass Feedstocks .... 11 Figure 4 Star Diagram of 3...profitability makes it more attractive for new biobased companies to contribute to our domestic fuel and power supply by reinvesting in new biorefineries
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Van Vleet, J. F.; Ferrans, V. J.; Weirich, W. E.
Chronic adriamycin (ADR) intoxication was produced in three groups of beagle dogs by weekly intravenous injections (1 mg/kg body weight) for 20 weeks (cumulative dose 400 mg/sq m). Group A (6 dogs) received ADR only; Group B (6 dogs) were given ADR and weekly doses of vitamin E (17 mg/kg body weight) as alpha-tocopherol acetate; and Group C (6 dogs) received ADR and weekly doses of vitamin E as did Group B and selenium (0.06 mg/kg body weight as selenite). Each of the 18 dogs developed ADR-induced cardiomyopathy (CMY), and death occurred in 11 dogs during Weeks 17-20. Mortality was lowest in Group B (2 of 6), but no differences between groups were seen either in survival time of the dogs that died or in severity of CMY. Cardiomyopathy was more severe in dogs that died than in survivors. Congestive heart failure with transudation was present in 4 of 11 dogs that died. Cardiac histopathology was characterized by vacuolar degeneration of myocytes. Myocardial damage was most severe in the left ventricle and the ventricular septum, intermediate in the right ventricle and the left atrium, and least in the right atrium. Ultrastructural study showed that an early alteration in damaged myocytes was distention of sarcoplasmic reticulum to form sarcoplasmic vacuoles. Occasional damaged fibers had myofibrillar lysis and focal proliferation of sarcoplasmic reticulum. This study demonstrates that the dog offers a suitable model for studies of chronic ADR cardiotoxicity in man. The lack of cardioprotection from vitamin E and selenium supplementation fails to support the proposed role of lipoperoxidative damage in the development of chronic ADR-induced CMY. Images Figure 9 Figure 10 Figure 1 Figure 2 Figure 11 Figure 12 Figure 13 Figure 3 Figure 4 Figure 5 Figure 14 Figure 15 Figure 6 Figure 7 Figure 8 Figure 16 Figure 17 Figure 18 Figure 19 PMID:7361854
Hard, G C; Rodgers, I S; Baetcke, K P; Richards, W L; McGaughy, R E; Valcovic, L R
This review paper examines the relationship between chemicals inducing excessive accumulation of alpha 2u-globulin (alpha 2u-g) (CIGA) in hyaline droplets in male rat kidneys and the subsequent development of nephrotoxicity and renal tubule neoplasia in the male rat. This dose-responsive hyaline droplet accumulation distinguishes CIGA carcinogens from classical renal carcinogens. CIGA carcinogens also do not appear to react with DNA and are generally negative in short-term tests for genotoxicity, CIGA or their metabolites bind specifically, but reversibly, to male rat alpha 2u-g. The resulting complex appears to be more resistant to hydrolytic degradation in the proximal tubule than native, unbound alpha 2u-g. Single cell necrosis of the tubule epithelium, with associated granular cast formation and papillary mineralization, is followed by sustained regenerative tubule cell proliferation, foci of tubule hyperplasia in the convoluted proximal tubules, and renal tubule tumors. Although structurally similar proteins have been detected in other species, including humans, renal lesions characteristic of alpha 2u-g nephropathy have not been observed. Epidemiologic investigation has not specifically examined the CIGA hypothesis for humans. Based on cancer bioassays, hormone manipulation studies, investigations in an alpha 2u-g-deficient strain of rat, and other laboratory data, an increased proliferative response caused by chemically induced cytotoxicity appears to play a role in the development of renal tubule tumors in male rats. Thus, it is reasonable to suggest that the renal effects induced in male rats by chemicals causing alpha 2u-g accumulation are unlikely to occur in humans. Images FIGURE 1. FIGURE 2. FIGURE 3. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 13. PMID:7686485
Anderson, D R
Tissue from ten eyes with infantile glaucoma and from 40 normal eyes of fetuses and infants without glaucoma were examined by light and electron microscopy. In normal development, the corneoscleral coat grows faster than the uveal tract during the last trimester, leading to a posterior migration of the ciliary body attachment from Schwalbe's line (5th month) to the scleral spur (9th month), and then to a location behind the scleral spur (postnatally). In infantile glaucoma, the insertion of the anterior ciliary body and iris overlaps the trabecular meshwork, similar to the late fetal position. The trabecular sheets are perforated, and there is no membrane over the surface of the trabecular meshwork. The trabecular beams are thicker than in normal infant eyes. There is both histologic and clinical evidence of traction on the iris root exerted by the thickened trabecular beams. These findings suggest that in congenital glaucoma the thickened beams had prevented the normal posterior migration of the ciliary body and iris root. This traction may compact the thickened trabecular beams, obstructing aqueous humor outflow. Release of the traction by an incision (goniotomy or trabeculotomy) of the thickened meshwork may relieve the obstruction. Of uncertain pathological significance is that there are no vacuoles in the endothelium of Schlemm's canal and there is a broad layer of collagen and amorphous material in the juxtacanalicular connective tissue. The ciliary processes are elongated inward, as if they were pulled by zonular traction (perhaps created by an enlarging diameter of the limbus with a fixed lens diameter). Images FIGURE 7 FIGURE 8 FIGURE 10 FIGURE 11 FIGURE 20 A FIGURE 20 B FIGURE 1 FIGURE 3 FIGURE 4 A FIGURE 4 B FIGURE 5 A FIGURE 5 B FIGURE 6 FIGURE 9 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 PMID:7342408
Abt, E; Suh, H H; Allen, G; Koutrakis, P
An intensive particle monitoring study was conducted in homes in the Boston, Massachusetts, area during the winter and summer of 1996 in an effort to characterize sources of indoor particles. As part of this study, continuous particle size and mass concentration data were collected in four single-family homes, with each home monitored for one or two 6-day periods. Additionally, housing activity and air exchange rate data were collected. Cooking, cleaning, and the movement of people were identified as the most important indoor particle sources in these homes. These sources contributed significantly both to indoor concentrations (indoor-outdoor ratios varied between 2 and 33) and to altered indoor particle size distributions. Cooking, including broiling/baking, toasting, and barbecuing contributed primarily to particulate matter with physical diameters between 0.02 and 0.5 microm [PM((0.02-0.5))], with volume median diameters of between 0.13 and 0.25 microm. Sources of particulate matter with aerodynamic diameters between 0.7 and 10 microm [PM((0.7-10))] included sautéing, cleaning (vacuuming, dusting, and sweeping), and movement of people, with volume median diameters of between 3 and 4.3 microm. Frying was associated with particles from both PM((0.02-0.5)) and PM((0.7-10)). Air exchange rates ranged between 0.12 and 24.3 exchanges/hr and had significant impact on indoor particle levels and size distributions. Low air exchange rates (< 1 exchange/hr) resulted in longer air residence times and more time for particle concentrations from indoor sources to increase. When air exchange rates were higher (> 1 exchange/hr), the impact of indoor sources was less pronounced, as indoor particle concentrations tracked outdoor levels more closely. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:10620522
Vyalov, S. L.; Gabbiani, G.; Kapanci, Y.
The majority of fibroblasts in alveolar septa are characterized by the presence of cytoplasmic bundles of microfilaments that contain cytoplasmic actin isoforms; these cells have been named contractile interstitial cells or V-type myofibroblasts. In the rat, they express desmin as intermediate filament protein. In this study, we explored the possibility that modulation and replication of such septal fibroblasts result in the appearance of alpha-smooth muscle (alpha-SM) actin-positive myofibroblasts, typical of lung fibrosis. Experimental pulmonary fibrosis was produced by a unique intratracheal instillation of bleomycin to 28 rats. Eight additional rats used as controls received the equivalent volume of saline. Paraffin and frozen sections of lungs were examined at days 1, 3, 5 and 7 after treatment. Microfilaments and intermediate filaments were stained using antibodies against total actin, alpha-SM actin, desmin, vimentin, keratin, and SM myosin. Electron microscopic labeling of desmin and alpha-SM actin using immunogold technique was done on Lowicryl K4M resin-embedded specimens. alpha-SM actin appeared in desmin-positive alveolar fibroblasts as early as 24 hours after intratracheal bleomycin instillation; the modulation of alpha-SM actin in these cells was preceded by a lymphomonocytic infiltration of alveolar septa. Twenty-four hours to 3 days after bleomycin administration, a proliferation of alveolar myofibroblasts occurred. Fibrosis with laying down of collagen fibers took place after the above mentioned cellular modifications. Our results support the view that septal fibroblastic cells can modulate into typical alpha-SM actin-containing myofibroblasts during experimental bleomycin-induced pulmonary fibrosis. In such a modulation a possible role of cytokines, particularly of transforming growth factor-beta, is considered. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14
Thiedermann, K. U.; Ferrans, V. J.
Alterations observed in the sarcoplasmic reticulum of muscle cells in left and right atrial myocardium from 10 patients with mitral valvular disease consisted of: a) proliferation of rough-surfaced endoplasmic reticulum, which formed large cisterns in perinuclear areas of hypertrophied cells and was considered indicative of increased protein synthesis; b) proliferation of free sarcoplasmic reticulum, a change that occurred in degenerated cells and appeared to be related to loss of contractile elements; c) two types of aggregates of tubules of free SR--one type was associated wtih abnormal Z-band material and was found only in cells showing loss of myofibrils and proliferation of free SR, whereas the other was not associated with either of these changes and occurred in less severely altered cells; and d) proliferation and enlargement of cisterns of extended junctional sarcoplasmic reticulum, which formed two distinct types of complexes: the first of these consisted of large, convoluted (Type A) cisterns that were wide (550 to 650 A in thickness) and did not have a central dense lamina; the second was composed of stacks of concentric or parallel (Type B) cisterns that were narrower (220 to 300 A in thickness), had a central dense lamina, and were separated from one another by layers of glycogen granules. The formation of these complexes of cisterns was regarded as an extreme form of overdevelopment of extended junctional sarcoplasmic reticulum in atrial muscle cells. Images Figure 21 Figures 22-25 Figures 1-3 Figures 26-29 Figure 4 Figure 5 Figure 6 Figures 30 and 31 Figure 7 Figure 8 Figure 9 Figure 10 Figures 32-36 Figure 11 Figure 12 Figures 37-39 Figure 15 Figure 16 Figure 17 Figure 13 Figure 14 Figures 40 and 41 Figure 18 Figures 19 and 20 PMID:1275054
Caldwell, D R
appearance. Images FIGURE 1 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 17A FIGURE 17B FIGURE 18 FIGURE 19 PMID:9440192
Albert, D M
Electron microscopic examination of 57 ocular melanomas (54 human, two feline and one canine) revealed the presence of viral particles in six specimens. Herpesviruses particles were observed in one human specimen and were passed in human fibroblasts (WI-38), where they gave rise to intranuclear inclusions. A-type oncornavirus particles (oncogenic RNA virus) were observed in a second case, both in cells of tumor directly removed from an enucleated eye as well as in cells grown in tissue culture. In three human specimens and one feline specimen, togavirus particles were observed. Rubella is a member of this group, and the possibility that the presence of togavirus in these tumors is the result of latent ocular infection by rubella virus is raised. Herpes virus and RNA tumor viruses are widely considered as having a possible etiologic role for certain human cancers. The observation of togavirus is unexpected, as this virus has not been previously implicated in human or animal tumors. Injection of an RNA tumor virus (Gardner strain feline sarcoma virus) into the anterior chamber of newborn kittens resulted in the development of iris and ciliary body melanomas, many of which showed invasion and, in one instance, metastasis. This is the first animal model of a viral-induced uveal melanoma, and the histology and ultrastructure are described. These results emphasize the need for the continued investigation of the role of these viruses in uveal melanoma. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 PMID:545833
Luxenberg, M N
An experimental study of nematode endophthalmitis due to T canis and review of the literature has been presented. Six owl monkeys were infected either by nasogastric tube using embryonated T canis eggs or by carotid or intravitreal injection of second stage larvae. The clinical manifestations, especially ocular, were observed and various diagnostic tests performed. Only minimal or no intraocular changes were seen after systemic infection but significant abnormalities such as retinal hemorrhages and venous dilation were noted after intravitreal infection. Motile larvae were observed in the lenses of three eyes and in the vitreous of five eyes and, probably a sixth, after intravitreal injection. The intensity and timing of the intraocular reaction seemed to correlate with the infecting dose and apparent disappearance of larvae from the eye. Pathologic confirmation of larvae in the lens was obtained in one eye. A marked inflammatory reaction occurred in eyes receiving intraocular infection but none was seen in eyes with only systemic infectin. Various laboratory and serologic studies were performed, including the ELISA test, which were used to evaluate systemic as well as intraocular responses to infection with T canis. The two monkeys infected by nasogastric tube gave a positive ELISA response in the serum but intraocular fluids gave a negative response in all monkeys including those infected syst:mically and/or intraocularly. Problems in the understanding of clinical aspects of the disease, laboratory diagnosis and treatment are discussed. The need for future experimental studies is emphasized. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 2 D FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 A FIGURE 6 B FIGURE 7 FIGURE 8 FIGURE 9 A FIGURE 9 B FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 PMID:120993
Rehm, S.; Takahashi, M.; Ward, J. M.; Singh, G.; Katyal, S. L.; Henneman, J. R.
pulmonary tumors of the hamsters progressed towards a squamoid cell type, CCA was no longer detectable but cells became immunoreactive for keratin. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:2464284
Bocan, T. M.; Guyton, J. R.
The early development of the lipid-rich core and other features of atherosclerotic fibrous plaques has been elucidated by examining discrete, small regions of raised intima in human aorta, which often bear a resemblance to both fatty streaks and fibrous plaques. Approximately one-fourth of small raised lesions (less than 16 sq mm of surface area) contained little or no stainable lipid, while three-fourths had a characteristic appearance, which included a superficial layer of foam cells, a core of noncrystalline and/or crystalline lipid, and a developed or developing collagenous cap. Total intimal volumes of the lipid-containing lesions, termed "fibrolipid lesions," ranged from 3 to 43 microliters, with the majority less than 16 microliters. Core lipid in the smallest lesions was located in the musculoelastic layer of the intima. In larger lesions the core extended luminally into the elastic hyperplastic layer, and cholesterol crystals were found more frequently. Total cholesterol concentration in fibrolipid lesions was similar to that in fatty streaks; however, the ratio of unesterified to total cholesterol was relatively high, similar to that found in fibrous plaques. It is concluded that 1) the formation of a lipid-rich core and cholesterol crystallization are early events in the development of many raised lesions; 2) the consistent association between the superficial layer of foam cells and the deep-lying lipid-rich core raises the possibility of an influence, possibly indirect, of foam-cell lipid metabolism on core formation; and 3) the fibrolipid lesion may represent one stage in a potential transitional morphologic sequence between fatty streak and fibrous plaque. Images Figure 2 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 PMID:4025509
Boor, P. J.; Ferrans, V. J.
The late myocardial and vascular ultrastructural changes in rat hearts following consumption of the cardiovascular toxin allylamine were studied. Rats were given 0.1% allylamine HCl in drinking water for 10-104 days. From 10 to 21 days, there was organization of acute myocardial necrosis by macrophages and scattered polymorphonuclear leukocytes with prominent interstitial-cell proliferation. Alterations at 21-104 days included extensive scarring with formation of dense mature collagen with scattered fibroblasts present, grossly evident left-ventricular aneurysm, and gross and microscopic changes similar to those observed in the secondary form of endocardial fibroelastosis. Areas of scar contained highly cellular foci of smooth-muscle cells, myofibroblasts, and abundant extracellular elastin. Cardiac myocytes frequently showed markedly disorganized myofilaments, bizarrely distorted mitochondria with condensed cristae, and other severe degenerative changes. Small vessels within and adjacent to scar showed proliferation of intimal smooth-muscle cells. Endothelial lesions or recent or organized thrombi were not seen. Focal endocardial metaplasia, consisting of both chondroid and osseous tissue, was found in areas of transmural scarring, or ventricular aneurysm. Chondrocytes had the overall nuclear and cellular morphology, abundant rough endoplasmic reticulum, and surrounding lacunae typical of mature fibrocartilage. In some areas, the collagen matrix was undergoing calcification with the typical cross-banded pattern of calcifying connective tissue. Osteocytes were located in a densely calcified bone matrix and displayed characteristic cellular extensions into surrounding canaliculi. These findings indicate a severe myocardial, small-vessel, and endocardial injury during the course of chronic allylamine intoxication. Images Figure 13 Figure 14 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 15 Figure
Castleman, W. L.; Dungworth, D. L.; Schwartz, L. W.; Tyler, W. S.
The pathogenesis of acute respiratory bronchiolitis was examined in rhesus monkeys exposed to 0.8 ppm ozone fpr 4--50 hours. Epithelial injury and renewal was qualitatively and quantitatively characterized by correlated techniques of scanning and transmission electron microscopy as well as by light-microscopic autoradiography following labeling with tritiated thymidine. Extensive degeneration and necrosis of Type 1 epithelial cells occurred on the respiratory bronchiolar wall during the initial 4--12 hours of exposure. Increased numbers of labeled epithelial cells were present in this region after 18 hours of exposure, and the highest labeling index (18% was measured after 50 hours of exposure. Most (67--80%) of the labeled cells and all the mitotic epithelial cells (22) observed ultrastructurally were cuboidal bronchiolar epithelial cells. Of the labeled epithelial cells, 20--33% were Type 2 epithelial cells. After 50 hours of exposure the respiratory bronchiolar epithelium was hyperplastic. The predominant inflammatory cell in respiratory bronchiolar exudate was the alveolar macrophage. Monkeys that were exposed for 50 hours and allowed to recover in unozonized air for 7 days had incomplete resolution of respiratory bronchiolar epithelial hyperplasia. The results indicate that Type 1 epithelial cells lining respiratory bronchioles are the cell type most sensitive to injury and that both cuboidal bronchiolar epithelial cells and Type 2 epithelial cells function as stem cells in epithelial renewal. Images Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 23 Figure 24 Figure 25 Figure 9 Figure 10 Figure 26 Figure 27 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:6767409
Lipkin, L E
The phenomenon of fiber-induced cytotoxicity to P388D1 macrophagelike cells has been demonstrated to parallel (thus far without exception) the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats. This startling parallel in both cases seems to be essentially independent of the chemical nature of the fiber and correlates best with the presence of fibers greater than 8 micrometers in length and fibers with diameters in the range 0.5 to 1.0 micrometer (Stanton Hypothesis). In both systems evidence has been produced which cast strong doubts on any role played by absorbed (or adherent) impurities. The existence of multiple physical forms of the same chemical moiety (aluminum oxide, dihydroxy-sodium aluminum carbonate, borosilicate glass, etc.,) provides additional test material for the chemical independence corollary. The similar, cytotoxic or sarcomatogenous behavior of chemically different materials (e.g. amosite, chrysotile, aluminum oxide) exhibits the necessary converse argument. As long as the fiber size-shape dependency effect was limited to whole animal phenomena, such as tumor induction, one could make implicitly what were essentially statistical or probabilistic inferences involving transport and/or distribution of fibers to account for the physical effect. The demonstration of strict parallelism at the cellular level in vitro suggests the possibility that in the case of durable fiber toxicology we are dealing with a form of cell-solid interaction in which physical properties for which we have as yet no known receptors play a prominent role. Images FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. FIGURE 13. PMID:7389690
inventions to declare during the performance of this grant. Peter Nilsson, Björn Samel AAC Microtec AB Dag Hammarskjolds Vag 54 SE-751 83 Uppsala...10 Figure 3: Contact angle measurement for evaluation of wettability ..........................................................12 Figure 4...from the side. Figure 3 and Figure 4 show the contact angle measurement for evaluation of wettability and examples of different wetting cases. Figure
SPONSORING /MONITORING AGENCY NAME(S) AND ADDRESS(ES) N/A 10. SPONSORING/MONITORING AGENCY REPORT NUMBER 11 . SUPPLEMENTARY NOTES The views...panel) and eastern (right panel) Altantic Ocean. Adopted from You (2002).. 11 Figure 7. Same as Figure 4, but for Indian Ocean..........12 Figure 8...well developed field of two dimensional diffusive plumes after t= 50 . Note the well defined horizontal layers in the right figure after t=500. The
4 EMT-2 Laser Spot Energy Measurement 5-11 Figure 5-5 PILASTER FRCT Target Construction 5-12 Figure 5-6 PILASTER FXDT Target Layout 5-13 Figure 5... energy has been optically collected, obstacle detection/classification is performed through an analog detection of the echoes and two successive analysis ... analysis (i.e., geometry, energy distribution, time analysis ), for the maximum number of pulses (spots) in a sequence, for the PHOENIX NIR camera; and
Etiologic Agent of ARD 2. Serological ID. MENINGOCOCCUS : 1. Carrier Rates 2. Disease Surveillance (Contd. see reverse) 20. ASTNACT (’"Cimtbue - reverse N...Hospitalizations at BCT Posts - FY , ARD rate /lOO/week ................................ 5 Figure 2. ARD Hospitalizations with Adenovirus Infections vs...11 Figure 8. ARD Hospitalization Rate /lOO/Month, FY /76 & , Fort Sill ........................................ 12 Figure 9. ARD Hospitalizations
VO2 max ) Test ......................................... 7 Figure 3 - VO2 Max results for Male, Female and All Subjects. * p...0.001 between Male and Female VO2 ’s. ............................................................. 11 Figure 4 - VO2 Max vs Predicted VO2 Max at 850...and 7,200 Feet ................. 12 Figure 5 - Actual VO2 Max vs Predicted VO2 Max at ALT (7,200 Feet) ....... 13 Figure 6 - VO2 Max vs
window size of 10. Figure 5-7 shows the ROC curve of the “EWMA vector” classifier for the λ value of 0.04 based on the CHAID algorithm in comparison ...k(i), from the training data using the event intensity method ...11 Figure 1-2. The observations of the event intensity, k(i), from the testing data using the event intensity method
utilizing the Alamouti- based space-time block coding (STBC) technique. All cases are based on the IEEE 802.16-2004 standard with OFDM using different...Oscillator Based OFDM Transmitter, after ..................................................8 Figure 5. IDFT Based OFDM Transmitter, after [1...10 Figure 7. OFDM Signal Spectrum with Ten Sub-Carriers, after ...............................11 Figure 8. DFT Based OFDM Receiver
Bessolo, Rodney J.; Vincent, William R.
The differential diagnosis of congenital heart disease which presents cyanosis or respiratory distress, or both, in the first two weeks of life, is difficult. Close correlation of clinical features, electrocardiogram and chest roentgenogram is most helpful. The diagnosis of congenital heart disease should lead to immediate cardiac catheterization, angiocardiography and appropriate therapy. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12. PMID:5773478
Cortinovis, C.; Klimek, F.; Nogueira, E.
application of some carcinogens at high doses, they are not obligatory precursors of hepatocellular tumors. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 Figure 23 Figure 24 PMID:1951631
McKeever, P. E.; Smith, B. H.; Taren, J. A.; Wahl, R. L.; Kornblith, P. L.; Chronwall, B. M.
cell types may increase our understanding of the mechanism of antigenic changes in gliomas and may provide clues to improved therapeutic approaches. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:3555104
Meyers, S M
; this included the one dizygotic pair which was discordant for basal laminar drusen. The data of this study strongly suggest a genetic predisposition to AMD. Images FIGURE 1 FIGURE 1 (cont.) FIGURE 2 FIGURE 2 (cont.) FIGURE 2 (cont.) FIGURE 3 FIGURE 3 (cont.) FIGURE 3 (cont.) FIGURE 3 (cont.) FIGURE 4 FIGURE 4 (cont.) FIGURE 5 FIGURE 5 (cont.) FIGURE 5 (cont.) FIGURE 6 FIGURE 6 (cont.) FIGURE 7 FIGURE 7 (cont.) FIGURE 8 FIGURE 8 (cont.) FIGURE 9 FIGURE 9 (cont.) FIGURE 9 (cont.) FIGURE 10 FIGURE 10 (cont.) FIGURE 11 FIGURE 11 (cont.) FIGURE 11 (cont.) FIGURE 12 FIGURE 12 (cont.) FIGURE 12 (cont.) PMID:7886884
Alexander, N. J.; Smythe, N. L.; Jokinen, M. P.
immune cells. Images Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:3565532
Severe microvascular injury induced by lysosomal releasates of human polymorphonuclear leukocytes. Increase in vasopermeability, hemorrhage, and microthrombosis due to degradation of subendothelial and perivascular matrices.
Movat, H. Z.; Wasi, S.
lesions were usually walled off by platelet aggregates and fibrin. At times microthrombi occluded an entire vessel. These changes were interpreted as hemostasis. The mild accumulation of PMNs at the site of injury did not contribute significantly to the microvascular injury. The findings indicate that the unique changes in the microcirculation, not described before, may occur quite frequently, when the microvascular injury is elicited primarily by release of lysosomal constituents by phagocytic or nonphagocytic stimuli. One can conclude that the hallmark of this type of injury is disappearance of basement membrane followed secondarily by disintegration of the vascular wall, followed in turn by hemo Images Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 PMID:3907363
Cuénoud, H. F.; Joris, I.; Majno, G.
of right-sided failure; it can be correlated with the electrocardiographic abnormalities found in the comparable human condition. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 16 Figure 17 Figure 5 Figure 6 Figure 7 Figure 18 Figure 19 Figure 20 Figure 8 Figure 21 Figure 22 Figure 9 Figure 23 Figure 10 Figure 24 Figure 11 Figure 25 Figure 26 Figure 12 Figure 27 Figure 28 Figure 13 Figure 14 Figure 15 PMID:677269
in such future studies on massive suprachoroidal hemorrhage. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32 FIGURE 33 FIGURE 34 FIGURE 35 FIGURE 36 FIGURE 37 FIGURE 38 FIGURE 39 FIGURE 40 FIGURE 41 FIGURE 42 FIGURE 43 FIGURE 44 FIGURE 45 FIGURE 46 FIGURE 47 FIGURE 48 FIGURE 49 FIGURE 51 figure 52 FIGURE 53 FIGURE 54 FIGURE 55 FIGURE 56 FIGURE 57 FIGURE 58 FIGURE 59 FIGURE 60 FIGURE 61 FIGURE 62 FIGURE 63 FIGURE 64 FIGURE 65 FIGURE 66 FIGURE 67 FIGURE 68 FIGURE 69 PMID:8140705
Zaki, Sherif R.; Greer, Patricia w.; Coffield, Lisa M.; Goldsmith, Cynthia S.; Nolte, Kurt B.; Foucar, Kathy; Feddersen, Richard M.; Zumwalt, Ross E.; Miller, Gayle L.; Khan, Ali S.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.; Mahy, Brian W.J.; Peters, Clarence J.
a newly recognized, often fatal disease, with a spectrum of microscopic morphological changes, which may be an important cause of severe and fatal illness presenting as adult respiratory distress syndrome. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 12Figure 13Figure 14Figure 15 PMID:7887439
Knox, D L; Kerrison, J B; Green, W R
FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 A FIGURE 24 B FIGURE 24 C FIGURE 24 D FIGURE 24 E FIGURE 24 F FIGURE 25 A FIGURE 25 B FIGURE 25 C FIGURE 25 D FIGURE 25 E FIGURE 25 F FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 PMID:11190024
Wilson, D. W.; Plopper, C. G.; Dungworth, D. L.
important participants in the repair of chemically injured airway epithelium; stratification and increased amounts of cytoplasmic filament bundles and desmosomal attachments, rather than being evidence of squamous metaplasia or dysplastic change, might be stereotypic responses of airway epithelium to injury; and the ciliated cell population becomes less susceptible to ozone-induced necrosis with continuing exposure. Images Figure 21 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 26 Figure 27 PMID:6540523
Buja, L. M.; Kovanen, P. T.; Bilheimer, D. W.
2 Figure 3 Figure 4 Figure 5 Figure 10 Figure 11 Figure 25 Figure 26 Figure 27 Figure 28 Figure 29 Figure 8 Figure 9 Figure 24 Figure 20 Figure 21 Figure 12 Figure 13 Figure 14 Figure 15 Figure 22 Figure 23 PMID:118674
Ciocca, D. R.; Puy, L. A.; Stati, A. O.
The follicular structures present in the human pituitary gland were studied, at the light-microscopic level, using histochemical and immunocytochemical techniques. The antisera applied in the peroxidase-antiperoxidase procedure were anti-hFSH beta, anti-hLH beta, anti-hPRL, anti-hGH, anti-hTSH beta, anti-hLPH beta, anti-pACTH, and anti-hACTH. In the 10 normal pituitaries examined, follicles were always found in the three areas of the adenohypophysis. The wall of the pars distalis follicles showed the seven immunoreactive cell types studied, while follicle-stimulating hormone (FSH) and luteinizing hormone (LH) cells were the only ones present in the wall of the pars tuberalis follicles. Most of the cell types studied were also present in the wall of the intermediate area follicles, but these follicles had characteristics not found in the other two areas. They were very large, with frequent interconnections forming a three-dimensional network of anastomotic cavities, and the colloid had different histochemical affinity. None of the hormones studied could be detected by immunocytochemistry within the follicular colloid. Three of the ten pituitary adenomas examined showed numerous follicular structures. Some of the follicles in the adenomatous pituitaries were similar to those found in the normal adenohypophysis, but there were also follicles filled with only traces of colloid and numerous blood cells in the cavity, and follicles filled with neoformed connective tissue. In one of these cases, FSH/LH immunoreactive adenoma cells were seen in the wall of the follicles. The results obtained suggest that the finding of pituitary adenomas with follicular structures is not uncommon and that the follicles originate from the tumor cells. In addition, the follicles seem to have several functional stages, explaining the finding of different types of follicular formation. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11
White, J. G.; Rao, G. H.
in combination with taxol, inhibited the cold-induced shape change but not dilation of the open canalicular system. Rewarming eliminated open canalicular system dilation and restored lentiform appearance. The results indicate that microtubule coils are the major structural elements responsible for disc shape and its restoration after submaximal stimulation or rewarming of chilled platelets. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 Figure 23 Figure 24 Figure 25 Figure 26 Figure 27 Figure 28 Figure 29 Figure 30 PMID:9466587
Runge, P E
PURPOSE: Eduard Jaeger's original Test-Types were carefully evaluated: (1) to determine whether Jaeger had maintained a consistent standard, (2) to establish the correct Snellen equivalent for Jaeger's Test-Types, (3) to answer the question of why and how the standard was lost, and (4) to compare the visual angle of optotypes to lines of continuous text. METHODS: All original Viennese editions of Jaeger's Test-Types, as well as first generation United Kingdom (UK) and United States (US) versions, were evaluated. Data were collected objectively using a microruler with a 20X loupe and subjectively using a laser distance-measuring device. The data were analyzed using Microsoft Excel. All previous measurements of Jaeger's Test-Types, objective and subjective, collected over the past 133 years were compared to the current data and to each other. RESULTS: The correct Snellen equivalent of Jaeger's Test-Types was determined. The visual angle created from the measurement of the height of lowercase letters, without ascenders or descenders, provides an accurate method of assigning a visual angle of a line of continuous text. Comparing the typefaces used in printing first generation UK and US versions of Jaeger's Test-Types to the Viennese editions provided an explanation for the absence of a consistent standard for Jaeger's Test-Types today. CONCLUSIONS: All 10 versions of Jaeger's original Test-Types are virtually identical and established a gold standard for reading vision tests. Jaeger's standard was lost when his Test-Types were first printed in the UK and the US using local typefaces. The Jaeger standard has been re-established. Visual angles determined using continuous text are comparable to those obtained by using optotypes. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7C FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19A FIGURE 19B p409-a FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE
Rehm, S.; Lijinsky, W.; Singh, G.; Katyal, S. L.
neoplastic lesions. N-nitroso-methyl-bis-chloroethylurea- and NTCU-induced mouse bronchiolar cell alterations could be an interesting new model to study mechanisms of bronchiolar cell differentiation and tumor formation. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 PMID:1651059
Stills, H. F.; Bullock, B. C.; Clarkson, T. B.
, attached to, and penetrating into the intima of the coronary lesions. No correlation was seen between the development of glomerulonephritis and either aortic or coronary artery atherosclerosis. Images Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 PMID:6227252
10 Figure 7 OFDMA Frequency Domain and Subchannels (From Ref. )......................12 Figure 8 Multipath Fading Environment (From Ref...various subcarriers into subchannels for both the UL and DL to support multiple users. The data is divided on the subchannels so that OFDMA symbols...are mapped in the time domain via TDMA but also must be mapped to the specific subchannel on which each symbol will be transmitted, thereby
12 Figure 9. Location of 3.39 µm He-Ne Laser Transmission...transmission measurements were made at two locations with a 3.39 µm He-Ne laser [Figure 9] and an infrared diode to determine the proper timing of the...the main combustor [Figure 10]. Figure 9. Location of 3.39 µm He-Ne Laser Transmission Figure 10. Transducer Locations 13 Various other
Farber, Eugene M.
Prevalence of psoriasis in Caucasians is estimated as 2 to 3 percent. Sound epidemiologic studies on a worldwide basis are needed to secure accurate prevalence rates for comparative purposes. Utilizing Stanford's psoriasis life histories records, the genetics of psoriasis has been explored by various means: statistical census data, pedigree analysis, and twin studies. This research suggests a multifactorial pattern of inheritance for psoriasis, implying that both genetic and environmental components are responsible for the manifestation of the disease. At present it is not possible to point to any single causative factor. Some of the suggested areas for research include study of uninvolved skin, growth control in the psoriatic lesion, viral causes, immunological aspects, and lipid metabolism. ImagesFigure 1.Figure 2.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 9.Figure 10.Figure 11.Figure 11.Figure 12. PMID:5578103
Cram, David L.
Four life-threatening dermatoses—Stevens-Johnson syndrome, toxic epidermal necrolysis, Kaposi's varicelliform eruption and purpura fulminans—are unique in their abrupt onset and rapid progress to death, but prompt diagnosis and proper therapy can often cure the condition or prevent undesirable sequelae. Since two of the four conditions can follow the use of a variety of drugs and all may be secondary to an infectious agent, any physician may encounter them in practice and should be aware of their seriousness. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12. PMID:4701711
Stager, D R
patients who have undergone anterior transposition surgery, the NFVB served as the ancillary origin of the IO. CONCLUSIONS: The name of the neurovascular bundle should be changed to the NFVB, since it has a prominent fibrocollagenous capsule and it is encased in fibrous tissue bands anteriorly. The NFVB has a linear course in the orbit from the apex to the IO muscle and is relatively stiff. The associated fibrous band extends posteriorly from the IO muscle capsule, encasing the nerve anteriorly and attaching 3 to 7 mm posteriorly into the capsule of the IR. The NFVB binds the mid posterior portion of the IO posteriorly. Its ligamentous qualities enable the NFVB to function as an ancillary origin for the IO. Images FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 A FIGURE 13 B FIGURE 13 C PMID:8981719
Russo, I H; Russo, J
in cancer initiation. Comparative studies with the development of the human breast and the pathogenesis of breast cancer have contributed to validate rodent-to-human extrapolations. However, it has not been definitively established what type of information is necessary for human risk assessment, whether currently toxicity testing methodologies are sufficient for fulfilling those needs, or whether treatment-induced tumorigenic responses in rodents are predictive of potential human risk. An alternative to the traditional bioassays are mechanism-based toxicology and molecular and cellular approaches, combined with comparative in vitro systems. These approaches might allow the rapid screen of chemicals for setting priorities for further studies to determine the dose-response relationship for chemical effects at low doses, to assess effects other than mutagenesis and/or tumorigenesis, or to establish qualitative and quantitative relationships of biomarkers to toxic effects. Until there is enough information on the predictive value of mechanism-based toxicology for risk assessment, this approach should be used in conjunction with and validated by the traditional in vivo long-term bioassays. Images Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. A Figure 7. B Figure 8. A Figure 8. B Figure 9. Figure 10. Figure 11. Figure 12. Figure 13. Figure 14. Figure 15. Figure 16. Figure 17. Figure 18. Figure 19. Figure 20. Figure 21. Figure 22. Figure 23. Figure 24. Figure 25. Figure 26. PMID:8899375
Bullock, J D; Warwar, R E; Green, W R
-bank eyes and the theoretical analyses of this entity show that the pressure required to produce such an injury is much more easily obtained with a 3- or 5-mL syringe than with a syringe 10 mL or larger. CONCLUSIONS: Explosion of an eyeball during the injection of anesthesia for ocular surgery is a devastating injury that may go unrecognized. The probability of an ocular explosion can be minimized by careful use of a syringe 10 mL or larger with a blunt needle, by discontinuing the injection if resistance is met, and by inspecting the globe prior to ocular massage or placement of a Honan balloon. When ocular explosion occurs, immediate referral to and intervention by a vitreoretinal surgeon is optimal. Practicing ophthalmologists should be aware of this blinding but preventable complication of ocular surgery. Images FIGURE 1 Figure 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 PMID:10360292
. ( Images FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURES 24 FIGURES 25 FIGURES 26 FIGURES 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 PMID:10360310
Jakobiec, F A
melanocytes and exhibited more haphazard arrangements of the melanofilaments, which were only partially melaninized. Mitochondria were more numerous than in dendritic melanocytes, and monoribosomes predominated over polyribosomes. Cytoplasmic filaments were inconspicuous. Cells in the immediate subepithelial connective tissue zone had features identical to those of the cells within the junctional nests. Smaller, lymphocytoid cells with less numerous and more rudimentary melanosomes were found in the middle and deeper portions of the lesions.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 21 FIGURE 22 FIGURE 42 FIGURE 67 FIGURE 1 FIGURE 62 FIGURE 26 FIGURE 29 FIGURE 37 FIGURE 11 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 27 FIGURE 28 FIGURE 30 FIGURE 31 FIGURE 32 FIGURE 33 FIGURE 34 FIGURE 35 FIGURE 36 FIGURE 38 FIGURE 39 FIGURE 40 FIGURE 41 FIGURE 43 FIGURE 44 FIGURE 45 FIGURE 46 FIGURE 47 FIGURE 48 FIGURE 49 FIGURE 50 FIGURE 51 FIGURE 52 FIGURE 53 FIGURE 54 FIGURE 55 FIGURE 56 FIGURE 57 FIGURE 58 FIGURE 59 FIGURE 60 FIGURE 61 FIGURE 63 FIGURE 64 FIGURE 65 FIGURE 66 FIGURE 68 FIGURE 69 FIGURE 70 FIGURE 71 FIGURE 72 FIGURE 73 FIGURE 74 FIGURE 75 FIGURE 76 FIGURE 77 FIGURE 78 FIGURE 79 FIGURE 80 FIGURE 81 FIGURE 82 FIGURE 83 FIGURE 84 FIGURE 85 FIGURE 86 FIGURE 87 FIGURE 88 FIGURE 89 PMID:6398936
Van Vleet, J. F.; Ferrans, V. J.
seen less frequently; and, in contrast to man, coronary artery disease and myocardial ischemia are rather infrequent in animals. The present review shows clearly that the spectrum of myocardial diseases in animals is enlarging and that many newly recognized diseases are emerging and assuming considerable importance. For example, various heritable cardiomyopathies have recently been described in the KK mouse, cattle, and rats. Increasingly recognized myocardial diseases include cardiomyopathies in cats, dogs, and birds; anthracycline cardiotoxicity; furazolidone cardiotoxicity; ionophore cardiotoxicity; myocardial damage associated with central nervous system injuries; myocardial hypertrophy in Images Figure 1 Figure 2 Figure 45 Figure 46 Figure 47 Figure 48 Figure 61 Figure 62 Figure 63 Figure 64 Figure 79 Figure 75 Figure 76 Figure 77 Figure 78 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 Figure 23 Figure 24 Figure 25 Figure 26 Figure 27 Figure 28 Figure 29 & 30 Figure 31 Figure 32 Figure 33 Figure 34 Figure 35 Figure 36 Figure 37 Figure 38 Figure 39 Figure 40 Figure 41 Figure 42 Figure 43 Figure 44 Figure 49 Figure 50 Figure 51 Figure 52 Figure 53 Figure 54 Figure 55 Figure 56 Figure 57 Figure 58 Figure 59 Figure 60 Figure 65 Figure 66 Figure 67 Figure 68 Figure 69 Figure 70 Figure 71 & 72 Figure 73 & 74 PMID:3524254
Ludwig, I H
limitation of versions, less separation of the tendons from sclera, and thicker appearance of the scar segments. The use of nonabsorbable sutures in the repair procedure reduced the recurrence rate. Histologic examination of the clinical stretched scar specimens showed dense connective tissue that was less well organized compared with normal tendon. In the tissue culture studies, cells cultured from the stretched scar specimens grew rapidly and were irregularly shaped. A high-molecular-weight protein was identified in the culture medium. By contrast, cells cultured from normal tendon (controls) grew more slowly and regularly, stopped growing at 4 days, and produced less total protein than cultured stretched scar specimens. In the animal model studies, the collagenase-treated sites showed elongated scars with increased collagen between the muscle and the sclera, as well as increased collagen creep rates, compared with the saline-treated controls. The use of nonabsorbable sutures in collagenase-treated animal model surgery sites was associated with shorter, thicker scars compared with similar sites sutured with absorbable sutures. CONCLUSIONS: A lengthened or stretched, remodeled scar between an operated muscle tendon and sclera is a common occurrence and is a factor contributing to the variability of outcome after strabismus repair, even years later. This abnormality may be revealed by careful exploration of previously operated muscles. Definitive repair requires firm reattachment of tendon to sclera with nonabsorbable suture support. Images FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32 FIGURE 33 FIGURE 34 FIGURE 35 FIGURE 36 FIGURE 37 FIGURE 38 FIGURE 39 FIGURE 40 FIGURE 41 FIGURE 42 FIGURE 43 FIGURE 44 FIGURE 45 FIGURE 46 FIGURE 52
Blankenship, G W
than the pretreatment acuities with fewer cases having larger losses of vision in the krypton treated group. Loss of peripheral visual field was equal with the two types of treatment having a minimal decrease with the IV-4e isopter, but substantial loss with the I-4e isopter. Additional vitreous hemorrhage rarely occurred in either group, but was slightly more frequent in those treated with krypton. Complete regression was accomplished in most eyes with pretreatment disc and/or NVE in both groups, but persistence of neovascularization was more frequent in those treated with krypton. Overall, the wavelength used seemingly had little effect on the result.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 PMID:2438841
Keating, Joseph C
Chiropractic education in the northwestern United States has its origins in the Marsh School & Cure in 1904. Most of the early schools were located in Portland, Oregon, including the D.D. Palmer College of Chiropractic (1908-1910), and several of these had merged by 1912 or 1913 to form the Pacific Chiropractic College, forerunner of today's Western States College. The latter was organized as a non-profit institution during the Great Depression, and struggled not only to survive but to create a higher standard. The early broad-scope of chiropractic training in the state probably encouraged the liberal scope of practice enjoyed in Oregon to this day. ImagesFigure 2Figure 3Figure 4Figure 6Figure 7Figure 8Figure 9Figure 11Figure 12Figure 13Figure 14Figure 15Figure 16Figure 18Figure 19Figure 20Figure 21Figure 22Figure 24
Pattengale, P. K.; Taylor, C. R.
The present review focuses on the mouse as an experimental immunopathologic model for human non-Hodgkin's lymphomas and related leukemias. Immunomorphologic evidence is presented that clearly demonstrates that B- and T-cell subtypes of mouse (murine) lymphoma/leukemia closely resemble and are analogous to B- and T-cell subtypes of human lymphoma/leukemia as defined by recently proposed immunomorphologic classifications. Further evidence is presented that favors the hypothesis that certain types of murine and human B-cell lymphoma develop out of prodromal, prelymphomatous states, which exhibit antecedent morphologic and immunologic abnormalities. The many experimental advantages of the murine systems are stressed, as well as the concept that the presently defined immunomorphologic approach should be effectively combined with molecular and cytogenetic parameters. Images Table 6 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 10 Table 9 Figure 11 Figure 12 Figure 13 PMID:6605691
Biglan, A W
Patients with spina bifida have multiple ophthalmologic problems, many of which are preventable. Most of the problems are related to the hydrocephalus, which is caused by the coexisting Arnold-Chiari malformation. When patients are treated for hydrocephalus, and comprehensive eye care is available, 94% of the patients will have 6/12 visual acuity or better. Strabismus is common but it responds well to medical and surgical treatment. Children with spina bifida should have frequent examinations by an ophthalmologist who is familiar with the diagnosis and management of the defects recorded in this study. Images FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 PMID:2095031
Alvi, Aijaz; Janecka, Ivo P.; Kapadia, Silloo; Johnson, Bruce L.; McVay, William
The length of the optic nerves is a reflection of normal postnatal cranio-orbital development. Unilateral elongation of an optic nerve has been observed in two patients with orbital and skull base neoplasms. In the first case as compared to the patient's opposite, normal optic nerve, an elongated length of the involved optic nerve of 45 mm was present. The involved optic nerve in the second patient was 10 mm longer than the normal opposite optic nerve. The visual and extraocular function was preserved in the second patient. The first patient had only light perception in the affected eye. In this paper, the embryology, anatomy, and physiology of the optic nerve and its mechanisms of stretch and repair are discussed. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 13 PMID:17170975
Berry, J. P.; Henoc, P.; Galle, P.; Pariente, R.
The results of a study of 90 patients are presented. Intrapulmonary mineral deposits were characterized by electron diffraction and electron probe microanalysis. Using this method, pneumoconioses may be distinguidhed from other pneumopathies. In cases of pneumoconiosis, there exists a specific relationship between the etiology of the dust exposure and the crystallographic characteristics of the intrapulmonary deposits. The nature of the deposits may be indicative of a specific type of pneumoconiosis. This method is particularly useful in differentiating between asbestos bodies and ferruginous bodies. The value of the method in general and its importance in the study of pneumoconiosis are discussed. Images Figure 4 Figure 13 Figure 5 Figure 14 Figure 6 Figure 15 Figure 7 Figure 16 Figure 8 Figure 17 Figure 1 Figure 9 Figure 10 Figure 2 Figure 11 Figure 3 Figure 12 PMID:937507
Glaeser, Robert M.; Thomas, Gareth
Three methods by which electron diffraction may be applied to problems in electron microscopy are discussed from a fundamental point of view, and experimental applications with biological specimens are demonstrated for each case. It is shown that wide-angle electron diffraction provides valuable information for evaluating specimen damage that can occur either during specimen preparation or while in the electron beam. Dark-field electron microscopy can be used both to enhance the image contrast and to provide highly restricted and therefore highly specific information about the object. Low-angle electron diffraction provides quantitative information about the object structure in the range from 20 A to ∼ 1000 A. Lowangle electron diffraction also demonstrates the important role of Fourier contrast with biological specimens, which are usually characterized by structural features with dimensions of 20 A or larger. ImagesFigure 1Figure 2Figure 5Figure 6Figure 7Figure 8Figure 9Figure 10Figure 11Figure 13 PMID:4896898
Dummett, C. O.
Brief highlights of the careers of 13 Afro-American dentists have been presented. Their professional lives demonstrated both a commitment to the advancement of dentistry and a dedication to the betterment of humanity. Of the 13, three spent their professional lives exclusively in dental education, research, and public health. The remaining 10 were dental clinicians who served patients with competence, care, and concern. Additionally, they contributed to dentistry's image and progress by improving medicodental relations, pioneering in university dental education, engaging in philanthropy, qualifying for dental specialties, exerting leadership in dental professional organizations, integrating dentistry in hospital care, solving community health problems, and participating in all aspects of dental journalism. A sizable portion of their energies was expended in enhancing the quality of life in their communities and the nation. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:2651678
Zagzag, D.; Brem, S.; Robert, F.
A model for the study of tumor angiogenesis within the rabbit brain is presented. Implantation of the VX2 carcinoma provides a reproducible tumor accompanied by angiogenesis. The authors report the sequential growth, histology, tumor neovascularization, and vascular permeability of this tumor following its intracerebral implantation. Tumor angiogenesis correlates with the rapid and logarithmic intracerebral tumor growth. The proliferation of blood vessels in the tumor and the organization of tumor cells around tumor vessels are described. Breakdown of the blood-brain barrier (detected by Evans blue leakage) starts in the early stages of tumor development and becomes prominent as the tumor vasculature and size increase. This model is useful for experimental studies of angiogenesis. Images Figure 2 Figure 3 Figure 6 Figure 4 Figure 5 Figure 7 Figure 8 Figure 10 Figure 12 Figure 13 Figure 15 PMID:2451889
The nephrotic syndrome, glomerulonephritis, disseminated lupus erythematosus and the Fanconi syndrome show characteristic changes with electron microscopy. Experimental studies of animals were carried out to determine the significance of such changes by observing reactions that occur under carefully controlled conditions. A lesion with collagen deposition that was found in the centrolobular region of glomeruli sheds new light on the function of this region. This evidence must be considered in developing an understanding of how the production of urine is controlled. Fluid-filled compartments and various bodies associated with the ultrastructure of tubule cells can be produced under conditions which suggest that these structures play a role in tubular resorption. ImagesFigure 1, 2.Figure 3.Figure 4, 5.Figure 6, 7.Figure 8, 9.Figure 10.Figure 11, 12.Figure 13, 14.Figure 15, 16.Figure 17. PMID:13759386
8 Figure 4. Stream discharge at Xeriscape garden station (16226200) for July 1 to September 30, 2004 ……………………………………………………………………………… 9 Figure 5...the 3-hour period from 17:00 to 20:00 October 30, 2004 ………………………………………… 10 Figure 6. Stream discharge at Xeriscape garden station (16226200) for...period from 00:00 to 12:00 December 27, 2004 ……………………………………………………………………………… 12 Figure 8. Stream discharge at Xeriscape garden station (16226200) for
Leggett, R W
with data on human subjects exposed to lead under a variety of experimental and natural conditions. Images p598-a Figure 1. Figure 2. Figure 3. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. A Figure 7. B Figure 7. D Figure 7. E Figure 8. Figure 9. Figure 10. Figure 10. Figure 10. Figure 11. Figure 11. Figure 12. p613-a PMID:8143593
Schwab, I R
from any eye is difficult, making confirmation of such work challenging. 7. The results of the rabbit model suggest that allogeneic grafts may restore a nearly normal ocular epithelial surface to certain ocular surface injuries. Images FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32 FIGURE 33 FIGURE 34 FIGURE 35 FIGURE 36 FIGURE 37 FIGURE 38 FIGURE 39 FIGURE 40 FIGURE 41 FIGURE 42 FIGURE 43 FIGURE 44 FIGURE 45 FIGURE 46 FIGURE 47 FIGURE 48 FIGURE 49 FIGURE 50 FIGURE 51 FIGURE 52 FIGURE 53 FIGURE 54 FIGURE 55 FIGURE 56 FIGURE 57 FIGURE 58 PMID:10703147
O'Neill, J F
and may vary from blindness and severe mental retardation to minor retinochoroidal lesions of little consequence. Effective solutions for either the prevention or treatment of congenital toxoplasmosis have not been developed in this country but are under intensive and continuing investigation. Images FIGURE 4 FIGURE 5A FIGURE 5B FIGURE 5C FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15A FIGURE 15B FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20A FIGURE 20B FIGURE 20C FIGURE 20D FIGURE 20E FIGURE 20F FIGURE 20G FIGURE 20H FIGURE 20J FIGURE 20K FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 A FIGURE 24B FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32 PMID:10360309
Klösgen, B; Helfrich, W
Using cryo-transmission electron microscopy, we have obtained abundant and reproducible evidence for a superstructure of dioleoylphosphatidylcholine (DOPC) bilayers. Dispersions of vesicles were prepared by gentle shaking of a 2% suspension of DOPC in water followed in part by extrusion through a porous technical membrane. Sampling and cryofixation took place at various times within 3 weeks after the preparation. From the micrographs we infer that the small fraction of vesicles enclosing one another develop passages (connections) between the bilayers. In contrast, the superstructure is basically a feature of disconnected membranes. Among its modifications are isolated membrane bends or folds and a grainy membrane texture with a minimal grain spacing of 4-6 nm. In the extruded dispersions the passages and the superstructure seem to be formed mostly within the first day. The fraction of smooth and unilamellar vesicles is large at all times and in all dispersions. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 PMID:9414216
Sadler, T W
One of the original principles of teratology states that, "Susceptibility to teratogenesis varies with the developmental stage at the time of exposure to an adverse influence" [Wilson JG. Environment and Birth Defects. New York:Academic Press, 1973]. The time of greatest sensitivity encompasses the period of organ formation during weeks 3-8 following fertilization in human gestation. At this time, stem cell populations for each organ's morphogenesis are established and inductive events for the initiation of differentiation occur. Structural defects of the heart and endocrine system are no exception to this axiom and have their origins during this time frame. Although the function and maturation of these organs may be affected at later stages, structural defects and loss of cell types usually occur during these early phases of development. Thus, to determine critical windows for studying mechanisms of teratogenesis, it is essential to understand the developmental processes that establish these organs. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:10852854
Ukimura, A.; Deguchi, H.; Kitaura, Y.; Fujioka, S.; Hirasawa, M.; Kawamura, K.; Hirai, K.
Group B Coxsackieviruses are a common cause of myocarditis. To detect the viral genome and its localization in the myocardium, we examined C3H/He mice with Coxsackievirus B3 (CVB3) myocarditis on days 5, 8, and 14 after inoculation by the reverse transcriptase polymerase chain reaction and by in situ hybridization. Sense and antisense CVB3 RNA were detected in the myocardium of all mice up to day 14 by reverse transcriptase polymerase chain reaction. Light microscopic in situ hybridization with a cDNA probe for CVB3 showed clusters of positive signals in the areas of myocardial necrosis and cell infiltration. With electron microscopic in situ hybridization, CVB3 RNA was detected in the cytoplasm of cardiocytes, between the myofibrils, near the mitochondria, and in tubular or vesicular structures. Viral RNA was also detected in necrotic debris, in the cytoplasm of macrophages, and in the cytoplasm of interstitial fibroblasts. These findings suggest that CVB3 RNA is replicated in the cytoplasm of cardiocytes, transferred into tubular or vesicular structures, released into the interstitium, and phagocytosed by macrophages. Some positive signals were also detected in the cytoplasm of cardiocytes showing close contact with infiltrating lymphocytes, suggesting that the lymphocytes recognized virus-infected cardiocytes and caused cell-mediated immune cardiocyte damage. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:9176398
Masliah, E.; Terry, R. D.; Alford, M.; DeTeresa, R.; Hansen, L. A.
Quantification of synaptophysinlike immunoreactivity is a valuable method for studying the presynaptic terminals in the normal and damaged nervous system. The present report shows that in the control brain, the predominant pattern of synaptic immunostaining in the neocortex was that of an evenly distributed densely granular immunolabeling of the neuropil, while in the paleocortex and in subcortical areas of the brain most of the presynaptic terminals were distributed along the dendritic arborizations or around the neuronal somata. The immunochemical and the immunohistochemical analysis of the Alzheimer's disease tissue showed that the frontal and parietal cortex presented the most severe and widespread loss, with a 45% loss in synaptophysin immunoreactivity. These areas showed an average 35% loss of large neurons. The visual cortex, hippocampus, entorhinal cortex, nucleus basalis of Meynert, and locus ceruleus displayed some degree of loss, but to a lesser extent. In addition to this loss, the basic patterns of organization of the presynaptic terminals were altered, with the presence of abundant, enlarged synaptophysin-labeled terminals. This study further supports the role of synaptic pathology in Alzheimer's disease. Images Figure 10 Figure 11 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 12 PMID:1899001
Povlishock, J. T.; Rosenblum, W. I.; Sholley, M. M.; Wei, E. P.
Those microvascular endothelial events that parallel the evolution of platelet aggregation were evaluated in a well-controlled animal model. Cat pial microvessels were observed through a cranial window while local platelet aggregation was produced by intravenous injection of sodium fluorescein and simultaneous exposure of the pial vessels to light from a filtered mercury lamp that excited the fluorescein. The vessels were fixed in situ when the in vivo observations of a preselected vessel indicated early, intermediate, or advanced aggregation in that vessel. The preselected vessel was then harvested for ultrastructural study together with adjacent vessels from the illuminated field. These vessels and appropriate controls were compared in semiserial thin sections. The onset of platelet aggregation in both venules and arterioles was accompanied by focal endothelial lucency, vacuole formation, luminal membrane rupture, and swelling of the nuclear envelope. These changes were not found in control material. With intermediate aggregation these changes were more common, while with advanced aggregation these abnormalities occurred together with focal endothelial denudation. Thus, in this model denudation occurred only with advanced aggregation and was not a prerequisite for aggregation. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:6824062
Albini, B.; Nisengard, R. J.; Glurich, I.; Neiders, M. E.; Stinson, M. W.
Intravenous administration of disrupted Streptococcus mutans into rabbits over 23-76 weeks led to severe nephritis involving glomeruli, tubules, and interstitium. Light-microscopic observation of glomeruli documented diffuse endocapillary proliferative glomerulonephritis accompanied often (65%) by epithelial crescents. Electron-microscopic observation revealed humps in glomeruli of 70% of kidney specimens. In the glomeruli of some rabbits, extensive fibrin deposits and sclerosis were evident. Immunofluorescence showed linear, granular, often ribbonlike or patchy immune deposits encompassing, in order of decreasing frequency, C3, IgG, streptococcal antigen, IgA, and IgM. The histopathologic and immunohistologic features of the nephritis seen in rabbits given S mutans thus shows many features of Streptococcus-associated nephritides in man, in particular, the diffuse glomerular nephritis encountered in subacute bacterial endocarditis. Further, analysis of nephritis induced by administration of S mutans may have implications for the evaluation and purification of dental caries vaccines. Images Figure 8 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 9 Figure 10 Figure 11 Figure 12 PMID:3976844
Cham, B. P.; Gerrard, J. M.; Bainton, D. F.
Granulophysin, a protein described in platelet dense granule membranes, has been shown to be similar or identical to CD63, a lysosomal membrane protein. We have previously shown granulophysin to be present in neutrophils using immunofluorescence. We now localize granulophysin to the neutrophil azurophilic granules by fine structural immunocytochemistry. Granulophysin expression on the surface membrane of the neutrophil is increased following stimulation of the cells, demonstrated by flow cytometry and fine structural immunocytochemistry. A similar pattern is shown for an anti-CD63 antibody. Incubation of activated neutrophils with D545, a monoclonal antibody to granulophysin, blocks subsequent binding of anti-CD63 antibodies to the cell surface, and anti-CD63 antibodies prevent subsequent binding of D545 as assessed by flow cytometry and immunoblotting. Our results support the homology of CD63 and granulophysin previously demonstrated in platelets and confirm CD63 as an activation marker in neutrophils and the first azurophilic granule membrane marker of neutrophils. Images Figure 1 Figure 2 Figure 3 Figure 6 Figure 9 Figure 10 Figure 11 Figure 12 PMID:8203473
Wallace, B A
Gramicidin A, a hydrophobic linear polypeptide, forms channels in phospholipid membranes that are specific for monovalent cations. Nuclear Magnetic Resonance (NMR) spectroscopy provided the first direct physical evidence that the channel conformation in membranes is an amino terminal-to-amino terminal helical dimer, and circular dichroism (CD) spectroscopy has shown the sensitivity of its conformation to different environments and the structural consequences of ion binding. The three-dimensional structure of a gramicidin/cesium complex has been determined by x-ray diffraction of single crystals using single wavelength anomalous scattering for phasing. The left-handed double helix in this crystal form corresponds to one of the intermediates in the process of folding and insertion into membranes. Co-crystals of gramicidin and lipid that appear to have gramicidin in their membrane channel conformation have also been formed and are presently under investigation. Hence, we have used a combination of spectroscopic and diffraction techniques to examine the conformation and functionally-related structural features of gramicidin A. Images FIGURE 7 FIGURE 6 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 PMID:2420381
Lakowicz, Joseph R.; Gryczynski, Ignacy; Malak, Henryk; Schrader, Martin; Engelhardt, Peter; Kano, Hiroski; Hell, Stefan W.
We examined the fluorescence spectral properties of the DNA stains DAPI (4′,6-diamidino-2-phenylindole, hydrochloride) and Hoechst 33342 (bis-benzimide, or 2,5′-bi-1H-benzimidazole2′-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)) with two-photon (2hν) and three-photon (3hν) excitation using femtosecond pulses from a Ti:sapphire laser from 830 to 885 nm. The mode of excitation of DAPI bound to DNA changed from two-photon at 830 nm to three-photon at 885 nm. In contrast, Hoechst 33342 displayed only two-photon excitation from 830 to 885 nm. DAPI-DNA displayed the same emission spectra and decay times for 2hν and 3hν excitation. Hoechst 33342-DNA displayed the same intensity decay for excitation at 830 and 885 nm. Both probes displayed higher anisotropies for multiphoton excitation as compared to one-photon excitation with ultraviolet wavelengths, and DAPI-DNA displays a higher anisotropy for 3hν at 885 nm than for 2hν at 830 nm. We used 970-nm excitation of DAPI-stained chromosomes to obtain the first three-dimensional images with three-photon excitation. Three-photon excitation of DAPI-stained chromosomes at 970 nm was demonstrated by the power dependence in the fluorescence microscope. ImagesFIGURE 10FIGURE 11FIGURE 12 PMID:9017187
Eriksson, M A; Härd, T; Nilsson, L
Molecular dynamics simulations have been performed on the glucocorticoid receptor DNA binding domain (GR DBD) in aqueous solution as a dimer in complex with DNA and as a free monomer. In the simulated complex, we find a slightly increased bending of the DNA helix axis compared with the crystal structure in the spacer region of DNA between the two half-sites that are recognized by GR DBD. The bend is mainly caused by an increased number of interactions between DNA and the N-terminal extended region of the sequence specifically bound monomer. The recognition helices of GR DBD are pulled further into the DNA major groove leading to a weakening of the intrahelical hydrogen bonds in the middle of the helices. Many ordered water molecules with long residence times are found at the intermolecular interfaces of the complex. The hydrogen-bonding networks (including water bridges) on either side of the DNA major groove involve residues that are highly conserved within the family of nuclear receptors. Very similar hydrogen-bonding networks are found in the estrogen receptor (ER) DBD in complex with DNA, which suggests that this is a common feature for proper positioning of the recognition helix in ER DBD and GR DBD. Images FIGURE 1 FIGURE 6 FIGURE 8 FIGURE 10 FIGURE 11 FIGURE 14 PMID:7696496
Lovett, D. H.; Johnson, R. J.; Marti, H. P.; Martin, J.; Davies, M.; Couser, W. G.
Secretion of glomerular cell-derived matrix metalloproteinases (MMPs) and their specific inhibitors, TIMP-1,2, may play an important role in the turnover of the glomerular extracellular matrix under basal and pathologic conditions. A 66-68 kd MMP secreted by cultured mesangial cells (MC) with activity against Type IV collagen and gelatin was purified and shown by amino-acid sequence analysis to be identical with a Type IV collagenase/gelatinase secreted by certain transformed tumor cell lines. The expression of the mesangial MMP in vivo was limited within the kidney to a small subset of the intrinsic glomerular mesangial cell population. After induction of acute anti-Thy 1.1 glomerulonephritis, there was a large increment in the number of Type IV collagenase-secreting MC, temporally coincident with the development of mesangial hypercellularity. The expression of the MMP inhibitor protein, TIMP-1, was not changed over this period. Ultrastructural studies localized the mesangial MMP to areas of evolving mesangiolysis and at sites of glomerular basement membrane disruption. Enhanced expression of the mesangial cell-derived Type IV collagenase may contribute to the evolution of glomerular injury in this model of immune complex-mediated glomerulonephritis or may be involved in the extensive matrix remodeling process that accompanies this form of glomerular injury. Images Figure 2 Figure 3 Figure 5 Figure 4 Figure 6 Figure 7 Figure 8 and Figure 9 Figure 10 Figure 11 Figure 12 PMID:1321565
Lane, B P; Miller, S L; Drummond, E J
Fragments of tracheal epithelium alone or in continuity with connective tissues, can be maintained in culture medium and used for short term or long term studies of toxicity of a variety of chemicals. Large numbers of uniform cultures are prepared with the aid of a slicing device or by application of simple method for dissecting sheets of epithelium free from underlying cartilage. The cultures may be placed in an exposure chamber-incubator mounted on a microscope stage and monitored continually for ciliostasis and exfoliation of cells. Morphology is further studied by fixation of selected specimens and preparation for light microscopy and electron microscopy. Synthetic functions are evaluated by autoradiographic measurement of incorporation of radioactive precursors into macromolecules and other dynamic features are indirectly assessed by histochemical and histoenzymatic methods. Short-term studies using these several techniques have shown that ciliostasis does not correlate with cell injury in all instances, and a long-term study has demonstrated dose dependence of a cytotoxic agent when duration of culture viability is measured. The method lends itself to a broad range of investigations in which dose, period of exposure, and role of cofactors must be independently and quantitatively assessed. Images FIGURE 1. FIGURE 2. FIGURE 3. FIGURE 4. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. PMID:1017423
Anders, K. H.; Guerra, W. F.; Tomiyasu, U.; Verity, M. A.; Vinters, H. V.
The central nervous system (CNS) has been examined at autopsy in 89 patients who died of the acquired immune deficiency syndrome (AIDS), including 14 patients who died primarily of neurologic complications of the disease. A total of 66 brains (74%) showed significant pathologic abnormalities, with opportunistic infections including cytomegalovirus (14) and cryptococcal (11) infections, progressive multifocal leukoencephalopathy (6), toxoplasmosis (6), and histoplasma microabscesses (1). Incidental Mycobacterium avium-intracellulare infection was found in 4 cases. Simultaneous CNS infection by more than one microorganism was encountered in 5 patients. Subacute (microglial nodule) encephalitis-related to cytomegalovirus infection or possibly brain infection by the causative agent of AIDS was present in 56 cases. Primary CNS lymphoma was noted in 3 patients. Secondary CNS deposits of lymphoma were found in 1 patient, and another patient had lymphomatoid granulomatosis. Vascular complications were not infrequently seen, and included infarcts secondary to vessel occlusion and disseminated intravascular coagulation in 4 patients and intracranial hemorrhage of variable severity in 13. White matter changes included vacuolar myelopathy (3 cases), central pontine myelinolysis (1 case), and foci of calcified, necrotizing leukoencephalopathy in pontocerebellar fibers of the basis pontis (2 cases). These findings highlight the variety of CNS complications in AIDS, some of which are not associated with clinical manifestations. Nevertheless, characterization of all lesions may be important in understanding the neurologic sequelae of AIDS. Images Figure 9 Figure 10 Figure 6 Figure 7 Figure 8 p540-a Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 11 Figure 12 PMID:2876640
Plenat, F.; Klein-Monhoven, N.; Marie, B.; Vignaud, J. M.; Duprez, A.
Antisense oligonucleotides have the ability to inhibit individual gene expression in the potential treatment of cancer and viral diseases. However, the way parenterally administered oligonucleotides distribute themselves into healthy tissues or tumors is poorly understood. In this study, the cell and tissue distribution of two modified or unmodified phosphodiester pentadeca-beta-oligonucleotides intravenously administered to healthy or tumor-bearing nude mice was assessed by autoradiography as well as by direct fluorescence and immunoenzymatic histological methods. Resistance of oligonucleotides to degradation by nuclease activity was previously studied in vitro. Using these methods we were able to show the following: 1) within minutes, oligonucleotides permeate all cells and tissues with the exceptions of erythrocytes and intervertebral discs; 2) cell and tissue distribution does not depend on the sequence of the given oligonucleotide; 3) concentration of oligonucleotides is higher within the connective tissue cells than in the interstitial matrix; 4) after uptake, oligomers partition throughout all of the cellular compartments, including at the highest intracellular concentrations in the nuclei; 5) oligonucleotides penetrate easily the tumor cell compartments, oligonucleotide diffusion being unimpeded by the extracellular matrix. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:7604874
Sone, S.; Bucana, C.; Hoyer, L. C.; Fidler, I. J.
Treatment of F344 rat alveolar macrophages (AMs) in vitro with cell-free supernatant fluids obtained from concanavalin-A (Con A)-stimulated syngeneic lymphocytes induced extensive fusion. The lymphokine responsible for the fusion of AMs (but not other cells) is here referred to as AM fusion factor (Con-A-MFF). Fusion is dependent on the dose of Con-A-MFF and the population density of AM cultures and occurred 10 hours after Con-A-MFF was added to cultures of normal AMs. Con-A-MFF must interact with AMs for more than 8 hours before full expression of fusion is reached at 24 hours. Using a technique allowing for sequential scanning to transmission electron microscopy analysis of cells, the authors determined the relationship of the morphologic characteristics of the surface and the internal structure of cells fusing to form multinucleate giant cells (MGCs). The process of AM fusion begins with the aggregation of AMs, followed by interdigitation of cell processes. Serial sections of MGCs showed lysosomes associated with remnants of plasma membrane in the cytoplasm. The MGCs contained numerous organelles associated with increased secretory activity of cells. Images Figure 13 Figure 14 Figure 3 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:7234965
Singh, G.; Katyal, S. L.; Torikata, C.
Formalin-fixed paraffin-embedded tumor tissues from North American (N = 12) and Japanese (N = 11) patients with lung carcinomas were stained by the immunoperoxidase method for surfactant-specific apoprotein. Cytoplasmic and focal nuclear staining was seen in three "bronchioloalveolar carcinomas" occurring in Japanese patients. We refer to these three tumors as carcinomas of Type II pneumocytes. These neoplasms formed discrete masses with minimal growth along the alveolar septa at margins of the tumors. Papillary growth with lymphocytic infiltrates in the stalks of the papillary processes was the usual growth pattern. Focal noncaseating granulomas were seen in the stroma of 2 cases, and similar granulomas in the draining lymph nodes were noted in 1. The abundant cytoplasm was foamy, and the nuclei were generally vacuolated with frequent eosinophilic inclusions in the vacuoles. By electron microscopy, osmiophilic lamellar bodies or whorled lamellas were seen in the cytoplasm of the 3 tumors staining for surfactant apoprotein. The nuclei in 2 of the 3 cases contained tubular inclusions; the tubules had a diameter of 60 nm and a 20-nm core. Images Figure 4 Figure 1 Figure 2 Figure 3 Figure 5 Figure 6 Figure 7 and 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:6258440
Malins, D C; McCain, B B; Myers, M S; Brown, D W; Krahn, M M; Roubal, W T; Schiewe, M H; Landahl, J T; Chan, S L
A series of field studies was conducted between 1979 and 1985 in Puget Sound, Washington State, to investigate etiological relationships between prevalences of hepatic neoplasms in bottom-dwelling marine fish species, with emphasis on English sole (Parophrys vetulus), and concentrations of toxic chemicals in sediments and affected fish. Statistically significant (p less than or equal to 0.05) correlations have been found between the prevalences of hepatic neoplasms in English sole and the following parameters: sediment concentrations of aromatic hydrocarbons, and concentrations of the metabolites of aromatic compounds in the bile of affected sole. A significant difference (p less than 0.001) was also found between the relative concentrations of aromatic free radicals in the liver microsomes of English sole with liver lesions compared to sole without liver lesions. Laboratory studies designed to evaluate the etiology of the liver neoplasms in English sole have also yielded evidence that is consistent with the view that high molecular weight aromatic hydrocarbons, e.g., benzo[a]pyrene (BaP), are hepatocarcinogens in English sole. The current status of a series of long-term (up to 18 months) exposures of English sole and rainbow trout (Salmo gairdneri) to selected fractions of Puget Sound sediment extracts, enriched with aromatic hydrocarbons and nitrogen-containing aromatic compounds, and to individual carcinogens (e.g., BaP) is discussed. Images FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. PMID:3297664
Collins, William T.; Capen, Charles C.; Kasza, Louis; Carter, Celester; Dailey, Robert E.
Polychlorinated biphenyls (PCB) produced ultrastructural lesions in thyroid follicular cells and reductions in serum thyroxine levels in rats that were time- and dose-dependent. The acute effects (4 week) of PCB (50 and 500 ppm) consisted of an accumulation of lysosomal bodies and colloid droplets in follicular cells with abnormalities of microvilli on the luminal surface. The chronic administration (12 week) of PCB (50 and 500/250 ppm) resulted in a striking distention of many follicular cells with large lysosomal bodies with strong acid phosphatase activity and colloid droplets, blunt and abnormally branched microvilli, and mitochondrial vacuolation. These ultrastructural alterations in follicular cells were associated with a highly significant reduction in serum thyroxine with both the low and the high dose of PCB. Follicular cells remained responsive to the lowered thyroxine level after feeding PCB for 4 and 12 weeks and underwent moderate compensatory hypertrophy and hyperplasia. Thyroid follicles were smaller than in controls and were lined by more columnar cells that occasionally formed papillary projections into the colloid. Residual ultrastructural alterations persisted for 12 weeks following cessation of feeding the compound, and serum thyroxine levels were significantly lower than in control rats. However, 35 weeks after discontinuing PCB, thyroid follicular cells were similar to those in controls and serum thyroxine levels had returned to normal. The striking ultrastructural lesions in follicular cells produced by feeding PCB to rats appeared to contribute to the lowering of serum thyroxine levels, in combination with the known stimulation of peripheral thyroxine metabolism by these compounds. Certain metabolic alterations produced by PCB intoxication in experimental animals and human beings may be related to an alteration in thyroid function. ImagesFigure 7Figure 8Figure 11Figure 12Figure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 9Figure 10 PMID
Cavalot, F.; Miyata, M.; Vladutiu, A.; Terranova, V.; Dubiski, S.; Burlingame, R.; Tan, E.; Brentjens, J.; Milgrom, F.; Andres, G.
Immunization of rabbits with physicochemically altered homologous or even autologous IgG induces formation of antibodies combining with IgG of rabbit and of foreign species. Cardiac but not renal lesions were reported in such animals. This study examined the nephritogenic potential of the immune response to cationized or heat-aggregated homologous IgG of b9 or b4 allotype in rabbits of the b4 allotype. Rabbits injected with either b9 or b4 cationized IgG produced antibodies reactive with rabbit and human IgG and with histones; they also developed abnormal glomerular deposits of IgG b4 and C3 corresponding to alterations of the glomerular basement membranes (GBM). Rabbits injected with either b9 or b4 aggregated IgG developed antibodies reactive with rabbit and human IgG and abnormal glomerular deposits of IgG b4 and C3 in the GBM and in the mesangium with subendothelial and mesangial electron-dense deposits. Some rabbits in both groups had proliferative and exudative glomerulonephritis and proteinuria. The results showed that immunization of rabbits with physicochemically altered homologous IgG induces an immune response to rabbit and human IgG and to histones as well as glomerular deposits of autologous IgG and C3 and other glomerular lesions. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 Figure 23 Figure 24 Figure 25 Figure 26 Figure 27 Figure 28 Figure 29 Figure 30 PMID:1546743
Wirtschafter, J D
The pathophysiologic events in optic nerve axons have recently been recognized as crucial to an understanding of clinically significant acquired alterations in the ophthalmoscopic appearance of the optic disc. Stasis and related abnormalities of axonal transport appear to explain most aspects of optic nerve head swelling, including optic disc drusen and retinal cottonwool spots. Loss of axoplasm and axonal death can be invoked to interpret optic disc pallor, thinning and narrowing of rim tissue, changes in the size and outline of the optic cup, laminar dots, atrophy of the retinal nerve fiber layer, and acquired demyelination and myelination of the retinal nerve fiber layer. It is speculated that the axons may also play a role in the mechanical support of the lamina cribrosa in resisting the pressure gradient across the pars scleralis of the optic nerve head. Axons and their associated glial cells may be involved in those cases where "reversibility" of cupping of the optic disc has been reported. The structure, physiology, and experimental pathologic findings of the optic nerve head have been reviewed. Many aspects concerning the final anatomic appearance of the optic nerve head have been explained. However, many questions remain concerning the intermediate mechanisms by which increased intracranial pressure retards the various components of axonal transport in papilledema and by which increased IOP causes axonal loss in glaucoma. Investigation of the molecular biology of axonal constituents and their responses to abnormalities in their physical and chemical milieu could extend our understanding of the events that result from mechanical compression and local ischemia. Moreover, we have identified a need to further explore the role of axons in the pathophysiology of optic disc cupping. Images FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 11 FIGURE 12 FIGURE 13 PMID:6203209
Yi, E. S.; Lee, H.; Suh, Y. K.; Tang, W.; Qi, M.; Yin, S.; Remick, D. G.; Ulich, T. R.
Extrinsic allergic alveolitis and pulmonary sarcoidosis are granulomatous diseases of the lung for which clinical presentation and anatomic site of granuloma formation differ. Extrinsic allergic alveolitis is caused by inhaled antigens, whereas the nature and source of the inciting antigen in sarcoidosis is unknown. To test the hypothesis that the route via which antigen is introduced to the lung contributes to the clinicopathological presentation of pulmonary granulomatous disease, rats immunized with intravenous (i.v.) Corynebacterium parvum were challenged after 2 weeks with either intratracheal (i.t.) or i.v. C. parvum. The granulomatous inflammation elicited by i.t. challenge predominantly involved alveolar spaces and histologically simulated extrinsic allergic alveolitis. In contrast, the inflammation induced by i.v. challenge was characterized by granulomatous angiitis and interstitial inflammation simulating sarcoidosis. Elevations of leukocyte counts and TNF levels in bronchoalveolar fluid, which reflect inflammation in the intra-alveolar compartment, were much more pronounced after i.t. than after i.v. challenge. Tumor necrosis factor, interleukin-6, CC chemokine, CXC chemokine, and adhesion molecule mRNA and protein expression occurred in each model. In conclusion, i.t. or i.v. challenge with C. parvum in sensitized rats caused pulmonary granulomatous inflammation that was histologically similar to human extrinsic allergic alveolitis and sarcoidosis, respectively. Although the soluble and cellular mediators of granulomatous inflammation were qualitatively similar in both disease models, the differing anatomic source of the same antigenic challenge was responsible for differing clinicopathological presentations. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 11 Figure 13 Figure 12 Figure 14 PMID:8863677
Gamble, C. N.
Although hyaline arteriolosclerosis is very common and has been of interest to pathologists for well over 100 years, its pathogenesis has never been determined. This study demonstrates that iC3b bound via an ester linkage to hydroxyl groups on the repeating disaccharide units of hyaluronic acid is a major component of arteriolar hyaline. The deposition of iC3b within the walls of arterioles appears to be due to slow spontaneous activation of the alternative complement pathway and random binding of metastable C3b to proximate hyaluronic acid within the arteriolar wall. Since hyaluronic acid does not activate the alternative complement pathway, bound C3b is rapidly inactivated by factors I and H to iC3b, which, along with factor H, remains bound to hyaluronic acid. The hyaline in some hyalinized arterioles also contains IgM and early and late classical complement pathway components. Indirect evidence suggests that the IgM represents immunoconglutinin, an autoantibody to neoantigens on iC3b and that their interaction results in activation of the classical complement pathway. The gradual accumulation of iC3b, factor H, and, at times, IgM and classical complement pathway components within the walls of arterioles is considered to be a physiologic consequence of aging and probably cannot be prevented, because interruption of the initial binding of metastable C3b to hyaluronic acid would require abrogation of the critically important functions of the alternative complement pathway. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:2420184
Cook, Gray; Burton, Lee; Fields, Keith
Objective: To demonstrate the response to a proprioceptive training model during a 1-week rehabilitation regime. The techniques were demonstrated on a college-aged female basketball player who had injured her anterior cruciate ligament (ACL) several weeks earlier. The athlete was tested, trained, and then retested during her semester break. Background: The ACL injury has become a fairly common occurrence in the world of athletics. Knowing this, the athletic trainer is constantly searching for ways to improve the rehabilitative process. New research demonstrates that rehabilitation should be based on proprioception. The ACL not only serves a mechanical role by limiting passive knee mobility but also serves a sensory role through the mechanoreceptors deep in its tissue, which communicate with the neuromuscular system to provide proprioceptive feedback during training and competition. Differential Diagnosis: Partial or complete tear of the ACL. Treatment: The athlete was treated with a rehabilitation protocol based on proprioception, which uses reactive neuromuscular training. Uniqueness: Our rehabilitation focused on the muscular imbalances about the hip, knee, and ankle. The athlete achieved dramatic decreases in muscular imbalances about the hip and knee in only 1 week of rehabilitation through reactive neuromuscular training. Conclusions: The athlete had significant gains in strength over her brief period of therapy. However, these gains can be viewed only as neuromuscular changes and not strictly as gains in strength. The athlete returned to postseason competition under the supervision of her surgeon, who later recommended surgical reconstruction at the completion of the basketball season with rehabilitation during the offseason. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.Figure 8.Figure 9.Figure 10.Figure 11.Figure 12. PMID:16558562
Kurokawa, Y; Maekawa, A; Takahashi, M; Hayashi, Y
Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tumors, mesotheliomas of the peritoneum, and follicular cell tumors of the thyroid. In addition, experiments aimed at elucidating the mode of carcinogenic action have revealed that KBrO3 is a complete carcinogen, possessing both initiating and promoting activities for rat renal tumorigenesis. However, the potential seems to be weak in mice and hamsters. In contrast to its weak mutagenic activity in microbial assays, KBrO3 showed relatively strong potential inducing chromosome aberrations both in vitro and in vivo. Glutathione and cysteine degrade KBrO3 in vitro; in turn, the KBrO3 has inhibitory effects on inducing lipid peroxidation in the rat kidney. Active oxygen radicals generated from KBrO3 were implicated in its toxic and carcinogenic effects, especially because KBrO3 produced 8-hydroxydeoxyguanosine in the rat kidney. A wide range of data from applications of various analytical methods are now available for risk assessment purposes. Images FIGURE 1. FIGURE 2. FIGURE 5. FIGURE 6. FIGURE 7. FIGURE 8. FIGURE 9. FIGURE 10. FIGURE 11. FIGURE 12. PMID:2269236
Schindl, M; Wallraff, E; Deubzer, B; Witke, W; Gerisch, G; Sackmann, E
Reflection interference contrast microscopy combined with digital image processing was applied to study the motion of Dictyostelium discoideum cells in their pre-aggregative state on substrata of different adhesiveness (glass, albumin-covered glass, and freshly cleaved mica). The temporal variations of the size and shape of the cell/substratum contact area and the time course of advancement of pseudopods protruding in contact with the substratum were analyzed. The major goal was to study differences between the locomotion of wild-type cells and strains of triple mutants deficient in two F-actin cross-linking proteins (alpha-actinin and the 120-kDa gelation factor) and one F-actin fragmenting protein (severin). The size of contact area, AC, of both wild-type and mutant cells fluctuates between minimum and maximum values on the order of minutes, pointing toward an intrinsic switching mechanism associated with the mechanochemical control system. The fluctuation amplitudes are much larger on freshly cleaved mica than on glass. Wild-type and mutant cells exhibit remarkable differences on mica but not on glass. These differences comprise the population median of AC and alterations in pseudopod protrusion. AC is smaller by a factor of two or more for all mutants. Pseudopods protrude slower and shorter in the mutants. It is concluded that cell shape and pseudopods are destabilized by defects in the actin-skeleton, which can be overcompensated by strongly adhesive substrata. Several features of amoeboid cell locomotion on substrata can be understood on the basis of the minimum bending energy concept of soft adhering shells and by assuming that adhesion induces local alterations of the composite membrane consisting of the protein/lipid bilayer on the cell surface and the underlying actin-cortex. Images FIGURE 3 FIGURE 4 FIGURE 6 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 PMID:7756537
French, S. W.; Miyamoto, K.; Wong, K.; Jui, L.; Briere, L.
Eight pairs of young adult rats were pair-fed a high fat-low protein diet and ethanol or isocaloric glucose by permanent intragastric cannula for up to 6 months. Biopsies of the liver were taken monthly and the fibrosis was quantitated morphometrically using the sirius red polarization method of collagen visualization by light microscopy. Morphometric analysis of the sinusoids and scars were performed on electron micrographs made from the liver biopsies. An increase in the collagen in both the central and portal areas was found when the livers of the alcohol-fed rats were compared with controls. The predominant cell in the scars was the Ito cell. An increase in the percentage of the total Ito cell square area made up of rough endoplasmic reticulum (RER) was noted when the sinusoids of the liver of the ethanol-fed rats were compared with controls. No difference in the RER was found when the sinusoidal Ito cells were compared with the Ito cells located within the scars of the ethanol-fed rats. It was concluded that Ito cell "activation" by chronic ethanol feeding in the sinusoids of rats accurately predicts "activation" of the Ito cells within scars. The Ito cells are diffusely activated even though the scarring is localized. This implies that local factors as well as Ito cell activation are necessary for scar formation. In the case of alcoholic liver disease, scar formation may be initiated by centrilobular necrosis. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:3394803
Ausprunk, D. H.; Boudreau, C. L.; Nelson, D. A.
The ultrastructural organization of ruthenium red (RR) stainable material within small blood vessels located in the limbus of the rabbit eye was studied. Proteoglycans were identified in this material by digesting tissues with Streptomyces hyaluronidase, testicular hyaluronidase, chondroitinase ABC, or heparinase before ruthenium red staining. Neuraminidase digestion enabled separate identification of sialoglycoprotein. The luminal surface of endothelial cells demonstrates an RR-stained glycocalyx containing both sialoglycoprotein and proteoglycans, which are removed by testicular hyaluronidase and crude heparinase. The basal coat of endothelial cells and small granules (10-20 nm in diameter) located within the basal lamina stain with RR and are removed only by crude heparinase. The surface coat of smooth muscle cells and small granules (10-20 nm) within their basal laminas are also digested by crude heparinase. Large proteoglycan granules (20-50 nm), which are completely removed by testicular hyaluronidase and partially digested by Streptomyces hyaluronidase, are deposited between the connective tissue fibers of the media and adventitia. Other large granules that are attached to collagen fibers contain enzyme-resistant anionic materials. The surface coat of adventitial fibroblasts is removed only by crude heparinase. Thin filaments (3-5 nm in diameter) interconnect the cell coat material, basal lamina granules, and large connective tissue granules, to form a network of proteoglycans that traverses the intima, media, and adventitia. The highly ordered arrangement of proteoglycans in the microvascular wall suggests that these macromolecules play several roles in microvascular function. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:6165246
Maumenee, I H
One hundred sixty consecutive patients with the Marfan syndrome were reviewed for ocular, cardiovascular, and skeletal abnormalities, and were graded by severity. The most striking ocular abnormality was enlargement of the globe, presumably caused by scleral stretching. Staphylomata were not a feature of any of the patients seen, nor was keratoconus. The cornea, in fact, was flattened but not thinned. Among the 160 patients, 193 eyes showed dislocation of the lens. Dislocation of the lens was positively correlated with increased ocular axial length and with decreasing KJ readings. We postulate that the ocular pathologic changes are primarily caused by stretching of the tunica scleralis, and that the zonular fibers (thus under stress may "give" or may rupture in their area of presumably least density which may be the area of developmental fusion of the optic vesicle. In a small proportion of cases the lens dislocation was progressive. There was no correlation between ocular findings, on one hand, and the skeletal and cardiovascular abnormalities on the other. However, there was a good degree of intrafamilial consistency with regard to absence or presence of ocular pathology. The absence of correlation between the ocular and systemic findings in our data on these 160 patients is best explained by the existence of more than 1 point mutation, which may give rise to different but clinically similar phenotypes. The results of our calculations of mutation rate were compatible with such an explanation. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 2 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 9 FIGURE 10 FIGURE 12 FIGURE 13 A FIGURE 13 B FIGURE 13 C FIGURE 13 D PMID:7043871
Arkin, A; Ross, J
In prior work we demonstrated the implementation of logic gates, sequential computers (universal Turing machines), and parallel computers by means of the kinetics of chemical reaction mechanisms. In the present article we develop this subject further by first investigating the computational properties of several enzymatic (single and multiple) reaction mechanisms: we show their steady states are analogous to either Boolean or fuzzy logic gates. Nearly perfect digital function is obtained only in the regime in which the enzymes are saturated with their substrates. With these enzymatic gates, we construct combinational chemical networks that execute a given truth-table. The dynamic range of a network's output is strongly affected by "input/output matching" conditions among the internal gate elements. We find a simple mechanism, similar to the interconversion of fructose-6-phosphate between its two bisphosphate forms (fructose-1,6-bisphosphate and fructose-2,6-bisphosphate), that functions analogously to an AND gate. When the simple model is supplanted with one in which the enzyme rate laws are derived from experimental data, the steady state of the mechanism functions as an asymmetric fuzzy aggregation operator with properties akin to a fuzzy AND gate. The qualitative behavior of the mechanism does not change when situated within a large model of glycolysis/gluconeogenesis and the TCA cycle. The mechanism, in this case, switches the pathway's mode from glycolysis to gluconeogenesis in response to chemical signals of low blood glucose (cAMP) and abundant fuel for the TCA cycle (acetyl coenzyme A). Images FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 7 FIGURE 10 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 PMID:7948674
Schaffner, T.; Taylor, K.; Bartucci, E. J.; Fischer-Dzoga, K.; Beeson, J. H.; Glagov, S.; Wissler, R. W.
lysozyme or acid lipase activity. The occurrence of a population of cells with several functional and structural features of macrophages among the lipid-laden cells of experimental diet-induced arterial lesions suggests that some foam cells may be derived from monocytes. An alternative explanation, that metabolically altered autochthonous arterial wall cells assume one or more characteristics of mononuclear phagocytes is less likely, since some of the markers used in these experiments are unrelated. Both explanations deserve further careful study. Images Figure 1 Figure 2 Figure 3 Figures 4-7 Figures 8-11 Figure 12 Figure 13 Figures 14-16 PMID:6772035
... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Red King Crab Savings Area (RKCSA) 11 Figure 11 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 11 Figure 11 to Part 679—Red King Crab Savings Area (RKCSA) ER15NO99.009...
... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Red King Crab Savings Area (RKCSA) 11 Figure 11 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 11 Figure 11 to Part 679—Red King Crab Savings Area (RKCSA) ER15NO99.009...
... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Red King Crab Savings Area (RKCSA) 11 Figure 11 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 11 Figure 11 to Part 679—Red King Crab Savings Area (RKCSA) ER15NO99.009...
... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Red King Crab Savings Area (RKCSA) 11 Figure 11 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 11 Figure 11 to Part 679—Red King Crab Savings Area (RKCSA) ER15NO99.009...
... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Red King Crab Savings Area (RKCSA) 11 Figure 11 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 11 Figure 11 to Part 679—Red King Crab Savings Area (RKCSA) ER15NO99.009...
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Diagrams for Glossary of Terms 11 Figure 11 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 11 Figure 11 to...
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Diagrams for Glossary of Terms 11 Figure 11 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 11 Figure 11 to...
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Diagrams for Glossary of Terms 11 Figure 11 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 11 Figure 11 to...
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Diagrams for Glossary of Terms 11 Figure 11 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 11 Figure 11 to...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Diagrams for Glossary of Terms 11 Figure 11 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 11 Figure 11 to...
Bailey, G S; Williams, D E; Hendricks, J D
fish models can serve as highly useful adjuncts to conventional rodent models in the study of environmental carcinogenesis and its modulation. For some problems, fish models can provide wholly unique approaches. Images Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Figure 8. Figure 9. Figure 10. Figure 11. Figure 12. PMID:8722107
Nork, T M
FIGURE 4 FIGURE 5 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 15 FIGURE 16 FIGURE 18 FIGURE 20 FIGURE 21 FIGURE 22 PMID:11190032
Rao, N A; Hidayat, A
areas of deep retinitis/choroiditis. Contrary to the findings in Candida endophthalmitis, vitreous biopsy may not yield positive results in aspergillosis. Aspergillus endophthalmitis is usually associated with a high rate of mortality caused by cerebral and cardiac complications. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 PMID:11190022
Shultz, L. D.; Coman, D. R.; Bailey, C. L.; Beamer, W. G.; Sidman, C. L.
spermatogenesis. Images Figure 3 Figure 4 Figure 5 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:6380298
... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Bristol Bay Trawl Closure Area 12 Figure 12 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 12 Figure 12 to Part 679—Bristol Bay Trawl Closure Area ER30NO09.000...
... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Bristol Bay Trawl Closure Area 12 Figure 12 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 12 Figure 12 to Part 679—Bristol Bay Trawl Closure Area ER30NO09.000...
... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Bristol Bay Trawl Closure Area 12 Figure 12 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 12 Figure 12 to Part 679—Bristol Bay Trawl Closure Area ER30NO09.000...
... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Bristol Bay Trawl Closure Area 12 Figure 12 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 12 Figure 12 to Part 679—Bristol Bay Trawl Closure Area ER30NO09.000...
... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Bristol Bay Trawl Closure Area 12 Figure 12 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ALASKA Pt. 679, Fig. 12 Figure 12 to Part 679—Bristol Bay Trawl Closure Area ER30NO09.000...
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Labels for Domestic Mattress With Foundation 12 Figure 12 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 12 Figure...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Labels for Domestic Mattress With Foundation 12 Figure 12 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 12 Figure...
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Labels for Domestic Mattress With Foundation 12 Figure 12 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 12 Figure...
Pickreign, Jamar; Rogers, Robert
This article discusses relationships between the development of an understanding of algorithms and algebraic thinking. It also provides some sample activities for middle school teachers of mathematics to help promote students' algebraic thinking. (Contains 11 figures.)
McCollum, T.; Spector, G.B.
A flat response position sensitive neutron detector capable of providing neutron spectroscopic data utilizing scintillator fiber optic filaments embedded in a neutron moderating housing having an open end through which neutrons enter to be detected is described. 11 figures.
Suhr, Wilfried; Schlichting, H. Joachim
Beautiful colored interference rings can be produced by using transparent plates such as window glass. A simple model explains this effect, which was described by Newton but has almost been forgotten. (Contains 11 figures.)
Mammana, Maria Flavia; Micale, Biagio; Pennisi, Mario
In this note we show the existence of a surprising analogy between quadrilaterals and tetrahedra, determining some properties that hold for both families of figures. This analogy suggests some new properties of quadrilaterals. (Contains 11 figures,)
49 Appendix A. Communication between VBA and LINGO ...and LINGO Completion Times...............................................................64 Appendix D. Further Weighting Sensitivity Analysis for...Graph Representation .................................................................................11 Figure 2. LINGO Settings under Interface
hours after resuscitation. Characteristic pathological markers of hemorrhage were assessed by blood chemistry at three hours after hemorrhage, as...Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth, 2008. 11 Figure Legends. Figure 1 Blood chemistry analyses during resuscitation. Blood from
Crema FizzBuzz Program .................................................. 8 Figure 4: Hello World program written in C...11 Figure 5: Hello World program written in Crema...KLEE Coverage for " Hello , World" Program ................................................................ 14 Table 2: Qmail State-space Explosion
12 4.1 Development of the Surface Probability Function ( SPF ) Octree...15 5.2 SPF Terrain Model...terrain model and <….>. ..................................... 11 Figure 8: Visualization of our SPF Octree data structure using a sphere test surface
Braselton, James; Abell, Martha; Braselton, Lorraine
The Mobius strip, torus, and Klein bottle are used to graphically and analytically illustrate the differences between orientable and non-orientable surfaces. An exercise/laboratory project using the non-orientable Boy surface is included. (Contains 11 figures.)
the Scope of Interaction 4 Figure 3: IEEE Risk Management Process Model 11 Figure 4: Risk Management Process from AN/NZS 4360 11 Figure 5: Example...Identify risks • Analyze risks • Plan • Track • Control • Communicate10 | CMU/SEI-2006-TN-032 Figure 3: IEEE Risk Management Process Model Figure 4...statements made by Program-2? QUESTIONS ON PRACTICES What are the general implications for process models to achieve interoperable risk management
1-11 Figure 1-9. OQPSK block diagram...space OQPSK offset quadrature phase-shift keying p-p peak-to-peak PAM pulse-amplitude modulation PCM pulse-code modulation PLD path length difference...11 Figure 1-8. QPSK block diagram. 22.214.171.124.3 Offset Quadrature Phase-Shift Keying ( OQPSK ) Systems. The OQPSK transmission system, also known as
Acquisition Cycle Phases and Milestones 11 Figure 6 Expanding and Pruning of Design Considerations Throughout the Process 11 Figure 7 A Modified Scientific...Process Applied to Ship Design 23 Figure 15 A Simple Schematic Diagram of the Fraunhofer Efforts 24 Figure 16 Table-Top Gaming and Exercises 25 Figure 17...is a new way to use simulation for conducting trade-off analyses and for exploring very complex design spaces. SEA has the potential to progress
Method (1) This method places the deformable mirror in one arm of a Twyman -Green interferometer . The data from the interferometer is then analyzed...9 Figure 5: Setup of the Interferometer Method (1) ........................................................................ 10 Figure 6: Design of a... interferometer and fringe pattern analysis. Figure 5 shows the setup of the optical train of this method. 10 Figure 5: Setup of the Interferometer
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Jig for Setting Burners at Proper Distances From Mattress/Foundation 10 Figure 10 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 10 Figure 10 to Part 1633—Jig...
ES) 10 . SPONSORING/MONITORING AGENCY ACRONYM(S) Air Force Research Laboratory Sensors Directorate Wright-Patterson Air Force Base, OH... 10 Figure 4. ID-VDS characteristics illustrating the effect of the carrier density and longitudinal field dependent mobility terms... 10 Figure 5. ID-VGS characteristics
... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10...
... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10...
... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Jig for Setting Burners at Proper Distances From Mattress/Foundation 10 Figure 10 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 10 Figure 10 to Part 1633—Jig...
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Jig for Setting Burners at Proper Distances From Mattress/Foundation 10 Figure 10 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 10 Figure 10 to Part 1633—Jig...
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Jig for Setting Burners at Proper Distances From Mattress/Foundation 10 Figure 10 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt.1633, Fig. 10 Figure 10 to Part 1633—Jig...
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Jig for Setting Burners at Proper Distances From Mattress/Foundation 10 Figure 10 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 10 Figure 10 to Part 1633—Jig...
fingertips. 15. NUMBER OF PAGES 121 14. SUBJECT TERMS Intelligence, Peacekeeping, United Nations, UN, Peace Operations, OSINT, JMAC 16...10 Figure 2. Potential Intelligence Sources Available to UN Missions...............................10 Figure 3. JMAC Tasks...53 Figure 4. JMAC Information Flow
... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10...
... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Flounder TED 10 Figure 10 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig. 10 Figure 10...
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A of Part 1209—Insulation Radiant Panel Test Data...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A of Part 1209—Insulation Radiant Panel Test Data...
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A of Part 1209—Insulation Radiant Panel Test Data...
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A of Part 1209—Insulation Radiant Panel Test Data...
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Insulation Radiant Panel Test Data Log Format 10 Figure 10 to Subpart A of Part 1209 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1209, Subpt. A, Fig. 10 Figure 10 to Subpart A of Part 1209—Insulation Radiant Panel Test Data...
24 3. Description of the Testing Program on 18650 Cylindrical Cells...39 5. Finite Element Analysis Results for 18650 Cylindrical Cells and Pouch/Prismatic Cells ... 40 Estimation...Construction ...................................................................... 12 Figure 3: 18650 Discharge Characteristics
11 3. Reaction Wheel Upgrade...................................................................12 4...25 F. REACTION WHEEL SYSTEM...Interface onboard AUDASS II..............12 Figure 7. 20.3 N.m.s Reaction Wheel onboard AUDASS II...........................................13
Magnetic resonance methods in radiation chemistry are illustrated. The most recent developments in pulsed EPR and NMR studies in pulse radiolysis are outlined with emphasis on the study of transient radicals and their reaction products. 12 figures.
1-2 Figure 2. Example of Melanin Estimation on Skin Detections .................................................. 1-2 Figure 3...Comparision of a Hyperspectral Cube to a Multispectral Image ................................ 2-2 Figure 4. Human Skin Model Showing Effect of Melanin ...entire person to be exposed, just a single pixel of skin. The same body of work also presented the capability to estimate the melanin content of skin
Hercules (From USN, 2002) .................................................................12 Figure 5. C-40 Clipper (From USN, 2001...25,000 lbs. of cargo (USN, 2009b). 12 Figure 4. C-130 Hercules (From USN, 2002) Figure 5. C-40 Clipper (From USN, 2001) 13 Intermediate...2007a, 15 January). The U.S. Navy -- C-40A Clipper logistics aircraft. Retrieved from http://www.navy.mil/navydata/fact_display.asp?cid=1100&tid=600
Project Database Record . ...... 111-12 Figure 3.5 User Profile Record ... ........ 111-12 Figure 3.6 Project Save Store Record ..... .. 111-13 Figure 3.7...LOAD PROJECT , SAVE PROJECT, LOAD PROFILE, and SAVE PROFILE. When a save project command is entered by the user, the SAVE PROJECT subfunction stores the...functions allow the user to not have to repeatedly re-enter operating system commands. SAVE PROJECT and LOAD PROJECT save the information into a permanent
Davidson, S; Mansour, A; Gallily, R; Smolarski, M; Rofolovitch, M; Ginsburg, H
increased (from 0.12 microgram per 10(6) vacuolated cells to 3.02 micrograms per 10(6) mast cells). These mast cells were readily degranulated by monoclonal anti-DNP-BSA IgE, and the antigen, releasing 90% of the histamine. The study shows that mucosal mast cells formation from 'large lymphoid-like' cells present in the blood and in the lymph, is stimulated by TCF. The condensation of the metachromatic material and histamine synthesis depends on other cells, presumably fibroblasts which comprise the principal cell in the embryonic skin monolayers. The mechanism of the fibroblast influence is not yet known. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 PMID:6186596
Haik, B G
further study. Specimens from patients with intraocular hemorrhage should be viewed cautiously, since erythrocytes contain high levels of enolase. Analysis of subretinal aspirates is an extremely accurate method of confirming the diagnosis of Coats' disease. The key diagnostic findings are the presence of cholesterol crystals and pigment-laden macrophages and the absence of tumor cells on fresh preparations. The technique should be reserved for patients where retinoblastoma has been ruled out by all noninvasive means and massive subretinal drainage is anticipated. The natural progression in advanced Coats' disease is toward the development of a blind, painful eye. Spontaneous regression does rarely occur, and some eyes quietly progress to a phthisical state.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 2 FIGURE 3 FIGURE 4 A FIGURE 4 B FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 17 FIGURE 18 FIGURE 19 FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32 FIGURE 33 FIGURE 34 A FIGURE 34 B FIGURE 35 FIGURE 36 FIGURE 38 FIGURE 39 FIGURE 41 FIGURE 42 FIGURE 43 FIGURE 44 FIGURE 45 FIGURE 46 A FIGURE 46 B FIGURE 47 A FIGURE 47 B FIGURE 48 A FIGURE 48 B FIGURE 49 FIGURE 50 FIGURE 51 FIGURE 52 FIGURE 54 FIGURE 54 (cont.) FIGURE 55 FIGURE 57 FIGURE 58 FIGURE 59 FIGURE 60 FIGURE 61 FIGURE 62 FIGURE 63 FIGURE 64 FIGURE 65 FIGURE 66 A FIGURE 66 B FIGURE 67 A FIGURE 67 B PMID:1808814
Horton, J C
chiasm. It forms gradually over a period of years following monocular enucleation, presumably from shrinkage of the optic chiasm caused by atrophy of fibers from the enucleated eye. Therefore, the superior temporal hemianopia in the "other eye" seen in the anterior chiasmal syndrome cannot be due to compression of Wilbrand's Knee. I propose that it occurs from combined compression of the optic chiasm and one (or both) optic nerves. Images FIGURE 2 FIGURE 5A FIGURE 5B FIGURE 6 FIGURE 7 A FIGURE 7 B FIGURE 7 C FIGURE 7 D FIGURE 7 E FIGURE 7 F FIGURE 7 G FIGURE 7 H FIGURE 8A FIGURE 8B FIGURE 9A FIGURE 9B FIGURE 10 FIGURE 11A FIGURE 11B FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 16 FIGURE 18 FIGURE 20 PMID:9440188
Clinton, S. K.; Underwood, R.; Hayes, L.; Sherman, M. L.; Kufe, D. W.; Libby, P.
authors found no mRNA for the MCSF receptor, c-fms, in cultured EC or SMC macrophages are likely the primary target for MCSF within atheromatous vessels. The authors therefore investigated the effects of MCSF on monocyte functions related to foam cell development. Treatment of cultured human monocytes with recombinant human MCSF (10(3) U/ml, 72 hr) led to the accumulation of mRNA for the acetyl-LDL (scavenger) receptor and apolipoprotein E (apo E). These studies establish that vascular EC and SMC produce substantial MCSF in response to a variety of stimuli. The local production of MCSF during atherogenesis may contribute to macrophage survival and proliferation or activate specific macrophage functions such as expression of the scavenger receptor and secretion of apo E. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 8 Figure 9 Figure 10 Figure 12 Figure 13 PMID:1739124
communication multipoint (systèmes AMIGO) à point (station de base). Les images IR et toutes les autres données sont transmises par réseau sans fil à la...AMIGO) à point (station de base). Les images IR et toutes les autres données sont transmises par réseau sans fil à la station de base et la mise en...11 Figure 5. SyChip GPS2020 module (both sides )...................................................................... 11 Figure 6
orthoimagery on USGS Seamless Distribution System...............................................................................................10 Figure 6...ft orthoimagery , but the images did not load for this author. Site address: http://nationalmap.usgs.gov/. National map interactive viewer
7 7. Snow collection site in the Sangre de Cristo Mountains...1990). 10 Figure 7. Snwv collection site in the Sangre de Cristo Mountains. ranging from 100 to 520 kg m-3. Sintered snow with jectile impact, a signal
A9 Figure 10: Relief Valve, Manual, Air Tanks A10 Figure 11: Safety Pin , Launch Station A10 Figure 12: Upper Probe Attach Points All Figure 13: Lower...POSITION; SAFETY PIN IS ENGAGED; AND, SAFETY INDICATOR IS GREEN. A-19 2.5 LAUNCH CHECK LIST NOTE At this time, all lab personnel, clieuts and observers are...Launch Station Refer to Figure 11. Apply power to SAFETY light assembly. Release light assembly relay by manually retracting SAFETY pin . GREEN light
Strain ........................10 Figure 4. Normalized Displacement at Center of Top Skin Plate ...................................10 Figure 5...48 Figure 49. Experiment Strain Gage La yout on Underside of Composite Plate... skin plates, coupled through vertical stiffeners. Each skin plate is 0.3 m x 0.3 m and 0.002 m thick and is m odeled with e-glass com posite. The
coordinate patrol craft’s maritime interdiction process. 15. NUMBER OF PAGES 111 14. SUBJECT TERMS Multi - Agent System , Conceptual Blending...Using a Multi - Agent System ................. 13 3. Boyd’s OODA Loop Theory .................................................. 15 4. Military Decision...Network (From ).............................................. 11 Figure 3. Compounded Multi - agent System . ..................................................... 15
pp. 316–320 Available: IEEE Xplore , http://ieeexplore.ieee.org [Accessed: June 9, 2010].  N. Sidiropoulos, “Multiuser Transmit Beamforming...Mobile Mesh Segments of TNT Testbed .......... 11 Figure 5. Infrastructure and Ad Hoc Mode of IEEE 802.11................................ 13 Figure...6. The Power Spectral Density of OFDM................................................ 14 Figure 7. A Typical IEEE 802.16 Network
Hyperbolic geometry occurs on hyperbolic planes--the most commonly cited one being a saddle shape. In this article, the author explores negative hyperbolic curvature, and provides a detailed description of how she constructed two hyperbolic paraboloids. Hyperbolic geometry occurs on surfaces that have negative curvature. (Contains 11 figures and 4…
captive flameless heat generation. CDI’s unique success in achieving stabilization in captive combustion for light fuels such as methanol, ethanol and...7 4.3.2 Light Fuel Testing/Calibration (Methanol and Ethanol ).............................................. 10 4.3.3 Heavy Fuel Testing...9 Figure 3. Catalytic Combustion Data for Methanol & Ethanol ...................................................11 Figure 4. Catalytic
We use the computing technology digital image processing (DIP) to enhance the teaching of linear algebra so as to make the course more visual and interesting. Certainly, this visual approach by using technology to link linear algebra to DIP is interesting and unexpected to both students as well as many faculty. (Contains 2 tables and 11 figures.)
Figure 3 . Station Location Relative to Mean Aerodynamic Chord (MAC) ...................................................11 Figure 4. Tail Modification...Weight Growth During First Ten Years...................................................................14 Table 3 . Treatments...Boeing Aero, 2009: 3 ). Prior to this study, Boeing asserted that the aircraft not be operated below 7,000 lbs total fuel, undoubtedly a
10 Section 5 - Coanda Effect ............................................................................................ 11...11 Figure 9: Coanda effect : entrainment of air into the jet and jet deflection towards the...rotational velocity out of ground effect ............................... 36 Figure 27: Percentage difference in lift between Coanda nozzles and straight
Aplication Descriptors <Fl> HELP <F2> HEY HELP <PgDn> NEXT PANEL ə> NEXT FIELD <F7> END EDIT 8(i) <F3> FOR TABLE SEPARATE ITERATIONS WITH 1;1 Figure... THERMODYNAMICS : PARTITIONING: KINETICS SOLUBILITY(S) EXTRACTION 4 " DIFFUSION EQUILIBRIUM SORPTION/EXTRACTION/DIFFUSION ASTM D 471/D 543/D 896; ISO 1817
monsoon trough that moves over and north of the Marianas (Kodama and Businger 1998). The convergence of the cross-equatorial flow, Inter-Tropical...to deflect the southeast flow to the right creating westerlies. The resultant trough of low pressure induces a cyclonic spin and is known as a...monsoon trough . (After Elsberry, Chapter 1) .........................................................................................11 Figure 8
De Grauwe, Anton
Through narration and with the aid of 27 tables and 11 figures, this book reports on the school supervision system in four African countries. (The research is part of a larger series of studies sponsored by UNESCO and the International Institute for Educational Planning.) The countries studied were Botswana, Namibia, Tanzania, and Zimbabwe. The…
9. Roll angle history from the linear analysis. ...................................................................11 Figure 10. Roll rate angle ...moment derivative, and pitch damping. All coefficients are functions of Mach number and some are functions of angle of attack. Specific functional...summation of control forces and moments due to the ith control surface. Note that dynamic pressure and angle of attack are calculated locally at each
9 Figure 7. Snow density by day of year at Sault Ste Marie , Duluth, and in the Lake Superior watershed and vicinity in Ontario...Canada ....................................................................................11 Figure 8. Snow density histogram for Sault Ste Marie ... Marys River. The outflow from Lake Superior is controlled under stringent regulation plans agreed upon by Canada and the United States through the
SUPPLEMENTARY NOTES 14. ABSTRACT Systemic sclerosis is a potentially devastating multisystem disorder characterized inflammation and autoimmunity...expression is increased in fibrotic tissues from lungs of patients with idiopathic pulmonary fibrosis and skin of patients with systemic sclerosis...mouse (red) Cad-11 Figure 3. Serum cadherin-11 levels are increased in certain autoantibody subsets of systemic sclerosis using a commercial
tensile and compressive plate-impact tests, long-rod penetration of prestressed targets, long-rod penetration of confined targets, long-rod penetration...10 3.3 Prestressed Long-Rod Penetration...11 Figure 6. Results of tungsten long-rod impacts with thick prestressed silicon- carbide targets from tests [12
beta (TGF-β) and stromal cell derived factor-1 ( SDF -1) as being overexpressed in CAF cells. These factors were 11 Figure 7. Stromal specific...expressed in cancer associated fibroblasts (CAFs) (including cyclin D1 [CD1], TGFß and SDF -1) induce tumorigenesis and malignant transformation in tissue
Schlenker, Richard M.
This manual is a "how to" training device for formatting blank floppy disks in the AppleWorks program using an Apple IIe or Apple IIGS Computer with Duodisk or two disk drives. The manual provides step-by-step directions, and includes 11 figures depicting the computer screen at the various stages of the formatting sequence. (EW)
regulatory document developed Laboratory equipment and reagents purchased Test methodology refined for cold stored platelet radiolabeling, aggregation and...STUDY SCHEMA 11 FIGURE 2. FLOW OF STUDY PROCEDURES 17 Puget Sound Blood Center Protocol: 12-1, Revision 7/17/2013...provide RBCs , plasma and platelets in forward combat situations without the need to separate the blood into components. Therefore these platelets need
DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated. 11 figures.
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures...
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures...
... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Modified Flounder TED 11 Figure 11 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig....
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures...
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures...
... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Modified Flounder TED 11 Figure 11 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig....
Gyulai, Peter; Rabieh, Mohammad Mahdi; Seraj, Ali Asghar; Ronkay, Laslo; Esfandiari, Mehdi
A new Anagnorisma species, Anagnorisma chamrani sp. n., is described from Binaloud Mountains of Khorasan-e-Razavi province in north-eastern Iran, and compared with its sister species, Anagnorisma eucratides (Boursin, 1960). The adults, and male and female genitalia of both species are illustrated in 11 figures. The genus Anagnorisma is recorded for the first time for the fauna of Iran.
Selection Team Roles and Responsibilities for TRICARE’s Contract Award Process 11 Figure 3: Timeline of Bid Protest Events for TRICARE’s North Region...14-195 TRICARE Managed Care Support Contracts Figure 2: Source Selection Team Roles and Responsibilities for TRICARE’s Contract Award Process
Bostan, Ion; Canter, Valeriu; Secrieru, Nicolae; Bodean, Ghenadie; Blaja, Valeriu
This paper deals with the main current results of investigation , designing and manufacturing of functional components of microsatellite, obtained in the State investigation programm, "Valoristaion of renewable energy in the Republic of Moldova and development of Moldavian Satellite". The satellite will have a mass of 12.5 kg. The paper contains 8 chapters, 11 figures, 11 bibliographical references.
Warner, B.E.; Duncan, D.B.
Laser beam generating apparatus including a septum segment disposed longitudinally within the tubular structure of the apparatus. The septum provides for radiatively dissipating heat buildup within the tubular structure and for generating relatively uniform laser beam pulses so as to minimize or eliminate radial pulse delays (the chevron effect). 11 figures.
... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Modified Flounder TED 11 Figure 11 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Pt. 223, Fig....
... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false 11 Figure 11 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Figure 11 to Part 223...
11 Basic automated motion using software ... mockup horizontally and vertically. Gripping force testing Pulling in an axial direction the gripper assembly achieved 36.33lbs of gripping force...bags being partially inflated (Figure 11). Figure 11 - Gripper sleds Basic automated motion using software The robot successfully ran on auto
Markram, H; Lübke, J; Frotscher, M; Roth, A; Sakmann, B
Images Figure 1 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 20 Figure 22 PMID:9147328
Schlick, T.; Li, B.; Olson, W. K.
supercoiled DNA function, not only for closed circular DNA,but also for linear DNA with small looped regions. Images FIGURE 11 FIGURE 12 FIGURE 13 FIGURE 14 FIGURE 15 FIGURE 16 FIGURE 19 FIGURE 21 PMID:7696459
2 2.2 Standard Vacuum Assisted Resin Transfer Molding ( VARTM ) with SC-15 Resin .......2... VARTM ). ................................................9 Figure 7. Force vs. displacement for Hybrid no. 5...12. C-scan image showing progression of delamination in Hybrid no. 4 (PA- VARTM ). 12 Figure 13. C-scan image showing progression of delamination in
moisture capacity (FMC) by controlled water addition...................... 8 Figure 3. Mushroom substrate (exhibiting vigorous fungal growth...12 Figure 4. McGuire AFB soil with used mushroom substrate ...chlordane concentration in two soils as a result of incubating with used mushroom substrate
Fermat's principle is considered as a unifying concept. It is usually presented erroneously as a "least time principle". In this paper we present some software that shows cases of maxima and minima and the application of Fermat's principle to the problem of focusing in lenses. (Contains 12 figures.)
11 b. Business Process Model and Notation ( BPMN ) ....................12 c. Entity Relationship Diagrams (ERD...diagram (From EETimes Website Authors, 2011) ...........12 Figure 9. BPMN example diagram (From Wikipedia contributors, 2012) .....................13...Association for Computing Machinery BPMN Business Process Model and Notation DAG Directed Acyclic Graph DOM Document Object Model ERD Entity
unless so designated by other authorized documents. DESTROY THIS REPORT WHEN NO LONGER NEEDED. DO NOT RETURN IT TO THE ORIGINATOR. ERDC/EL TR-11-3...12 Figure 7. Treated slurry before and after centrifugation ...conceptual model of actual application procedures as a guide for our experimental design . We envision that a team will take the chemical amendments
Elliptical Nebulae NGC 3115 and 4494,” Astrophysical Journal, vol. 191, p. 273. 12 Figure 3: Edge-on model of the Milky Way galaxy. “Halo” refers...Structure and Dynamics of the Galactic System and the Elliptical Nebulae NGC 3115 and 4494.” Astrophysical Journal, vol. 191, p. 273. Parker
Application Center (AUVAC) Web site .........................2 Figure 2. Compilation of UUV Master Plan graphics  illustrating Sea Power 21 Pillars...Gavia Offshore at Caspian Sea , from .......................................................38 Figure 49. Boeing’s Echo Ranger, from [1...runs from relatively unproven laboratory single units to production vehicles that have logged thousands of at- sea operational hours. Figure 1 shows
Tousignant, J.; Côté, B.; Barolet, D.
Urticaria is often incapacitating, yet it is not always easy to know whether a patient should undergo testing and what treatment should be prescribed. This article provides a systematic approach to urticaria and its treatment. Images Figures 1-2 Figures 3-4 PMID:8435550
Bernhardt, A.F.; Contolini, R.J.
In a process for fabricating planarized thin film metal interconnects for integrated circuit structures, a planarized metal layer is etched back to the underlying dielectric layer by electropolishing, ion milling or other procedure. Electropolishing reduces processing time from hours to minutes and allows batch processing of multiple wafers. The etched back planarized thin film interconnect is flush with the dielectric layer. 12 figures.
composite fire, AFFF, MIL-F-24835F, UHP , firefighting gel, extinguishment U U U UU 33 Brent M. Pickett Reset i Distribution A: Approved for public...12 Figure 8. (a) Temperature and (b) Total Heat Flux for Representative AA and UHP Test Runs...13 Figure 9. Photograph Following UHP Extinguishment, Showing
used include Walker constellation parameters, orbital elements, and transmit power. The results show that the constellation design tool produces...10 2.1.1 Orbit Types. .................................................................................................. 2-11 2.1.2 Astrodynamics...Constellation Design Problem ........................................................ 1-2 Figure 2-1: Classical Orbital Elements
Director US Army, Targets Management Office 3 4 Table of Contents 1.0 SUMMARY 7 2.0 INTRODUCTION 7 3.0 METHODS, ASSUMPTIONS, AND PROCEDURES 9...Vehicle Survivability Design Philosophy ........................................................ 12 Figure 3 . Ground vehicle survivability layer details...20 Table 3 . APC proliferation, quantities, production status, and projections .................................. 21 Table 4. SAM
MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution... 12 Figure 9. Schematic of laser and UV mold movements. .............................................................. 12 ...processing apparatus. .........................................................13 Figure 12 . Images of UV photopolymer samples, (l-r): sample with
12 Figure 2.2. Pitot Tube...that relay pitot -static information from the aircraft’s air data system and inertial measurement information from the Inertial Navigation System...Air data systems receive total and static pressure inputs from a pitot -static system. A typical pitot tube, as shown below, receives total pressure
CONCLUSIONS AND FUTURE RESEARCH Research is to see what everybody else has seen, and to think what nobody else has thought. - Albert Szent - Gyorgyi ...xx Figure 5. Coevolution and the Shift to Network-Centric Operations (From Alberts , Garstka, and...Adversary (From Alberts , Garstka, and Stein 1999, 56)............................................................................12 Figure 7. Global
conclusions and recommendations for Phase II of the Flexible Display Program. 15. SUBJECT TERMS LIGHT EMITTING DIODES LIQUID CRYSTAL DISPLAY SYSTEMS...space for Phase I and II confined by backplane complexity and substrate form...12 Figure 6. Semi automated I-V curve measurement setup consisting of Keithley power supply, computer and
24 Measures of Stress...Figure 2: Suicide and Suicide Related Behaviors (Berman, 2010) .................................. 12 Figure 3: Developing Comprehensive Suicide...2010). The emphasis placed on suicide prevention within the DoD has led to the development of numerous initiatives to reduce the risk of suicide
test section. 43 lrann,sionlin fo si alIransmission line for signal R:CaQ itive Feedl-throoph capacitor Probe Transmiission linefor pulsar Ir ansmission...line for pulsar Contact 49 Ou~ter shieldsufc nte wir C. 3Q9x 12 Figure 3. Schematic of a back current shunt. Figure 4. Schematic and an equivalent
Email Agents ___________________________________________________________________ 22 3.4.2 Palm Pilot Agents...12 Figure 7: PDA ( Palm VII) with GPS device for wireless, handheld communication between proxy and user. __ 14...while reducing the burden on humans. Tied to individual user workstations, fax machines, voice, mobile devices such as cell phones and palm pilots
Liu, P.K.T.; Gallaher, G.R.; Wu, J.C.S.
A method is described for producing a carbon coated ceramic membrane including passing a selected hydrocarbon vapor through a ceramic membrane and controlling ceramic membrane exposure temperature and ceramic membrane exposure time. The method produces a carbon coated ceramic membrane of reduced pore size and modified surface properties having increased chemical, thermal and hydrothermal stability over an uncoated ceramic membrane. 12 figures.
either execute a contract for outside design services (i.e. Architect and Engineer services); generate detailed designs and specifications in... Architect and Engineer providers (H. Pablo, personal communication, 2015). 12 Figure 5. Financial Management Headquarters Organization Chart...constructability reviews. There are also costs associated with having an engineer or architect review plans and submittals from contractors and in
Free vortex wake (Scully) ! 7. Wind turbine induction flow (rotors only) a 1...Scissor Tail Rotor Variant 7 Figure 4. RPM Sensor Installation (17) 12 Figure 5. Accelerometer and Tachometer Installation locations. (17) 13 Figure...weight adjusted made to the aft pocket. (17) An accelerometer is used to measure the accelerations in vertical direction. An optical tachometer is
branches and tubes that change diameter. 4. Musical Instrument Design A flute is essentially a hollow tube with a way at one end to modulate the...an integer (1,2,3,…). 12 Figure 5. Tube with no holes. The addition of a side branch effectively changes the length of the tube, so in a flute
Mass yields of the spontaneous fission of Fm isotopes, Cf isotopes, and /sup 259/Md are discussed. Actinide yields were measured for bombardments of /sup 248/Cm with /sup 16/O, /sup 18/O, /sup 20/Ne, and /sup 22/Ne. A superheavy product might be produced by bombarding /sup 248/Cm with /sup 48/Ca ions. 12 figures. (DLC)
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Labels for Domestic Mattress With Foundation 12 Figure 12 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 12...
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Labels for Domestic Mattress With Foundation 12 Figure 12 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY (OPEN FLAME) OF MATTRESS SETS Pt. 1633, Fig. 12...
IEEE Spectrum Online Article, "Re-engineering Iraq,” Feb. 2006.)....................................................................5 Figure 5...Capstone Microturbines (Source: Capstone Turbine Coorperation) ..............12 Figure 6: Caterpillar Model 3406C 300kW Reciprocating Diesel...Generator (Source: Caterpillar ) .......................................................................................................13 Figure 7
Titan III -.?Titan IV b. Atlas ICBM-.?Atlas SLV -.?Atlas 11 c. Delta IV medium-.? Delta IV heavy 2. Leverage entire propulsion systems from an...lM-2C . Atlas 10-Mercury . Strela TItan II SlV :!t Zenit 2 . Angara 1.1 . Angara 1.2 Figure 11. Historical TSTO Thrust Tum-Down Ratio 55TO
... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Escape Opening & Cover Dimensions for 71-inch TED 12 Figure 12 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE...
... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Escape Opening & Cover Dimensions for 71-inch TED 12 Figure 12 to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE...
7 T 20o= Figure 5. Tonpilz transducer frequency response (After Ref... Tonpilz trans- ducer with a matching layer is shown in Figure 5 . Figure 5. Tonpilz transducer frequency response (After Ref. 12.) B...Monterey, California, 2002. 118 12. Hannah Kessler, Spyridon Dessalermos, Vassilios Karakikes and Konstantinos Tsaprazis, Tonpilz Transducer Project
16 OR 114). These consisted primarily of late nineteenth century to early twentieth century artifact deposits; no structural remains were noted. The...former location of plantations and standing structures within the project area ............................................ 12 Figure 3. Redrawn Braun...Fire Insurance Map of 1877, showing standing structures formerly located between Montegut Street and Clouet Street
Harris, G J; Garcia, G H; Logani, S C; Murphy, M L; Sheth, B P; Seth, A K
intrinsic damage and subsequent fibrosis, appear to result in poorer motility outcomes. Although this retrospective study does not conclusively prove its benefit, an urgent surgical approach to selected injuries should be considered. Images FIGURE 1 FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 PMID:10360296
was covered with approximately 3/16” of Rhino Liner , seen in Figure 5 below. The additional coating only added approximately 8 ounces and greatly...determined that a much greater amount of energy would be required to lift the bag and thus a compressed air cylinder was selected as the source of...power. 11 Figure 10 - Battery operated air compressor Compressed air cylinders have the ability to be filled offsite and hold their
6: Bandicoot 11 Figure 7: Deployer mast in a.) retracted, b.) extending, and c.) fully extended positions. 13 Figure 8: Wombat climbing stairs with...mast in a.) retracted, b.)extending, and c.) fully extended positions. 13 Deploy er Outfitting - Wombat The second Urban Robot, Wombat (Fig.8), was...equipped with a single, rear-mounted ISIS transceiver and a Swarm Radio to communicate with all of the Joeys. In addition, Wombat was equipped with
between actual and reported trigger onset time) measured with the Emotiv Epoc EEG headset......................................................10...11 Figure 6. Data recorded using the Emotiv Epoc system in conjunction with a phantom head device. Natively reported data...Alert 2.45*), Biosemi Active2 (ActiView 6.05), Emotiv Epoc (TestBench 126.96.36.199), and Quasar Helmet-Mounted System (HMS) (QStreamer 1.5.1046). All
Height mechanism . . . . . . . . . . .10 12. Rear leg wheel . . , . -. . . 13. Safety pin .. ..* .- ,. *,. .. . 12 14. Rear quarter view of platform...for seat-back support (Fig. 14) is detachable at its top end by removal of a quick-connect/disconnect pin. This pin, like the safety pin discussed...wheel. 11 Figure 13. Safety pin . Figure 14. Rear quarter view of platform/chair. Arrow points to removable pin for backrest mechanism. 12 The width of the
Measurements of Attenuation and Talk-through Amplification for Two Communications Headset Candidates for the Helmet Electronics and Display System-Upgradeable Protection (HEaDS-UP) Army Technology Objective (ATO)
attenuation, except for the CVC in the active noise reduction ( ANR ) configuration. Error bars refer to standard error...separately and for the Bose headset with the ANR turned on. Error bars refer to standard error. All values shown are for passive attenuation...except for the Bose® CVC headset in the ANR configuration. ..............11 Figure 8. Measurements made with the talk-thru turned on: (left) The signal
ammonium sulphate . 11 Figure 12. SDS–PAGE (12%) analysis of heat treatment of recombinant SOD. Lane 1, markers; Lane 2, TC; Lane 3, CFE; Lane 4...16 After several trials we could obtain the catalase sequence. The catalase gene from I1P has 1437 nucleotides. The protein contains 478 amino acid ...protein preservation. The protein was maintained active in 3.2 ammonium sulphate . Figure 22. SDS-PAGE (12 %) analysis of IMAC purification fractions
nanowire materials  and thin layers of solar cells . To measure the diffusion length of bulk materials is a new challenge. Specifically, a...ZnS, Zr02, GaAs , ZnSe & CdTe) at 10 keV with the probe current 3E-10 A...11 Figure 12 Luminescence distribution as a function of position for six samples (SiC, ZnS, Zr02, GaAs
11 Figure 6: Closed-Loop Responses Due To Statistical Controller Design......................... 13 Figure 7: Reaction Wheel and Thruster Torques Due...of self awareness. The outline of the research goes as follows. First, a brief modeling of satellite with reaction wheels and thrusters will be...7 shows the control action from both reaction wheel cluster and thrusters. It was noted that the action of statistical controller was large at the
subsystem is inherently underactuated . The systems are coupled via the fact that the rotational velocities appear in the Coriolis force that acts on...and yaw angle is designed using the output feedback and estimated states based on the error dynamics of the underactuated UAV system . 11 Figure 2...Nagarkatti, and F. Zang, Lyapunov-based Control of Mechanical Systems , Birkhauser, 2000.  H. Berghuis and H. Nijmeijer, “A Passivity Approach to
4,4’DDT. b. Aroclor 1254 ................ B6 Figure B 11. Contaminant concentrations in sediments. a. Dibutyltin . b. Tributyltin...bioaccumulation in organisms. a. Inner. b. Hot. c. Reference ............... B11 Figure B17. Dibutyltin bioaccumulation in organisms. a. Inner. b. Hot. c... Dibutyltin bioaccumulation from BS and S50. a. Inner. b. Hot. c. Reference ............ E17 Figure B23. Bioaccumulation of metals from Outer BS and S50
aiming a weapon is referred to as gun laying. This report describes a method to calculate motion profiles that reach a given lay within the least...amount of time while reducing the amount of peak power required and, therefore, minimizing the forces caused by acceleration. 15. SUBJECT TERMS...Calculating New Acceleration Values 5 Results and Discussions 7 Conclusions 10 Distribution List 11 FIGURES 1 Trapezoidal motion profile 1 2
extraction / recovery process, and Table 3 pre- sents the results for conventional properties of the AC samples. ERDC/GSL TR-07-18 13 Figure 11...Figure 7, cores were extracted on site and the beams were sawn in the laboratory. Once the in situ modulus was obtained with the PSPA and the cores...were extracted , the sample was sawed and removed, and the hole was patched. Portable seismic pavement analyzer tests The PSPA (Figure 10), developed
Energy transfer in chelates of Eu/sup 3 +/ with ligands (dibenzylmethane) was studied as a function of pressure. Rate of thermal dissipation of electronic excitation was correlated with viscosity and dielectric constant for indoles in a series of solvents, and with pressure for porphyrins. Effects of medium (dielectric constant, viscosity) on complexes were studied. Studies on 3-hydroxyflavone are also summarized. These studies show the power of high pressure luminescence as a tool in chemical physics. 11 figures. (DLC)
turbine engine . 15. NUMBER OF PAGES 70 14. SUBJECT TERMS: Turbine blade ; Film cooling ; Pulsed jet 16. PRICE CODE 17...with additional research, ultimately allowing for an increased efficiency in a gas turbine engine . 2 Keywords Turbine blade Film cooling Pulsed jet ... engine for aircraft propulsion…………………. 11 Figure 2: Thermodynamic cycle of a general turbine engine . ………………………..…… 11
plasma half-life (1-3 h) associated with a correspondingly limited duration of analgesic effect.2 Under certain circumstances, longer-acting morphine...subjected to UPLC. ANDM allows both deproteinization as well as the release of protein -bound MP.11 -Figure 2- Baseline UPLC values of ANDM treated...blood coagulation proteins nor the added anticoagulant in the plasma samples influence the hydrolytic process. The released morphine was tested for
A Mutually-Orthogonal Usercode-Receiver ( AMOUR ) for asynchronous or quasi-synchronous CDMA systems. AMOUR converts a multiuser CDMA system into...of improving the performance of AMOUR systems. They design Fractionally-Spaced AMOUR (FSAMOUR) receivers with integral and rational amounts of...practically guaranteed. They exploit this flexibility in the design of AMOUR and FSAMOUR receivers and achieve noticeable improvements in performance. (11 figures, 23 refs.)
shock (Adapted from Guyton , Textbook of Medical Physiology).11 Figure 2. Course of arterial pressure in dogs after different degrees of acute hemorrhage...Each curve represents the av- erage result from six dogs ( Guyton , Textbook of Medical Physiology).11 Voelckel et al. The Journal of TRAUMA® Injury...systemic hemodynamics in catecholamine-resistant septic and post- cardiotomy shock: a retrospective analysis. Anesth Analg. 2001;93: 7–13. 11. Guyton AC
Benson, D.K.; Crandall, R.S.; Deb, S.K.; Stone, J.L.
A variable transmittance double pane window includes an electrochromic material that has been deposited on one pane of the window in conjunction with an array of photovoltaic cells deposited along an edge of the pane to produce the required electric power necessary to vary the effective transmittance of the window. A battery is placed in a parallel fashion to the array of photovoltaic cells to allow the user the ability to manually override the system when a desired transmittance is desired. 11 figures.
cope with these kinds of compensation relations between variables. 11 Figure 4: Balance beam of the kind first used by Inhelder and Piaget (1958), and...developed by Inhelder and Piaget (1958), the so-called ba/ance-beam task, Is Eustrated In Figure 4. In this task, the child is shown a balance beam with pegs... Piaget stressed the continuity of the accomodation process, in spite of the overtly stage-like character of development, though he never gave a
savings are expected from maintenance actions taken from early diagnosis of faults prior to significant, in-flight failures. The VMEP system has been...shown in the points from D to E to F. Figure 10 – Polar Trend 4. FAULT DETECTION EVENTS Loose Gearbox Mount AH-64A aircraft tail number 86-09002 was...and the corresponding fault summary display is shown in Figure 11. Figure 11 - Loose Gearbox Mount CI display A visual inspection of the tail
shown below: - Assiston ’rofessor of Industria En neeDate Industrial Engineering * y* ACKNOWLEDGEMENTS I would like to thank Dr. John W. Giffin for his...was written in BASICA on an IBM Personal Computer. Due to the amount of memoru available in BASICA , the problem size is somewhat limited however; 11...Figure 4.13. Example III Block Plan with 3 facilities not included To provide a complete block plan, the BREAK feature of BASICA is used. Before
11 Figure 4. New Mexico and Texas study site locations ......................................................... 15 Figure 5...Mexico and two sites were located in Texas . The sites provided a wide range of sizes, spanning from 1 to 774 square miles. A comparative analysis of...demonstration. Six of the sites were located in New Mexico, and two were in Texas . Figure 4 presents a map of the study site locations. These sites
registrations indicate an overall improvement In. quality of patents obtained by Japanese applicants In the United States. (Figure 11) 11 Figure 11 Changes...JPRS-JST-92-005 26 FEBRUARY 1992 FOREIGN BROADCAST INFORMATION SERVICE .JPRS Report- Science & Technology Japan WHITE PAPER ON SCIENCE & TECHNOLOGY...JST-92-005 26 FEBRUARY 1992 SCIENCE & TECHNOLOGY JAPAN WHITE PAPER ON SCIENCE & TECHNOLOGY 1991 43070001 Tokyo WHITE PAPER ON SCIENCE AND TECHNOLOGY
Services Taxonomy (From Assad, 2012, p. 2) .....10 Figure 5. Service Portfolio Groups (From Assad, 2012, p. 4...the “ taxonomy ” of these service PSCs. A breakdown of the nine service portfolio groups and how many codes, categories, and portfolios that are in...DoD-Wide Acquisition of Services Taxonomy (From Assad, 2012, p. 2) 11 Figure 5. Service Portfolio Groups (From Assad, 2012, p. 4) 12
Regenerative heat exchangers are described for transferring heat between hot and cold fluids. The heat exchangers have seal-leakage rates significantly less than those of conventional regenerative heat exchangers because the matrix is discontinuously moved and is releasably sealed while in a stationary position. Both rotary and modular heat exchangers are described. Also described are methods for transferring heat between a hot and cold fluid using the discontinuous movement of matrices. 11 figures.
U.S. Defense Spending vs. the World ......................................................11 Figure 3. Military Expenditures in Western Europe...are as follows: - What are the global trends in defense spending /military expenditure ? - What are the global trends in the defense market? - What are...Institute (SIPRI) defines it in a broader concept. Defense spending or military expenditure is presented by SIPRI as follows: 7 “Where possible
finished blade, e-beam welding on a cover, which shows a variation of less than ±0.5% in corrected speed and then finish machining. The bleed air is...with section of leading edge due to distortion during welding .......................................... ... 64 11 Figure 4.20: Inadequate weld joints...that the CO2 might solidify. It is also important to note that the mixture ratio is set so that at standard day conditions the ratio of specific heats
14. SUBJECT TERMS Fluid Structure Interaction, FSI, composite, balsa, low velocity impact, sandwich composites, VARTM , Vacuum Assisted Resin Transfer...11 1. Vacuum Assisted Resin Transfer Molding ( VARTM ) ...................11 2. Procedure...required equipment for VARTM composite production. ..............10 Figure 4. VARTM Lay-up (From [8
Derivation of the law of radioactive decay is considered without prior knowledge of calculus or the exponential series. Calculus notation and exponential functions are used because ultimately they cannot be avoided, but they are introduced in a simple way and explained as needed. (Contains 10 figures, 1 box, and 1 table.)
... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Center of Gravity for Drop Assembly 10 Figure 10 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY... Gravity for Drop Assembly ER10MR98.010...
... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Center of Gravity for Drop Assembly 10 Figure 10 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY... Gravity for Drop Assembly ER10MR98.010...
... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Center of Gravity for Drop Assembly 10 Figure 10 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY... Gravity for Drop Assembly ER10MR98.010...
... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Center of Gravity for Drop Assembly 10 Figure 10 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY... Gravity for Drop Assembly ER10MR98.010...
... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Center of Gravity for Drop Assembly 10 Figure 10 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY... Gravity for Drop Assembly ER10MR98.010...
bladed Turbine ......................................................... 10 Figure 3. Wind Turbine Gearbox ..................................................................................... 10... Turbine Gearbox (DOE, 2003) - 11 - The foundation square footage required of the turbine is relatively small but the height is great. The...Figure 2. A Horizontal-axis Three-bladed Turbine (Vision Quest Windelectric, 2003) Figure 3. Wind
17. Dining area of lobby/dining room, view to south-southeast. Scale stick visible at left against corner of pillar; 5'10" figure for additional scale reference. - Deetjen's Big Sur Inn, Big Sur Inn Building, East Side of State Highway 1, Big Sur, Monterey County, CA
5 2.2 M IL-STD -1629 Tasks, ................................................................................................ 7 3.0 FMEA ...93 10.0 ADDITIONAL SOURCES/METHODS ................................................................ 95 10.1 Process FMEA ...CRTA-FMECA vii LIST OF FIGURES Page Figure 1: FMEA Worksheet (Task 101) .................................................................... 10 Figure 2
of hopper dredges at any of the coastal entrances, the Columbia River , the Umpqua River , or in most of Coos Bay. Overflow is restricted at river mile...Valley Division................................... 32 Ohio River Division................................................. 32 North Atlantic Division...transported and permanently deposited outside the navigation 10 Figure 2. Clamshell dredge filling scow with overflow channel by tidal, river , or
Daniel, John S
This book explores the essentials of distance education and reviews issues facing large open universities (mega-universities) worldwide. It uses examples from industry and the knowledge media, to show how technology-based learning can be made attractive both to students and to institutions. The book's eight chapters, including 10 figures and 5…
A general overview of the nucleosynthesis mechanisms for heavy (A greater than or equal to 70) nuclei is presented with particular emphasis on critical data needs. The current state of the art in nucleosynthesis models is described and areas in which fission product data may provide useful insight are proposed. 33 references, 10 figures.
Edwards, Michael Todd
This article highlights a project that encourages students to connect reading and mathematics instruction by using a data analysis approach. Students analyze sonnets from statistical, literary, and historical points of view in an effort to uncover the true identity of William Shakespeare. (Contains 10 figures.)
Minh, N.Q.; Horne, C.R.
In a two-step densifying process of making a monolithic solid oxide fuel cell, a limited number of anode-electrolyte-cathode cells separated by an interconnect layer are formed and partially densified. Subsequently, the partially densified cells are stacked and further densified to form a monolithic array. 10 figures.
6 DARPA Vulture Program...2003) 10 Figure 7. Boeing’s Phantom Eye UAV  Figure 8. RQ-4 Global Hawk  11 DARPA Vulture Program The Defense...Advanced Research Projects Agency’s (DARPA) Vulture Program aims to push the goals of these previous efforts even further. DARPA set a goal of
Wanko, Jeffrey J.
This article details an exploration of exponential decay and growth relationships using M&M's and dice. Students collect data for mathematical models and use graphing calculators to make sense of the general form of the exponential functions. (Contains 10 figures and 2 tables.)
indicated that it performed suitably as a witness dye with improved characteristics as compared to methylene blue. Further, the experiments indicated...light output by methylene blue adsorption on post experimentation reactor UV LEDsUV LED Quartz Lens Adsorption Experiment ...31 UV Brilliant Blue FCF...10 Figure 2 - Flow through reactor with UV LEDs
of field components .................................................................... 10 Figure 6. Timeline of EES system’s periods of operation...oxidizing chemical molluscicides (chlorine, chlorine dioxide) • CO2 injection • Anoxia/hypoxia • Biological (predators, parasites, diseases) Some of...The field components were arranged on site as shown in Figure 5. a. Assembling sets of small plates, one each of which was retrieved monthly and
Abou-Sayf, Frank K.; Lau, Wilson
A web-based formula-driven tool has been developed for the purpose of performing two distinct academic department budgeting functions: allocation funding to the department, and budget management by the department. The tool's major features are discussed and its uses demonstrated. The tool's advantages are presented. (Contains 10 figures.)
Background ........................................................................... 10 2.1 Software Layer Architecture... 10 2.2 The Object-Oriented Model of RDT ........................................... 12 3. Sum m ary of Current Knowledge... 10 Figure 2. The Object-Oriented Model of RDT ................................. 13 Figure 3. An example to describe the difference
Sabatka, Z.; Dvorak, L.
This article describes a simple and inexpensive way to create and to verify the parabolic surface of a rotating liquid. The liquid is water. The second part of the article deals with the problem of a boat on the surface of a rotating liquid. (Contains 1 table, 10 figures and 5 footnotes.)
TERMS Optic glomeruli, glomerulus, Nasonia vitripennis, jewel wasp, Drosophila , vinegar fly, Giant Fiber, descending neuron, lobula, visual primitive...5 Figure 4. Optic glomerulus local interneuron in Drosophila . ...................................... 10 Figure 5. Giant fiber descending...studies are being performed on Drosophila , because genetic expression of green fluorescent protein provides identification of cell types in the living
Thomas, Kimberley A.; Bruno, Barbara C.; Achilles, Kate; Sherman, Sarah B.
Understanding coral reefs and the threats they face is an essential precondition in preserving them. This activity helps to educate middle school students about coral biology and the problem of coral bleaching. It will inspire students to participate in marine conservation initiatives. (Contains 10 figures and 3 resources.)
Slape, R J
This report describes the qualification tests presently being used at Pantex Plant, Lawrence Livermore National Laboratory, and Los Alamos National Laboratory that are required by the Department of Energy prior to the approval for an explosive as an Insensitive High Explosive (IHE) material. The acceptance criteria of each test for IHE qualification is also discussed. 5 references, 10 figures.
... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Pribilof Islands Area Habitat Conservation Zone in the Bering Sea 10 Figure 10 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... Habitat Conservation Zone in the Bering Sea ER15NO99.008...
... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Pribilof Islands Area Habitat Conservation Zone in the Bering Sea 10 Figure 10 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... Habitat Conservation Zone in the Bering Sea ER15NO99.008...
... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Pribilof Islands Area Habitat Conservation Zone in the Bering Sea 10 Figure 10 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... Habitat Conservation Zone in the Bering Sea ER15NO99.008...
... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Pribilof Islands Area Habitat Conservation Zone in the Bering Sea 10 Figure 10 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... Habitat Conservation Zone in the Bering Sea ER15NO99.008...
... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Pribilof Islands Area Habitat Conservation Zone in the Bering Sea 10 Figure 10 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... Habitat Conservation Zone in the Bering Sea ER15NO99.008...
Christy, Donna; Lambe, Karen; Payson, Christine; Carnevale, Patricia; Scarpelli, Debra
A whimsical mathematics event for children and adults, derived from Lewis Carroll's Alice's Adventures in Wonderland, was held at the Providence Children's Museum in Rhode Island. NCTM's Standards were the basis of all the activities. (Contains 10 figures and 1 table.)
systems .. ............................. 8 Figure 3 Load vs displacement signals for static and dynamic cases . .................................. 8 Figure...4 Energy vs displacement for static and dynamic cases . .................................. 9 Figure 5 Delamination length vs impact load for static...and dynamic cases ....................... 10 Figure 6 Impact energy vs energy loss behavior for 16-ply graphite/epoxy laminates supported on a 2.8-inch
10 Figure 5. FCC structure of the primary material with two groups of atoms of a secondary material imbedded in the solid. The secondary...material atoms are the red asterisk. ................................................................. 23 Figure 6. FCC structure of the primary material...isotropic FCC structure was converted to a composite material by changing the epsilon or sigma values of selected atomic positions within the cubic
red curves reveal a substantial cold bias in the analyzed NAVGEM stratospheric temperatures in boreal winter, when the Sun disappears at high...mean poleward and downwelling circulation cell that adiabatically warms the stratosphere . The black curves in Figure 6 show the results from a...NAVGEM prediction skill in the upper stratosphere . 10 Figure 7. Zonal-mean temperature increments versus NAVGEM model
Revill, Kathleen Pirog; Tanenhaus, Michael K.; Aslin, Richard N.
Reports an error in "Context and spoken word recognition in a novel lexicon" by Kathleen Pirog Revill, Michael K. Tanenhaus and Richard N. Aslin ("Journal of Experimental Psychology: Learning, Memory, and Cognition," 2008[Sep], Vol 34, 1207-1223). Figure 9 was inadvertently duplicated as Figure 10. Figure 9 in the original article was correct.…
Presents a thorough overview of earthquakes in New Zealand, discussing plate tectonics, seismic measurement, and historical occurrences. Includes 10 figures illustrating such aspects as earthquake distribution, intensity, and fissures in the continental crust. Tabular data includes a list of most destructive earthquakes and descriptive effects…
The Corps of Engineers and Prairie Restoration: Synopsis of the First Corps Prairie Workshop, Follow-up Actions, and Thoughts on the Future of Prairie Restoration and Management on Operational Projects
1 Figure 2. Grass strips and blocks have improved habitat conditions for pheasants and songbirds at...10 Figure 5. Native prairie remnants at Granger Lake, Texas, support a diversity of native grasses and forbs... grasses and forbs. Benefits of prairie restoration efforts noted by Corps personnel included erosion control, sediment management, control of non
Methods are presented for distributing gases throughout the interstices of porous materials and removing volatile substances from the interstices of porous materials. Continuous oscillation of pressures and flows results in increased penetration of the interstices by flowing gases and increased transport of gaseous components out of the interstices. The invention is particularly useful in soil vapor extraction. 10 figures.
McKee, D.W.; Spiro, C.L.; Kosky, P.G.
This invention relates to improved catalysts for carbon and coal gasification and improved processes for catalytic coal gasification for the production of methane. The catalyst is composed of at least two alkali metal salts and a particulate carbonaceous substrate or carrier is used. 10 figures, 2 tables.
AEDC-TR-09-T-13 Plume Visualization of Orion Launch Abort Vehicle Jettison Motors Using Background-Oriented Schlieren...10 FIGURES Figure 1. Launch Abort System Test Article Details ......................................................................... 11...Development Center’s (AEDC) Propulsion Wind Tunnel (PWT) 16T was used to visualize the jettison motor (JM) plumes on a scaled NASA Orion Launch Abort
Jarrett, F.W.; Yoon, Y.K.; Newman, J.G.
The gas studied contains 65% CO/sub 2/, essentially no ethane-plus components, is high in nitrogen and contains recoverable quantities of helium. Pipeline gas, high purity CO/sub 2/, and raw helium were required products. This combination presents some difficulties for both processes. 5 references, 10 figures, 3 tables.
needs of specific tools. One network analytical tool, Adaptive Safety and Monitoring ( ASAM ), matches transactions against a pattern library and manages...the uncertainties of the association. ASAM was extended in the second year of NEMESIS to include multiple model tracking, multiple hypothesis testing...10 Figure 5. ASAM Launcher Interface
as yeast infections and urinary tract infections . They could also test for pregnancy and dispense birth control. The clinics, however, were not...settings, including advice about avoiding urinary tract infections and yeast infections; (3) female-specific health care services available in- theater...Soldiers Deployed to Bosnia had provided information on preventing urinary tract infections and vaginal infections (see fig 1.2). Figure 1.2: Which
the chiral angles of carbon nanotubes. ........................................ 12 Figure 4. Planar diagram of a graphene sheet showing the different...image on the right is at (10× magnification), and is a close up of one fiber bundle showing the fracture of the E-glass...to as the fiber . Many times, the matrix is an epoxy resin, or polyimide, generally referred to as the resin or polymer. At least one of each is
physical cores of aquifer material can be obtained by various drilling methods. These samples can then be tested in a laboratory (i.e., falling or...Figure 2. GEMS location map and aerial photographs. 12 Figure 3. Direct push drilling unit, Electrical Conductance probe, and example...and it is connected to an apparatus attached to the top of the casing at the well (Figure 5). 23 Figure 5a. The pneumatic CPT equipment set up
nearly superimposable with the peptide (12). Figure 11. Examination of the low resolution crystal structures of the 8- lactamase from Bacillus lichenifori...V L L B. licheniformis R F A F A S T I K A L T B. cereus R F A F A S T Y K A L A S. aureus R F A Y A S T S K A I N StreptomycesR61 R F R V G S V I K
This document summarizes work performed at participating sites on the immobilization of high-level wastes from the chemical reprocessing of reactor fuels. The plan is to develop waste form alternatives for each of the three DOE sites (SRP, ICPP, and Hanford). Progress is reported in the following areas: waste preparation; fixation in glass, concrete, tailored ceramics, and coated particles; process and equipment development; and final handling. 12 figures, 19 tables. (DLC)
conduction bands overlap . Figure 6. Generic band gap diagram of a semiconductor (from ). 10 For wide band gap materials the thermal energy...drowning out low-level signals. Since thermal and RF noise are unwanted factors the testing process conducted in this thesis must be approached in...which shows the excessive signal distortion due to thermal noise present during characterization testing
will be marketed to amusement and theme parks and roller coaster designers to ensure that their roller coasters and mechanical rides are safe. By...14 15 Element Model (original and settled positions) 6-12 Figure 6-15 Head Cervical Spine Simulation- 3G Vertical Accelerations 6-13 Figure 7-1...experimentally determined frequency response of humans to vertical excitation and by creating head-spine models for other primates and comparing the model
moving- map , real -time mosaicing, target tracking , and video recording functions. Report No. SERC-2014-TR-036-3... create plug-in software modules for added functionality. In addition, the PCC and ViewPoint allow users to go online and download maps and aerial...environment. .................................................... 12 Figure 4. ViewPoint user interface for streaming video created by the MetaVR scene
Calo, J.M.; Suubers, E.M.; Wojtowicz, M.; Lilly, W.
This project is concerned with the study of the nature and behavior of active sites in gasification of chars produced from synthesized model compounds, primarily of the phenol-formaldehyde family of resins. The current technical progress report presents further developments on resin synthesis and characterization and the design of a pyro-gasifier reactor for transient kinetic studies of the chars produced from the model compounds. 7 references, 12 figures, 2 tables.
up, although the initial vision and goals derive from the top. 12 Figure 1. Los Zetas Organizational Structure -m .__ lione...85 In addition to Tamaulipas, Coahuila, and Nuevo Leon, Los Zetas has also taken over the piracy business in Chiapas, Tabasco, Veracruz and Puebla ...Tabasco, Campeche, Yucatán, Quintana Roo, San Luis Potosí, Chiapas, Puebla , Tlaxcala, Hidalgo, Querétaro, Zacatecas, Durango, Guerrero, Oaxaca
guided software and needle tracking in phantom study......................... 12 Figure 10: Respiratory motion phantom being scanned in Siemens...with phantom studies, then proceeding to animal studies, followed by the ultimate aim of human clinical trials. The project is led by the Imaging...the ISIS Center and shown in Figure 3. An abdominal phantom with precision target points will be used to provide ground truth for the experiments
12 Figure 3. Circular causality of a feedback loop (After Capra , 1996) .............................13 Figure 4. Drawing Hands...management and design ( Capra , 1996). It is through an open systems perspective that this thesis proceeds with its analysis. Taking an open systems...system’s structure and behavior through mechanisms called feedback loops. As explained by Capra a feedback loop is “a circular arrangement of
Participation, Fiscal Years 2009-2011 12 Figure Figure 1: Sample Logic Model 18 Abbreviations 9/11 Act Implementing Recommendations of the 9/11...has previously identified such frameworks, called logic models , that agencies could adopt even if they face performance measurement challenges similar...31A logic model is an evaluation tool used to describe a program’s—or initiative’s, in the case of PSI—components and
Bushmaster gun tubes and swage autofrettaged 120-mm gun tube. ...............12 Figure A-1. Final test fixture configuration; all dimensions in inches...produced during the firing, resulting in liner movement (3). However, swaging a steel jacket over a Stellite rod can produce an acceptable bond in a...gun tube (explosion-bonded at TPL, Inc.) (5), and a 120-mm extended length gun tube ( swage -autofrettaged at Benet Laboratories) (6). The
71 ix LIST OF FIGURES Figure 1. RFT vs. FMC for all 293 Observations including a Loess Smoother with Bandwidth = 0.7...increases, RFT should increase and vice versa. Figure 1 displays a plot of RFT versus FMC including a loess smoother for the 293 wing/month...indefinite positive linear relationship. 12 Figure 1. RFT vs. FMC for all 293 Observations including a Loess Smoother with Bandwidth = 0.7
Rights License 14. ABSTRACT We introduce novel, truly non-ionic hydrogen -bonded layer-by-layer (LbL) coatings for cell surface engineering capable of...Encapsulation 1 Methods of Cell Encapsulation 2 Electrostatic vs. Hydrogen -bonded Shell Performance 10 2 Goals & Objectives 13 3 Methods 14 Layer by...PEI(TA/PVPON)4 hollow shells dried on a silicon wafer 12 Figure 10: Schematic illustrating LbL assembly of hydrogen bonded layers 14
Figure 5. Gyroscopic Stabilization on a Spinning Top [see ref. 8] .................................12 Figure 6. Nutation of a projectile subjected to...flight trajectory as shown in Figure 6. This is commonly known as nutation . The resulting flight trajectory would not be in a straight line; rather it...would precess along its trajectory, as shown in Figure 7. Figure 6. Nutation of a projectile subjected to an initial disturbance [see ref. 8] 13
Experimental Study of the Driving Mechanism and Control of the Unsteady Shock Induced Turbulent Separation in a Mach 5 compression Corner Flow...University of Tokyo, Hongo Bunkyo-ku, Tokyo 113, Japan, Oct. 25-29, 1987. 12 Figure 1. Schematic diagram of the test section with compression...ramp. Seeding System Optics FLOW CCD Cameras Dual-Cavity Nd: Yag Laser Photodiode Beam Splitter Timing Electronics ``` FLC Shutter Controller
2,56)=0.18; SBP: Fcondition(1,2Figure 10. Heart Rate Response to Stroop reactivity to the cold pressor , effects of exercise withdrawal nt with respect...HR response will be important. HR is controlled by both the sympathetic and parasympathetic nervous systems. Heart rate variability ( HRV ) is a...sympathetic and parasympathetic nervous systems plays an important role in cardiovascular homeostasis. Heart rate variability has been used as an
10 1.3.1 Tunable Directional Coupler ...................................................... 11 1.3.2 Wavelength...tunable directional coupler , in which the effective index of each arm is tuned via an adjustable slot width. ……………………... 12 Figure 1-7 Schematic...of photonic circuits that can filter, buffer , and reroute optical signals is expected to transform optical communications , enable high-speed
developing interpersonal relationships, taking risks , persistence, and demonstrating commitment through actions (e.g. “walking the walk”) (Kotter 1990:5...a graphical view. 36 Military 71% Leadership 21% Manageme 8% Figure 3. Analysis of ROTC Cadet Training Courses Officer Training School (OTS... Manageme 12% Figure 4. Analysis of OTS Cadet Training Courses United States Air Force Academy (USAFA) Analysis Applying our methodology to the USAFA
This flood hazard report describes the extent and severity of the flood potential along selected reaches of the Duck and Little Duck Rivers, and Grindstone Hollow, Hunt, Hickory Flat, and Wolf Creeks in the vicinity of Manchester, Tennessee. The report was prepared by TVA as a result of a request from the city of Manchester for TVA technical assistance in evaluating alternative solutions to local flood problems. 5 references, 12 figures, 12 tables.
Availability Codos 3Avd t’l and/or list Special List of Figures Figure 1. Schematic of pervaporation process .................. 2 Figure 2. Schematic...oxygen extraction rate from seawater by pervaporation ....... ....................... 7 Figure 5. Photograph of the experimental set-up for measuring the...12 Figure 9. Pressure drop across pervaporation module as a function of feed water flow rate ................. 13 Figure 10
coordinates. . . . . . 12 Figure 2.3 An illustration of geometric occlusion in generating detections. The red and blue agents (right) block portions of...according to the targets in the environments and uses Gaus- sian and uniform distributions. Both occlusions of the agents and possibilities for false...avoidance where they can cross over each other. Also agents have limited sensor coverage, and the effects of optical target occlusion is approximated in
Merewether, E.A.; Blackmon, P.D.; Webb, J.C.
Stratigraphic data, paleontologic and petrographic information is presented for the Frontier Formation in the Green River Basin of Wyoming, Utah, and Colorado. In addition, interpretations concerning the areal extent and depositional origin of some strata within the formation are presented. Data indicate that most of the sampled shale units are thermally mature, in terms of oil generation, and some are probably source rocks for oil and gas. 12 figures, 11 tables.
dust into the earth’s atmosphere each year ( Barnum , 2003). Dust storms directly effect visibility and impact daily commercial and military operations...MH-53 UH-1 V-22 V-22 Landing 12 Figure 4. Dust threshold surface wind velocity calculated in CARMA ( Barnum , 2003) At the threshold speed...that a forecasted dust 14 concentration of 2500 µg m-3 or greater was sufficient enough to reduce visibilities to less than 2 miles ( Barnum , 2003
figure 4). The apparatus includes a windowed chamber capable of being pressurized up to 10 MPa. It also includes a ballast tank that adds considerably... pressures were acquired, and they can be employed to validate a state-of-the-art CFD model that ARL is developing to accelerate the development of...rates at pressure near 5.18 MPa. ..............................................................12 Figure 11. JA2 burning rates at 6.90 MPa
Society of America.25 If the culture grew coagulase-negative Staphylococcus or common skin flora , the illness was not considered pneumonia. ALI and ARDS...to achieve a urine output of 30 to 50 ml/hr. Albumin (5% in normal saline) was administered during hours 24 to 48 postburn. (It was started 12...Figure 1). The total score for each slice was then summed for the entire Table 1. RADS scoring Finding Score Normal 0 Increased interstitial markings
channel associated with discharge events. (Note: There may be aggradation or degradation after step 2. ) 14 ERDC/CRREL TR-08-12 Figure 11. Pre...overbank flows emanating from aggrading main channel 16 ERDC/CRREL TR-08-12 Single-thread channels with adjacent floodplains – Meandering...relative to sediment supplied to reach – Channel widening with bank destabilization – Aggradation due to decrease in capacity to transport sediment
down time, refer to 4.3.6 of the test method. 12 Figure 1. GMW 14872 (7) cycle description. Actual or simulated steel components shall be used for...including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing...SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited. 13
McLennan, Michael K.; Marotta, Thomas R.; TerBrugge, Karel G.; Marotta, Joseph T.
The family physician is often called upon to diagnose a range of adult neurologic disorders. Clinical history, physical examination, laboratory tests, and imaging studies are required to discover their cause. Various imaging modalities can be used to evaluate common adult disorders of the central nervous system. ImagesFigures 1-2Figure 3Figure 4Figures 5-6Figures 7-8Figures 9-11 PMID:21229013
block………………………………………………………………………….11 Figure 11. Strouhal number of the screech frequency versus fully expanded jet Mach number as predicted by the...cell spacing LES – Large Eddy Simulation Md – Design Mach Number Mj – Mach number of a fully expanded jet Mic – microphone NPR – Nozzle...geometry mechanism used on tactical military jets currently in the field. The four nozzles have design Mach numbers (MD) of 1.0, 1.3, 1.5 and 1.65. The
Since two 00 transitions are observed, 8 has two stable conformations in the ground state. CH 2OH CH2CH3 C. 4-, 3-, and 2- Methylbenzyl alcohols (9-11...The TOFMS of 9-11 are presented in Figures 4a, 4b, and 4c respectively. 4- Methylbenzyl alcohol (9) has the same symmetry group as 1 and thus only...NII 9 10 11 Figure 4b depicts the TOFMS of jet-cooled 3- methylbenzyl alcohol (10) around the origin of the S 1+ S0 transition. The symmetry group of
2.4 GHz WiFi hotspot. ........................ 11 Figure 12: Detail of the MikroTik router board (Copyright © Mikrotikls Ltd, 2000−2006). ....... 12...12 – Detail of the MikroTik router board (Copyright © Mikrotikls Ltd, 2000−2006). Details of the router board are shown in Figure 12 with three RF...slots. The board manufacturer is Mikrotik , model RB433AH Router. It was chosen due to its characteristics which comprise: • MIPS-based AR7100
dispersed ice field, J. Fluid Mech., 202, 43-81. Mei, C.C. and Liu, K.-F., 1987: A Bingham - plastic model for a muddy seabed under long waves. J...Implementation and Testing of Ice and Mud Source Functions in WAVEWATCH III® W. Erick rogErs Mark D. orzEch Ocean Dynamics and Prediction Branch Oceanography...11 Figure 6. Final state of the second two-dimensional test case, as explained in the text. .............. 13 Figure 7. Comparison of WW3- predicted
Adolf, D.B.; Shahinpoor, M.; Segalman, D.J.; Witkowski, W.R.
Electrically controlled polymeric gel actuators or synthetic muscles are described capable of undergoing substantial expansion and contraction when subjected to changing pH environments, temperature, or solvent. The actuators employ compliant containers for the gels and their solvents. The gels employed may be cylindrical electromechanical gel fibers such as polyacrylamide fibers or a mixture of poly vinyl alcohol-polyacrylic acid arranged in a parallel aggregate and contained in an electrolytic solvent bath such as salt water. The invention includes smart, electrically activated devices exploiting this phenomenon. These devices are capable of being manipulated via active computer control as large displacement actuators for use in adaptive structure such as robots. 11 figures.
following the end of the Cold War and determined the necessary mixture of active duty and reserve soldiers to meet the Army’s strategic objectives...0.15 0.2 0.25 4 5 6 7 8 9 10 11 12 13 14 15 Pe rc en ta ge of R an k Years Officer Seperation Rate over Planning Horizon Rank 7 Rank 8 Rank 9 Rank 10...15 Pe rc en ta ge of R an k Years Officer Seperation Rate over Planning Horizon Rank 7 Rank 8 Rank 9 Rank 10 Rank 11 Figure 11. Scenario 2
AISI C1020 steel casings, and plastic-cased mines with rigid PVC casings. A unit area of 1cm2 is considered so that the calculations may be scaled to...J/m3/C] 2.00E+06 Steel PVC Thickness [mm] 2 5 Density [kg/m3] 7850 1460 Mass [kg] 1.57E-05 7.30E-06 Thermal Conductivity [W/m.K] 51.9 0.0313...TNT (333 oC) Melting Point of PVC casing (90 oC) DRDC Suffield TR 2006-050 11 Figure 6. Temperature Distribution in the Casing for an
M- .31 »t. Aula CraHtaa C • ’.• II • .11 Figure 31 NYQUIST PLOTS WITH YAW LOOP CLOSED FIRST, M=0.9, 20,000 FT, MISSILES-OFF, FLEXIBLE...MMMiMMii ttHlMWB MM« i.-li.rt.ni-l - ■ mmmwrn. mmmmß The 5 DOF and 9 DOF system analyses in this section have virtually the same negative axis...loop, in the zero to 10 Hz frequency range, should be virtually the same for the 5 and 9 DOF systems. The lateral acceleration and yaw rate per
Albrecht, G.F.; Comaskey, B.; Sutton, S.B.
The architecture of the present invention has been driven by the need to solve the beam quality problems inherent in Brewster's angle tipped slab lasers. The entrance and exit faces of a solid state slab laser are cut perpendicular with respect to the pump face, thus intrinsically eliminating distortion caused by the unpumped Brewster's angled faces. For a given zigzag angle, the residual distortions inherent in the remaining unpumped or lightly pumped ends may be reduced further by tailoring the pump intensity at these ends. 11 figures.
Gerald Smith with the Department el, 9; r II> ,, 0 cr- Il ’aaI Il L11/ Figure 2. Areas Which Have Been Surveyed. (From Smzith 1979:127). 3 of...4OCt.18 Unkno;ýi prehistoric ŘOCt19 Unknown prehistoric 40Ct25 Unknown prehistoric Dyer County 40Dy13 Unknown prehistoric 40Dy16 Archaic R Unknown...Woodland 40Gb121 Historic (1870-1955) Haywood County None Lauderdale County R Unknown prehistoric Madison County None Obion County 40Ob-A Possibly Archaic
Nelson, D.A.; Tomich, S.D.; Glover, D.W.; Allen, E.V.; Hales, J.M.; Dana, M.T.
The present invention constitutes a rain sampling device adapted for independent operation at locations remote from the user which allows rainfall to be sampled in accordance with any schedule desired by the user. The rain sampling device includes a mechanism for directing wet precipitation into a chamber, a chamber for temporarily holding the precipitation during the process of collection, a valve mechanism for controllably releasing samples of the precipitation from the chamber, a means for distributing the samples released from the holding chamber into vessels adapted for permanently retaining these samples, and an electrical mechanism for regulating the operation of the device. 11 figures.
Recent membrane developments for gaseous mixture separations are compared to the development of reverse osmosis membranes for water desalination. The goals of these developments have been the search for ideal permselective polymeric materials, techniques for producing ultrathin membrane layers free of imperfections and transforming gelled reverse osmosis membranes into solid gas permeation membranes. A novel approach to meeting the basic requirements of high permselectivity is attempted by altering the physical polymer structure within the membrane prior to application for gas separation. The influence of these physical interactions on membrane properties is presented. 47 references, 11 figures, 6 tables.
Passive Acoustic Detection and Localization of Mesoplodon Densirostris (Blainville’s Beaked Whale) Vocalization Using Distributed Bottom-Mounted Hydrophones in Conjunction With a Digital Tag (DTAG) Recording
éventail de référence situé dans la Langue de l’océan, Bahamas. Deux détecteurs, une transformation rapide de Fourier (FFT) basée détecteur et filtre ... filtre adapté est la plus performante, ce qui permet à 92% des animaux marqués de clics pour être détectés sur au moins un des hydrophones. Time...to time-synchronized 3D localizations by adjusting the swim speed to a least-squares match (Figure 11). Figure 10: Original DTag Kalman -filtered
A sudden excitation event of the Chandler wobble should induce the earth's rotation pole to undergo damped harmonic motion. This type of motion has been searched for in the observations of the Chandler wobble using techniques based upon the concept of a matched filter. Although the signal detection techniques used here were not sensitive enough to detect any such isolated sudden excitation events; the result that was obtained is consistent with a randomly excited model of the Chandler wobble. 16 references, 11 figures, 1 table.
Besides EDTA and cysteine, cystine and penicillamine are the best collagenase inhibitors. The collagenase is produced by the leucocytes. The action mechanism of the collagenase inhibitors is due to the chelation of Zn ions. The best clinical indications for collagenase inhibitors are punctate epithelial keratitis, chemical burns, recurrent corneal erosions in keratoconus, trophic postinfectious ulcerations of the cornea (metaherpetic ulcers), and descemetoceles. Images FIGURE 6 A FIGURE 6 B FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 4 A FIGURE 4 B FIGURE 4 C FIGURE 7 A FIGURE 7 B FIGURE 9 FIGURE 10 A FIGURE 10 B FIGURE 11 FIGURE 12 A FIGURE 12 B PMID:206998
6900 7400 7900 8400 8900 1 6 11 16 21 26 31 36 41 46 51 56 61 66 71 76 81 86 91 96 TS Iteration M is si on E va lu at io n Figure 9: Caribbean...on E va lu at io n Tenure 7 Tenure 9 Tenure 11 Figure 10: Tenure Comparison for Cuba Scenario Tenure 7 and 9 reach many of the same solution...6900 7400 7900 8400 8900 1 7 13 19 25 31 37 43 49 55 61 67 73 79 85 91 97 TS Iteration M is si on E va lu at io n 2 Large 1 Small 2 Small 1 Large
the three terminal voltages ( VSG , VGG, and VDG). The results of these measurements are shown in Figs. 9-11. Figure 9 shows how frequency and terminal...currents depend upon source-to-gate voltage. Note that the frequency ranges from 12.7 to 14.7 GHz as VSG is varied 5 from 5.0 to 6.1 V. Oscillations are...not observed for VSG below 4.5 V or above 6 V. The dramatic decrease of source current and increase of gate-1 current for VSG greater than 7 V is due
REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...3) shown by the solid blue line, using path e shown by the solid red line and path d shown by the dashed green line. 11 Figure 8: The beam time...solid blue line), path e (solid red line) and path d (dashed green line). These are target strength measurements from a single mud volcano and they
Kustom, R.L.; Fuja, R.E.
In an inductor-convertor circuit for transferring electrical energy between a storage coil and a load coil through a storage thyristor bridge, a load thyristor bridge, and a set of commutating capacitors, operation is improved by a method of changing the rate of delivery of energy in a given direction. The change in rate corresponds to a predetermined change in phase angle between the load bridge and the storage bridge, and comprises changing the phase of the bridge by two steps, each equal to half the predetermined change and occurring 180/sup 0/ apart. The method assures commutation and minimizes imbalances that lead otherwise to overvoltages. 11 figures.
Makowiecki, D.M.; McKernan, M.A.
An improved method and assembly for attaching sputtering targets to cathode assemblies of sputtering systems which includes a magnetically permeable material is described. The magnetically permeable material is imbedded in a target base that is brazed, welded, or soldered to the sputter target, or is mechanically retained in the target material. Target attachment to the cathode is achieved by virtue of the permanent magnets and/or the pole pieces in the cathode assembly that create magnetic flux lines adjacent to the backing plate, which strongly attract the magnetically permeable material in the target assembly. 11 figures.
and Experimental Pressure Distributions on a Circular Cylinder; Re =8.4 x 106. 21 S., -10 Co EXPERIMENT - CALCULATIONS, TRANMAX -5 0 10 Figure 18...theoretical and experimental study of the flow over a prolate spheroid is being investigated at t l- DFVLR. The first experiments were aimed at the...PRESSURE TAP regime in which experimental data are very scarce. 1I. Description of the Experiments 1.4500 0 0 Facility 0 The tests were conducted in the
allows the coupling of both SPPs and LSPRs via geometry partial metal shell and self aligned metal nanohole b) Calculated external quantum efficiency of...the NOA as a function of pitch of the self-aligned nanohole lattice ....................... 10 Figure 3: a) FDTD simulations of the power absorption...showing the signal contact aligned to the nanopillar array. ..................... 16 Figure 6:a) High resolution SEM of the nanopillar in the nanohole
Hanson, R. J.
A package of FORTRAN codes has been developed for certain multiple precision integer operations. These operations include basic arithmetic, modular exponentiation, and conversion of numbers to and from decimal representation. Reliability of the results is maintained by cross-checking both the lengths of internal working storage arrays against the requirements of the operations, and the size and sign of the internal representation of the digits. 10 figures.
Apparatus is described for separating material into first and second portions according to size including a plurality of shafts, a plurality of spaced disks radiating outwardly from each of the shafts to define apertures and linkage interconnecting the shafts for moving the shafts toward or away from one another to vary the size of the apertures while the apparatus is performing the separating function. 10 figures.
emotional support provided by family/friends. Further work is in progress to identify BRCA1 gene mutations in women with affected relatives with breast...10 Figures Figure 1. Schematic Diagram of the BRCA2 Gene ............................................ 13 Figure 2A. Family...polymorphic variants in these genes in at-risk African American women. The results of these first studies conducted in three families indicated that
shockwave ........................ 10 Figure 5. Stress-density data fit for gray granodiorite ........... 15 Figure 6. Stress-density data fit for NTS...types were dry NTS tuff, gray granodiorite , and limestone,  and . The data obtained in Ref.  were obtained from high pressure die assemblies...The results are shown in Figures 5 - 7. The data fit analysis for granodiorite resulted in two curves passing through the data points. The first curve
1. Urban population (% of total population) (From The World Bank 2013). ........2 Figure 2. Projected urban population in year 2050 (From UNICEF...4 Figure 4. Dragonfly Innovation Inc’s Dragonflyer X4-ES (From Saskatoon 2012).......10 Figure 5...urbanization continues to change the face of the world , the likelihood of having to deal with an urban emergency increases. According to The World Bank
8. PERFORMING ORGANIZATION REPORT NUMBER ARL-TR-4784 10 . SPONSOR/MONITOR’S ACRONYM(S) 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES...acquisition technique. ...................................8 Figure 10 . The SIRE transmitting pulse in the time-domain and frequency-domain... 10 Figure 11. False color plot of one complete frame of radar data: 16 receiving records using the left transmitter and 16 receiving
Nieves, L.A.; Moe, R.J.
Five models were developed to forecast future Chesapeake seafood product prices, harvest quantities, and resulting income. Annual econometric models are documented for oysters, hard and soft blue crabs, and hard and soft clams. To the degree that data permit, these models represent demand and supply at the retail, wholesale, and harvest levels. The resulting models have broad applications in environmental policy issues and regulatory analyses for the Chesapeake Bay. 37 references, 10 figures, 99 tables.
from DLA-E, 2011).....10 Figure 8. Pathways for Biomass to Liquid Fuels Production (From Gorin, 2010) ........23 Figure 9. Simplified Process...edible biomass grown on marginal lands and coastal waters. Some are produced using coal to liquid technology. These may be the fuels of the future...liquefaction process Renewable oils from biomass , and Alcohols from fermentation of biomass (Hileman et al., 2009, p. 11) The report
processing structure developed under the REVEAL project 4 Figure 4: Performance of the REVEAL Likelihood Ratio processor under Gaussian noise and for...Figure 6: Likelihood ratio test constructed by point-wake dividing the kernel density estimates 9 Figure 7: Receiver Operating Characteristic (ROC...curves for a detector like that shown in Fig. 6. . 10 Figure 9: Receiver Operating Characteristic (ROC) curves for likelihood ratio receivers applied
Technical Report Documentation Page 1. Report No. 2. Government Accession No. 3 . Recipient’s Catalog No. DOT/FAA/RD-90/16 4. Title and Subtitle 5...Introduction ........................................... 1 2.0 Analysis Approach .................................. 3 3.0 Correlation of Flight Test Data with...9 Figure 3 Examples of Bell XV-15 Mean and Peak Outwash Velocity Profiles in a Zero Wind Hover ....... 10 Figure 4 Three-View Drawing of the
Research (CAVR) . . . . . . . . 9 Figure 2.2 The regions of space observed by an ultrasonic sensor. From:  . . . 10 Figure 2.3 Obstacle Represented in...and presented by . . Figure 2.2: The regions of space observed by an ultrasonic sensor. From:  A model for the occupancy of cells in a grid is...manage than conventional helicopters. Another advantage of using quadrotor design is that they are typically motorized by batteries 17 instead of a
alpha amylase and cortisol were collected; blood pressure and heart rate were also recorded. Sample: A convenience sample of 38 Army Nurses from... amylase and cortisol were collected; blood pressure and heart rate were also recorded. Sample: A convenience sample of 38 Army Nurses from Madigan...Principal Investigator (McGraw, Leigh Kyle) USU Project Number: N09-P10 Figure 2 Cortisol and salivary α- amylase (sAA) [transformed] in response to
reporting period as seen in Figure 8. The internal lab 3D printer will be used to build the concepts for form and layout testing in the next reporting...using the lab 3D printer seen in Figures 6-7. This concept will be delivered to the customer as a precursor to the functional prototype at the ONR...10 Figure 4: 3D drawings for wrist unit
speed version. Results. Figure 4 is a plot of the Ankudinov bow Sb (SbA) and stern Ss (SsA) squat predictions for the modified Bunga Saga Emphat... speeds AnkudMOut.out. ERDC/CHL CHETN-IX-19 August 2009 10 Figure 4. Ankudinov bow and stern squat predictions for modified Bunga Saga Emphat Panamax... speed increased, but not as much as the bow predictions . Bow predic- tions are generally better (closer to PIANC predictions ) than the stern
Barrick, C.W.; Clarke, S.M.; Nordin, C.W.
An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabilizing the non-protein antigens with detection levels for antibodies specific to the antigens on a nanogram level. A screening assay with the apparatus allows for early detection of exposure to non-protein materials. Specifically metallic elements are detected. 10 figures.
Buying Power 1.0 Figure 2. Better Buying Power 2.0 Figure 3. Better Buying Power 3.0 179 Figure 4. Contract Cost Growth on Highest Risk (Major...Crossing Critical Congressional Cost- Growth Thresholds iv Getting Defense Acquisition Right 67 96 97 184 Table 1. Root...Causes for Major Programs Crossing Critical Con gressional Cost- Growth Thresholds or Other Major Problems 185 Figure 8. Planned Length of Active
Padilla, A. Jr.; Martin, F.J.; Niccoli, L.G.
Parametric analyses using the SIMMER code were performed to evaluate the potential for a severe recriticality from a pressure-driven recompaction caused by an energetic FCI during the transition phase of a hypothetical accident in a fast reactor. For realistic and reasonable estimates for the assumed accident conditions, a severe recriticality was not predicted. The conditions under which a severe recriticality would be obtained or averted were identified. 10 figures, 2 tables.
the He cryostat.... 10 Figure 7. Van der Pauw sample geometry and connections: a) basic electrical circuit for measuring sample resistivity; b) high...dictated by the Van der Pauw method ............................ 20 v viv vl0 ABSTRACT 4 he following report describes experiments performed on a molecular...function of sample and electrode geometry, a four-probe method was used, based on a technique described by Van der Pauw .3 The method consists of
epithelium , stroma, as well as immune system, and the fixed nature of the prostate model with expression of the large T antigen, which may have...prostate cancer glandular architecture formed (Figure 10). Figure 10. Subcutanous TRAMP Model to Recapitulate Prostate Cancer. TRAMP C2 cells...specifically modulate the TLR signaling pathway in prostate epithelium , stroma, and immune system. To parse out the role of TLR signaling in
Cup -style anemometer ............................................................................................................. 10 Figure 10...the wind speed in the flume. A cup -style anemometer (Figure 9) was installed near the air intake, and a hot-wire anemometer was installed over the...reef flat. The cup anemometer was an Oregon Scientific Electronic Weather Station Model WM918 with an adver- tised accuracy of 0.18 m/sec or 0.4 mph
MENUS EDITORS ACTIONS <D> Data Set < C > Configuration <X> Execute Specification Editor SBEACH Menu <P> Initial Profile ɘ> Quit < G > Graph Menu Editor...Execute SBEACH "< G > Graph Menu "< 0 > DOS Operations Menu "< Q > Quit (Exit to DOS) Enter Choice - DATA SET: EX_1 10 Figure 3. Main menu Chapter 2
10 Figure 8. RPG -7 radiance image ... imaging infrared, to detect and home in on targets. – BAT (Brilliant Anti-Tank) is an acoustic and infrared guided submunition that searches, tracks and...CO2 2.056×10−1 H2 2.076×10−1 14 DRDC Valcartier TM 2004–356 Figure 8. A radiance image from the RPG -7, the image is 0.4 m wide and 0.2 m high. DRDC
generation of dropsonde, the Yankee, Inc HDSS and XDD sonde was intercompared during CIRPAS Twin Otter test flights on 24-25 June, 2011 with NCAR-EOL...maxima found in the air- sea boundary layer. Figure 6. 150 mb outflow jet observed by AV-6 Global Hawk dropsondes (left) during flight over...data from over 200 km away. 10 Figure 10. Comparison of smoothed XDD infrared SST profile with smoothed Twin Otter Infrared Radiation
through a Michelson interferometer and generated a double pulse as shown in Figure 10. Figure 10. Experimental setup for testing and calibrating...Measuring the Free Spectral Range of the VIPA etalons Using the spectral fringes generated by the Michelson interferometer , we can quantify the spectral...Testing the FROG To test the FROG, we again used use the double pulse from a Michelson interferometer , which yields a FROG trace unlikely to occur by
the AlGaAs layers on the carrier transport properties , the n-i-p structures should be regrown on p-type GaAs substrates rather than beryllium (Be...thermoelectric power generation, enabling full diurnal operation. This report discusses measurements of the properties and efficiency of a...10 Figure 10. I-V characteristics of solar cells with and without an AlGaAs layer (left) a p-i-n
transtibial amputees at Arizona State University. A second subject has been recruited and a new socket has been manufactured. The second subject...Spring Loaded Inverted Pendulum model) works very well for walking. In the past, it was shown to work for running . 10 Figure 1: Normal...The refined SPARKy design uses the RE40 motor, roller screw robotic tendon and FS3000 keel. • Total Weight: 5 lbs not including socket • Box
fact that no production of infectious virus or CPE can be observed does not necessarily mean that no viral specific macromolecular synthesis occurs in...Res, TG and CP MO within 6 hr after HSV-1 infection (Table 10) (Figures 4 and 5). However, there is no evidence of vira] DNA synthesis as evidenced...by measuring production of viral DNA (18) or production of the late protein glycoprotein C which requires DNA synthesis (unpublished observations
speakers behind test subject ... 10 Figure 8. Male subject in REAT facility...Earphone Element Earphone elements (also known as speakers ) provide voice communication and aural warnings within high-noise conditions, at either...collection Artificial Ear Brüel & Kjær type 4153 Used for ear muff type collection Circuit Board Hold Fixture n/a Used to hold speakers for open air
two experiments to date, configurations (A) and (B), show that there is a significant difference in thermal and isobaric properties between the two...configuration (A) setup discovered non- isothermal and non- isobaric behavior in the HCF which resulted in increased cycle time constants. 10 Figure...RM) that resets the engine for the next cycle • Investigate impacts of non- isothermal conditions associated with the engine • Assess time
or 9), although these compounds still showed anti-DHT effects (lanes 2 vs. 6, 8, or 10). Figure 4 . The effects of DHEA derivatives on PSA...2009 - 30 JUN 2010 4 . TITLE AND SUBTITLE Dehydroepiandrosterone Derivatives as Potent Antiandrogens 5a. CONTRACT NUMBER with Marginal Agonist...words) We hypothesized that dehydroepiandrosterone ( DHEA ) metabolites or their synthetic derivatives are able to bind to the androgen receptor with
more hardware than addition. The first two numbers for a sequence from a Fibonacci generator must be supplied and generally m is usually chosen as...congruential generator with a lagged Fibonacci generator. The two generators should produce a good random sequence and tested to make sure the resulting...9 Figure 3 Von Neumann and Xor Corrector for Unbiasing Random Sequences ............. 10 Figure 4 Four Bit Linear
success. However, the Services do not generally measure strength as part of their physical fitness testing, because of issues of safety, and desires to...10 Figure 3. Relationships between lifting capacity to knuckle height and elbow height and ILM, FFM and body m ass...of the Department of Defense (DoD) is "that individual Service members possess the cardiorespiratory endurance, muscular strength and endurance, and
visual system extract motion information dimension x and in time t. This model is one dimensional; from the pattern of light entering the eye? The Hassen...Information 10 Figure 3. about here These results strongly suggest that the human visual system can extract the mean speed of a stimulus composed of many...calculating the mean speed. By this reasoning, the most reliable piece of information that can be extracted when presented with a distribution of speeds is the
previous year. Stripping allowed quick access to a cemented manganese | stratum which effectively sealed the Early Archaic component beneath it. A...I investigators (IV; Bense 1982: Chapter 10, * Figure 10.6), and judged to contain the sealed , intact early Archaic cultural deposits. During the...phase. Feature 4: a historic trash dumping area near what had been the southwest area of the ’old house. Mixed in with plastic, glass , nails, crockery
5 Figure 2. Plasma Density L Dependance ...... ......... 7 Figure 3. Plasmapause Magnetic Activity Dependance . . 8 Figure 4. Plasma Density L... Dependance - Normalized . . 10 Figure 5. The Dusk Bulge . . . .............. 13 Figure 6. Magnetosphere’s Electric and Magnetic Fields 14 Figure 7...1970). 6 -. ~ .ZJ.:AUGUST 12,1968 . -. ----- OUTBOUND PASS - 2 3 4 5 ___ ... 7....9 L Figure 2. Plasma Density L Dependance 7 0D3 #n /2 OUT JND tN
focuses on the dairy farms and the first and second processing levels (from NCFPD, 2011...10 Figure 2. Abstraction of the bulk milk process flow with a transportation network. Our abstraction focuses on the dairy farms , first...period that could be cause by a natural disaster. In our model, we create a network that approximates the flow of milk starting at the dairy farms
endless stairs showed that there were strong effects of the Mifiller-Lyer drawn by the Dutch graphist M.C. Escher on the illusion on grasping as well...complete description of this experiment see .) Figure 5: Illusion of the Proprioceptive Sense. Results Segment 1 - real maximum displacement of the...In other flux in a pseudo-haptic system and a haptic one. In the terms, it implies an illusion of their proprioceptive sense, case of a classical
A dosimeter and probe for measuring exposure to chemical and biological compounds is disclosed. The dosimeter or probe includes a collector which may be analyzed by surface-enhanced Raman spectroscopy. The collector comprises a surface-enhanced Raman scattering-active material having a coating applied thereto to improve the adsorption properties of the collector. The collector may also be used in automated sequential devices, in probe array devices. 10 figures.
resource operational forces examines how externally imposed reductions in Army end strength and related force structure changes drive demand and...Further clarification of planned force structure changes by HQDA, announced after the completion of vignettes 1 and 2, were also incorporated. It...10 Figure 5. New Supply (MOS 19K30E6K4 – Tank Crew) Vignette 4 applies the same force structure changes made for Vignette 3 but applies the
9 Figure 8: pathChirp provides accurate estimate of bandwidth on CAIDA Gigabit testbed..............10 Figure 9...track changes in available bandwidth on the CAIDA Gigabit testbed; observe how the pathChirp estimate rises and falls in proportion to the...Figure 8: pathChirp provides accurate estimate of bandwidth on CAIDA Gigabit testbed Our second edge-based probing tool, STAB (for
Ebert 2013). Posture and position data were recorded for male and female enlisted personnel at three Army posts as they sat in a driver mockup ...Figure 1). Figure 1. Driver and squad mockups . The current study used data from 145 men and women tested in the driver mockup . Table 1 lists...UNCLASSIFIED 10 Figure 2 shows the garb levels used for measurements in the mockup . At the Advanced Combat Uniform (ACU) level, Soldiers wore their own
male and female enlisted personnel at three Army posts as they sat in a squad mockup (Figure 1). Figure 1. Squad mockup . The current study...used data from 144 men and women tested in the squad mockup . Table 1 lists summary statistics for standard anthropometric variables for the combined...unlimited 10 Figure 2 shows the ensemble levels used for measurements in the mockup . At the Advanced Combat Uniform (ACU) level, Soldiers wore
CART ) analysis organizes the data in a format more useful for decision making. CART analysis classifies data at multiple hierarchal levels. The best...5 50% TOGW < 25 klbs S = 7 25% Morph S = 6 12% No Morph S = 8 12% Morph S = 16 12% No Morph S = 23 12% Figure 6. CART Analysis Based for # of...Sorties Based on Gross Weight and Morphing When CART is applied to the hunter-killer sortie data, gross weight is by far the most important effect; the
the remaining part of the wind tunnel (nozzle, test section, and vacuum tank ) is evacuated by vacuum pumps to a pressure of ~10–2 mmHg. During the...diaphragm 3; 4 – plunger; 5 – pressure multiplier; 6 – two-step piston; 7 – damping fluid; 8 – tank for fluid; 9 – controller of the flow rate; 10...8, the pressure in the fuel tank was maintained constant, and the air-to-fuel ratio was α = 0.7–1.2. Figure 4 shows an example of static pressure
Chapter 7 from e-book, Topics on the Pathology of Protozoan and Invasive Arthropod Diseases. 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY... proTozoan and invasive arThropod diseases Figure 7.2 Whole mount of dividing Trichmonas vaginalis trophozoite from culture. Note 2 sets of anterior... proTozoan and invasive arThropod diseases 7.9 7.10 7.11 7.12 Figure 7.6 Acute inflammatory cells aggregating around epithelial cell at right (cannonball
This report presents the findings of the Minnesota Peat Inventory Project's (MPIP) reconnaissance-level survey of an area of Beltrami and Lake of the Woods counties. Peatlands cover about 314,000 hectares (775,000 acres) of this area and constitute about 12 percent of the state's total peat resource. The survey identifies the location and amount of fuel-grade and horticultural peat in the two county area. The report provides a general discussion of peatlands and describes the field and laboratory procedures of this peatland survey and presents a map of the peat resources in the surveyed area. 28 references, 12 figures, 12 tables.
Barker, C.E.; Eimerl, D.; Velsko, S.P.; Roberts, D.
Temperature-insensitive, phase-matched harmonic frequency conversion of laser light at a preferred wavelength of 1.064 microns can be achieved by use of a crystal of deuterated l-arginine phosphate. The crystal is cut and oriented so that the laser light propagates inside the crystal along one of several required directions, which correspond to a temperature-insensitive, phase-matching locus. The method of measuring and calculating the temperature-insensitive, phase-matching angles can be extended to other fundamental wavelengths and other crystal compositions. 12 figures.
Popescu-Marinescu, V.; Elain-Talau, L.; Papadopol, M.; Nicolescu, D.; Teodorescu, L.
Research on the effects of geothermal waters (both used and unused) on vertebrates and invertebrates made the water's toxico-lethal character obvious in waters with a normal concentration or diluted up to over 17%. Among the organisms used in the experiment, Daphnia magna (a cladoceran) and young carp (Cyprinus carpio) have proved to be more sensitive. Tubifex tubifex (an oligochaete) have proved to be more resistant. Taking in account the toxicity of geothermal waters with addition of a specific smell and taste contracted by the meat fish, their overflow into natural receivers is not recommended. 7 references, 12 figures.
Hung, Feng-Jung Huang, Kihong Kim, Hyun Yoon, Yochuol Ho, Namkyu Park, Narasimhan Trichy Rajagopal, Saket Bhatia, Seong-Mo Yim, Dong-Jun Yang, Xiaoling ...measured noise figure is the same as that in Chiu and Lu , and the gain is 5-dB higher than that in Chiu and Lu . Additionally, 108Table 7-1...0.0 10.0 20.0 S -p ar am et er s (d B ) S21 S22 S11 S12 Figure 7-3 Measured 5-GHz LNA S-parameters 109the LNA in Chiu and Lu  requires a special
Larue, D.K.; Martinez, P.A.
Based on a combination of Walther's Law of Facies and bed-form climb theory, the authors propose a model that explains how erosion surfaces and vertical sequences of clastic strata are preserved where deposition occurs in channelized or locally erosional environments including fluvial and submarine-channel deposits, barred beaches, and transgressive coastlines. the model considers both lateral and vertical migration of a scour surface and its associated depositional products. As in studies of bed-form climb, they recognize subcritical, critical, and supercritical climb of scour surfaces relative to adjacent depositional forms. 12 figures.
Burry, D.B.; Williams, P.M.
A system and method for exchanging tools and end effectors on a robot permits exchange during a programmed task. The exchange mechanism is located off the robot, thus reducing the mass of the robot arm and permitting smaller robots to perform designated tasks. A simple spring/collet mechanism mounted on the robot is used which permits the engagement and disengagement of the tool or end effector without the need for a rotational orientation of the tool to the end effector/collet interface. As the tool changing system is not located on the robot arm no umbilical cords are located on robot. 12 figures.
Figure 6-4. Compressive wiring connecting a die to a printed circuit board 6-12 Figure 6-5. Single glob-topped die mounted directly on a printed ...two minutes 6-54 Figure 6-31. MMS MCM test package before MEMS release etch processing 6-60 Figure 6-32. LCD watch printed circuit board rebuilt...95J-02, June 1995. 36 G. Fuhr, R. Hagedorn, T. Müller, W. Benecke and B. Wagner, "Microfabricated electrohydrodynamic (EHD) pumps for liquids of
encountered, Figure 2.1 illustrates the roll over angle computation method . 12 Figure 2.1 Static Roll Over Angle 3. Ground Resonance As shown by Coleman... method . TABLE 4.1 VON MISES FAILURE CRITERION X/L STRINGER %YIELD STRESS X/L STRINGER %YIELD STRESS PT. PT. 0.00 1 8.12% 0.50 5 8.12% 0.00 2 89.63...Measurements Group. Inst Div Raleigh, NC Calibrated June 18, 1986 P-3500 Strain Indicator Calibrated July 7, 1986 BAM Is (Two of them) Serial Numbers
between estimated and experimentally derived 0 (298)f gH∆ values. ..........12 Figure 4. Differences between G2-ae, G2- ir , and DFT estimates...kcal/mol). ....11 Table 2. Comparison of RPH AE, G2-ae, G2- ir , and DFT 0 (298)f gH∆ estimates (kcal/mol).......13 Table 3. Comparison of ZPVEs...298(0Hr∆ ] for “isodesmic reactions” and will be referred to as the “G2- ir ” method. [Isodesmic reactions are reactions in which the total number of
Negm, Y.; Zimmerman, G.O.; Powers, R.E. Jr.; McConeghy, R.J.; Kaplan, A.
A composite lead is provided which electrically links and conducts a current between about 75-80K and liquid helium temperature of about 4.5K. The composite lead may be employed singly or in multiples concurrently to provide conduction of electrical current from normal conductors and semi-conductors at room temperature to superconductors operating at 4.5K. In addition, a variety of organizational arrangements and assemblies are provided by which the mechanical strength and electrical reliability of the composite lead is maintained. 12 figures.
efficacy None -- < 2 - 2-4 4-6 S6-8 -e- 8 -10 -A 10-12 --- > 12 Figure O.17.d Profile Plot for PRIORE 0-88 Biblio.0.ahy. Bandura , Albert . "Self-Efficacy...34 Psychological Review, 84. 191-215 (1977). Bandura , Albert and Richard H. Walters. "Principles of Social Learning," Social Learning and Personality Development...Force Manual 50-62 (1984:20-21), is based on evaluating learned behavior that can be seen, heard, or otherwise sensed. However, Bandura (1977:191-193
2 Figure 1.2 From , an example of a body joint . . . . . . . . . . . . . . . . . . . 2 Figure 1.3 From , Agbot...body joint capable of changing the location of its center of mass was discovered and implemented into the design of many of the Wheg-mobile platforms...An example is shown in Figure 1.2. Figure 1.2: From , an example of a body joint . 2 Prior to 2009, the Wheg-mobile robots designed by Case Western
Tactile Displays for Orientation, Navigation and Communication in Air, Sea and Land Environments (Les systemes d’affichage tactiles pour l’orientation, la navigation et la communication dans les environments aerien, maritime et terrestre)
caractéristiques de la perception doivent être pris en considération, il faut garder en mémoire qu’un simple stimulus tactile supraliminaire suffit à...with a TSAS system was performed. With an initial investment of capital (R& D funds) of $20M, the 5 year internal rate of return was estimated at 4...device combines off- boresight visual symbology, 3- D audio cueing and a tactile vest. A conceptual drawing is displayed in Figure 1.2. Figure 1.2
STABILIZATION SYSTEM SELECTION. • ". , . „ 7 -^ #*s^ READ INSTRUCTIONS BEFORE COMPLETING FORM 1. RCClPICNfS CATALOG NUMBCN s. rv»c or ntwom...PCRIOD COVERED Final Technical Report, 7 . AUTMORf«; Eugene R. Miller, John J. Slager and William C. Webster •■ »KMrOHMINOOftO. *E»ORT...Destroyer Type Ship at 7 /\\L" 1.2 Figure 20 - Change in Roll Angle as a Function of the Heading Angle for all Sea States; Unstabil’’zed Destroyer Type
PAGE Figure I n-GaAs/n-Ge Profile 10 Fi’,ure 2 AIGaAs/GaAs/Ge Solar Cell - I - V Curve 12 Figure 3(a) AIGaAs/GaAs/Ge Solar Cell - I - V Curve 14 Figure 3...b) Donor Profile for GaAs on Ge 15 Figure 4 AIGaAs/GaAs/Ge Solar Cell - I - V Curve 17 Figure 5 AIGaAs/GaAs/Ge Solar Cell - I - V Curve 18 Figure 6 I-V
purchase of the C-12 in the 1980’s. The C- 12, which is a military version of the Beech Craft ‘ King Air’ was subsequently used by the Marine Corps...MAGTF. The C-12 (Figure 2) is the military version of the Beechcraft King Air. It is often referred to as the ‘workhorse’ of OSA. There are...during major exercises such as Cobra Gold. 39 This would also allow the aircraft to 20 normalize operations in the region, which would better
Dittmer, D. K.; Jhamandas, J. H.; Johnson, E. S.
The commonly used term for solvent abuse, glue sniffing, generally encompasses a variety of substances, including spray paint, thinners, nail varnish remover, gasoline, marking pens, and lighter fluids. Inhaled vapours eventually reach the lipids in the nervous system, where they can be stored for long periods. In three cases of glue-sniffing-related neurotoxicity, the peripheral nervous system was affected in two cases and predominantly the central nervous system in the third. Unfortunately follow up is difficult with this patient population and symptoms are often complicated by alcohol abuse. Images p1966-a Figures 1-2 Figure 3 PMID:8219845
projets devraient aider petit à petit les différentes parties concernées à connaître de mieux en mieux le problème et à planifier les prochaines...3 Figure 2. ISO Risk Principles, Framework, and Process for Managing Risk…………………….12 Figure 3. The ISO 31000 Risk Management Process ...examined only to identify tools or processes that might be of use for BC. There was no intention for a formal examination of the full processes used by
and calf girths, elbow and knee diameters, height and weight. The three somatotype components - endomorphy, mesomorphy and ectomorphy - reflect the...but jusý as musculac (i.e., equivalent fat-free weight and mesomorphy) as SEALs. 12 Figure 1 is a somatochart that displays mean somatotypes for both...Wrestlers -’.z"- -Rowers Referen~ce .. . usIelbolI players . /, .,3 ’ Iiv r lit• ylit Figure 1. Mean somatotypes for SEA’-, BUD/S, various male Olympic sports
24 12. Figure 12: Pulse Height Spectrum for 3He Detector. The energy deposited from an assumed monoenergetic neutron source at energy...source is monoenergetic 0.025 eV neutrons and the mask is 0.08 cm thick. The modulation profile shows that the modulation is very good and close to...best type of neutron source to use for proof-of-concept is one that is monoenergetic . A limitation of the research was that an ideal source could
CRISIS; DEPARTMENT OF DEFENSE SPENDING : HOW TO CONTROL FRAUD, WASTE, AND ABUSE IN THE MILITARY SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS...34~-----:~------------ Date: 2.~ KJ.r~\\ "QI"L 2 Executive Summary Title: Financial Crisis; Department of Defense Spending : How to Control Fraud, Waste... Spending ……………………………….12 Figure 4. Department of Defense Spending FY 2001 - FY 2012……………………….13 LIST OF TABLES Table 1. DoD Base Budget by
Ginley, D.S.; Hietala, V.M.; Martens, J.S.
A transimpedance amplifier for use with high temperature superconducting, other superconducting, and conventional semiconductors allows for appropriate signal amplification and impedance matching to processing electronics. The amplifier incorporates the superconducting flux flow transistor into a differential amplifier configuration which allows for operation over a wide temperature range, and is characterized by high gain, relatively low noise, and response times less than 200 picoseconds over at least a 10-80 K. temperature range. The invention is particularly useful when a signal derived from either far-IR focal plane detectors or from Josephson junctions is to be processed by higher signal/higher impedance electronics, such as conventional semiconductor technology. 12 figures.
This is due to aluminum’s effects on the gills, causing high ventilation rates, low oxygen blood tension, and overall gill damage that include an...there are many similarities between chromium (Cr), essential in glucose metabolism, and aluminum. Urine and plasma samples were taken from diabetic ...53 12. Figure 4-8: TNF-alpha Production….……………………………………………….54 .. 13. Figure 5-1: LD50 Dose Estimates and Low Exposure
An in-vitro dissolution study was conducted on two respirable oxidized depleted uranium samples. The dissolution rates generated from this study were then utilized in the International Commission on Radiological Protection Task Group lung clearance model and a lung clearance model proposed by Cuddihy. Predictions from both models based on the dissolution rates of the amount of oxidized depleted uranium that would be cleared to blood from the pulmonary region following an inhalation exposure were compared. It was found that the predictions made by both models differed considerably. The difference between the predictions was attributed to the differences in the way each model perceives the clearance from the pulmonary region. 33 references, 11 figures, 9 tables.
By using interactive computer graphics (ICG) it is possible to discuss the numerical aspects of some arms race issues with more specificity and in a visual way. The number of variables involved in these issues can be quite large; computers operated in the interactive, graphical mode, can allow exploration of the variables, leading to a greater understanding of the issues. This paper will examine some examples of interactive computer graphics: (1) the relationship between silo hardening and the accuracy, yield, and reliability of ICBMs; (2) target vulnerability (Minuteman, Dense Pack); (3) counterforce vs. countervalue weapons; (4) civil defense; (5) gravitational bias error; (6) MIRV; (7) national vulnerability to a preemptive first strike; (8) radioactive fallout; (9) digital-image processing with charge-coupled devices. 17 references, 11 figures, 1 table.
When Fermilab was designed in the late 1960's and early 1970's, it was anticipated that Neutrino target train servicing could be costly in terms of personnel radiation exposure. This was based in part on the expectation that target intensities of at least 1E13 protons/pulse would be required to produce several neutrino interactions in a large bubble chamber detector. This was indeed later proven to be the case and historically the Neutrino beamline has been targeted with about one half of the protons available from the Main Ring. It was believed that much of the occupational radiation dose from the Neutrino Area could be spared by utilization of a remote manipulator system, which was eventually installed. It is the purpose of this report to examine the use of the Fermilab remote manipulator system and evaluate its cost effectiveness and success as an ALARA (As Low As Reasonably Achievable) tool. 16 references, 11 figures.
A double crystal monochromator is described including two identical, parallel crystals, each of which is cut such that the normal to the diffraction planes of interest makes an angle less than 90 degrees with the surface normal. Diffraction is symmetric, regardless of whether the crystals are symmetrically or asymmetrically cut, enabling operation of the monochromator with a fixed plane of diffraction. As a result of the inclination of the crystal surface, an incident beam has a footprint area which is elongated both vertically and horizontally when compared to that of the conventional monochromator, reducing the heat flux of the incident beam and enabling more efficient surface cooling. Because after inclination of the crystal only a fraction of thermal distortion lies in the diffraction plane, slope errors and the resultant misorientation of the diffracted beam are reduced. 11 figures.
Radmacher, M; Fritz, M; Kacher, C M; Cleveland, J P; Hansma, P K
We have measured force curves as a function of the lateral position on top of human platelets with the atomic force microscope. These force curves show the indentation of the cell as the tip loads the sample. By analyzing these force curves we were able to determine the elastic modulus of the platelet with a lateral resolution of approximately 100 nm. The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm. Images FIGURE 1 FIGURE 7 FIGURE 9 FIGURE 11 FIGURE 12 PMID:8770233
Krol, A.A.; Bell, P.R.F.; Greenfield, P.F.
The mechanisms involved in the leaching of inorganic components from oil shale mined at the Rundle deposit, Queensland, Australia, and retorted by the Lurgi-Ruhrgas process were examined. The phenomena of most significance were found to be solute dissolution, cation exchange, solution speciation and hydrodynamic and unsaturated flow effects. To check on the completeness of this characterization, a model was developed which describes the generation and transport of the major components (Ca, Mg, Na, K, Cl and SO/sub 4/) in the leachate as it infiltrates a column of dry retorted shale. Model predictions compare well with experimental results. It is concluded that the dominant mechanisms which control the rate of leaching have been recognized. 8 references, 11 figures.
Lotka's equations summarizing population dynamics can be approximated by functional models of the survivorship and reproductive curves, incorporating three stages of survival and reproduction, respectively. An abbreviated form uses a single reproductive parameter and two survival values. Survivorship and reproductive curves were fitted to data on northern fur seals (Callorhinus ursinus), domestic and feral sheep, white-tailed deer (Odocoileus virginianus), grizzly bears (Ursus arctos), African buffalo (Syncerus caffer), free-ranging horses, and fin whales (Balaenoptera physalus). Data for 10 species suggest a useful relationship between senescence parameters. A bias due to senescence may lead to serious underestimation of survival rates. Observed annual rates of increase of 18-20% for feral horses, 16% for southern fur seals (Arctocephalus gazella), and 60% for white-tailed deer are compatible with observed population parameters. 43 references, 11 figures, 3 tables.
The objective is to provide technical assistance to METC's effort to develop a leading program in the evaluation of hydrate samples in porous media at reservoir conditions. An existing computer program has been modified to calculate enthalpies of dissociation, equilibrium pressures, and earth temperature-depth profiles for hydrate formation as a function of gas composition. In this report results of the depth-temperature studies are presented. The effect of gas composition, geothermal gradient, permafrost thickness and pressure gradient on the thickness of a hydrate stability zone in permafrost regions is covered. The effect of ocean bottom temperature, gas composition and ocean depth on a hydrate stability zone beneath the ocean is shown. These variables are considered to be among the more important in determining the potential that a particular region has for containing hydrates and they need to be measured in any geological investigation of a region. 24 references, 11 figures, 1 table.
Griffith, R.V.; Huntzinger, C.J.; Thorngate, J.H.
Measurements of neutron spectra produced by the Los Alamos National Laboratory (LANL) Little Boy replica assembly (Comet) were made with a combined multisphere and liquid scintillator system, that has been widely used at the Lawrence Livermore National Laboratory. The combined system was used for measurements at the side (90/sup 0/) and nose (0/sup 0/) of the assembly; additional measurements were made at 45/sup 0/ using only the liquid scintillator. Data were obtained at two meters from the center of the reactive region of the assembly, with good agreement between the multisphere and scintillator results. Comparison with liquid scintillator measurements performed by experimenters from the Canadian Defence Research Establishment, Ottawa (DREO) and calculations from LANL depended on the specific angle, obtaining the best agreement at 90/sup 0/. 32 references, 11 figures, 4 tables.
A planar transparent light conducting means and an improved optically activated electrical switch made using the novel light conducting means are disclosed. The light conducting means further comprise light scattering means on one or more opposite planar surfaces thereof to transmit light from the light conducting means into adjacent media and reflective means on other surfaces of the light conducting means not containing the light scattering means. The optically activated electrical switch comprises at least two stacked photoconductive wafers, each having electrodes formed on both surfaces thereof, and separated by the planar transparent light conducting means. The light scattering means on the light conducting means face surfaces of the wafers not covered by the electrodes to transmit light from the light conducting means into the photoconductive wafers to uniformly illuminate and activate the switch. 11 figures.
Pennock, E.S.; Lillie, R.J.; Zaman, A.S.H.; Yousaf, M.
Approximately 1600 km of seismic reflection profiles from the eastern Salt Range and Potwar Plateau (SR/PP) of Pakistan is integrated with available magnetostratigraphic, surface geologic, and well data to classify structural styles, determine the timing of deformation, and estimate the amount of telescoping of the sedimentary cover. The eastern SR/PP are similar to other fold-and-thrust belts underlain by evaporites in that (1) it is part of a zone of overthrusting that extends considerably farther over the Himalayan foreland than adjacent areas not underlain by evaporites, (2) the overall thrust wedge has a narrow cross-sectional taper, (3) structures verge toward the hinterland as well as toward the foreland, and (4) fold trends are long and continuous, consisting of tight salt-cored anticlines separated by broad synclines. 11 figures, 1 table.
Atac, R.; Fischler, M.S.; Husby, D.E.
A bus switching apparatus and method for multiple processor computer systems comprises a plurality of bus switches interconnected by branch buses. Each processor or other module of the system is connected to a spigot of a bus switch. Each bus switch also serves as part of a backplane of a modular crate hardware package. A processor initiates communication with another processor by identifying that other processor. The bus switch to which the initiating processor is connected identifies and secures, if possible, a path to that other processor, either directly or via one or more other bus switches which operate similarly. If a particular desired path through a given bus switch is not available to be used, an alternate path is considered, identified and secured. 11 figures.
Lasecki, J.V.; Novak, R.F.; McBride, J.R.
A metal to ceramic sealed joint which can withstand wide variations in temperature and maintain a good seal is provided for use in a device adapted to withstand thermal cycling from about 20 to about 1000 degrees C. The sealed joint includes a metal member, a ceramic member having an end portion, and an active metal braze forming a joint to seal the metal member to the ceramic member. The joint is positioned remote from the end portion of the ceramic member to avoid stresses at the ends or edges of the ceramic member. The sealed joint is particularly suited for use to form sealed metal to ceramic joints in a thermoelectric generator such as a sodium heat engine where a solid ceramic electrolyte is joined to metal parts in the system. 11 figures.
Smith, R.D.; Udseth, H.R.
Direct fluid injection mass spectrometry utilizes supercritical fluids for solvation and transfer of materials to a mass spectrometer chemical ionization (CI) source. Available data suggest that any material soluble in a supercritical fluid is transferred efficiently to the ionization region. Mass spectra are presented for mycotoxins of the trichothecene group obtained by use of supercritical carbon dioxide with isobutane as the CI reagent gas. Direct fluid injection MS/MS is also illustrated for major ions in the isobutane chemical ionization of T-2 toxin. The effect of pressure and temperature upon solubility in supercritical fluids is described and illustrated for diacetoxycirpenol. A potential method is also demonstrated for on-line fraction during MS analysis using pressure to control supercritical fluid solubility. Mass spectra are also presented for polar compounds, using supercritical ammonia, and the extension to complex mixtures is described. The fundamental basis and experimental requirements of the direct fluid injection process are discussed. 34 references, 11 figures, 1 table.
Bhattacharyya, D.; Kermode, R.I.; Dickinson, R.L.
The overall objective of this investigation is to provide a critical evaluation of the current information concerning coal-gasification wastewaters and to establish experimentally the extent of separation of phenolics and polynuclear aromatic hydrocarbons (from single and multi-solute synthetic systems) by low-and high-pressure composite membranes. The compounds selected for experimental investigation were: phenol, O-cresol, 2,3-dimethylphenol, catechol, resorcinol, 2-naphthol, naphthalene, and indole. The development of membrane separation processes is gaining considerable importance because of the feasibility of simultaneous removal of organics and inorganic dissolved solids. Cellulose-acetate membranes developed for desalination processes show no rejection of phenolics; however, recently developed thin-film, noncellulosic composite membranes (even at low-pressure operation) may be useful in gasification wastewater reuse schemes. 24 references, 11 figures, 5 tables.
Olson, E S; Smullin, L D
Our studies are concerned with the frequency tuning that is provided by the electrical resonance of tuberous electroreceptors. Frequency selectivity had previously been measured in the electroreceptor's afferent fibers, and resonant conductances in the electroreceptor cell membrane had been implicated in producing the selectivity. With transdermal application of sinusoidal current, we measured the frequency dependence of the impedance of small areas of the electroreceptor/skin structure of the weakly electric fish Sternopygus and Eigenmannia, and used our data to make a quantitative linear model of the structure. The qualitative form of the model was proposed by Bennett (1). The quantitative model allows us to estimate the frequency selectivity of the voltage across the innervated membrane of the electroreceptor cells. The frequency selectivity of electroreceptor cell voltage derived from our data are as sharp as the neural selectivity at frequencies close to the most sensitive frequency. Many of our measurements supported the linear system model. However, spontaneous electroreceptor voltage oscillations were detected in some of our specimens, suggesting that the electroreceptors can operate in a regime of active nonlinearity. A simple explanation for the observed oscillations is that they arise when damping in the electroreceptor cell's resonant membrane is negative for a limited span of membrane voltage surrounding the resting voltage. The response of oscillating units to sinusoidal current was compatible with this explanation. We report experimental observations bearing on the consequences of active nonlinearity for the frequency tuning of a resonant system. Images FIGURE 11 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 11 FIGURE 12 PMID:2765655