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Sample records for 11-year activity cycle

  1. Relationship between the north-south asymmetry of sunspot formation and the amplitude of 11-year solar activity cycles

    NASA Astrophysics Data System (ADS)

    Latyshev, S. V.; Olemskoy, S. V.

    2016-07-01

    A relationship between the north-south asymmetry of sunspot formation and the amplitude of 11-year cycles has been established from the RGO/USAF/NOAA data on sunspots. It is shown that the higher the solar cycle amplitude, the smaller the absolute value of the north-south asymmetry. The revealed pattern has been investigated in a numerical dynamo model with irregular variations of the alpha-effect.

  2. The 11-year cycle in human births

    NASA Astrophysics Data System (ADS)

    Randall, Walter; Moos, Walter S.

    1993-06-01

    The annual numbers of human births were analyzed with regard to an 11-year cycle. The annual values were obtained from seven different regions: Australia, Germany, England and Wales, New Zealand, Japan, Switzerland, and the USA. Fifty-five annual values were obtained from each region for the years 1930 to 1984, comprising approximately five sunspot cycles. For each region the annual values were formed into 5 by 11 matrices; the eleven column means obtained were standardized, and plotted. A periodic regression technique, utilizing the fitting functions of the Fourier series, was used to evaluate the temporal order in the column means. Eleven-year rhythms were found and compared with solar and geophysical variables. Correlations were found with sunspots and solar flares, with terrestrial measures of magnetic disturbances (the magnetic indices derived from the K-index), and with temperature. The correlation of conceptions with the 11-year solar cycle may be a potential guide in the selection of further variables for the control and regulation of the rhythms in human conceptions.

  3. 11 -year planetary index of solar activity

    NASA Astrophysics Data System (ADS)

    Okhlopkov, Victor

    In papers [1,2] introduced me parameter - the average difference between the heliocentric longitudes of planets ( ADL ) , which was used for comparison with solar activity. The best connection of solar activity ( Wolf numbers used ) was obtained for the three planets - Venus, Earth and Jupiter. In [1,2] has been allocated envelope curve of the minimum values ADL which has a main periodicity for 22 years and describes well the alternating series of solar activity , which also has a major periodicity of 22. It was shown that the minimum values of the envelope curve extremes ADL planets Venus, Earth and Jupiter are well matched with the 11- year solar activity cycle In these extremes observed linear configuration of the planets Venus, Earth and Jupiter both in their location on one side of the Sun ( conjunctions ) and at the location on the opposite side of the Sun ( three configurations ) This work is a continuation of the above-mentioned , and here for minimum ADL ( planets are in conjunction ) , as well as on the minimum deviation of the planets from a line drawn through them and Sun at the location of the planets on opposite sides of the Sun , compiled index (denoted for brevity as JEV ) that uniquely describes the 11- year solar cycle A comparison of the index JEV with solar activity during the time interval from 1000 to 2013 conducted. For the period from 1000 to 1699 used the Schove series of solar activity and the number of Wolf (1700 - 2013 ) During the time interval from 1000 to 2013 and the main periodicity of the solar activity and the index ADL is 11.07 years. 1. Okhlopkov V.P. Cycles of Solar Activity and the Configurations of Planets // Moscow University Physics Bulletin, 2012 , Vol. 67 , No. 4 , pp. 377-383 http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.3103/S0027134912040108. 2 Okhlopkov VP, Relationship of Solar Activity Cycles to Planetary Configurations // Bulletin of the Russian Academy of Sciences. Physics, 2013 , Vol. 77 , No. 5

  4. The relationship of air temperature variations over the northern hemisphere during the secular and 11-year solar cycles

    NASA Technical Reports Server (NTRS)

    Ryzhakov, L. Y.; Tomskaya, A. S.

    1978-01-01

    A comparison was made of air temperature anomaly maps for the months of January and July against a background of high and low secular solar activity, with and without regard for the 11 year cycle. By comparing temperature variations during the 11 year and secular cycles, it is found that the 11 year cycle influences thermal conditions more strongly than the secular cycle, and that temperature differences between extreme phases of the solar cycles are greater in January than in July.

  5. Cosmogenic Isotope Variability During the Maunder Minimum: Normal 11-year Cycles Are Expected

    NASA Astrophysics Data System (ADS)

    Poluianov, S. V.; Usoskin, I. G.; Kovaltsov, G. A.

    2014-12-01

    The amplitude of the 11-year cycle measured in the cosmogenic isotope 10Be during the Maunder Minimum is comparable to that during the recent epoch of high solar activity. Because of the virtual absence of the cyclic variability of sunspot activity during the Maunder Minimum this seemingly contradicts an intuitive expectation that lower activity would result in smaller solar-cycle variations in cosmogenic radio-isotope data, or in none, leading to confusing and misleading conclusions. It is shown here that large 11-year solar cycles in cosmogenic data observed during periods of suppressed sunspot activity do not necessarily imply strong heliospheric fields. Normal-amplitude cycles in the cosmogenic radio-isotopes observed during the Maunder Minimum are consistent with theoretical expectations because of the nonlinear relation between solar activity and isotope production. Thus, cosmogenic-isotope data provide a good tool to study solar-cycle variability even during grand minima of solar activity.

  6. Difference between even and odd cycles in the predictability of the amplitude of the around 11-year-period solar activity and prediction of the amplitude of cycle 25

    NASA Astrophysics Data System (ADS)

    Yoshida, A.; Sayre, R. J.

    2012-12-01

    The waxing and waning of the solar activity represented by a period of roughly 11 years is usually quantified by the change in the sunspot number (SSN). It is commonly held that these increases and decreases in the SSN as well as the changes in the general dipole-like magnetic field in the photosphere and corona are produced by a magneto-hydro dynamic process in the sun's underlying convection layer. Assuming this is the case, it follows that SSNs in past cycles should contain a certain kind of information that enables us to estimate the amplitudes of future cycles. We report here a set of new results along this line of research. The chief aim of this paper is to demonstrate a distinct difference in the predictability of solar activity between even and odd cycles. Yoshida and Yamagishi (2010) showed that the SSN at the point three years before a minimum is well correlated with the maximum SSN in the following cycle. Here, we show that the correlation between this locus and the average SSN supplies a higher correlation coefficient. Moreover, we demonstrate that the correlation coefficient for even cycles is far better than that for odd ones (i.e., 0.96 and 0.74, respectively). Though it has been known that the correlation between the SSN at a point three years after a minimum and the maximum SSN is high, we demonstrate here that taking this calculation along with the average SSN (instead of the maximum SSN), the correlation coefficient for even cycles (0.98) reveals itself to be noticeably larger than that for odd cycles (0.93). Furthermore, we have found that the average SSN of even cycles is highly correlated with that of succeeding odd cycles (i.e., the correlation coefficient - minus three outliers - is 0.99). Conversely, no correlation is observed between amplitudes of odd cycles and those of succeeding even cycles. These distinct differences between even-odd pairs and odd-even pairs in their connective features lead us to believe that pairs of even-odd cycles

  7. The stability of decametric type III burst parameters over the 11-year solar activity cycle - The frequency drift rate of radio bursts

    NASA Astrophysics Data System (ADS)

    Abranin, E. P.; Bazelyan, L. L.; Tsybko, Y. G.

    1990-02-01

    Results are presented from measurements of the frequency drift rates for the maximum of the solar type III and IIIb-III bursts in the 25-12.5 MHz range during the period from 1973 to 1984. In the decameter wavelength range, the frequency drift rate is proportional to the value of observational frequency and has a weak dependence on the type of phase within the 11-yr solar cycle. The results are compared with results for the hectometer range, showing that the hectometer type II burst generation process generally occurs at the first harmonic. Data on the frequency dependence of the drift rates at hectometer and decameter wavelengths are consistent with the generation of type II bursts in the streamer at a burst source speed of about 0.3 s.

  8. The 11 years solar cycle as the manifestation of the dark Universe

    DOE PAGES

    Zioutas, K.; Semertzidis, Y.; Tsagri, M.; Papaevangelou, T.; Hoffmann, D. H.H.; Anastassopoulos, V.

    2014-11-26

    Sun’s luminosity in the visible changes at the 10-3 level, following an 11 years period. In X-rays, which should not be there, the amplitude varies even ~105 times stronger, making their mysterious origin since the discovery in 1938 even more puzzling, and inspiring. We suggest that the multifaceted mysterious solar cycle is due to some kind of dark matter streams hitting the Sun. Planetary gravitational lensing enhances (occasionally) slow moving flows of dark constituents towards the Sun, giving rise to the periodic behaviour. Jupiter provides the driving oscillatory force, though its 11.8 years orbital period appears slightly decreased, just asmore » 11 years, if the lensing impact of other planets is included. Then, the 11 years solar clock may help to decipher (overlooked) signatures from the dark sector in laboratory experiments or observations in space.« less

  9. The 11 years solar cycle as the manifestation of the dark Universe

    SciTech Connect

    Zioutas, K.; Semertzidis, Y.; Tsagri, M.; Papaevangelou, T.; Hoffmann, D. H.H.; Anastassopoulos, V.

    2014-11-26

    Sun’s luminosity in the visible changes at the 10-3 level, following an 11 years period. In X-rays, which should not be there, the amplitude varies even ~105 times stronger, making their mysterious origin since the discovery in 1938 even more puzzling, and inspiring. We suggest that the multifaceted mysterious solar cycle is due to some kind of dark matter streams hitting the Sun. Planetary gravitational lensing enhances (occasionally) slow moving flows of dark constituents towards the Sun, giving rise to the periodic behaviour. Jupiter provides the driving oscillatory force, though its 11.8 years orbital period appears slightly decreased, just as 11 years, if the lensing impact of other planets is included. Then, the 11 years solar clock may help to decipher (overlooked) signatures from the dark sector in laboratory experiments or observations in space.

  10. Amplifying the Pacific climate system response to a small 11-year solar cycle forcing.

    PubMed

    Meehl, Gerald A; Arblaster, Julie M; Matthes, Katja; Sassi, Fabrizio; van Loon, Harry

    2009-08-28

    One of the mysteries regarding Earth's climate system response to variations in solar output is how the relatively small fluctuations of the 11-year solar cycle can produce the magnitude of the observed climate signals in the tropical Pacific associated with such solar variability. Two mechanisms, the top-down stratospheric response of ozone to fluctuations of shortwave solar forcing and the bottom-up coupled ocean-atmosphere surface response, are included in versions of three global climate models, with either mechanism acting alone or both acting together. We show that the two mechanisms act together to enhance the climatological off-equatorial tropical precipitation maxima in the Pacific, lower the eastern equatorial Pacific sea surface temperatures during peaks in the 11-year solar cycle, and reduce low-latitude clouds to amplify the solar forcing at the surface.

  11. Amplifying the Pacific climate system response to a small 11-year solar cycle forcing.

    PubMed

    Meehl, Gerald A; Arblaster, Julie M; Matthes, Katja; Sassi, Fabrizio; van Loon, Harry

    2009-08-28

    One of the mysteries regarding Earth's climate system response to variations in solar output is how the relatively small fluctuations of the 11-year solar cycle can produce the magnitude of the observed climate signals in the tropical Pacific associated with such solar variability. Two mechanisms, the top-down stratospheric response of ozone to fluctuations of shortwave solar forcing and the bottom-up coupled ocean-atmosphere surface response, are included in versions of three global climate models, with either mechanism acting alone or both acting together. We show that the two mechanisms act together to enhance the climatological off-equatorial tropical precipitation maxima in the Pacific, lower the eastern equatorial Pacific sea surface temperatures during peaks in the 11-year solar cycle, and reduce low-latitude clouds to amplify the solar forcing at the surface. PMID:19713524

  12. Evidence for climate variations induced by the 11-year solar and cosmic rays cycles

    NASA Astrophysics Data System (ADS)

    Bruckman, William; Ramos, Elio

    2010-02-01

    We analyzed data from PSMSL monthly mean sea level seeking correlations between sea level fluctuations and the solar and cosmic rays 11 year cycle. The data reveals decadal variability that could be causally connected to the solar and cosmic rays cycle, since these periodic changes are correlated. It is also found that the solar (cosmic rays) cycle correlates (anti-correlates) with the mean global surface temperature anomaly. A probable explanation of the above correlations is that the solar intensity and cosmic rays variations induce oscillations in the average temperature and precipitation, with corresponding changes in the continental water and snow accumulation. Thus, for instance, a higher than average snow and water over land, and lower temperatures produce oceans thermal contraction and lower mass, implicating lower mean sea level.

  13. On the ambiguous nature of the 11-year solar cycle signal profile in stratospheric ozone

    NASA Astrophysics Data System (ADS)

    Dhomse, Sandip; Chipperfield, Martyn; Damadeo, Robert; Zawodny, Joe; Ball, William; Feng, Wuhu; Hossaini, Ryan; Mann, Graham; Haigh, Joana

    2016-04-01

    We use three satellite datasets and simulations from a 3-D chemical transport model, forced by three different solar flux datasets, to diagnose the 11-year solar cycle signal (SCS) in stratospheric ozone. Our analysis shows that compared to SAGE II v6.2, a reduced upper stratospheric SCS in SAGE II v7.0 is due to a more realistic ozone-temperature anti-correlation. Overall, all model simulations show a positive SCS in the lower and middle stratosphere and negligible SCS in the upper stratosphere in agreement with SAGE v7.0, HALOE and MLS data. The model simulations show a differently structured SCS over different time periods covered by the satellite datasets, which helps to resolve some observed differences. However, despite the improvements to the SAGE II data, due to remaining biases in current observational and reanalysis datasets, accurate quantification of the influence of solar flux variability on the climate system remains an open scientific question.

  14. The response of chemistry and climate to the 11-year solar cycle in UM-UKCA

    NASA Astrophysics Data System (ADS)

    Bednarz, Ewa; Telford, Paul; Maycock, Amanda; Abraham, Luke; Braesicke, Peter; Pyle, John

    2014-05-01

    It is now generally agreed that the UV variability associated with the 11-year solar cycle leads to changes in ozone and temperature in the upper stratosphere. In addition, a range of observational and modelling studies suggest that such changes are the starting point for a chain of processes (including feedbacks) resulting in circulation changes in many areas of the atmosphere. However, precise details of the interactions between chemistry and meteorology induced by solar variability remain under question. In our study, we use a version of the UM-UKCA chemistry-climate model with consistent spectrally-resolved solar variability. While the solar cycle in heating rates has been applied with the method used in HadGEM2-ES, fine spectrally-resolved solar variability has been uniquely incorporated into the Fast-JX photolysis scheme. We perform two 50-year-long perpetual year solar maximum and solar minimum integrations and complement them with a three member ensemble of a transient 1960-2010 integration in which boundary conditions correspond by and large to the CCMI Ref-C1 scenario. We show how the inferred solar signals vary between the individual experiments. This indicates high natural variability and the resulting contamination of the solar signal with contributions from other processes as well as the existence of possible non-linearities between the solar cycle and other atmospheric forcings. Therefore, we highlight that long data series are needed to ensure correct attribution of the modelled and observed anomalies. In addition, we present results from two perpetual year experiments in which the solar cycle was applied exclusively in either short-wave heating or photolysis. We find large non-linearities in the modelled anomalies as compared to the realistic integration with both modulations included. This highlights the subtle nature of the dynamical response to the solar cycle forcing and indicates the need for interactive chemistry with a detailed photolysis

  15. Using the 11-year Solar Cycle to Predict the Heliosheath Environment at Voyager 1 and 2

    NASA Astrophysics Data System (ADS)

    Michael, A.; Opher, M.; Provornikova, E.; Richardson, J. D.; Toth, G.

    2015-12-01

    As Voyager 2 moves further into the heliosheath, the region of subsonic solar wind plasma in between the termination shock and the heliopause, it has observed an increase of the magnetic field strength to large values, all while maintaining magnetic flux conservation. Dr. Burlaga will present these observations in the 2015 AGU Fall meeting (abstract ID: 59200). The increase in magnetic field strength could be a signature of Voyager 2 approaching the heliopause or, possibly, due to solar cycle effects. In this work we investigate the role the 11-year solar cycle variations as well as magnetic dissipation effects have on the heliosheath environments observed at Voyager 1 and 2 using a global 3D magnetohydrodynamic model of the heliosphere. We use time and latitude-dependent solar wind velocity and density inferred from SOHO/SWAN and IPS data and solar cycle variations of the magnetic field derived from 27-day averages of the field magnitude average of the magnetic field at 1 AU from the OMNI database as presented in Michael et al. (2015). Since the model has already accurately matched the flows and magnetic field strength at Voyager 2 until 93 AU, we extend the boundary conditions to model the heliosheath up until Voyager 2 reaches the heliopause. This work will help clarify if the magnetic field observed at Voyager 2 should increase or decrease due to the solar cycle. We describe the solar magnetic field both as a dipole, with the magnetic and rotational axes aligned, and as a monopole, with magnetic field aligned with the interstellar medium to reduce numerical reconnection within the heliosheath, due to the removal of the heliospheric surrent sheet, and at the solar wind - interstellar medium interface. A comparison of the models allows for a crude estimation of the role that magnetic dissipation plays in the system and whether it allows for a better understanding of the Voyager 2 location in the heliosheath.

  16. Observations and analysis of the Ionospheric Alfven resonance mode structure in a complete 11-year solar cycle

    NASA Astrophysics Data System (ADS)

    Baru, N. A.; Koloskov, A. V.; Yampolsky, Y. M.; Rakhmatulin, R. A.

    2016-03-01

    The long-term data of the ionospheric Alfven resonance (IAR) observations recorded at the Ukrainian Antarctic Station "Akademik Vernadsky" from 2002 to 2013 and at Sayan Solar Observatory (Mondy, Russia) from 2010 to 2013 are analyzed. IAR fine spectral structure is studied and a previously unknown effect of splitting of the several lowest resonance modes is discovered. The diurnal and seasonal dependencies of this effect are investigated as well as the dependences of the probability of IAR and splitting detection on Solar and geomagnetic activities in the 11-year cycle. The morphological features of the splitting frequency behavior are analyzed and three main characteristic periods of the splitting are identified, namely: the development, the stationary period and the disappearing. Possible mechanisms of the splitting effect are suggested.

  17. Cyclicity of Suicides May Be Modulated by Internal or External - 11-Year Cycles: An Example of Suicide Rates in Finland

    NASA Astrophysics Data System (ADS)

    Dimitrov, B. D.; Atanassova, P. A.; Rachkova, M. I.

    2009-12-01

    Multicomponent cyclicity in monthly suicides (periods T = 18, 46 and 198 months) was found and close similarity with heliogeophysical activity (HGA) suggested by Dimitrov in 1999. The current report aimed at scrutinizing the results on suicide annual cyclicity (seasonality) in Slovenia as reported by Oravecz et al in 2007 as well as at analyzing suicide data from Finland in this regard. We postulated that: (i) trans-year (12-24 months) or far-trans-year long-term cycles of suicides might interfere with their seasonality; and (ii) associations to environmental factors with alike cyclicity (e.g. HGA, temperature) could exist. Annual suicide incidence from Oulu, Finland over years 1987-1999 was analyzed. Annual data on solar activity (sunspot index Rz or Wolf number), planetary geomagnetic activity (aa-index) and local daily mean temperatures were used. The exploration of underlying chronomes (time structures) was done by periodogram regression analysis with trigonometric approximation. We analyzed temporal dynamics, revealed cyclicity, decomposed and reconstructed significant cycles and correlated the time series data. Suicide seasonality in Slovenia during the years 1971-2002 (n=384 months, peak May-June) was considered and, although some discrepancies and methodological weaknesses were suspected, we further hypothesized about trans-year and/or longer (far-transyear) cyclic components. Suicide incidence data from Finland indicated that the 12.5-year cyclic component (or trend) was almost parallel (coherent) to the cyclic heliogeophysical parameters and similar to local decreasing temperature dynamics. Also, 8-year and 24.5-year cycles were revealed. A correlation between the 12.5-year suicide cycle and 11-year solar cycle was found (R=0.919, p=0.000009). Above findings on cyclicity and temporal correlations of suicides with cyclic environmental factors, even being still preliminary, might not only allow for further more specific analyses. They might also corroborate

  18. Altitude dependent sensitivity of equatorial atomic oxygen in the MLT region to the quasi-11-year and quasi-27-day solar cycles

    NASA Astrophysics Data System (ADS)

    Lednyts'kyy, Olexandr; Von Savigny, Christian

    2016-07-01

    We retrieved atomic oxygen concentration ([O]) profiles with help of volume emission rate (VER) profiles calculated from the measured by SCIAMACHY (SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY) emissions of green line nightglow in the MLT (Mesosphere/Lower Thermosphere) region. We quantified the sensitivity of equatorial [O] to the 11-year and 27-day solar cycle forcing represented by such proxy indicators of solar activity as MgII index and Lyman-α with help of the wavelet, cross-correlation, superposed epoch, regression and harmonical analysis methods. We applied ordinary least squares bisector fitting on MgII index and F10.7 radio flux, which is measured in solar flux units (sfu), to convert the [O] sensitivity values in sfu and finally in percent changes. The same procedure was performed in the case of Lyman-α. Our results of the sensitivity analysis correspond well to the 11-year solar cycle response of O volume mixing ratios found in simulations performed with the WACCM3 (Whole Atmosphere Community Climate Model, v. 3) and the HAMMONIA (3D Hamburg Model of the Neutral and Ionized Atmosphere) model. We identified an 11-year solar cycle variation, quasi-biennial and annual/semi-annual oscillations as well as signatures of the 27-day cycle of solar activity as presented in the MLT O layer. The most remarkable result is that the found sensitivities agree within their uncertainties and do not depend on averaging method (annual, monthly and daily) of the [O] time series. We report on 11-year and 27-day solar cycle signatures in dependence on altitude intervals used to average the [O] time series.

  19. Relativistic electrons in the outer-zone: An 11 year cycle, their relation to the solar wind

    SciTech Connect

    Belian, R.D.; Cayton, T.E.; Christensen, R.A.; Ingraham, J.C.; Meier, M.M.; Reeves, G.D.; Lazarus, A.J.

    1994-12-31

    We examine Los Alamos energetic electron data from 1979 through the present to show long term trends in the trapped relativistic electron populations at geosynchronous-earth-orbit (GEO). Data is examined from several CPA and SOPA instruments to cover the interval from 1979 through June 1994. It is shown that the higher energy electrons fluxes (E > 300 keV) displayed a cycle of {approx}11 years. In agreement with other investigators, we also show that the relativistic electron cycle is out of phase with the sunspot cycle. We compare the occurrences of relativistic electrons and solar wind high speed streams and determine that on the time scale of 15 years the two do not correlate well. The long-term data set we provide here shows a systematic change of the electron energy spectrum during the course of the solar cycle. This information should be useful to magnetospheric scientists, model designers and space flight planners.

  20. The Antarctic ozone minimum - Relationship to odd nitrogen, odd chlorine, the final warming, and the 11-year solar cycle

    NASA Technical Reports Server (NTRS)

    Callis, L. B.; Natarajan, M.

    1986-01-01

    Photochemical calculations along 'diabatic trajectories' in the meridional phase are used to search for the cause of the dramatic springtime minimum in Antarctic column ozone. The results indicate that the minimum is principally due to catalytic destruction of ozone by high levels of total odd nitrogen. Calculations suggest that these levels of odd nitrogen are transported within the polar vortex and during the polar night from the middle to upper stratosphere and lower mesosphere to the lower stratosphere. The possibility that these levels are related to the 11-year solar cycle and are increased by enhanced formation in the thermosphere and mesosphere during solar maximum conditions is discussed.

  1. New 1982-1990 photometry of Lambda Andromedae and its 11-year cycle

    NASA Technical Reports Server (NTRS)

    Hall, Douglas S.; Henry, Gregory W.; Boehme, Dietmar; Brooks, Peter A.; Chang, Sandy; Dolzan, Ales; Fortier, George L.; Fried, Robert E.; Genet, Russell M.; Grim, Bruce S.

    1991-01-01

    The paper presents photoelectric photometry of Lambda And never before published, obtained between February 1982 and December 1990 at 29 different observatories. Then it is combined with all other photometry available (previously published, contained in the I.A.U. Commission 27 Archives, and obtained with the Vanderbilt 16-inch automatic telescope but not yet published), to yield a 14.8-year data base. Analysis reveals a long-term cycle in mean brightness, with a full range of 0.15 m and a period of 11.4 +/- 0.4 years. Because most of the new photometry was concentrated in the 1983-1984 observing season, this one well-defined light curve is analyzed with a two-spot model. Spot A keeps a 0.04 m amplitude throughout four rotation cycles whereas the amplitude of spot B diminishes from 0.09 m down almost to 0.03 m. The spot rotation periods were 55.9 d +/- 0.6 d and 52.8 d +/- 1.0 d, respectively.

  2. Climate variability related to the 11 year solar cycle as represented in different spectral solar irradiance reconstructions

    NASA Astrophysics Data System (ADS)

    Kruschke, Tim; Kunze, Markus; Misios, Stergios; Matthes, Katja; Langematz, Ulrike; Tourpali, Kleareti

    2016-04-01

    shortwave heating rate differences (additionally collated with line-by-line calculations using libradtran), differences in the photolysis rates, as well as atmospheric circulation features (temperature, zonal wind, geopotential height, etc.). It is shown that atmospheric responses to the different SSI datasets differ significantly from each other. This is a result from direct radiative effects as well as indirect effects induced by ozone feedbacks. Differences originating from using different SSI datasets for the same level of solar activity are in the same order of magnitude as those associated with the 11 year solar cycle within a specific dataset. However, the climate signals related to the solar cycle are quite comparable across datasets.

  3. On dependence of seismic activity on 11 year variations in solar activity and/or cosmic rays

    NASA Astrophysics Data System (ADS)

    Zhantayev, Zhumabek; Khachikyan, Galina; Breusov, Nikolay

    2014-05-01

    It is found in the last decades that seismic activity of the Earth has a tendency to increase with decreasing solar activity (increasing cosmic rays). A good example of this effect may be the growing number of catastrophic earthquakes in the recent rather long solar minimum. Such results support idea on existence a solar-lithosphere relationship which, no doubts, is a part of total pattern of solar-terrestrial relationships. The physical mechanism of solar-terrestrial relationships is not developed yet. It is believed at present that one of the main contenders for such mechanism may be the global electric circuit (GEC) - vertical current loops, piercing and electrodynamically coupling all geospheres. It is also believed, that the upper boundary of the GEC is located at the magnetopause, where magnetic field of the solar wind reconnects with the geomagnetic field, that results in penetrating solar wind energy into the earth's environment. The effectiveness of the GEC operation depends on intensity of cosmic rays (CR), which ionize the air in the middle atmosphere and provide its conductivity. In connection with the foregoing, it can be expected: i) quantitatively, an increasing seismic activity from solar maximum to solar minimum may be in the same range as increasing CR flux; and ii) in those regions of the globe, where the crust is shipped by the magnetic field lines with number L= ~ 2.0, which are populated by anomalous cosmic rays (ACR), the relationship of seismic activity with variations in solar activity will be manifested most clearly, since there is a pronounced dependence of ACR on solar activity variations. Checking an assumption (i) with data of the global seismological catalog of the NEIC, USGS for 1973-2010, it was found that yearly number of earthquake with magnitude M≥4.5 varies into the 11 year solar cycle in a quantitative range of about 7-8% increasing to solar minimum, that qualitatively and quantitatively as well is in agreement with the

  4. The 11-year solar cycle in current reanalyses: a (non)linear attribution study of the middle atmosphere

    NASA Astrophysics Data System (ADS)

    Kuchar, A.; Sacha, P.; Miksovsky, J.; Pisoft, P.

    2015-06-01

    This study focusses on the variability of temperature, ozone and circulation characteristics in the stratosphere and lower mesosphere with regard to the influence of the 11-year solar cycle. It is based on attribution analysis using multiple nonlinear techniques (support vector regression, neural networks) besides the multiple linear regression approach. The analysis was applied to several current reanalysis data sets for the 1979-2013 period, including MERRA, ERA-Interim and JRA-55, with the aim to compare how these types of data resolve especially the double-peaked solar response in temperature and ozone variables and the consequent changes induced by these anomalies. Equatorial temperature signals in the tropical stratosphere were found to be in qualitative agreement with previous attribution studies, although the agreement with observational results was incomplete, especially for JRA-55. The analysis also pointed to the solar signal in the ozone data sets (i.e. MERRA and ERA-Interim) not being consistent with the observed double-peaked ozone anomaly extracted from satellite measurements. The results obtained by linear regression were confirmed by the nonlinear approach through all data sets, suggesting that linear regression is a relevant tool to sufficiently resolve the solar signal in the middle atmosphere. The seasonal evolution of the solar response was also discussed in terms of dynamical causalities in the winter hemispheres. The hypothetical mechanism of a weaker Brewer-Dobson circulation at solar maxima was reviewed together with a discussion of polar vortex behaviour.

  5. Predictors of Meeting Physical Activity and Fruit and Vegetable Recommendations in 9-11-Year-Old Children

    ERIC Educational Resources Information Center

    Beck, Jimikaye; De Witt, Peter; McNally, Janise; Siegfried, Scott; Hill, James O; Stroebele-Benschop, Nanette

    2015-01-01

    Objective: Childhood obesity represents a significant public health problem. This study examined physical activity and nutrition behaviours and attitudes of 9-11-year-olds, and factors influencing these behaviours. Design: Study participants recorded pedometer steps for 7 days and completed physical activity enjoyment, food attitudes and food…

  6. Upper School Maths: Lesson Plans and Activities for Ages 9-11 Years. Series of Caribbean Volunteer Publications, No. 9.

    ERIC Educational Resources Information Center

    Voluntary Services Overseas, Castries (St. Lucia).

    This collection of lesson plans and activities for students aged 9-11 years is based on a science curriculum developed by a group of Caribbean nations. The activities pertain to topics such as place value, prime and composite numbers, the sieve of Eratosthenes, square numbers, factors and multiples, sequences, averages, geometry, symmetry,…

  7. Evaluation of Low-Cost, Objective Instruments for Assessing Physical Activity in 10-11-Year-Old Children

    ERIC Educational Resources Information Center

    Hart, Teresa L.; Brusseau, Timothy; Kulinna, Pamela Hodges; McClain, James J.; Tudor-Locke, Catrine

    2011-01-01

    This study compared step counts detected by four, low-cost, objective, physical-activity-assessment instruments and evaluated their ability to detect moderate-to-vigorous physical activity (MVPA) compared to the ActiGraph accelerometer (AG). Thirty-six 10-11-year-old children wore the NL-1000, Yamax Digiwalker SW 200, Omron HJ-151, and Walk4Life…

  8. Multi-scale harmonic model for solar and climate cyclical variation throughout the Holocene based on Jupiter-Saturn tidal frequencies plus the 11-year solar dynamo cycle

    NASA Astrophysics Data System (ADS)

    Scafetta, Nicola

    2012-05-01

    The Schwabe frequency band of the Zurich sunspot record since 1749 is found to be made of three major cycles with periods of about 9.98, 10.9 and 11.86 years. The side frequencies appear to be closely related to the spring tidal period of Jupiter and Saturn (range between 9.5 and 10.5 years, and median 9.93 years) and to the tidal sidereal period of Jupiter (about 11.86 years). The central cycle may be associated to a quasi-11-year solar dynamo cycle that appears to be approximately synchronized to the average of the two planetary frequencies. A simplified harmonic constituent model based on the above two planetary tidal frequencies and on the exact dates of Jupiter and Saturn planetary tidal phases, plus a theoretically deduced 10.87-year central cycle reveals complex quasi-periodic interference/beat patterns. The major beat periods occur at about 115, 61 and 130 years, plus a quasi-millennial large beat cycle around 983 years. We show that equivalent synchronized cycles are found in cosmogenic records used to reconstruct solar activity and in proxy climate records throughout the Holocene (last 12,000 years) up to now. The quasi-secular beat oscillations hindcast reasonably well the known prolonged periods of low solar activity during the last millennium such as the Oort, Wolf, Spörer, Maunder and Dalton minima, as well as the 17 115-year long oscillations found in a detailed temperature reconstruction of the Northern Hemisphere covering the last 2000 years. The millennial three-frequency beat cycle hindcasts equivalent solar and climate cycles for 12,000 years. Finally, the harmonic model herein proposed reconstructs the prolonged solar minima that occurred during 1900-1920 and 1960-1980 and the secular solar maxima around 1870-1890, 1940-1950 and 1995-2005 and a secular upward trending during the 20th century: this modulated trending agrees well with some solar proxy model, with the ACRIM TSI satellite composite and with the global surface temperature

  9. Harmonic model for solar and climate cyclical variation throughout the Holocene based on Jupiter-Saturn tidal frequencies plus the 11-year solar dynamo cycle

    NASA Astrophysics Data System (ADS)

    Scafetta, N.

    2012-12-01

    We show that the Schwabe frequency band of the Zurich sunspot record since 1749 is made of three major cycles that are closely related to the spring tidal period of Jupiter and Saturn (~9.93 year), to the tidal sidereal period of Jupiter (about 11.86 years) and to a central cycle that may be associated to a quasi-11-year solar dynamo cycle. The central harmonic is approximately synchronized to the average of the two planetary frequencies. A harmonic model based on the above two planetary tidal frequencies and on the exact dates of Jupiter and Saturn planetary tidal phases, plus a theoretically deduced 10.87-year central cycle reveals major beat periods occurring at about 115, 61 and 130 years, plus a quasi-millennial large beat cycle around 983 years. Equivalent synchronized cycles are found in cosmogenic solar proxy records used to reconstruct solar activity and in proxy climate records throughout the Holocene (last 12,000 years) up to now. The quasi-secular beat oscillations hindcast reasonably well the known prolonged periods of low solar activity during the last millennium such as the Oort, Wolf, Sporer, Maunder and Dalton minima, as well as the 17 115-year long oscillations found in a detailed temperature reconstruction of the Northern Hemisphere covering the last 2000 years. The millennial three-frequency beat cycle hindcasts equivalent solar and climate cycles for 12,000 years. Finally, the harmonic model herein proposed reconstructs the prolonged solar minima around 1900-1920 and 1960-1980, the secular solar maxima around 1870-1890, 1940-1950 and 1995-2005, and a secular upward trending during the 20th century. The latter modulated trending agrees well with some solar proxy model, with the ACRIM TSI satellite composite and with the global surface temperature modulation since 1850. The model forecasts a new prolonged solar minimum during 2020-2045, which is produced by the minima of both the 61 and 115-year reconstructed cycles. Finally, the model predicts

  10. Active school transport and weekday physical activity in 9–11-year-old children from 12 countries

    PubMed Central

    Denstel, K D; Broyles, S T; Larouche, R; Sarmiento, O L; Barreira, T V; Chaput, J-P; Church, T S; Fogelholm, M; Hu, G; Kuriyan, R; Kurpad, A; Lambert, E V; Maher, C; Maia, J; Matsudo, V; Olds, T; Onywera, V; Standage, M; Tremblay, M S; Tudor-Locke, C; Zhao, P; Katzmarzyk, P T

    2015-01-01

    OBJECTIVES: Active school transport (AST) may increase the time that children spend in physical activity (PA). This study examined relationships between AST and weekday moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary time (SED) and total activity during naturally organized time periods (daily, before school, during school and after school) in a sample of children from 12 countries. METHODS: The sample included 6224 children aged 9–11 years. PA and sedentary time were objectively measured using Actigraph accelerometers. AST was self-reported by participants. Multilevel generalized linear and logistic regression statistical models were used to determine associations between PA, SED and AST across and within study sites. RESULTS: After adjustment for age, highest parental educational attainment, BMI z-score and accelerometer wear time, children who engaged in AST accumulated significantly more weekday MVPA during all studied time periods and significantly less time in LPA before school compared with children who used motorized transport to school. AST was unrelated to time spent in sedentary behaviors. Across all study sites, AST was associated with 6.0 min (95% confidence interval (CI): 4.7–7.3; P<0.0001) more of weekday MVPA; however, there was some evidence that this differed across study sites (P for interaction=0.06). Significant positive associations were identified within 7 of 12 study sites, with differences ranging from 4.6 min (95% CI: 0.3–8.9; P=0.04, in Canada) to 10.2 min (95% CI: 5.9–14.4; P<0.0001, in Brazil) more of daily MVPA among children who engaged in AST compared with motorized transport. CONCLUSIONS: The present study demonstrated that AST was associated with children spending more time engaged in MVPA throughout the day and less time in LPA before school. AST represents a good behavioral target to increase levels of PA in children. PMID:27152177

  11. The possible mechanism of the "stratospheric bridge" modulation by the Pacific Decadal Oscillation in early winter and the QBO, 11-year solar cycle in late winter

    NASA Astrophysics Data System (ADS)

    Jadin, Evgeny; Wei, Ke; Chen, Wen; Wang, Lin

    Questions of the interannual variations of the extra-tropical stratospheric dynamics, its rela-tionship with the sea surface temperature (SST) anomalies in the North Pacific (Pacific Decadal Oscillation -PDO) in early winter (November-December), Quasi-Biennial Oscillation (QBO) (Holton-Tan relations), a decadal modulation by the 11-year Solar Cycle (SC) (Labitzke, van Loon -LvL correlations) in late winter (January-February) are discussed. In early winter, the interannual changes of the planetary wave activity define partly the variations of the strato-spheric circulation in subsequent January [Zyulyaeva and Jadin, 2009]. The interannual and decadal variations of the stratospheric wave activity appear to be associated with those of the PDO [Jadin et al. 2009]. A decadal period from the mid-1970s to mid-1990s of the violation of the Holton-Tan (HT) relationship corresponds well to that of the positive PDO phase (anoma-lously cold SSTs in the central North Pacific). Using the NCEP and ERA-40 monthly mean reanalysis datasets, the three-dimensional Eliassen-Palm fluxes are calculated. The results of the analysis of relations between the upward/downward propagation of planetary waves in the lower stratosphere ("stratospheric bridge"), their interaction with the zonal wind and the HT and LvL correlations for January-February are presented. In contrast with early winter, the large role in the wave-zonal flow interaction plays the downward propagation of planetary waves from the stratosphere to the troposphere over Canada and North Atlantic ("stratospheric wave hole") responsible for the sink of the eddy energy from the stratosphere. One can suggest that there are two dominant regimes in the stratosphere-troposphere coupling in late winter: 1) the "ventilation regime" with the strong penetration of planetary waves from the troposphere over north Eurasia and their strong downward propagation over Canada and North Atlantic, and 2) the "blocking regime" with the weak those

  12. Claim of solar influence is on thin ice: are 11-year cycle solar minima associated with severe winters in Europe?

    NASA Astrophysics Data System (ADS)

    van Oldenborgh, G. J.; de Laat, A. T. J.; Luterbacher, J.; Ingram, W. J.; Osborn, T. J.

    2013-06-01

    A recent paper in Geophysical Research Letters, ‘Solar influence on winter severity in central Europe’, by Sirocko et al (2012 Geophys. Res. Lett. 39 L16704) claims that ‘weak solar activity is empirically related to extremely cold winter conditions in Europe’ based on analyses of documentary evidence of freezing of the River Rhine in Germany and of the Reanalysis of the Twentieth Century (20C). However, our attempt to reproduce these findings failed. The documentary data appear to be selected subjectively and agree neither with instrumental observations nor with two other reconstructions based on documentary data. None of these datasets show significant connection between solar activity and winter severity in Europe beyond a common trend. The analysis of Sirocko et al of the 20C circulation and temperature is inconsistent with their time series analysis. A physically-motivated consistent methodology again fails to support the reported conclusions. We conclude that multiple lines of evidence contradict the findings of Sirocko et al.

  13. Four minutes of in-class high-intensity interval activity improves selective attention in 9- to 11-year olds.

    PubMed

    Ma, Jasmin K; Le Mare, Lucy; Gurd, Brendon J

    2015-03-01

    The amount of time allocated to physical activity in schools is declining. Time-efficient physical activity solutions that demonstrate their impact on academic achievement-related outcomes are needed to prioritize physical activity within the school curricula. "FUNtervals" are 4-min, high-intensity interval activities that use whole-body actions to complement a storyline. The purpose of this study was to (i) explore whether FUNtervals can improve selective attention, an executive function posited to be essential for learning and academic success; and (ii) examine whether this relationship is predicted by students' classroom off-task behaviour. Seven grade 3-5 classes (n = 88) were exposed to a single-group, repeated cross-over design where each student's selective attention was compared between no-activity and FUNtervals days. In week 1, students were familiarized with the d2 test of attention and FUNterval activities, and baseline off-task behaviour was observed. In both weeks 2 and 3 students completed the d2 test of attention following either a FUNterval break or a no-activity break. The order of these breaks was randomized and counterbalanced between weeks. Neither motor nor passive off-task behaviour predicted changes in selective attention following FUNtervals; however, a weak relationship was observed for verbal off-task behaviour and improvements in d2 test performance. More importantly, students made fewer errors during the d2 test following FUNtervals. In supporting the priority of physical activity inclusion within schools, FUNtervals, a time efficient and easily implemented physical activity break, can improve selective attention in 9- to 11-year olds.

  14. Middle Atmosphere Response to Different Descriptions of the 11-Year Solar Cycle in Spectral Irradiance in a Chemistry-Climate Model

    NASA Technical Reports Server (NTRS)

    Swartz, W. H.; Stolarski, R. S.; Oman, L. D.; Fleming, E. L.; Jackman, C. H.

    2012-01-01

    The 11-year solar cycle in solar spectral irradiance (SSI) inferred from measurements by the SOlar Radiation & Climate Experiment (SORCE) suggests a much larger variation in the ultraviolet than previously accepted. We present middle atmosphere ozone and temperature responses to the solar cycles in SORCE SSI and the ubiquitous Naval Research Laboratory (NRL) SSI reconstruction using the Goddard Earth Observing System chemistry-climate model (GEOS CCM). The results are largely consistent with other recent modeling studies. The modeled ozone response is positive throughout the stratosphere and lower mesosphere using the NRL SSI, while the SORCE SSI produces a response that is larger in the lower stratosphere but out of phase with respect to total solar irradiance above 45 km. The modeled responses in total ozone are similar to those derived from satellite and ground-based measurements, 3-6 Dobson Units per 100 units of 10.7-cm radio flux (F10.7) in the tropics. The peak zonal mean tropical temperature response 50 using the SORCE SSI is nearly 2 K per 100 units 3 times larger than the simulation using the NRL SSI. The GEOS CCM and the Goddard Space Flight Center (GSFC) 2-D coupled model are used to examine how the SSI solar cycle affects the atmosphere through direct solar heating and photolysis processes individually. Middle atmosphere ozone is affected almost entirely through photolysis, whereas the solar cycle in temperature is caused both through direct heating and photolysis feedbacks, processes that are mostly linearly separable. Further, the net ozone response results from the balance of ozone production at wavelengths less than 242 nm and destruction at longer wavelengths, coincidentally corresponding to the wavelength regimes of the SOLar STellar Irradiance Comparison Experiment (SOLSTICE) and Spectral Irradiance Monitor (SIM) on SORCE, respectively. A higher wavelength-resolution analysis of the spectral response could allow for a better prediction of the

  15. Soil carbon and nitrogen cycling and storage throughout the soil profile in a sweetgum plantation after 11 years of CO2-enrichment

    SciTech Connect

    Iversen, Colleen M; Keller, Dr. Jason K.; Garten Jr, Charles T; Norby, Richard J

    2012-01-01

    Increased partitioning of carbon (C) to fine roots under elevated [CO2], especially deep in the soil profile, could alter soil C and nitrogen (N) cycling in forests. After more than 11 years of free-Air CO2 enrichment in a Liquidambar styraciflua L. (sweetgum) plantation in Oak Ridge, TN, USA, greater inputs of fine roots resulted in the incorporation of new C (i.e., C with a depleted 13C) into root-derived particulate organic matter (POM) pools to 90-cm depth. Even though production in the sweetgum stand was limited by soil N availability, soil C and N content increased over time, and were greater throughout the soil profile under elevated [CO2] at the conclusion of the experiment. However, greater C inputs under elevated [CO2] did not result in increased net N immobilization or C mineralization rates in long-term laboratory incubations, and did not appear to prime the decomposition of older SOM. The 13CO2 of the C mineralized from the incubated soil closely tracked the 13C of the labile POM pool in the elevated [CO2] treatment, especially in shallower soil, and did not indicate the decomposition of older (i.e., pre-experiment) SOM. While potential C mineralization rates were positively and linearly related to total soil organic matter (SOM) C content in the top 30 cm of soil, this relationship did not hold in deeper soil. Taken together with an increased mean residence time of C in deeper soil pools, these findings indicate that C inputs from relatively deep roots under elevated [CO2] may have increased potential for long-term storage. Expanded representation of biogeochemical cycling throughout the soil profile may improve model projections of future forest responses to rising atmospheric [CO2].

  16. Hindcast and forecast of grand solar minina and maxima using a three-frequency dynamo model based on Jupiter-Saturn tidal frequencies modulating the 11-year sunspot cycle

    NASA Astrophysics Data System (ADS)

    Scafetta, Nicola

    2016-04-01

    The Schwabe frequency band of the Zurich sunspot record since 1749 is found to be made of three major cycles with periods of about 9.98, 10.9 and 11.86 years. The two side frequencies appear to be closely related to the spring tidal period of Jupiter and Saturn (range between 9.5 and 10.5 years, and median 9.93 years) and to the tidal sidereal period of Jupiter (about 11.86 years). The central cycle can be associated to a quasi-11-year sunspot solar dynamo cycle that appears to be approximately synchronized to the average of the two planetary frequencies. A simplified harmonic constituent model based on the above two planetary tidal frequencies and on the exact dates of Jupiter and Saturn planetary tidal phases, plus a theoretically deduced 10.87-year central cycle reveals complex quasi-periodic interference/beat patterns. The major beat periods occur at about 115, 61 and 130 years, plus a quasi-millennial large beat cycle around 983 years. These frequencies and other oscillations appear once the model is non-linearly processed. We show that equivalent synchronized cycles are found in cosmogenic records used to reconstruct solar activity and in proxy climate records throughout the Holocene (last 12,000 years) up to now. The quasi-secular beat oscillations hindcast reasonably well the known prolonged periods of low solar activity during the last millennium such as the Oort, Wolf, Sporer, Maunder and Dalton minima, as well as the 17 115-year long oscillations found in a detailed temperature reconstruction of the Northern Hemisphere covering the last 2000 years. The millennial cycle hindcasts equivalent solar and climate cycles for 12,000 years. Finally, the harmonic model herein proposed reconstructs the prolonged solar minima that occurred during 1900- 1920 and 1960-1980 and the secular solar maxima around 1870-1890, 1940-1950 and 1995-2005 and a secular upward trending during the 20th century: this modulated trending agrees well with some solar proxy model, with

  17. Cardiorespiratory fitness, activity level, health-related anthropometric variables, sedentary behaviour and socioeconomic status in a sample of Iranian 7-11 year old boys.

    PubMed

    Esmaeilzadeh, S; Kalantari, H; Nakhostin-Roohi, B

    2013-03-01

    The purpose of this study was to evaluate cardiorespiratory fitness (CRF), activity level, some health-related anthropometric variables, sedentary behaviour and socioeconomic status (SES) of 7-11 year old boys in the city of Ardabil, Iran. Of 21 253 school boys aged 7-11 years, 766 participated in this study using the cluster sampling method. Subjects underwent standard anthropometry. One-mile test was used to evaluate [Formula: see text]O2 max. BMI cut-off points were used to identify weight status. Child's TV watching and video playing daily time (TVVPT) was taken for sedentary behaviour evaluation. SES and activity level were measured by standard questionnaires. Of all participants, 8.9% (N=68) of students had CRF lower than normal and 58.6% (N=449) of them had inadequate physical activity. There was a significant adverse relationship between [Formula: see text]O2 max and body mass index (BMI), waist to height ratio (WHtR), waist circumference (WC), and fat mass (FM) (p<0.05). A significant direct association between SES and both FM and TVVPT was observed (p<0.05). Significantly lower physical activity and [Formula: see text]O2 max, and higher TVVPT were observed in the obese boys than their counterparts (p<0.05). The results of this study indicated a significant relationship between CRF and physical activity, and health-related anthropometric variables in a selected sample of 7-11 year boys. Moreover, the obese subjects had not only lower physical activity but also longer sedentary behaviour time than their counterparts.

  18. Habitual Levels of Physical Activity Influence Bone Mass in 11-Year-Old Children From the United Kingdom: Findings From a Large Population-Based Cohort

    PubMed Central

    Tobias, Jon H; Steer, Colin D; Mattocks, Calum G; Riddoch, Chris; Ness, Andy R

    2009-01-01

    We examined the influence of habitual levels of physical activity on bone mass in childhood by studying the relationship between accelerometer recordings and DXA parameters in 4457 11-year-old children. Physical activity was positively related to both BMD and bone size in fully adjusted models. However, further exploration revealed that this effect on bone size was modified by fat mass. Introduction Exercise interventions have been reported to increase bone mass in children, but it is unclear whether levels of habitual physical activity also influence skeletal development. Materials and Methods We used multivariable linear regression to analyze associations between amount of moderate and vigorous physical activity (MVPA), derived from accelerometer recordings for a minimum of 3 days, and parameters obtained from total body DXA scans in 4457 11-year-old boys and girls from the Avon Longitudinal Study of Parents and Children. The influence of different activity intensities was also studied by stratification based on lower and higher accelerometer cut-points for moderate (3600 counts/minute) and vigorous (6200 counts/minute) activity, respectively. Results MVPA was positively associated with lower limb BMD and BMC adjusted for bone area (aBMC; p < 0.001, adjusted for age, sex, socio-economic factors, and height, with or without additional adjustment for lean and fat mass). MVPA was inversely related to lower limb bone area after adjusting for height and lean mass (p = 0.01), whereas a positive association was observed when fat mass was also adjusted for (p < 0.001). Lower limb BMC was positively related to MVPA after adjusting for height and lean and fat mass (p < 0.001), whereas little relationship was observed after adjusting for height and lean mass alone (p = 0.1). On multivariable regression analysis using the fully adjusted model, moderate activity exerted a stronger influence on lower limb BMC compared with light activity (light activity: 2.9 [1.2–4.7, p = 0

  19. Comparison of short-term energy intake and appetite responses to active and seated video gaming, in 8-11-year-old boys.

    PubMed

    Allsop, Susan; Green, Benjamin P; Dodd-Reynolds, Caroline J; Barry, Gillian; Rumbold, Penny L S

    2016-03-28

    The acute effects of active and seated video gaming on energy intake (EI), blood glucose, plasma glucagon-like peptide-1 (GLP-17-36) and subjective appetite (hunger, prospective food consumption and fullness) were examined in 8-11-year-old boys. In a randomised, crossover manner, twenty-two boys completed one 90-min active and one 90-min seated video gaming trial during which food and drinks were provided ad libitum. EI, plasma GLP-17-36, blood glucose and subjective appetite were measured during and following both trials. Time-averaged AUC blood glucose was increased (P=0·037); however, EI was lower during active video gaming (1·63 (sem 0·26) MJ) compared with seated video gaming (2·65 (sem 0·32) MJ) (P=0·000). In a post-gaming test meal 1 h later, there were no significant differences in EI between the active and seated gaming trials. Although estimated energy expenditure was significantly higher during active video gaming, there was still no compensation for the lower EI. At cessation of the trials, relative EI (REI) was significantly lower following active video gaming (2·06 (sem 0·30) MJ) v. seated video gaming (3·34 (sem 0·35) MJ) (P=0·000). No significant differences were detected in time-averaged AUC GLP-17-36 or subjective appetite. At cessation of the active video gaming trial, EI and REI were significantly less than for seated video gaming. In spite of this, the REI established for active video gaming was a considerable amount when considering the total daily estimated average requirement for 8-11-year-old boys in the UK (7·70 MJ). PMID:26817510

  20. Comparison of short-term energy intake and appetite responses to active and seated video gaming, in 8-11-year-old boys.

    PubMed

    Allsop, Susan; Green, Benjamin P; Dodd-Reynolds, Caroline J; Barry, Gillian; Rumbold, Penny L S

    2016-03-28

    The acute effects of active and seated video gaming on energy intake (EI), blood glucose, plasma glucagon-like peptide-1 (GLP-17-36) and subjective appetite (hunger, prospective food consumption and fullness) were examined in 8-11-year-old boys. In a randomised, crossover manner, twenty-two boys completed one 90-min active and one 90-min seated video gaming trial during which food and drinks were provided ad libitum. EI, plasma GLP-17-36, blood glucose and subjective appetite were measured during and following both trials. Time-averaged AUC blood glucose was increased (P=0·037); however, EI was lower during active video gaming (1·63 (sem 0·26) MJ) compared with seated video gaming (2·65 (sem 0·32) MJ) (P=0·000). In a post-gaming test meal 1 h later, there were no significant differences in EI between the active and seated gaming trials. Although estimated energy expenditure was significantly higher during active video gaming, there was still no compensation for the lower EI. At cessation of the trials, relative EI (REI) was significantly lower following active video gaming (2·06 (sem 0·30) MJ) v. seated video gaming (3·34 (sem 0·35) MJ) (P=0·000). No significant differences were detected in time-averaged AUC GLP-17-36 or subjective appetite. At cessation of the active video gaming trial, EI and REI were significantly less than for seated video gaming. In spite of this, the REI established for active video gaming was a considerable amount when considering the total daily estimated average requirement for 8-11-year-old boys in the UK (7·70 MJ).

  1. Physical activity and all-cause mortality among older Brazilian adults: 11-year follow-up of the Bambuí Health and Aging Study

    PubMed Central

    Ramalho, Juciany RO; Mambrini, Juliana VM; César, Cibele C; de Oliveira, César M; Firmo, Josélia OA; Lima-Costa, Maria Fernanda; Peixoto, Sérgio V

    2015-01-01

    Objective To investigate the association between physical activity (eg, energy expenditure) and survival over 11 years of follow-up in a large representative community sample of older Brazilian adults with a low level of education. Furthermore, we assessed sex as a potential effect modifier of this association. Materials and methods A population-based prospective cohort study was conducted on all the ≥60-year-old residents in Bambuí city (Brazil). A total of 1,606 subjects (92.2% of the population) enrolled, and 1,378 (85.8%) were included in this study. Type, frequency, and duration of physical activity were assessed in the baseline survey questionnaire, and the metabolic equivalent task tertiles were estimated. The follow-up time was 11 years (1997–2007), and the end point was mortality. Deaths were reported by next of kin during the annual follow-up interview and ascertained through the Brazilian System of Information on Mortality, Brazilian Ministry of Health. Hazard ratios (95% confidence intervals [CIs]) were estimated by Cox proportional-hazard models, and potential confounders were considered. Results A statistically significant interaction (P<0.03) was found between sex and energy expenditure. Among older men, increases in levels of physical activity were associated with reduced mortality risk. The hazard ratios were 0.59 (95% CI 0.43–0.81) and 0.47 (95% CI 0.34–0.66) for the second and third tertiles, respectively. Among older women, there was no significant association between physical activity and mortality. Conclusion It was possible to observe the effect of physical activity in reducing mortality risk, and there was a significant interaction between sex and energy expenditure, which should be considered in the analysis of this association in different populations. PMID:25931817

  2. Acute effects of active gaming on ad libitum energy intake and appetite sensations of 8-11-year-old boys.

    PubMed

    Allsop, Susan; Dodd-Reynolds, Caroline J; Green, Benjamin P; Debuse, Dorothée; Rumbold, Penny L S

    2015-12-28

    The present study examined the acute effects of active gaming on energy intake (EI) and appetite responses in 8-11-year-old boys in a school-based setting. Using a randomised cross-over design, twenty-one boys completed four individual 90-min gaming bouts, each separated by 1 week. The gaming bouts were (1) seated gaming, no food or drink; (2) active gaming, no food or drink; (3) seated gaming with food and drink offered ad libitum; and (4) active gaming with food and drink offered ad libitum. In the two gaming bouts during which foods and drinks were offered, EI was measured. Appetite sensations - hunger, prospective food consumption and fullness - were recorded using visual analogue scales during all gaming bouts at 30-min intervals and at two 15-min intervals post gaming. In the two bouts with food and drink, no significant differences were found in acute EI (MJ) (P=0·238). Significant differences were detected in appetite sensations for hunger, prospective food consumption and fullness between the four gaming bouts at various time points. The relative EI calculated for the two gaming bouts with food and drink (active gaming 1·42 (sem 0·28) MJ; seated gaming 2·12 (sem 0·25) MJ) was not statistically different. Acute EI in response to active gaming was no different from seated gaming, and appetite sensations were influenced by whether food was made available during the 90-min gaming bouts. PMID:26435259

  3. Acute effects of active gaming on ad libitum energy intake and appetite sensations of 8-11-year-old boys.

    PubMed

    Allsop, Susan; Dodd-Reynolds, Caroline J; Green, Benjamin P; Debuse, Dorothée; Rumbold, Penny L S

    2015-12-28

    The present study examined the acute effects of active gaming on energy intake (EI) and appetite responses in 8-11-year-old boys in a school-based setting. Using a randomised cross-over design, twenty-one boys completed four individual 90-min gaming bouts, each separated by 1 week. The gaming bouts were (1) seated gaming, no food or drink; (2) active gaming, no food or drink; (3) seated gaming with food and drink offered ad libitum; and (4) active gaming with food and drink offered ad libitum. In the two gaming bouts during which foods and drinks were offered, EI was measured. Appetite sensations - hunger, prospective food consumption and fullness - were recorded using visual analogue scales during all gaming bouts at 30-min intervals and at two 15-min intervals post gaming. In the two bouts with food and drink, no significant differences were found in acute EI (MJ) (P=0·238). Significant differences were detected in appetite sensations for hunger, prospective food consumption and fullness between the four gaming bouts at various time points. The relative EI calculated for the two gaming bouts with food and drink (active gaming 1·42 (sem 0·28) MJ; seated gaming 2·12 (sem 0·25) MJ) was not statistically different. Acute EI in response to active gaming was no different from seated gaming, and appetite sensations were influenced by whether food was made available during the 90-min gaming bouts.

  4. A comparison of physical activity and sedentary behaviour in 9–11 year old British Pakistani and White British girls: a mixed methods study

    PubMed Central

    2014-01-01

    Background Previous studies suggest that British children of South Asian origin are less active and more sedentary than White British children. However, little is known about the behaviours underlying low activity levels, nor the familial contexts of active and sedentary behaviours in these groups. Our aim was to test hypotheses about differences between British Pakistani and White British girls using accelerometry and self-reports of key active and sedentary behaviours, and to obtain an understanding of factors affecting these behaviours using parental interviews. Methods Participants were 145 girls (70 White British and 75 British Pakistani) aged 9–11 years and parents of 19 of the girls. Accelerometry data were collected over 4 days and girls provided 24-hour physical activity interviews on 3 of these days. Multilevel linear regression models and generalised linear mixed models tested for ethnic differences in activity, sedentary time, and behaviours. Semi-structured interviews were conducted with parents. Results Compared to White British girls, British Pakistani girls accumulated 102 (95% CI 59, 145) fewer counts per minute and 14 minutes (95% CI 8, 20) less time in moderate to vigorous physical activity per day. British Pakistani girls spent more time (28 minutes per day, 95% CI 14, 42) sedentary. Fewer British Pakistani than White British girls reported participation in organised sports and exercise (OR 0.22 95% CI 0.08, 0.64) or in outdoor play (OR 0.42 95% CI 0.20, 0.91). Fewer British Pakistani girls travelled actively to school (OR 0.26 95% CI 0.10, 0.71). There was no significant difference in reported screen time (OR 0.88 95% CI 0.45, 1.73). Parental interviews suggested that structural constraints (e.g. busy family schedules) and parental concerns about safety were important influences on activity levels. Conclusions British Pakistani girls were less active than White British girls and were less likely to participate in key active behaviours

  5. Relationships between Parental Education and Overweight with Childhood Overweight and Physical Activity in 9–11 Year Old Children: Results from a 12-Country Study

    PubMed Central

    Muthuri, Stella K.; Onywera, Vincent O.; Tremblay, Mark S.; Broyles, Stephanie T.; Chaput, Jean-Philippe; Fogelholm, Mikael; Hu, Gang; Kuriyan, Rebecca; Kurpad, Anura; Lambert, Estelle V.; Maher, Carol; Maia, José; Matsudo, Victor; Olds, Timothy; Sarmiento, Olga L.; Standage, Martyn; Tudor-Locke, Catrine; Zhao, Pei; Church, Timothy S.; Katzmarzyk, Peter T.

    2016-01-01

    Background Globally, the high prevalence of overweight and low levels of physical activity among children has serious implications for morbidity and premature mortality in adulthood. Various parental factors are associated with childhood overweight and physical activity. The objective of this paper was to investigate relationships between parental education or overweight, and (i) child overweight, (ii) child physical activity, and (iii) explore household coexistence of overweight, in a large international sample. Methods Data were collected from 4752 children (9–11 years) as part of the International Study of Childhood Obesity, Lifestyle and the Environment in 12 countries around the world. Physical activity of participating children was assessed by accelerometry, and body weight directly measured. Questionnaires were used to collect parents’ education level, weight, and height. Results Maternal and paternal overweight were positively associated with child overweight. Higher household coexistence of parent-child overweight was observed among overweight children compared to the total sample. There was a positive relationship between maternal education and child overweight in Colombia 1.90 (1.23–2.94) [odds ratio (confidence interval)] and Kenya 4.80 (2.21–10.43), and a negative relationship between paternal education and child overweight in Brazil 0.55 (0.33–0.92) and the USA 0.54 (0.33–0.88). Maternal education was negatively associated with children meeting physical activity guidelines in Colombia 0.53 (0.33–0.85), Kenya 0.35 (0.19–0.63), and Portugal 0.54 (0.31–0.96). Conclusions Results are aligned with previous studies showing positive associations between parental and child overweight in all countries, and positive relationships between parental education and child overweight or negative associations between parental education and child physical activity in lower economic status countries. Relationships between maternal and paternal education

  6. Stellar activity cycles and asteroseismology

    NASA Astrophysics Data System (ADS)

    Salabert, D.

    2011-12-01

    The success of helioseismology is due to its capability to accurately measure the p-mode parameters of the solar eigenmode spectrum, which allow us to infer unique information about the internal structure and dynamics of the Sun from its surface all the way down to the core. It has contributed greatly to a clearer understanding of the Sun and provided insights into the complex solar magnetism, by means for instance of the variability of the characteristics of the p-mode spectrum. Indeed, variations in the mean strength of the solar magnetic field lead to significant shifts in the frequencies of even the lowest-degree p modes with high levels of correlation with solar surface activity proxies. These frequency shifts are explained to arise from structural changes in the outer layers of the Sun during the 11-year activity cycle, which is understood to be driven by a dynamo process. However, clear differences between p-mode frequencies and solar surface activity during the unusually extended minimum of cycle 23 were observed. The origin of the p-mode variability is thus far from being properly understood and a better comprehension of its relationship with solar and stellar activity cycles will help us in our understanding of the dynamo processes. Spectroscopic measurements of Ca H and K emission lines revealed magnetic activity variations in a large sample of solar-type stars with timescales ranging from 2.5 and 25 years. This broad range of cycle periods is thought to reflect differences in the rotational properties and the depths of the surface convection zones with various masses and ages. However, spectroscopic measurements are only good proxies of surface magnetic fields. The recent discovery of variations with magnetic activity in the p-mode oscillation frequencies of the solar-like star HD 49933 observed by CoRoT, with a frequency dependence comparable in shape to the one observed in the Sun, opens a new era in the study of the physical phenomena involved in the

  7. Solar activity secular cycles

    NASA Astrophysics Data System (ADS)

    Kramynin, A. P.; Mordvinov, A. V.

    2013-12-01

    Long-term variations in solar activity secular cycles have been studied using a method for the expansion of reconstructed sunspot number series Sn( t) for 11400 years in terms of natural orthogonal functions. It has been established that three expansion components describe more than 98% of all Sn( t) variations. In this case, the contribution of the first expansion component is about 92%. The averaged form of the 88year secular cycle has been determined based on the form of the first expansion coordinate function. The quasi-periodicities modulating the secular cycle have been revealed based on the time function conjugate to the first function. The quasi-periodicities modulating the secular cycle coincide with those observed in the Sn( t) series spectrum. A change in the secular cycle form and the time variations in this form are described by the second and third expansion components, the contributions of which are about 4 and 2%, respectively. The variations in the steepness of the secular cycle branches are more pronounced in the 200-year cycle, and the secular cycle amplitude varies more evidently in the 2300-year cycle.

  8. Coupling of the Matched Gravity and Electromagnetic Fields of the Sun with Jupiter and its Moons Together in Nearest Portion of Jupiter's Orbit to the Sun as the Main Cause of the Peak of Approximately 11 Yearly Solar Cycles and Hazards from Solar Storms

    NASA Astrophysics Data System (ADS)

    Gholibeigian, Kazem; Gholibeigian, Hassan

    2016-04-01

    strongest variable GEFs in solar system after the Sun. For example, Ganymede is the largest moon of Jupiter and in the Solar System. Completing an orbit in roughly seven days. It means that it generates 52 GEFs oscillations (loading, unloading) per year in solar cycle while it is rotating around the Jupiter. New observations of the planet's extreme ultraviolet emissions show that bright explosions of Jupiter's aurora by the planet-moon interaction, not by solar activity [Tomoki Kimura, JAEA]. Coupling of Jupiter's GEFs and its moons with the Sun generate very strong GEFs and approximately 11 yearly solar cycles. The peaks of each cycle is when the Jupiter passes from the nearest portion of its orbit to the Sun. which some of its peaks generate gigantic solar storms and hazards to the Earth. The Earth passes from between of Sun and Jupiter eleven times in each solar cycle and may be under shooting of storms from the both side specially during 2-3 years in cycle's peak.

  9. Radiocarbon version of 11-year variations in the interplanetary magnetic field since 1250

    NASA Astrophysics Data System (ADS)

    Volobuev, D. M.; Makarenko, N. G.

    2015-12-01

    It is known that the interplanetary magnetic field (IMF), which is controlled by solar activity, modulates the flux of galactic cosmic rays (GCRs). Because GCRs are the only source of the 14C isotope in the atmosphere before the era of atmospheric nuclear tests, the formation rate of this isotope in the atmosphere is one of the few reliable sources of information on solar activity before the initiation of regular telescopic observations. In this study, we solve the inverse problem for the equation of radiocarbon diffusion from the atmosphere into the ocean by calibrating the radiocarbon content in tree rings from 1510 to 1950. We obtain an approximation of 11-year IMF cycles represented by the IDV index from 1872 to 1950. The model extrapolation to the calibration curve for the Korean Peninsula over the time period from 1250 to 1650 makes it possible to calculate the sequence of minima of quasi-11-year cycles since 1250.

  10. Low Physical Activity Level and Short Sleep Duration Are Associated with an Increased Cardio-Metabolic Risk Profile: A Longitudinal Study in 8-11 Year Old Danish Children

    PubMed Central

    Hjorth, Mads F.; Chaput, Jean-Philippe; Damsgaard, Camilla T.; Dalskov, Stine-Mathilde; Andersen, Rikke; Astrup, Arne; Michaelsen, Kim F.; Tetens, Inge; Ritz, Christian; Sjödin, Anders

    2014-01-01

    Background As cardio-metabolic risk tracks from childhood to adulthood, a better understanding of the relationship between movement behaviors (physical activity, sedentary behavior and sleep) and cardio-metabolic risk in childhood may aid in preventing metabolic syndrome (MetS) in adulthood. Objective To examine independent and combined cross-sectional and longitudinal associations between movement behaviors and the MetS score in 8-11 year old Danish children. Design Physical activity, sedentary time and sleep duration (seven days and eight nights) were assessed by accelerometer and fat mass index (fat mass/height2) was assessed using Dual-energy X-ray absorptiometry. The MetS-score was based on z-scores of waist circumference, mean arterial blood pressure, homeostatic model assessment of insulin resistance, triglycerides and high density lipoprotein cholesterol. All measurements were taken at three time points separated by 100 days. Average of the three measurements was used as habitual behavior in the cross-sectional analysis and changes from first to third measurement was used in the longitudinal analysis. Results 723 children were included. In the cross-sectional analysis, physical activity was negatively associated with the MetS-score (P<0.03). In the longitudinal analysis, low physical activity and high sedentary time were associated with an increased MetS-score (all P<0.005); however, after mutual adjustments for movement behaviors, physical activity and sleep duration, but not sedentary time, were associated with the MetS-score (all P<0.03). Further adjusting for fat mass index while removing waist circumference from the MetS-score rendered the associations no longer statistically significant (all P>0.17). Children in the most favorable tertiles of changes in moderate-to-vigorous physical activity, sleep duration and sedentary time during the 200-day follow-up period had an improved MetS-score relative to children in the opposite tertiles (P = 0

  11. Magnetic activity in the young solar analog LQ Hydrae. I. Active longitudes and cycles

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.; Pelt, J.; Tuominen, I.

    2002-11-01

    We present the first evidence that a single active dwarf of solar type can show a long-lived, nonaxisymmetric spot distribution - active longitudes on opposite hemispheres, similar to evolved, rapidly rotating RS CVn-type binary stars. We analyse new as well as published photometric observations of the young active dwarf LQ Hya, spanning almost 20 years. We find that activity of the star has three activity cycles: a 5.2-yr ``flip-flop'' cycle, a 7.7-yr period in the amplitude modulation of the brightness and an approximately 15-yr period in variations of the mean brightness. The two shorter cycles are related to the alternating active longitudes and are similar to cycles observed in RS CVn-type stars. The 15-yr cycle reflects periodic changes of the mean spottedness of the star and resembles the solar 11-year cycle. The spot rotation period (about 1.6 days) changes during the 15-yr cycle, indicating the presence of small differential rotation. The lengths of the three cycles are related as 3:2:1, with the repetition of the spot configuration after 15 years. We discuss the possibility that the observed spot cycles represent two different magnetic dynamo modes operating in LQ Hya: an axisymmetric mode, as in the Sun, and a nonaxisymmetric higher order mode with two cycles in spot patterns. Our results suggest that young stars exhibit their cycles in spot distribution, as seen in LQ Hya. This is in contrast to the conclusion based on the analysis of Ca Ii H&K emission from plages. The results suggest also that the Vaughan-Preston gap represents a transition from a multiple-mode dynamo to a single-mode dynamo. Table 2 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/394/505

  12. Spots, activity cycles, and differential rotation on cool stars

    NASA Astrophysics Data System (ADS)

    Alekseev, I. Yu.

    2005-01-01

    The first results are reported from a search for activity cycles in stars similar to the sun based on modelling their spotting with an algorithm developed at the Crimean Astrophysical Observatory. Of the more than thirty program stars, 10 manifested a cyclical variation in their central latitudes and total starspot area. The observed cycles have durations of 4-15 years, i.e., analogous to the 11 year Schwabe sunspot cycle. Most of the stars have a rough analog of the solar butterfly pattern, with a reduction in the average latitude of the spots as their area increases. A flip-flop effect during the epoch of the maximum average latitude is noted in a number of these objects (e.g., the analog LQ Hya of the young sun or the RS CVn-type variable V711 Tau), as well as a reduction in the photometric rotation period of a star as the spots drift toward the equator, an analog of the differential rotation effect in the sun. Unlike in the sun, the observed spot formation cycles do not correlate uniquely with other indicators of activity— chromospheric emission in the CaII HK lines (Be Cet, EK Dra, Dx Leo), H line emission (LQ Hya, VY Ari, EV Lac), or cyclical flare activity (EV Lac). In V833 Tau, BY Dra, EK Dra, and VY Ari short Schwabe cycles coexist with long cycles that are analogous to the Gleissberg solar cycle, in which the spotted area can approach half the entire area of the star.

  13. CoRoT Reveals a Magnetic Activity Cycle in a Sun-Like Star

    NASA Astrophysics Data System (ADS)

    García, Rafael A.; Mathur, Savita; Salabert, David; Ballot, Jérôme; Régulo, Clara; Metcalfe, Travis S.; Baglin, Annie

    2010-08-01

    The 11-year activity cycle of the Sun is a consequence of a dynamo process occurring beneath its surface. We analyzed photometric data obtained by the CoRoT space mission, showing solarlike oscillations in the star HD49933, for signatures of stellar magnetic activity. Asteroseismic measurements of global changes in the oscillation frequencies and mode amplitudes reveal a modulation of at least 120 days, with the minimum frequency shift corresponding to maximum amplitude as in the Sun. These observations are evidence of a stellar magnetic activity cycle taking place beneath the surface of HD49933 and provide constraints for stellar dynamo models under conditions different from those of the Sun.

  14. A Geomagnetic Precursor Technique for Predicting the Solar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Sobel, E. I.; Rabin, D. M.

    2015-12-01

    The Western hemisphere has been recording sunspot numbers since Galileo discovered sunspots in the early 17th century, and the roughly 11-year solar cycle has been recognized since the 19th century. However, predicting the strength of any particular cycle remains a relatively imprecise task. This project's aim was to update and improve a forecasting technique based on geomagnetic precursors of future solar activity The model is a refinement of R. J. Thompson's 1993 paper that relates the number of geomagnetically disturbed days, as defined by the aa and Ap indices, to the sum of the sunspot number in the current and the previous cycle, Rn + Rn-1.[1] The method exploits the fact that two cycles coexist for some period on the Sun near solar minimum and therefore that the number of sunspots and disturbed days during the declining phase of one cycle gives an indication of the following cycle's strength. We wrote and updated IDL software procedures to define disturbed days with varying threshold values and graphed Rn + Rn-1 against them. The aa threshold was derived from the Ap threshold. After comparing the graphs for Ap values from 20 to 50, an Ap threshold of 30 and the corresponding aa threshold of 44 were chosen as yielding the best correlation. Confidence regions were computed to provide a quantitative uncertainty on future predictions. The 80% confidence region gives a range of ±40 in sunspot number. [1] Thompson, R. J. (1993). A technique for predicting the amplitude of the solar cycle. Solar Physics, 148, 2, 383-388.

  15. USA: 11 years improving energy efficiency

    SciTech Connect

    Not Available

    1982-05-27

    Energy efficiency of the US economy has improved steadily for 11 consecutive years, as shown with data processed by Energy Detente. Between 1970 and 1981, the energy required to produce one constant dollar of goods and services has been reduced by 25.2% and experts expect further reduction in 1982. The same thing is happening in all industrialized countries. If this trend continues and if the world economy recovers in 1983, the developed world will experience times of economic growth without a corresponding increase in energy consumption. If this happens, it would be several years before energy consumption in industrialized countries reaches 1979 levels. However, North America has been doing other things that are promising for OPEC's destiny: Canada's private sector not participating in the Alsands and Cold Lake megaprojects; the political undermining of the Synthetic Fuel Corp. in the US; retreat of Exxon from the Colony (oil shale) project; cancelling or delaying other lesser syncrude projects when oil prices dropped slightly; delay of the Alaskan gas pipeline; and possible extension of time for development of the Orinoco Oil Belt in Venezuela. Brief summaries of energy activities in several Latin American countries and Canada are included. Also, the fuel price/tax series is updated for Western Hemisphere countries.

  16. The Hydrologic Cycle Distributed Active Archive Center

    NASA Technical Reports Server (NTRS)

    Hardin, Danny M.; Goodman, H. Michael

    1995-01-01

    The Marshall Space Flight Center Distributed Active Archive Center in Huntsville, Alabama supports the acquisition, production, archival and dissemination of data relevant to the study of the global hydrologic cycle. This paper describes the Hydrologic Cycle DAAC, surveys its principle data holdings, addresses future growth, and gives information for accessing the data sets.

  17. A possible activity cycle in Proxima Centauri

    NASA Astrophysics Data System (ADS)

    Cincunegui, C.; Díaz, R. F.; Mauas, P. J. D.

    2007-01-01

    Context: Several late-type stars present activity cycles resembling the Solar one. This fact has been observed mostly in stars ranging from F to K, i.e., in stars with a radiative core and an outer convective layer. Aims: This work aims at studying whether an activity cycle can be detected in the dM5.5e star Proxima Centauri, which is supposed to be completely convective. Methods: We present periodical medium-resolution echelle observations covering the complete visual range, which were taken at the CASLEO Argentinean Observatory. These observations are distributed over 7 years. We discarded the spectra that present flare activity, and analyze the remaining activity levels using four different statistical techniques to look for a period of activity. Results: We find strong evidence of a cyclic activity, with a period of ~442 days. We also estimate that the Ca ~II S index varies around 130% due to activity variations outside of flares.

  18. A possible activity cycle in Proxima Centauri

    NASA Astrophysics Data System (ADS)

    Cincunegui, C.; Díaz, R. F.; Mauas, P. J. D.

    Several late-type stars (stars with a radiative core and an outer convective layer) present activity cycles resembling the Solar one. This work aims at studying whether an activity cycle can be detected in the dM5.5e star Proxima Centauri, which is supposed to be completely convective. We present periodical medium-resolution echelle observations covering the complete visual range, which were taken at the CASLEO Argentinean Observatory. These observations are distributed along 7 years. We analize the activity levels to look for a period of activity. We find strong evidence of a cyclic activity, with a period of ˜442 days. We also estimated that the Ca II S index varies around 130% due to activity variations outside of flares.

  19. Forecasting the solar activity cycle: new insights

    NASA Astrophysics Data System (ADS)

    Nandy, Dibyendu; Karak, Bidya Binay

    2013-07-01

    Having advance knowledge of solar activity is important because the Sun's magnetic output governs space weather and impacts technologies reliant on space. However, the irregular nature of the solar cycle makes solar activity predictions a challenging task. This is best achieved through appropriately constrained solar dynamo simulations and as such the first step towards predictions is to understand the underlying physics of the solar dynamo mechanism. In Babcock-Leighton type dynamo models, the poloidal field is generated near the solar surface whereas the toroidal field is generated in the solar interior. Therefore a finite time is necessary for the coupling of the spatially segregated source layers of the dynamo. This time delay introduces a memory in the dynamo mechanism which allows forecasting of future solar activity. Here we discuss how this forecasting ability of the solar cycle is affected by downward turbulent pumping of magnetic flux. With significant turbulent pumping the memory of the dynamo is severely degraded and thus long term prediction of the solar cycle is not possible; only a short term prediction of the next cycle peak may be possible based on observational data assimilation at the previous cycle minimum.

  20. CoRoT reveals a magnetic activity cycle in a Sun-like star.

    PubMed

    García, Rafael A; Mathur, Savita; Salabert, David; Ballot, Jérôme; Régulo, Clara; Metcalfe, Travis S; Baglin, Annie

    2010-08-27

    The 11-year activity cycle of the Sun is a consequence of a dynamo process occurring beneath its surface. We analyzed photometric data obtained by the CoRoT space mission, showing solarlike oscillations in the star HD49933, for signatures of stellar magnetic activity. Asteroseismic measurements of global changes in the oscillation frequencies and mode amplitudes reveal a modulation of at least 120 days, with the minimum frequency shift corresponding to maximum amplitude as in the Sun. These observations are evidence of a stellar magnetic activity cycle taking place beneath the surface of HD49933 and provide constraints for stellar dynamo models under conditions different from those of the Sun. PMID:20798310

  1. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    SciTech Connect

    Buccino, Andrea P.; Petrucci, Romina; Mauas, Pablo J. D.; Jofré, Emiliano

    2014-01-20

    AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R{sub D}{sup ′}), Hα, and Ca II K fluxes at different activity levels of AD Leo, including flares.

  2. The 11-year solar radiation rhythm and the North Atlantic Oscillation during the last two centuries

    NASA Astrophysics Data System (ADS)

    Brunck, Heiko; Sirocko, Frank

    2016-04-01

    The study is based on a historical chronology of freezing events in central Europe during the last 230 years (river Rhine (Sirocko et al. 2012), Baltic Sea (Koslowski and Glaser, 1999) and Lake Constance (Dobras, 1983)). These regions display both significant similarities with extremely cold winters in central Germany for the years 1799, 1830, 1895, 1929, 1940, 1942, 1947, 1956 and 1963, as well as regional differences in timing and severity of cold winters. The statistical analysis of all 92 historical freezing events showed that 80 events occurred during a negative NAOwinter phase. The bootstrap test defined the results as extremely significant. To understand the climatic forcing behind the freezing chronology the NAO data set was smoothed by a three point running mean filter and compared with the 11- year cyclicity of the sunspot numbers. A complete NAO cycle can be observed within each solar cycle back to 1960 and from 1820 to 1900. From 1900 to 1960 the correlation between the Sun and NAO was weak. This on/off mode becomes visible only in the smoothed NAO data, when time intervals longer than "normal" weather observations are analysed. Statistical test for the coherence of the entire 230 years are insignificant. However, the relation is highly significant, if only the intervals from 1960 to 2010 and 1830 to 1900 are analysed. The phase correlation can be explained by temperature variations up to +-2.5°C in time series of stratospheric air temperature at 40 km height, where ozone is formed by ultraviolet solar radiation. Advanced analysis of sea surface temperatures from reanalysis data (ECMWF Data Archiv, 2013) between 30° - 40°N and 65° - 75°N indicate similar temperature variations in phase with the solar activity. Consequently, the 11 year solar periodicity is related to various parts of the Earth/Ocean/Atmosphere system and not only to the stratospheric signal. However, the NAO is the dominating mediator to implement a solar component into the

  3. Stochastic cycle selection in active flow networks.

    PubMed

    Woodhouse, Francis G; Forrow, Aden; Fawcett, Joanna B; Dunkel, Jörn

    2016-07-19

    Active biological flow networks pervade nature and span a wide range of scales, from arterial blood vessels and bronchial mucus transport in humans to bacterial flow through porous media or plasmodial shuttle streaming in slime molds. Despite their ubiquity, little is known about the self-organization principles that govern flow statistics in such nonequilibrium networks. Here we connect concepts from lattice field theory, graph theory, and transition rate theory to understand how topology controls dynamics in a generic model for actively driven flow on a network. Our combined theoretical and numerical analysis identifies symmetry-based rules that make it possible to classify and predict the selection statistics of complex flow cycles from the network topology. The conceptual framework developed here is applicable to a broad class of biological and nonbiological far-from-equilibrium networks, including actively controlled information flows, and establishes a correspondence between active flow networks and generalized ice-type models. PMID:27382186

  4. A Comparison Between Global Proxies of the Sun's Magnetic Activity Cycle: Inferences from Helioseismology

    NASA Astrophysics Data System (ADS)

    Broomhall, A.-M.; Nakariakov, V. M.

    2015-11-01

    The last solar minimum was, by recent standards, unusually deep and long. We are now close to the maximum of the subsequent solar cycle, which is relatively weak. In this article we make comparisons between different global (unresolved) measures of the Sun's magnetic activity to investigate how they are responding to this weak-activity epoch. We focus on helioseismic data, which are sensitive to conditions, including the characteristics of the magnetic field, in the solar interior. Also considered are measures of the magnetic field in the photosphere (sunspot number and sunspot area), the chromosphere and corona (10.7 cm radio flux and 530.3 nm green coronal index), and two measures of the Sun's magnetic activity closer to Earth (the interplanetary magnetic field and the galactic cosmic-ray intensity). Scaled versions of the activity proxies diverge from the helioseismic data around 2000, indicating a change in relationship between the proxies. The degree of divergence varies from proxy to proxy, with sunspot area and 10.7 cm flux showing only small deviations, while sunspot number, coronal index, and the two interplanetary proxies show much larger departures. In Cycle 24 the deviations in the solar proxies and the helioseismic data decrease, raising the possibility that the deviations observed in Cycle 23 are just symptomatic of a 22-year Hale cycle. However, the deviations in the helioseismic data and the interplanetary proxies increase in Cycle 24. Interestingly, the divergence in the solar proxies and the helioseismic data are not reflected in the shorter-term variations (often referred to as quasi-biennial oscillations) observed on top of the dominant 11-year solar cycle. However, despite being highly correlated in Cycle 22, the short-term variations in the interplanetary proxies show very little correlation with the helioseismic data during Cycles 23 and 24.

  5. Geomagnetic activity during 10 - 11 solar cycles that has been observed by old Russian observatories.

    NASA Astrophysics Data System (ADS)

    Seredyn, Tomasz; Wysokinski, Arkadiusz; Kobylinski, Zbigniew; Bialy, Jerzy

    2016-07-01

    A good knowledge of solar-terrestrial relations during past solar activity cycles could give the appropriate tools for a correct space weather forecast. The paper focuses on the analysis of the historical collections of the ground based magnetic observations and their operational indices from the period of two sunspot solar cycles 10 - 11, period 1856 - 1878 (Bartels rotations 324 - 635). We use hourly observations of H and D geomagnetic field components registered at Russian stations: St. Petersburg - Pavlovsk, Barnaul, Ekaterinburg, Nertshinsk, Sitka, and compare them to the data obtained from the Helsinki observatory. We compare directly these records and also calculated from the data of the every above mentioned station IHV indices introduced by Svalgaard (2003), which have been used for further comparisons in epochs of assumed different polarity of the heliospheric magnetic field. We used also local index C9 derived by Zosimovich (1981) from St. Petersburg - Pavlovsk data. Solar activity is represented by sunspot numbers. The correlative and continuous wavelet analyses are applied for estimation of the correctness of records from different magnetic stations. We have specially regard to magnetic storms in the investigated period and the special Carrington event of 1-2 Sep 1859. Generally studied magnetic time series correctly show variability of the geomagnetic activity. Geomagnetic activity presents some delay in relation to solar one as it is seen especially during descending and minimum phase of the even 11-year cycle. This pattern looks similarly in the case of 16 - 17 solar cycles.

  6. [Cerebellar gangliocytoma in an 11-year-old child].

    PubMed

    Joly, Marie; Valmary-Degano, Séverine; Cattin, Françoise; Vasiljevic, Alexandre; Jouvet, Anne; Viennet, Gabriel

    2014-12-01

    Cerebellar gangliocytoma can correspond to Lhermitte-Duclos disease, a benign hamartomatous malformation encountered in young adults. It can also be a part of gangliogliomas/gangliocytomas family, which usually encompasses temporal pediatric neoplasms associated with longstanding seizures. We report a case of a young 11-year-old patient who presented with a gangliocytoma of the cerebellum revealed by neurologic manifestations (headache, dyspraxia, equilibrium and gait disturbances). Diagnosis was made on surgical material. Tumour was characterized by dysplastic mature ganglion cells, perivascular lymphocytic infiltrates and no glial neoplastic component. By immunohistochemistry, ganglion cells expressed neurofilaments, MAP2 protein, synaptophysin, chromogranin A and S100 protein. BRAF V600E mutation was absent. Clinical characteristics, radiology, histopathology of the two main diagnoses are discussed.

  7. First Manic Episode in an 11 Year-old Girl

    PubMed Central

    Tran, Don Quang; Beaudry, Vincent; Lajoie, Yves

    2013-01-01

    Objective: We present the case of an 11 year-old girl admitted to the Centre hospitalier universitaire de Sherbrooke for a first manic episode. Method: Differential diagnoses of adjustment disorder, attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder were considered but eliminated. Results: No organic etiology was detected. Her condition rapidly remitted with aripiprazole 3mg. After her discharge, she suffered a relapse due to instability of her living conditions and was rehospitalized. Conclusion: Mania is a difficult diagnosis in youths due to its nonspecific symptoms, rare prepubertal occurrence, and diagnostic complexity. Despite ongoing research, there is little conclusive information on the impact of psychosocial stressors on the evolution of early-onset bipolar disorder. PMID:24223053

  8. Permanent active longitudes and activity cycles on RS CVn stars

    NASA Astrophysics Data System (ADS)

    Berdyugina, Svetlana V.; Tuominen, Ilkka

    1998-08-01

    A new analysis of the published long-term photometric observations has revealed permanent active-longitude structures in four RS CVn stars: EI Eri, II Peg, sigma Gem, and HR 7275. Two active longitudes separated by half of the period are found to dominate on the surface during all available seasons. The positions of the longitudes on three stars (EI Eri, II Peg, HR 7275) are migrating in the orbital reference frame, and there is no preferred orientation with respect to the line of centres in the binaries. The rate of migration is approximately constant. In case of sigma Gem the active longitude migration is synchronized with the orbital motion in the direction of the line of centres in the binary. The active region lifetimes can be longer than the time span of the observations (>=15 yr). The periods of the active longitude rotation are determined: for EI Eri 1fd 9510, for II Peg 6fd 7066, for sigma Gem 19fd 604, for HR 7275 28fd 263. Long-term activity cycles of the stars are discovered from the analysis of the relative contribution of the two longitudes to the photometric variability. One longitude is found to be usually more active than the other at a given moment, and the change of the activity level between the longitudes is cyclic with periods of years. The switch of the activity takes a much shorter time, about a few months, similar to the ``flip-flop'' phenomenon found for FK Com stars. Moments of switching are regarded as new tracers of the activity, and total cycles, which return activity to the same longitude, are found to be for EI Eri 9.0 yr, for II Peg 9.3 yr, for sigma Gem 14.9 yr, for HR 7275 17.5 yr.

  9. Farming tractor fatalities in Virginia: an 11-year retrospective review.

    PubMed

    Fulcher, James; Noller, Anna; Kay, Deborah

    2012-12-01

    This retrospective case review examines farm tractor-related deaths in the Commonwealth of Virginia for an 11-year period, from 1997 to 2007. This study compares decedent's demographic information, toxicology results, and medical histories.A vast majority of farm tractor-related deaths were male (98%) and white (91%). The average age was 60 years with most deaths occurring between the ages of 40 and 80 years. Ethanol use was observed in 9% of all cases with 7% of cases being more than 0.08% wt/vol ethanol, which is the legal limit in Virginia to operate a motor vehicle.The more mountainous, Western District Office of the Chief Medical Examiner composed 60% of total cases with 43% of these western cases related to tractor use on a natural slope or incline. The deaths in other districts were all less than 13% natural slope or incline related, reflecting the topography of these areas.These findings confirm much of what observation would suggest; accidents with farming tractors typically involve older white men. Operating a tractor on steep inclines is dangerous as many tractors do not have adequate rollover protection. The use of ethanol is dangerous when using any heavy equipment.This study provides an initial look at tractor-related deaths in Virginia, and more research is needed in this area to improve safety mechanisms on this machinery.

  10. Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia.

    PubMed

    Östlund, Eva; Al-Nashi, Maha; Hamad, Rangeen Rafik; Larsson, Anders; Eriksson, Maria; Bremme, Katarina; Kahan, Thomas

    2013-12-01

    Women with a history of preeclampsia are at increased risk of future cardiovascular disease. Preeclampsia is associated with elevated blood pressure, inflammation and endothelial dysfunction, and these findings remain 1 year after delivery. Whether these abnormalities persist long after delivery, and whether they may contribute to future cardiovascular disease, is not well studied. We studied 15 women with a history of preeclampsia and 16 matched controls with an uncomplicated pregnancy 11 years following the index pregnancy; all had also been previously examined at 1 year. We assessed arterial stiffness (pulse wave analysis), 24 h ambulatory blood pressure and endothelial function (forearm flow-mediated dilatation and pulse wave analysis following β receptor agonist provocation), and determined markers of glucose and lipid metabolism, inflammation and vascular function. The preeclampsia group had higher blood pressures and reduced night/day blood pressure ratios, increased body mass index and reduced glucose tolerance, and increased levels of tissue necrosis factor receptor 1 and intracellular adhesion molecule-1, suggesting inflammatory and vascular activation. However, the endothelial impairment observed in the preeclampsia group at 1 year was normalized at 11 years, whereas the control group remained unchanged during follow-up. Our findings of higher blood pressures, impaired glucose tolerance and normalization of endothelial function 11 years after preeclampsia suggest cardiovascular risk factors present already before pregnancy to be more important than permanent endothelial damage for the increased risk of future cardiovascular complications in women with a history of preeclampsia.

  11. Coronal activity cycles in solar analog stars

    NASA Astrophysics Data System (ADS)

    Favata, Fabio

    2013-10-01

    We propose continuation into AO13 of the ongoing long-term program for the monitoring of coronal cycles in a sample of five solar-type stars in three stellar systems. The targets have been monitored continuously since AO1, yielding the first unambiguous evidence of cyclic behavior in the X-ray emission from the coronae of cool stars. Thanks to the long-term monitoring our program is starting to show evidence of the complex behavior of stellar cycles, with significant cycle-to-cycle variability becoming apparent. The observations requested in AO-13 will allow us to capitalize on our long-term investment of XMM-Newton observing time and to continue assembling a unique long-term data set that is likely to remain unmatched for a long time.

  12. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.; Upton, Lisa

    2013-01-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow can modulate the amplitude of the following sunspot cycle through its influence on the Sun's polar fields.

  13. Carotid Artery Stenting: Single-Center Experience Over 11 Years

    SciTech Connect

    Nolz, Richard Schernthaner, Ruediger Egbert; Cejna, Manfred; Schernthaner, Melanie Lammer, Johannes Schoder, Maria

    2010-04-15

    This article reports the results of carotid artery stenting during an 11-year period. Data from 168 carotid artery stenting procedures (symptomatic, n = 55; asymptomatic, n = 101; symptoms not accessible, n = 12) were retrospectively collected. Primary technical success rate, neurological events in-hospital, access-site complications, and contrast-induced nephropathy (n = 118) were evaluated. To evaluate the influence of experience in carotid artery stenting on intraprocedural neurologic complications, patients were divided into two groups. Group 1 included the first 80 treated patients, and group 2 the remainder of the patients (n = 88). In-stent restenoses at last-follow-up examinations (n = 89) were assessed. The overall primary technical success rate was 95.8%. The in-hospital stroke-death rate was 3.0% (n = 5; symptomatic, 5.4%; asymptomatic, 2.0%; p = 0.346). Neurologic complications were markedly higher in group 1 (4.2%; three major strokes; symptomatic, 2.8%, asymptomatic, 1.4%) compared to group 2 (2.4%; one major and one minor stroke-symptomatic, 1.2%, asymptomatic 1.2%), but this was not statistically significant. Further complications were access-site complications in 12 (7.1%), with surgical revision required in 1 (0.6%) and mild contrast-induced nephropathy in 1 (0.85%). Twenty-one (23.6%) patients had >50% in-stent restenosis during a mean follow-up of 28.2 months. In conclusion, advanced experience in carotid artery stenting leads to an acceptable periprocedural stroke-death rate. In-stent restenosis could be a critical factor during the follow-up course.

  14. Rest-Activity Cycles in Childhood and Adolescent Depression.

    ERIC Educational Resources Information Center

    Armitage, Roseanne; Hoffmann, Robert; Emslie, Graham; Rintelman, Jeanne; Moore, Jarrette; Lewis, Kelly

    2004-01-01

    Objective: To quantify circadian rhythms in rest-activity cycles in depressed children and adolescents. Method: Restactivity cycles were evaluated by actigraphy over five consecutive 24-hour periods in 100 children and adolescents, including 59 outpatients with major depressive disorder (MDD) and 41 healthy normal controls. Total activity, total…

  15. A 12-year Activity Cycle for the Nearby Planet Host Star HD 219134

    NASA Astrophysics Data System (ADS)

    Johnson, Marshall C.; Endl, Michael; Cochran, William D.; Meschiari, Stefano; Robertson, Paul; MacQueen, Phillip J.; Brugamyer, Erik J.; Caldwell, Caroline; Hatzes, Artie P.; Ramírez, Ivan; Wittenmyer, Robert A.

    2016-04-01

    The nearby (6.5 pc) star HD 219134 was recently shown by Motalebi et al. and Vogt et al. to host several planets, the innermost of which is transiting. We present 27 years of radial velocity (RV) observations of this star from the McDonald Observatory Planet Search program, and 19 years of stellar activity data. We detect a long-period activity cycle measured in the Ca ii SHK index, with a period of 4230 ± 100 days (11.7 years), very similar to the 11 year solar activity cycle. Although the period of the Saturn-mass planet HD 219134 h is close to half that of the activity cycle, we argue that it is not an artifact due to stellar activity. We also find a significant periodicity in the SHK data due to stellar rotation with a period of 22.8 days. This is identical to the period of planet f identified by Vogt et al., suggesting that this RV signal might be caused by rotational modulation of stellar activity rather than a planet. Analysis of our RVs allows us to detect the long-period planet HD 219134 h and the transiting super-Earth HD 219134 b. Finally, we use our long time baseline to constrain the presence of longer period planets in the system, excluding to 1σ objects with M{sin}i\\gt 0.36{M}J at 12 years (corresponding to the orbital period of Jupiter) and M{sin}i\\gt 0.72{M}J at a period of 16.4 years (assuming a circular orbit for an outer companion).

  16. Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up.

    PubMed

    Shaked, Y; Blau, A; Shpilberg, O; Samra, Y

    1993-08-01

    Hyporeninemic hypoaldosteronism is an important underlying condition, causing hyperkalemia with hyperchloremic metabolic acidosis, disproportionate to the degree of renal insufficiency present. The principal defect in this syndrome is a reduced level of plasma renin activity, which results in secondary hypoaldosteronism. Diabetes mellitus is usually the primary underlying renal disease, though other causes of renal diseases associated with this syndrome have been described. This case report describes for the first time an elderly patient with multiple myeloma, in remission for more than 11 years, associated with the syndrome of hyporeninemic hypoaldosteronism at the time of diagnosis. The complete resolution of the syndrome after vigorous chemotherapy is an intriguing possibility.

  17. Inferences on Stellar Activity and Stellar Cycles from Asteroseismology

    NASA Astrophysics Data System (ADS)

    Chaplin, William J.; Basu, Sarbani

    2014-12-01

    The solar activity cycle can be studied using many different types of observations, such as counting sunspots, measuring emission in the Ca II H&K lines, magnetograms, radio emissions, etc. One of the more recent ways of studying solar activity is to use the changing properties of solar oscillations. Stellar activity cycles are generally studied using the Ca II lines, or sometimes using photometry. Asteroseismology is potentially an exciting means of studying these cycles. In this article we examine whether or not asteroseismic data can be used for this purpose, and what the asteroseismic signatures of stellar activity are. We also examine how asteroseismology may help in more indirect ways.

  18. COUPLING THE SOLAR DYNAMO AND THE CORONA: WIND PROPERTIES, MASS, AND MOMENTUM LOSSES DURING AN ACTIVITY CYCLE

    SciTech Connect

    Pinto, Rui F.; Brun, Allan Sacha; Grappin, Roland

    2011-08-20

    We study the connections between the Sun's convection zone and the evolution of the solar wind and corona. We let the magnetic fields generated by a 2.5-dimensional (2.5D) axisymmetric kinematic dynamo code (STELEM) evolve in a 2.5D axisymmetric coronal isothermal magnetohydrodynamic code (DIP). The computations cover an 11 year activity cycle. The solar wind's asymptotic velocity varies in latitude and in time in good agreement with the available observations. The magnetic polarity reversal happens at different paces at different coronal heights. Overall the Sun's mass-loss rate, momentum flux, and magnetic braking torque vary considerably throughout the cycle. This cyclic modulation is determined by the latitudinal distribution of the sources of open flux and solar wind and the geometry of the Alfven surface. Wind sources and braking torque application zones also vary accordingly.

  19. Forecasting the Peak of the Present Solar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Hamid, Rabab; Marzouk, Beshir

    2016-07-01

    Solar forecasting of the level of sun Activity is very important subject for all space programs. Most predictions are based on the physical conditions prevailing at or before the solar cycle minimum preceding the maximum in question. Our aim is to predict the maximum peak of cycle 24 using precursor techniques in particular those using spotless event, geomagnetic aa min. index and solar flux F10.7. Also prediction of exact date of the maximum (Tr) is taken in consideration. A study of variation over previous spotless event for cycles 7-23 and that for even cycles (8-22) are carried out for the prediction. Linear correlation between RM and spotless event around the preceding minimum gives RM24t = 101.9with rise time Tr = 4.5 Y. For the even cycles RM24e = 108.3 with rise time Tr = 3.9 Y. Based on the average aa min. index for the year of sunspot minimum cycles (13 - 23), we estimate the expected amplitude for cycle 24 to be RMaa = 116.5 for both the total and even cycles. Application of the data of solar flux F10.7 which cover only cycles (19-23) was taken in consideration and gives predicted maximum amplitude R24 10.7 = 146, which are over estimation. Our result indicating a somewhat weaker cycle 24 as compared to cycles 21-23.

  20. Response of Solar Oscillations to Magnetic Activity in Cycle 24

    NASA Astrophysics Data System (ADS)

    Jain, K.; Tripathy, S. C.; Hill, F.

    2015-12-01

    Acoustic mode parameters are generally used to study the variability of the solar interior in response to changing magnetic activity. While oscillation frequencies do vary in phase with the solar activity, the mode amplitudes are anti-correlated. Now, continuous measurements from ground and space allow us study the origin of such variability in detail. Here we use intermediate-dgree mode frequencies computed from a ground-based 6-site network ( GONG), covering almost two solar cycles from the minimum of cycle 23 to the declining phase of cycle 24, to investigate the effect of remarkably low solar activity on the solar oscillations in current cycle and the preceding minimum; is the response of acoustic oscillations to magnetic activity in cycle 24 similar to cycle 23 or there are differences between cycles 23 and 24? In this paper, we analyze results for both solar cycles, and try to understand the origin of similarities/differences between them. We will also compare our findings with the contemporaneous observations from space (SOHO/MDI and SDO/HMI).

  1. The connection between stellar activity cycles and magnetic field topology

    NASA Astrophysics Data System (ADS)

    See, V.; Jardine, M.; Vidotto, A. A.; Donati, J.-F.; Boro Saikia, S.; Bouvier, J.; Fares, R.; Folsom, C. P.; Gregory, S. G.; Hussain, G.; Jeffers, S. V.; Marsden, S. C.; Morin, J.; Moutou, C.; do Nascimento, J. D.; Petit, P.; Waite, I. A.

    2016-08-01

    Zeeman Doppler imaging has successfully mapped the large-scale magnetic fields of stars over a large range of spectral types, rotation periods and ages. When observed over multiple epochs, some stars show polarity reversals in their global magnetic fields. On the Sun, polarity reversals are a feature of its activity cycle. In this paper, we examine the magnetic properties of stars with existing chromospherically determined cycle periods. Previous authors have suggested that cycle periods lie on multiple branches, either in the cycle period-Rossby number plane or the cycle period-rotation period plane. We find some evidence that stars along the active branch show significant average toroidal fields that exhibit large temporal variations while stars exclusively on the inactive branch remain dominantly poloidal throughout their entire cycle. This lends credence to the idea that different shear layers are in operation along each branch. There is also evidence that the short magnetic polarity switches observed on some stars are characteristic of the inactive branch while the longer chromospherically determined periods are characteristic of the active branch. This may explain the discrepancy between the magnetic and chromospheric cycle periods found on some stars. These results represent a first attempt at linking global magnetic field properties obtained form ZDI and activity cycles.

  2. A solar cycle timing predictor - The latitude of active regions

    NASA Technical Reports Server (NTRS)

    Schatten, Kenneth H.

    1990-01-01

    A 'Spoerer butterfly' method is used to examine solar cycle 22. It is shown from the latitude of active regions that the cycle can now be expected to peak near November 1989 + or - 8 months, basically near the latter half of 1989.

  3. The connection between stellar activity cycles and magnetic field topology

    NASA Astrophysics Data System (ADS)

    See, V.; Jardine, M.; Vidotto, A. A.; Donati, J.-F.; Boro Saikia, S.; Bouvier, J.; Fares, R.; Folsom, C. P.; Gregory, S. G.; Hussain, G.; Jeffers, S. V.; Marsden, S. C.; Morin, J.; Moutou, C.; do Nascimento, J. D.; Petit, P.; Waite, I. A.

    2016-11-01

    Zeeman-Doppler imaging (ZDI) has successfully mapped the large-scale magnetic fields of stars over a large range of spectral types, rotation periods and ages. When observed over multiple epochs, some stars show polarity reversals in their global magnetic fields. On the Sun, polarity reversals are a feature of its activity cycle. In this paper, we examine the magnetic properties of stars with existing chromospherically determined cycle periods. Previous authors have suggested that cycle periods lie on multiple branches, either in the cycle period-Rossby number plane or the cycle period-rotation period plane. We find some evidence that stars along the active branch show significant average toroidal fields that exhibit large temporal variations while stars exclusively on the inactive branch remain dominantly poloidal throughout their entire cycle. This lends credence to the idea that different shear layers are in operation along each branch. There is also evidence that the short magnetic polarity switches observed on some stars are characteristic of the inactive branch while the longer chromospherically determined periods are characteristic of the active branch. This may explain the discrepancy between the magnetic and chromospheric cycle periods found on some stars. These results represent a first attempt at linking global magnetic field properties obtained from ZDI and activity cycles.

  4. Butterfly Diagram and Activity Cycles in HR 1099

    NASA Astrophysics Data System (ADS)

    Berdyugina, Svetlana V.; Henry, Gregory W.

    2007-04-01

    We analyze photometric data of the active RS CVn-type star HR 1099 for the years 1975-2006 with an inversion technique and reveal the nature of two activity cycles of 15-16 yr and 5.3+/-0.1 yr duration. The 16 yr cycle is related to variations of the total spot area and is coupled with the differential rotation, while the 5.3 yr cycle is caused by the symmetric redistribution of the spotted area between the opposite stellar hemispheres (flip-flop cycle). We recover long-lived active regions comprising two active longitudes that migrate in the orbital reference frame with a variable rate because of the differential rotation along with changes in the mean spot latitudes. The migration pattern is periodic with the 16 yr cycle. Combining the longitudinal migration of the active regions with a previously measured differential rotation law, we recover the first stellar butterfly diagram without an assumption about spot shapes. We find that mean latitudes of active regions at opposite longitudes change antisymmetrically in the course of the 16 yr cycle: while one active region migrates to the pole, the other approaches the equator. This suggests a precession of the global magnetic field with respect to the stellar rotational axis.

  5. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.; Upton, Lisa

    2013-01-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow should also modulate the amplitude of the following sunspot cycle through its influence on the Sun's polar fields. The observational evidence and the theoretical consequences (similar to those of Cameron and Schussler (2012)) will be described.

  6. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Astrophysics Data System (ADS)

    Hathaway, David H.; Upton, L.

    2013-07-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow should also modulate the amplitude of the following sunspot cycle through its influence on the Sun’s polar fields. The observational evidence and the theoretical consequences (similar to those of Cameron and Schussler (2012)) will be described. Komm, Howard, and Harvey (1993) Solar Phys. 147, 207. Cameron and Schussler (2012) Astron. Astrophys. 548, A57.

  7. Communicating the science of the 11-year sunspot cycle to the general public

    NASA Astrophysics Data System (ADS)

    Choudhuri, A. R.

    2015-03-01

    Astrophysics is one branch of science which excites the imagination of the general public. Pioneer science popularizers like George Gamow and Fred Hoyle wrote on different aspects of astrophysics. However, of late, we see a trend which I find disturbing. While it has become extremely fashionable to write popular science books on cosmology, other areas of astrophysics are grossly neglected.

  8. Geothermal activity helps life survive glacial cycles.

    PubMed

    Fraser, Ceridwen I; Terauds, Aleks; Smellie, John; Convey, Peter; Chown, Steven L

    2014-04-15

    Climate change has played a critical role in the evolution and structure of Earth's biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this "geothermal glacial refugia" hypothesis has yet been undertaken, but Antarctica provides a unique setting for doing so. The continent has experienced repeated glaciations that most models indicate blanketed the continent in ice, yet many Antarctic species appear to have evolved in almost total isolation for millions of years, and hence must have persisted in situ throughout. How could terrestrial species have survived extreme glaciation events on the continent? Under a hypothesis of geothermal glacial refugia and subsequent recolonization of nongeothermal regions, we would expect to find greater contemporary diversity close to geothermal sites than in nongeothermal regions, and significant nestedness by distance of this diversity. We used spatial modeling approaches and the most comprehensive, validated terrestrial biodiversity dataset yet created for Antarctica to assess spatial patterns of diversity on the continent. Models clearly support our hypothesis, indicating that geothermally active regions have played a key role in structuring biodiversity patterns in Antarctica. These results provide critical insights into the evolutionary importance of geothermal refugia and the history of Antarctic species.

  9. Geothermal activity helps life survive glacial cycles

    PubMed Central

    Fraser, Ceridwen I.; Terauds, Aleks; Smellie, John; Convey, Peter; Chown, Steven L.

    2014-01-01

    Climate change has played a critical role in the evolution and structure of Earth’s biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this “geothermal glacial refugia” hypothesis has yet been undertaken, but Antarctica provides a unique setting for doing so. The continent has experienced repeated glaciations that most models indicate blanketed the continent in ice, yet many Antarctic species appear to have evolved in almost total isolation for millions of years, and hence must have persisted in situ throughout. How could terrestrial species have survived extreme glaciation events on the continent? Under a hypothesis of geothermal glacial refugia and subsequent recolonization of nongeothermal regions, we would expect to find greater contemporary diversity close to geothermal sites than in nongeothermal regions, and significant nestedness by distance of this diversity. We used spatial modeling approaches and the most comprehensive, validated terrestrial biodiversity dataset yet created for Antarctica to assess spatial patterns of diversity on the continent. Models clearly support our hypothesis, indicating that geothermally active regions have played a key role in structuring biodiversity patterns in Antarctica. These results provide critical insights into the evolutionary importance of geothermal refugia and the history of Antarctic species. PMID:24616489

  10. Geothermal activity helps life survive glacial cycles.

    PubMed

    Fraser, Ceridwen I; Terauds, Aleks; Smellie, John; Convey, Peter; Chown, Steven L

    2014-04-15

    Climate change has played a critical role in the evolution and structure of Earth's biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this "geothermal glacial refugia" hypothesis has yet been undertaken, but Antarctica provides a unique setting for doing so. The continent has experienced repeated glaciations that most models indicate blanketed the continent in ice, yet many Antarctic species appear to have evolved in almost total isolation for millions of years, and hence must have persisted in situ throughout. How could terrestrial species have survived extreme glaciation events on the continent? Under a hypothesis of geothermal glacial refugia and subsequent recolonization of nongeothermal regions, we would expect to find greater contemporary diversity close to geothermal sites than in nongeothermal regions, and significant nestedness by distance of this diversity. We used spatial modeling approaches and the most comprehensive, validated terrestrial biodiversity dataset yet created for Antarctica to assess spatial patterns of diversity on the continent. Models clearly support our hypothesis, indicating that geothermally active regions have played a key role in structuring biodiversity patterns in Antarctica. These results provide critical insights into the evolutionary importance of geothermal refugia and the history of Antarctic species. PMID:24616489

  11. Data Assimilation Approach for Forecast of Solar Activity Cycles

    NASA Astrophysics Data System (ADS)

    Kitiashvili, Irina N.

    2016-11-01

    Numerous attempts to predict future solar cycles are mostly based on empirical relations derived from observations of previous cycles, and they yield a wide range of predicted strengths and durations of the cycles. Results obtained with current dynamo models also deviate strongly from each other, thus raising questions about criteria to quantify the reliability of such predictions. The primary difficulties in modeling future solar activity are shortcomings of both the dynamo models and observations that do not allow us to determine the current and past states of the global solar magnetic structure and its dynamics. Data assimilation is a relatively new approach to develop physics-based predictions and estimate their uncertainties in situations where the physical properties of a system are not well-known. This paper presents an application of the ensemble Kalman filter method for modeling and prediction of solar cycles through use of a low-order nonlinear dynamo model that includes the essential physics and can describe general properties of the sunspot cycles. Despite the simplicity of this model, the data assimilation approach provides reasonable estimates for the strengths of future solar cycles. In particular, the prediction of Cycle 24 calculated and published in 2008 is so far holding up quite well. In this paper, I will present my first attempt to predict Cycle 25 using the data assimilation approach, and discuss the uncertainties of that prediction.

  12. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    SciTech Connect

    Herdiwijaya, Dhani; Arif, Johan; Nurzaman, Muhamad Zamzam; Astuti, Isna Kusuma Dewi

    2015-09-30

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth’s climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth’s global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity.

  13. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    NASA Astrophysics Data System (ADS)

    Herdiwijaya, Dhani; Arif, Johan; Nurzaman, Muhamad Zamzam; Astuti, Isna Kusuma Dewi

    2015-09-01

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth's climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth's global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity.

  14. Plans and Activities for NASA's Global Water Cycle Research

    NASA Astrophysics Data System (ADS)

    Schlosser, C. A.

    2002-05-01

    Strictly speaking, the water (or hydrologic) cycle is by definition a global phenomenon. To observe, analyze, characterize, understand, and predict its structure and variations requires a coordinated, global effort of observations as well as global prediction systems which can assimilate and predict key fluxes and quantities. The National Aeronautics and Space Administration (NASA) has the unique capability of space-based experimental and research measurements that observe the Earth's system as well as core modelling activities to exploit these space-based observations for assimilation in diagnostic studies and initialization in weather and climate predictions. A summary of NASA's current water-cycle activities and implementation plans will be presented. Currently, NASA's Global Water and Energy Cycle and Terrestrial Hydrology (formally known as the Land Surface Hydrology) Programs are the key funding sources which support relevant scientific research. These programs not only fund individual scientists, but also support large-scale field missions (for example the Cold Land Processes Experiment, CLPX, and the Soil Moisture Experiment, SMEx) which are critical for calibration/validation of space instruments and retrievals as well as gaining fundamental understanding of local-scale processes which comprise the global system. In addition, a new initiative for Water and Energy cycle Research (WatER) is being formulated which responds to the recent charge of USGCRP and NRC scientific panels calling for focused and prioritized research plans that serve to make significant strides in our understanding and prediction of the global water cycle. Following NASA's unique vocation, the WatER initative sets priorities for science/research support for key observable quantities of the water cycle (precipitation and surface wetness) whose instrument technology is tactable and scientfic end-returns not only benefit water-cycle predictions, but also serve to benefit other critical

  15. Hierarchical reproductive allocation and allometry within a perennial bunchgrass after 11 years of nutrient addition.

    PubMed

    Tian, Dashuan; Pan, Qingmin; Simmons, Matthew; Chaolu, Hada; Du, Baohong; Bai, Yongfei; Wang, Hong; Han, Xingguo

    2012-01-01

    Bunchgrasses are one of the most important plant functional groups in grassland ecosystems. Reproductive allocation (RA) for a bunchgrass is a hierarchical process; however, how bunchgrasses adjust their RAs along hierarchical levels in response to nutrient addition has never been addressed. Here, utilizing an 11-year nutrient addition experiment, we examined the patterns and variations in RA of Agropyron cristatum at the individual, tiller and spike levels. We evaluated the reproductive allometric relationship at each level by type II regression analysis to determine size-dependent and size-independent effects on plant RA variations. Our results indicate that the proportion of reproductive individuals in A. cristatum increased significantly after 11 years of nutrient addition. Adjustments in RA in A. cristatum were mainly occurred at the individual and tiller levels but not at the spike level. A size-dependent effect was a dominant mechanism underlying the changes in plant RA at both individual and tiller levels. Likewise, the distribution of plant size was markedly changed with large individuals increasing after nutrient addition. Tiller-level RA may be a limiting factor for the adjustment of RA in A. cristatum. To the best of our knowledge, this study is the first to examine plant responses in terms of reproductive allocation and allometry to nutrient enrichment within a bunchgrass population from a hierarchical view. Our findings have important implications for understanding the mechanisms underlying bunchgrass responses in RA to future eutrophication due to human activities. In addition, we developed a hierarchical analysis method for disentangling the mechanisms that lead to variation in RA for perennial bunchgrasses.

  16. The onset of the solar active cycle 22

    NASA Technical Reports Server (NTRS)

    Ahluwalia, H. S.

    1989-01-01

    There is a great deal of interest in being able to predict the main characteristics of a solar activity cycle (SAC). One would like to know, for instance, how large the amplitude (R sub m) of a cycle is likely to be, i.e., the annual mean of the sunspot numbers at the maximum of SAC. Also, how long a cycle is likely to last, i.e., its period. It would also be interesting to be able to predict the details, like how steep the ascending phase of a cycle is likely to be. Questions like these are of practical importance to NASA in planning the launch schedule for the low altitude, expensive spacecrafts like the Hubble Space Telescope, the Space Station, etc. Also, one has to choose a proper orbit, so that once launched the threat of an atmospheric drag on the spacecraft is properly taken into account. Cosmic ray data seem to indicate that solar activity cycle 22 will surpass SAC 21 in activity. The value of R sub m for SAC 22 may approach that of SAC 19. It would be interesting to see whether this prediction is borne out. Researchers are greatly encouraged to proceed with the development of a comprehensive prediction model which includes information provided by cosmic ray data.

  17. MAGNETIC ACTIVITY CYCLES IN THE EXOPLANET HOST STAR {epsilon} ERIDANI

    SciTech Connect

    Metcalfe, T. S.; Mathur, S.; Buccino, A. P.; Mauas, P. J. D.; Petrucci, R.; Brown, B. P.; Soderblom, D. R.; Henry, T. J.; Hall, J. C.; Basu, S.

    2013-02-01

    The active K2 dwarf {epsilon} Eri has been extensively characterized both as a young solar analog and more recently as an exoplanet host star. As one of the nearest and brightest stars in the sky, it provides an unparalleled opportunity to constrain stellar dynamo theory beyond the Sun. We confirm and document the 3-year magnetic activity cycle in {epsilon} Eri originally reported by Hatzes and coworkers, and we examine the archival data from previous observations spanning 45 years. The data show coexisting 3-year and 13-year periods leading into a broad activity minimum that resembles a Maunder minimum-like state, followed by the resurgence of a coherent 3-year cycle. The nearly continuous activity record suggests the simultaneous operation of two stellar dynamos with cycle periods of 2.95 {+-} 0.03 years and 12.7 {+-} 0.3 years, which, by analogy with the solar case, suggests a revised identification of the dynamo mechanisms that are responsible for the so-called 'active' and 'inactive' sequences as proposed by Boehm-Vitense. Finally, based on the observed properties of {epsilon} Eri, we argue that the rotational history of the Sun is what makes it an outlier in the context of magnetic cycles observed in other stars (as also suggested by its Li depletion), and that a Jovian-mass companion cannot be the universal explanation for the solar peculiarities.

  18. Predicting the Sunspot Cycle

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.

    2009-01-01

    The 11-year sunspot cycle was discovered by an amateur astronomer in 1844. Visual and photographic observations of sunspots have been made by both amateurs and professionals over the last 400 years. These observations provide key statistical information about the sunspot cycle that do allow for predictions of future activity. However, sunspots and the sunspot cycle are magnetic in nature. For the last 100 years these magnetic measurements have been acquired and used exclusively by professional astronomers to gain new information about the nature of the solar activity cycle. Recently, magnetic dynamo models have evolved to the stage where they can assimilate past data and provide predictions. With the advent of the Internet and open data policies, amateurs now have equal access to the same data used by professionals and equal opportunities to contribute (but, alas, without pay). This talk will describe some of the more useful prediction techniques and reveal what they say about the intensity of the upcoming sunspot cycle.

  19. Focusing pharmacoeconomic activities: reimbursement or the drug life cycle?

    PubMed

    Langley, Paul C

    2004-01-01

    The purpose of this paper is to consider the role of pharmacoeconomic activities in the drug life cycle and not just as activities to support reimbursement applications and market entry. These activities are important in establishing the value case for a drug product to both internal and external audiences. Unless these activities are fully integrated into establishing the business case for a product from the pre-phase I period of drug discovery, manufacturers run the risk of establishing a unit price for the product and claims for cost-effectiveness which are inconsistent with achieving reimbursement. Importantly, manufacturers need to consider at an early stage the evidentiary and analytical needs for product evaluation under formulary submission guidelines (AMCP; NICE) and the integration of pharmacoeconomic activities over the life cycle. These activities include justifying assumptions for business opportunity assessments and an early commitment to developing a mock reimbursement submission at post-phase II. The integration of pharmacoeconomic activities in the drug cycle is not only an antidote to excessive clinical optimism but also provides the basis for an effective assessment of the likely performance of new products in the health-care market place at a price and formulary position acceptable both to the manufacturer and the reimburser.

  20. Periods of activity cycles in late-type stars

    NASA Technical Reports Server (NTRS)

    Kliorin, N. I.; Ruzmaykin, A. A.; Sokolov, D. D.

    1983-01-01

    The mean magnetic field dynamo theory is utilized to obtain the qualitative dependence of the period of activity on the angular velocity of rotation for stars with sufficiently extensive convective shells. The dependence of the cycle period on the spectral class is also discussed.

  1. FOC/48 Monthly Activation (camera Section - Cycle 4

    NASA Astrophysics Data System (ADS)

    Miebach, Manfred

    1994-01-01

    This is an FOC engineering program needed to RE-ACTIVATE the FOC/48 detector according to CARD item 3.4.2.1 every 30 days. In order to avoid HV-ON cycles on the Intensifier HV Power Supplies the Camera Section is turned ON ONLY.

  2. A cycling workstation to facilitate physical activity in office settings.

    PubMed

    Elmer, Steven J; Martin, James C

    2014-07-01

    Facilitating physical activity during the workday may help desk-bound workers reduce risks associated with sedentary behavior. We 1) evaluated the efficacy of a cycling workstation to increase energy expenditure while performing a typing task and 2) fabricated a power measurement system to determine the accuracy and reliability of an exercise cycle. Ten individuals performed 10 min trials of sitting while typing (SIT type) and pedaling while typing (PED type). Expired gases were recorded and typing performance was assessed. Metabolic cost during PED type was ∼ 2.5 × greater compared to SIT type (255 ± 14 vs. 100 ± 11 kcal h(-1), P < 0.01). Typing time and number of typing errors did not differ between PED type and SIT type (7.7 ± 1.5 vs. 7.6 ± 1.6 min, P = 0.51, 3.3 ± 4.6 vs. 3.8 ± 2.7 errors, P = 0.80). The exercise cycle overestimated power by 14-138% compared to actual power but actual power was reliable (r = 0.998, P < 0.01). A cycling workstation can facilitate physical activity without compromising typing performance. The exercise cycle's inaccuracy could be misleading to users. PMID:24681071

  3. The active RS Canum Venaticorum binary II Pegasi. IV. The SPOT activity cycle

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.; Berdyugin, A. V.; Ilyin, I.; Tuominen, I.

    1999-10-01

    A total of 6 new surface images of II Peg obtained for the years 1997 and 1998 confirms the recently revealed permanent active longitude structure. The lower limit of the active longitudes' lifetime is now extended up to 25 years. A new ``flip-flop'' phenomenon, redefined as a switch of the activity between the active longitudes, has started in summer of 1998. It coincides reasonably well with the moment predicted from the activity cycle of the star. This confirms definitely the cyclic behaviour of the activity of II Peg we recently discovered. Therefore, we assign numbers to the cycles of 4.65 yr since the earliest photoelectric observations of II Peg and define the active longitudes as ``odd'' and ``even'' corresponding to odd and even numbers of cycles. With such a definition, in late 1998 the 7th cycle began and the ``odd'' active longitude became more active. From the analysis of the spot area evolution within the active longitudes we conclude that the activity cycle is developed as a rearrangement of the nearly constant amount of the spot area between the active longitudes. We discuss the ``flip-flop'' phenomenon as a tracer of stellar activity and the role of the unseen secondary in establishing the cycle. Based on observations collected at the Nordic Optical Telescope (NOT), La Palma, Spain; the 1.25m telescope of the Crimean Astrophysical Observatory, Ukraine; the Phoenix 10 robotic telescope, APT Observatory, Arizona, USA.}

  4. SOLAR ROTATION RATE DURING THE CYCLE 24 MINIMUM IN ACTIVITY

    SciTech Connect

    Antia, H. M.; Basu, Sarbani E-mail: sarbani.basu@yale.ed

    2010-09-01

    The minimum of solar cycle 24 is significantly different from most other minima in terms of its duration as well as its abnormally low levels of activity. Using available helioseismic data that cover epochs from the minimum of cycle 23 to now, we study the differences in the nature of the solar rotation between the minima of cycles 23 and 24. We find that there are significant differences between the rotation rates during the two minima. There are differences in the zonal-flow pattern too. We find that the band of fast rotating region close to the equator bifurcated around 2005 and recombined by 2008. This behavior is different from that during the cycle 23 minimum. By autocorrelating the zonal-flow pattern with a time shift, we find that in terms of solar dynamics, solar cycle 23 lasted for a period of 11.7 years, consistent with the result of Howe et al. (2009). The autocorrelation coefficient also confirms that the zonal-flow pattern penetrates through the convection zone.

  5. Activity Scratchpad Prototype: Simplifying the Rover Activity Planning Cycle

    NASA Technical Reports Server (NTRS)

    Abramyan, Lucy

    2005-01-01

    The Mars Exploration Rover mission depends on the Science Activity Planner as its primary interface to the Spirit and Opportunity Rovers. Scientists alternate between a series of mouse clicks and keyboard inputs to create a set of instructions for the rovers. To accelerate planning by minimizing mouse usage, a rover planning editor should receive the majority of inputted commands from the keyboard. Thorough investigation of the Eclipse platform's Java editor has provided the understanding of the base model for the Activity Scratchpad. Desirable Eclipse features can be mapped to specific rover planning commands, such as auto-completion for activity titles and content assist for target names. A custom editor imitating the Java editor's features was created with an XML parser for experimenting purposes. The prototype editor minimized effort for redundant tasks and significantly improved the visual representation of XML syntax by highlighting keywords, coloring rules, folding projections, and providing hover assist, templates and an outline view of the code.

  6. Somatotype in 6-11-year-old Italian and Estonian schoolchildren.

    PubMed

    Ventrella, A R; Semproli, S; Jürimäe, J; Toselli, S; Claessens, A L; Jürimäe, T; Brasili, P

    2008-01-01

    The study of somatotypes can contribute to the understanding of variability in human body build. The aim of this study was to compare the somatotypes of Italian and Estonian schoolchildren in order to evaluate factors that might lead to variability in somatotypes. The sample consisted of 762 Italian and 366 Estonian children aged 6-11 years. They were somatotyped by the Heath-Carter anthropometric method. Data on organised extra-curricular physical activity and hours of weekly training were also collected. One-way ANOVA was used to evaluate country-related variations of somatotype in each age/sex group, while factorial ANOVA was used to test the influence of country and organised physical activity on the variability of the anthropometric characteristics and somatotype components. There are significant differences in mean somatotypes between the Italian and Estonian children in many age classes and a different constitutional trend in children from the two different countries is observed. The Italian children are more endomorphic and less mesomorphic and ectomorphic than the Estonian children. On the other hand, it emerges from factorial ANOVA, that the somatotype components do not present significant variations related to organised physical activity and to the interaction between the country of origin and sport practice. Moreover, the results of the forward stepwise discriminant analyses show that mesomorphy is the best discriminator between the two countries, followed by ectomorphy. Our findings suggest that the observed differences between Italian and Estonian children could be related mainly to country rather than to the practice of organised physical activity in the two countries.

  7. Eating attitudes in a group of 11-year-old urban South African girls

    PubMed Central

    Petersen, Carmen D; Norris, Shane A; Pettifor, John M; MacKeown, Jenny M

    2009-01-01

    Objectives To explore and describe eating attitudes in early pubertal 11-year-old black and white South African girls in an urban environment undergoing transition. Design The study was designed as a cross-sectional baseline initiative within a longitudinal study. Subjects Two hundred and two subjects were randomly selected; 54 were white and 148 black. Methods Subjects completed questionnaires, and anthropometric measurements were taken. Outcome measures Variables included body mass index (BMI), eating attitudes (EAT score), dietary intake, socio-economic status, pubertal status and level of physical activity. Results As expected, the prevalence rate of abnormal eating attitudes in this group of girls was low (1%). No significant ethnic differences were found in the total EAT scores. White participants displayed greater oral control, while their black peers displayed greater tendencies toward dieting (p = 0.05). Girls who scored higher on the dieting subscale had a larger body size and were more inactive than low dieting scorers (p = 0.05). A relationship between body size measurements and dietary intake was found only in black girls. Traditionally a larger figure is accepted in black culture. However our data suggest a move away from this, indicating acculturation, as awareness of increased body size significantly influenced dieting attitudes. However, scores were within the normal range. Conclusions There is early evidence suggesting the impact of societal transition on young black girls with regard to eating attitudes. Black girls in this age group are adopting Western ideals of beauty and thinness. PMID:20526468

  8. Impact of activation process on fog life cycle

    NASA Astrophysics Data System (ADS)

    Mazoyer, Marie; Burnet, Frédéric; Lac, Christine; Roberts, Greg; Dupont, Jean-Charles; Haeffelin, Martial; Elias, Thierry

    2015-04-01

    Fogs are complex meteorological system dealing with fine scale processes. Subtle interaction between radiative, dynamic, turbulent and microphysic processes can lead to different fog life cycle, which make prediction difficult. The droplets that composed fogs are formed trough the activation of aerosol particles called CCN (cloud condensation nuclei) described by the Köhler theory (Köhler, 1936). The number and distribution of the droplets activated during fog formation is determined by the aerosols particles properties and number and the ambient vapor supersaturation of the atmosphere. In the frame of the PreViBOSS project, an in-situ measurement platform of fog properties at ground level was deployed at SIRTA (Instrumented Site for Atmospheric Remote Sensing Research) during winter 2010 to 2013. Microphysics data supply a detailed characterization of number size spectrum from dry to wet aerosols particles and inform on the abilities of the aerosols particles to act as a CCN. 48 fog events have been studied. Supersaturation critical values and concentrations of CCN have been determined and linked to aerosols properties. The main impact of aerosols size distribution on activation have been pointed out. The study of droplets spectra evolution reveals the major physical processes into fogs and suggests that even if thermodynamic dominates the fog life cycle, activation process seems to have a significant effect. Large eddy simulation of fog run with Meso-NH model allow to explore precisely the interaction between fog physical processes and to quantify activation impact. Supersaturation modelling is a key point, a new pseudo-prognostic scheme (Thouron et al., 2012) is used. Confrontation between a detailed experimental study and three-dimensional fine scale simulation in LES provides an accurate investigation of the impact of activation process on fog life cycle.

  9. The Cell Cycle: An Activity Using Paper Plates to Represent Time Spent in Phases of the Cell Cycle

    ERIC Educational Resources Information Center

    Scherer, Yvette D.

    2014-01-01

    In this activity, students are given the opportunity to combine skills in math and geometry for a biology lesson in the cell cycle. Students utilize the data they collect and analyze from an online onion-root-tip activity to create a paper-plate time clock representing a 24-hour cell cycle. By dividing the paper plate into appropriate phases of…

  10. Short-period Stellar Activity Cycles with Kepler Photometry

    NASA Astrophysics Data System (ADS)

    Arkhypov, Oleksiy V.; Khodachenko, Maxim L.; Lammer, Helmut; Güdel, Manuel; Lüftinger, Theresa; Johnstone, Colin P.

    2015-07-01

    We study the short-periodic component of stellar activity with a cycle period of {P}{cyc}\\lt {10}3 days using the Kepler mission photometry of fast-rotating (1\\lt P\\lt 4 days) stars with spectra of M4V to F3V. Applying the originally developed two non-spectral methods, we measured the effective period of stellar cycles in 462 objects. The obtained results are in accordance with previous measurements by Vida et al. and do not seem to result from a beating effect. The performed measurements of Pcyc cluster in a specific branch that covers the previously unstudied region in the Saar & Brandenburg diagram and connects the branch of inactive stars with the area populated by super-active objects. It is shown that the formation of the discovered branch is due to the α-quenching effect, which saturates the magnetic dynamo and decreases the cycle periods with the increase of the inverted Rossby number. This finding is important in the context of the discussion on catastrophic quenching and other heuristic approximations of the nonlinear α-effect.

  11. The variations of prominence activities during solar cycle

    NASA Astrophysics Data System (ADS)

    Shimojo, Masumi

    The prominence activities (prominence eruption/disappearance) in the solar atmosphere closely relate with the CMEs that cause great influences on heliosphere and magnetosphere. Gopal-swarmy et al. (2003) reported that 72 The Nobeyama Radioheliograph (NoRH) is observing Sun in microwave (17 GHz) since 1992. At a flare, the main component of the microwave from Sun is emitted from non-thermal electrons that are accelerated by flare. On the other hand, the main component of the microwave is thermal emission when Sun is quiet, and a prominence is clearly observed in microwave because there is the prominence on the limb. We developed the automatic prominence activity detection program based on 17 GHz images observed by NoRH, and investigated the variation of the properties of the prominence activities that oc-curred from 1992 to the end of 2009. We found the following results. 1. The variation in the number of prominence activities is similar to that of sunspots during one solar cycle but there are differences between the peak times of prominence activities and sunspots. 2. The frequency distribution as a function of the magnitude of the prominence activities the size of activated prominences at each phase shows a power-law distribution. The power-law index of the distribution does not change except around the solar minimum. 3. The number of promi-nence activities has a dependence on the latitude On the other hand the average magnitude is independent of the latitude. In the paper, we will also discuss the relationship the other properties of prominence eruptions, solar cycle and the photospheric magnetic field.

  12. Ethanol Metabolism Activates Cell Cycle Checkpoint Kinase, Chk2

    PubMed Central

    Clemens, Dahn L.; Mahan Schneider, Katrina J.; Nuss, Robert F.

    2011-01-01

    Chronic ethanol abuse results in hepatocyte injury and impairs hepatocyte replication. We have previously shown that ethanol metabolism results in cell cycle arrest at the G2/M transition, which is partially mediated by inhibitory phosphorylation of the cyclin-dependent kinase, Cdc2. To further delineate the mechanisms by which ethanol metabolism mediates this G2/M arrest, we investigated the involvement of upstream regulators of Cdc2 activity. Cdc2 is activated by the phosphatase Cdc25C. The activity of Cdc25C can, in turn, be regulated by the checkpoint kinase, Chk2, which is regulated by the kinase ataxia telangiectasia mutated (ATM). To investigate the involvement of these regulators of Cdc2 activity, VA-13 cells, which are Hep G2 cells modified to efficiently express alcohol dehydrogenase, were cultured in the presence or absence of 25 mM ethanol. Immunoblots were performed to determine the effects of ethanol metabolism on the activation of Cdc25C, Chk2, and ATM. Ethanol metabolism increased the active forms of ATM, and Chk2, as well as the phosphorylated form of Cdc25C. Additionally, inhibition of ATM resulted in approximately 50% of the cells being rescued from the G2/M cell cycle arrest, and ameliorated the inhibitory phosphorylation of Cdc2. Our findings demonstrate that ethanol metabolism activates ATM. ATM can activate the checkpoint kinase Chk2, resulting in phosphorylation of Cdc25C, and ultimately in the accumulation of inactive Cdc2. This may, in part, explain the ethanol metabolism-mediated impairment in hepatocyte replication, which may be important in the initiation and progression of alcoholic liver injury. PMID:21924579

  13. Numerical Analysis of an Active Magnetic Regenerator (AMR) Refrigeration Cycle

    NASA Astrophysics Data System (ADS)

    Dikeos, J.; Rowe, A.; Tura, A.

    2006-04-01

    An alternative cycle proposed for refrigeration and gas liquefaction is active magnetic regenerator (AMR) refrigeration. This technology relies on solid materials exhibiting the magnetocaloric effect (MCE), a nearly reversible temperature change induced by a magnetic field change. This work focuses on numerical simulations of the AMR refrigeration cycle. A transient one-dimensional finite element model developed in FEMLAB™ incorporates energy equations for the refrigerant and the heat transfer fluid. The results of the model are validated by comparison to room temperature experiments with Gd. Predictions are then made for the performance of DyAl2 AMR beds near 70 K. Numerical results for simulations significantly above the Curie temperature are found to be dependent upon the initial conditions.

  14. EEG activity during estral cycle in the rat.

    PubMed

    Corsi-Cabrera, M; Juárez, J; Ponce-de-León, M; Ramos, J; Velázquez, P N

    1992-10-01

    EEG activity was recorded from right and left parietal cortex in adult female rats daily during 6 days. Immediately after EEG recording vaginal smears were taken and were microscopically analyzed to determine the estral stage. Absolute and relative powers and interhemispheric correlation of EEG activity were calculated and compared between estral stages. Interhemispheric correlation was significantly lower during diestrous as compared to proestrous and estrous. Absolute and relative powers did not show significant differences between estral stages. Absolute powers of alpha1, alpha2, beta1 and beta2 bands were significantly higher at the right parietal cortex. Comparisons of the same EEG records with estral stages randomly grouped showed no significant differences for any of the EEG parameters. EEG activity is a sensitive tool to study functional changes related to the estral cycle.

  15. Effects of long-period solar activity fluctuation on temperature and pressure of the terrestrial atmosphere

    NASA Technical Reports Server (NTRS)

    Rubashev, B. M.

    1978-01-01

    The present state of research on the influence of solar sunspot activity on tropospheric temperature and pressure is reviewed. The existence of an 11-year temperature cycle of 5 different types is affirmed. A cyclic change in atmospheric pressure, deducing characteristic changes between 11-year cycles is discussed. The existence of 80-year and 5-to-6-year cycles of temperature is established, and physical causes for birth are suggested.

  16. Sunspot Activity Near Cycle Minimum and What it Might Suggest for Cycle 24, the Next Sunspot Cycle

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2009-01-01

    In late 2008, 12-month moving averages of sunspot number, number of spotless days, number of groups, area of sunspots, and area per group were reflective of sunspot cycle minimum conditions for cycle 24, these values being of or near record value. The first spotless day occurred in January 2004 and the first new-cycle, high-latitude spot was reported in January 2008, although old-cycle, low-latitude spots have continued to be seen through April 2009, yielding an overlap of old and new cycle spots of at least 16 mo. New-cycle spots first became dominant over old-cycle spots in September 2008. The minimum value of the weighted mean latitude of sunspots occurred in May 2007, measuring 6.6 deg, and the minimum value of the highest-latitude spot followed in June 2007, measuring 11.7 deg. A cycle length of at least 150 mo is inferred for cycle 23, making it the longest cycle of the modern era. Based on both the maximum-minimum and amplitude-period relationships, cycle 24 is expected to be only of average to below-average size, peaking probably in late 2012 to early 2013, unless it proves to be a statistical outlier.

  17. Sources of solar wind over the solar activity cycle

    PubMed Central

    Poletto, Giannina

    2012-01-01

    Fast solar wind has been recognized, about 40 years ago, to originate in polar coronal holes (CHs), that, since then, have been identified with sources of recurrent high speed wind streams. As of today, however, there is no general consensus about whether there are, within CHs, preferential locations where the solar wind is accelerated. Knowledge of slow wind sources is far from complete as well. Slow wind observed in situ can be traced back to its solar source by backward extrapolation of magnetic fields whose field lines are streamlines of the outflowing plasma. However, this technique often has not the necessary precision for an indisputable identification of the region where wind originates. As the Sun progresses through its activity cycle, different wind sources prevail and contribute to filling the heliosphere. Our present knowledge of different wind sources is here summarized. Also, a Section addresses the problem of wind acceleration in the low corona, as inferred from an analysis of UV data, and illustrates changes between fast and slow wind profiles and possible signatures of changes along the solar cycle. A brief reference to recent work about the deep roots of solar wind and their changes over different solar cycles concludes the review. PMID:25685421

  18. Sources of solar wind over the solar activity cycle.

    PubMed

    Poletto, Giannina

    2013-05-01

    Fast solar wind has been recognized, about 40 years ago, to originate in polar coronal holes (CHs), that, since then, have been identified with sources of recurrent high speed wind streams. As of today, however, there is no general consensus about whether there are, within CHs, preferential locations where the solar wind is accelerated. Knowledge of slow wind sources is far from complete as well. Slow wind observed in situ can be traced back to its solar source by backward extrapolation of magnetic fields whose field lines are streamlines of the outflowing plasma. However, this technique often has not the necessary precision for an indisputable identification of the region where wind originates. As the Sun progresses through its activity cycle, different wind sources prevail and contribute to filling the heliosphere. Our present knowledge of different wind sources is here summarized. Also, a Section addresses the problem of wind acceleration in the low corona, as inferred from an analysis of UV data, and illustrates changes between fast and slow wind profiles and possible signatures of changes along the solar cycle. A brief reference to recent work about the deep roots of solar wind and their changes over different solar cycles concludes the review.

  19. Responsiveness and functional connectivity of the scene-sensitive retrosplenial complex in 7-11-year-old children.

    PubMed

    Jiang, Ping; Tokariev, Maksym; Aronen, Eeva T; Salonen, Oili; Ma, YuanYe; Vuontela, Virve; Carlson, Synnöve

    2014-10-29

    Brain imaging studies have identified two cortical areas, the parahippocampal place area (PPA) and the retrosplenial complex (RSC), that respond preferentially to the viewing of scenes. Contrary to the PPA, little is known about the functional maturation and cognitive control of the RSC. Here we used functional magnetic resonance imaging and tasks that required attention to scene (or face) images and suppression of face (or scene) images, respectively, to investigate task-dependent modulation of activity in the RSC and whole-brain functional connectivity (FC) of this area in 7-11-year-old children and young adults. We compared responsiveness of the RSC with that of the PPA. The RSC was selectively activated by scene images in both groups, albeit less than the PPA. Children modulated activity between the tasks similarly in the RSC and PPA, and to the same extent as adults in PPA, whereas adults modulated activity in the RSC less than in PPA. In children, the whole brain FC of the RSC was stronger in the Sf than Fs task between the left RSC and right fusiform gyrus. The between groups comparison suggested stronger FC in children than adults in the Sf task between the right RSC and the left inferior parietal lobule and intraparietal sulcus. Together the results suggest that the function of the RSC and the related networks undergo dynamic changes over the development from 7-11-year-old children to adulthood.

  20. Trauma, mental health, and intergenerational associations in Kosovar Families 11 years after the war

    PubMed Central

    Schick, Matthis; Morina, Naser; Klaghofer, Richard; Schnyder, Ulrich; Müller, Julia

    2013-01-01

    Background While there is a considerable amount of literature addressing consequences of trauma in veterans and holocaust survivors, war and postwar civilian populations, particularly children, are still understudied. Evidence regarding intergenerational effects of trauma in families is inconsistent. Objective To shed light on intergenerational aspects of trauma-related mental health problems among families 11 years after the Kosovo war. Method In a cross-sectional study, a paired sample of 51 randomly selected triplets (school-aged child, mother, father, N=153) of Kosovar families was investigated with regard to trauma exposure, posttraumatic stress (UCLA Posttraumatic Diagnostic Scale), anxiety (Spence Children's Anxiety Scale, Hopkins Symptom Checklist-25), and depressive symptoms (Depressionsinventar für Kinder und Jugendliche [DIKJ; depression inventory for children and adolescents], Hopkins Symptom Checklist-25). Results Considerable trauma exposure and high prevalence rates of clinically relevant posttraumatic stress, anxiety, and depressive symptoms were found in both parents and children. While strong correlations were found between children's depressive symptoms and paternal posttraumatic stress, anxiety and depressive symptoms, maternal symptoms did not correlate with their children's. In multiple regression analyses, only posttraumatic stress symptoms of fathers were significantly related with children's depressive symptoms. Conclusion Eleven years after the Kosovo war, the presence of posttraumatic stress, anxiety, and depressive symptoms in civilian adults and their children is still substantial. As symptoms of parents and children are associated, mental health problems of close ones should be actively screened and accounted for in comprehensive treatment plans, using a systemic approach. Future research should include longitudinal studies conducting multivariate analyses with larger sample sizes in order to investigate indicators, causal and

  1. Duration, Distance, and Speed Judgments of Two Moving Objects by 4- to 11-Year-Olds.

    ERIC Educational Resources Information Center

    Matsuda, Fumiko

    1996-01-01

    Four- to 11-year-olds made duration, distance, and speed judgments on Piagetian tasks where cars ran on parallel tracks. Among younger children, duration and distance judgments had approximately the same difficulty. Among older children, distance judgments were easier than duration judgments, and symmetry of effects of temporal and spatial…

  2. Persistence of Challenging Behaviours in Adults with Intellectual Disability over a Period of 11 Years

    ERIC Educational Resources Information Center

    Totsika, V.; Toogood, S.; Hastings, R. P.; Lewis, S.

    2008-01-01

    Background: Challenging behaviours in people with an intellectual disability (ID) often develop early and tend to persist throughout life. This study presents data on the chronicity of challenging behaviours in adults with ID over a period of 11 years, and explores the characteristics of people with persistent serious behaviour problems. Method:…

  3. Race and Ethnicity: An 11-Year Content Analysis of "Counseling and Values"

    ERIC Educational Resources Information Center

    Baker, Caroline A.; Bowen, Nikol V.; Butler, J. Yasmine; Shavers, Marjorie C.

    2013-01-01

    Using the Dimensions of Personal Identity Model proposed by Arredondo and Glauner (as cited in Arredondo et al., 1996), the authors reviewed the last 11 years of the Association for Spiritual, Ethical, and Religious Values in Counseling's journal, "Counseling and Values", specifically regarding the "A" dimensions of race and ethnicity. Twenty-five…

  4. Korean 4- to 11-Year-Old Student Conceptions of Heat and Temperature

    ERIC Educational Resources Information Center

    Paik, Seoung-Hey; Cho, Boo-Kyung; Go, Young-Mi

    2007-01-01

    The aim of the present study is to shed light on the conceptions that young students have of heat and temperature, concepts that are both important in school science curricula and closely related to daily life. The subjects of the study were students from a rural district in South Korea and they ranged in age from 4 to 11 years. Interviews were…

  5. Easy Growth Experiment on Peas Stimulates Interest in Biology for 10-11 Year Old Pupils

    ERIC Educational Resources Information Center

    McEwen, Birgitta

    2007-01-01

    How do we support the enthusiasm children show for biology in school? Unfortunately, lack of exciting practical work and boring biology lessons seem to make science less popular. As a senior lecturer in plant physiology at Karlstad University I have simplified experiments intended for students at university and then tested them on 10-11 year old…

  6. Basic Facts about Low-Income Children: Children 6 through 11 Years, 2013. Fact Sheet

    ERIC Educational Resources Information Center

    Jiang, Yang; Ekono, Mercedes; Skinner, Curtis

    2015-01-01

    Children under 18 years represent 23 percent of the population, but they comprise 33 percent of all people in poverty. Among all children, 44 percent live in low-income families and approximately one in every five (22 percent) live in poor families. Similarly, among children in middle childhood (age 6 through 11 years), 45 percent live in…

  7. [A case of porphyria cutanea tarda in an 11-year-old boy].

    PubMed

    Pindycka-Piaszczyńska, M; Danik, E; Bendkowski, W

    1995-06-01

    A rare case of porphyria cutanea tarda (PCT) in an 11-year-old boy is presented. The clinical manifestations were typical. Results of porphyrin analyses of urine and serum with a fluorescence emission maximum around 398 nm revealed a pattern consistent with PCT. PMID:8692611

  8. Meaning-Making with Colour in Multimodal Texts: An 11-Year-Old Student's Purposeful "Doing"

    ERIC Educational Resources Information Center

    Pantaleo, Sylvia

    2012-01-01

    Colour, a visual element of art and design, is a semiotic mode that is used strategically by sign-makers to communicate meaning. Understanding the meaning-making potential of colour can enhance students' understanding, appreciation, interpretation and composition of multimodal texts. This article features a case study of Anya, an 11-year-old…

  9. Genipin as a novel chemical activator of EBV lytic cycle.

    PubMed

    Son, Myoungki; Lee, Minjung; Ryu, Eunhyun; Moon, Aree; Jeong, Choon-Sik; Jung, Yong Woo; Park, Gyu Hwan; Sung, Gi-Ho; Cho, Hyosun; Kang, Hyojeung

    2015-02-01

    Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt's lymphoma, nasopharyngeal and gastric carcinoma. Antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. Most antiviral agents affect actively replicating viruses, but not their latent forms. Novel antiviral agents must be active on both the replicating and the latent forms of the virus. Gardenia jasminoides is an evergreen flowering plant belonging to the Rubiaceae family and is most commonly found growing wild in Vietnam, Southern China, Taiwan, Japan, Myanmar, and India. Genipin is an aglycone derived from an iridoid glycoside called geniposide, which is present in large quantities in the fruit of G. jasminoides. In this study, genipin was evaluated for its role as an antitumor and antiviral agent that produces inhibitory effects against EBV and EBV associated gastric carcinoma (EBVaGC). In SNU719 cells, one of EBVaGCs, genipin caused significant cytotoxicity (70 μM), induced methylation on EBV C promoter and tumor suppressor gene BCL7A, arrested cell-cycle progress (S phases), upregulated EBV latent/lytic genes in a dose-dependent manner, stimulated EBV progeny production, activated EBV F promoter for EBV lytic activation, and suppressed EBV infection. These results indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC. PMID:25626372

  10. Effects of Low Activity Solar Cycle on Orbital Debris Lifetime

    NASA Technical Reports Server (NTRS)

    Cable, Samual B.; Sutton, Eric K.; Lin, chin S.; Liou, J.-C.

    2011-01-01

    Long duration of low solar activity in the last solar minimum has an undesirable consequence of extending the lifetime of orbital debris. The AFRL TacSat-2 satellite decommissioned in 2008 has finally re-entered into the atmosphere on February 5th after more than one year overdue. Concerning its demise we have monitored its orbital decay and monthly forecasted Tacsat-2 re-entry since September 2010 by using the Orbital Element Prediction (OEP) model developed by the AFRL Orbital Drag Environment program. The model combines estimates of future solar activity with neutral density models, drag coefficient models, and an orbit propagator to predict satellite lifetime. We run the OEP model with solar indices forecast by the NASA Marshall Solar Activity Future Estimation model, and neutral density forecast by the MSIS-00 neutral density model. Based on the two line elements in 2010 up to mid September, we estimated at a 50% confidence level TacSat-2's re-entry time to be in early February 2011, which turned out to be in good agreement with Tacsat-2's actual re-entry date. The potential space weather effects of the coming low activity solar cycle on satellite lifetime and orbital debris population are examined. The NASA long-term orbital debris evolutionary model, LEGEND, is used to quantify the effects of solar flux on the orbital debris population in the 200-600 km altitude environment. The results are discussed for developing satellite orbital drag application product.

  11. Genipin as a novel chemical activator of EBV lytic cycle.

    PubMed

    Son, Myoungki; Lee, Minjung; Ryu, Eunhyun; Moon, Aree; Jeong, Choon-Sik; Jung, Yong Woo; Park, Gyu Hwan; Sung, Gi-Ho; Cho, Hyosun; Kang, Hyojeung

    2015-02-01

    Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt's lymphoma, nasopharyngeal and gastric carcinoma. Antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. Most antiviral agents affect actively replicating viruses, but not their latent forms. Novel antiviral agents must be active on both the replicating and the latent forms of the virus. Gardenia jasminoides is an evergreen flowering plant belonging to the Rubiaceae family and is most commonly found growing wild in Vietnam, Southern China, Taiwan, Japan, Myanmar, and India. Genipin is an aglycone derived from an iridoid glycoside called geniposide, which is present in large quantities in the fruit of G. jasminoides. In this study, genipin was evaluated for its role as an antitumor and antiviral agent that produces inhibitory effects against EBV and EBV associated gastric carcinoma (EBVaGC). In SNU719 cells, one of EBVaGCs, genipin caused significant cytotoxicity (70 μM), induced methylation on EBV C promoter and tumor suppressor gene BCL7A, arrested cell-cycle progress (S phases), upregulated EBV latent/lytic genes in a dose-dependent manner, stimulated EBV progeny production, activated EBV F promoter for EBV lytic activation, and suppressed EBV infection. These results indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC.

  12. Solar wind and coronal rotation during an activity cycle

    NASA Astrophysics Data System (ADS)

    Pinto, Rui; Brun, Allan Sacha

    The properties of the solar wind flow are strongly affected by the time-varying strength and geometry of the global background magnetic field. The wind velocity and mass flux depend directly on the size and position of the wind sources at the surface, and on the geometry of the magnetic flux-tubes along which the wind flows. We address these problems by performing numerical simulations coupling a kinematic dynamo code (STELEM) evolve in a 2.5D axisymmetric coronal MHD code (DIP) covering an 11 yr activity cycle. The latitudinal distribution of the calculated wind velocities agrees with in-situ (ULYSSES, HELIO) and radio measurements (IPS). The transition from fast to slow wind flows can be explained in terms of the high overall flux-tube superradial expansion factors in the vicinities of coronal streamer boundaries. We found that the Alfvén radii and the global Sun's mass loss rate vary considerably throughout the cycle (by a factor 4.5 and 1.6, respectively), leading to strong temporal modulations of the global angular momentum flux and magnetic braking torque. The slowly varying magnetic topology introduces strong non-uniformities in the coronal rotation rate in the first few solar radii. Finally, we point out directions to assess the effects of surface transient phenomena on the global properties of the solar wind.

  13. Global changes in biogeochemical cycles in response to human activities

    NASA Technical Reports Server (NTRS)

    Moore, Berrien, III; Melillo, Jerry

    1994-01-01

    The main objective of our research was to characterize biogeochemical cycles at continental and global scales in both terrestrial and aquatic ecosystems. This characterization applied to both natural ecosystems and those disturbed by human activity. The primary elements of interest were carbon and nitrogen and the analysis sought to quantify standing stocks and dynamic cycling processes. The translocation of major nutrients from the terrestrial landscape to the atmosphere (via trace gases) and to fluvial systems (via leaching, erosional losses, and point source pollution) were of particular importance to this study. Our aim was to develop the first generation of Earth System Models. Our research was organized around the construction and testing of component biogeochemical models which treated terrestrial ecosystem processes, aquatic nutrient transport through drainage basins, and trace gas exchanges at the continental and global scale. A suite of three complementary models were defined within this construct. The models were organized to operate at a 1/2 degree latitude by longitude level of spatial resolution and to execute at a monthly time step. This discretization afforded us the opportunity to understand the dynamics of the biosphere down to subregional scales, while simultaneously placing these dynamics into a global context.

  14. Intertwined arbovirus transmission activity: reassessing the transmission cycle paradigm

    PubMed Central

    Diaz, Luis A.; Flores, Fernando S.; Quaglia, Agustín; Contigiani, Marta S.

    2013-01-01

    Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenomenon. Arboviruses are maintained by biologic transmission among vectors and hosts. Sometimes this biological transmission is specific and includes one vector and host species such as Chikungunya (CHIKV), Dengue (DENV), and urban Yellow Fever (YFV). However, most of the arboviruses are generalist and they use many vectors and hosts species. From this perspective, arboviruses are maintained through a transmission network rather than a transmission cycle. This allows us to understand the complexity and dynamics of the transmission and maintenance of arboviruses in the ecosystems. The old perspective that arboviruses are maintained in close and stable transmission cycles should be modified by a new more integrative and dynamic idea, representing the real scenario where biological interactions have a much broader representation, indicating the constant adaptability of the biological entities. PMID:23335900

  15. A New Simple Dynamo Model for Stellar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Yokoi, N.; Schmitt, D.; Pipin, V.; Hamba, F.

    2016-06-01

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous flow effect on turbulence, it is shown that turbulent cross helicity (velocity-magnetic-field correlation) enters the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. This makes the present model different from the current α-Ω-type models in two main ways. First, in addition to the usual helicity (α) and turbulent magnetic diffusivity (β) effects, we consider the cross-helicity effect as a key ingredient of the dynamo process. Second, the spatiotemporal evolution of cross helicity is solved simultaneously with the mean magnetic fields. The basic scenario is as follows. In the presence of turbulent cross helicity, the toroidal field is induced by the toroidal rotation. Then, as in usual models, the α effect generates the poloidal field from the toroidal one. This induced poloidal field produces a turbulent cross helicity whose sign is opposite to the original one (negative production). With this cross helicity of the reversed sign, a reversal in field configuration starts. Eigenvalue analyses of the simplest possible model give a butterfly diagram, which confirms the above scenario and the equatorward migrations, the phase relationship between the cross helicity and magnetic fields. These results suggest that the oscillation of the turbulent cross helicity is a key for the activity cycle. The reversal of the cross helicity is not the result of the magnetic-field reversal, but the cause of the latter. This new model is expected to open up the possibility of the mean-field or turbulence closure dynamo approaches.

  16. A New Simple Dynamo Model for Stellar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Yokoi, N.; Schmitt, D.; Pipin, V.; Hamba, F.

    2016-06-01

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous flow effect on turbulence, it is shown that turbulent cross helicity (velocity–magnetic-field correlation) enters the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. This makes the present model different from the current α–Ω-type models in two main ways. First, in addition to the usual helicity (α) and turbulent magnetic diffusivity (β) effects, we consider the cross-helicity effect as a key ingredient of the dynamo process. Second, the spatiotemporal evolution of cross helicity is solved simultaneously with the mean magnetic fields. The basic scenario is as follows. In the presence of turbulent cross helicity, the toroidal field is induced by the toroidal rotation. Then, as in usual models, the α effect generates the poloidal field from the toroidal one. This induced poloidal field produces a turbulent cross helicity whose sign is opposite to the original one (negative production). With this cross helicity of the reversed sign, a reversal in field configuration starts. Eigenvalue analyses of the simplest possible model give a butterfly diagram, which confirms the above scenario and the equatorward migrations, the phase relationship between the cross helicity and magnetic fields. These results suggest that the oscillation of the turbulent cross helicity is a key for the activity cycle. The reversal of the cross helicity is not the result of the magnetic-field reversal, but the cause of the latter. This new model is expected to open up the possibility of the mean-field or turbulence closure dynamo approaches.

  17. [Suppression of cycling activity in sheep using parenteral progestagen treatment].

    PubMed

    Janett, F; Camponovo, L; Lanker, U; Hässig, M; Thun, R

    2004-03-01

    The objective of this study was to evaluate the effect of two synthetic progestagen preparations Chlormadinone acetate (CAP, Chronosyn, Veterinaria AG Zürich) and Medroxyprogesterone acetate (MPA, Nadigest, G Streuli & Co. Uznach) on cycling activity and fertility in sheep. A flock of 28 non pregnant white alpine sheep was randomly divided into three groups, A (n = 10), B (n = 9) and C (n = 9). During a period of 4 weeks the cycling activity was confirmed by blood progesterone analysis. Thereafter, the animals of group A were treated with 50 mg CAP, those of group B with 140 mg MPA and those of group C with physiological saline solution. All injections were given intramuscularly. Suppression of endogenous progesterone secretion lasted from 28 to 49 days (mean = 39 days) in group A and from 42 to 70 days (mean = 50 days) in group B. The synchronization effect of both preparations was unsatisfactory as the occurrence of first estrus was distributed over a period of 3 weeks in group A and 4 weeks in group B. These findings could also be confirmed by the lambing period which lasted 52 days in group A and 36 days in group B. Control animals lambed within 9 days due to the synchronizing effect of the ram. The first fertile estrus was observed 36 days (group A) and 45 days (group B) after the treatment. In group A all 10 animals and in groups B and C 8 of 9 ewes each became pregnant. Parenteral progestagen application with CAP and MPA is a simple, safe and reversible method of estrus suppression in the sheep. The minimal suppressive duration of 4 (CAP) and 5 weeks (MPA) is not sufficient when a period of 3 months (alpine pasture period) is desired.

  18. Does age at first treatment episode make a difference in outcomes over 11 years?

    PubMed

    Chi, Felicia W; Weisner, Constance; Grella, Christine E; Hser, Yih-Ing; Moore, Charles; Mertens, Jennifer

    2014-04-01

    This study examines the associations between age at first substance use treatment entry and trajectory of outcomes over 11 years. We found significant differences in individual and treatment characteristics between adult intakes first treated during young adulthood (25 years or younger) and those first treated at an older age. Compared to their first treated older age counterparts matched on demographics and dependence type, those who entered first treatment during young adulthood had on average an earlier onset for substance use but a shorter duration between first substance use and first treatment entry; they also had worse alcohol and other drug outcomes 11 years post treatment entry. While subsequent substance use treatment and 12-step meeting attendance are important for both age groups in maintaining positive outcomes, relationships varied by age group. Findings underline the importance of different continuing care management strategies for those entering first treatment at different developmental stages. PMID:24462221

  19. FLUOR HANFORD (FH) MAKES CLEANUP A REALITY IN NEARLY 11 YEARS AT HANFORD

    SciTech Connect

    GERBER, M.S.

    2007-05-24

    For nearly 11 years, Fluor Hanford has been busy cleaning up the legacy of nuclear weapons production at one of the Department of Energy's (DOE'S) major sites in the United States. As prime nuclear waste cleanup contractor at the vast Hanford Site in southeastern Washington state, Fluor Hanford has changed the face of cleanup. Fluor beginning on October 1, 1996, Hanford Site cleanup was primarily a ''paper exercise.'' The Tri-Party Agreement, officially called the Hanford Federal Facility Agreement and Consent Order - the edict governing cleanup among the DOE, U.S. Environmental Protection Agency (EPA) and Washington state - was just seven years old. Milestones mandated in the agreement up until then had required mainly waste characterization, reporting, and planning, with actual waste remediation activities off in the future. Real work, accessing waste ''in the field'' - or more literally in huge underground tanks, decaying spent fuel POO{approx}{approx}S, groundwater, hundreds of contaminated facilities, solid waste burial grounds, and liquid waste disposal sites -began in earnest under Fluor Hanford. The fruits of labors initiated, completed and/or underway by Fluor Hanford can today be seen across the site. Spent nuclear fuel is buttoned up in secure, dry containers stored away from regional water resources, reactive plutonium scraps are packaged in approved containers, transuranic (TRU) solid waste is being retrieved from burial trenches and shipped offsite for permanent disposal, contaminated facilities are being demolished, contaminated groundwater is being pumped out of aquifers at record rates, and many other inventive solutions are being applied to Hanford's most intransigent nuclear wastes. (TRU) waste contains more than 100 nanocuries per gram, and contains isotopes higher than uranium on the Periodic Table of the Elements. (A nanocurie is one-billionth of a curie.) At the same time, Fluor Hanford has dramatically improved safety records, and cost

  20. Pemphigus foliaceus in an 11-year-old mexican girl with response to oral dapsone.

    PubMed

    García-Meléndez, Martha Elena; Eichelmann, Kristian; Salas-Alanís, Julio César; Gomez-Flores, Minerva; Ocampo-Candiani, Jorge

    2013-01-01

    Pemphigus foliaceus (PF) is rarely described in the pediatric population with less than 40 cases reported in the literature. We report the case of an 11-year-old girl who was diagnosed with PF after 6 months of starting with symptoms and who responded well to therapy with oral dapsone. Although therapeutic guidelines for PF in children are lacking, oral corticosteroids in combination with dapsone have proven to be effective as first-line treatment in this setting.

  1. Pemphigus Foliaceus in an 11-Year-Old Mexican Girl with Response to Oral Dapsone

    PubMed Central

    García-Meléndez, Martha Elena; Eichelmann, Kristian; Salas-Alanís, Julio César; Gomez-Flores, Minerva; Ocampo-Candiani, Jorge

    2013-01-01

    Pemphigus foliaceus (PF) is rarely described in the pediatric population with less than 40 cases reported in the literature. We report the case of an 11-year-old girl who was diagnosed with PF after 6 months of starting with symptoms and who responded well to therapy with oral dapsone. Although therapeutic guidelines for PF in children are lacking, oral corticosteroids in combination with dapsone have proven to be effective as first-line treatment in this setting. PMID:24416609

  2. The sequence of learning cycle activities in high school chemistry

    NASA Astrophysics Data System (ADS)

    Abraham, Michael R.; Renner, John W.

    The sequence of the three phases of two high school learning cycles in chemistry was altered in order to: (I ) give insights into the factors which account for the success of the learning cycle, (2) serve as an indirect test of the association between Piaget's theory and the learning cycle, and (3) to compare the learning cycle with traditional instruction. Each of the six sequences (one n o d and five altered) was studied with content and atritudc measures. The outcomes of the study supported the contention that the normal learning cycle sequence is the optimum sequence for achievement of content knowledge.

  3. Exercise, physical activity, and exertion over the business cycle.

    PubMed

    Colman, Gregory; Dave, Dhaval

    2013-09-01

    Shifts in time and income constraints over economic expansions and contractions would be expected to affect individuals' behaviors. We explore the impact of the business cycle on individuals' exercise, time use, and total physical exertion, utilizing information on 112,000 individual records from the 2003-2010 American Time Use Surveys. In doing so, we test a key causal link that has been hypothesized in the relation between unemployment and health, but not heretofore assessed. Using more precise measures of exercise (and other activities) than previous studies, we find that as work-time decreases during a recession, recreational exercise, TV-watching, sleeping, childcare, and housework increase. This, however, does not compensate for the decrease in work-related exertion due to job-loss, and total physical exertion declines. These effects are strongest among low-educated men, which is validating given that employment in the Great Recession has declined most within manufacturing, mining, and construction. We also find evidence of intra-household spillover effects, wherein individuals respond to shifts in spousal employment conditional on their own labor supply. The decrease in total physical activity during recessions is especially problematic for vulnerable populations concentrated in boom-and-bust industries, and may have longer-term effects on obesity and related health outcomes.

  4. Exercise, physical activity, and exertion over the business cycle.

    PubMed

    Colman, Gregory; Dave, Dhaval

    2013-09-01

    Shifts in time and income constraints over economic expansions and contractions would be expected to affect individuals' behaviors. We explore the impact of the business cycle on individuals' exercise, time use, and total physical exertion, utilizing information on 112,000 individual records from the 2003-2010 American Time Use Surveys. In doing so, we test a key causal link that has been hypothesized in the relation between unemployment and health, but not heretofore assessed. Using more precise measures of exercise (and other activities) than previous studies, we find that as work-time decreases during a recession, recreational exercise, TV-watching, sleeping, childcare, and housework increase. This, however, does not compensate for the decrease in work-related exertion due to job-loss, and total physical exertion declines. These effects are strongest among low-educated men, which is validating given that employment in the Great Recession has declined most within manufacturing, mining, and construction. We also find evidence of intra-household spillover effects, wherein individuals respond to shifts in spousal employment conditional on their own labor supply. The decrease in total physical activity during recessions is especially problematic for vulnerable populations concentrated in boom-and-bust industries, and may have longer-term effects on obesity and related health outcomes. PMID:23906116

  5. ENZYME ACTIVITIES DURING THE ASEXUAL CYCLE OF NEUROSPORA CRASSA

    PubMed Central

    Stine, G. J.

    1968-01-01

    Three enzymes, (a) nicotinamide adenine diphosphate-dependent glutamic dehydrogenase (NAD enzyme), (b) nictoinamide adenine triphosphate-dependent glutamic dehydrogenase (NADP enzyme), and (c) nicotinamide-adenine dinucleotidase (NADase), were measured in separate extracts of Neurospora crassa grown in Vogel's medium N and medium N + glutamate. Specific activities and total units per culture of each enzyme were determined at nine separate intervals phased throughout the asexual cycle. The separate dehydrogenases were lowest in the conidia, increased slowly during germination, and increased rapidly during logarithmic mycelial growth. The amounts of these enzymes present during germination were small when compared with those found later during the production of the conidiophores. The NAD enzyme may be necessary for pregermination synthesis. The NADP-enzyme synthesis was associated with the appearance of the germ tube. Although higher levels of the dehydrogenases in the conidiophores resulted in more enzyme being found in the differentiated conidia, the rate of germination was uneffected. The greatest activity for the NADase enzyme was associated with the conidia, early phases of germination, and later production of new conidia. NADase decreased significantly with the onset of logarithmic growth, remained low during the differentiation of conidiophores, and increased considerably as the conidiophores aged. PMID:4384627

  6. Long-Range Solar Activity Predictions: A Reprieve from Cycle #24's Activity

    NASA Technical Reports Server (NTRS)

    Richon, K.; Schatten, K.

    2003-01-01

    We discuss the field of long-range solar activity predictions and provide an outlook into future solar activity. Orbital predictions for satellites in Low Earth Orbit (LEO) depend strongly on exospheric densities. Solar activity forecasting is important in this regard, as the solar ultra-violet (UV) and extreme ultraviolet (EUV) radiations inflate the upper atmospheric layers of the Earth, forming the exosphere in which satellites orbit. Rather than concentrate on statistical, or numerical methods, we utilize a class of techniques (precursor methods) which is founded in physical theory. The geomagnetic precursor method was originally developed by the Russian geophysicist, Ohl, using geomagnetic observations to predict future solar activity. It was later extended to solar observations, and placed within the context of physical theory, namely the workings of the Sun s Babcock dynamo. We later expanded the prediction methods with a SOlar Dynamo Amplitude (SODA) index. The SODA index is a measure of the buried solar magnetic flux, using toroidal and poloidal field components. It allows one to predict future solar activity during any phase of the solar cycle, whereas previously, one was restricted to making predictions only at solar minimum. We are encouraged that solar cycle #23's behavior fell closely along our predicted curve, peaking near 192, comparable to the Schatten, Myers and Sofia (1996) forecast of 182+/-30. Cycle #23 extends from 1996 through approximately 2006 or 2007, with cycle #24 starting thereafter. We discuss the current forecast of solar cycle #24, (2006-2016), with a predicted smoothed F10.7 radio flux of 142+/-28 (1-sigma errors). This, we believe, represents a reprieve, in terms of reduced fuel costs, etc., for new satellites to be launched or old satellites (requiring reboosting) which have been placed in LEO. By monitoring the Sun s most deeply rooted magnetic fields; long-range solar activity can be predicted. Although a degree of uncertainty

  7. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation.

    PubMed

    Aram, Lior; Braun, Tslil; Braverman, Carmel; Kaplan, Yosef; Ravid, Liat; Levin-Zaidman, Smadar; Arama, Eli

    2016-04-01

    How cells avoid excessive caspase activity and unwanted cell death during apoptotic caspase-mediated removal of large cellular structures is poorly understood. We investigate caspase-mediated extrusion of spermatid cytoplasmic contents in Drosophila during spermatid individualization. We show that a Krebs cycle component, the ATP-specific form of the succinyl-CoA synthetase β subunit (A-Sβ), binds to and activates the Cullin-3-based ubiquitin ligase (CRL3) complex required for caspase activation in spermatids. In vitro and in vivo evidence suggests that this interaction occurs on the mitochondrial surface, thereby limiting the source of CRL3 complex activation to the vicinity of this organelle and reducing the potential rate of caspase activation by at least 60%. Domain swapping between A-Sβ and the GTP-specific SCSβ (G-Sβ), which functions redundantly in the Krebs cycle, show that the metabolic and structural roles of A-Sβ in spermatids can be uncoupled, highlighting a moonlighting function of this Krebs cycle component in CRL activation.

  8. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation.

    PubMed

    Aram, Lior; Braun, Tslil; Braverman, Carmel; Kaplan, Yosef; Ravid, Liat; Levin-Zaidman, Smadar; Arama, Eli

    2016-04-01

    How cells avoid excessive caspase activity and unwanted cell death during apoptotic caspase-mediated removal of large cellular structures is poorly understood. We investigate caspase-mediated extrusion of spermatid cytoplasmic contents in Drosophila during spermatid individualization. We show that a Krebs cycle component, the ATP-specific form of the succinyl-CoA synthetase β subunit (A-Sβ), binds to and activates the Cullin-3-based ubiquitin ligase (CRL3) complex required for caspase activation in spermatids. In vitro and in vivo evidence suggests that this interaction occurs on the mitochondrial surface, thereby limiting the source of CRL3 complex activation to the vicinity of this organelle and reducing the potential rate of caspase activation by at least 60%. Domain swapping between A-Sβ and the GTP-specific SCSβ (G-Sβ), which functions redundantly in the Krebs cycle, show that the metabolic and structural roles of A-Sβ in spermatids can be uncoupled, highlighting a moonlighting function of this Krebs cycle component in CRL activation. PMID:27052834

  9. Position of the Academy of Nutrition and Dietetics: nutrition guidance for healthy children ages 2 to 11 years.

    PubMed

    Ogata, Beth N; Hayes, Dayle

    2014-08-01

    It is the position of the Academy of Nutrition and Dietetics that children ages 2 to 11 years should achieve optimal physical and cognitive development, maintain healthy weights, enjoy food, and reduce the risk of chronic disease through appropriate eating habits and participation in regular physical activity. Rapid increases in the prevalence of childhood obesity during the 1980s and 1990s focused attention on young children's overconsumption of energy-dense, nutrient-poor foods and beverages and lack of physical activity. While recent data suggest a stabilization of obesity rates, several public health concerns remain. These include the most effective ways to promote healthy weights, the number of children living in food insecurity, the under-consumption of key nutrients, and the early development of diet-related risks for chronic diseases, such as cardiovascular disease, type 2 diabetes, cancer, obesity, and osteoporosis. This Position Paper reviews what children 2 to 11 years old in the United States are reportedly eating, explores trends in food and nutrient intakes, and examines the impact of federal nutrition programs on child nutrition. Current dietary recommendations and guidelines for physical activity are also discussed. The roles of parents and caregivers in influencing the development of life-long healthy eating behaviors are highlighted. The Academy of Nutrition and Dietetics works with other allied health and food industry professionals to translate dietary recommendations and guidelines into positive, practical health messages. Specific recommendations and sources of science-based nutrition messages to improve the nutritional well-being of children are provided for food and nutrition practitioners. PMID:25060139

  10. Position of the Academy of Nutrition and Dietetics: nutrition guidance for healthy children ages 2 to 11 years.

    PubMed

    Ogata, Beth N; Hayes, Dayle

    2014-08-01

    It is the position of the Academy of Nutrition and Dietetics that children ages 2 to 11 years should achieve optimal physical and cognitive development, maintain healthy weights, enjoy food, and reduce the risk of chronic disease through appropriate eating habits and participation in regular physical activity. Rapid increases in the prevalence of childhood obesity during the 1980s and 1990s focused attention on young children's overconsumption of energy-dense, nutrient-poor foods and beverages and lack of physical activity. While recent data suggest a stabilization of obesity rates, several public health concerns remain. These include the most effective ways to promote healthy weights, the number of children living in food insecurity, the under-consumption of key nutrients, and the early development of diet-related risks for chronic diseases, such as cardiovascular disease, type 2 diabetes, cancer, obesity, and osteoporosis. This Position Paper reviews what children 2 to 11 years old in the United States are reportedly eating, explores trends in food and nutrient intakes, and examines the impact of federal nutrition programs on child nutrition. Current dietary recommendations and guidelines for physical activity are also discussed. The roles of parents and caregivers in influencing the development of life-long healthy eating behaviors are highlighted. The Academy of Nutrition and Dietetics works with other allied health and food industry professionals to translate dietary recommendations and guidelines into positive, practical health messages. Specific recommendations and sources of science-based nutrition messages to improve the nutritional well-being of children are provided for food and nutrition practitioners.

  11. Amplification of the Steady Toroidal Magnetic Field in Solar Interior and Asymmetry of Sunspot Activity in Neighbouring Cycles

    NASA Astrophysics Data System (ADS)

    Kryvodubskyj, V. N.

    2006-08-01

    This investigation deals with the problem of the asymmetry of sunspot activity maximums in neighbouring solar cycles. The Gnevyshev-Ohl rule (Gnevyshev and Ohl 1948, Astron. Zhurn. 25, 18) is a likely evidence for the radiative interior pervaded by a strong steady magnetic field. Therefore, some effects are required to ensure existence this deep-laid field for long-duration times. The way for search of excitation mechanism of strong magnetic field gives us the helioseismological experiments. We take the physical parameters of the interiors from standard solar model by Allen (1973, Astrophysical Quantities, London) for calculations. It was found that main limiting factor on the magnetic field value is the magnetic flux loss due to buoyancy in the radiative (non-turbulent) zone (RZ) which overcomes the rate of the field decay caused by ohmic dissipation. The helioseismology inversions indicate that the radial, but not latitudinal, shear in the internal rotation of the Sun penetrates rather deep, almost to the solar core (Duval et al.1984, Nature 310, 22; Brown 1985, Nature 317, 591; Libbrecht 1986, Nature 319, 753). This radial differential rotation, acting on a weak relict poloidal magnetic field, about 1 G, in the stable RZ, can excite the rather strong steady toroidal fields (10 KG - 10 MG). Obtained estimations agree with the helioseismically determined magnetic intensities in the solar interiors (Dziembowski and Goode 1989, ApJ 347, 540; Antia, Chitre and Thompson 2003, A&A 399, 329). We assume that due to magnetic buoyancy and meridional circulation at the upper boundary of the RZ the power toroidal field may penetrate, partly, into the convective zone (CZ). Here stationary steady directed field will be add to oscillating toroidal field excited by αΩ-dynamo. Since the oscillating dynamo-field changes their own direction with 11-years cycle-period, then the amplitude of total, oscillating plus steady, toroidal field in the CZ has to be a few differing in

  12. A Summary of Closed Brayton Cycle Development Activities at NASA

    NASA Technical Reports Server (NTRS)

    Mason, Lee S.

    2009-01-01

    NASA has been involved in the development of Closed Brayton Cycle (CBC) power conversion technology since the 1960's. CBC systems can be coupled to reactor, isotope, or solar heat sources and offer the potential for high efficiency, long life, and scalability to high power. In the 1960's and 1970's, NASA and industry developed the 10 kW Brayton Rotating Unit (BRU) and the 2 kW mini-BRU demonstrating technical feasibility and performance, In the 1980's, a 25 kW CBC Solar Dynamic (SD) power system option was developed for Space Station Freedom and the technology was demonstrated in the 1990's as part of the 2 kW SO Ground Test Demonstration (GTD). Since the early 2000's, NASA has been pursuing CBC technology for space reactor applications. Before it was cancelled, the Jupiter Icy Moons Orbiter (HMO) mission was considering a 100 kWclass CBC system coupled to a gas-cooled fission reactor. Currently, CBC technology is being explored for Fission Surface Power (FSP) systems to provide base power on the moon and Mars. These recent activities have resulted in several CBC-related technology development projects including a 50 kW Alternator Test Unit, a 20 kW Dual Brayton Test Loop, a 2 kW Direct Drive Gas Brayton Test Loop, and a 12 kW FSP Power Conversion Unit design.

  13. Quantifying promoter activity during the developmental cycle of Chlamydia trachomatis

    PubMed Central

    Cong, Yanguang; Gao, Leiqiong; Zhang, Yan; Xian, Yuqi; Hua, Ziyu; Elaasar, Hiba; Shen, Li

    2016-01-01

    Chlamydia trachomatis is an important human pathogen that undergoes a characteristic development cycle correlating with stage-specific gene expression profiles. Taking advantage of recent developments in the genetic transformation in C. trachomatis, we constructed a versatile green fluorescent protein (GFP) reporter system to study the development-dependent function of C. trachomatis promoters in an attempt to elucidate the mechanism that controls C. trachomatis adaptability. We validated the use of the GFP reporter system by visualizing the activity of an early euo gene promoter. Additionally, we uncovered a new ompA promoter, which we named P3, utilizing the GFP reporter system combined with 5′ rapid amplification of cDNA ends (RACE), in vitro transcription assays, real-time quantitative RT-PCR (RT-qPCR), and flow cytometry. Mutagenesis of the P3 region verifies that P3 is a new class of C. trachomatis σ66-dependent promoter, which requires an extended −10 TGn motif for transcription. These results corroborate complex developmentally controlled ompA expression in C. trachomatis. The exploitation of genetically labeled C. trachomatis organisms with P3-driven GFP allows for the observation of changes in ompA expression in response to developmental signals. The results of this study could be used to complement previous findings and to advance understanding of C. trachomatis genetic expression. PMID:27263495

  14. A Solar Cycle Dependence of Nonlinearity in Magnetospheric Activity

    SciTech Connect

    Johnson, Jay R; Wing, Simon

    2005-03-08

    The nonlinear dependencies inherent to the historical K(sub)p data stream (1932-2003) are examined using mutual information and cumulant based cost as discriminating statistics. The discriminating statistics are compared with surrogate data streams that are constructed using the corrected amplitude adjustment Fourier transform (CAAFT) method and capture the linear properties of the original K(sub)p data. Differences are regularly seen in the discriminating statistics a few years prior to solar minima, while no differences are apparent at the time of solar maximum. These results suggest that the dynamics of the magnetosphere tend to be more linear at solar maximum than at solar minimum. The strong nonlinear dependencies tend to peak on a timescale around 40-50 hours and are statistically significant up to one week. Because the solar wind driver variables, VB(sub)s and dynamical pressure exhibit a much shorter decorrelation time for nonlinearities, the results seem to indicate that the nonlinearity is related to internal magnetospheric dynamics. Moreover, the timescales for the nonlinearity seem to be on the same order as that for storm/ring current relaxation. We suggest that the strong solar wind driving that occurs around solar maximum dominates the magnetospheric dynamics suppressing the internal magnetospheric nonlinearity. On the other hand, in the descending phase of the solar cycle just prior to solar minimum, when magnetospheric activity is weaker, the dynamics exhibit a significant nonlinear internal magnetospheric response that may be related to increased solar wind speed.

  15. An international comparison of dietary patterns in 9–11-year-old children

    PubMed Central

    Mikkilä, V; Vepsäläinen, H; Saloheimo, T; Gonzalez, S A; Meisel, J D; Hu, G; Champagne, C M; Chaput, J-P; Church, T S; Katzmarzyk, P T; Kuriyan, R; Kurpad, A; Lambert, E V; Maher, C; Maia, J; Matsudo, V; Olds, T; Onywera, V; Sarmiento, O L; Standage, M; Tremblay, M S; Tudor-Locke, C; Zhao, P; Fogelholm, M

    2015-01-01

    OBJECTIVES: Dietary pattern is defined as a combination of foods and drinks and the frequency of consumption within a population. Dietary patterns are changing on a global level, which may be linked to an increased incidence of chronic diseases. The aim of this study was to identify and compare the dietary patterns among 9–11-year-old children living in urban regions in different parts of the world. METHODS: Participants were 7199 children (54% girls), aged 9–11 years, from 12 countries situated in all major world regions. Food consumption was assessed using a 23-item Food Frequency Questionnaire (FFQ). To identify dietary patterns, principal components analyses (PCA) were carried out using weekly portions as input variables. RESULTS: Both site-specific and pooled PCA resulted in two strong components. Component 1 (‘unhealthy diet pattern') included fast foods, ice cream, fried food, French fries, potato chips, cakes and sugar-sweetened sodas with >0.6 loadings. The loadings for component 2 (‘healthy diet pattern') were slightly weaker with only dark-green vegetables, orange vegetables, vegetables in general, and fruits and berries reaching a >0.6 loading. The site-specific diet pattern scores had very strong correlations with the pattern scores from the pooled data: r=0.82 and 0.94 for components 1 and 2, respectively. CONCULSIONS: The results suggest that the same ‘healthier' and ‘unhealthier' foods tend to be consumed in similar combinations among 9–11-year-old children in different countries, despite variation in food culture, geographical location, ethnic background and economic development. PMID:27152179

  16. Dexa Body Composition Assessment in 10-11 Year Healthy Children

    PubMed Central

    Doodeman, H. J.; Struijf, E.; Houdijk, A. P. J.

    2016-01-01

    Introduction Obesity is a growing health problem associated with metabolic derangements and cardiovascular disease. Accumulating evidence links the accumulation of visceral adipose tissue (VAT) to these obesity related health risks in adults. Childhood obesity is associated with a lifetime risk of cardiovascular disease and poses a serious challenge to future health care. In children, there is much less data on the prevalence and gender differences of visceral obesity than in adults. This study aims to provide reference values for VAT in children 10–11 years of age. Methods In a cross-sectional study performed in the north western part of theNetherlands, healthy children of 10–11 years of age, were recruited from primary schools. Anthropometric data consisting of height, weight, waist circumference (WC) and BMI were measured. Body composition was measured using DXA, providing measures for bone mineral content, total fat mass (TFM), lean body mass (LBM) and VAT. Results 217 children were eligible for this study. Girls appeared to have a greater TFM (31.4% vs 27.5% of total body weight (TBW); P < .01) but lower VAT (0.3% vs 0.5% of TBW;P < .01) than boys, whereas boys had higher LBM (65.4% vs 69.3% TBW;P < .01). Median VAT area (cm2) was 41.1 for boys and 22.4 for girls (P < .01). Moderate to strong correlations were found for WC and BMI with VAT (boys: r = .664 and r = .630; Girls r = .699 and r = .546 respectively all P < .001). Discussion This study shows gender specific differences in VAT percentiles in healthy non-obese 10–11 year old children as measured by DXA that may serve as reference values in children. Independent of BMI and WC, girls tend to have more TFM but less VAT and LBM than boys. PMID:27788168

  17. Isolated ileal ganglioneuromatosis in an 11-year-old boy: Case report and review of literature.

    PubMed

    Mitra, Subhashis; Mukherjee, Sanghamitra; Chakraborty, Hema

    2016-01-01

    Ganglioneuromatous proliferation in the gastrointestinal tract is a rare occurrence and is usually associated with specific syndrome complexes such as multiple endocrine neoplasia Type 2B or von Recklinghausen's disease. We report here a case of diffuse intestinal ganglioneuromatosis, presenting as intestinal obstruction and chronic constipation in an 11-year-old boy. Sporadic cases of intestinal ganglioneuromatosis in the absence of any systemic manifestations are a very rare cause of enteric motility disorders in childhood, and we discuss the pathological and clinical significance of this finding. Histopathological identification of this uncommon cause of a common pediatric problem is important since the condition is amenable to surgical treatment.

  18. An 11-year follow-up of a network of cocaine users.

    PubMed

    Murphy, S B; Reinarman, C; Waldorf, D

    1989-04-01

    This paper presents findings from an exploratory 11-year follow-up study of a small network of cocaine users. These findings suggest that while serious abuse potential exists, addiction is not a uniform outcome of sustained use and that long-term controlled use is possible. In all, four types of career use pattern are described, in addition to one case of regular abuse. These data also suggest the importance of user norms and informal social controls in mitigating against the force of pharmacological and physiological factors leading toward dependence or addiction.

  19. Mask face: bilateral simultaneous facial palsy in an 11-year-old boy.

    PubMed

    Güngör, Serdal; Güngör Raif, Sabiha; Arslan, Müjgan

    2013-04-01

    Bilateral facial paralysis is an uncommon clinical entity especially in the pediatric age group and occurs frequently as a manifestation of systemic disease. The most important causes are trauma, infectious diseases, neurological diseases, metabolic, neoplastic, autoimmune diseases and idiopathic disease (Bell's palsy). We report a case of an 11-year-old boy presenting with bilateral simultaneous peripheral facial paralysis. All possible infectious causes were excluded and the patient was diagnosed as having Bell's palsy (idiopathic). The most important approach in these cases is to rule out a life-threatening disease.

  20. Activities of Tricarboxylic Acid Cycle Enzymes, Glyoxylate Cycle Enzymes, and Fructose Diphosphatase in Bakers' Yeast During Adaptation to Acetate Oxidation

    PubMed Central

    Gosling, J. P.; Duggan, P. F.

    1971-01-01

    Bakers' yeast oxidizes acetate at a high rate only after an adaptation period during which the capacity of the glyoxylate cycle is found to increase. There was apparently no necessity for the activity of acetyl-coenzyme A synthetase, the capacity of the tricarboxylic acid cycle, or the concentrations of the cytochromes to increase for this adaptation to occur. Elevation of fructose 1,6 diphosphatase occurred only when acetate oxidation was nearly maximal. Cycloheximide almost completely inhibited adaptation as well as increases in the activities of isocitrate lyase and aconitate hydratase, the only enzymes assayed. p-Fluorophenylalanine was partially effective and chloramphenicol did not inhibit at all. The presence of ammonium, which considerably delayed adaptation of the yeast to acetate oxidation, inhibited the increases in the activities of the glyoxylate cycle enzymes to different degrees, demonstrating noncoordinate control of these enzymes. Under the various conditions, the only enzyme activity increase consistently related to the rising oxygen uptake rate was that of isocitrate lyase which apparently limited the activity of the cycle. PMID:5557595

  1. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle: science behind the myth.

    PubMed

    Sjödin, A; Hjorth, M F; Damsgaard, C T; Ritz, C; Astrup, A; Michaelsen, K F

    2015-04-01

    Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8-11 years, with more than 13,000 24-h accelerometer recordings of activity and sleep as well as 2000 measurements of different cardiometabolic risk factors, including insulin sensitivity, appetite hormones and blood pressure, during nine lunar phases. During the period around full moon, children were 5.0 and 3.2 min per day less active, slept 2.4 and 4.1 min per night longer, had 0.03 and 0.05 higher homeostatic model assessment of insulin resistance and 0.6 and 0.8 mmHg higher mean arterial blood pressure compared with days around half moon and new moon, respectively (all P ≤ 0.02). Furthermore, ghrelin was lower and leptin was higher during the period around full moon compared with days around half moon (both P < 0.001). The results suggest that physical activity rather than sleep is responsible for the metabolic alterations observed around full moon. However, we have no understanding of potential mechanisms that may mediate a potential true link between childhood behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases.

  2. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle: science behind the myth

    PubMed Central

    Sjödin, A; Hjorth, M F; Damsgaard, C T; Ritz, C; Astrup, A; Michaelsen, K F

    2015-01-01

    Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8–11 years, with more than 13 000 24-h accelerometer recordings of activity and sleep as well as 2000 measurements of different cardiometabolic risk factors, including insulin sensitivity, appetite hormones and blood pressure, during nine lunar phases. During the period around full moon, children were 5.0 and 3.2 min per day less active, slept 2.4 and 4.1 min per night longer, had 0.03 and 0.05 higher homeostatic model assessment of insulin resistance and 0.6 and 0.8 mmHg higher mean arterial blood pressure compared with days around half moon and new moon, respectively (all P ≤ 0.02). Furthermore, ghrelin was lower and leptin was higher during the period around full moon compared with days around half moon (both P < 0.001). The results suggest that physical activity rather than sleep is responsible for the metabolic alterations observed around full moon. However, we have no understanding of potential mechanisms that may mediate a potential true link between childhood behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases. PMID:25808903

  3. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle: science behind the myth.

    PubMed

    Sjödin, A; Hjorth, M F; Damsgaard, C T; Ritz, C; Astrup, A; Michaelsen, K F

    2015-04-01

    Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8-11 years, with more than 13,000 24-h accelerometer recordings of activity and sleep as well as 2000 measurements of different cardiometabolic risk factors, including insulin sensitivity, appetite hormones and blood pressure, during nine lunar phases. During the period around full moon, children were 5.0 and 3.2 min per day less active, slept 2.4 and 4.1 min per night longer, had 0.03 and 0.05 higher homeostatic model assessment of insulin resistance and 0.6 and 0.8 mmHg higher mean arterial blood pressure compared with days around half moon and new moon, respectively (all P ≤ 0.02). Furthermore, ghrelin was lower and leptin was higher during the period around full moon compared with days around half moon (both P < 0.001). The results suggest that physical activity rather than sleep is responsible for the metabolic alterations observed around full moon. However, we have no understanding of potential mechanisms that may mediate a potential true link between childhood behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases. PMID:25808903

  4. Neurofibromatosis 1 prevalence in children aged 9-11 years, Pinar del Río Province, Cuba.

    PubMed

    Orraca, Miladys; Morejón, Griselda; Cabrera, Niurka; Menéndez, Reinaldo; Orraca, Odalys

    2014-01-01

    INTRODUCTION Neurofibromatosis 1 is one of the most common heritable genetic disorders in humans. It is characterized by formation of neurofibromas, with marked variability in expression. Half the cases are due to autosomal dominant inheritance; the rest arise from de novo mutations. Prevalence varies by population, and prevalence in Cuba is unknown. OBJECTIVE Determine the prevalence of neurofibromatosis 1 in a population of Cuban children aged 9-11 years old in Pinar del Río Province, Cuba. METHODS A descriptive cross-sectional study was carried out in Pinar del Río Province in 2004, in which 19,392 children were assessed for neurofibromatosis 1. The study was conducted in two phases: the first, a survey of the entire population aged 9-11 years by genetic counselors in the province's schools; the second, assessment by clinical geneticists of children who met criteria for referral to the Provincial Medical Genetics Center. Neurofibromatosis 1 cases and first-degree relatives were examined to identify the origin of the mutation (de novo or inherited). Neurofibromatosis 1 prevalence was calculated, as well as history of a first-degree relative with the disease and frequency of several principal clinical signs-café au lait spots, freckles in places unexposed to sunlight, presence of neurofibromas, Lisch nodules and characteristic bone lesions. RESULTS Of the eligible population, 99.3% was screened (10,034 boys and 9358 girls). Active case finding resulted in referral of 200 children to medical geneticists and the disease was confirmed in 17, for a prevalence of one case per 1141 children aged 9-11 years old. Café au lait spots were the most frequent sign (100%), followed by freckles in areas unexposed to sunlight (82.4%) and characteristic bone lesions (41.2%). Only 4 of the 17 cases were previously being treated for the disease. CONCLUSIONS Neurofibromatosis 1 has high prevalence in the group studied in Pinar del Rio Province and most cases are not detected in

  5. A case of dissociative fugue and general amnesia with an 11-year follow-up.

    PubMed

    Helmes, Edward; Brown, Julie-May; Elliott, Linda

    2015-01-01

    Dissociative fugue refers to loss of personal identity, often with the associated loss of memories of events (general amnesia). Here we report on the psychological assessment of a 54-year-old woman with loss of identity and memories of 33 years of her life attributed to dissociative fugue, along with a follow-up 11 years later. Significant levels of personal injury and stress preceded the onset of the amnesia. A detailed neuropsychological assessment was completed at a university psychology clinic, with a follow-up assessment there about 11 years later with an intent to determine whether changes in her cognitive status were associated with better recall of her life and with her emotional state. Psychomotor slowing and low scores on measures of attention and both verbal and visual memory were present initially, along with significant psychological distress associated with the diagnosis of posttraumatic stress disorder. Although memories of her life had not returned by follow-up, distress had abated and memory test scores had improved. The passage of time and a better emotional state did not lead to recovery of lost memories. Contrary to expectations, performance on tests of executive functions was good on both occasions. Multiple stressful events are attributed as having a role in maintaining the loss of memories. PMID:25365262

  6. Frequency of family meals and 6-11-year-old children's social behaviors.

    PubMed

    Lora, Karina R; Sisson, Susan B; DeGrace, Beth W; Morris, Amanda S

    2014-08-01

    Family meals are regarded as an opportunity to promote healthy child development. In this brief report, we examined the relationship between frequency of family meals and children's social behaviors in 6-11-year-olds. The 2007 U.S. National Survey of Children's Health (NSCH) provided data on the frequency of family meals in a sample of 6-11-year-old children (N = 24,167). The following social behavior indicators were examined: child positive social skills, child problematic social behaviors, child engagement in school, and parental aggravation with the child. Individual logistic regression analyses were calculated in unadjusted and adjusted models. On average, families had 5.3 meals together per week. In adjusted models, more frequent family meals increased the odds of child positive social skills (OR = 1.08, 95% CI [1.02, 1.16]) and child engagement in school (OR = 1.11, 95% CI [1.06, 1.15]), and decreased the likelihood of child problematic social behaviors (OR = 0.92, 95% CI [0.87, 0.98]). There was no association between frequency of family meals and parental aggravation with the child (OR = 0.98, 95% CI [0.93, 1.04]). Findings support the promotion of family meals to benefit children's development of healthy social behaviors.

  7. A case of dissociative fugue and general amnesia with an 11-year follow-up.

    PubMed

    Helmes, Edward; Brown, Julie-May; Elliott, Linda

    2015-01-01

    Dissociative fugue refers to loss of personal identity, often with the associated loss of memories of events (general amnesia). Here we report on the psychological assessment of a 54-year-old woman with loss of identity and memories of 33 years of her life attributed to dissociative fugue, along with a follow-up 11 years later. Significant levels of personal injury and stress preceded the onset of the amnesia. A detailed neuropsychological assessment was completed at a university psychology clinic, with a follow-up assessment there about 11 years later with an intent to determine whether changes in her cognitive status were associated with better recall of her life and with her emotional state. Psychomotor slowing and low scores on measures of attention and both verbal and visual memory were present initially, along with significant psychological distress associated with the diagnosis of posttraumatic stress disorder. Although memories of her life had not returned by follow-up, distress had abated and memory test scores had improved. The passage of time and a better emotional state did not lead to recovery of lost memories. Contrary to expectations, performance on tests of executive functions was good on both occasions. Multiple stressful events are attributed as having a role in maintaining the loss of memories.

  8. Er:YAG laser ablation: 5-11 years prospective study

    NASA Astrophysics Data System (ADS)

    Dostalova, Tatjana; Jelinkova, Helena; Nemec, Michal; Sulc, Jan; Miyagi, Mitsunobu

    2005-03-01

    The Er:YAG laser at 2940 nm has been proposed for use in dental cavity preparation and removal of carious enamel and dentin. The purpose of the present study was to determine the effect of the Er:YAG laser ablation in treating dental caries after a period from 5 to 11 years. For this study, 133 cavities were chosen, and for their reparation of it the three restorative materials were used. Baseline examination was made in the following intervals: one week, 1 year, and from 5 to 11 years after cavity preparation and placement of filling material. Clinical assessments were carried out in accordance with the US Public Health Service System. The follow-up included: the marginal ridge, marginal adaptation, anatomic form, caries, color match, cavo surface margin discoloration, surface smoothness, and postoperative sensitivity. Er:YAG laser ablation is an excellent method for treating frontal teeth, i.e., incisors, canines, premolars, and initial occlusal caries of molars. However, visual control of non-contact therapy is necessary. Er:YAG laser ablation is safe, and it strongly reduces pain. The laser treatment markedly decreases the unpleasant sound and vibration.

  9. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.

    PubMed

    Ng, Oi-Wing; Chia, Adeline; Tan, Anthony T; Jadi, Ramesh S; Leong, Hoe Nam; Bertoletti, Antonio; Tan, Yee-Joo

    2016-04-12

    Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable. PMID:26954467

  10. Fuel cycle centers revisited: Consolidation of fuel cycle activities in a few countries

    SciTech Connect

    Kratzer, M.B.

    1996-07-01

    Despite varied expressions, the general impression remains that the international fuel cycle center concept, whatever its merits, is visionary. It also is quite possibly unattainable in light of strong national pressures toward independence and self-sufficiency in all things nuclear. Is the fuel cycle center an idea that has come and gone? Is it an idea whose time has not yet come? Or is it, as this paper suggests, an idea that has already arrived on the scene, attracting little attention or even acknowledgement of its presence? The difficult in answering this questions arises, in part, from the fact that despite its long and obvious appeal, there has been very little systematic analysis of the concept itself. Such obvious questions as how many and where fuel cycle centers should be located; what characteristics should the hot country or countries possess; and what are the institutional forms or features that endow the concept with enhanced proliferation protection have rarely been seriously and systematically addressed. The title of this paper focuses on limiting the geographic spread of fuel cycle facilities, and some may suggest that doing so does not necessarily call for any type of international or multinational arrangements applicable to those that exist. It is a premise of this paper, however, that a restriction on the number of countries possessing sensitive fuel cycle facilities necessarily involves some degree of multinationalization. This is not only because in every instance a nonproliferation pledge and international or multinational safeguards, or both, will be applied to the facility, but also because a restriction on the number of countries possessing these facilities implies that those in existence will serve a multinational market. This feature in itself is an important form of international auspices. Thus, the two concepts--limitation and multinationalization--if not necessarily one and the same, are at least de facto corollaries.

  11. Extracellular enzyme activity and biogeochemical cycling in restored prairies

    NASA Astrophysics Data System (ADS)

    Lynch, L.; Hernandez, D.; Schade, J. D.

    2011-12-01

    Winter microbial activity in mid-latitude prairie ecosystems is thermally sensitive and significantly influenced by snow depth. Snow insulates the soil column facilitating microbial processing of complex organic substrates. Previous studies in forests and tundra ecosystems suggest patterns of substrate utilization and limitation are seasonal; above freezing, soil microbes access fresh litter inputs and sugar exudates from plant roots, while under frozen condition they recycle nutrients incorporated in microbial biomass. In order to liberate nutrients required for carbon degradation, soil microbes invest energy in the production of extracellular enzymes that cleave monomers from polymer bonds. The inverse relationship between relative enzyme abundance and substrate availability makes enzyme assays a useful proxy to assess changes in resources over time. Our objective in this study was to assess patterns in microbial biomass, nutrient availability, and extracellular enzyme activity in four snow exclosure sites over a seven-month period. Over the past three years, we have maintained a snow removal experiment on two restored prairies in central Minnesota. In each prairie, snow was continuously removed annually from two 4 x 4 m plots by shoveling after each snow event. Extractable C, N and P, and microbial C, N and P in soil samples were measured in samples collected from these snow removal plots, as well as in adjacent unmanipulated prairie control plots. Pools of C, N, and P were estimated using standard extraction protocols, and microbial pools were estimated using chloroform fumigation direct extraction (CFDE). We conducted fluorometric extracellular enzyme assays (EEA) to assess how the degradation potential of cellulose (cellobiohydrolase, CBH), protein (leucine aminopeptidase, LAP), and phosphate esters (phosphatase, PHOS) changed seasonally. Microbial C and N declined between October and June, while microbial P declined during the fall and winter, but increased

  12. Element Pool Changes within a Scrub-Oak Ecosystem after 11 Years of Exposure to Elevated CO2

    PubMed Central

    Duval, Benjamin D.; Dijkstra, Paul; Drake, Bert G.; Johnson, Dale W.; Ketterer, Michael E.; Megonigal, J. Patrick; Hungate, Bruce A.

    2013-01-01

    The effects of elevated CO2 on ecosystem element stocks are equivocal, in part because cumulative effects of CO2 on element pools are difficult to detect. We conducted a complete above and belowground inventory of non-nitrogen macro- and micronutrient stocks in a subtropical woodland exposed to twice-ambient CO2 concentrations for 11 years. We analyzed a suite of nutrient elements and metals important for nutrient cycling in soils to a depth of ∼2 m, in leaves and stems of the dominant oaks, in fine and coarse roots, and in litter. In conjunction with large biomass stimulation, elevated CO2 increased oak stem stocks of Na, Mg, P, K, V, Zn and Mo, and the aboveground pool of K and S. Elevated CO2 increased root pools of most elements, except Zn. CO2-stimulation of plant Ca was larger than the decline in the extractable Ca pool in soils, whereas for other elements, increased plant uptake matched the decline in the extractable pool in soil. We conclude that elevated CO2 caused a net transfer of a subset of nutrients from soil to plants, suggesting that ecosystems with a positive plant growth response under high CO2 will likely cause mobilization of elements from soil pools to plant biomass. PMID:23717607

  13. Life cycle assessment of active and passive groundwater remediation technologies

    NASA Astrophysics Data System (ADS)

    Bayer, Peter; Finkel, Michael

    2006-02-01

    Groundwater remediation technologies, such as pump-and-treat (PTS) and funnel-and-gate systems (FGS), aim at reducing locally appearing contaminations. Therefore, these methodologies are basically evaluated with respect to their capability to yield local improvements of an environmental situation, commonly neglecting that their application is also associated with secondary impacts. Life cycle assessment (LCA) represents a widely accepted method of assessing the environmental aspects and potential impacts related to a product, process or service. This study presents the set-up of a LCA framework in order to compare the secondary impacts caused by two conceptually different technologies at the site of a former manufactured gas plant in the city of Karlsruhe, Germany. As a FGS is already operating at this site, a hypothetical PTS of the same functionality is adopted. During the LCA, the remediation systems are evaluated by focusing on the main technical elements and their significance with respect to resource depletion and potential adverse effects on ecological quality, as well as on human health. Seven impact categories are distinguished to address a broad spectrum of possible environmental loads. A main point of discussion is the reliability of technical assumptions and performance predictions for the future. It is obvious that a high uncertainty exists when estimating impact specific indicator values over operation times of decades. An uncertainty analysis is conducted to include the imprecision of the underlying emission and consumption data and a scenario analysis is utilised to contrast various possible technological variants. Though the results of the study are highly site-specific, a generalised relative evaluation of potential impacts and their main sources is the principle objective rather than a discussion of the calculated absolute impacts. A crucial finding that can be applied to any other site is the central role of steel, which particularly derogates

  14. Life cycle assessment of active and passive groundwater remediation technologies.

    PubMed

    Bayer, Peter; Finkel, Michael

    2006-02-10

    Groundwater remediation technologies, such as pump-and-treat (PTS) and funnel-and-gate systems (FGS), aim at reducing locally appearing contaminations. Therefore, these methodologies are basically evaluated with respect to their capability to yield local improvements of an environmental situation, commonly neglecting that their application is also associated with secondary impacts. Life cycle assessment (LCA) represents a widely accepted method of assessing the environmental aspects and potential impacts related to a product, process or service. This study presents the set-up of a LCA framework in order to compare the secondary impacts caused by two conceptually different technologies at the site of a former manufactured gas plant in the city of Karlsruhe, Germany. As a FGS is already operating at this site, a hypothetical PTS of the same functionality is adopted. During the LCA, the remediation systems are evaluated by focusing on the main technical elements and their significance with respect to resource depletion and potential adverse effects on ecological quality, as well as on human health. Seven impact categories are distinguished to address a broad spectrum of possible environmental loads. A main point of discussion is the reliability of technical assumptions and performance predictions for the future. It is obvious that a high uncertainty exists when estimating impact specific indicator values over operation times of decades. An uncertainty analysis is conducted to include the imprecision of the underlying emission and consumption data and a scenario analysis is utilised to contrast various possible technological variants. Though the results of the study are highly site-specific, a generalised relative evaluation of potential impacts and their main sources is the principle objective rather than a discussion of the calculated absolute impacts. A crucial finding that can be applied to any other site is the central role of steel, which particularly derogates

  15. Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity

    PubMed Central

    Hodille, Elisabeth; Alekseeva, Ludmila; Berkova, Nadia; Serrier, Asma; Badiou, Cedric; Gilquin, Benoit; Brun, Virginie; Vandenesch, François; Terman, David S.; Lina, Gerard

    2016-01-01

    Maintenance of an intact epithelial barrier constitutes a pivotal defense mechanism against infections. Staphylococcus aureus is a versatile pathogen that produces multiple factors including exotoxins that promote tissue alterations. The aim of the present study is to investigate the cytopathic effect of staphylococcal exotoxins SEA, SEG, SEI, SElM, SElN and SElO on the cell cycle of various human cell lines. Among all tested exotoxins only SEIO inhibited the proliferation of a broad panel of human tumor cell lines in vitro. Evaluation of a LDH release and a DNA fragmentation of host cells exposed to SEIO revealed that the toxin does not induce necrosis or apoptosis. Analysis of the DNA content of tumor cells synchronized by serum starvation after exposure to SEIO showed G0/G1 cell cycle delay. The cell cycle modulating feature of SEIO was confirmed by the flow cytometry analysis of synchronized cells exposed to supernatants of isogenic S. aureus strains wherein only supernatant of the SElO producing strain induced G0/G1 phase delay. The results of yeast-two-hybrid analysis indicated that SEIO’s potential partner is cullin-3, involved in the transition from G1 to S phase. In conclusion, we provide evidence that SEIO inhibits cell proliferation without inducing cell death, by delaying host cell entry into the G0/G1 phase of the cell cycle. We speculate that this unique cell cycle modulating feature allows SEIO producing bacteria to gain advantage by arresting the cell cycle of target cells as part of a broader invasive strategy. PMID:27148168

  16. Pulmonary veno-occlusive disease in an 11-year-old girl: diagnostic pitfalls.

    PubMed

    Kano, Gen; Nakamura, Keiko; Sakamoto, Izumi

    2014-02-01

    Pulmonary veno-occlusive disease (PVOD) is a rare chronic lung disease that is difficult to diagnose due to non-specific clinical findings. Little is known about the pathogenesis of PVOD. Reported herein is the case of an 11-year-old girl who initially presented with 'bat-wing' shadows on chest radiography. This finding, coupled with prominent hemosiderosis in bronchoalveolar lavage fluid, initially led to a misdiagnosis of idiopathic pulmonary hemosiderosis. Oral prednisolone dramatically improved signs and symptoms initially, but her condition then gradually deteriorated during maintenance therapy with corticosteroids and other immunosuppressants. PVOD was suspected but not confirmed owing to a lack of hallmark radiographic findings and contraindications for lung biopsy. Three years later, while arranging for lung transplantation, the patient experienced sudden onset of fatal massive pulmonary edema. PVOD was confirmed at autopsy. This case provides insights regarding an unfamiliar presentation of PVOD and may help physicians to avoid diagnostic pitfalls.

  17. An 11-year-old boy with pharyngitis and cough: Lemierre syndrome

    PubMed Central

    Mação, Patricia; Cancelinha, Candida; Lopes, Paulo; Rodrigues, Fernanda

    2013-01-01

    The authors present the case of an 11-year-old boy with pharyngitis, treated with amoxicillin, that worsened on day 7, with cough, high fever and refusal to eat. Lethargy and respiratory distress were noted. Based on radiographic findings of bilateral infiltrates he was diagnosed with pneumonia and started on intravenous ampicillin and erythromycin. Two days later he complained of right-sided neck pain and a palpable mass was identified. An ultrasound showed partial thrombosis of the right internal jugular vein and a lung CT scan revealed multiple septic embolic lesions. Lemierre syndrome was diagnosed, antibiotic treatment adjusted and anticoagulation started. A neck CT-scan showed a large parapharyngeal abscess. His clinical condition improved gradually and after 3 weeks of intravenous antibiotics he was discharged home on oral treatment. This case illustrates the importance of diagnosing Lemierre syndrome in the presence of pharyngitis with localised neck pain and respiratory distress, to prevent potentially fatal complications. PMID:23616317

  18. A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl.

    PubMed

    Severinski, Srećko; Butorac Ahel, Ivona; Ovuka, Aleksandar; Verbić, Arijan

    2016-08-01

    Diabetic ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycemia, metabolic acidosis and ketonuria. Cerebral edema is the most common rare complication of DKA in children. The objective of the study was to emphasize the importance of careful evaluation and monitoring for signs and symptoms of cerebral edema in all children undergoing treatment for DKA. We present a case of 11-year-old girl with a history of diabetes mellitus type I (T1DM) who presented with severe DKA complicated by hypovolemic shock, cerebral edema and hematemesis. Considering the fact that complications of DKA are rare and require a high index of clinical suspicion, early recognition and treatment are crucial for avoiding permanent damage.

  19. Absorbed doses and radiation damage during the 11 years of LEP operation

    NASA Astrophysics Data System (ADS)

    Schönbacher, H.; Tavlet, M.

    2004-03-01

    During the 11 years of operation of the large electron-positron collider (LEP), synchrotron radiation was emitted in the tunnel. This ionizing radiation induced degradation in organic insulators and structural materials, as well as in electronics. Annual dosimetric measurements have shown that the level of radiation increased with the ninth power of the beam energy. During the machine shutdowns and at the end of the operation, samples of rigid and flexible polymeric insulators (magnet-coil resins and cable insulations) were taken out and checked for their integrity. The test results are compared with the results obtained during the qualification of the materials, 12-15 years ago. At that time, lifetime predictions were made; they are now compared with the real time-aged materials.

  20. The Pioneer Venus Orbiter: 11 years of data. A laboratory for atmospheres seminar talk

    NASA Technical Reports Server (NTRS)

    Kasprzak, W. T.

    1990-01-01

    The Pioneer Venus Orbiter has been in operation since orbit insertion on December 4, 1978. For the past 11 years, it has been acquiring data in the salient features of the planet, its atmosphere, ionosphere, and interaction with the solar wind. A few of the results of this mission are summarized and their contribution to our general understanding of the planet Venus is discussed. Although Earth and Venus are often called twin planets, they are only superficially similar. Possessing no obvious evidence of plate tectonics, lacking water and an intrinsic magnetic field, and having a hot, dense carbon dioxide atmosphere with sulfuric acid clouds makes Venus a unique object of study by the Orbiter's instruments.

  1. A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl.

    PubMed

    Severinski, Srećko; Butorac Ahel, Ivona; Ovuka, Aleksandar; Verbić, Arijan

    2016-08-01

    Diabetic ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycemia, metabolic acidosis and ketonuria. Cerebral edema is the most common rare complication of DKA in children. The objective of the study was to emphasize the importance of careful evaluation and monitoring for signs and symptoms of cerebral edema in all children undergoing treatment for DKA. We present a case of 11-year-old girl with a history of diabetes mellitus type I (T1DM) who presented with severe DKA complicated by hypovolemic shock, cerebral edema and hematemesis. Considering the fact that complications of DKA are rare and require a high index of clinical suspicion, early recognition and treatment are crucial for avoiding permanent damage. PMID:27226096

  2. Performance as a function of shooting style in basketball players under 11 years of age.

    PubMed

    Arias, José L

    2012-04-01

    Shooting style in basketball refers to the height adopted by a player in holding the ball, specifically the height of the hand and the ball with regard to the line of sight before the final extension of the elbow during a shot. The literature differentiates between a high and a low style. This study analyzed shooting frequency in young boys as a function of style and which shooting style had the highest accuracy and success in real games. Participants were 81 boys from eight basketball teams, aged 9-11 years. The sample consisted of 5,740 standard shots in 56 games. The design was nomotethic, follow-up, and multidimensional. The results indicated that low style predominated over the high style, although overall accuracy and efficacy were better using the high style. Various strategies and practical considerations are suggested for teachers and coaches to focus on teaching the high style.

  3. Does school environment affect 11-year-olds' fruit and vegetable intake in Denmark?

    PubMed

    Krølner, Rikke; Due, Pernille; Rasmussen, Mette; Damsgaard, Mogens Trab; Holstein, Bjørn E; Klepp, Knut-Inge; Lynch, John

    2009-04-01

    It is often found that adolescents eat too little fruit and vegetables. We examined the importance of school for 11-year-olds' daily intake measured by food frequency- and 24-h recall questionnaires in Danish data from the European 2003 Pro Children Survey. Multilevel logistic regression analyses included matched student-parent-school questionnaire data (N=1410) from a random sample of 59 schools and were conducted for fruit and vegetables separately: 1) without explanatory variables, to decompose the between-school and within-school variance; 2) with individual level covariates (socioeconomic position, parental intake, etc.) to examine if the between-school variance was attributable to different student compositions of schools; and 3) with individual- and school-level covariates (school availability of fruit/vegetables and unhealthy food) to examine the effect of context. Additional analyses stratified by gender and home availability of fruit/vegetables examined if school food availability influenced subgroups differently. Between-school variations were quantified by intra class correlations and median odds ratios. We found that 40% of the students ate > or = 200 g fruit/day and 25% ate > or = 130 g vegetables/day. Most of the total variance in students' intake occurred at the individual level (93-98%). There were larger between-school variations in vegetable intake than in fruit intake. Fruit and vegetable consumption clustered within schools to a larger degree for boys than girls. The between-school variance did not differ by home availability. Boys and students from high availability homes consumed more fruit and/or vegetables if enrolled in schools with access to fruit/vegetables and unhealthy food or contrarily with no food available versus schools with only fruit/vegetables available. The small school-level effects on 11-year-olds' fruit and vegetable intake imply that family level interventions may be more important and that the success of school

  4. Size at birth and blood pressure: cross sectional study in 8-11 year old children.

    PubMed Central

    Taylor, S. J.; Whincup, P. H.; Cook, D. G.; Papacosta, O.; Walker, M.

    1997-01-01

    OBJECTIVE: To identify which patterns of fetal growth, represented by different measurements of size at birth, are associated with increased blood pressure in children aged 8-11 years. DESIGN AND SETTING: School based, cross sectional survey conducted in 10 towns in England and Wales in 1994. SUBJECTS: 3010 singleton children (response rate 75%) with physical measurements and information on birth weight from parental questionnaires. Hospital birth records were examined for 1573. MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure at age 8-11 years. RESULTS: In the whole group birth weight was inversely related to systolic pressure (regression coefficient -1.48 mm Hg/kg; 95% confidence interval -2.20 to -0.76) after adjustment for current body size. There was no significant association between birth weight and diastolic pressure. The association with systolic pressure was much stronger in girls (-2.54 mm Hg/kg; -3.60 to -1.48) than in boys (-0.64 mm Hg/kg; -1.58 to 0.30), with a significant difference between the sexes (P = 0.006). Among the other neonatal measures, head circumference and placental weight were inversely associated with subsequent blood pressure in girls, and placental ratio (placental weight:birth weight) was positively associated with blood pressure in boys. Neither ponderal index at birth nor length:head circumference ratio was related to blood pressure in either sex. CONCLUSIONS: In these contemporary children the association between birth weight and blood pressure was apparent only in girls. There was no evidence that measures of size at birth, which may be related to nutrition at critical periods of pregnancy (thinness at birth or shortness in relation to head circumference), are related to blood pressure in the offspring. PMID:9056797

  5. Auditory-Motor Learning during Speech Production in 9-11-Year-Old Children

    PubMed Central

    Shiller, Douglas M.; Gracco, Vincent L.; Rvachew, Susan

    2010-01-01

    Background Hearing ability is essential for normal speech development, however the precise mechanisms linking auditory input and the improvement of speaking ability remain poorly understood. Auditory feedback during speech production is believed to play a critical role by providing the nervous system with information about speech outcomes that is used to learn and subsequently fine-tune speech motor output. Surprisingly, few studies have directly investigated such auditory-motor learning in the speech production of typically developing children. Methodology/Principal Findings In the present study, we manipulated auditory feedback during speech production in a group of 9–11-year old children, as well as in adults. Following a period of speech practice under conditions of altered auditory feedback, compensatory changes in speech production and perception were examined. Consistent with prior studies, the adults exhibited compensatory changes in both their speech motor output and their perceptual representations of speech sound categories. The children exhibited compensatory changes in the motor domain, with a change in speech output that was similar in magnitude to that of the adults, however the children showed no reliable compensatory effect on their perceptual representations. Conclusions The results indicate that 9–11-year-old children, whose speech motor and perceptual abilities are still not fully developed, are nonetheless capable of auditory-feedback-based sensorimotor adaptation, supporting a role for such learning processes in speech motor development. Auditory feedback may play a more limited role, however, in the fine-tuning of children's perceptual representations of speech sound categories. PMID:20886033

  6. Teaching Ecosystems and Matter Cycles with Creative Drama Activities

    ERIC Educational Resources Information Center

    Cokadar, Hulusi; Yilmaz, Gulcin Cihan

    2010-01-01

    The purpose of this study is to examine the effect of creative drama-based instruction on seventh graders' science achievements in the ecology and matter cycles unit and their attitudes toward science. The study is an experimental study carried out in one of the public elementary schools in Turkey during 2005-2006 schooling year. An ecological…

  7. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.

    PubMed

    Zímová, Jana; Zímová, Pavlína

    2016-06-01

    Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a patient`s repetitive self-pulling of hair. The disorder is included under anxiety disorders because it shares some obsessive-compulsive features. Patients have the tendency towards feelings of unattractiveness, body dissatisfaction, and low self-esteem (1,2). It is a major psychiatric problem, but many patients with this disorder first present to a dermatologist. An 11-year-old girl came to our department with a 2-month history of diffuse hair loss on the frontoparietal and parietotemporal area (Figure 1). She had originally been examined by a pediatrician with the diagnosis of alopecia areata. The patient`s personal history included hay fever and shortsightedness, and she suffered from varicella and mononucleosis. Nobody in the family history suffered from alopecia areata, but her father has male androgenetic alopecia (Norwood/Hamilton MAGA C3F3). The mother noticed that the child had had changeable mood for about 2 months and did not want to communicate with other persons in the family. The family did not have any pet at home. At school, her favorite subjects were Math and Computer Studies. She did not like Physical Education and did not participate in any sport activities during her free time. This was very strange because she was obese (body-mass index (BMI) 24.69). She was sometimes angry with her 13-year-old sister who had better results at school. The girl had suddenly started to wear a blue scarf. The parents did not notice that she pulled out her hair at home. Dermatological examination of the capillitium found a zone of incomplete alopecia in the frontoparietal and parietotemporal area, without inflammation, desquamation, and scaring. Hairs were of variable length (Figure 1). There was a patch of incomplete alopecia above the forehead between two stripes of hair of variable length (Figure 2). The hair pull test was

  8. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.

    PubMed

    Zímová, Jana; Zímová, Pavlína

    2016-06-01

    Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a patient`s repetitive self-pulling of hair. The disorder is included under anxiety disorders because it shares some obsessive-compulsive features. Patients have the tendency towards feelings of unattractiveness, body dissatisfaction, and low self-esteem (1,2). It is a major psychiatric problem, but many patients with this disorder first present to a dermatologist. An 11-year-old girl came to our department with a 2-month history of diffuse hair loss on the frontoparietal and parietotemporal area (Figure 1). She had originally been examined by a pediatrician with the diagnosis of alopecia areata. The patient`s personal history included hay fever and shortsightedness, and she suffered from varicella and mononucleosis. Nobody in the family history suffered from alopecia areata, but her father has male androgenetic alopecia (Norwood/Hamilton MAGA C3F3). The mother noticed that the child had had changeable mood for about 2 months and did not want to communicate with other persons in the family. The family did not have any pet at home. At school, her favorite subjects were Math and Computer Studies. She did not like Physical Education and did not participate in any sport activities during her free time. This was very strange because she was obese (body-mass index (BMI) 24.69). She was sometimes angry with her 13-year-old sister who had better results at school. The girl had suddenly started to wear a blue scarf. The parents did not notice that she pulled out her hair at home. Dermatological examination of the capillitium found a zone of incomplete alopecia in the frontoparietal and parietotemporal area, without inflammation, desquamation, and scaring. Hairs were of variable length (Figure 1). There was a patch of incomplete alopecia above the forehead between two stripes of hair of variable length (Figure 2). The hair pull test was

  9. Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model

    PubMed Central

    Kim, Min Hyeok; Kim, Young Jin; Kim, Hee Ryung; Jeon, Tae-Joon; Choi, Jae Boong; Chung, Ka Young; Kim, Moon Ki

    2016-01-01

    Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a GDP-bound G protein heterotrimer. The G protein cycle is allosterically modulated by conformational changes of the Gα subunit. Although biochemical and biophysical methods have elucidated the structure and dynamics of Gα, the precise conformational mechanisms underlying the G protein cycle are not fully understood yet. Simulation methods could help to provide additional details to gain further insight into G protein signal transduction mechanisms. In this study, using the available X-ray crystal structures of Gα, we simulated the entire G protein cycle and described not only the steric features of the Gα structure, but also conformational changes at each step. Each reference structure in the G protein cycle was modeled as an elastic network model and subjected to normal mode analysis. Our simulation data suggests that activated receptors trigger conformational changes of the Gα subunit that are thermodynamically favorable for opening of the nucleotide-binding pocket and GDP release. Furthermore, the effects of GTP binding and hydrolysis on mobility changes of the C and N termini and switch regions are elucidated. In summary, our simulation results enabled us to provide detailed descriptions of the structural and dynamic features of the G protein cycle. PMID:27483005

  10. [Bioelectric activity of cervix uteri in normal menstrual cycle and in the syndrome of sclerocystic ovaries].

    PubMed

    Rymashevskiĭ, V K; Kozhin, A A; Chzhan Chun'; Gorchakov, L A

    1974-10-01

    34 20-26 year old women with anovulatory cycles with the Stein syndrome and 5 women with normal menstrual cycles were studied in regard to bioelectric cervical activity by means of a vaginal probe and the micrograph ''Medicore.'' In the control group, an increase of progesterone in the 2nd phase of the cycle led to a decrease in the electromyographic (EMG) amplitude. In the anovulatory cycle, the extended activity of estrogens and minimal amount of progesterone stimulated a high tone of uterine impulses, which was substantiated by a high EMG proved to be effective and useful in the diagnosis of gynecological patients. PMID:4440834

  11. Performance improvement: an active life cycle product management

    NASA Astrophysics Data System (ADS)

    Cucchiella, Federica; Gastaldi, Massimo; Lenny Koh, S. C.

    2010-03-01

    The management of the supply chain has gained importance in many manufacturing firms. Operational flexibility can be considered a crucial weapon to increase competitiveness in a turbulent marketplace. It reflects the ability of a firm to properly and rapidly respond to a variable and dynamic environment. For the firm operating in a fashion sector, the management of the supply chain is even more complex because the product life cycle is shorter than that of the firm operating in a non-fashion sector. The increase of firm flexibility level can be reached through the application of the real option theory inside the firm network. In fact, real option may increase the project value by allowing managers to more efficiently direct the production. The real option application usually analysed in literature does not take into account that the demands of products are well-defined by the product life cycle. Working on a fashion sector, the life cycle pattern is even more relevant because of an expected demand that grows according to a constant rate that does not capture the demand dynamics of the underlying fashion goods. Thus, the primary research objective of this article is to develop a model useful for the management of investments in a supply chain operating in a fashion sector where the system complexity is increased by the low level of unpredictability and stability that is proper of the mood phenomenon. Moreover, unlike the traditional model, a real option framework is presented here that considers fashion product characterised by uncertain stages of the production cycle.

  12. Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription

    PubMed Central

    Banyai, Gabor; Baïdi, Feriel; Coudreuse, Damien; Szilagyi, Zsolt

    2016-01-01

    Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and requires the periodic expression of particular gene clusters in different cell cycle phases. However, the interplay between the networks that generate these transcriptional oscillations and the core cell cycle machinery remains largely unexplored. In this work, we use a synthetic regulable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity, with different clusters directly responding to specific activity levels. We further establish that cell cycle events neither participate in nor interfere with the Cdk1-driven transcriptional program, provided that cells are exposed to the appropriate Cdk1 activities. These findings contrast with current models that propose self-sustained and Cdk1-independent transcriptional oscillations. Our work therefore supports a model in which Cdk1 activity serves as a quantitative platform for coordinating cell cycle transitions with the expression of critical genes to bring about proper cell cycle progression. PMID:27045731

  13. Prediction of Solar Activity from Solar Background Magnetic Field Variations in Cycles 21-23

    NASA Astrophysics Data System (ADS)

    Shepherd, Simon J.; Zharkov, Sergei I.; Zharkova, Valentina V.

    2014-11-01

    A comprehensive spectral analysis of both the solar background magnetic field (SBMF) in cycles 21-23 and the sunspot magnetic field in cycle 23 reported in our recent paper showed the presence of two principal components (PCs) of SBMF having opposite polarity, e.g., originating in the northern and southern hemispheres, respectively. Over a duration of one solar cycle, both waves are found to travel with an increasing phase shift toward the northern hemisphere in odd cycles 21 and 23 and to the southern hemisphere in even cycle 22. These waves were linked to solar dynamo waves assumed to form in different layers of the solar interior. In this paper, for the first time, the PCs of SBMF in cycles 21-23 are analyzed with the symbolic regression technique using Hamiltonian principles, allowing us to uncover the underlying mathematical laws governing these complex waves in the SBMF presented by PCs and to extrapolate these PCs to cycles 24-26. The PCs predicted for cycle 24 very closely fit (with an accuracy better than 98%) the PCs derived from the SBMF observations in this cycle. This approach also predicts a strong reduction of the SBMF in cycles 25 and 26 and, thus, a reduction of the resulting solar activity. This decrease is accompanied by an increasing phase shift between the two predicted PCs (magnetic waves) in cycle 25 leading to their full separation into the opposite hemispheres in cycle 26. The variations of the modulus summary of the two PCs in SBMF reveals a remarkable resemblance to the average number of sunspots in cycles 21-24 and to predictions of reduced sunspot numbers compared to cycle 24: 80% in cycle 25 and 40% in cycle 26.

  14. Prediction of solar activity from solar background magnetic field variations in cycles 21-23

    SciTech Connect

    Shepherd, Simon J.; Zharkov, Sergei I.; Zharkova, Valentina V. E-mail: s.zharkov@hull.ac.uk

    2014-11-01

    A comprehensive spectral analysis of both the solar background magnetic field (SBMF) in cycles 21-23 and the sunspot magnetic field in cycle 23 reported in our recent paper showed the presence of two principal components (PCs) of SBMF having opposite polarity, e.g., originating in the northern and southern hemispheres, respectively. Over a duration of one solar cycle, both waves are found to travel with an increasing phase shift toward the northern hemisphere in odd cycles 21 and 23 and to the southern hemisphere in even cycle 22. These waves were linked to solar dynamo waves assumed to form in different layers of the solar interior. In this paper, for the first time, the PCs of SBMF in cycles 21-23 are analyzed with the symbolic regression technique using Hamiltonian principles, allowing us to uncover the underlying mathematical laws governing these complex waves in the SBMF presented by PCs and to extrapolate these PCs to cycles 24-26. The PCs predicted for cycle 24 very closely fit (with an accuracy better than 98%) the PCs derived from the SBMF observations in this cycle. This approach also predicts a strong reduction of the SBMF in cycles 25 and 26 and, thus, a reduction of the resulting solar activity. This decrease is accompanied by an increasing phase shift between the two predicted PCs (magnetic waves) in cycle 25 leading to their full separation into the opposite hemispheres in cycle 26. The variations of the modulus summary of the two PCs in SBMF reveals a remarkable resemblance to the average number of sunspots in cycles 21-24 and to predictions of reduced sunspot numbers compared to cycle 24: 80% in cycle 25 and 40% in cycle 26.

  15. Altered lower leg muscle activation patterns in patients with cerebral palsy during cycling on an ergometer

    PubMed Central

    Alves-Pinto, Ana; Blumenstein, Tobias; Turova, Varvara; Lampe, Renée

    2016-01-01

    Objective Cycling on a recumbent ergometer constitutes one of the most popular rehabilitation exercises in cerebral palsy (CP). However, no control is performed on how muscles are being used during training. Given that patients with CP present altered muscular activity patterns during cycling or walking, it is possible that an incorrect pattern of muscle activation is being promoted during rehabilitation cycling. This study investigated patterns of muscular activation during cycling on a recumbent ergometer in patients with CP and whether those patterns are determined by the degree of spasticity and of mobility. Methods Electromyographic (EMG) recordings of lower leg muscle activation during cycling on a recumbent ergometer were performed in 14 adult patients diagnosed with CP and five adult healthy participants. EMG recordings were done with an eight-channel EMG system built in the laboratory. The activity of the following muscles was recorded: Musculus rectus femoris, Musculus biceps femoris, Musculus tibialis anterior, and Musculus gastrocnemius. The degree of muscle spasticity and mobility was assessed using the Modified Ashworth Scale and the Gross Motor Function Classification System, respectively. Muscle activation patterns were described in terms of onset and duration of activation as well as duration of cocontractions. Results Muscle activation in CP was characterized by earlier onsets, longer periods of activation, a higher occurrence of agonist–antagonist cocontractions, and a more variable cycling tempo in comparison to healthy participants. The degree of altered muscle activation pattern correlated significantly with the degree of spasticity. Conclusion This study confirmed the occurrence of altered lower leg muscle activation patterns in patients with CP during cycling on a recumbent ergometer. There is a need to develop feedback systems that can inform patients and therapists of an incorrect muscle activation during cycling and support the training

  16. The 11-year long-term follow-up study from the randomized BENEFIT CIS trial

    PubMed Central

    Edan, Gilles; Freedman, Mark S.; Montalbán, Xavier; Hartung, Hans-Peter; Hemmer, Bernhard; Fox, Edward J.; Barkhof, Frederik; Schippling, Sven; Schulze, Andrea; Pleimes, Dirk; Pohl, Christoph; Sandbrink, Rupert; Suarez, Gustavo; Wicklein, Eva-Maria

    2016-01-01

    Objective: To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or after a short delay. Methods: Participants in BENEFIT (Betaferon/Betaseron in Newly Emerging MS for Initial Treatment) were randomly assigned to receive interferon beta-1b (early treatment) or placebo (delayed treatment). After conversion to clinically definite multiple sclerosis (CDMS) or 2 years, patients on placebo could switch to interferon beta-1b or another treatment. Eleven years after randomization, patients were reassessed. Results: Two hundred seventy-eight (59.4%) of the original 468 patients (71.3% of those eligible at participating sites) were enrolled (early: 167 [57.2%]; delayed: 111 [63.1%]). After 11 years, risk of CDMS remained lower in the early-treatment arm compared with the delayed-treatment arm (p = 0.0012), with longer time to first relapse (median [Q1, Q3] days: 1,888 [540, not reached] vs 931 [253, 3,296]; p = 0.0005) and lower overall annualized relapse rate (0.21 vs 0.26; p = 0.0018). Only 25 patients (5.9%, overall; early, 4.5%; delayed, 8.3%) converted to secondary progressive multiple sclerosis. Expanded Disability Status Scale scores remained low and stable, with no difference between treatment arms (median [Q1, Q3]: 2.0 [1.0, 3.0]). The early-treatment group had better Paced Auditory Serial Addition Task–3 total scores (p = 0.0070). Employment rates remained high, and health resource utilization tended to be low in both groups. MRI metrics did not differ between groups. Conclusions: Although the delay in treatment was relatively short, several clinical outcomes favored earlier treatment. Along with low rates of disability and disease progression in both groups, this supports the value of treatment at CIS. ClinicalTrials.gov identifier: NCT01795872. Classification of evidence: This study provides Class IV evidence that early compared to delayed treatment prolongs time to CDMS in CIS after 11 years. PMID

  17. Reporting accuracy of packed lunch consumption among Danish 11-year-olds differ by gender

    PubMed Central

    Lyng, Nina; Fagt, Sisse; Davidsen, Michael; Hoppe, Camilla; Holstein, Bjørn; Tetens, Inge

    2013-01-01

    Background Packed lunch is the dominant lunch format in many countries including Denmark. School lunch is consumed unsupervised, and self-reported recalls are appropriate in the school setting. However, little is known about the accuracy of recalls in relation to packed lunch. Objective To assess the qualitative recall accuracy of self-reported consumption of packed lunch among Danish 11-year-old children in relation to gender and dietary assessment method. Design A cross-sectional dietary recall study of packed lunch consumption. Digital images (DIs) served as an objective reference method to determine food items consumed. Recalls were collected with a lunch recall questionnaire (LRQ) comprising an open-ended recall (OE-Q) and a pre-coded food group prompted recall (PC-Q). Individual interviews (INTs) were conducted successively. The number of food items was identified and accuracy was calculated as match rates (% identified by DIs and reported correctly) and intrusion rates (% not identified by DIs but reported) were determined. Setting and subjects Three Danish public schools from Copenhagen. A total of 114 Danish 11-year-old children, mean (SE) age=11.1 (0.03), and body mass index=18.2 (0.26). Results The reference (DIs) showed that girls consumed a higher number of food items than boys [mean (SE) 5.4 (0.25) vs. 4.6 (0.29) items (p=0.05)]. The number of food items recalled differed between genders with OE-Q recalls (p=0.005) only. Girls’ interview recalls were more accurate than boys’ with higher match rates (p=0.04) and lower intrusion rates (p=0.05). Match rates ranged from 67–90% and intrusion rates ranged from 13–39% with little differences between girls and boys using the OE-Q and PC-Q methods. Conclusion Dietary recall validation studies should not only consider match rates as an account of accuracy. Intrusions contribute to over-reporting in non-validation studies, and future studies should address recall accuracy and inaccuracies in relation to

  18. Examining Relative Age Effects in Fundamental Skill Proficiency in British Children Aged 6-11 Years.

    PubMed

    Birch, Samantha; Cummings, Laura; Oxford, Samuel W; Duncan, Michael J

    2016-10-01

    Birch, S, Cummings, L, Oxford, SW, and Duncan, MJ. Examining relative age effects in fundamental skill proficiency in British children aged 6-11 years. J Strength Cond Res 30(10): 2809-2815, 2016-The relative age effect (RAE) suggests that there is a clustering of birth dates just after the cutoff used for sports selection in age-grouped sports and that in such circumstances, relatively older sportspeople may enjoy maturational and physical advantages over their younger peers. Few studies have examined this issue in nonselective groups of children, and none have examined whether there is evidence of any RAE in skill performance. The aim of this study was to assess whether there were differences in fundamental movement skill (FMS) proficiency within children placed in age groups according to the school year. Six FMS (sprint, side gallop, balance, jump, catch, and throw) were assessed in 539 school children (258 boys and 281 girls) aged 6-11 years (mean age ± SD = 7.7 ± 1.7 years). We examined differences in these FMS between gender groups and children born in different quarters of the year after controlling for age and body mass index (BMI). For balance, chronological age was significant as a covariate (p = 0.0001) with increases in age associated with increases in balance. Boys had significantly higher sprint mastery compared with girls (p = 0.012), and increased BMI was associated with poorer sprint mastery (p = 0.001). Boys had higher catching mastery than girls (p = 0.003), and children born in Q1 had significantly greater catching mastery than those born in Q2 (p = 0.015), Q3 (p = 0.019), and Q4 (p = 0.01). Results for throwing mastery also indicated higher mastery in boys compared with girls (p = 0.013) and that children born in Q1 had higher throwing proficiency than those born in Q4 (p = 0.038). These results are important if coaches are basing sport selection on measures of skilled performance, particularly in object-control skills. Categorizing children

  19. Respiratory Muscle Activity During Simultaneous Stationary Cycling and Inspiratory Muscle Training.

    PubMed

    Hellyer, Nathan J; Folsom, Ian A; Gaz, Dan V; Kakuk, Alynn C; Mack, Jessica L; Ver Mulm, Jacyln A

    2015-12-01

    Inspiratory muscle training (IMT) strengthens the muscles of respiration, improves breathing efficiency, and increases fitness. The IMT is generally performed independently of aerobic exercise; however, it is not clear whether there is added benefit of performing the IMT while simultaneously performing aerobic exercise in terms of activating and strengthening inspiratory muscles. The purpose of our study was to determine the effect of IMT on respiratory muscle electromyography (EMG) activity during stationary cycling in the upright and drops postures as compared with that when the IMT was performed alone. Diaphragm and sternocleidomastoid EMG activity was measured under different resting and cycling postures, with and without the use of the IMT at 40% maximal inspiratory pressure (n = 10; mean age 37). Cycling in an upright posture while simultaneously performing the IMT resulted in a significantly greater diaphragm EMG activity than while performing the IMT at rest in upright or drops postures (p ≤ 0.05). Cycling in drops postures while performing the IMT had a significantly greater diaphragm EMG activity than when performing the IMT at rest in either upright or drops postures (p ≤ 0.05). Sternocleidomastoid muscle activity increased with both cycling and IMT, although posture had little effect. These results support our hypothesis in that the IMT while cycling increases respiratory EMG activity to a significantly greater extent than when performing the IMT solely at rest, suggesting that the combination of IMT and cycling may provide an additive training effect. PMID:26584054

  20. The Life Cycle of Active Region Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Cheung, M. C. M.; van Driel-Gesztelyi, L.; Martínez Pillet, V.; Thompson, M. J.

    2016-08-01

    We present a contemporary view of how solar active region magnetic fields are understood to be generated, transported and dispersed. Empirical trends of active region properties that guide model development are discussed. Physical principles considered important for active region evolution are introduced and advances in modeling are reviewed.

  1. ιHorologi, the first coronal activity cycle in a young solar-like star

    NASA Astrophysics Data System (ADS)

    Sanz-Forcada, J.; Stelzer, B.; Metcalfe, T. S.

    2013-05-01

    Context. The shortest chromospheric (Ca ii H&K) activity cycle (1.6 yr) has been recently discovered in the young (~600 Myr) solar-like star ι Hor. Coronal X-ray activity cycles have only been discovered in a few stars other than the Sun, all of them with an older age and a lower activity level than ι Hor. Aims: We intended to find the X-ray coronal counterpart of the chromospheric cycle for ι Hor. This represents the first X-ray cycle observed in an active star, as well as the paradigm of the first coronal cycles in the life of a solar-like star. Methods: We monitored ι Hor with XMM-Newton observations spanning almost two years. The spectra of each observation are fit with two-temperature coronal models to study the long-term variability of the star. Results: We find a cyclic behavior in X-rays very similar to the contemporaneous chromospheric cycle. The continuous chromospheric monitoring for more than three cycle lengths shows a trend toward decreasing amplitude, apparently modulated by a longer term trend. The second cycle is disrupted prior to reaching its maximum, followed by a brief episode of chaotic variability before the cyclic behavior resumes, only to be disrupted again after slightly more than one cycle. Conclusions: We confirm the presence of an activity cycle of ~1.6 yr in ι Hor both in X-rays and Ca ii H&K. It is likely subject to the modulation of a longer, not yet constrained second cycle. The 1.6 yr cycle is the shortest coronal one observed to date, and ι Hor represents the most active star for which a coronal activity cycle has been found. This cycle is probably representative of the first coronal cycles in the life of a solar-like star, at the age when life started on Earth. Table 2 is available in electronic form at http://www.aanda.org

  2. Birth weight and cognitive function at age 11 years: the Scottish Mental Survey 1932

    PubMed Central

    Shenkin, S; Starr, J; Pattie, A; Rush, M; Whalley, L; Deary, I; PHARAOH, E. P.

    2001-01-01

    AIMS—To examine the relation between birth weight and cognitive function at age 11 years, and to examine whether this relation is independent of social class.
METHODS—Retrospective cohort study based on birth records from 1921 and cognitive function measured while at school at age 11 in 1932.Subjects were 985 live singletons born in the Edinburgh Royal Maternity and Simpson Memorial Hospital in 1921. Moray House Test scores from the Scottish Mental Survey 1932 were traced on 449of these children.
RESULTS—Mean score on Moray House Test increased from 30.6 at a birth weight of <2500 g to 44.7 at 4001-4500 g, after correcting for gestational age, maternal age, parity, social class, and legitimacy of birth. Multiple regression showed that 15.6% of the variance in Moray House Test score is contributed by a combination of social class (6.6%), birth weight (3.8%), child's exact age (2.4%), maternal parity (2.0%), and illegitimacy (1.5%). Structural equation modelling confirmed the independent contribution from each of these variables in predicting cognitive ability. A model in which birth weight acted as a mediator of social class had poor fit statistics.
CONCLUSION—In this 1921 birth cohort, social class and birth weight have independent effects on cognitive function at age 11. Future research will relate these childhood data to health and cognition in old age.

 PMID:11517097

  3. Hydration Deficit in 9- to 11-Year-Old Egyptian Children

    PubMed Central

    Gouda, Zaghloul; Zarea, Mohamed; El-Hennawy, Usama; Viltard, Mélanie; Lepicard, Eve; Hawili, Nasrine; Constant, Florence

    2015-01-01

    Background. Children who drink too little to meet their daily water requirements are likely to become dehydrated, and even mild dehydration can negatively affect health. This is even more important in Middle-Eastern countries where high temperatures increase the risk of dehydration. We assessed morning hydration status in a sample of 519 Egyptian schoolchildren (9-11 years old). Methods. Children completed a questionnaire on breakfast intakes and collected a urine sample after breakfast. Breakfast food and fluid nutritional composition was analyzed and urine osmolality was measured using osmometry. Results. The mean urine osmolality of children was 814 mOsmol/kg: >800 mOsmol/kg (57%) and >1000 mOsmol/kg (24.7%). Furthermore, the results showed that a total water intake of less than 400 mL was associated with a significant higher risk of dehydration. Surprisingly, 63% of the children skipped breakfast. Conclusions. The results showed that a majority of Egyptian schoolchildren arrive at school with a hydration deficit. These results highlight the fact that there is a need to educate schoolchildren about the importance of having a breakfast and adequate hydration. PMID:27335985

  4. Time knowledge acquisition in children aged 6 to 11 years and its relationship with numerical skills.

    PubMed

    Labrell, Florence; Mikaeloff, Yann; Perdry, Hervé; Dellatolas, Georges

    2016-03-01

    Acquisition of time knowledge (TK; the correct representation and use of time units) is linked to the development of numerical abilities, but this relationship has not been investigated in children. The current study examined the acquisition of TK and its association with numerical skills. A total of 105 children aged 6 to 11 years were interviewed with our Time Knowledge Questionnaire (TKQ), developed for purposes of this study, and the Zareki-R, a battery for the evaluation of number processing and mental calculation. The TKQ assessed conventional time knowledge (temporal orientation, temporal sequences, relationships between time units, and telling the time on a clock), estimation of longer durations related to birthday and life span, and estimation of the duration of the interview. Time knowledge increased with age, especially from 6 to 8 years, and was strongly linked to numerical skills. Regression analyses showed that four numerical components were implicated in TK: academic knowledge of numbers and number facts (e.g., reading Arabic numerals, mental calculation), number line estimation (e.g., correspondence between a number and a distance), contextual estimation (e.g., many/few leaves on a tree, children in a family), and numerical tasks involving verbal working memory (e.g., comparison of numbers presented orally). Numerical correlations with TK varied according to children's age; subtests based on academic knowledge of numbers, working memory, and number line estimation were linked with TK in the younger children, but only contextual estimation was associated with TK in the older children. PMID:26590852

  5. Prenatal Cocaine Exposure Alters Cortisol Stress Reactivity in 11 Year Old Children

    PubMed Central

    Lester, Barry M.; LaGasse, Linda L.; Shankaran, Seetha; Bada, Henrietta S.; Bauer, Charles R.; Lin, Richard; Das, Abhik; Higgins, Rosemary

    2011-01-01

    Objective Determine the association between prenatal cocaine exposure and postnatal environmental adversity on salivary cortisol stress reactivity in school aged children. Study design Subjects included 743 11 year old children (n=320 cocaine exposed; 423 comparison) followed since birth in a longitudinal prospective multisite study. Saliva samples were collected to measure cortisol at baseline and after a standardized procedure to induce psychological stress. Children were divided into those who showed an increase in cortisol from baseline to post stress and those who showed a decrease or blunted cortisol response. Covariates measured included site, birthweight, maternal pre and postnatal use of alcohol, tobacco or marijuana, social class, changes in caretakers, maternal depression and psychological symptoms, domestic and community violence, child abuse and quality of the home. Results With adjustment for confounding variables, cortisol reactivity to stress was more likely to be blunted in children with prenatal cocaine exposure. Cocaine exposed children exposed to domestic violence showed the strongest effects. Conclusion The combination of prenatal cocaine exposure and an adverse postnatal environment could down regulate the hypothalamic-pituitary-adrenal axis (HPA) resulting in the blunted cortisol response to stress possibly increasing risk for later psychopathology and adult disease. PMID:20400094

  6. The EPICure Study: Association between Hemodynamics and Lung Function at 11 Years after Extremely Preterm Birth

    PubMed Central

    Bolton, Charlotte E.; Stocks, Janet; Hennessy, Enid; Cockcroft, John R.; Fawke, Joseph; Lum, Sooky; McEniery, Carmel M.; Wilkinson, Ian B.; Marlow, Neil

    2012-01-01

    Objective To investigate the relationship between disturbed lung function and large-artery hemodynamics in school-age children born extremely preterm (EP) (at 25 completed weeks of gestation or less). Study design This was a cross-sectional study of participants from the EPICure study, now aged 11 years (n = 66), and 86 age- and sex-matched term-born classmates. Spirometry parameters (including forced expiratory volume in 1 second), blood pressure, and augmentation index (AIx, a composite of arterial stiffness and global wave reflections) were measured. Results Compared with their classmates, the EP children had significantly impaired lung function, particularly those with neonatal bronchopulmonary dysplasia. Peripheral blood pressure did not differ significantly between the 2 groups, but AIx values were on average 5% higher (95% CI, 2%-8%) in the preterm infants, remaining significant after adjustment for potential confounders. Neonatal bronchopulmonary dysplasia status was not related to AIx. Lung function and maternal smoking were independently associated with AIx; AIx increased by 2.7% per z-score reduction in baseline forced expiratory volume in 1 second and by 4.9% in those whose mothers smoked during pregnancy. Conclusion The independent association between impaired lung function and cardiovascular physiology in early adolescence implies higher cardiovascular risk for children born EP, and suggests that prevention of chronic neonatal lung disease may be a priority in reducing later cardiovascular risk in preterm infants. PMID:22575246

  7. Picky eating during childhood: A longitudinal study to age 11-years

    PubMed Central

    Mascola, Anthony J.; Bryson, Susan W.

    2010-01-01

    Picky eating is a common disorder during childhood often causing considerable parental anxiety. This study examined the incidence, point prevalence, persistence and characteristics of picky eating in a prospective study of 120 children and their parents followed from 2 to 11 years. At any given age between 13% and 22% of the children were reported to be picky eaters. Incidence declined over time whereas point prevalence increased indicating that picky eating is often a chronic problem with 40% having a duration of more than 2-years. Those with longer duration differed from those with short duration having more strong likes and dislikes of food and not accepting new foods. Parents of picky eaters were more likely to report that their children consumed a limited variety of foods, required food prepared in specific ways, expressed stronger likes and dislikes for food, and threw tantrums when denied foods. They were also more likely to report struggles over feeding, preparing special meals, and commenting on their child’s eating. Hence, picky eating is a prevalent concern of parents and may remain so through childhood. It appears to be a relatively stable trait reflecting an individual eating style. However no significant effects on growth were observed. PMID:20850060

  8. Hydration Deficit in 9- to 11-Year-Old Egyptian Children.

    PubMed

    Gouda, Zaghloul; Zarea, Mohamed; El-Hennawy, Usama; Viltard, Mélanie; Lepicard, Eve; Hawili, Nasrine; Constant, Florence

    2015-01-01

    Background. Children who drink too little to meet their daily water requirements are likely to become dehydrated, and even mild dehydration can negatively affect health. This is even more important in Middle-Eastern countries where high temperatures increase the risk of dehydration. We assessed morning hydration status in a sample of 519 Egyptian schoolchildren (9-11 years old). Methods. Children completed a questionnaire on breakfast intakes and collected a urine sample after breakfast. Breakfast food and fluid nutritional composition was analyzed and urine osmolality was measured using osmometry. Results. The mean urine osmolality of children was 814 mOsmol/kg: >800 mOsmol/kg (57%) and >1000 mOsmol/kg (24.7%). Furthermore, the results showed that a total water intake of less than 400 mL was associated with a significant higher risk of dehydration. Surprisingly, 63% of the children skipped breakfast. Conclusions. The results showed that a majority of Egyptian schoolchildren arrive at school with a hydration deficit. These results highlight the fact that there is a need to educate schoolchildren about the importance of having a breakfast and adequate hydration. PMID:27335985

  9. Anemia and Iron Deficiency in Vietnamese Children, 6 to 11 Years Old.

    PubMed

    Le Nguyen Bao, Khanh; Tran Thuy, Nga; Nguyen Huu, Chinh; Khouw, Ilse; Deurenberg, Paul

    2016-07-01

    In a population sample of 385 children, 6 to 11 years old, venous blood parameters-hemoglobin (Hb), ferritin, red blood cell count (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), C-reactive protein (CRP), and α1-acid glycoprotein (AGP)-were determined to get insight into the iron status. The prevalence of anemia was 11.4%; 5.6% had iron deficiency (ID), whereas 0.4% had ID anemia. Correction for inflammation based on CRP and AGP did not markedly change the overall prevalence of ID and ID anemia. Stunted children had lower Hb and ferritin values compared with nonstunted children, and thin children had lower values compared with normal-weight or overweight and obese children. Many nonanemic children had alert values for RBC, MCV, MCH, and MCHC. It is concluded that although the prevalence of anemia is of the magnitude of a mild public health problem, the iron status of many nonanemic children is borderline, as indicated by a high number of children with low values for red blood cytology. PMID:27052301

  10. Facial reconstruction of an 11-year-old female resident of 430 BC Athens.

    PubMed

    Papagrigorakis, Manolis J; Synodinos, Philippos N; Antoniadis, Aristomenis; Maravelakis, Emmanuel; Toulas, Panagiotis; Nilsson, Oscar; Baziotopoulou-Valavani, Effie

    2011-01-01

    Although modern standards of ideal proportions and facial esthetics are based mostly on observations of human faces as depicted in Classical Greek masterpieces of art, the real faces of ordinary ancient Greeks have, until now, remained elusive and subject to the imagination. Objective forensic techniques of facial reconstruction have never been applied before, because human skeletal material from Classical Greece has been extremely scarce, since most decent burials of that time required cremation. Here, the authors show stage by stage the facial reconstruction of an 11-year-old girl whose skull was unearthed in excellent condition from a mass grave with victims of the Plague that struck Athens of 430 bc. The original skull was replicated via three-dimensional modeling and rapid prototyping techniques. The reconstruction followed the Manchester method, laying the facial tissues from the surface of the skull outward by using depth-marker pegs as thickness guides. The shape, size, and position of the eyes, ears, nose, and mouth were determined according to features of the underlying skeletal tissues, whereas the hairstyle followed the fashion of the time. This is the first case of facial reconstruction of a layperson residing in Athens of the Golden Age of Pericles. It is ironic, however, that this unfortunate girl who lived such a short life in ancient Athens, will now, 2500 years later, have the chance to travel and be universally recognizable in a world much bigger than anybody in ancient Athens could have ever imagined. PMID:20936971

  11. Diagnosis and Treatment of Odontogenic Cutaneous Sinus Tracts in an 11-Year-Old Boy

    PubMed Central

    Chen, Ke; Liang, Yun; Xiong, Huacui

    2016-01-01

    Abstract Odontogenic cutaneous sinus tracts (OCSTs) are generally primarily misdiagnosed and inappropriately treated by virtue of their rarity and the absence of dental symptoms. Accurate diagnosis and treatment and the elimination of the source of infection can reduce the incidence of complications and relieve the pain of the patient. In this case report, we present the case of an 11-year-old patient with an apparent abscess but an unobvious draining sinus tract in his left cheek. Intraorally, a glass-ionomer-cement filling on the occlusal surface of the left mandibular first molar (tooth 36) was noted. Radiographic examination revealed a radiopaque mass inside the crown and pulp chamber and an irregular, radiolucent periapical lesion surrounding the distal root apex. He was diagnosed with an OCTS secondary to a periapical abscess of tooth 36. Precise root canal therapy (RCT) and chronic granuloma debridement was performed; 6 months later, the abscess and sinus had healed completely, and the periapical lesion had resolved. Odontogenic cutaneous sinus tracts are uncommon in the clinic. This case report reminds us of the significance of OCSTs and provides some implications for their diagnosis and treatment. PMID:27196471

  12. Sludge accumulation in shallow maturation ponds treating UASB reactor effluent: results after 11 years of operation.

    PubMed

    Possmoser-Nascimento, Thiago Emanuel; Rodrigues, Valéria Antônia Justino; von Sperling, Marcos; Vasel, Jean-Luc

    2014-01-01

    Polishing ponds are natural systems used for the post-treatment of upflow anaerobic sludge blanket (UASB) effluents. They are designed as maturation ponds and their main goal is the removal of pathogens and nitrogen and an additional removal of residual organic matter from the UASB reactor. This study aimed to evaluate organic matter and suspended solids removal as well as sludge accumulation in two shallow polishing ponds in series treating sanitary effluent from a UASB reactor with a population equivalent of 200 inhabitants in Brazil, operating since 2002. For this evaluation, long-term monitoring of biochemical oxygen demand and total suspended solids and bathymetric surveys have been undertaken. The ponds showed an irregular distribution of total solids mass in the sludge layer of the two ponds, with mean accumulation values of 0.020 m(3) person(-1) year(-1) and 0.004 m(3) person(-1) year(-1) in Ponds 1 and 2, leading to around 40% and 8% of the liquid volume occupied by the sediments after 11 years of operation. The first pond showed better efficiency in relation to organic matter removal, although its contribution was limited, due to algal growth. No simple input-output mass balance of solids can be applied to the ponds due to algal growth in the liquid phase and sludge digestion in the sludge.

  13. Physical training improves body composition of black obese 7- to 11-year-old girls.

    PubMed

    Gutin, B; Cucuzzo, N; Islam, S; Smith, C; Moffatt, R; Pargman, D

    1995-07-01

    We determined the effect of supervised physical training without dietary intervention, on body composition of obese girls. The subjects were 25 obese 7- to 11-year-old black girls, divided into physical training and lifestyle education groups which were comparable on baseline body composition; 22 girls finished all aspects of the study. Twelve girls engaged in aerobic training (10 weeks, 5 days/week) while 10 engaged in weekly lifestyle discussions without formal physical training. Total body and regional body composition were measured with dual energy x-ray absorptiometry, skinfolds and circumferences. Aerobic fitness was measured by heart rate response to submaximal treadmill exercise. The physical training group attended 94% of scheduled sessions and kept their heart rates at an average of 163 bpm for 28 minutes/session. The lifestyle group attended 95% of their sessions; they remained stable in aerobic fitness and most body composition measurements. The physical training group showed a significant improvement in aerobic fitness and a significant decline of 1.4% body fat. Skinfold and circumference indices of fatness also declined significantly in the training group. We conclude that controlled physical training, without dietary intervention, improved the fitness and body composition of obese black girls.

  14. Leg muscle activation and distance setting of the leg cycle ergometer for use by the elderly.

    PubMed

    Kim, Seon-Chill; Lee, Sang-Yeol; Lee, Young-Ik

    2014-10-01

    [Purpose] This study verified the leg muscle activities of elderly subjects performing leg cycle ergometer exercise. [Subjects] Forty-one elderly persons were the subjects of this study. [Methods] For the three distances corresponding to knee flexion angles of 15, 45, and 70, the muscle activities of the rectus femoris, biceps femoris, tibialis anterior and lateral gastrocnemius were measured while the subjects exercised on a cycle ergometer. [Results] The rectus femoris and biceps femoris showed statistically significant increases as the distance between the cycle ergometer and the body increased, and the lateral gastrocnemius muscle activation showed a statistically significant increase as the distance from the body to the cycle ergometer decreased. [Conclusion] When the elderly have limb muscle weakness, leg cycle ergometer distances should be adjusted.

  15. Rhinosporidium seeberi Nuclear Cycle Activities Using Confocal Microscopy.

    PubMed

    Delfino, Darly; Mendoza, Leonel; Vilela, Raquel

    2016-02-01

    Rhinosporidium seeberi is an uncultivated Ichthyosporean infecting animals, including humans. Recent studies suggested R. seeberi undergoes synchronized nuclear division without cytokinesis. We used confocal microscopy to investigate R. seeberi nuclear division cycles in formalin-fixed tissues stained with DAPI and phalloidin. We report that R. seeberi nuclei in juvenile and intermediary sporangia synchronously divided without cytokinesis. Intermediary sporangia display numerous 3-4 μm nuclei at different mitotic stages as well as a thick inner layer with strong affinity for phalloidin. Mature sporangia showed numerous 5-12 μm cell-walled endospores, each containing a 2-4 μm in diameter nucleus. Phalloidin did not bind to the inner layers of mature sporangia or endospores. The development of a "germinative zone" in the inner layer of mature sporangia containing hundreds of nuclei was also confirmed. This study establishes that during the R. seeberi life cycle synchronous nuclear divisions without cytokinesis takes place, resulting in the formation of thousands of nuclei. Cytokinesis, on the other hand, is a 1-time event and occurs in the latest stages of intermediate sporangia, after the formation of thousands of nuclei and just before mature sporangia development. PMID:26461427

  16. On the Relationship of the Energy Spectrum Indexes of the 11-Year Variation of Galactic Cosmic Rays and the Interplanetary Magnetic Field Strength Fluctuations

    NASA Astrophysics Data System (ADS)

    Alania, M. V.; Iskra, K.; Modzelewska, R.; Siluszyk, M.

    2003-07-01

    Data of neutron super monitors and interplanetary magnetic field (IMF) have been used to find a relationship between the temporal changes of galactic cosmic rays (GCR) isotropic intensity variations energy spectrum index γ (δ D/D(R) ∝ R-γ , where R is the rigidity of GCR particles) and the exponent ( of the power spectral density (PSD) of the IMF's strength fluctuations (PSD ∝ f-ν , where f is the frequency). INTRODUCTION. The 11-year variation of GCR is generally related with the similar variation of solar activity (SA) [1-5]. Up to present it is not well established which of parameters or group of parameters of SA and of the solar wind are responsible for the 11-year variation of GCR. To answer to this question it is necessary to estimate the separate contributions of each processes — convection, diffusion, drift and energy changes of GCR due to the interaction with the solar wind. However, all above mentioned processes are interconnected and an estimation of the roles of each separate processes contains some uncertainties. Regarding contributions of all above mentioned processes in the formation of the 11-year variation of GCR the special role is ascrib ed to the varying character of the diffusion from the minima to the maxima epochs of SA. It was noted [6-8] that the exponent γ of GCR isotropic intensity variations (δ D(R)/D (R) = AR-γ , where R is the GCR particle's rigidity and A is he power) could be considered as one of the important indices for the explanation of the 11-year variation of GCR for the energy more than 1 GeV.

  17. Cycling for Students with ASD: Self-Regulation Promotes Sustained Physical Activity

    ERIC Educational Resources Information Center

    Todd, Teri; Reid, Greg; Butler-Kisber, Lynn

    2010-01-01

    Individuals with autism often lack motivation to engage in sustained physical activity. Three adolescents with severe autism participated in a 16-week program and each regularly completed 30 min of cycling at the end of program. This study investigated the effect of a self-regulation instructional strategy on sustained cycling, which included…

  18. Skin donors and human skin allografts: evaluation of an 11-year practice and discard in a referral tissue bank.

    PubMed

    Gaucher, Sonia; Khaznadar, Zena; Gourevitch, Jean-Claude; Jarraya, Mohamed

    2016-03-01

    The Saint Louis hospital tissue bank provides skin allografts to pediatric and adult burn units in the Paris area. The aim of this study was to analyze our activity during the last 11 years focusing on the reasons for skin discard. Skin is procured solely from the back of the body, which is divided into 10 zones that are harvested and processed separately. This retrospective study included all skin donors harvested between June 2002 and June 2013, representing a total of 336 donors and 2770 zones. The donors were multiorgan heart-beating donors in 91 % of cases (n = 307). The main reason for discarding harvested skin was microbial contamination, detected in 99 donors (29 %). Most contaminants were of low pathogenicity. Other reasons for discard included positive serologic tests for 2 donors [17 zones (0.61 %)], unsuitable physical skin characteristics for 3 zones (0.11 %), the donor's medical history for 53 zones (1.91 %), and technical issues with processing or distribution for 61 zones (2.2 %). In our experience, microbial contamination continues to be the main reason for discarding potential skin allografts. However, discards are limited by separate harvesting and processing of multiple zones in each donor. PMID:26275343

  19. [Drowning versus cardiac ischemia: Cardiac arrest of an 11-year-old boy at a swimming lake].

    PubMed

    Födinger, A; Wöss, C; Semsroth, S; Stadlbauer, K H; Wenzel, V

    2015-11-01

    This report describes a case of sudden cardiac arrest and subsequent attempted cardiopulmonary resuscitation of an 11-year-old child on the shores of a swimming lake. Reports of eyewitnesses excluded the obviously suspected diagnosis of a drowning accident. The result of the autopsy was sudden cardiac death due to a congenital coronary anomaly (abnormal left coronary artery, ALCA). Favored by vigorous physical activity, this anomaly can lead to malignant arrhythmias because the ectopic coronary artery with its intramural course through the aortic wall is compressed during every systole. This pathology was not known to the boy or his family; in fact he liked sports but had suffered of a syncope once which was not followed up. Without a strong suspicion it is difficult to diagnose a coronary artery anomaly and it is often missed even in college athletes. Tragically, sudden cardiac arrest may be the first symptom of an undiagnosed abnormal coronary artery. Following syncope or chest pain during exercise with a normal electrocardiogram (ECG) cardiac imaging, such as computed tomography (CT) or angiography should be initiated in order to enable surgical repair of an abnormal coronary artery.

  20. Possible chromospheric activity cycles in II Peg, UX Ari and V711 Tau

    NASA Astrophysics Data System (ADS)

    Buccino, Andrea P.; Mauas, Pablo J. D.

    2009-02-01

    We study the Mount Wilson indices we obtained indirectly from IUE high and low resolution spectra of the RS CVn-type systems II Peg (K2IV), UX Ari (K0IV+G5V) and V711 Tau (K1IV+G5V), extensively observed by IUE from 1978 to 1996. We analyze the activity signatures, which correspond to the primary star, with the Lomb-Scargle periodogram. From the analysis of V711 Tau data, we found a possible chromospheric cycle with a period of 18 years and a shorter ~3 year cycle, which could be associated to a chromospheric flip-flop cycle. The data of II Peg also suggest a chromospheric cycle of ~21 years and a flip-flop cycle of ~9 years. Finally, we obtained a possible chromospheric cycle of ~6 years for UX Ari.

  1. Association between obesity and asthma in 4-11 year old children in the UK

    PubMed Central

    Figueroa-Munoz, J; Chinn, S; Rona, R

    2001-01-01

    BACKGROUND—There is evidence of a positive association between asthma and obesity in adults and in children. We investigated, in a large sample of English and Scottish primary school children, whether there is a consistent association between fatness and asthma symptoms in Britain.
METHODS—A cross sectional analysis was made of 18 218 children aged 4-11 years who participated in the 1993 or 1994 surveys of the National Study of Health and Growth (NSHG). Children belonged either to English or Scottish representative samples, or an English inner city sample. Asthma attacks in the previous year, occasional wheeze, or persistent wheeze were the symptoms used in the analysis. Body mass index (BMI) and the sum of triceps and subscapular skinfolds converted to standard deviation scores (SDS) were used to assess levels of fatness.
RESULTS—A total of 14 908 children (81.8%) were included in the analysis. In the multiple logistic analysis BMI and asthma (asthma attacks or wheeze) were associated in the representative sample (OR for the comparison of the 10th and 90th centiles of BMI 1.28,95% CI 1.11 to 1.48), but sum of skinfolds was unrelated to asthma symptoms in most analyses. The association between asthma and BMI was stronger in girls than in boys in the inner city sample, but less convincingly in the representative sample.
CONCLUSIONS—Levels of obesity are associated with asthma symptoms regardless of ethnicity. The association is more consistent for BMI than for sum of skinfolds, partly because obese children are more advanced in their maturation than other children. There is some evidence that, as in adults, the association is stronger in girls than in boys, but only in the multiethnic inner city sample.

 PMID:11209102

  2. Manual Control Age and Sex Differences in 4 to 11 Year Old Children

    PubMed Central

    Flatters, Ian; Hill, Liam J. B.; Williams, Justin H. G.; Barber, Sally E.; Mon-Williams, Mark

    2014-01-01

    To what degree does being male or female influence the development of manual skills in pre-pubescent children? This question is important because of the emphasis placed on developing important new manual skills during this period of a child's education (e.g. writing, drawing, using computers). We investigated age and sex-differences in the ability of 422 children to control a handheld stylus. A task battery deployed using tablet PC technology presented interactive visual targets on a computer screen whilst simultaneously recording participant's objective kinematic responses, via their interactions with the on-screen stimuli using the handheld stylus. The battery required children use the stylus to: (i) make a series of aiming movements, (ii) trace a series of abstract shapes and (iii) track a moving object. The tasks were not familiar to the children, allowing measurement of a general ability that might be meaningfully labelled ‘manual control’, whilst minimising culturally determined differences in experience (as much as possible). A reliable interaction between sex and age was found on the aiming task, with girls' movement times being faster than boys in younger age groups (e.g. 4–5 years) but with this pattern reversing in older children (10–11 years). The improved performance in older boys on the aiming task is consistent with prior evidence of a male advantage for gross-motor aiming tasks, which begins to emerge during adolescence. A small but reliable sex difference was found in tracing skill, with girls showing a slightly higher level of performance than boys irrespective of age. There were no reliable sex differences between boys and girls on the tracking task. Overall, the findings suggest that prepubescent girls are more likely to have superior manual control abilities for performing novel tasks. However, these small population differences do not suggest that the sexes require different educational support whilst developing their manual skills

  3. Nutritional anaemia in 11-year-old schoolchildren in the western Cape.

    PubMed

    Lamparelli, R D; van der Westhuyzen, J; Steyn, N P; Baynes, R D; MacFarlane, B J; Green, A; Bothwell, T H

    1988-04-16

    A nutritional anaemia survey was carried out on 610 11-year-old coloured, black and white schoolchildren in urban and rural communities in the western Cape. The mean (+/- 1 SD) haemoglobin concentration was 13.0 +/- 1.2 g/dl. The coloured and black subgroups considered together had a significantly lower mean haemoglobin concentration than the white subgroup (12.8 +/- 1.2 g/dl v. 13.4 +/- 1.0 g/dl) (F = 37.47; P less than 0.0001). The urban population as a whole had a significantly lower geometric mean (1 SD range) serum ferritin concentration than the rural population (25.6 (13.5-48.6) micrograms/l v. 34.1 (21.3-54.6) micrograms/l) (F = 42.94; P less than 0.0001). The lowest geometric mean serum ferritin values were found in the urban coloured (23.1 (11.5-46.4) micrograms/l) and urban black schoolchildren (23.7 (13.2-42.6) micrograms/l), with figures of less than 12 micrograms/l in 11.7% and 12.5% respectively. Although 28% of the children had red cell folate values below the recommended lower limit of normal (175 ng/ml), probability plot analysis of the data suggested that folate deficiency was not a major problem in the study population. The calculated daily iron and folate intakes were below the age-related recommended dietary allowance (RDA) in all the subgroups, yet anaemia was relatively uncommon. These findings suggest that the RDA values are too high. Overall the prevalence of nutritional anaemia was low and only the urban coloured subgroup showed significant second populations with low haemoglobin and serum ferritin measurements.

  4. Levels of selected urinary metabolites of volatile organic compounds among children aged 6-11 years.

    PubMed

    Jain, Ram B

    2015-10-01

    Data from National Health and Nutrition Examination Survey for the years 2011-2012 were used to evaluate variability in the observed levels of 20 urinary metabolites of volatile organic compounds (VOCs) by age, gender, and race/ethnicity among children aged 6-11 years. Exposure to environmental tobacco smoke was positively associated with the levels of selected metabolites of acrylonitrile, 1,3-butadiene, cyanide, and propylene oxide in a dose-response manner. Levels of the selected metabolites of acrolein, acrylonitrile, 1,3-butadiene, styrene, toluene, and xylene decreased with increase in age. Levels of 1-bromopropane decreased with number of rooms in the house but the reverse was true for 1,3-butadiene, carbon-disulfide, and N,N-dimethylformamide. Levels of most of the 20 metabolites did not vary with gender. Non-Hispanic white children had higher adjusted levels of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA), N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC), and phenylglyoxylic acid (PGA) than non-Hispanic black children. Non-Hispanic white children had statistically significantly higher adjusted levels of N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA), trans, trans-Muconic acid (MU), and N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC) than non-Hispanic Asian children but statistically significantly lower levels of N-Acetyl-S-(n-propyl)-L-cysteine (BPMA) than non-Hispanic Asian children. Non-Hispanic Asian children had the lowest levels of 13 of the 20 metabolites among four major racial/ethnic groups but highest levels for three metabolites. For selected metabolites of acrolein, acrylamide, acrylonitrile-vinyl chloride-ethylene oxide, benzene, 1,3-butadien, crotonaldehyde, cyanide, ethylbenzene-styrene, and toluene, children had statistically significantly higher levels than nonsmoking adults. These results demonstrate how vulnerable children are to being exposed to harmful chemicals like VOCs in their own homes. PMID:26257031

  5. Illegal Substance Use among Italian High School Students: Trends over 11 Years (1999–2009)

    PubMed Central

    Molinaro, Sabrina; Siciliano, Valeria; Curzio, Olivia; Denoth, Francesca; Salvadori, Stefano; Mariani, Fabio

    2011-01-01

    Purpose To monitor changes in habits in drug use among Italian high school students. Methods Cross-sectional European School Survey Project on Alcohol and Other Drugs (ESPAD) carried out in Italy annually for 11 years (1999–2009) with representative samples of youth attending high school. The sample size considered ranges from 15,752 to 41,365 students and response rate ranged from 85.5% to 98.6%. Data were analyzed to obtain measures of life-time prevalence (LT), use in the last year (LY), use in the last 30 days (LM), frequent use. Comparisons utilized difference in proportion tests. Tests for linear trends in proportion were performed using the Royston p trend test. Results When the time-averaged value was considered, cannabis (30% LT) was the most, and heroin the least (2%) frequently used, with cocaine (5%), hallucinogens (2%) and stimulants (2%) in between. A clear gender gap is evident for all drugs, more obvious for hallucinogens (average M/F LY prevalence ratio 2, range 1.7–2.4, p<0.05), less for cannabis (average M/F LY prevalence ratio 1.3, range 1.2–1.5, p<0.05). Data shows a change in trend between 2005 and 2008; in 2006 the trend for cannabis use and availability dropped and the price rose, while from 2005 cocaine and stimulant use prevalence showed a substantial increase and the price went down. After 2008 use of all substances seems to have decreased. Conclusions Drug use is widespread among students in Italy, with cannabis being the most and heroin the least prevalent. Girls are less vulnerable than boys to illegal drug use. In recent years, a decrease in heroin use is overbalanced by a marked rise in hallucinogen and stimulant use. PMID:21695199

  6. Drunkenness and heavy drinking among 11year olds - Findings from the UK Millennium Cohort Study.

    PubMed

    Kelly, Yvonne; Britton, Annie; Cable, Noriko; Sacker, Amanda; Watt, Richard G

    2016-09-01

    Heavy drinking among young people is linked to negative consequences including other risky behaviours, educational failure and premature mortality. There is a lack of research examining factors that influence heavy and binge drinking in early adolescence as prior work has focused on older teenagers. The objective of this paper was to identify individual and family factors associated with drunkenness and episodes of heavy drinking in early adolescence. We analysed data on 11,046 11year olds from the UK Millennium Cohort Study. Multivariate logistic regression was used to estimate odds ratios for associations. 1.2% of participants reported having been drunk, and 0.6% reported having had 5 or more drinks in a single episode. Participants who reported drunkenness were more likely to be boys (1.6% vs 0.7%, p<0.01), to have socioemotional difficulties (2.6% vs 1.0%, p<0.001), to report antisocial behaviours (none=0.6%, 1=2.0%, 2 or more=7.0%, p<0.001), report truancy (6.0% vs 1.0%, p<0.001), smoke cigarettes (12.0% vs 0.8%, p<0.001). Parental drinking did not appear to be associated with the odds of drunkenness. Associated with higher odds of drunkenness were: having friends who drank (OR=5.17); having positive expectancies towards alcohol (OR 2+=2.02); ever having smoked cigarettes (OR=5.32); the mother-child relationship not being close (OR=2.17). Associated with a reduced odds of drunkenness was having a heightened perception of harm from drinking 1-2 drinks daily (OR - some risk=0.48, great risk=0.40). Our findings support policies aimed at multiple levels, starting in the preadolescent years, which incorporate individual, family, and peer factors. PMID:27413004

  7. Impact of Clinical Pharmacist on the Pediatric Intensive Care Practice: An 11-Year Tertiary Center Experience

    PubMed Central

    Crabtree, Heidi M.; Fryer, Karen R.; Graner, Kevin K.; Arteaga, Grace M.

    2015-01-01

    OBJECTIVES: With increasing complexity of critical care medicine comes an increasing need for multidisciplinary involvement in care. In many institutions, pharmacists are an integral part of this team, but long-term data on the interventions performed by pharmacists and their effects on patient care and outcomes are limited. We aimed to describe the role of pediatric clinical pharmacists in pediatric intensive care unit (PICU) practice. METHODS: We retrospectively reviewed the records of pharmacy interventions in the PICU at the Mayo Clinic in Rochester, Minnesota, from 2003-2013, with a distinct period of increased pharmacist presence in the PICU from 2008 onward. We compared demographic and outcome data on patients who did and who did not have pharmacy interventions during 2 periods (2003–2007 and 2008–2013). RESULTS: We identified 27,773 total interventions by pharmacists during the 11-year period, of which 79.8% were accepted by the clinical team. These interventions were made on 10,963 unique PICU admissions and prevented 5867 order entry errors. Pharmacists' interventions increased year over year, including a significant change in 2008. Patients who required pharmacy involvement were younger, sicker, and had longer intensive care unit, hospital, and ventilator duration. Average central line infections and central line entry rates decreased significantly over the study period. CONCLUSIONS: Increased pharmacist presence in the PICU is associated with increased interventions and prevention of adverse drug events. Pharmacist participation during rounds and order entry substantially improved the care of critically sick children and should be encouraged. PMID:26380569

  8. Levels of selected urinary metabolites of volatile organic compounds among children aged 6-11 years.

    PubMed

    Jain, Ram B

    2015-10-01

    Data from National Health and Nutrition Examination Survey for the years 2011-2012 were used to evaluate variability in the observed levels of 20 urinary metabolites of volatile organic compounds (VOCs) by age, gender, and race/ethnicity among children aged 6-11 years. Exposure to environmental tobacco smoke was positively associated with the levels of selected metabolites of acrylonitrile, 1,3-butadiene, cyanide, and propylene oxide in a dose-response manner. Levels of the selected metabolites of acrolein, acrylonitrile, 1,3-butadiene, styrene, toluene, and xylene decreased with increase in age. Levels of 1-bromopropane decreased with number of rooms in the house but the reverse was true for 1,3-butadiene, carbon-disulfide, and N,N-dimethylformamide. Levels of most of the 20 metabolites did not vary with gender. Non-Hispanic white children had higher adjusted levels of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA), N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC), and phenylglyoxylic acid (PGA) than non-Hispanic black children. Non-Hispanic white children had statistically significantly higher adjusted levels of N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA), trans, trans-Muconic acid (MU), and N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC) than non-Hispanic Asian children but statistically significantly lower levels of N-Acetyl-S-(n-propyl)-L-cysteine (BPMA) than non-Hispanic Asian children. Non-Hispanic Asian children had the lowest levels of 13 of the 20 metabolites among four major racial/ethnic groups but highest levels for three metabolites. For selected metabolites of acrolein, acrylamide, acrylonitrile-vinyl chloride-ethylene oxide, benzene, 1,3-butadien, crotonaldehyde, cyanide, ethylbenzene-styrene, and toluene, children had statistically significantly higher levels than nonsmoking adults. These results demonstrate how vulnerable children are to being exposed to harmful chemicals like VOCs in their own homes.

  9. A 22-yrs Hurricane Cycle and its Relation to Geomagnetic Activity

    NASA Astrophysics Data System (ADS)

    Mendoza, Blanca; Pazos, Marni

    Applying spectral analysis to the Atlantic and Pacific hurricane time series, we found period-icities that coincide with the main sunspot and magnetic solar cycles. To assess the possibility that these periodicities could be associated to solar activity, we obtain correlations between hurricane occurrence and several solar activity-related phenomena, such as the total solar irra-diance, the cosmic ray flux and the Dst index of geomagnetic activity. Our results indicate that the highest significant correlations are found between the Atlantic and Pacific hurricanes and the Dst index. Most importantly, both oceans present the highest hurricane-Dst correlations during the ascending part of odd solar cycles and the descending phase of even solar cycles. This shows not only the existence of a 22yrs cycle but also the nature of such periodicity. Fur-thermore, we found that the Atlantic hurricanes behave differently from the Pacific hurricanes in relation to the solar activity-related disturbances considered.

  10. Magnetic Tilts and Polarity Separations in Sunspot Groups and Active Regions the Cycle 23

    NASA Astrophysics Data System (ADS)

    Zharkov, S. I.; Zharkova, V. V.

    2006-08-01

    We present the analysis of magnetic tilts in active regions and sunspot groups for 1996-2005 that are automatically extracted from the Solar Feature Catalogues (http://solar.inf.brad.ac.uk ). We investigate the statistical variations of magnetic field tilt in sunspot groups and whole active regions, their longitudinal and latitudinal distributions, drifts and daily polarity separation during different phases of the solar cycle 23. The classification results are compared with the similar research for the previous cycles and the specifics on the cycle 23 is discussed in conjunction to the solar dynamo theory.

  11. Frowning and Jaw Clenching Muscle Activity Reflects the Perception of Effort During Incremental Workload Cycling

    PubMed Central

    Huang, Ding-Hau; Chou, Shih-Wei; Chen, Yi-Lang; Chiou, Wen-Ko

    2014-01-01

    The present study aimed to investigate whether facial electromyography (EMG) recordings reflect the perception of effort and primary active lower limb muscle activity during incremental workload cycling. The effects of exercise intensity on EMG activity of the corrugator supercilii (CS), masseter and vastus lateralis (VL) muscles, heart rate (HR) and the rating of perceived exertion (RPE) were investigated, and the correlations among these parameters were determined. Eighteen males and 15 females performed continuous incremental workload cycling exercise until exhaustion. CS, masseter and VL muscle activities were continuously recorded using EMG during exercise. HR was also continuously monitored during the test. During the final 30 s of each stage of cycle ergometer exercise, participants were asked to report their feeling of exertion on the adult OMNI-Cycle RPE. HR and EMG activity of the facial muscles and the primary active lower limb muscle were strongly correlated with RPE; they increased with power output. Furthermore, facial muscle activity increased significantly during high-intensity exercise. Masseter muscle activity was strongly and positively correlated with HR, RPE and VL activity. The present investigation supports the view that facial EMG activity reflects the perception of effort. The jaw clenching facial expression can be considered an important factor for improving the reporting of perceived effort during high-intensity exercise in males and females. Key points Frowning and jaw clenching muscle activity reflects the perception of effort during incremental workload cycling. EMG activity of the masseter muscle was strongly and positively correlated with RPE, HR and lower limb EMG activity during incremental workload cycling. The jaw clenching facial expression can be considered an important factor for estimating the intensity of effort. PMID:25435786

  12. Viral activities and life cycles in deep subseafloor sediments.

    PubMed

    Engelhardt, Tim; Orsi, William D; Jørgensen, Bo Barker

    2015-12-01

    Viruses are highly abundant in marine subsurface sediments and can even exceed the number of prokaryotes. However, their activity and quantitative impact on microbial populations are still poorly understood. Here, we use gene expression data from published continental margin subseafloor metatranscriptomes to qualitatively assess viral diversity and activity in sediments up to 159 metres below seafloor (mbsf). Mining of the metatranscriptomic data revealed 4651 representative viral homologues (RVHs), representing 2.2% of all metatranscriptome sequence reads, which have close translated homology (average 77%, range 60-97% amino acid identity) to viral proteins. Archaea-infecting RVHs are exclusively detected in the upper 30 mbsf, whereas RVHs for filamentous inoviruses predominate in the deepest sediment layers. RVHs indicative of lysogenic phage-host interactions and lytic activity, notably cell lysis, are detected at all analysed depths and suggest a dynamic virus-host association in the marine deep biosphere studied here. Ongoing lytic viral activity is further indicated by the expression of clustered, regularly interspaced, short palindromic repeat-associated cascade genes involved in cellular defence against viral attacks. The data indicate the activity of viruses in subsurface sediment of the Peruvian margin and suggest that viruses indeed cause cell mortality and may play an important role in the turnover of subseafloor microbial biomass. PMID:26109514

  13. Viral activities and life cycles in deep subseafloor sediments.

    PubMed

    Engelhardt, Tim; Orsi, William D; Jørgensen, Bo Barker

    2015-12-01

    Viruses are highly abundant in marine subsurface sediments and can even exceed the number of prokaryotes. However, their activity and quantitative impact on microbial populations are still poorly understood. Here, we use gene expression data from published continental margin subseafloor metatranscriptomes to qualitatively assess viral diversity and activity in sediments up to 159 metres below seafloor (mbsf). Mining of the metatranscriptomic data revealed 4651 representative viral homologues (RVHs), representing 2.2% of all metatranscriptome sequence reads, which have close translated homology (average 77%, range 60-97% amino acid identity) to viral proteins. Archaea-infecting RVHs are exclusively detected in the upper 30 mbsf, whereas RVHs for filamentous inoviruses predominate in the deepest sediment layers. RVHs indicative of lysogenic phage-host interactions and lytic activity, notably cell lysis, are detected at all analysed depths and suggest a dynamic virus-host association in the marine deep biosphere studied here. Ongoing lytic viral activity is further indicated by the expression of clustered, regularly interspaced, short palindromic repeat-associated cascade genes involved in cellular defence against viral attacks. The data indicate the activity of viruses in subsurface sediment of the Peruvian margin and suggest that viruses indeed cause cell mortality and may play an important role in the turnover of subseafloor microbial biomass.

  14. A cell cycle-controlled redox switch regulates the topoisomerase IV activity

    PubMed Central

    Narayanan, Sharath; Janakiraman, Balaganesh; Kumar, Lokesh

    2015-01-01

    Topoisomerase IV (topo IV), an essential factor during chromosome segregation, resolves the catenated chromosomes at the end of each replication cycle. How the decatenating activity of the topo IV is regulated during the early stages of the chromosome cycle despite being in continuous association with the chromosome remains poorly understood. Here we report a novel cell cycle-regulated protein in Caulobacter crescentus, NstA (negative switch for topo IV decatenation activity), that inhibits the decatenation activity of the topo IV during early stages of the cell cycle. We demonstrate that in C. crescentus, NstA acts by binding to the ParC DNA-binding subunit of topo IV. Most importantly, we uncover a dynamic oscillation of the intracellular redox state during the cell cycle, which correlates with and controls NstA activity. Thus, we propose that predetermined dynamic intracellular redox fluctuations may act as a global regulatory switch to control cellular development and cell cycle progression and may help retain pathogens in a suitable cell cycle state when encountering redox stress from the host immune response. PMID:26063575

  15. Effect of a school-based intervention to promote healthy lifestyles in 7–11 year old children

    PubMed Central

    Gorely, Trish; Nevill, Mary E; Morris, John G; Stensel, David J; Nevill, Alan

    2009-01-01

    Background Physical inactivity is recognised as a public health concern within children and interventions to increase physical activity are needed. The purpose of this research was to evaluate the effect of a school-based healthy lifestyles intervention on physical activity, fruit and vegetable consumption, body composition, knowledge, and psychological variables. Method A non-randomised controlled study involving 8 primary schools (4 intervention, 4 control). Participants were 589 children aged 7–11 years. The intervention lasted 10 months and comprised a CD-rom learning and teaching resource for teachers; an interactive website for pupils, teachers and parents; two highlight physical activity events (1 mile school runs/walks); a local media campaign; and a summer activity wall planner and record. Primary outcome measures were objectively measured physical activity (pedometers and accelerometers) and fruit and vegetable consumption. Secondary outcomes included body mass index, waist circumference, estimated percent body fat, knowledge, psychological variables. Multi-level modelling was employed for the data analysis. Results Relative to children in control schools, those in intervention schools significantly increased their total time in moderate-to-vigorous physical activity (MVPA) (by 9 minutes/day vs a decrease of 10 minutes/day), their time in MVPA bouts lasting at least one minute (10 minutes/day increase vs no change) and increased daily steps (3059 steps per day increase vs 1527 steps per day increase). A similar pattern of results was seen in a subset of the least active participants at baseline. Older participants in intervention schools showed a significant slowing in the rate of increase in estimated percent body fat, BMI, and waist circumference. There were no differences between groups in fruit and vegetable intake. Extrinsic motivation decreased more in the intervention group. Conclusion The intervention produced positive changes in physical

  16. Wastes from selected activities in two light-water reactor fuel cycles

    SciTech Connect

    Palmer, C.R.; Hill, O.F.

    1980-07-01

    This report presents projected volumes and radioactivities of wastes from the production of electrical energy using light-water reactors (LWR). The projections are based upon data developed for a recent environmental impact statement in which the transuranic wastes (i.e., those wastes containing certain long-lived alpha emitters at concentrations of at least 370 becquerels, or 10 nCi, per gram of waste) from fuel cycle activities were characterized. In addition, since the WG.7 assumed that all fuel cycle wastes except mill tailings are placed in a mined geologic repository, the nontransuranic wastes from several activities are included in the projections reported. The LWR fuel cycles considered are the LWR, once-through fuel cycle (Strategy 1), in which spent fuel is packaged in metal canisters and then isolated in geologic formations; and the LWR U/Pu recycle fuel cycle (Strategy 2), wherein spent fuel is reprocessed for recovery and recycle of uranium and plutonium in LWRs. The wastes projected for the two LWR fuel cycles are summarized. The reactor operations and decommissioning were found to dominate the rate of waste generation in each cycle. These activities account for at least 85% of the fuel cycle waste volume (not including head-end wastes) when normalized to per unit electrical energy generated. At 10 years out of reactor, however, spent fuel elements in Strategy 1 represent 98% of the fuel cycle activity but only 4% of the volume. Similarly, the packaged high-level waste, fuel hulls and hardware in Strategy 2 concentrate greater than 95% of the activity in 2% of the waste volume.

  17. Microbial Enzyme Activity and Carbon Cycling in Grassland Soil Fractions

    NASA Astrophysics Data System (ADS)

    Allison, S. D.; Jastrow, J. D.

    2004-12-01

    Extracellular enzymes are necessary to degrade complex organic compounds present in soils. Using physical fractionation procedures, we tested whether old soil carbon is spatially isolated from degradative enzymes across a prairie restoration chronosequence in Illinois, USA. We found that carbon-degrading enzymes were abundant in all soil fractions, including macroaggregates, microaggregates, and the clay fraction, which contains carbon with a mean residence time of ~200 years. The activities of two cellulose-degrading enzymes and a chitin-degrading enzyme were 2-10 times greater in organic matter fractions than in bulk soil, consistent with the rapid turnover of these fractions. Polyphenol oxidase activity was 3 times greater in the clay fraction than in the bulk soil, despite very slow carbon turnover in this fraction. Changes in enzyme activity across the restoration chronosequence were small once adjusted for increases in soil carbon concentration, although polyphenol oxidase activity per unit carbon declined by 50% in native prairie versus cultivated soil. These results are consistent with a `two-pool' model of enzyme and carbon turnover in grassland soils. In light organic matter fractions, enzyme production and carbon turnover both occur rapidly. However, in mineral-dominated fractions, both enzymes and their carbon substrates are immobilized on mineral surfaces, leading to slow turnover. Soil carbon accumulation in the clay fraction and across the prairie restoration chronosequence probably reflects increasing physical isolation of enzymes and substrates on the molecular scale, rather than the micron to millimeter scale.

  18. Life Cycle of the Salmon. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Tarabochia, Kathy

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  19. Brain and behavioural evidence for rest-activity cycles in Octopus vulgaris.

    PubMed

    Brown, Euan R; Piscopo, Stefania; De Stefano, Rosanna; Giuditta, Antonio

    2006-09-25

    Octopus vulgaris maintained under a 12/12h light/dark cycle exhibit a pronounced nocturnal activity pattern. Animals deprived of rest during the light period show a marked 'rebound' in activity in the following 24h. 'Active' octopuses attack faster than 'quiet' animals and brain activity recorded electrically intensifies during 'quiet' behaviour. Thus, in Octopus as in vertebrates, brain areas involved in memory or 'higher' processes exhibit 'off-line' activity during rest periods.

  20. Do Male And Female Cyclists' Cortical Activity Differ Before and During Cycling Exercise?

    PubMed

    Ludyga, Sebastian; Gronwald, Thomas; Hottenrott, Kuno

    2015-12-01

    Although men and women are suggested to vary in resistance to fatigue, possible sex difference in its central component have rarely been investigated via electroencephalography (EEG). Therefore, we examined differences in cortical activity between male and female cyclists (n = 26) during cycling exercise. Participants performed an incremental test to derive the anaerobic threshold from the lactate power curve. In addition, cyclists' cortical activity was recorded with EEG before and during cycling exercise. Whereas women showed higher frontal alpha and beta activity at rest, no sex-specific differences of relative EEG spectral power occurred during cycling at higher intensity. Women and men's brains respond similarly during submaximal cycling, as both sexes show an inverted U-shaped curve of alpha power. Therefore, sex differences observable at rest vanish after the onset of exercise. PMID:26866769

  1. Do Male And Female Cyclists' Cortical Activity Differ Before and During Cycling Exercise?

    PubMed

    Ludyga, Sebastian; Gronwald, Thomas; Hottenrott, Kuno

    2015-12-01

    Although men and women are suggested to vary in resistance to fatigue, possible sex difference in its central component have rarely been investigated via electroencephalography (EEG). Therefore, we examined differences in cortical activity between male and female cyclists (n = 26) during cycling exercise. Participants performed an incremental test to derive the anaerobic threshold from the lactate power curve. In addition, cyclists' cortical activity was recorded with EEG before and during cycling exercise. Whereas women showed higher frontal alpha and beta activity at rest, no sex-specific differences of relative EEG spectral power occurred during cycling at higher intensity. Women and men's brains respond similarly during submaximal cycling, as both sexes show an inverted U-shaped curve of alpha power. Therefore, sex differences observable at rest vanish after the onset of exercise.

  2. Liver resection for hepatocellular carcinoma. Results of 229 consecutive patients during 11 years.

    PubMed Central

    Nagasue, N; Kohno, H; Chang, Y C; Taniura, H; Yamanoi, A; Uchida, M; Kimoto, T; Takemoto, Y; Nakamura, T; Yukaya, H

    1993-01-01

    OBJECTIVE: This study analyzed the results in 229 patients with primary hepatocellular carcinoma (HCC) who were treated by radical hepatic resection in the past 11 years. SUMMARY BACKGROUND DATA: Due to marked advances in diagnostic and therapeutic methods, the therapeutic strategy for HCC has changed significantly. However, there are still many problems to be solved when hepatic resection is to be performed for HCC associated with chronic liver disease. A satisfactory result may be possible only when all of accurate operative indication, skillful surgical technique, and sophisticated postoperative management are met. METHODS: There were 188 men and 41 women. Age ranged from 32 to 79 years averaging 60.8. Underlying cirrhosis of the liver was found in 177 patients, and chronic hepatitis was found in 47 instances. Before surgery, 114 patients had 157 associated conditions; diabetes mellitus in 66, esophageal varices in 42, cholelithiasis in 22, peptic ulcer in 12, and miscellaneous in 15 cases. In addition to various types of hepatic resection, 69 patients underwent concomitant operations such as cholecystectomy, the Warren shunt, splenectomy, partial gastrectomy, and so forth. RESULTS: The 30-day (operative) mortality rate was 7.0%, and there were eight additional late deaths (3.5%). Child's class, bromosulphalein (BSP) test, and the estimated blood loss during surgery were good predictors for operative death. The cumulative 5- and 10-year survival rates for all patients were 26.4% and 19.4%, respectively. At present, 110 patients are alive; 2 more than 10 years and 21 more than 5 years. Younger age, absence of cirrhosis, smaller tumor, and postoperative chemotherapy were associated with increased survival. CONCLUSIONS: The results of hepatic resection in 229 patients with HCC were analyzed. Child's class, BSP test, and blood loss during surgery were good predictors for operative death. The 5- and 10-year survival rates were 26.4% and 19.4%, respectively. Age

  3. Is the Valles caldera entering a new cycle of activity?

    SciTech Connect

    Wolff, J.A.; Gardner, J.N.

    1995-05-01

    The Valles caldera formed during two major rhyolitic ignimbrite eruptive episodes (the Bandelier Tuff) at 1.61 and 1.22 Ma, after some 12 m.y. of activity in the Jemez Mountains volcanic field, New Mexico. Several subsequent eruptions between 1.22 and 0.52 Ma produced dominantly high-silica rhyolite lava domes and tephras within the caldera. These were followed by a dormancy of 0.46 m.y. prior to the most recent intracaldera activity, the longest hiatus since the inception of the Bandelier magma system at approximately 1.8 Ma. The youngest volcanic activity at approximately 60 ka produced the SW moat rhyolites, a series of lavas and tuffs that display abundant petrologic evidence of being newly generated melts. Petrographic textures conform closely to published predictions for silicic magmas generated by intrusion of basaltic magma into continental crust. The Valles caldera may currently be the site of renewed silicic magma generation, induced by intrusion of mafic magma at depth. Recent seismic investigations revealed the presence of a large low-velocity anomaly in the lower crust beneath the caldera. The generally aseismic character of the caldera, despite abundant regional seismicity, may be attributed to a heated crustal column, the local effect of 13 m.y. of magmatism and emplacement of mid-crustal plutons. 24 refs., 3 figs.

  4. Cell cycle-dependent regulation of RNA polymerase II basal transcription activity.

    PubMed Central

    Yonaha, M; Chibazakura, T; Kitajima, S; Yasukochi, Y

    1995-01-01

    Regulation of transcription by RNA polymerase II (pol II) in eukaryotic cells requires both basal and regulatory transcription factors. In this report we have investigated in vitro pol II basal transcription activity during the cell cycle by using nuclear extracts from synchronized HeLa cells. It is shown that pol II basal transcription activity is low in the S and G2 phases and high in early G1 phase and TFIID is the rate limiting component of pol II basal transcription activity during the cell cycle. Further analyses reveal that TFIID exists as a less active form in the S and G2 phases and nuclear extracts from S and G2 phase cells contain a heat-sensitive repressor(s) of TATA box binding protein (TBP). These results suggest that pol II basal transcription activity is regulated by a qualitative change in the TFIID complex, which could involve repression of TBP, during the cell cycle. Images PMID:7479063

  5. Norms for the Wisconsin Card Sorting Test in 6- to 11-year-old children in Taiwan.

    PubMed

    Shu, B C; Tien, A Y; Lung, F W; Chang, Y Y

    2000-08-01

    The main aims of this study were to develop norms for the Wisconsin Card Sorting Test in 6- to 11-year-old children in Taiwan; to explore the effect of sex, age, birth order, number of siblings, and parental education on WCST performance in 6- to 11-year-old children; and to make a comparison of WCST performance between children in Taiwan and the USA. The results of this comparison of developmental norms of school children in Taiwan and the United States may facilitate the WCST as a clinical or research instrument in combination with other test procedures to assess aspects of cognitive and neuropsychological functioning of school children.

  6. Stellar magnetic cycles

    NASA Astrophysics Data System (ADS)

    Baliunas, S. L.

    2004-05-01

    Is hope for understanding the solar magnetic cycle to be found in stars? Observations of stars with significant sub-surface convective zones -- masses smaller than about 1.5 solar masses on the lower main sequence and many types of cool, post-main-sequence stars -- indicate the presence of surface and atmospheric inhomogeneities analogous to solar magnetic features, making stellar magnetic activity a cosmically widespread phenomenon. Observations have been made primarily in visible wavelengths, and important information has also been derived from the ultraviolet and x-ray spectrum regions. Interannual to interdecadal variability of spectrum indicators of stellar magnetic features is common, and in some cases similar in appearance to the 11-year sunspot cycle. Successful models of the physical processes responsible for stellar magnetic cycles, typically cast as a magnetohydrodynamic dynamo, require advances in understanding not only convection but also the magnetic field's interaction with it. The observed facts that underpin the hope for models will be summarized. Properties of stellar magnetic cycles will be compared and contrasted with those of the sun, including inferences from paleo-environmental reservoirs that contain information on solar century- to millennial-scale magnetic variability. Partial support of this research came from NASA NAG5-7635, NRC COBASE, CRDF 322, MIT-MSG 5710001241, JPL 1236821, AF 49620-02-1-0194, Richard Lounsberry Foundation, Langley-Abbot, Rollins, Scholarly Studies and James Arthur Funds (Smithsonian Institution) and several generous individuals.

  7. Active vibration and balance system for closed cycle thermodynamic machines

    NASA Technical Reports Server (NTRS)

    Qiu, Songgang (Inventor); Augenblick, John E. (Inventor); Peterson, Allen A. (Inventor); White, Maurice A. (Inventor)

    2004-01-01

    An active balance system is provided for counterbalancing vibrations of an axially reciprocating machine. The balance system includes a support member, a flexure assembly, a counterbalance mass, and a linear motor or an actuator. The support member is configured for attachment to the machine. The flexure assembly includes at least one flat spring having connections along a central portion and an outer peripheral portion. One of the central portion and the outer peripheral portion is fixedly mounted to the support member. The counterbalance mass is fixedly carried by the flexure assembly along another of the central portion and the outer peripheral portion. The linear motor has one of a stator and a mover fixedly mounted to the support member and another of the stator and the mover fixedly mounted to the counterbalance mass. The linear motor is operative to axially reciprocate the counterbalance mass. A method is also provided.

  8. OECD/NEA Ongoing activities related to the nuclear fuel cycle

    SciTech Connect

    Cornet, S.M.; McCarthy, K.; Chauvin, N.

    2013-07-01

    As part of its role in encouraging international collaboration, the OECD Nuclear Energy Agency is coordinating a series of projects related to the Nuclear Fuel Cycle. The Nuclear Science Committee (NSC) Working Party on Scientific Issues of the Nuclear Fuel Cycle (WPFC) comprises five different expert groups covering all aspects of the fuel cycle from front to back-end. Activities related to fuels, materials, physics, separation chemistry, and fuel cycles scenarios are being undertaken. By publishing state-of-the-art reports and organizing workshops, the groups are able to disseminate recent research advancements to the international community. Current activities mainly focus on advanced nuclear systems, and experts are working on analyzing results and establishing challenges associated to the adoption of new materials and fuels. By comparing different codes, the Expert Group on Advanced Fuel Cycle Scenarios is aiming at gaining further understanding of the scientific issues and specific national needs associated with the implementation of advanced fuel cycles. At the back end of the fuel cycle, separation technologies (aqueous and pyrochemical processing) are being assessed. Current and future activities comprise studies on minor actinides separation and post Fukushima studies. Regular workshops are also organized to discuss recent developments on Partitioning and Transmutation. In addition, the Nuclear Development Committee (NDC) focuses on the analysis of the economics of nuclear power across the fuel cycle in the context of changes of electricity markets, social acceptance and technological advances and assesses the availability of the nuclear fuel and infrastructure required for the deployment of existing and future nuclear power. The Expert Group on the Economics of the Back End of the Nuclear Fuel Cycle (EBENFC), in particular, is looking at assessing economic and financial issues related to the long term management of spent nuclear fuel. (authors)

  9. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

    SciTech Connect

    Ding, Li; Huang, Yong; Du, Qian; Dong, Feng; Zhao, Xiaomin; Zhang, Wenlong; Xu, Xingang; Tong, Dewen

    2014-03-07

    Highlights: • TGEV N protein reduces cell viability by inducing cell cycle arrest and apoptosis. • TGEV N protein induces cell cycle arrest and apoptosis by regulating p53 signaling. • TGEV N protein plays important roles in TGEV-induced cell cycle arrest and apoptosis. - Abstract: Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.

  10. The phase shift between the hemispheres in the solar activity cycle

    NASA Astrophysics Data System (ADS)

    Shibalova, A. S.; Obridko, V. N.; Sokoloff, D. D.

    2016-10-01

    The shift between the solar activity cycles in the northern and southern hemispheres of the Sun is studied using data on sunspot number and area. The data obtained are compared with archival information on episodes of appreciable solar-cycle asymmetry. The small phase shift between recent activity cycles in the northern and southern solar hemispheres differs considerably from the shift for episodes of appreciable deviations from dipolar symmetry in the sunspot distribution detected with various degrees of confidence in archival astronomical data from the 17th-19th centuries. The current time shift between the hemispheres is insignificant, about 6-7 months. This shift has changed its sign twice in recent solar history; this probably corresponds to more or less periodic variations with a timescale close to the duration of the Gleissberg cycle.

  11. Finding year-long activity cycles in ground-based and space-borne photometry

    NASA Astrophysics Data System (ADS)

    Vida, Krisztián; Oláh, Katalin; Szabó, Róbert

    2015-08-01

    Using long­term ground­based photometry of fast­rotating M­-dwarfs (EY Dra, V405 And, GSC 3377­0296 and V374 Peg), all with rotational periods near 0.5 day, but with different internal structures, we found activity cycles in the form of long-­term brightness changes, on the time scales of about one year. Using the cycling stars as templates, we searched for similar, fast rotating (P < 1d), active, late­-type targets in the Kepler Input Catalogue. Analysing the light curves of these 39 stars, we found hints of 300­-900 day­-long cycles in 9 cases detecting small variations in the rotation periods caused by differential rotation and the changing spot emergence latitudes over the cycle (i.e., the butterfly diagram).

  12. Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.

    PubMed

    Kong, Dong; Farmer, Veronica; Shukla, Anil; James, Jana; Gruskin, Richard; Kiriyama, Shigeo; Loncarek, Jadranka

    2014-09-29

    Newly formed centrioles in cycling cells undergo a maturation process that is almost two cell cycles long before they become competent to function as microtubule-organizing centers and basal bodies. As a result, each cell contains three generations of centrioles, only one of which is able to form cilia. It is not known how this long and complex process is regulated. We show that controlled Plk1 activity is required for gradual biochemical and structural maturation of the centrioles and timely appendage assembly. Inhibition of Plk1 impeded accumulation of appendage proteins and appendage formation. Unscheduled Plk1 activity, either in cycling or interphase-arrested cells, accelerated centriole maturation and appendage and cilia formation on the nascent centrioles, erasing the age difference between centrioles in one cell. These findings provide a new understanding of how the centriole cycle is regulated and how proper cilia and centrosome numbers are maintained in the cells.

  13. The solar cycle variation of the rates of CMEs and related activity

    NASA Technical Reports Server (NTRS)

    Webb, David F.

    1991-01-01

    Coronal mass ejections (CMEs) are an important aspect of the physics of the corona and heliosphere. This paper presents results of a study of occurrence frequencies of CMEs and related activity tracers over more than a complete solar activity cycle. To properly estimate occurrence rates, observed CME rates must be corrected for instrument duty cycles, detection efficiencies away from the skyplane, mass detection thresholds, and geometrical considerations. These corrections are evaluated using CME data from 1976-1989 obtained with the Skylab, SMM and SOLWIND coronagraphs and the Helios-2 photometers. The major results are: (1) the occurrence rate of CMEs tends to track the activity cycle in both amplitude and phase; (2) the corrected rates from different instruments are reasonably consistent; and (3) over the long term, no one class of solar activity tracer is better correlated with CME rate than any other (with the possible exception of type II bursts).

  14. Relationships between solar activity and climate change. [sunspot cycle effects on lower atmosphere

    NASA Technical Reports Server (NTRS)

    Roberts, W. O.

    1974-01-01

    Recurrent droughts are related to the double sunspot cycle. It is suggested that high solar activity generally increases meridional circulations and blocking patterns at high and intermediate latitudes, especially in winter. This effect is related to the sudden formation of cirrus clouds during strong geomagnetic activity that originates in the solar corpuscular emission.

  15. Relationship between skin temperature and muscle activation during incremental cycle exercise.

    PubMed

    Priego Quesada, Jose I; Carpes, Felipe P; Bini, Rodrigo R; Salvador Palmer, Rosario; Pérez-Soriano, Pedro; Cibrián Ortiz de Anda, Rosa M

    2015-02-01

    While different studies showed that better fitness level adds to the efficiency of the thermoregulatory system, the relationship between muscular effort and skin temperature is still unknown. Therefore, the present study assessed the relationship between neuromuscular activation and skin temperature during cycle exercise. Ten physically active participants performed an incremental workload cycling test to exhaustion while neuromuscular activations were recorded (via surface electromyography - EMG) from rectus femoris, vastus lateralis, biceps femoris and gastrocnemius medialis. Thermographic images were recorded before, immediately after and 10 min after finishing the cycling test, at four body regions of interest corresponding to the muscles where neuromuscular activations were monitored. Frequency band analysis was conducted to assess spectral properties of EMG signals in order to infer on priority in recruitment of motor units. Significant inverse relationship between changes in skin temperature and changes in overall neuromuscular activation for vastus lateralis was observed (r<-0.5 and p<0.04). Significant positive relationship was observed between skin temperature and low frequency components of neuromuscular activation from vastus lateralis (r>0.7 and p<0.01). Participants with larger overall activation and reduced low frequency component for vastus lateralis activation presented a better adaptive response of their thermoregulatory system by showing fewer changes in skin temperature after incremental cycling test.

  16. Body temperature and physical activity correlates of the menstrual cycle in Chacma Baboons (Papio hamadryas ursinus).

    PubMed

    Nyakudya, Trevor T; Fuller, Andrea; Meyer, Leith C R; Maloney, Shane K; Mitchell, Duncan

    2012-12-01

    We investigated the temporal relationship between abdominal temperature, physical activity, perineal swelling, and urinary progesterone and estradiol concentrations over the menstrual cycle in unrestrained captive baboons. Using a miniature temperature-sensitive data logger surgically implanted in the abdominal cavity and an activity data logger implanted subcutaneously on the trunk, we measured, continuously over 6 months at 10-min intervals, abdominal temperature and physical activity patterns in four female adult baboons Papio hamadryas ursinus (12.9-19.9 kg), in cages in an indoor animal facility (22-25°C). We monitored menstrual bleeding and perineal swelling changes, and measured urinary progesterone and estradiol concentrations, daily for up to 6 months, to ascertain the stage and length of the menstrual cycle. The menstrual cycle was 36 ± 2 days (mean ± SD) long and the baboons exhibited cyclic changes in perineal swellings, abdominal temperature, physical activity, urinary progesterone, and estradiol concentrations over the cycle. Mean 24-hr abdominal temperature during the luteal phase was significantly higher than during the periovulatory phase (ANOVA, F((2, 9)) = 4.7; P = 0.04), but not different to that during the proliferative phase. Physical activity followed a similar pattern, with mean 24-hr physical activity almost twice as high in the luteal than in the periovulatory phase (ANOVA, P = 0.58; F((2, 12)) = 5.8). We have characterized correlates of the menstrual cycle in baboons and shown, for the first time, a rhythm of physical activity and abdominal temperature over the menstrual cycle, with a nadir of temperature and activity at ovulation.

  17. Effect of Ball Mass on Dribble, Pass, and Pass Reception in 9-11-Year-Old Boys' Basketball

    ERIC Educational Resources Information Center

    Arias, Jose L.; Argudo, Francisco M.; Alonso, Jose I.

    2012-01-01

    The objective of the study was to analyze the effect of ball mass on dribble, pass, and pass reception in real game situations in 9-11-year-old boys' basketball. Participants were 54 boys identified from six federated teams. The independent variable was ball mass, and dependent variables were number of dribbles, passes, and pass receptions. Three…

  18. Expectations and Levels of Understanding When Using Mobile Phones among 9-11-Year Olds in Wales, UK

    ERIC Educational Resources Information Center

    Turley, Joanne; Baker, Sally-Ann; Lewis, Christopher Alan

    2014-01-01

    There is growing interest in examining the use of mobile technology among children. The present study extended this literature among a sample of 9-11-year olds in Wales, UK in three ways. First, to examine the level of mobile phone ownership; second, to consider how mobile phones are used, investigate timescales and expectations when communicating…

  19. Maximal Voluntary Static Force Production Characteristics of Skeletal Muscle in Children 8-11 Years of Age.

    ERIC Educational Resources Information Center

    Going, Scott B.; And Others

    1987-01-01

    A study of maximal voluntary isometric muscle contraction force-time curves among 32 normal, healthy 8- to 11-year-olds performing tasks involving separate muscle groups found that force and maximal rate of force increase were quite reproducible, but time to selected force levels reflected considerable variations. (Author/CB)

  20. Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children

    ERIC Educational Resources Information Center

    Devine, Paula; Lloyd, Katrina

    2012-01-01

    This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

  1. Chiari type 1 malformation, corpus callosum agenesis and patent craniopharyngeal canal in an 11-year-old boy.

    PubMed

    Tijssen, Maud Pm; Poretti, Andrea; Huisman, Thierry Agm

    2016-10-01

    We describe the neuroimaging findings of an 11-year-old boy who presented with mild occipital headache and precocious puberty. This child was found to have a combination of various midline anomalies including a Chiari type 1 malformation, corpus callosum agenesis and patent craniopharyngeal canal with adjacent intracranial dermoid cyst.

  2. Capturing the Cumulative Effects of School Reform: An 11-Year Study of the Impacts of America's Choice on Student Achievement

    ERIC Educational Resources Information Center

    May, Henry; Supovitz, Jonathan A.

    2006-01-01

    This article presents the results of an 11-year longitudinal study of the impact of America's Choice comprehensive school reform (CSR) design on student learning gains in Rochester, New York. A quasi-experimental interrupted time-series approach using Bayesian hierarchical growth curve analysis with crossed random effects is used to compare the…

  3. Comparative Analysis of Musical Abilities of 11-Year-Olds from Slovenia and the Island of Martinique

    ERIC Educational Resources Information Center

    Jerman, Janez; Pretnar, Tatjana

    2006-01-01

    The focus of the study is the comparison between the musical abilities of 11-year-old children on the island of Martinique and in Slovenia, and finding out to what extent their development of musical abilities is influenced by musical and cultural family background, music school attendance, choral singing and playing orchestral instruments. Our…

  4. Surface electromyographic activities of upper body muscles during high-intensity cycle ergometry.

    PubMed

    McCormick, Marie Clare; Watson, Hugh; Simpson, Alan; Kilgore, Lon; Baker, Julien S

    2014-01-01

    The aim of this study was to investigate upper body muscle activity during a 30 s Wingate test. Eighteen physically active participants performed a Wingate test while muscle activity was recorded from the brachioradialis (BR), biceps brachii (BB), triceps brachii (TB) and upper trapezius (UT). Measurements were obtained at rest, during a function maximal contraction (FMC) and during the 30 s Wingate test, whilst participants were positioned in a seated position on the cycle ergometer. All muscles were significantly active for the duration of the test. When normalized as a %FMC no differences in activity were found between muscles. Across the 30 s, power output was found to significantly decrease, whereas no changes were found in upper body muscle activity. All muscles investigated were active during the Wingate test and therefore confirmed previous findings that the upper body significantly contributes to power profiles obtained during high intensity cycle ergometry in addition to its role in stabilizing the body.

  5. Tubulin dynamics during the cytoplasmic cohesiveness cycle in artificially activated sea urchin eggs.

    PubMed

    Coffe, G; Foucault, G; Raymond, M N; Pudles, J

    1983-12-01

    Sedimentation studies and [3H]colchicine-binding assays have demonstrated a relationship between the cytoplasmic cohesiveness cycles and the changes in tubulin organization in Paracentrotus lividus eggs activated by 2.5 mM procaine. The same amount of tubulin (20-25% of the total egg tubulin) is involved in these cyclic process and appears to undergo polymerization and depolymerization cycles. Electron microscopy studies reveal that the microtubules formed during these cytoplasmic cohesiveness cycles are under a particulate form which is sedimentable at low speed. Activation experiments carried out in the presence of cytochalasin B (CB) show that the increase in the cytoplasmic cohesiveness is highly reduced while tubulin polymerization and depolymerization cycles and pronuclear centration are not affected. Although tubulin or actin polymerization can be independently triggered in procaine-activated eggs, the increase in cytoplasmic cohesiveness requires the polymerization of both proteins. However, the cytoplasmic cohesiveness cycles appear to be regulated by tubulin polymerization and depolymerization cycles. PMID:6641809

  6. The sperm donor programme over 11 years at Newcastle Fertility Centre.

    PubMed

    Gudipati, Madhavi; Pearce, Kim; Prakash, Alka; Redhead, Gillian; Hemingway, Victoria; McEleny, Kevin; Stewart, Jane

    2013-12-01

    The UK national sperm donor shortage is well known. We aimed to analyse the trends in various aspects of the sperm donor programme at Newcastle Fertility Centre (NFC) between 2000 and 2010. A retrospective review of the assisted conception treatments with donor sperm was performed. A decline in the numbers of donors recruited alongside a declining trend in the number of patients treated with donor sperm and donor insemination (DI) treatment cycles carried out was apparent. There was an accompanying rising trend in donor IVF cycles and in same-sex couples and single women coming for treatment. The transfer of sperm to local peripheral centres ceased during this time and an increasing number of patients imported sperm from overseas commercial sperm banks. A waiting list for treatment was set up in 2007 with a gradual increase in waiting time to 18 months in 2010. Overall, there was a significant change in the sperm donor programme at NFC with fewer donors recruited, fewer patients receiving treatment, increasing sperm import and longer waiting times for treatment over the study period.

  7. Effects of aluminum on activity of krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate.

    PubMed

    Zatta, P; Lain, E; Cagnolini, C

    2000-05-01

    Aluminum is a neurotoxic agent for animals and humans that has been implicated as an etiological factor in several neurodegenerative diseases and as a destabilizer of cell membranes. Due to its high reactivity, Al3+ is able to interfere with several biological functions, including enzymatic activities in key metabolic pathways. In this paper we report that, among the enzymes that constitute the Krebs cycle, only two are activated by aluminum: alpha-ketoglutarate dehydrogenase and succinate dehydrogenase. In contrast, aconitase, shows decreased activity in the presence of the metal ion. Al3+ also inhibits glutamate dehydrogenase, an allosteric enzyme that is closely linked to the Krebs cycle. A possible correlation between aluminum, the Krebs cycle and aging processes is discussed.

  8. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle

    PubMed Central

    Protopopescu, Xenia; Pan, Hong; Altemus, Margaret; Tuescher, Oliver; Polanecsky, Margaret; McEwen, Bruce; Silbersweig, David; Stern, Emily

    2005-01-01

    The orbitofrontal cortex (OFC) has been implicated in the representation of emotional stimuli, assignment of emotional valence/salience to stimuli, stimulus-reinforcement association learning, motivation, and socio-emotional control. Using functional magnetic resonance imaging in female subjects without premenstrual mood symptoms, we found that OFC activity to emotional linguistic stimuli varies depending on the menstrual cycle phase. Specifically, anterior-medial OFC activity for negative vs. neutral stimuli was increased premenstrually and decreased postmenstrually. The inverse pattern was seen in the lateral OFC. These findings suggest that specific subregional OFC activity to emotional stimuli is modulated across the menstrual cycle. The data also demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation. PMID:16247013

  9. Sex-dependent activity of the spinal excitatory amino acid transporter: Role of estrous cycle.

    PubMed

    Sajjad, Jahangir; Felice, Valeria D; Golubeva, Anna V; Cryan, John F; O'Mahony, Siobhain M

    2016-10-01

    Females are more likely to experience visceral pain than males, yet mechanisms underlying this sex bias are not fully elucidated. Moreover, pain sensitivity can change throughout the menstrual cycle. Alterations in the glutamatergic system have been implicated in several pain-disorders; however, whether these are sex-dependent is unclear. Thus, we aimed to investigate sex differences in the spinal cord glutamate uptake and how it varies across the estrous cycle. The activity of the glutamate transporters, excitatory amino acid transporters (EAATs) was assessed using an ex vivo aspartate radioactive uptake assay in the lumbosacral spinal cord in Sprague-Dawley male and female rats. The gene expression of EAATs, glutamate receptor subunits NR1 and NR2B and the estrogen receptors ERα & ERβ in the spinal cord were also analyzed. EAAT activity was lower in females, particularly during the estrus phase, and this was the only cycle stage that was responsive to the pharmacological effects of the EAATs activator riluzole. Interestingly, EAAT1 mRNA expression was lower in high-estrogen and high-ERα states compared to diestrus in females. We conclude that the Spinal EAAT activity in females is different to that in males, and varies across the estrous cycle. Furthermore, the expression levels of estrogen receptors also showed a cycle-dependent pattern that may affect EAATs function and expression. PMID:27471194

  10. Low-intensity cycling affects the muscle activation pattern of consequent countermovement jumps.

    PubMed

    Marquez, Gonzalo J; Mon, Javier; Acero, Rafael M; Sanchez, Jose A; Fernandez-del-Olmo, Miguel

    2009-08-01

    Players (eg, basketball, soccer, and football) often use a static bicycle during a game to maintain warming. However, the effectiveness of this procedure has not been addressed in the literature. Thus, it remains unknown whether low-intensity cycling movement can affect explosive movement performance. In this study, 10 male subjects performed countermovement jumps before and after a 15-minutes cycling bout at 35% of their maximal power output. Three sessions were tested for 3 different cadences of cycling: freely chosen cadence, 20% lower than freely chosen cadence (FCC-20%), and 20% higher than freely chosen cadence (FCC+20%). Jump height, kinematics, and electromyogram were recorded simultaneously during the countermovement jumps. The results showed a significant decreasing in the height of countermovement jump after cycling at freely chosen cadence and FCC-20% (p = 0.03 and p = 0.04, respectively), but not for FCC+20% cadences. The electromyographic parameters suggest that changes in the countermovement jump after cycling can be attributed to alteration of the pattern of activation and may be modulated by the preceding cycling cadence. Our study indicates that to avoid a possible negative effect of the cycling in the subsequent explosive movements, a cadence 20% higher than the preferred cadence must be used.

  11. A New Component of Solar Dynamics: North-South Diverging Flows Migrating toward the Equator with an 11 Year Period

    NASA Technical Reports Server (NTRS)

    Beck, J. G.; Gizon, L.; Duvall, Thomas L., Jr.; Oegerle, William R. (Technical Monitor)

    2002-01-01

    Time-distance helioseismology analysis of dopplergrams provides maps of torsional oscillations and meridional flows. Meridional flow maps show a time-varying component that has a banded structure which matches the torsional oscillations with an equatorward migration over the solar cycle. The time-varying component of meridional flow consists of a flow diverging from the dominant latitude of magnetic activity. These maps are compared with other torsional oscillation maps and with magnetic flux maps, showing a strong correlation with active latitudes. These results demonstrate a strong link between the time-varying component of the meridional flow and the torsional oscillations.

  12. Effects of physical activity on pupil cycle time (PCT) in healthy Indian male.

    PubMed

    Ghosh, Suparna; Avadhany, Sandhya T

    2014-01-01

    Globally, physical inactivity is an important risk factor for the development of non-communicable disease consisting of coronary artery disease, as well as, other diseases including hypertension, diabetes, obesity, osteoporosis, and certain types of cancers. Parasympathetic nervous system (PNS) activity in the eye is determined by the pupil cycle time (PCT) can be comparable with cardiac parasympathetic response and thereby determine the morbidity and mortality among individuals. The PCT is measured by throwing white light on the edge of the pupil. Pupil cycling is a feature of pupillary reflex arc. The aim of this study is to establish the effect of physical activity on the PCT. The counting of PCT was done for 90 cycles and average one count is considered a single PCT. The physical activity level (PAL) was determined by administering a physical activity level questionnaire developed in the Division of Nutrition, St. John's Medical College, Bangalore. The PAL is classified as < 1.4 as sedentary, 1.55 to 1.75 moderately active, and > 1.75 heavily active. Thirty healthy male volunteers in the age group of 18-50 years and with BMI of 18.5 kg/m2-30 kg/m2 were studied. We obtained PCT of 962.00 ± 105.72 msec in sedentary, 896.77 ± 85.88 msec in moderately active and 889.45 ± 68.71 msec in heavily active individuals. Linear regression analysis shows there is statistically significant difference between the three different groups of physical activity level with a b value of 0 and R2 being 0.19. Increase in physical activity led to decrease in the PCT i.e. increase in the parasympathetic tone in the eye. Pupil cycle time (PCT) is a simple noninvasive tool to assess and differentiate the PNS function in different activity level of individual. PMID:25906609

  13. Statistical properties of Hα flares in relation to sunspots and active regions in the cycle 23

    NASA Astrophysics Data System (ADS)

    Zharkov, S. I.; Zharkova, V. V.

    2011-02-01

    The statistical properties of Hα flare occurrences compared with those of sunspot and active region areas in the cycle 23. The flare numbers in the cycle 23 of all significances and locations were obtained from the Solar Geophysical Data (SGD) and the other data were taken from the automated Solar Feature Catalogues (SFC, http://solar.inf.brad.ac.uk). The average monthly flare occurrences during the whole cycle correlate closely with the total and cumulative areas of active regions and sunspots. The cumulative distribution of solar flare occurrences at different latitudes in the northern and southern hemispheres versus the time reveal a strong asymmetry with a domination of one or other hemispheres similar to the cumulative distributions of sunspots and active regions. Although the sunspot area asymmetry lags the flare occurrence asymmetry by about a few months at the ascending phase of the cycle and up to 12 months in the descending one. The latitudinal distribution of flare occurrences in the whole period reveals a well defined maximum at 18∘ in the northern and two maxima at 14∘ and 20∘ in the southern hemisphere. The longitudinal distributions of flare occurrence residuals of the running values and those averaged with a one year filter reveal a set of persistent longitudes in the opposite hemispheres lasting for about 1.0-1.5 years and changing quickly a few times over the cycle phases.

  14. [The development of the activity-rest cycle in the rabbit fetus].

    PubMed

    Belich, A I; Nazarova, L A

    1988-01-01

    On 25-30-day rabbit foetuses, in chronic experiments using constant synchronous recording of the motor activity and heart rate, studies have been made of temporal organization of the activity-rest cycle. Already in 25-day foetus, three functional conditions may be distinguished: active, intermediate and resting ones, the duration of the latter increasing to the end of gestation up to 8-10 min, whereas the duration of the intermediate phase decreases, reaching its minimum to the 30th day if not being completely reduced. Cyclic pattern of active and resting phases is observed in 28-day foetuses; to the 29th-30th day, these phases from a unique activity-rest cycle, its duration reaching 20-30 min to the end of intrauterine period. It is suggested that the resting phase in foetal rabbits serves as a basis for the development of polyphasic sleep in adult animals. PMID:3414220

  15. Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome

    PubMed Central

    Stickford, Abigail SL; VanGundy, Tiffany B; Levine, Benjamin D; Fu, Qi

    2015-01-01

    Abstract Patients with the postural orthostatic tachycardia syndrome (POTS) are primarily premenopausal women, which may be attributed to female sex hormones. We tested the hypothesis that hormonal fluctuations of the menstrual cycle alter sympathetic neural activity and orthostatic tolerance in POTS women. Ten POTS women were studied during the early follicular (EF) and mid-luteal (ML) phases of the menstrual cycle. Haemodynamics and muscle sympathetic nerve activity (MSNA) were measured when supine, during 60 deg upright tilt for 45 min or until presyncope, and during the cold pressor test (CPT) and Valsalva manoeuvres. Blood pressure and total peripheral resistance were higher during rest and tilting in the ML than EF phase; however, heart rate, stroke volume and cardiac output were similar between phases. There were no mean ± SD differences in MSNA burst frequency (8 ± 8 EF phase vs. 10 ± 10 bursts min–1 ML phase at rest; 34 ± 15 EF phase vs. 36 ± 16 bursts min–1 ML phase at 5 min tilt), burst incidence or total activity, nor any differences in the cardiovagal and sympathetic baroreflex sensitivities between phases under any condition. The incidence of presyncope was also the same between phases. There were no differences in haemodynamic or sympathetic responses to CPT or Valsalva. These results suggest that the menstrual cycle does not affect sympathetic neural activity but modulates blood pressure and vasoconstriction in POTS women during tilting. Thus, factors other than sympathetic neural activity are probably responsible for the symptoms of orthostatic intolerance across the menstrual cycle in women with POTS. Key points Women with the postural orthostatic tachycardia syndrome (POTS) report fluctuations in orthostatic tolerance throughout the menstrual cycle. The mechanism(s) underlying blood pressure control across the menstrual cycle in women with POTS are unknown. The findings of the present study indicate that the menstrual

  16. Solar Magnetic Activity Cycles, Coronal Potential Field Models and Eruption Rates

    NASA Astrophysics Data System (ADS)

    Petrie, G. J. D.

    2013-05-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the National Solar Observatory's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun vector spectro-magnetograph, the spectro-magnetograph and the 512-channel magnetograph instruments, and from Stanford University's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Polar field changes are found to be well correlated with active fields over most of the period studied, except between 2003 and 2006 when the active fields did not produce significant polar field changes. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The tilt of the solar dipole is therefore almost entirely due to active-region fields. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking, Solar Eruptive Event Detection System, and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003 and 2012 than for those between 1997 and 2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  17. SOLAR MAGNETIC ACTIVITY CYCLES, CORONAL POTENTIAL FIELD MODELS AND ERUPTION RATES

    SciTech Connect

    Petrie, G. J. D.

    2013-05-10

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the National Solar Observatory's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun vector spectro-magnetograph, the spectro-magnetograph and the 512-channel magnetograph instruments, and from Stanford University's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Polar field changes are found to be well correlated with active fields over most of the period studied, except between 2003 and 2006 when the active fields did not produce significant polar field changes. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The tilt of the solar dipole is therefore almost entirely due to active-region fields. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking, Solar Eruptive Event Detection System, and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003 and 2012 than for those between 1997 and 2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  18. Skinfold thickness at ulnar, triceps, subscapular, and suprailiac regions in 1,656 Japanese children aged 3-11 years.

    PubMed

    Ohzeki, T; Hanaki, K; Motozumi, H; Matsuda-Ohtahara, H; Shiraki, K

    1992-01-01

    We measured body weight, height, and skinfold thickness (SFT) at ulnar, triceps, subscapular and suprailiac regions in 1,656 Japanese children aged 3-11 years. Means of SFT in boys and girls with normal weight exhibited similar changes with age to Caucasian children. However, nadirs of SFT were observed 1 year earlier and means at 11 years were slightly higher in Japanese. Correlation coefficients between SFT and excess weight (EW) were high in boys and girls when EW was more than 10%. Some children with EW of more than 10% had abnormal SFT. Skinfolds in all children with EW of 30% or more were beyond the normal limits. In this study, normal ranges of SFT in Japanese children are demonstrated and their racial characteristics are compared to Caucasians. It is suggested that children with EW of 10-30% are heterogenous and determination of fat volume is essential to confirm the diagnosis of obesity in these subjects.

  19. Blue Sky Below My Feet: Daycamp & After School Programs--9 to 11 Year Olds. Leader's Manual.

    ERIC Educational Resources Information Center

    California Univ., Berkeley. Cooperative Extension Service.

    This manual presents a 10-day lesson plan for day camp and after-school program leaders. The activities and experiments described in the manual focus on nutrition and space exploration. Topics covered by the lesson plan and specific projects include: (1) gravity; (2) food spoilage; (3) model rocket building and launching; (4) the basic food…

  20. Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle.

    PubMed

    Albert, Kimberly; Pruessner, Jens; Newhouse, Paul

    2015-09-01

    Although ovarian hormones are thought to have a potential role in the well-known sex difference in mood and anxiety disorders, the mechanisms through which ovarian hormone changes contribute to stress regulation are not well understood. One mechanism by which ovarian hormones might impact mood regulation is by mediating the effect of psychosocial stress, which often precedes depressive episodes and may have mood consequences that are particularly relevant in women. In the current study, brain activity and mood response to psychosocial stress was examined in healthy, normally cycling women at either the high or low estradiol phase of the menstrual cycle. Twenty eight women were exposed to the Montreal Imaging Stress Task (MIST), with brain activity determined through functional magnetic resonance imaging, and behavioral response assessed with subjective mood and stress measures. Brain activity responses to psychosocial stress differed between women in the low versus high estrogen phase of the menstrual cycle: women with high estradiol levels showed significantly less deactivation in limbic regions during psychosocial stress compared to women with low estradiol levels. Additionally, women with higher estradiol levels also had less subjective distress in response to the MIST than women with lower estradiol levels. The results of this study suggest that, in normally cycling premenopausal women, high estradiol levels attenuate the brain activation changes and negative mood response to psychosocial stress. Normal ovarian hormone fluctuations may alter the impact of psychosocially stressful events by presenting periods of increased vulnerability to psychosocial stress during low estradiol phases of the menstrual cycle. This menstrual cycle-related fluctuation in stress vulnerability may be relevant to the greater risk for affective disorder or post-traumatic stress disorder in women.

  1. Speech-Language and swallowing manifestations and rehabilitation in an 11-year-old girl with MELAS syndrome.

    PubMed

    Vandana, V P; Bindu, Parayil Sankaran; Sonam, Kothari; Taly, Arun B; Gayathri, N; Madhu, N; Sinha, S

    2015-01-01

    Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare mitochondrial disease. The available studies on MELAS syndrome are limited to evaluation of radiological, audiological, genetic, and neurological findings. Among the various neurological manifestations, speech-language and swallowing manifestations are less discussed in the literature. This report describes the speech-language and swallowing function in an 11-year-old girl with MELAS syndrome. The intervention over a period of 6 months is discussed.

  2. Changes in element contents of four lichens over 11 years in the Boundary Waters Canoe Area Wilderness, northern Minnesota

    USGS Publications Warehouse

    Bennett, J.P.; Wetmore, C.M.

    1999-01-01

    Four species of lichen (Cladina rangiferina, Evernia mesomorpha, Hypogymnia physodes, and Parmelia sulcata) were sampled at six locations in the Boundary Waters Canoe Area Wilderness three times over a span of 11 years and analyzed for concentrations of 16 chemical elements to test the hypotheses that corticolous species would accumulate higher amounts of chemical elements than terricolous species, and that 11 years were sufficient to detect spatial patterns and temporal trends in element contents. Multivariate analyses of over 2770 data points revealed two principal components that accounted for 68% of the total variance in the data. These two components, the first highly loaded with Al, B, Cr, Fe, Ni and S, and the second loaded with Ca, Cd, Mg and Mn, were inversely related to each other over time and space. The first component was interpreted as consisting of an anthropogenic and a dust component, while the second, primarily a nutritional component. Cu, K, Na, P, Pb and Zn were not highly loaded on either component. Component 1 decreased significantly over the 11 years and from west to east, while component 2 increased. The corticolous species were more enriched in heavy metals than the terricolous species. All four elements in component 2 in H. physodes were above enrichment thresholds for this species. Species differences on the two components were greater than the effects of time and space, suggesting that biomonitoring with lichens is strongly species dependent. Some localities in the Boundary Waters Canoe Area Wilderness appear enriched in some anthropogenic elements for no obvious reasons.

  3. US Activities in Making Life Cycle Inventory Data More Available to Users

    EPA Science Inventory

    The demand for LCA studies continues to grow, although, the lack of reliable, transparent Life Cycle Inventory (LCI) data is hampering the wide-spread application of LCA. This paper will present activities related to the development and accessibility of process LCI data in the U...

  4. The Development of a New Practical Activity: Using Microorganisms to Model Gas Cycling

    ERIC Educational Resources Information Center

    Redfern, James; Burdass, Dariel; Verran, Joanna

    2014-01-01

    For many in the school science classroom, the term "microbiology" has become synonymous with "bacteriology". By overlooking other microbes, teachers may miss out on powerful practical tools. This article describes the development of an activity that uses algae and yeast to demonstrate gas cycling, and presents full instructions…

  5. Solar activity cycle and the incidence of foetal chromosome abnormalities detected at prenatal diagnosis

    NASA Astrophysics Data System (ADS)

    Halpern, Gabrielle J.; Stoupel, Eliahu G.; Barkai, Gad; Chaki, Rina; Legum, Cyril; Fejgin, Moshe D.; Shohat, Mordechai

    1995-06-01

    We studied 2001 foetuses during the period of minimal solar activity of solar cycle 21 and 2265 foetuses during the period of maximal solar activity of solar cycle 22, in all women aged 37 years and over who underwent free prenatal diagnosis in four hospitals in the greater Tel Aviv area. There were no significant differences in the total incidence of chromosomal abnormalities or of trisomy between the two periods (2.15% and 1.8% versus 2.34% and 2.12%, respectively). However, the trend of excessive incidence of chromosomal abnormalities in the period of maximal solar activity suggests that a prospective study in a large population would be required to rule out any possible effect of extreme solar activity.

  6. Actors of the main activity in large complex centres during the 23 solar cycle maximum

    NASA Astrophysics Data System (ADS)

    Schmieder, B.; Démoulin, P.; Pariat, E.; Török, T.; Molodij, G.; Mandrini, C. H.; Dasso, S.; Chandra, R.; Uddin, W.; Kumar, P.; Manoharan, P. K.; Venkatakrishnan, P.; Srivastava, N.

    2011-06-01

    During the maximum of Solar Cycle 23, large active regions had a long life, spanning several solar rotations, and produced large numbers of X-class flares and CMEs, some of them associated to magnetic clouds (MCs). This is the case for the Halloween active regions in 2003. The most geoeffective MC of the cycle (Dst = -457) had its source during the disk passage of one of these active regions (NOAA 10501) on 18 November 2003. Such an activity was presumably due to continuous emerging magnetic flux that was observed during this passage. Moreover, the region exhibited a complex topology with multiple domains of different magnetic helicities. The complexity was observed to reach such unprecedented levels that a detailed multi-wavelength analysis is necessary to precisely identify the solar sources of CMEs and MCs. Magnetic clouds are identified using in situ measurements and interplanetary scintillation (IPS) data. Results from these two different sets of data are also compared.

  7. Climatic variables as indicators of solar activity

    NASA Astrophysics Data System (ADS)

    Balybina, A. S.; Karakhanyan, A. A.

    2012-12-01

    Tree-ring analysis is used successfully in studies of solar-terrestrial relations. We consider a linear dependence between the radial increment in conifers in Eastern Siberia and solar activity parameters: the length and amplitude of an 11-year solar cycle in the 20th century. It is shown that the increment in conifers in the region is larger in a longer and lower solar cycle than in a short and high one. A correlation between the increment in the width of annual rings of Pinus sylvestris and Siberian pine and the length of the ascending phase of an 11-year cycle is revealed: the longer the ascending phase, the larger the radial increment in conifers. The dynamics of the annual increment in conifers in the region is inversely related to the cycle amplitude and magnetic disturbances in the main solar cycle.

  8. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.

    PubMed

    Patterson, Rainey E; Kalavalapalli, Srilaxmi; Williams, Caroline M; Nautiyal, Manisha; Mathew, Justin T; Martinez, Janie; Reinhard, Mary K; McDougall, Danielle J; Rocca, James R; Yost, Richard A; Cusi, Kenneth; Garrett, Timothy J; Sunny, Nishanth E

    2016-04-01

    The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high-trans-fat high-fructose diet (TFD) for 8 wk to induce simple steatosis and NASH by 24 wk. In vivo fasting hepatic mitochondrial fluxes were determined by(13)C-nuclear magnetic resonance (NMR)-based isotopomer analysis. Hepatic metabolic intermediates were quantified using mass spectrometry-based targeted metabolomics. Hepatic triglyceride accumulation and insulin resistance preceded alterations in mitochondrial metabolism, since TCA cycle fluxes remained normal during simple steatosis. However, mice with NASH had a twofold induction (P< 0.05) of mitochondrial fluxes (μmol/min) through the TCA cycle (2.6 ± 0.5 vs. 5.4 ± 0.6), anaplerosis (9.1 ± 1.2 vs. 16.9 ± 2.2), and pyruvate cycling (4.9 ± 1.0 vs. 11.1 ± 1.9) compared with their age-matched controls. Induction of the TCA cycle activity during NASH was concurrent with blunted ketogenesis and accumulation of hepatic diacylglycerols (DAGs), ceramides (Cer), and long-chain acylcarnitines, suggesting inefficient oxidation and disposal of excess free fatty acids (FFA). Sustained induction of mitochondrial TCA cycle failed to prevent accretion of "lipotoxic" metabolites in the liver and could hasten inflammation and the metabolic transition to NASH.

  9. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.

    PubMed

    Patterson, Rainey E; Kalavalapalli, Srilaxmi; Williams, Caroline M; Nautiyal, Manisha; Mathew, Justin T; Martinez, Janie; Reinhard, Mary K; McDougall, Danielle J; Rocca, James R; Yost, Richard A; Cusi, Kenneth; Garrett, Timothy J; Sunny, Nishanth E

    2016-04-01

    The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high-trans-fat high-fructose diet (TFD) for 8 wk to induce simple steatosis and NASH by 24 wk. In vivo fasting hepatic mitochondrial fluxes were determined by(13)C-nuclear magnetic resonance (NMR)-based isotopomer analysis. Hepatic metabolic intermediates were quantified using mass spectrometry-based targeted metabolomics. Hepatic triglyceride accumulation and insulin resistance preceded alterations in mitochondrial metabolism, since TCA cycle fluxes remained normal during simple steatosis. However, mice with NASH had a twofold induction (P< 0.05) of mitochondrial fluxes (μmol/min) through the TCA cycle (2.6 ± 0.5 vs. 5.4 ± 0.6), anaplerosis (9.1 ± 1.2 vs. 16.9 ± 2.2), and pyruvate cycling (4.9 ± 1.0 vs. 11.1 ± 1.9) compared with their age-matched controls. Induction of the TCA cycle activity during NASH was concurrent with blunted ketogenesis and accumulation of hepatic diacylglycerols (DAGs), ceramides (Cer), and long-chain acylcarnitines, suggesting inefficient oxidation and disposal of excess free fatty acids (FFA). Sustained induction of mitochondrial TCA cycle failed to prevent accretion of "lipotoxic" metabolites in the liver and could hasten inflammation and the metabolic transition to NASH. PMID:26814015

  10. A Cold, Dusty Comet: A Study of Hale-Bopp 8 and 11 Years After Perihelion

    NASA Astrophysics Data System (ADS)

    Kramer, Emily A.; Fernandez, Y. R.; Kelley, M. S.; Woodney, L.

    2009-09-01

    Comet Hale-Bopp offered us an unprecedented opportunity to observe a large, bright comet in great detail. Since its 1997 perihelion, continued observations have let us observe how its activity has changed over time. Here we present 2005 and 2008 Spitzer Space Telescope observations of Hale-Bopp that show a coma and tail, which is uncommon given its heliocentric distance -- 21.6 AU in 2005 and 27.2 AU in 2008. It is rare to see comets with such extended emission this far from the Sun. The data for this project were obtained with the Multiband Imaging Photometer for Spitzer using the 24 micron channel. We are modeling Hale-Bopp's morphology in the Spitzer images to understand the nature of the dust coma and tail. To do this we will use a Monte Carlo dynamical model created by one of our team members[1] that will yield the dust production rate, dust emission history, dust grain sizes, and dust grain speeds. Some questions which will be answered include: How old is the dust? Is it comprised of large, old grains or small, newer grains? What is its likely composition? How does it differ from dust released near perihelion or pre-perihelion? Are the dust properties determined by the comet's activity mechanism? By answering these and other fundamental questions, we hope to gain insight into the nature of Hale-Bopp's behavior and evolution. Our overarching goal is to use Hale-Bopp and other distant, active comets to understand cometary activity and the structure of cometary nuclei, which is related to icy planetesimal formation and evolution. Support for this work was provided by NASA through an award issued by the Spitzer Science Center via JPL/Caltech. Reference: [1] Kelley, M.S., et al., Icarus 193, 572

  11. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation.

    PubMed

    van Weelden, Susanne W H; Fast, Beate; Vogt, Achim; van der Meer, Pieter; Saas, Joachim; van Hellemond, Jaap J; Tielens, Aloysius G M; Boshart, Michael

    2003-04-11

    The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain. Wild type procyclic cells and mutants with targeted deletion of the gene coding for aconitase were derived by synchronous in vitro differentiation from wild type and mutant (Delta aco::NEO/Delta aco::HYG) bloodstream stage parasites, respectively, where aconitase is not expressed and is dispensable. No differences in intracellular levels of glycolytic and Krebs cycle intermediates were found in procyclic wild type and mutant cells, except for citrate that accumulated up to 90-fold in the mutants, confirming the absence of aconitase activity. Surprisingly, deletion of aconitase did not change differentiation nor the growth rate or the intracellular ATP/ADP ratio in those cells. Metabolic studies using radioactively labeled substrates and NMR analysis demonstrated that glucose and proline were not degraded via the Krebs cycle to CO(2). Instead, glucose was degraded to acetate, succinate, and alanine, whereas proline was degraded to succinate. Importantly, there was absolutely no difference in the metabolic products released by wild type and aconitase knockout parasites, and both were for survival strictly dependent on respiration via the mitochondrial electron transport chain. Hence, although the Krebs cycle enzymes are present, procyclic T. brucei do not use Krebs cycle activity for energy generation, but the mitochondrial respiratory chain is essential for survival and growth. We therefore propose a revised model of the energy metabolism of procyclic T. brucei.

  12. Cycling induced by electrical stimulation improves muscle activation and symmetry during pedaling in hemiparetic patients.

    PubMed

    Ambrosini, Emilia; Ferrante, Simona; Ferrigno, Giancarlo; Molteni, Franco; Pedrocchi, Alessandra

    2012-05-01

    A randomized controlled trial, involving 35 post-acute hemiparetic patients, demonstrated that a four-week treatment of cycling induced by functional electrical stimulation (FES-cycling) promotes motor recovery. Analyzing additional data acquired during that study, the present work investigated whether these improvements were associated to changes in muscle strength and motor coordination. Participants were randomized to receive FES-cycling or placebo FES-cycling. Clinical outcome measures were: the Motricity Index (MI), the gait speed, the electromyography activation of the rectus femoris and biceps femoris, and the mechanical work produced by each leg during voluntary pedaling. To provide a comparison with normal values, healthy adults also carried out the pedaling test. Patients were evaluated before, after training, and at follow-up visits. A significant treatment effect in favor of FES-treated patients was found in terms of MI scores and unbalance in mechanical works, while differences in gait speed were not significant (ANCOVA). Significant improvements in the activation of the paretic muscles were highlighted in the FES group, while no significant change was found in the placebo group (Friedman test). Our findings suggested that improvements in motor functions induced by FES-cycling training were associated with a more symmetrical involvement of the two legs and an improved motor coordination. PMID:22514205

  13. Microbial activities and phosphorus cycling: An application of oxygen isotope ratios in phosphate

    NASA Astrophysics Data System (ADS)

    Stout, Lisa M.; Joshi, Sunendra R.; Kana, Todd M.; Jaisi, Deb P.

    2014-08-01

    Microorganisms carry out biochemical transformations of nutrients that make up their cells. Therefore, understanding how these nutrients are transformed or cycled in natural environments requires knowledge of microbial activity. Commonly used indicators for microbial activity typically include determining microbial respiration by O2/CO2 measurements, cell counts, and measurement of enzyme activities. However, coupled studies on nutrient cycling and microbial activity are not given enough emphasis. Here we apply phosphate oxygen isotope ratios (δ18OP) as a tool for measurement of microbial activity and compare the rate of isotope exchange with methods of measuring microbial activities that are more commonly applied in environmental studies including respiration, dehydrogenase activity, alkaline phosphatase activity, and cell counts. Our results show that different bacteria may have different strategies for P uptake, storage and release, their respiration and consequently expression of DHA and APase activities, but in general the trend of their enzyme activities are comparable. Phosphate δ18OP values correlated well with these other parameters used to measure microbial activity with the strongest linear relationships between δ18OP and CO2 evolution (r = -0.99). Even though the rate of isotope exchange for each microorganism used in this study is different, the rate per unit CO2 respiration showed one general trend, where δ18OP values move towards equilibrium while CO2 is generated. While this suggests that P cycling among microorganisms used in this study can be generalized, further research is needed to determine whether the microorganism-specific isotope exchange trend may occur in natural environments. In summary, phosphate oxygen isotope measurements may offer an alternative for use as a tracer to measure microbial activity in soils, sediments, and many other natural environments.

  14. Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

    PubMed Central

    Hukasova, Elvira; Silva Cascales, Helena; Kumar, Shravan R.; Lindqvist, Arne

    2012-01-01

    Förster resonance energy transfer (FRET)-based reporters1 allow the assessment of endogenous kinase and phosphatase activities in living cells. Such probes typically consist of variants of CFP and YFP, intervened by a phosphorylatable sequence and a phospho-binding domain. Upon phosphorylation, the probe changes conformation, which results in a change of the distance or orientation between CFP and YFP, leading to a change in FRET efficiency (Fig 1). Several probes have been published during the last decade, monitoring the activity balance of multiple kinases and phosphatases, including reporters of PKA2, PKB3, PKC4, PKD5, ERK6, JNK7, Cdk18, Aurora B9 and Plk19. Given the modular design, additional probes are likely to emerge in the near future10. Progression through the cell cycle is affected by stress signaling pathways 11. Notably, the cell cycle is regulated differently during unperturbed growth compared to when cells are recovering from stress12.Time-lapse imaging of cells through the cell cycle therefore requires particular caution. This becomes a problem particularly when employing ratiometric imaging, since two images with a high signal to noise ratio are required to correctly interpret the results. Ratiometric FRET imaging of cell cycle dependent changes in kinase and phosphatase activities has predominately been restricted to sub-sections of the cell cycle8,9,13,14. Here, we discuss a method to monitor FRET-based probes using ratiometric imaging throughout the human cell cycle. The method relies on equipment that is available to many researchers in life sciences and does not require expert knowledge of microscopy or image processing. PMID:22314640

  15. Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle.

    PubMed

    Lewis, Robert; Curtis, J Thomas

    2016-03-15

    Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In humans, blood pressure decreases during the resting phase of the activity cycle, and the magnitude of that "nocturnal dipping" has been used to stratify patients according to the risk for cardiovascular disease. However, in contrast to most mammals, prairie voles (Microtus ochrogaster) have periods of activity and rest that follow an ultradian rhythm with period lengths significantly <24h. While rhythmic changes in blood pressure across a circadian activity cycle have been well-documented, blood pressure patterns in species that display ultradian rhythms in activity are less well-studied. In the current study, we implanted pressure-sensitive radiotelemetry devices in male prairie voles and recorded activity, mean arterial pressure (MAP), and heart rate (HR) continuously for 3days. Visualization of the ultradian rhythms was enhanced using a 1h running average to filter the dataset. Positive correlations were found between activity and MAP and between activity and HR. During the inactive period of the ultradian cycle, blood pressure decreased by about 15%, which parallels the nocturnal dipping pattern seen in healthy humans. Further, the duration of inactivity did not affect any of the cardiovascular measures, so the differences in blood pressure values between the active and inactive periods are likely driven by ultradian oscillations in hormones and autonomic function. Finally, specific behavioral patterns also were examined. Both the instrumented animal and his non-instrumented cagemate appeared to show synchronized activity patterns, with both animals displaying sleep-like behavior for more than 90% of the inactive period. We propose that the prairie vole ultradian rhythm in blood pressure is an analogue for circadian blood pressure variability

  16. Study of Distribution and Asymmetry of Solar Active Prominences during Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Joshi, Navin Chandra; Bankoti, Neeraj Singh; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2009-12-01

    In this article we present the results of a study of the spatial distribution and asymmetry of solar active prominences (SAP) for the period 1996 through 2007 (solar cycle 23). For more meaningful statistical analysis we analyzed the distribution and asymmetry of SAP in two subdivisions viz. Group1 (ADF, APR, DSF, CRN, CAP) and Group2 (AFS, ASR, BSD, BSL, DSD, SPY, LPS). The North - South (N - S) latitudinal distribution shows that the SAP events are most prolific in the 21° to 30° slice in the Northern and Southern Hemispheres; the East - West (E - W) longitudinal distribution study shows that the SAP events are most prolific (best observable) in the 81° to 90° slice in the Eastern and Western Hemispheres. It was found that the SAP activity during this cycle is low compared to previous solar cycles. The present study indicates that during the rising phase of the cycle the number of SAP events are roughly equal in the Northern and Southern Hemispheres. However, activity in the Southern Hemisphere has been dominant since 1999. Our statistical study shows that the N - S asymmetry is more significant then the E - W asymmetry.

  17. Stellar activity cycles from long-term data by robotic telescopes

    NASA Astrophysics Data System (ADS)

    Oláh, K.

    2014-03-01

    All results about stellar activity cycles stem from decades-long systematic observations that were done by small telescopes. Without these equipments we would not know much, if anything, about stellar activity cycles, like those we see and observe easily on the nearest star, the Sun. In the early 80's of the last century systematic photometric monitoring of active stars began with automated photometric telescopes (APTs), some of which continue the observations to date. The Vienna-Potsdam APT now works for about two decades (Strassmeier et al. 1997), similarly to the 4-College Consortium APT (Dukes et al. 1995), while the Catania APT (Rodono et al. 2001) was closed down a few years ago. These small tools with the same setups for decades do not cost much and are relatively cheap to maintain. The longest continuous photometric datasets of a few objects from APTs span now over 30 years, which, together with earlier, manually-obtained data allow to study those activity cycles of stars which are in the order of 10 years or shorter: to be sure in the timescale of a cycle it should be observed repeatedly at least 2-3 times. The spectroscopic automated telescope STELLA (Strassmeier et al. 2004), built in the first decade of this century, measured already a few dozens of radial velocity curves for long-period binary stars and measured their activity levels (Strassmeier et al. 2012); these results can be gathered only by robotic telescopes. Only with STELLA it is possible to study the decades-long behavior of starspots on active giants with long rotational periods via Doppler Imaging. As the databases were growing it became clear that stars, just as the Sun, had multiple cycles. It was also found that stellar cycles showed systematic changes and that the cycle lengths correlated with the rotational periods of the stars. Extensive summaries of stellar activity cycles are found in Baliunas et al. (1995) using the Mt. Wilson Ca-index survey, and Oláh et al. (2009) based on

  18. Content analysis of the Journal of Counseling Psychology: Buboltz, Miller, and Williams (1999) 11 years later.

    PubMed

    Buboltz, Walter; Deemer, Eric; Hoffmann, Rebecca

    2010-07-01

    A content analysis of research published in the Journal of Counseling Psychology (JCP) was conducted for Volumes 46 (1999) through 56 (2009). The analysis involved the placement of 514 articles in 15 substantive content categories. In addition, we identified the most frequently published authors, most frequent institutional affiliations, and several reported demographic characteristics. The principal areas of research activity in the JCP were multiculturalism and/or diversity, research on development and evaluation of tests and measures, personality and adjustment, outcome research, and interpersonal and/or social support and/or attachment, with these categories accounting for 57% of the articles published. Over 40% of the samples reported were college students, with a large number of samples including both genders and indicating the ethnic breakdown. This content analysis revealed that the JCP has remained consistent with its stated mission while incorporating changes in the field in its publications.

  19. Individual, family, and neighborhood correlates of independent mobility among 7 to 11-year-olds

    PubMed Central

    Janssen, Ian; Ferrao, Thomas; King, Nathan

    2015-01-01

    Objective. Independent mobility refers to the freedom that children have to move around their neighborhood without adult supervision. It is related to their physical activity and health. We examined the intrapersonal, family, and neighborhood correlates of independent mobility within children. Methods. 497 American parents of 6.9–11.9 year olds completed a survey (November, 2014) that assessed their child's independent mobility range, several intrapersonal characteristics of their child (gender, age, race, etc.), several characteristics of their family (family structure, socioeconomic status, parental physical activity, etc.), and their perceptions of the safety of their neighborhood (18 questions reduced to 4 components). Associations were determined using ordinal logistic regression. Results. Children's age, parent's perception that their neighborhood is safe for children, and parent's fear of neighborhood crime were the independent correlates of independent mobility. Compared to 6.9–7.9 year olds, the odds ratio (95% CI) for increasing independent mobility were 2.31 (1.47–3.64) in 8.0–9.9 year olds and 3.38 (2.13–5.36) in 10.0–11.9 year olds. Compared to children whose parents who did not perceive that their neighborhood was safe for children, the odds ratio for increasing independent mobility was 4.24 (2.68–6.70) for children whose parents perceived their neighborhood was safe for children. Compared to children whose parents had the lowest fear of neighborhood crime, the odds ratio for increasing independent mobility was 0.41 (0.27–0.62) for children whose parents had the highest fear of crime. Conclusions. Children's independent mobility was associated with their age, their parent's perception that their neighborhood was safe for children, and their parent's fear of crime. PMID:26844195

  20. Individual, family, and neighborhood correlates of independent mobility among 7 to 11-year-olds.

    PubMed

    Janssen, Ian; Ferrao, Thomas; King, Nathan

    2016-06-01

    Objective. Independent mobility refers to the freedom that children have to move around their neighborhood without adult supervision. It is related to their physical activity and health. We examined the intrapersonal, family, and neighborhood correlates of independent mobility within children. Methods. 497 American parents of 6.9-11.9 year olds completed a survey (November, 2014) that assessed their child's independent mobility range, several intrapersonal characteristics of their child (gender, age, race, etc.), several characteristics of their family (family structure, socioeconomic status, parental physical activity, etc.), and their perceptions of the safety of their neighborhood (18 questions reduced to 4 components). Associations were determined using ordinal logistic regression. Results. Children's age, parent's perception that their neighborhood is safe for children, and parent's fear of neighborhood crime were the independent correlates of independent mobility. Compared to 6.9-7.9 year olds, the odds ratio (95% CI) for increasing independent mobility were 2.31 (1.47-3.64) in 8.0-9.9 year olds and 3.38 (2.13-5.36) in 10.0-11.9 year olds. Compared to children whose parents who did not perceive that their neighborhood was safe for children, the odds ratio for increasing independent mobility was 4.24 (2.68-6.70) for children whose parents perceived their neighborhood was safe for children. Compared to children whose parents had the lowest fear of neighborhood crime, the odds ratio for increasing independent mobility was 0.41 (0.27-0.62) for children whose parents had the highest fear of crime. Conclusions. Children's independent mobility was associated with their age, their parent's perception that their neighborhood was safe for children, and their parent's fear of crime.

  1. Solar magnetic activity cycles, coronal potential field models and eruption rates

    NASA Astrophysics Data System (ADS)

    Petrie, Gordon

    2013-07-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun (SOLIS) vector spectro-magnetograph (VSM), the spectro-magnetograph and the 512-channel magnetograph instruments, and from the U. Stanford's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking (CACTus), Solar Eruptive Event Detection System (SEEDS), and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003-2012 than for those between 1997-2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  2. Past and future trends in stellar activity cycle research: beyond Ca II H&K

    NASA Astrophysics Data System (ADS)

    Hall, Jeffrey C.

    2002-06-01

    Olin C. Wilson began stellar activity cycle research in 1966, and work has since proceeded along a number of observational and theoretical lines. Long-term ground-based spectroscopic monitoring of the Ca II H&K activity proxies has demonstrated the existence of varying types of stellar cycles, while complementary photometric studies have revealed luminosity variations both in phase and in antiphase with chromospheric activity. Beginning in the late 1970s, space-based observations greatly affected our understanding of stellar chromospheres, spurring a complementary evolution in interpretation of the ground-based results. Excellent recent reviews of the results of these programs have appeared, so in this paper, I will summarize the results and review them in the broad context of the development of our present state of knowledge, current outstanding questions and pitfalls facing workers in the field today, and the lines of investigation likely to be fruitful in the next decade.

  3. Effects of Space Weather on Biomedical Parameters during the Solar Activity Cycles 23-24.

    PubMed

    Ragul'skaya, M V; Rudenchik, E A; Chibisov, S M; Gromozova, E N

    2015-06-01

    The results of long-term (1998-2012) biomedical monitoring of the biotropic effects of space weather are discussed. A drastic change in statistical distribution parameters in the middle of 2005 was revealed that did not conform to usual sinusoidal distribution of the biomedical data reflecting changes in the number of solar spots over a solar activity cycle. The dynamics of space weather of 2001-2012 is analyzed. The authors hypothesize that the actual change in statistical distributions corresponds to the adaptation reaction of the biosphere to nonstandard geophysical characteristics of the 24th solar activity cycle and the probable long-term decrease in solar activity up to 2067. PMID:26085362

  4. Magnetic activity of red secondaries: clues from the outburst cycle variations of dwarf novae

    NASA Astrophysics Data System (ADS)

    Chinarova, L. L.

    Photometric variations of 6 dwarf novae stars are studied based on the photographic observations from the Odessa, Moscow and Sonneberg plate collections and published visual monitoring data from the AFOEV database (Schweitzer E.: 1993, Bull. AFOEV, 64, 14). The moments of maxima are determined by using the "running parabola" fit (Andronov I.L., 1990, Kinematika Fizika Nebesn. Tel., v.6,,N 6, 87) with automatically determined filter half-width (Andronov I.L., 1997, As.Ap. Suppl., in press). All investigated stars exhibit significant changes not only from cycle-to-cycle, but from season-to-season as well. Secondary decade-scale cycles of smooth variations (Bianchini A., 1990, AJ 99, 1941) and abrupt switchings (Andronov I.L., Shakun L.I., 1990, ASS 169, 237) were interpreted by a solar-type activity of the red dwarf secondary in a binary system and may argue for existence of two different subgroups of the dwarf novae.

  5. Surface flux transport simulations. Inflows towards active regions and the modulation of the solar cycle.

    NASA Astrophysics Data System (ADS)

    Martin-Belda, David; Cameron, Robert

    2016-07-01

    Aims. We investigate the way near-surface converging flows towards active regions affect the build-up of magnetic field at the Sun's polar caps. In the Babcock-Leighton dynamo framework, this modulation of the polar fields could explain the variability of the solar cycle. Methods. We develop a surface flux transport code incorporating a parametrized model of the inflows and run simulations spanning several cycles. We carry out a parameter study to test how the strength and extension of the inflows affect the amplitude of the polar fields. Results. Inflows are seen to play an important role in the build-up of the polar fields, and can act as the non-linearity feedback mechanism required to limit the strength of the solar cycles in the Babcock-Leighton dynamo framework.

  6. PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.

    PubMed

    Gonnella, Roberta; Granato, Marisa; Farina, Antonella; Santarelli, Roberta; Faggioni, Alberto; Cirone, Mara

    2015-07-01

    PKC activation by combining TPA with sodium butyrate (T/B) represents the most effective and widely used strategy to induce the Epstein-Barr virus (EBV) lytic cycle. The results obtained in this study show that novel PKCθ is involved in such process and that it acts through the activation of p38 MAPK and autophagy induction. Autophagy, a mechanism of cellular defense in stressful conditions, is manipulated by EBV to enhance viral replication. Besides promoting the EBV lytic cycle, the activation of p38 and autophagy resulted in a pro-survival effect, as indicated by p38 or ATG5 knocking down experiments. However, this pro-survival role was counteracted by a pro-death activity of PKCθ, due to the dephosphorylation of AKT. In conclusion, this study reports, for the first time, that T/B activates a PKCθ-p38 MAPK axis in EBV infected B cells, that promotes the viral lytic cycle and cell survival and dephosphorylates AKT, balancing cell life and cell death. PMID:25827954

  7. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

    PubMed Central

    Sidor, Michelle M.; Spencer, Sade M.; Dzirasa, Kafui; Parekh, Puja K.; Tye, Kay M.; Warden, Melissa R.; Arey, Rachel N.; Enwright, John F; Jacobsen, Jacob PR; Kumar, Sunil; Remillard, Erin M; Caron, Marc G.; Deisseroth, Karl; McClung, Colleen A

    2014-01-01

    Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a period of euthymia at night. Mood cycling coincides with abnormal daytime spikes in ventral tegmental area (VTA) dopaminergic activity, tyrosine hydroxylase (TH) levels, and dopamine synthesis. To determine the significance of daytime increases in VTA dopamine activity to manic behaviors, we developed a novel optogenetic stimulation paradigm that produces a sustained increase in dopamine neuronal activity and find that this induces a manic-like behavioral state. Time-dependent dampening of TH activity during the day reverses manic-related behaviours in ClockΔ19 mice. Finally, we show that CLOCK acts as a negative regulator of TH transcription, revealing a novel molecular mechanism underlying cyclic changes in mood-related behaviour. Taken together, these studies have identified a mechanistic connection between circadian gene disruption and the precipitation of manic episodes in bipolar disorder. PMID:25560763

  8. PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.

    PubMed

    Gonnella, Roberta; Granato, Marisa; Farina, Antonella; Santarelli, Roberta; Faggioni, Alberto; Cirone, Mara

    2015-07-01

    PKC activation by combining TPA with sodium butyrate (T/B) represents the most effective and widely used strategy to induce the Epstein-Barr virus (EBV) lytic cycle. The results obtained in this study show that novel PKCθ is involved in such process and that it acts through the activation of p38 MAPK and autophagy induction. Autophagy, a mechanism of cellular defense in stressful conditions, is manipulated by EBV to enhance viral replication. Besides promoting the EBV lytic cycle, the activation of p38 and autophagy resulted in a pro-survival effect, as indicated by p38 or ATG5 knocking down experiments. However, this pro-survival role was counteracted by a pro-death activity of PKCθ, due to the dephosphorylation of AKT. In conclusion, this study reports, for the first time, that T/B activates a PKCθ-p38 MAPK axis in EBV infected B cells, that promotes the viral lytic cycle and cell survival and dephosphorylates AKT, balancing cell life and cell death.

  9. Necessary Conditions for Tropical Cyclone Rapid Intensification as Derived from 11 Years of TRMM Data

    NASA Astrophysics Data System (ADS)

    Jiang, H.; Ramirez, E. M.

    2012-12-01

    Understanding and predicting intensity changes, especially rapid intensification (RI), of tropical cyclones (TCs) require some understanding of not only the large-scale environment condition, but also the convective and precipitation properties of the storm. Convective and rainfall properties of TCs are statistically quantified for different TC intensity change categories by using Tropical Rainfall Measuring Mission (TRMM) data from December 1997 to December 2008. Four 24-h future intensity change categories are defined: rapidly intensifying (RI), slowly intensifying, neutral, and weakening. Maximum convective intensity in the inner core is not necessarily more intense prior to undergoing an RI episode than a slowly intensifying, neutral, or weakening episode. Instead, a minimum threshold of convective intensity, raining area, and total volumetric rain in the inner core has to be reached before a storm undergoes RI. The following necessary conditions for RI are found in the inner core: maximum near surface radar reflectivity > 40 dBZ, maximum 20 (30, 40) dBZ echo height > 8 (6, 4) km, minimum 85 (37) GHz polarization corrected brightness temperature (PCT) < 235 (275) K, minimum 10.8 μm brightness temperature < 220 K, total raining area > 3,000 km^2, and total volumetric rain > 5,000 mm h-1 km^2. It is also found that total lightning activities in the inner core (outer rainband) have a negative (positive) relationship with storm intensification.

  10. Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells.

    PubMed

    Fyrberg, A; Mirzaee, S; Lotfi, K

    2006-01-01

    Activation of nucleoside analogues is dependent on kinases and 5'-nucleotidases and the balance between the activity of these enzymes. The purpose of this study was to analyze deoxycytidine kinase, deoxyguanosine kinase, and 4 different 5'-nucleotidases during cell cycle progression in MOLT-4 cells. The activity of both kinases was cell cycle dependent and increased during proliferation while the activity of cytosolic 5'-nucleotidase I decreased. We could show that the kinase activity was higher than the total nucleotidase activity, which was unchanged or decreased during cell cycle progression. These data may be important in designing modern combination therapy with nucleoside analogues.

  11. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin

    PubMed Central

    Solarewicz, Julia Z.; Angoa-Perez, Mariana; Kuhn, Donald M.; Mateika, Jason H.

    2016-01-01

    We examined the role that serotonin has in the modulation of sleep and wakefulness across a 12-h:12-h light-dark cycle and determined whether temperature and motor activity are directly responsible for potential disruptions to arousal state. Telemetry transmitters were implanted in 24 wild-type mice (Tph2+/+) and 24 mice with a null mutation for tryptophan hydroxylase 2 (Tph2−/−). After surgery, electroencephalography, core body temperature, and motor activity were recorded for 24 h. Temperature for a given arousal state (quiet and active wake, non-rapid eye movement, and paradoxical sleep) was similar in the Tph2+/+ and Tph2−/− mice across the light-dark cycle. The percentage of time spent in active wakefulness, along with motor activity, was decreased in the Tph2+/+ compared with the Tph2−/− mice at the start and end of the dark cycle. This difference persisted into the light cycle. In contrast, the time spent in a given arousal state was similar at the remaining time points. Despite this similarity, periods of non-rapid-eye-movement sleep and wakefulness were less consolidated in the Tph2+/+ compared with the Tph2−/− mice throughout the light-dark cycle. We conclude that the depletion of serotonin does not disrupt the diurnal variation in the sleep-wake cycle, motor activity, and temperature. However, serotonin may suppress photic and nonphotic inputs that manifest at light-dark transitions and serve to shorten the ultraradian duration of wakefulness and non-rapid-eye-movement sleep. Finally, alterations in the sleep-wake cycle following depletion of serotonin are unrelated to disruptions in the modulation of temperature. PMID:25394829

  12. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

    PubMed

    Solarewicz, Julia Z; Angoa-Perez, Mariana; Kuhn, Donald M; Mateika, Jason H

    2015-01-01

    We examined the role that serotonin has in the modulation of sleep and wakefulness across a 12-h:12-h light-dark cycle and determined whether temperature and motor activity are directly responsible for potential disruptions to arousal state. Telemetry transmitters were implanted in 24 wild-type mice (Tph2(+/+)) and 24 mice with a null mutation for tryptophan hydroxylase 2 (Tph2(-/-)). After surgery, electroencephalography, core body temperature, and motor activity were recorded for 24 h. Temperature for a given arousal state (quiet and active wake, non-rapid eye movement, and paradoxical sleep) was similar in the Tph2(+/+) and Tph2(-/-) mice across the light-dark cycle. The percentage of time spent in active wakefulness, along with motor activity, was decreased in the Tph2(+/+) compared with the Tph2(-/-) mice at the start and end of the dark cycle. This difference persisted into the light cycle. In contrast, the time spent in a given arousal state was similar at the remaining time points. Despite this similarity, periods of non-rapid-eye-movement sleep and wakefulness were less consolidated in the Tph2(+/+) compared with the Tph2(-/-) mice throughout the light-dark cycle. We conclude that the depletion of serotonin does not disrupt the diurnal variation in the sleep-wake cycle, motor activity, and temperature. However, serotonin may suppress photic and nonphotic inputs that manifest at light-dark transitions and serve to shorten the ultraradian duration of wakefulness and non-rapid-eye-movement sleep. Finally, alterations in the sleep-wake cycle following depletion of serotonin are unrelated to disruptions in the modulation of temperature.

  13. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

    PubMed Central

    Pumiglia, Kevin M.; Decker, Stuart J.

    1997-01-01

    The mitogen-activated protein kinase (MAPK) cascade plays a crucial role in the transduction of extracellular signals into responses governing growth and differentiation. The effects of a specific inhibitor of the MAPK kinase (MEK)/MAPK pathway (PD98059) on nerve growth factor (NGF)-induced growth arrest and inhibition of cell cycle-dependent kinases (CDKs) have been examined. Treatment of NIH 3T3 cells expressing TRKA with PD98059 dramatically reversed the complete inhibition of growth of these cells caused by NGF. PD98059 also blocked the ability of NGF to inhibit the activities of CDK4 and CDK2, while partially preventing NGF induction of p21Cip1/WAF1. To independently evaluate the involvement of the MEK/MAPK pathway in growth arrest, an inducible activated form of the Raf-1 protooncogene (ΔRAF-1:ER) was expressed in these cells. Activation of ΔRAF-1:ER resulted in a prolonged increase in MAPK activity and growth arrest of these cells, with concomitant induction of p21Cip1/WAF1 and inhibition of CDK2 activity. These effects of ΔRAF-1:ER activation were all reversed by treatment of cells with PD98059. These data indicate that in addition to functioning as a positive effector of growth, stimulation of the MEK/MAPK pathway can result in an inhibition of CDK activity and cell cycle arrest. PMID:9012803

  14. Effect of mixing water magnetic activation cycle on cement stone structure

    NASA Astrophysics Data System (ADS)

    Kugaevskaya, S. A.; Abzaev, Yu A.; Safronov, V. N.; Sarkisov, Yu S.; Gorlenko, N. P.; Ermilova, T. A.

    2015-01-01

    The paper presents results of investigations of hydration processes and structure formation of the cement paste matrix mixed with water activated by magneto static field using water treatment cycle technology. It is shown that crystallization of phases occurs in the cement-water system at different rates, and phase redistribution in the structure of the cement paste matrix is described before and after magnetic activation of mixing water. Also, modeling of the cement-water system and calculations of amorphous and crystalline phases using the Rietveld refinement method before and after magnetic activation show that strength properties of the cement paste matrix depend not only on quantitative but also qualitative relationship between phases.

  15. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.

    PubMed

    Morrish, F; Isern, N; Sadilek, M; Jeffrey, M; Hockenbery, D M

    2009-07-01

    Cell proliferation requires the coordinated activity of cytosolic and mitochondrial metabolic pathways to provide ATP and building blocks for DNA, RNA and protein synthesis. Many metabolic pathway genes are targets of the c-myc oncogene and cell-cycle regulator. However, the contribution of c-Myc to the activation of cytosolic and mitochondrial metabolic networks during cell-cycle entry is unknown. Here, we report the metabolic fates of [U-(13)C] glucose in serum-stimulated myc(-/-) and myc(+/+) fibroblasts by (13)C isotopomer NMR analysis. We demonstrate that endogenous c-myc increased (13)C labeling of ribose sugars, purines and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux. Myc expression also increased global O-linked N-acetylglucosamine protein modification, and inhibition of hexosamine biosynthesis selectively reduced growth of Myc-expressing cells, suggesting its importance in Myc-induced proliferation. These data reveal a central organizing function for the Myc oncogene in the metabolism of cycling cells. The pervasive deregulation of this oncogene in human cancers may be explained by its function in directing metabolic networks required for cell proliferation.

  16. Effect of seat positions on discomfort, muscle activation, pressure distribution and pedal force during cycling.

    PubMed

    Verma, Rachita; Hansen, Ernst A; de Zee, Mark; Madeleine, Pascal

    2016-04-01

    The aim of this study was to measure and analyse discomfort and biomechanics of cycling, i.e., muscle activation, centre of pressure of seat pressure profiles and pedal forces as a function of seat position. Twenty-one recreationally active individuals cycled for 10min at 100W on an ergometer cycle using five different seat positions. The neutral position was considered as basic seat position and was compared with upward, downward, forward and backward seat positions. The initial bout was repeated at the end of the recording session. Discomfort increased for upward and backward condition compared with neutral (P<0.05). Normalized surface electromyography from gastrocnemius decreased in the downward and forward position but increased in the upward and backward position. The minimum force became less negative for forward position compared with neutral seat position (P<0.05). The degree of variability of centre of pressure increased in the upward and backward position and the entropy of the centre of pressure of sitting posture for backward position decreased compared with neutral seat position (P<0.05). The present study revealed that consecutive changes of seat position over time lead to increase in discomfort as well as alterations of the biomechanics of cycling. PMID:26938676

  17. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.

    SciTech Connect

    Morrish, Fionnuala M.; Isern, Nancy; Sadilek, Martin; Jeffrey, Mark; Hockenbery, David M.

    2009-05-18

    Cell proliferation requires the coordinated activity of cytosolic and mitochondrial metabolic pathways to provide ATP and building blocks for DNA, RNA, and protein synthesis. Many metabolic pathway genes are targets of the c-myc oncogene and cell cycle regulator. However, the contribution of c-Myc to the activation of cytosolic and mitochondrial metabolic networks during cell cycle entry is unknown. Here, we report the metabolic fates of [U-13C] glucose in serum-stimulated myc-/- and myc+/+ fibroblasts by 13C isotopomer NMR analysis. We demonstrate that endogenous c-myc increased 13C-labeling of ribose sugars, purines, and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux. Myc expression also increased global O-linked GlcNAc protein modification, and inhibition of hexosamine biosynthesis selectively reduced growth of Myc-expressing cells, suggesting its importance in Myc-induced proliferation. These data reveal a central organizing role for the Myc oncogene in the metabolism of cycling cells. The pervasive deregulation of this oncogene in human cancers may be explained by its role in directing metabolic networks required for cell proliferation.

  18. Polarity Reversal of the Solar Photospheric Magnetic Field During Activity Cycle 24

    NASA Astrophysics Data System (ADS)

    Sun, Xudong; Hoeksema, Jon Todd; Liu, Yang; Zhao, Junwei

    2014-06-01

    The large-scale solar magnetic field reverses its polarity during the maximum phase of each activity cycle. As observed on the photosphere, active region (AR) magnetic flux migrates poleward in narrow, sheared streams resulted from large-scale flows and diffusion. A small net flux of the trailing sunspot polarity eventually aggregates at high latitudes, manifesting the poloidal field of the next cycle. We characterize this process for the ongoing cycle 24 based on four years' line-of-sight magnetograms from the Helioseismic and Magnetic Imager (HMI). The axial dipole component reversed sign in early 2012, but the poleward flux migration was grossly out of phase in the two hemispheres. As a proxy, the northern polar field (taken as mean above 70 degrees latitude) switched from negative to positive in late 2012, whereas the southern remained positive as of March 2014. Three factors that are in line with the surface flux transport model may have contributed. First, AR emergence started and peaked earlier in the north. Second, several ARs with small or inverse tilt angles (w.r.t. the Joy's law) emerged in the south in late 2010. Third, meridional flow speed inferred from helioseismology varied greatly prior to 2013; slower streams (compared to a three-year mean at the same latitude) appeared earlier in the north. We correlate HMI with the long-running Wilcox Solar Observatory (WSO) dataset, and compare the current cycle with the previous three.

  19. Effectiveness and Student Perceptions of an Active Learning Activity Using a Headline News Story to Enhance In-Class Learning of Cell Cycle Regulation

    ERIC Educational Resources Information Center

    Dirks-Naylor, Amie J.

    2016-01-01

    An active learning activity was used to engage students and enhance in-class learning of cell cycle regulation in a PharmD level integrated biological sciences course. The aim of the present study was to determine the effectiveness and perception of the in-class activity. After completion of a lecture on the topic of cell cycle regulation,…

  20. Cell cycle arrest and activation of development in marine invertebrate deuterostomes.

    PubMed

    Costache, Vlad; McDougall, Alex; Dumollard, Rémi

    2014-08-01

    Like most metazoans, eggs of echinoderms and tunicates (marine deuterostomes, there is no data for the cephalochordates) arrest awaiting fertilization due to the activity of the Mos/MEK/MAPK cascade and are released from this cell cycle arrest by sperm-triggered Ca2+ signals. Invertebrate deuterostome eggs display mainly three distinct types of cell cycle arrest before fertilization mediated by potentially different cytostatic factors (CSF): one CSF causes arrest during meiotic metaphase I (MI-CSF in tunicates and some starfishes), another CSF likely causes arrest during meiotic metaphase II (amphioxus), and yet another form of CSF causes arrest to occur after meiotic exit during G1 of the first mitotic cycle (G1-CSF). In tunicates and echinoderms these different CSF activities have been shown to rely on the Mos//MAPK pathway for establishment and on Ca2+ signals for their inactivation. Despite these molecular similarities, release of MI-CSF arrest is caused by APC/C activation (to destroy cyclin B) whereas release from G1-CSF is caused by stimulating S phase and the synthesis of cyclins. Further research is needed to understand how both the Mos//MAPK cascade and Ca2+ achieve these tasks in different marine invertebrate deuterostomes. Another conserved feature of eggs is that protein synthesis of specific mRNAs is necessary to proceed through oocyte maturation and to maintain CSF-induced cell cycle arrest. Then activation of development at fertilization is accompanied by an increase in the rate of protein synthesis but the mechanisms involved are still largely unknown in most of the marine deuterostomes. How the sperm-triggered Ca2+ signals cause an increase in protein synthesis has been studied mainly in sea urchin eggs. Here we review these conserved features of eggs (arrest, activation and protein synthesis) focusing on the non-vertebrate deuterostomes. PMID:24721426

  1. Cell cycle arrest and activation of development in marine invertebrate deuterostomes.

    PubMed

    Costache, Vlad; McDougall, Alex; Dumollard, Rémi

    2014-08-01

    Like most metazoans, eggs of echinoderms and tunicates (marine deuterostomes, there is no data for the cephalochordates) arrest awaiting fertilization due to the activity of the Mos/MEK/MAPK cascade and are released from this cell cycle arrest by sperm-triggered Ca2+ signals. Invertebrate deuterostome eggs display mainly three distinct types of cell cycle arrest before fertilization mediated by potentially different cytostatic factors (CSF): one CSF causes arrest during meiotic metaphase I (MI-CSF in tunicates and some starfishes), another CSF likely causes arrest during meiotic metaphase II (amphioxus), and yet another form of CSF causes arrest to occur after meiotic exit during G1 of the first mitotic cycle (G1-CSF). In tunicates and echinoderms these different CSF activities have been shown to rely on the Mos//MAPK pathway for establishment and on Ca2+ signals for their inactivation. Despite these molecular similarities, release of MI-CSF arrest is caused by APC/C activation (to destroy cyclin B) whereas release from G1-CSF is caused by stimulating S phase and the synthesis of cyclins. Further research is needed to understand how both the Mos//MAPK cascade and Ca2+ achieve these tasks in different marine invertebrate deuterostomes. Another conserved feature of eggs is that protein synthesis of specific mRNAs is necessary to proceed through oocyte maturation and to maintain CSF-induced cell cycle arrest. Then activation of development at fertilization is accompanied by an increase in the rate of protein synthesis but the mechanisms involved are still largely unknown in most of the marine deuterostomes. How the sperm-triggered Ca2+ signals cause an increase in protein synthesis has been studied mainly in sea urchin eggs. Here we review these conserved features of eggs (arrest, activation and protein synthesis) focusing on the non-vertebrate deuterostomes.

  2. Developmental pathways of language and social communication problems in 9-11 year olds: unpicking the heterogeneity.

    PubMed

    Roy, P; Chiat, S

    2014-10-01

    This paper addressed relations between language, social communication and behaviour, and their trajectories, in a sample of 9-11-year-olds (n=91) who had been referred to clinical services with concerns about language as pre-schoolers. Children were first assessed at 2½-4 years, and again 18 months later. Results revealed increasing differentiation of profiles across time. By 9-11 years, 11% of the sample had social communication deficits, 27% language impairment, 20% both, and 42% neither. The size of group differences on key language and social communication measures was striking (2-3 standard deviations). Social communication deficits included autistic mannerisms and were associated with social, emotional and behavioural difficulties (SEBDs); in contrast, language impairment was associated with hyperactivity only. Children with both language and social communication problems had the most severe difficulties on all measures. These distinct school-age profiles emerged gradually. Investigation of developmental trajectories revealed that the three impaired groups did not differ significantly on language or SEBD measures when the children were first seen. Only low performance on the Early Sociocognitive Battery, a new measure of social responsiveness, joint attention and symbolic understanding, differentiated the children with and without social communication problems at 9-11 years. These findings suggest that some children who first present with language delay or difficulties have undetected Autism Spectrum Disorders which may or may not be accompanied by language impairment in the longer term. This new evidence of developmental trajectories starting in the preschool years throws further light on the nature of social communication and language problems in school-age children, relations between language impairment and SEBDs, and on the nature of early language development.

  3. The between-day reproducibility of fasting, satiety-related analytes, in 8 to 11year-old boys.

    PubMed

    Allsop, Susan; Rumbold, Penny L S; Green, Benjamin P

    2016-10-01

    The aim of the present study was to establish the between-day reproducibility of fasting plasma GLP-17-36, glucagon, leptin, insulin and glucose, in lean and overweight/obese 8-11year-old boys. A within-group study design was utilised wherein the boys attended two study days, separated by 1week, where a fasting fingertip capillary blood sample was obtained. Deming regression, mean difference, Bland-Altman limits of agreement (LOA) and typical imprecision as a percentage coefficient of variation (CV %), were utilised to assess reproducibility between-days. On a group level, Deming regression detected no evidence of systematic or proportional bias between-days for all of the satiety-related analytes however, only glucose and plasma GLP-17-36 displayed low typical and random imprecision. When analysed according to body composition, good reproducibility was maintained for glucose in the overweight/obese boys and for plasma GLP-17-36, in those with lean body mass. The present findings demonstrate that the measurement of glucose and plasma GLP-17-36 by fingertip capillary sampling on a group level, is reproducible between-days, in 8-11year-old boys. Comparison of blood glucose obtained by fingertip capillary sampling can be made between lean and overweight/obese 8-11year-old boys. Presently, the comparison of fasting plasma GLP-17-36 according to body weight is inappropriate due to high imprecision observed in lean boys between-days. The use of fingertip capillary sampling in the measurement of satiety-related analytes has the potential to provide a better understanding of mechanisms that affect appetite and feeding behaviour in children. PMID:27265877

  4. The between-day reproducibility of fasting, satiety-related analytes, in 8 to 11year-old boys.

    PubMed

    Allsop, Susan; Rumbold, Penny L S; Green, Benjamin P

    2016-10-01

    The aim of the present study was to establish the between-day reproducibility of fasting plasma GLP-17-36, glucagon, leptin, insulin and glucose, in lean and overweight/obese 8-11year-old boys. A within-group study design was utilised wherein the boys attended two study days, separated by 1week, where a fasting fingertip capillary blood sample was obtained. Deming regression, mean difference, Bland-Altman limits of agreement (LOA) and typical imprecision as a percentage coefficient of variation (CV %), were utilised to assess reproducibility between-days. On a group level, Deming regression detected no evidence of systematic or proportional bias between-days for all of the satiety-related analytes however, only glucose and plasma GLP-17-36 displayed low typical and random imprecision. When analysed according to body composition, good reproducibility was maintained for glucose in the overweight/obese boys and for plasma GLP-17-36, in those with lean body mass. The present findings demonstrate that the measurement of glucose and plasma GLP-17-36 by fingertip capillary sampling on a group level, is reproducible between-days, in 8-11year-old boys. Comparison of blood glucose obtained by fingertip capillary sampling can be made between lean and overweight/obese 8-11year-old boys. Presently, the comparison of fasting plasma GLP-17-36 according to body weight is inappropriate due to high imprecision observed in lean boys between-days. The use of fingertip capillary sampling in the measurement of satiety-related analytes has the potential to provide a better understanding of mechanisms that affect appetite and feeding behaviour in children.

  5. Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome.

    PubMed

    Mazerkina, Nadia; Trunin, Yuri; Gorelyshev, Sergey; Golanov, Andrey; Kadashev, Boris; Shishkina, Liudmila; Rotin, Daniil; Karmanov, Maxim; Orlova, Elizabet

    2016-02-01

    Thyrotropinomas (TSHomas) are rare pituitary adenomas, particularly in childhood. We present here the case of an 11-year-old boy with type 1 autoimmune polyglandular syndrome (APS1) and TSHoma which was diagnosed by elevated thyroid - stimulating hormone and thyroid hormones levels without evident clinical signs of hyperthyroidism. He was underwent partial resection of the tumor via transsphenoidal approach and subsequently radiation therapy. Consequently, 1 year after radiotherapy, the patient developed growth hormone deficiency, three and half years after radiation became euthyroid, and five and half years after treatment - hypothyroid. This is the first case of the coexistence of these two rare endocrine diseases in one patient. PMID:26244671

  6. Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

    PubMed Central

    Prosser, Suzanna L.; Samant, Mugdha D.; Baxter, Joanne E.; Morrison, Ciaran G.; Fry, Andrew M.

    2014-01-01

    Centrosome duplication is licensed by the disengagement, or ‘uncoupling’, of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature disengagement results from untimely activation of the APC/C leading to securin degradation and release of active separase. APC/C activation during G2 arrest is dependent on Plk1-mediated degradation of the APC/C inhibitor, Emi1, but Plk1 also has a second APC/C-independent role in promoting disengagement. Importantly, APC/C and Plk1 activity also stimulate centriole disengagement in response to hydroxyurea or DNA damage-induced cell cycle arrest and this leads to centrosome amplification. However, the re-duplication of disengaged centrioles is dependent on Cdk2 activity and Cdk2 activation coincides with a subsequent inactivation of the APC/C and re-accumulation of cyclin A. Release from these arrests leads to mitotic entry but, due to the presence of disengaged and/or amplified centrosomes, formation of abnormal mitotic spindles that lead to chromosome missegregation. Thus, oscillation of APC/C activity during cell cycle arrest promotes both centrosome amplification and genome instability. PMID:22956538

  7. The influence of sexual cycle on the MFO activity: A practical problem in biomonitoring

    SciTech Connect

    Fossi, C.; Leonzio, C.; Focardi, S. )

    1988-09-01

    During the last several years the induction of the mixed function oxidases system has been commonly used as a biochemical markers of xenobiotics contamination in aquatic, marine and terrestrial animals. The use of this index of stress in wild animals like birds has directly contributed to their ability to detect and understand the significance of the exposure to liphosoluble contaminants in the environment. Nevertheless, several intrinsic factors, such as for example the hormonal modulation during the sexual cycle, seems to significantly modify the activity of some monooxygenases. The aim of this paper is to underline, using three different examples of studies in wild birds exposed to PCBs, the role of the sexual cycles in the modification of MFO activity and consequently the importance of considering this aspect in planning biomonitoring.

  8. Integrated gasification combined-cycle research development and demonstration activities in the U.S.

    SciTech Connect

    Ness, H.M.

    1994-12-31

    The United States Department of Energy (DOE) has selected seven integrated gasification combined-cycle (IGCC) advanced power systems for demonstration in the Clean Coal Technology (CCT) Program. DOE`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D)program that supports the CCT program, and addresses long-term improvements in support of IGCC technology. This overview briefly describes the CCT projects and the supporting RD&D activities.

  9. Modifications in activation of lower limb muscles as a function of initial foot position in cycling.

    PubMed

    Padulo, Johnny; Powell, Douglas W; Ardigò, Luca P; Viggiano, Davide

    2015-08-01

    Cyclic movements, such as walking/cycling, require the activity of spinal-circuits, the central-pattern-generators (CPG). To our knowledge little work has been done to investigate the activation of these circuits, e.g., the muscular and kinematic activity during cycling initiation. This study aims to detail the muscle output properties as a function of the initial lower limb-position using a simple cycling paradigm. Therefore, subjects were required to pedal on a cycle-ergometer in seated position starting at different-crank-angles (0-150°). Surface-electromyography was recorded from the gluteus major (GL), vastus lateralis (VL), and gastrocnemius medialis (GM), while crank position was recorded using a linear-encoder. Gluteus major peak-activity (PA) occurred at 65.0±12.4° when starting with 0° initial crank position (ICP), while occurred maximally at 110.5±2.9 when starting with 70° ICP. Vastus lateralis PA occurred at 40.7±8.8° with 0° ICP, whereas with 70° ICP PA occurred at 103.4±4.0°. Similarly, GM PA occurred at 112.0±10.7° with 0° ICP, whereas with 70° ICP PA occurred at 142.5±4.2° PA. Gluteus major and gastrocnemius medialis showed similar PA phase shifts, which may suggest they are controlled by same local circuitry, in agreement with their common spinal origin, i.e., motoneurons pool in S1-S2.

  10. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest

    PubMed Central

    Granier, Celine J.; Wang, Wei; Tsang, Tiffany; Steward, Ruth; Sabaawy, Hatem E.; Bhaumik, Mantu; Rabson, Arnold B.

    2014-01-01

    ABSTRACT PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In order to better understand the functions of PDCD2 in mammalian development, we have examined PDCD2 activity in mouse blastocyst embryos, as well as in mouse embryonic stem cells (ESCs) and embryonic fibroblasts (MEFs). We have studied mice bearing a targeted PDCD2 locus functioning as a null allele through a splicing gene trap, or as a conditional knockout, by deletion of exon2 containing the MYND domain. Tamoxifen-induced knockout of PDCD2 in MEFs, as well as in ESCs, leads to defects in progression from the G1 to the S phase of cell cycle, associated with increased levels of p53 protein and p53 target genes. G1 prolongation in ESCs was not associated with induction of differentiation. Loss of entry into S phase of the cell cycle and marked induction of nuclear p53 were also observed in PDCD2 knockout blastocysts. These results demonstrate a unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse. PMID:25150276

  11. Regulation of Brain Activity in the Fusiform Face and Parahippocampal Place Areas in 7-11-Year-Old Children

    ERIC Educational Resources Information Center

    Vuontela, Virve; Jiang, Ping; Tokariev, Maksym; Savolainen, Petri; Ma, YuanYe; Aronen, Eeva T.; Fontell, Tuija; Liiri, Tiina; Ahlstrom, Matti; Salonen, Oili; Carlson, Synnove

    2013-01-01

    Developmental studies have demonstrated that cognitive processes such as attention, suppression of interference and memory develop throughout childhood and adolescence. However, little is currently known about the development of top-down control mechanisms and their influence on cognitive performance. In the present study, we used functional…

  12. [Epidemiological study of very preterm infants at Rouen University Hospital: changes in mortality, morbidity, and care over 11 years].

    PubMed

    Pinto Cardoso, G; Abily-Donval, L; Chadie, A; Guerrot, A-M; Pinquier, D; Marret, S

    2013-02-01

    The very preterm birth rate has increased in the past few years. Despite advances in neonatal medicine, neurodevelopmental sequelae have not decreased, despite a perinatal plan published in France in 1994. We conducted an epidemiological comparative survey at Rouen University Hospital in order to analyze morbidity, mortality, and care of very of premature infants by comparing the years 2000, 2005, and 2010. This hospital draws on an area of 17,000 births per year. Our survey was a single-center prospective, descriptive, and comparative study. The three cohorts had the same characteristics and the mortality rate was constant for 11 years. Use of medically assisted procreation and maternal age increased over this period. Chorioamnionitis halved, whereas duration of intrapartum antibiotic therapy increased. Neonatal morbidity was stable for hyaline membrane disease, bronchopulmonary dysplasia, maternofetal or nosocomial infections, and necrotizing enterocolitis. Regarding neurological complications, intraventricular hemorrhages decreased and white matter lesions remained constant. The rate of severe retinopathy remained low. The duration of parenteral nutrition and assisted ventilation, use of postnatal corticosteroids, and length of hospitalization decreased. The breastfeeding rate has increased since 2000 in parallel with postnatal growth restriction : 39% of the premature infants had a weight under the 10th percentile at hospital discharge. Our study allowed us to follow up the changes in neonatal epidemiological characteristics, the mortality and morbidity of extreme premature infants over a period of 11 years and showed few significant changes. Knowledge of medical practices is essential to improve the short- and long-term outcome of premature infants.

  13. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    PubMed Central

    Liu, Pengda; Begley, Michael; Michowski, Wojciech; Inuzuka, Hiroyuki; Ginzberg, Miriam; Gao, Daming; Tsou, Peiling; Gan, Wenjian; Papa, Antonella; Kim, Byeong Mo; Wan, Lixin; Singh, Amrik; Zhai, Bo; Yuan, Min; Wang, Zhiwei; Gygi, Steven P.; Lee, Tae Ho; Lu, Kun-Ping; Toker, Alex; Pandolfi, Pier Paolo; Asara, John M.; Kirschner, Marc W.; Sicinski, Piotr; Cantley, Lewis; Wei, Wenyi

    2014-01-01

    Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism. Akt hyperactivation contributes to many pathophysiological conditions, including human cancers1–3, and is closely associated with poor prognosis and chemo- or radio-therapeutic resistance4. Phosphorylation of Akt at S473 (ref. 5) and T308 (ref. 6) activates Akt. However, it remains unclear whether further mechanisms account for full Akt activation, and whether Akt hyperactivation is linked to misregulated cell cycle progression, another cancer hallmark7. Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression. Mechanistically, phosphorylation of S477 and T479 at the Akt extreme carboxy terminus by cyclin-dependent kinase 2 (Cdk2)/cyclin A or mTORC2, under distinct physiological conditions, promotes Akt activation through facilitating, or functionally compensating for, S473 phosphorylation. Furthermore, deletion of the cyclin A2 allele in the mouse olfactory bulb leads to reduced S477/T479 phosphorylation and elevated cellular apoptosis. Notably, cyclin A2-deletion-induced cellular apoptosis in mouse embryonic stem cells is partly rescued by S477D/T479E-Akt1, supporting a physiological role for cyclin A2 in governing Akt activation. Together, the results of our study show Akt S477/T479 phosphorylation to be an essential layer of the Akt activation mechanism to regulate its physiological functions, thereby providing a new mechanistic link between aberrant cell cycle progression and Akt hyperactivation in cancer. PMID:24670654

  14. Phototrophic biofilm activity and dynamics of diurnal Cd cycling in a freshwater stream.

    PubMed

    Beck, Aaron J; Janssen, Felix; Polerecky, Lubos; Herlory, Olivier; De Beer, Dirk

    2009-10-01

    Diel cycles of dissolved cationic metal concentrations commonly occur in freshwater streams in apparent response to coincident cycles in water quality parameters (pH, O2, temperature). Hourly sampling of the Cd-contaminated Riou Mort (France) revealed large diel cycles in "total" dissolved Cd (232-357 nM; < 0.45 microm) and "truly" dissolved Cd (56-297 nM; < 0.02 microm) which were strongly correlated with changes in water pH. Using measured fluxes, a dissolved O2 model was constructed that indicated that benthic metabolic activities, respiration and photosynthesis, were responsible for the diel O2 (and thus, CO2 and pH) variation in the stream. However, microsensor measurements also showed that the pH changes occurred at the biofilm interface earlier than in the bulk water column. This difference in timing was reflected in the Cd dynamics, where pH-controlled sorption effects caused Cd partitioning from the truly dissolved pool onto the biofilm in the morning, and from the truly dissolved pool onto large colloids (0.02-0.45 microm) later in the day. Because this process causes large changes in the bioavailable Cd fraction, it has significant implications for Cd toxicity in freshwater streams. This study demonstrates the profound control of benthic microbiological processes on the cycling of heavy metals in aquatic systems.

  15. Relationships between muscle activity and autonomic regulation during cycling with a torque-assisted bicycle.

    PubMed

    Kiryu, Tohru; Yamagata, Jun

    2006-01-01

    For customizing the assistance scheme of a torque-assisted bicycle, we estimated physical activity during cycling with ECG and surface EMG for the circuit including a steep uphill section near the middle and compared it with the vehicle data. Using the respiratory-sinus-arrhythmia-related power ratio in the fluctuation of the R-R interval, prRSA and a muscular fatigue index, we classified physical activity into four groups for each trial. Results showed that the assist enlarged prRSA but did not sufficiently support muscular fatigue.

  16. Statistical analysis of interplanetary shock waves observed during a complete solar activity cycle

    NASA Technical Reports Server (NTRS)

    Khalisi, E.; Schwenn, R.

    1995-01-01

    During the Helios mission a total of 391 fast forward non-corotating interplanetary shock waves was identified. For most of the 12 years between 1974 and 1986 unique shock detection was possible for more than 80 % of the time. The occurrence rate (in shocks per day) varied from 0.02 at activity minimum in 1976 to 0.17 in 1979 and 0.22 in 1982 with a significant drop to 0.13 in 1980, i.e. right at activity maximum. The average properties of all events as functions of solar distance. phase in the solar cycle, heliographic and -magnetic latitude and others are discussed.

  17. Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells.

    PubMed

    Klausen, Thomas Kjaer; Bergdahl, Andreas; Hougaard, Charlotte; Christophersen, Palle; Pedersen, Stine F; Hoffmann, Else K

    2007-03-01

    Recent evidence implicates the volume-regulated anion current (VRAC) and other anion currents in control or modulation of cell cycle progression; however, the precise involvement of anion channels in this process is unclear. Here, Cl- currents in Ehrlich Lettre Ascites (ELA) cells were monitored during cell cycle progression, under three conditions: (i) after osmotic swelling (i.e., VRAC), (ii) after an increase in the free intracellular Ca2+ concentration (i.e., the Ca2+-activated Cl- current, CaCC), and (iii) under steady-state isotonic conditions. The maximal swelling-activated VRAC current decreased in G1 and increased in early S phase, compared to that in G0. The isotonic steady-state current, which seems to be predominantly VRAC, also decreased in G1, and increased again in early S phase, to a level similar to that in G0. In contrast, the maximal CaCC current (500 nM free Ca2+ in the pipette), was unaltered from G0 to G1, but decreased in early S phase. A novel high-affinity anion channel inhibitor, the acidic di-aryl-urea NS3728, which inhibited both VRAC and CaCC, attenuated ELA cell growth, suggesting a possible mechanistic link between cell cycle progression and cell cycle-dependent changes in the capacity for conductive Cl- transport. It is suggested that in ELA cells, entrance into the S phase requires an increase in VRAC activity and/or an increased potential for regulatory volume decrease (RVD), and at the same time a decrease in CaCC magnitude. PMID:17111356

  18. Adenovirus type 2 activates cell cycle-dependent genes that are a subset of those activated by serum.

    PubMed Central

    Liu, H T; Baserga, R; Mercer, W E

    1985-01-01

    We have studied a panel of 10 genes and cDNA sequences that are expressed in a cell cycle-dependent manner in different types of cells from different species and that are inducible by different mitogens. These include five sequences (c-myc, 4F1, 2F1, 2A9, and KC-1) that are preferentially expressed in the early part of the G1 phase, three genes (ornithine decarboxylase, p53, and c-rasHa) preferentially expressed in middle or late G1, and two genes (thymidine kinase and histone H3) preferentially expressed in the S phase of the cell cycle. We have studied the expression of these genes in nonpermissive (tsAF8) and semipermissive (Swiss 3T3) cells infected with adenovirus type 2. Under the conditions of these experiments, adenovirus type 2 infection stimulates cellular DNA synthesis in both tsAF8 and 3T3 cells. However, four of the five early G1 genes (c-myc, 4F1, KC-1, and 2A9) and one of the late G1 genes (c-ras) are not induced by adenovirus infection, although they are strongly induced by serum. The other sequences (2F1, ornithine decarboxylase, p53, thymidine kinase, and histone H3) are activated by both adenovirus and serum. We conclude that the cell cycle-dependent genes activated by adenovirus 2 are a subset of the cell cycle-dependent genes activated by serum. The data suggest that the mechanisms by which serum and adenovirus induce cellular DNA synthesis are not identical. Images PMID:2427924

  19. Infection with Trypanosoma cruzi TcII and TcI in free-ranging population of lion tamarins (Leontopithecus spp): an 11-year follow-up

    PubMed Central

    Lisboa, Cristiane Varella; Monteiro, Rafael Veríssimo; Martins, Andreia Fonseca; Xavier, Samantha Cristina das Chagas; Lima, Valdirene dos Santos; Jansen, Ana Maria

    2015-01-01

    Here, we present a review of the dataset resulting from the 11-years follow-up of Trypanosoma cruzi infection in free-ranging populations of Leontopithecus rosalia (golden lion tamarin) and Leontopithecus chrysomelas (golden-headed lion tamarin) from distinct forest fragments in Atlantic Coastal Rainforest. Additionally, we present new data regarding T. cruzi infection of small mammals (rodents and marsupials) that live in the same areas as golden lion tamarins and characterisation at discrete typing unit (DTU) level of 77 of these isolates. DTU TcII was found to exclusively infect primates, while TcI infected Didelphis aurita and lion tamarins. The majority of T. cruzi isolates derived from L. rosalia were shown to be TcII (33 out 42) Nine T. cruzi isolates displayed a TcI profile. Golden-headed lion tamarins demonstrated to be excellent reservoirs of TcII, as 24 of 26 T. cruzi isolates exhibited the TcII profile. We concluded the following: (i) the transmission cycle of T. cruzi in a same host species and forest fragment is modified over time, (ii) the infectivity competence of the golden lion tamarin population fluctuates in waves that peak every other year and (iii) both golden and golden-headed lion tamarins are able to maintain long-lasting infections by TcII and TcI. PMID:25946156

  20. Infection with Trypanosoma cruzi TcII and TcI in free-ranging population of lion tamarins (Leontopithecus spp): an 11-year follow-up.

    PubMed

    Lisboa, Cristiane Varella; Monteiro, Rafael Veríssimo; Martins, Andreia Fonseca; Xavier, Samantha Cristina das Chagas; Lima, Valdirene Dos Santos; Jansen, Ana Maria

    2015-05-01

    Here, we present a review of the dataset resulting from the 11-years follow-up of Trypanosoma cruzi infection in free-ranging populations of Leontopithecus rosalia (golden lion tamarin) and Leontopithecus chrysomelas (golden-headed lion tamarin) from distinct forest fragments in Atlantic Coastal Rainforest. Additionally, we present new data regarding T. cruzi infection of small mammals (rodents and marsupials) that live in the same areas as golden lion tamarins and characterisation at discrete typing unit (DTU) level of 77 of these isolates. DTU TcII was found to exclusively infect primates, while TcI infected Didelphis aurita and lion tamarins. The majority of T. cruzi isolates derived from L. rosalia were shown to be TcII (33 out 42) Nine T. cruzi isolates displayed a TcI profile. Golden-headed lion tamarins demonstrated to be excellent reservoirs of TcII, as 24 of 26 T. cruzi isolates exhibited the TcII profile. We concluded the following: (i) the transmission cycle of T. cruzi in a same host species and forest fragment is modified over time, (ii) the infectivity competence of the golden lion tamarin population fluctuates in waves that peak every other year and (iii) both golden and golden-headed lion tamarins are able to maintain long-lasting infections by TcII and TcI.

  1. Stellar activity as noise in exoplanet detection - I. Methods and application to solar-like stars and activity cycles

    NASA Astrophysics Data System (ADS)

    Korhonen, H.; Andersen, J. M.; Piskunov, N.; Hackman, T.; Juncher, D.; Järvinen, S. P.; Jørgensen, U. G.

    2015-04-01

    The detection of exoplanets using any method is prone to confusion due to the intrinsic variability of the host star. We investigate the effect of cool starspots on the detectability of the exoplanets around solar-like stars using the radial velocity method. For investigating this activity-caused `jitter' we calculate synthetic spectra using radiative transfer, known stellar atomic and molecular lines, different surface spot configurations and an added planetary signal. Here, the methods are described in detail, tested and compared to previously published studies. The methods are also applied to investigate the activity jitter in old and young solar-like stars, and over a solar-like activity cycles. We find that the mean full jitter amplitude obtained from the spot surfaces mimicking the solar activity varies during the cycle approximately between 1 and 9 m s-1. With a realistic observing frequency a Neptune-mass planet on a 1-yr orbit can be reliably recovered. On the other hand, the recovery of an Earth-mass planet on a similar orbit is not feasible with high significance. The methods developed in this study have a great potential for doing statistical studies of planet detectability, and also for investigating the effect of stellar activity on recovered planetary parameters.

  2. Wrist activity in a woman: daily, weekly, menstrual, lunar, annual cycles?

    PubMed

    Binkley, S

    1992-09-01

    Wrist activity was monitored continuously for one year in a woman who went about her normal life. The year of data were analyzed for changes and rhythms--daily, weekly, menstrual, lunar, annual. For each day, average motions/5 minutes, activity onset, activity offset, alpha (duration of activity), and acrophase were measured. Periodograms and average daily wave forms were calculated. Well-defined, entrained, daily rest-activity cycles were observed throughout the year with periods close to 24 hours. There was weekend delay (0.7 hours) in onset, weekend decrease in alpha (1.0 hours), and weekend advance of acrophase (0.4 hours). Motions/5 minutes decreased 9%, onsets were 0.3 hours later, and alphas were 0.4 hours shorter on menstrual cycle days 8 through 18 which should have encompassed the time of ovulation. Lunar phase had no effect. Annual changes in onset (1.1 hours), offset (1.2 hours), and acrophase (1.1 hours) were attributed to the 1-hour change between standard and daylight savings time.

  3. Evaluation of Active Working Fluids for Brayton Cycles in Space Applications

    NASA Astrophysics Data System (ADS)

    Conklin, J. C.; Courville, G. E.; Scott, J. H.

    2004-02-01

    The main parameter of interest for space thermal power conversion to electricity is specific power, defined as the total electric power output per unit of system mass, rather than the cycle thermal efficiency. For a closed Brayton cycle, performance with two active working fluids, nitrogen tetroxide and aluminum chloride, is compared to that with an inert mixture of helium and xenon having a molecular mass of 40. A chemically active working fluid is defined here as a chemical compound that has a relatively high molecular weight at temperatures appropriate for the compressor inlet and dissociates to a lighter molecular weight fluid at typical turbine inlet temperatures. The active working fluids may have the advantage of a higher net turbomachinery work output and an advantageous enhancement of the heat transfer coefficient in the heat exchangers. The fundamental theory of the active working fluid concept is presented to demonstrate these potential advantages. Scoping calculations of the heat exchanger mass for a selected spacecraft application of 36.4 kW of electrical power output show that the nitrogen tetroxide active working fluid has an advantageous 7% to 30% lower mass-to-power ratio than that for the inert noble gas mixture, depending on the allowable turbine inlet temperature. The calculations for the aluminum chloride system suggest only a slight improvement in performance relative to the inert noble gas mixture.

  4. Evolution of sunspot activity and inversion of the Sun's polar magnetic field in the current cycle

    NASA Astrophysics Data System (ADS)

    Mordvinov, A. V.; Grigoryev, V. M.; Erofeev, D. V.

    2015-06-01

    A spatiotemporal analysis of the Sun's magnetic field was carried out to study the polar-field inversion in the current cycle in relation to sunspot activity. The causal relationship between these phenomena was demonstrated in a time-latitude aspect. After decay of long-lived activity complexes their magnetic fields were redistributed into the surrounding photosphere and formed unipolar magnetic regions which were transported to high latitudes. Zones of intense sunspot activity during 2011/2012 produced unipolar magnetic regions of the following polarities, whose poleward drift led to the inversion of the Sun's polar fields at the North and South Poles. At the North Pole the polar field reversal was completed by May 2013. It was demonstrated that mixed magnetic polarities near the North Pole resulted from violations of Joy's law at lower latitudes. Later sunspot activity in the southern hemisphere has led to a delay in magnetic polarity reversal at the South Pole. Thus, the north-south asymmetry of sunspot activity resulted in asynchronous polar field reversal in the current cycle.

  5. Discovery of HDAC Inhibitors with Potent Activity Against Multiple Malaria Parasite Life Cycle Stages

    PubMed Central

    Hansen, Finn K.; Sumanadasa, Subathdrage D. M.; Stenzel, Katharina; Duffy, Sandra; Meister, Stephan; Marek, Linda; Schmetter, Rebekka; Kuna, Krystina; Hamacher, Alexandra; Mordmüller, Benjamin; Kassack, Matthias U.; Winzeler, Elizabeth A.; Avery, Vicky M.; Andrews, Katherine T.; Kurz, Thomas

    2015-01-01

    In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel and specific inhibitor of human HDAC4 and 5, was used as a starting point to rapidly construct a mini-library of HDAC inhibitors using a straightforward solid-phase supported synthesis. Several of these novel HDAC inhibitors were found to have potent in vitro activity against asexual stage P. falciparum malaria parasites. Representative compounds were shown to hyperacetylate P. falciparum histones and to inhibit deacetylase activity of recombinant PfHDAC1 and P. falciparum nuclear extracts. All compounds were also screened in vitro for activity against P. berghei exo-erythrocytic stages and selected compounds were further tested against late stage (IV and V) P. falciparum gametocytes. Of note, some compounds showed nanomolar activity against all three life cycle stages tested (asexual, exo-erythrocytic and gametocyte stages) and several compounds displayed significantly increased parasite selectivity compared to the reference HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). These data suggest that it may be possible to develop HDAC inhibitors that target multiple malaria parasite life cycle stages. PMID:24904967

  6. Instantaneous quantification of skeletal muscle activation, power production, and fatigue during cycle ergometry.

    PubMed

    Coelho, A C; Cannon, D T; Cao, R; Porszasz, J; Casaburi, R; Knorst, M M; Rossiter, H B

    2015-03-01

    A rapid switch from hyperbolic to isokinetic cycling allows the velocity-specific decline in maximal power to be measured, i.e., fatigue. We reasoned that, should the baseline relationship between isokinetic power (Piso) and electromyography (EMG) be reproducible, then contributions to fatigue may be isolated from 1) the decline in muscle activation (muscle activation fatigue); and 2) the decline in Piso at a given activation (muscle fatigue). We hypothesized that the EMG-Piso relationship is linear, velocity dependent, and reliable for instantaneous fatigue assessment at intolerance during and following whole body exercise. Healthy participants (n = 13) completed short (5 s) variable-effort isokinetic bouts at 50, 70, and 100 rpm to characterize baseline EMG-Piso. Repeated ramp incremental exercise tests were terminated with maximal isokinetic cycling (5 s) at 70 rpm. Individual baseline EMG-Piso relationships were linear (r(2) = 0.95 ± 0.04) and velocity dependent (analysis of covariance). Piso at intolerance (two legs, 335 ± 88 W) was ∼45% less than baseline [630 ± 156 W, confidence interval of the difference (CIDifference) 211, 380 W, P < 0.05]. Following intolerance, Piso recovered rapidly (F = 44.1; P < 0.05; η(2) = 0.79): power was reduced (P < 0.05) vs. baseline only at 0-min (CIDifference 80, 201 W) and 1-min recovery (CIDifference 13, 80 W). Activation fatigue and muscle fatigue (one leg) were 97 ± 55 and 60 ± 50 W, respectively. Mean bias ± limits of agreement for reproducibility were as follows: baseline Piso 1 ± 30 W; Piso at 0-min recovery 3 ± 35 W; and EMG at Piso 3 ± 14%. EMG power is linear, velocity dependent, and reproducible. Deviation from this relationship at the limit of tolerance can quantify the "activation" and "muscle" related components of fatigue during cycling.

  7. Life cycle of the tick Ixodes uriae in penguin colonies: relationships with host breeding activity.

    PubMed

    Frenot, Y; de Oliveira, E; Gauthier-Clerc, M; Deunff, J; Bellido, A; Vernon, P

    2001-08-01

    A survey of the temporal pattern of population structure and feeding activity of the seabird tick Ixodes uriae was conducted for the first time in two host species colonies: King penguin (Aptenodytes patagonicus halli) and Macaroni penguin (Eudyptes chrysolophus chrysolophus). The life cycle of the tick was investigated over 3 years in a King penguin colony and 2 years in a Macaroni penguin colony at Possession Island (Crozet Archipelago). There was a marked seasonal feeding activity pattern of ticks in both host species, connected with the presence of birds during the breeding season. Although the King penguin colonies were occupied throughout the year by birds, the favourable period for engorgement was limited to 3.5-4.5 months, and almost all the ticks overwintered in the unengorged state. Consequently, I. uriae probably completed its life cycle over 3 years in King penguin colonies. In contrast, this life cycle could be shortened to 2 years in Macaroni penguin colonies, as a result of a different timetable of the presence of birds for breeding and moulting. The relationships between such plasticity and the host behaviour and subantarctic climatic conditions are discussed. PMID:11429167

  8. Life cycle of the tick Ixodes uriae in penguin colonies: relationships with host breeding activity.

    PubMed

    Frenot, Y; de Oliveira, E; Gauthier-Clerc, M; Deunff, J; Bellido, A; Vernon, P

    2001-08-01

    A survey of the temporal pattern of population structure and feeding activity of the seabird tick Ixodes uriae was conducted for the first time in two host species colonies: King penguin (Aptenodytes patagonicus halli) and Macaroni penguin (Eudyptes chrysolophus chrysolophus). The life cycle of the tick was investigated over 3 years in a King penguin colony and 2 years in a Macaroni penguin colony at Possession Island (Crozet Archipelago). There was a marked seasonal feeding activity pattern of ticks in both host species, connected with the presence of birds during the breeding season. Although the King penguin colonies were occupied throughout the year by birds, the favourable period for engorgement was limited to 3.5-4.5 months, and almost all the ticks overwintered in the unengorged state. Consequently, I. uriae probably completed its life cycle over 3 years in King penguin colonies. In contrast, this life cycle could be shortened to 2 years in Macaroni penguin colonies, as a result of a different timetable of the presence of birds for breeding and moulting. The relationships between such plasticity and the host behaviour and subantarctic climatic conditions are discussed.

  9. Sub- and Quasi-Centurial Cycles in Solar and Geomagnetic Activity Data Series

    NASA Astrophysics Data System (ADS)

    Komitov, B.; Sello, S.; Duchlev, P.; Dechev, M.; Penev, K.; Koleva, K.

    2016-07-01

    The subject of this paper is the existence and stability of solar cycles with durations in the range of 20-250 years. Five types of data series are used: 1) the Zurich series (1749-2009 AD), the mean annual International sunspot number Ri, 2) the Group sunspot number series Rh (1610-1995 AD), 3) the simulated extended sunspot number from Extended time series of Solar Activity Indices (ESAI) (1090-2002 AD), 4) the simulated extended geomagnetic aa-index from ESAI (1099-2002 AD), 5) the Meudon filament series (1919-1991 AD). Two principally independent methods of time series analysis are used: the T-R periodogram analysis (both in standard and ``scanning window'' regimes) and the wavelet-analysis. The obtained results are very similar. A strong cycle with a mean duration of 55-60 years is found to exist in all series. On the other hand, a strong and stable quasi 110-120 years and ˜200-year cycles are obtained in all of these series except in the Ri one. The high importance of the long term solar activity dynamics for the aims of solar dynamo modeling and predictions is especially noted.

  10. Development of 23 Cycles Activity in Northern and Southern Hemispheres of the Sun

    NASA Astrophysics Data System (ADS)

    Ryabov, M. I.; Sukharev, A. L.; Lukashuk, S. A.

    On an example of the 23rd cycle of solar activity the basic properties of its development in northern and southern hemispheres were researched (daily values of Wolf Sunspot Number - W, the daily values of Sun spots areas - Sp and daily values of flare index - FI.) Effects of application of full-scale Wavelet analysis for studying the temporary structure of formation of a solar cycle show the difference in northern and southern hemispheres. The "leading" periods (in northern hemisphere - 340 days, and in southern hemisphere - 709 days) differ. Thus, the activity period in two years is predominate in southern hemisphere. The "leading" period for the flare index for northern hemisphere is 555 days, and for southern hemisphere is 709 days. In general the basic periods W in northern hemisphere are in the range of 37-555 days, and in southern - 78-906 days, SpN (61-906 days), SpS (61-1477 days), FIN (37-555 days), FIS (23-709 days), FIS - (14709 days) depending on the phase of solar cycle.

  11. Comparison of solar activity during last two minima on turn of Activity Cycles 22/23 and 23/24

    NASA Astrophysics Data System (ADS)

    Gryciuk, Magdalena; Gburek, Szymon; Siarkowski, Marek; Podgorski, Piotr; Sylwester, Janusz; Farnik, Frantisek

    2013-07-01

    The subject of our work is the review and comparison of solar activity during the last two solar minima that occurred between recent activity cycles. We use the soft X-ray global solar corona observations covering the two nine-months long time intervals in 1997/98 and 2009. Data from RF15-I multichannel photometer are used for the penultimate minimum. For the last unusually deep and prolonged solar activity minimum in 2009 the data from SphinX spectrophotometer are used. Comparison of measurements from both minima takes place in the overlapping energy range 2-15 keV. We focus on the active region formation, evolution and flaring productivity during respective minima.

  12. Background solar velocity spectrum at high and low phases of solar activity cycle

    NASA Astrophysics Data System (ADS)

    Régulo, C.; Roca Cortés, T.; Vázquez Ramió, H.

    2002-12-01

    Using GOLF/SOHO data a detailed analysis of the solar background spectrum has been performed at high and low phases of solar activity cycle. The analysis includes not only the non-periodic components of the background power spectrum but also the periodic ones. Apart from the solar activity, other causes produce similar effects in the data, particularly the different depths in the solar atmosphere where the measurements are done, because due to the sun-satellite relative velocity, we are observing at different positions in the line profile. Another effect is that different line wings are used in the observation at two different epochs, before and after SOHO loss and recovery which, unfortunately, coincide with minimum and maximum of solar activity. In this work we have tried to separate all these effects in order to really understand what is being seen in the data and ultimately extract the effects of solar activity on the acoustic background solar spectrum.

  13. Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes

    SciTech Connect

    Fyrberg, Anna; Albertioni, Freidoun; Lotfi, Kourosh . E-mail: koulo@imv.liu.se

    2007-06-15

    Deoxynucleoside analogues (dNAs) are cytotoxic towards both replicating and indolent malignancies. The impact of fluctuations in the metabolism of dNAs in relation to cell cycle could have strong implications regarding the activity of dNAs. Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) are important enzymes for phosphorylation/activation of dNAs. These drugs can be dephosphorylated/deactivated by 5'-nucleotidases (5'-NTs) and elevated activities of 5'-NTs and decreased dCK and/or dGK activities represent resistance mechanisms towards dNAs. The activities of dCK, dGK, and three 5'-NTs were investigated in four human leukemic cell lines in relationship to cell cycle progression and cytotoxicity of dNAs. Synchronization of cell cultures to arrest in G0/G1 by serum-deprivation was performed followed by serum-supplementation for cell cycle progression. The activities of dCK and dGK increased up to 3-fold in CEM, HL60, and MOLT-4 cells as they started to proliferate, while the activity of cytosolic nucleotidase I was reduced in proliferating cells. CEM, HL60, and MOLT-4 cells were also more sensitive to cladribine, cytarabine, 9-{beta}-D-arabinofuranosylguanine and clofarabine than K562 cells which demonstrated lower levels and less alteration of these enzymes and were least susceptible to the cytotoxic effects of most dNAs. The results suggest that, in the cell lines studied, the proliferation process is associated with a general shift in the direction of activation of dNAs by inducing activities of dCK/dGK and reducing the activity of cN-I which is favourable for the cytotoxic effects of cladribine, cytarabine and, 9-{beta}-D-arabinofuranosylguanine. These results emphasize the importance of cellular proliferation and dNA metabolism by both phosphorylation and dephosphorylation for susceptibility to dNAs. It underscores the need to understand the mechanisms of action and resistance to dNAs in order to increase efficacy of dNAs treatment by new rational.

  14. Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition.

    PubMed

    Reitz, M U; Gifford, M L; Schäfer, P

    2015-04-01

    Biotic stress and diseases caused by pathogen attack pose threats in crop production and significantly reduce crop yields. Enhancing immunity against pathogens is therefore of outstanding importance in crop breeding. However, this must be balanced, as immune activation inhibits plant growth. This immunity-coupled growth trade-off does not support resistance but is postulated to reflect the reallocation of resources to drive immunity. There is, however, increasing evidence that growth-immunity trade-offs are based on the reconfiguration of hormone pathways, shared by growth and immunity signalling. Studies in roots revealed the role of hormones in orchestrating growth across different cell types, with some hormones showing a defined cell type-specific activity. This is apparently highly relevant for the regulation of the cell cycle machinery and might be part of the growth-immunity cross-talk. Since plants are constantly exposed to Immuno-activating microbes under agricultural conditions, the transition from a growth to an immunity operating mode can significantly reduce crop yield and can conflict our efforts to generate next-generation crops with improved yield under climate change conditions. By focusing on roots, we outline the current knowledge of hormone signalling on the cell cycle machinery to explain growth trade-offs induced by immunity. By referring to abiotic stress studies, we further introduce how root cell type-specific hormone activities might contribute to growth under immunity and discuss the feasibility of uncoupling the growth-immunity cross-talk.

  15. Observations of hysteresis in solar cycle variations among seven solar activity indicators

    NASA Technical Reports Server (NTRS)

    Bachmann, Kurt T.; White, Oran R.

    1994-01-01

    We show that smoothed time series of 7 indices of solar activity exhibit significant solar cycle dependent differences in their relative variations during the past 20 years. In some cases these observed hysteresis patterns start to repeat over more than one solar cycle, giving evidence that this is a normal feature of solar variability. Among the indices we study, we find that the hysteresis effects are approximately simple phase shifts, and we quantify these phase shifts in terms of lag times behind the leading index, the International Sunspot Number. Our measured lag times range from less than one month to greater than four months and can be much larger than lag times estimated from short-term variations of these same activity indices during the emergence and decay of major active regions. We argue that hysteresis represents a real delay in the onset and decline of solar activity and is an important clue in the search for physical processes responsible for changing solar emission at various wavelengths.

  16. Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition

    PubMed Central

    Reitz, M. U.; Gifford, M. L.; Schäfer, P.

    2015-01-01

    Biotic stress and diseases caused by pathogen attack pose threats in crop production and significantly reduce crop yields. Enhancing immunity against pathogens is therefore of outstanding importance in crop breeding. However, this must be balanced, as immune activation inhibits plant growth. This immunity-coupled growth trade-off does not support resistance but is postulated to reflect the reallocation of resources to drive immunity. There is, however, increasing evidence that growth–immunity trade-offs are based on the reconfiguration of hormone pathways, shared by growth and immunity signalling. Studies in roots revealed the role of hormones in orchestrating growth across different cell types, with some hormones showing a defined cell type-specific activity. This is apparently highly relevant for the regulation of the cell cycle machinery and might be part of the growth–immunity cross-talk. Since plants are constantly exposed to Immuno-activating microbes under agricultural conditions, the transition from a growth to an immunity operating mode can significantly reduce crop yield and can conflict our efforts to generate next-generation crops with improved yield under climate change conditions. By focusing on roots, we outline the current knowledge of hormone signalling on the cell cycle machinery to explain growth trade-offs induced by immunity. By referring to abiotic stress studies, we further introduce how root cell type-specific hormone activities might contribute to growth under immunity and discuss the feasibility of uncoupling the growth–immunity cross-talk. PMID:25821072

  17. Effect of sprouting and light cycle on antioxidant activity of Brassica oleracea varieties.

    PubMed

    Vale, Ana Paula; Cidade, Honorina; Pinto, Madalena; Oliveira, M Beatriz P P

    2014-12-15

    The antioxidant activity of sprouts from four Brassica oleracea varieties was evaluated using "in vitro" methods (total phenolic and flavonoid content; radical scavenging assays: DPPH, hydroxyl and peroxyl; and Ferrous Ion-chelating Ability Assay). Light cycles and sprouting influenced the potential antioxidant activity of sprouts and significant differences were observed between varieties. Generally, antioxidant activity decreased with sprouting and increased in the presence of light, whose discriminant effect was highly significant (P<0.001). Red cabbage sprouts produced under light cycles showed the highest antioxidant activity (57.11 μg mL(-1) Ferrous Ion-chelating Ability, 221.46 μg mL(-1) Hydroxyl radical scavenging, 279.02 μg mL(-1) Peroxyl radical scavenging). Among the traditional Portuguese brassica varieties, Penca cabbage sprouts produced under light presented higher antioxidant capacity, and also higher phenolic and flavonoid content (54.04 mg GAEg(-1) d.w. extract and 21.33 QEg(-1) d.w. extract, respectively) than Galega kale. The phenolic content of Brassica sprouts had a significant contribution to the antioxidant capacity.

  18. Dynamo-based scheme for forecasting the magnitude of solar activity cycles

    NASA Technical Reports Server (NTRS)

    Layden, A. C.; Fox, P. A.; Howard, J. M.; Sarajedini, A.; Schatten, K. H.

    1991-01-01

    This paper presents a general framework for forecasting the smoothed maximum level of solar activity in a given cycle, based on a simple understanding of the solar dynamo. This type of forecasting requires knowledge of the sun's polar magnetic field strength at the preceding activity minimum. Because direct measurements of this quantity are difficult to obtain, the quality of a number of proxy indicators already used by other authors is evaluated, which are physically related to the sun's polar field. These indicators are subjected to a rigorous statistical analysis, and the analysis technique for each indicator is specified in detail in order to simplify and systematize reanalysis for future use. It is found that several of these proxies are in fact poorly correlated or uncorrelated with solar activity, and thus are of little value for predicting activity maxima. Also presented is a scheme in which the predictions of the individual proxies are combined via an appropriately weighted mean to produce a compound prediction. The scheme is then applied to the current cycle 22, and a maximum smoothed international sunspot number of 171 + or - 26 is estimated.

  19. Enriching step-based product information models to support product life-cycle activities

    NASA Astrophysics Data System (ADS)

    Sarigecili, Mehmet Ilteris

    The representation and management of product information in its life-cycle requires standardized data exchange protocols. Standard for Exchange of Product Model Data (STEP) is such a standard that has been used widely by the industries. Even though STEP-based product models are well defined and syntactically correct, populating product data according to these models is not easy because they are too big and disorganized. Data exchange specifications (DEXs) and templates provide re-organized information models required in data exchange of specific activities for various businesses. DEXs show us it would be possible to organize STEP-based product models in order to support different engineering activities at various stages of product life-cycle. In this study, STEP-based models are enriched and organized to support two engineering activities: materials information declaration and tolerance analysis. Due to new environmental regulations, the substance and materials information in products have to be screened closely by manufacturing industries. This requires a fast, unambiguous and complete product information exchange between the members of a supply chain. Tolerance analysis activity, on the other hand, is used to verify the functional requirements of an assembly considering the worst case (i.e., maximum and minimum) conditions for the part/assembly dimensions. Another issue with STEP-based product models is that the semantics of product data are represented implicitly. Hence, it is difficult to interpret the semantics of data for different product life-cycle phases for various application domains. OntoSTEP, developed at NIST, provides semantically enriched product models in OWL. In this thesis, we would like to present how to interpret the GD & T specifications in STEP for tolerance analysis by utilizing OntoSTEP.

  20. The Effects of Radiatively Active Water Ice Clouds on the Martian Global Seasonal Water Cycle

    NASA Astrophysics Data System (ADS)

    Haberle, Robert M.; Montmessin, F.; Kahre, M. A.; Hollingsworth, J. L.; Schaeffer, J.; de Brouchoven de Bergeyck, A.; Wilson, J.

    2010-10-01

    Recently, Mars General Circulation Models (MGCM) have begun implementing cloud microphysics packages to better account for their role in the water cycle. Here, we discuss the importance of their radiative effects. For the past several years we have been implementing and testing a state-of-the-art cloud microphysics package into the NASA/Ames MGCM. This package accounts for the nucleation, growth, transport, and settling of a size distribution water ice cloud particles in a self-consistent fashion. The model also has flags to activate their solar and infrared radiative effects, which depend on the size and dust content of the ice particles. We have performed two simulations of the global water cycle on Mars: one in which the clouds are radiatively inert, and one in which they are radiatively active. We find that the thermal structure of the atmosphere in the radiatively active cloud run compares better with MGS TES and MRO MCS data. However, the water cycle dries out considerably with radiatively active clouds. There are several reasons for this but the main reason appears to be related to a cooling of the North Polar Residual Cap (NPRC) in the model that is brought about by the reflective nature of the clouds that develop in the lower atmosphere immediately above the NPRC. These clouds increase the planetary albedo at these latitudes and reduce the solar flux at the surface, which is not sufficiently compensated for by an increase in downward infrared emission. Our conclusion at this point, based upon comparison with MRO MCS and MARCI data, is that the model is overpredicting the cloud fields in the vicinity of the NPRC.

  1. Echocardiographic Diagnosis of Incidentally Found Left Coronary Artery to Pulmonary Artery Fistula in an 11-Year-Old Girl

    PubMed Central

    Chen, Bo-Hau; Lin, Chu-Chuan; Weng, Ken-Pen; Wu, Huang-Wei; Chien, Jen-Hung; Huang, Shih-Ming

    2016-01-01

    We report on a healthy 11-year-old girl who presented to our facility with sudden onset of fainting in a strenuous running course. Transthoracic echocardiography at short-axis view showed a diastolic flow into the main pulmonary artery (PA). The diagnosis of left anterior descending artery (LAD) to PA fistula was documented by cardiac computed tomography and catheterization. Interventional therapy of LAD to the main PA fistula was not performed because of no evidence of myocardial ischemia or significant hemodynamic change. Presently, the patient remains asymptomatic. Coronary fistula with an incidence of about 0.1-0.8% is very rare and may be undetected, particularly in pediatric patients without cardiac murmur. We herein describe the diagnostic approach and discuss the current treatment modalities. PMID:27274178

  2. Prosthodontic Rehabilitation of Hereditary Ectodermal Dysplasia in an 11-Year-Old Patient with Flexible Denture: A Case Report

    PubMed Central

    Jain, Neha; Naitam, Dinesh; Wadkar, Arti; Nemane, Anuradha; Katoch, Shiva; Dewangan, Ashish

    2012-01-01

    Hereditary ectodermal dysplasia is a rare group of inherited disorders characterized by aplasia or dysplasia of two or more tissues of ectodermal origin such as hair, nails, teeth, and skin. The dental characteristics of this syndrome include anodontia or hypodontia of the primary and/or permanent teeth, hypoplastic conical teeth, and underdevelopment of the alveolar ridges. The options for a definitive treatment plan include fixed, removable or implant-supported prostheses, singly or in combination. This clinical report describes the prosthetic rehabilitation of an 11-year-old boy with hereditary ectodermal dysplasia. Maxillary flexible removable partial denture and mandibular conventional complete denture were fabricated to establish an acceptable masticatory function, speech, and esthetics for the patient. PMID:23320200

  3. Infective endocarditis and septic pulmonary embolism following scorpion sting envenoming in an 11-year-old child.

    PubMed

    Prakash, Vellasamy; Krishnamurthy, Sriram; Mahadevan, Subramanian; Bethou, Adhisivam; Deepak Barathi, S

    2014-05-01

    Scorpion sting is one of the common paediatric toxicological problems encountered in southern India. This rural emergency often results in an autonomic storm causing peripheral circulatory failure and/or congestive cardiac failure, leading to pulmonary oedema. A rare case of scorpion sting envenoming in an 11-year-old boy that led to local cellulitis, dyspnoea and congestive heart failure is presented. This was followed by a persistent high-grade fever which lasted for more than 2 weeks and was complicated by fatal Staphylococcus aureus infective endocarditis and septic pulmonary embolism. Although infective endocarditis has been reported occasionally in adults following scorpion sting, this is the first case of infective endocarditis in a native valve in a child following scorpion sting. The literature is reviewed and the mechanisms for this association are discussed.

  4. North-south asymmetry in small and large sunspot group activity and violation of even-odd solar cycle rule

    NASA Astrophysics Data System (ADS)

    Javaraiah, J.

    2016-07-01

    According to Gnevyshev-Ohl (G-O) rule an odd-numbered cycle is stronger than its preceding even-numbered cycle. In the modern time the cycle pair (22, 23) violated this rule. By using the combined Greenwich Photoheliographic Results (GPR) and Solar Optical Observing Network (SOON) sunspot group data during the period 1874-2015, and Debrecen Photoheliographic Data (DPD) of sunspot groups during the period 1974-2015, here we have found that the solar cycle pair (22, 23) violated the G-O rule because, besides during cycle 23 a large deficiency of small sunspot groups in both the northern and the southern hemispheres, during cycle 22 a large abundance of small sunspot groups in the southern hemisphere. In the case of large and small sunspot groups the cycle pair (22, 23) violated the G-O rule in the northern and southern hemispheres, respectively, suggesting the north-south asymmetry in solar activity has a significant contribution in the violation of G-O rule. The amplitude of solar cycle 24 is smaller than that of solar cycle 23. However, Coronal Mass Ejections (CMEs) rate in the rising phases of the cycles 23 and 24 are almost same (even slightly large in cycle 24). From both the SOON and the DPD sunspot group data here we have also found that on the average the ratio of the number (counts) of large sunspot groups to the number of small sunspot groups is larger in the rising phase of cycle 24 than that in the corresponding phase of cycle 23. We suggest this could be a potential reason for the aforesaid discrepancy in the CME rates during the rising phases of cycles 23 and 24. These results have significant implication on solar cycle mechanism.

  5. Utility activities for nuclear power plant life cycle management and license renewal

    SciTech Connect

    Negin, C.A.; Klein, D.J.; Fleck, J.M.

    1995-05-01

    This report provides guidance to a utility on what steps should be taken, what industry activities have been undertaken, and what products have been developed or are under development for life cycle management and license renewal (LCM/LR) activities. The report identifies those activities a utility may undertake when initially considering the license renewal option through issuance of a renewed license by the NRC, and beyond. Utility activities are distributed in four phases which are: Phase I, Investigate and Determine Corporate Need, Feasibility, and Decision to Proceed; Phase II, Establish the License Renewal Program; Phase III, Implement the License Renewal Program; Phase IV, Obtain a Renewed License. The four phases are first illustrated in a broad, integrated overview and then in a level of detail adequate for input to management planning. The report will prove useful for utility managers who are beginning a program as well as for those who have a program in progress and want to make sure they have considered the experience of others and available industry products. Each activity in each phase is described along with reference to products that can support an individual utility`s conduct of that activity. Associated industry products for life cycle management evaluations of plant systems, structures, and components are further delineated. The final section of the report identifies the conclusions to date and discusses how some utilities have determined that aging is adequately managed for specific components. The products referenced in the body of the report are included in an appendix along with others that have been conducted under related programs, but may not be directly useful for support of license renewal activities.

  6. A mechanistic examination of redox cycling activity in carbonaceous particulate matter

    NASA Astrophysics Data System (ADS)

    McWhinney, Robert David

    Mechanistic aspects of carbonaceous aerosol toxicity were examined with respect to the ability of particles to catalyse reactive oxygen species-generating redox cycling reactions. To investigate the role of secondary organic material, we examined two systems. In the first, two-stroke engine exhaust particles were found to increase their ability to catalyse redox cycling in the presence of a reducing agent, dithiothreitol (DTT), when the exhaust was exposed to ozone. This occurred through deposition of redox-active secondary organic aerosol (SOA) onto the particle that was ten times more redox active per microgram than the primary engine particle. In the second system, naphthalene SOA formed highly redox active particles. Activity was strongly correlated to the amount of the 1,4- and 1,2-naphthoquinone measured in the particle phase. However, these species and the newly quantified naphthalene oxidation product 5-hydroxy-1,4-naphthoquinone accounted for only 30% of the observed DTT decay from the particles. Gas-particle partitioning coefficients suggest 1,4- and 1,2- naphthoquinone are not strong contributors to ambient particle redox activity at 25 °C. However, a large number of redox active species are unidentified. Some of these may be highly oxidised products of sufficiently low vapour pressure to be atmospherically relevant. DTT activity of diesel particles was found to be high per unit mass. The activity was found to be associated with the insoluble fraction as filtration of the particles nearly eliminated DTT decay. Neither methanol nor dichloromethane extracts of diesel particles exhibited redox activity, indicating that the redox active species are associated with the black carbon portion of the particles. Examination of particle concentration techniques found that use of water condensation to grow and concentrate particles introduced a large organic artefact to the particles. Experiments with concentrated inorganic particles suggest that the source of this

  7. Change in waist circumference over 11 years and current waist circumference independently predict elevated CRP in Filipino women

    PubMed Central

    Rutherford, J.N.; McDade, T.W.; Lee, N.R.; Adair, L.; Kuzawa, C.

    2012-01-01

    C-reactive protein, a marker of chronic, low-grade inflammation, is strongly associated with current central adiposity, and has been linked to elevated risk of cardiovascular disease. Less is known about the contribution of longitudinal change in waist circumference to current inflammation. We evaluated the extent to which current waist circumference and change over an 11-year interval contribute independently to low-grade systemic inflammation measured in a group of 1,294 women, 35–69 years, participating in the Cebu Longitudinal Nutrition and Health Survey in the Philippines. Waist circumference was measured at the time of blood draw for CRP analysis in 2005 and during an earlier survey in 1994. A waist circumference delta variable was constructed by subtracting current circumference from past circumference. We used logistic regression models to predict having an elevated plasma CRP concentration (3 mg/L11 years was a significant and independent predictor of elevated CRP risk (OR=1.023, 95% CI=1.00,1.05, P<0.05). Considering the average increase over time, the cumulative risk of elevated CRP due to increased central adiposity was 20.1%. However, women who reduced their waist circumference between 1994 and 2005 had greatly reduced risk (6.2%), suggesting that even long-term inflammatory burden can be reversed by weight loss. Although current waist circumference is an important contributor to risk of elevated systemic inflammation in this as in other populations, history of central adiposity may be an independent phenomenon. PMID:19856425

  8. Longitudinal association between early life socio-environmental factors and attention function at the age 11 years.

    PubMed

    Forns, Joan; Torrent, Maties; Garcia-Esteban, Raquel; Cáceres, Alejandro; Pilar Gomila, María; Martinez, David; Morales, Eva; Julvez, Jordi; Grimalt, Joan O; Sunyer, Jordi

    2012-08-01

    Prenatal and early-life exposures can affect the course of children's neuropsychological development well into pre-adolescence, given the vulnerability of the developing brain. However, it is unknown which socio-environmental factors at early childhood can influence specific cognitive processes like attention at a later age. In this study, we aim to determine social and environmental exposures in early childhood that may be associated with attention function of 11-year-olds. We measured attention function using the continuous performance test-II (CPT-II) on 393 11-year old children from the Menorca's birth-cohort within the INMA-project (Spain), and pre-selected a list of socio-environmental observations taken when they were up to 4 years of age. We found that earlier socio-environmental characteristics, such as parental social class, educational level and maternal mental health are associated with later inattentive and impulsive symptomatology through a higher rate of omission and commission errors. In addition, omission errors were higher in children with atopy and lower in those whose mothers took dietary supplementation with folic acid and vitamins during pregnancy. Breastfeeding played a protective role against commission errors, while higher DDE and PCBs levels at age 4 were associated with slow speed response. Our findings suggest that a number of life socio-environmental factors during prenatal life and early childhood, such as socio-demographic characteristics, breastfeeding, maternal nutritional supplementation with folic acid and vitamins and exposure to some organochlorine compounds may influence inattentive and hyperactive/impulsive symptomatology during pre-adolescence. PMID:22608140

  9. Injuries, Death, and Disability Associated with 11 Years of Conflict in Baghdad, Iraq: A Randomized Household Cluster Survey

    PubMed Central

    Lafta, Riyadh; Al-Shatari, Sahar; Cherewick, Megan; Galway, Lindsay; Mock, Charles; Hagopian, Amy; Flaxman, Abraham; Takaro, Tim; Greer, Anna; Kushner, Adam; Burnham, Gilbert

    2015-01-01

    Background The objective of this study was to characterize injuries, deaths, and disabilities arising during 11 years of conflict in Baghdad. Methods Using satellite imagery and administrative population estimated size for Baghdad, 30 clusters were selected, proportionate to population size estimates. Interviews were conducted during April and May 2014 in 900 households containing 5148 persons. Details about injuries and disabilities occurring from 2003 through May 2014 and resultant disabilities were recorded. Findings There were 553 injuries reported by Baghdad residents, 225 of which were intentional, and 328 unintentional. For intentional injuries, the fatality rate was 39.1% and the disability rate 56.0%. Gunshots where the major cause of injury through 2006 when blasts/explosions became the most common cause and remained so through 2014. Among unintentional injuries, the fatality rate was 7.3% and the disability rate 77.1%. The major cause of unintentional injuries was falls (131) which have increased dramatically since 2008, followed by traffic related injuries (81), which have steadily increased. The proportion of injuries ending in disabilities remained fairly constant through the survey period. Interpretation Intentional injuries added substantially to the burden of unintentional injuries for the population. For Baghdad, the phases of the Iraqi conflict are reflected in the patterns of injuries and consequent deaths reported. The scale of injuries during conflict is most certainly under-reported. Difficulties recalling injuries in a survey covering 11 years is a limitation, but it is likely that minor injuries were under-reported more than severe injuries. The in- and out-migration of Baghdad populations likely had effects on the events reported which we could not measure or estimate. Damage to the health infrastructure and the flight of health workers may have contributed to mortality and morbidity. Civilian injuries as well as mortality should be

  10. Longitudinal association between early life socio-environmental factors and attention function at the age 11 years.

    PubMed

    Forns, Joan; Torrent, Maties; Garcia-Esteban, Raquel; Cáceres, Alejandro; Pilar Gomila, María; Martinez, David; Morales, Eva; Julvez, Jordi; Grimalt, Joan O; Sunyer, Jordi

    2012-08-01

    Prenatal and early-life exposures can affect the course of children's neuropsychological development well into pre-adolescence, given the vulnerability of the developing brain. However, it is unknown which socio-environmental factors at early childhood can influence specific cognitive processes like attention at a later age. In this study, we aim to determine social and environmental exposures in early childhood that may be associated with attention function of 11-year-olds. We measured attention function using the continuous performance test-II (CPT-II) on 393 11-year old children from the Menorca's birth-cohort within the INMA-project (Spain), and pre-selected a list of socio-environmental observations taken when they were up to 4 years of age. We found that earlier socio-environmental characteristics, such as parental social class, educational level and maternal mental health are associated with later inattentive and impulsive symptomatology through a higher rate of omission and commission errors. In addition, omission errors were higher in children with atopy and lower in those whose mothers took dietary supplementation with folic acid and vitamins during pregnancy. Breastfeeding played a protective role against commission errors, while higher DDE and PCBs levels at age 4 were associated with slow speed response. Our findings suggest that a number of life socio-environmental factors during prenatal life and early childhood, such as socio-demographic characteristics, breastfeeding, maternal nutritional supplementation with folic acid and vitamins and exposure to some organochlorine compounds may influence inattentive and hyperactive/impulsive symptomatology during pre-adolescence.

  11. A longitudinal study of grapheme-color synesthesia in childhood: 6/7 years to 10/11 years

    PubMed Central

    Simner, Julia; Bain, Angela E.

    2013-01-01

    Grapheme-color synesthesia is a condition characterized by enduring and consistent associations between letter/digits and colors. This study is the continuation of longitudinal research begun by Simner et al. (2009) which aimed to explore the development of this condition in real time within a childhood population. In that earlier study we randomly sampled over 600 children and tested them aged 6/7 and 7/8 years. We identified the child synesthetes within that cohort and measured their development over 1 year, in comparison to a group of non-synesthetic children with both average and superior memories. We were able to show the beginnings of a developmental progression in which synesthetic associations (e.g., A = red) mature over time from relatively chaotic pairings into a system of fixed consistent associations. In the current study we return to this same population three years later when participants are now 10/11 years. We used the same paired-association memory task to determine the synesthetic status of our participants and to also establish synesthetes' inventories of grapheme-color associations. We compared their inventories to those from age 6/7 and 7/8 years to examine how synesthesia matures over time. Together with earlier findings, our study shows that grapheme-color synesthesia emerges with a protracted trajectory, with 34% of letters/digits fixed at age 6/7 years, 48% fixed at 7/8 years and 71% fixed at 10/11 years. We also show several cases where synesthesia is not developing in the same time-frame as peers, either because it has died out at an older age, or because it was slower to develop than other cases. Our study paints the first picture of the emergence of synesthesia in real-time over four years within a randomly sampled population of child synesthetes. PMID:24312035

  12. Blood lead levels of 4-11-year-old Mexican American, Puerto Rican, and Cuban children.

    PubMed Central

    Carter-Pokras, O; Pirkle, J; Chavez, G; Gunter, E

    1990-01-01

    Data from the Hispanic Health and Nutrition Examination Survey were used to estimate arithmetic mean blood lead and percent with elevated blood lead [25 micrograms per deciliter (micrograms per dl) or greater] for 4-11-year-old Mexican American, Puerto Rican, and Cuban children. The sample size was 1,390 for Mexican American children, 397 for Puerto Rican children, and 114 for Cuban children. Puerto Rican children had the highest mean blood lead levels (11.5 micrograms per dl), followed by Mexican American children (10.4 micrograms per dl) and Cuban children (8.6 micrograms per dl, P less than .05). Puerto Rican children had the highest percent with elevated blood lead (2.7 percent); 1.6 percent of Mexican American children had elevated blood lead; less than 1 percent (0.9 percent) of the Cuban children had elevated blood lead (P less than .05). Mexican American girls had a lower mean blood lead level than did boys: 9.7 micrograms per dl versus 11.0 micrograms per dl (P less than .05). For both Puerto Rican and Mexican American children, younger age indicated a higher risk of having elevated blood lead levels. Mexican American children who lived in poverty had higher mean blood lead levels than did Mexican American children who did not live in poverty--11.6 micrograms per dl versus 9.6 micrograms per dl (P less than .05). Despite advances in primary prevention of lead toxicity in children during the past 10 years, many Hispanic children are at risk of lead toxicity. Approximately 19,000 Mexican American 4-11-year-old children living in the Southwest and approximately 8,000 Puerto Rican children living in the New York City area had elevated blood lead levels (greater than or equal to 25 micrograms per dl) during 1982-84. PMID:2116641

  13. A longitudinal study of grapheme-color synesthesia in childhood: 6/7 years to 10/11 years.

    PubMed

    Simner, Julia; Bain, Angela E

    2013-01-01

    Grapheme-color synesthesia is a condition characterized by enduring and consistent associations between letter/digits and colors. This study is the continuation of longitudinal research begun by Simner et al. (2009) which aimed to explore the development of this condition in real time within a childhood population. In that earlier study we randomly sampled over 600 children and tested them aged 6/7 and 7/8 years. We identified the child synesthetes within that cohort and measured their development over 1 year, in comparison to a group of non-synesthetic children with both average and superior memories. We were able to show the beginnings of a developmental progression in which synesthetic associations (e.g., A = red) mature over time from relatively chaotic pairings into a system of fixed consistent associations. In the current study we return to this same population three years later when participants are now 10/11 years. We used the same paired-association memory task to determine the synesthetic status of our participants and to also establish synesthetes' inventories of grapheme-color associations. We compared their inventories to those from age 6/7 and 7/8 years to examine how synesthesia matures over time. Together with earlier findings, our study shows that grapheme-color synesthesia emerges with a protracted trajectory, with 34% of letters/digits fixed at age 6/7 years, 48% fixed at 7/8 years and 71% fixed at 10/11 years. We also show several cases where synesthesia is not developing in the same time-frame as peers, either because it has died out at an older age, or because it was slower to develop than other cases. Our study paints the first picture of the emergence of synesthesia in real-time over four years within a randomly sampled population of child synesthetes.

  14. Caregiver perceptions of the food marketing environment of African-American 3–11-year-olds: a qualitative study

    PubMed Central

    Baskin, Monica L; Herbey, Ivan; Williams, Ronnie; Ard, Jamy D; Ivankova, Nataliya; Odoms-Young, Angela

    2014-01-01

    Objective To assess caregivers’ perceptions of the extent to which the food marketing environment influences food consumption among African-American children (aged 3–11 years) in order to generate potential strategies to make the marketing environment more favourable to healthier eating. Design Individual semi-structured interviews with caregivers were conducted by trained community leaders to ascertain their awareness of and perceptions about food marketing environments contributing to African-American children’s food consumption. Setting Six predominantly African-American communities in metro Birmingham, Alabama, USA with high proportions of school-age children and lower-income residents. Subjects Caregivers (n 25) were predominantly female (93 %) and either parents/guardians (64 %) or grandparents (28 %) of African-American children aged 3–11 years. Caregiver mean age was 43 years and 46% had lived in their current residence for over 10 years. Results Caregivers reported all aspects of the food marketing matrix as supporting unhealthy eating among African-American youth. Child preference for foods higher in fat and sugar, lower pricing of less healthy foods, limited access to healthier food retailers and targeted advertisements were particularly influential on the food selection, acquisition and consumption of children. Company loyalty, corporate sponsorship of local events and conflicts over parental v. food company responsibility contributed to less consensus about the overall impact (positive or negative) of food companies in African-American communities. Conclusions While caregivers perceived aspects of their food marketing environments as primarily contributing to unhealthy eating among African-American children, framing the demand for changes in the food marketing environments of African-American youth may be particularly challenging. PMID:23830058

  15. Photometric Variations in Spotted Pleiades Stars as Probes of Long-Term Activity Cycles

    NASA Astrophysics Data System (ADS)

    Bardenett, E.; Milingo, J. B.; Marschall, L. A.; Backman, D. E.

    2004-12-01

    Through the collaborative efforts of undergraduates and faculty at Franklin & Marshall and Gettysburg Colleges, we present new photometric data for 3 K-type stars in the Pleiades. Continuing 8+ years of observations, this data contributes to the long-term study of photometric variations in these stars. These young stars have rotational light curves with V-band amplitudes of a few percent (up to 10% in the most active stars) due to large photospheric active regions or "starspots". Quantifying the level of starspot activity from year to year allows us to look for long-term trends analogous to the solar sunspot cycle. These observations were acquired with the National Undergraduate Research Observatory's (NURO) 31" telescope, which is operated by Lowell Observatory and Northern Arizona University. This work is supported by Franklin & Marshall College, the Delaware Space Grant Consortium, and Arizona Space Grant (NASA Space Grant programs).

  16. Changes in voluntary activation assessed by transcranial magnetic stimulation during prolonged cycling exercise.

    PubMed

    Jubeau, Marc; Rupp, Thomas; Perrey, Stephane; Temesi, John; Wuyam, Bernard; Levy, Patrick; Verges, Samuel; Millet, Guillaume Y

    2014-01-01

    Maximal central motor drive is known to decrease during prolonged exercise although it remains to be determined whether a supraspinal deficit exists, and if so, when it appears. The purpose of this study was to evaluate corticospinal excitability and muscle voluntary activation before, during and after a 4-h cycling exercise. Ten healthy subjects performed three 80-min bouts on an ergocycle at 45% of their maximal aerobic power. Before exercise and immediately after each bout, neuromuscular function was evaluated in the quadriceps femoris muscles under isometric conditions. Transcranial magnetic stimulation was used to assess voluntary activation at the cortical level (VATMS), corticospinal excitability via motor-evoked potential (MEP) and intracortical inhibition by cortical silent period (CSP). Electrical stimulation of the femoral nerve was used to measure voluntary activation at the peripheral level (VAFNES) and muscle contractile properties. Maximal voluntary force was significantly reduced after the first bout (13 ± 9%, P<0.01) and was further decreased (25 ± 11%, P<0.001) at the end of exercise. CSP remained unchanged throughout the protocol. Rectus femoris and vastus lateralis but not vastus medialis MEP normalized to maximal M-wave amplitude significantly increased during cycling. Finally, significant decreases in both VATMS and VAFNES (∼ 8%, P<0.05 and ∼ 14%, P<0.001 post-exercise, respectively) were observed. In conclusion, reductions in VAFNES after a prolonged cycling exercise are partly explained by a deficit at the cortical level accompanied by increased corticospinal excitability and unchanged intracortical inhibition. When comparing the present results with the literature, this study highlights that changes at the cortical and/or motoneuronal levels depend not only on the type of exercise (single-joint vs. whole-body) but also on exercise intensity and/or duration. PMID:24586559

  17. Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis.

    PubMed

    Sontakke, Vyankat A; Lawande, Pravin P; Kate, Anup N; Khan, Ayesha; Joshi, Rakesh; Kumbhar, Anupa A; Shinde, Vaishali S

    2016-04-26

    An efficient route was developed for synthesis of bicyclic benzimidazole nucleosides from readily available d-glucose. The key reactions were Vörbruggen glycosylation and ring closing metathesis (RCM). Primarily, to understand the mode of DNA binding, we performed a molecular docking study and the binding was found to be in the minor groove region. Based on the proposed binding model, UV-visible and fluorescence spectroscopic techniques using calf thymus DNA (CT-DNA) demonstrated a non-intercalative mode of binding. Antiproliferative activity of nucleosides was tested against MCF-7 and MDA-MB-231 breast cancer cell lines and found to be active at low micromolar concentrations. Compounds and displayed significant antiproliferative activity as compared to and with the reference anticancer drug, doxorubicin. Cell cycle analysis showed that nucleoside induced cell cycle arrest at the S-phase. Confocal microscopy has been performed to validate the induction of cellular apoptosis. Based on these findings, such modified bicyclic benzimidazole nucleosides will make a significant contribution to the development of anticancer drugs. PMID:27074628

  18. Multiple late Triassic carbon cycle perturbations preceding intensified volcanic activity in the Central Atlantic Magmatic Province

    NASA Astrophysics Data System (ADS)

    Ruhl, Micha; Kürschner, Wolfram M.

    2010-05-01

    The end-Triassic mass extinction (~201.5 Ma), marked by terrestrial ecosystem changes and a 50% loss in marine biodiversity, coincides with a major disruption of the global carbon cycle. These events closely coincide with the onset of Central Atlantic Magmatic Province emplacement (Deenen et al., 2010) and the subsequent release of isotopically depleted carbon as gaseous CO2 and from the methane hydrate reservoir. Here we show that the end-Triassic C-cycle perturbation is preceded by two successive 2-3‰ Rhaetian negative excursions in marine and continental δ13CTOC records from the western Tethys and north-west European sections. A coinciding, albeit slightly smaller, negative excursion in a δ13C leaf-record (Lepidopteris ottonis) further suggests successive 13C depletion of the late Triassic global atmosphere. Extensive dyke and sill systems that allowed major flood basalt emplacement in the Central Atlantic Magmatic Province, already intruded sedimentary basins over large parts of Pangea during the late Triassic. Subsurface thermal metamorphism of organic rich strata potentially led to oxidation of organic carbon and the transfer of isotopically depleted carbon to the exogenic carbon pool. In this way causing changes in the global C-cycle already before the onset of major volcanic activity.

  19. Abundances and potential activities of nitrogen cycling microbial communities along a chronosequence of a glacier forefield

    PubMed Central

    Brankatschk, Robert; Töwe, Stefanie; Kleineidam, Kristina; Schloter, Michael; Zeyer, Josef

    2011-01-01

    Glacier forefields are ideal ecosystems to study the development of nutrient cycles as well as single turnover processes during soil development. In this study, we examined the ecology of the microbial nitrogen (N) cycle in bulk soil samples from a chronosequence of the Damma glacier, Switzerland. Major processes of the N cycle were reconstructed on the genetic as well as the potential enzyme activity level at sites of the chronosequence that have been ice-free for 10, 50, 70, 120 and 2000 years. In our study, we focused on N fixation, mineralization (chitinolysis and proteolysis), nitrification and denitrification. Our results suggest that mineralization, mainly the decomposition of deposited organic material, was the main driver for N turnover in initial soils, that is, ice-free for 10 years. Transient soils being ice-free for 50 and 70 years were characterized by a high abundance of N fixing microorganisms. In developed soils, ice-free for 120 and 2000 years, significant rates of nitrification and denitrification were measured. Surprisingly, copy numbers of the respective functional genes encoding the corresponding enzymes were already high in the initial phase of soil development. This clearly indicates that the genetic potential is not the driver for certain functional traits in the initial phase of soil formation but rather a well-balanced expression of the respective genes coding for selected functions. PMID:21124490

  20. Ribulose bisphosphate carboxylase activity and a Calvin cycle gene cluster in Sulfobacillus species.

    PubMed

    Caldwell, Paul E; MacLean, Martin R; Norris, Paul R

    2007-07-01

    The Calvin-Benson-Bassham (CBB) cycle has been extensively studied in proteobacteria, cyanobacteria, algae and plants, but hardly at all in Gram-positive bacteria. Some characteristics of ribulose bisphosphate carboxylase/oxygenase (RuBisCO) and a cluster of potential CBB cycle genes in a Gram-positive bacterium are described in this study with two species of Sulfobacillus (Gram-positive, facultatively autotrophic, mineral sulfide-oxidizing acidophiles). In contrast to the Gram-negative, iron-oxidizing acidophile Acidithiobacillus ferrooxidans, Sulfobacillus thermosulfidooxidans grew poorly autotrophically unless the CO(2) concentration was enhanced over that in air. However, the RuBisCO of each organism showed similar affinities for CO(2) and for ribulose 1,5-bisphosphate, and similar apparent derepression of activity under CO(2) limitation. The red-type, form I RuBisCO of Sulfobacillus acidophilus was confirmed as closely related to that of the anoxygenic phototroph Oscillochloris trichoides. Eight genes potentially involved in the CBB cycle in S. acidophilus were clustered in the order cbbA, cbbP, cbbE, cbbL, cbbS, cbbX, cbbG and cbbT.

  1. Structure-activity relationship between carboxylic acids and T cell cycle blockade.

    PubMed

    Gilbert, Kathleen M; DeLoose, Annick; Valentine, Jimmie L; Fifer, E Kim

    2006-04-01

    This study was designed to examine the potential structure-activity relationship between carboxylic acids, histone acetylation and T cell cycle blockade. Toward this goal a series of structural homologues of the short-chain carboxylic acid n-butyrate were studied for their ability to block the IL-2-stimulated proliferation of cloned CD4+ T cells. The carboxylic acids were also tested for their ability to inhibit histone deacetylation. In addition, Western blotting was used to examine the relative capacity of the carboxlic acids to upregulate the cyclin kinase-dependent inhibitor p21cip1 in T cells. As shown earlier n-butyrate effectively inhibited histone deacetylation. The increased acetylation induced by n-butyrate was associated with the upregulation of the cyclin-dependent kinase inhibitor p21cip1 and the cell cycle blockade of CD4+ T cells. Of the other carboxylic acids studied, the short chain acids, C3-C5, without branching were the best inhibitors of histone deacetylase. This inhibition correlated with increased expression of the cell cycle blocker p21cip1, and the associated suppression of CD4+ T cell proliferation. The branched-chain carboxylic acids tested were ineffective in all the assays. These results underline the relationship between the ability of a carboxylic acid to inhibit histone deacetylation, and their ability to block T cell proliferation, and suggests that branching inhibits these effects.

  2. Microbial activity and biogeochemical cycling in first-order Russian Arctic streams

    NASA Astrophysics Data System (ADS)

    Rhoades, R. E.; Lynch, L. M.; Ortega, J. C.; Holmes, R. M.; Mann, P. J.; Vonk, J. E.; Schade, J. D.

    2011-12-01

    Global climate change is strongly impacting Arctic ecosystems and is predicted to lead to thawing of permafrost soils. These soils are rich in organic matter and other nutrients and influence biogeochemical cycling in terrestrial and aquatic ecosystems. Small arctic streams are likely to be the first aquatic ecosystems to receive materials exported as soils warm. These first-order streams are characterized by strong interactions between the water column and stream bottom and have the potential to affect nutrient flux. Previous studies suggest that phosphorous availability limits biological productivity in many first-order arctic streams, however, they remain understudied, particularly in the Russian Arctic. Our objective was to assess microbial activity and biogeochemical cycling among arctic streams. We used three approaches to meet our objectives, including a survey of 9 streams, intensive longitudinal sampling in 5 streams, and nutrient pulse addition experiments in 4 streams, designed to assess the potential for limitation by N or P. We measured pH, temperature, dissolved oxygen, NH4, SRP, DOC, and TDN at all sampling sites. We also conducted biological oxygen demand (BOD) incubations designed to assess DOC lability, and correlated these measurements with background nutrient concentrations. We found a strong positive linear correlation between BOD and phosphate concentration, suggesting P limitation of production and/or consumption of labile DOC. To complement ambient stream measurements, we conducted whole stream nutrient addition experiments to calculate N and P uptake lengths, which we then used to infer whether N or P is more likely to limit biological processes, and the degree of coupling between N and P cycling. Results from the nutrient addition experiments suggest both N and P limitation among streams depending on stream location and characteristics. In addition, these experiments suggest a significant, but complex interaction between N and P cycles

  3. Kinetic energy budgets during the life cycle of intense convective activity

    NASA Technical Reports Server (NTRS)

    Fuelberg, H. E.; Scoggins, J. R.

    1978-01-01

    Synoptic-scale data at three- and six-hour intervals are employed to study the relationship between changing kinetic energy variables and the life cycles of two severe squall lines. The kinetic energy budgets indicate a high degree of kinetic energy generation, especially pronounced near the jet-stream level. Energy losses in the storm environment are due to the transfer of kinetic energy from grid to subgrid scales of motion; large-scale upward vertical motion carries aloft the kinetic energy generated by storm activity at lower levels. In general, the time of maximum storm intensity is also the time of maximum energy conversion and transport.

  4. On the Relationship Between Solar Wind Speed, Geomagnetic Activity, and the Solar Cycle Using Annual Values

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    The aa index can be decomposed into two separate components: the leading sporadic component due to solar activity as measured by sunspot number and the residual or recurrent component due to interplanetary disturbances, such as coronal holes. For the interval 1964-2006, a highly statistically important correlation (r = 0.749) is found between annual averages of the aa index and the solar wind speed (especially between the residual component of aa and the solar wind speed, r = 0.865). Because cyclic averages of aa (and the residual component) have trended upward during cycles 11-23, cyclic averages of solar wind speed are inferred to have also trended upward.

  5. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling.

    PubMed

    Jensen, T H; Neville, M; Rain, J C; McCarthy, T; Legrain, P; Rosbash, M

    2000-11-01

    Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the NES receptor CRM1/Crm1p. We have carried out a yeast two-hybrid screen with Crm1p as a bait. The Crm1p-interacting clones were subscreened for nuclear export activity in a visual assay utilizing the Crm1p-inhibitor leptomycin B (LMB). This approach identified three Saccharomyces cerevisiae proteins not previously known to have nuclear export activity. These proteins are the 5' RNA triphosphatase Ctl1p, the cell cycle-regulated transcription factor Ace2p, and a protein encoded by the previously uncharacterized open reading frame YDR499W. Mutagenesis analysis show that YDR499Wp contains an NES that conforms to the consensus sequence for leucine-rich NESs. Mutagenesis of Ctl1p and Ace2p were unable to identify specific NES residues. However, a 29-amino-acid region of Ace2p, rich in hydrophobic residues, contains nuclear export activity. Ace2p accumulates in the nucleus at the end of mitosis and activates early-G(1)-specific genes. We now provide evidence that Ace2p is nuclear not only in late M-early G(1) but also during other stages of the cell cycle. This feature of Ace2p localization explains its ability to activate genes such as CUP1, which are not expressed in a cell cycle-dependent manner.

  6. Investigating the Potential of Activity Tracking App Data to Estimate Cycle Flows in Urban Areas

    NASA Astrophysics Data System (ADS)

    Haworth, J.

    2016-06-01

    Traffic congestion and its associated environmental effects pose a significant problem for large cities. Consequently, promoting and investing in green travel modes such as cycling is high on the agenda for many transport authorities. In order to target investment in cycling infrastructure and improve the experience of cyclists on the road, it is important to know where they are. Unfortunately, investment in intelligent transportation systems over the years has mainly focussed on monitoring vehicular traffic, and comparatively little is known about where cyclists are on a day to day basis. In London, for example, there are a limited number of automatic cycle counters installed on the network, which provide only part of the picture. These are supplemented by surveys that are carried out infrequently. Activity tracking apps on smart phones and GPS devices such as Strava have become very popular over recent years. Their intended use is to track physical activity and monitor training. However, many people routinely use such apps to record their daily commutes by bicycle. At the aggregate level, these data provide a potentially rich source of information about the movement and behaviour of cyclists. Before such data can be relied upon, however, it is necessary to examine their representativeness and understand their potential biases. In this study, the flows obtained from Strava Metro (SM) are compared with those obtained during the 2013 London Cycle Census (LCC). A set of linear regression models are constructed to predict LCC flows using SM flows along with a number of dummy variables including road type, hour of day, day of week and presence/absence of cycle lane. Cross-validation is used to test the fitted models on unseen LCC sites. SM flows are found to be a statistically significant (p<0.0001) predictor of total flows as measured by the LCC and the models yield R squared statistics of ~0.7 before considering spatio-temporal variation. The initial results indicate

  7. Anomalously extended minima of solar cycle~23

    NASA Astrophysics Data System (ADS)

    Singh, Ambika; Tiwari, Anil Kumar; Agrawal, S. P.

    The new millennium extended solar minimum of solar cycle 23 (2007-2009) contains some distinct surprises and is anomalous in comparison to the past few solar cycles. In general, the level of solar activity goes through the cyclic changes lasting roughly 11 years. The last solar cycle 23 started in the year 1996 and was expected to last until 2006. Nevertheless, the solar activity minima continued beyond the year 2006 and lasted till 2009. In fact, anomalously, during the years 2007-09, a deep sunspot minima was observed at the end of the last solar cycle 23. It is observed that the sun had no sunspots continuously for over 50 days in July-August, 2009. More so, it is found that the solar cycle 23 has the longest quiet period as compared to the last many previous solar cycles. Anomalously low values of the geomagnetic disturbance Ap is observed during the whole quiet period (2007-09) of the sun, particularly in the month of January-September 2009, during which the high speed solar wind streams are also not observed. As such, the past solar cycle 23 seems to have the very long period of about 14 years, which is anomalously distinct from previous four solar cycles, besides the obvious Ap correlation of very low activity. The low values of the sunspot numbers in years 2007-2009 also have a very distinct effect in producing lowest modulation in cosmic ray intensity, with highest values of neutron monitor counts observed in the year 2009, as compared to that observed so far in previous solar cycles. These results are discussed in the light of many associated solar-terrestrial phenomena.

  8. On Solar Flares and Cycle 23

    NASA Astrophysics Data System (ADS)

    Kossobokov, Vladimir; Le Mouël, Jean-Louis; Courtillot, Vincent

    2012-02-01

    The anomalous character of Solar Cycle 23, which ended in the Summer of 2009, has been pointed out by many authors. It has even been proposed that the solar dynamo is undergoing a transition from a state of “grand maximum” to one of “regular oscillations”. We analyze the temporal distribution of the number and energy of solar flares, and the duration of intervals between them, over Cycles 21 to 23. We consider 32 355 flares of class C2 and larger (C2+) from the GOES catalogue. Daily values of X-ray flux (wavelengths 1 to 8 Å) have been computed by summing the energy proxies of the events. The series of daily numbers of C2+ solar flares are strongly correlated with their daily energy flux. The long duration of Cycle 23 (12.8 years based on sunspots, 13.2 years based on flares) and the long interval with no C2+ flare between the end of Cycle 23, and the start of Cycle 24 (466 days) are remarkable compared to the two earlier cycles. The amplitudes of extreme flares increase when the mean flux decreases. We have calculated running averages of energy flux over intervals going from 7 to 365 days. The singular shape of Cycle 23 is increasingly striking with increasing interval: in the first ≈ 70% of the cycle (displayed on a logarithmic scale) we see linearly rising maxima, whereas minima are aligned along a descending slope for the latter part of the cycle. The energy flux oscillates between these and takes the shape of a bifurcation, starting near 2002 (a time when it is suggested that photospheric fields were abruptly reduced). Inter-event intervals between successive C2+ flares undergo quasi-periodic (≈ 11 years) oscillations between two distinct states, which we call “active” and “quiet”, with extremely sharp onset and termination. The ratio of time spent in the active vs. quiet states ranges from 1.8 to 1.4 for Cycles 21 to 23, Cycle 23 having the longest quiet period. It has been proposed that anomalous Cycle 23 resembles Cycle 4, which was

  9. Soil Microbial Activity Provides Insight to Carbon Cycling in Shrub Ecotones of Sub-Arctic Sweden

    NASA Astrophysics Data System (ADS)

    Marek, E.; Kashi, N. N.; Chen, J.; Hobbie, E. A.; Schwan, M. R.; Varner, R. K.

    2015-12-01

    Shrubs are expanding in Arctic and sub-Arctic regions due to rising atmospheric temperatures. Microbial activity increases as growing temperatures cause permafrost warming and subsequent thaw, leading to a greater resource of soil nutrients enabling shrub growth. Increased carbon inputs from shrubs is predicted to result in faster carbon turnover by microbial decomposition. Further understanding of microbial activity underneath shrubs could uncover how microbes and soil processes interact to promote shrub expansion and carbon cycling. To address how higher soil carbon input from shrubs influences decomposition, soil samples were taken across a heath, shrub, and forest ecotone gradient at two sites near Abikso, Sweden. Samples were analyzed for soluble carbon and nitrogen, microbial abundance, and microbial activity of chitinase, glucosidase, and phosphatase to reflect organic matter decomposition and availability of nitrogen, carbon, and phosphate respectively. Chitinase activity positively correlated with shrub cover, suggesting microbial demands for nitrogen increase with higher shrub cover. Glucosidase activity negatively correlated with shrub cover and soluble carbon, suggesting decreased microbial demand for carbon as shrub cover and carbon stores increase. Lower glucosidase activity in areas with high carbon input from shrubs implies that microbes are decomposing carbon less readily than carbon is being put into the soil. Increasing soil carbon stores in shrub covered areas can lead to shrubs becoming a net carbon sink and a negative feedback to changing climate.

  10. Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response

    PubMed Central

    Bujdoso, Raymond; Landgraf, Matthias; Jackson, Walker S; Thackray, Alana M

    2015-01-01

    Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, motor neuron disease, tauopathies and prion diseases. Collectively, these conditions are a challenge to society because of the increasing aged population and through the real threat to human food security by animal prion diseases. It is therefore important to understand the cellular and molecular mechanisms that underlie protein misfolding-induced neurotoxicity as this will form the basis for designing strategies to alleviate their burden. Prion diseases are an important paradigm for neurodegenerative conditions in general since several of these maladies have now been shown to display prion-like phenomena. Increasingly, cell cycle activity and the DNA damage response are recognised as cellular events that participate in the neurotoxic process of various neurodegenerative diseases, and their associated animal models, which suggests they are truly involved in the pathogenic process and are not merely epiphenomena. Here we review the role of cell cycle activity and the DNA damage response in neurodegeneration associated with protein misfolding diseases, and suggest that these events contribute towards prion-induced neurotoxicity. In doing so, we highlight PrP transgenic Drosophila as a tractable model for the genetic analysis of transmissible mammalian prion disease. PMID:26279981

  11. Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes

    PubMed Central

    Chung, Chi-Li; Leung, Kam-Wing; Lu, Wan-Jung; Yen, Ting-Lin; He, Chia-Fu; Sheu, Joen-Rong; Lin, Kuan-Hung; Lien, Li-Ming

    2015-01-01

    Autoimmune diseases are a group of chronic inflammatory diseases that arise from inappropriate inflammatory responses. Hinokitiol, isolated from the wood of Chamaecyparis taiwanensis, engages in multiple biological activities. Although hinokitiol has been reported to inhibit inflammation, its immunological regulation in lymphocytes remains incomplete. Thus, we determined the effects of hinokitiol on concanavalin A- (ConA-) stimulated T lymphocytes from the spleens of mice. In the present study, the MTT assay revealed that hinokitiol (1–5 μM) alone did not affect cell viability of lymphocytes, but at the concentration of 5 μM it could reduce ConA-stimulated T lymphocyte proliferation. Moreover, propidium iodide (PI) staining revealed that hinokitiol arrested cell cycle of T lymphocytes at the G0/G1 phase. Hinokitiol also reduced interferon gamma (IFN-γ) secretion from ConA-activated T lymphocytes, as detected by an ELISA assay. In addition, hinokitiol also downregulated cyclin D3, E2F1, and Cdk4 expression and upregulated p21 expression. These results revealed that hinokitiol may regulate immune responses. In conclusion, we for the first time demonstrated that hinokitiol upregulates p21 expression and attenuates IFN-γ secretion in ConA-stimulated T lymphocytes, thereby arresting cell cycle at the G0/G1 phase. In addition, our findings also indicated that hinokitiol may provide benefits to treating patients with autoimmune diseases. PMID:26379747

  12. Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart.

    PubMed

    O'Tierney, P F; Anderson, D F; Faber, J J; Louey, S; Thornburg, K L; Giraud, G D

    2010-08-01

    The fetal heart is highly sensitive to changes in mechanical load. We have previously demonstrated that increased cardiac load can stimulate cell cycle activity and maturation of immature cardiomyocytes, but the effects of reduced load are not known. Sixteen fetal sheep were given either continuous intravenous infusion of lactated Ringer solution (LR) or enalaprilat, an angiotensin-converting enzyme inhibitor beginning at 127 days gestational age. After 8 days, fetal arterial pressure in the enalaprilat-infused fetuses (23.8 +/- 2.8 mmHg) was lower than that of control fetuses (47.5 +/- 4.7 mmHg) (P < 0.0001). Although the body weights of the two groups of fetuses were similar, the heart weight-to-body weight ratios of the enalaprilat-infused fetuses were less than those of the LR-infused fetuses (5.6 +/- 0.5 g/kg vs. 7.0 +/- 0.6 g/kg, P < 0.0001). Dimensions of ventricular myocytes were not different between control and enalaprilat-infused fetuses. However, there was a significant decrease in cell cycle activity in both the right ventricle (P < 0.005) and the left ventricle (P < 0.002) of the enalaprilat-infused fetuses. Thus, we conclude a sustained reduction in systolic pressure load decreases hyperplastic growth in the fetal heart. PMID:20484695

  13. Active Site, Catalytic Cycle, and Iodination Reactions of Vanadium Iodoperoxidase: A Computational Study.

    PubMed

    Pacios, Luis F; Gálvez, Oscar

    2010-05-11

    A combined computational study using molecular surfaces and Poisson-Boltzmann electrostatic potentials for proteins and quantum calculations on complexes representing the vanadate cofactor throughout the catalytic cycle is employed to study the activity of vanadium iodoperoxidase (VIPO) from alga Laminaria digitata . A model structure of VIPO is compared with available crystal structures of chloroperoxidases (VClPOs) and bromoperoxidases (VBrPOs) focusing on properties of the active site that concern halogen specificity. It is found that VIPO displays distinctive features regarding electrostatic potentials at the site cavity and the local topography of the cavity entrance. Quantum calculations on cofactor stages throughout the catalytic cycle reveal that, while steps involving binding of hydrogen peroxide and halide oxidization agree with available data on VBrPO, final formation and subsequent release of hypohalous acid could follow a different pathway consisting of His476-assisted protonation of bonded hypoiodite and further displacement by a water molecule. Ab initio free energies of reaction computed to explore iodination of organic substrates predict strongly exoergonic reactions with HOI, whereas other possible iodination reagents give thermodynamically disfavored reactions.

  14. Life cycle analysis within pharmaceutical process optimization and intensification: case study of active pharmaceutical ingredient production.

    PubMed

    Ott, Denise; Kralisch, Dana; Denčić, Ivana; Hessel, Volker; Laribi, Yosra; Perrichon, Philippe D; Berguerand, Charline; Kiwi-Minsker, Lioubov; Loeb, Patrick

    2014-12-01

    As the demand for new drugs is rising, the pharmaceutical industry faces the quest of shortening development time, and thus, reducing the time to market. Environmental aspects typically still play a minor role within the early phase of process development. Nevertheless, it is highly promising to rethink, redesign, and optimize process strategies as early as possible in active pharmaceutical ingredient (API) process development, rather than later at the stage of already established processes. The study presented herein deals with a holistic life-cycle-based process optimization and intensification of a pharmaceutical production process targeting a low-volume, high-value API. Striving for process intensification by transfer from batch to continuous processing, as well as an alternative catalytic system, different process options are evaluated with regard to their environmental impact to identify bottlenecks and improvement potentials for further process development activities.

  15. SECRETLY ECCENTRIC: THE GIANT PLANET AND ACTIVITY CYCLE OF GJ 328

    SciTech Connect

    Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Boss, Alan P.

    2013-09-10

    We announce the discovery of a {approx}2 Jupiter-mass planet in an eccentric 11 yr orbit around the K7/M0 dwarf GJ 328. Our result is based on 10 years of radial velocity (RV) data from the Hobby-Eberly and Harlan J. Smith telescopes at McDonald Observatory, and from the Keck Telescope at Mauna Kea. Our analysis of GJ 328's magnetic activity via the Na I D features reveals a long-period stellar activity cycle, which creates an additional signal in the star's RV curve with amplitude 6-10 m s{sup -1}. After correcting for this stellar RV contribution, we see that the orbit of the planet is more eccentric than suggested by the raw RV data. GJ 328b is currently the most massive, longest-period planet discovered around a low-mass dwarf.

  16. Olfactory bulb units - Activity correlated with inhalation cycles and odor quality.

    NASA Technical Reports Server (NTRS)

    Macrides, F.; Chorover, S. L.

    1972-01-01

    Single olfactory bulb units were studied in two macrosmatic species of rodents under conditions intended to preserve the cyclical stimulation which normally accompanies nasal breathing. Patterns of unit activity related to the inhalation cycle were observed in all animals, often in the absence of specific stimuli, and could not be explained in simple mechanical terms. Distinctive changes in these patterns occurred in response to certain odors, and were generally independent of changes in the overall firing frequency. These findings indicate that a change in the overall firing frequency of unit discharges is neither a necessary nor sufficient measure of responsiveness to odors in the rodent olfactory bulb, and that stimulus-specific temporal distributions of unit firing may be involved in olfacto-endocrine activities.

  17. Secretly Eccentric: The Giant Planet and Activity Cycle of GJ 328

    NASA Astrophysics Data System (ADS)

    Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Boss, Alan P.

    2013-09-01

    We announce the discovery of a ~2 Jupiter-mass planet in an eccentric 11 yr orbit around the K7/M0 dwarf GJ 328. Our result is based on 10 years of radial velocity (RV) data from the Hobby-Eberly and Harlan J. Smith telescopes at McDonald Observatory, and from the Keck Telescope at Mauna Kea. Our analysis of GJ 328's magnetic activity via the Na I D features reveals a long-period stellar activity cycle, which creates an additional signal in the star's RV curve with amplitude 6-10 m s-1. After correcting for this stellar RV contribution, we see that the orbit of the planet is more eccentric than suggested by the raw RV data. GJ 328b is currently the most massive, longest-period planet discovered around a low-mass dwarf.

  18. Magnetic Tilts in Sunspot Groups and Active regions in the Cycle 23 obtained from the Solar Feature Catalogues

    NASA Astrophysics Data System (ADS)

    Zharkov, S. I.; Zharkova, V. V.; Bianda, M.; Cartesi, S.

    We compare a few methods for calculation of magnetic tilts in active regions using using the automated sunspot group classification from the Solar Feature Catalogues http solar inf brad ac uk for 1996-2005 The best performing methods were applied to investigate the statistical variations of magnetic field tilt in sunspot groups and their relation to the total magnetic field contained in sunspots during different phases of the solar cycle 23 The classification results are compared with the similar research for the cycle 22 and the specifics on the cycle 23 is discussed The results are also tested against the existing solar dynamo models and their applicability for the solar activity forecast

  19. Dry/Wet cycles change the activity and population dynamics of methanotrophs in rice field soil.

    PubMed

    Ma, Ke; Conrad, Ralf; Lu, Yahai

    2013-08-01

    The methanotrophs in rice field soil are crucial in regulating the emission of methane. Drainage substantially reduces methane emission from rice fields. However, it is poorly understood how drainage affects microbial methane oxidation. Therefore, we analyzed the dynamics of methane oxidation rates, composition (using terminal restriction fragment length polymorphism [T-RFLP]), and abundance (using quantitative PCR [qPCR]) of methanotroph pmoA genes (encoding a subunit of particulate methane monooxygenase) and their transcripts over the season and in response to alternate dry/wet cycles in planted paddy field microcosms. In situ methane oxidation accounted for less than 15% of total methane production but was enhanced by intermittent drainage. The dry/wet alternations resulted in distinct effects on the methanotrophic communities in different soil compartments (bulk soil, rhizosphere soil, surface soil). The methanotrophic communities of the different soil compartments also showed distinct seasonal dynamics. In bulk soil, potential methanotrophic activity and transcription of pmoA were relatively low but were significantly stimulated by drainage. In contrast, however, in the rhizosphere and surface soils, potential methanotrophic activity and pmoA transcription were relatively high but decreased after drainage events and resumed after reflooding. While type II methanotrophs dominated the communities in the bulk soil and rhizosphere soil compartments (and to a lesser extent also in the surface soil), it was the pmoA of type I methanotrophs that was mainly transcribed under flooded conditions. Drainage affected the composition of the methanotrophic community only minimally but strongly affected metabolically active methanotrophs. Our study revealed dramatic dynamics in the abundance, composition, and activity of the various type I and type II methanotrophs on both a seasonal and a spatial scale and showed strong effects of dry/wet alternation cycles, which enhanced

  20. Activity levels of bats and katydids in relation to the lunar cycle.

    PubMed

    Lang, Alexander B; Kalko, Elisabeth K V; Römer, Heinrich; Bockholdt, Cecile; Dechmann, Dina K N

    2006-01-01

    Animals are exposed to many conflicting ecological pressures, and the effect of one may often obscure that of another. A likely example of this is the so-called "lunar phobia" or reduced activity of bats during full moon. The main reason for lunar phobia was thought to be that bats adjust their activity to avoid predators. However, bats can be prey, but many are carnivorous and therefore predators themselves. Thus, they are likely to be influenced by prey availability as well as predation risk. We investigated the activity patterns of the perch-hunting Lophostoma silvicolum and one of its main types of prey, katydids, to assess the influence of the former during different phases of the lunar cycle on a gleaning insectivorous bat. To avoid sampling bias, we used sound recordings and two different capture methods for the katydids, as well as video monitoring and radio-telemetry for the bats. Both, bats and katydids were significantly more active during the dark periods associated with new moon compared to bright periods around the full moon. We conclude that foraging activity of L. silvicolum is probably influenced by prey availability to a large extent and argue that generally the causes of lunar phobia are species-specific.

  1. Continuous activity and no cycling of clock genes in the Antarctic midge during the polar summer.

    PubMed

    Kobelkova, Alena; Goto, Shin G; Peyton, Justin T; Ikeno, Tomoko; Lee, Richard E; Denlinger, David L

    2015-10-01

    The extreme seasonal shifts of day length in polar regions, ranging from constant light in the summer to constant darkness in the winter, pose an intriguing environment for probing activity rhythms and the functioning of circadian clocks. Here, we monitor locomotor activity during the summer on the Antarctic Peninsula and under laboratory conditions, as well as the accompanying patterns of clock gene expression in the Antarctic midge, the only insect endemic to Antarctica. Larvae and adults are most active during the warmest portion of the day, but at a constant temperature they remain continuously active regardless of the photoregime, and activity also persists in constant darkness. The canonical clock genes period, timeless, Clock, and vrille are expressed in the head but we detected no cycling of expression in either the field or under diverse photoregimes in the laboratory. The timekeeping function of the clock has possibly been lost, enabling the midge to opportunistically exploit the unpredictable availability of permissive thermal conditions for growth, development, and reproduction during the short summer in Antarctica.

  2. Flux-tube geometry and solar wind speed during an activity cycle

    NASA Astrophysics Data System (ADS)

    Pinto, R. F.; Brun, A. S.; Rouillard, A. P.

    2016-07-01

    Context. The solar wind speed at 1 AU shows cyclic variations in latitude and in time which reflect the evolution of the global background magnetic field during the activity cycle. It is commonly accepted that the terminal (asymptotic) wind speed in a given magnetic flux-tube is generally anti-correlated with its total expansion ratio, which motivated the definition of widely used semi-empirical scaling laws relating one to the other. In practice, such scaling laws require ad hoc corrections (especially for the slow wind in the vicinities of streamer/coronal hole boundaries) and empirical fits to in situ spacecraft data. A predictive law based solely on physical principles is still missing. Aims: We test whether the flux-tube expansion is the controlling factor of the wind speed at all phases of the cycle and at all latitudes (close to and far from streamer boundaries) using a very large sample of wind-carrying open magnetic flux-tubes. We furthermore search for additional physical parameters based on the geometry of the coronal magnetic field which have an influence on the terminal wind flow speed. Methods: We use numerical magneto-hydrodynamical simulations of the corona and wind coupled to a dynamo model to determine the properties of the coronal magnetic field and of the wind velocity (as a function of time and latitude) during a whole 11-yr activity cycle. These simulations provide a large statistical ensemble of open flux-tubes which we analyse conjointly in order to identify relations of dependence between the wind speed and geometrical parameters of the flux-tubes which are valid globally (for all latitudes and moments of the cycle). Results: Our study confirms that the terminal (asymptotic) speed of the solar wind depends very strongly on the geometry of the open magnetic flux-tubes through which it flows. The total flux-tube expansion is more clearly anti-correlated with the wind speed for fast rather than for slow wind flows, and effectively controls the

  3. Hilbert-Huang transform analysis of periodicities in the last two solar activity cycles

    NASA Astrophysics Data System (ADS)

    Kolotkov, D. Y.; Broomhall, A.-M.; Nakariakov, V. M.

    2015-08-01

    We investigated periodicities associated with the last two-and-a-half solar activity cycles with the novel Hilbert-Huang transform (HHT) method. Raw data signals of five different observational proxies: the 10.7 cm radio flux intensity, the helioseismic frequency shift, and the sunspot area signals recorded from the whole solar disc, and separately from the Northern and Southern hemispheres, were expanded into a set of intrinsic modes with the ensemble empirical mode decomposition technique. Instant and mean periods of each empirical mode were obtained with the use of the Hilbert transform applied independently to each separate mode. The periodicities were allocated to three distinct groups: short-term variations (with periods shorter than 0.5 yr), quasi-biennial oscillations (with typical periods from 0.5 yr to 3.9 yr), and longer periodicities, e.g. such as the 11 yr cycle. All periodicities detected in the examined solar cycles 22-24 are consistent with the well-known results found in the earlier solar epochs. We have demonstrated that the HHT method is a good tool for characterizing periodicities in the helioseismic data, which are necessarily relatively limited in terms of their time resolution. Periodicities obtained using the helioseismic data are, nevertheless, consistent with those found in other proxies. Since helioseismic oscillations are sensitive to the solar interior, this indicates that the behaviour of surface and atmospheric magnetic activity reflects that of the Sun's internal magnetic field. All identified intrinsic modes are seen to have clear amplitude modulation highly correlated with the 11 yr cycle. This amplitude modulation is most pronounced in the short-period modes. The short-term periodicities were found to be multiples of the shortest period, of 25 d. This ordering of the short-term periodicities is consistent with the previous findings. Signatures of the north-south asymmetry were detected in the individual hemisphere sunspot area

  4. Cell cycle arrest and apoptosis, two alternative mechanisms for PMKT2 killer activity.

    PubMed

    Santos, Antonio; Alonso, Alejandro; Belda, Ignacio; Marquina, Domingo

    2013-01-01

    Pichia membranifaciens CYC 1086 secretes a unique 30kDa killer toxin (PMKT2) that inhibits a variety of spoilage yeasts and fungi of agronomical interest. The cytocidal effect of PMKT2 on Saccharomyces cerevisiae cells was studied. Metabolic events associated with the loss of S. cerevisiae viability caused by PMKT2 were qualitatively identical to those reported for K28 killer toxin activity, but different to those reported for PMKT. At higher doses, none of the cellular events accounting for the action of PMKT, the killer toxin secreted by P. membranifaciens CYC 1106, was observed for PMKT2. Potassium leakage, sodium influx and the decrease of intracellular pH were not among the primary effects of PMKT2. We report here that this protein is unable to form ion-permeable channels in liposome membranes, suggesting that channel formation is not the mechanism of cytotoxic action of PMKT2. Nevertheless, flow cytometry studies have revealed a cell cycle arrest at an early S-phase with an immature bud and pre-replicated 1n DNA content. By testing the sensitivity of cells arrested at different stages in the cell cycle, we hoped to identify the execution point for lethality more precisely. Cells arrested at the G1-phase by α-factor or arrested at G2-phase by the spindle poison methyl benzimidazol-2-yl-carbamate (MBC) were protected against the toxin. Cells released from the arrest in both cases were killed by PMKT2 at a similar rate. Nevertheless, cells released from MBC-arrest were able to grow for a short time, and then viability dropped rapidly. These findings suggest that cells released from G2-phase are initially able to divide, but die in the presence of PMKT2 after initiating the S-phase in a new cycle, adopting a terminal phenotype within that cycle. By contrast, low doses of PMKT and PMKT2 were able to generate the same cellular response. The evidence presented here shows that treating yeast with low doses of PMKT2 leads to the typical membranous, cytoplasmic

  5. Neighborhood walkability and active travel (walking and cycling) in New York City.

    PubMed

    Freeman, Lance; Neckerman, Kathryn; Schwartz-Soicher, Ofira; Quinn, James; Richards, Catherine; Bader, Michael D M; Lovasi, Gina; Jack, Darby; Weiss, Christopher; Konty, Kevin; Arno, Peter; Viola, Deborah; Kerker, Bonnie; Rundle, Andrew G

    2013-08-01

    Urban planners have suggested that built environment characteristics can support active travel (walking and cycling) and reduce sedentary behavior. This study assessed whether engagement in active travel is associated with neighborhood walkability measured for zip codes in New York City. Data were analyzed on engagement in active travel and the frequency of walking or biking ten blocks or more in the past month, from 8,064 respondents to the New York City 2003 Community Health Survey (CHS). A neighborhood walkability scale that measures: residential, intersection, and subway stop density; land use mix; and the ratio of retail building floor area to retail land area was calculated for each zip code. Data were analyzed using zero-inflated negative binomial regression incorporating survey sample weights and adjusting for respondents' sociodemographic characteristics. Overall, 44 % of respondents reported no episodes of active travel and among those who reported any episode, the mean number was 43.2 episodes per month. Comparing the 75th to the 25th percentile of zip code walkability, the odds ratio for reporting zero episodes of active travel was 0.71 (95 % CI 0.61, 0.83) and the exponentiated beta coefficient for the count of episodes of active travel was 1.13 (95 % CI 1.06, 1.21). Associations between lower walkability and reporting zero episodes of active travel were significantly stronger for non-Hispanic Whites as compared to non-Hispanic Blacks and to Hispanics and for those living in higher income zip codes. The results suggest that neighborhood walkability is associated with higher engagement in active travel.

  6. Population based, controlled study of behavioural problems and psychiatric disorders in low birthweight children at 11 years of age

    PubMed Central

    Elgen, I; Sommerfelt, K; Markestad, T

    2002-01-01

    Objective: To evaluate the risk of long term behavioural problems and psychiatric disorders associated with being born with low birth weight. Design/study groups: A population based, controlled follow up study at 11 years of age of 130 low birthweight (LBW) children weighing less than 2000 g at birth who were without major handicaps, and a random sample of 131 normal birthweight (NBW) children born at term weighing over 3000 g. Main outcome measures: Validated questionnaires addressing behaviour completed by mothers and teachers and child evaluation by child psychiatrist using a semistructured interview. Results: Behavioural problems, as defined by abnormal scores on more than four of 32 measures, were found in 40% of LBW children compared with 7% of NBW children (odds ratio (OR) 8.2, 95% confidence interval (CI) 3 to 25, p = 0001). A psychiatric disorder was diagnosed in 27% of the LBW children compared with 9% of the NBW children (OR 3.1, 95% CI 1.5 to 6.5, p = 0.001). The LBW children were more often inattentive, had social problems, and low self esteem. None of the pre-, neo-, or peri-natal variables in the LBW group were statistically significant predictors of behavioural outcomes or the presence of psychiatric disorders. Behavioural problems and psychiatric disorders were as common in those with birth weight less than 1500 g as those with birth weight 1500–2000 g. Conclusion: An increased risk of behavioural problems and psychiatric disorders persists in LBW adolescents. PMID:12193521

  7. Case report: Successful treatment of recurrent chordoma and bilateral pulmonary metastases following an 11-year disease-free period

    PubMed Central

    Erkmen, Cherie P.; Barth, Richard J.; Raman, Vignesh

    2014-01-01

    INTRODUCTION Chordomas are rare but aggressive tumors due to local recurrence and distant metastases. They originate commonly in the sphenooccipital and sacrococcygeal regions, and metastasize to the lungs, bone, skin, liver, and lymph nodes. They occur more frequently in men and people over the age of 40. PRESENTATION OF CASE A 28 year-old female presented with sacrococcygeal chordoma for which she received wide local excision and adjuvant radiation therapy. She enjoyed an unusual disease-free survival for 11 years until a routine surveillance scan of the pelvis identified local recurrence. Further work up revealed bilateral pulmonary metastases. She underwent local excision of the recurrent tumor and video-assisted thoracoscopic (VATS) wedge resection of pulmonary metastases. She also received adjuvant radiation therapy to the recurrent resection bed. Two years later, she remains free of disease and symptoms. DISCUSSION Chordomas are commonly insensitive to chemotherapy and radiation, making surgery the most successful therapeutic modality. However, there are few guidelines on the surveillance and treatment of recurrent chordoma. We report success with aggressive surgical resection of recurrence and metastasis as well as adjuvant radiation therapy. CONCLUSION The prolonged survival of our patient underscores the importance of (1) aggressive surgical resection of chordoma, whether primary, recurrent, or metastatic, with adjuvant radiation therapy, (2) minimization of surgical seeding of tumor, and (3) diligent cancer surveillance. PMID:24907541

  8. Diagnosis and Treatment of Odontogenic Cutaneous Sinus Tracts in an 11-Year-Old Boy: A Case Report.

    PubMed

    Chen, Ke; Liang, Yun; Xiong, Huacui

    2016-05-01

    Odontogenic cutaneous sinus tracts (OCSTs) are generally primarily misdiagnosed and inappropriately treated by virtue of their rarity and the absence of dental symptoms. Accurate diagnosis and treatment and the elimination of the source of infection can reduce the incidence of complications and relieve the pain of the patient.In this case report, we present the case of an 11-year-old patient with an apparent abscess but an unobvious draining sinus tract in his left cheek. Intraorally, a glass-ionomer-cement filling on the occlusal surface of the left mandibular first molar (tooth 36) was noted. Radiographic examination revealed a radiopaque mass inside the crown and pulp chamber and an irregular, radiolucent periapical lesion surrounding the distal root apex. He was diagnosed with an OCTS secondary to a periapical abscess of tooth 36. Precise root canal therapy (RCT) and chronic granuloma debridement was performed; 6 months later, the abscess and sinus had healed completely, and the periapical lesion had resolved.Odontogenic cutaneous sinus tracts are uncommon in the clinic. This case report reminds us of the significance of OCSTs and provides some implications for their diagnosis and treatment. PMID:27196471

  9. Acute pancreatitis secondary to hyperlipidemia in an 11-year-old girl: A case report and review of literature

    PubMed Central

    Bălănescu, NR; Topor, L; Ulici, A; Djendov, FB

    2013-01-01

    We report the case of an 11-year-old female with acute pancreatitis, and review the literature highlighting the presenting symptoms and signs, laboratory tests, and investigational tools that helped in the establishment of a correct diagnosis. First, the patient presented to a regional hospital reporting abdominal pain, vomiting and liquid stool. She was admitted with the diagnosis of acute surgical abdomen and underwent surgery. Upon admission in our department, laboratory findings showed high values for total lipids = 2600 mg/dL and triglycerides 1200 mg/dL. Abdominal ultrasound revealed a pancreas with a small enlargement of the head (19 mm), and with a heterogeneous structure of the parenchyma. Abdominal computed tomography showed small left pleural collection and a high-dimensioned pancreas, particularly at the head, with heterogeneous structure, and peripancreatic collections. The patient was treated by fasting, gastric decompression by nasogastric tube, and intravenous antibiotherapy followed by antialgic and antispasticity treatment. Time of the patient’s first feeding was after the 7th day of hospitalization. The patient was discharged in a very good condition after 22 days of hospitalization. PMID:23599811

  10. A Case of an 11-year-old With Cough, Diarrhea, and Findings of Concern in His Lungs and Spleen.

    PubMed

    Darby, John B; Rees, Chris A; Bocchini, Claire E; Cruz, Andrea T; Kellermayer, Richard; Finegold, Milton J; Barlow, Sarah E

    2016-03-01

    This is the case of a previously healthy, 11-year-old male of Indian descent who presented to the emergency department with a 2-month history of nausea, vomiting, diarrhea, fatigue, cough, and 7-lb weight loss. Acutely, he developed 5 days of fever as high as 39.4°C. He had a remote travel history to the Middle East. On physical examination, he was febrile and tachycardic, was thin but otherwise had a normal examination. His inflammatory markers were elevated: erythrocyte sedimentation rate was 93 mm/hour and his C-reactive protein was 25.4 mg/L. A complete blood count revealed a white blood cell count of 17,000 × 10(3)/µL with increased bands. His hemoglobin level was 8.8 g/dL with a mean corpuscular volume of 81 fl. Platelets were 556 × 10(3)/µL. A chest radiograph was concerning for a cavitary lung lesion and an abdominal ultrasound revealed multiple hypoechoic lesions in his spleen. Our panel of experts reviews his case and examines the workup of this patient with diverse symptoms and focal findings on chest radiograph and abdominal ultrasound. PMID:26908705

  11. [Expression of the emotions in the drawing of a man by the child from 5 to 11 years of age].

    PubMed

    Brechet, Claire; Picard, Delphine; Baldy, René

    2007-06-01

    This study examines the development of children's ability to express emotions in their human figure drawing. Sixty children of 5, 8, and 11 years were asked to draw "a man," and then a "sad", "happy," "angry" and "surprised" man. Expressivity of the drawings was assessed by means of two procedures: a limited choice and a free labelling procedure. Emotionally expressive drawings were then evaluated in terms of the number and the type of graphic cues that were used to express emotion. It was found that children are able to depict happiness and sadness at 8, anger and surprise at 11. With age, children use increasingly numerous and complex graphic cues for each emotion (i.e., facial expression, body position, and contextual cues). Graphic cues for facial expression (e.g., concave mouth, curved eyebrows, wide opened eyes) share strong similarities with specific "action units" described by Ekman and Friesen (1978) in their Facial Action Coding System. Children's ability to depict emotion in their human figure drawing is discussed in relation to perceptual, conceptual, and graphic abilities.

  12. Short normal children and environmental disadvantage: a longitudinal study of growth and cognitive development from 4 to 11 years.

    PubMed

    Dowdney, L; Skuse, D; Morris, K; Pickles, A

    1998-10-01

    The aim of this investigation was to follow up a sample of exceptionally short but medically healthy children, and a normal comparison group, previously studied at 4 years of age. They lived in an inner-city area which was, on objective criteria, seriously disadvantaged in socioeconomic terms. When first seen at 4 years, cases were significantly impaired in cognitive abilities relative to comparisons, although firstborns were much less severely affected. Of the original 46 cases, 45 were assessed again at 11 years. Most continued to live in the same geographical area. Case children remained exceptionally short, even when parental stature was taken into account, although a degree of catch-up had occurred. One third had special educational needs, and a similar proportion had been referred for speech therapy. Verbal and nonverbal cognitive skills of both case and comparison children had, on the whole, changed little and group differences persisted. In conclusion, short normal children from socioeconomically disadvantaged backgrounds are at high risk of educational failure at elementary school. PMID:9804034

  13. Effect of ball mass on dribble, pass, and pass reception in 9-11-year-old boys' basketball.

    PubMed

    Arias, José L; Argudo, Francisco M; Alonso, José I

    2012-09-01

    The objective of the study was to analyze the effect of ball mass on dribble, pass, and pass reception in real game situations in 9-11-year-old boys' basketball. Participants were 54 boys identified from six federated teams. The independent variable was ball mass, and dependent variables were number of dribbles, passes, and pass receptions. Three situations were established in which the participants played four games with each of the following: (a) regulation ball (485 g, 69-71 cm), (b) ball of smaller mass (440 g, 69-71 cm), and (c) ball of greater mass (540 g, 69-71 cm). Four observers recorded data from observing game videos using a computerized register instrument. Participants executed more dribbles, passes, and pass receptions with the 440g ball when compared to the regulation (p < .05) and 540g ball (p < .01). Reduction of ball mass seems to have enabled the children to go from paying attention to aspects related to ball handling to aspects of game interpretation.

  14. Forecasting life: a study of activity cycles in low-mass stars: lessons from long-term stellar light curves.

    PubMed

    Kafka, Stella

    2012-06-01

    Magnetic activity cycles are indirect traces of magnetic fields and can provide an insight on the nature and action of stellar dynamos and stellar magnetic activity. This, in turn, can determine local space weather and activity effects on stellar habitable zones. Using photometric monitoring of low-mass stars, we study the presence and properties of their magnetic activity cycles. We introduce long-term light curves of our sample stars, and discuss the properties of the observed trends, especially at spectral types where stars are fully convective (later than M3).

  15. The activity of Krebs cycle enzymes in the visual analyzer of rats in the norm and under stress.

    PubMed

    Lutsenko, N S; Yakushev, V S

    1993-01-01

    Higher activity of the NAD-dependent dehydrogenases of the tricarboxylic acid cycle (TAC) is observed in the optic retina, and of FAD-dependent dehydrogenases in the occipital lobes of the brain, in the visual analyzer of intact rats. The influence of stress using Desiderato's method induces a compensatory increase in the activity of succinate dehydrogenase. Acute stress induces a change in the regulation of the activity of the TAC dehydrogenases, assessed on the basis of the reaction to functional load. The animals' remaining in the dark following stress promotes the restoration of the activity of the TAC cycle to the normal level. PMID:8413911

  16. Long-period intensity pulsations in the solar corona during activity cycle 23

    NASA Astrophysics Data System (ADS)

    Auchère, F.; Bocchialini, K.; Solomon, J.; Tison, E.

    2014-03-01

    We report on the detection (10σ) of 917 events of long-period (3 to 16 h) intensity pulsations in the 19.5 nm passband of the SOHO Extreme ultraviolet Imaging Telescope. The data set spans from January 1997 to July 2010, i.e. the entire solar cycle 23 and the beginning of cycle 24. The events can last for up to six days and have relative amplitudes up to 100%. About half of the events (54%) are found to happen in active regions, and 50% of these have been visually associated with coronal loops. The remaining 46% are localized in the quiet Sun. We performed a comprehensive analysis of the possible instrumental artefacts and we conclude that the observed signal is of solar origin. We discuss several scenarios that could explain the main characteristics of the active region events. The long periods and the amplitudes observed rule out any explanation in terms of magnetohydrodynamic waves. Thermal non-equilibrium could produce the right periods, but it fails to explain all the observed properties of coronal loops and the spatial coherence of the events. We propose that moderate temporal variations of the heating term in the energy equation, so as to avoid a thermal non-equilibrium state, could be sufficient to explain those long-period intensity pulsations. The large number of detections suggests that these pulsations are common in active regions. This would imply that the measurement of their properties could provide new constraints on the heating mechanisms of coronal loops. Movies are available in electronic form at http://www.aanda.org

  17. Active sulfur cycling by diverse mesophilic and thermophilic microorganisms in terrestrial mud volcanoes of Azerbaijan.

    PubMed

    Green-Saxena, A; Feyzullayev, A; Hubert, C R J; Kallmeyer, J; Krueger, M; Sauer, P; Schulz, H-M; Orphan, V J

    2012-12-01

    Terrestrial mud volcanoes (TMVs) represent geochemically diverse habitats with varying sulfur sources and yet sulfur cycling in these environments remains largely unexplored. Here we characterized the sulfur-metabolizing microorganisms and activity in four TMVs in Azerbaijan. A combination of geochemical analyses, biological rate measurements and molecular diversity surveys (targeting metabolic genes aprA and dsrA and SSU ribosomal RNA) supported the presence of active sulfur-oxidizing and sulfate-reducing guilds in all four TMVs across a range of physiochemical conditions, with diversity of these guilds being unique to each TMV. The TMVs varied in potential sulfate reduction rates (SRR) by up to four orders of magnitude with highest SRR observed in sediments where in situ sulfate concentrations were highest. Maximum temperatures at which SRR were measured was 60°C in two TMVs. Corresponding with these trends in SRR, members of the potentially thermophilic, spore-forming, Desulfotomaculum were detected in these TMVs by targeted 16S rRNA analysis. Additional sulfate-reducing bacterial lineages included members of the Desulfobacteraceae and Desulfobulbaceae detected by aprA and dsrA analyses and likely contributing to the mesophilic SRR measured. Phylotypes affiliated with sulfide-oxidizing Gamma- and Betaproteobacteria were abundant in aprA libraries from low sulfate TMVs, while the highest sulfate TMV harboured 16S rRNA phylotypes associated with sulfur-oxidizing Epsilonproteobacteria. Altogether, the biogeochemical and microbiological data indicate these unique terrestrial habitats support diverse active sulfur-cycling microorganisms reflecting the in situ geochemical environment.

  18. Active sulfur cycling by diverse mesophilic and thermophilic microorganisms in terrestrial mud volcanoes of Azerbaijan.

    PubMed

    Green-Saxena, A; Feyzullayev, A; Hubert, C R J; Kallmeyer, J; Krueger, M; Sauer, P; Schulz, H-M; Orphan, V J

    2012-12-01

    Terrestrial mud volcanoes (TMVs) represent geochemically diverse habitats with varying sulfur sources and yet sulfur cycling in these environments remains largely unexplored. Here we characterized the sulfur-metabolizing microorganisms and activity in four TMVs in Azerbaijan. A combination of geochemical analyses, biological rate measurements and molecular diversity surveys (targeting metabolic genes aprA and dsrA and SSU ribosomal RNA) supported the presence of active sulfur-oxidizing and sulfate-reducing guilds in all four TMVs across a range of physiochemical conditions, with diversity of these guilds being unique to each TMV. The TMVs varied in potential sulfate reduction rates (SRR) by up to four orders of magnitude with highest SRR observed in sediments where in situ sulfate concentrations were highest. Maximum temperatures at which SRR were measured was 60°C in two TMVs. Corresponding with these trends in SRR, members of the potentially thermophilic, spore-forming, Desulfotomaculum were detected in these TMVs by targeted 16S rRNA analysis. Additional sulfate-reducing bacterial lineages included members of the Desulfobacteraceae and Desulfobulbaceae detected by aprA and dsrA analyses and likely contributing to the mesophilic SRR measured. Phylotypes affiliated with sulfide-oxidizing Gamma- and Betaproteobacteria were abundant in aprA libraries from low sulfate TMVs, while the highest sulfate TMV harboured 16S rRNA phylotypes associated with sulfur-oxidizing Epsilonproteobacteria. Altogether, the biogeochemical and microbiological data indicate these unique terrestrial habitats support diverse active sulfur-cycling microorganisms reflecting the in situ geochemical environment. PMID:23116231

  19. Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells.

    PubMed

    Lemieszek, Marta Kinga; Cardoso, Claudia; Ferreira Milheiro Nunes, Fernando Hermínio; Ramos Novo Amorim de Barros, Ana Isabel; Marques, Guilhermina; Pożarowski, Piotr; Rzeski, Wojciech

    2013-04-25

    The use of biologically active compounds isolated from edible mushrooms against cancer raises global interest. Anticancer properties are mainly attributed to biopolymers including mainly polysaccharides, polysaccharopeptides, polysaccharide proteins, glycoproteins and proteins. In spite of the fact that Boletus edulis is one of the widely occurring and most consumed edible mushrooms, antitumor biopolymers isolated from it have not been exactly defined and studied so far. The present study is an attempt to extend this knowledge on molecular mechanisms of their anticancer action. The mushroom biopolymers (polysaccharides and glycoproteins) were extracted with hot water and purified by anion-exchange chromatography. The antiproliferative activity in human colon adenocarcinoma cells (LS180) was screened by means of MTT and BrdU assays. At the same time fractions' cytotoxicity was examined on the human colon epithelial cells (CCD 841 CoTr) by means of the LDH assay. Flow cytometry and Western blotting were applied to cell cycle analysis and protein expression involved in anticancer activity of the selected biopolymer fraction. In vitro studies have shown that fractions isolated from Boletus edulis were not toxic against normal colon epithelial cells and in the same concentration range elicited a very prominent antiproliferative effect in colon cancer cells. The best results were obtained in the case of the fraction designated as BE3. The tested compound inhibited cancer cell proliferation which was accompanied by cell cycle arrest in the G0/G1-phase. Growth inhibition was associated with modulation of the p16/cyclin D1/CDK4-6/pRb pathway, an aberration of which is a critical step in the development of many human cancers including colon cancer. Our results indicate that a biopolymer BE3 from Boletus edulis possesses anticancer potential and may provide a new therapeutic/preventive option in colon cancer chemoprevention.

  20. Antimicrobial Resistance among Respiratory Pathogens in Spain: Latest Data and Changes over 11 Years (1996-1997 to 2006-2007)▿

    PubMed Central

    Pérez-Trallero, Emilio; Martín-Herrero, Jose E.; Mazón, Ana; García-Delafuente, Celia; Robles, Purificación; Iriarte, Victor; Dal-Ré, Rafael; García-de-Lomas, Juan

    2010-01-01

    A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of ≥2 μg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a β-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLSB) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), β-lactamase production (from 25.7% to 15.7%), and β-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLSB was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes. PMID:20439616

  1. Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007).

    PubMed

    Pérez-Trallero, Emilio; Martín-Herrero, Jose E; Mazón, Ana; García-Delafuente, Celia; Robles, Purificación; Iriarte, Victor; Dal-Ré, Rafael; García-de-Lomas, Juan

    2010-07-01

    A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of > or = 2 microg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a beta-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLS(B)) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), beta-lactamase production (from 25.7% to 15.7%), and beta-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLS(B) was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes.

  2. Humans Transforming the Water Cycle: Community-Based Activities in Hydrologic Synthesis

    NASA Astrophysics Data System (ADS)

    Vorosmarty, C. J.; Frolking, S.; Green, M.

    2007-12-01

    This paper describes a newly convened effort to design and execute synthesis studies in hydrology. We focus on an emerging view that human activities are affecting strongly the basic character of the water cycle, through a myriad of processes including water abstraction and flow diversion, land cover change, pollution, destruction of aquatic biodiversity, and climate change. A major scientific challenge is to understand how these changes manifest themselves and if they generate synergistic impacts across the different scales. Our primary synthesis goal is to quantify widespread alteration of hydrologic systems over local-to-regional domains focusing on the Northeast corridor of the United States over a 500-yr period (1600 to 2100). This is a region bearing sharp gradients in climate, land and water management and emblematic of pressures on water resources across the nation. This science agenda will be advanced through the activities of a consolidated Working Group (WG), which will study Regional Watersheds, Hydromorphology, and Continental Processes. The effort expands activities first consolidated under CUAHSI, and welcomes several new members who have led major CUAHSI, NSF, National Academy, regional, national, and international community activities. Our WG maintains cross-linked sub-groups framework to provide focus and unity of purpose. A project implementation design will be presented, including research, education, and outreach efforts.

  3. Seasonal and Solar Cycle Variation of the Martian Ionosphere from Nine Years of MARSIS Active Sounding

    NASA Astrophysics Data System (ADS)

    Morgan, David D.; Withers, Paul; Gurnett, Donald; Nemec, Frantisek

    This past June, we celebrated nine years of continuous operation by MARSIS, the radar sounder on the Mars Express spacecraft, in orbit around Mars since Christmas of 2003. The copious data from this instrument in its Active Ionospheric Sounding mode has been used in numerous scientific endeavors to generate empirical models of the Martian ionosphere. The full ionospheric profiles gleaned from analysis of these data are ideal for this kind of effort. Out of more than 170,000 traces collected, we have selected only about 10%, deemed to be of the best quality, and that can be fit to a Chapman layer function. We now have nine years, or 4-3/4 Mars years, worth of ionospheric traces. In addition to sampling nearly five years of seasonal variation, these nine years of data also represent 80% of a normal solar cycle. Therefore, in this work we shall analyze ionospheric traces with the objective of determining variation of atmospheric and ionospheric parameters such as the neutral atmospheric scale height, ionospheric peak altitude, and ionospheric peak density as they vary with the solar cycle and the change in season.

  4. Effects of cycle duration of an external electrostatic field on anammox biomass activity.

    PubMed

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m(3)/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application. PMID:26794647

  5. Effects of cycle duration of an external electrostatic field on anammox biomass activity

    NASA Astrophysics Data System (ADS)

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m3/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application.

  6. Earthquake cycle associated with active strike slip faults in central Panamá

    NASA Astrophysics Data System (ADS)

    Rick, Bennett; Spinler, Joshua C.; Compton, Kathleen; Rockwell, Thomas K.; Gath, Eldon

    2013-04-01

    The rigidity of the Panamá Isthmus is currently under debate, with important implications for seismic hazards to the Panamá Canal and Panamá City. Whereas Panamá has traditionally been described as a non-deforming microplate caught between a number of larger tectonic plates, new paleoseismic data collected at a limited number of trench sites in association with the ongoing expansion of the Panamá Canal may challenge the validity of the rigid microplate hypothesis. Crustal velocities from a new, ~100 km aperture, 5-station continuous GPS network constructed across the Rio Gatún, Limón, and Pedro Miguel fault zones confirm that these fault zones are active, forming a system of faults that traverse central Panamá in close proximity to the Panamá Canal and Panamá City. However, the slip rates inferred from these new geodetic data are lower than the geologic rates when using an elastic halfspace model. Differences among previous geodetic investigations, which concluded that Panamá is rigid, and the geological slip rate estimates are explained by earthquake cycle effects associated with long recurrence intervals relative to lower crust and upper mantle Maxwell relaxation times. Late in the earthquake cycle the geodetic strain field is broadly distributed, giving the false appearance of low seismic hazards.

  7. Effects of cycle duration of an external electrostatic field on anammox biomass activity

    PubMed Central

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m3/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application. PMID:26794647

  8. Detection of anomalous reactor activity using antineutrino count evolution over the course of a reactor cycle

    NASA Astrophysics Data System (ADS)

    Bulaevskaya, Vera; Bernstein, Adam

    2011-06-01

    This paper analyzes the sensitivity of antineutrino count rate measurements to changes in the fissile content of civil power reactors. Such measurements may be useful in IAEA reactor safeguards applications. We introduce a hypothesis testing procedure to identify statistically significant differences between the antineutrino count rate evolution of a standard "baseline" fuel cycle and that of an anomalous cycle, in which plutonium is removed and replaced with an equivalent fissile worth of uranium. The test would allow an inspector to detect anomalous reactor activity, or to positively confirm that the reactor is operating in a manner consistent with its declared fuel inventory and power level. We show that with a reasonable choice of detector parameters, the test can detect replacement of 82 kg of plutonium in 90 days with 95% probability, while controlling the false positive rate at 5%. We show that some improvement on this level of sensitivity may be obtained by various means, including use of the method in conjunction with existing reactor safeguards methods. We also identify a necessary and sufficient minimum daily antineutrino count rate and a maximum tolerable background rate to achieve the quoted sensitivity, and list examples of detectors in which such rates have been attained.

  9. Long term determinants of functional decline of mobility: an 11-year follow-up of 5464 adults of late middle aged and elderly.

    PubMed

    Lêng, Chhian Hūi; Wang, Jung-Der

    2013-01-01

    This confirmatory study aims at investigating the long term determinants of mobility limitation among late middle aged and elderly in a physically less active population. Five thousand four hundred and sixty-four participants aged 50-97 in 1996 enrolled the Taiwan Longitudinal Study on Aging (TLSA) for four waves of interview during 11 years. Social and health-related determinants were collected in each interview. Mobility limitation was enquired level of difficulty in eight movement tasks, including lifting 11kg weight, squatting, running 20-30m, standing for 15min, walking 200-300m, climbing up two to three floors, raising arms up and grasping with fingers. According to the mixed models with repeated measurements, more frequent gardening and longer time for each exercise predicted subsequent better mobility function in Taiwanese elderly while controlling demographics and current comorbidities. The protective effect of gardening was robust in all models. Frequent alcohol consumption was harmful to future mobility function, but less as harmful when participants aged. Besides, the depression-related somatic complaints were predictive to future mobility limitation among those without limitation at baseline. It shall be worthy to explore the dosage as well as the mechanism of these protective factors, especially the most significant but the least explored factor, gardening. Additionally, efforts should be made to understand the relationship between depression-related somatic complaints and mobility decline and so as the relevant interventions. PMID:23608344

  10. Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle.

    PubMed

    Zhelev, Zhivko; Aoki, Ichio; Gadjeva, Veselina; Nikolova, Biliana; Bakalova, Rumiana; Saga, Tsuneo

    2013-04-01

    The experience in free radical biology and medicine shows the crucial role of redox signalling in carcinogenesis. The cells and tissues of healthy mammals are characterised by a low level of reactive oxygen species (ROS) and some constant (reference) level of reducing equivalents. Increasing of ROS above the critical level provokes genomic instability. The present study describes universal methodology for direct imaging of tissue redox activity in carcinogenesis, which allows a differentiation of cancer development from normal condition. The experiments were conducted on: neuroblastoma-bearing mice; colon cancer-bearing mice; and healthy mice. The tissue redox activity was visualised in vivo by nitroxide-enhanced magnetic resonance imaging (MRI) on anesthetised animals. The method is based on nitroxide redox cycle, coupled with appearance/disappearance of MRI signal. The half-life (τ1/2) of nitroxide-enhanced MRI signal in the respective tissue was used as a diagnostic marker. The study provides direct evidence that healthy and cancer-bearing mammalian tissues are characterised by different redox activities - a basis for cancer diagnosis. The tissues (cancer and 'normal') of cancer-bearing mammals were characterised by a long-lived MRI signal (τ1/2>14 min), indicating a high oxidative activity. The tissues of healthy organism were characterised by a short-lived MRI signal (τ1/2=1-3 min), indicating a high reducing activity. The study shows that tissue redox activity is a sensing platform for imaging of cancer using nitroxide-enhanced MRI. It also suggests that 'normal' tissues of cancer-bearing organism are susceptible to oxidative damage.

  11. Predictions of the onset of mini ice age in the 25th solar cycle

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv

    2016-07-01

    Predictions of the ir-regularty in the 11 year heartbeat of the sun due to asyncronous of the two layered dynamo effect would result in mini ice age as in the Maunder minimum.The onset of this event is expected in the begining of 25th solar cycle and would go to its maximum in the 26th solar cycle.The minimum temperature is expected in 2028 due to the fall of solar activity by 60 % termed as solar hibernation.The predictions are based on the observations obtained by the Royal Greenwich observatory since 1874. Keywords: Dynamo effect,munder minimum,Solar hybernation

  12. Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological aging of Saccharomyces cerevisiae. Compensatory role of succinate oxidation.

    PubMed

    Samokhvalov, V; Ignatov, V; Kondrashova, M

    2004-01-01

    We investigated oxidative processes in mitochondria of Saccharomyces cerevisiae grown on ethanol in the course of chronological aging. We elaborated a model of chronological aging that avoids the influence of exhaustion of medium, as well as the accumulation of toxic metabolites during aging. A decrease in total respiration of cells and, even more, of the contribution of respiration coupled with ATP-synthesis was observed during aging. Aging is also related with the decrease of the contribution of malonate-insensitive respiration. Activities of citrate-synthase (CS), alpha-ketoglutarate dehydrogenase (KGDH) and malate dehydrogenase (MDH) were threefold decreased. The activity of NADP-dependent isocitrate dehydrogenase (NADP-ICDH) decreased more significantly, while the activity of NAD-dependent isocitrate dehydrogenase (NAD-ICDH) fell even greater, being completely inactivated on the third week of aging. In contrast, succinate dehydrogenase (SDH), enzymes of glyoxylate cycle (GCL) (isocitrate lyase (ICL) and malate synthase (MLS)), and enzymes of ethanol oxidation (alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH)), were activated by 50% or more. The behavior of oxidative enzymes and metabolic pathways are apparently inherent to a more viable, long-lived cells in population, selected in the course of chronological aging. This selection allows cells to reveal the mechanism of their higher viability as caused by shunting of complete Krebs cycle by glyoxylate cycle, with a concomitant increased rate of the most efficient energy source, namely succinate formation and oxidation. Thiobarbituric-reactive species (TAR species) increased during aging. We supposed that to be the immediate cause of damage of a part of yeast population. These data show that a greater succinate contribution to respiration in more active cells is a general property of yeast and animal tissues.

  13. THE ACOUSTIC CUTOFF FREQUENCY OF THE SUN AND THE SOLAR MAGNETIC ACTIVITY CYCLE

    SciTech Connect

    Jimenez, A.; Palle, P. L.; Garcia, R. A.

    2011-12-20

    The acoustic cutoff frequency-the highest frequency for acoustic solar eigenmodes-is an important parameter of the solar atmosphere as it determines the upper boundary of the p-mode resonant cavities. At frequencies beyond this value, acoustic disturbances are no longer trapped but are traveling waves. Interference among them gives rise to higher-frequency peaks-the pseudomodes-in the solar acoustic spectrum. The pseudomodes are shifted slightly in frequency with respect to p-modes, making possible the use of pseudomodes to determine the acoustic cutoff frequency. Using data from the GOLF and VIRGO instruments on board the Solar and Heliospheric Observatory spacecraft, we calculate the acoustic cutoff frequency using the coherence function between both the velocity and intensity sets of data. By using data gathered by these instruments during the entire lifetime of the mission (1996 until the present), a variation in the acoustic cutoff frequency with the solar magnetic activity cycle is found.

  14. 14C activity and global carbon cycle changes over the past 50,000 years.

    PubMed

    Hughen, K; Lehman, S; Southon, J; Overpeck, J; Marchal, O; Herring, C; Turnbull, J

    2004-01-01

    A series of 14C measurements in Ocean Drilling Program cores from the tropical Cariaco Basin, which have been correlated to the annual-layer counted chronology for the Greenland Ice Sheet Project 2 (GISP2) ice core, provides a high-resolution calibration of the radiocarbon time scale back to 50,000 years before the present. Independent radiometric dating of events correlated to GISP2 suggests that the calibration is accurate. Reconstructed 14C activities varied substantially during the last glacial period, including sharp peaks synchronous with the Laschamp and Mono Lake geomagnetic field intensity minimal and cosmogenic nuclide peaks in ice cores and marine sediments. Simulations with a geochemical box model suggest that much of the variability can be explained by geomagnetically modulated changes in 14C production rate together with plausible changes in deep-ocean ventilation and the global carbon cycle during glaciation.

  15. Solar neutrinos, solar flares, solar activity cycle and the proton decay

    NASA Technical Reports Server (NTRS)

    Raychaudhuri, P.

    1985-01-01

    It is shown that there may be a correlation between the galactic cosmic rays and the solar neutrino data, but it appears that the neutrino flux which may be generated during the large solar cosmic ray events cannot in any way effect the solar neutrino data in Davis experiment. Only initial stage of mixing between the solar core and solar outer layers after the sunspot maximum in the solar activity cycle can explain the higher (run number 27 and 71) of solar neutrino data in Davis experiment. But solar flare induced atmospheric neutrino flux may have effect in the nucleon decay detector on the underground. The neutrino flux from solar cosmic rays may be a useful guide to understand the background of nucleon decay, magnetic monopole search, and the detection of neutrino flux in sea water experiment.

  16. RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

    PubMed Central

    Ogawa, Daisuke; Abe, Kiyomi; Miyao, Akio; Kojima, Mikiko; Sakakibara, Hitoshi; Mizutani, Megumi; Morita, Haruka; Toda, Yosuke; Hobo, Tokunori; Sato, Yutaka; Hattori, Tsukaho; Hirochika, Hirohiko; Takeda, Shin

    2011-01-01

    Plant growth and development are sustained by continuous cell division in the meristems, which is perturbed by various environmental stresses. For the maintenance of meristematic functions, it is essential that cell division be coordinated with cell differentiation. However, it is unknown how the proliferative activities of the meristems and the coordination between cell division and differentiation are maintained under stressful conditions. Here we show that a rice protein, RSS1, whose stability is controlled by cell cycle phases, contributes to the vigour of meristematic cells and viability under salinity conditions. These effects of RSS1 are exerted by regulating the G1–S transition, possibly through an interaction of RSS1 with protein phosphatase 1, and are mediated by the phytohormone, cytokinin. RSS1 is conserved widely in plant lineages, except eudicots, suggesting that RSS1-dependent mechanisms might have been adopted in specific lineages during the evolutionary radiation of angiosperms. PMID:21505434

  17. Background solar irradiance spectrum at high and low phases of the solar activity cycle

    NASA Astrophysics Data System (ADS)

    Vázquez Ramió, H.; Roca Cortés, T.; Régulo, C.

    2002-12-01

    Two data series of disk integrated solar irradiance, taken by the Variability of the solar IRradiance and Gravity Oscillations (VIRGO) experiment on board the Solar and Heliospheric Observatory (SoHO) mission, corresponding to epochs of minimum and maximum solar activity have been analysed in order to study the background signal of the associated power spectra. We fit the most apparent convective structures that appear at low frequencies in the spectrum as well as non-periodic components. We aim to compare the results found in the three observed bands (centered in λ=402nm, λ=500nm and λ=862nm) as well as to find dependences of the non-periodic convective structures parameters with the solar cycle.

  18. OBSERVATIONAL ASPECTS OF THE THREE-DIMENSIONAL CORONAL STRUCTURE OVER A SOLAR ACTIVITY CYCLE

    SciTech Connect

    Morgan, Huw; Habbal, Shadia Rifai

    2010-02-10

    Solar rotational tomography is applied to almost eleven years of Large Angle Spectrometric Coronagraph C2/Solar and Heliospheric Observatory data, revealing for the first time the behavior of the large-scale coronal density structures, also known as streamers, over almost a full solar activity cycle. This study gives an overview of the main results of this project. (1) Streamers are most often shaped as extended, narrow plasma sheets. The sheets can be extremely narrow at times (<=0.14 x 10{sup 6} km at 4 R{sub sun}). This is over twice their heliocentric angular thickness at 1 AU. (2) At most times outside the height of solar maximum, there are two separate stable large helmet streamer belts extending from mid-latitudes (in both north and south). At solar minimum, the streamers converge and join near the equator, giving the impression of a single large helmet streamer. Outside of solar minimum, the two streamers do not join, forming separate high-density sheets in the extended corona (one in the north, another in the south). At solar maximum, streamers rise radially from their source regions, while during the ascending and descending activity phases, streamers are skewed toward the equator. (3) For most of the activity cycle, streamers share the same latitudinal extent as filaments on the disk, showing that large-scale stable streamers are closely linked to the same large-scale photospheric magnetic configuration, which give rise to large filaments. (4) The poleward footpoints of the streamers are often above crown polar filaments and the equatorial footpoints are above filaments or active regions (or above the photospheric neutral lines which underlie these structures). The high-density structures arising from the equatorial active regions either rise and form the equatorial footpoints of mid-latitude quiescent streamers, or form unstable streamers at the equator, not connected to the quiescent streamer structure at higher latitude (so there are often three

  19. Activation of the methylation cycle in cells reprogrammed into a stem cell-like state

    PubMed Central

    Bosch-Barrera, Joaquim; Alarcón, Tomás; Joven, Jorge; Menendez, Javier A.

    2015-01-01

    Generation of induced pluripotent stem (iPS) cells and cancer biogenesis share similar metabolic switches. Most studies have focused on how the establishment of a cancer-like glycolytic phenotype is necessary for the optimal routing of somatic cells for achieving stemness. However, relatively little effort has been dedicated towards elucidating how one-carbon (1C) metabolism is retuned during acquisition of stem cell identity. Here we used ultra-high pressure liquid chromatography coupled to an electrospray ionization source and a triple-quadrupole mass spectrometer [UHPLC-ESI-QqQ-MS/MS] to quantitatively examine the methionine/folate bi-cyclic 1C metabolome during nuclear reprogramming of somatic cells into iPS cells. iPS cells optimize the synthesis of the universal methyl donor S-adenosylmethionine (SAM), apparently augment the ability of the redox balance regulator NADPH in SAM biosynthesis, and greatly increase their methylation potential by triggering a high SAM:S-adenosylhomocysteine (SAH) ratio. Activation of the methylation cycle in iPS cells efficiently prevents the elevation of homocysteine (Hcy), which could alter global DNA methylation and induce mitochondrial toxicity, oxidative stress and inflammation. In this regard, the methyl donor choline is also strikingly accumulated in iPS cells, suggesting perhaps an overactive intersection of the de novo synthesis of choline with the methionine-Hcy cycle. Activation of methylogenesis and maintenance of an optimal SAM:Hcy ratio might represent an essential function of 1C metabolism to provide a labile pool of methyl groups and NADPH-dependent redox products required for successfully establishing and maintaining an embryonic-like DNA methylation imprint in stem cell states. PMID:26909364

  20. Metaproteogenomics reveals the soil microbial communities active in nutrient cycling processes under different tree species

    NASA Astrophysics Data System (ADS)

    Keiblinger, Katharina Maria; Masse, Jacynthe; Zühlke, Daniela; Riedel, Katharina; Zechmeister-Boltenstern, Sophie; Prescott, Cindy E.; Grayston, Sue

    2016-04-01

    Tree species exert strong effects on microbial communities in litter and soil and may alter rates of soil processes fundamental to nutrient cycling and carbon fluxes (Prescott and Grayston 2013). However, the influence of tree species on decomposition processes are still contradictory and poorly understood. An understanding of the mechanisms underlying plant influences on soil processes is important for our ability to predict ecosystem response to altered global/environmental conditions. In order to link microbial community structure and function to forest-floor nutrient cycling processes, we sampled forest floors under western redcedar (Thuja plicata), Douglas-fir (Pseudotsuga menziesii) and Sitka spruce (Picea sitchensis) grown in nutrient-poor sites in common garden experiments on Vancouver island (Canada). We measured forest-floor total N, total C, initial NH4+ and NO3‑ concentrations, DOC, Cmic and Nmic. Gross rates of ammonification and NH4+ consumption were measured using the 15N pool-dilution method. Organic carbon quality was assessed through FTIR analyses. Microbial community structure was analysed by a metaproteogenomic approach using 16S and ITS amplification and sequencing with MiSeq platform. Proteins were extracted and peptides characterized via LC-MS/MS on a Velos Orbitrap to assess the active microbial community. Different microbial communities were active under the three tree species and variation in process rates were observed and will be discussed. This research provides new insights on microbial processes during organic matter decomposition. The metaproteogenomic approach enables us to investigate these changes with respect to possible effects on soil C-storage at even finer taxonomic resolution.

  1. Electrocortical activity is coupled to gait cycle phase during treadmill walking.

    PubMed

    Gwin, Joseph T; Gramann, Klaus; Makeig, Scott; Ferris, Daniel P

    2011-01-15

    Recent findings suggest that human cortex is more active during steady-speed unperturbed locomotion than previously thought. However, techniques that have been used to image the brain during locomotion lack the temporal resolution necessary to assess intra-stride cortical dynamics. Our aim was to determine if electrocortical activity is coupled to gait cycle phase during steady-speed human walking. We used electroencephalography (EEG), motion capture, and a force-measuring treadmill to record brain and body dynamics while eight healthy young adult subjects walked on a treadmill. Infomax independent component analysis (ICA) parsed EEG signals into maximally independent component (IC) processes representing electrocortical sources, muscle sources, and artifacts. We calculated a spatially fixed equivalent current dipole for each IC using an inverse modeling approach, and clustered electrocortical sources across subjects by similarities in dipole locations and power spectra. We then computed spectrograms for each electrocortical source that were time-locked to the gait cycle. Electrocortical sources in the anterior cingulate, posterior parietal, and sensorimotor cortex exhibited significant (p<0.05) intra-stride changes in spectral power. During the end of stance, as the leading foot was contacting the ground and the trailing foot was pushing off, alpha- and beta-band spectral power increased in or near the left/right sensorimotor and dorsal anterior cingulate cortex. Power increases in the left/right sensorimotor cortex were more pronounced for contralateral limb push-off (ipsilateral heel-strike) than for ipsilateral limb push-off (contralateral heel-strike). Intra-stride high-gamma spectral power changes were evident in anterior cingulate, posterior parietal, and sensorimotor cortex. These data confirm cortical involvement in steady-speed human locomotion. Future applications of these techniques could provide critical insight into the neural mechanisms of movement

  2. Metaproteogenomics reveals the soil microbial communities active in nutrient cycling processes under different tree species

    NASA Astrophysics Data System (ADS)

    Keiblinger, Katharina Maria; Masse, Jacynthe; Zühlke, Daniela; Riedel, Katharina; Zechmeister-Boltenstern, Sophie; Prescott, Cindy E.; Grayston, Sue

    2016-04-01

    Tree species exert strong effects on microbial communities in litter and soil and may alter rates of soil processes fundamental to nutrient cycling and carbon fluxes (Prescott and Grayston 2013). However, the influence of tree species on decomposition processes are still contradictory and poorly understood. An understanding of the mechanisms underlying plant influences on soil processes is important for our ability to predict ecosystem response to altered global/environmental conditions. In order to link microbial community structure and function to forest-floor nutrient cycling processes, we sampled forest floors under western redcedar (Thuja plicata), Douglas-fir (Pseudotsuga menziesii) and Sitka spruce (Picea sitchensis) grown in nutrient-poor sites in common garden experiments on Vancouver island (Canada). We measured forest-floor total N, total C, initial NH4+ and NO3- concentrations, DOC, Cmic and Nmic. Gross rates of ammonification and NH4+ consumption were measured using the 15N pool-dilution method. Organic carbon quality was assessed through FTIR analyses. Microbial community structure was analysed by a metaproteogenomic approach using 16S and ITS amplification and sequencing with MiSeq platform. Proteins were extracted and peptides characterized via LC-MS/MS on a Velos Orbitrap to assess the active microbial community. Different microbial communities were active under the three tree species and variation in process rates were observed and will be discussed. This research provides new insights on microbial processes during organic matter decomposition. The metaproteogenomic approach enables us to investigate these changes with respect to possible effects on soil C-storage at even finer taxonomic resolution.

  3. E-cigarette use and intentions to smoke among 10-11-year-old never-smokers in Wales

    PubMed Central

    Moore, Graham F; Littlecott, Hannah J; Moore, Laurence; Ahmed, Nilufar; Holliday, Jo

    2016-01-01

    Background E-cigarettes are seen by some as offering harm reduction potential, where used effectively as smoking cessation devices. However, there is emerging international evidence of growing use among young people, amid concerns that this may increase tobacco uptake. Few UK studies examine the prevalence of e-cigarette use in non-smoking children or associations with intentions to smoke. Methods A cross-sectional survey of year 6 (10–11-year-old) children in Wales. Approximately 1500 children completed questions on e-cigarette use, parental and peer smoking, and intentions to smoke. Logistic regression analyses among never smoking children, adjusted for school-level clustering, examined associations of smoking norms with e-cigarette use, and of e-cigarette use with intentions to smoke tobacco within the next 2 years. Results Approximately 6% of year 6 children, including 5% of never smokers, reported having used an e-cigarette. By comparison to children whose parents neither smoked nor used e-cigarettes, children were most likely to have used an e-cigarette if parents used both tobacco and e-cigarettes (OR=3.40; 95% CI 1.73 to 6.69). Having used an e-cigarette was associated with intentions to smoke (OR=3.21; 95% CI 1.66 to 6.23). While few children reported that they would smoke in 2 years’ time, children who had used an e-cigarette were less likely to report that they definitely would not smoke tobacco in 2 years’ time and were more likely to say that they might. Conclusions E-cigarettes represent a new form of childhood experimentation with nicotine. Findings are consistent with a hypothesis that children use e-cigarettes to imitate parental and peer smoking behaviours, and that e-cigarette use is associated with weaker antismoking intentions. PMID:25535293

  4. Present-day kinematics and fault slip rates in eastern Iran, derived from 11 years of GPS data

    NASA Astrophysics Data System (ADS)

    Walpersdorf, A.; Manighetti, I.; Mousavi, Z.; Tavakoli, F.; Vergnolle, M.; Jadidi, A.; Hatzfeld, D.; Aghamohammadi, A.; Bigot, A.; Djamour, Y.; Nankali, H.; Sedighi, M.

    2014-02-01

    We analyze new GPS data spanning 11 years at 92 stations in eastern Iran. We use these data to analyze the present-day kinematics and the slip rates on most seismogenic faults in eastern Iran. The east Lut, west Lut, Kuhbanan, Anar, Dehshir, and Doruneh faults are confirmed as the major faults and are found to currently slip laterally at 5.6 ± 0.6, 4.4 ± 0.4, 3.6 ± 1.3, 2.0 ± 0.7, 1.4 ± 0.9, and 1.3 ± 0.8 mm/yr, respectively. Slip is right-lateral on the ~NS striking east Lut, west Lut, Kuhbanan, Anar, and Dehshir faults and left-lateral on the ~EW Doruneh fault. The ~NS faults slice the eastern Iranian crust into five blocks that are moving northward at 6-13 mm/yr with respect to the stable Afghan crust at the eastern edge of the collision zone. The collective behavior of the ~NS faults might thus allow the Arabian promontory to impinge northward into the Eurasian crust. The ~NS faults achieve additional NS shortening by rotating counterclockwise in the horizontal plane, at current rates up to 0.8°/Ma. Modeling the GPS and available geological data with a block rotation model suggests that the rotations have been going on at a similar rate (1 ± 0.4°/Ma) over the last 12 Ma. We identify large strains at the tips of the rotating east Lut, west Lut, and Kuhbanan faults, which we suspect to be responsible for the important historical and instrumental seismicity in those zones.

  5. A mechanistic soil biogeochemistry model with explicit representation of microbial and macrofaunal activities and nutrient cycles

    NASA Astrophysics Data System (ADS)

    Fatichi, Simone; Manzoni, Stefano; Or, Dani; Paschalis, Athanasios

    2016-04-01

    The potential of a given ecosystem to store and release carbon is inherently linked to soil biogeochemical processes. These processes are deeply connected to the water, energy, and vegetation dynamics above and belowground. Recently, it has been advocated that a mechanistic representation of soil biogeochemistry require: (i) partitioning of soil organic carbon (SOC) pools according to their functional role; (ii) an explicit representation of microbial dynamics; (iii) coupling of carbon and nutrient cycles. While some of these components have been introduced in specialized models, they have been rarely implemented in terrestrial biosphere models and tested in real cases. In this study, we combine a new soil biogeochemistry model with an existing model of land-surface hydrology and vegetation dynamics (T&C). Specifically the soil biogeochemistry component explicitly separates different litter pools and distinguishes SOC in particulate, dissolved and mineral associated fractions. Extracellular enzymes and microbial pools are explicitly represented differentiating the functional roles of bacteria, saprotrophic and mycorrhizal fungi. Microbial activity depends on temperature, soil moisture and litter or SOC stoichiometry. The activity of macrofauna is also modeled. Nutrient dynamics include the cycles of nitrogen, phosphorous and potassium. The model accounts for feedbacks between nutrient limitations and plant growth as well as for plant stoichiometric flexibility. In turn, litter input is a function of the simulated vegetation dynamics. Root exudation and export to mycorrhiza are computed based on a nutrient uptake cost function. The combined model is tested to reproduce respiration dynamics and nitrogen cycle in few sites where data were available to test plausibility of results across a range of different metrics. For instance in a Swiss grassland ecosystem, fine root, bacteria, fungal and macrofaunal respiration account for 40%, 23%, 33% and 4% of total belowground

  6. IVF cycle cost estimation using Activity Based Costing and Monte Carlo simulation.

    PubMed

    Cassettari, Lucia; Mosca, Marco; Mosca, Roberto; Rolando, Fabio; Costa, Mauro; Pisaturo, Valerio

    2016-03-01

    The Authors present a new methodological approach in stochastic regime to determine the actual costs of an healthcare process. The paper specifically shows the application of the methodology for the determination of the cost of an Assisted reproductive technology (ART) treatment in Italy. The reason of this research comes from the fact that deterministic regime is inadequate to implement an accurate estimate of the cost of this particular treatment. In fact the durations of the different activities involved are unfixed and described by means of frequency distributions. Hence the need to determine in addition to the mean value of the cost, the interval within which it is intended to vary with a known confidence level. Consequently the cost obtained for each type of cycle investigated (in vitro fertilization and embryo transfer with or without intracytoplasmic sperm injection), shows tolerance intervals around the mean value sufficiently restricted as to make the data obtained statistically robust and therefore usable also as reference for any benchmark with other Countries. It should be noted that under a methodological point of view the approach was rigorous. In fact it was used both the technique of Activity Based Costing for determining the cost of individual activities of the process both the Monte Carlo simulation, with control of experimental error, for the construction of the tolerance intervals on the final result.

  7. Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.

    PubMed

    Deneke, Victoria E; Melbinger, Anna; Vergassola, Massimo; Di Talia, Stefano

    2016-08-22

    Embryos of most metazoans undergo rapid and synchronous cell cycles following fertilization. While diffusion is too slow for synchronization of mitosis across large spatial scales, waves of Cdk1 activity represent a possible process of synchronization. However, the mechanisms regulating Cdk1 waves during embryonic development remain poorly understood. Using biosensors of Cdk1 and Chk1 activities, we dissect the regulation of Cdk1 waves in the Drosophila syncytial blastoderm. We show that Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. Using mathematical modeling and surgical ligations, we demonstrate a fundamental distinction between S phase Cdk1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagate as passive phase waves. Our findings show that in Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events.

  8. IVF cycle cost estimation using Activity Based Costing and Monte Carlo simulation.

    PubMed

    Cassettari, Lucia; Mosca, Marco; Mosca, Roberto; Rolando, Fabio; Costa, Mauro; Pisaturo, Valerio

    2016-03-01

    The Authors present a new methodological approach in stochastic regime to determine the actual costs of an healthcare process. The paper specifically shows the application of the methodology for the determination of the cost of an Assisted reproductive technology (ART) treatment in Italy. The reason of this research comes from the fact that deterministic regime is inadequate to implement an accurate estimate of the cost of this particular treatment. In fact the durations of the different activities involved are unfixed and described by means of frequency distributions. Hence the need to determine in addition to the mean value of the cost, the interval within which it is intended to vary with a known confidence level. Consequently the cost obtained for each type of cycle investigated (in vitro fertilization and embryo transfer with or without intracytoplasmic sperm injection), shows tolerance intervals around the mean value sufficiently restricted as to make the data obtained statistically robust and therefore usable also as reference for any benchmark with other Countries. It should be noted that under a methodological point of view the approach was rigorous. In fact it was used both the technique of Activity Based Costing for determining the cost of individual activities of the process both the Monte Carlo simulation, with control of experimental error, for the construction of the tolerance intervals on the final result. PMID:24752546

  9. Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.

    PubMed

    Deneke, Victoria E; Melbinger, Anna; Vergassola, Massimo; Di Talia, Stefano

    2016-08-22

    Embryos of most metazoans undergo rapid and synchronous cell cycles following fertilization. While diffusion is too slow for synchronization of mitosis across large spatial scales, waves of Cdk1 activity represent a possible process of synchronization. However, the mechanisms regulating Cdk1 waves during embryonic development remain poorly understood. Using biosensors of Cdk1 and Chk1 activities, we dissect the regulation of Cdk1 waves in the Drosophila syncytial blastoderm. We show that Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. Using mathematical modeling and surgical ligations, we demonstrate a fundamental distinction between S phase Cdk1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagate as passive phase waves. Our findings show that in Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events. PMID:27554859

  10. Effect of different aerodynamic time trial cycling positions on muscle activation and crank torque.

    PubMed

    Fintelman, D M; Sterling, M; Hemida, H; Li, F-X

    2016-05-01

    To reduce air resistance, time trial cyclists and triathletes lower their torso angle. The aim of this study was to investigate the effect of lowering time trial torso angle positions on muscle activation patterns and crank torque coordination. It was hypothesized that small torso angles yield a forward shift of the muscle activation timing and crank torque. Twenty-one trained cyclists performed three exercise bouts at 70% maximal aerobic power in a time trial position at three different torso angles (0°, 8°, and 16°) at a fixed cadence of 85 rpm. Measurements included surface electromyography, crank torques and gas exchange. A significant increase in crank torque range and forward shift in peak torque timing was found at smaller torso angles. This relates closely with the later onset and duration of the muscle activation found in the gluteus maximus muscle. Torso angle effects were only observed in proximal monoarticular muscles. Moreover, all measured physiological variables (oxygen consumption, breathing frequency, minute ventilation) were significantly increased with lowering torso angle and hence decreased the gross efficiency. The findings provide support for the notion that at a cycling intensity of 70% maximal aerobic power, the aerodynamic gains outweigh the physiological/biomechanical disadvantages in trained cyclists.

  11. Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

    PubMed Central

    McCormack, Ryan M; Lyapichev, Kirill; Olsson, Melissa L; Podack, Eckhard R; Munson, George P

    2015-01-01

    Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapid redistribution of Perforin-2 and is essential for its bactericidal activity. Enteric pathogens such as Yersinia pseudotuberculosis and enteropathogenic Escherichia coli disarm host cells by injecting cell cycle inhibiting factors (Cifs) into mammalian cells to deamidate the ubiquitin-like protein NEDD8. Because CRL activity is dependent upon NEDD8, Cif blocks ubiquitin dependent trafficking of Perforin-2 and thus, its bactericidal activity. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria. DOI: http://dx.doi.org/10.7554/eLife.06505.001 PMID:26418746

  12. Evolution and Flare Activity of δ-Sunspots in Cycle 23

    NASA Astrophysics Data System (ADS)

    Takizawa, K.; Kitai, R.

    2015-07-01

    The emergence and magnetic evolution of solar active regions (ARs) of βγδ-type, which are known to be highly flare-productive, were studied with SOHO/MDI data in Cycle 23. We selected 31 ARs that can be observed from their birth phase as unbiased samples for our study. From the analysis of the magnetic topology (twist and writhe), we obtained the following results: i) Emerging βγδ ARs can be classified into three topological types as quasi-β, writhed, and top-to-top. ii) Of these, the writhed and top-to-top types tend to show high flare activity. iii) As the signs of twist and writhe agree with each other in most cases of the writhed type (12 cases out of 13), we propose a magnetic model in which the emerging flux regions in a βγδAR are not separated, but are united as a single structure below the solar surface. iv) Almost all the writhed-type ARs have downward knotted structures in the middle part of the magnetic flux tube. This is probably the essential property of βγδ ARs. v) The flare activity of βγδ ARs is highly correlated not only with the sunspot area, but also with the magnetic complexity. vi) We suggest that there is a possible scaling-law between the flare index and the maximum umbral area.

  13. Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure-activity relationship study.

    PubMed

    Ho, Si-Han Sherman; Sim, Mei-Yi; Yee, Wei-Loong Sherman; Yang, Tianming; Yuen, Shyi-Peng John; Go, Mei-Lin

    2015-11-01

    The anticancer agent YM155 is widely investigated as a specific survivin suppressant. More recently, YM155 was found to induce DNA damage and this has raised doubts as to whether survivin is its primary target. In an effort to assess the contribution of DNA damage to the anticancer activity of YM155, several analogs were prepared and evaluated for antiproliferative activity on malignant cells, participation in DNA intercalation and free radical generation by redox cycling. The intact positively charged scaffold was found to be essential for antiproliferative activity and intercalation but was less critical for redox cycling where the minimal requirement was a pared down bicyclic quinone. Side chain requirements at the N(1) and N(3) positions of the scaffold were more alike for redox cycling and intercalation than antiproliferative activity, underscoring yet again, the limited structural overlaps for these activities. Furthermore, antiproliferative activities were poorly correlated to DNA intercalation and redox cycling. Potent antiproliferative activity (IC50 9-23 nM), exceeding that of YM155, was found for a minimally substituted methyl analog AB7. Like YM155 and other dioxonaphthoimidazoliums, AB7 was a modest DNA intercalator but with weak redox cycling activity. Thus, the capacity of this scaffold to inflict direct DNA damage leading to cell death may not be significant and YM155 should not be routinely classified as a DNA damaging agent.

  14. Effects of Cycling Conditions of Active Material From Discharged Ni Positive Plates Studied by Inelastic Neutron Scattering Spectroscopy

    NASA Technical Reports Server (NTRS)

    Eckert, Juergen; Varma, Ravi; Diebolt, Lisa; Reid, Margaret

    1998-01-01

    The objectives of this presentation are: identify atomic-level signatures of electrochemical activity of the active material on the Ni positive plates of Ni-H2 batteries, relate finding to cycling conditions and histories, and develop INS spectroscopy as a non-destructive testing technique for the evaluation of Ni-positive plates of Ni-H2 batteries.

  15. The influence of fixation delay on mitotic activity and flow cytometric cell cycle variables.

    PubMed

    Bergers, E; Jannink, I; van Diest, P I; Cuesta, M A; Meyer, S; van Mourik, J C; Baak, J P

    1997-01-01

    Proliferation variables such as mitotic activity and the percentage of S-phase cells have been shown to be of prognostic value in many tumors, especially in breast cancer. However, some studies reported a decrease in mitotic activity caused by delay in fixation of the tissue. In contrast, other studies showed that the identifiability of mitotic figures decreases after fixation delay, but the total number of mitotic figures and also the percentage of S-phase cells remain unchanged. Most studies have been done on small numbers of experimental tumors, thus introducing the risk of selection bias. The aim of this study was to reinvestigate the influence of fixation delay on mitotic activity and cell cycle variables assessed by flow cytometry in an adequate number of resected human tissues to reach firmer conclusions. Resection specimens of 19 and 21 cases, respectively, for the mitotic activity estimate and the flow cytometric percentage of S-phase calculation were collected directly from the operating theater using lung, breast, and intestinal cancers and normal intestinal mucosa. The tissues were cut in pieces, and from each specimen, pieces were fixed in 4% buffered formaldehyde (for mitosis counting) as well as snap frozen (for flow cytometry) immediately after excision, as well as after a fixation delay of 1, 2, 4, 6, 8, 18, and 24 hours. Moreover, during the fixation delay, one series from each specimen was kept in the refrigerator and the second at room temperature. Thus, a total of 304 (19 X 16) and 336 (21 X 16) specimens were investigated for the mitotic activity estimate and the percentage of S-phase cells calculation, respectively. With regard to the estimation of the mitotic activity, both clear and doubtful mitotic figures were registered separately, obtaining an "uncorrected" and "corrected" (for doubtful mitotic figures) mitotic activity estimate. The percentage of S-phase cells was obtained by cell cycle analysis of flow cytometric DNA-histograms. The

  16. The benefit of artificial oocyte activation is dependent on the fertilization rate in a previous treatment cycle.

    PubMed

    Montag, Markus; Köster, Maria; van der Ven, Katrin; Bohlen, Ulrike; van der Ven, Hans

    2012-05-01

    Following intracytoplasmic sperm injection (ICSI), some patients present low or zero fertilization rates. Artificial oocyte activation has been proposed as a suitable means to overcome this problem. This study applied artificial oocyte activation in patient cohorts with a history of no fertilization (0%, group 1), fertilization between 1 and 29% (group 2) or fertilization between 30 and 50% (group 3) in initial ICSI cycles. In the following treatment cycles, oocytes were activated after ICSI using calcium ionophore. Fertilization, pregnancy and take-home baby rates were compared with the previous cycle without activation. In group 1, fertilization rate was 41.6%, embryos for transfer were available in 82.1% of cycles, giving a clinical pregnancy rate of 18.8% and take-home baby rate of 12.8%. In group 2, despite a lower transfer rate (87.9% versus 100%, P<0.05), there were higher fertilization and clinical pregnancy rates (44.4% versus 19.3% and 31.4% versus 12.8%, respectively, P<0.05) and take-home baby rate was 24.1% versus 12.8%. In group 3, fertilization rates differed (56.1% versus 36.8%; P<0.001) but all other parameters were similar. Artificial oocyte activation has great potential especially in patients showing compromised fertilization rates below 30% after standard ICSI. Following intracytoplasmic sperm injection (ICSI), some patients present very low or even zero fertilization rates after ICSI. Artificial oocyte activation has been proposed as a suitable means to overcome this problem. We applied artificial oocyte activation in patients which presented a history either no fertilization, fertilization between 0 and 30% or fertilization between 30 and 50% in initial ICSI cycles. In the following treatment cycles, oocytes were activated after ICSI using a calcium ionophore. Fertilization, pregnancy and take-home baby rates were compared to the previous cycle without activation. For the groups with previously 0% or 1-29% fertilization, we noted higher

  17. Breakpoints in ventilation, cerebral and muscle oxygenation, and muscle activity during an incremental cycling exercise

    PubMed Central

    Racinais, Sebastien; Buchheit, Martin; Girard, Olivier

    2014-01-01

    The aim of this study was to locate the breakpoints of cerebral and muscle oxygenation and muscle electrical activity during a ramp exercise in reference to the first and second ventilatory thresholds. Twenty-five cyclists completed a maximal ramp test on an electromagnetically braked cycle-ergometer with a rate of increment of 25 W/min. Expired gazes (breath-by-breath), prefrontal cortex and vastus lateralis (VL) oxygenation [Near-infrared spectroscopy (NIRS)] together with electromyographic (EMG) Root Mean Square (RMS) activity for the VL, rectus femoris (RF), and biceps femoris (BF) muscles were continuously assessed. There was a non-linear increase in both cerebral deoxyhemoglobin (at 56 ± 13% of the exercise) and oxyhemoglobin (56 ± 8% of exercise) concomitantly to the first ventilatory threshold (57 ± 6% of exercise, p > 0.86, Cohen's d < 0.1). Cerebral deoxyhemoglobin further increased (87 ± 10% of exercise) while oxyhemoglobin reached a plateau/decreased (86 ± 8% of exercise) after the second ventilatory threshold (81 ± 6% of exercise, p < 0.05, d > 0.8). We identified one threshold only for muscle parameters with a non-linear decrease in muscle oxyhemoglobin (78 ± 9% of exercise), attenuation in muscle deoxyhemoglobin (80 ± 8% of exercise), and increase in EMG activity of VL (89 ± 5% of exercise), RF (82 ± 14% of exercise), and BF (85 ± 9% of exercise). The thresholds in BF and VL EMG activity occurred after the second ventilatory threshold (p < 0.05, d > 0.6). Our results suggest that the metabolic and ventilatory events characterizing this latter cardiopulmonary threshold may affect both cerebral and muscle oxygenation levels, and in turn, muscle recruitment responses. PMID:24782786

  18. Activity and recovery cycles of National Rugby League matches involving higher and lower ranked teams.

    PubMed

    Gabbett, Tim J

    2013-06-01

    This study investigated the influence of ladder position on ball-in-play and recovery periods in elite National Rugby League (NRL) competitive matches. Video recordings of 192 NRL matches and 18 NRL finals matches played over 2 competitive seasons were coded for activity and recovery cycles. Time when the ball was continuously in play was considered activity, whereas any stoppages during the match (e.g., for scrums, penalties, line drop outs, tries, and video referee decisions) were considered recovery. In comparison to matches involving lower standard teams, there was a greater proportion (effect size [ES] = 0.37-0.67) of long duration (>91 seconds) and a smaller proportion (ES = 0.49-0.68) of short duration (<45 seconds) ball-in-play periods when Top 4 teams were competing against other Top 4 teams. No meaningful differences were found between teams of different ladder positions for the proportion of short (ES = 0.04-0.16) and long (ES = 0.06-0.28) recovery periods. In comparison to fixture matches involving the top 4 teams, finals matches had a smaller proportion (ES = 0.56) of long duration activity periods, and a greater proportion (ES = 0.54) of short duration activity periods. Only small differences were found between finals matches and matches involving the Top 4 teams for the proportion of short (ES = 0.42) and long (ES = 0.41) recovery periods. These findings suggest that the competitive advantage of the best NRL teams is closely linked to their ability to maintain a higher playing intensity than less successful teams. Furthermore, long ball-in-play periods in high-standard fixture matches (i.e., involving the top 4 teams) ensure that players are adequately prepared for the ball-in-play demands of finals matches.

  19. Active Trans-Plasma Membrane Water Cycling in Yeast Is Revealed by NMR

    PubMed Central

    Zhang, Yajie; Poirier-Quinot, Marie; Springer, Charles S.; Balschi, James A.

    2011-01-01

    Plasma membrane water transport is a crucial cellular phenomenon. Net water movement in response to an osmotic gradient changes cell volume. Steady-state exchange of water molecules, with no net flux or volume change, occurs by passive diffusion through the phospholipid bilayer and passage through membrane proteins. The hypothesis is tested that plasma membrane water exchange also correlates with ATP-driven membrane transport activity in yeast (Saccharomyces cerevisiae). Longitudinal 1H2O NMR relaxation time constant (T1) values were measured in yeast suspensions containing extracellular relaxation reagent. Two-site-exchange analysis quantified the reversible exchange kinetics as the mean intracellular water lifetime (τi), where τi−1 is the pseudo-first-order rate constant for water efflux. To modulate cellular ATP, yeast suspensions were bubbled with 95%O2/5%CO2 (O2) or 95%N2/5%CO2 (N2). ATP was high during O2, and τi−1 was 3.1 s−1 at 25°C. After changing to N2, ATP decreased and τi−1 was 1.8 s−1. The principal active yeast ion transport protein is the plasma membrane H+-ATPase. Studies using the H+-ATPase inhibitor ebselen or a yeast genetic strain with reduced H+-ATPase found reduced τi−1, notwithstanding high ATP. Steady-state water exchange correlates with H+-ATPase activity. At volume steady state, water is cycling across the plasma membrane in response to metabolic transport activity. PMID:22261073

  20. Deformation across the seismic cycle in tectonically active regions: Imaging, modeling, and interpretations

    NASA Astrophysics Data System (ADS)

    Barnhart, William Douglas

    Images of surface displacements in response to tectonic forces can provide independent, spatially dense observations that assist in understanding sub-surface processes. When considered independently or augmented with more traditional observations of active tectonics such as seismicity and ground mapping, these measurements provide constraints on spatially and temporally variable fault behavior across the seismic cycle. Models of fault behavior inferred from these observations in turn allow us to address topics in geologic hazards assessment, the long- and short-term character of strain in deforming regions, and the interactions between faults throughout the crust. In this dissertation, I use remotely sensed observations of ground displacements from interferometric synthetic aperture radar (InSAR) to approach several problems related to earthquake and aseismic fault slip. I establish image processing and inverse methods for better detailing subsurface fault slip and apply these to the 2010-2011 Canterbury, New Zealand sequence. Then, I focus on the active tectonics of the Zagros Mountains in southern Iran. There, I show through orogen-wide InSAR time series analysis that active strain is accommodated across the width of the mountain belt. I also use a combination of InSAR, local seismicity, and structural modeling to demonstrate that strain is vertically partitioned within the Zagros fold-and-thrust belt, with earthquakes controlling deformation in the underlying basement while the overlying sedimentary section shortens in transient, earthquake-triggered aseismic slip events. In certain examples, these aseismic slip events directly contribute to the growth of fault-bend folds. I use these inferences to explore a previously noted discrepancy between observed shortening and that which is expected from known earthquakes. I show that the earthquakes and short-term aseismic slip cannot account for this discrepancy, and that additional deformation mechanisms must be

  1. Control Activity in Support of NASA Turbine Based Combined Cycle (TBCC) Research

    NASA Technical Reports Server (NTRS)

    Stueber, Thomas J.; Vrnak, Daniel R.; Le, Dzu K.; Ouzts, Peter J.

    2010-01-01

    Control research for a Turbine Based Combined Cycle (TBCC) propulsion system is the current focus of the Hypersonic Guidance, Navigation, and Control (GN&C) discipline team. The ongoing work at the NASA Glenn Research Center (GRC) supports the Hypersonic GN&C effort in developing tools to aid the design of control algorithms to manage a TBCC airbreathing propulsion system during a critical operating period. The critical operating period being addressed in this paper is the span when the propulsion system transitions from one cycle to another, referred to as mode transition. One such tool, that is a basic need for control system design activities, is computational models (hereto forth referred to as models) of the propulsion system. The models of interest for designing and testing controllers are Control Development Models (CDMs) and Control Validation Models (CVMs). CDMs and CVMs are needed for each of the following propulsion system elements: inlet, turbine engine, ram/scram dual-mode combustor, and nozzle. This paper presents an overall architecture for a TBCC propulsion system model that includes all of the propulsion system elements. Efforts are under way, focusing on one of the propulsion system elements, to develop CDMs and CVMs for a TBCC propulsion system inlet. The TBCC inlet aerodynamic design being modeled is that of the Combined-Cycle Engine (CCE) Testbed. The CCE Testbed is a large-scale model of an aerodynamic design that was verified in a small-scale screening experiment. The modeling approach includes employing existing state-of-the-art simulation codes, developing new dynamic simulations, and performing system identification experiments on the hardware in the NASA GRC 10 by10-Foot Supersonic Wind Tunnel. The developed CDMs and CVMs will be available for control studies prior to hardware buildup. The system identification experiments on the CCE Testbed will characterize the necessary dynamics to be represented in CDMs for control design. These

  2. Active and long-lived permanent forearc deformation driven by the subduction seismic cycle

    NASA Astrophysics Data System (ADS)

    Aron Melo, Felipe Alejandro

    I have used geological, geophysical and engineering methods to explore mechanisms of upper plate, brittle deformation at active forearc regions. My dissertation particularly addresses the permanent deformation style experienced by the forearc following great subduction ruptures, such as the 2010 M w8.8 Maule, Chile and 2011 Mw9.0 Tohoku, Japan earthquakes. These events triggered large, shallow seismicity on upper plate normal faults above the rupture reaching Mw7.0. First I present new structural data from the Chilean Coastal Cordillera over the rupture zone of the Maule earthquake. The study area contains the Pichilemu normal fault, which produced the large crustal aftershocks of the megathrust event. Normal faults are the major neotectonic structural elements but reverse faults also exist. Crustal seismicity and GPS surface displacements show that the forearc experiences pulses of rapid coseismic extension, parallel to the heave of the megathrust, and slow interseismic, convergence-parallel shortening. These cycles, over geologic time, build the forearc structural grain, reactivating structures properly-oriented respect to the deformation field of each stage of the interplate cycle. Great subduction events may play a fundamental role in constructing the crustal architecture of extensional forearc regions. Static mechanical models of coseismic and interseismic upper plate deformation are used to explore for distinct features that could result from brittle fracturing over the two stages of the interplate cycle. I show that the semi-elliptical outline of the first-order normal faults along the Coastal Cordillera may define the location of a characteristic, long-lived megathrust segment. Finally, using data from the Global CMT catalog I analyzed the seismic behavior through time of forearc regions that have experienced great subduction ruptures >Mw7.7 worldwide. Between 61% and 83% of the cases where upper plate earthquakes exhibited periods of increased seismicity

  3. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle.

    PubMed

    Trivedi, Darshan V; Muretta, Joseph M; Swenson, Anja M; Thomas, David D; Yengo, Christopher M

    2013-07-01

    We investigated how magnesium (Mg) impacts key conformational changes during the ADP binding/release steps in myosin V and how these alterations impact the actomyosin mechanochemical cycle. The conformation of the nucleotide binding pocket was examined with our established FRET system in which myosin V labeled with FlAsH in the upper 50 kDa domain participates in energy transfer with mant labeled nucleotides. We examined the maximum actin-activated ATPase activity of MV FlAsH at a range of free Mg concentrations (0.1-9 mM) and found that the highest activity occurs at low Mg (0.1-0.3 mM), while there is a 50-60% reduction in activity at high Mg (3-9 mM). The motor activity examined with the in vitro motility assay followed a similar Mg-dependence, and the trend was similar with dimeric myosin V. Transient kinetic FRET studies of mantdADP binding/release from actomyosin V FlAsH demonstrate that the transition between the weak and strong actomyosin.ADP states is coupled to movement of the upper 50 kDa domain and is dependent on Mg with the strong state stabilized by Mg. We find that the kinetics of the upper 50 kDa conformational change monitored by FRET correlates well with the ATPase and motility results over a wide range of Mg concentrations. Our results suggest the conformation of the upper 50 kDa domain is highly dynamic in the Mg free actomyosin.ADP state, which is in agreement with ADP binding being entropy driven in the absence of Mg. Overall, our results demonstrate that Mg is a key factor in coupling the nucleotide- and actin-binding regions. In addition, Mg concentrations in the physiological range can alter the structural transition that limits ADP dissociation from actomyosin V, which explains the impact of Mg on actin-activated ATPase activity and in vitro motility.

  4. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

    PubMed

    Roberts, Bracken F; Iyamu, Iredia D; Lee, Sukjun; Lee, Eunyoung; Ayong, Lawrence; Kyle, Dennis E; Yuan, Yu; Manetsch, Roman; Chakrabarti, Debopam

    2016-04-01

    We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials. PMID:27054067

  5. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

    PubMed Central

    Roberts, Bracken F.; Iyamu, Iredia D.; Lee, Sukjun; Lee, Eunyoung; Ayong, Lawrence; Kyle, Dennis E.; Yuan, Yu; Manetsch, Roman; Chakrabarti, Debopam

    2016-01-01

    We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials. PMID:27054067

  6. The Dst index underestimates the solar cycle variation of geomagnetic activity

    NASA Astrophysics Data System (ADS)

    Temerin, Michael; Li, Xinlin

    2015-07-01

    It is known that the correction of the Kyoto Dst index for the secular variation of the Earth's internal field produces a discontinuity in the Kyoto Dst index at the end of each year. We show that this secular correction also introduces a significant baseline error to the Kyoto Dst index that leads to an underestimate of the solar cycle variation of geomagnetic activity and of the strength of the ring current as measured by the Kyoto Dst index. Thus, the average value of the Kyoto Dst index would be approximately 13 nT more negative for the active year 2003 compared to quiet years 2006 and 2009 if the Kyoto Dst index properly measured the effects of the ring current and other currents that influence the Dst observatories. Discontinuities in the Kyoto Dst index at the end of each year have an average value of about 5 nT, but the discontinuity at the end of year 2002 was approximately 12 nT, and the discontinuity at the end of year 1982 may have been as large as 20 nT.

  7. Antibacterial Activity, in Vitro Cytotoxicity, and Cell Cycle Arrest of Gemini Quaternary Ammonium Surfactants.

    PubMed

    Zhang, Shanshan; Ding, Shiping; Yu, Jing; Chen, Xuerui; Lei, Qunfang; Fang, Wenjun

    2015-11-10

    Twelve gemini quaternary ammonium surfactants have been employed to evaluate the antibacterial activity and in vitro cytotoxicity. The antibacterial effects of the gemini surfactants are performed on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with minimum inhibitory concentrations (MIC) ranging from 2.8 to 167.7 μM. Scanning electron microscopy (SEM) analysis results show that these surfactants interact with the bacterial cell membrane, disrupt the integrity of the membrane, and consequently kill the bacteria. The data recorded on C6 glioma and HEK293 human kidney cell lines using an MTT assay exhibit low half inhibitory concentrations (IC50). The influences of the gemini surfactants on the cell morphology, the cell migration ability, and the cell cycle are observed through hematoxylin-eosin (HE) staining, cell wound healing assay, and flow cytometric analyses, respectively. Both the values of MIC and IC50 decrease against the growth of the alkyl chain length of the gemini surfactants with the same spacer group. In the case of surfactants 12-s-12, the MICs and IC50s are found to decrease slightly with the spacer chain length changing from 2 to 8 and again to increase at higher spacer length (s = 10-12). All of the gemini surfactants show great antibacterial activity and cytotoxicity, and they might exhibit potential applications in medical fields.

  8. Continued Development of the Rapid Cycle Amine (RCA) System for Advanced Extravehicular Activity Systems

    NASA Technical Reports Server (NTRS)

    Papale, William; Chullen, Cinda; Campbell, Colin; Conger, Bruce; McMillin, Summer; Jeng, Frank

    2014-01-01

    Development activities related to the Rapid Cycle Amine (RCA) Carbon Dioxide (CO2) and Humidity control system have progressed to the point of integrating the RCA into an advanced Primary Life Support System (PLSS 2.0) to evaluate the interaction of the RCA among other PLSS components in a ground test environment. The RCA 2.0 assembly (integrated into PLSS 2.0) consists of a valve assembly with commercial actuator motor, a sorbent canister, and a field-programmable gate array (FPGA)-based process node controller. Continued design and development activities for RCA 3.0 have been aimed at optimizing the canister size and incorporating greater fidelity in the valve actuator motor and valve position feedback design. Further, the RCA process node controller is envisioned to incorporate a higher degree of functionality to support a distributed PLSS control architecture. This paper will describe the progression of technology readiness levels of RCA 1.0, 2.0 and 3.0 along with a review of the design and manufacturing successes and challenges for 2.0 and 3.0 units. The anticipated interfaces and interactions with the PLSS 2.0/2.5/3.0 assemblies will also be discussed.

  9. The dietary intake of a group of vegetarian children aged 7-11 years compared with matched omnivores.

    PubMed

    Nathan, I; Hackett, A F; Kirby, S

    1996-04-01

    There is a lack of information concerning the diet of vegetarian children. The present study compared the dietary intake of fifty vegetarian children, aged 7-11 years, with fifty matched omnivores. Three 3 d food records were completed by each child at intervals of 6 months. The day after completing the record each child was interviewed to clarify food items and assess portion sizes. Food records were analysed using Microdiet (University of Salford). Finger-prick cholesterol and haemoglobin measurements were taken from a subsample of the group. Only one child's family was a member of the Vegetarian Society and almost one-third of vegetarian children had omnivorous parents (seventeen of fifty subjects). The energy intake (MJ) of the vegetarians was significantly lower than that of the omnivores, 7.6 (SD 1.05) and 8.0 (SD 1.36) respectively; there were no significant differences in Fe or fat intakes. For the vegetarians polyunsaturated:saturated fat ratio (P:S 0.7 (SD 0.04)) and NSP intake (13.8 (SD 0.7) g/d) were significantly higher than those of the omnivores (P:S 0.5 (SD 0.02), NSP 10.3 (SD 0.4) g/d). There was no significant difference in cholesterol measurements (mmol/l) between the two groups: vegetarian 3.5 (SD 0.12), omnivores 3.7 (SD 0.15). The haemoglobin level (g/l) of the vegetarians (11.8 (SD 0.2)) was significantly below that of the omnivores (12.4 (SD 0.2)); 47.5% of the vegetarian children fell below the third percentile of the Dallman reference curves (Dallman & Siimes, 1979). The intake of the vegetarians more closely resembled current recommendations (Department of Health, 1991), although they need to be as aware as omnivores of the need to reduce fat intake. The haemoglobin levels of vegetarian children suggest that they need dietary advice to ensure optimal absorption of Fe.

  10. The effects of 8-week speed training program on the acceleration ability and maximum speed running at 11 years athletes.

    PubMed

    Gevat, Cecilia; Taskin, Halil; Arslan, Fatma; Larion, Alin; Stanculescu, George

    2012-09-01

    The aim of this study was to examine the effects of an 8-week speed training program on the acceleration ability and maximum speed at 11 years athletes. A total of 30 healthy female athletes volunteered to participate in this study. They were divided randomly into 1 of 2 groups: Experimental group (EG; N = 15) and control group (CG; N = 15). The mean (SD) age was 11.20 +/- 0.32 years, height was 1.44 +/- 0.08 m, and weight was 35.20 +/- 2.02 kg for the experimental group; the mean (SD) age was 11.40 +/- 0.39 years, height was 1.45 +/- 0.05 m, and weight was 36.06 +/- 1.15 kg for the control group. A speed training program was applied to the subjects 3 days a week for 8 weeks. Testing was conducted before and after 8 weeks of training. Acceleration and maximum speed was evaluated for 15-m and 30-m, respectively, involving sprinting 15 m and 30 m as fast as possible from a stationary start position that was ascertained during a 50-m. Electronic timekeeping was conducted by the facility--Brower Timing System--made in Utah, USA., consisting of 4 components. Paired t-tests detected significant differences in pre- and posttests for clearance time of 5 m during 50 m in the experimental and control groups (p < 0.05). Therefore, acceleration phase was significantly reduce at 15 m distance interval for the experimental group and control groups posttraining than pretraining (0-15 m, p < 0.05). Acceleration improvement was 12.6% for the experimental group posttraining, on the other hand, acceleration improvement was 5% for the control groups posttraining. we did not find significant difference between pretest and posttest in 10-15 m, 15-20 m, and 20-25 m for the experimental group (p > 0.05). On the other hand, we did find significant difference between pretest and posttest values of other clearance times of consecutively each 5m during 50 m for the experimental and control groups (p < 0.05). Also, this study observed that athletes reached maximum speed in 30 m. In conclusion

  11. THREE-DIMENSIONAL FEATURES OF THE OUTER HELIOSPHERE DUE TO COUPLING BETWEEN THE INTERSTELLAR AND INTERPLANETARY MAGNETIC FIELDS. III. THE EFFECTS OF SOLAR ROTATION AND ACTIVITY CYCLE

    SciTech Connect

    Pogorelov, Nikolai V.; Borovikov, Sergey N.; Zank, Gary P.; Ogino, Tatsuki E-mail: snb0003@uah.edu E-mail: ogino@stelab.nagoya-u.ac.jp

    2009-05-10

    We investigate the effects of the 11 year solar cycle and 25 day rotation period of the Sun on the interaction of the solar wind (SW) with the local interstellar medium (LISM). Our models take into account the partially ionized character of the LISM and include momentum and energy transfer between the ionized and neutral components. We assume that the interstellar magnetic field vector belongs to the hydrogen deflection plane as discovered in the SOHO SWAN experiment. This plane is inclined at an angle of about 60 deg. toward the ecliptic plane of the Sun, as suggested in recent publications relating the local interstellar cloud properties to the radio emission observed by Voyager 1. It is assumed that the latitudinal extent of the boundary between the slow and fast SW regions, as well as the angle between the Sun's rotation and magnetic-dipole axes, are periodic functions of time, while the polarity of the interstellar magnetic field changes sign every 11 years at the solar maximum. The global variation of the SW-LISM interaction pattern, the excursions of the termination shock and the heliopause, and parameter distributions in certain directions are investigated. The analysis of the behavior of the wavy heliospheric current sheet in the supersonic SW region shows the importance of neutral atoms on its dynamics.

  12. Deleterious effect of suboptimal diet on rest-activity cycle in Anastrepha ludens manifests itself with age

    PubMed Central

    Chiu, Joanna C.; Kaub, Kevin; Zou, Sige; Liedo, Pablo; Altamirano-Robles, Leopoldo; Ingram, Donald; Carey, James R.

    2013-01-01

    Activity patterns and sleep-wake cycles are among the physiological processes that change most prominently as animals age, and are often good indicators of healthspan. In this study, we used the video-based high-resolution Behavioral Monitoring System (BMS) to monitor the daily activity cycle of tephritid fruit flies Anastrepha ludens over their lifetime. Surprisingly, there was no dramatic change in activity profile with respect to age if flies were consistently fed with a nutritionally balanced diet. However, if flies were fed with sugar-only diet, their activity profile decreased in amplitude at old age, suggesting that suboptimal diet affected activity patterns, and its detrimental effect may not manifest itself until the animal ages. Moreover, by simulating different modes of behavior monitoring with a range of resolution and comparing the resulting conclusions, we confirmed the superior performance of video-based monitoring using high-resolution BMS in accurately representing activity patterns in an insect model. PMID:23639915

  13. Evaluation of the effects of ozone oxidation on redox-cycling activity of two-stroke engine exhaust particles.

    PubMed

    McWhinney, Robert D; Gao, Shawna S; Zhou, Shouming; Abbatt, Jonathan P D

    2011-03-15

    The effect of oxidation on the redox-cycling activity of engine exhaust particles is examined. Particles obtained from a two-stroke gasoline engine were oxidized in a flow tube with ozone on a one-minute time scale both in the presence and absence of substantial gas-phase exhaust components. Whereas ozone concentrations were high, the ozone exposures were approximately equivalent to 60 ppb ozone for 2-8 h. Oxidation led to substantial increases in redox-cycling of aqueous extracts of filtered particles, as measured using the dithiothreitol (DTT) assay. Increases in redox activity when the entire exhaust was oxidized were primarily driven by deposition of redox-active secondary organic aerosol (SOA), resulting in an upper-limit DTT activity of 8.6 ± 2.0 pmol DTT consumed per min per microgram of particles, compared to 0.73 ± 0.60 pmol min(-1) μg(-1) for fresh, unoxidized exhaust particles. Redox-cycling activity reached higher levels when VOC denuded exhaust was oxidized, with the highest DTT activity observed being 16.7 ± 1.6 pmol min(-1) μg(-1) with no upper limit reached for the range of ozone exposures used in this study. Our results provide laboratory support for the hypothesis that the toxicity of engine combustion particles due to redox-cycling may increase as they age in the atmosphere.

  14. Changes in the activities of key enzymes of glycolysis during the cell cycle in yeast: a rectification.

    PubMed

    de Koning, W; Groeneveld, K; Oehlen, L J; Berden, J A; van Dam, K

    1991-04-01

    Activities of glycolytic enzymes were determined in elutriation fractionated cultures of Saccharomyces cerevisiae grown on different carbon sources. Almost pure fractions of single cells at the G1 state of cell division were obtained for some of the growth conditions tested, whereas other stages were enriched in particular fractions. Specific activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase were found to be constant during the cell cycle, as reported by van Doorn et al. (1988a), Journal of Bacteriology 170, 4808-4815, and (1988b), Journal of General Microbiology 134, 785-790. In contrast to the earlier reports, the activities of hexokinase, phosphofructokinase, pyruvate kinase and trehalase were also constant in different states of the cell cycle. For hexokinase and phosphofructokinase it was shown that the apparent specific activity in a cell-free extract strongly diminished when extracts contained less that 0.5-1 mg protein ml-1. In the experiments of van Doorn et al. (1988a) the protein content of the outer fractions was up to 20 times lower than that of the central fractions, suggesting an alternative explanation for the observed changes in enzyme activities during the cell cycle. Therefore, we want to rectify the observations presented by van Doorn et al. (1988a), and conclude that the activities of the glycolytic enzymes do not vary greatly during the cell cycle of S. cervisiae. PMID:1856683

  15. Thermal activation of CaO-based sorbent and self-reactivation during CO{sub 2} capture looping cycles

    SciTech Connect

    Vasilije Manovic; Edward J. Anthony

    2008-06-01

    In this study, the thermal activation of different types of CaO-based sorbents was examined. Pretreatments were performed at different temperatures (800-1300{sup o}C) and different durations (6-48 h) using four Canadian limestones. Sieved fractions of the limestones, powders obtained by grinding, and hydroxides produced following multiple carbonation/calcination cycles achieved in a tube furnace were examined. Pretreated samples were evaluated using two types of thermogravimetric reactors/analyzers. The most important result was that thermal pretreatment could improve sorbent performance. In comparison to the original, pretreated sorbents showed better conversions over a longer series of CO{sub 2} cycles. Moreover, in some cases, sorbent activity actually increased with cycle number, and this effect was especially pronounced for powdered samples preheated at 1000{sup o}C. In these experiments, the increase of conversion with cycle number (designated as self-reactivation) after 30 cycles produced samples that were about 50% carbonated for the four sorbents examined here, and there appeared to be the potential for additional increase. These results were explained with the newly proposed pore-skeleton model. This model suggests, in addition to changes in the porous structure of the sorbent, that changes in the pore-skeleton produced during pretreatment strongly influence subsequent carbonation/calcination cycles. 31 refs., 8 figs.

  16. Thermal activation of CaO-based sorbent and self-reactivation during CO2 capture looping cycles.

    PubMed

    Manovic, Vasilije; Anthony, Edward J

    2008-06-01

    In this study, the thermal activation of different types of CaO-based sorbents was examined. Pretreatments were performed at different temperatures (800--1300 degrees C) and different durations (6--48 h) using four Canadian limestones. Sieved fractions of the limestones, powders obtained by grinding, and hydroxides produced following multiple carbonation/calcination cycles achieved in a tube furnace were examined. Pretreated samples were evaluated using two types of thermogravimetric reactors/ analyzers. The most important result was that thermal pretreatment could improve sorbent performance. In comparison to the original, pretreated sorbents showed better conversions over a longer series of CO2 cycles. Moreover, in some cases, sorbent activity actually increased with cycle number, and this effectwas especially pronounced for powdered samples preheated at 1000 degrees C. In these experiments, the increase of conversion with cycle number (designated as self-reactivation) after 30 cycles produced samples that were approximately 50% carbonated for the four sorbents examined here, and there appeared to be the potential for additional increase. These results were explained with the newly proposed pore--skeleton model. This model suggests, in addition to changes in the porous structure of the sorbent, that changes in the pore--skeleton produced during pretreatment strongly influence subsequent carbonation/ calcination cycles. PMID:18589983

  17. Disturbance of the phosphorus cycle: A case of indirect effects of human activity.

    PubMed

    Caraco, N F

    1993-02-01

    Phosphorus (P) often limits primary productivity of aquatic systems. Humans have altered the P cycle in aquatic systems, directly, by mining P-rich rock, and indirectly, through the manipulation of other element cycles and the alteration of aquatic food webs. Aquatic ecologists are becoming increasingly aware of the importance of these indirect alterations to biogeochemical cycles. Ouantitative predictions of these indirect effects will be an important focus of future studies.

  18. Bisphenol A, phthalates and lead and learning and behavioral problems in Canadian children 6-11 years of age: CHMS 2007-2009.

    PubMed

    Arbuckle, Tye E; Davis, Karelyn; Boylan, Khrista; Fisher, Mandy; Fu, Jingshan

    2016-05-01

    Childhood developmental disorders and related problems such as learning disabilities and attention deficit hyperactivity disorder (ADHD) account for a growing burden on the family, education and health care systems. Exposure to environmental chemicals such as bisphenol A (BPA) and phthalates may play a role in the development of child behavioral problems. Using cross-sectional data from Cycle 1 of the Canadian Health Measures Survey (CHMS), we examined the potential association between urinary concentrations of BPA and various phthalate metabolites and child learning and behavioral problems, considering important covariates such as gender, blood