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Sample records for 11-year activity cycle

  1. On the existence of the 11-year cycle in solar activity before the Maunder minimum

    SciTech Connect

    Attolini, M.R.; Cecchini, S.; Cini Castagnoli, G.; Galli, M.; Nanni, T.

    1988-11-01

    The existence of the 11-year cycle in solar activity before the Maunder minimum is clearly demonstrated with cosmogenic /sup 10/Be in polar ice during 1180--1500 A.D. For that interval a periodicity of 11.4 +- 0.2 years is found with a high significance level. Indication of a cyclicity that resembles the Hale magnetic cycle is also observed at a lower significance level. A highly variable cyclicity in the band 9.5--11.5 years is also found in the record of historical aurorae which appears to be well correlated with the /sup 10/Be cyclicity for the same time interval. It is concluded that the Schwabe, or 11-year, cycle and the Hale magnetic cycle were present before and after the Maunder minimum, even though it is not possible to understand the variability of the cycle. copyright American Geophysical Union 1988

  2. Fluctuations of the Caspian Sea level in the quasi-two-year and 11-year cycles of solar activity

    SciTech Connect

    Nuzhdina, M.A.

    1995-07-01

    Fluctuations of the Caspian Sea level due to dynamics of solar activity in its quasi-two-year and 11-year cycles, as well as to the influence of the 22-to 23-year magnetic cycle are analyzed. Perturbation of the geomagnetic field and the atmospheric circulation are regarded as a transmitting mechanism of the Sun`s influence on the Earth`s hydrosphere.

  3. Relationship between the north-south asymmetry of sunspot formation and the amplitude of 11-year solar activity cycles

    NASA Astrophysics Data System (ADS)

    Latyshev, S. V.; Olemskoy, S. V.

    2016-07-01

    A relationship between the north-south asymmetry of sunspot formation and the amplitude of 11-year cycles has been established from the RGO/USAF/NOAA data on sunspots. It is shown that the higher the solar cycle amplitude, the smaller the absolute value of the north-south asymmetry. The revealed pattern has been investigated in a numerical dynamo model with irregular variations of the alpha-effect.

  4. The 11-year cycle in human births

    NASA Astrophysics Data System (ADS)

    Randall, Walter; Moos, Walter S.

    1993-06-01

    The annual numbers of human births were analyzed with regard to an 11-year cycle. The annual values were obtained from seven different regions: Australia, Germany, England and Wales, New Zealand, Japan, Switzerland, and the USA. Fifty-five annual values were obtained from each region for the years 1930 to 1984, comprising approximately five sunspot cycles. For each region the annual values were formed into 5 by 11 matrices; the eleven column means obtained were standardized, and plotted. A periodic regression technique, utilizing the fitting functions of the Fourier series, was used to evaluate the temporal order in the column means. Eleven-year rhythms were found and compared with solar and geophysical variables. Correlations were found with sunspots and solar flares, with terrestrial measures of magnetic disturbances (the magnetic indices derived from the K-index), and with temperature. The correlation of conceptions with the 11-year solar cycle may be a potential guide in the selection of further variables for the control and regulation of the rhythms in human conceptions.

  5. 11 -year planetary index of solar activity

    NASA Astrophysics Data System (ADS)

    Okhlopkov, Victor

    In papers [1,2] introduced me parameter - the average difference between the heliocentric longitudes of planets ( ADL ) , which was used for comparison with solar activity. The best connection of solar activity ( Wolf numbers used ) was obtained for the three planets - Venus, Earth and Jupiter. In [1,2] has been allocated envelope curve of the minimum values ADL which has a main periodicity for 22 years and describes well the alternating series of solar activity , which also has a major periodicity of 22. It was shown that the minimum values of the envelope curve extremes ADL planets Venus, Earth and Jupiter are well matched with the 11- year solar activity cycle In these extremes observed linear configuration of the planets Venus, Earth and Jupiter both in their location on one side of the Sun ( conjunctions ) and at the location on the opposite side of the Sun ( three configurations ) This work is a continuation of the above-mentioned , and here for minimum ADL ( planets are in conjunction ) , as well as on the minimum deviation of the planets from a line drawn through them and Sun at the location of the planets on opposite sides of the Sun , compiled index (denoted for brevity as JEV ) that uniquely describes the 11- year solar cycle A comparison of the index JEV with solar activity during the time interval from 1000 to 2013 conducted. For the period from 1000 to 1699 used the Schove series of solar activity and the number of Wolf (1700 - 2013 ) During the time interval from 1000 to 2013 and the main periodicity of the solar activity and the index ADL is 11.07 years. 1. Okhlopkov V.P. Cycles of Solar Activity and the Configurations of Planets // Moscow University Physics Bulletin, 2012 , Vol. 67 , No. 4 , pp. 377-383 http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.3103/S0027134912040108. 2 Okhlopkov VP, Relationship of Solar Activity Cycles to Planetary Configurations // Bulletin of the Russian Academy of Sciences. Physics, 2013 , Vol. 77 , No. 5

  6. Difference between even and odd cycles in the predictability of the amplitude of the around 11-year-period solar activity and prediction of the amplitude of cycle 25

    NASA Astrophysics Data System (ADS)

    Yoshida, A.; Sayre, R. J.

    2012-12-01

    The waxing and waning of the solar activity represented by a period of roughly 11 years is usually quantified by the change in the sunspot number (SSN). It is commonly held that these increases and decreases in the SSN as well as the changes in the general dipole-like magnetic field in the photosphere and corona are produced by a magneto-hydro dynamic process in the sun's underlying convection layer. Assuming this is the case, it follows that SSNs in past cycles should contain a certain kind of information that enables us to estimate the amplitudes of future cycles. We report here a set of new results along this line of research. The chief aim of this paper is to demonstrate a distinct difference in the predictability of solar activity between even and odd cycles. Yoshida and Yamagishi (2010) showed that the SSN at the point three years before a minimum is well correlated with the maximum SSN in the following cycle. Here, we show that the correlation between this locus and the average SSN supplies a higher correlation coefficient. Moreover, we demonstrate that the correlation coefficient for even cycles is far better than that for odd ones (i.e., 0.96 and 0.74, respectively). Though it has been known that the correlation between the SSN at a point three years after a minimum and the maximum SSN is high, we demonstrate here that taking this calculation along with the average SSN (instead of the maximum SSN), the correlation coefficient for even cycles (0.98) reveals itself to be noticeably larger than that for odd cycles (0.93). Furthermore, we have found that the average SSN of even cycles is highly correlated with that of succeeding odd cycles (i.e., the correlation coefficient - minus three outliers - is 0.99). Conversely, no correlation is observed between amplitudes of odd cycles and those of succeeding even cycles. These distinct differences between even-odd pairs and odd-even pairs in their connective features lead us to believe that pairs of even-odd cycles

  7. Analysis of the sensitivity of the composition and temperature of the stratosphere to the variability of spectral solar radiation fluxes induced by the 11-year cycle of solar activity

    NASA Astrophysics Data System (ADS)

    Smyshlyaev, S. P.; Galin, V. Ya.; Blakitnaya, P. A.; Lemishchenko, A. K.

    2016-01-01

    The sensitivity of the gas composition of the atmosphere and its temperature to the changes in spectral radiation fluxes during the 11-year cycle of solar activity has been analyzed with a chemistry-climate model of the lower and middle atmosphere. For this, the data of satellite measurements acquired in the first decade of the 21st century were used. The results of the model calculations showed that, in addition to the increase in the spectral flux in the absorption bands of molecular oxygen that leads to the growth of the ozone content, the changes in the flux at longer wavelengths are significant for the composition and temperature of the atmosphere. The changes of the ozone destruction rate in different catalytic cycles partly compensate each other; in these processes, the destruction rate increases in the reaction with atomic oxygen, while it decreases in the hydrogen and chlorine cycles.

  8. The 11 years solar cycle as the manifestation of the dark Universe

    SciTech Connect

    Zioutas, K.; Semertzidis, Y.; Tsagri, M.; Papaevangelou, T.; Hoffmann, D. H.H.; Anastassopoulos, V.

    2014-11-26

    Sun’s luminosity in the visible changes at the 10-3 level, following an 11 years period. In X-rays, which should not be there, the amplitude varies even ~105 times stronger, making their mysterious origin since the discovery in 1938 even more puzzling, and inspiring. We suggest that the multifaceted mysterious solar cycle is due to some kind of dark matter streams hitting the Sun. Planetary gravitational lensing enhances (occasionally) slow moving flows of dark constituents towards the Sun, giving rise to the periodic behaviour. Jupiter provides the driving oscillatory force, though its 11.8 years orbital period appears slightly decreased, just as 11 years, if the lensing impact of other planets is included. Then, the 11 years solar clock may help to decipher (overlooked) signatures from the dark sector in laboratory experiments or observations in space.

  9. The 11 years solar cycle as the manifestation of the dark Universe

    DOE PAGESBeta

    Zioutas, K.; Semertzidis, Y.; Tsagri, M.; Papaevangelou, T.; Hoffmann, D. H.H.; Anastassopoulos, V.

    2014-11-26

    Sun’s luminosity in the visible changes at the 10-3 level, following an 11 years period. In X-rays, which should not be there, the amplitude varies even ~105 times stronger, making their mysterious origin since the discovery in 1938 even more puzzling, and inspiring. We suggest that the multifaceted mysterious solar cycle is due to some kind of dark matter streams hitting the Sun. Planetary gravitational lensing enhances (occasionally) slow moving flows of dark constituents towards the Sun, giving rise to the periodic behaviour. Jupiter provides the driving oscillatory force, though its 11.8 years orbital period appears slightly decreased, just asmore » 11 years, if the lensing impact of other planets is included. Then, the 11 years solar clock may help to decipher (overlooked) signatures from the dark sector in laboratory experiments or observations in space.« less

  10. Amplifying the Pacific climate system response to a small 11-year solar cycle forcing.

    PubMed

    Meehl, Gerald A; Arblaster, Julie M; Matthes, Katja; Sassi, Fabrizio; van Loon, Harry

    2009-08-28

    One of the mysteries regarding Earth's climate system response to variations in solar output is how the relatively small fluctuations of the 11-year solar cycle can produce the magnitude of the observed climate signals in the tropical Pacific associated with such solar variability. Two mechanisms, the top-down stratospheric response of ozone to fluctuations of shortwave solar forcing and the bottom-up coupled ocean-atmosphere surface response, are included in versions of three global climate models, with either mechanism acting alone or both acting together. We show that the two mechanisms act together to enhance the climatological off-equatorial tropical precipitation maxima in the Pacific, lower the eastern equatorial Pacific sea surface temperatures during peaks in the 11-year solar cycle, and reduce low-latitude clouds to amplify the solar forcing at the surface. PMID:19713524

  11. Evidence for climate variations induced by the 11-year solar and cosmic rays cycles

    NASA Astrophysics Data System (ADS)

    Bruckman, William; Ramos, Elio

    2010-02-01

    We analyzed data from PSMSL monthly mean sea level seeking correlations between sea level fluctuations and the solar and cosmic rays 11 year cycle. The data reveals decadal variability that could be causally connected to the solar and cosmic rays cycle, since these periodic changes are correlated. It is also found that the solar (cosmic rays) cycle correlates (anti-correlates) with the mean global surface temperature anomaly. A probable explanation of the above correlations is that the solar intensity and cosmic rays variations induce oscillations in the average temperature and precipitation, with corresponding changes in the continental water and snow accumulation. Thus, for instance, a higher than average snow and water over land, and lower temperatures produce oceans thermal contraction and lower mass, implicating lower mean sea level.

  12. Modulation of the Arctic Oscillation and the East Asian winter climate relationships by the 11-year solar cycle

    NASA Astrophysics Data System (ADS)

    Chen, Wen; Zhou, Qun

    2012-03-01

    The modulation of the relationship between the Arctic Oscillation (AO) and the East Asian winter climate by the 11-year solar cycle was investigated. During winters with high solar activity (HS), robust warming appeared in northern Asia in a positive AO phase. This result corresponded to an enhanced anticyclonic flow at 850 hPa over northeastern Asia and a weakened East Asian trough (EAT) at 500 hPa. However, during winters with low solar activity (LS), both the surface warming and the intensities of the anticyclonic flow and the EAT were much less in the presence of a positive AO phase. The possible atmospheric processes for this 11-year solar-cycle modulation may be attributed to the indirect influence that solar activity induces in the structural changes of AO. During HS winters, the sea level pressure oscillation associated with the AO became stronger, with the significant influence of AO extending to East Asia. In the meantime, the AO-related zonal-mean zonal winds tended to extend more into the stratosphere during HS winters, which implies a stronger coupling to the stratosphere. These trends may have led to an enhanced AO phase difference; thus the associated East Asian climate anomalies became larger and more significant. The situation tended to reverse during LS winters. Further analyses revealed that the relationship between the winter AO and surface-climate anomalies in the following spring is also modulated by the 11-year solar cycle, with significant signals appearing only during HS phases. Solar-cycle variation should be taken into consideration when the AO is used to predict winter and spring climate anomalies over East Asia.

  13. On the ambiguous nature of the 11-year solar cycle signal profile in stratospheric ozone

    NASA Astrophysics Data System (ADS)

    Dhomse, Sandip; Chipperfield, Martyn; Damadeo, Robert; Zawodny, Joe; Ball, William; Feng, Wuhu; Hossaini, Ryan; Mann, Graham; Haigh, Joana

    2016-04-01

    We use three satellite datasets and simulations from a 3-D chemical transport model, forced by three different solar flux datasets, to diagnose the 11-year solar cycle signal (SCS) in stratospheric ozone. Our analysis shows that compared to SAGE II v6.2, a reduced upper stratospheric SCS in SAGE II v7.0 is due to a more realistic ozone-temperature anti-correlation. Overall, all model simulations show a positive SCS in the lower and middle stratosphere and negligible SCS in the upper stratosphere in agreement with SAGE v7.0, HALOE and MLS data. The model simulations show a differently structured SCS over different time periods covered by the satellite datasets, which helps to resolve some observed differences. However, despite the improvements to the SAGE II data, due to remaining biases in current observational and reanalysis datasets, accurate quantification of the influence of solar flux variability on the climate system remains an open scientific question.

  14. The response of chemistry and climate to the 11-year solar cycle in UM-UKCA

    NASA Astrophysics Data System (ADS)

    Bednarz, Ewa; Telford, Paul; Maycock, Amanda; Abraham, Luke; Braesicke, Peter; Pyle, John

    2014-05-01

    It is now generally agreed that the UV variability associated with the 11-year solar cycle leads to changes in ozone and temperature in the upper stratosphere. In addition, a range of observational and modelling studies suggest that such changes are the starting point for a chain of processes (including feedbacks) resulting in circulation changes in many areas of the atmosphere. However, precise details of the interactions between chemistry and meteorology induced by solar variability remain under question. In our study, we use a version of the UM-UKCA chemistry-climate model with consistent spectrally-resolved solar variability. While the solar cycle in heating rates has been applied with the method used in HadGEM2-ES, fine spectrally-resolved solar variability has been uniquely incorporated into the Fast-JX photolysis scheme. We perform two 50-year-long perpetual year solar maximum and solar minimum integrations and complement them with a three member ensemble of a transient 1960-2010 integration in which boundary conditions correspond by and large to the CCMI Ref-C1 scenario. We show how the inferred solar signals vary between the individual experiments. This indicates high natural variability and the resulting contamination of the solar signal with contributions from other processes as well as the existence of possible non-linearities between the solar cycle and other atmospheric forcings. Therefore, we highlight that long data series are needed to ensure correct attribution of the modelled and observed anomalies. In addition, we present results from two perpetual year experiments in which the solar cycle was applied exclusively in either short-wave heating or photolysis. We find large non-linearities in the modelled anomalies as compared to the realistic integration with both modulations included. This highlights the subtle nature of the dynamical response to the solar cycle forcing and indicates the need for interactive chemistry with a detailed photolysis

  15. Using the 11-year Solar Cycle to Predict the Heliosheath Environment at Voyager 1 and 2

    NASA Astrophysics Data System (ADS)

    Michael, A.; Opher, M.; Provornikova, E.; Richardson, J. D.; Toth, G.

    2015-12-01

    As Voyager 2 moves further into the heliosheath, the region of subsonic solar wind plasma in between the termination shock and the heliopause, it has observed an increase of the magnetic field strength to large values, all while maintaining magnetic flux conservation. Dr. Burlaga will present these observations in the 2015 AGU Fall meeting (abstract ID: 59200). The increase in magnetic field strength could be a signature of Voyager 2 approaching the heliopause or, possibly, due to solar cycle effects. In this work we investigate the role the 11-year solar cycle variations as well as magnetic dissipation effects have on the heliosheath environments observed at Voyager 1 and 2 using a global 3D magnetohydrodynamic model of the heliosphere. We use time and latitude-dependent solar wind velocity and density inferred from SOHO/SWAN and IPS data and solar cycle variations of the magnetic field derived from 27-day averages of the field magnitude average of the magnetic field at 1 AU from the OMNI database as presented in Michael et al. (2015). Since the model has already accurately matched the flows and magnetic field strength at Voyager 2 until 93 AU, we extend the boundary conditions to model the heliosheath up until Voyager 2 reaches the heliopause. This work will help clarify if the magnetic field observed at Voyager 2 should increase or decrease due to the solar cycle. We describe the solar magnetic field both as a dipole, with the magnetic and rotational axes aligned, and as a monopole, with magnetic field aligned with the interstellar medium to reduce numerical reconnection within the heliosheath, due to the removal of the heliospheric surrent sheet, and at the solar wind - interstellar medium interface. A comparison of the models allows for a crude estimation of the role that magnetic dissipation plays in the system and whether it allows for a better understanding of the Voyager 2 location in the heliosheath.

  16. The 11 year solar cycle signature on wave-driven dynamics in WACCM

    NASA Astrophysics Data System (ADS)

    Cullens, Chihoko Y.; England, Scott L.; Garcia, Rolando R.

    2016-04-01

    This study describes the influence of the 11 year solar cycle on gravity waves and the wave-driven circulation, using an ensemble of six simulations of the period from 1955 to 2005 along with fixed solar maximum and minimum simulations of the Whole Atmospheric Community Climate Model (WACCM). Solar cycle signals are estimated by calculating the difference between solar maximum and minimum conditions. Simulations under both time-varying and fixed solar inputs show statistically significant responses in temperatures and winds in the Southern Hemisphere (SH) during austral winter and spring. At solar maximum, the monthly mean, zonal mean temperature in the SH from July to October is cooler (~1-3 K) in the stratosphere and warmer (~1-4 K) in the mesosphere and the lower thermosphere (MLT). In solar maximum years, the SH polar vortex is more stable and its eastward speed is about 5-8 m s-1 greater than during solar minimum. The increase in the eastward wind propagates downward and poleward from July to October in the SH. Because of increase in the eastward wind, the propagation of eastward gravity waves to the MLT is reduced. This results in a net westward response in gravity wave drag, peaking at ~10 m s-1 d-1 in the SH high-latitude MLT. These changes in gravity wave drag modify the wave-induced residual circulation, and this contributes to the warming of ~1-4 K in the MLT.

  17. Understanding the 11-year Solar Cycle Signal in Stratospheric Ozone using a 3D CTM

    NASA Astrophysics Data System (ADS)

    Dhomse, Sandip; Chipperfield, Martyn; Feng, Wuhu

    2014-05-01

    The exact structure of the 11-year solar cycle signal in stratospheric ozone is still an open scientific question. Long-term satellite data such as Stratospheric Aerosol and Gas Experiment (SAGE) and Solar Backscatter UltraViolet (SBUV) show a positive solar response in the tropical lower stratosphere and upper stratosphere/lower mesosphere (US/LM), but a negligible signal in the tropical middle stratosphere. On the other hand, Halogen Occultation Experiment (HALOE) measurements show a positive signal in the lower and middle stratosphere and smaller solar signal in the tropical US/LM. Currently most chemical models are able to simulate a "double-peak"-structured solar signal but the model simulated solar signals tend to show better agreement with the HALOE-derived solar signal than those from SBUV or SAGE measurements. Also, some recent studies argue that due to the significantly different solar variability during the recent solar cycle (23), the solar signal in the US/LM ozone is negative (out of phase with total solar irradiance changes) for this later period compared to previous solar cycles. We have used 3-D chemical transport model (CTM) simulations to better understand the possible mechanisms responsible for this discrepancy. Various model simulations have been performed for 1979-2012 time period using ERA-Interim meteorological fields as a dynamical forcing. Model output is sampled at collocated measurement points for three satellite instruments performing stratospheric ozone measurements using the solar occultation technique: SAGE II (1984-2005), HALOE (1992-2005) and Atmospheric Chemistry Experiment (ACE, 2003-present). Overall the modelled ozone shows good agreement with all the data sets. However, in the US/LM, modelled ozone anomalies are better correlated with HALOE and ACE than SAGE II measurements. Hence the modelled solar signal in the stratospheric and lower mesospheric ozone also shows better agreement with the solar signal derived using HALOE and

  18. Observations and analysis of the Ionospheric Alfven resonance mode structure in a complete 11-year solar cycle

    NASA Astrophysics Data System (ADS)

    Baru, N. A.; Koloskov, A. V.; Yampolsky, Y. M.; Rakhmatulin, R. A.

    2016-03-01

    The long-term data of the ionospheric Alfven resonance (IAR) observations recorded at the Ukrainian Antarctic Station "Akademik Vernadsky" from 2002 to 2013 and at Sayan Solar Observatory (Mondy, Russia) from 2010 to 2013 are analyzed. IAR fine spectral structure is studied and a previously unknown effect of splitting of the several lowest resonance modes is discovered. The diurnal and seasonal dependencies of this effect are investigated as well as the dependences of the probability of IAR and splitting detection on Solar and geomagnetic activities in the 11-year cycle. The morphological features of the splitting frequency behavior are analyzed and three main characteristic periods of the splitting are identified, namely: the development, the stationary period and the disappearing. Possible mechanisms of the splitting effect are suggested.

  19. Cyclicity of Suicides May Be Modulated by Internal or External - 11-Year Cycles: An Example of Suicide Rates in Finland

    NASA Astrophysics Data System (ADS)

    Dimitrov, B. D.; Atanassova, P. A.; Rachkova, M. I.

    2009-12-01

    Multicomponent cyclicity in monthly suicides (periods T = 18, 46 and 198 months) was found and close similarity with heliogeophysical activity (HGA) suggested by Dimitrov in 1999. The current report aimed at scrutinizing the results on suicide annual cyclicity (seasonality) in Slovenia as reported by Oravecz et al in 2007 as well as at analyzing suicide data from Finland in this regard. We postulated that: (i) trans-year (12-24 months) or far-trans-year long-term cycles of suicides might interfere with their seasonality; and (ii) associations to environmental factors with alike cyclicity (e.g. HGA, temperature) could exist. Annual suicide incidence from Oulu, Finland over years 1987-1999 was analyzed. Annual data on solar activity (sunspot index Rz or Wolf number), planetary geomagnetic activity (aa-index) and local daily mean temperatures were used. The exploration of underlying chronomes (time structures) was done by periodogram regression analysis with trigonometric approximation. We analyzed temporal dynamics, revealed cyclicity, decomposed and reconstructed significant cycles and correlated the time series data. Suicide seasonality in Slovenia during the years 1971-2002 (n=384 months, peak May-June) was considered and, although some discrepancies and methodological weaknesses were suspected, we further hypothesized about trans-year and/or longer (far-transyear) cyclic components. Suicide incidence data from Finland indicated that the 12.5-year cyclic component (or trend) was almost parallel (coherent) to the cyclic heliogeophysical parameters and similar to local decreasing temperature dynamics. Also, 8-year and 24.5-year cycles were revealed. A correlation between the 12.5-year suicide cycle and 11-year solar cycle was found (R=0.919, p=0.000009). Above findings on cyclicity and temporal correlations of suicides with cyclic environmental factors, even being still preliminary, might not only allow for further more specific analyses. They might also corroborate

  20. Pathways Linking Perceived Athletic Competence and Parental Support at Age 9 Years to Girls' Physical Activity at Age 11 Years

    ERIC Educational Resources Information Center

    Davison, Kirsten Krahnstoever; Downs, Danielle Symons; Birch, Leann L.

    2006-01-01

    Girls' perceived athletic competence and parental support of physical activity across the ages of 9 to 11 years were examined as predictors of girls' physical activity at age 11 years. Participants were 174 girls and their mothers and fathers who completed questionnaires when the girls were ages 9 and 11 years. Two alternative temporal pathways…

  1. Peculiarities of the fine structure of the 11-year cyclicity of solar activity

    SciTech Connect

    Voichishin, K.S.

    1981-01-01

    Substantiation is given for the concept of cyclicity, at the basis of which lie such characteristic features of heliophysical time series as stochasticity, discontinuity, and stability of the shape of the cycles. A conceptual and formal apparatus is developed for the description and analysis of cyclic oscillations. A simple model of cyclicity with disturbances of the phase structure and without them is analyzed on a heuristic level of rigor. The results of an investigation of the monthly fluctuations of Wolf numbers obtained within the framework of this model are presented. A connection between the quasideterminate amplitude component of the monthly fluctuations of Wolf numbers in the range of periods of from 2 to 15 months and the 11-year component is confirmed. It is shown that the fine structure of the 11-year averaged cycle of monthly average Wolf numbers is determined mainly by the almost-yearly quasideterminate component. The possibility of discontinuity (from cycle to cycle) in the quasi-determinate component of the above-mentioned fluctuations is pointed out.

  2. Altitude dependent sensitivity of equatorial atomic oxygen in the MLT region to the quasi-11-year and quasi-27-day solar cycles

    NASA Astrophysics Data System (ADS)

    Lednyts'kyy, Olexandr; Von Savigny, Christian

    2016-07-01

    We retrieved atomic oxygen concentration ([O]) profiles with help of volume emission rate (VER) profiles calculated from the measured by SCIAMACHY (SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY) emissions of green line nightglow in the MLT (Mesosphere/Lower Thermosphere) region. We quantified the sensitivity of equatorial [O] to the 11-year and 27-day solar cycle forcing represented by such proxy indicators of solar activity as MgII index and Lyman-α with help of the wavelet, cross-correlation, superposed epoch, regression and harmonical analysis methods. We applied ordinary least squares bisector fitting on MgII index and F10.7 radio flux, which is measured in solar flux units (sfu), to convert the [O] sensitivity values in sfu and finally in percent changes. The same procedure was performed in the case of Lyman-α. Our results of the sensitivity analysis correspond well to the 11-year solar cycle response of O volume mixing ratios found in simulations performed with the WACCM3 (Whole Atmosphere Community Climate Model, v. 3) and the HAMMONIA (3D Hamburg Model of the Neutral and Ionized Atmosphere) model. We identified an 11-year solar cycle variation, quasi-biennial and annual/semi-annual oscillations as well as signatures of the 27-day cycle of solar activity as presented in the MLT O layer. The most remarkable result is that the found sensitivities agree within their uncertainties and do not depend on averaging method (annual, monthly and daily) of the [O] time series. We report on 11-year and 27-day solar cycle signatures in dependence on altitude intervals used to average the [O] time series.

  3. Relativistic electrons in the outer-zone: An 11 year cycle, their relation to the solar wind

    SciTech Connect

    Belian, R.D.; Cayton, T.E.; Christensen, R.A.; Ingraham, J.C.; Meier, M.M.; Reeves, G.D.; Lazarus, A.J.

    1994-12-31

    We examine Los Alamos energetic electron data from 1979 through the present to show long term trends in the trapped relativistic electron populations at geosynchronous-earth-orbit (GEO). Data is examined from several CPA and SOPA instruments to cover the interval from 1979 through June 1994. It is shown that the higher energy electrons fluxes (E > 300 keV) displayed a cycle of {approx}11 years. In agreement with other investigators, we also show that the relativistic electron cycle is out of phase with the sunspot cycle. We compare the occurrences of relativistic electrons and solar wind high speed streams and determine that on the time scale of 15 years the two do not correlate well. The long-term data set we provide here shows a systematic change of the electron energy spectrum during the course of the solar cycle. This information should be useful to magnetospheric scientists, model designers and space flight planners.

  4. The Antarctic ozone minimum - Relationship to odd nitrogen, odd chlorine, the final warming, and the 11-year solar cycle

    NASA Technical Reports Server (NTRS)

    Callis, L. B.; Natarajan, M.

    1986-01-01

    Photochemical calculations along 'diabatic trajectories' in the meridional phase are used to search for the cause of the dramatic springtime minimum in Antarctic column ozone. The results indicate that the minimum is principally due to catalytic destruction of ozone by high levels of total odd nitrogen. Calculations suggest that these levels of odd nitrogen are transported within the polar vortex and during the polar night from the middle to upper stratosphere and lower mesosphere to the lower stratosphere. The possibility that these levels are related to the 11-year solar cycle and are increased by enhanced formation in the thermosphere and mesosphere during solar maximum conditions is discussed.

  5. Climate variability related to the 11 year solar cycle as represented in different spectral solar irradiance reconstructions

    NASA Astrophysics Data System (ADS)

    Kruschke, Tim; Kunze, Markus; Misios, Stergios; Matthes, Katja; Langematz, Ulrike; Tourpali, Kleareti

    2016-04-01

    shortwave heating rate differences (additionally collated with line-by-line calculations using libradtran), differences in the photolysis rates, as well as atmospheric circulation features (temperature, zonal wind, geopotential height, etc.). It is shown that atmospheric responses to the different SSI datasets differ significantly from each other. This is a result from direct radiative effects as well as indirect effects induced by ozone feedbacks. Differences originating from using different SSI datasets for the same level of solar activity are in the same order of magnitude as those associated with the 11 year solar cycle within a specific dataset. However, the climate signals related to the solar cycle are quite comparable across datasets.

  6. New 1982-1990 photometry of Lambda Andromedae and its 11-year cycle

    NASA Technical Reports Server (NTRS)

    Hall, Douglas S.; Henry, Gregory W.; Boehme, Dietmar; Brooks, Peter A.; Chang, Sandy; Dolzan, Ales; Fortier, George L.; Fried, Robert E.; Genet, Russell M.; Grim, Bruce S.

    1991-01-01

    The paper presents photoelectric photometry of Lambda And never before published, obtained between February 1982 and December 1990 at 29 different observatories. Then it is combined with all other photometry available (previously published, contained in the I.A.U. Commission 27 Archives, and obtained with the Vanderbilt 16-inch automatic telescope but not yet published), to yield a 14.8-year data base. Analysis reveals a long-term cycle in mean brightness, with a full range of 0.15 m and a period of 11.4 +/- 0.4 years. Because most of the new photometry was concentrated in the 1983-1984 observing season, this one well-defined light curve is analyzed with a two-spot model. Spot A keeps a 0.04 m amplitude throughout four rotation cycles whereas the amplitude of spot B diminishes from 0.09 m down almost to 0.03 m. The spot rotation periods were 55.9 d +/- 0.6 d and 52.8 d +/- 1.0 d, respectively.

  7. On dependence of seismic activity on 11 year variations in solar activity and/or cosmic rays

    NASA Astrophysics Data System (ADS)

    Zhantayev, Zhumabek; Khachikyan, Galina; Breusov, Nikolay

    2014-05-01

    It is found in the last decades that seismic activity of the Earth has a tendency to increase with decreasing solar activity (increasing cosmic rays). A good example of this effect may be the growing number of catastrophic earthquakes in the recent rather long solar minimum. Such results support idea on existence a solar-lithosphere relationship which, no doubts, is a part of total pattern of solar-terrestrial relationships. The physical mechanism of solar-terrestrial relationships is not developed yet. It is believed at present that one of the main contenders for such mechanism may be the global electric circuit (GEC) - vertical current loops, piercing and electrodynamically coupling all geospheres. It is also believed, that the upper boundary of the GEC is located at the magnetopause, where magnetic field of the solar wind reconnects with the geomagnetic field, that results in penetrating solar wind energy into the earth's environment. The effectiveness of the GEC operation depends on intensity of cosmic rays (CR), which ionize the air in the middle atmosphere and provide its conductivity. In connection with the foregoing, it can be expected: i) quantitatively, an increasing seismic activity from solar maximum to solar minimum may be in the same range as increasing CR flux; and ii) in those regions of the globe, where the crust is shipped by the magnetic field lines with number L= ~ 2.0, which are populated by anomalous cosmic rays (ACR), the relationship of seismic activity with variations in solar activity will be manifested most clearly, since there is a pronounced dependence of ACR on solar activity variations. Checking an assumption (i) with data of the global seismological catalog of the NEIC, USGS for 1973-2010, it was found that yearly number of earthquake with magnitude M≥4.5 varies into the 11 year solar cycle in a quantitative range of about 7-8% increasing to solar minimum, that qualitatively and quantitatively as well is in agreement with the

  8. [Unevenness of distribution of historical events throughout an 11-year solar cycle].

    PubMed

    Putilov, A A

    1992-01-01

    Tchizhevsky hypothesis (1922) of historical process heliotaraxia (helios--sun, taracsio--perturb) was empirically tested. Samples of near 13 and 4.6 thousand events mentioned in Chronology sections of two largest Soviet historical handbooks were analyzed. Events were classified into 4 groups on the basis of "strength" and "social contradictions meaning" of their names, called tolerance and polarity: tolerant--intolerant (e.f. riot--roform) and polar--neutral (e.f. civil war-external war). It was found that frequency and polarity of historical events increased in maximum of sunspot cycle and in the next year as compared with minimum and the year before minimum. The probability of revolution (the most polar and intolerant name of historical event) is the highest in maximum and the lowest in the year before minimum. Intolerance of polar events increased and neutral events decreased in maximum. All these relations were highly significant (P < 0.001). It was concluded that heliotaraxic phenomena exist and are basically associated with year of sunspot maximum. PMID:1420416

  9. 11-year solar cycle in Schumann resonance data as observed in Antarctica

    NASA Astrophysics Data System (ADS)

    Nickolaenko, A. P.; Koloskov, A. V.; Hayakawa, M.; Yampolski, Yu. M.; Budanov, O. V.; Korepanov, V. E.

    2015-03-01

    Studies of Schumann resonance allows obtaining characteristics of the lower ionosphere and the dynamics of global thunderstorms based on the data recorded at a single or a few ground-based observatories. We use the simple model of a point source. The vertical profile of air conductivity is described by the "knee" model. We used continuous Schumann resonance record from the "Akademik Vernadsky" Ukrainian Antarctic station (geographic coordinates: 65.25S and 64.25W, L=2.6). A data processing show that the north-south seasonal drift of global thunderstorms was about 20°, and the intensity of global lightning activity changed annually by the factor 1.5-2. Unequal duration of the "electromagnetic" seasons was confirmed ("summer" ~ 120 days, "winter" ~ 60 days; duration of the "spring" is shorter than the "fall"). A possible explanation of inter-annual variations of Schumann resonance parameter follows from changes in the effective height of the lower ionosphere. In this case, we used the spatial thunderstorm distribution following from the annual data of the Optical Transient Detector satellite. We show that recorded inter-annual variations of resonance frequencies and intensities might be attributed to 1-2 km alterations in the knee height of ionosphere. The most realistic mechanism of changes should include both the height variations and the drift of global thunderstorms. Both the processes are governed by solar activity. We also estimated the feasible trend in the equatorial soil surface temperature by 1.6° C corresponding to the inter-annual change of Schumann resonance intensity.

  10. Relativistic electrons in the outer-zone: An 11 year cycle; Their relation to the solar wind

    SciTech Connect

    Belian, R.D.; Cayton, T.E.; Christensen, R.A.; Ingraham, J.C.; Meier, M.M.; Reeves, G.D.; Lazarus, A.J.

    1996-07-01

    We examine Los Alamos energetic electron data from 1979 through the present to show long term trends in the trapped relativistic electron populations at geosynchronous-earth-orbit (GEO). Data is examined from several CPA and SOPA instruments to cover the interval from 1979 through June, 1994. It is shown that the higher energy electrons fluxes ({ital E}{gt}300 keV) displayed a cycle of {approx_equal}11 years. In agreement with other investigators, we also show that the relativistic electron cycle is out of phase with the sunspot cycle. We compare the occurrences of relativistic electrons and solar wind high speed streams and determine that on the time scale of 15 years the two do not correlate well. The long-term data set we provide here shows a systematic change of the electron energy spectrum during the course of the solar cycle. This information should be useful to magnetospheric scientists, model designers and space flight planners. {copyright} {ital 1996 American Institute of Physics.}

  11. Schoolyard physical activity of 6–11 year old children assessed by GPS and accelerometry

    PubMed Central

    2013-01-01

    Background Children’s current physical activity levels are disturbingly low when compared to recommended levels. This may be changed by intervening in the school environment. However, at present, it is unclear to what extent schoolyard physical activity contributes towards reaching the daily physical activity guideline. The aim of this study was to examine how long and at what intensity children are physically active at the schoolyard during different time segments of the day. Moreover, the contribution of schoolyard physical activity towards achieving the recommended guideline for daily physical activity was investigated. Methods Children (n=76) between the age of 6–11 years were recruited in six different schools in five cities (>70.000 residents) in the Netherlands. During the weekdays of a regular school week, childrens’ physical activity and location were measured with ActiGraph accelerometers and Travelrecorder GPS receivers. Data was collected from December 2008 to April 2009. From the data, the amount of moderate to vigorous physical activity (MVPA) on and outside the schoolyard was established. Moreover, the percentage of MVPA on the schoolyard was compared between the following segments of the day: pre-school, school, school recess, lunch break and post-school. Differences between boys and girls were compared using linear and logistic mixed-effects models. Results On average, children spent 40.1 minutes/day on the schoolyard. During this time, boys were more active on the schoolyard, with 27.3% of their time spent as MVPA compared to 16.7% among girls (OR=2.11 [95% CI 1.54 - 2.90]). The children were most active on the schoolyard during school recess, during which boys recorded 39.5% and girls recorded 23.4% of the time as MVPA (OR=2.55 [95% CI: 1.69 - 3.85]). Although children were only present at the schoolyard for 6.1% of the total reported time, this time contributed towards 17.5% and 16.8% of boys’ and girls’ minutes of MVPA. Conclusions On

  12. Global correlation between surface heat fluxes and insolation in the 11-year solar cycle: The latitudinal effect

    NASA Astrophysics Data System (ADS)

    Volobuev, D. M.; Makarenko, N. G.

    2014-12-01

    Because of the small amplitude of insolation variations (1365.2-1366.6 W m-2 or 0.1%) from the 11-year solar cycle minimum to the cycle maximum and the structural complexity of the climatic dynamics, it is difficult to directly observe a solar signal in the surface temperature. The main difficulty is reduced to two factors: (1) a delay in the temperature response to external action due to thermal inertia, and (2) powerful internal fluctuations of the climatic dynamics suppressing the solar-driven component. In this work we take into account the first factor, solving the inverse problem of thermal conductivity in order to calculate the vertical heat flux from the measured temperature near the Earth's surface. The main model parameter—apparent thermal inertia—is calculated from the local seasonal extremums of temperature and albedo. We level the second factor by averaging mean annual heat fluxes in a latitudinal belt. The obtained mean heat fluxes significantly correlate with a difference between the insolation and optical depth of volcanic aerosol in the atmosphere, converted into a hindered heat flux. The calculated correlation smoothly increases with increasing latitude to 0.4-0.6, and the revealed latitudinal dependence is explained by the known effect of polar amplification.

  13. Upper School Maths: Lesson Plans and Activities for Ages 9-11 Years. Series of Caribbean Volunteer Publications, No. 9.

    ERIC Educational Resources Information Center

    Voluntary Services Overseas, Castries (St. Lucia).

    This collection of lesson plans and activities for students aged 9-11 years is based on a science curriculum developed by a group of Caribbean nations. The activities pertain to topics such as place value, prime and composite numbers, the sieve of Eratosthenes, square numbers, factors and multiples, sequences, averages, geometry, symmetry,…

  14. Predictors of Meeting Physical Activity and Fruit and Vegetable Recommendations in 9-11-Year-Old Children

    ERIC Educational Resources Information Center

    Beck, Jimikaye; De Witt, Peter; McNally, Janise; Siegfried, Scott; Hill, James O; Stroebele-Benschop, Nanette

    2015-01-01

    Objective: Childhood obesity represents a significant public health problem. This study examined physical activity and nutrition behaviours and attitudes of 9-11-year-olds, and factors influencing these behaviours. Design: Study participants recorded pedometer steps for 7 days and completed physical activity enjoyment, food attitudes and food…

  15. Evaluation of Low-Cost, Objective Instruments for Assessing Physical Activity in 10-11-Year-Old Children

    ERIC Educational Resources Information Center

    Hart, Teresa L.; Brusseau, Timothy; Kulinna, Pamela Hodges; McClain, James J.; Tudor-Locke, Catrine

    2011-01-01

    This study compared step counts detected by four, low-cost, objective, physical-activity-assessment instruments and evaluated their ability to detect moderate-to-vigorous physical activity (MVPA) compared to the ActiGraph accelerometer (AG). Thirty-six 10-11-year-old children wore the NL-1000, Yamax Digiwalker SW 200, Omron HJ-151, and Walk4Life…

  16. Licence to be active: parental concerns and 10–11-year-old children's ability to be independently physically active

    PubMed Central

    Jago, Russell; Thompson, Janice L.; Page, Angie S.; Brockman, Rowan; Cartwright, Kim; Fox, Kenneth R.

    2009-01-01

    Background Physical activity independent of adult supervision is an important component of youth physical activity. This study examined parental attitudes to independent activity, factors that limit licence to be independently active and parental strategies to facilitate independent activity. Methods In-depth phone interviews were conducted with 24 parents (4 males) of 10–11-year-old children recruited from six primary schools in Bristol. Results Parents perceived that a lack of appropriate spaces in which to be active, safety, traffic, the proximity of friends and older children affected children's ability to be independently physically active. The final year of primary school was perceived as a period when children should be afforded increased licence. Parents managed physical activity licence by placing time limits on activity, restricting activity to close to home, only allowing activity in groups or under adult supervision. Conclusions Strategies are needed to build children's licence to be independently active; this could be achieved by developing parental self-efficacy to allow children to be active and developing structures such as safe routes to parks and safer play areas. Future programmes could make use of traffic-calming programmes as catalysts for safe independent physical activity. PMID:19505927

  17. 11-year cycle solar modulation of cosmic ray intensity inferred from C-14 content variation in dated tree rings

    NASA Technical Reports Server (NTRS)

    Fan, C. Y.; Chen, T. M.; Yun, S. X.; Dai, K. M.

    1983-01-01

    A liquid scintillation-photomultiplier tube counter system was used to measure the Delta-C-14 values of 60 tree rings, dating from 1866 to 1925, that were taken from a white spruce grown in Canada at 68 deg N, 130 deg W. A 10-percent variation is found which is anticorrelated with sunspot numbers, although the amplitude of the variation is 2-3 times higher than expected in trees grown at lower latitudes. A large dip in the data at about 1875 suggests an anomalously large modulation of cosmic ray intensity during the 1867-1878 AD solar cycle, which was the most active of the 19th century.

  18. Effect of the Great Activity Programme on healthy lifestyle behaviours in 7-11 year olds.

    PubMed

    Morris, John G; Gorely, Trish; Sedgwick, Matthew J; Nevill, Alan; Nevill, Mary E

    2013-01-01

    The study investigated the effect of a school-based healthy lifestyles intervention on physical activity and dietary variables. In total 378 children (177 intervention, 201 control; age 9.75 ± 0.82 years (mean ± s)) took part in the 7-month intervention comprising: preparation for and participation in 3 highlight events (a dance festival, a walking event and a running event); an interactive website for pupils, teachers and parents; and vacation activity planners. Primary outcome measures were objectively measured physical activity (pedometers and accelerometers), endurance fitness and dietary variables. Multi-level modelling was employed for data analysis. The increase in physical activity was greater in the intervention group than the control group (steps: 1049 vs 632 daily steps each month; moderate to vigorous physical activity (MVPA) total: 4.6 min · day(-1) · month(-1) vs 1.3 min · day(-1) · month(-1); MVPA bouts: 5.4 min · day(-1) · month(-1) vs 2.6 min · day(-1) · month(-1); all P < 0.05). The increase in multi-stage fitness test distance was greater for intervention participants (46 vs 29 m · month(-1) of intervention, group × month interaction, P < 0.05). There were no differences between groups in dietary variables, body composition, knowledge of healthy lifestyles or psychological variables. Thus an intervention centred around highlight events and including relatively few additional resources can impact positively on the objectively measured physical activity of children. PMID:23656302

  19. Prospective Associations Between Leisure-Time Physical Activity and Cognitive Performance Among Older Adults Across an 11-Year Period

    PubMed Central

    Ku, Po-Wen; Stevinson, Clare; Chen, Li-Jung

    2012-01-01

    Background Few studies have explored the relations between naturally occurring changes in physical activity and cognitive performance in later life. This study examined prospective associations between changes in physical activity and cognitive performance in a population-based sample of Taiwanese older adults during an 11-year period. Methods Analyses were based on nationally representative data from the Taiwan Health and Living Status of the Elderly Survey collected in 1996, 1999, 2003, and 2007. Data from a fixed cohort of 1160 participants who were aged 67 years or older in 1996 and followed for 11 years were included. Cognitive performance (outcome) was assessed using 5 questions from the Short Portable Mental Status Questionnaire. Physical activity (exposure) was self-reported as number of sessions per week. The latent growth model was used to examine associations between changes in physical activity and cognitive performance after controlling for sociodemographic variables, lifestyle behaviors, and health status. Results With multivariate adjustment, higher initial levels of physical activity were significantly associated with better initial cognitive performance (standardized coefficient β = 0.17). A higher level of physical activity at baseline (1996) was significantly related to slower decline in cognitive performance, as compared with a lower level of activity (β = 0.22). The association between changes in physical activity and changes in cognitive performance was stronger (β = 0.36) than the previous 2 associations. The effect remained after excluding participants with cognitive decline before baseline. Conclusions Physical activity in later life is associated with slower age-related cognitive decline. PMID:22343329

  20. Active school transport and weekday physical activity in 9–11-year-old children from 12 countries

    PubMed Central

    Denstel, K D; Broyles, S T; Larouche, R; Sarmiento, O L; Barreira, T V; Chaput, J-P; Church, T S; Fogelholm, M; Hu, G; Kuriyan, R; Kurpad, A; Lambert, E V; Maher, C; Maia, J; Matsudo, V; Olds, T; Onywera, V; Standage, M; Tremblay, M S; Tudor-Locke, C; Zhao, P; Katzmarzyk, P T

    2015-01-01

    OBJECTIVES: Active school transport (AST) may increase the time that children spend in physical activity (PA). This study examined relationships between AST and weekday moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary time (SED) and total activity during naturally organized time periods (daily, before school, during school and after school) in a sample of children from 12 countries. METHODS: The sample included 6224 children aged 9–11 years. PA and sedentary time were objectively measured using Actigraph accelerometers. AST was self-reported by participants. Multilevel generalized linear and logistic regression statistical models were used to determine associations between PA, SED and AST across and within study sites. RESULTS: After adjustment for age, highest parental educational attainment, BMI z-score and accelerometer wear time, children who engaged in AST accumulated significantly more weekday MVPA during all studied time periods and significantly less time in LPA before school compared with children who used motorized transport to school. AST was unrelated to time spent in sedentary behaviors. Across all study sites, AST was associated with 6.0 min (95% confidence interval (CI): 4.7–7.3; P<0.0001) more of weekday MVPA; however, there was some evidence that this differed across study sites (P for interaction=0.06). Significant positive associations were identified within 7 of 12 study sites, with differences ranging from 4.6 min (95% CI: 0.3–8.9; P=0.04, in Canada) to 10.2 min (95% CI: 5.9–14.4; P<0.0001, in Brazil) more of daily MVPA among children who engaged in AST compared with motorized transport. CONCLUSIONS: The present study demonstrated that AST was associated with children spending more time engaged in MVPA throughout the day and less time in LPA before school. AST represents a good behavioral target to increase levels of PA in children. PMID:27152177

  1. The possible mechanism of the "stratospheric bridge" modulation by the Pacific Decadal Oscillation in early winter and the QBO, 11-year solar cycle in late winter

    NASA Astrophysics Data System (ADS)

    Jadin, Evgeny; Wei, Ke; Chen, Wen; Wang, Lin

    Questions of the interannual variations of the extra-tropical stratospheric dynamics, its rela-tionship with the sea surface temperature (SST) anomalies in the North Pacific (Pacific Decadal Oscillation -PDO) in early winter (November-December), Quasi-Biennial Oscillation (QBO) (Holton-Tan relations), a decadal modulation by the 11-year Solar Cycle (SC) (Labitzke, van Loon -LvL correlations) in late winter (January-February) are discussed. In early winter, the interannual changes of the planetary wave activity define partly the variations of the strato-spheric circulation in subsequent January [Zyulyaeva and Jadin, 2009]. The interannual and decadal variations of the stratospheric wave activity appear to be associated with those of the PDO [Jadin et al. 2009]. A decadal period from the mid-1970s to mid-1990s of the violation of the Holton-Tan (HT) relationship corresponds well to that of the positive PDO phase (anoma-lously cold SSTs in the central North Pacific). Using the NCEP and ERA-40 monthly mean reanalysis datasets, the three-dimensional Eliassen-Palm fluxes are calculated. The results of the analysis of relations between the upward/downward propagation of planetary waves in the lower stratosphere ("stratospheric bridge"), their interaction with the zonal wind and the HT and LvL correlations for January-February are presented. In contrast with early winter, the large role in the wave-zonal flow interaction plays the downward propagation of planetary waves from the stratosphere to the troposphere over Canada and North Atlantic ("stratospheric wave hole") responsible for the sink of the eddy energy from the stratosphere. One can suggest that there are two dominant regimes in the stratosphere-troposphere coupling in late winter: 1) the "ventilation regime" with the strong penetration of planetary waves from the troposphere over north Eurasia and their strong downward propagation over Canada and North Atlantic, and 2) the "blocking regime" with the weak those

  2. Four minutes of in-class high-intensity interval activity improves selective attention in 9- to 11-year olds.

    PubMed

    Ma, Jasmin K; Le Mare, Lucy; Gurd, Brendon J

    2015-03-01

    The amount of time allocated to physical activity in schools is declining. Time-efficient physical activity solutions that demonstrate their impact on academic achievement-related outcomes are needed to prioritize physical activity within the school curricula. "FUNtervals" are 4-min, high-intensity interval activities that use whole-body actions to complement a storyline. The purpose of this study was to (i) explore whether FUNtervals can improve selective attention, an executive function posited to be essential for learning and academic success; and (ii) examine whether this relationship is predicted by students' classroom off-task behaviour. Seven grade 3-5 classes (n = 88) were exposed to a single-group, repeated cross-over design where each student's selective attention was compared between no-activity and FUNtervals days. In week 1, students were familiarized with the d2 test of attention and FUNterval activities, and baseline off-task behaviour was observed. In both weeks 2 and 3 students completed the d2 test of attention following either a FUNterval break or a no-activity break. The order of these breaks was randomized and counterbalanced between weeks. Neither motor nor passive off-task behaviour predicted changes in selective attention following FUNtervals; however, a weak relationship was observed for verbal off-task behaviour and improvements in d2 test performance. More importantly, students made fewer errors during the d2 test following FUNtervals. In supporting the priority of physical activity inclusion within schools, FUNtervals, a time efficient and easily implemented physical activity break, can improve selective attention in 9- to 11-year olds. PMID:25675352

  3. Middle Atmosphere Response to Different Descriptions of the 11-Year Solar Cycle in Spectral Irradiance in a Chemistry-Climate Model

    NASA Technical Reports Server (NTRS)

    Swartz, W. H.; Stolarski, R. S.; Oman, L. D.; Fleming, E. L.; Jackman, C. H.

    2012-01-01

    The 11-year solar cycle in solar spectral irradiance (SSI) inferred from measurements by the SOlar Radiation & Climate Experiment (SORCE) suggests a much larger variation in the ultraviolet than previously accepted. We present middle atmosphere ozone and temperature responses to the solar cycles in SORCE SSI and the ubiquitous Naval Research Laboratory (NRL) SSI reconstruction using the Goddard Earth Observing System chemistry-climate model (GEOS CCM). The results are largely consistent with other recent modeling studies. The modeled ozone response is positive throughout the stratosphere and lower mesosphere using the NRL SSI, while the SORCE SSI produces a response that is larger in the lower stratosphere but out of phase with respect to total solar irradiance above 45 km. The modeled responses in total ozone are similar to those derived from satellite and ground-based measurements, 3-6 Dobson Units per 100 units of 10.7-cm radio flux (F10.7) in the tropics. The peak zonal mean tropical temperature response 50 using the SORCE SSI is nearly 2 K per 100 units 3 times larger than the simulation using the NRL SSI. The GEOS CCM and the Goddard Space Flight Center (GSFC) 2-D coupled model are used to examine how the SSI solar cycle affects the atmosphere through direct solar heating and photolysis processes individually. Middle atmosphere ozone is affected almost entirely through photolysis, whereas the solar cycle in temperature is caused both through direct heating and photolysis feedbacks, processes that are mostly linearly separable. Further, the net ozone response results from the balance of ozone production at wavelengths less than 242 nm and destruction at longer wavelengths, coincidentally corresponding to the wavelength regimes of the SOLar STellar Irradiance Comparison Experiment (SOLSTICE) and Spectral Irradiance Monitor (SIM) on SORCE, respectively. A higher wavelength-resolution analysis of the spectral response could allow for a better prediction of the

  4. Soil carbon and nitrogen cycling and storage throughout the soil profile in a sweetgum plantation after 11 years of CO2-enrichment

    SciTech Connect

    Iversen, Colleen M; Keller, Dr. Jason K.; Garten Jr, Charles T; Norby, Richard J

    2012-01-01

    Increased partitioning of carbon (C) to fine roots under elevated [CO2], especially deep in the soil profile, could alter soil C and nitrogen (N) cycling in forests. After more than 11 years of free-Air CO2 enrichment in a Liquidambar styraciflua L. (sweetgum) plantation in Oak Ridge, TN, USA, greater inputs of fine roots resulted in the incorporation of new C (i.e., C with a depleted 13C) into root-derived particulate organic matter (POM) pools to 90-cm depth. Even though production in the sweetgum stand was limited by soil N availability, soil C and N content increased over time, and were greater throughout the soil profile under elevated [CO2] at the conclusion of the experiment. However, greater C inputs under elevated [CO2] did not result in increased net N immobilization or C mineralization rates in long-term laboratory incubations, and did not appear to prime the decomposition of older SOM. The 13CO2 of the C mineralized from the incubated soil closely tracked the 13C of the labile POM pool in the elevated [CO2] treatment, especially in shallower soil, and did not indicate the decomposition of older (i.e., pre-experiment) SOM. While potential C mineralization rates were positively and linearly related to total soil organic matter (SOM) C content in the top 30 cm of soil, this relationship did not hold in deeper soil. Taken together with an increased mean residence time of C in deeper soil pools, these findings indicate that C inputs from relatively deep roots under elevated [CO2] may have increased potential for long-term storage. Expanded representation of biogeochemical cycling throughout the soil profile may improve model projections of future forest responses to rising atmospheric [CO2].

  5. School related factors and 1yr change in physical activity amongst 9–11 year old English schoolchildren

    PubMed Central

    2012-01-01

    Background Activity levels are known to decline with age and there is growing evidence of associations between the school environment and physical activity. In this study we investigated how objectively measured one-year changes in physical activity may be associated with school-related factors in 9- to 10-year-old British children. Methods Data were analysed from 839 children attending 89 schools in the SPEEDY (Sport, Physical Activity, and Eating behaviours: Environmental Determinants in Young People) study. Outcomes variables were one year changes in objectively measured sedentary, moderate, and vigorous physical activity, with baseline measures taken when the children were 9–10 years old. School characteristics hypothesised to be associated with change in physical activity were identified from questionnaires, grounds audits, and computer mapping. Associations were examined using simple and multivariable multilevel regression models for both school (9 am – 3 pm) and travel (8–9 am and 3–4 pm) time. Results Significant associations during school time included the length of the morning break which was found to be supportive of moderate (β coefficient: 0.68 [p: 0.003]) and vigorous (β coefficient: 0.52 [p: 0.002]) activities and helps to prevent adverse changes in sedentary time (β coefficient: -2.52 [p: 0.001]). During travel time, positive associations were found between the presence of safe places to cross roads around the school and changes in moderate (β coefficient: 0.83 [p:0.022]) and vigorous (β coefficient: 0.56 [p:0.001]) activity, as well as sedentary time (β coefficient: -1.61 [p:0.005]). Conclusion This study suggests that having longer morning school breaks and providing road safety features such as cycling infrastructure, a crossing guard, and safe places for children to cross the road may have a role to play in supporting the maintenance of moderate and vigorous activity behaviours, and preventing the development of sedentary

  6. Hindcast and forecast of grand solar minina and maxima using a three-frequency dynamo model based on Jupiter-Saturn tidal frequencies modulating the 11-year sunspot cycle

    NASA Astrophysics Data System (ADS)

    Scafetta, Nicola

    2016-04-01

    The Schwabe frequency band of the Zurich sunspot record since 1749 is found to be made of three major cycles with periods of about 9.98, 10.9 and 11.86 years. The two side frequencies appear to be closely related to the spring tidal period of Jupiter and Saturn (range between 9.5 and 10.5 years, and median 9.93 years) and to the tidal sidereal period of Jupiter (about 11.86 years). The central cycle can be associated to a quasi-11-year sunspot solar dynamo cycle that appears to be approximately synchronized to the average of the two planetary frequencies. A simplified harmonic constituent model based on the above two planetary tidal frequencies and on the exact dates of Jupiter and Saturn planetary tidal phases, plus a theoretically deduced 10.87-year central cycle reveals complex quasi-periodic interference/beat patterns. The major beat periods occur at about 115, 61 and 130 years, plus a quasi-millennial large beat cycle around 983 years. These frequencies and other oscillations appear once the model is non-linearly processed. We show that equivalent synchronized cycles are found in cosmogenic records used to reconstruct solar activity and in proxy climate records throughout the Holocene (last 12,000 years) up to now. The quasi-secular beat oscillations hindcast reasonably well the known prolonged periods of low solar activity during the last millennium such as the Oort, Wolf, Sporer, Maunder and Dalton minima, as well as the 17 115-year long oscillations found in a detailed temperature reconstruction of the Northern Hemisphere covering the last 2000 years. The millennial cycle hindcasts equivalent solar and climate cycles for 12,000 years. Finally, the harmonic model herein proposed reconstructs the prolonged solar minima that occurred during 1900- 1920 and 1960-1980 and the secular solar maxima around 1870-1890, 1940-1950 and 1995-2005 and a secular upward trending during the 20th century: this modulated trending agrees well with some solar proxy model, with

  7. Comparison of short-term energy intake and appetite responses to active and seated video gaming, in 8-11-year-old boys.

    PubMed

    Allsop, Susan; Green, Benjamin P; Dodd-Reynolds, Caroline J; Barry, Gillian; Rumbold, Penny L S

    2016-03-28

    The acute effects of active and seated video gaming on energy intake (EI), blood glucose, plasma glucagon-like peptide-1 (GLP-17-36) and subjective appetite (hunger, prospective food consumption and fullness) were examined in 8-11-year-old boys. In a randomised, crossover manner, twenty-two boys completed one 90-min active and one 90-min seated video gaming trial during which food and drinks were provided ad libitum. EI, plasma GLP-17-36, blood glucose and subjective appetite were measured during and following both trials. Time-averaged AUC blood glucose was increased (P=0·037); however, EI was lower during active video gaming (1·63 (sem 0·26) MJ) compared with seated video gaming (2·65 (sem 0·32) MJ) (P=0·000). In a post-gaming test meal 1 h later, there were no significant differences in EI between the active and seated gaming trials. Although estimated energy expenditure was significantly higher during active video gaming, there was still no compensation for the lower EI. At cessation of the trials, relative EI (REI) was significantly lower following active video gaming (2·06 (sem 0·30) MJ) v. seated video gaming (3·34 (sem 0·35) MJ) (P=0·000). No significant differences were detected in time-averaged AUC GLP-17-36 or subjective appetite. At cessation of the active video gaming trial, EI and REI were significantly less than for seated video gaming. In spite of this, the REI established for active video gaming was a considerable amount when considering the total daily estimated average requirement for 8-11-year-old boys in the UK (7·70 MJ). PMID:26817510

  8. Physical activity and all-cause mortality among older Brazilian adults: 11-year follow-up of the Bambuí Health and Aging Study

    PubMed Central

    Ramalho, Juciany RO; Mambrini, Juliana VM; César, Cibele C; de Oliveira, César M; Firmo, Josélia OA; Lima-Costa, Maria Fernanda; Peixoto, Sérgio V

    2015-01-01

    Objective To investigate the association between physical activity (eg, energy expenditure) and survival over 11 years of follow-up in a large representative community sample of older Brazilian adults with a low level of education. Furthermore, we assessed sex as a potential effect modifier of this association. Materials and methods A population-based prospective cohort study was conducted on all the ≥60-year-old residents in Bambuí city (Brazil). A total of 1,606 subjects (92.2% of the population) enrolled, and 1,378 (85.8%) were included in this study. Type, frequency, and duration of physical activity were assessed in the baseline survey questionnaire, and the metabolic equivalent task tertiles were estimated. The follow-up time was 11 years (1997–2007), and the end point was mortality. Deaths were reported by next of kin during the annual follow-up interview and ascertained through the Brazilian System of Information on Mortality, Brazilian Ministry of Health. Hazard ratios (95% confidence intervals [CIs]) were estimated by Cox proportional-hazard models, and potential confounders were considered. Results A statistically significant interaction (P<0.03) was found between sex and energy expenditure. Among older men, increases in levels of physical activity were associated with reduced mortality risk. The hazard ratios were 0.59 (95% CI 0.43–0.81) and 0.47 (95% CI 0.34–0.66) for the second and third tertiles, respectively. Among older women, there was no significant association between physical activity and mortality. Conclusion It was possible to observe the effect of physical activity in reducing mortality risk, and there was a significant interaction between sex and energy expenditure, which should be considered in the analysis of this association in different populations. PMID:25931817

  9. Acute effects of active gaming on ad libitum energy intake and appetite sensations of 8-11-year-old boys.

    PubMed

    Allsop, Susan; Dodd-Reynolds, Caroline J; Green, Benjamin P; Debuse, Dorothée; Rumbold, Penny L S

    2015-12-28

    The present study examined the acute effects of active gaming on energy intake (EI) and appetite responses in 8-11-year-old boys in a school-based setting. Using a randomised cross-over design, twenty-one boys completed four individual 90-min gaming bouts, each separated by 1 week. The gaming bouts were (1) seated gaming, no food or drink; (2) active gaming, no food or drink; (3) seated gaming with food and drink offered ad libitum; and (4) active gaming with food and drink offered ad libitum. In the two gaming bouts during which foods and drinks were offered, EI was measured. Appetite sensations - hunger, prospective food consumption and fullness - were recorded using visual analogue scales during all gaming bouts at 30-min intervals and at two 15-min intervals post gaming. In the two bouts with food and drink, no significant differences were found in acute EI (MJ) (P=0·238). Significant differences were detected in appetite sensations for hunger, prospective food consumption and fullness between the four gaming bouts at various time points. The relative EI calculated for the two gaming bouts with food and drink (active gaming 1·42 (sem 0·28) MJ; seated gaming 2·12 (sem 0·25) MJ) was not statistically different. Acute EI in response to active gaming was no different from seated gaming, and appetite sensations were influenced by whether food was made available during the 90-min gaming bouts. PMID:26435259

  10. A comparison of physical activity and sedentary behaviour in 9–11 year old British Pakistani and White British girls: a mixed methods study

    PubMed Central

    2014-01-01

    Background Previous studies suggest that British children of South Asian origin are less active and more sedentary than White British children. However, little is known about the behaviours underlying low activity levels, nor the familial contexts of active and sedentary behaviours in these groups. Our aim was to test hypotheses about differences between British Pakistani and White British girls using accelerometry and self-reports of key active and sedentary behaviours, and to obtain an understanding of factors affecting these behaviours using parental interviews. Methods Participants were 145 girls (70 White British and 75 British Pakistani) aged 9–11 years and parents of 19 of the girls. Accelerometry data were collected over 4 days and girls provided 24-hour physical activity interviews on 3 of these days. Multilevel linear regression models and generalised linear mixed models tested for ethnic differences in activity, sedentary time, and behaviours. Semi-structured interviews were conducted with parents. Results Compared to White British girls, British Pakistani girls accumulated 102 (95% CI 59, 145) fewer counts per minute and 14 minutes (95% CI 8, 20) less time in moderate to vigorous physical activity per day. British Pakistani girls spent more time (28 minutes per day, 95% CI 14, 42) sedentary. Fewer British Pakistani than White British girls reported participation in organised sports and exercise (OR 0.22 95% CI 0.08, 0.64) or in outdoor play (OR 0.42 95% CI 0.20, 0.91). Fewer British Pakistani girls travelled actively to school (OR 0.26 95% CI 0.10, 0.71). There was no significant difference in reported screen time (OR 0.88 95% CI 0.45, 1.73). Parental interviews suggested that structural constraints (e.g. busy family schedules) and parental concerns about safety were important influences on activity levels. Conclusions British Pakistani girls were less active than White British girls and were less likely to participate in key active behaviours

  11. Relationships between Parental Education and Overweight with Childhood Overweight and Physical Activity in 9–11 Year Old Children: Results from a 12-Country Study

    PubMed Central

    Muthuri, Stella K.; Onywera, Vincent O.; Tremblay, Mark S.; Broyles, Stephanie T.; Chaput, Jean-Philippe; Fogelholm, Mikael; Hu, Gang; Kuriyan, Rebecca; Kurpad, Anura; Lambert, Estelle V.; Maher, Carol; Maia, José; Matsudo, Victor; Olds, Timothy; Sarmiento, Olga L.; Standage, Martyn; Tudor-Locke, Catrine; Zhao, Pei; Church, Timothy S.; Katzmarzyk, Peter T.

    2016-01-01

    Background Globally, the high prevalence of overweight and low levels of physical activity among children has serious implications for morbidity and premature mortality in adulthood. Various parental factors are associated with childhood overweight and physical activity. The objective of this paper was to investigate relationships between parental education or overweight, and (i) child overweight, (ii) child physical activity, and (iii) explore household coexistence of overweight, in a large international sample. Methods Data were collected from 4752 children (9–11 years) as part of the International Study of Childhood Obesity, Lifestyle and the Environment in 12 countries around the world. Physical activity of participating children was assessed by accelerometry, and body weight directly measured. Questionnaires were used to collect parents’ education level, weight, and height. Results Maternal and paternal overweight were positively associated with child overweight. Higher household coexistence of parent-child overweight was observed among overweight children compared to the total sample. There was a positive relationship between maternal education and child overweight in Colombia 1.90 (1.23–2.94) [odds ratio (confidence interval)] and Kenya 4.80 (2.21–10.43), and a negative relationship between paternal education and child overweight in Brazil 0.55 (0.33–0.92) and the USA 0.54 (0.33–0.88). Maternal education was negatively associated with children meeting physical activity guidelines in Colombia 0.53 (0.33–0.85), Kenya 0.35 (0.19–0.63), and Portugal 0.54 (0.31–0.96). Conclusions Results are aligned with previous studies showing positive associations between parental and child overweight in all countries, and positive relationships between parental education and child overweight or negative associations between parental education and child physical activity in lower economic status countries. Relationships between maternal and paternal education

  12. Stellar activity cycles and asteroseismology

    NASA Astrophysics Data System (ADS)

    Salabert, D.

    2011-12-01

    The success of helioseismology is due to its capability to accurately measure the p-mode parameters of the solar eigenmode spectrum, which allow us to infer unique information about the internal structure and dynamics of the Sun from its surface all the way down to the core. It has contributed greatly to a clearer understanding of the Sun and provided insights into the complex solar magnetism, by means for instance of the variability of the characteristics of the p-mode spectrum. Indeed, variations in the mean strength of the solar magnetic field lead to significant shifts in the frequencies of even the lowest-degree p modes with high levels of correlation with solar surface activity proxies. These frequency shifts are explained to arise from structural changes in the outer layers of the Sun during the 11-year activity cycle, which is understood to be driven by a dynamo process. However, clear differences between p-mode frequencies and solar surface activity during the unusually extended minimum of cycle 23 were observed. The origin of the p-mode variability is thus far from being properly understood and a better comprehension of its relationship with solar and stellar activity cycles will help us in our understanding of the dynamo processes. Spectroscopic measurements of Ca H and K emission lines revealed magnetic activity variations in a large sample of solar-type stars with timescales ranging from 2.5 and 25 years. This broad range of cycle periods is thought to reflect differences in the rotational properties and the depths of the surface convection zones with various masses and ages. However, spectroscopic measurements are only good proxies of surface magnetic fields. The recent discovery of variations with magnetic activity in the p-mode oscillation frequencies of the solar-like star HD 49933 observed by CoRoT, with a frequency dependence comparable in shape to the one observed in the Sun, opens a new era in the study of the physical phenomena involved in the

  13. Vitamin D status is associated with cardiometabolic markers in 8-11-year-old children, independently of body fat and physical activity.

    PubMed

    Petersen, Rikke A; Dalskov, Stine-Mathilde; Sørensen, Louise B; Hjorth, Mads F; Andersen, Rikke; Tetens, Inge; Krarup, Henrik; Ritz, Christian; Astrup, Arne; Michaelsen, Kim F; Mølgaard, Christian; Damsgaard, Camilla T

    2015-11-28

    Vitamin D status has been associated with cardiometabolic markers even in children, but the associations may be confounded by fat mass and physical activity behaviour. This study investigated associations between vitamin D status and cardiometabolic risk profile, as well as the impact of fat mass and physical activity in Danish 8-11-year-old children, using baseline data from 782 children participating in the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study. We assessed vitamin D status as serum 25-hydroxyvitamin D (25(OH)D) and measured blood pressure, fasting plasma glucose, homoeostasis model of assessment-insulin resistance, plasma lipids, inflammatory markers, anthropometry and fat mass by dual-energy X-ray absorptiometry, and physical activity by 7 d accelerometry during August-November. Mean serum 25(OH)D was 60·8 (sd 18·7) nmol/l. Each 10 mmol/l 25(OH)D increase was associated with lower diastolic blood pressure (-0·3 mmHg, 95 % CI -0·6, -0·0) (P=0·02), total cholesterol (-0·07 mmol/l, 95 % CI -0·10, -0·05), LDL-cholesterol (-0·05 mmol/l, 95 % CI -0·08, -0·03), TAG (-0·02 mmol/l, 95 % CI -0·03, -0·01) (P≤0·001 for all lipids) and lower metabolic syndrome (MetS) score (P=0·01). Adjustment for fat mass index did not change the associations, but the association with blood pressure became borderline significant after adjustment for physical activity (P=0·06). In conclusion, vitamin D status was negatively associated with blood pressure, plasma lipids and a MetS score in Danish school children with low prevalence of vitamin D deficiency, and apart from blood pressure the associations were independent of body fat and physical activity. The potential underlying cause-effect relationship and possible long-term implications should be investigated in randomised controlled trials. PMID:26382732

  14. Solar activity secular cycles

    NASA Astrophysics Data System (ADS)

    Kramynin, A. P.; Mordvinov, A. V.

    2013-12-01

    Long-term variations in solar activity secular cycles have been studied using a method for the expansion of reconstructed sunspot number series Sn( t) for 11400 years in terms of natural orthogonal functions. It has been established that three expansion components describe more than 98% of all Sn( t) variations. In this case, the contribution of the first expansion component is about 92%. The averaged form of the 88year secular cycle has been determined based on the form of the first expansion coordinate function. The quasi-periodicities modulating the secular cycle have been revealed based on the time function conjugate to the first function. The quasi-periodicities modulating the secular cycle coincide with those observed in the Sn( t) series spectrum. A change in the secular cycle form and the time variations in this form are described by the second and third expansion components, the contributions of which are about 4 and 2%, respectively. The variations in the steepness of the secular cycle branches are more pronounced in the 200-year cycle, and the secular cycle amplitude varies more evidently in the 2300-year cycle.

  15. Coupling of the Matched Gravity and Electromagnetic Fields of the Sun with Jupiter and its Moons Together in Nearest Portion of Jupiter's Orbit to the Sun as the Main Cause of the Peak of Approximately 11 Yearly Solar Cycles and Hazards from Solar Storms

    NASA Astrophysics Data System (ADS)

    Gholibeigian, Kazem; Gholibeigian, Hassan

    2016-04-01

    strongest variable GEFs in solar system after the Sun. For example, Ganymede is the largest moon of Jupiter and in the Solar System. Completing an orbit in roughly seven days. It means that it generates 52 GEFs oscillations (loading, unloading) per year in solar cycle while it is rotating around the Jupiter. New observations of the planet's extreme ultraviolet emissions show that bright explosions of Jupiter's aurora by the planet-moon interaction, not by solar activity [Tomoki Kimura, JAEA]. Coupling of Jupiter's GEFs and its moons with the Sun generate very strong GEFs and approximately 11 yearly solar cycles. The peaks of each cycle is when the Jupiter passes from the nearest portion of its orbit to the Sun. which some of its peaks generate gigantic solar storms and hazards to the Earth. The Earth passes from between of Sun and Jupiter eleven times in each solar cycle and may be under shooting of storms from the both side specially during 2-3 years in cycle's peak.

  16. Influenza pandemics, solar activity cycles, and vitamin D.

    PubMed

    Hayes, Daniel P

    2010-05-01

    There is historic evidence that influenza pandemics are associated with solar activity cycles (the Schwabe-cycle of about 11-years periodicity). The hypothesis is presented and developed that influenza pandemics are associated with solar control of vitamin D levels in humans which waxes and wanes in concert with solar cycle dependent ultraviolet radiation. It is proposed that this solar cycle dependence arises both directly from cyclic control of the amount of ultraviolet radiation as well as indirectly through cyclic control of atmospheric circulation and dynamics. PMID:20056531

  17. Activity Cycles in Stars

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.

    2009-01-01

    Starspots and stellar activity can be detected in other stars using high precision photometric and spectrometric measurements. These observations have provided some surprises (starspots at the poles - sunspots are rarely seen poleward of 40 degrees) but more importantly they reveal behaviors that constrain our models of solar-stellar magnetic dynamos. The observations reveal variations in cycle characteristics that depend upon the stellar structure, convection zone dynamics, and rotation rate. In general, the more rapidly rotating stars are more active. However, for stars like the Sun, some are found to be inactive while nearly identical stars are found to be very active indicating that periods like the Sun's Maunder Minimum (an inactive period from 1645 to 1715) are characteristic of Sun-like stars.

  18. The Heliosphere Through the Solar Activity Cycle

    NASA Technical Reports Server (NTRS)

    Balogh, A.; Lanzerotti, L. J.; Suess, S. T.

    2006-01-01

    Understanding how the Sun changes though its 11-year sunspot cycle and how these changes affect the vast space around the Sun the heliosphere has been one of the principal objectives of space research since the advent of the space age. This book presents the evolution of the heliosphere through an entire solar activity cycle. The last solar cycle (cycle 23) has been the best observed from both the Earth and from a fleet of spacecraft. Of these, the joint ESA-NASA Ulysses probe has provided continuous observations of the state of the heliosphere since 1990 from a unique vantage point, that of a nearly polar orbit around the Sun. Ulysses results affect our understanding of the heliosphere from the interior of the Sun to the interstellar medium - beyond the outer boundary of the heliosphere. Written by scientists closely associated with the Ulysses mission, the book describes and explains the many different aspects of changes in the heliosphere in response to solar activity. In particular, the authors describe the rise in solar ESA and NASA have now unamiously agreed a third extension to operate the highly successful Ulysses spacecraft until March 2008 and, in 2007 and 2008, the European-built space probe will fly over the poles of the Sun for a third time. This will enable Ulysses to add an important chapter to its survey of the high-latitude heliosphere and this additional material would be included in a 2nd edition of this book.

  19. Changes in Commitment to Physical Activity among 8-to-11-Year-Old Girls Participating in a Curriculum-Based Running Program

    ERIC Educational Resources Information Center

    DeBate, Rita; Zhang, Yan; Thompson, Sharon H.

    2007-01-01

    Background: Despite findings that support physical activity (PA) as an effective means of improving health and quality of life, PA levels among girls tend to decline with age. Purpose: The purpose of this study was to assess changes pertaining to PA commitment following a curriculum-based running program designed for 3rd-to-5th-grade girls.…

  20. Properties of stellar activity cycles

    NASA Astrophysics Data System (ADS)

    Korhonen, Heidi

    2015-08-01

    The current photometric datasets, that span decades, allow for studying long-term magentic cycles on active stars. Complementary Ca H&K observations give information also on the cycles of normal solar-like stars, which have significantly smaller, and less easily detectable, spots. In recent years, high precision space-based observations, for example from the Kepler satellite, have allowed also to study the sunspot-like spot sizes in other stars. In this talk I will review what is known about the properties of the cyclic stellar activity in other stars than our Sun, and also discuss the future prospects in this field.

  1. Activity cycles of M dwarfs

    NASA Astrophysics Data System (ADS)

    Savanov, I. S.

    2012-09-01

    We have determined activity cycles for coolest M dwarfs using photometry from the ASAS survey. The time scales of brightness variations were determined for the program stars using calculated amplitude power spectra and wavelet spectra. Most of ther program stars display periodicities in their light-curve variations, with periods from hundreds of days to years. Analysis of diagrams plotting P cyc/ P rot versus 1/ P rot in logarithmic coordinates shows that the data for all our program objects fit the general relation quite well. No differences in the activity cycles are found for our sample stars, which have different masses and thus internal structures, some having convective envelopes and others being totally convective. Our analysis indicates that the slope i of this relation is close to unity, regardless of whether it is determined from all data, from data for the shortest cycles, or from data for the longest cycles. This value of i differs from values in the literature for stars of other spectral types. Our analysis of the P cyc- P rot relation indicates that the activity cycles for the studied sample of M dwarfs do not depend on the rotation periods of these objects. The data for the studied objects do not agree with any of the relations for relatively young (active) stars or older (less active) stars. The studied M dwarfs probably form another branch of low-mass stars that display more random, irregular magnetic activity on their surfaces, which is generated and supported by the distributed dynamo mechanism or a small-scale dynamo mechanism.

  2. Analysis of variability of p-mode parameters in 11 years of IRIS data

    NASA Astrophysics Data System (ADS)

    Salabert, D.; Jiménez-Reyes, S. J.; Fossat, E.; Cacciani, A.; Ehgamberdiev, S.; Gelly, B.; Grec, G.; Hoeksema, J. T.; Khalikov, S.; Lazrek, M.; Pallé, P.; Schmider, F. X.; Tomczyk, S.

    2002-03-01

    11 years of IRIS (the low degree helioseismology network) have been analysed for the study of p-modes parameters variability. The duty cycle of the network data has been improved by the partial gap filling method named "repetitive music". This paper discusses the variations of all p-modes parameters along these 11 years.

  3. Trends in solar UV and EUV irradiance: An update to the MgII Index and a comparison of proxies and data to evaluate trends of the last 11-year solar cycle

    NASA Astrophysics Data System (ADS)

    Viereck, R. A.; Snow, M.; Deland, M. T.; Weber, M.; Puga, L.; Bouwer, D.

    2010-12-01

    Long records of solar spectral irradiance are quite rare and differentiating between solar variability and instrumental changes can be a challenge. Proxies for solar irradiance have provided independent measures of solar variability and can be used to extend the data record beyond the observation period and to help differentiate solar variability from instrument drifts. Recently however there are indications that the relationships, that have remained relatively constant over the last several solar cycles, have changed significantly during this recent cycle. There are increasing divergences between the proxies and the observed irradiances. This divergence may indicate a fundamental change in the sun itself. We will present an update to the MgII composite index which is used a proxy for solar EUV, UV, and total irradiances. We will examine this recent solar minimum period and compare the MgII and other proxies to each other and to the EUV, UV, and TSI in an effort to better understand the past, present, and future solar spectral irradiance records.

  4. Unusual Migration of Prominence Activities in the Southern Hemisphere during Cycles 23-24

    NASA Astrophysics Data System (ADS)

    Shimojo, Masumi

    2013-12-01

    The solar activity in Cycles 23-24 shows differences from the previous cycles that were observed with modern instruments, e.g., long cycle duration and a small number of sunspots. To appreciate the anomalies further, we investigated the prominence eruptions and disappearances observed with the Nobeyama Radioheliograph for over 20 years. Consequently, we found that the occurrence of prominence activities in the northern hemisphere is normal because the period of the number variation is 11 years, and the migration of the producing region of the prominence activities traces the migration of 11 years ago. On the other hand, the migration in the southern hemisphere significantly differs from that in the northern hemisphere and the previous cycles. The prominence activities occurred over -50° latitude in spite of the late decay phase of Cycle 23, and the number of prominence activities in the higher latitude region (over -65°) is very small, even near the solar maximum of Cycle 24. The results suggest that the anomalies of the global magnetic field distribution started at the solar maximum of Cycle 23. A comparison of the butterfly diagram of the prominence activities with the magnetic butterfly diagram indicates that the timing of "the rush to the pole" and the polar magnetic field closely relates to unusual migration. Considering that the rush to the pole is made of the sunspots, the hemispheric asymmetry of the sunspots and the strength of the polar magnetic fields are essential for understanding the anomalies of the prominence activities.

  5. The 11-year solar cycle continues during prolonged sunspot minima

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2012-12-01

    Streaming into the solar system at nearly the speed of light, galactic cosmic rays (GCRs) are a high-energy mix of protons, electrons, and atomic nuclei. As they pass into reach of the outflowing solar wind, the propagation of GCRs is inhibited. Galactic cosmic rays that make it to Earth interact with the atmosphere, creating a shower of heavy isotopes including beryllium-10. Beryllium-10 isotope concentrations recorded in ice cores provide a long-term, high temporal resolution record of galactic cosmic ray flux.

  6. The Hydrologic Cycle Distributed Active Archive Center

    NASA Technical Reports Server (NTRS)

    Hardin, Danny M.; Goodman, H. Michael

    1995-01-01

    The Marshall Space Flight Center Distributed Active Archive Center in Huntsville, Alabama supports the acquisition, production, archival and dissemination of data relevant to the study of the global hydrologic cycle. This paper describes the Hydrologic Cycle DAAC, surveys its principle data holdings, addresses future growth, and gives information for accessing the data sets.

  7. Borderline phylloides tumor in an 11-year-old girl.

    PubMed

    Selamzade, M; Gidener, C; Koyuncuoglu, M; Mevsim, A

    1999-07-01

    Phylloides tumor is an uncommon breast tumor in children. Only a few cases have been reported in the literature. A case of borderline phylloides tumor in an 11-year-old girl is described. PMID:10415310

  8. A possible activity cycle in Proxima Centauri

    NASA Astrophysics Data System (ADS)

    Cincunegui, C.; Díaz, R. F.; Mauas, P. J. D.

    2007-01-01

    Context: Several late-type stars present activity cycles resembling the Solar one. This fact has been observed mostly in stars ranging from F to K, i.e., in stars with a radiative core and an outer convective layer. Aims: This work aims at studying whether an activity cycle can be detected in the dM5.5e star Proxima Centauri, which is supposed to be completely convective. Methods: We present periodical medium-resolution echelle observations covering the complete visual range, which were taken at the CASLEO Argentinean Observatory. These observations are distributed over 7 years. We discarded the spectra that present flare activity, and analyze the remaining activity levels using four different statistical techniques to look for a period of activity. Results: We find strong evidence of a cyclic activity, with a period of ~442 days. We also estimate that the Ca ~II S index varies around 130% due to activity variations outside of flares.

  9. A possible activity cycle in Proxima Centauri

    NASA Astrophysics Data System (ADS)

    Cincunegui, C.; Díaz, R. F.; Mauas, P. J. D.

    Several late-type stars (stars with a radiative core and an outer convective layer) present activity cycles resembling the Solar one. This work aims at studying whether an activity cycle can be detected in the dM5.5e star Proxima Centauri, which is supposed to be completely convective. We present periodical medium-resolution echelle observations covering the complete visual range, which were taken at the CASLEO Argentinean Observatory. These observations are distributed along 7 years. We analize the activity levels to look for a period of activity. We find strong evidence of a cyclic activity, with a period of ˜442 days. We also estimated that the Ca II S index varies around 130% due to activity variations outside of flares.

  10. Global water cycle and solar activity variations

    NASA Astrophysics Data System (ADS)

    Al-Tameemi, Muthanna A.; Chukin, Vladimir V.

    2016-05-01

    The water cycle is the most active and most important component in the circulation of global mass and energy in the Earth system. Furthermore, water cycle parameters such as evaporation, precipitation, and precipitable water vapour play a major role in global climate change. In this work, we attempt to determine the impact of solar activity on the global water cycle by analyzing the global monthly values of precipitable water vapour, precipitation, and the Solar Modulation Potential in 1983-2008. The first object of this study was to calculate global evaporation for the period 1983-2008. For this purpose, we determined the water cycle rate from satellite data, and precipitation/evaporation relationship from 10 years of Planet Simulator model data. The second object of our study was to investigate the relationship between the Solar Modulation Potential (solar activity index) and the evaporation for the period 1983-2008. The results showed that there is a relationship between the solar modulation potential and the evaporation values for the period of study. Therefore, we can assume that the solar activity has an impact on the global water cycle.

  11. How active was solar cycle 22?

    NASA Technical Reports Server (NTRS)

    Hoegy, W. R.; Pesnell, W. D.; Woods, T. N.; Rottman, G. J.

    1993-01-01

    Solar EUV observations from the Langmuir probe on Pioneer Venus Orbiter suggest that at EUV wavelengths solar cycle 22 was more active than solar cycle 21. The Langmuir probe, acting as a photodiode, measured the integrated solar EUV flux over a 13 1/2 year period from January 1979 to June 1992, the longest continuous solar EUV measurement. The Ipe EUV flux correlated very well with the SME measurement of L-alpha during the lifetime of SME and with the UARS SOLSTICE L-alpha from October 1991 to June 1992 when the Ipe measurement ceased. Starting with the peak of solar cycle 21, there was good general agreement of Ipe EUV with the 10.7 cm, Ca K, and He 10830 solar indices, until the onset of solar cycle 22. From 1989 to the start of 1992, the 10.7 cm flux exhibited a broad maximum consisting of two peaks of nearly equal magnitude, whereas Ipe EUV exhibited a strong increase during this time period making the second peak significantly higher than the first. The only solar index that exhibits the same increase in solar activity as Ipe EUV and L-alpha during the cycle 22 peak is the total magnetic flux. The case for high activity during this peak is also supported by the presence of very high solar flare intensity.

  12. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    SciTech Connect

    Buccino, Andrea P.; Petrucci, Romina; Mauas, Pablo J. D.; Jofré, Emiliano

    2014-01-20

    AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R{sub D}{sup ′}), Hα, and Ca II K fluxes at different activity levels of AD Leo, including flares.

  13. Conservative Management of Cardiac Hemangioma for 11 Years.

    PubMed

    Gribaa, Rym; Slim, Mehdi; Neffati, Elyes; Boughzela, Essia

    2015-10-01

    Cardiac hemangiomas are benign tumors with an unpredictable natural history. Surgical resection is the treatment of choice; however, conservative management can be an alternative in some patients. We report a case of a left-sided cardiac hemangioma that we managed conservatively for 11 years without obvious major complications in the patient, an adult woman. PMID:26504439

  14. Conservative Management of Cardiac Hemangioma for 11 Years

    PubMed Central

    Slim, Mehdi; Neffati, Elyes; Boughzela, Essia

    2015-01-01

    Cardiac hemangiomas are benign tumors with an unpredictable natural history. Surgical resection is the treatment of choice; however, conservative management can be an alternative in some patients. We report a case of a left-sided cardiac hemangioma that we managed conservatively for 11 years without obvious major complications in the patient, an adult woman. PMID:26504439

  15. The 11-year solar radiation rhythm and the North Atlantic Oscillation during the last two centuries

    NASA Astrophysics Data System (ADS)

    Brunck, Heiko; Sirocko, Frank

    2016-04-01

    The study is based on a historical chronology of freezing events in central Europe during the last 230 years (river Rhine (Sirocko et al. 2012), Baltic Sea (Koslowski and Glaser, 1999) and Lake Constance (Dobras, 1983)). These regions display both significant similarities with extremely cold winters in central Germany for the years 1799, 1830, 1895, 1929, 1940, 1942, 1947, 1956 and 1963, as well as regional differences in timing and severity of cold winters. The statistical analysis of all 92 historical freezing events showed that 80 events occurred during a negative NAOwinter phase. The bootstrap test defined the results as extremely significant. To understand the climatic forcing behind the freezing chronology the NAO data set was smoothed by a three point running mean filter and compared with the 11- year cyclicity of the sunspot numbers. A complete NAO cycle can be observed within each solar cycle back to 1960 and from 1820 to 1900. From 1900 to 1960 the correlation between the Sun and NAO was weak. This on/off mode becomes visible only in the smoothed NAO data, when time intervals longer than "normal" weather observations are analysed. Statistical test for the coherence of the entire 230 years are insignificant. However, the relation is highly significant, if only the intervals from 1960 to 2010 and 1830 to 1900 are analysed. The phase correlation can be explained by temperature variations up to +-2.5°C in time series of stratospheric air temperature at 40 km height, where ozone is formed by ultraviolet solar radiation. Advanced analysis of sea surface temperatures from reanalysis data (ECMWF Data Archiv, 2013) between 30° - 40°N and 65° - 75°N indicate similar temperature variations in phase with the solar activity. Consequently, the 11 year solar periodicity is related to various parts of the Earth/Ocean/Atmosphere system and not only to the stratospheric signal. However, the NAO is the dominating mediator to implement a solar component into the

  16. Recent Advances in GEO Water Cycle Activities

    NASA Astrophysics Data System (ADS)

    Lawford, R. G.

    2009-12-01

    Over the past few years GEO (Group on Earth Observations) efforts within the Water Societal Benefit Area (SBA) have been coordinated by the Science Committee of the former Integrated Global Observing Strategy Partnership (IGOS-P) IGWCO (Integrated Global Water Cycle Observations) theme. Within this framework a number of projects related to data system design, product development, and capacity building are being carried out. GEO has recently consolidated the Water SBA activities into three tasks, namely Droughts, Floods and Water Resource Management; Capacity Building for Water Resource Management (in Asia, Africa and the Americas); and Integrated Products for Water Resource Management and Research. In order to strengthen interactions with the GEO and its User Interface Committee, a Water Cycle Community of Practice (COP) was initiated. In addition, within the past year, the IGWCO Science Committee has decided to also function as a Community of Practice in collaboration with the existing Water Cycle COP. This overview will provide background and an update on the GEO Water SBA activities with an emphasis of the way in which these activities are being integrated within the three tasks. It will also describe activities that are planned for 2010 to facilitate this integration. Recent advances related to drought monitoring, capacity and network building, and observational and data systems will be highlighted. New water-related activities arising from collaborations between US GEO and Canada GEO, and through activities within the GEO Architecture and Data Committee, will also be described. This presentation will conclude with a longer-term outlook for water within the GEO framework and provide some guidance for interested experts on how they can become involved in helping to implement these plans.

  17. Stochastic cycle selection in active flow networks.

    PubMed

    Woodhouse, Francis G; Forrow, Aden; Fawcett, Joanna B; Dunkel, Jörn

    2016-07-19

    Active biological flow networks pervade nature and span a wide range of scales, from arterial blood vessels and bronchial mucus transport in humans to bacterial flow through porous media or plasmodial shuttle streaming in slime molds. Despite their ubiquity, little is known about the self-organization principles that govern flow statistics in such nonequilibrium networks. Here we connect concepts from lattice field theory, graph theory, and transition rate theory to understand how topology controls dynamics in a generic model for actively driven flow on a network. Our combined theoretical and numerical analysis identifies symmetry-based rules that make it possible to classify and predict the selection statistics of complex flow cycles from the network topology. The conceptual framework developed here is applicable to a broad class of biological and nonbiological far-from-equilibrium networks, including actively controlled information flows, and establishes a correspondence between active flow networks and generalized ice-type models. PMID:27382186

  18. GEO Water Cycle Activities and Plans

    NASA Astrophysics Data System (ADS)

    Lawford, R.; Koike, T.; Ishida, C.; Grabs, W.

    2008-12-01

    The Group on Earth Observations (GEO) consists of more than 70 countries and 40 international organizations which are working together to develop the Global Earth Observation System of Systems (GEOSS). Since its launch in 2004, GEO has stimulated a wide range of activities related to data systems and their architecture, the development of science and technology to support observational programs, user interactions and interfaces, and capacity building. GEO tasks directed at Water Resources Management, one of the nine GEO Societal Benefit areas, are an integral part of these developments. They draw heavily upon the activities of the Integrated Global Water Cycle Observations (IGWCO) theme and on the activities and infrastructure provided through GEO and its committees. Within the GEO framework the water related activities have been focused on four specific tasks namely integrated data set development; information for floods, droughts and water management; water quality, and capacity building. Currently these efforts are being facilitated by the IGWCO theme that was formed under the former Integrated Global Observing Strategy Partnership (IGOS-P). With the dissolution of this partnership, other mechanisms, including the GEO Water Cycle Community of Practice, are being considered as new opportunitites for coordinating the work of the theme and the water-related GEO tasks. This talk provides a description of the GEO water tasks and reviews the progress that has been made in addressing them. It also provides a perspective on new opportunities and briefly describes some of the mechanisms, such as the Water Cycle Community of Practice, that could be expanded to coordinate a more comprehensive set of water tasks and greater community involvement.

  19. A Comparison Between Global Proxies of the Sun's Magnetic Activity Cycle: Inferences from Helioseismology

    NASA Astrophysics Data System (ADS)

    Broomhall, A.-M.; Nakariakov, V. M.

    2015-11-01

    The last solar minimum was, by recent standards, unusually deep and long. We are now close to the maximum of the subsequent solar cycle, which is relatively weak. In this article we make comparisons between different global (unresolved) measures of the Sun's magnetic activity to investigate how they are responding to this weak-activity epoch. We focus on helioseismic data, which are sensitive to conditions, including the characteristics of the magnetic field, in the solar interior. Also considered are measures of the magnetic field in the photosphere (sunspot number and sunspot area), the chromosphere and corona (10.7 cm radio flux and 530.3 nm green coronal index), and two measures of the Sun's magnetic activity closer to Earth (the interplanetary magnetic field and the galactic cosmic-ray intensity). Scaled versions of the activity proxies diverge from the helioseismic data around 2000, indicating a change in relationship between the proxies. The degree of divergence varies from proxy to proxy, with sunspot area and 10.7 cm flux showing only small deviations, while sunspot number, coronal index, and the two interplanetary proxies show much larger departures. In Cycle 24 the deviations in the solar proxies and the helioseismic data decrease, raising the possibility that the deviations observed in Cycle 23 are just symptomatic of a 22-year Hale cycle. However, the deviations in the helioseismic data and the interplanetary proxies increase in Cycle 24. Interestingly, the divergence in the solar proxies and the helioseismic data are not reflected in the shorter-term variations (often referred to as quasi-biennial oscillations) observed on top of the dominant 11-year solar cycle. However, despite being highly correlated in Cycle 22, the short-term variations in the interplanetary proxies show very little correlation with the helioseismic data during Cycles 23 and 24.

  20. Geomagnetic activity during 10 - 11 solar cycles that has been observed by old Russian observatories.

    NASA Astrophysics Data System (ADS)

    Seredyn, Tomasz; Wysokinski, Arkadiusz; Kobylinski, Zbigniew; Bialy, Jerzy

    2016-07-01

    A good knowledge of solar-terrestrial relations during past solar activity cycles could give the appropriate tools for a correct space weather forecast. The paper focuses on the analysis of the historical collections of the ground based magnetic observations and their operational indices from the period of two sunspot solar cycles 10 - 11, period 1856 - 1878 (Bartels rotations 324 - 635). We use hourly observations of H and D geomagnetic field components registered at Russian stations: St. Petersburg - Pavlovsk, Barnaul, Ekaterinburg, Nertshinsk, Sitka, and compare them to the data obtained from the Helsinki observatory. We compare directly these records and also calculated from the data of the every above mentioned station IHV indices introduced by Svalgaard (2003), which have been used for further comparisons in epochs of assumed different polarity of the heliospheric magnetic field. We used also local index C9 derived by Zosimovich (1981) from St. Petersburg - Pavlovsk data. Solar activity is represented by sunspot numbers. The correlative and continuous wavelet analyses are applied for estimation of the correctness of records from different magnetic stations. We have specially regard to magnetic storms in the investigated period and the special Carrington event of 1-2 Sep 1859. Generally studied magnetic time series correctly show variability of the geomagnetic activity. Geomagnetic activity presents some delay in relation to solar one as it is seen especially during descending and minimum phase of the even 11-year cycle. This pattern looks similarly in the case of 16 - 17 solar cycles.

  1. Coronal Activity and Extended Solar Cycles

    NASA Astrophysics Data System (ADS)

    Altrock, R. C.

    2012-12-01

    Wilson et al. (1988, Nature 333, 748) discussed a number of solar parameters, which appear at high latitudes and gradually migrate towards the equator, merging with the sunspot "butterfly diagram". They found that this concept had been identified by earlier investigators extending back to 1957. They named this process the "Extended Solar Cycle" (ESC). Altrock (1997, Solar Phys. 170, 411) found that this process continued in Fe XIV 530.3 nm emission features. In cycles 21 - 23 solar maximum occurred when the number of Fe XIV emission regions per day > 0.19 (averaged over 365 days and both hemispheres) first reached latitudes 18°, 21° and 21°, for an average of 20° ± 1.7°. Other recent studies have shown that Torsional Oscillation (TO) negative-shear zones are co-located with the ESC from at least 50° down to the equator and also in the zones where the Rush to the Poles occur. These phenomena indicate that coronal activity occurring up to 50° and higher latitudes is related to TO shear zones, another indicator that the ESC is an important solar process. Another high-latitude process, which appears to be connected with the ESC, is the "Rush to the Poles" ("Rush") of polar crown prominences and their associated coronal emission, including Fe XIV. The Rush is is a harbinger of solar maximum (cf. Altrock, 2003, Solar Phys. 216, 343). Solar maximum in cycles 21 - 23 occurred when the center line of the Rush reached a critical latitude. These latitudes were 76°, 74° and 78°, respectively, for an average of 76° ± 2°. Applying the above conclusions to Cycle 24 is difficult due to the unusual nature of this cycle. Cycle 24 displays an intermittent "Rush" that is only well-defined in the northern hemisphere. In 2009 an initial slope of 4.6°/yr was found in the north, compared to an average of 9.4 ± 1.7 °/yr in the previous three cycles. This early fit to the Rush would have reached 76° at 2014.6. However, in 2010 the slope increased to 7.5°/yr (an increase

  2. Flip-flop cycles in solar and stellar activity

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.

    2006-08-01

    Doppler images and long time series of photometric observations of cool active stars reveal permanent active longitudes on their surfaces. They are found to alternate their dominant activity quasi-periodically which indicates a new type of the activity cycles, flip-flop cycles. In this talk I will review properties of active longitudes and flip-flop cycles on different types of active stars including the Sun.

  3. Activity Cycles in the Hyades and Praesepe

    NASA Astrophysics Data System (ADS)

    Baliunas, Sallie L.

    The giant stars in the Hyades present a well-studied group of stars of spectral type KO III. Their optical properties are quite similar, if not identical. All rotate with the same, slow period. Yet their chromospheric and coronal emission is different one from another, by as much as a factor of ten. We conjecture that this disparity results from sampling during different phases of long-term activity cycles which are present among dwarf stars. Some variation on a three-year timescale has been observed, as well as during phases of rotation modulation, however, at levels too small to explain the discrepancy of the emission strengths between the stars. We propose to investigate the range of chromospheric activity from these giants which are similar in the visible three ways: (a) reobserve the Hyades to search for variability on at least a seven-year timescale; (b) reobserve another young cluster, Praesepe, with four KO III stars similar to those in the Hyades to search for variability on a five-year timescale; (c) extend the sampling to four Hyades moving group stars with similar photospheric properties. The ultraviolet spectra provided by IUE represent the longest time frame, seven years, over which to search for long-term activity variations.

  4. A decrease in solar and geomagnetic activity from cycle 19 to cycle 24

    NASA Astrophysics Data System (ADS)

    Gvishiani, A. D.; Starostenko, V. I.; Sumaruk, Yu. P.; Soloviev, A. A.; Legostaeva, O. V.

    2015-05-01

    Variations in the solar and geomagnetic activity from cycle 19 to cycle 24 were considered based on data from the magnetic observatories of the Russian-Ukrainian INTERMAGNET segment and international centers of data on solar-terrestrial physics. It has been indicated that activity decreases over the course of time. This is especially evident during the cycle 24 growth phase. The possible causes and consequences of a decrease in geomagnetic activity were analyzed.

  5. A prediction of geomagnetic activity for solar cycle 23

    NASA Astrophysics Data System (ADS)

    Cliver, E. W.; Ling, A. G.; Wise, J. E.; Lanzerotti, L. J.

    1999-04-01

    Using a database of 13 solar cycles of geomagnetic aa data, we obtained correlations between cycle averages of geomagnetic activity (and sunspot number) and the numbers of days with disturbance levels above certain aa thresholds. We then used a precursor-type relation to predict an average aa index of 23.1 nT for cycle 23 and inserted this average aa value into the above correlations to forecast the integral size distribution of geomagnetic activity for the new cycle. The predicted size distribution is similar to that observed for cycles 21 and 22 but most closely resembles that of solar cycle 18 (1944-1954), which was slightly smaller than cycles 21 and 22. Our prediction agrees reasonably well with the ``climatology-based'' forecast made by the intergovernmental panel tasked to predict geomagnetic activity for the coming solar cycle and is significantly different from their ``precursor-based'' prediction.

  6. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.; Upton, Lisa

    2013-01-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow can modulate the amplitude of the following sunspot cycle through its influence on the Sun's polar fields.

  7. Carotid Artery Stenting: Single-Center Experience Over 11 Years

    SciTech Connect

    Nolz, Richard Schernthaner, Ruediger Egbert; Cejna, Manfred; Schernthaner, Melanie Lammer, Johannes Schoder, Maria

    2010-04-15

    This article reports the results of carotid artery stenting during an 11-year period. Data from 168 carotid artery stenting procedures (symptomatic, n = 55; asymptomatic, n = 101; symptoms not accessible, n = 12) were retrospectively collected. Primary technical success rate, neurological events in-hospital, access-site complications, and contrast-induced nephropathy (n = 118) were evaluated. To evaluate the influence of experience in carotid artery stenting on intraprocedural neurologic complications, patients were divided into two groups. Group 1 included the first 80 treated patients, and group 2 the remainder of the patients (n = 88). In-stent restenoses at last-follow-up examinations (n = 89) were assessed. The overall primary technical success rate was 95.8%. The in-hospital stroke-death rate was 3.0% (n = 5; symptomatic, 5.4%; asymptomatic, 2.0%; p = 0.346). Neurologic complications were markedly higher in group 1 (4.2%; three major strokes; symptomatic, 2.8%, asymptomatic, 1.4%) compared to group 2 (2.4%; one major and one minor stroke-symptomatic, 1.2%, asymptomatic 1.2%), but this was not statistically significant. Further complications were access-site complications in 12 (7.1%), with surgical revision required in 1 (0.6%) and mild contrast-induced nephropathy in 1 (0.85%). Twenty-one (23.6%) patients had >50% in-stent restenosis during a mean follow-up of 28.2 months. In conclusion, advanced experience in carotid artery stenting leads to an acceptable periprocedural stroke-death rate. In-stent restenosis could be a critical factor during the follow-up course.

  8. Rest-Activity Cycles in Childhood and Adolescent Depression.

    ERIC Educational Resources Information Center

    Armitage, Roseanne; Hoffmann, Robert; Emslie, Graham; Rintelman, Jeanne; Moore, Jarrette; Lewis, Kelly

    2004-01-01

    Objective: To quantify circadian rhythms in rest-activity cycles in depressed children and adolescents. Method: Restactivity cycles were evaluated by actigraphy over five consecutive 24-hour periods in 100 children and adolescents, including 59 outpatients with major depressive disorder (MDD) and 41 healthy normal controls. Total activity, total…

  9. A 12-year Activity Cycle for the Nearby Planet Host Star HD 219134

    NASA Astrophysics Data System (ADS)

    Johnson, Marshall C.; Endl, Michael; Cochran, William D.; Meschiari, Stefano; Robertson, Paul; MacQueen, Phillip J.; Brugamyer, Erik J.; Caldwell, Caroline; Hatzes, Artie P.; Ramírez, Ivan; Wittenmyer, Robert A.

    2016-04-01

    The nearby (6.5 pc) star HD 219134 was recently shown by Motalebi et al. and Vogt et al. to host several planets, the innermost of which is transiting. We present 27 years of radial velocity (RV) observations of this star from the McDonald Observatory Planet Search program, and 19 years of stellar activity data. We detect a long-period activity cycle measured in the Ca ii SHK index, with a period of 4230 ± 100 days (11.7 years), very similar to the 11 year solar activity cycle. Although the period of the Saturn-mass planet HD 219134 h is close to half that of the activity cycle, we argue that it is not an artifact due to stellar activity. We also find a significant periodicity in the SHK data due to stellar rotation with a period of 22.8 days. This is identical to the period of planet f identified by Vogt et al., suggesting that this RV signal might be caused by rotational modulation of stellar activity rather than a planet. Analysis of our RVs allows us to detect the long-period planet HD 219134 h and the transiting super-Earth HD 219134 b. Finally, we use our long time baseline to constrain the presence of longer period planets in the system, excluding to 1σ objects with M{sin}i\\gt 0.36{M}J at 12 years (corresponding to the orbital period of Jupiter) and M{sin}i\\gt 0.72{M}J at a period of 16.4 years (assuming a circular orbit for an outer companion).

  10. Geomagnetic Activity Indicates Large Amplitude for Sunspot Cycle 24

    NASA Technical Reports Server (NTRS)

    Hathaway, D. H.; Wilson, R. M.

    2006-01-01

    The level of geomagnetic activity near the time of solar activity minimum has been shown to be a reliable indicator for the amplitude of the following solar activity maximum. The geomagnetic activity index aa can be split into two components: one associated with solar flares, prominence eruptions, and coronal mass ejections which follows the solar activity cycle and a second component associated with recurrent high speed solar wind streams which is out of phase with the solar activity cycle. This second component often peaks before solar activity minimum and has been one of the most reliable indicators for the amplitude of the following maximum. The size of the recent maximum in this second component indicates that solar activity cycle 24 will be much higher than average - similar in size to cycles 21 and 22.

  11. Inferences on Stellar Activity and Stellar Cycles from Asteroseismology

    NASA Astrophysics Data System (ADS)

    Chaplin, William J.; Basu, Sarbani

    2014-12-01

    The solar activity cycle can be studied using many different types of observations, such as counting sunspots, measuring emission in the Ca II H&K lines, magnetograms, radio emissions, etc. One of the more recent ways of studying solar activity is to use the changing properties of solar oscillations. Stellar activity cycles are generally studied using the Ca II lines, or sometimes using photometry. Asteroseismology is potentially an exciting means of studying these cycles. In this article we examine whether or not asteroseismic data can be used for this purpose, and what the asteroseismic signatures of stellar activity are. We also examine how asteroseismology may help in more indirect ways.

  12. COUPLING THE SOLAR DYNAMO AND THE CORONA: WIND PROPERTIES, MASS, AND MOMENTUM LOSSES DURING AN ACTIVITY CYCLE

    SciTech Connect

    Pinto, Rui F.; Brun, Allan Sacha; Grappin, Roland

    2011-08-20

    We study the connections between the Sun's convection zone and the evolution of the solar wind and corona. We let the magnetic fields generated by a 2.5-dimensional (2.5D) axisymmetric kinematic dynamo code (STELEM) evolve in a 2.5D axisymmetric coronal isothermal magnetohydrodynamic code (DIP). The computations cover an 11 year activity cycle. The solar wind's asymptotic velocity varies in latitude and in time in good agreement with the available observations. The magnetic polarity reversal happens at different paces at different coronal heights. Overall the Sun's mass-loss rate, momentum flux, and magnetic braking torque vary considerably throughout the cycle. This cyclic modulation is determined by the latitudinal distribution of the sources of open flux and solar wind and the geometry of the Alfven surface. Wind sources and braking torque application zones also vary accordingly.

  13. Estimating 11-year solar UV variations using 27-day response as a guide to isolate trends in total column ozone

    NASA Technical Reports Server (NTRS)

    Keating, G. M.; Brasseur, G. P.; Chiou, L. S.; Hsu, N. C.

    1994-01-01

    The total column ozone response to 11-year solar ultraviolet (UV) variations is estimated here from the observed response to 27-day solar variations adjusted for the theoretical difference between the 27-day response and 11-year response. The estimate is tested by comparing two data sets where long-term drifts have been removed, the Nimbus 7 TOMS Version 6 total column ozone and the 280 nm core-to-wing ratio (a proxy for solar UV variations). The 365-day running means of data area-weighted between 40 deg N to 40 deg S latitude give a 1.9% ozone variation related to the 11-year solar cycle compared with the estimate of 1.8%. Estimates of linear trends were reduced by a factor of 2 by including solar effects. The standard deviation from the empirical model was reduced from 1.0 to 0.6 Dobson Units, by including the quasi-biennial oscillation (QBO), but the QBO did not significantly alter trend estimates. Both the ozone responses to 27-day and 11-year solar variations were considerably stronger than predicted by a 2-D theoretical model.

  14. Forecasting the Peak of the Present Solar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Hamid, Rabab; Marzouk, Beshir

    2016-07-01

    Solar forecasting of the level of sun Activity is very important subject for all space programs. Most predictions are based on the physical conditions prevailing at or before the solar cycle minimum preceding the maximum in question. Our aim is to predict the maximum peak of cycle 24 using precursor techniques in particular those using spotless event, geomagnetic aa min. index and solar flux F10.7. Also prediction of exact date of the maximum (Tr) is taken in consideration. A study of variation over previous spotless event for cycles 7-23 and that for even cycles (8-22) are carried out for the prediction. Linear correlation between RM and spotless event around the preceding minimum gives RM24t = 101.9with rise time Tr = 4.5 Y. For the even cycles RM24e = 108.3 with rise time Tr = 3.9 Y. Based on the average aa min. index for the year of sunspot minimum cycles (13 - 23), we estimate the expected amplitude for cycle 24 to be RMaa = 116.5 for both the total and even cycles. Application of the data of solar flux F10.7 which cover only cycles (19-23) was taken in consideration and gives predicted maximum amplitude R24 10.7 = 146, which are over estimation. Our result indicating a somewhat weaker cycle 24 as compared to cycles 21-23.

  15. A solar cycle timing predictor - The latitude of active regions

    NASA Technical Reports Server (NTRS)

    Schatten, Kenneth H.

    1990-01-01

    A 'Spoerer butterfly' method is used to examine solar cycle 22. It is shown from the latitude of active regions that the cycle can now be expected to peak near November 1989 + or - 8 months, basically near the latter half of 1989.

  16. The connection between stellar activity cycles and magnetic field topology

    NASA Astrophysics Data System (ADS)

    See, V.; Jardine, M.; Vidotto, A. A.; Donati, J.-F.; Boro Saikia, S.; Bouvier, J.; Fares, R.; Folsom, C. P.; Gregory, S. G.; Hussain, G.; Jeffers, S. V.; Marsden, S. C.; Morin, J.; Moutou, C.; do Nascimento, J. D.; Petit, P.; Waite, I. A.

    2016-08-01

    Zeeman Doppler imaging has successfully mapped the large-scale magnetic fields of stars over a large range of spectral types, rotation periods and ages. When observed over multiple epochs, some stars show polarity reversals in their global magnetic fields. On the Sun, polarity reversals are a feature of its activity cycle. In this paper, we examine the magnetic properties of stars with existing chromospherically determined cycle periods. Previous authors have suggested that cycle periods lie on multiple branches, either in the cycle period-Rossby number plane or the cycle period-rotation period plane. We find some evidence that stars along the active branch show significant average toroidal fields that exhibit large temporal variations while stars exclusively on the inactive branch remain dominantly poloidal throughout their entire cycle. This lends credence to the idea that different shear layers are in operation along each branch. There is also evidence that the short magnetic polarity switches observed on some stars are characteristic of the inactive branch while the longer chromospherically determined periods are characteristic of the active branch. This may explain the discrepancy between the magnetic and chromospheric cycle periods found on some stars. These results represent a first attempt at linking global magnetic field properties obtained form ZDI and activity cycles.

  17. Butterfly Diagram and Activity Cycles in HR 1099

    NASA Astrophysics Data System (ADS)

    Berdyugina, Svetlana V.; Henry, Gregory W.

    2007-04-01

    We analyze photometric data of the active RS CVn-type star HR 1099 for the years 1975-2006 with an inversion technique and reveal the nature of two activity cycles of 15-16 yr and 5.3+/-0.1 yr duration. The 16 yr cycle is related to variations of the total spot area and is coupled with the differential rotation, while the 5.3 yr cycle is caused by the symmetric redistribution of the spotted area between the opposite stellar hemispheres (flip-flop cycle). We recover long-lived active regions comprising two active longitudes that migrate in the orbital reference frame with a variable rate because of the differential rotation along with changes in the mean spot latitudes. The migration pattern is periodic with the 16 yr cycle. Combining the longitudinal migration of the active regions with a previously measured differential rotation law, we recover the first stellar butterfly diagram without an assumption about spot shapes. We find that mean latitudes of active regions at opposite longitudes change antisymmetrically in the course of the 16 yr cycle: while one active region migrates to the pole, the other approaches the equator. This suggests a precession of the global magnetic field with respect to the stellar rotational axis.

  18. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.; Upton, Lisa

    2013-01-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow should also modulate the amplitude of the following sunspot cycle through its influence on the Sun's polar fields. The observational evidence and the theoretical consequences (similar to those of Cameron and Schussler (2012)) will be described.

  19. Meridional Flow Variations in Cycles 23 and 24: Active Latitude Control of Sunspot Cycle Amplitudes

    NASA Astrophysics Data System (ADS)

    Hathaway, David H.; Upton, L.

    2013-07-01

    We have measured the meridional motions of magnetic elements observed in the photosphere over sunspot cycles 23 and 24 using magnetograms from SOHO/MDI and SDO/HMI. Our measurements confirm the finding of Komm, Howard, and Harvey (1993) that the poleward meridional flow weakens at cycle maxima. Our high spatial and temporal resolution analyses show that this variation is in the form of a superimposed inflow toward the active latitudes. This inflow is weaker in cycle 24 when compared to the inflow in 23, the stronger cycle. This systematic modulation of the meridional flow should also modulate the amplitude of the following sunspot cycle through its influence on the Sun’s polar fields. The observational evidence and the theoretical consequences (similar to those of Cameron and Schussler (2012)) will be described. Komm, Howard, and Harvey (1993) Solar Phys. 147, 207. Cameron and Schussler (2012) Astron. Astrophys. 548, A57.

  20. Communicating the science of the 11-year sunspot cycle to the general public

    NASA Astrophysics Data System (ADS)

    Choudhuri, A. R.

    2015-03-01

    Astrophysics is one branch of science which excites the imagination of the general public. Pioneer science popularizers like George Gamow and Fred Hoyle wrote on different aspects of astrophysics. However, of late, we see a trend which I find disturbing. While it has become extremely fashionable to write popular science books on cosmology, other areas of astrophysics are grossly neglected.

  1. Geothermal activity helps life survive glacial cycles.

    PubMed

    Fraser, Ceridwen I; Terauds, Aleks; Smellie, John; Convey, Peter; Chown, Steven L

    2014-04-15

    Climate change has played a critical role in the evolution and structure of Earth's biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this "geothermal glacial refugia" hypothesis has yet been undertaken, but Antarctica provides a unique setting for doing so. The continent has experienced repeated glaciations that most models indicate blanketed the continent in ice, yet many Antarctic species appear to have evolved in almost total isolation for millions of years, and hence must have persisted in situ throughout. How could terrestrial species have survived extreme glaciation events on the continent? Under a hypothesis of geothermal glacial refugia and subsequent recolonization of nongeothermal regions, we would expect to find greater contemporary diversity close to geothermal sites than in nongeothermal regions, and significant nestedness by distance of this diversity. We used spatial modeling approaches and the most comprehensive, validated terrestrial biodiversity dataset yet created for Antarctica to assess spatial patterns of diversity on the continent. Models clearly support our hypothesis, indicating that geothermally active regions have played a key role in structuring biodiversity patterns in Antarctica. These results provide critical insights into the evolutionary importance of geothermal refugia and the history of Antarctic species. PMID:24616489

  2. Geothermal activity helps life survive glacial cycles

    PubMed Central

    Fraser, Ceridwen I.; Terauds, Aleks; Smellie, John; Convey, Peter; Chown, Steven L.

    2014-01-01

    Climate change has played a critical role in the evolution and structure of Earth’s biodiversity. Geothermal activity, which can maintain ice-free terrain in glaciated regions, provides a tantalizing solution to the question of how diverse life can survive glaciations. No comprehensive assessment of this “geothermal glacial refugia” hypothesis has yet been undertaken, but Antarctica provides a unique setting for doing so. The continent has experienced repeated glaciations that most models indicate blanketed the continent in ice, yet many Antarctic species appear to have evolved in almost total isolation for millions of years, and hence must have persisted in situ throughout. How could terrestrial species have survived extreme glaciation events on the continent? Under a hypothesis of geothermal glacial refugia and subsequent recolonization of nongeothermal regions, we would expect to find greater contemporary diversity close to geothermal sites than in nongeothermal regions, and significant nestedness by distance of this diversity. We used spatial modeling approaches and the most comprehensive, validated terrestrial biodiversity dataset yet created for Antarctica to assess spatial patterns of diversity on the continent. Models clearly support our hypothesis, indicating that geothermally active regions have played a key role in structuring biodiversity patterns in Antarctica. These results provide critical insights into the evolutionary importance of geothermal refugia and the history of Antarctic species. PMID:24616489

  3. A quest for activity cycles in low-mass stars

    NASA Astrophysics Data System (ADS)

    Vida, K.; Kriskovics, L.; Oláh, K.

    2013-11-01

    Long-term photometric measurements in a sample of ultrashort-period (P≈0.5 days or less) single and binary stars of different interior structures are analysed. A loose correlation exists between the rotational rate and cycle lengths of active stars, regardless of their evolutionary state and the corresponding physical parameters. The shortest cycles are expected for the fastest rotators of the order of 1-2 years, which is reported in this paper.

  4. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    NASA Astrophysics Data System (ADS)

    Herdiwijaya, Dhani; Arif, Johan; Nurzaman, Muhamad Zamzam; Astuti, Isna Kusuma Dewi

    2015-09-01

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth's climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth's global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity.

  5. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    SciTech Connect

    Herdiwijaya, Dhani; Arif, Johan; Nurzaman, Muhamad Zamzam; Astuti, Isna Kusuma Dewi

    2015-09-30

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth’s climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth’s global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity.

  6. Radio Imaging Observations of Solar Activity Cycle and Its Anomaly

    NASA Astrophysics Data System (ADS)

    Shibasaki, K.

    2011-12-01

    The 24th solar activity cycle has started and relative sunspot numbers are increasing. However, their rate of increase is rather slow compared to previous cycles. Active region sizes are small, lifetime is short, and big (X-class) flares are rare so far. We study this anomalous situation using data from Nobeyama Radioheliograph (NoRH). Radio imaging observations have been done by NoRH since 1992. Nearly 20 years of daily radio images of the Sun at 17 GHz are used to synthesize a radio butterfly diagram. Due to stable operation of the instrument and a robust calibration method, uniform datasets are available covering the whole period of observation. The radio butterfly diagram shows bright features corresponding to active region belts and their migration toward low latitude as the solar cycle progresses. In the present solar activity cycle (24), increase of radio brightness is delayed and slow. There are also bright features around both poles (polar brightening). Their brightness show solar cycle dependence but peaks around solar minimum. Comparison between the last minimum and the previous one shows decrease of its brightness. This corresponds to weakening of polar magnetic field activity between them. In the northern pole, polar brightening is already weakened in 2011, which means it is close to solar maximum in the northern hemisphere. Southern pole does not show such feature yet. Slow rise of activity in active region belt, weakening of polar activity during the minimum, and large north-south asymmetry in polar activity imply that global solar activity and its synchronization are weakening.

  7. Forecast for solar cycle 23 activity: a progress report

    NASA Astrophysics Data System (ADS)

    Ahluwalia, H. S.

    2001-08-01

    At the 25th International Cosmic Ray Conference (ICRC) at Durban, South Africa, I announced the discovery of a three cycle quasi-periodicity in the ion chamber data string assembled by me, for the 1937 to 1994 period (Conf. Pap., v. 2, p. 109, 1997). It corresponded in time with a similar quasi-periodicity observed in the dataset for the planetary index Ap. At the 26th ICRC at Salt Lake City, UT, I reported on our analysis of the Ap data to forecast the amplitude of solar cycle 23 activity (Conf. Pap., v. 2, pl. 260, 1999). I predicted that cycle 23 will be moderate (a la cycle 17), notwithstanding the early exuberant forecasts of some solar astronomers that cycle 23, "may be one of the greatest cycles in recent times, if not the greatest." Sunspot number data up to April 2001 indicate that our forecast appears to be right on the mark. We review the solar, interplanetary and geophysical data and describe the important lessons learned from this experience. 1. Introduction Ohl (1971) was the first to realize that Sun may be sending us a subliminal message as to its intent for its activity (Sunspot Numbers, SSN) in the next cycle. He posited that the message was embedded in the geomagnetic activity (given by sum Kp). Schatten at al (1978) suggested that Ohl hypothesis could be understood on the basis of the model proposed by Babcock (1961) who suggested that the high latitude solar poloidal fields, near a minimum, emerge as the toroidal fields on opposite sides of the solar equator. This is known as the Solar Dynamo Model. One can speculate that the precursor poloidal solar field is entrained in the high speed solar wind streams (HSSWS) from the coronal holes which are observed at Earth's orbit during the descending phase of the previous cycle. The interaction

  8. Cycle Length Dependence of Stellar Magnetic Activity and Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Choi, Hwajin; Lee, Jeongwoo; Oh, Suyeon; Kim, Bogyeong; Kim, Hoonkyu; Yi, Yu

    2015-03-01

    Solar cycle (SC) 23 was extraordinarily long with remarkably low magnetic activity. We have investigated whether this is a common behavior of solar-type stars. From the Ca ii H and K line intensities of 111 stars observed at Mount Wilson Observatory from 1966 to 1991, we have retrieved data of all 23 G-type stars and recalculated their cycle lengths using the damped least-squares method for the chromospheric activity index S as a function of time. A regression analysis was performed to find relations between the derived cycle length, Pavg, and the index for excess chromospheric emission, RHK\\prime . As a noteworthy result, we found a segregation between young and old solar-type stars in the cycle length-activity correlation. We incorporated the relation for the solar-type stars into the previously known rule for stellar chromospheric activity and brightness to estimate the variation of solar brightness from SC 22 to SC 23 as (0.12 ± 0.06)%, much higher than the actual variation of total solar irradiance (TSI) ≤0.02%. We have then examined solar spectral irradiance (SSI) to find a good phase correlation with a sunspot number in the wavelength range of 170-260 nm, which is close to the spectral range effective in heating the Earth’s atmosphere. Therefore, it appears that SSI rather than TSI is a good indicator of the chromospheric activity, and its cycle length dependent variation would be more relevant to the possible role of the Sun in the cyclic variation of the Earth’s atmosphere.

  9. Variation of Meteor Heights and Solar-Cycle Activity

    NASA Astrophysics Data System (ADS)

    Porubcan, Vladimír; Bucek, Marek; Cevolani, Giordano; Zigo, Pavel

    2012-08-01

    Photographic meteor observations of the Perseid meteoroid stream compiled from the IAU Meteor Data Center catalogue are analyzed from the viewpoint of possible long-term variation of meteor heights with the solar-cycle activity, which was previously reported from radio observations. The observed beginning and end-point heights of the Perseids, normalized for the geocentric velocity and the absolute photographic magnitude, do not show a variation consistent with the solar-cycle activity. This result is valid for the mass range of larger meteoroids observed by photographic techniques, and must be still verified also for the range of smaller meteoroids observed by TV and radio methods.

  10. Hierarchical Reproductive Allocation and Allometry within a Perennial Bunchgrass after 11 Years of Nutrient Addition

    PubMed Central

    Tian, Dashuan; Pan, Qingmin; Simmons, Matthew; Chaolu, Hada; Du, Baohong; Bai, Yongfei; Wang, Hong; Han, Xingguo

    2012-01-01

    Bunchgrasses are one of the most important plant functional groups in grassland ecosystems. Reproductive allocation (RA) for a bunchgrass is a hierarchical process; however, how bunchgrasses adjust their RAs along hierarchical levels in response to nutrient addition has never been addressed. Here, utilizing an 11-year nutrient addition experiment, we examined the patterns and variations in RA of Agropyron cristatum at the individual, tiller and spike levels. We evaluated the reproductive allometric relationship at each level by type II regression analysis to determine size-dependent and size-independent effects on plant RA variations. Our results indicate that the proportion of reproductive individuals in A. cristatum increased significantly after 11 years of nutrient addition. Adjustments in RA in A. cristatum were mainly occurred at the individual and tiller levels but not at the spike level. A size-dependent effect was a dominant mechanism underlying the changes in plant RA at both individual and tiller levels. Likewise, the distribution of plant size was markedly changed with large individuals increasing after nutrient addition. Tiller-level RA may be a limiting factor for the adjustment of RA in A. cristatum. To the best of our knowledge, this study is the first to examine plant responses in terms of reproductive allocation and allometry to nutrient enrichment within a bunchgrass population from a hierarchical view. Our findings have important implications for understanding the mechanisms underlying bunchgrass responses in RA to future eutrophication due to human activities. In addition, we developed a hierarchical analysis method for disentangling the mechanisms that lead to variation in RA for perennial bunchgrasses. PMID:22984408

  11. Successful treatment of florid cutaneous warts with intravenous cidofovir in an 11-year-old girl.

    PubMed

    Cusack, Caitriona; Fitzgerald, Deborah; Clayton, Timothy M; Irvine, Alan D

    2008-01-01

    Cutaneous warts, commonly seen in children and the immunosuppressed are socially distressing and are often resistant to traditional treatments. Here, we report an 11-year-old girl with bilateral florid verrucous lesions on her hands, feet and chin, which were refractory to a number of standard treatments including cryotherapy, cantharidin preparations, topical salicylic acid, surgical debulking techniques, oral Cimetidine, and topical and intralesional Cidofovir. As the disfiguring lesions had a marked adverse effect on her quality of life, a trial of IV Cidofovir was instituted. We administered five cycles of IV Cidofovir with a 1-week interval between the first and second treatment, followed by 2-week intervals thereafter. This regime was well tolerated and we report dramatic resolution of the lesions with persistent clearance 6 months after completion of the fifth infusion. Resolution of recalcitrant warts with IV Cidofovir has been reported in a limited number of cases. Our experience supports its efficacy in this setting, and to the best of our knowledge this is the first report of successful treatment of cutaneous warts with IV Cidofovir in a pediatric case. PMID:18577053

  12. MAGNETIC ACTIVITY CYCLES IN THE EXOPLANET HOST STAR {epsilon} ERIDANI

    SciTech Connect

    Metcalfe, T. S.; Mathur, S.; Buccino, A. P.; Mauas, P. J. D.; Petrucci, R.; Brown, B. P.; Soderblom, D. R.; Henry, T. J.; Hall, J. C.; Basu, S.

    2013-02-01

    The active K2 dwarf {epsilon} Eri has been extensively characterized both as a young solar analog and more recently as an exoplanet host star. As one of the nearest and brightest stars in the sky, it provides an unparalleled opportunity to constrain stellar dynamo theory beyond the Sun. We confirm and document the 3-year magnetic activity cycle in {epsilon} Eri originally reported by Hatzes and coworkers, and we examine the archival data from previous observations spanning 45 years. The data show coexisting 3-year and 13-year periods leading into a broad activity minimum that resembles a Maunder minimum-like state, followed by the resurgence of a coherent 3-year cycle. The nearly continuous activity record suggests the simultaneous operation of two stellar dynamos with cycle periods of 2.95 {+-} 0.03 years and 12.7 {+-} 0.3 years, which, by analogy with the solar case, suggests a revised identification of the dynamo mechanisms that are responsible for the so-called 'active' and 'inactive' sequences as proposed by Boehm-Vitense. Finally, based on the observed properties of {epsilon} Eri, we argue that the rotational history of the Sun is what makes it an outlier in the context of magnetic cycles observed in other stars (as also suggested by its Li depletion), and that a Jovian-mass companion cannot be the universal explanation for the solar peculiarities.

  13. Predicting the Sunspot Cycle

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.

    2009-01-01

    The 11-year sunspot cycle was discovered by an amateur astronomer in 1844. Visual and photographic observations of sunspots have been made by both amateurs and professionals over the last 400 years. These observations provide key statistical information about the sunspot cycle that do allow for predictions of future activity. However, sunspots and the sunspot cycle are magnetic in nature. For the last 100 years these magnetic measurements have been acquired and used exclusively by professional astronomers to gain new information about the nature of the solar activity cycle. Recently, magnetic dynamo models have evolved to the stage where they can assimilate past data and provide predictions. With the advent of the Internet and open data policies, amateurs now have equal access to the same data used by professionals and equal opportunities to contribute (but, alas, without pay). This talk will describe some of the more useful prediction techniques and reveal what they say about the intensity of the upcoming sunspot cycle.

  14. The Solar Non-activity Cycle of Polar Coronal Holes

    NASA Astrophysics Data System (ADS)

    Kirk, M. S.; Pesnell, W. D.; Young, C. A.

    2015-12-01

    After the unusually extended minimum in 2008 and 2009, solar cycle 24 continues to be an exceptionally weak cycle both in sunspot number and number of large magnetic storms. Coronal holes offer a direct measurement of the non-activity solar cycle, a missing link in our understanding of solar cycle progression. They are prevalent during solar minimum, non-axisymmetric, and are stable. Polar coronal holes are regularly observed capping the northern and southern solar poles in EUV images of the corona and are understood as the primary source of the fast solar wind. We make measurements of these features from 1996 through 2015 using four different NASA imagers: SOHO EIT, STEREO A and B EUVI, and SDO AIA. A measurement of the axial symmetry of the polar holes is seen to have clear solar cycle dependence. Polar coronal holes are aligned with the solar rotation axis during minimum and have a maximum asymmetry between holes of about 14 degrees in the declining phase of the current solar cycle.

  15. Periods of activity cycles in late-type stars

    NASA Technical Reports Server (NTRS)

    Kliorin, N. I.; Ruzmaykin, A. A.; Sokolov, D. D.

    1983-01-01

    The mean magnetic field dynamo theory is utilized to obtain the qualitative dependence of the period of activity on the angular velocity of rotation for stars with sufficiently extensive convective shells. The dependence of the cycle period on the spectral class is also discussed.

  16. A cycling workstation to facilitate physical activity in office settings.

    PubMed

    Elmer, Steven J; Martin, James C

    2014-07-01

    Facilitating physical activity during the workday may help desk-bound workers reduce risks associated with sedentary behavior. We 1) evaluated the efficacy of a cycling workstation to increase energy expenditure while performing a typing task and 2) fabricated a power measurement system to determine the accuracy and reliability of an exercise cycle. Ten individuals performed 10 min trials of sitting while typing (SIT type) and pedaling while typing (PED type). Expired gases were recorded and typing performance was assessed. Metabolic cost during PED type was ∼ 2.5 × greater compared to SIT type (255 ± 14 vs. 100 ± 11 kcal h(-1), P < 0.01). Typing time and number of typing errors did not differ between PED type and SIT type (7.7 ± 1.5 vs. 7.6 ± 1.6 min, P = 0.51, 3.3 ± 4.6 vs. 3.8 ± 2.7 errors, P = 0.80). The exercise cycle overestimated power by 14-138% compared to actual power but actual power was reliable (r = 0.998, P < 0.01). A cycling workstation can facilitate physical activity without compromising typing performance. The exercise cycle's inaccuracy could be misleading to users. PMID:24681071

  17. Activity Cycles in Stars with Highly Active Chromospheres

    NASA Astrophysics Data System (ADS)

    Guinan, Edward F.

    The extended lifetime of the IUE satellite has provided an unique and unanticipated opportunity to examine the long-term evolution of magnetic activity on active chromospheric stars. We propose to obtain further IUE observations of the highly active RS CVn stars V711 Tauri, lambda Andromedae, II Pegasi, and UX Arietis in conjunction with groundbased optical and radio observations, and possibly ROSAT X-ray observations. In addition we would continue IUE observations of the unusual rapidly rotating early G giant, FK Comae, which, although not in the RS CVn category, shares a similarly high level of magnetic activity. These five stars have the most extensive IUE archival coverage for stars of their type and have almost continuous ground-based photometric coverage from about 1975 onward. We aim to trace the long-term development of magnetic activity on these stars: a detailed study of the UV emission-like fluxes will enable us to follow the variations in chromospheric and transition-region activity over an interval of 12-16 years. Optical observations reveal variations in photospheric (starspot) activity: the starspot regions are large (up to 30% of the stellar surface) and vary significantly with time. The main aim of the proposed research is to examine the relationship between chromospheric, transition-region, and photospheric active regions. Elucidation of the role of white-light faculae vis-a-vis spots in effecting stellar irradiance changes is also desirable.

  18. The evolution and orientation of early cycle 22 active regions

    NASA Technical Reports Server (NTRS)

    Cannon, Anne T.; Marquette, William H.

    1991-01-01

    The evolution of six major active regions which appeared during the first phase of the present solar cycle (cycle 22) has been studied. It was found that the northern hemisphere regions exhibited a broad range of evolutionary behavior in which the commonly accepted 'normal pattern' (whereby the follower flux moves preferentially polewards ahead of the leader flux) is represented at one end of the range. At the other end of the range, the leader flux is displaced polewards of the follower flux. In the latter cases equatorward extensions of the polar coronal hole are noted.

  19. The active RS Canum Venaticorum binary II Pegasi. IV. The SPOT activity cycle

    NASA Astrophysics Data System (ADS)

    Berdyugina, S. V.; Berdyugin, A. V.; Ilyin, I.; Tuominen, I.

    1999-10-01

    A total of 6 new surface images of II Peg obtained for the years 1997 and 1998 confirms the recently revealed permanent active longitude structure. The lower limit of the active longitudes' lifetime is now extended up to 25 years. A new ``flip-flop'' phenomenon, redefined as a switch of the activity between the active longitudes, has started in summer of 1998. It coincides reasonably well with the moment predicted from the activity cycle of the star. This confirms definitely the cyclic behaviour of the activity of II Peg we recently discovered. Therefore, we assign numbers to the cycles of 4.65 yr since the earliest photoelectric observations of II Peg and define the active longitudes as ``odd'' and ``even'' corresponding to odd and even numbers of cycles. With such a definition, in late 1998 the 7th cycle began and the ``odd'' active longitude became more active. From the analysis of the spot area evolution within the active longitudes we conclude that the activity cycle is developed as a rearrangement of the nearly constant amount of the spot area between the active longitudes. We discuss the ``flip-flop'' phenomenon as a tracer of stellar activity and the role of the unseen secondary in establishing the cycle. Based on observations collected at the Nordic Optical Telescope (NOT), La Palma, Spain; the 1.25m telescope of the Crimean Astrophysical Observatory, Ukraine; the Phoenix 10 robotic telescope, APT Observatory, Arizona, USA.}

  20. SOLAR ROTATION RATE DURING THE CYCLE 24 MINIMUM IN ACTIVITY

    SciTech Connect

    Antia, H. M.; Basu, Sarbani E-mail: sarbani.basu@yale.ed

    2010-09-01

    The minimum of solar cycle 24 is significantly different from most other minima in terms of its duration as well as its abnormally low levels of activity. Using available helioseismic data that cover epochs from the minimum of cycle 23 to now, we study the differences in the nature of the solar rotation between the minima of cycles 23 and 24. We find that there are significant differences between the rotation rates during the two minima. There are differences in the zonal-flow pattern too. We find that the band of fast rotating region close to the equator bifurcated around 2005 and recombined by 2008. This behavior is different from that during the cycle 23 minimum. By autocorrelating the zonal-flow pattern with a time shift, we find that in terms of solar dynamics, solar cycle 23 lasted for a period of 11.7 years, consistent with the result of Howe et al. (2009). The autocorrelation coefficient also confirms that the zonal-flow pattern penetrates through the convection zone.

  1. Activity Scratchpad Prototype: Simplifying the Rover Activity Planning Cycle

    NASA Technical Reports Server (NTRS)

    Abramyan, Lucy

    2005-01-01

    The Mars Exploration Rover mission depends on the Science Activity Planner as its primary interface to the Spirit and Opportunity Rovers. Scientists alternate between a series of mouse clicks and keyboard inputs to create a set of instructions for the rovers. To accelerate planning by minimizing mouse usage, a rover planning editor should receive the majority of inputted commands from the keyboard. Thorough investigation of the Eclipse platform's Java editor has provided the understanding of the base model for the Activity Scratchpad. Desirable Eclipse features can be mapped to specific rover planning commands, such as auto-completion for activity titles and content assist for target names. A custom editor imitating the Java editor's features was created with an XML parser for experimenting purposes. The prototype editor minimized effort for redundant tasks and significantly improved the visual representation of XML syntax by highlighting keywords, coloring rules, folding projections, and providing hover assist, templates and an outline view of the code.

  2. Integrated gasification combined-cycle research development and demonstration activities

    SciTech Connect

    Ness, H.M.; Reuther, R.B.

    1995-12-01

    The United States Department of Energy (DOE) has selected six integrated gasification combined-cycle (IGCC) advanced power systems for demonstration in the Clean Coal Technology (CCT) Program. DOE`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D) program that supports the CCT program, and addresses long-term improvements in support of IGCC technology. This overview briefly describes the CCT projects and the supporting RD&D activities.

  3. Effects of turbulent pumping on stellar activity cycles

    NASA Astrophysics Data System (ADS)

    Do Cao, O.; Brun, A. S.

    2011-12-01

    Stellar magnetic activity of solar like stars is thought to be due to an internal dynamo. While the Sun has been the subject of intense research for refining dynamo models, observations of magnetic cyclic activity in solar type stars have become more and more available, opening a new path to understand the underlying physics behind stellar cycles. For instance, it is key to understand how stellar rotation rate influences magnetic cycle period P_cyc. Recent numerical simulations of advection-dominated Babcock Leighton models have demonstrated that it is difficult to explain this observed trend given a) the strong influence of the cycle period to the meridional circulation amplitude and b) the fact that 3D models indicate that meridional flows become weaker as the rotation rate increases. In this paper, we introduce the turbulent pumping mechanism as another advective process capable also of transporting the magnetic fields. We found that this model is now able to reproduce the observations under the assumption that this effect increases as \\Omega2. The turbulent pumping becomes indeed another major player able to circumvent the meridional circulation. However, for high rotation rates (\\Omega ≃ 5 \\Omega_⊙), its effects dominate those of the meridional circulation, entering a new class of regime dominated by the advection of turbulent pumping and thus leading to a cyclic activity qualitatively different from that of the Sun.

  4. Somatotype in 6-11-year-old Italian and Estonian schoolchildren.

    PubMed

    Ventrella, A R; Semproli, S; Jürimäe, J; Toselli, S; Claessens, A L; Jürimäe, T; Brasili, P

    2008-01-01

    The study of somatotypes can contribute to the understanding of variability in human body build. The aim of this study was to compare the somatotypes of Italian and Estonian schoolchildren in order to evaluate factors that might lead to variability in somatotypes. The sample consisted of 762 Italian and 366 Estonian children aged 6-11 years. They were somatotyped by the Heath-Carter anthropometric method. Data on organised extra-curricular physical activity and hours of weekly training were also collected. One-way ANOVA was used to evaluate country-related variations of somatotype in each age/sex group, while factorial ANOVA was used to test the influence of country and organised physical activity on the variability of the anthropometric characteristics and somatotype components. There are significant differences in mean somatotypes between the Italian and Estonian children in many age classes and a different constitutional trend in children from the two different countries is observed. The Italian children are more endomorphic and less mesomorphic and ectomorphic than the Estonian children. On the other hand, it emerges from factorial ANOVA, that the somatotype components do not present significant variations related to organised physical activity and to the interaction between the country of origin and sport practice. Moreover, the results of the forward stepwise discriminant analyses show that mesomorphy is the best discriminator between the two countries, followed by ectomorphy. Our findings suggest that the observed differences between Italian and Estonian children could be related mainly to country rather than to the practice of organised physical activity in the two countries. PMID:18995850

  5. Magnetic Cloud Polarity and Geomagnetic Activities over Three Solar Cycles

    NASA Astrophysics Data System (ADS)

    Li, Y.; Luhmann, J.

    2006-12-01

    Interplanetary coronal mass ejections (ICMEs) that show fluxrope magnetic structures are named magnetic clouds (MCs). Majority of the MCs exhibit bipolar signature in their north-south component (Bz) in IMF measurements. The Bz component of a bipolar cloud is either NS (north first then turning south as the MC traverses the spacecraft) or SN. Studies show that the occurrence of these two types of MCs has some solar cycle dependence. However it appears to be a complex relationship as the switch between the two types of MCs is not concurrent with either the solar polar reversal or the time of the sunspot minimum when the new cycle sunspots start to appear. In this paper, we use ACE solar wind and IMF observations to obtain the most updated MC signatures and their temporal variation. In combination with our previously published results, we analyze MC polarity variations over the three solar cycles of 21, 22 and 23. Interpretations in terms of their solar sources will be attempted. On the other hand, the geomagnetic activities over the same solar cycles will be studied using geomagnetic indices. The geoeffectiveness of the MC will be evaluated in the aid of Dst indices.

  6. Estrus cycle effect on muscle tyrosine kinase activity in bitches.

    PubMed

    Gomes Pöppl, Álan; Costa Valle, Sandra; Hilário Díaz González, Félix; de Castro Beck, Carlos Afonso; Kucharski, Luiz Carlos; Silveira Martins Da Silva, Roselis

    2012-03-01

    Estrus cycle is a well recognized cause of insulin resistance in bitches. The insulin receptor (IR) as well as the insulin-like growth factor-I receptor belong to the same subfamily of tyrosine kinase (TK) receptors. The objective of this study was to evaluate basal TK activity in muscle tissue of bitches during the estrus cycle. Twenty-four bitches were used in the study (7 in anestrus, 7 in estrus, and 10 in diestrus). Muscle samples, taken after spaying surgery to determine TK activity, were immediately frozen in liquid nitrogen and then stored at -80°C until the membranes were prepared by sequential centrifugation after being homogenized. TK activity was determined by Poly (Glu 4:Tyr 1) phosphorylation and expressed in cpm/μg of protein. TK activity was significantly lower (P < 0.001) in the animals in estrus (104.5 ± 11.9 cpm/μg of protein) and diestrus (94.5 ± 16.9 cpm/μg of protein) when compared with bitches in anestrus (183.2 ± 39.2 cpm/μg of protein). These results demonstrate, for the first time, lower basal TK activity in the muscle tissue of female dogs during estrus and diestrus, which may represent lower insulin signaling capacity, opening a new field of investigation into the molecular mechanisms of insulin resistance in dogs. PMID:22139063

  7. The Cell Cycle: An Activity Using Paper Plates to Represent Time Spent in Phases of the Cell Cycle

    ERIC Educational Resources Information Center

    Scherer, Yvette D.

    2014-01-01

    In this activity, students are given the opportunity to combine skills in math and geometry for a biology lesson in the cell cycle. Students utilize the data they collect and analyze from an online onion-root-tip activity to create a paper-plate time clock representing a 24-hour cell cycle. By dividing the paper plate into appropriate phases of…

  8. Changes in the activity budget of cycling female chimpanzees.

    PubMed

    Matsumoto-Oda, A; Oda, R

    1998-01-01

    This study is a preliminary report on the time allocated to various activities by female wild chimpanzees (Pan troglodytes schweinfurthii) during their sexual cycle. Cycling females with maximal tumescence (estrous females) tended to spend more time moving than cycling females with quiescent sexual skin (anestrous females). Although there was no statistically significant decrease in any specific activity that corresponded to the increase in time spent moving, feeding time did decrease in four of the five females. The frequency of approach by females toward males and the frequency of approach by males toward females significantly increased when females were in estrus. Direct aggression by males occurred more frequently toward estrous females than toward anestrous females. The copulation frequency and the frequency of approach to males was not significantly correlated with the increase in time spent moving. There was a high but not significant correlation between the time spent moving and the frequency of direct aggression by males toward females. Mating effort, feeding competition, male aggression, and other possible reasons that might explain the increase in moving time are discussed. PMID:9773678

  9. Solar Activity in the Green Corona Over Cycle 23

    NASA Astrophysics Data System (ADS)

    Rušin, V.

    2006-12-01

    The intensity of the green coronal line (5303Å, Fe {\\sc xiv), which is directly proportional to the electron density as well as the temperature of the corona, is a good and sensitive indicator of the reflection of the photospheric activity in the emission corona, mapping also the evolution of the magnetic fields in the active regions on the solar surface. In cycle 23 (1996 -2007), the average intensity of the green corona was of about 30% less when compared with that of the preceding cycle; this, however, does not necessarily imply a lower temperature of the corona, but rather a smaller number of active regions and/or smaller strength of local magnetic fields in the latter. The maximum of the intensity of the green corona was observed in August 2001, preceding for about one and a half year that of sunspot number. Moreover, the increased intensities were not observed continuously in time and heliographic latitude, but rather in particular latitudes, with a slight time-lag between the north and south hemispheres. It is well known that a time-latitudinal distribution of the intensity of the green corona features two kinds of large-scale motions. The first is the so-called polar branch, which separates from the "main flow" in the middle latitudes in the cycle minimum, lasts for about 3 -4 years and disappears at the time of the maxima of solar activity near the poles. The other is the equatorial (or principal) branch, which after separation in middle-latitudes moves first towards the poles, then roughly 2 years after the polar branch reached the poles makes a U-turn at upper heliographic latitudes of ±70 degrees, and migrates towards the equator where it disappears in the next minimum; the life-time of this branch is about 18 years. Given the time of the splitting of the two branches, we can guess the time of the maximum and minimum of the forthcoming cycle - cycle 24: the corresponding numbers are 2011 and 2012.5 for the time of the "double" maximum and 2019 for

  10. The variations of prominence activities during solar cycle

    NASA Astrophysics Data System (ADS)

    Shimojo, Masumi

    The prominence activities (prominence eruption/disappearance) in the solar atmosphere closely relate with the CMEs that cause great influences on heliosphere and magnetosphere. Gopal-swarmy et al. (2003) reported that 72 The Nobeyama Radioheliograph (NoRH) is observing Sun in microwave (17 GHz) since 1992. At a flare, the main component of the microwave from Sun is emitted from non-thermal electrons that are accelerated by flare. On the other hand, the main component of the microwave is thermal emission when Sun is quiet, and a prominence is clearly observed in microwave because there is the prominence on the limb. We developed the automatic prominence activity detection program based on 17 GHz images observed by NoRH, and investigated the variation of the properties of the prominence activities that oc-curred from 1992 to the end of 2009. We found the following results. 1. The variation in the number of prominence activities is similar to that of sunspots during one solar cycle but there are differences between the peak times of prominence activities and sunspots. 2. The frequency distribution as a function of the magnitude of the prominence activities the size of activated prominences at each phase shows a power-law distribution. The power-law index of the distribution does not change except around the solar minimum. 3. The number of promi-nence activities has a dependence on the latitude On the other hand the average magnitude is independent of the latitude. In the paper, we will also discuss the relationship the other properties of prominence eruptions, solar cycle and the photospheric magnetic field.

  11. Effects of solar cycle 24 activity on WAAS navigation

    NASA Astrophysics Data System (ADS)

    Datta-Barua, Seebany; Walter, Todd; Bust, Gary S.; Wanner, William

    2014-01-01

    This paper reviews the effects of geomagnetic activity of solar cycle 24 from 2011 through mid-2013 on the Federal Aviation Administration's Wide Area Augmentation System (WAAS) navigation service in the U.S., to identify (a) major impacts and their severity compared with the previous cycle and (b) effects in new service regions of North America added since last solar cycle. We examine two cases: a storm that reduced service coverage for several hours and ionospheric scintillation that led to anomalous receiver tracking. Using the 24-25 October 2011 storm as an example, we examine WAAS operational system coverage for the conterminous U.S. (CONUS). The WAAS algorithm upgrade to ionospheric estimation, in effect since late 2011, is able to mitigate the daytime coverage loss but not the nighttime loss. We correlate WAAS availability to maps of the storm plasma generated with the data assimilative model Ionospheric Data Assimilation 4-D, which show a local nighttime corotating persistent plume of plasma extending from Florida across central CONUS. We study the effect of scintillation on 9 October 2012 on the WAAS reference station at Fairbanks, Alaska. Data from a nearby scintillation monitor in Gakona and all-sky imaging of aurora at Poker Flat corroborate the event. Anomalous receiver processing triggered by scintillation reduces accuracy at Fairbanks for a few minutes. Users experiencing similar effects would have their confidence bounds inflated, possibly trading off service continuity for safety. The activity to date in solar cycle 24 has had minor effects on WAAS service coverage, mainly occurring in Alaska and Canada.

  12. Effects of long-period solar activity fluctuation on temperature and pressure of the terrestrial atmosphere

    NASA Technical Reports Server (NTRS)

    Rubashev, B. M.

    1978-01-01

    The present state of research on the influence of solar sunspot activity on tropospheric temperature and pressure is reviewed. The existence of an 11-year temperature cycle of 5 different types is affirmed. A cyclic change in atmospheric pressure, deducing characteristic changes between 11-year cycles is discussed. The existence of 80-year and 5-to-6-year cycles of temperature is established, and physical causes for birth are suggested.

  13. A new simple dynamo model for solar activity cycle

    NASA Astrophysics Data System (ADS)

    Yokoi, Nobumitsu; Schmitt, Dieter

    2015-04-01

    The solar magnetic activity cycle has been investigated in an elaborated manner with several types of dynamo models [1]. In most of the current mean-field approaches, the inhomogeneity of the large-scale flow is treated as an essential ingredient in the mean magnetic field equation whereas it is completely neglected in the turbulence equation. In this work, a new simple model for the solar activity cycle is proposed. The present model differs from the previous ones mainly in two points. First, in addition to the helicity coefficient α, we consider a term related to the cross helicity, which represents the effect of the inhomogeneous mean flow, in the turbulent electromotive force [2, 3]. Second, this transport coefficient (γ) is not treated as an adjustable parameter, but the evolution equation for γ is simultaneously solved. The basic scenario for the solar activity cycle in this approach is as follows: The toroidal field is induced by the toroidal rotation in mediation by the turbulent cross helicity. Then due to the α or helicity effect, the poloidal field is generated from the toroidal field. The poloidal field induced by the α effect produces a turbulent cross helicity whose sign is opposite to the original one (negative cross-helicity production). The cross helicity with this opposite sign induces a reversed toroidal field. Results of the eigenvalue analysis of the model equations are shown, which confirm the above scenario. References [1] Charbonneau, Living Rev. Solar Phys. 7, 3 (2010). [2] Yoshizawa, A. Phys. Fluids B 2, 1589 (1990). [3] Yokoi, N. Geophys. Astrophys. Fluid Dyn. 107, 114 (2013).

  14. Sunspot Activity Near Cycle Minimum and What it Might Suggest for Cycle 24, the Next Sunspot Cycle

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2009-01-01

    In late 2008, 12-month moving averages of sunspot number, number of spotless days, number of groups, area of sunspots, and area per group were reflective of sunspot cycle minimum conditions for cycle 24, these values being of or near record value. The first spotless day occurred in January 2004 and the first new-cycle, high-latitude spot was reported in January 2008, although old-cycle, low-latitude spots have continued to be seen through April 2009, yielding an overlap of old and new cycle spots of at least 16 mo. New-cycle spots first became dominant over old-cycle spots in September 2008. The minimum value of the weighted mean latitude of sunspots occurred in May 2007, measuring 6.6 deg, and the minimum value of the highest-latitude spot followed in June 2007, measuring 11.7 deg. A cycle length of at least 150 mo is inferred for cycle 23, making it the longest cycle of the modern era. Based on both the maximum-minimum and amplitude-period relationships, cycle 24 is expected to be only of average to below-average size, peaking probably in late 2012 to early 2013, unless it proves to be a statistical outlier.

  15. Sources of solar wind over the solar activity cycle.

    PubMed

    Poletto, Giannina

    2013-05-01

    Fast solar wind has been recognized, about 40 years ago, to originate in polar coronal holes (CHs), that, since then, have been identified with sources of recurrent high speed wind streams. As of today, however, there is no general consensus about whether there are, within CHs, preferential locations where the solar wind is accelerated. Knowledge of slow wind sources is far from complete as well. Slow wind observed in situ can be traced back to its solar source by backward extrapolation of magnetic fields whose field lines are streamlines of the outflowing plasma. However, this technique often has not the necessary precision for an indisputable identification of the region where wind originates. As the Sun progresses through its activity cycle, different wind sources prevail and contribute to filling the heliosphere. Our present knowledge of different wind sources is here summarized. Also, a Section addresses the problem of wind acceleration in the low corona, as inferred from an analysis of UV data, and illustrates changes between fast and slow wind profiles and possible signatures of changes along the solar cycle. A brief reference to recent work about the deep roots of solar wind and their changes over different solar cycles concludes the review. PMID:25685421

  16. Trauma, mental health, and intergenerational associations in Kosovar Families 11 years after the war

    PubMed Central

    Schick, Matthis; Morina, Naser; Klaghofer, Richard; Schnyder, Ulrich; Müller, Julia

    2013-01-01

    Background While there is a considerable amount of literature addressing consequences of trauma in veterans and holocaust survivors, war and postwar civilian populations, particularly children, are still understudied. Evidence regarding intergenerational effects of trauma in families is inconsistent. Objective To shed light on intergenerational aspects of trauma-related mental health problems among families 11 years after the Kosovo war. Method In a cross-sectional study, a paired sample of 51 randomly selected triplets (school-aged child, mother, father, N=153) of Kosovar families was investigated with regard to trauma exposure, posttraumatic stress (UCLA Posttraumatic Diagnostic Scale), anxiety (Spence Children's Anxiety Scale, Hopkins Symptom Checklist-25), and depressive symptoms (Depressionsinventar für Kinder und Jugendliche [DIKJ; depression inventory for children and adolescents], Hopkins Symptom Checklist-25). Results Considerable trauma exposure and high prevalence rates of clinically relevant posttraumatic stress, anxiety, and depressive symptoms were found in both parents and children. While strong correlations were found between children's depressive symptoms and paternal posttraumatic stress, anxiety and depressive symptoms, maternal symptoms did not correlate with their children's. In multiple regression analyses, only posttraumatic stress symptoms of fathers were significantly related with children's depressive symptoms. Conclusion Eleven years after the Kosovo war, the presence of posttraumatic stress, anxiety, and depressive symptoms in civilian adults and their children is still substantial. As symptoms of parents and children are associated, mental health problems of close ones should be actively screened and accounted for in comprehensive treatment plans, using a systemic approach. Future research should include longitudinal studies conducting multivariate analyses with larger sample sizes in order to investigate indicators, causal and

  17. Antimicrobial Susceptibility of Invasive Streptococcus pneumoniae Isolates in Portugal over an 11-Year Period

    PubMed Central

    Dias, Ricardo; Louro, Deolinda; Caniça, Manuela

    2006-01-01

    This national surveillance study presents the in vitro activities of the main antimicrobial agents against 1,331 S. pneumoniae isolates as tested by an agar dilution method according to the guidelines of the Clinical and Laboratory Standards Institute (formerly NCCLS). The strains were isolated in several regions of Portugal from cases of invasive disease over an 11-year period (1994 to 2004). This study shows that the percentage of penicillin-nonsusceptible strains increased from 12% in 1994 to 28.5% in 2000. Then the rate declined to 17.7% in 2003 but increased again to 23.2% in 2004. Nevertheless, the rate of highly resistant isolates declined consistently, to 0.9% in 2001 to 2004. Ceftriaxone- and cefotaxime-nonsusceptible isolates became less frequent, from 4% and 8%, respectively, in 1994 to ≤1% in 2004. The macrolide-lincosamide-streptogramin B phenotype was the predominant macrolide phenotype found. The increase in the percentage of isolates that were only nonsusceptible to erythromycin (3.7% in 1994 to 1998 to 9.1% in 2002 to 2004) was similar to that for isolates with coresistance to penicillin and erythromycin (3.3% in 1994 to 1998 to 9.1% in 2002 to 2004). The nonsusceptibility to ciprofloxacin increased during recent years, from 0.5% in 2002 to 3.5% in 2004. Multidrug resistance also increased in recent years: from 7.9% in 2002 to 15.6% in 2004. The increasing use of macrolides could be causing the increase in penicillin and multidrug resistance, due to the coresistance to macrolides. The use of penicillin to treat empirical invasive pneumococci infections may need to be reconsidered. PMID:16723571

  18. Training compliance control yields improved drawing in 5-11year old children with motor difficulties.

    PubMed

    Snapp-Childs, Winona; Shire, Katy; Hill, Liam; Mon-Williams, Mark; Bingham, Geoffrey P

    2016-08-01

    There are a large number of children with motor difficulties including those that have difficulty producing movements qualitatively well enough to improve in perceptuo-motor learning without intervention. We have developed a training method that supports active movement generation to allow improvement in a 3D tracing task requiring good compliance control. Previously, we tested a limited age range of children and found that training improved performance on the 3D tracing task and that the training transferred to a 2D drawing test. In the present study, school children (5-11years old) with motor difficulties were trained in the 3D tracing task and transfer to a 2D drawing task was tested. We used a cross-over design where half of the children received training on the 3D tracing task during the first training period and the other half of the children received training during the second training period. Given previous results, we predicted that younger children would initially show reduced performance relative to the older children, and that performance at all ages would improve with training. We also predicted that training would transfer to the 2D drawing task. However, the pre-training performance of both younger and older children was equally poor. Nevertheless, post-training performance on the 3D task was dramatically improved for both age groups and the training transferred to the 2D drawing task. Overall, this work contributes to a growing body of literature that demonstrates relatively preserved motor learning in children with motor difficulties and further demonstrates the importance of games in therapeutic interventions. PMID:27219739

  19. Cardiovascular responses to active and passive cycling movements.

    PubMed

    Nóbrega, A C; Williamson, J W; Friedman, D B; Araújo, C G; Mitchell, J H

    1994-06-01

    Ten healthy subjects were evaluated at rest and at 5 min of unloaded active (AC) and passive (PC) cycling. Passive limb movements were accomplished using a tandem bicycle with a second rider performing the movements. We measured heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), oxygen uptake (VO2), rating of perceived exertion (RPE), and electrical activity (EMG) of lower limbs muscles. Values for stroke volume (SV) and peripheral vascular resistance (PVR) were calculated. EMG, RPE, and VO2 were higher during AC than during PC (P < 0.001). CO increased during both modes of cycling, but during AC it resulted from a HR acceleration (73 +/- 2 at rest to 82 +/- 2 beats.min-1 at 60 rpm; P < 0.001) with no change in SV whereas during PC, SV increased from rest (65 +/- 4 at rest to 71 +/- 3 ml at 60 rpm; P = 0.003) along with no change in HR. PVR remained constant during PC, but decreased by 13% during AC (P < 0.001) and MAP increased only during PC (93 +/- 2 at rest to 107 +/- 2 mm Hg at 60 rpm). These results supports the concept that central command determines the HR response to dynamic exercise. The increase in SV and consequently in MAP during PC was probably due to increased venous return and/or to muscle mechanoreceptor-evoked increased myocardial contractility. PMID:8052111

  20. Chromospheric and coronal variation across stellar activity cycles

    NASA Astrophysics Data System (ADS)

    Hagen, Cedric; Miller, Brendan P.; Gallo, Elena; Wright, Jason; Isaacson, Howard T.; Henry, Gregory W.

    2015-01-01

    We investigate cyclic chromospheric and coronal activity in main-sequence stars, using Ca II H and K core emission and X-ray luminosities, respectively. From a sample of 244 nearby stars with high-cadence Keck optical spectroscopy spanning up to 17 years (obtained for the California Planet Search program), we use automated sinusoid modeling and goodness-of-fit criteria to identify 33 stars with highly significant cyclic R'HK variability. The cycle periods are refined using mmag APT optical photometry. We also construct a comparison sample of 23 stars that show virtually no R'HK variability. The cyclic and flat stars have similar B-V and absolute magnitude distributions but the cyclic stars tend to be more active, with greater median R'HK values. We present new Swift/XRT observations of 10 cyclic stars and 1 flat star, totaling 32.6 ks; 5/11 are detected in this snapshot pilot survey. A comparison of their current-epoch X-ray luminosities to archival ROSAT values shows variation by a factor of 2-3 is common on decade-long timescales. Several stars also show suggestive evidence for X-ray variability on much shorter timescales, perhaps related to stellar rotation and coronal inhomogeneity or to small flares. We use the chromospheric activity cycles to calculate the phase of each X-ray observation. Additional Swift observations are ongoing and with this larger dataset we will measure the typical amplitude of cyclic X-ray variation. We discuss our initial results in the context of magnetic dynamo activity and consider the implications for exoplanet atmosphere heating and evaporation.

  1. Korean 4- to 11-Year-Old Student Conceptions of Heat and Temperature

    ERIC Educational Resources Information Center

    Paik, Seoung-Hey; Cho, Boo-Kyung; Go, Young-Mi

    2007-01-01

    The aim of the present study is to shed light on the conceptions that young students have of heat and temperature, concepts that are both important in school science curricula and closely related to daily life. The subjects of the study were students from a rural district in South Korea and they ranged in age from 4 to 11 years. Interviews were…

  2. Easy Growth Experiment on Peas Stimulates Interest in Biology for 10-11 Year Old Pupils

    ERIC Educational Resources Information Center

    McEwen, Birgitta

    2007-01-01

    How do we support the enthusiasm children show for biology in school? Unfortunately, lack of exciting practical work and boring biology lessons seem to make science less popular. As a senior lecturer in plant physiology at Karlstad University I have simplified experiments intended for students at university and then tested them on 10-11 year old…

  3. Race and Ethnicity: An 11-Year Content Analysis of "Counseling and Values"

    ERIC Educational Resources Information Center

    Baker, Caroline A.; Bowen, Nikol V.; Butler, J. Yasmine; Shavers, Marjorie C.

    2013-01-01

    Using the Dimensions of Personal Identity Model proposed by Arredondo and Glauner (as cited in Arredondo et al., 1996), the authors reviewed the last 11 years of the Association for Spiritual, Ethical, and Religious Values in Counseling's journal, "Counseling and Values", specifically regarding the "A" dimensions of race and ethnicity. Twenty-five…

  4. Duration, Distance, and Speed Judgments of Two Moving Objects by 4- to 11-Year-Olds.

    ERIC Educational Resources Information Center

    Matsuda, Fumiko

    1996-01-01

    Four- to 11-year-olds made duration, distance, and speed judgments on Piagetian tasks where cars ran on parallel tracks. Among younger children, duration and distance judgments had approximately the same difficulty. Among older children, distance judgments were easier than duration judgments, and symmetry of effects of temporal and spatial…

  5. Basic Facts about Low-Income Children: Children 6 through 11 Years, 2013. Fact Sheet

    ERIC Educational Resources Information Center

    Jiang, Yang; Ekono, Mercedes; Skinner, Curtis

    2015-01-01

    Children under 18 years represent 23 percent of the population, but they comprise 33 percent of all people in poverty. Among all children, 44 percent live in low-income families and approximately one in every five (22 percent) live in poor families. Similarly, among children in middle childhood (age 6 through 11 years), 45 percent live in…

  6. Developing Number Knowledge: Assessment, Teaching and Intervention with 7-11 Year Olds. Math Recovery

    ERIC Educational Resources Information Center

    Wright, Robert J.; Ellemor-Collins, David; Tabor, Pamela D.

    2011-01-01

    This fourth book in the Mathematics Recovery series equips teachers with detailed pedagogical knowledge and resources for teaching number to 7 to 11-year olds. Drawing on extensive programs of research, curriculum development, and teacher development, the book offers a coherent, up-to-date approach emphasizing computational fluency and the…

  7. Psychiatric Disorders in Extremely Preterm Children: Longitudinal Finding at Age 11 Years in the EPICure Study

    ERIC Educational Resources Information Center

    Johnson, Samantha; Hollis, Chris; Kochhar, Puja; Hennessy, Enid; Wolke, Dieter; Marlow, Neil

    2010-01-01

    Objective: To investigate the prevalence and risk factors for psychiatric disorders in extremely preterm children. Method: All babies born less than 26 weeks gestation in the United Kingdom and Ireland from March through December 1995 were recruited to the EPICure Study. Of 307 survivors at 11 years of age, 219 (71%) were assessed alongside 153…

  8. Dermatitis rhabditidosa in an 11-year-old girl: a new cutaneous parasitic disease of man.

    PubMed

    Pasyk, K

    1978-01-01

    Rhabditiform larvae of Rhabditis (Pelodera) strongyloides caused pruritic lesions in an 11-year-old girl, and persisted for 2 1/2 months. Larvae were found in skin scrapings from the child and in the family dog's hair. PMID:564202

  9. Meaning-Making with Colour in Multimodal Texts: An 11-Year-Old Student's Purposeful "Doing"

    ERIC Educational Resources Information Center

    Pantaleo, Sylvia

    2012-01-01

    Colour, a visual element of art and design, is a semiotic mode that is used strategically by sign-makers to communicate meaning. Understanding the meaning-making potential of colour can enhance students' understanding, appreciation, interpretation and composition of multimodal texts. This article features a case study of Anya, an 11-year-old…

  10. The Relationship among 100% Juice Consumption, Nutrient Intake, and Weight of Children 2-11 Years

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Inconsistent research findings have led to continued debate over the potential associations between 100% juice consumption (JC), nutrient intake,and weight in children. The objective is to investigate the associations between JC, nutrient intake, and weight in children. Children 2 to 11 years of a...

  11. Position of the American Dietetic Association: Nutrition Guidance for Health Children Ages 2 to 11 Years

    Technology Transfer Automated Retrieval System (TEKTRAN)

    It is the position of the American Dietetic Association that children ages 2 to 11 years should achieve optimal physical and cognitive development, attain a healthy weight, enjoy food, and reduce the risk of chronic disease through appropriate eating habits and participation in regular physical acti...

  12. Losing Our Way? The Downward Path for Outdoor Learning for Children Aged 2-11 Years

    ERIC Educational Resources Information Center

    Waite, Sue

    2010-01-01

    This paper draws on three related empirical studies in the South West of England: a survey of outdoor experiential learning opportunities, examining attitudes, practice and aspirations of practitioners and children in educational and care settings for children between 2-11 years within a rural county; a follow-up series of five case studies; and…

  13. The Sequence of Learning Cycle Activities in High School Chemistry.

    ERIC Educational Resources Information Center

    Abraham, Michael R.; Renner, John W.

    1986-01-01

    Different learning cycle sequences were investigated to determine factors accounting for success of the cycle, compared learning with conventional instruction, and examined relationships between Piaget's theory and learning cycles. Results show that the normal learning cycle sequence is the optimum sequence for achievement of content knowledge in…

  14. Effects of Low Activity Solar Cycle on Orbital Debris Lifetime

    NASA Technical Reports Server (NTRS)

    Cable, Samual B.; Sutton, Eric K.; Lin, chin S.; Liou, J.-C.

    2011-01-01

    Long duration of low solar activity in the last solar minimum has an undesirable consequence of extending the lifetime of orbital debris. The AFRL TacSat-2 satellite decommissioned in 2008 has finally re-entered into the atmosphere on February 5th after more than one year overdue. Concerning its demise we have monitored its orbital decay and monthly forecasted Tacsat-2 re-entry since September 2010 by using the Orbital Element Prediction (OEP) model developed by the AFRL Orbital Drag Environment program. The model combines estimates of future solar activity with neutral density models, drag coefficient models, and an orbit propagator to predict satellite lifetime. We run the OEP model with solar indices forecast by the NASA Marshall Solar Activity Future Estimation model, and neutral density forecast by the MSIS-00 neutral density model. Based on the two line elements in 2010 up to mid September, we estimated at a 50% confidence level TacSat-2's re-entry time to be in early February 2011, which turned out to be in good agreement with Tacsat-2's actual re-entry date. The potential space weather effects of the coming low activity solar cycle on satellite lifetime and orbital debris population are examined. The NASA long-term orbital debris evolutionary model, LEGEND, is used to quantify the effects of solar flux on the orbital debris population in the 200-600 km altitude environment. The results are discussed for developing satellite orbital drag application product.

  15. Genipin as a novel chemical activator of EBV lytic cycle.

    PubMed

    Son, Myoungki; Lee, Minjung; Ryu, Eunhyun; Moon, Aree; Jeong, Choon-Sik; Jung, Yong Woo; Park, Gyu Hwan; Sung, Gi-Ho; Cho, Hyosun; Kang, Hyojeung

    2015-02-01

    Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt's lymphoma, nasopharyngeal and gastric carcinoma. Antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. Most antiviral agents affect actively replicating viruses, but not their latent forms. Novel antiviral agents must be active on both the replicating and the latent forms of the virus. Gardenia jasminoides is an evergreen flowering plant belonging to the Rubiaceae family and is most commonly found growing wild in Vietnam, Southern China, Taiwan, Japan, Myanmar, and India. Genipin is an aglycone derived from an iridoid glycoside called geniposide, which is present in large quantities in the fruit of G. jasminoides. In this study, genipin was evaluated for its role as an antitumor and antiviral agent that produces inhibitory effects against EBV and EBV associated gastric carcinoma (EBVaGC). In SNU719 cells, one of EBVaGCs, genipin caused significant cytotoxicity (70 μM), induced methylation on EBV C promoter and tumor suppressor gene BCL7A, arrested cell-cycle progress (S phases), upregulated EBV latent/lytic genes in a dose-dependent manner, stimulated EBV progeny production, activated EBV F promoter for EBV lytic activation, and suppressed EBV infection. These results indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC. PMID:25626372

  16. Global changes in biogeochemical cycles in response to human activities

    NASA Technical Reports Server (NTRS)

    Moore, Berrien, III; Melillo, Jerry

    1994-01-01

    The main objective of our research was to characterize biogeochemical cycles at continental and global scales in both terrestrial and aquatic ecosystems. This characterization applied to both natural ecosystems and those disturbed by human activity. The primary elements of interest were carbon and nitrogen and the analysis sought to quantify standing stocks and dynamic cycling processes. The translocation of major nutrients from the terrestrial landscape to the atmosphere (via trace gases) and to fluvial systems (via leaching, erosional losses, and point source pollution) were of particular importance to this study. Our aim was to develop the first generation of Earth System Models. Our research was organized around the construction and testing of component biogeochemical models which treated terrestrial ecosystem processes, aquatic nutrient transport through drainage basins, and trace gas exchanges at the continental and global scale. A suite of three complementary models were defined within this construct. The models were organized to operate at a 1/2 degree latitude by longitude level of spatial resolution and to execute at a monthly time step. This discretization afforded us the opportunity to understand the dynamics of the biosphere down to subregional scales, while simultaneously placing these dynamics into a global context.

  17. Residential construction demonstration project, Cycle II: Active ventilation

    SciTech Connect

    Not Available

    1991-01-01

    This report documents the analysis of the performance of natural and mechanical ventilation in Pacific Northwest homes. The analysis was part of Cycle II of the Residential Construction Demonstration Project, sponsored by Bonneville Power Administration (BPA). Since 1986, the Residential Construction Demonstration Project (RCDP) has sponsored the collection of data on energy efficient homes in the Pacific Northwest that comply with these new standards and requirements. Cycle II of RCDP was conducted between September 1987 and April 1990. It concentrated on energy innovations in homes built to the Super Good Cents specification. All of the test homes have electric heat and mechanical ventilation systems. Seven different types of active ventilation systems are represented in the homes. Three of these system types are equipped with heat recovery devices, and are represented in approximately a quarter of the test homes. The potential for both natural and mechanical ventilation was measured. Potential structural leakage was measured by blower door testing. Flow rate and operating time of mechanical ventilation systems were measured with flow hoods and hour meters. Actual ventilation was measured by using a passive tracer gas technique for several weeks during the heating season and at times of normal occupancy.

  18. Residential construction demonstration project, Cycle II: Active ventilation

    SciTech Connect

    Not Available

    1991-12-31

    This report documents the analysis of the performance of natural and mechanical ventilation in Pacific Northwest homes. The analysis was part of Cycle II of the Residential Construction Demonstration Project, sponsored by Bonneville Power Administration (BPA). Since 1986, the Residential Construction Demonstration Project (RCDP) has sponsored the collection of data on energy efficient homes in the Pacific Northwest that comply with these new standards and requirements. Cycle II of RCDP was conducted between September 1987 and April 1990. It concentrated on energy innovations in homes built to the Super Good Cents specification. All of the test homes have electric heat and mechanical ventilation systems. Seven different types of active ventilation systems are represented in the homes. Three of these system types are equipped with heat recovery devices, and are represented in approximately a quarter of the test homes. The potential for both natural and mechanical ventilation was measured. Potential structural leakage was measured by blower door testing. Flow rate and operating time of mechanical ventilation systems were measured with flow hoods and hour meters. Actual ventilation was measured by using a passive tracer gas technique for several weeks during the heating season and at times of normal occupancy.

  19. Diurnal cycle of convective activity over ocean in the Tropics

    NASA Astrophysics Data System (ADS)

    Hara, Masayuki; Takahashi, Hiroshi; Fujita, Mikiko

    2015-04-01

    In this study, the influence of land mass on the diurnal cycle of convective activity is analyzed. 17-year observation of Tropical Rainfall Measuring Mission (TRMM) 2A25 V7 (1998-2014) Estimated Surface Rain (ESR) is used as a precipitation data. We rasterized the ESR data into 0.1x0.1 degree mesh for each local solar time (LST) of observation. U. S. Geological Survey Global Land Cover Characterization (USGS GLCC) Version 2 data is used for determining the shoreline. As the many studies indicated, the precipitation peak time is about 3 LST over the Tropical ocean near the coastline, and about 15 LST over the Tropical land. Although the total precipitation amount strongly depends on the distance from the shoreline, The phase of the diurnal cycle over the ocean is not dependent on the distance from the nearest shoreline. We also performed a series of ideal experiments with a quasi-three dimensional domain using non-hydrostatic atmospheric model to elucidate the detailed feature of the relationship between land-sea contrast and local convection systems.

  20. Intertwined arbovirus transmission activity: reassessing the transmission cycle paradigm

    PubMed Central

    Diaz, Luis A.; Flores, Fernando S.; Quaglia, Agustín; Contigiani, Marta S.

    2013-01-01

    Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenomenon. Arboviruses are maintained by biologic transmission among vectors and hosts. Sometimes this biological transmission is specific and includes one vector and host species such as Chikungunya (CHIKV), Dengue (DENV), and urban Yellow Fever (YFV). However, most of the arboviruses are generalist and they use many vectors and hosts species. From this perspective, arboviruses are maintained through a transmission network rather than a transmission cycle. This allows us to understand the complexity and dynamics of the transmission and maintenance of arboviruses in the ecosystems. The old perspective that arboviruses are maintained in close and stable transmission cycles should be modified by a new more integrative and dynamic idea, representing the real scenario where biological interactions have a much broader representation, indicating the constant adaptability of the biological entities. PMID:23335900

  1. A New Simple Dynamo Model for Stellar Activity Cycle

    NASA Astrophysics Data System (ADS)

    Yokoi, N.; Schmitt, D.; Pipin, V.; Hamba, F.

    2016-06-01

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous flow effect on turbulence, it is shown that turbulent cross helicity (velocity–magnetic-field correlation) enters the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. This makes the present model different from the current α–Ω-type models in two main ways. First, in addition to the usual helicity (α) and turbulent magnetic diffusivity (β) effects, we consider the cross-helicity effect as a key ingredient of the dynamo process. Second, the spatiotemporal evolution of cross helicity is solved simultaneously with the mean magnetic fields. The basic scenario is as follows. In the presence of turbulent cross helicity, the toroidal field is induced by the toroidal rotation. Then, as in usual models, the α effect generates the poloidal field from the toroidal one. This induced poloidal field produces a turbulent cross helicity whose sign is opposite to the original one (negative production). With this cross helicity of the reversed sign, a reversal in field configuration starts. Eigenvalue analyses of the simplest possible model give a butterfly diagram, which confirms the above scenario and the equatorward migrations, the phase relationship between the cross helicity and magnetic fields. These results suggest that the oscillation of the turbulent cross helicity is a key for the activity cycle. The reversal of the cross helicity is not the result of the magnetic-field reversal, but the cause of the latter. This new model is expected to open up the possibility of the mean-field or turbulence closure dynamo approaches.

  2. Does age at first treatment episode make a difference in outcomes over 11 years?

    PubMed

    Chi, Felicia W; Weisner, Constance; Grella, Christine E; Hser, Yih-Ing; Moore, Charles; Mertens, Jennifer

    2014-04-01

    This study examines the associations between age at first substance use treatment entry and trajectory of outcomes over 11 years. We found significant differences in individual and treatment characteristics between adult intakes first treated during young adulthood (25 years or younger) and those first treated at an older age. Compared to their first treated older age counterparts matched on demographics and dependence type, those who entered first treatment during young adulthood had on average an earlier onset for substance use but a shorter duration between first substance use and first treatment entry; they also had worse alcohol and other drug outcomes 11 years post treatment entry. While subsequent substance use treatment and 12-step meeting attendance are important for both age groups in maintaining positive outcomes, relationships varied by age group. Findings underline the importance of different continuing care management strategies for those entering first treatment at different developmental stages. PMID:24462221

  3. FLUOR HANFORD (FH) MAKES CLEANUP A REALITY IN NEARLY 11 YEARS AT HANFORD

    SciTech Connect

    GERBER, M.S.

    2007-05-24

    For nearly 11 years, Fluor Hanford has been busy cleaning up the legacy of nuclear weapons production at one of the Department of Energy's (DOE'S) major sites in the United States. As prime nuclear waste cleanup contractor at the vast Hanford Site in southeastern Washington state, Fluor Hanford has changed the face of cleanup. Fluor beginning on October 1, 1996, Hanford Site cleanup was primarily a ''paper exercise.'' The Tri-Party Agreement, officially called the Hanford Federal Facility Agreement and Consent Order - the edict governing cleanup among the DOE, U.S. Environmental Protection Agency (EPA) and Washington state - was just seven years old. Milestones mandated in the agreement up until then had required mainly waste characterization, reporting, and planning, with actual waste remediation activities off in the future. Real work, accessing waste ''in the field'' - or more literally in huge underground tanks, decaying spent fuel POO{approx}{approx}S, groundwater, hundreds of contaminated facilities, solid waste burial grounds, and liquid waste disposal sites -began in earnest under Fluor Hanford. The fruits of labors initiated, completed and/or underway by Fluor Hanford can today be seen across the site. Spent nuclear fuel is buttoned up in secure, dry containers stored away from regional water resources, reactive plutonium scraps are packaged in approved containers, transuranic (TRU) solid waste is being retrieved from burial trenches and shipped offsite for permanent disposal, contaminated facilities are being demolished, contaminated groundwater is being pumped out of aquifers at record rates, and many other inventive solutions are being applied to Hanford's most intransigent nuclear wastes. (TRU) waste contains more than 100 nanocuries per gram, and contains isotopes higher than uranium on the Periodic Table of the Elements. (A nanocurie is one-billionth of a curie.) At the same time, Fluor Hanford has dramatically improved safety records, and cost

  4. Non-insulin-dependent diabetes and 11-year mortality in Asian Indian and Melanesian Fijians.

    PubMed

    Collins, V R; Dowse, G K; Ram, P; Cabealawa, S; Zimmet, P Z

    1996-02-01

    This study reports 11-year all-cause and cause-specific mortality rates according to baseline glucose tolerance for a population-based sample of adult Melanesian and Indian Fijians (n = 2638), first surveyed in 1980. Risk factors for all-cause and cardiovascular disease (CVD) mortality in subjects with non-insulin-dependent diabetes (NIDDM) are also described. The baseline survey included 75 g oral glucose tolerance tests, measurements of blood pressure, body mass index, and triceps skinfold, assays of plasma cholesterol and triglycerides, electrocardiograms, and details of smoking habits and physical activity. Mortality status was ascertained for 2546 subjects through surveillance of death certificates, medical records and interview of subjects (or relatives). Mortality rates were increased in diabetic men and women of both ethnic groups: relative risks compared to subjects without diabetes at baseline were 1.7 (CI:0.9-3.1) and 2.0 (1.1-3.7) in Melanesian and 4.2 (2.7-6.5), 3.2 (1.9-5.7) in Indian men and women, respectively. A large proportion of mortality among diabetic subjects was attributed to CVD (62%, 66% in Melanesian and 54%, 58% in Indian men and women, respectively). Mortality rates tended to be higher in Melanesians than Indians, except for diabetic men where Indians had higher total and cardiovascular disease rates. In contrast to non-diabetic Fijians, diabetic women of both ethnic groups lost their relative protection from coronary heart disease (CHD). Cox regressions for diabetic subjects showed age and fasting plasma glucose to be independent predictors of all-cause mortality in men, and age, body mass index (inversely) and systolic blood pressure in women, but lipid concentrations, and cigarette smoking were not related. After accounting for conventional CVD risk factors, diabetes conferred significantly increased risk of total, CVD, and CHD mortality. The mortality experience of Melanesian and Indian Fijians with NIDDM is similar to that

  5. [Acute bilateral impaired vision with central scotoma in an 11-year-old boy].

    PubMed

    Pollithy, S; Ach, T; Schaal, K B; Dithmar, S

    2012-09-01

    This article presents a case of acute bilateral impaired vision and central scotoma in an 11-year-old boy. Looking directly into a laser beam of a laser pointer for only a few seconds can cause retinal damage in the form of lesions of the retinal pigment epithelium and the photoreceptor layer, up to retinal hemorrhage. Patients often complain about impaired vision and a central scotoma of the affected eye. PMID:22740016

  6. Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up

    PubMed Central

    Dallaudière, Benjamin; Kerger, Joseph; Malghem, Jacques; Galant, Christine

    2015-01-01

    Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children. We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years. We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome. PMID:25793108

  7. Exercise, physical activity, and exertion over the business cycle.

    PubMed

    Colman, Gregory; Dave, Dhaval

    2013-09-01

    Shifts in time and income constraints over economic expansions and contractions would be expected to affect individuals' behaviors. We explore the impact of the business cycle on individuals' exercise, time use, and total physical exertion, utilizing information on 112,000 individual records from the 2003-2010 American Time Use Surveys. In doing so, we test a key causal link that has been hypothesized in the relation between unemployment and health, but not heretofore assessed. Using more precise measures of exercise (and other activities) than previous studies, we find that as work-time decreases during a recession, recreational exercise, TV-watching, sleeping, childcare, and housework increase. This, however, does not compensate for the decrease in work-related exertion due to job-loss, and total physical exertion declines. These effects are strongest among low-educated men, which is validating given that employment in the Great Recession has declined most within manufacturing, mining, and construction. We also find evidence of intra-household spillover effects, wherein individuals respond to shifts in spousal employment conditional on their own labor supply. The decrease in total physical activity during recessions is especially problematic for vulnerable populations concentrated in boom-and-bust industries, and may have longer-term effects on obesity and related health outcomes. PMID:23906116

  8. Long-Range Solar Activity Predictions: A Reprieve from Cycle #24's Activity

    NASA Technical Reports Server (NTRS)

    Richon, K.; Schatten, K.

    2003-01-01

    We discuss the field of long-range solar activity predictions and provide an outlook into future solar activity. Orbital predictions for satellites in Low Earth Orbit (LEO) depend strongly on exospheric densities. Solar activity forecasting is important in this regard, as the solar ultra-violet (UV) and extreme ultraviolet (EUV) radiations inflate the upper atmospheric layers of the Earth, forming the exosphere in which satellites orbit. Rather than concentrate on statistical, or numerical methods, we utilize a class of techniques (precursor methods) which is founded in physical theory. The geomagnetic precursor method was originally developed by the Russian geophysicist, Ohl, using geomagnetic observations to predict future solar activity. It was later extended to solar observations, and placed within the context of physical theory, namely the workings of the Sun s Babcock dynamo. We later expanded the prediction methods with a SOlar Dynamo Amplitude (SODA) index. The SODA index is a measure of the buried solar magnetic flux, using toroidal and poloidal field components. It allows one to predict future solar activity during any phase of the solar cycle, whereas previously, one was restricted to making predictions only at solar minimum. We are encouraged that solar cycle #23's behavior fell closely along our predicted curve, peaking near 192, comparable to the Schatten, Myers and Sofia (1996) forecast of 182+/-30. Cycle #23 extends from 1996 through approximately 2006 or 2007, with cycle #24 starting thereafter. We discuss the current forecast of solar cycle #24, (2006-2016), with a predicted smoothed F10.7 radio flux of 142+/-28 (1-sigma errors). This, we believe, represents a reprieve, in terms of reduced fuel costs, etc., for new satellites to be launched or old satellites (requiring reboosting) which have been placed in LEO. By monitoring the Sun s most deeply rooted magnetic fields; long-range solar activity can be predicted. Although a degree of uncertainty

  9. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation.

    PubMed

    Aram, Lior; Braun, Tslil; Braverman, Carmel; Kaplan, Yosef; Ravid, Liat; Levin-Zaidman, Smadar; Arama, Eli

    2016-04-01

    How cells avoid excessive caspase activity and unwanted cell death during apoptotic caspase-mediated removal of large cellular structures is poorly understood. We investigate caspase-mediated extrusion of spermatid cytoplasmic contents in Drosophila during spermatid individualization. We show that a Krebs cycle component, the ATP-specific form of the succinyl-CoA synthetase β subunit (A-Sβ), binds to and activates the Cullin-3-based ubiquitin ligase (CRL3) complex required for caspase activation in spermatids. In vitro and in vivo evidence suggests that this interaction occurs on the mitochondrial surface, thereby limiting the source of CRL3 complex activation to the vicinity of this organelle and reducing the potential rate of caspase activation by at least 60%. Domain swapping between A-Sβ and the GTP-specific SCSβ (G-Sβ), which functions redundantly in the Krebs cycle, show that the metabolic and structural roles of A-Sβ in spermatids can be uncoupled, highlighting a moonlighting function of this Krebs cycle component in CRL activation. PMID:27052834

  10. Position of the Academy of Nutrition and Dietetics: nutrition guidance for healthy children ages 2 to 11 years.

    PubMed

    Ogata, Beth N; Hayes, Dayle

    2014-08-01

    It is the position of the Academy of Nutrition and Dietetics that children ages 2 to 11 years should achieve optimal physical and cognitive development, maintain healthy weights, enjoy food, and reduce the risk of chronic disease through appropriate eating habits and participation in regular physical activity. Rapid increases in the prevalence of childhood obesity during the 1980s and 1990s focused attention on young children's overconsumption of energy-dense, nutrient-poor foods and beverages and lack of physical activity. While recent data suggest a stabilization of obesity rates, several public health concerns remain. These include the most effective ways to promote healthy weights, the number of children living in food insecurity, the under-consumption of key nutrients, and the early development of diet-related risks for chronic diseases, such as cardiovascular disease, type 2 diabetes, cancer, obesity, and osteoporosis. This Position Paper reviews what children 2 to 11 years old in the United States are reportedly eating, explores trends in food and nutrient intakes, and examines the impact of federal nutrition programs on child nutrition. Current dietary recommendations and guidelines for physical activity are also discussed. The roles of parents and caregivers in influencing the development of life-long healthy eating behaviors are highlighted. The Academy of Nutrition and Dietetics works with other allied health and food industry professionals to translate dietary recommendations and guidelines into positive, practical health messages. Specific recommendations and sources of science-based nutrition messages to improve the nutritional well-being of children are provided for food and nutrition practitioners. PMID:25060139

  11. A Summary of Closed Brayton Cycle Development Activities at NASA

    NASA Technical Reports Server (NTRS)

    Mason, Lee S.

    2009-01-01

    NASA has been involved in the development of Closed Brayton Cycle (CBC) power conversion technology since the 1960's. CBC systems can be coupled to reactor, isotope, or solar heat sources and offer the potential for high efficiency, long life, and scalability to high power. In the 1960's and 1970's, NASA and industry developed the 10 kW Brayton Rotating Unit (BRU) and the 2 kW mini-BRU demonstrating technical feasibility and performance, In the 1980's, a 25 kW CBC Solar Dynamic (SD) power system option was developed for Space Station Freedom and the technology was demonstrated in the 1990's as part of the 2 kW SO Ground Test Demonstration (GTD). Since the early 2000's, NASA has been pursuing CBC technology for space reactor applications. Before it was cancelled, the Jupiter Icy Moons Orbiter (HMO) mission was considering a 100 kWclass CBC system coupled to a gas-cooled fission reactor. Currently, CBC technology is being explored for Fission Surface Power (FSP) systems to provide base power on the moon and Mars. These recent activities have resulted in several CBC-related technology development projects including a 50 kW Alternator Test Unit, a 20 kW Dual Brayton Test Loop, a 2 kW Direct Drive Gas Brayton Test Loop, and a 12 kW FSP Power Conversion Unit design.

  12. Quantifying promoter activity during the developmental cycle of Chlamydia trachomatis

    PubMed Central

    Cong, Yanguang; Gao, Leiqiong; Zhang, Yan; Xian, Yuqi; Hua, Ziyu; Elaasar, Hiba; Shen, Li

    2016-01-01

    Chlamydia trachomatis is an important human pathogen that undergoes a characteristic development cycle correlating with stage-specific gene expression profiles. Taking advantage of recent developments in the genetic transformation in C. trachomatis, we constructed a versatile green fluorescent protein (GFP) reporter system to study the development-dependent function of C. trachomatis promoters in an attempt to elucidate the mechanism that controls C. trachomatis adaptability. We validated the use of the GFP reporter system by visualizing the activity of an early euo gene promoter. Additionally, we uncovered a new ompA promoter, which we named P3, utilizing the GFP reporter system combined with 5′ rapid amplification of cDNA ends (RACE), in vitro transcription assays, real-time quantitative RT-PCR (RT-qPCR), and flow cytometry. Mutagenesis of the P3 region verifies that P3 is a new class of C. trachomatis σ66-dependent promoter, which requires an extended −10 TGn motif for transcription. These results corroborate complex developmentally controlled ompA expression in C. trachomatis. The exploitation of genetically labeled C. trachomatis organisms with P3-driven GFP allows for the observation of changes in ompA expression in response to developmental signals. The results of this study could be used to complement previous findings and to advance understanding of C. trachomatis genetic expression. PMID:27263495

  13. Quantifying promoter activity during the developmental cycle of Chlamydia trachomatis.

    PubMed

    Cong, Yanguang; Gao, Leiqiong; Zhang, Yan; Xian, Yuqi; Hua, Ziyu; Elaasar, Hiba; Shen, Li

    2016-01-01

    Chlamydia trachomatis is an important human pathogen that undergoes a characteristic development cycle correlating with stage-specific gene expression profiles. Taking advantage of recent developments in the genetic transformation in C. trachomatis, we constructed a versatile green fluorescent protein (GFP) reporter system to study the development-dependent function of C. trachomatis promoters in an attempt to elucidate the mechanism that controls C. trachomatis adaptability. We validated the use of the GFP reporter system by visualizing the activity of an early euo gene promoter. Additionally, we uncovered a new ompA promoter, which we named P3, utilizing the GFP reporter system combined with 5' rapid amplification of cDNA ends (RACE), in vitro transcription assays, real-time quantitative RT-PCR (RT-qPCR), and flow cytometry. Mutagenesis of the P3 region verifies that P3 is a new class of C. trachomatis σ(66)-dependent promoter, which requires an extended -10 TGn motif for transcription. These results corroborate complex developmentally controlled ompA expression in C. trachomatis. The exploitation of genetically labeled C. trachomatis organisms with P3-driven GFP allows for the observation of changes in ompA expression in response to developmental signals. The results of this study could be used to complement previous findings and to advance understanding of C. trachomatis genetic expression. PMID:27263495

  14. A Solar Cycle Dependence of Nonlinearity in Magnetospheric Activity

    SciTech Connect

    Johnson, Jay R; Wing, Simon

    2005-03-08

    The nonlinear dependencies inherent to the historical K(sub)p data stream (1932-2003) are examined using mutual information and cumulant based cost as discriminating statistics. The discriminating statistics are compared with surrogate data streams that are constructed using the corrected amplitude adjustment Fourier transform (CAAFT) method and capture the linear properties of the original K(sub)p data. Differences are regularly seen in the discriminating statistics a few years prior to solar minima, while no differences are apparent at the time of solar maximum. These results suggest that the dynamics of the magnetosphere tend to be more linear at solar maximum than at solar minimum. The strong nonlinear dependencies tend to peak on a timescale around 40-50 hours and are statistically significant up to one week. Because the solar wind driver variables, VB(sub)s and dynamical pressure exhibit a much shorter decorrelation time for nonlinearities, the results seem to indicate that the nonlinearity is related to internal magnetospheric dynamics. Moreover, the timescales for the nonlinearity seem to be on the same order as that for storm/ring current relaxation. We suggest that the strong solar wind driving that occurs around solar maximum dominates the magnetospheric dynamics suppressing the internal magnetospheric nonlinearity. On the other hand, in the descending phase of the solar cycle just prior to solar minimum, when magnetospheric activity is weaker, the dynamics exhibit a significant nonlinear internal magnetospheric response that may be related to increased solar wind speed.

  15. An 11-year-old girl presenting with chronic knee pain: a case report with diagnostic dilemma.

    PubMed

    Maj, M Kamal; Ar, Abdul Halim; Faisal, Syed A; Ahmad, Johan; Das, Srijit

    2010-01-01

    Discoid meniscus is the commonest anatomical aberration of the knee joint, among rare cases such as bilateral separated lateral meniscus, accessory lateral meniscus, partial deficiency of the lateral meniscus and double-layered lateral meniscus. An 11-year-old girl presented with history of chronic pain in her right knee for the last 6 months. The problem disturbed her involvement in the sport activities at school. Clinical examination revealed a clicking sensation on knee extension with lateral joint line tenderness. Magnetic resonance imaging (MRI) of her right knee showed torn posterior horn of lateral meniscus. Arthroscopy examination revealed a discoid meniscus with absence posterior horn. Posterior horn deficient discoid meniscus is a rare form of a congenital meniscus anomaly. We as clinicians believe that the abnormal shaped meniscus may pose a diagnostic challenge clinically and radiologically. Presentation of this case may be beneficial for orthopaedicians in their daily clinical practice. PMID:21400986

  16. Solar Activity in Cycle 24 - What do Acoustic Oscillations tell us?

    NASA Astrophysics Data System (ADS)

    Jain, Kiran; Tripathy, Sushant; Simoniello, Rosaria; Hill, Frank

    2016-05-01

    Solar Cycle 24 is the weakest cycle in modern era of space- and ground-based observations. The number of sunspots visible on solar disk and other measures of magnetic activity have significantly decreased from the last cycle. It was also preceeded by an extended phase of low activity, a period that raised questions on our understanding of the solar activity cycle and its origin. This unusual behavior was not only limited to the visible features in Sun's atmosphere, the helioseismic observations also revealed peculiar behavior in the interior. It was suggested that the changes in magnetic activity were confined to shallower layers only, as a result low-degree mode frequencies were found to be anti-correlated with solar activity. Here we present results on the progression of Cycle 24 by analyzing the uninterrupted helioseismic data from GONG and SDO/HMI, and discuss differences and similarity between cycles 23 and 24 in relation to the solar activity.

  17. An international comparison of dietary patterns in 9–11-year-old children

    PubMed Central

    Mikkilä, V; Vepsäläinen, H; Saloheimo, T; Gonzalez, S A; Meisel, J D; Hu, G; Champagne, C M; Chaput, J-P; Church, T S; Katzmarzyk, P T; Kuriyan, R; Kurpad, A; Lambert, E V; Maher, C; Maia, J; Matsudo, V; Olds, T; Onywera, V; Sarmiento, O L; Standage, M; Tremblay, M S; Tudor-Locke, C; Zhao, P; Fogelholm, M

    2015-01-01

    OBJECTIVES: Dietary pattern is defined as a combination of foods and drinks and the frequency of consumption within a population. Dietary patterns are changing on a global level, which may be linked to an increased incidence of chronic diseases. The aim of this study was to identify and compare the dietary patterns among 9–11-year-old children living in urban regions in different parts of the world. METHODS: Participants were 7199 children (54% girls), aged 9–11 years, from 12 countries situated in all major world regions. Food consumption was assessed using a 23-item Food Frequency Questionnaire (FFQ). To identify dietary patterns, principal components analyses (PCA) were carried out using weekly portions as input variables. RESULTS: Both site-specific and pooled PCA resulted in two strong components. Component 1 (‘unhealthy diet pattern') included fast foods, ice cream, fried food, French fries, potato chips, cakes and sugar-sweetened sodas with >0.6 loadings. The loadings for component 2 (‘healthy diet pattern') were slightly weaker with only dark-green vegetables, orange vegetables, vegetables in general, and fruits and berries reaching a >0.6 loading. The site-specific diet pattern scores had very strong correlations with the pattern scores from the pooled data: r=0.82 and 0.94 for components 1 and 2, respectively. CONCULSIONS: The results suggest that the same ‘healthier' and ‘unhealthier' foods tend to be consumed in similar combinations among 9–11-year-old children in different countries, despite variation in food culture, geographical location, ethnic background and economic development. PMID:27152179

  18. Toxic interaction between fluvoxamine and sustained release theophylline in an 11-year-old boy.

    PubMed

    Sperber, A D

    1991-01-01

    An 11-year-old boy with asthma had been receiving a controlled release theophylline preparation. He was prescribed fluvoxamine for a depressive disorder and within a week complained of severe headaches, tiredness and vomiting. His serum theophylline concentration had increased from 14.2 mg/L (shortly before fluvoxamine was started) to 27.4 mg/L. Fluvoxamine was withdrawn and theophylline concentrations decreased. Clomipramine was substituted for fluvoxamine with no further problems, and a later theophylline concentration was 13.7 mg/L. Competitive inhibition of hepatic microsomal enzymes by fluvoxamine may have been responsible for the elevated theophylline concentrations and toxicity observed in this case. PMID:1793525

  19. Extrapyramidal side-effects of low-dose aripiprazole in an 11-year-old child.

    PubMed

    Mohapatra, Satyakam

    2016-01-01

    Partial agonism of D2 and 5-HT1A receptors accounts for the low incidence of extrapyramidal side-effects of aripiprazole. Extrapyramidal symptoms (EPS) during treatment with therapeutical doses of aripiprazole have been reported in adults and children. To the best of our knowledge, no cases of EPS with low doses (5 mg) have been reported until now. In this article, we present an 11-year-old child who developed EPS on low doses (5 mg) aripiprazole. This case emphasizes the need for careful surveillance for the development of EPS in patients treated even with low doses of aripiprazole. PMID:26933364

  20. Enterobius granuloma: an unusual cause of omental mass in an 11-year-old girl.

    PubMed

    Kılıç, Sinan; Ekinci, Saniye; Orhan, Diclehan; Senocak, Mehmet Emin

    2014-01-01

    Enterobius vermicularis (pinworm) is the only nematode that infects humans. It is one of the most common intestinal parasites. Pinworm commonly infests the terminal ileum and colon, and does not cause severe morbidity unless ectopic infection occurs. However, granulomatous lesions caused by ectopic Enterobius vermicularis infection may lead to unusual clinical symptoms and may be misinterpreted as malignant lesions. Herein, the authors present an 11-year-old girl with pinworm infection who presented with abdominal pain and an omental mass, with special emphasis on the diagnosis and treatment. PMID:24911856

  1. Giant appendix or an appendiceal mucocele? Case report of an 11-year-old child

    PubMed Central

    Nad, Marta; Kiraly, Adrienn; Bali, Ottilia; Rashed, Adel; Vizsy, Laszlo

    2014-01-01

    We present an 11-year-old male child with an enormous appendix that was regarded as an appendiceal mucocele. The disorder is very rare and usually appears in middle aged patients. It is a clinical diagnosis. It could cause a variety of symptoms, especially, acute appendicitis and unidentified lesion in the right iliac fossa. According to the reasons, it could be just a curiosity without any relevancy or the sign of a malignant lesion with bad prognostic factors. The histopathological findings prove the origin. PMID:25598994

  2. Extrapyramidal side-effects of low-dose aripiprazole in an 11-year-old child

    PubMed Central

    Mohapatra, Satyakam

    2016-01-01

    Partial agonism of D2 and 5-HT1A receptors accounts for the low incidence of extrapyramidal side-effects of aripiprazole. Extrapyramidal symptoms (EPS) during treatment with therapeutical doses of aripiprazole have been reported in adults and children. To the best of our knowledge, no cases of EPS with low doses (5 mg) have been reported until now. In this article, we present an 11-year-old child who developed EPS on low doses (5 mg) aripiprazole. This case emphasizes the need for careful surveillance for the development of EPS in patients treated even with low doses of aripiprazole. PMID:26933364

  3. Sacrococcygeal fetiform teratoma altman type 1: a rare case report in a 11 year old girl.

    PubMed

    Sood, Neelam; Kamboj, Meenakshi; Chaabra, Maninder

    2013-06-01

    Fetiform teratoma (homunculus) is a rare but distinct entity, characterized by presence of more organoid differentiation than the classical teratoma but not enough to classify as fetus-in-fetu. Presence of rudimentary limbs in presence/absence of axial skeleton is often reported as an important differentiating feature. Sacrococcygeal location has been reported in a few case reports but in neonates only. This is a rare case of sacrococcygeal fetiform teratoma (Altman type 1) in an 11-year-old girl presenting as a gluteal mass. PMID:24426616

  4. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle: science behind the myth

    PubMed Central

    Sjödin, A; Hjorth, M F; Damsgaard, C T; Ritz, C; Astrup, A; Michaelsen, K F

    2015-01-01

    Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8–11 years, with more than 13 000 24-h accelerometer recordings of activity and sleep as well as 2000 measurements of different cardiometabolic risk factors, including insulin sensitivity, appetite hormones and blood pressure, during nine lunar phases. During the period around full moon, children were 5.0 and 3.2 min per day less active, slept 2.4 and 4.1 min per night longer, had 0.03 and 0.05 higher homeostatic model assessment of insulin resistance and 0.6 and 0.8 mmHg higher mean arterial blood pressure compared with days around half moon and new moon, respectively (all P ≤ 0.02). Furthermore, ghrelin was lower and leptin was higher during the period around full moon compared with days around half moon (both P < 0.001). The results suggest that physical activity rather than sleep is responsible for the metabolic alterations observed around full moon. However, we have no understanding of potential mechanisms that may mediate a potential true link between childhood behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases. PMID:25808903

  5. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle: science behind the myth.

    PubMed

    Sjödin, A; Hjorth, M F; Damsgaard, C T; Ritz, C; Astrup, A; Michaelsen, K F

    2015-04-01

    Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8-11 years, with more than 13,000 24-h accelerometer recordings of activity and sleep as well as 2000 measurements of different cardiometabolic risk factors, including insulin sensitivity, appetite hormones and blood pressure, during nine lunar phases. During the period around full moon, children were 5.0 and 3.2 min per day less active, slept 2.4 and 4.1 min per night longer, had 0.03 and 0.05 higher homeostatic model assessment of insulin resistance and 0.6 and 0.8 mmHg higher mean arterial blood pressure compared with days around half moon and new moon, respectively (all P ≤ 0.02). Furthermore, ghrelin was lower and leptin was higher during the period around full moon compared with days around half moon (both P < 0.001). The results suggest that physical activity rather than sleep is responsible for the metabolic alterations observed around full moon. However, we have no understanding of potential mechanisms that may mediate a potential true link between childhood behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases. PMID:25808903

  6. Proton activity of the Sun in current solar cycle 24

    NASA Astrophysics Data System (ADS)

    Li, Chuan; Miroshnichenko, Leonty I.; Fang, Cheng

    2015-07-01

    We present a study of seven large solar proton events in the current solar cycle 24 (from 2009 January up to the current date). They were recorded by the GOES spacecraft with the highest proton fluxes being over 200 pfu for energies >10 MeV. In situ particle measurements show that: (1) The profiles of the proton fluxes are highly dependent on the locations of their solar sources, namely flares or coronal mass ejections (CMEs), which confirms the “heliolongitude rules” associated with solar energetic particle fluxes; (2) The solar particle release (SPR) times fall in the decay phase of the flare emission, and are in accordance with the times when the CMEs travel to an average height of 7.9 solar radii; and (3) The time differences between the SPR and the flare peak are also dependent on the locations of the solar active regions. The results tend to support the scenario of proton acceleration by the CME-driven shock, even though there exists a possibility of particle acceleration at the flare site, with subsequent perpendicular diffusion of accelerated particles in the interplanetary magnetic field. We derive the integral time-of-maximum spectra of solar protons in two forms: a single power-law distribution and a power law roll-over with an exponential tail. It is found that the unique ground level enhancement that occurred in the event on 2012 May 17 displays the hardest spectrum and the largest roll-over energy which may explain why this event could extend to relativistic energies. Supported by the National Natural Science Foundation of China.

  7. Dose estimations for Iranian 11-year-old pediatric phantoms undergoing computed tomography examinations.

    PubMed

    Akhlaghi, Parisa; Miri-Hakimabad, Hashem; Rafat-Motavalli, Laleh

    2015-07-01

    In order to establish an organ and effective dose database for Iranian children undergoing computed tomography (CT) examinations, in the first step, two Iranian 11-year-old phantoms were constructed from image series obtained from CT and magnetic resonance imaging (MRI). Organ and effective doses for these phantoms were calculated for head, chest, abdomen-pelvis and chest-abdomen-pelvis (CAP) scans at tube voltages of 80, 100 and 120 kVp, and then they were compared with those of the University of Florida (UF) 11-year-old male phantom. Depth distributions of the organs and the mass of the surrounding tissues located in the beam path, which shield the internal organs, were determined for all phantoms. From the results, it was determined that the main organs of the UF phantom receive smaller doses than the two Iranian phantoms, except for the urinary bladder of the Iranian girl phantom. In addition, the relationship between the anatomical differences and the size of the dose delivered was also investigated and the discrepancies between the results were examined and justified. PMID:25972393

  8. A case of dissociative fugue and general amnesia with an 11-year follow-up.

    PubMed

    Helmes, Edward; Brown, Julie-May; Elliott, Linda

    2015-01-01

    Dissociative fugue refers to loss of personal identity, often with the associated loss of memories of events (general amnesia). Here we report on the psychological assessment of a 54-year-old woman with loss of identity and memories of 33 years of her life attributed to dissociative fugue, along with a follow-up 11 years later. Significant levels of personal injury and stress preceded the onset of the amnesia. A detailed neuropsychological assessment was completed at a university psychology clinic, with a follow-up assessment there about 11 years later with an intent to determine whether changes in her cognitive status were associated with better recall of her life and with her emotional state. Psychomotor slowing and low scores on measures of attention and both verbal and visual memory were present initially, along with significant psychological distress associated with the diagnosis of posttraumatic stress disorder. Although memories of her life had not returned by follow-up, distress had abated and memory test scores had improved. The passage of time and a better emotional state did not lead to recovery of lost memories. Contrary to expectations, performance on tests of executive functions was good on both occasions. Multiple stressful events are attributed as having a role in maintaining the loss of memories. PMID:25365262

  9. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.

    PubMed

    Ng, Oi-Wing; Chia, Adeline; Tan, Anthony T; Jadi, Ramesh S; Leong, Hoe Nam; Bertoletti, Antonio; Tan, Yee-Joo

    2016-04-12

    Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable. PMID:26954467

  10. Dose estimations for Iranian 11-year-old pediatric phantoms undergoing computed tomography examinations

    PubMed Central

    Akhlaghi, Parisa; Miri-Hakimabad, Hashem; Rafat-Motavalli, Laleh

    2015-01-01

    In order to establish an organ and effective dose database for Iranian children undergoing computed tomography (CT) examinations, in the first step, two Iranian 11-year-old phantoms were constructed from image series obtained from CT and magnetic resonance imaging (MRI). Organ and effective doses for these phantoms were calculated for head, chest, abdomen–pelvis and chest–abdomen–pelvis (CAP) scans at tube voltages of 80, 100 and 120 kVp, and then they were compared with those of the University of Florida (UF) 11-year-old male phantom. Depth distributions of the organs and the mass of the surrounding tissues located in the beam path, which shield the internal organs, were determined for all phantoms. From the results, it was determined that the main organs of the UF phantom receive smaller doses than the two Iranian phantoms, except for the urinary bladder of the Iranian girl phantom. In addition, the relationship between the anatomical differences and the size of the dose delivered was also investigated and the discrepancies between the results were examined and justified. PMID:25972393

  11. Er:YAG laser ablation: 5-11 years prospective study

    NASA Astrophysics Data System (ADS)

    Dostalova, Tatjana; Jelinkova, Helena; Nemec, Michal; Sulc, Jan; Miyagi, Mitsunobu

    2005-03-01

    The Er:YAG laser at 2940 nm has been proposed for use in dental cavity preparation and removal of carious enamel and dentin. The purpose of the present study was to determine the effect of the Er:YAG laser ablation in treating dental caries after a period from 5 to 11 years. For this study, 133 cavities were chosen, and for their reparation of it the three restorative materials were used. Baseline examination was made in the following intervals: one week, 1 year, and from 5 to 11 years after cavity preparation and placement of filling material. Clinical assessments were carried out in accordance with the US Public Health Service System. The follow-up included: the marginal ridge, marginal adaptation, anatomic form, caries, color match, cavo surface margin discoloration, surface smoothness, and postoperative sensitivity. Er:YAG laser ablation is an excellent method for treating frontal teeth, i.e., incisors, canines, premolars, and initial occlusal caries of molars. However, visual control of non-contact therapy is necessary. Er:YAG laser ablation is safe, and it strongly reduces pain. The laser treatment markedly decreases the unpleasant sound and vibration.

  12. Element Pool Changes within a Scrub-Oak Ecosystem after 11 Years of Exposure to Elevated CO2

    PubMed Central

    Duval, Benjamin D.; Dijkstra, Paul; Drake, Bert G.; Johnson, Dale W.; Ketterer, Michael E.; Megonigal, J. Patrick; Hungate, Bruce A.

    2013-01-01

    The effects of elevated CO2 on ecosystem element stocks are equivocal, in part because cumulative effects of CO2 on element pools are difficult to detect. We conducted a complete above and belowground inventory of non-nitrogen macro- and micronutrient stocks in a subtropical woodland exposed to twice-ambient CO2 concentrations for 11 years. We analyzed a suite of nutrient elements and metals important for nutrient cycling in soils to a depth of ∼2 m, in leaves and stems of the dominant oaks, in fine and coarse roots, and in litter. In conjunction with large biomass stimulation, elevated CO2 increased oak stem stocks of Na, Mg, P, K, V, Zn and Mo, and the aboveground pool of K and S. Elevated CO2 increased root pools of most elements, except Zn. CO2-stimulation of plant Ca was larger than the decline in the extractable Ca pool in soils, whereas for other elements, increased plant uptake matched the decline in the extractable pool in soil. We conclude that elevated CO2 caused a net transfer of a subset of nutrients from soil to plants, suggesting that ecosystems with a positive plant growth response under high CO2 will likely cause mobilization of elements from soil pools to plant biomass. PMID:23717607

  13. Life cycle assessment of active and passive groundwater remediation technologies

    NASA Astrophysics Data System (ADS)

    Bayer, Peter; Finkel, Michael

    2006-02-01

    Groundwater remediation technologies, such as pump-and-treat (PTS) and funnel-and-gate systems (FGS), aim at reducing locally appearing contaminations. Therefore, these methodologies are basically evaluated with respect to their capability to yield local improvements of an environmental situation, commonly neglecting that their application is also associated with secondary impacts. Life cycle assessment (LCA) represents a widely accepted method of assessing the environmental aspects and potential impacts related to a product, process or service. This study presents the set-up of a LCA framework in order to compare the secondary impacts caused by two conceptually different technologies at the site of a former manufactured gas plant in the city of Karlsruhe, Germany. As a FGS is already operating at this site, a hypothetical PTS of the same functionality is adopted. During the LCA, the remediation systems are evaluated by focusing on the main technical elements and their significance with respect to resource depletion and potential adverse effects on ecological quality, as well as on human health. Seven impact categories are distinguished to address a broad spectrum of possible environmental loads. A main point of discussion is the reliability of technical assumptions and performance predictions for the future. It is obvious that a high uncertainty exists when estimating impact specific indicator values over operation times of decades. An uncertainty analysis is conducted to include the imprecision of the underlying emission and consumption data and a scenario analysis is utilised to contrast various possible technological variants. Though the results of the study are highly site-specific, a generalised relative evaluation of potential impacts and their main sources is the principle objective rather than a discussion of the calculated absolute impacts. A crucial finding that can be applied to any other site is the central role of steel, which particularly derogates

  14. [Pulmonary tuberculosis after 11 years of observation in a patient suffering from advanced squamous lung cancer cured by radical radiotherapy--a case report].

    PubMed

    Mysiorski, Grzegorz; Marciniak, Marek; Rogowska, Danuta; Sedlaczek, Andrzej; Witkiewicz, Iwona; Tarnowska-Matusiak, Marzenna; Pankowski, Juliusz

    2003-01-01

    Advanced lung cancer is a neoplasm of a poor prognosis. The treatment may improve it to a certain degree but not satisfactory. A case of squamous- cell lung cancer, in a stage III B of TNM classification, which was by cured completely radiotherapy is described. The 11 years post-treatment observation was performed without any symptoms of recurrence. Actually patient is hospitalised due to active tuberculosis. No evidence for lung cancer was found until now. PMID:14587431

  15. Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity

    PubMed Central

    Hodille, Elisabeth; Alekseeva, Ludmila; Berkova, Nadia; Serrier, Asma; Badiou, Cedric; Gilquin, Benoit; Brun, Virginie; Vandenesch, François; Terman, David S.; Lina, Gerard

    2016-01-01

    Maintenance of an intact epithelial barrier constitutes a pivotal defense mechanism against infections. Staphylococcus aureus is a versatile pathogen that produces multiple factors including exotoxins that promote tissue alterations. The aim of the present study is to investigate the cytopathic effect of staphylococcal exotoxins SEA, SEG, SEI, SElM, SElN and SElO on the cell cycle of various human cell lines. Among all tested exotoxins only SEIO inhibited the proliferation of a broad panel of human tumor cell lines in vitro. Evaluation of a LDH release and a DNA fragmentation of host cells exposed to SEIO revealed that the toxin does not induce necrosis or apoptosis. Analysis of the DNA content of tumor cells synchronized by serum starvation after exposure to SEIO showed G0/G1 cell cycle delay. The cell cycle modulating feature of SEIO was confirmed by the flow cytometry analysis of synchronized cells exposed to supernatants of isogenic S. aureus strains wherein only supernatant of the SElO producing strain induced G0/G1 phase delay. The results of yeast-two-hybrid analysis indicated that SEIO’s potential partner is cullin-3, involved in the transition from G1 to S phase. In conclusion, we provide evidence that SEIO inhibits cell proliferation without inducing cell death, by delaying host cell entry into the G0/G1 phase of the cell cycle. We speculate that this unique cell cycle modulating feature allows SEIO producing bacteria to gain advantage by arresting the cell cycle of target cells as part of a broader invasive strategy. PMID:27148168

  16. Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity.

    PubMed

    Hodille, Elisabeth; Alekseeva, Ludmila; Berkova, Nadia; Serrier, Asma; Badiou, Cedric; Gilquin, Benoit; Brun, Virginie; Vandenesch, François; Terman, David S; Lina, Gerard

    2016-01-01

    Maintenance of an intact epithelial barrier constitutes a pivotal defense mechanism against infections. Staphylococcus aureus is a versatile pathogen that produces multiple factors including exotoxins that promote tissue alterations. The aim of the present study is to investigate the cytopathic effect of staphylococcal exotoxins SEA, SEG, SEI, SElM, SElN and SElO on the cell cycle of various human cell lines. Among all tested exotoxins only SEIO inhibited the proliferation of a broad panel of human tumor cell lines in vitro. Evaluation of a LDH release and a DNA fragmentation of host cells exposed to SEIO revealed that the toxin does not induce necrosis or apoptosis. Analysis of the DNA content of tumor cells synchronized by serum starvation after exposure to SEIO showed G0/G1 cell cycle delay. The cell cycle modulating feature of SEIO was confirmed by the flow cytometry analysis of synchronized cells exposed to supernatants of isogenic S. aureus strains wherein only supernatant of the SElO producing strain induced G0/G1 phase delay. The results of yeast-two-hybrid analysis indicated that SEIO's potential partner is cullin-3, involved in the transition from G1 to S phase. In conclusion, we provide evidence that SEIO inhibits cell proliferation without inducing cell death, by delaying host cell entry into the G0/G1 phase of the cell cycle. We speculate that this unique cell cycle modulating feature allows SEIO producing bacteria to gain advantage by arresting the cell cycle of target cells as part of a broader invasive strategy. PMID:27148168

  17. Comments on: "11-year cycle in Schumann resonance data as observed in Antarctica" by Nickolaenko et al. (2015)

    NASA Astrophysics Data System (ADS)

    Williams, E.

    2016-03-01

    Recent interpretation by Nickolaenko et al. (2015) of Schumann resonance observations in Antarctica is reviewed. Evidence from the literature suggests that certain aspects of these interpretations are flawed. Alternative interpretations are offered.

  18. Postintubation tracheal stenosis in an 11-year-old boy: a surgical and anaesthetic challenge.

    PubMed

    Aguilera, I M; Walker, R W M; Dearlove, O R

    2002-10-01

    We present a case of postintubation tracheal stenosis in an 11-year-old boy occurring after a relatively short period of intubation. He had been intubated and ventilated in a paediatric intensive care unit after a road traffic accident. Clinical symptoms manifested by oxygen desaturation and wheeziness, finally leading to deterioration of the level of consciousness, occurred a few hours after the first attempt at extubation after 48 h requiring reintubation. Endoscopic examination performed a few weeks later revealed a tracheal stenosis. Consequently, he underwent an initial period of conservative treatment consisting of balloon dilatation and intralesional injection of steroids, followed by a tracheal resection and reconstruction. The anaesthetic management of patients with tracheal stenosis presenting for laryngo-tracheobronchoscopy and balloon dilatation is discussed. PMID:12472713

  19. The Pioneer Venus Orbiter: 11 years of data. A laboratory for atmospheres seminar talk

    NASA Technical Reports Server (NTRS)

    Kasprzak, W. T.

    1990-01-01

    The Pioneer Venus Orbiter has been in operation since orbit insertion on December 4, 1978. For the past 11 years, it has been acquiring data in the salient features of the planet, its atmosphere, ionosphere, and interaction with the solar wind. A few of the results of this mission are summarized and their contribution to our general understanding of the planet Venus is discussed. Although Earth and Venus are often called twin planets, they are only superficially similar. Possessing no obvious evidence of plate tectonics, lacking water and an intrinsic magnetic field, and having a hot, dense carbon dioxide atmosphere with sulfuric acid clouds makes Venus a unique object of study by the Orbiter's instruments.

  20. Acute Ataxia in Childhood: 11-Year Experience at a Major Pediatric Neurology Referral Center.

    PubMed

    Thakkar, Kavita; Maricich, Stephen M; Alper, Gulay

    2016-08-01

    We categorized the causes of acute ataxia in the pediatric population-referred to the Division of Neurology-at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, ADEM, meningitis, cerebral vein thrombosis, Leigh's disease, Miller-Fisher syndrome, and concussion. Among the patients with post-infectious cerebellar ataxia, 85% were 1-6 years old and all had a history of antecedent viral illness. CSF pleocytosis was present in 40% of patients; all had normal brain MRIs. The majority (91%) recovered within 30 days. We conclude that post-infectious cerebellar ataxia remains the most common cause of acute ataxia in childhood and that it carries a good prognosis. We also differentiate acute post-infectious cerebellar ataxia from other causes with similar presentations. PMID:27071467

  1. An 11-year-old boy with pharyngitis and cough: Lemierre syndrome

    PubMed Central

    Mação, Patricia; Cancelinha, Candida; Lopes, Paulo; Rodrigues, Fernanda

    2013-01-01

    The authors present the case of an 11-year-old boy with pharyngitis, treated with amoxicillin, that worsened on day 7, with cough, high fever and refusal to eat. Lethargy and respiratory distress were noted. Based on radiographic findings of bilateral infiltrates he was diagnosed with pneumonia and started on intravenous ampicillin and erythromycin. Two days later he complained of right-sided neck pain and a palpable mass was identified. An ultrasound showed partial thrombosis of the right internal jugular vein and a lung CT scan revealed multiple septic embolic lesions. Lemierre syndrome was diagnosed, antibiotic treatment adjusted and anticoagulation started. A neck CT-scan showed a large parapharyngeal abscess. His clinical condition improved gradually and after 3 weeks of intravenous antibiotics he was discharged home on oral treatment. This case illustrates the importance of diagnosing Lemierre syndrome in the presence of pharyngitis with localised neck pain and respiratory distress, to prevent potentially fatal complications. PMID:23616317

  2. Performance as a function of shooting style in basketball players under 11 years of age.

    PubMed

    Arias, José L

    2012-04-01

    Shooting style in basketball refers to the height adopted by a player in holding the ball, specifically the height of the hand and the ball with regard to the line of sight before the final extension of the elbow during a shot. The literature differentiates between a high and a low style. This study analyzed shooting frequency in young boys as a function of style and which shooting style had the highest accuracy and success in real games. Participants were 81 boys from eight basketball teams, aged 9-11 years. The sample consisted of 5,740 standard shots in 56 games. The design was nomotethic, follow-up, and multidimensional. The results indicated that low style predominated over the high style, although overall accuracy and efficacy were better using the high style. Various strategies and practical considerations are suggested for teachers and coaches to focus on teaching the high style. PMID:22755449

  3. A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl.

    PubMed

    Severinski, Srećko; Butorac Ahel, Ivona; Ovuka, Aleksandar; Verbić, Arijan

    2016-08-01

    Diabetic ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycemia, metabolic acidosis and ketonuria. Cerebral edema is the most common rare complication of DKA in children. The objective of the study was to emphasize the importance of careful evaluation and monitoring for signs and symptoms of cerebral edema in all children undergoing treatment for DKA. We present a case of 11-year-old girl with a history of diabetes mellitus type I (T1DM) who presented with severe DKA complicated by hypovolemic shock, cerebral edema and hematemesis. Considering the fact that complications of DKA are rare and require a high index of clinical suspicion, early recognition and treatment are crucial for avoiding permanent damage. PMID:27226096

  4. An 11-year-old boy with Plasmodium falciparum malaria and dengue co-infection.

    PubMed

    Issaranggoon na ayuthaya, Satja; Wangjirapan, Anchalee; Oberdorfer, Peninnah

    2014-01-01

    Malaria and dengue fever are major mosquito-borne public health problems in tropical countries. The authors report a malaria and dengue co-infection in an 11-year-old boy who presented with sustained fever for 10 days. The physical examination revealed a flushed face, injected conjunctivae and left submandibular lymphadenopathy. His peripheral blood smear showed few ring-form trophozoites of Plasmodium falciparum. His blood tests were positive for dengue NS-1 antigen and IgM antibody, and negative for IgG antibody. After the initiation of antimalarial treatment with artesunate and mefloquine, his clinical condition gradually improved. However, he still had low-grade fever that persisted for 6 days. Finally, he recovered well without fluid leakage, shock or severe bleeding. This case report emphasises that early recognition and concomitant treatment of malaria and dengue co-infection in endemic areas can improve clinical outcome and prevent serious complications. PMID:24692379

  5. Pulmonary veno-occlusive disease in an 11-year-old girl: diagnostic pitfalls.

    PubMed

    Kano, Gen; Nakamura, Keiko; Sakamoto, Izumi

    2014-02-01

    Pulmonary veno-occlusive disease (PVOD) is a rare chronic lung disease that is difficult to diagnose due to non-specific clinical findings. Little is known about the pathogenesis of PVOD. Reported herein is the case of an 11-year-old girl who initially presented with 'bat-wing' shadows on chest radiography. This finding, coupled with prominent hemosiderosis in bronchoalveolar lavage fluid, initially led to a misdiagnosis of idiopathic pulmonary hemosiderosis. Oral prednisolone dramatically improved signs and symptoms initially, but her condition then gradually deteriorated during maintenance therapy with corticosteroids and other immunosuppressants. PVOD was suspected but not confirmed owing to a lack of hallmark radiographic findings and contraindications for lung biopsy. Three years later, while arranging for lung transplantation, the patient experienced sudden onset of fatal massive pulmonary edema. PVOD was confirmed at autopsy. This case provides insights regarding an unfamiliar presentation of PVOD and may help physicians to avoid diagnostic pitfalls. PMID:24548200

  6. Music listening and cognitive abilities in 10- and 11-year-olds: the blur effect.

    PubMed

    Schellenberg, E Glenn; Hallam, Susan

    2005-12-01

    The spatial abilities of a large sample of 10 and 11 year olds were tested after they listened to contemporary pop music, music composed by Mozart, or a discussion about the present experiment. After being assigned at random to one of the three listening experiences, each child completed two tests of spatial abilities. Performance on one of the tests (square completion) did not differ as a function of the listening experience, but performance on the other test (paper folding) was superior for children who listened to popular music compared to the other two groups. These findings are consistent with the view that positive benefits of music listening on cognitive abilities are most likely to be evident when the music is enjoyed by the listener. PMID:16597767

  7. Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.

    PubMed

    Zímová, Jana; Zímová, Pavlína

    2016-06-01

    Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a patient`s repetitive self-pulling of hair. The disorder is included under anxiety disorders because it shares some obsessive-compulsive features. Patients have the tendency towards feelings of unattractiveness, body dissatisfaction, and low self-esteem (1,2). It is a major psychiatric problem, but many patients with this disorder first present to a dermatologist. An 11-year-old girl came to our department with a 2-month history of diffuse hair loss on the frontoparietal and parietotemporal area (Figure 1). She had originally been examined by a pediatrician with the diagnosis of alopecia areata. The patient`s personal history included hay fever and shortsightedness, and she suffered from varicella and mononucleosis. Nobody in the family history suffered from alopecia areata, but her father has male androgenetic alopecia (Norwood/Hamilton MAGA C3F3). The mother noticed that the child had had changeable mood for about 2 months and did not want to communicate with other persons in the family. The family did not have any pet at home. At school, her favorite subjects were Math and Computer Studies. She did not like Physical Education and did not participate in any sport activities during her free time. This was very strange because she was obese (body-mass index (BMI) 24.69). She was sometimes angry with her 13-year-old sister who had better results at school. The girl had suddenly started to wear a blue scarf. The parents did not notice that she pulled out her hair at home. Dermatological examination of the capillitium found a zone of incomplete alopecia in the frontoparietal and parietotemporal area, without inflammation, desquamation, and scaring. Hairs were of variable length (Figure 1). There was a patch of incomplete alopecia above the forehead between two stripes of hair of variable length (Figure 2). The hair pull test was

  8. Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model

    PubMed Central

    Kim, Min Hyeok; Kim, Young Jin; Kim, Hee Ryung; Jeon, Tae-Joon; Choi, Jae Boong; Chung, Ka Young; Kim, Moon Ki

    2016-01-01

    Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a GDP-bound G protein heterotrimer. The G protein cycle is allosterically modulated by conformational changes of the Gα subunit. Although biochemical and biophysical methods have elucidated the structure and dynamics of Gα, the precise conformational mechanisms underlying the G protein cycle are not fully understood yet. Simulation methods could help to provide additional details to gain further insight into G protein signal transduction mechanisms. In this study, using the available X-ray crystal structures of Gα, we simulated the entire G protein cycle and described not only the steric features of the Gα structure, but also conformational changes at each step. Each reference structure in the G protein cycle was modeled as an elastic network model and subjected to normal mode analysis. Our simulation data suggests that activated receptors trigger conformational changes of the Gα subunit that are thermodynamically favorable for opening of the nucleotide-binding pocket and GDP release. Furthermore, the effects of GTP binding and hydrolysis on mobility changes of the C and N termini and switch regions are elucidated. In summary, our simulation results enabled us to provide detailed descriptions of the structural and dynamic features of the G protein cycle. PMID:27483005

  9. Performance improvement: an active life cycle product management

    NASA Astrophysics Data System (ADS)

    Cucchiella, Federica; Gastaldi, Massimo; Lenny Koh, S. C.

    2010-03-01

    The management of the supply chain has gained importance in many manufacturing firms. Operational flexibility can be considered a crucial weapon to increase competitiveness in a turbulent marketplace. It reflects the ability of a firm to properly and rapidly respond to a variable and dynamic environment. For the firm operating in a fashion sector, the management of the supply chain is even more complex because the product life cycle is shorter than that of the firm operating in a non-fashion sector. The increase of firm flexibility level can be reached through the application of the real option theory inside the firm network. In fact, real option may increase the project value by allowing managers to more efficiently direct the production. The real option application usually analysed in literature does not take into account that the demands of products are well-defined by the product life cycle. Working on a fashion sector, the life cycle pattern is even more relevant because of an expected demand that grows according to a constant rate that does not capture the demand dynamics of the underlying fashion goods. Thus, the primary research objective of this article is to develop a model useful for the management of investments in a supply chain operating in a fashion sector where the system complexity is increased by the low level of unpredictability and stability that is proper of the mood phenomenon. Moreover, unlike the traditional model, a real option framework is presented here that considers fashion product characterised by uncertain stages of the production cycle.

  10. Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription

    PubMed Central

    Banyai, Gabor; Baïdi, Feriel; Coudreuse, Damien; Szilagyi, Zsolt

    2016-01-01

    Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and requires the periodic expression of particular gene clusters in different cell cycle phases. However, the interplay between the networks that generate these transcriptional oscillations and the core cell cycle machinery remains largely unexplored. In this work, we use a synthetic regulable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity, with different clusters directly responding to specific activity levels. We further establish that cell cycle events neither participate in nor interfere with the Cdk1-driven transcriptional program, provided that cells are exposed to the appropriate Cdk1 activities. These findings contrast with current models that propose self-sustained and Cdk1-independent transcriptional oscillations. Our work therefore supports a model in which Cdk1 activity serves as a quantitative platform for coordinating cell cycle transitions with the expression of critical genes to bring about proper cell cycle progression. PMID:27045731

  11. Prediction of solar activity from solar background magnetic field variations in cycles 21-23

    SciTech Connect

    Shepherd, Simon J.; Zharkov, Sergei I.; Zharkova, Valentina V. E-mail: s.zharkov@hull.ac.uk

    2014-11-01

    A comprehensive spectral analysis of both the solar background magnetic field (SBMF) in cycles 21-23 and the sunspot magnetic field in cycle 23 reported in our recent paper showed the presence of two principal components (PCs) of SBMF having opposite polarity, e.g., originating in the northern and southern hemispheres, respectively. Over a duration of one solar cycle, both waves are found to travel with an increasing phase shift toward the northern hemisphere in odd cycles 21 and 23 and to the southern hemisphere in even cycle 22. These waves were linked to solar dynamo waves assumed to form in different layers of the solar interior. In this paper, for the first time, the PCs of SBMF in cycles 21-23 are analyzed with the symbolic regression technique using Hamiltonian principles, allowing us to uncover the underlying mathematical laws governing these complex waves in the SBMF presented by PCs and to extrapolate these PCs to cycles 24-26. The PCs predicted for cycle 24 very closely fit (with an accuracy better than 98%) the PCs derived from the SBMF observations in this cycle. This approach also predicts a strong reduction of the SBMF in cycles 25 and 26 and, thus, a reduction of the resulting solar activity. This decrease is accompanied by an increasing phase shift between the two predicted PCs (magnetic waves) in cycle 25 leading to their full separation into the opposite hemispheres in cycle 26. The variations of the modulus summary of the two PCs in SBMF reveals a remarkable resemblance to the average number of sunspots in cycles 21-24 and to predictions of reduced sunspot numbers compared to cycle 24: 80% in cycle 25 and 40% in cycle 26.

  12. Altered lower leg muscle activation patterns in patients with cerebral palsy during cycling on an ergometer

    PubMed Central

    Alves-Pinto, Ana; Blumenstein, Tobias; Turova, Varvara; Lampe, Renée

    2016-01-01

    Objective Cycling on a recumbent ergometer constitutes one of the most popular rehabilitation exercises in cerebral palsy (CP). However, no control is performed on how muscles are being used during training. Given that patients with CP present altered muscular activity patterns during cycling or walking, it is possible that an incorrect pattern of muscle activation is being promoted during rehabilitation cycling. This study investigated patterns of muscular activation during cycling on a recumbent ergometer in patients with CP and whether those patterns are determined by the degree of spasticity and of mobility. Methods Electromyographic (EMG) recordings of lower leg muscle activation during cycling on a recumbent ergometer were performed in 14 adult patients diagnosed with CP and five adult healthy participants. EMG recordings were done with an eight-channel EMG system built in the laboratory. The activity of the following muscles was recorded: Musculus rectus femoris, Musculus biceps femoris, Musculus tibialis anterior, and Musculus gastrocnemius. The degree of muscle spasticity and mobility was assessed using the Modified Ashworth Scale and the Gross Motor Function Classification System, respectively. Muscle activation patterns were described in terms of onset and duration of activation as well as duration of cocontractions. Results Muscle activation in CP was characterized by earlier onsets, longer periods of activation, a higher occurrence of agonist–antagonist cocontractions, and a more variable cycling tempo in comparison to healthy participants. The degree of altered muscle activation pattern correlated significantly with the degree of spasticity. Conclusion This study confirmed the occurrence of altered lower leg muscle activation patterns in patients with CP during cycling on a recumbent ergometer. There is a need to develop feedback systems that can inform patients and therapists of an incorrect muscle activation during cycling and support the training

  13. Reporting accuracy of packed lunch consumption among Danish 11-year-olds differ by gender

    PubMed Central

    Lyng, Nina; Fagt, Sisse; Davidsen, Michael; Hoppe, Camilla; Holstein, Bjørn; Tetens, Inge

    2013-01-01

    Background Packed lunch is the dominant lunch format in many countries including Denmark. School lunch is consumed unsupervised, and self-reported recalls are appropriate in the school setting. However, little is known about the accuracy of recalls in relation to packed lunch. Objective To assess the qualitative recall accuracy of self-reported consumption of packed lunch among Danish 11-year-old children in relation to gender and dietary assessment method. Design A cross-sectional dietary recall study of packed lunch consumption. Digital images (DIs) served as an objective reference method to determine food items consumed. Recalls were collected with a lunch recall questionnaire (LRQ) comprising an open-ended recall (OE-Q) and a pre-coded food group prompted recall (PC-Q). Individual interviews (INTs) were conducted successively. The number of food items was identified and accuracy was calculated as match rates (% identified by DIs and reported correctly) and intrusion rates (% not identified by DIs but reported) were determined. Setting and subjects Three Danish public schools from Copenhagen. A total of 114 Danish 11-year-old children, mean (SE) age=11.1 (0.03), and body mass index=18.2 (0.26). Results The reference (DIs) showed that girls consumed a higher number of food items than boys [mean (SE) 5.4 (0.25) vs. 4.6 (0.29) items (p=0.05)]. The number of food items recalled differed between genders with OE-Q recalls (p=0.005) only. Girls’ interview recalls were more accurate than boys’ with higher match rates (p=0.04) and lower intrusion rates (p=0.05). Match rates ranged from 67–90% and intrusion rates ranged from 13–39% with little differences between girls and boys using the OE-Q and PC-Q methods. Conclusion Dietary recall validation studies should not only consider match rates as an account of accuracy. Intrusions contribute to over-reporting in non-validation studies, and future studies should address recall accuracy and inaccuracies in relation to

  14. Respiratory Muscle Activity During Simultaneous Stationary Cycling and Inspiratory Muscle Training.

    PubMed

    Hellyer, Nathan J; Folsom, Ian A; Gaz, Dan V; Kakuk, Alynn C; Mack, Jessica L; Ver Mulm, Jacyln A

    2015-12-01

    Inspiratory muscle training (IMT) strengthens the muscles of respiration, improves breathing efficiency, and increases fitness. The IMT is generally performed independently of aerobic exercise; however, it is not clear whether there is added benefit of performing the IMT while simultaneously performing aerobic exercise in terms of activating and strengthening inspiratory muscles. The purpose of our study was to determine the effect of IMT on respiratory muscle electromyography (EMG) activity during stationary cycling in the upright and drops postures as compared with that when the IMT was performed alone. Diaphragm and sternocleidomastoid EMG activity was measured under different resting and cycling postures, with and without the use of the IMT at 40% maximal inspiratory pressure (n = 10; mean age 37). Cycling in an upright posture while simultaneously performing the IMT resulted in a significantly greater diaphragm EMG activity than while performing the IMT at rest in upright or drops postures (p ≤ 0.05). Cycling in drops postures while performing the IMT had a significantly greater diaphragm EMG activity than when performing the IMT at rest in either upright or drops postures (p ≤ 0.05). Sternocleidomastoid muscle activity increased with both cycling and IMT, although posture had little effect. These results support our hypothesis in that the IMT while cycling increases respiratory EMG activity to a significantly greater extent than when performing the IMT solely at rest, suggesting that the combination of IMT and cycling may provide an additive training effect. PMID:26584054

  15. The Life Cycle of Active Region Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Cheung, M. C. M.; van Driel-Gesztelyi, L.; Martínez Pillet, V.; Thompson, M. J.

    2016-08-01

    We present a contemporary view of how solar active region magnetic fields are understood to be generated, transported and dispersed. Empirical trends of active region properties that guide model development are discussed. Physical principles considered important for active region evolution are introduced and advances in modeling are reviewed.

  16. The EPICure Study: Association between Hemodynamics and Lung Function at 11 Years after Extremely Preterm Birth

    PubMed Central

    Bolton, Charlotte E.; Stocks, Janet; Hennessy, Enid; Cockcroft, John R.; Fawke, Joseph; Lum, Sooky; McEniery, Carmel M.; Wilkinson, Ian B.; Marlow, Neil

    2012-01-01

    Objective To investigate the relationship between disturbed lung function and large-artery hemodynamics in school-age children born extremely preterm (EP) (at 25 completed weeks of gestation or less). Study design This was a cross-sectional study of participants from the EPICure study, now aged 11 years (n = 66), and 86 age- and sex-matched term-born classmates. Spirometry parameters (including forced expiratory volume in 1 second), blood pressure, and augmentation index (AIx, a composite of arterial stiffness and global wave reflections) were measured. Results Compared with their classmates, the EP children had significantly impaired lung function, particularly those with neonatal bronchopulmonary dysplasia. Peripheral blood pressure did not differ significantly between the 2 groups, but AIx values were on average 5% higher (95% CI, 2%-8%) in the preterm infants, remaining significant after adjustment for potential confounders. Neonatal bronchopulmonary dysplasia status was not related to AIx. Lung function and maternal smoking were independently associated with AIx; AIx increased by 2.7% per z-score reduction in baseline forced expiratory volume in 1 second and by 4.9% in those whose mothers smoked during pregnancy. Conclusion The independent association between impaired lung function and cardiovascular physiology in early adolescence implies higher cardiovascular risk for children born EP, and suggests that prevention of chronic neonatal lung disease may be a priority in reducing later cardiovascular risk in preterm infants. PMID:22575246

  17. Spontaneous pneumomediastinum in an 11-year-old boy after a shallow breath-hold dive.

    PubMed

    Laitila, Maija; Eskola, Vesa

    2013-12-01

    Spontaneous pneumomediastinum is caused by pulmonary barotrauma due to transiently increased intra-alveolar and intra-bronchial pressure. The most frequent triggers of spontaneous pneumomediastinum in children are asthma and manoeuvres creating forced expiration. It has been rarely associated with breath-hold diving. Chest pain and dyspnoea are the main symptoms, and the diagnosis can be confirmed by chest X-ray. The treatment of choice is oxygen, analgesics and monitoring the patient. The recurrence rate is low. The main differential diagnoses of spontaneous pneumomediastinum are oesophageal perforation and pericarditis. We report a case of an 11-year-old boy with no substantial medical history, who tried to breath-hold in shallow water for as long as possible. After diving, he felt dyspnoea and chest pain. Chest X-ray revealed pneumomediastinum and subcutaneous emphysema. The patient was admitted to the PICU for observation and was discharged after two days' follow up. Spontaneous pneumomediastinum in children may be more common than thus far acknowledged. It requires a high index of suspicion and should be considered in all children with acute chest pain. PMID:24510332

  18. Hydration Deficit in 9- to 11-Year-Old Egyptian Children

    PubMed Central

    Gouda, Zaghloul; Zarea, Mohamed; El-Hennawy, Usama; Viltard, Mélanie; Lepicard, Eve; Hawili, Nasrine; Constant, Florence

    2015-01-01

    Background. Children who drink too little to meet their daily water requirements are likely to become dehydrated, and even mild dehydration can negatively affect health. This is even more important in Middle-Eastern countries where high temperatures increase the risk of dehydration. We assessed morning hydration status in a sample of 519 Egyptian schoolchildren (9-11 years old). Methods. Children completed a questionnaire on breakfast intakes and collected a urine sample after breakfast. Breakfast food and fluid nutritional composition was analyzed and urine osmolality was measured using osmometry. Results. The mean urine osmolality of children was 814 mOsmol/kg: >800 mOsmol/kg (57%) and >1000 mOsmol/kg (24.7%). Furthermore, the results showed that a total water intake of less than 400 mL was associated with a significant higher risk of dehydration. Surprisingly, 63% of the children skipped breakfast. Conclusions. The results showed that a majority of Egyptian schoolchildren arrive at school with a hydration deficit. These results highlight the fact that there is a need to educate schoolchildren about the importance of having a breakfast and adequate hydration. PMID:27335985

  19. Anemia and Iron Deficiency in Vietnamese Children, 6 to 11 Years Old.

    PubMed

    Le Nguyen Bao, Khanh; Tran Thuy, Nga; Nguyen Huu, Chinh; Khouw, Ilse; Deurenberg, Paul

    2016-07-01

    In a population sample of 385 children, 6 to 11 years old, venous blood parameters-hemoglobin (Hb), ferritin, red blood cell count (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), C-reactive protein (CRP), and α1-acid glycoprotein (AGP)-were determined to get insight into the iron status. The prevalence of anemia was 11.4%; 5.6% had iron deficiency (ID), whereas 0.4% had ID anemia. Correction for inflammation based on CRP and AGP did not markedly change the overall prevalence of ID and ID anemia. Stunted children had lower Hb and ferritin values compared with nonstunted children, and thin children had lower values compared with normal-weight or overweight and obese children. Many nonanemic children had alert values for RBC, MCV, MCH, and MCHC. It is concluded that although the prevalence of anemia is of the magnitude of a mild public health problem, the iron status of many nonanemic children is borderline, as indicated by a high number of children with low values for red blood cytology. PMID:27052301

  20. Assessment of bully/victim problems in 8 to 11 year-olds.

    PubMed

    Austin, S; Joseph, S

    1996-12-01

    The aim of the present study was to develop two six-item self-report scales (the Bullying-Behaviour Scale and the Peer-Victimisation Scale) to assess bully-victim problems at school. These scales were designed so that they could be immersed within the Self-Perception Profile for Children (SPPC: Harter, 1985) thus reducing the saliency of the items. Internal reliability of both scales was found to be satisfactory (Cronbach's alpha = 0.83 and 0.82 respectively). Data are reported on the association between scores on both scales and scores on the SPPC and the Birleson Depression Inventory (Birleson, 1981) with 425 children (204 boys and 221 girls) ranging from 8 to 11 years (mean = 9.2 years). Forty-six per cent of the children were classified as bullies, victims, or both: 22 per cent were classified as victims only, 15 per cent as bully/victims, and 9 per cent as bullies only. PMID:9008423

  1. Pneumomediastinum and Pneumopericardium in an 11-Year-Old Rugby Player: A Case Report

    PubMed Central

    Vanzo, Valentina; Bugin, Samuela; Snijders, Deborah; Bottecchia, Laura; Storer, Veronica; Barbato, Angelo

    2013-01-01

    Objective: Pneumomediastinum and pneumopericardium are rare occurrences in young athletes, but they can result in potentially life-threatening consequences. Background: While involved in a rugby match, an 11-year-old boy received a chest compression by 3 players during a tackle. He continued to play, but 2 hours later, he developed sharp retrosternal chest pain. A chest radiograph and an echocardiograph at the nearest emergency department showed pneumopericardium and pneumomediastinum. Differential Diagnosis: Sternal and rib contusions, rib fractures, heartburn, acute asthma exacerbation, pneumomediastinum, pneumopericardium, pneumothorax, traumatic tracheal rupture, myocardial infarction, and costochondritis (Tietze syndrome). Treatment: Acetaminophen for pain control. Uniqueness: To our knowledge, this is the only case in the international literature of the simultaneous occurrence of pneumomediastinum and pneumopericardium in a child as a consequence of blunt chest trauma during a rugby match. Conclusions: Pneumomediastinum and pneumopericardium may be consequences of rugby blunt chest trauma. Symptoms can appear 1 to 2 hours later, and the conditions may result in serious complications. Immediate admission to the emergency department is required. PMID:23672393

  2. Hypohydrotic ectodermal dysplasia: an unusual presentation and management in an 11-year-old Xhosa boy.

    PubMed

    Sarvan, I; Naidoo, S; Norval, E J

    2000-01-01

    Ectodermal dysplasia (ED) is an inherited disorder in which two or more ectodermally derived structures fail to develop, or are abnormal in development. Hypohydrotic ectodermal dysplasia (HED) or Christ-Siemens-Touraine syndrome, is an X-linked recessive syndrome with an incidence of 1/10,000 to 1/100,000 births. Because of its X-linked inheritance pattern, it is more common in males. HED is characterised by hypohydrosis (diminished perspiration), hypotrichosis (decreased amount of hair) and microdontia (small teeth), hypodontia (lack of development of one or more teeth) or adontia (total lack of tooth development). These patients present diagnostic and treatment challenges because of variable oral manifestations. This report describes an 11-year-old Xhosa boy, who was referred to the University Dental Faculty by his general medical practitioner because of hypodontia. General facial features included: frontal bossing, a depressed nasal bridge, 'butterfly' pattern of eczema over the nasal bridge to the malar process of each cheek, thinned out hair, loss of vertical dimension of face and dry skin. Intra-oral examination revealed hypodontia with peg-shaped anterior teeth and diastemas. Radiological examination revealed no developing permanent teeth or tooth buds. Diagnosis was confirmed by doing a sweat gland count. Management included oral hygiene instruction, fluoride treatments, construction of a partial lower denture and counselling about his condition with particular reference to the danger of hyperthermia and control of allergies. PMID:12608250

  3. Diagnosis and Treatment of Odontogenic Cutaneous Sinus Tracts in an 11-Year-Old Boy

    PubMed Central

    Chen, Ke; Liang, Yun; Xiong, Huacui

    2016-01-01

    Abstract Odontogenic cutaneous sinus tracts (OCSTs) are generally primarily misdiagnosed and inappropriately treated by virtue of their rarity and the absence of dental symptoms. Accurate diagnosis and treatment and the elimination of the source of infection can reduce the incidence of complications and relieve the pain of the patient. In this case report, we present the case of an 11-year-old patient with an apparent abscess but an unobvious draining sinus tract in his left cheek. Intraorally, a glass-ionomer-cement filling on the occlusal surface of the left mandibular first molar (tooth 36) was noted. Radiographic examination revealed a radiopaque mass inside the crown and pulp chamber and an irregular, radiolucent periapical lesion surrounding the distal root apex. He was diagnosed with an OCTS secondary to a periapical abscess of tooth 36. Precise root canal therapy (RCT) and chronic granuloma debridement was performed; 6 months later, the abscess and sinus had healed completely, and the periapical lesion had resolved. Odontogenic cutaneous sinus tracts are uncommon in the clinic. This case report reminds us of the significance of OCSTs and provides some implications for their diagnosis and treatment. PMID:27196471

  4. The occurrence of an abdominal wall abscess 11 years after appendectomy: report of a case.

    PubMed

    Matsuda, K; Masaki, T; Toyoshima, O; Ono, M; Muto, T

    1999-01-01

    Most complications after appendectomy occur within 10 days; however, we report herein the unusual case of a patient in whom a wound abscess was detected more than 10 years after an appendectomy. A 26-year-old woman presented to our hospital with nausea and vomiting, pain, and a mass in the right lower abdominal wall. She had undergone an appendectomy 11 years previously. Physical examination revealed a tender mass, 5 cm in diameter, under the appendectomy scar. An abdominal ultrasonography demonstrated a low-echoic mass lesion measuring 9.0 x 5.0 x 2.0 cm. Incision of the connective tissue revealed about 3 ml of cream-colored and odorless fluid in the abscess cavity. Fistulography revealed an abscess cavity not communicating with the bowel lumen. Floss was discovered in the connective tissue and removed. Debridement of the abscess wall was performed and a piece of the wall was sent for histologic examination. Pathological examination revealed panniculitis of the subcutaneous tissue, and panniculitis with granulation and granuloma of the abscess wall. This case report demonstrates that a preoperative diagnosis should be based not on one finding, but on all findings collected, inclusively. PMID:10489140

  5. Acceptance of Nordic snack bars in children aged 8–11 years

    PubMed Central

    Holmer, Anna; Hausner, Helene; Reinbach, Helene C.; Bredie, Wender L. P.; Wendin, Karin

    2012-01-01

    Background A health promoting diet is suggested to be tailored to regional circumstances to preserve the cultural diversity in eating habits, as well as contribute to more environmentally friendly eating. It may influence consumer acceptance, however, if the components of the diet differs considerably from their habitual food. Objective This study aimed to investigate whether snack bars composed of Nordic ingredients were accepted by 8–11 year-old Danish (n=134) and Swedish (n=109) children. Design A seven-point hedonic scale was used to measure the children's acceptance of five snack bars that varied in their composition of whole grains, berries and nuts. A preference rank ordering of the five bars was also performed. Results The results showed that samples that were rated highest in liking and were most preferred in both countries were a kamut/pumpkin bar and an oat/cranberry bar. The sample with the lowest rating that was also least preferred was a pumpernickel/sea buckthorn bar. Flavour was the most important determinant of overall liking followed by texture, odour and appearance. Conclusions Children's acceptances and preferences were highly influenced by the sensory characteristics of the bars, mainly flavour. In agreement with earlier studies, the novel food ingredients seemed to influence children's preferences. The Nordic snack bars may have a potential to be a snack option for Danish and Swedish school children, but repeated exposures to the products are recommended to increase children's acceptance. PMID:22545034

  6. Facial reconstruction of an 11-year-old female resident of 430 BC Athens.

    PubMed

    Papagrigorakis, Manolis J; Synodinos, Philippos N; Antoniadis, Aristomenis; Maravelakis, Emmanuel; Toulas, Panagiotis; Nilsson, Oscar; Baziotopoulou-Valavani, Effie

    2011-01-01

    Although modern standards of ideal proportions and facial esthetics are based mostly on observations of human faces as depicted in Classical Greek masterpieces of art, the real faces of ordinary ancient Greeks have, until now, remained elusive and subject to the imagination. Objective forensic techniques of facial reconstruction have never been applied before, because human skeletal material from Classical Greece has been extremely scarce, since most decent burials of that time required cremation. Here, the authors show stage by stage the facial reconstruction of an 11-year-old girl whose skull was unearthed in excellent condition from a mass grave with victims of the Plague that struck Athens of 430 bc. The original skull was replicated via three-dimensional modeling and rapid prototyping techniques. The reconstruction followed the Manchester method, laying the facial tissues from the surface of the skull outward by using depth-marker pegs as thickness guides. The shape, size, and position of the eyes, ears, nose, and mouth were determined according to features of the underlying skeletal tissues, whereas the hairstyle followed the fashion of the time. This is the first case of facial reconstruction of a layperson residing in Athens of the Golden Age of Pericles. It is ironic, however, that this unfortunate girl who lived such a short life in ancient Athens, will now, 2500 years later, have the chance to travel and be universally recognizable in a world much bigger than anybody in ancient Athens could have ever imagined. PMID:20936971

  7. Upward movement of plutonium to surface sediments during an 11-year field study.

    PubMed

    Kaplan, D I; Demirkanli, D I; Molz, F J; Beals, D M; Cadieux, J R; Halverson, J E

    2010-05-01

    An 11-year lysimeter study was established to monitor the movement of Pu through vadose zone sediments. Sediment Pu concentrations as a function of depth indicated that some Pu moved upward from the buried source material. Subsequent numerical modeling suggested that the upward movement was largely the result of invading grasses taking up the Pu and translocating it upward. The objective of this study was to determine if the Pu of surface sediments originated from atmosphere fallout or from the buried lysimeter source material (weapons-grade Pu), providing additional evidence that plants were involved in the upward migration of Pu. The (240)Pu/(239)Pu and (242)Pu/(239)Pu atomic fraction ratios of the lysimeter surface sediments, as determined by Thermal Ionization Mass Spectroscopy (TIMS), were 0.063 and 0.00045, respectively; consistent with the signatures of the weapons-grade Pu. Our numerical simulations indicate that because plants create a large water flux, small concentrations over multiple years may result in a measurable accumulation of Pu on the ground surface. These results may have implications on the conceptual model for calculating risk associated with long-term stewardship and monitored natural attenuation management of Pu contaminated subsurface and surface sediments. PMID:20227801

  8. Very Late Stent Thrombosis 11 Years after Implantation of a Drug-Eluting Stent

    PubMed Central

    Jepson, Nigel

    2015-01-01

    Very late stent thrombosis is an infrequent yet potentially fatal complication associated with drug-eluting stents. We report the case of an 88-year-old man who sustained an ST-segment-elevation myocardial infarction 11 years after initial sirolimus-eluting stent implantation. Optical coherence tomograms of the lesion showed that the focal incomplete endothelialization of the stent struts was the likely cause; neointimal formation, neoatherosclerosis, and late stent malapposition might also have contributed. To our knowledge, this is the longest reported intervening period between stent insertion and the development of an acute coronary event secondary to very late stent thrombosis. The associated prognostic and therapeutic implications are considerable, because they illuminate the uncertainties surrounding the optimal duration of antiplatelet therapy in patients who have drug-eluting stents. Clinicians face challenges in treating these patients, particularly when competing medical demands necessitate the discontinuation of antiplatelet therapy. In addition to the patient's case, we discuss factors that can contribute to very late stent thrombosis. PMID:26504449

  9. Rhinosporidium seeberi Nuclear Cycle Activities Using Confocal Microscopy.

    PubMed

    Delfino, Darly; Mendoza, Leonel; Vilela, Raquel

    2016-02-01

    Rhinosporidium seeberi is an uncultivated Ichthyosporean infecting animals, including humans. Recent studies suggested R. seeberi undergoes synchronized nuclear division without cytokinesis. We used confocal microscopy to investigate R. seeberi nuclear division cycles in formalin-fixed tissues stained with DAPI and phalloidin. We report that R. seeberi nuclei in juvenile and intermediary sporangia synchronously divided without cytokinesis. Intermediary sporangia display numerous 3-4 μm nuclei at different mitotic stages as well as a thick inner layer with strong affinity for phalloidin. Mature sporangia showed numerous 5-12 μm cell-walled endospores, each containing a 2-4 μm in diameter nucleus. Phalloidin did not bind to the inner layers of mature sporangia or endospores. The development of a "germinative zone" in the inner layer of mature sporangia containing hundreds of nuclei was also confirmed. This study establishes that during the R. seeberi life cycle synchronous nuclear divisions without cytokinesis takes place, resulting in the formation of thousands of nuclei. Cytokinesis, on the other hand, is a 1-time event and occurs in the latest stages of intermediate sporangia, after the formation of thousands of nuclei and just before mature sporangia development. PMID:26461427

  10. Cycling for Students with ASD: Self-Regulation Promotes Sustained Physical Activity

    ERIC Educational Resources Information Center

    Todd, Teri; Reid, Greg; Butler-Kisber, Lynn

    2010-01-01

    Individuals with autism often lack motivation to engage in sustained physical activity. Three adolescents with severe autism participated in a 16-week program and each regularly completed 30 min of cycling at the end of program. This study investigated the effect of a self-regulation instructional strategy on sustained cycling, which included…

  11. [Drowning versus cardiac ischemia: Cardiac arrest of an 11-year-old boy at a swimming lake].

    PubMed

    Födinger, A; Wöss, C; Semsroth, S; Stadlbauer, K H; Wenzel, V

    2015-11-01

    This report describes a case of sudden cardiac arrest and subsequent attempted cardiopulmonary resuscitation of an 11-year-old child on the shores of a swimming lake. Reports of eyewitnesses excluded the obviously suspected diagnosis of a drowning accident. The result of the autopsy was sudden cardiac death due to a congenital coronary anomaly (abnormal left coronary artery, ALCA). Favored by vigorous physical activity, this anomaly can lead to malignant arrhythmias because the ectopic coronary artery with its intramural course through the aortic wall is compressed during every systole. This pathology was not known to the boy or his family; in fact he liked sports but had suffered of a syncope once which was not followed up. Without a strong suspicion it is difficult to diagnose a coronary artery anomaly and it is often missed even in college athletes. Tragically, sudden cardiac arrest may be the first symptom of an undiagnosed abnormal coronary artery. Following syncope or chest pain during exercise with a normal electrocardiogram (ECG) cardiac imaging, such as computed tomography (CT) or angiography should be initiated in order to enable surgical repair of an abnormal coronary artery. PMID:26423258

  12. Amygdala/hippocampal activation during the menstrual cycle: evidence for lateralization of effects across different tasks.

    PubMed

    Lisofsky, Nina; Lindenberger, Ulman; Kühn, Simone

    2015-01-01

    Variations in hormonal levels between the follicular and the luteal phase of the female menstrual cycle are associated with variations in emotional and cognitive aspects of behavior. The functional neural correlates of these cycle-related variations have been explored in previous neuroimaging studies. We summarize the existing findings of functional magnetic resonance imaging (fMRI) studies to identify regions of increased brain activation in the follicular or luteal phases of the cycle that are concordant across studies. Eleven fMRI studies reporting coordinates of higher brain activation in one of the two main cycle phases were included in the analysis. Activation likelihood estimation was used to determine concordance. We found higher left amygdala/hippocampal activation during the luteal phase and higher right amygdala/hippocampal activation during the follicular phase. Additionally, the anterior cingulate cortex and temporal pole showed increased activation during the luteal phase and the superior temporal gyrus during the follicular phase. The observed pattern of cycle-dependent functional lateralization of the amygdala/hippocampal complex is consistent with findings on cycle-related behavioral variations and on sex differences in lateralization of activity in amygdala and hippocampus. PMID:25496966

  13. Diurnal cycles in serotonin acetyltransferase activity and cyclic GMP content of cultured chick pineal glands.

    PubMed

    Wainwright, S D

    1980-06-12

    Levels of serotonin N-acetyltransferase (NAT: acetul CoA:arylamine N-acetyltransferase; EC 2.1.1.5.) activity in the chick pineal gland exhibit a marked diurnal variation in birds kept under a diurnal cycle of ilumination. Activity begins to rise rapidly at the start of the dark phase of the cycle and reaches maximum levels at mid-dark phase about 25-fold greater than the minimum basal level at mid-light phase. Thereafter, the level of activity declines to the basal level about the start of the light phase. This diurnal cycle in chick pineal NAT activity found in vivo has recently been reproduced in vitro with intact glands incubated in organ culture. The mechanism of the 'biological clock' which regulates these variations in level of chick pineal NAT activity is unknown. However, I now report that chick pineal glands cultured under a diurnal cycle of illumination exhibit a diurnal cycle in content of cyclic GMP which roughly parallels the cycles in NAT activity. In contrast, there was no correlation between variations in pineal content of cyclic AMP and in level of NAT activity. PMID:6250035

  14. Possible chromospheric activity cycles in II Peg, UX Ari and V711 Tau

    NASA Astrophysics Data System (ADS)

    Buccino, Andrea P.; Mauas, Pablo J. D.

    2009-02-01

    We study the Mount Wilson indices we obtained indirectly from IUE high and low resolution spectra of the RS CVn-type systems II Peg (K2IV), UX Ari (K0IV+G5V) and V711 Tau (K1IV+G5V), extensively observed by IUE from 1978 to 1996. We analyze the activity signatures, which correspond to the primary star, with the Lomb-Scargle periodogram. From the analysis of V711 Tau data, we found a possible chromospheric cycle with a period of 18 years and a shorter ~3 year cycle, which could be associated to a chromospheric flip-flop cycle. The data of II Peg also suggest a chromospheric cycle of ~21 years and a flip-flop cycle of ~9 years. Finally, we obtained a possible chromospheric cycle of ~6 years for UX Ari.

  15. Martian induced magnetosphere variations with solar activity cycle

    NASA Astrophysics Data System (ADS)

    Fedorov, Andrey; Ronan, Modolo; Jarninen, Riku; Mazelle, Christian; Barabash, Stas

    2014-05-01

    During the last 6 years of ESA Mars Express mission we have accumulated plasma data taken inside and around the Martian induced magnetosphere corresponding to the increasing branch of solar activity. This data allows to make an enhanced study of the magnetosphere variations as a response of the solar activity level. Since Mars Express has no onboard magnetometer, we used the hybrid models of the Martian plasma environment to get a proper frame to make an adequate statistics of the magnetospheric response. In this paper we present a spatial distribution of the planetary plasma in the planetary wake as well as the ionsospheric escape as a function of the solar activity.

  16. Does crustacean ethoxyresorufin O-deethylase activity vary during the molting cycle?

    PubMed

    Hotard, Kate; Zou, Enmin

    2013-10-01

    The authors examined fluctuation in microsomal ethoxyresorufin O-deethylase (EROD) activity in the hepatopancreas during the molting cycle of the fiddler crab, Uca pugilator. Results showed that microsomal EROD activity fluctuates significantly during the molting cycle, with the lowest enzymatic activity occurring in the late premolt stage. These results clearly show that molting physiology influences crustacean EROD activity, suggesting that when using crustacean EROD assays in evaluating pollution, only individuals from the same molt stage should be used. The authors propose that the high level of EROD activity in postmolt and intermolt stages is an additional mechanism crustaceans use to prevent any untimely rise in ecdysteroid levels. PMID:23843096

  17. Illegal Substance Use among Italian High School Students: Trends over 11 Years (1999–2009)

    PubMed Central

    Molinaro, Sabrina; Siciliano, Valeria; Curzio, Olivia; Denoth, Francesca; Salvadori, Stefano; Mariani, Fabio

    2011-01-01

    Purpose To monitor changes in habits in drug use among Italian high school students. Methods Cross-sectional European School Survey Project on Alcohol and Other Drugs (ESPAD) carried out in Italy annually for 11 years (1999–2009) with representative samples of youth attending high school. The sample size considered ranges from 15,752 to 41,365 students and response rate ranged from 85.5% to 98.6%. Data were analyzed to obtain measures of life-time prevalence (LT), use in the last year (LY), use in the last 30 days (LM), frequent use. Comparisons utilized difference in proportion tests. Tests for linear trends in proportion were performed using the Royston p trend test. Results When the time-averaged value was considered, cannabis (30% LT) was the most, and heroin the least (2%) frequently used, with cocaine (5%), hallucinogens (2%) and stimulants (2%) in between. A clear gender gap is evident for all drugs, more obvious for hallucinogens (average M/F LY prevalence ratio 2, range 1.7–2.4, p<0.05), less for cannabis (average M/F LY prevalence ratio 1.3, range 1.2–1.5, p<0.05). Data shows a change in trend between 2005 and 2008; in 2006 the trend for cannabis use and availability dropped and the price rose, while from 2005 cocaine and stimulant use prevalence showed a substantial increase and the price went down. After 2008 use of all substances seems to have decreased. Conclusions Drug use is widespread among students in Italy, with cannabis being the most and heroin the least prevalent. Girls are less vulnerable than boys to illegal drug use. In recent years, a decrease in heroin use is overbalanced by a marked rise in hallucinogen and stimulant use. PMID:21695199

  18. An 11-year retrospective review of venlafaxine ingestion in children from the California Poison Control System.

    PubMed

    Doroudgar, S; Perry, P J; Lackey, G D; Veselova, N G; Chuang, H M; Albertson, T E

    2016-07-01

    Venlafaxine is commonly used in the United States for approved and non-Food and Drug Administration-approved indications in adults. It is used off-label to treat children for psychiatric diagnoses. The aim of the study was to describe venlafaxine toxicities in children and to identify the venlafaxine dose per weight that correlates with toxicities. An 11-year retrospective study of venlafaxine ingestion in children was performed using the California Poison Control System (CPCS) database. Data was extracted from phone calls received by CPCS clinicians and follow-up phone calls made to assess the patient's progress in a health-care setting. Inclusion criteria were venlafaxine ingestion cases reported to CPCS between January 2001 and December 2011, children aged 20 years and under, venlafaxine as the only ingested substance, managed in a health-care facility, and followed to a known outcome. Two hundred sixty-two cases met the study criteria. Common presentations included gastrointestinal (14.9%), altered mental status (13.7%), and tachycardia (13.4%). The majority of the cases resulted in no effect (51.5%) or minor effect (19.9%). The average estimated dose per weight was 18.3 mg/kg in all patients and 64.5 mg/kg in those experiencing moderate-to-severe adverse effects. Seizures occurred in only 4 of the 262 cases at doses ranging from 1500 to 7500 mg. Although the estimated dose per weight exceeded 10 mg/kg for the majority of the cases, only 12 cases resulted in moderate or severe outcomes. The majority of venlafaxine ingestion cases in children resulted in either no clinical effects or minor clinical effects. PMID:26351291

  19. Regeneration of a Coastal Pine (Pinus thunbergii Parl.) Forest 11 Years after Thinning, Niigata, Japan

    PubMed Central

    Zhu, Jiaojun; Gonda, Yutaka; Yu, Lizhong; Li, Fengqin; Yan, Qiaoling; Sun, Yirong

    2012-01-01

    To examine the effects of thinning intensity on wind vulnerability and regeneration in a coastal pine (Pinus thunbergii) forest, thinning with intensities of 20%, 30% and 50% was conducted in December 1997; there was an unthinned treatment as the control (total 8 stands). We re-measured the permanent sites to assess the regeneration characteristics 11 years after thinning. In the 50% thinned stand, seedlings aged from 2 to 10 years exhibited the highest pine seedling density and growth. The age composition ranged from 1–3 years with densities of 9.9 and 5.1 seedlings m−2 in 30% and 20% thinned stands; only 1-year-old seedlings with a density of 6.1 seedlings m−2 in the unthinned stand. Similar trends were found for the regeneration of broadleaved species such as Robinia pseudoacacia and Prunus serrulata. We speculate that the canopy openness and moss coverage contributed to the regeneration success in the 50% thinned stand, while the higher litter depth and lack of soil moisture induced the regeneration failure in the unthinned stand. The stands thinned at 20% or 30% were less favourable for pine regeneration than the stands thinned at 50%. Therefore, thinning with less than 30% canopy openness (20% and 30% thinned stands) should be avoided, and thinning at higher than 30% canopy openness (50% thinned stand, approximately 1500 stems ha−1 at ages 40–50 years) is suggested for increasing regeneration in the coastal pine forest. The implications of thinning-based silviculture in the coastal pine forest management are also discussed. The ongoing development of the broadleaved seedlings calls for further observations. PMID:23091632

  20. Manual control age and sex differences in 4 to 11 year old children.

    PubMed

    Flatters, Ian; Hill, Liam J B; Williams, Justin H G; Barber, Sally E; Mon-Williams, Mark

    2014-01-01

    To what degree does being male or female influence the development of manual skills in pre-pubescent children? This question is important because of the emphasis placed on developing important new manual skills during this period of a child's education (e.g. writing, drawing, using computers). We investigated age and sex-differences in the ability of 422 children to control a handheld stylus. A task battery deployed using tablet PC technology presented interactive visual targets on a computer screen whilst simultaneously recording participant's objective kinematic responses, via their interactions with the on-screen stimuli using the handheld stylus. The battery required children use the stylus to: (i) make a series of aiming movements, (ii) trace a series of abstract shapes and (iii) track a moving object. The tasks were not familiar to the children, allowing measurement of a general ability that might be meaningfully labelled 'manual control', whilst minimising culturally determined differences in experience (as much as possible). A reliable interaction between sex and age was found on the aiming task, with girls' movement times being faster than boys in younger age groups (e.g. 4-5 years) but with this pattern reversing in older children (10-11 years). The improved performance in older boys on the aiming task is consistent with prior evidence of a male advantage for gross-motor aiming tasks, which begins to emerge during adolescence. A small but reliable sex difference was found in tracing skill, with girls showing a slightly higher level of performance than boys irrespective of age. There were no reliable sex differences between boys and girls on the tracking task. Overall, the findings suggest that prepubescent girls are more likely to have superior manual control abilities for performing novel tasks. However, these small population differences do not suggest that the sexes require different educational support whilst developing their manual skills. PMID

  1. Regeneration of a coastal pine (Pinus thunbergii Parl.) forest 11 years after thinning, Niigata, Japan.

    PubMed

    Zhu, Jiaojun; Gonda, Yutaka; Yu, Lizhong; Li, Fengqin; Yan, Qiaoling; Sun, Yirong

    2012-01-01

    To examine the effects of thinning intensity on wind vulnerability and regeneration in a coastal pine (Pinus thunbergii) forest, thinning with intensities of 20%, 30% and 50% was conducted in December 1997; there was an unthinned treatment as the control (total 8 stands). We re-measured the permanent sites to assess the regeneration characteristics 11 years after thinning. In the 50% thinned stand, seedlings aged from 2 to 10 years exhibited the highest pine seedling density and growth. The age composition ranged from 1-3 years with densities of 9.9 and 5.1 seedlings m(-2) in 30% and 20% thinned stands; only 1-year-old seedlings with a density of 6.1 seedlings m(-2) in the unthinned stand. Similar trends were found for the regeneration of broadleaved species such as Robinia pseudoacacia and Prunus serrulata. We speculate that the canopy openness and moss coverage contributed to the regeneration success in the 50% thinned stand, while the higher litter depth and lack of soil moisture induced the regeneration failure in the unthinned stand. The stands thinned at 20% or 30% were less favourable for pine regeneration than the stands thinned at 50%. Therefore, thinning with less than 30% canopy openness (20% and 30% thinned stands) should be avoided, and thinning at higher than 30% canopy openness (50% thinned stand, approximately 1500 stems ha(-1) at ages 40-50 years) is suggested for increasing regeneration in the coastal pine forest. The implications of thinning-based silviculture in the coastal pine forest management are also discussed. The ongoing development of the broadleaved seedlings calls for further observations. PMID:23091632

  2. Coroner autopsy study of homicides in Rivers State of Nigeria: 11-year review.

    PubMed

    Obiorah, C C; Amakiri, C N

    2014-01-01

    As most developing countries, including Nigeria, grapple with economic crisis, poor human capital development and high levels of income inequality, violent crimes - especially homicides - continue to be a cause for concern. We studied the pathology and demographic distribution of homicides in Rivers State of Nigeria expecting that the findings would be useful in formulating preventive strategies. Reports of homicide autopsies in the state for 11 years were retrospectively scrutinized for age, gender, type of weapon, site of injury, circumstances, mechanisms and causes of death. The data were analyzed using SPSS version 17. Homicides constituted 50.5% of the medicolegal autopsies. Although the overall male:female ratio was 12.4 : 1, there was variation with weapon. Deaths by firearm had the highest male:female ratio of 24.6 : 1. The mean and peak ages were 29.2 ± 11.4 and 21-30 years, respectively, while the range was 1 to 96 years. Firearms were the most common weapons, at 68.9%, hemorrhagic shock and head injuries at 61.5% and 28.2% respectively were the most common mechanisms and causes of death. Armed robbery incidents were the most common circumstances, while the head was the most common site of injury at 48.8%. The homicide rate is high in our environment and most homicides are committed during armed robberies using firearms. Improving medical care and providing emergency medical services will reduce cases of deaths from homicides, most of which occur due to manageable hemorrhagic shock. Increasing the drive towards controlling illegal arms acquisition and possession will reduce the present carnage in the state. PMID:23945261

  3. Frowning and Jaw Clenching Muscle Activity Reflects the Perception of Effort During Incremental Workload Cycling

    PubMed Central

    Huang, Ding-Hau; Chou, Shih-Wei; Chen, Yi-Lang; Chiou, Wen-Ko

    2014-01-01

    The present study aimed to investigate whether facial electromyography (EMG) recordings reflect the perception of effort and primary active lower limb muscle activity during incremental workload cycling. The effects of exercise intensity on EMG activity of the corrugator supercilii (CS), masseter and vastus lateralis (VL) muscles, heart rate (HR) and the rating of perceived exertion (RPE) were investigated, and the correlations among these parameters were determined. Eighteen males and 15 females performed continuous incremental workload cycling exercise until exhaustion. CS, masseter and VL muscle activities were continuously recorded using EMG during exercise. HR was also continuously monitored during the test. During the final 30 s of each stage of cycle ergometer exercise, participants were asked to report their feeling of exertion on the adult OMNI-Cycle RPE. HR and EMG activity of the facial muscles and the primary active lower limb muscle were strongly correlated with RPE; they increased with power output. Furthermore, facial muscle activity increased significantly during high-intensity exercise. Masseter muscle activity was strongly and positively correlated with HR, RPE and VL activity. The present investigation supports the view that facial EMG activity reflects the perception of effort. The jaw clenching facial expression can be considered an important factor for improving the reporting of perceived effort during high-intensity exercise in males and females. Key points Frowning and jaw clenching muscle activity reflects the perception of effort during incremental workload cycling. EMG activity of the masseter muscle was strongly and positively correlated with RPE, HR and lower limb EMG activity during incremental workload cycling. The jaw clenching facial expression can be considered an important factor for estimating the intensity of effort. PMID:25435786

  4. A cell cycle-controlled redox switch regulates the topoisomerase IV activity

    PubMed Central

    Narayanan, Sharath; Janakiraman, Balaganesh; Kumar, Lokesh

    2015-01-01

    Topoisomerase IV (topo IV), an essential factor during chromosome segregation, resolves the catenated chromosomes at the end of each replication cycle. How the decatenating activity of the topo IV is regulated during the early stages of the chromosome cycle despite being in continuous association with the chromosome remains poorly understood. Here we report a novel cell cycle-regulated protein in Caulobacter crescentus, NstA (negative switch for topo IV decatenation activity), that inhibits the decatenation activity of the topo IV during early stages of the cell cycle. We demonstrate that in C. crescentus, NstA acts by binding to the ParC DNA-binding subunit of topo IV. Most importantly, we uncover a dynamic oscillation of the intracellular redox state during the cell cycle, which correlates with and controls NstA activity. Thus, we propose that predetermined dynamic intracellular redox fluctuations may act as a global regulatory switch to control cellular development and cell cycle progression and may help retain pathogens in a suitable cell cycle state when encountering redox stress from the host immune response. PMID:26063575

  5. Viral activities and life cycles in deep subseafloor sediments.

    PubMed

    Engelhardt, Tim; Orsi, William D; Jørgensen, Bo Barker

    2015-12-01

    Viruses are highly abundant in marine subsurface sediments and can even exceed the number of prokaryotes. However, their activity and quantitative impact on microbial populations are still poorly understood. Here, we use gene expression data from published continental margin subseafloor metatranscriptomes to qualitatively assess viral diversity and activity in sediments up to 159 metres below seafloor (mbsf). Mining of the metatranscriptomic data revealed 4651 representative viral homologues (RVHs), representing 2.2% of all metatranscriptome sequence reads, which have close translated homology (average 77%, range 60-97% amino acid identity) to viral proteins. Archaea-infecting RVHs are exclusively detected in the upper 30 mbsf, whereas RVHs for filamentous inoviruses predominate in the deepest sediment layers. RVHs indicative of lysogenic phage-host interactions and lytic activity, notably cell lysis, are detected at all analysed depths and suggest a dynamic virus-host association in the marine deep biosphere studied here. Ongoing lytic viral activity is further indicated by the expression of clustered, regularly interspaced, short palindromic repeat-associated cascade genes involved in cellular defence against viral attacks. The data indicate the activity of viruses in subsurface sediment of the Peruvian margin and suggest that viruses indeed cause cell mortality and may play an important role in the turnover of subseafloor microbial biomass. PMID:26109514

  6. Life Cycle of the Salmon. Ocean Related Curriculum Activities.

    ERIC Educational Resources Information Center

    Tarabochia, Kathy

    The ocean affects all of our lives. Therefore, awareness of and information about the interconnections between humans and oceans are prerequisites to making sound decisions for the future. Project ORCA (Ocean Related Curriculum Activities) has developed interdisciplinary curriculum materials designed to meet the needs of students and teachers…

  7. Do Male And Female Cyclists' Cortical Activity Differ Before and During Cycling Exercise?

    PubMed

    Ludyga, Sebastian; Gronwald, Thomas; Hottenrott, Kuno

    2015-12-01

    Although men and women are suggested to vary in resistance to fatigue, possible sex difference in its central component have rarely been investigated via electroencephalography (EEG). Therefore, we examined differences in cortical activity between male and female cyclists (n = 26) during cycling exercise. Participants performed an incremental test to derive the anaerobic threshold from the lactate power curve. In addition, cyclists' cortical activity was recorded with EEG before and during cycling exercise. Whereas women showed higher frontal alpha and beta activity at rest, no sex-specific differences of relative EEG spectral power occurred during cycling at higher intensity. Women and men's brains respond similarly during submaximal cycling, as both sexes show an inverted U-shaped curve of alpha power. Therefore, sex differences observable at rest vanish after the onset of exercise. PMID:26866769

  8. Looking for activity cycles in late-type Kepler stars using time-frequency analysis

    NASA Astrophysics Data System (ADS)

    Vida, K.; Oláh, K.; Szabó, R.

    2014-07-01

    We analyse light curves covering four years of 39 fast-rotating (Prot ≲ 1 d) late-type active stars from the Kepler data base. Using time-frequency analysis (short-term Fourier transform), we find hints for activity cycles of 300-900 d at nine targets from the changing typical latitude of the starspots, which with the differential rotation of the stellar surface change the observed rotation period over the activity cycle. We also give a lowest estimation for the shear parameter of the differential rotation, which is ≈0.001 for the cycling targets. These results populate the less studied, short-period end of the rotation-cycle length relation.

  9. Contextualizing Solar Cycle 24: Report on the Development of a Homogenous Database of Bipolar Active Regions Spanning Four Cycles

    NASA Astrophysics Data System (ADS)

    Munoz-Jaramillo, A.; Werginz, Z. A.; DeLuca, M. D.; Vargas-Acosta, J. P.; Longcope, D. W.; Harvey, J. W.; Martens, P.; Zhang, J.; Vargas-Dominguez, S.; DeForest, C. E.; Lamb, D. A.

    2015-12-01

    The solar cycle can be understood as a process that alternates the large-scale magnetic field of the Sun between poloidal and toroidal configurations. Although the process that transitions the solar cycle between toroidal and poloidal phases is still not fully understood, theoretical studies, and observational evidence, suggest that this process is driven by the emergence and decay of bipolar magnetic regions (BMRs) at the photosphere. Furthermore, the emergence of BMRs at the photosphere is the main driver behind solar variability and solar activity in general; making the study of their properties doubly important for heliospheric physics. However, in spite of their critical role, there is still no unified catalog of BMRs spanning multiple instruments and covering the entire period of systematic measurement of the solar magnetic field (i.e. 1975 to present).In this presentation we discuss an ongoing project to address this deficiency by applying our Bipolar Active Region Detection (BARD) code on full disk magnetograms measured by the 512 (1975-1993) and SPMG (1992-2003) instruments at the Kitt Peak Vacuum Telescope (KPVT), SOHO/MDI (1996-2011) and SDO/HMI (2010-present). First we will discuss the results of our revitalization of 512 and SPMG KPVT data, then we will discuss how our BARD code operates, and finally report the results of our cross-callibration.The corrected and improved KPVT magnetograms will be made available through the National Solar Observatory (NSO) and Virtual Solar Observatory (VSO), including updated synoptic maps produced by running the corrected KPVT magnetograms though the SOLIS pipeline. The homogeneous active region database will be made public by the end of 2017 once it has reached a satisfactory level of quality and maturity. The Figure shows all bipolar active regions present in our database (as of Aug 2015) colored according to the sign of their leading polarity. Marker size is indicative of the total active region flux. Anti

  10. Peroxide bond strength of antimalarial drugs containing an endoperoxide cycle. Relation with biological activity.

    PubMed

    Fernández, Israel; Robert, Anne

    2011-06-01

    Several endoperoxide compounds are very efficient antimalarial analogues of the natural drug artemisinin. Quantum chemical calculations have been used to correlate the computed free energies of the O-O bond with respect to the total number of oxygen atoms contained in the cycle, and with the size/strain of the cycle (5- or 6-membered cycles). The gas-phase homolysis of the O-O bond has been studied for five- and six-membered oxygenated cycles which are models of the "real" drugs. Our results indicate that, in 6-membered cycles, the stability order is the following: 1,2-dioxane > 1,2,4-trioxane > 1,2,4,5-tetraoxane. In cycles containing 3 oxygen atoms, the 5-membered cycle 1,2,4-trioxolane was found much less stable than its 6-membered counterpart 1,2,4-trioxane. This feature indicates the possible role of the cycle strain for the O-O bond stability, and may also explain the high antimalarial activity of some trioxolane derivatives. Similar trends in the O-O bond strength have been found for the real antimalarial drugs. However, the O-O bond stability is not in itself a decisive argument to anticipate the antimalarial activity of drugs. PMID:21487624

  11. Is the Valles caldera entering a new cycle of activity?

    SciTech Connect

    Wolff, J.A.; Gardner, J.N.

    1995-05-01

    The Valles caldera formed during two major rhyolitic ignimbrite eruptive episodes (the Bandelier Tuff) at 1.61 and 1.22 Ma, after some 12 m.y. of activity in the Jemez Mountains volcanic field, New Mexico. Several subsequent eruptions between 1.22 and 0.52 Ma produced dominantly high-silica rhyolite lava domes and tephras within the caldera. These were followed by a dormancy of 0.46 m.y. prior to the most recent intracaldera activity, the longest hiatus since the inception of the Bandelier magma system at approximately 1.8 Ma. The youngest volcanic activity at approximately 60 ka produced the SW moat rhyolites, a series of lavas and tuffs that display abundant petrologic evidence of being newly generated melts. Petrographic textures conform closely to published predictions for silicic magmas generated by intrusion of basaltic magma into continental crust. The Valles caldera may currently be the site of renewed silicic magma generation, induced by intrusion of mafic magma at depth. Recent seismic investigations revealed the presence of a large low-velocity anomaly in the lower crust beneath the caldera. The generally aseismic character of the caldera, despite abundant regional seismicity, may be attributed to a heated crustal column, the local effect of 13 m.y. of magmatism and emplacement of mid-crustal plutons. 24 refs., 3 figs.

  12. MDR-TB Outbreak among HIV-Negative Tunisian Patients followed during 11 Years

    PubMed Central

    Dekhil, Naira; Meftahi, Nedra; Mhenni, Besma; Ben Fraj, Saloua; Haltiti, Raja; Belhaj, Sameh; Mardassi, Helmi

    2016-01-01

    Background Multidrug-resistant tuberculosis (MDR-TB) outbreaks that evolve, from the outset, in a context strictly negative for HIV infection deserve special consideration since they reflect the true intrinsic epidemic potential of the causative strain. To our knowledge, the long-term evolution of such exceptional outbreaks and the treatment outcomes for the involved patients has never been reported hitherto. Here we provide a thorough description, over an 11-year period, of an MDR-TB outbreak that emerged and expanded in an HIV-negative context, Northern Tunisia. Methodology/Principal Findings From October 2001 to June 2011, the MDR-TB outbreak involved 48 HIV-negative individuals that are mainly young (mean age 31.09 yrs; 89.6% male) and noninstitutionalized. Drug susceptibility testing coupled to mutational analysis revealed that initial transmission involved an isolate that was simultaneously resistant to isoniazid, rifampicin, ethambutol, and streptomycin. The causative Haarlem3-ST50 outbreak strain expanded mainly as an 11-banded IS6110 RFLP profile (77.1%), from which a 12-banded subclone evolved. After undergoing a 2-year treatment with second-line drugs, 22 (45.8%) patients were cured and 3 (6.2%) completed treatment, thus yielding an overall treatment success rate of 52.1%. Among the patients that experienced unfavorable treatment outcomes, 10 (20.8%) failed treatment, 3 (6.2%) were lost to follow-up, 5 (10.4%) died, and 5 (10.4%) could not be evaluated. Poor adherence to treatment was found to be the main independent predictor of unfavorable outcomes (HR: 9.15; 95% CI 1.72–48.73; P = 0.014). Intriguingly, the evolved 12-banded subclone proved significantly associated with unfavorable outcomes (HR: 4.90; 95% CI 1.04–23.04, P = 0.044). High rate of fatality and relapse was further demonstrated at the long-term, since 70% of those whose treatment failed have died, and 24% among those deemed successfully treated have relapsed. Conclusions

  13. Cell cycle-dependent regulation of RNA polymerase II basal transcription activity.

    PubMed Central

    Yonaha, M; Chibazakura, T; Kitajima, S; Yasukochi, Y

    1995-01-01

    Regulation of transcription by RNA polymerase II (pol II) in eukaryotic cells requires both basal and regulatory transcription factors. In this report we have investigated in vitro pol II basal transcription activity during the cell cycle by using nuclear extracts from synchronized HeLa cells. It is shown that pol II basal transcription activity is low in the S and G2 phases and high in early G1 phase and TFIID is the rate limiting component of pol II basal transcription activity during the cell cycle. Further analyses reveal that TFIID exists as a less active form in the S and G2 phases and nuclear extracts from S and G2 phase cells contain a heat-sensitive repressor(s) of TATA box binding protein (TBP). These results suggest that pol II basal transcription activity is regulated by a qualitative change in the TFIID complex, which could involve repression of TBP, during the cell cycle. Images PMID:7479063

  14. The activity cycle of 67P/Churyumov-Gerasimenko

    NASA Astrophysics Data System (ADS)

    Snodgrass, C.; Barrera, L.; Boehnhardt, H.; Guilbert-Lepoutre, A.; Hainaut, O.; Hutsemékers, D.; Jehin, E.; Meech, K.; Opitom, C.; Schulz, R.; Tozzi, G.; Tubiana, C.

    2014-07-01

    We present ground-based observations of comet 67P/Churyumov-Gerasimenko, target of the Rosetta mission, and an assessment on its activity levels. Based on imaging in the R-band, we measure the brightness of the coma within various apertures and use this to assess the amount of dust in the coma. We find that the comet begins to show detectable activity at a pre-perihelion distance from the Sun of 4.3 au, and then shows a smooth increase in production to a peak around one month after perihelion passage. The behaviour of the comet is consistent from one orbit to another, based on archival images taken over three apparitions, and we therefore use the heliocentric lightcurve to make predictions for the 2014/5 period while Rosetta is operating at the comet. We find that the Afρ parameter, measured within an aperture of radius 10,000 km at the comet, is proportional to r^{-3.2}, pre-perihelion [1]. We also attempt to make predictions on the gas production rate by fitting a model to the observed brightness values. This is done by assuming various parameters about the nucleus and dust, many of which are reasonably well constrained for 67P, and solving an energy balance equation that gives the sublimation rate of various ices as a function of solar illumination [2]. The model then links the gas production rate to the total amount of dust in the coma, and its brightness. We find that only a small fraction of the surface area (1.4 %) needs to be active for water sublimation, with an extra peak (up to 4 %) for a month either side of perihelion, while an even smaller area is producing CO_2 (0.04-0.09 %) [1]. The predictions can now be tested against new observations, and we will present the latest results from our 2014 monitoring of 67P. We are performing regular R-band imaging on the comet using the VLT, and early indications in March 2014 indicate that the comet does appear to have returned to activity as expected. By the time of the ACM meeting we will have around 4 months

  15. Solar Wind and Magnetic Storms in 24-th Cycle of Solar Activity

    NASA Astrophysics Data System (ADS)

    Val'chuk, T. E.

    2013-01-01

    Slow growth of 24-th solar cycle allows adding of this cycle to the type of low cycles. Geomagnetic activity is not expensive too - strong geomagnetic storms were absent in the beginning of growth branch of this cycle. Very prolonged minimum was lasting about 4 years. We may remember that century minimum of solar activity was proposed after XX century high strong cycles. It may be - we look this situation now in 2012. Our work is connected with sporadic phenomena in 24-th cycle. These more or less intensive variations of solar activity are not predicted, they are caused by flowing up of new magnetic fields of spots, the excitement of flares, intensive plasma flows, coronal mass ejections (CME) and filament eruptions. Now two last versions (CME and filaments) are primary. Geomagnetic activity on a descending phase of solar cycle depends on quality of coronal holes providing the recurrent geomagnetic storms. Sporadic phenomena, which generated geomagnetic storms in Earth magnetosphere if flare flows reached the Earth magnetosphere and transferred it the energy are more interesting for us - they are the valuable characteristics of 24-th cycle. The disturbed period of several geomagnetic storms was generated by solar active region N11429. It is one sample only, this case is difficult and indicative. Replacing each other scenarios describe geomagnetic variations at the beginning of March 2012. Detailed consideration of this interval revealed its communication with sporadic events on the Sun. The structural configuration of plasma in flare flows was defined by means fractal dimension calculations of solar plasma parameters: velocity Vx and density N in flare streams.

  16. Periods of Highly Synchronous, Non-Reentrant Endocardial Activation Cycles Occur During Long Duration Ventricular Fibrillation

    PubMed Central

    Robichaux, Robert P.; Dosdall, Derek J.; Osorio, Jose; Garner, Nicholas W.; Li, Li; Huang, Jian; Ideker, Raymond E.

    2010-01-01

    Background Little is known about long-duration ventricular fibrillation (LDVF), lasting 1-10 minutes when resuscitation is still possible. Methods and Results To determine global LV endocardial activation during LDVF, 6 canines (9.5±0.8 kg) received a 64-electrode basket catheter in the left ventricle (LV), a right ventricular (RV) catheter, and a 12-lead ECG. Activation sequences of 15 successive cycles after initiation and after 1, 2, 3, 5, 7, and 10 minutes of LDVF were determined. Early during VF, LV endocardial activation was complex and present throughout most (78.0±9.7%) of each cycle consistent with reentry. After 3-7 min of LDVF in 5 animals, endocardial activation became highly synchronized and present for only a small percentage of each cycle (18.2±7.7%), indicating that LV endocardial reentry was no longer present. During this synchronization, activations arose focally in Purkinje fibers and spread as large wavefronts to excite the Purkinje system followed by the subendocardial working myocardium. During this synchronization, the ECG continued to appear irregular, consistent with VF, and LV cycle length (183±29 ms) was significantly different than RV cycle length (144±14 ms) and significantly different than the LV cycle length when synchronization was not present (130±11 ms). Conclusion After 3-7 minutes of LDVF, a highly organized, synchronous, focal LV endocardial activation pattern frequently occurs that is not consistent with reentry but is consistent with triggered activity or abnormal automaticity in Purkinje fibers. The ECG continues to appear irregular during this period, partially because of differences in LV and RV cycle lengths. PMID:20487123

  17. Active vibration and balance system for closed cycle thermodynamic machines

    NASA Technical Reports Server (NTRS)

    Qiu, Songgang (Inventor); Augenblick, John E. (Inventor); Peterson, Allen A. (Inventor); White, Maurice A. (Inventor)

    2004-01-01

    An active balance system is provided for counterbalancing vibrations of an axially reciprocating machine. The balance system includes a support member, a flexure assembly, a counterbalance mass, and a linear motor or an actuator. The support member is configured for attachment to the machine. The flexure assembly includes at least one flat spring having connections along a central portion and an outer peripheral portion. One of the central portion and the outer peripheral portion is fixedly mounted to the support member. The counterbalance mass is fixedly carried by the flexure assembly along another of the central portion and the outer peripheral portion. The linear motor has one of a stator and a mover fixedly mounted to the support member and another of the stator and the mover fixedly mounted to the counterbalance mass. The linear motor is operative to axially reciprocate the counterbalance mass. A method is also provided.

  18. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

    SciTech Connect

    Ding, Li; Huang, Yong; Du, Qian; Dong, Feng; Zhao, Xiaomin; Zhang, Wenlong; Xu, Xingang; Tong, Dewen

    2014-03-07

    Highlights: • TGEV N protein reduces cell viability by inducing cell cycle arrest and apoptosis. • TGEV N protein induces cell cycle arrest and apoptosis by regulating p53 signaling. • TGEV N protein plays important roles in TGEV-induced cell cycle arrest and apoptosis. - Abstract: Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.

  19. OECD/NEA Ongoing activities related to the nuclear fuel cycle

    SciTech Connect

    Cornet, S.M.; McCarthy, K.; Chauvin, N.

    2013-07-01

    As part of its role in encouraging international collaboration, the OECD Nuclear Energy Agency is coordinating a series of projects related to the Nuclear Fuel Cycle. The Nuclear Science Committee (NSC) Working Party on Scientific Issues of the Nuclear Fuel Cycle (WPFC) comprises five different expert groups covering all aspects of the fuel cycle from front to back-end. Activities related to fuels, materials, physics, separation chemistry, and fuel cycles scenarios are being undertaken. By publishing state-of-the-art reports and organizing workshops, the groups are able to disseminate recent research advancements to the international community. Current activities mainly focus on advanced nuclear systems, and experts are working on analyzing results and establishing challenges associated to the adoption of new materials and fuels. By comparing different codes, the Expert Group on Advanced Fuel Cycle Scenarios is aiming at gaining further understanding of the scientific issues and specific national needs associated with the implementation of advanced fuel cycles. At the back end of the fuel cycle, separation technologies (aqueous and pyrochemical processing) are being assessed. Current and future activities comprise studies on minor actinides separation and post Fukushima studies. Regular workshops are also organized to discuss recent developments on Partitioning and Transmutation. In addition, the Nuclear Development Committee (NDC) focuses on the analysis of the economics of nuclear power across the fuel cycle in the context of changes of electricity markets, social acceptance and technological advances and assesses the availability of the nuclear fuel and infrastructure required for the deployment of existing and future nuclear power. The Expert Group on the Economics of the Back End of the Nuclear Fuel Cycle (EBENFC), in particular, is looking at assessing economic and financial issues related to the long term management of spent nuclear fuel. (authors)

  20. The effect of cadence on timing of muscle activation and mechanical output in cycling: on the activation dynamics hypothesis.

    PubMed

    McGhie, David; Ettema, Gertjan

    2011-02-01

    The purpose of this study was to examine the activation dynamics hypothesis, which states that, in cycling, the pattern between muscle activity and crank position shifts in regard to its angle in the crank cycle with increasing cadence to maintain invariant positioning of the mechanical output. We measured surface EMG of six muscles, and by means of force measurements at the crank and inverse dynamics calculated hip, knee, and ankle joint dynamics during cycling at five cadences (60-100 rpm) at 75% of maximal power in trained cyclists. The joint dynamics (net muscle moment and power) showed a consistent positive phase shift with increasing cadence. The phase shift in muscle activation patterns was highly variable amongst subjects and was, on average, close to zero. Our results are in contradiction with the activation dynamics hypothesis. PMID:20594872

  1. Finding year-long activity cycles in ground-based and space-borne photometry

    NASA Astrophysics Data System (ADS)

    Vida, Krisztián; Oláh, Katalin; Szabó, Róbert

    2015-08-01

    Using long­term ground­based photometry of fast­rotating M­-dwarfs (EY Dra, V405 And, GSC 3377­0296 and V374 Peg), all with rotational periods near 0.5 day, but with different internal structures, we found activity cycles in the form of long-­term brightness changes, on the time scales of about one year. Using the cycling stars as templates, we searched for similar, fast rotating (P < 1d), active, late­-type targets in the Kepler Input Catalogue. Analysing the light curves of these 39 stars, we found hints of 300­-900 day­-long cycles in 9 cases detecting small variations in the rotation periods caused by differential rotation and the changing spot emergence latitudes over the cycle (i.e., the butterfly diagram).

  2. The solar cycle variation of the rates of CMEs and related activity

    NASA Technical Reports Server (NTRS)

    Webb, David F.

    1991-01-01

    Coronal mass ejections (CMEs) are an important aspect of the physics of the corona and heliosphere. This paper presents results of a study of occurrence frequencies of CMEs and related activity tracers over more than a complete solar activity cycle. To properly estimate occurrence rates, observed CME rates must be corrected for instrument duty cycles, detection efficiencies away from the skyplane, mass detection thresholds, and geometrical considerations. These corrections are evaluated using CME data from 1976-1989 obtained with the Skylab, SMM and SOLWIND coronagraphs and the Helios-2 photometers. The major results are: (1) the occurrence rate of CMEs tends to track the activity cycle in both amplitude and phase; (2) the corrected rates from different instruments are reasonably consistent; and (3) over the long term, no one class of solar activity tracer is better correlated with CME rate than any other (with the possible exception of type II bursts).

  3. Relationship between skin temperature and muscle activation during incremental cycle exercise.

    PubMed

    Priego Quesada, Jose I; Carpes, Felipe P; Bini, Rodrigo R; Salvador Palmer, Rosario; Pérez-Soriano, Pedro; Cibrián Ortiz de Anda, Rosa M

    2015-02-01

    While different studies showed that better fitness level adds to the efficiency of the thermoregulatory system, the relationship between muscular effort and skin temperature is still unknown. Therefore, the present study assessed the relationship between neuromuscular activation and skin temperature during cycle exercise. Ten physically active participants performed an incremental workload cycling test to exhaustion while neuromuscular activations were recorded (via surface electromyography - EMG) from rectus femoris, vastus lateralis, biceps femoris and gastrocnemius medialis. Thermographic images were recorded before, immediately after and 10 min after finishing the cycling test, at four body regions of interest corresponding to the muscles where neuromuscular activations were monitored. Frequency band analysis was conducted to assess spectral properties of EMG signals in order to infer on priority in recruitment of motor units. Significant inverse relationship between changes in skin temperature and changes in overall neuromuscular activation for vastus lateralis was observed (r<-0.5 and p<0.04). Significant positive relationship was observed between skin temperature and low frequency components of neuromuscular activation from vastus lateralis (r>0.7 and p<0.01). Participants with larger overall activation and reduced low frequency component for vastus lateralis activation presented a better adaptive response of their thermoregulatory system by showing fewer changes in skin temperature after incremental cycling test. PMID:25660627

  4. Body temperature and physical activity correlates of the menstrual cycle in Chacma Baboons (Papio hamadryas ursinus).

    PubMed

    Nyakudya, Trevor T; Fuller, Andrea; Meyer, Leith C R; Maloney, Shane K; Mitchell, Duncan

    2012-12-01

    We investigated the temporal relationship between abdominal temperature, physical activity, perineal swelling, and urinary progesterone and estradiol concentrations over the menstrual cycle in unrestrained captive baboons. Using a miniature temperature-sensitive data logger surgically implanted in the abdominal cavity and an activity data logger implanted subcutaneously on the trunk, we measured, continuously over 6 months at 10-min intervals, abdominal temperature and physical activity patterns in four female adult baboons Papio hamadryas ursinus (12.9-19.9 kg), in cages in an indoor animal facility (22-25°C). We monitored menstrual bleeding and perineal swelling changes, and measured urinary progesterone and estradiol concentrations, daily for up to 6 months, to ascertain the stage and length of the menstrual cycle. The menstrual cycle was 36 ± 2 days (mean ± SD) long and the baboons exhibited cyclic changes in perineal swellings, abdominal temperature, physical activity, urinary progesterone, and estradiol concentrations over the cycle. Mean 24-hr abdominal temperature during the luteal phase was significantly higher than during the periovulatory phase (ANOVA, F((2, 9)) = 4.7; P = 0.04), but not different to that during the proliferative phase. Physical activity followed a similar pattern, with mean 24-hr physical activity almost twice as high in the luteal than in the periovulatory phase (ANOVA, P = 0.58; F((2, 12)) = 5.8). We have characterized correlates of the menstrual cycle in baboons and shown, for the first time, a rhythm of physical activity and abdominal temperature over the menstrual cycle, with a nadir of temperature and activity at ovulation. PMID:22930453

  5. Tubulin dynamics during the cytoplasmic cohesiveness cycle in artificially activated sea urchin eggs.

    PubMed

    Coffe, G; Foucault, G; Raymond, M N; Pudles, J

    1983-12-01

    Sedimentation studies and [3H]colchicine-binding assays have demonstrated a relationship between the cytoplasmic cohesiveness cycles and the changes in tubulin organization in Paracentrotus lividus eggs activated by 2.5 mM procaine. The same amount of tubulin (20-25% of the total egg tubulin) is involved in these cyclic process and appears to undergo polymerization and depolymerization cycles. Electron microscopy studies reveal that the microtubules formed during these cytoplasmic cohesiveness cycles are under a particulate form which is sedimentable at low speed. Activation experiments carried out in the presence of cytochalasin B (CB) show that the increase in the cytoplasmic cohesiveness is highly reduced while tubulin polymerization and depolymerization cycles and pronuclear centration are not affected. Although tubulin or actin polymerization can be independently triggered in procaine-activated eggs, the increase in cytoplasmic cohesiveness requires the polymerization of both proteins. However, the cytoplasmic cohesiveness cycles appear to be regulated by tubulin polymerization and depolymerization cycles. PMID:6641809

  6. DISTRIBUTION OF FORCED VITAL CAPACITY AND FORCED EXPIRATORY VOLUME IN ONE SECOND IN CHILDREN 6 TO 11 YEARS OF AGE

    EPA Science Inventory

    The authors analyzed 44,664 annual measurements of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) in 12,258 white children and 1,041 black children between 6 and 11 years of age in 6 communities. Sex and race-specific lung function development is de...

  7. Effect of Ball Mass on Dribble, Pass, and Pass Reception in 9-11-Year-Old Boys' Basketball

    ERIC Educational Resources Information Center

    Arias, Jose L.; Argudo, Francisco M.; Alonso, Jose I.

    2012-01-01

    The objective of the study was to analyze the effect of ball mass on dribble, pass, and pass reception in real game situations in 9-11-year-old boys' basketball. Participants were 54 boys identified from six federated teams. The independent variable was ball mass, and dependent variables were number of dribbles, passes, and pass receptions. Three…

  8. Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children

    ERIC Educational Resources Information Center

    Devine, Paula; Lloyd, Katrina

    2012-01-01

    This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

  9. Comparative Analysis of Musical Abilities of 11-Year-Olds from Slovenia and the Island of Martinique

    ERIC Educational Resources Information Center

    Jerman, Janez; Pretnar, Tatjana

    2006-01-01

    The focus of the study is the comparison between the musical abilities of 11-year-old children on the island of Martinique and in Slovenia, and finding out to what extent their development of musical abilities is influenced by musical and cultural family background, music school attendance, choral singing and playing orchestral instruments. Our…

  10. Maximal Voluntary Static Force Production Characteristics of Skeletal Muscle in Children 8-11 Years of Age.

    ERIC Educational Resources Information Center

    Going, Scott B.; And Others

    1987-01-01

    A study of maximal voluntary isometric muscle contraction force-time curves among 32 normal, healthy 8- to 11-year-olds performing tasks involving separate muscle groups found that force and maximal rate of force increase were quite reproducible, but time to selected force levels reflected considerable variations. (Author/CB)

  11. Testing Effectiveness of a Community-Based Aggression Management Program for Children 7 to 11 Years Old and Their Families.

    ERIC Educational Resources Information Center

    Lipman, Ellen L.; Boyle, Michael H.; Cunningham, Charles; Kenny, Meghan; Sniderman, Carrie; Duku, Eric; Mills, Brenda; Evans, Peter; Waymouth, Marjorie

    2006-01-01

    Objective: There are few well-evaluated uncomplicated community-based interventions for childhood aggression. The authors assess the impact of a community-based anger management group on child aggressive behaviors, using a randomized, controlled trial (RCT). Method: Families with children 7 to 11 years old were recruited through advertisements and…

  12. Expectations and Levels of Understanding When Using Mobile Phones among 9-11-Year Olds in Wales, UK

    ERIC Educational Resources Information Center

    Turley, Joanne; Baker, Sally-Ann; Lewis, Christopher Alan

    2014-01-01

    There is growing interest in examining the use of mobile technology among children. The present study extended this literature among a sample of 9-11-year olds in Wales, UK in three ways. First, to examine the level of mobile phone ownership; second, to consider how mobile phones are used, investigate timescales and expectations when communicating…

  13. Element pool changes within a scrub-oak ecosystem after 11 years of elevated CO2 exposure

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Elevated CO2 effects on soil element pool size and fluxes are equivocal. We measured above and belowground pools of non-nitrogen macro and micronutrients in a Florida scrub-oak ecosystem exposed to twice-ambient CO2 concentrations for 11 years. We quantified element pools in above ground biomass of ...

  14. An Evaluation of Computerised Essay Marking for National Curriculum Assessment in the UK for 11-Year-Olds

    ERIC Educational Resources Information Center

    Hutchison, Dougal

    2007-01-01

    This paper reports a comparison of human and computer marking of approximately 600 essays produced by 11-year-olds in the UK. Each essay script was scored by three human markers. Scripts were also scored by the "e-rater" program. There was a good agreement between human and machine marking. Scripts with highly discrepant scores were flagged and…

  15. Discovery of an activity cycle in the solar analog HD 45184. Exploring Balmer and metallic lines as activity proxy candidates

    NASA Astrophysics Data System (ADS)

    Flores, M.; González, J. F.; Jaque Arancibia, M.; Buccino, A.; Saffe, C.

    2016-05-01

    Context. Most stellar activity cycles similar to that found in the Sun have been detected by using the chromospheric Ca ii H&K lines as stellar activity proxies. However, it is unclear whether such activity cycles can be identified using other optical lines. Aims: We aim to detect activity cycles in solar-analog stars and determine whether they can be identified through other optical lines, such as Fe II and Balmer lines. We study the solar-analog star HD 45184 using HARPS spectra. The temporal coverage and high quality of the spectra allow us to detect both long- and short-term activity variations. Methods: We analysed the activity signatures of HD 45184 by using 291 HARPS spectra obtained between 2003 and 2014. To search for line-core flux variations, we focused on Ca ii H&K and Balmer Hα and Hβ lines, which are typically used as optical chromospheric activity indicators. We calculated the HARPS-S index from Ca ii H&K lines and converted it into the Mount Wilson scale. In addition, we also considered the equivalent widths of Balmer lines as activity indicators. Moreover, we analysed the possible variability of Fe ii and other metallic lines in the optical spectra. The spectral variations were analysed for periodicity using the Lomb-Scargle periodogram. Results: We report for the first time a long-term 5.14-yr activity cycle in the solar-analog star HD 45184 derived from Mount Wilson S index. This makes HD 45184 one of most similar stars to the Sun with a known activity cycle. The variation is also evident in the first lines of the Balmer series, which do not always show a correlation with activity in solar-type stars. Notably, unlike the solar case, we also found that the equivalent widths of the high photospheric Fe ii lines (4924 Å, 5018 Å and 5169 Å) are modulated (±2 mÅ) by the chromospheric cycle of the star. These metallic lines show variations above 4σ in the rms spectrum, while some Ba ii and Ti ii lines present variations at 3σ level, which

  16. Sex-dependent activity of the spinal excitatory amino acid transporter: Role of estrous cycle.

    PubMed

    Sajjad, Jahangir; Felice, Valeria D; Golubeva, Anna V; Cryan, John F; O'Mahony, Siobhain M

    2016-10-01

    Females are more likely to experience visceral pain than males, yet mechanisms underlying this sex bias are not fully elucidated. Moreover, pain sensitivity can change throughout the menstrual cycle. Alterations in the glutamatergic system have been implicated in several pain-disorders; however, whether these are sex-dependent is unclear. Thus, we aimed to investigate sex differences in the spinal cord glutamate uptake and how it varies across the estrous cycle. The activity of the glutamate transporters, excitatory amino acid transporters (EAATs) was assessed using an ex vivo aspartate radioactive uptake assay in the lumbosacral spinal cord in Sprague-Dawley male and female rats. The gene expression of EAATs, glutamate receptor subunits NR1 and NR2B and the estrogen receptors ERα & ERβ in the spinal cord were also analyzed. EAAT activity was lower in females, particularly during the estrus phase, and this was the only cycle stage that was responsive to the pharmacological effects of the EAATs activator riluzole. Interestingly, EAAT1 mRNA expression was lower in high-estrogen and high-ERα states compared to diestrus in females. We conclude that the Spinal EAAT activity in females is different to that in males, and varies across the estrous cycle. Furthermore, the expression levels of estrogen receptors also showed a cycle-dependent pattern that may affect EAATs function and expression. PMID:27471194

  17. Low-intensity cycling affects the muscle activation pattern of consequent countermovement jumps.

    PubMed

    Marquez, Gonzalo J; Mon, Javier; Acero, Rafael M; Sanchez, Jose A; Fernandez-del-Olmo, Miguel

    2009-08-01

    Players (eg, basketball, soccer, and football) often use a static bicycle during a game to maintain warming. However, the effectiveness of this procedure has not been addressed in the literature. Thus, it remains unknown whether low-intensity cycling movement can affect explosive movement performance. In this study, 10 male subjects performed countermovement jumps before and after a 15-minutes cycling bout at 35% of their maximal power output. Three sessions were tested for 3 different cadences of cycling: freely chosen cadence, 20% lower than freely chosen cadence (FCC-20%), and 20% higher than freely chosen cadence (FCC+20%). Jump height, kinematics, and electromyogram were recorded simultaneously during the countermovement jumps. The results showed a significant decreasing in the height of countermovement jump after cycling at freely chosen cadence and FCC-20% (p = 0.03 and p = 0.04, respectively), but not for FCC+20% cadences. The electromyographic parameters suggest that changes in the countermovement jump after cycling can be attributed to alteration of the pattern of activation and may be modulated by the preceding cycling cadence. Our study indicates that to avoid a possible negative effect of the cycling in the subsequent explosive movements, a cadence 20% higher than the preferred cadence must be used. PMID:19620918

  18. The effect of physical activity across the menstrual cycle on reproductive function

    PubMed Central

    Ahrens, Katherine A.; Vladutiu, Catherine J.; Mumford, Sunni L.; Schliep, Karen C.; Perkins, Neil J.; Wactawski-Wende, Jean; Schisterman, Enrique F.

    2013-01-01

    Purpose To evaluate the association between physical activity (PA) across the menstrual cycle and reproductive function. Methods The BioCycle Study (2005–2007) followed 259, healthy premenopausal women not using hormonal contraceptives for up to two menstrual cycles (N=509 cycles). Serum leptin, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and testosterone were measured five to eight times per cycle. Linear mixed models were used to estimate the effect of past-week PA (measured four times during each cycle) on hormone levels. Past-week PA was categorized into tertiles based on metabolic equivalent [MET]-h/week (cut-points were 15.3 and 35.7). Risk ratios for sporadic anovulation were estimated using generalized linear models. Analyses adjusted for habitual PA (assessed at baseline), body mass index, race, age, and perceived stress. Linear mixed models used inverse probability weights to control for concurrent reproductive hormones and caloric intake. Results High past-week PA was inversely associated with leptin (−6.6%, 95% confidence interval [−10.6, −2.5]) and luteal phase progesterone (−22.1% [−36.2, −4.7]) as compared with low past-week PA. High past-week PA was not significantly associated with sporadic anovulation (adjusted risk ratio=1.5 [0.6, 3.4]). Conclusions High levels of PA were modestly associated with changes in select hormones, but not sporadic anovulation among moderate to highly active premenopausal women. PMID:24345590

  19. A New Component of Solar Dynamics: North-South Diverging Flows Migrating toward the Equator with an 11 Year Period

    NASA Technical Reports Server (NTRS)

    Beck, J. G.; Gizon, L.; Duvall, Thomas L., Jr.; Oegerle, William R. (Technical Monitor)

    2002-01-01

    Time-distance helioseismology analysis of dopplergrams provides maps of torsional oscillations and meridional flows. Meridional flow maps show a time-varying component that has a banded structure which matches the torsional oscillations with an equatorward migration over the solar cycle. The time-varying component of meridional flow consists of a flow diverging from the dominant latitude of magnetic activity. These maps are compared with other torsional oscillation maps and with magnetic flux maps, showing a strong correlation with active latitudes. These results demonstrate a strong link between the time-varying component of the meridional flow and the torsional oscillations.

  20. 11 Years of Cloud Characteristics from SEVIRI: 2nd Edition of the CLAAS Dataset by CMSAF

    NASA Astrophysics Data System (ADS)

    Finkensieper, Stephan; Stengel, Martin; Fokke Meirink, Jan; van Zadelhoff, Gerd-Jan; Kniffka, Anke

    2016-04-01

    Spatiotemporal variability of clouds is an important aspect of the climate system. Therefore climate data records of cloud properties are valuable to many researchers in the climate community. The passive SEVIRI imager onboard the geostationary Meteosat Second Generation satellites is well suited for the needs of cloud retrievals as it provides measurements in 12 spectral channels every 15 minutes and thus allows for capturing both the spatial and the temporal variability of clouds. However, requirements on climate data records are high in terms of record length and homogeneity, so that intercalibration and homogenization among the available SEVIRI instruments becomes a crucial factor. We present the 2nd edition of the CLoud Property DAtAset using SEVIRI (CLAAS-2) generated within the EUMETSAT Satellite Application Facility on Climate Monitoring (CMSAF), that is temporally extended and qualitatively improved compared to the 1st edition. CLAAS-2 covers the time period 2004-2014 and features cloud mask, cloud top properties, cloud phase, cloud type, and microphysical cloud properties on the complete SEVIRI disc in 15-minute temporal resolution. Temporally and spatially averaged quantities, mean diurnal cycles and monthly histograms are included as well. CLAAS-2 was derived from a homogenized data basis, obtained by intercalibrating visible and infrared SEVIRI radiances (of Meteosat 8, 9 and 10) with MODIS, using state-of-the-art retrieval schemes. In addition to the dataset characteristics, we will present validation results using CALIPSO as reference observations. The CLAAS-2 dataset will allow for a large variety of applications of which some will be indicated in our presentation, with focus on determining diurnal to seasonal cycles, spatially resolved frequencies of cloud properties as well as showing the potential for using CLAAS-2 data for model process studies.

  1. Effects of physical activity on pupil cycle time (PCT) in healthy Indian male.

    PubMed

    Ghosh, Suparna; Avadhany, Sandhya T

    2014-01-01

    Globally, physical inactivity is an important risk factor for the development of non-communicable disease consisting of coronary artery disease, as well as, other diseases including hypertension, diabetes, obesity, osteoporosis, and certain types of cancers. Parasympathetic nervous system (PNS) activity in the eye is determined by the pupil cycle time (PCT) can be comparable with cardiac parasympathetic response and thereby determine the morbidity and mortality among individuals. The PCT is measured by throwing white light on the edge of the pupil. Pupil cycling is a feature of pupillary reflex arc. The aim of this study is to establish the effect of physical activity on the PCT. The counting of PCT was done for 90 cycles and average one count is considered a single PCT. The physical activity level (PAL) was determined by administering a physical activity level questionnaire developed in the Division of Nutrition, St. John's Medical College, Bangalore. The PAL is classified as < 1.4 as sedentary, 1.55 to 1.75 moderately active, and > 1.75 heavily active. Thirty healthy male volunteers in the age group of 18-50 years and with BMI of 18.5 kg/m2-30 kg/m2 were studied. We obtained PCT of 962.00 ± 105.72 msec in sedentary, 896.77 ± 85.88 msec in moderately active and 889.45 ± 68.71 msec in heavily active individuals. Linear regression analysis shows there is statistically significant difference between the three different groups of physical activity level with a b value of 0 and R2 being 0.19. Increase in physical activity led to decrease in the PCT i.e. increase in the parasympathetic tone in the eye. Pupil cycle time (PCT) is a simple noninvasive tool to assess and differentiate the PNS function in different activity level of individual. PMID:25906609

  2. Impact of New Transport Infrastructure on Walking, Cycling, and Physical Activity

    PubMed Central

    Panter, Jenna; Heinen, Eva; Mackett, Roger; Ogilvie, David

    2016-01-01

    Introduction Walking and cycling bring health and environmental benefits, but there is little robust evidence that changing the built environment promotes these activities in populations. This study evaluated the effects of new transport infrastructure on active commuting and physical activity. Study design Quasi-experimental analysis nested within a cohort study. Setting/participants Four hundred and sixty-nine adult commuters, recruited through a predominantly workplace-based strategy, who lived within 30 kilometers of Cambridge, United Kingdom and worked in areas of the city to be served by the new transport infrastructure. Intervention The Cambridgeshire Guided Busway opened in 2011 and comprised a new bus network and a traffic-free walking and cycling route. Exposure to the intervention was defined using the shortest distance from each participant’s home to the busway. Main outcome measures Change in weekly time spent in active commuting between 2009 and 2012, measured by validated 7-day recall instrument. Secondary outcomes were changes in total weekly time spent walking and cycling and in recreational and overall physical activity, measured using the validated Recent Physical Activity Questionnaire. Data were analyzed in 2014. Results In multivariable multinomial regression models—adjusted for potential sociodemographic, geographic, health, and workplace confounders; baseline active commuting; and home or work relocation—exposure to the busway was associated with a significantly greater likelihood of an increase in weekly cycle commuting time (relative risk ratio=1.34, 95% CI=1.03, 1.76) and with an increase in overall time spent in active commuting among the least active commuters at baseline (relative risk ratio=1.76, 95% CI=1.16, 2.67). The study found no evidence of changes in recreational or overall physical activity. Conclusions Providing new sustainable transport infrastructure was effective in promoting an increase in active commuting. These

  3. [The development of the activity-rest cycle in the rabbit fetus].

    PubMed

    Belich, A I; Nazarova, L A

    1988-01-01

    On 25-30-day rabbit foetuses, in chronic experiments using constant synchronous recording of the motor activity and heart rate, studies have been made of temporal organization of the activity-rest cycle. Already in 25-day foetus, three functional conditions may be distinguished: active, intermediate and resting ones, the duration of the latter increasing to the end of gestation up to 8-10 min, whereas the duration of the intermediate phase decreases, reaching its minimum to the 30th day if not being completely reduced. Cyclic pattern of active and resting phases is observed in 28-day foetuses; to the 29th-30th day, these phases from a unique activity-rest cycle, its duration reaching 20-30 min to the end of intrauterine period. It is suggested that the resting phase in foetal rabbits serves as a basis for the development of polyphasic sleep in adult animals. PMID:3414220

  4. Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome

    PubMed Central

    Stickford, Abigail SL; VanGundy, Tiffany B; Levine, Benjamin D; Fu, Qi

    2015-01-01

    Abstract Patients with the postural orthostatic tachycardia syndrome (POTS) are primarily premenopausal women, which may be attributed to female sex hormones. We tested the hypothesis that hormonal fluctuations of the menstrual cycle alter sympathetic neural activity and orthostatic tolerance in POTS women. Ten POTS women were studied during the early follicular (EF) and mid-luteal (ML) phases of the menstrual cycle. Haemodynamics and muscle sympathetic nerve activity (MSNA) were measured when supine, during 60 deg upright tilt for 45 min or until presyncope, and during the cold pressor test (CPT) and Valsalva manoeuvres. Blood pressure and total peripheral resistance were higher during rest and tilting in the ML than EF phase; however, heart rate, stroke volume and cardiac output were similar between phases. There were no mean ± SD differences in MSNA burst frequency (8 ± 8 EF phase vs. 10 ± 10 bursts min–1 ML phase at rest; 34 ± 15 EF phase vs. 36 ± 16 bursts min–1 ML phase at 5 min tilt), burst incidence or total activity, nor any differences in the cardiovagal and sympathetic baroreflex sensitivities between phases under any condition. The incidence of presyncope was also the same between phases. There were no differences in haemodynamic or sympathetic responses to CPT or Valsalva. These results suggest that the menstrual cycle does not affect sympathetic neural activity but modulates blood pressure and vasoconstriction in POTS women during tilting. Thus, factors other than sympathetic neural activity are probably responsible for the symptoms of orthostatic intolerance across the menstrual cycle in women with POTS. Key points Women with the postural orthostatic tachycardia syndrome (POTS) report fluctuations in orthostatic tolerance throughout the menstrual cycle. The mechanism(s) underlying blood pressure control across the menstrual cycle in women with POTS are unknown. The findings of the present study indicate that the menstrual

  5. Solar Magnetic Activity Cycles, Coronal Potential Field Models and Eruption Rates

    NASA Astrophysics Data System (ADS)

    Petrie, G. J. D.

    2013-05-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the National Solar Observatory's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun vector spectro-magnetograph, the spectro-magnetograph and the 512-channel magnetograph instruments, and from Stanford University's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Polar field changes are found to be well correlated with active fields over most of the period studied, except between 2003 and 2006 when the active fields did not produce significant polar field changes. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The tilt of the solar dipole is therefore almost entirely due to active-region fields. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking, Solar Eruptive Event Detection System, and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003 and 2012 than for those between 1997 and 2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  6. Estradiol levels modulate brain activity and negative responses to psychosocial stress across the menstrual cycle.

    PubMed

    Albert, Kimberly; Pruessner, Jens; Newhouse, Paul

    2015-09-01

    Although ovarian hormones are thought to have a potential role in the well-known sex difference in mood and anxiety disorders, the mechanisms through which ovarian hormone changes contribute to stress regulation are not well understood. One mechanism by which ovarian hormones might impact mood regulation is by mediating the effect of psychosocial stress, which often precedes depressive episodes and may have mood consequences that are particularly relevant in women. In the current study, brain activity and mood response to psychosocial stress was examined in healthy, normally cycling women at either the high or low estradiol phase of the menstrual cycle. Twenty eight women were exposed to the Montreal Imaging Stress Task (MIST), with brain activity determined through functional magnetic resonance imaging, and behavioral response assessed with subjective mood and stress measures. Brain activity responses to psychosocial stress differed between women in the low versus high estrogen phase of the menstrual cycle: women with high estradiol levels showed significantly less deactivation in limbic regions during psychosocial stress compared to women with low estradiol levels. Additionally, women with higher estradiol levels also had less subjective distress in response to the MIST than women with lower estradiol levels. The results of this study suggest that, in normally cycling premenopausal women, high estradiol levels attenuate the brain activation changes and negative mood response to psychosocial stress. Normal ovarian hormone fluctuations may alter the impact of psychosocially stressful events by presenting periods of increased vulnerability to psychosocial stress during low estradiol phases of the menstrual cycle. This menstrual cycle-related fluctuation in stress vulnerability may be relevant to the greater risk for affective disorder or post-traumatic stress disorder in women. PMID:26123902

  7. Corticospinal contributions to lower limb muscle activity during cycling in humans.

    PubMed

    Sidhu, Simranjit K; Hoffman, Ben W; Cresswell, Andrew G; Carroll, Timothy J

    2012-01-01

    The purpose of the current study was to investigate corticospinal contributions to locomotor drive to leg muscles involved in cycling. We studied 1) if activation of inhibitory interneurons in the cortex via subthreshold transcranial magnetic stimulation (TMS) caused a suppression of EMG and 2) how the responses to stimulation of the motor cortex via TMS and cervicomedullary stimulation (CMS) were modulated across the locomotor cycle. TMS at intensities subthreshold for activation of the corticospinal tract elicited suppression of EMG for approximately one-half of the subjects and muscles during cycling, and in matched static contractions in vastus lateralis. There was also significant modulation in the size of motor-evoked potentials (MEPs) elicited by TMS across the locomotor cycle (P < 0.001) that was strongly related to variation in background EMG in all muscles (r > 0.86; P < 0.05). When MEP and CMEP amplitudes were normalized to background EMG, they were relatively larger prior to the main EMG burst and smaller when background EMG was maximum. Since the pattern of modulation of normalized MEP and CMEP responses was similar, the data suggest that phase-dependent modulation of corticospinal responses during cycling in humans is driven mainly by spinal mechanisms. However, there were subtle differences in the degree to which normalized MEP and CMEP responses were facilitated prior to EMG burst, which might reflect small increases in cortical excitability prior to maximum muscle activation. The data demonstrate that the motor cortex contributes actively to locomotor drive, and that spinal factors dominate phase-dependent modulation of corticospinal excitability during cycling in humans. PMID:22013236

  8. Self-reported sleep patterns, sleep problems, and behavioral problems among school children aged 8-11 years.

    PubMed

    Hoedlmoser, K; Kloesch, G; Wiater, A; Schabus, M

    2010-03-01

    OBJECTIVES: Investigation of sleep patterns, sleep problems, and behavioral problems in 8- to 11-year-old children. METHODS: A total of 330 children (age: M=9.52; SD=0.56; range=8-11 years; 47.3% girls) in the 4th grade of elementary school in Salzburg (Austria) completed a self-report questionnaire (80 items) to survey sleep patterns, sleep problems, and behavioral problems. RESULTS: Children aged 8-11 years slept approximately 10 h and 13 min on school days (SD=47 min) as well as on weekends (SD=81 min); girls slept significantly longer on weekends than boys. Most common self-reported sleep problems were dryness of the mouth (26.6%), sleep onset delay (21.9%), bedtime resistance (20.3%), and restless legs (19.4%). There was a significant association between watching TV as well as playing computer games prior to sleep with frightful dreams. Daytime sleepiness indicated by difficulty waking up (33.4%) and having a hard time getting out of bed (28.5%) was also very prominent. However, children in Salzburg seemed to be less tired during school (6.6%) or when doing homework (4.8%) compared to other nationalities. Behavioral problems (e.g., emotional symptoms, hyperactivity and inattention, conduct problems, peer problems) and daytime sleepiness were both significantly associated with sleep problems: the more sleep problems reported, the worse behavioral problems and daytime sleepiness were. Moreover, we could show that sharing the bed with a pet was also related to sleep problems. CONCLUSIONS: Self-reported sleep problems among 8- to 11-year-old children are very common. There is a strong relationship between sleep disorders and behavioral problems. Routine screening and diagnosis as well as treatment of sleep disorders in school children should, therefore, be established in the future. PMID:23162377

  9. Blue Sky Below My Feet: Daycamp & After School Programs--9 to 11 Year Olds. Leader's Manual.

    ERIC Educational Resources Information Center

    California Univ., Berkeley. Cooperative Extension Service.

    This manual presents a 10-day lesson plan for day camp and after-school program leaders. The activities and experiments described in the manual focus on nutrition and space exploration. Topics covered by the lesson plan and specific projects include: (1) gravity; (2) food spoilage; (3) model rocket building and launching; (4) the basic food…

  10. Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.

    PubMed

    Serebrov, V Yu; Kuzmenko, D I; Burov, P G; Novitsky, S V

    2008-12-01

    Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed. PMID:19513367

  11. US Activities in Making Life Cycle Inventory Data More Available to Users

    EPA Science Inventory

    The demand for LCA studies continues to grow, although, the lack of reliable, transparent Life Cycle Inventory (LCI) data is hampering the wide-spread application of LCA. This paper will present activities related to the development and accessibility of process LCI data in the U...

  12. The Development of a New Practical Activity: Using Microorganisms to Model Gas Cycling

    ERIC Educational Resources Information Center

    Redfern, James; Burdass, Dariel; Verran, Joanna

    2014-01-01

    For many in the school science classroom, the term "microbiology" has become synonymous with "bacteriology". By overlooking other microbes, teachers may miss out on powerful practical tools. This article describes the development of an activity that uses algae and yeast to demonstrate gas cycling, and presents full instructions…

  13. Solar activity cycle and the incidence of foetal chromosome abnormalities detected at prenatal diagnosis

    NASA Astrophysics Data System (ADS)

    Halpern, Gabrielle J.; Stoupel, Eliahu G.; Barkai, Gad; Chaki, Rina; Legum, Cyril; Fejgin, Moshe D.; Shohat, Mordechai

    1995-06-01

    We studied 2001 foetuses during the period of minimal solar activity of solar cycle 21 and 2265 foetuses during the period of maximal solar activity of solar cycle 22, in all women aged 37 years and over who underwent free prenatal diagnosis in four hospitals in the greater Tel Aviv area. There were no significant differences in the total incidence of chromosomal abnormalities or of trisomy between the two periods (2.15% and 1.8% versus 2.34% and 2.12%, respectively). However, the trend of excessive incidence of chromosomal abnormalities in the period of maximal solar activity suggests that a prospective study in a large population would be required to rule out any possible effect of extreme solar activity.

  14. Analytical Study of Geomagnetic and Solar Activities During Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Hady, A. A.

    The data of amplitude and phase of most common indicators of geomagnetic activities (especially aa index, A? index) have been analyzed and compared with the solar ac- tivities in the time of solar cycle 23(started from 1996 to 2007). The data taken from NOAA space environment center (SES), USA. during the period starting April 1996 Until Dec. 2001, have been analyzed by power spectrum method. The prediction until year 2007 of geomagnetic activities were studied according to the whole of behavior of solar cycle 23. The results show a good indication of the effects of solar activities on changes of earth climate and weather forecasting. The results are important to various techniques including the operation of low earth orbiting satellites. The climatologi- cal approach makes use of the secular trend since year 1900 until now, by about 15 nanotesla. This indication was recorded too, in solar activity changes during the last century.

  15. Changes in element contents of four lichens over 11 years in the Boundary Waters Canoe Area Wilderness, northern Minnesota

    USGS Publications Warehouse

    Bennett, J.P.; Wetmore, C.M.

    1999-01-01

    Four species of lichen (Cladina rangiferina, Evernia mesomorpha, Hypogymnia physodes, and Parmelia sulcata) were sampled at six locations in the Boundary Waters Canoe Area Wilderness three times over a span of 11 years and analyzed for concentrations of 16 chemical elements to test the hypotheses that corticolous species would accumulate higher amounts of chemical elements than terricolous species, and that 11 years were sufficient to detect spatial patterns and temporal trends in element contents. Multivariate analyses of over 2770 data points revealed two principal components that accounted for 68% of the total variance in the data. These two components, the first highly loaded with Al, B, Cr, Fe, Ni and S, and the second loaded with Ca, Cd, Mg and Mn, were inversely related to each other over time and space. The first component was interpreted as consisting of an anthropogenic and a dust component, while the second, primarily a nutritional component. Cu, K, Na, P, Pb and Zn were not highly loaded on either component. Component 1 decreased significantly over the 11 years and from west to east, while component 2 increased. The corticolous species were more enriched in heavy metals than the terricolous species. All four elements in component 2 in H. physodes were above enrichment thresholds for this species. Species differences on the two components were greater than the effects of time and space, suggesting that biomonitoring with lichens is strongly species dependent. Some localities in the Boundary Waters Canoe Area Wilderness appear enriched in some anthropogenic elements for no obvious reasons.

  16. Limit cycle analysis of active disturbance rejection control system with two nonlinearities.

    PubMed

    Wu, Dan; Chen, Ken

    2014-07-01

    Introduction of nonlinearities to active disturbance rejection control algorithm might have high control efficiency in some situations, but makes the systems with complex nonlinearity. Limit cycle is a typical phenomenon that can be observed in the nonlinear systems, usually causing failure or danger of the systems. This paper approaches the problem of the existence of limit cycles of a second-order fast tool servo system using active disturbance rejection control algorithm with two fal nonlinearities. A frequency domain approach is presented by using describing function technique and transfer function representation to characterize the nonlinear system. The derivations of the describing functions for fal nonlinearities and treatment of two nonlinearities connected in series are given to facilitate the limit cycles analysis. The effects of the parameters of both the nonlinearity and the controller on the limit cycles are presented, indicating that the limit cycles caused by the nonlinearities can be easily suppressed if the parameters are chosen carefully. Simulations in the time domain are performed to assess the prediction accuracy based on the describing function. PMID:24795034

  17. Microbial activities and phosphorus cycling: An application of oxygen isotope ratios in phosphate

    NASA Astrophysics Data System (ADS)

    Stout, Lisa M.; Joshi, Sunendra R.; Kana, Todd M.; Jaisi, Deb P.

    2014-08-01

    Microorganisms carry out biochemical transformations of nutrients that make up their cells. Therefore, understanding how these nutrients are transformed or cycled in natural environments requires knowledge of microbial activity. Commonly used indicators for microbial activity typically include determining microbial respiration by O2/CO2 measurements, cell counts, and measurement of enzyme activities. However, coupled studies on nutrient cycling and microbial activity are not given enough emphasis. Here we apply phosphate oxygen isotope ratios (δ18OP) as a tool for measurement of microbial activity and compare the rate of isotope exchange with methods of measuring microbial activities that are more commonly applied in environmental studies including respiration, dehydrogenase activity, alkaline phosphatase activity, and cell counts. Our results show that different bacteria may have different strategies for P uptake, storage and release, their respiration and consequently expression of DHA and APase activities, but in general the trend of their enzyme activities are comparable. Phosphate δ18OP values correlated well with these other parameters used to measure microbial activity with the strongest linear relationships between δ18OP and CO2 evolution (r = -0.99). Even though the rate of isotope exchange for each microorganism used in this study is different, the rate per unit CO2 respiration showed one general trend, where δ18OP values move towards equilibrium while CO2 is generated. While this suggests that P cycling among microorganisms used in this study can be generalized, further research is needed to determine whether the microorganism-specific isotope exchange trend may occur in natural environments. In summary, phosphate oxygen isotope measurements may offer an alternative for use as a tracer to measure microbial activity in soils, sediments, and many other natural environments.

  18. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.

    PubMed

    Patterson, Rainey E; Kalavalapalli, Srilaxmi; Williams, Caroline M; Nautiyal, Manisha; Mathew, Justin T; Martinez, Janie; Reinhard, Mary K; McDougall, Danielle J; Rocca, James R; Yost, Richard A; Cusi, Kenneth; Garrett, Timothy J; Sunny, Nishanth E

    2016-04-01

    The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high-trans-fat high-fructose diet (TFD) for 8 wk to induce simple steatosis and NASH by 24 wk. In vivo fasting hepatic mitochondrial fluxes were determined by(13)C-nuclear magnetic resonance (NMR)-based isotopomer analysis. Hepatic metabolic intermediates were quantified using mass spectrometry-based targeted metabolomics. Hepatic triglyceride accumulation and insulin resistance preceded alterations in mitochondrial metabolism, since TCA cycle fluxes remained normal during simple steatosis. However, mice with NASH had a twofold induction (P< 0.05) of mitochondrial fluxes (μmol/min) through the TCA cycle (2.6 ± 0.5 vs. 5.4 ± 0.6), anaplerosis (9.1 ± 1.2 vs. 16.9 ± 2.2), and pyruvate cycling (4.9 ± 1.0 vs. 11.1 ± 1.9) compared with their age-matched controls. Induction of the TCA cycle activity during NASH was concurrent with blunted ketogenesis and accumulation of hepatic diacylglycerols (DAGs), ceramides (Cer), and long-chain acylcarnitines, suggesting inefficient oxidation and disposal of excess free fatty acids (FFA). Sustained induction of mitochondrial TCA cycle failed to prevent accretion of "lipotoxic" metabolites in the liver and could hasten inflammation and the metabolic transition to NASH. PMID:26814015

  19. Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle.

    PubMed

    Lewis, Robert; Curtis, J Thomas

    2016-03-15

    Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In humans, blood pressure decreases during the resting phase of the activity cycle, and the magnitude of that "nocturnal dipping" has been used to stratify patients according to the risk for cardiovascular disease. However, in contrast to most mammals, prairie voles (Microtus ochrogaster) have periods of activity and rest that follow an ultradian rhythm with period lengths significantly <24h. While rhythmic changes in blood pressure across a circadian activity cycle have been well-documented, blood pressure patterns in species that display ultradian rhythms in activity are less well-studied. In the current study, we implanted pressure-sensitive radiotelemetry devices in male prairie voles and recorded activity, mean arterial pressure (MAP), and heart rate (HR) continuously for 3days. Visualization of the ultradian rhythms was enhanced using a 1h running average to filter the dataset. Positive correlations were found between activity and MAP and between activity and HR. During the inactive period of the ultradian cycle, blood pressure decreased by about 15%, which parallels the nocturnal dipping pattern seen in healthy humans. Further, the duration of inactivity did not affect any of the cardiovascular measures, so the differences in blood pressure values between the active and inactive periods are likely driven by ultradian oscillations in hormones and autonomic function. Finally, specific behavioral patterns also were examined. Both the instrumented animal and his non-instrumented cagemate appeared to show synchronized activity patterns, with both animals displaying sleep-like behavior for more than 90% of the inactive period. We propose that the prairie vole ultradian rhythm in blood pressure is an analogue for circadian blood pressure variability

  20. Study of intensive solar flares in the rise phase of solar cycle 23 and 24 and other activities

    NASA Astrophysics Data System (ADS)

    Subramanian, S. Prasanna; Shanmugaraju, A.

    2016-02-01

    We present a statistical study and comparison on the properties of intensive solar flares (>M5.0 X-ray flare), decameter-hectometric (DH) wavelength [frequency, 1-14 MHz] type II radio bursts and solar energetic particle (SEP) events during the rising phase of solar cycles 23 and 24. The period of study is May 1996-November 2000 for solar cycle 23 and December 2008-June 2013 for solar cycle 24. Apart from reported weakness of solar cycle 24 compared to the cycle 23, we noted the following differences between the two cycles on the properties of these activities associated with intensive flares: (i) The reduction in the number of intensive flares (>M5.0 class) in cycle 24 is ˜34 %, similar to the reduction in sunspot number reported by Gopalswamy et al. (2014a); (ii) The slightly higher mean starting-frequency (4.15 MHz) and lower ending frequency (0.58 MHz) in cycle 24 compared to those of cycle 23 (2.63 and 0.89 MHz, respectively) indicate that the radio emission of this cycle started closer to the Sun and the CME-shock travelled farther away from the Sun in cycle 24; (iv) Cycle 23 produced a nearly equal number of SEP events as cycle 24 during the rising phase. The correlation between SEP intensity and CME speed is more prominent in cycle 23 (CC=0.7) than in cycle 24 (CC=0.3).

  1. The sunspot cycle no. 24 in relation to long term solar activity variation

    PubMed Central

    Komitov, Boris; Kaftan, Vladimir

    2013-01-01

    The solar minimum between solar cycles 23 and 24 during the period 2007–2009 has been the longest and deepest one at least since for the last 100 years. We suggest that the Sun is going to his next supercenturial minimum. The main aim of this paper is to tell about arguments concerning this statement. They are based on series of studies, which have been provided during the period since 1997 up to 2010. The progress of solar cycle 24 since its minimum at the end of 2008 up to the end of October 2011 in the light of long term solar activity dynamics is analyzed. PMID:25685429

  2. The sunspot cycle no. 24 in relation to long term solar activity variation.

    PubMed

    Komitov, Boris; Kaftan, Vladimir

    2013-05-01

    The solar minimum between solar cycles 23 and 24 during the period 2007-2009 has been the longest and deepest one at least since for the last 100 years. We suggest that the Sun is going to his next supercenturial minimum. The main aim of this paper is to tell about arguments concerning this statement. They are based on series of studies, which have been provided during the period since 1997 up to 2010. The progress of solar cycle 24 since its minimum at the end of 2008 up to the end of October 2011 in the light of long term solar activity dynamics is analyzed. PMID:25685429

  3. Study of Distribution and Asymmetry of Solar Active Prominences during Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Joshi, Navin Chandra; Bankoti, Neeraj Singh; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2009-12-01

    In this article we present the results of a study of the spatial distribution and asymmetry of solar active prominences (SAP) for the period 1996 through 2007 (solar cycle 23). For more meaningful statistical analysis we analyzed the distribution and asymmetry of SAP in two subdivisions viz. Group1 (ADF, APR, DSF, CRN, CAP) and Group2 (AFS, ASR, BSD, BSL, DSD, SPY, LPS). The North - South (N - S) latitudinal distribution shows that the SAP events are most prolific in the 21° to 30° slice in the Northern and Southern Hemispheres; the East - West (E - W) longitudinal distribution study shows that the SAP events are most prolific (best observable) in the 81° to 90° slice in the Eastern and Western Hemispheres. It was found that the SAP activity during this cycle is low compared to previous solar cycles. The present study indicates that during the rising phase of the cycle the number of SAP events are roughly equal in the Northern and Southern Hemispheres. However, activity in the Southern Hemisphere has been dominant since 1999. Our statistical study shows that the N - S asymmetry is more significant then the E - W asymmetry.

  4. Stellar activity cycles from long-term data by robotic telescopes

    NASA Astrophysics Data System (ADS)

    Oláh, K.

    2014-03-01

    All results about stellar activity cycles stem from decades-long systematic observations that were done by small telescopes. Without these equipments we would not know much, if anything, about stellar activity cycles, like those we see and observe easily on the nearest star, the Sun. In the early 80's of the last century systematic photometric monitoring of active stars began with automated photometric telescopes (APTs), some of which continue the observations to date. The Vienna-Potsdam APT now works for about two decades (Strassmeier et al. 1997), similarly to the 4-College Consortium APT (Dukes et al. 1995), while the Catania APT (Rodono et al. 2001) was closed down a few years ago. These small tools with the same setups for decades do not cost much and are relatively cheap to maintain. The longest continuous photometric datasets of a few objects from APTs span now over 30 years, which, together with earlier, manually-obtained data allow to study those activity cycles of stars which are in the order of 10 years or shorter: to be sure in the timescale of a cycle it should be observed repeatedly at least 2-3 times. The spectroscopic automated telescope STELLA (Strassmeier et al. 2004), built in the first decade of this century, measured already a few dozens of radial velocity curves for long-period binary stars and measured their activity levels (Strassmeier et al. 2012); these results can be gathered only by robotic telescopes. Only with STELLA it is possible to study the decades-long behavior of starspots on active giants with long rotational periods via Doppler Imaging. As the databases were growing it became clear that stars, just as the Sun, had multiple cycles. It was also found that stellar cycles showed systematic changes and that the cycle lengths correlated with the rotational periods of the stars. Extensive summaries of stellar activity cycles are found in Baliunas et al. (1995) using the Mt. Wilson Ca-index survey, and Oláh et al. (2009) based on

  5. Solar magnetic activity cycles, coronal potential field models and eruption rates

    NASA Astrophysics Data System (ADS)

    Petrie, Gordon

    2013-07-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun (SOLIS) vector spectro-magnetograph (VSM), the spectro-magnetograph and the 512-channel magnetograph instruments, and from the U. Stanford's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking (CACTus), Solar Eruptive Event Detection System (SEEDS), and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003-2012 than for those between 1997-2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  6. Luteinizing hormone-releasing hormone fusion protein vaccines block estrous cycle activity in beef heifers.

    PubMed

    Stevens, J D; Sosa, J M; deAvila, D M; Oatley, J M; Bertrand, K P; Gaskins, C T; Reeves, J J

    2005-01-01

    Two LHRH fusion proteins, thioredoxin and ovalbumin, each containing seven LHRH inserts were tested for their ability to inhibit estrous cycle activity. The objective was to evaluate immune and biological responses from alternating the two fusion proteins in an immunization schedule. One hundred ten heifers were divided equally into 11 groups. Two control groups consisted of either spayed or intact, untreated heifers. Heifers in the other nine groups were immunized on wk 0, 4, and 9. Treatments were immunizations of the same protein throughout or alternating the proteins in different booster sequences. Blood was collected weekly for 22 wk, and serum was assayed for concentrations of progesterone and titers of anti-LHRH. At slaughter, reproductive tracts were removed from each heifer and weighed. Heifers with >or=1 ng/mL of progesterone were considered to have a functional corpus luteum and thus to have estrous cycle activity. All LHRH-immunized groups of heifers had a smaller (P < 0.05) proportion of heifers showing estrous cycle activity after 6 wk than the intact, untreated control group. There was no difference in number of heifers cycling between the immunized groups and the spayed heifers during wk 9 to 22. Anti-LHRH did not differ among immunized groups during wk 1 to 9. Starting at wk 10 and continuing through the conclusion of the study, there was an overall difference among treatment groups for anti-LHRH (P < 0.05). Uterine weights differed among treatments (P < 0.05), with intact control animals having heavier uteri than all other groups (P < 0.05). Uterine weights were negatively correlated with maximum LHRH antibody binding (r = -0.44). In summary, the LHRH fusion proteins were as effective as surgical spaying in suppression of estrous cycle activity, but alternating the two proteins in an immunization schedule did not enhance the immunological or biological effectiveness of the vaccine. PMID:15583055

  7. 5-ASA Affects Cell Cycle Progression in Colorectal Cells by Reversibly Activating a Replication Checkpoint

    PubMed Central

    LUCIANI, M. GLORIA; CAMPREGHER, CHRISTOPH; FORTUNE, JOHN M.; KUNKEL, THOMAS A.; GASCHE, CHRISTOPH

    2007-01-01

    Background & Aims Individuals with inflammatory bowel disease are at risk of developing colorectal cancer (CRC). Epidemiologic, animal, and laboratory studies suggest that 5-amino-salicylic acid (5-ASA) protects from the development of CRC by altering cell cycle progression and by inducing apoptosis. Our previous results indicate that 5-ASA improves replication fidelity in colorectal cells, an effect that is active in reducing mutations. In this study, we hypothesized that 5-ASA restrains cell cycle progression by activating checkpoint pathways in colorectal cell lines, which would prevent tumor development and improve genomic stability. Methods CRC cells with different genetic backgrounds such as HT29, HCT116, HCT116p53−/−, HCT116+chr3, and LoVo were treated with 5-ASA for 2–96 hours. Cell cycle progression, phosphorylation, and DNA binding of cell cycle checkpoint proteins were analyzed. Results We found that 5-ASA at concentrations between 10 and 40 mmol/L affects cell cycle progression by inducing cells to accumulate in the S phase. This effect was independent of the hMLH1, hMSH2, and p53 status because it was observed to a similar extent in all cell lines under investigation. Moreover, wash-out experiments demonstrated reversibility within 48 hours. Although p53 did not have a causative role, p53 Ser15 was strongly phosphorylated. Proteins involved in the ATM-and-Rad3-related kinase (ATR)-dependent S-phase checkpoint response (Chk1 and Rad17) were also phosphorylated but not ataxia telengectasia mutated kinase. Conclusions Our data demonstrate that 5-ASA causes cells to reversibly accumulate in S phase and activate an ATR-dependent checkpoint. The activation of replication checkpoint may slow down DNA replication and improve DNA replication fidelity, which increases the maintenance of genomic stability and counteracts carcinogenesis. PMID:17241873

  8. Effects of Space Weather on Biomedical Parameters during the Solar Activity Cycles 23-24.

    PubMed

    Ragul'skaya, M V; Rudenchik, E A; Chibisov, S M; Gromozova, E N

    2015-06-01

    The results of long-term (1998-2012) biomedical monitoring of the biotropic effects of space weather are discussed. A drastic change in statistical distribution parameters in the middle of 2005 was revealed that did not conform to usual sinusoidal distribution of the biomedical data reflecting changes in the number of solar spots over a solar activity cycle. The dynamics of space weather of 2001-2012 is analyzed. The authors hypothesize that the actual change in statistical distributions corresponds to the adaptation reaction of the biosphere to nonstandard geophysical characteristics of the 24th solar activity cycle and the probable long-term decrease in solar activity up to 2067. PMID:26085362

  9. Extremely low geomagnetic activity during the recent deep solar cycle minimum

    NASA Astrophysics Data System (ADS)

    Echer, E.; Tsurutani, B. T.; Gonzalez, W. D.

    2012-07-01

    The recent solar minimum (2008-2009) was extreme in several aspects: the sunspot number, R z , interplanetary magnetic field (IMF) magnitude B o and solar wind speed V sw were the lowest during the space era. Furthermore, the variance of the IMF southward B z component was low. As a consequence of these exceedingly low solar wind parameters, there was a minimum in the energy transfer from solar wind to the magnetosphere, and the geomagnetic activity ap index reached extremely low levels. The minimum in geomagnetic activity was delayed in relation to sunspot cycle minimum. We compare the solar wind and geomagnetic activity observed in this recent minimum with previous solar cycle values during the space era (1964-2010). Moreover, the geomagnetic activity conditions during the current minimum are compared with long term variability during the period of available geomagnetic observations. The extremely low geomagnetic activity observed in this solar minimum was previously recorded only at the end of XIX century and at the beginning of the XX century, and this might be related to the Gleissberg (80-100 years) solar cycle.

  10. PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.

    PubMed

    Gonnella, Roberta; Granato, Marisa; Farina, Antonella; Santarelli, Roberta; Faggioni, Alberto; Cirone, Mara

    2015-07-01

    PKC activation by combining TPA with sodium butyrate (T/B) represents the most effective and widely used strategy to induce the Epstein-Barr virus (EBV) lytic cycle. The results obtained in this study show that novel PKCθ is involved in such process and that it acts through the activation of p38 MAPK and autophagy induction. Autophagy, a mechanism of cellular defense in stressful conditions, is manipulated by EBV to enhance viral replication. Besides promoting the EBV lytic cycle, the activation of p38 and autophagy resulted in a pro-survival effect, as indicated by p38 or ATG5 knocking down experiments. However, this pro-survival role was counteracted by a pro-death activity of PKCθ, due to the dephosphorylation of AKT. In conclusion, this study reports, for the first time, that T/B activates a PKCθ-p38 MAPK axis in EBV infected B cells, that promotes the viral lytic cycle and cell survival and dephosphorylates AKT, balancing cell life and cell death. PMID:25827954

  11. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

    PubMed

    Sidor, M M; Spencer, S M; Dzirasa, K; Parekh, P K; Tye, K M; Warden, M R; Arey, R N; Enwright, J F; Jacobsen, J P R; Kumar, S; Remillard, E M; Caron, M G; Deisseroth, K; McClung, C A

    2015-11-01

    Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here, we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a period of euthymia at night. Mood-cycling coincides with abnormal daytime spikes in ventral tegmental area (VTA) dopaminergic activity, tyrosine hydroxylase (TH) levels and dopamine synthesis. To determine the significance of daytime increases in VTA dopamine activity to manic behaviors, we developed a novel optogenetic stimulation paradigm that produces a sustained increase in dopamine neuronal activity and find that this induces a manic-like behavioral state. Time-dependent dampening of TH activity during the day reverses manic-related behaviors in ClockΔ19 mice. Finally, we show that CLOCK acts as a negative regulator of TH transcription, revealing a novel molecular mechanism underlying cyclic changes in mood-related behavior. Taken together, these studies have identified a mechanistic connection between circadian gene disruption and the precipitation of manic episodes in bipolar disorder. PMID:25560763

  12. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

    PubMed Central

    Sidor, Michelle M.; Spencer, Sade M.; Dzirasa, Kafui; Parekh, Puja K.; Tye, Kay M.; Warden, Melissa R.; Arey, Rachel N.; Enwright, John F; Jacobsen, Jacob PR; Kumar, Sunil; Remillard, Erin M; Caron, Marc G.; Deisseroth, Karl; McClung, Colleen A

    2014-01-01

    Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a period of euthymia at night. Mood cycling coincides with abnormal daytime spikes in ventral tegmental area (VTA) dopaminergic activity, tyrosine hydroxylase (TH) levels, and dopamine synthesis. To determine the significance of daytime increases in VTA dopamine activity to manic behaviors, we developed a novel optogenetic stimulation paradigm that produces a sustained increase in dopamine neuronal activity and find that this induces a manic-like behavioral state. Time-dependent dampening of TH activity during the day reverses manic-related behaviours in ClockΔ19 mice. Finally, we show that CLOCK acts as a negative regulator of TH transcription, revealing a novel molecular mechanism underlying cyclic changes in mood-related behaviour. Taken together, these studies have identified a mechanistic connection between circadian gene disruption and the precipitation of manic episodes in bipolar disorder. PMID:25560763

  13. Recurrent Echinococcal Infection of the Lumbar Spine: An 11 Year Follow-up.

    PubMed

    Gouse, Mohamad; Amritanand, Rohit; Venkatesh, Krishnan; Sundararaj, Gabriel David

    2013-03-01

    Spinal hydatid cyst is a rare occurrence in non endemic countries. We present a case of recurrent lumbar hydatid disease in a 21-year-old male who following initial treatment had a good functional outcome and healing for 8 years, following which he came back with complaints of low back ache and neurological deficit. Patient underwent a second surgery with global debridement of L3-L5 vertebrae followed by medical management for two years. He had a good surgical outcome with recovery from the neurological deficit. Patient has returned to his routine activities and is being reviewed every year; there is no evidence of recurrence in the past 3 years. To the best of our knowledge recurrence after 8 years of initial treatment, followed by good clinical and radiological outcome for 3 years after surgery and treatment of the recurrence has not been reported in literature. PMID:23508512

  14. Individual, family, and neighborhood correlates of independent mobility among 7 to 11-year-olds.

    PubMed

    Janssen, Ian; Ferrao, Thomas; King, Nathan

    2016-06-01

    Objective. Independent mobility refers to the freedom that children have to move around their neighborhood without adult supervision. It is related to their physical activity and health. We examined the intrapersonal, family, and neighborhood correlates of independent mobility within children. Methods. 497 American parents of 6.9-11.9 year olds completed a survey (November, 2014) that assessed their child's independent mobility range, several intrapersonal characteristics of their child (gender, age, race, etc.), several characteristics of their family (family structure, socioeconomic status, parental physical activity, etc.), and their perceptions of the safety of their neighborhood (18 questions reduced to 4 components). Associations were determined using ordinal logistic regression. Results. Children's age, parent's perception that their neighborhood is safe for children, and parent's fear of neighborhood crime were the independent correlates of independent mobility. Compared to 6.9-7.9 year olds, the odds ratio (95% CI) for increasing independent mobility were 2.31 (1.47-3.64) in 8.0-9.9 year olds and 3.38 (2.13-5.36) in 10.0-11.9 year olds. Compared to children whose parents who did not perceive that their neighborhood was safe for children, the odds ratio for increasing independent mobility was 4.24 (2.68-6.70) for children whose parents perceived their neighborhood was safe for children. Compared to children whose parents had the lowest fear of neighborhood crime, the odds ratio for increasing independent mobility was 0.41 (0.27-0.62) for children whose parents had the highest fear of crime. Conclusions. Children's independent mobility was associated with their age, their parent's perception that their neighborhood was safe for children, and their parent's fear of crime. PMID:26844195

  15. Individual, family, and neighborhood correlates of independent mobility among 7 to 11-year-olds

    PubMed Central

    Janssen, Ian; Ferrao, Thomas; King, Nathan

    2015-01-01

    Objective. Independent mobility refers to the freedom that children have to move around their neighborhood without adult supervision. It is related to their physical activity and health. We examined the intrapersonal, family, and neighborhood correlates of independent mobility within children. Methods. 497 American parents of 6.9–11.9 year olds completed a survey (November, 2014) that assessed their child's independent mobility range, several intrapersonal characteristics of their child (gender, age, race, etc.), several characteristics of their family (family structure, socioeconomic status, parental physical activity, etc.), and their perceptions of the safety of their neighborhood (18 questions reduced to 4 components). Associations were determined using ordinal logistic regression. Results. Children's age, parent's perception that their neighborhood is safe for children, and parent's fear of neighborhood crime were the independent correlates of independent mobility. Compared to 6.9–7.9 year olds, the odds ratio (95% CI) for increasing independent mobility were 2.31 (1.47–3.64) in 8.0–9.9 year olds and 3.38 (2.13–5.36) in 10.0–11.9 year olds. Compared to children whose parents who did not perceive that their neighborhood was safe for children, the odds ratio for increasing independent mobility was 4.24 (2.68–6.70) for children whose parents perceived their neighborhood was safe for children. Compared to children whose parents had the lowest fear of neighborhood crime, the odds ratio for increasing independent mobility was 0.41 (0.27–0.62) for children whose parents had the highest fear of crime. Conclusions. Children's independent mobility was associated with their age, their parent's perception that their neighborhood was safe for children, and their parent's fear of crime. PMID:26844195

  16. Composite Mg II solar activity index for solar cycles 21 and 22

    NASA Technical Reports Server (NTRS)

    Deland, Matthew T.; Cebula, Richard P.

    1993-01-01

    On the basis of version 1.0 of the composite MG II solar activity index data set, it is shown that the change in the 27-day running average of the Mg II index from solar maximum to solar minimum is about 8 percent for solar cycle 21 and about 9 percent for solar cycle 22 through January 1992. Scaling factors based on the short-term variations in the Mg II index and solar irradiance data sets are developed for each instrument to estimate solar variability at mid-UV and near-UV wavelengths. A set of composite scale factors are derived for use with the present composite MG index. Near 205 cm, where solar irradiance variations are important for stratospheric chemistry, the estimated change in irradiance during solar cycle 22 is about 10 +/- 1 percent using the composite Mg II index (version 1.0) and scale factors.

  17. Magnetic activity of red secondaries: clues from the outburst cycle variations of dwarf novae

    NASA Astrophysics Data System (ADS)

    Chinarova, L. L.

    Photometric variations of 6 dwarf novae stars are studied based on the photographic observations from the Odessa, Moscow and Sonneberg plate collections and published visual monitoring data from the AFOEV database (Schweitzer E.: 1993, Bull. AFOEV, 64, 14). The moments of maxima are determined by using the "running parabola" fit (Andronov I.L., 1990, Kinematika Fizika Nebesn. Tel., v.6,,N 6, 87) with automatically determined filter half-width (Andronov I.L., 1997, As.Ap. Suppl., in press). All investigated stars exhibit significant changes not only from cycle-to-cycle, but from season-to-season as well. Secondary decade-scale cycles of smooth variations (Bianchini A., 1990, AJ 99, 1941) and abrupt switchings (Andronov I.L., Shakun L.I., 1990, ASS 169, 237) were interpreted by a solar-type activity of the red dwarf secondary in a binary system and may argue for existence of two different subgroups of the dwarf novae.

  18. Surface flux transport simulations. Inflows towards active regions and the modulation of the solar cycle.

    NASA Astrophysics Data System (ADS)

    Martin-Belda, David; Cameron, Robert

    2016-07-01

    Aims. We investigate the way near-surface converging flows towards active regions affect the build-up of magnetic field at the Sun's polar caps. In the Babcock-Leighton dynamo framework, this modulation of the polar fields could explain the variability of the solar cycle. Methods. We develop a surface flux transport code incorporating a parametrized model of the inflows and run simulations spanning several cycles. We carry out a parameter study to test how the strength and extension of the inflows affect the amplitude of the polar fields. Results. Inflows are seen to play an important role in the build-up of the polar fields, and can act as the non-linearity feedback mechanism required to limit the strength of the solar cycles in the Babcock-Leighton dynamo framework.

  19. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin

    PubMed Central

    Solarewicz, Julia Z.; Angoa-Perez, Mariana; Kuhn, Donald M.; Mateika, Jason H.

    2016-01-01

    We examined the role that serotonin has in the modulation of sleep and wakefulness across a 12-h:12-h light-dark cycle and determined whether temperature and motor activity are directly responsible for potential disruptions to arousal state. Telemetry transmitters were implanted in 24 wild-type mice (Tph2+/+) and 24 mice with a null mutation for tryptophan hydroxylase 2 (Tph2−/−). After surgery, electroencephalography, core body temperature, and motor activity were recorded for 24 h. Temperature for a given arousal state (quiet and active wake, non-rapid eye movement, and paradoxical sleep) was similar in the Tph2+/+ and Tph2−/− mice across the light-dark cycle. The percentage of time spent in active wakefulness, along with motor activity, was decreased in the Tph2+/+ compared with the Tph2−/− mice at the start and end of the dark cycle. This difference persisted into the light cycle. In contrast, the time spent in a given arousal state was similar at the remaining time points. Despite this similarity, periods of non-rapid-eye-movement sleep and wakefulness were less consolidated in the Tph2+/+ compared with the Tph2−/− mice throughout the light-dark cycle. We conclude that the depletion of serotonin does not disrupt the diurnal variation in the sleep-wake cycle, motor activity, and temperature. However, serotonin may suppress photic and nonphotic inputs that manifest at light-dark transitions and serve to shorten the ultraradian duration of wakefulness and non-rapid-eye-movement sleep. Finally, alterations in the sleep-wake cycle following depletion of serotonin are unrelated to disruptions in the modulation of temperature. PMID:25394829

  20. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

    PubMed

    Solarewicz, Julia Z; Angoa-Perez, Mariana; Kuhn, Donald M; Mateika, Jason H

    2015-01-01

    We examined the role that serotonin has in the modulation of sleep and wakefulness across a 12-h:12-h light-dark cycle and determined whether temperature and motor activity are directly responsible for potential disruptions to arousal state. Telemetry transmitters were implanted in 24 wild-type mice (Tph2(+/+)) and 24 mice with a null mutation for tryptophan hydroxylase 2 (Tph2(-/-)). After surgery, electroencephalography, core body temperature, and motor activity were recorded for 24 h. Temperature for a given arousal state (quiet and active wake, non-rapid eye movement, and paradoxical sleep) was similar in the Tph2(+/+) and Tph2(-/-) mice across the light-dark cycle. The percentage of time spent in active wakefulness, along with motor activity, was decreased in the Tph2(+/+) compared with the Tph2(-/-) mice at the start and end of the dark cycle. This difference persisted into the light cycle. In contrast, the time spent in a given arousal state was similar at the remaining time points. Despite this similarity, periods of non-rapid-eye-movement sleep and wakefulness were less consolidated in the Tph2(+/+) compared with the Tph2(-/-) mice throughout the light-dark cycle. We conclude that the depletion of serotonin does not disrupt the diurnal variation in the sleep-wake cycle, motor activity, and temperature. However, serotonin may suppress photic and nonphotic inputs that manifest at light-dark transitions and serve to shorten the ultraradian duration of wakefulness and non-rapid-eye-movement sleep. Finally, alterations in the sleep-wake cycle following depletion of serotonin are unrelated to disruptions in the modulation of temperature. PMID:25394829

  1. Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.

    PubMed

    Aix, Esther; Gutiérrez-Gutiérrez, Óscar; Sánchez-Ferrer, Carlota; Aguado, Tania; Flores, Ignacio

    2016-06-01

    The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest. We show that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21. We further show that premature telomere dysfunction pushes cardiomyocytes out of the cell cycle. Cardiomyocytes from telomerase-deficient mice with dysfunctional telomeres (G3 Terc(-/-)) show precocious development of anaphase-bridge formation, p21 up-regulation, and binucleation. In line with these findings, the cardiomyocyte proliferative response after cardiac injury was lost in G3 Terc(-/-) newborns but rescued in G3 Terc(-/-)/p21(-/-) mice. These results reveal telomere dysfunction as a crucial signal for cardiomyocyte cell-cycle arrest after birth and suggest interventions to augment the regeneration capacity of mammalian hearts. PMID:27241915

  2. Necessary Conditions for Tropical Cyclone Rapid Intensification as Derived from 11 Years of TRMM Data

    NASA Astrophysics Data System (ADS)

    Jiang, H.; Ramirez, E. M.

    2012-12-01

    Understanding and predicting intensity changes, especially rapid intensification (RI), of tropical cyclones (TCs) require some understanding of not only the large-scale environment condition, but also the convective and precipitation properties of the storm. Convective and rainfall properties of TCs are statistically quantified for different TC intensity change categories by using Tropical Rainfall Measuring Mission (TRMM) data from December 1997 to December 2008. Four 24-h future intensity change categories are defined: rapidly intensifying (RI), slowly intensifying, neutral, and weakening. Maximum convective intensity in the inner core is not necessarily more intense prior to undergoing an RI episode than a slowly intensifying, neutral, or weakening episode. Instead, a minimum threshold of convective intensity, raining area, and total volumetric rain in the inner core has to be reached before a storm undergoes RI. The following necessary conditions for RI are found in the inner core: maximum near surface radar reflectivity > 40 dBZ, maximum 20 (30, 40) dBZ echo height > 8 (6, 4) km, minimum 85 (37) GHz polarization corrected brightness temperature (PCT) < 235 (275) K, minimum 10.8 μm brightness temperature < 220 K, total raining area > 3,000 km^2, and total volumetric rain > 5,000 mm h-1 km^2. It is also found that total lightning activities in the inner core (outer rainband) have a negative (positive) relationship with storm intensification.

  3. Effectiveness and Student Perceptions of an Active Learning Activity Using a Headline News Story to Enhance In-Class Learning of Cell Cycle Regulation

    ERIC Educational Resources Information Center

    Dirks-Naylor, Amie J.

    2016-01-01

    An active learning activity was used to engage students and enhance in-class learning of cell cycle regulation in a PharmD level integrated biological sciences course. The aim of the present study was to determine the effectiveness and perception of the in-class activity. After completion of a lecture on the topic of cell cycle regulation,…

  4. 1997-2008: 11 years of European-Mediterranean Regional Centroid Moment Tensors and their dissemination

    NASA Astrophysics Data System (ADS)

    Pondrelli, S.; Morelli, A.; Ekström, G.; Postpischl, L.; Salimbeni, S.

    2008-12-01

    The European-Mediterranean Regional Centroid Moment Tensor (RCMT) Catalog collects seismic moment tensor solutions that have been routinely computed since 1997 for earthquakes with moderate magnitude (4.5 < M < 5.5) in the Mediterranean region. This database represents an extension to smaller magnitudes of the Global CMT catalog (http://www.globalcmt.org). RCMT computation is based on the analysis of seismograms recorded at regional distances, and modeling of intermediate period surface waves. The Catalog is regularly updated a few months behind real time, and reports are published in Phys. Earth Planet. Int. and on the worldwide web (http://www.bo.ingv.it/RCMT). However, moment tensors can also be computed on the basis of data available in quasi-real time. Such preliminary solutions are available within one or a few hours after an earthquake occurs, and published as a Quick RCMTs. The European- Mediterranean RCMT Catalog currently includes more than 850 seismic moment tensor solutions, mainly located in the most seismically active areas, such as northern Greece and the Hellenic trench. In the consideration of the size of the Catalog, we developed a web-search interface that allows to query the SQL database on geographical, time and magnitudes (mb, Ms and Mw) ranges. The results can then be formatted and exported in various formats, or mapped directly on the web page (beach balls). Two important flags were introduced, allowing us to include in the database new events still in the preliminary stages of analysis or in need of further refinements. The first flag distinguishes Definitive and Quick solutions, while the second one categorizes events in 4 Quality levels on the basis of changes of centroid coordinates or when the depth needs to be fixed or when the double couple component is too big (Pondrelli et al., PEPI, 2006).

  5. Polarity Reversal of the Solar Photospheric Magnetic Field During Activity Cycle 24

    NASA Astrophysics Data System (ADS)

    Sun, Xudong; Hoeksema, Jon Todd; Liu, Yang; Zhao, Junwei

    2014-06-01

    The large-scale solar magnetic field reverses its polarity during the maximum phase of each activity cycle. As observed on the photosphere, active region (AR) magnetic flux migrates poleward in narrow, sheared streams resulted from large-scale flows and diffusion. A small net flux of the trailing sunspot polarity eventually aggregates at high latitudes, manifesting the poloidal field of the next cycle. We characterize this process for the ongoing cycle 24 based on four years' line-of-sight magnetograms from the Helioseismic and Magnetic Imager (HMI). The axial dipole component reversed sign in early 2012, but the poleward flux migration was grossly out of phase in the two hemispheres. As a proxy, the northern polar field (taken as mean above 70 degrees latitude) switched from negative to positive in late 2012, whereas the southern remained positive as of March 2014. Three factors that are in line with the surface flux transport model may have contributed. First, AR emergence started and peaked earlier in the north. Second, several ARs with small or inverse tilt angles (w.r.t. the Joy's law) emerged in the south in late 2010. Third, meridional flow speed inferred from helioseismology varied greatly prior to 2013; slower streams (compared to a three-year mean at the same latitude) appeared earlier in the north. We correlate HMI with the long-running Wilcox Solar Observatory (WSO) dataset, and compare the current cycle with the previous three.

  6. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.

    SciTech Connect

    Morrish, Fionnuala M.; Isern, Nancy; Sadilek, Martin; Jeffrey, Mark; Hockenbery, David M.

    2009-05-18

    Cell proliferation requires the coordinated activity of cytosolic and mitochondrial metabolic pathways to provide ATP and building blocks for DNA, RNA, and protein synthesis. Many metabolic pathway genes are targets of the c-myc oncogene and cell cycle regulator. However, the contribution of c-Myc to the activation of cytosolic and mitochondrial metabolic networks during cell cycle entry is unknown. Here, we report the metabolic fates of [U-13C] glucose in serum-stimulated myc-/- and myc+/+ fibroblasts by 13C isotopomer NMR analysis. We demonstrate that endogenous c-myc increased 13C-labeling of ribose sugars, purines, and amino acids, indicating partitioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic acid cycle turnover at the expense of anaplerotic flux. Myc expression also increased global O-linked GlcNAc protein modification, and inhibition of hexosamine biosynthesis selectively reduced growth of Myc-expressing cells, suggesting its importance in Myc-induced proliferation. These data reveal a central organizing role for the Myc oncogene in the metabolism of cycling cells. The pervasive deregulation of this oncogene in human cancers may be explained by its role in directing metabolic networks required for cell proliferation.

  7. Effect of seat positions on discomfort, muscle activation, pressure distribution and pedal force during cycling.

    PubMed

    Verma, Rachita; Hansen, Ernst A; de Zee, Mark; Madeleine, Pascal

    2016-04-01

    The aim of this study was to measure and analyse discomfort and biomechanics of cycling, i.e., muscle activation, centre of pressure of seat pressure profiles and pedal forces as a function of seat position. Twenty-one recreationally active individuals cycled for 10min at 100W on an ergometer cycle using five different seat positions. The neutral position was considered as basic seat position and was compared with upward, downward, forward and backward seat positions. The initial bout was repeated at the end of the recording session. Discomfort increased for upward and backward condition compared with neutral (P<0.05). Normalized surface electromyography from gastrocnemius decreased in the downward and forward position but increased in the upward and backward position. The minimum force became less negative for forward position compared with neutral seat position (P<0.05). The degree of variability of centre of pressure increased in the upward and backward position and the entropy of the centre of pressure of sitting posture for backward position decreased compared with neutral seat position (P<0.05). The present study revealed that consecutive changes of seat position over time lead to increase in discomfort as well as alterations of the biomechanics of cycling. PMID:26938676

  8. Regulation of the yeast metabolic cycle by transcription factors with periodic activities

    PubMed Central

    2011-01-01

    Background When growing budding yeast under continuous, nutrient-limited conditions, over half of yeast genes exhibit periodic expression patterns. Periodicity can also be observed in respiration, in the timing of cell division, as well as in various metabolite levels. Knowing the transcription factors involved in the yeast metabolic cycle is helpful for determining the cascade of regulatory events that cause these patterns. Results Transcription factor activities were estimated by linear regression using time series and genome-wide transcription factor binding data. Time-translation matrices were estimated using least squares and were used to model the interactions between the most significant transcription factors. The top transcription factors have functions involving respiration, cell cycle events, amino acid metabolism and glycolysis. Key regulators of transitions between phases of the yeast metabolic cycle appear to be Hap1, Hap4, Gcn4, Msn4, Swi6 and Adr1. Conclusions Analysis of the phases at which transcription factor activities peak supports previous findings suggesting that the various cellular functions occur during specific phases of the yeast metabolic cycle. PMID:21992532

  9. RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints.

    PubMed

    Mamidipudi, V; Dhillon, N K; Parman, T; Miller, L D; Lee, K C; Cartwright, C A

    2007-05-01

    Previously, we showed that Src tyrosine kinases are activated early in the development of human colon cancer and are suppressed as intestinal cells differentiate. We identified RACK1 as an endogenous substrate, binding partner and inhibitor of Src. Here we show (by overexpressing RACK1, depleting Src or RACK1 and utilizing cell-permeable peptides that perturb RACK1's interaction with Src) that RACK1 regulates growth of colon cells by suppressing Src activity at G(1) and mitotic checkpoints, and consequently delaying cell cycle progression. Activated Src rescues RACK1-inhibited growth of HT-29 cells. Conversely, inhibiting Src abolishes growth promoted by RACK1 depletion in normal cells. Two potential mechanisms whereby RACK1 regulates mitotic exit are identified: suppression of Src-mediated Sam68 phosphorylation and maintenance of the cyclin-dependent kinase (CDK) 1-cyclin B complex in an active state. Our results reveal novel mechanisms of cell cycle control in G(1) and mitosis of colon cells. The significance of this work lies in the discovery of a mechanism by which the growth of colon cancer cells can be slowed, by RACK1 suppression of an oncogenic kinase at critical cell cycle checkpoints. Small molecules that mimic RACK1 function may provide a powerful new approach to the treatment of colon cancer. PMID:17072338

  10. Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

    PubMed Central

    Schraufstätter, I U; Hinshaw, D B; Hyslop, P A; Spragg, R G; Cochrane, C G

    1985-01-01

    Exposure of target cells to a bolus of H2O2 induced cell lysis after a latent period of several hours, which was prevented only when the H2O2 was removed within the first 30 min of injury by addition of catalase. This indicated that early metabolic events take place that are important in the fate of the cell exposed to oxidants. In this study, we described two early and independent events of H2O2-induced injury in P388D1 macrophagelike tumor cells: activation of the glutathione cycle and depletion of cellular NAD. Glutathione cycle and hexose monophosphate shunt (HMPS) were activated within seconds after the addition of H2O2. High HMPS activity maintained glutathione that was largely reduced. However, when HMPS activity was inhibited--by glucose depletion or by incubation at 4 degrees C--glutathione remained in the oxidized state. Total pyridine nucleotide levels were diminished when cells were exposed to H2O2, and the breakdown product, nicotinamide, was recovered in the extracellular medium. Intracellular NAD levels fell by 80% within 20 min of exposure of cells to H2O2. The loss of NADP(H) and stimulation of the HMPS could be prevented when the glutathione cycle was inhibited by either blocking glutathione synthesis with buthionine sulfoximine (BSO) or by inhibiting glutathione reductase with (1,3-bis) 2 chlorethyl-1-nitrosourea. The loss of NAD developed independently of glutathione cycle and HMPS activity, as it also occurred in BSO-treated cells. PMID:3840176

  11. A role for the habenula in the regulation of locomotor activity cycles

    PubMed Central

    Paul, Matthew J.; Indic, Premananda; Schwartz, William J.

    2015-01-01

    While much is known about the regulation of the circadian rest-activity cycle by the hypothalamic suprachiasmatic nucleus in nocturnal rodents, little is known about the neural substrates that regulate the temporal organization of nocturnal activity within the active phase. In this paper, data are presented in Syrian hamsters to implicate the habenula – believed to be involved in motivation, reward, and motor control – as a candidate site for such a role. First, by examining hamsters during the day and night and by introducing a “novel” running wheel in order to induce daytime motor activity, we show that immunoreactive c-Fos expression in the lateral and medial habenula is related to motor activity / arousal. Second, by transecting the habenula’s major efferent pathway (fasciculus retroflexus), we show that the interruption of habenula neural output alters the daily amount of motor activity; lengthens the period of the circadian rest-activity rhythm; and disrupts the species-typical pattern of nocturnal motor activity, measured as either wheel running behavior or general locomotor activity. Instead of the usual pattern of nighttime locomotion, characterized by a prolonged bout of elevated activity in the early night followed by shorter sporadic bouts or the cessation of activity altogether, lesioned animals exhibited a more homogeneous, undifferentiated temporal profile extending across the night. These data suggest a previously unrecognized function of the habenula whereby it regulates the temporal pattern of activity occurring within a circadian rest-activity window set by the suprachiasmatic nucleus. PMID:21777302

  12. Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification

    PubMed Central

    Prosser, Suzanna L.; Samant, Mugdha D.; Baxter, Joanne E.; Morrison, Ciaran G.; Fry, Andrew M.

    2014-01-01

    Centrosome duplication is licensed by the disengagement, or ‘uncoupling’, of centrioles during late mitosis. However, arrest of cells in G2 can trigger premature centriole disengagement. Here, we show that premature disengagement results from untimely activation of the APC/C leading to securin degradation and release of active separase. APC/C activation during G2 arrest is dependent on Plk1-mediated degradation of the APC/C inhibitor, Emi1, but Plk1 also has a second APC/C-independent role in promoting disengagement. Importantly, APC/C and Plk1 activity also stimulate centriole disengagement in response to hydroxyurea or DNA damage-induced cell cycle arrest and this leads to centrosome amplification. However, the re-duplication of disengaged centrioles is dependent on Cdk2 activity and Cdk2 activation coincides with a subsequent inactivation of the APC/C and re-accumulation of cyclin A. Release from these arrests leads to mitotic entry but, due to the presence of disengaged and/or amplified centrosomes, formation of abnormal mitotic spindles that lead to chromosome missegregation. Thus, oscillation of APC/C activity during cell cycle arrest promotes both centrosome amplification and genome instability. PMID:22956538

  13. Developmental pathways of language and social communication problems in 9-11 year olds: unpicking the heterogeneity.

    PubMed

    Roy, P; Chiat, S

    2014-10-01

    This paper addressed relations between language, social communication and behaviour, and their trajectories, in a sample of 9-11-year-olds (n=91) who had been referred to clinical services with concerns about language as pre-schoolers. Children were first assessed at 2½-4 years, and again 18 months later. Results revealed increasing differentiation of profiles across time. By 9-11 years, 11% of the sample had social communication deficits, 27% language impairment, 20% both, and 42% neither. The size of group differences on key language and social communication measures was striking (2-3 standard deviations). Social communication deficits included autistic mannerisms and were associated with social, emotional and behavioural difficulties (SEBDs); in contrast, language impairment was associated with hyperactivity only. Children with both language and social communication problems had the most severe difficulties on all measures. These distinct school-age profiles emerged gradually. Investigation of developmental trajectories revealed that the three impaired groups did not differ significantly on language or SEBD measures when the children were first seen. Only low performance on the Early Sociocognitive Battery, a new measure of social responsiveness, joint attention and symbolic understanding, differentiated the children with and without social communication problems at 9-11 years. These findings suggest that some children who first present with language delay or difficulties have undetected Autism Spectrum Disorders which may or may not be accompanied by language impairment in the longer term. This new evidence of developmental trajectories starting in the preschool years throws further light on the nature of social communication and language problems in school-age children, relations between language impairment and SEBDs, and on the nature of early language development. PMID:25005063

  14. The between-day reproducibility of fasting, satiety-related analytes, in 8 to 11year-old boys.

    PubMed

    Allsop, Susan; Rumbold, Penny L S; Green, Benjamin P

    2016-10-01

    The aim of the present study was to establish the between-day reproducibility of fasting plasma GLP-17-36, glucagon, leptin, insulin and glucose, in lean and overweight/obese 8-11year-old boys. A within-group study design was utilised wherein the boys attended two study days, separated by 1week, where a fasting fingertip capillary blood sample was obtained. Deming regression, mean difference, Bland-Altman limits of agreement (LOA) and typical imprecision as a percentage coefficient of variation (CV %), were utilised to assess reproducibility between-days. On a group level, Deming regression detected no evidence of systematic or proportional bias between-days for all of the satiety-related analytes however, only glucose and plasma GLP-17-36 displayed low typical and random imprecision. When analysed according to body composition, good reproducibility was maintained for glucose in the overweight/obese boys and for plasma GLP-17-36, in those with lean body mass. The present findings demonstrate that the measurement of glucose and plasma GLP-17-36 by fingertip capillary sampling on a group level, is reproducible between-days, in 8-11year-old boys. Comparison of blood glucose obtained by fingertip capillary sampling can be made between lean and overweight/obese 8-11year-old boys. Presently, the comparison of fasting plasma GLP-17-36 according to body weight is inappropriate due to high imprecision observed in lean boys between-days. The use of fingertip capillary sampling in the measurement of satiety-related analytes has the potential to provide a better understanding of mechanisms that affect appetite and feeding behaviour in children. PMID:27265877

  15. Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome.

    PubMed

    Mazerkina, Nadia; Trunin, Yuri; Gorelyshev, Sergey; Golanov, Andrey; Kadashev, Boris; Shishkina, Liudmila; Rotin, Daniil; Karmanov, Maxim; Orlova, Elizabet

    2016-02-01

    Thyrotropinomas (TSHomas) are rare pituitary adenomas, particularly in childhood. We present here the case of an 11-year-old boy with type 1 autoimmune polyglandular syndrome (APS1) and TSHoma which was diagnosed by elevated thyroid - stimulating hormone and thyroid hormones levels without evident clinical signs of hyperthyroidism. He was underwent partial resection of the tumor via transsphenoidal approach and subsequently radiation therapy. Consequently, 1 year after radiotherapy, the patient developed growth hormone deficiency, three and half years after radiation became euthyroid, and five and half years after treatment - hypothyroid. This is the first case of the coexistence of these two rare endocrine diseases in one patient. PMID:26244671

  16. The influence of sexual cycle on the MFO activity: A practical problem in biomonitoring

    SciTech Connect

    Fossi, C.; Leonzio, C.; Focardi, S. )

    1988-09-01

    During the last several years the induction of the mixed function oxidases system has been commonly used as a biochemical markers of xenobiotics contamination in aquatic, marine and terrestrial animals. The use of this index of stress in wild animals like birds has directly contributed to their ability to detect and understand the significance of the exposure to liphosoluble contaminants in the environment. Nevertheless, several intrinsic factors, such as for example the hormonal modulation during the sexual cycle, seems to significantly modify the activity of some monooxygenases. The aim of this paper is to underline, using three different examples of studies in wild birds exposed to PCBs, the role of the sexual cycles in the modification of MFO activity and consequently the importance of considering this aspect in planning biomonitoring.

  17. Integrated gasification combined-cycle research development and demonstration activities in the US

    SciTech Connect

    Ness, H.M.; Brdar, R.D.

    1996-09-01

    The United States Department of Energy (DOE)`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D) program that supports the commercialization of integrated gasification combined-cycle (IGCC) advanced power systems. This overview briefly describes the supporting RD&D activities and the IGCC projects selected for demonstration in the Clean Coal Technology (CCT) Program.

  18. Integrated gasification combined-cycle research development and demonstration activities in the U.S.

    SciTech Connect

    Ness, H.M.

    1994-12-31

    The United States Department of Energy (DOE) has selected seven integrated gasification combined-cycle (IGCC) advanced power systems for demonstration in the Clean Coal Technology (CCT) Program. DOE`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D)program that supports the CCT program, and addresses long-term improvements in support of IGCC technology. This overview briefly describes the CCT projects and the supporting RD&D activities.

  19. Meridional flow velocities on solar-like stars with known activity cycles

    NASA Astrophysics Data System (ADS)

    Baklanova, Dilyara; Plachinda, Sergei

    2015-02-01

    The direct measurements of the meridional flow velocities on stars are impossible today. To evaluate the meridional flow velocities on solar-like stars with stable activity periods, we supposed that during the stellar Hale cycle the matter on surfaces of stars passes the meridional way equivalent to 2 πR★ . We present here the dependence of the mean meridional flow velocity on Rossby number, which is an effective parameter of the stellar magnetic dynamo.

  20. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest

    PubMed Central

    Granier, Celine J.; Wang, Wei; Tsang, Tiffany; Steward, Ruth; Sabaawy, Hatem E.; Bhaumik, Mantu; Rabson, Arnold B.

    2014-01-01

    ABSTRACT PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In order to better understand the functions of PDCD2 in mammalian development, we have examined PDCD2 activity in mouse blastocyst embryos, as well as in mouse embryonic stem cells (ESCs) and embryonic fibroblasts (MEFs). We have studied mice bearing a targeted PDCD2 locus functioning as a null allele through a splicing gene trap, or as a conditional knockout, by deletion of exon2 containing the MYND domain. Tamoxifen-induced knockout of PDCD2 in MEFs, as well as in ESCs, leads to defects in progression from the G1 to the S phase of cell cycle, associated with increased levels of p53 protein and p53 target genes. G1 prolongation in ESCs was not associated with induction of differentiation. Loss of entry into S phase of the cell cycle and marked induction of nuclear p53 were also observed in PDCD2 knockout blastocysts. These results demonstrate a unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse. PMID:25150276

  1. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest.

    PubMed

    Granier, Celine J; Wang, Wei; Tsang, Tiffany; Steward, Ruth; Sabaawy, Hatem E; Bhaumik, Mantu; Rabson, Arnold B

    2014-01-01

    PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In order to better understand the functions of PDCD2 in mammalian development, we have examined PDCD2 activity in mouse blastocyst embryos, as well as in mouse embryonic stem cells (ESCs) and embryonic fibroblasts (MEFs). We have studied mice bearing a targeted PDCD2 locus functioning as a null allele through a splicing gene trap, or as a conditional knockout, by deletion of exon2 containing the MYND domain. Tamoxifen-induced knockout of PDCD2 in MEFs, as well as in ESCs, leads to defects in progression from the G1 to the S phase of cell cycle, associated with increased levels of p53 protein and p53 target genes. G1 prolongation in ESCs was not associated with induction of differentiation. Loss of entry into S phase of the cell cycle and marked induction of nuclear p53 were also observed in PDCD2 knockout blastocysts. These results demonstrate a unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse. PMID:25150276

  2. Regulation of Brain Activity in the Fusiform Face and Parahippocampal Place Areas in 7-11-Year-Old Children

    ERIC Educational Resources Information Center

    Vuontela, Virve; Jiang, Ping; Tokariev, Maksym; Savolainen, Petri; Ma, YuanYe; Aronen, Eeva T.; Fontell, Tuija; Liiri, Tiina; Ahlstrom, Matti; Salonen, Oili; Carlson, Synnove

    2013-01-01

    Developmental studies have demonstrated that cognitive processes such as attention, suppression of interference and memory develop throughout childhood and adolescence. However, little is currently known about the development of top-down control mechanisms and their influence on cognitive performance. In the present study, we used functional…

  3. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    PubMed Central

    Liu, Pengda; Begley, Michael; Michowski, Wojciech; Inuzuka, Hiroyuki; Ginzberg, Miriam; Gao, Daming; Tsou, Peiling; Gan, Wenjian; Papa, Antonella; Kim, Byeong Mo; Wan, Lixin; Singh, Amrik; Zhai, Bo; Yuan, Min; Wang, Zhiwei; Gygi, Steven P.; Lee, Tae Ho; Lu, Kun-Ping; Toker, Alex; Pandolfi, Pier Paolo; Asara, John M.; Kirschner, Marc W.; Sicinski, Piotr; Cantley, Lewis; Wei, Wenyi

    2014-01-01

    Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and metabolism. Akt hyperactivation contributes to many pathophysiological conditions, including human cancers1–3, and is closely associated with poor prognosis and chemo- or radio-therapeutic resistance4. Phosphorylation of Akt at S473 (ref. 5) and T308 (ref. 6) activates Akt. However, it remains unclear whether further mechanisms account for full Akt activation, and whether Akt hyperactivation is linked to misregulated cell cycle progression, another cancer hallmark7. Here we report that Akt activity fluctuates across the cell cycle, mirroring cyclin A expression. Mechanistically, phosphorylation of S477 and T479 at the Akt extreme carboxy terminus by cyclin-dependent kinase 2 (Cdk2)/cyclin A or mTORC2, under distinct physiological conditions, promotes Akt activation through facilitating, or functionally compensating for, S473 phosphorylation. Furthermore, deletion of the cyclin A2 allele in the mouse olfactory bulb leads to reduced S477/T479 phosphorylation and elevated cellular apoptosis. Notably, cyclin A2-deletion-induced cellular apoptosis in mouse embryonic stem cells is partly rescued by S477D/T479E-Akt1, supporting a physiological role for cyclin A2 in governing Akt activation. Together, the results of our study show Akt S477/T479 phosphorylation to be an essential layer of the Akt activation mechanism to regulate its physiological functions, thereby providing a new mechanistic link between aberrant cell cycle progression and Akt hyperactivation in cancer. PMID:24670654

  4. Behavioral and ERP evidence of word and pseudoword superiority effects in 7- and 11-year-olds.

    PubMed

    Coch, Donna; Mitra, Priya; George, Elyse

    2012-11-27

    In groups of 7-year-olds and 11-year-olds, event-related potentials (ERPs) were recorded to briefly presented, masked letter strings that included real word (DARK/PARK), pronounceable pseudoword (DARL/PARL), unpronounceable nonword (RDKA/RPKA), and letter-in-xs (DXXX, PXXX) stimuli in a variant of the Reicher-Wheeler paradigm. Behaviorally, participants decided which of two letters occurred at a given position in each string (here, forced-choice alternatives D and P). Both groups showed evidence of behavioral word (more accurate choices for letters in words than in baseline nonwords or letter-in-xs) and pseudoword (more accurate choices for letters in pseudowords than in baseline nonwords or letter-in-xs) superiority effects. Electrophysiologically, 11-year-olds evidenced superiority effects on P150 and N400 peak amplitude, while 7-year-olds showed effects only on N400 amplitude. These findings suggest that the mechanisms underlying the observed behavioral superiority effects may be lexical in younger children but both sublexical and lexical in older children. These results are consistent with a lengthy developmental time course for automatic sublexical orthographic specialization, extending beyond the age of 11. PMID:23036274

  5. Representation and performance: reproduction of form and quality of movement in dance by eight- and 11-year-old novices.

    PubMed

    Cadopi, M; Chatillon, J F; Baldy, R

    1995-05-01

    This study examined the effects of age on the cognitive representations in modelling. A total of 48 eight- and 11-year-olds were asked to watch a dancer performing a ballet sequence of three steps in order to reproduce it. They were able to see the film as many times as they wanted. All subjects were novices to dance. Both quantitative (number of observations required to learn the sequence, number of steps executed) and qualitative (form and quality of the performance) factors were assessed. The results indicated an effect of age on the number of requested observations and on the number of subjects able to perform the entire movement series. The mean form scores did not differ significantly between the two groups, but the mean quality score was higher for the 11-year-olds. We also noted a great heterogeneity in the performances. The results are discussed in terms of the role of cognitive and motor factors in observational learning by age and of the possibilities that cognitive representations offer for coding the different properties of movement. PMID:7795942

  6. Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity

    PubMed Central

    Woodman, Julie; Fara, Tyler; Dzieciatkowska, Monika; Trejo, Michael; Luong, Nancy; Hansen, Kirk C.; Megee, Paul C.

    2014-01-01

    Sister chromatid cohesion (SCC), efficient DNA repair, and the regulation of some metazoan genes require the association of cohesins with chromosomes. Cohesins are deposited by a conserved heterodimeric loading complex composed of the Scc2 and Scc4 proteins in Saccharomyces cerevisiae, but how the Scc2/Scc4 deposition complex regulates the spatiotemporal association of cohesin with chromosomes is not understood. We examined Scc2 chromatin association during the cell division cycle and found that the affinity of Scc2 for chromatin increases biphasically during the cell cycle, increasing first transiently in late G1 phase and then again later in G2/M. Inactivation of Scc2 following DNA replication reduces cellular viability, suggesting that this post S-phase increase in Scc2 chromatin binding affinity is biologically relevant. Interestingly, high and low Scc2 chromatin binding levels correlate strongly with the presence of full-length or amino-terminally cleaved forms of Scc2, respectively, and the appearance of the cleaved Scc2 species is promoted in vitro either by treatment with specific cell cycle-staged cellular extracts or by dephosphorylation. Importantly, Scc2 cleavage eliminates Scc2–Scc4 physical interactions, and an scc2 truncation mutant that mimics in vivo Scc2 cleavage is defective for cohesin deposition. These observations suggest a previously unidentified mechanism for the spatiotemporal regulation of cohesin association with chromosomes through cell cycle regulation of Scc2 cohesin deposition activity by Scc2 dephosphorylation and cleavage. PMID:24778232

  7. Stellar activity as noise in exoplanet detection - I. Methods and application to solar-like stars and activity cycles

    NASA Astrophysics Data System (ADS)

    Korhonen, H.; Andersen, J. M.; Piskunov, N.; Hackman, T.; Juncher, D.; Järvinen, S. P.; Jørgensen, U. G.

    2015-04-01

    The detection of exoplanets using any method is prone to confusion due to the intrinsic variability of the host star. We investigate the effect of cool starspots on the detectability of the exoplanets around solar-like stars using the radial velocity method. For investigating this activity-caused `jitter' we calculate synthetic spectra using radiative transfer, known stellar atomic and molecular lines, different surface spot configurations and an added planetary signal. Here, the methods are described in detail, tested and compared to previously published studies. The methods are also applied to investigate the activity jitter in old and young solar-like stars, and over a solar-like activity cycles. We find that the mean full jitter amplitude obtained from the spot surfaces mimicking the solar activity varies during the cycle approximately between 1 and 9 m s-1. With a realistic observing frequency a Neptune-mass planet on a 1-yr orbit can be reliably recovered. On the other hand, the recovery of an Earth-mass planet on a similar orbit is not feasible with high significance. The methods developed in this study have a great potential for doing statistical studies of planet detectability, and also for investigating the effect of stellar activity on recovered planetary parameters.

  8. Evolution of sunspot activity and inversion of the Sun's polar magnetic field in the current cycle

    NASA Astrophysics Data System (ADS)

    Mordvinov, A. V.; Grigoryev, V. M.; Erofeev, D. V.

    2015-06-01

    A spatiotemporal analysis of the Sun's magnetic field was carried out to study the polar-field inversion in the current cycle in relation to sunspot activity. The causal relationship between these phenomena was demonstrated in a time-latitude aspect. After decay of long-lived activity complexes their magnetic fields were redistributed into the surrounding photosphere and formed unipolar magnetic regions which were transported to high latitudes. Zones of intense sunspot activity during 2011/2012 produced unipolar magnetic regions of the following polarities, whose poleward drift led to the inversion of the Sun's polar fields at the North and South Poles. At the North Pole the polar field reversal was completed by May 2013. It was demonstrated that mixed magnetic polarities near the North Pole resulted from violations of Joy's law at lower latitudes. Later sunspot activity in the southern hemisphere has led to a delay in magnetic polarity reversal at the South Pole. Thus, the north-south asymmetry of sunspot activity resulted in asynchronous polar field reversal in the current cycle.

  9. Evaluation of Active Working Fluids for Brayton Cycles in Space Applications

    NASA Astrophysics Data System (ADS)

    Conklin, J. C.; Courville, G. E.; Scott, J. H.

    2004-02-01

    The main parameter of interest for space thermal power conversion to electricity is specific power, defined as the total electric power output per unit of system mass, rather than the cycle thermal efficiency. For a closed Brayton cycle, performance with two active working fluids, nitrogen tetroxide and aluminum chloride, is compared to that with an inert mixture of helium and xenon having a molecular mass of 40. A chemically active working fluid is defined here as a chemical compound that has a relatively high molecular weight at temperatures appropriate for the compressor inlet and dissociates to a lighter molecular weight fluid at typical turbine inlet temperatures. The active working fluids may have the advantage of a higher net turbomachinery work output and an advantageous enhancement of the heat transfer coefficient in the heat exchangers. The fundamental theory of the active working fluid concept is presented to demonstrate these potential advantages. Scoping calculations of the heat exchanger mass for a selected spacecraft application of 36.4 kW of electrical power output show that the nitrogen tetroxide active working fluid has an advantageous 7% to 30% lower mass-to-power ratio than that for the inert noble gas mixture, depending on the allowable turbine inlet temperature. The calculations for the aluminum chloride system suggest only a slight improvement in performance relative to the inert noble gas mixture.

  10. Infection with Trypanosoma cruzi TcII and TcI in free-ranging population of lion tamarins (Leontopithecus spp): an 11-year follow-up.

    PubMed

    Lisboa, Cristiane Varella; Monteiro, Rafael Veríssimo; Martins, Andreia Fonseca; Xavier, Samantha Cristina das Chagas; Lima, Valdirene Dos Santos; Jansen, Ana Maria

    2015-05-01

    Here, we present a review of the dataset resulting from the 11-years follow-up of Trypanosoma cruzi infection in free-ranging populations of Leontopithecus rosalia (golden lion tamarin) and Leontopithecus chrysomelas (golden-headed lion tamarin) from distinct forest fragments in Atlantic Coastal Rainforest. Additionally, we present new data regarding T. cruzi infection of small mammals (rodents and marsupials) that live in the same areas as golden lion tamarins and characterisation at discrete typing unit (DTU) level of 77 of these isolates. DTU TcII was found to exclusively infect primates, while TcI infected Didelphis aurita and lion tamarins. The majority of T. cruzi isolates derived from L. rosalia were shown to be TcII (33 out 42) Nine T. cruzi isolates displayed a TcI profile. Golden-headed lion tamarins demonstrated to be excellent reservoirs of TcII, as 24 of 26 T. cruzi isolates exhibited the TcII profile. We concluded the following: (i) the transmission cycle of T. cruzi in a same host species and forest fragment is modified over time, (ii) the infectivity competence of the golden lion tamarin population fluctuates in waves that peak every other year and (iii) both golden and golden-headed lion tamarins are able to maintain long-lasting infections by TcII and TcI. PMID:25946156

  11. Infection with Trypanosoma cruzi TcII and TcI in free-ranging population of lion tamarins (Leontopithecus spp): an 11-year follow-up

    PubMed Central

    Lisboa, Cristiane Varella; Monteiro, Rafael Veríssimo; Martins, Andreia Fonseca; Xavier, Samantha Cristina das Chagas; Lima, Valdirene dos Santos; Jansen, Ana Maria

    2015-01-01

    Here, we present a review of the dataset resulting from the 11-years follow-up of Trypanosoma cruzi infection in free-ranging populations of Leontopithecus rosalia (golden lion tamarin) and Leontopithecus chrysomelas (golden-headed lion tamarin) from distinct forest fragments in Atlantic Coastal Rainforest. Additionally, we present new data regarding T. cruzi infection of small mammals (rodents and marsupials) that live in the same areas as golden lion tamarins and characterisation at discrete typing unit (DTU) level of 77 of these isolates. DTU TcII was found to exclusively infect primates, while TcI infected Didelphis aurita and lion tamarins. The majority of T. cruzi isolates derived from L. rosalia were shown to be TcII (33 out 42) Nine T. cruzi isolates displayed a TcI profile. Golden-headed lion tamarins demonstrated to be excellent reservoirs of TcII, as 24 of 26 T. cruzi isolates exhibited the TcII profile. We concluded the following: (i) the transmission cycle of T. cruzi in a same host species and forest fragment is modified over time, (ii) the infectivity competence of the golden lion tamarin population fluctuates in waves that peak every other year and (iii) both golden and golden-headed lion tamarins are able to maintain long-lasting infections by TcII and TcI. PMID:25946156

  12. Comparison of solar activity during last two minima on turn of Activity Cycles 22/23 and 23/24

    NASA Astrophysics Data System (ADS)

    Gryciuk, Magdalena; Gburek, Szymon; Siarkowski, Marek; Podgorski, Piotr; Sylwester, Janusz; Farnik, Frantisek

    2013-07-01

    The subject of our work is the review and comparison of solar activity during the last two solar minima that occurred between recent activity cycles. We use the soft X-ray global solar corona observations covering the two nine-months long time intervals in 1997/98 and 2009. Data from RF15-I multichannel photometer are used for the penultimate minimum. For the last unusually deep and prolonged solar activity minimum in 2009 the data from SphinX spectrophotometer are used. Comparison of measurements from both minima takes place in the overlapping energy range 2-15 keV. We focus on the active region formation, evolution and flaring productivity during respective minima.

  13. Functional near infrared spectroscopy study of age-related difference in cortical activation patterns during cycling with speed feedback.

    PubMed

    Lin, Pei-Yi; Lin, Sang-I; Chen, Jia-Jin J

    2012-01-01

    Functional decline of lower-limb affects the ability of locomotion and the age-related brain differences have been elucidated among the elderly. Cycling exercise is a common training program for restoring motor function in the deconditioned elderly or stroke patients. The provision of speed feedback has been commonly suggested to clinical therapists for facilitating learning of controlled cycling performance and maintaining motivation in training programs with elderly participants. However, the cortical control of pedaling movements and the effect of external feedback remain poorly understanding. This study investigated the regional cortical activities detected by functional near infrared spectroscopy (fNIRS) in 12 healthy young and 13 healthy elderly subjects under conditions of cycling without-(free cycling) and with feedback (target cycling). The elderly exhibited predominant activation of the sensorimotor cortex during free cycling similar to young subjects but with poorer cycling performance. The cycling performance improved in both groups, and the elderly showed increased brain activities of the supplementary motor area and premotor cortex under target cycling condition. These findings demonstrated age-related changes in the cortical control in processing external feedback and pedaling movements. Use of fNIRS to evaluate brain activation patterns after training may facilitate brain-based design of tailored therapeutic rehabilitation strategies. PMID:21984524

  14. Sub- and Quasi-Centurial Cycles in Solar and Geomagnetic Activity Data Series

    NASA Astrophysics Data System (ADS)

    Komitov, B.; Sello, S.; Duchlev, P.; Dechev, M.; Penev, K.; Koleva, K.

    2016-07-01

    The subject of this paper is the existence and stability of solar cycles with durations in the range of 20-250 years. Five types of data series are used: 1) the Zurich series (1749-2009 AD), the mean annual International sunspot number Ri, 2) the Group sunspot number series Rh (1610-1995 AD), 3) the simulated extended sunspot number from Extended time series of Solar Activity Indices (ESAI) (1090-2002 AD), 4) the simulated extended geomagnetic aa-index from ESAI (1099-2002 AD), 5) the Meudon filament series (1919-1991 AD). Two principally independent methods of time series analysis are used: the T-R periodogram analysis (both in standard and ``scanning window'' regimes) and the wavelet-analysis. The obtained results are very similar. A strong cycle with a mean duration of 55-60 years is found to exist in all series. On the other hand, a strong and stable quasi 110-120 years and ˜200-year cycles are obtained in all of these series except in the Ri one. The high importance of the long term solar activity dynamics for the aims of solar dynamo modeling and predictions is especially noted.

  15. Development of 23 Cycles Activity in Northern and Southern Hemispheres of the Sun

    NASA Astrophysics Data System (ADS)

    Ryabov, M. I.; Sukharev, A. L.; Lukashuk, S. A.

    On an example of the 23rd cycle of solar activity the basic properties of its development in northern and southern hemispheres were researched (daily values of Wolf Sunspot Number - W, the daily values of Sun spots areas - Sp and daily values of flare index - FI.) Effects of application of full-scale Wavelet analysis for studying the temporary structure of formation of a solar cycle show the difference in northern and southern hemispheres. The "leading" periods (in northern hemisphere - 340 days, and in southern hemisphere - 709 days) differ. Thus, the activity period in two years is predominate in southern hemisphere. The "leading" period for the flare index for northern hemisphere is 555 days, and for southern hemisphere is 709 days. In general the basic periods W in northern hemisphere are in the range of 37-555 days, and in southern - 78-906 days, SpN (61-906 days), SpS (61-1477 days), FIN (37-555 days), FIS (23-709 days), FIS - (14709 days) depending on the phase of solar cycle.

  16. Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes

    SciTech Connect

    Fyrberg, Anna; Albertioni, Freidoun; Lotfi, Kourosh . E-mail: koulo@imv.liu.se

    2007-06-15

    Deoxynucleoside analogues (dNAs) are cytotoxic towards both replicating and indolent malignancies. The impact of fluctuations in the metabolism of dNAs in relation to cell cycle could have strong implications regarding the activity of dNAs. Deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) are important enzymes for phosphorylation/activation of dNAs. These drugs can be dephosphorylated/deactivated by 5'-nucleotidases (5'-NTs) and elevated activities of 5'-NTs and decreased dCK and/or dGK activities represent resistance mechanisms towards dNAs. The activities of dCK, dGK, and three 5'-NTs were investigated in four human leukemic cell lines in relationship to cell cycle progression and cytotoxicity of dNAs. Synchronization of cell cultures to arrest in G0/G1 by serum-deprivation was performed followed by serum-supplementation for cell cycle progression. The activities of dCK and dGK increased up to 3-fold in CEM, HL60, and MOLT-4 cells as they started to proliferate, while the activity of cytosolic nucleotidase I was reduced in proliferating cells. CEM, HL60, and MOLT-4 cells were also more sensitive to cladribine, cytarabine, 9-{beta}-D-arabinofuranosylguanine and clofarabine than K562 cells which demonstrated lower levels and less alteration of these enzymes and were least susceptible to the cytotoxic effects of most dNAs. The results suggest that, in the cell lines studied, the proliferation process is associated with a general shift in the direction of activation of dNAs by inducing activities of dCK/dGK and reducing the activity of cN-I which is favourable for the cytotoxic effects of cladribine, cytarabine and, 9-{beta}-D-arabinofuranosylguanine. These results emphasize the importance of cellular proliferation and dNA metabolism by both phosphorylation and dephosphorylation for susceptibility to dNAs. It underscores the need to understand the mechanisms of action and resistance to dNAs in order to increase efficacy of dNAs treatment by new rational.

  17. Recent Activities in Research of the Combined Cycle Engine at JAXA

    NASA Astrophysics Data System (ADS)

    Tani, Kouichiro; Tomioka, Sadatake; Kato, Kanenori; Ueda, Syuichi; Takegoshi, Masao

    Recent activities of the researches on the rocket based combined cycle engine in Japan Aerospace Exploration Agency are summarized. Aiming to realize the flight test in 10 years, JAXA has been making sub-scale model experiments as well as a series of component tests. In 08 fiscal year, sub-scale tests were carried out in Mach 6 flight condition and the stable ramjet combustion was confirmed following the successful ramjet mode establishment in Mach 4 condition in previous year. Some improvements of flow modeling inside the combustor and the ejector analysis were also achieved. With the scramjet mode analysis due in ’09 fiscal year, the designing method of the combined cycle engine will be improved and the next test engine will be launched.

  18. Dynamo-based scheme for forecasting the magnitude of solar activity cycles

    NASA Technical Reports Server (NTRS)

    Layden, A. C.; Fox, P. A.; Howard, J. M.; Sarajedini, A.; Schatten, K. H.

    1991-01-01

    This paper presents a general framework for forecasting the smoothed maximum level of solar activity in a given cycle, based on a simple understanding of the solar dynamo. This type of forecasting requires knowledge of the sun's polar magnetic field strength at the preceding activity minimum. Because direct measurements of this quantity are difficult to obtain, the quality of a number of proxy indicators already used by other authors is evaluated, which are physically related to the sun's polar field. These indicators are subjected to a rigorous statistical analysis, and the analysis technique for each indicator is specified in detail in order to simplify and systematize reanalysis for future use. It is found that several of these proxies are in fact poorly correlated or uncorrelated with solar activity, and thus are of little value for predicting activity maxima. Also presented is a scheme in which the predictions of the individual proxies are combined via an appropriately weighted mean to produce a compound prediction. The scheme is then applied to the current cycle 22, and a maximum smoothed international sunspot number of 171 + or - 26 is estimated.

  19. Observations of hysteresis in solar cycle variations among seven solar activity indicators

    NASA Technical Reports Server (NTRS)

    Bachmann, Kurt T.; White, Oran R.

    1994-01-01

    We show that smoothed time series of 7 indices of solar activity exhibit significant solar cycle dependent differences in their relative variations during the past 20 years. In some cases these observed hysteresis patterns start to repeat over more than one solar cycle, giving evidence that this is a normal feature of solar variability. Among the indices we study, we find that the hysteresis effects are approximately simple phase shifts, and we quantify these phase shifts in terms of lag times behind the leading index, the International Sunspot Number. Our measured lag times range from less than one month to greater than four months and can be much larger than lag times estimated from short-term variations of these same activity indices during the emergence and decay of major active regions. We argue that hysteresis represents a real delay in the onset and decline of solar activity and is an important clue in the search for physical processes responsible for changing solar emission at various wavelengths.

  20. Enriching step-based product information models to support product life-cycle activities

    NASA Astrophysics Data System (ADS)

    Sarigecili, Mehmet Ilteris

    The representation and management of product information in its life-cycle requires standardized data exchange protocols. Standard for Exchange of Product Model Data (STEP) is such a standard that has been used widely by the industries. Even though STEP-based product models are well defined and syntactically correct, populating product data according to these models is not easy because they are too big and disorganized. Data exchange specifications (DEXs) and templates provide re-organized information models required in data exchange of specific activities for various businesses. DEXs show us it would be possible to organize STEP-based product models in order to support different engineering activities at various stages of product life-cycle. In this study, STEP-based models are enriched and organized to support two engineering activities: materials information declaration and tolerance analysis. Due to new environmental regulations, the substance and materials information in products have to be screened closely by manufacturing industries. This requires a fast, unambiguous and complete product information exchange between the members of a supply chain. Tolerance analysis activity, on the other hand, is used to verify the functional requirements of an assembly considering the worst case (i.e., maximum and minimum) conditions for the part/assembly dimensions. Another issue with STEP-based product models is that the semantics of product data are represented implicitly. Hence, it is difficult to interpret the semantics of data for different product life-cycle phases for various application domains. OntoSTEP, developed at NIST, provides semantically enriched product models in OWL. In this thesis, we would like to present how to interpret the GD & T specifications in STEP for tolerance analysis by utilizing OntoSTEP.

  1. A mechanistic examination of redox cycling activity in carbonaceous particulate matter

    NASA Astrophysics Data System (ADS)

    McWhinney, Robert David

    Mechanistic aspects of carbonaceous aerosol toxicity were examined with respect to the ability of particles to catalyse reactive oxygen species-generating redox cycling reactions. To investigate the role of secondary organic material, we examined two systems. In the first, two-stroke engine exhaust particles were found to increase their ability to catalyse redox cycling in the presence of a reducing agent, dithiothreitol (DTT), when the exhaust was exposed to ozone. This occurred through deposition of redox-active secondary organic aerosol (SOA) onto the particle that was ten times more redox active per microgram than the primary engine particle. In the second system, naphthalene SOA formed highly redox active particles. Activity was strongly correlated to the amount of the 1,4- and 1,2-naphthoquinone measured in the particle phase. However, these species and the newly quantified naphthalene oxidation product 5-hydroxy-1,4-naphthoquinone accounted for only 30% of the observed DTT decay from the particles. Gas-particle partitioning coefficients suggest 1,4- and 1,2- naphthoquinone are not strong contributors to ambient particle redox activity at 25 °C. However, a large number of redox active species are unidentified. Some of these may be highly oxidised products of sufficiently low vapour pressure to be atmospherically relevant. DTT activity of diesel particles was found to be high per unit mass. The activity was found to be associated with the insoluble fraction as filtration of the particles nearly eliminated DTT decay. Neither methanol nor dichloromethane extracts of diesel particles exhibited redox activity, indicating that the redox active species are associated with the black carbon portion of the particles. Examination of particle concentration techniques found that use of water condensation to grow and concentrate particles introduced a large organic artefact to the particles. Experiments with concentrated inorganic particles suggest that the source of this

  2. North-south asymmetry in small and large sunspot group activity and violation of even-odd solar cycle rule

    NASA Astrophysics Data System (ADS)

    Javaraiah, J.

    2016-07-01

    According to Gnevyshev-Ohl (G-O) rule an odd-numbered cycle is stronger than its preceding even-numbered cycle. In the modern time the cycle pair (22, 23) violated this rule. By using the combined Greenwich Photoheliographic Results (GPR) and Solar Optical Observing Network (SOON) sunspot group data during the period 1874-2015, and Debrecen Photoheliographic Data (DPD) of sunspot groups during the period 1974-2015, here we have found that the solar cycle pair (22, 23) violated the G-O rule because, besides during cycle 23 a large deficiency of small sunspot groups in both the northern and the southern hemispheres, during cycle 22 a large abundance of small sunspot groups in the southern hemisphere. In the case of large and small sunspot groups the cycle pair (22, 23) violated the G-O rule in the northern and southern hemispheres, respectively, suggesting the north-south asymmetry in solar activity has a significant contribution in the violation of G-O rule. The amplitude of solar cycle 24 is smaller than that of solar cycle 23. However, Coronal Mass Ejections (CMEs) rate in the rising phases of the cycles 23 and 24 are almost same (even slightly large in cycle 24). From both the SOON and the DPD sunspot group data here we have also found that on the average the ratio of the number (counts) of large sunspot groups to the number of small sunspot groups is larger in the rising phase of cycle 24 than that in the corresponding phase of cycle 23. We suggest this could be a potential reason for the aforesaid discrepancy in the CME rates during the rising phases of cycles 23 and 24. These results have significant implication on solar cycle mechanism.

  3. Echocardiographic Diagnosis of Incidentally Found Left Coronary Artery to Pulmonary Artery Fistula in an 11-Year-Old Girl

    PubMed Central

    Chen, Bo-Hau; Lin, Chu-Chuan; Weng, Ken-Pen; Wu, Huang-Wei; Chien, Jen-Hung; Huang, Shih-Ming

    2016-01-01

    We report on a healthy 11-year-old girl who presented to our facility with sudden onset of fainting in a strenuous running course. Transthoracic echocardiography at short-axis view showed a diastolic flow into the main pulmonary artery (PA). The diagnosis of left anterior descending artery (LAD) to PA fistula was documented by cardiac computed tomography and catheterization. Interventional therapy of LAD to the main PA fistula was not performed because of no evidence of myocardial ischemia or significant hemodynamic change. Presently, the patient remains asymptomatic. Coronary fistula with an incidence of about 0.1-0.8% is very rare and may be undetected, particularly in pediatric patients without cardiac murmur. We herein describe the diagnostic approach and discuss the current treatment modalities. PMID:27274178

  4. Echocardiographic Diagnosis of Incidentally Found Left Coronary Artery to Pulmonary Artery Fistula in an 11-Year-Old Girl.

    PubMed

    Chen, Bo-Hau; Lin, Chu-Chuan; Weng, Ken-Pen; Wu, Huang-Wei; Chien, Jen-Hung; Huang, Shih-Ming

    2016-05-01

    We report on a healthy 11-year-old girl who presented to our facility with sudden onset of fainting in a strenuous running course. Transthoracic echocardiography at short-axis view showed a diastolic flow into the main pulmonary artery (PA). The diagnosis of left anterior descending artery (LAD) to PA fistula was documented by cardiac computed tomography and catheterization. Interventional therapy of LAD to the main PA fistula was not performed because of no evidence of myocardial ischemia or significant hemodynamic change. Presently, the patient remains asymptomatic. Coronary fistula with an incidence of about 0.1-0.8% is very rare and may be undetected, particularly in pediatric patients without cardiac murmur. We herein describe the diagnostic approach and discuss the current treatment modalities. PMID:27274178

  5. Caregiver perceptions of the food marketing environment of African-American 3–11-year-olds: a qualitative study

    PubMed Central

    Baskin, Monica L; Herbey, Ivan; Williams, Ronnie; Ard, Jamy D; Ivankova, Nataliya; Odoms-Young, Angela

    2014-01-01

    Objective To assess caregivers’ perceptions of the extent to which the food marketing environment influences food consumption among African-American children (aged 3–11 years) in order to generate potential strategies to make the marketing environment more favourable to healthier eating. Design Individual semi-structured interviews with caregivers were conducted by trained community leaders to ascertain their awareness of and perceptions about food marketing environments contributing to African-American children’s food consumption. Setting Six predominantly African-American communities in metro Birmingham, Alabama, USA with high proportions of school-age children and lower-income residents. Subjects Caregivers (n 25) were predominantly female (93 %) and either parents/guardians (64 %) or grandparents (28 %) of African-American children aged 3–11 years. Caregiver mean age was 43 years and 46% had lived in their current residence for over 10 years. Results Caregivers reported all aspects of the food marketing matrix as supporting unhealthy eating among African-American youth. Child preference for foods higher in fat and sugar, lower pricing of less healthy foods, limited access to healthier food retailers and targeted advertisements were particularly influential on the food selection, acquisition and consumption of children. Company loyalty, corporate sponsorship of local events and conflicts over parental v. food company responsibility contributed to less consensus about the overall impact (positive or negative) of food companies in African-American communities. Conclusions While caregivers perceived aspects of their food marketing environments as primarily contributing to unhealthy eating among African-American children, framing the demand for changes in the food marketing environments of African-American youth may be particularly challenging. PMID:23830058

  6. Change in waist circumference over 11 years and current waist circumference independently predict elevated CRP in Filipino women

    PubMed Central

    Rutherford, J.N.; McDade, T.W.; Lee, N.R.; Adair, L.; Kuzawa, C.

    2012-01-01

    C-reactive protein, a marker of chronic, low-grade inflammation, is strongly associated with current central adiposity, and has been linked to elevated risk of cardiovascular disease. Less is known about the contribution of longitudinal change in waist circumference to current inflammation. We evaluated the extent to which current waist circumference and change over an 11-year interval contribute independently to low-grade systemic inflammation measured in a group of 1,294 women, 35–69 years, participating in the Cebu Longitudinal Nutrition and Health Survey in the Philippines. Waist circumference was measured at the time of blood draw for CRP analysis in 2005 and during an earlier survey in 1994. A waist circumference delta variable was constructed by subtracting current circumference from past circumference. We used logistic regression models to predict having an elevated plasma CRP concentration (3 mg/L11 years was a significant and independent predictor of elevated CRP risk (OR=1.023, 95% CI=1.00,1.05, P<0.05). Considering the average increase over time, the cumulative risk of elevated CRP due to increased central adiposity was 20.1%. However, women who reduced their waist circumference between 1994 and 2005 had greatly reduced risk (6.2%), suggesting that even long-term inflammatory burden can be reversed by weight loss. Although current waist circumference is an important contributor to risk of elevated systemic inflammation in this as in other populations, history of central adiposity may be an independent phenomenon. PMID:19856425

  7. Injuries, Death, and Disability Associated with 11 Years of Conflict in Baghdad, Iraq: A Randomized Household Cluster Survey

    PubMed Central

    Lafta, Riyadh; Al-Shatari, Sahar; Cherewick, Megan; Galway, Lindsay; Mock, Charles; Hagopian, Amy; Flaxman, Abraham; Takaro, Tim; Greer, Anna; Kushner, Adam; Burnham, Gilbert

    2015-01-01

    Background The objective of this study was to characterize injuries, deaths, and disabilities arising during 11 years of conflict in Baghdad. Methods Using satellite imagery and administrative population estimated size for Baghdad, 30 clusters were selected, proportionate to population size estimates. Interviews were conducted during April and May 2014 in 900 households containing 5148 persons. Details about injuries and disabilities occurring from 2003 through May 2014 and resultant disabilities were recorded. Findings There were 553 injuries reported by Baghdad residents, 225 of which were intentional, and 328 unintentional. For intentional injuries, the fatality rate was 39.1% and the disability rate 56.0%. Gunshots where the major cause of injury through 2006 when blasts/explosions became the most common cause and remained so through 2014. Among unintentional injuries, the fatality rate was 7.3% and the disability rate 77.1%. The major cause of unintentional injuries was falls (131) which have increased dramatically since 2008, followed by traffic related injuries (81), which have steadily increased. The proportion of injuries ending in disabilities remained fairly constant through the survey period. Interpretation Intentional injuries added substantially to the burden of unintentional injuries for the population. For Baghdad, the phases of the Iraqi conflict are reflected in the patterns of injuries and consequent deaths reported. The scale of injuries during conflict is most certainly under-reported. Difficulties recalling injuries in a survey covering 11 years is a limitation, but it is likely that minor injuries were under-reported more than severe injuries. The in- and out-migration of Baghdad populations likely had effects on the events reported which we could not measure or estimate. Damage to the health infrastructure and the flight of health workers may have contributed to mortality and morbidity. Civilian injuries as well as mortality should be

  8. A longitudinal study of grapheme-color synesthesia in childhood: 6/7 years to 10/11 years

    PubMed Central

    Simner, Julia; Bain, Angela E.

    2013-01-01

    Grapheme-color synesthesia is a condition characterized by enduring and consistent associations between letter/digits and colors. This study is the continuation of longitudinal research begun by Simner et al. (2009) which aimed to explore the development of this condition in real time within a childhood population. In that earlier study we randomly sampled over 600 children and tested them aged 6/7 and 7/8 years. We identified the child synesthetes within that cohort and measured their development over 1 year, in comparison to a group of non-synesthetic children with both average and superior memories. We were able to show the beginnings of a developmental progression in which synesthetic associations (e.g., A = red) mature over time from relatively chaotic pairings into a system of fixed consistent associations. In the current study we return to this same population three years later when participants are now 10/11 years. We used the same paired-association memory task to determine the synesthetic status of our participants and to also establish synesthetes' inventories of grapheme-color associations. We compared their inventories to those from age 6/7 and 7/8 years to examine how synesthesia matures over time. Together with earlier findings, our study shows that grapheme-color synesthesia emerges with a protracted trajectory, with 34% of letters/digits fixed at age 6/7 years, 48% fixed at 7/8 years and 71% fixed at 10/11 years. We also show several cases where synesthesia is not developing in the same time-frame as peers, either because it has died out at an older age, or because it was slower to develop than other cases. Our study paints the first picture of the emergence of synesthesia in real-time over four years within a randomly sampled population of child synesthetes. PMID:24312035

  9. Solar activity phase diagram and forecast of the coming 23rd cycle.

    NASA Astrophysics Data System (ADS)

    Pankratov, A. K.; Narmanskij, V. Ya.; Vladimirskij, B. M.

    1998-10-01

    The phase diagram method is used for investigation of relations between planetary dynamics and solar activity variations. It was found that the calculated moments of solar activity maxima/minima are disposed regularly in the coordinates of the difference of heliocentric longitudes of Uranus-Neptune versus the difference of heliocentric longitudes of Saturn-Neptune. There are separate zones containing maxima (minima) of only the northern (or southern) polarity of solar mean magnetic field. There is also a region where only maxima of small amplitudes are concentrated (Rz < 100). The regularities obtained are used for prognosis of the 23rd cycle. The minimum of activity must be observed in 1999±2. The maximum is forecast in 2006±2. The amplitude Rz can be as small as 60±20. Probably there will be no change of the polarity of the mean solar magnetic field.

  10. Photometric Variations in Spotted Pleiades Stars as Probes of Long-Term Activity Cycles

    NASA Astrophysics Data System (ADS)

    Bardenett, E.; Milingo, J. B.; Marschall, L. A.; Backman, D. E.

    2004-12-01

    Through the collaborative efforts of undergraduates and faculty at Franklin & Marshall and Gettysburg Colleges, we present new photometric data for 3 K-type stars in the Pleiades. Continuing 8+ years of observations, this data contributes to the long-term study of photometric variations in these stars. These young stars have rotational light curves with V-band amplitudes of a few percent (up to 10% in the most active stars) due to large photospheric active regions or "starspots". Quantifying the level of starspot activity from year to year allows us to look for long-term trends analogous to the solar sunspot cycle. These observations were acquired with the National Undergraduate Research Observatory's (NURO) 31" telescope, which is operated by Lowell Observatory and Northern Arizona University. This work is supported by Franklin & Marshall College, the Delaware Space Grant Consortium, and Arizona Space Grant (NASA Space Grant programs).

  11. North-south asymmetry of different solar activity features during solar cycle 23

    NASA Astrophysics Data System (ADS)

    Bankoti, Neeraj Singh; Joshi, Navin Chandra; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2010-08-01

    A study on north-south (N-S) asymmetry of different solar activity features (DSAF) such as solar proton events, solar active prominences [total, low (⩽40°) and high (⩾50°) latitudes], H α flare indices, soft X-ray flares, monthly mean sunspot areas and monthly mean sunspot numbers carried out from May 1996 to October 2008. Study shows a southern dominance of DSAF during this period. During the rising phase of the cycle 23 the number of DSAF approximately equals on both, the northern and the southern hemispheres. But these activities tend to shift from northern to southern hemisphere during the period 1998-1999. The statistical significance of the asymmetry time series using a χ2-test of goodness of fit indicates that in most of the cases the asymmetry is highly significant, meaning thereby that the asymmetry is a real feature in the N-S distribution of DSAF.

  12. Endometrial phospholipase A2 activity during the oestrous cycle and early pregnancy in mares.

    PubMed

    Ababneh, M M; Troedsson, M H T

    2013-02-01

    The aim of this study was to determine phospholipase A2 (PLA2) kinetics and activity in the mare's endometrium during the oestrous cycle and early pregnancy. Phospholipase A2 is responsible for the liberation of arachidonic acid from phospholipids, which is the first limiting step in prostaglandins synthesis. Phospholipase A2 activity was measured using an assay based on the liberation of oleic acid from 1-palmitoyl-2-[(14) C] oleoyl phosphatidylcholine. The enzyme was shown to be calcium dependent, to have an optimum pH of 8 and an apparent Michaelis constant of 127 μM. Enzyme activity was low in the endometrium of early luteal phase tissue but increased significantly (p < 0.001) during the late luteal phase (5.39 ± 0.16; 3.48 ± 0.33, 6.85 ± 0.59, and 9.96 ± 1.23 nmol oleic acid released/mg protein at oestrus, and Days 3, 8 and 14 after ovulation, respectively). The mean PLA2 activity in endometrial tissue from pregnant mares (4.23 ± 0.74) was significantly lower (p < 0.01) than from cyclic animals during late dioestrus (9.96 ± 1.23). The results indicate that PLA2 activity in equine endometrium changes with the stage of the oestrous cycle and thus may be influenced by systemic hormone concentrations. The inhibitory effects of conceptus products on secretion of prostaglandin during early pregnancy were associated with a competitive inhibitor that decreased endometrial PLA2 activity. PMID:22486770

  13. Changes in Voluntary Activation Assessed by Transcranial Magnetic Stimulation during Prolonged Cycling Exercise

    PubMed Central

    Perrey, Stephane; Temesi, John; Wuyam, Bernard; Levy, Patrick; Verges, Samuel; Millet, Guillaume Y.

    2014-01-01

    Maximal central motor drive is known to decrease during prolonged exercise although it remains to be determined whether a supraspinal deficit exists, and if so, when it appears. The purpose of this study was to evaluate corticospinal excitability and muscle voluntary activation before, during and after a 4-h cycling exercise. Ten healthy subjects performed three 80-min bouts on an ergocycle at 45% of their maximal aerobic power. Before exercise and immediately after each bout, neuromuscular function was evaluated in the quadriceps femoris muscles under isometric conditions. Transcranial magnetic stimulation was used to assess voluntary activation at the cortical level (VATMS), corticospinal excitability via motor-evoked potential (MEP) and intracortical inhibition by cortical silent period (CSP). Electrical stimulation of the femoral nerve was used to measure voluntary activation at the peripheral level (VAFNES) and muscle contractile properties. Maximal voluntary force was significantly reduced after the first bout (13±9%, P<0.01) and was further decreased (25±11%, P<0.001) at the end of exercise. CSP remained unchanged throughout the protocol. Rectus femoris and vastus lateralis but not vastus medialis MEP normalized to maximal M-wave amplitude significantly increased during cycling. Finally, significant decreases in both VATMS and VAFNES (∼8%, P<0.05 and ∼14%, P<0.001 post-exercise, respectively) were observed. In conclusion, reductions in VAFNES after a prolonged cycling exercise are partly explained by a deficit at the cortical level accompanied by increased corticospinal excitability and unchanged intracortical inhibition. When comparing the present results with the literature, this study highlights that changes at the cortical and/or motoneuronal levels depend not only on the type of exercise (single-joint vs. whole-body) but also on exercise intensity and/or duration. PMID:24586559

  14. Probing the Electrostatics of Active Site Microenvironments along the Catalytic Cycle for Escherichia coli Dihydrofolate Reductase

    PubMed Central

    2015-01-01

    Electrostatic interactions play an important role in enzyme catalysis by guiding ligand binding and facilitating chemical reactions. These electrostatic interactions are modulated by conformational changes occurring over the catalytic cycle. Herein, the changes in active site electrostatic microenvironments are examined for all enzyme complexes along the catalytic cycle of Escherichia coli dihydrofolate reductase (ecDHFR) by incorporation of thiocyanate probes at two site-specific locations in the active site. The electrostatics and degree of hydration of the microenvironments surrounding the probes are investigated with spectroscopic techniques and mixed quantum mechanical/molecular mechanical (QM/MM) calculations. Changes in the electrostatic microenvironments along the catalytic environment lead to different nitrile (CN) vibrational stretching frequencies and 13C NMR chemical shifts. These environmental changes arise from protein conformational rearrangements during catalysis. The QM/MM calculations reproduce the experimentally measured vibrational frequency shifts of the thiocyanate probes across the catalyzed hydride transfer step, which spans the closed and occluded conformations of the enzyme. Analysis of the molecular dynamics trajectories provides insight into the conformational changes occurring between these two states and the resulting changes in classical electrostatics and specific hydrogen-bonding interactions. The electric fields along the CN axes of the probes are decomposed into contributions from specific residues, ligands, and solvent molecules that make up the microenvironments around the probes. Moreover, calculation of the electric field along the hydride donor–acceptor axis, along with decomposition of this field into specific contributions, indicates that the cofactor and substrate, as well as the enzyme, impose a substantial electric field that facilitates hydride transfer. Overall, experimental and theoretical data provide evidence for

  15. Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis.

    PubMed

    Sontakke, Vyankat A; Lawande, Pravin P; Kate, Anup N; Khan, Ayesha; Joshi, Rakesh; Kumbhar, Anupa A; Shinde, Vaishali S

    2016-04-26

    An efficient route was developed for synthesis of bicyclic benzimidazole nucleosides from readily available d-glucose. The key reactions were Vörbruggen glycosylation and ring closing metathesis (RCM). Primarily, to understand the mode of DNA binding, we performed a molecular docking study and the binding was found to be in the minor groove region. Based on the proposed binding model, UV-visible and fluorescence spectroscopic techniques using calf thymus DNA (CT-DNA) demonstrated a non-intercalative mode of binding. Antiproliferative activity of nucleosides was tested against MCF-7 and MDA-MB-231 breast cancer cell lines and found to be active at low micromolar concentrations. Compounds and displayed significant antiproliferative activity as compared to and with the reference anticancer drug, doxorubicin. Cell cycle analysis showed that nucleoside induced cell cycle arrest at the S-phase. Confocal microscopy has been performed to validate the induction of cellular apoptosis. Based on these findings, such modified bicyclic benzimidazole nucleosides will make a significant contribution to the development of anticancer drugs. PMID:27074628

  16. Kinetic energy budgets during the life cycle of intense convective activity

    NASA Technical Reports Server (NTRS)

    Fuelberg, H. E.; Scoggins, J. R.

    1978-01-01

    Synoptic-scale data at three- and six-hour intervals are employed to study the relationship between changing kinetic energy variables and the life cycles of two severe squall lines. The kinetic energy budgets indicate a high degree of kinetic energy generation, especially pronounced near the jet-stream level. Energy losses in the storm environment are due to the transfer of kinetic energy from grid to subgrid scales of motion; large-scale upward vertical motion carries aloft the kinetic energy generated by storm activity at lower levels. In general, the time of maximum storm intensity is also the time of maximum energy conversion and transport.

  17. On the Relationship Between Solar Wind Speed, Geomagnetic Activity, and the Solar Cycle Using Annual Values

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    The aa index can be decomposed into two separate components: the leading sporadic component due to solar activity as measured by sunspot number and the residual or recurrent component due to interplanetary disturbances, such as coronal holes. For the interval 1964-2006, a highly statistically important correlation (r = 0.749) is found between annual averages of the aa index and the solar wind speed (especially between the residual component of aa and the solar wind speed, r = 0.865). Because cyclic averages of aa (and the residual component) have trended upward during cycles 11-23, cyclic averages of solar wind speed are inferred to have also trended upward.

  18. Investigating the Potential of Activity Tracking App Data to Estimate Cycle Flows in Urban Areas

    NASA Astrophysics Data System (ADS)

    Haworth, J.

    2016-06-01

    Traffic congestion and its associated environmental effects pose a significant problem for large cities. Consequently, promoting and investing in green travel modes such as cycling is high on the agenda for many transport authorities. In order to target investment in cycling infrastructure and improve the experience of cyclists on the road, it is important to know where they are. Unfortunately, investment in intelligent transportation systems over the years has mainly focussed on monitoring vehicular traffic, and comparatively little is known about where cyclists are on a day to day basis. In London, for example, there are a limited number of automatic cycle counters installed on the network, which provide only part of the picture. These are supplemented by surveys that are carried out infrequently. Activity tracking apps on smart phones and GPS devices such as Strava have become very popular over recent years. Their intended use is to track physical activity and monitor training. However, many people routinely use such apps to record their daily commutes by bicycle. At the aggregate level, these data provide a potentially rich source of information about the movement and behaviour of cyclists. Before such data can be relied upon, however, it is necessary to examine their representativeness and understand their potential biases. In this study, the flows obtained from Strava Metro (SM) are compared with those obtained during the 2013 London Cycle Census (LCC). A set of linear regression models are constructed to predict LCC flows using SM flows along with a number of dummy variables including road type, hour of day, day of week and presence/absence of cycle lane. Cross-validation is used to test the fitted models on unseen LCC sites. SM flows are found to be a statistically significant (p<0.0001) predictor of total flows as measured by the LCC and the models yield R squared statistics of ~0.7 before considering spatio-temporal variation. The initial results indicate

  19. Principal Component Analysis of Solar Background and Sunspot Magnetic Field in cycles 21-24 and its implications for the solar activity prediction in cycles 25-27

    NASA Astrophysics Data System (ADS)

    Zharkova, Valentina; Popova, Helen; Zharkov, Sergei; Shepherd, Simon

    Principle component analysis (PCA) of the solar background magnetic field (SBMF) measured from Wilcox Solar Observatory (WSO) and sunspot magnetic field (SMF) measured by SOHO/MDI magnetograms reveals the two principal components (PCs) of waves travelling in time. In addition, the independent components analysis helps to uncover 8 pairs of SBMF waves in latitudes: two large symmetric magnetic waves , which are the same for all cycles 21-23, and three pairs of asymmetric magnetic waves, which are unique for each cycle. In each pair the waves travel slightly off phase with different phase shift for each cycle and have a different number of equator crossings (Zharkova et al, 2012). These SBMF variations are assumed to be those of poloidal magnetic field traveling slightly off-phase from pole to pole which are caused by a joint action of dipole and quadruple magnetic sources in the Sun. The simulations with the two layer Parker's dynamo model with meridional circulation revealed that the dominant pair of PCs can be produced by a magnetic dipole accounting for the two main dynamo waves operating between the two magnetic poles. The further three pairs of the waves are unique to each cycle and associated with the multiple magnetic sources in the solar interior: with a quadruple symmetry in both layers for cycle 21, with quadruple magnetic sources in the upper layer and dipole sources in the inner layer for cycle 22 and with the quadruple magnetic sources in the inner layer and the dipole sources in the upper layer for cycle 23 (Popova et al, 2013). The PCs derived for all three cycles from SMBF were used as a training set for the magnetic wave prediction for the cycles 24-27 by using Hamiltonian approach (Shepherd and Zharkova, 2014) and verifying by the SBMF observations in the current cycle 24. The prediction results indicate that the solar activity is defined mainly by the solar background magnetic fields while the sunspots and their magnetic fields seem to be

  20. [Ascorbate-glutathione cycle enzymes activity in Zea mays leaves under salinity and treatment by adaptogenic compounds].

    PubMed

    Konturs'ka, O O; Palladina, T O

    2012-01-01

    The effect of different salinity levels and synthetic compounds treatments on ascorbate-glutathione cycle enzymes activity in maize leaves has been investigated. One-day seedlings exposition with 0.05 M NaCl increased ascorbate peroxidase activity, whereas 10-day exposition did not affect it. However the exposition with 0.1 M NaCl, which is extreme for maize, decreased ascorbate peroxidase activity in leaves during 10 days. On the other hand glutathione reductase activity in leaves increased under both salt concentrations. Seeds treatments with Methyure and Ivine increased ascorbate peroxidase activity in the leaves of seedlings under 0.1 M NaCl, but did not affect glutathione reductase activity as compared to the salt control. The results obtained have shown differences of ascorbate-glutathione cycle enzymes responses to salt exposition of seedlings and the effects of adaptogenic compounds on the ascorbate-glutathione cycle via ascorbate peroxidase activation. PMID:23387279

  1. Cycles of passive versus active diapirism recorded along an exposed salt wall

    NASA Astrophysics Data System (ADS)

    Alsop, G. I.; Weinberger, R.; Levi, T.; Marco, S.

    2016-03-01

    Although it has long been recognised that passive salt diapirism may encompass sub-ordinate cycles of active diapirism, where sedimentary overburden is periodically shed off the roof of the rising salt, there has been very little study of this process around exposed salt (halite) diapirs. However, the Late Miocene-Pliocene Sedom salt wall, on the western side of the Dead Sea Basin, presents an opportunity for detailed outcrop analysis of diapiric salt and the associated depositional and deformational record of its movement during both passive and active phases of diapirism. The sub-seismic scale record of diapirism includes sedimentary breccia horizons interpreted to reflect sediments being shed off the crest of the growing salt wall, together with exceptional preservation of rotated unconformities and growth faults. Areas of more pronounced dips directed towards the salt wall are capped by unconformities, and interpreted to represent withdrawal basins within the overburden that extend for at least 1500 m from the salt margin. Elsewhere, broad areas of upturn directed away from the salt extend for up to 1250 m and are marked by a sequence of rotated unconformities which are interpreted to bound halokinetic sequences. The margins of the salt wall are defined by steep extensional boundary faults that cut upturned strata, and have enabled rapid and active uplift of the salt since the Holocene. The Sedom salt wall therefore charts the transition from passive growth marked by withdrawal basins, growth faults and unconformities, to more active intrusion associated with major boundary faults that enable the rapid uplift of overburden deposited on top of the salt to ∼100 m above regional elevations in the past 43 ka. Individual cycles of passive and active diapirism occur over timescales of <30 ka, which is up to an order of magnitude less than typically suggested for other settings, and highlights the dynamic interplay between salt tectonics and sedimentation in an

  2. Soil Microbial Activity Provides Insight to Carbon Cycling in Shrub Ecotones of Sub-Arctic Sweden

    NASA Astrophysics Data System (ADS)

    Marek, E.; Kashi, N. N.; Chen, J.; Hobbie, E. A.; Schwan, M. R.; Varner, R. K.

    2015-12-01

    Shrubs are expanding in Arctic and sub-Arctic regions due to rising atmospheric temperatures. Microbial activity increases as growing temperatures cause permafrost warming and subsequent thaw, leading to a greater resource of soil nutrients enabling shrub growth. Increased carbon inputs from shrubs is predicted to result in faster carbon turnover by microbial decomposition. Further understanding of microbial activity underneath shrubs could uncover how microbes and soil processes interact to promote shrub expansion and carbon cycling. To address how higher soil carbon input from shrubs influences decomposition, soil samples were taken across a heath, shrub, and forest ecotone gradient at two sites near Abikso, Sweden. Samples were analyzed for soluble carbon and nitrogen, microbial abundance, and microbial activity of chitinase, glucosidase, and phosphatase to reflect organic matter decomposition and availability of nitrogen, carbon, and phosphate respectively. Chitinase activity positively correlated with shrub cover, suggesting microbial demands for nitrogen increase with higher shrub cover. Glucosidase activity negatively correlated with shrub cover and soluble carbon, suggesting decreased microbial demand for carbon as shrub cover and carbon stores increase. Lower glucosidase activity in areas with high carbon input from shrubs implies that microbes are decomposing carbon less readily than carbon is being put into the soil. Increasing soil carbon stores in shrub covered areas can lead to shrubs becoming a net carbon sink and a negative feedback to changing climate.

  3. Dynamo-based simulations of solar activity differences between north and south hemispheres and forecasts for cycle 24

    NASA Astrophysics Data System (ADS)

    Dikpati, M.; Gilman, P. A.; de Toma, G.

    2006-12-01

    Recently we (GRL, 2006, vol.33, L05102, doi:10.1029/2005GL025221) built a predictive tool based on a Babcock-Leighton type flux-transport dynamo model of solar cycle. By assimilating the observed surface magnetic source data since cycle 12, we ran the model and showed that the model can correctly simulate the relative peaks of cycles 16 through 23. Extending the simulation into the future we predicted that cycle 24 will be 30-50 percent stronger than current cycle 23, because a strong 'seed' for cycle 24 is being formed, from the combination of latitudinal fields from past three cycles, 21, 22 and 23, in the dynamo layer in our model. We are currently exploring the data assimilation in our model for the N and S hemispheres separately, in order to simulate hemispheric asymmetries in the solar cycle features. Preliminary results show that the model has skill in simulating the N and S hemispheres separately, as well as the difference between the two hemispheres. We will discuss which hemisphere of the Sun should become more active in cycle 24 and which hemisphere should reach cycle peak first. This work is partially supported by NASA's LWS grant NNH05AB521, SR&T grant NNH06AD51I and the NCAR Director's Opportunity Fund. National Center for Atmospheric Research is sponsored by National Science Foundation.

  4. Increased Mesohippocampal Dopaminergic Activity and Improved Depression-Like Behaviors in Maternally Separated Rats Following Repeated Fasting/Refeeding Cycles

    PubMed Central

    Jahng, Jeong Won; Yoo, Sang Bae; Kim, Jin Young; Kim, Bom-Taeck; Lee, Jong-Ho

    2012-01-01

    We have previously reported that rats that experienced 3 h of daily maternal separation during the first 2 weeks of birth (MS) showed binge-like eating behaviors with increased activity of the hypothalamic-pituitary-adrenal axis when they were subjected to fasting/refeeding cycles repeatedly. In this study, we have examined the psychoemotional behaviors of MS rats on the fasting/refeeding cycles, together with their brain dopamine levels. Fasting/refeeding cycles normalized the ambulatory activity of MS rats, which was decreased by MS experience. Depression-like behaviors, but not anxiety, by MS experience were improved after fasting/refeeding cycles. Fasting/refeeding cycles did not significantly affect the behavioral scores of nonhandled (NH) control rats. Fasting/refeeding cycles increased dopamine levels not only in the hippocampus but also in the midbrain dopaminergic neurons in MS rats, but not in NH controls. Results demonstrate that fasting/refeeding cycles increase the mesohippocampal dopaminergic activity and improve depression-like behaviors in rats that experienced MS. Together with our previous paper, it is suggested that increased dopamine neurotransmission in the hippocampus may be implicated in the underlying mechanisms by which the fasting/refeeding cycles induce binge-like eating and improve depression-like behaviors in MS rats. PMID:22934157

  5. Solar activity during the Holocene: the Hallstatt cycle and its consequence for grand minima and maxima

    NASA Astrophysics Data System (ADS)

    Usoskin, I. G.; Gallet, Y.; Lopes, F.; Kovaltsov, G. A.; Hulot, G.

    2016-03-01

    Aims: Cosmogenic isotopes provide the only quantitative proxy for analyzing the long-term solar variability over a centennial timescale. While essential progress has been achieved in both measurements and modeling of the cosmogenic proxy, uncertainties still remain in the determination of the geomagnetic dipole moment evolution. Here we aim at improving the reconstruction of solar activity over the past nine millennia using a multi-proxy approach. Methods: We used records of the 14C and 10Be cosmogenic isotopes, current numerical models of the isotope production and transport in Earth's atmosphere, and available geomagnetic field reconstructions, including a new reconstruction relying on an updated archeo- and paleointensity database. The obtained series were analyzed using the singular spectrum analysis (SSA) method to study the millennial-scale trends. Results: A new reconstruction of the geomagnetic dipole field moment, referred to as GMAG.9k, is built for the last nine millennia. New reconstructions of solar activity covering the last nine millennia, quantified in terms of sunspot numbers, are presented and analyzed. A conservative list of grand minima and maxima is also provided. Conclusions: The primary components of the reconstructed solar activity, as determined using the SSA method, are different for the series that are based on 14C and 10Be. This shows that these primary components can only be ascribed to long-term changes in the terrestrial system and not to the Sun. These components have therefore been removed from the reconstructed series. In contrast, the secondary SSA components of the reconstructed solar activity are found to be dominated by a common ≈2400-year quasi-periodicity, the so-called Hallstatt cycle, in both the 14C and 10Be based series. This Hallstatt cycle thus appears to be related to solar activity. Finally, we show that the grand minima and maxima occurred intermittently over the studied period, with clustering near lows and highs

  6. Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response

    PubMed Central

    Bujdoso, Raymond; Landgraf, Matthias; Jackson, Walker S; Thackray, Alana M

    2015-01-01

    Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, motor neuron disease, tauopathies and prion diseases. Collectively, these conditions are a challenge to society because of the increasing aged population and through the real threat to human food security by animal prion diseases. It is therefore important to understand the cellular and molecular mechanisms that underlie protein misfolding-induced neurotoxicity as this will form the basis for designing strategies to alleviate their burden. Prion diseases are an important paradigm for neurodegenerative conditions in general since several of these maladies have now been shown to display prion-like phenomena. Increasingly, cell cycle activity and the DNA damage response are recognised as cellular events that participate in the neurotoxic process of various neurodegenerative diseases, and their associated animal models, which suggests they are truly involved in the pathogenic process and are not merely epiphenomena. Here we review the role of cell cycle activity and the DNA damage response in neurodegeneration associated with protein misfolding diseases, and suggest that these events contribute towards prion-induced neurotoxicity. In doing so, we highlight PrP transgenic Drosophila as a tractable model for the genetic analysis of transmissible mammalian prion disease. PMID:26279981

  7. Automated Gastric Slow Wave Cycle Partitioning and Visualization for High-resolution Activation Time Maps

    PubMed Central

    Erickson, Jonathan C.; O’Grady, Greg; Du, Peng; Egbuji, John U.; Pullan, Andrew J.; Cheng, Leo K.

    2014-01-01

    High-resolution (HR) multi-electrode mapping has become an important technique for evaluating gastrointestinal (GI) slow wave (SW) behaviors. However, the application and uptake of HR mapping has been constrained by the complex and laborious task of analyzing the large volumes of retrieved data. Recently, a rapid and reliable method for automatically identifying activation times (ATs) of SWs was presented, offering substantial efficiency gains. To extend the automated data-processing pipeline, novel automated methods are needed for partitioning identified ATs into their propagation cycles, and for visualizing the HR spatiotemporal maps. A novel cycle partitioning algorithm (termed REGROUPS) is presented. REGROUPS employs an iterative REgion GROwing procedure and incorporates a Polynomial-surface-estimate Stabilization step, after initiation by an automated seed selection process. Automated activation map visualization was achieved via an isochronal contour mapping algorithm, augmented by a heuristic 2-step scheme. All automated methods were collectively validated in a series of experimental test cases of normal and abnormal SW propagation, including instances of patchy data quality. The automated pipeline performance was highly comparable to manual analysis, and outperformed a previously proposed partitioning approach. These methods will substantially improve the efficiency of GI HR mapping research. PMID:20927594

  8. Secretly Eccentric: The Giant Planet and Activity Cycle of GJ 328

    NASA Astrophysics Data System (ADS)

    Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Boss, Alan P.

    2013-09-01

    We announce the discovery of a ~2 Jupiter-mass planet in an eccentric 11 yr orbit around the K7/M0 dwarf GJ 328. Our result is based on 10 years of radial velocity (RV) data from the Hobby-Eberly and Harlan J. Smith telescopes at McDonald Observatory, and from the Keck Telescope at Mauna Kea. Our analysis of GJ 328's magnetic activity via the Na I D features reveals a long-period stellar activity cycle, which creates an additional signal in the star's RV curve with amplitude 6-10 m s-1. After correcting for this stellar RV contribution, we see that the orbit of the planet is more eccentric than suggested by the raw RV data. GJ 328b is currently the most massive, longest-period planet discovered around a low-mass dwarf.

  9. Olfactory bulb units - Activity correlated with inhalation cycles and odor quality.

    NASA Technical Reports Server (NTRS)

    Macrides, F.; Chorover, S. L.

    1972-01-01

    Single olfactory bulb units were studied in two macrosmatic species of rodents under conditions intended to preserve the cyclical stimulation which normally accompanies nasal breathing. Patterns of unit activity related to the inhalation cycle were observed in all animals, often in the absence of specific stimuli, and could not be explained in simple mechanical terms. Distinctive changes in these patterns occurred in response to certain odors, and were generally independent of changes in the overall firing frequency. These findings indicate that a change in the overall firing frequency of unit discharges is neither a necessary nor sufficient measure of responsiveness to odors in the rodent olfactory bulb, and that stimulus-specific temporal distributions of unit firing may be involved in olfacto-endocrine activities.

  10. SECRETLY ECCENTRIC: THE GIANT PLANET AND ACTIVITY CYCLE OF GJ 328

    SciTech Connect

    Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Boss, Alan P.

    2013-09-10

    We announce the discovery of a {approx}2 Jupiter-mass planet in an eccentric 11 yr orbit around the K7/M0 dwarf GJ 328. Our result is based on 10 years of radial velocity (RV) data from the Hobby-Eberly and Harlan J. Smith telescopes at McDonald Observatory, and from the Keck Telescope at Mauna Kea. Our analysis of GJ 328's magnetic activity via the Na I D features reveals a long-period stellar activity cycle, which creates an additional signal in the star's RV curve with amplitude 6-10 m s{sup -1}. After correcting for this stellar RV contribution, we see that the orbit of the planet is more eccentric than suggested by the raw RV data. GJ 328b is currently the most massive, longest-period planet discovered around a low-mass dwarf.

  11. The role of circulating sex hormones in menstrual cycle-dependent modulation of pain-related brain activation.

    PubMed

    Veldhuijzen, Dieuwke S; Keaser, Michael L; Traub, Deborah S; Zhuo, Jiachen; Gullapalli, Rao P; Greenspan, Joel D

    2013-04-01

    Sex differences in pain sensitivity have been consistently found, but the basis for these differences is incompletely understood. The present study assessed how pain-related neural processing varies across the menstrual cycle in normally cycling, healthy women, and whether menstrual cycle effects are based on fluctuating sex hormone levels. Fifteen subjects participated in 4 test sessions during their menstrual, midfollicular, ovulatory, and midluteal phases. Brain activity was measured while nonpainful and painful stimuli were applied with a pressure algometer. Serum hormone levels confirmed that scans were performed at appropriate cycle phases in 14 subjects. No significant cycle phase differences were found for pain intensity or unpleasantness ratings of stimuli applied during functional magnetic resonance imaging scans. However, lower pressure pain thresholds were found for follicular compared with other phases. Pain-specific brain activation was found in several regions traditionally associated with pain processing, including the medial thalamus, anterior and middle insula, midcingulate, primary and secondary somatosensory cortices, cerebellum, and frontal regions. The inferior parietal lobule, occipital gyrus, cerebellum, and several frontal regions showed interaction effects between stimulus level and cycle phase, indicating differential processing of pain-related responses across menstrual cycle phases. Correlational analyses indicated that cycle-related changes in pain sensitivity measures and brain activation were only partly explained by varying sex hormone levels. These results show that pain-related cerebral activation varies significantly across the menstrual cycle, even when perceived pain intensity and unpleasantness remain constant. The involved brain regions suggest that cognitive pain or more general bodily awareness systems are most susceptible to menstrual cycle effects. PMID:23528204

  12. The role of circulating sex hormones in menstrual cycle dependent modulation of pain-related brain activation

    PubMed Central

    Veldhuijzen, Dieuwke S.; Keaser, Michael L.; Traub, Deborah S.; Zhuo, Jiachen; Gullapalli, Rao P.; Greenspan, Joel D.

    2013-01-01

    Sex differences in pain sensitivity have been consistently found but the basis for these differences is incompletely understood. The present study assessed how pain-related neural processing varies across the menstrual cycle in normally cycling, healthy females, and whether menstrual cycle effects are based on fluctuating sex hormone levels. Fifteen subjects participated in four test sessions during their menstrual, mid-follicular, ovulatory, and midluteal phases. Brain activity was measured while nonpainful and painful stimuli were applied with a pressure algometer. Serum hormone levels confirmed that scans were performed at appropriate cycle phases in 14 subjects. No significant cycle phase differences were found for pain intensity or unpleasantness ratings of stimuli applied during fMRI scans. However, lower pressure pain thresholds were found for follicular compared to other phases. Pain-specific brain activation was found in several regions traditionally associated with pain processing, including the medial thalamus, anterior and mid-insula, mid-cingulate, primary and secondary somatosensory cortices, cerebellum, and frontal regions. The inferior parietal lobule, occipital gyrus, cerebellum and several frontal regions demonstrated interaction effects between stimulus level and cycle phase, indicating differential processing of pain-related responses across menstrual cycle phases. Correlational analyses indicated that cycle-related changes in pain sensitivity measures and brain activation were only partly explained by varying sex hormone levels. These results show that pain-related cerebral activation varies significantly across the menstrual cycle, even when perceived pain intensity and unpleasantness remain constant. The involved brain regions suggest that cognitive pain or more general bodily awareness systems are most susceptible to menstrual cycle effects. PMID:23528204

  13. Neighborhood walkability and active travel (walking and cycling) in New York City.

    PubMed

    Freeman, Lance; Neckerman, Kathryn; Schwartz-Soicher, Ofira; Quinn, James; Richards, Catherine; Bader, Michael D M; Lovasi, Gina; Jack, Darby; Weiss, Christopher; Konty, Kevin; Arno, Peter; Viola, Deborah; Kerker, Bonnie; Rundle, Andrew G

    2013-08-01

    Urban planners have suggested that built environment characteristics can support active travel (walking and cycling) and reduce sedentary behavior. This study assessed whether engagement in active travel is associated with neighborhood walkability measured for zip codes in New York City. Data were analyzed on engagement in active travel and the frequency of walking or biking ten blocks or more in the past month, from 8,064 respondents to the New York City 2003 Community Health Survey (CHS). A neighborhood walkability scale that measures: residential, intersection, and subway stop density; land use mix; and the ratio of retail building floor area to retail land area was calculated for each zip code. Data were analyzed using zero-inflated negative binomial regression incorporating survey sample weights and adjusting for respondents' sociodemographic characteristics. Overall, 44 % of respondents reported no episodes of active travel and among those who reported any episode, the mean number was 43.2 episodes per month. Comparing the 75th to the 25th percentile of zip code walkability, the odds ratio for reporting zero episodes of active travel was 0.71 (95 % CI 0.61, 0.83) and the exponentiated beta coefficient for the count of episodes of active travel was 1.13 (95 % CI 1.06, 1.21). Associations between lower walkability and reporting zero episodes of active travel were significantly stronger for non-Hispanic Whites as compared to non-Hispanic Blacks and to Hispanics and for those living in higher income zip codes. The results suggest that neighborhood walkability is associated with higher engagement in active travel. PMID:22941058

  14. Flux-tube geometry and solar wind speed during an activity cycle

    NASA Astrophysics Data System (ADS)

    Pinto, R. F.; Brun, A. S.; Rouillard, A. P.

    2016-07-01

    Context. The solar wind speed at 1 AU shows cyclic variations in latitude and in time which reflect the evolution of the global background magnetic field during the activity cycle. It is commonly accepted that the terminal (asymptotic) wind speed in a given magnetic flux-tube is generally anti-correlated with its total expansion ratio, which motivated the definition of widely used semi-empirical scaling laws relating one to the other. In practice, such scaling laws require ad hoc corrections (especially for the slow wind in the vicinities of streamer/coronal hole boundaries) and empirical fits to in situ spacecraft data. A predictive law based solely on physical principles is still missing. Aims: We test whether the flux-tube expansion is the controlling factor of the wind speed at all phases of the cycle and at all latitudes (close to and far from streamer boundaries) using a very large sample of wind-carrying open magnetic flux-tubes. We furthermore search for additional physical parameters based on the geometry of the coronal magnetic field which have an influence on the terminal wind flow speed. Methods: We use numerical magneto-hydrodynamical simulations of the corona and wind coupled to a dynamo model to determine the properties of the coronal magnetic field and of the wind velocity (as a function of time and latitude) during a whole 11-yr activity cycle. These simulations provide a large statistical ensemble of open flux-tubes which we analyse conjointly in order to identify relations of dependence between the wind speed and geometrical parameters of the flux-tubes which are valid globally (for all latitudes and moments of the cycle). Results: Our study confirms that the terminal (asymptotic) speed of the solar wind depends very strongly on the geometry of the open magnetic flux-tubes through which it flows. The total flux-tube expansion is more clearly anti-correlated with the wind speed for fast rather than for slow wind flows, and effectively controls the

  15. Cell cycle arrest and apoptosis, two alternative mechanisms for PMKT2 killer activity.

    PubMed

    Santos, Antonio; Alonso, Alejandro; Belda, Ignacio; Marquina, Domingo

    2013-01-01

    Pichia membranifaciens CYC 1086 secretes a unique 30kDa killer toxin (PMKT2) that inhibits a variety of spoilage yeasts and fungi of agronomical interest. The cytocidal effect of PMKT2 on Saccharomyces cerevisiae cells was studied. Metabolic events associated with the loss of S. cerevisiae viability caused by PMKT2 were qualitatively identical to those reported for K28 killer toxin activity, but different to those reported for PMKT. At higher doses, none of the cellular events accounting for the action of PMKT, the killer toxin secreted by P. membranifaciens CYC 1106, was observed for PMKT2. Potassium leakage, sodium influx and the decrease of intracellular pH were not among the primary effects of PMKT2. We report here that this protein is unable to form ion-permeable channels in liposome membranes, suggesting that channel formation is not the mechanism of cytotoxic action of PMKT2. Nevertheless, flow cytometry studies have revealed a cell cycle arrest at an early S-phase with an immature bud and pre-replicated 1n DNA content. By testing the sensitivity of cells arrested at different stages in the cell cycle, we hoped to identify the execution point for lethality more precisely. Cells arrested at the G1-phase by α-factor or arrested at G2-phase by the spindle poison methyl benzimidazol-2-yl-carbamate (MBC) were protected against the toxin. Cells released from the arrest in both cases were killed by PMKT2 at a similar rate. Nevertheless, cells released from MBC-arrest were able to grow for a short time, and then viability dropped rapidly. These findings suggest that cells released from G2-phase are initially able to divide, but die in the presence of PMKT2 after initiating the S-phase in a new cycle, adopting a terminal phenotype within that cycle. By contrast, low doses of PMKT and PMKT2 were able to generate the same cellular response. The evidence presented here shows that treating yeast with low doses of PMKT2 leads to the typical membranous, cytoplasmic

  16. The activity of Krebs cycle enzymes in the visual analyzer of rats in the norm and under stress.

    PubMed

    Lutsenko, N S; Yakushev, V S

    1993-01-01

    Higher activity of the NAD-dependent dehydrogenases of the tricarboxylic acid cycle (TAC) is observed in the optic retina, and of FAD-dependent dehydrogenases in the occipital lobes of the brain, in the visual analyzer of intact rats. The influence of stress using Desiderato's method induces a compensatory increase in the activity of succinate dehydrogenase. Acute stress induces a change in the regulation of the activity of the TAC dehydrogenases, assessed on the basis of the reaction to functional load. The animals' remaining in the dark following stress promotes the restoration of the activity of the TAC cycle to the normal level. PMID:8413911

  17. Acute pancreatitis secondary to hyperlipidemia in an 11-year-old girl: A case report and review of literature

    PubMed Central

    Bălănescu, NR; Topor, L; Ulici, A; Djendov, FB

    2013-01-01

    We report the case of an 11-year-old female with acute pancreatitis, and review the literature highlighting the presenting symptoms and signs, laboratory tests, and investigational tools that helped in the establishment of a correct diagnosis. First, the patient presented to a regional hospital reporting abdominal pain, vomiting and liquid stool. She was admitted with the diagnosis of acute surgical abdomen and underwent surgery. Upon admission in our department, laboratory findings showed high values for total lipids = 2600 mg/dL and triglycerides 1200 mg/dL. Abdominal ultrasound revealed a pancreas with a small enlargement of the head (19 mm), and with a heterogeneous structure of the parenchyma. Abdominal computed tomography showed small left pleural collection and a high-dimensioned pancreas, particularly at the head, with heterogeneous structure, and peripancreatic collections. The patient was treated by fasting, gastric decompression by nasogastric tube, and intravenous antibiotherapy followed by antialgic and antispasticity treatment. Time of the patient’s first feeding was after the 7th day of hospitalization. The patient was discharged in a very good condition after 22 days of hospitalization. PMID:23599811

  18. Quinine sensitivity influences the acceptance of sea-buckthorn and grapefruit juices in 9- to 11-year-old children.

    PubMed

    Hartvig, Ditte; Hausner, Helene; Wendin, Karin; Bredie, Wender L P

    2014-03-01

    The acceptance of novel foods by children is related to a number of factors, and differences in taste sensitivity may form some specific challenges. High sensitivity might be a barrier to the acceptance of sour/bitter products by children. This study investigated the effect of sensitivity to bitter, sour, sweet, and salty tastes on the acceptance of Nordic juices in 9- to 11-year-old children. A total of 328 children were subjected to two taste sensitivity tests for quinine, citric acid, sucrose, and NaCl. Their acceptance of six juices (carrot, rosehip, sea-buckthorn, lingonberry, grapefruit, and aronia) was measured. Bitter sensitivity was found to be significantly correlated to the intake of the sweet sea-buckthorn and lingonberry juices; the most bitter-sensitive children exhibited the highest intake of these juices. The opposite relationship was found for bitter sensitivity and the intake of the bitter grapefruit juice. Sour, sweet, and salt sensitivities did not affect the intake of any of the juices. Liking scores were not affected by sensitivity. In conclusion, bitter sensitivity appears to influence food intake in children to a greater extent than sour, sweet, or salt sensitivity. Bitter-sensitive children exhibited a reduced intake of grapefruit juice and a higher intake of sucrose-sweetened juices. Thus, bitter sensitivity might be a challenge in the acceptance of certain bitter foods. PMID:24291404

  19. High-strength wastewater treatment in a pure oxygen thermophilic process: 11-year operation and monitoring of different plant configurations.

    PubMed

    Collivignarelli, M C; Bertanza, G; Sordi, M; Pedrazzani, R

    2015-01-01

    This research was carried out on a full-scale pure oxygen thermophilic plant, operated and monitored throughout a period of 11 years. The plant treats 60,000 t y⁻¹ (year 2013) of high-strength industrial wastewaters deriving mainly from pharmaceuticals and detergents production and landfill leachate. Three different plant configurations were consecutively adopted: (1) biological reactor + final clarifier and sludge recirculation (2002-2005); (2) biological reactor + ultrafiltration: membrane biological reactor (MBR) (2006); and (3) MBR + nanofiltration (since 2007). Progressive plant upgrading yielded a performance improvement chemical oxygen demand (COD) removal efficiency was enhanced by 17% and 12% after the first and second plant modification, respectively. Moreover, COD abatement efficiency exhibited a greater stability, notwithstanding high variability of the influent load. In addition, the following relevant outcomes appeared from the plant monitoring (present configuration): up to 96% removal of nitrate and nitrite, due to denitrification; low-specific biomass production (0.092 kgVSS kgCODremoved⁻¹), and biological treatability of residual COD under mesophilic conditions (BOD5/COD ratio = 0.25-0.50), thus showing the complementarity of the two biological processes. PMID:25746652

  20. Instrumented spondylodesis in degenerative spondylolisthesis with bioactive glass and autologous bone: a prospective 11-year follow-up.

    PubMed

    Frantzén, Janek; Rantakokko, Juho; Aro, Hannu T; Heinänen, Jyrki; Kajander, Sami; Gullichsen, Eero; Kotilainen, Esa; Lindfors, Nina C

    2011-10-01

    A prospective long-term follow-up study of bioactive glass (BAG)-S53P4 and autogenous bone (AB) used as bone graft substitutes for posterolateral spondylodesis in treatment of degenerative spondylolisthesis during 1996 to 1998 was conducted. The surgical procedure was a standardized instrumented posterolateral fusion that used USS/VAS. BAG was implanted on the left side of the fusion bed and AB on the right side. The operative outcome was evaluated on x-rays and computed tomography scans, and a clinical examination was also performed. Seventeen patients (12 women, 5 men) participated in the 11-year follow-up. The mean Oswestry Disability Index score at the follow-up was 21 (range 0 to 52), compared with 49 (range 32 to 64) at the preoperative time. A solid bony fusion was seen on computed tomography scans on the AB side in all patients and on the BAG side in 12 patients. The fusion rate of all fusion sites (n=41) for BAG as a bone substitute was 88% at the L4/5 level and 88% at the L5/S1 level. The use of BAG as a bone graft extender can be considered as a good alternative in spinal surgery in the future. PMID:21909036

  1. Nutritional status of adolescents: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    PubMed Central

    Araújo, Cora Luiza; Dumith, Samuel C.; Menezes, Ana M. B.; Hallal, Pedro C.; Vieira, Maria de Fátima A.; Madruga, Samanta W.; Victora, Cesar G.

    2013-01-01

    We evaluate the influence of demographic, socioeconomic, and maternal variables on the nutritional status of adolescents aged 11 years. We conducted a prospective cohort study including 4,452 adolescents born in Pelotas, Southern Brazil, in 1993, accounting for 87.5% of the original cohort. Nutritional status was evaluated based on World Health Organization criteria. Subjects were classified according to nutritional status into thin, normal, overweight and obese. Independent variables analyzed included skin color, socioeconomic status, maternal schooling, and maternal body mass index (BMI). Analyses were stratified by sex, and multivariable regression was performed using the multinomial logistic approach. Overall, 7% of adolescents were classified as thin, 11.6% as overweight, and 11.6% as obese. Among boys, thinness was inversely associated with maternal schooling and maternal BMI. Among girls, thinness was directly associated with maternal BMI. Overweight and obesity were directly associated with socioeconomic status and maternal BMI, the former showing the strongest association with nutritional status among adolescents. PMID:20963286

  2. Mental spatial transformations of objects and bodies: different developmental trajectories in children from 7 to 11 years of age.

    PubMed

    Crescentini, Cristiano; Fabbro, Franco; Urgesi, Cosimo

    2014-02-01

    Despite the large body of knowledge on adults suggesting that 2 basic types of mental spatial transformation--namely, object-based and egocentric perspective transformations--are dissociable and specialized for different situations, there is much less research investigating the developmental aspects of such spatial transformation systems. Here, an "own body transformation" paradigm and a letter transformation task were employed in a group of children ranging from 7 to 11 years of age to respectively investigate the development of egocentric perspective transformations and object-related transformations. A group of 30 young adults was also administered the 2 experimental tasks. Moreover, the Temperament and Character Inventory (Cloninger, Przybeck, Svrakic, & Wetzel, 1994) was also administered to children and adults with the goal of testing for possible influences of personality traits on imagined perspective transformation abilities. We found that egocentric perspective transformations develop later than object-based transformations--namely, from 8 rather than 7 years of age. We also found that high scores on temperament and character scales reflecting the acceptance of others (i.e., cooperativeness) were positively related to the ability to engage in imagined perspective transformations, especially when such ability first appears (i.e., at 8 years of age). These findings were held to support the view that the 2 mental spatial transformation systems are separated in that they follow 2 different developmental trajectories and are differentially influenced by personality traits in children. PMID:23815701

  3. [Expression of the emotions in the drawing of a man by the child from 5 to 11 years of age].

    PubMed

    Brechet, Claire; Picard, Delphine; Baldy, René

    2007-06-01

    This study examines the development of children's ability to express emotions in their human figure drawing. Sixty children of 5, 8, and 11 years were asked to draw "a man," and then a "sad", "happy," "angry" and "surprised" man. Expressivity of the drawings was assessed by means of two procedures: a limited choice and a free labelling procedure. Emotionally expressive drawings were then evaluated in terms of the number and the type of graphic cues that were used to express emotion. It was found that children are able to depict happiness and sadness at 8, anger and surprise at 11. With age, children use increasingly numerous and complex graphic cues for each emotion (i.e., facial expression, body position, and contextual cues). Graphic cues for facial expression (e.g., concave mouth, curved eyebrows, wide opened eyes) share strong similarities with specific "action units" described by Ekman and Friesen (1978) in their Facial Action Coding System. Children's ability to depict emotion in their human figure drawing is discussed in relation to perceptual, conceptual, and graphic abilities. PMID:17665754

  4. Diagnosis and Treatment of Odontogenic Cutaneous Sinus Tracts in an 11-Year-Old Boy: A Case Report.

    PubMed

    Chen, Ke; Liang, Yun; Xiong, Huacui

    2016-05-01

    Odontogenic cutaneous sinus tracts (OCSTs) are generally primarily misdiagnosed and inappropriately treated by virtue of their rarity and the absence of dental symptoms. Accurate diagnosis and treatment and the elimination of the source of infection can reduce the incidence of complications and relieve the pain of the patient.In this case report, we present the case of an 11-year-old patient with an apparent abscess but an unobvious draining sinus tract in his left cheek. Intraorally, a glass-ionomer-cement filling on the occlusal surface of the left mandibular first molar (tooth 36) was noted. Radiographic examination revealed a radiopaque mass inside the crown and pulp chamber and an irregular, radiolucent periapical lesion surrounding the distal root apex. He was diagnosed with an OCTS secondary to a periapical abscess of tooth 36. Precise root canal therapy (RCT) and chronic granuloma debridement was performed; 6 months later, the abscess and sinus had healed completely, and the periapical lesion had resolved.Odontogenic cutaneous sinus tracts are uncommon in the clinic. This case report reminds us of the significance of OCSTs and provides some implications for their diagnosis and treatment. PMID:27196471

  5. Listeria monocytogenes Isolates from Invasive Infections: Variation of Sero- and Genotypes during an 11-Year Period in Finland

    PubMed Central

    Lukinmaa, Susanna; Miettinen, Maria; Nakari, Ulla-Maija; Korkeala, Hannu; Siitonen, Anja

    2003-01-01

    Listeria monocytogenes strains that were isolated from 314 human listeriosis cases in Finland during an 11-year period were analyzed by O:H serotyping and pulsed-field gel electrophoresis (PFGE). Serotyping divided the isolates into five serotypes, the most common being 1/2a (53%) and 4b (27%). During the study period, the number of cases caused by serotype 1/2a increased from 22% in 1990 to 67% in 2001, and those caused by serotype 4b decreased from 61 to 27%, respectively. PFGE with restriction enzyme AscI divided the strains into 81 PFGE genotypes; among strains of serotypes 1/2a and 4b, 49 and 18 PFGE types were seen, respectively. PFGE type 1 (serotype 1/2a) was the most prevalent single type (37 strains). Together with six other, closely related PFGE types, PFGE type 1 formed a group of 71 strains, representing 23% of all 314 strains. Strains of PFGE type 1 have also been isolated from cold smoked fish, suggesting a source of human infections caused by this type. Moreover, PFGE type 24 (serotype 1/2c) was significantly associated with gender: 5% of 180 male subjects but none of 132 female subjects (P = 0.012). An electronic database library was created from the PFGE profiles to make possible the prompt detection of new emerging profiles and the tracing of potential infection clusters in the future. PMID:12682162

  6. Oral hygiene habits of 11-year-old schoolchildren in 22 European countries and Canada in 1993/1994.

    PubMed

    Kuusela, S; Honkala, E; Kannas, L; Tynjälä, J; Wold, B

    1997-09-01

    This study is part of the Cross-National Survey on Health Behaviour in School-aged Children--a WHO Collaborative Study, which started in 1982. The aim of the study was to describe the oral hygiene habits (toothbrushing and flossing) of 11-year-old schoolchildren in 22 European countries (Austria, Belgium, the Czech Republic, Denmark, Estonia, FInland, France, Germany, Greenland, Hungary, Israel, Latvia, Lithuania, Northern Ireland, Norway, Poland, Russia, Scotland, the Slovak Republic, Spain, Sweden, and Wales) and Canada. The data were collected from standardized anonymous questionnaires in school classrooms during the 1993-1994 school year. At least 1300 school children, representing the whole country, participated in the study in each country. Oral hygiene habits were analyzed according to gender, age, country, school performance, and family economy. The children brushed most favorably in Sweden, Denmark, German, Austria, and Norway (83-73% brushed twice a day). More-than-once-a-day toothbrushing was especially uncommon (from 26 to 33%) among boys in Finland, Lithuania, Russia, Estonia, and Latvia. Toothbrushing frequency differed significantly according to school performance in Canada, the Czech Republic, Scotland, Poland, Northern Ireland, and Wales and between different socio-economic groups in Northern Ireland, Wales, the Czech Republic, Scotland, Poland, and Russia. Use of dental floss was rare. In general, flossing was less frequent among boys than among girls. Daily flossing was most common among Canadian adolescents (25%). In conclusion, there are considerable differences in toothbrushing frequency among children in European countries. PMID:9294495

  7. Dental status and orthodontic treatment needs of an 11-year-old female resident of Athens, 430 BC.

    PubMed

    Papagrigorakis, Manolis J; Synodinos, Philippos N; Baziotopoulou-Valavani, Effie

    2008-01-01

    This report presents the skeletal and dental features of "Myrtis", an 11-year-old female resident of ancient Athens back in 430 BC. Her skeleton was unearthed in an archaeological excavation of a mass burial pit located in the outskirts of Kerameikos' ancient cemetery of Athens. "Myrtis" is believed to have been one of the numerous hapless victims of the Plague of Athens. Her skull was found in relatively intact condition bearing her complete dentition corresponding to the mixed dentition stage. A complete dental and orthodontic diagnosis of Myrtis was conducted based on clinical examination, study of panoramic radiographs, and lateral cephalometric analysis of her skull. No significant dental pathology was reported pertaining to deciduous or permanent teeth of "Myrtis". A Class II skeletal and dental malocclusion was observed. The ectopic labial eruption of the maxillary canines mesially to their retained deciduous predecessors, the ectopic distally directed eruption of a lower first premolar, and a unilaterally missing lower third molar were among the most interesting dental findings reported. PMID:18193954

  8. Active sulfur cycling by diverse mesophilic and thermophilic microorganisms in terrestrial mud volcanoes of Azerbaijan.

    PubMed

    Green-Saxena, A; Feyzullayev, A; Hubert, C R J; Kallmeyer, J; Krueger, M; Sauer, P; Schulz, H-M; Orphan, V J

    2012-12-01

    Terrestrial mud volcanoes (TMVs) represent geochemically diverse habitats with varying sulfur sources and yet sulfur cycling in these environments remains largely unexplored. Here we characterized the sulfur-metabolizing microorganisms and activity in four TMVs in Azerbaijan. A combination of geochemical analyses, biological rate measurements and molecular diversity surveys (targeting metabolic genes aprA and dsrA and SSU ribosomal RNA) supported the presence of active sulfur-oxidizing and sulfate-reducing guilds in all four TMVs across a range of physiochemical conditions, with diversity of these guilds being unique to each TMV. The TMVs varied in potential sulfate reduction rates (SRR) by up to four orders of magnitude with highest SRR observed in sediments where in situ sulfate concentrations were highest. Maximum temperatures at which SRR were measured was 60°C in two TMVs. Corresponding with these trends in SRR, members of the potentially thermophilic, spore-forming, Desulfotomaculum were detected in these TMVs by targeted 16S rRNA analysis. Additional sulfate-reducing bacterial lineages included members of the Desulfobacteraceae and Desulfobulbaceae detected by aprA and dsrA analyses and likely contributing to the mesophilic SRR measured. Phylotypes affiliated with sulfide-oxidizing Gamma- and Betaproteobacteria were abundant in aprA libraries from low sulfate TMVs, while the highest sulfate TMV harboured 16S rRNA phylotypes associated with sulfur-oxidizing Epsilonproteobacteria. Altogether, the biogeochemical and microbiological data indicate these unique terrestrial habitats support diverse active sulfur-cycling microorganisms reflecting the in situ geochemical environment. PMID:23116231

  9. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

    PubMed

    Nuber, Susanne; Zabel, Ulrike; Lorenz, Kristina; Nuber, Andreas; Milligan, Graeme; Tobin, Andrew B; Lohse, Martin J; Hoffmann, Carsten

    2016-03-31

    (β-)Arrestins are important regulators of G-protein-coupled receptors (GPCRs). They bind to active, phosphorylated GPCRs and thereby shut off 'classical' signalling to G proteins, trigger internalization of GPCRs via interaction with the clathrin machinery and mediate signalling via 'non-classical' pathways. In addition to two visual arrestins that bind to rod and cone photoreceptors (termed arrestin1 and arrestin4), there are only two (non-visual) β-arrestin proteins (β-arrestin1 and β-arrestin2, also termed arrestin2 and arrestin3), which regulate hundreds of different (non-visual) GPCRs. Binding of these proteins to GPCRs usually requires the active form of the receptors plus their phosphorylation by G-protein-coupled receptor kinases (GRKs). The binding of receptors or their carboxy terminus as well as certain truncations induce active conformations of (β-)arrestins that have recently been solved by X-ray crystallography. Here we investigate both the interaction of β-arrestin with GPCRs, and the β-arrestin conformational changes in real time and in living human cells, using a series of fluorescence resonance energy transfer (FRET)-based β-arrestin2 biosensors. We observe receptor-specific patterns of conformational changes in β-arrestin2 that occur rapidly after the receptor-β-arrestin2 interaction. After agonist removal, these changes persist for longer than the direct receptor interaction. Our data indicate a rapid, receptor-type-specific, two-step binding and activation process between GPCRs and β-arrestins. They further indicate that β-arrestins remain active after dissociation from receptors, allowing them to remain at the cell surface and presumably signal independently. Thus, GPCRs trigger a rapid, receptor-specific activation/deactivation cycle of β-arrestins, which permits their active signalling. PMID:27007855

  10. Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle.

    PubMed

    Kim, J H; Park, J H; Eisenhut, M; Yu, J W; Shin, J I

    2016-08-01

    Inflammasomes are caspase-1-activating molecular platforms that produce active interleukin (IL)-1β and are implicated in various central nervous system (CNS) diseases. These multi-protein complexes can be activated by exposure of cells to low osmolality. The inflammasome nucleotide-binding and oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) is hereby the main sensor of cellular osmolality. IL-1β was found to stimulate the secretion of antidiuretic hormone (ADH) from the posterior pituitary gland either by action of prostaglandins or indirectly by causing the release of IL-6. Based on these findings, we hypothesize that the hyponatremia caused by a wide range of CNS diseases is able to induce significant cell swelling with induction of a hyposmotic intracellular environment, which activates the NLRP3 inflammasome, causing the release of IL-1β and induced by IL-1β, IL-6, which increases the production of ADH that leads to more profound hyponatremia. Supportive evidence for this hypothesis is the finding that IL-1 injection can induce ADH release and hyposmotic effect of ADH induced hyponatremia can, via the mechanical effect of cell swelling, activate transient receptor potential channels, which via transforming growth factor β-activated kinase 1 activate NLRP3. Implications of this hypothesis, if confirmed, would include that hyponatremia can be exacerbated through this vicious cycle but also that the inflammasomes are key mediators of this process. Confirmation of this hypothesis would have implications for prevention and clinical management of changes in patients sodium levels related to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with interventions targeting inflammatory mediator production and function of inflammasomes with the potential of prevention of permanent brain damage in a wide range of CNS diseases. PMID:27372869

  11. Impact of Mitochondria-Mediated Apoptosis in U251 Cell Cycle Arrest in G1 Stage and Caspase Activation

    PubMed Central

    Zhang, Lei; Liang, Peng; Zhang, Rui

    2015-01-01

    Background Most mitochondria-mediated apoptosis has some relevance to the cell cycle, but there is still a lack of investigations about U251 cell cycle in human brain glioma cells. In this study, we aimed to clarify the correlation of mitochondria-mediated apoptosis with the U251 cell cycle and its influence on apoptosis, through observing the impact of mitochondria-mediated apoptosis in U251cell specificity cycle arrest and Caspase activation. Material/Methods AnnexinV/PI and API were used to label the brain glioma cells for flow cytometry analysis of U251 cell apoptosis and cell cycle. RT-PCR and Western blot were performed to detect Caspase-3 and Caspase-9 activation. Results Peripheral blood in stationary phase is not sensitive to apoptosis induction, but U251 cells have obvious apoptosis. Mitochondria-mediated apoptosis mainly occurs in the G1 phase of the cell cycle. Caspase-3 and Caspase-9 mRNAs and proteins expression increased significantly after the cells were treated by mitochondrial apoptosis-related gene Bax induction. Conclusions Mitochondria-mediated apoptosis is related to the U251 cell cycle with specific G1 stage arrest. Caspase activation occurs in the process of cell apoptosis. PMID:26594875

  12. Effects of cycle duration of an external electrostatic field on anammox biomass activity.

    PubMed

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m(3)/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application. PMID:26794647

  13. BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability

    PubMed Central

    Yata, Keiko; Bleuyard, Jean-Yves; Nakato, Ryuichiro; Ralf, Christine; Katou, Yuki; Schwab, Rebekka A.; Niedzwiedz, Wojciech; Shirahige, Katsuhiko; Esashi, Fumiko

    2014-01-01

    Summary Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we show that the breast cancer susceptibility protein BRCA2, a key Rad51 binding partner, coordinates the activity of the central cell-cycle drivers CDKs and Plk1 to promote Rad51-mediated genome stability control. The soluble nuclear fraction of BRCA2 binds Plk1 directly in a cell-cycle- and CDK-dependent manner and acts as a molecular platform to facilitate Plk1-mediated Rad51 phosphorylation. This phosphorylation is important for enhancing the association of Rad51 with stressed replication forks, which in turn protects the genomic integrity of proliferating human cells. This study reveals an elaborate but highly organized molecular interplay between Rad51 regulators and has significant implications for understanding tumorigenesis and therapeutic resistance in patients with BRCA2 deficiency. PMID:24835992

  14. Research and Technology Activities Supporting Closed-Brayton-Cycle Power Conversion System Development

    NASA Technical Reports Server (NTRS)

    Barrett, Michael J.

    2004-01-01

    The elements of Brayton technology development emphasize power conversion system risk mitigation. Risk mitigation is achieved by demonstrating system integration feasibility, subsystem/component life capability (particularly in the context of material creep) and overall spacecraft mass reduction. Closed-Brayton-cycle (CBC) power conversion technology is viewed as relatively mature. At the 2-kWe power level, a CBC conversion system Technology Readiness Level (TRL) of six (6) was achieved during the Solar Dynamic Ground Test Demonstration (SD-GTD) in 1998. A TRL 5 was demonstrated for 10 kWe-class CBC components during the development of the Brayton Rotating Unit (BRU) from 1968 to 1976. Components currently in terrestrial (open cycle) Brayton machines represent TRL 4 for similar uses in 100 kWe-class CBC space systems. Because of the baseline component and subsystem technology maturity, much of the Brayton technology task is focused on issues related to systems integration. A brief description of ongoing technology activities is given.

  15. Effects of cycle duration of an external electrostatic field on anammox biomass activity

    NASA Astrophysics Data System (ADS)

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m3/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application.

  16. Earthquake cycle associated with active strike slip faults in central Panamá

    NASA Astrophysics Data System (ADS)

    Rick, Bennett; Spinler, Joshua C.; Compton, Kathleen; Rockwell, Thomas K.; Gath, Eldon

    2013-04-01

    The rigidity of the Panamá Isthmus is currently under debate, with important implications for seismic hazards to the Panamá Canal and Panamá City. Whereas Panamá has traditionally been described as a non-deforming microplate caught between a number of larger tectonic plates, new paleoseismic data collected at a limited number of trench sites in association with the ongoing expansion of the Panamá Canal may challenge the validity of the rigid microplate hypothesis. Crustal velocities from a new, ~100 km aperture, 5-station continuous GPS network constructed across the Rio Gatún, Limón, and Pedro Miguel fault zones confirm that these fault zones are active, forming a system of faults that traverse central Panamá in close proximity to the Panamá Canal and Panamá City. However, the slip rates inferred from these new geodetic data are lower than the geologic rates when using an elastic halfspace model. Differences among previous geodetic investigations, which concluded that Panamá is rigid, and the geological slip rate estimates are explained by earthquake cycle effects associated with long recurrence intervals relative to lower crust and upper mantle Maxwell relaxation times. Late in the earthquake cycle the geodetic strain field is broadly distributed, giving the false appearance of low seismic hazards.

  17. Effects of cycle duration of an external electrostatic field on anammox biomass activity

    PubMed Central

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m3/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application. PMID:26794647

  18. Long term determinants of functional decline of mobility: an 11-year follow-up of 5464 adults of late middle aged and elderly.

    PubMed

    Lêng, Chhian Hūi; Wang, Jung-Der

    2013-01-01

    This confirmatory study aims at investigating the long term determinants of mobility limitation among late middle aged and elderly in a physically less active population. Five thousand four hundred and sixty-four participants aged 50-97 in 1996 enrolled the Taiwan Longitudinal Study on Aging (TLSA) for four waves of interview during 11 years. Social and health-related determinants were collected in each interview. Mobility limitation was enquired level of difficulty in eight movement tasks, including lifting 11kg weight, squatting, running 20-30m, standing for 15min, walking 200-300m, climbing up two to three floors, raising arms up and grasping with fingers. According to the mixed models with repeated measurements, more frequent gardening and longer time for each exercise predicted subsequent better mobility function in Taiwanese elderly while controlling demographics and current comorbidities. The protective effect of gardening was robust in all models. Frequent alcohol consumption was harmful to future mobility function, but less as harmful when participants aged. Besides, the depression-related somatic complaints were predictive to future mobility limitation among those without limitation at baseline. It shall be worthy to explore the dosage as well as the mechanism of these protective factors, especially the most significant but the least explored factor, gardening. Additionally, efforts should be made to understand the relationship between depression-related somatic complaints and mobility decline and so as the relevant interventions. PMID:23608344

  19. Predictions of the onset of mini ice age in the 25th solar cycle

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv

    2016-07-01

    Predictions of the ir-regularty in the 11 year heartbeat of the sun due to asyncronous of the two layered dynamo effect would result in mini ice age as in the Maunder minimum.The onset of this event is expected in the begining of 25th solar cycle and would go to its maximum in the 26th solar cycle.The minimum temperature is expected in 2028 due to the fall of solar activity by 60 % termed as solar hibernation.The predictions are based on the observations obtained by the Royal Greenwich observatory since 1874. Keywords: Dynamo effect,munder minimum,Solar hybernation

  20. THE REGENERATIVE CYCLE OF MOTONEURONS, WITH SPECIAL REFERENCE TO PHOSPHATASE ACTIVITY

    PubMed Central

    Bodian, David; Mellors, Robert C.

    1945-01-01

    1. The regenerative cycle of motoneurons after axon amputation is described, and an attempt made to correlate morphological and chemical events in cell bodies with the growth requirements of regenerating axons. 2. The "normal" pattern of Nissl material in the cell is considered to be the resultant of a steady state in cytoplasmic nucleoprotein. Chromatol is then interpreted as a shift of the balance of nucleoprotein turnover in fa of degradation. The rapid early depletion of Nissl substance in chromatolysis is ascribed to the increased growth requirements created by the active early sprouting of the regenerating axon. Acid phosphatase activity begins to increase above normal levels during this period in the region of nucleopro degradation. 3. The recovery period of chromatolysis due to axon section coincide in time with the phase of gradual lengthening of the regenerating axon, and is thought to represent a gradual restoration of the balance of nucleoprotein degradation and synthesis. During this period acid phosphatase activity is at its height in the region of transformation of Nissl substance, later declines to normal levels when the original pattern of Nissl bodie is restored. 4. The transformation of cytoplasmic nucleoprotein which occurs in chromatolysis after axon section, with the probable liberation (46), and depletion (44), of nucleotides, associated with acid phosphatase activity, suggests the hypothesis that liberated nucleotides or nucleotide compounds may pass down the axon in which they take part in enzymatic activity associated with growth and organization of the newly formed axon. This type of activity would not be incompatible with the ideas previously expressed (30, 81) of a continual function of Nissl substance in maintaining the integrity of the large volume of cytoplasm represented by the axon, as well perhaps as the associated myelin sheath. PMID:19871470

  1. OBSERVATIONAL ASPECTS OF THE THREE-DIMENSIONAL CORONAL STRUCTURE OVER A SOLAR ACTIVITY CYCLE

    SciTech Connect

    Morgan, Huw; Habbal, Shadia Rifai

    2010-02-10

    Solar rotational tomography is applied to almost eleven years of Large Angle Spectrometric Coronagraph C2/Solar and Heliospheric Observatory data, revealing for the first time the behavior of the large-scale coronal density structures, also known as streamers, over almost a full solar activity cycle. This study gives an overview of the main results of this project. (1) Streamers are most often shaped as extended, narrow plasma sheets. The sheets can be extremely narrow at times (<=0.14 x 10{sup 6} km at 4 R{sub sun}). This is over twice their heliocentric angular thickness at 1 AU. (2) At most times outside the height of solar maximum, there are two separate stable large helmet streamer belts extending from mid-latitudes (in both north and south). At solar minimum, the streamers converge and join near the equator, giving the impression of a single large helmet streamer. Outside of solar minimum, the two streamers do not join, forming separate high-density sheets in the extended corona (one in the north, another in the south). At solar maximum, streamers rise radially from their source regions, while during the ascending and descending activity phases, streamers are skewed toward the equator. (3) For most of the activity cycle, streamers share the same latitudinal extent as filaments on the disk, showing that large-scale stable streamers are closely linked to the same large-scale photospheric magnetic configuration, which give rise to large filaments. (4) The poleward footpoints of the streamers are often above crown polar filaments and the equatorial footpoints are above filaments or active regions (or above the photospheric neutral lines which underlie these structures). The high-density structures arising from the equatorial active regions either rise and form the equatorial footpoints of mid-latitude quiescent streamers, or form unstable streamers at the equator, not connected to the quiescent streamer structure at higher latitude (so there are often three

  2. 14C Activity and Global Carbon Cycle Changes over the Past 50,000 Years

    NASA Astrophysics Data System (ADS)

    Hughen, K.; Lehman, S.; Southon, J.; Overpeck, J.; Marchal, O.; Herring, C.; Turnbull, J.

    2004-01-01

    A series of 14C measurements in Ocean Drilling Program cores from the tropical Cariaco Basin, which have been correlated to the annual-layer counted chronology for the Greenland Ice Sheet Project 2 (GISP2) ice core, provides a high-resolution calibration of the radiocarbon time scale back to 50,000 years before the present. Independent radiometric dating of events correlated to GISP2 suggests that the calibration is accurate. Reconstructed 14C activities varied substantially during the last glacial period, including sharp peaks synchronous with the Laschamp and Mono Lake geomagnetic field intensity minimal and cosmogenic nuclide peaks in ice cores and marine sediments. Simulations with a geochemical box model suggest that much of the variability can be explained by geomagnetically modulated changes in 14C production rate together with plausible changes in deep-ocean ventilation and the global carbon cycle during glaciation.

  3. Solar neutrinos, solar flares, solar activity cycle and the proton decay

    NASA Technical Reports Server (NTRS)

    Raychaudhuri, P.

    1985-01-01

    It is shown that there may be a correlation between the galactic cosmic rays and the solar neutrino data, but it appears that the neutrino flux which may be generated during the large solar cosmic ray events cannot in any way effect the solar neutrino data in Davis experiment. Only initial stage of mixing between the solar core and solar outer layers after the sunspot maximum in the solar activity cycle can explain the higher (run number 27 and 71) of solar neutrino data in Davis experiment. But solar flare induced atmospheric neutrino flux may have effect in the nucleon decay detector on the underground. The neutrino flux from solar cosmic rays may be a useful guide to understand the background of nucleon decay, magnetic monopole search, and the detection of neutrino flux in sea water experiment.

  4. RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

    PubMed Central

    Ogawa, Daisuke; Abe, Kiyomi; Miyao, Akio; Kojima, Mikiko; Sakakibara, Hitoshi; Mizutani, Megumi; Morita, Haruka; Toda, Yosuke; Hobo, Tokunori; Sato, Yutaka; Hattori, Tsukaho; Hirochika, Hirohiko; Takeda, Shin

    2011-01-01

    Plant growth and development are sustained by continuous cell division in the meristems, which is perturbed by various environmental stresses. For the maintenance of meristematic functions, it is essential that cell division be coordinated with cell differentiation. However, it is unknown how the proliferative activities of the meristems and the coordination between cell division and differentiation are maintained under stressful conditions. Here we show that a rice protein, RSS1, whose stability is controlled by cell cycle phases, contributes to the vigour of meristematic cells and viability under salinity conditions. These effects of RSS1 are exerted by regulating the G1–S transition, possibly through an interaction of RSS1 with protein phosphatase 1, and are mediated by the phytohormone, cytokinin. RSS1 is conserved widely in plant lineages, except eudicots, suggesting that RSS1-dependent mechanisms might have been adopted in specific lineages during the evolutionary radiation of angiosperms. PMID:21505434

  5. Dependence of Stellar Magnetic Activity Cycles on Rotational Period in a Nonlinear Solar-type Dynamo

    NASA Astrophysics Data System (ADS)

    Pipin, V. V.; Kosovichev, A. G.

    2016-06-01

    We study the turbulent generation of large-scale magnetic fields using nonlinear dynamo models for solar-type stars in the range of rotational periods from 14 to 30 days. Our models take into account nonlinear effects of dynamical quenching of magnetic helicity, and escape of magnetic field from the dynamo region due to magnetic buoyancy. The results show that the observed correlation between the period of rotation and the duration of activity cycles can be explained in the framework of a distributed dynamo model with a dynamical magnetic feedback acting on the turbulent generation from either magnetic buoyancy or magnetic helicity. We discuss implications of our findings for the understanding of dynamo processes operating in solar-like stars.

  6. THE ACOUSTIC CUTOFF FREQUENCY OF THE SUN AND THE SOLAR MAGNETIC ACTIVITY CYCLE

    SciTech Connect

    Jimenez, A.; Palle, P. L.; Garcia, R. A.

    2011-12-20

    The acoustic cutoff frequency-the highest frequency for acoustic solar eigenmodes-is an important parameter of the solar atmosphere as it determines the upper boundary of the p-mode resonant cavities. At frequencies beyond this value, acoustic disturbances are no longer trapped but are traveling waves. Interference among them gives rise to higher-frequency peaks-the pseudomodes-in the solar acoustic spectrum. The pseudomodes are shifted slightly in frequency with respect to p-modes, making possible the use of pseudomodes to determine the acoustic cutoff frequency. Using data from the GOLF and VIRGO instruments on board the Solar and Heliospheric Observatory spacecraft, we calculate the acoustic cutoff frequency using the coherence function between both the velocity and intensity sets of data. By using data gathered by these instruments during the entire lifetime of the mission (1996 until the present), a variation in the acoustic cutoff frequency with the solar magnetic activity cycle is found.

  7. Activation of the methylation cycle in cells reprogrammed into a stem cell-like state

    PubMed Central

    Bosch-Barrera, Joaquim; Alarcón, Tomás; Joven, Jorge; Menendez, Javier A.

    2015-01-01

    Generation of induced pluripotent stem (iPS) cells and cancer biogenesis share similar metabolic switches. Most studies have focused on how the establishment of a cancer-like glycolytic phenotype is necessary for the optimal routing of somatic cells for achieving stemness. However, relatively little effort has been dedicated towards elucidating how one-carbon (1C) metabolism is retuned during acquisition of stem cell identity. Here we used ultra-high pressure liquid chromatography coupled to an electrospray ionization source and a triple-quadrupole mass spectrometer [UHPLC-ESI-QqQ-MS/MS] to quantitatively examine the methionine/folate bi-cyclic 1C metabolome during nuclear reprogramming of somatic cells into iPS cells. iPS cells optimize the synthesis of the universal methyl donor S-adenosylmethionine (SAM), apparently augment the ability of the redox balance regulator NADPH in SAM biosynthesis, and greatly increase their methylation potential by triggering a high SAM:S-adenosylhomocysteine (SAH) ratio. Activation of the methylation cycle in iPS cells efficiently prevents the elevation of homocysteine (Hcy), which could alter global DNA methylation and induce mitochondrial toxicity, oxidative stress and inflammation. In this regard, the methyl donor choline is also strikingly accumulated in iPS cells, suggesting perhaps an overactive intersection of the de novo synthesis of choline with the methionine-Hcy cycle. Activation of methylogenesis and maintenance of an optimal SAM:Hcy ratio might represent an essential function of 1C metabolism to provide a labile pool of methyl groups and NADPH-dependent redox products required for successfully establishing and maintaining an embryonic-like DNA methylation imprint in stem cell states. PMID:26909364

  8. Metaproteogenomics reveals the soil microbial communities active in nutrient cycling processes under different tree species

    NASA Astrophysics Data System (ADS)

    Keiblinger, Katharina Maria; Masse, Jacynthe; Zühlke, Daniela; Riedel, Katharina; Zechmeister-Boltenstern, Sophie; Prescott, Cindy E.; Grayston, Sue

    2016-04-01

    Tree species exert strong effects on microbial communities in litter and soil and may alter rates of soil processes fundamental to nutrient cycling and carbon fluxes (Prescott and Grayston 2013). However, the influence of tree species on decomposition processes are still contradictory and poorly understood. An understanding of the mechanisms underlying plant influences on soil processes is important for our ability to predict ecosystem response to altered global/environmental conditions. In order to link microbial community structure and function to forest-floor nutrient cycling processes, we sampled forest floors under western redcedar (Thuja plicata), Douglas-fir (Pseudotsuga menziesii) and Sitka spruce (Picea sitchensis) grown in nutrient-poor sites in common garden experiments on Vancouver island (Canada). We measured forest-floor total N, total C, initial NH4+ and NO3‑ concentrations, DOC, Cmic and Nmic. Gross rates of ammonification and NH4+ consumption were measured using the 15N pool-dilution method. Organic carbon quality was assessed through FTIR analyses. Microbial community structure was analysed by a metaproteogenomic approach using 16S and ITS amplification and sequencing with MiSeq platform. Proteins were extracted and peptides characterized via LC-MS/MS on a Velos Orbitrap to assess the active microbial community. Different microbial communities were active under the three tree species and variation in process rates were observed and will be discussed. This research provides new insights on microbial processes during organic matter decomposition. The metaproteogenomic approach enables us to investigate these changes with respect to possible effects on soil C-storage at even finer taxonomic resolution.

  9. Natural Compounds' Activity against Cancer Stem-Like or Fast-Cycling Melanoma Cells

    PubMed Central

    Majchrzak, Kinga; Hartman, Mariusz; Czyz, Malgorzata

    2014-01-01

    Background Accumulating evidence supports the concept that melanoma is highly heterogeneous and sustained by a small subpopulation of melanoma stem-like cells. Those cells are considered as responsible for tumor resistance to therapies. Moreover, melanoma cells are characterized by their high phenotypic plasticity. Consequently, both melanoma stem-like cells and their more differentiated progeny must be eradicated to achieve durable cure. By reevaluating compounds in heterogeneous melanoma populations, it might be possible to select compounds with activity not only against fast-cycling cells but also against cancer stem-like cells. Natural compounds were the focus of the present study. Methods We analyzed 120 compounds from The Natural Products Set II to identify compounds active against melanoma populations grown in an anchorage-independent manner and enriched with cells exerting self-renewing capacity. Cell viability, cell cycle arrest, apoptosis, gene expression, clonogenic survival and label-retention were analyzed. Findings Several compounds efficiently eradicated cells with clonogenic capacity and nanaomycin A, streptonigrin and toyocamycin were effective at 0.1 µM. Other anti-clonogenic but not highly cytotoxic compounds such as bryostatin 1, siomycin A, illudin M, michellamine B and pentoxifylline markedly reduced the frequency of ABCB5 (ATP-binding cassette, sub-family B, member 5)-positive cells. On the contrary, treatment with maytansine and colchicine selected for cells expressing this transporter. Maytansine, streptonigrin, toyocamycin and colchicine, even if highly cytotoxic, left a small subpopulation of slow-dividing cells unaffected. Compounds selected in the present study differentially altered the expression of melanocyte/melanoma specific microphthalmia-associated transcription factor (MITF) and proto-oncogene c-MYC. Conclusion Selected anti-clonogenic compounds might be further investigated as potential adjuvants targeting melanoma stem

  10. A mechanistic soil biogeochemistry model with explicit representation of microbial and macrofaunal activities and nutrient cycles

    NASA Astrophysics Data System (ADS)

    Fatichi, Simone; Manzoni, Stefano; Or, Dani; Paschalis, Athanasios

    2016-04-01

    The potential of a given ecosystem to store and release carbon is inherently linked to soil biogeochemical processes. These processes are deeply connected to the water, energy, and vegetation dynamics above and belowground. Recently, it has been advocated that a mechanistic representation of soil biogeochemistry require: (i) partitioning of soil organic carbon (SOC) pools according to their functional role; (ii) an explicit representation of microbial dynamics; (iii) coupling of carbon and nutrient cycles. While some of these components have been introduced in specialized models, they have been rarely implemented in terrestrial biosphere models and tested in real cases. In this study, we combine a new soil biogeochemistry model with an existing model of land-surface hydrology and vegetation dynamics (T&C). Specifically the soil biogeochemistry component explicitly separates different litter pools and distinguishes SOC in particulate, dissolved and mineral associated fractions. Extracellular enzymes and microbial pools are explicitly represented differentiating the functional roles of bacteria, saprotrophic and mycorrhizal fungi. Microbial activity depends on temperature, soil moisture and litter or SOC stoichiometry. The activity of macrofauna is also modeled. Nutrient dynamics include the cycles of nitrogen, phosphorous and potassium. The model accounts for feedbacks between nutrient limitations and plant growth as well as for plant stoichiometric flexibility. In turn, litter input is a function of the simulated vegetation dynamics. Root exudation and export to mycorrhiza are computed based on a nutrient uptake cost function. The combined model is tested to reproduce respiration dynamics and nitrogen cycle in few sites where data were available to test plausibility of results across a range of different metrics. For instance in a Swiss grassland ecosystem, fine root, bacteria, fungal and macrofaunal respiration account for 40%, 23%, 33% and 4% of total belowground

  11. Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

    PubMed Central

    McCormack, Ryan M; Lyapichev, Kirill; Olsson, Melissa L; Podack, Eckhard R; Munson, George P

    2015-01-01

    Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapid redistribution of Perforin-2 and is essential for its bactericidal activity. Enteric pathogens such as Yersinia pseudotuberculosis and enteropathogenic Escherichia coli disarm host cells by injecting cell cycle inhibiting factors (Cifs) into mammalian cells to deamidate the ubiquitin-like protein NEDD8. Because CRL activity is dependent upon NEDD8, Cif blocks ubiquitin dependent trafficking of Perforin-2 and thus, its bactericidal activity. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria. DOI: http://dx.doi.org/10.7554/eLife.06505.001 PMID:26418746

  12. Suppression of cell cycle progression by a fungal lectin: activation of cyclin-dependent kinase inhibitors.

    PubMed

    Liua, W; Ho, J C; Ng, T

    2001-01-01

    The antiproliferative activity of a fungal lectin (VVL) isolated from the mushroom, Volvariella volvacea, was studied using a battery of cultured tumor cell lines. It was revealed that [(3)H]thymidine incorporation into the cell lines was markedly reduced at 0.32 microM VVL. When S180 mouse sarcoma cells were incubated for 48 hr with doses of VVL ranging from 0.32 to 0.8 microM, prominent blebs on the cell surface and large vacuoles in the cytoplasm, but not apoptotic bodies, were observed under a fluorescence microscopy. VVL did not exert ribosome-inactivating activity or induce any changes in the expression of cyclins A, D1, and E. However, it did activate the expression of cyclin kinase inhibitors, namely p21, p27, p53, and Rb, in a dose-dependent manner. Flow cytometric analysis demonstrated an accumulation of cells in the G2/M phase in a time- and dose-dependent manner, indicating that VVL arrested cell proliferation by blocking cell cycle progression in the G2/M phase. PMID:11137706

  13. Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.

    PubMed

    Deneke, Victoria E; Melbinger, Anna; Vergassola, Massimo; Di Talia, Stefano

    2016-08-22

    Embryos of most metazoans undergo rapid and synchronous cell cycles following fertilization. While diffusion is too slow for synchronization of mitosis across large spatial scales, waves of Cdk1 activity represent a possible process of synchronization. However, the mechanisms regulating Cdk1 waves during embryonic development remain poorly understood. Using biosensors of Cdk1 and Chk1 activities, we dissect the regulation of Cdk1 waves in the Drosophila syncytial blastoderm. We show that Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. Using mathematical modeling and surgical ligations, we demonstrate a fundamental distinction between S phase Cdk1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagate as passive phase waves. Our findings show that in Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events. PMID:27554859

  14. Rocket-Based Combined Cycle Activities in the Advanced Space Transportation Program Office

    NASA Technical Reports Server (NTRS)

    Hueter, Uwe; Turner, James

    1999-01-01

    NASA's Office of Aero-Space Technology (OAST) has established three major goals, referred to as, "The Three Pillars for Success". The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center (MSFC) in Huntsville, Ala. focuses on future space transportation technologies Under the "Access to Space" pillar. The Core Technologies Project, part of ASTP, focuses on the reusable technologies beyond those being pursued by X-33. One of the main activities over the past two and a half years has been on advancing the rocket-based combined cycle (RBCC) technologies. In June of last year, activities for reusable launch vehicle (RLV) airframe and propulsion technologies were initiated. These activities focus primarily on those technologies that support the decision to determine the path this country will take for Space Shuttle and RLV. This year, additional technology efforts in the reusable technologies will be awarded. The RBCC effort that was completed early this year was the initial step leading to flight demonstrations of the technology for space launch vehicle propulsion.

  15. Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure-activity relationship study.

    PubMed

    Ho, Si-Han Sherman; Sim, Mei-Yi; Yee, Wei-Loong Sherman; Yang, Tianming; Yuen, Shyi-Peng John; Go, Mei-Lin

    2015-11-01

    The anticancer agent YM155 is widely investigated as a specific survivin suppressant. More recently, YM155 was found to induce DNA damage and this has raised doubts as to whether survivin is its primary target. In an effort to assess the contribution of DNA damage to the anticancer activity of YM155, several analogs were prepared and evaluated for antiproliferative activity on malignant cells, participation in DNA intercalation and free radical generation by redox cycling. The intact positively charged scaffold was found to be essential for antiproliferative activity and intercalation but was less critical for redox cycling where the minimal requirement was a pared down bicyclic quinone. Side chain requirements at the N(1) and N(3) positions of the scaffold were more alike for redox cycling and intercalation than antiproliferative activity, underscoring yet again, the limited structural overlaps for these activities. Furthermore, antiproliferative activities were poorly correlated to DNA intercalation and redox cycling. Potent antiproliferative activity (IC50 9-23 nM), exceeding that of YM155, was found for a minimally substituted methyl analog AB7. Like YM155 and other dioxonaphthoimidazoliums, AB7 was a modest DNA intercalator but with weak redox cycling activity. Thus, the capacity of this scaffold to inflict direct DNA damage leading to cell death may not be significant and YM155 should not be routinely classified as a DNA damaging agent. PMID:26433618

  16. Case report of FLT3-ITD-positive AML patient 11 years after living donor liver transplantation.

    PubMed

    Taniai, N; Yoshida, H; Kawano, Y; Uchida, E

    2014-04-01

    With the increasing number of long-term survivors of living donor liver transplantation, the occurrence of secondary cancer is sometimes reported. Solid tumors such as lymphomas are mainly observed. However, only 8 cases of leukemia have been reported so far. For patients younger than 15 years old, leukemia developed in 4 within 3 years after the liver transplantation, whereas acute lymphoblastic leukemia developed in only 1 patient. This is the first case report of a patient in whom FLT3-ITD-positive acute myeloid leukemia (AML) developed more than 10 years after living donor liver transplantation for congenital biliary atresia. AML developed in a 14-year-old boy 11 years after living donor liver transplantation from his father. The patient received the transplant at the age of 3 years and was treated with tacrolimus and methylprednisolone for transplant rejection. Eleven years posttransplantation, he visited the hospital with general malaise and anemia. Blood tests revealed an elevated white blood cell count of 60,100/μL, and the patient was diagnosed with AML. Chromosome analysis revealed a t(6; 9) (p23 q34) translocation; moreover, genetic testing revealed a FLT3-ITD-positive mutation. We started treatment in accordance with the Tokyo Children's Cancer Study Group AML99 protocol. With chemotherapy treatment, the patient achieved complete remission. After chemotherapy, we performed stem cell transplantation from his father. Other patients were reported in relatively early stages after liver transplantation, but our case was more than 10 years posttransplantation. The association with the onset of congenital bile duct atresia and leukemia is still not clear, but we consider the possibility that long-term immunosuppressive drugs contribute to developing leukemia. PMID:24767404

  17. E-cigarette use and intentions to smoke among 10-11-year-old never-smokers in Wales

    PubMed Central

    Moore, Graham F; Littlecott, Hannah J; Moore, Laurence; Ahmed, Nilufar; Holliday, Jo

    2016-01-01

    Background E-cigarettes are seen by some as offering harm reduction potential, where used effectively as smoking cessation devices. However, there is emerging international evidence of growing use among young people, amid concerns that this may increase tobacco uptake. Few UK studies examine the prevalence of e-cigarette use in non-smoking children or associations with intentions to smoke. Methods A cross-sectional survey of year 6 (10–11-year-old) children in Wales. Approximately 1500 children completed questions on e-cigarette use, parental and peer smoking, and intentions to smoke. Logistic regression analyses among never smoking children, adjusted for school-level clustering, examined associations of smoking norms with e-cigarette use, and of e-cigarette use with intentions to smoke tobacco within the next 2 years. Results Approximately 6% of year 6 children, including 5% of never smokers, reported having used an e-cigarette. By comparison to children whose parents neither smoked nor used e-cigarettes, children were most likely to have used an e-cigarette if parents used both tobacco and e-cigarettes (OR=3.40; 95% CI 1.73 to 6.69). Having used an e-cigarette was associated with intentions to smoke (OR=3.21; 95% CI 1.66 to 6.23). While few children reported that they would smoke in 2 years’ time, children who had used an e-cigarette were less likely to report that they definitely would not smoke tobacco in 2 years’ time and were more likely to say that they might. Conclusions E-cigarettes represent a new form of childhood experimentation with nicotine. Findings are consistent with a hypothesis that children use e-cigarettes to imitate parental and peer smoking behaviours, and that e-cigarette use is associated with weaker antismoking intentions. PMID:25535293

  18. Quality Control of 11-Year Hourly Rain Gauge Data Over CONUS Based on Radar and Atmospheric Environmental Data

    NASA Astrophysics Data System (ADS)

    Qi, Y.

    2015-12-01

    Rain gauge networks have provided primary in situ observations of precipitation for over centuries and are widely used in meteorological and hydrological operations. In the last several decades, many new automated rain gauge networks were deployed to increase the spatial coverage and resolution of the precipitation observations. However, automated gauges are subject to a range of error sources, including clogging by clutter or frozen precipitation, undercatch in strong wind, wind turbulence, evaporative losses, double tipping of the sensor, or signal failure. Quality control of the gauge data has been a challenge, especially at hourly or sub-hourly scales. The current study takes advantage of a high-resolution, radar-based quantitative precipitation estimation (QPE) and develops an automated gauge data quality control (QC) using the radar QPE and atmospheric environmental data. The gauge QC technique compares hourly gauge observations with the radar QPE and identifies five types of potentially erroneous gauge data: 1) stuck gauges; 2) false precipitation; 3) frozen gauges; 4) spurious low outlier; and 5) spurious high outlier. An 11-year dataset (2001-2011) of hourly gauge observations, including 1) Hydrometeorological Automated Data System (HADS); 2) US Climate Reference Network (USCRN) and 3) Automated Surface Observing System (ASOS) networks obtained from the National Climatic Data Center (NCDC), were analyzed through the new gauge QC process. The analysis indicates that during the winter months (Dec-Feb), ~6% of the gauges per hour was in a below freezing environment and would not be able to provide reliable precipitation observations. On average, ~1.5% of gauges per hour were found stuck and ~1% reported false precipitation. Detailed results will be presented at the conference.

  19. Propulsion/ASME Rocket-Based Combined Cycle Activities in the Advanced Space Transportation Program Office

    NASA Technical Reports Server (NTRS)

    Hueter, Uwe; Turner, James

    1998-01-01

    NASA's Office Of Aeronautics and Space Transportation Technology (OASTT) has establish three major coals. "The Three Pillars for Success". The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center in Huntsville,Ala. focuses on future space transportation technologies under the "Access to Space" pillar. The Advanced Reusable Technologies (ART) Project, part of ASTP, focuses on the reusable technologies beyond those being pursued by X-33. The main activity over the past two and a half years has been on advancing the rocket-based combined cycle (RBCC) technologies. In June of last year, activities for reusable launch vehicle (RLV) airframe and propulsion technologies were initiated. These activities focus primarily on those technologies that support the year 2000 decision to determine the path this country will take for Space Shuttle and RLV. In February of this year, additional technology efforts in the reusable technologies were awarded. The RBCC effort that was completed early this year was the initial step leading to flight demonstrations of the technology for space launch vehicle propulsion. Aerojet, Boeing-Rocketdyne and Pratt & Whitney were selected for a two-year period to design, build and ground test their RBCC engine concepts. In addition, ASTROX, Pennsylvania State University (PSU) and University of Alabama in Huntsville also conducted supporting activities. The activity included ground testing of components (e.g., injectors, thrusters, ejectors and inlets) and integrated flowpaths. An area that has caused a large amount of difficulty in the testing efforts is the means of initiating the rocket combustion process. All three of the prime contractors above were using silane (SiH4) for ignition of the thrusters. This follows from the successful use of silane in the NASP program for scramjet ignition. However, difficulties were immediately encountered when silane (an 80/20 mixture of hydrogen/silane) was used for rocket

  20. Effects of Cycling Conditions of Active Material From Discharged Ni Positive Plates Studied by Inelastic Neutron Scattering Spectroscopy

    NASA Technical Reports Server (NTRS)

    Eckert, Juergen; Varma, Ravi; Diebolt, Lisa; Reid, Margaret

    1998-01-01

    The objectives of this presentation are: identify atomic-level signatures of electrochemical activity of the active material on the Ni positive plates of Ni-H2 batteries, relate finding to cycling conditions and histories, and develop INS spectroscopy as a non-destructive testing technique for the evaluation of Ni-positive plates of Ni-H2 batteries.

  1. Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation

    PubMed Central

    Sharma, Naveen; Okere, Isidore C; Brunengraber, Daniel Z; McElfresh, Tracy A; King, Kristen L; Sterk, Joseph P; Huang, Hazel; Chandler, Margaret P; Stanley, William C

    2005-01-01

    A high rate of cardiac work increases citric acid cycle (CAC) turnover and flux through pyruvate dehydrogenase (PDH); however, the mechanisms for these effects are poorly understood. We tested the hypotheses that an increase in cardiac energy expenditure: (1) activates PDH and reduces the product/substrate ratios ([NADH]/[NAD+] and [acetyl-CoA]/[CoA-SH]); and (2) increases the content of CAC intermediates. Measurements were made in anaesthetized pigs under control conditions and during 15 min of a high cardiac workload induced by dobutamine (Dob). A third group was made hyperglycaemic (14 mm) to stimulate flux through PDH during the high work state (Dob + Glu). Glucose and fatty acid oxidation were measured with 14C-glucose and 3H-oleate. Compared with control, the high workload groups had a similar increase in myocardial oxygen consumption ( and cardiac power. Dob increased PDH activity and glucose oxidation above control, but did not reduce the [NADH]/[NAD+] and [acetyl-CoA]/[CoA-SH] ratios, and there were no differences between the Dob and Dob + Glu groups. An additional group was treated with Dob + Glu and oxfenicine (Oxf) to inhibit fatty acid oxidation: this increased [CoA-SH] and glucose oxidation compared with Dob; however, there was no further activation of PDH or decrease in the [NADH]/[NAD+] ratio. Content of the 4-carbon CAC intermediates succinate, fumarate and malate increased 3-fold with Dob, but there was no change in citrate content, and the Dob + Glu and Dob + Glu + Oxf groups were not different from Dob. In conclusion, compared with normal conditions, at high myocardial energy expenditure (1) the increase in flux through PDH is regulated by activation of the enzyme complex and continues to be partially controlled through inhibition by fatty acid oxidation, and (2) there is expansion of the CAC pool size at the level of 4-carbon intermediates that is largely independent of myocardial fatty acid oxidation. PMID:15550462

  2. Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response

    PubMed Central

    Alexandrou, Aris T.

    2014-01-01

    Abstract Significance: There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated and remains controversial, LDIR is shown to induce temporary but significant adaptive responses in mammalian cells and animals. The mechanisms guiding the mitochondrial function in LDIR-induced adaptive response represent a unique communication between DNA damage and cellular metabolism. Elucidation of the LDIR-regulated mitochondrial activity may reveal new mechanisms adjusting cellular function to cope with hazardous environmental stress. Recent Advances: Key cell cycle regulators, including Cyclin D1/CDK4 and Cyclin B1/cyclin-dependent kinase 1 (CDK1) complexes, are actively involved in the regulation of mitochondrial functions via phosphorylation of their mitochondrial targets. Accumulating new evidence supports a concept that the Cyclin B1/CDK1 complex acts as a mediator in the cross talk between radiation-induced DNA damage and mitochondrial functions to coordinate cellular responses to low-level genotoxic stresses. Critical Issues: The LDIR-mediated mitochondrial activity via Cyclin B1/CDK1 regulation is an irreplaceable network that is able to harmonize vital cellular functions with adjusted mitochondrial metabolism to enhance cellular homeostasis. Future Directions: Further investigation of the coordinative mechanism that regulates mitochondrial activities in sublethal stress conditions, including LDIR, will reveal new insights of how cells cope with genotoxic injury and will be vital for future targeted therapeutic interventions that reduce environmental injury and cancer risk. Antioxid. Redox Signal. 20, 1463–1480. PMID:24180340

  3. Breakpoints in ventilation, cerebral and muscle oxygenation, and muscle activity during an incremental cycling exercise

    PubMed Central

    Racinais, Sebastien; Buchheit, Martin; Girard, Olivier

    2014-01-01

    The aim of this study was to locate the breakpoints of cerebral and muscle oxygenation and muscle electrical activity during a ramp exercise in reference to the first and second ventilatory thresholds. Twenty-five cyclists completed a maximal ramp test on an electromagnetically braked cycle-ergometer with a rate of increment of 25 W/min. Expired gazes (breath-by-breath), prefrontal cortex and vastus lateralis (VL) oxygenation [Near-infrared spectroscopy (NIRS)] together with electromyographic (EMG) Root Mean Square (RMS) activity for the VL, rectus femoris (RF), and biceps femoris (BF) muscles were continuously assessed. There was a non-linear increase in both cerebral deoxyhemoglobin (at 56 ± 13% of the exercise) and oxyhemoglobin (56 ± 8% of exercise) concomitantly to the first ventilatory threshold (57 ± 6% of exercise, p > 0.86, Cohen's d < 0.1). Cerebral deoxyhemoglobin further increased (87 ± 10% of exercise) while oxyhemoglobin reached a plateau/decreased (86 ± 8% of exercise) after the second ventilatory threshold (81 ± 6% of exercise, p < 0.05, d > 0.8). We identified one threshold only for muscle parameters with a non-linear decrease in muscle oxyhemoglobin (78 ± 9% of exercise), attenuation in muscle deoxyhemoglobin (80 ± 8% of exercise), and increase in EMG activity of VL (89 ± 5% of exercise), RF (82 ± 14% of exercise), and BF (85 ± 9% of exercise). The thresholds in BF and VL EMG activity occurred after the second ventilatory threshold (p < 0.05, d > 0.6). Our results suggest that the metabolic and ventilatory events characterizing this latter cardiopulmonary threshold may affect both cerebral and muscle oxygenation levels, and in turn, muscle recruitment responses. PMID:24782786

  4. Active Trans-Plasma Membrane Water Cycling in Yeast Is Revealed by NMR

    PubMed Central

    Zhang, Yajie; Poirier-Quinot, Marie; Springer, Charles S.; Balschi, James A.

    2011-01-01

    Plasma membrane water transport is a crucial cellular phenomenon. Net water movement in response to an osmotic gradient changes cell volume. Steady-state exchange of water molecules, with no net flux or volume change, occurs by passive diffusion through the phospholipid bilayer and passage through membrane proteins. The hypothesis is tested that plasma membrane water exchange also correlates with ATP-driven membrane transport activity in yeast (Saccharomyces cerevisiae). Longitudinal 1H2O NMR relaxation time constant (T1) values were measured in yeast suspensions containing extracellular relaxation reagent. Two-site-exchange analysis quantified the reversible exchange kinetics as the mean intracellular water lifetime (τi), where τi−1 is the pseudo-first-order rate constant for water efflux. To modulate cellular ATP, yeast suspensions were bubbled with 95%O2/5%CO2 (O2) or 95%N2/5%CO2 (N2). ATP was high during O2, and τi−1 was 3.1 s−1 at 25°C. After changing to N2, ATP decreased and τi−1 was 1.8 s−1. The principal active yeast ion transport protein is the plasma membrane H+-ATPase. Studies using the H+-ATPase inhibitor ebselen or a yeast genetic strain with reduced H+-ATPase found reduced τi−1, notwithstanding high ATP. Steady-state water exchange correlates with H+-ATPase activity. At volume steady state, water is cycling across the plasma membrane in response to metabolic transport activity. PMID:22261073

  5. THREE-DIMENSIONAL FEATURES OF THE OUTER HELIOSPHERE DUE TO COUPLING BETWEEN THE INTERSTELLAR AND INTERPLANETARY MAGNETIC FIELDS. III. THE EFFECTS OF SOLAR ROTATION AND ACTIVITY CYCLE

    SciTech Connect

    Pogorelov, Nikolai V.; Borovikov, Sergey N.; Zank, Gary P.; Ogino, Tatsuki E-mail: snb0003@uah.edu E-mail: ogino@stelab.nagoya-u.ac.jp

    2009-05-10

    We investigate the effects of the 11 year solar cycle and 25 day rotation period of the Sun on the interaction of the solar wind (SW) with the local interstellar medium (LISM). Our models take into account the partially ionized character of the LISM and include momentum and energy transfer between the ionized and neutral components. We assume that the interstellar magnetic field vector belongs to the hydrogen deflection plane as discovered in the SOHO SWAN experiment. This plane is inclined at an angle of about 60 deg. toward the ecliptic plane of the Sun, as suggested in recent publications relating the local interstellar cloud properties to the radio emission observed by Voyager 1. It is assumed that the latitudinal extent of the boundary between the slow and fast SW regions, as well as the angle between the Sun's rotation and magnetic-dipole axes, are periodic functions of time, while the polarity of the interstellar magnetic field changes sign every 11 years at the solar maximum. The global variation of the SW-LISM interaction pattern, the excursions of the termination shock and the heliopause, and parameter distributions in certain directions are investigated. The analysis of the behavior of the wavy heliospheric current sheet in the supersonic SW region shows the importance of neutral atoms on its dynamics.

  6. Control Activity in Support of NASA Turbine Based Combined Cycle (TBCC) Research

    NASA Technical Reports Server (NTRS)

    Stueber, Thomas J.; Vrnak, Daniel R.; Le, Dzu K.; Ouzts, Peter J.

    2010-01-01

    Control research for a Turbine Based Combined Cycle (TBCC) propulsion system is the current focus of the Hypersonic Guidance, Navigation, and Control (GN&C) discipline team. The ongoing work at the NASA Glenn Research Center (GRC) supports the Hypersonic GN&C effort in developing tools to aid the design of control algorithms to manage a TBCC airbreathing propulsion system during a critical operating period. The critical operating period being addressed in this paper is the span when the propulsion system transitions from one cycle to another, referred to as mode transition. One such tool, that is a basic need for control system design activities, is computational models (hereto forth referred to as models) of the propulsion system. The models of interest for designing and testing controllers are Control Development Models (CDMs) and Control Validation Models (CVMs). CDMs and CVMs are needed for each of the following propulsion system elements: inlet, turbine engine, ram/scram dual-mode combustor, and nozzle. This paper presents an overall architecture for a TBCC propulsion system model that includes all of the propulsion system elements. Efforts are under way, focusing on one of the propulsion system elements, to develop CDMs and CVMs for a TBCC propulsion system inlet. The TBCC inlet aerodynamic design being modeled is that of the Combined-Cycle Engine (CCE) Testbed. The CCE Testbed is a large-scale model of an aerodynamic design that was verified in a small-scale screening experiment. The modeling approach includes employing existing state-of-the-art simulation codes, developing new dynamic simulations, and performing system identification experiments on the hardware in the NASA GRC 10 by10-Foot Supersonic Wind Tunnel. The developed CDMs and CVMs will be available for control studies prior to hardware buildup. The system identification experiments on the CCE Testbed will characterize the necessary dynamics to be represented in CDMs for control design. These

  7. Active and long-lived permanent forearc deformation driven by the subduction seismic cycle

    NASA Astrophysics Data System (ADS)

    Aron Melo, Felipe Alejandro

    I have used geological, geophysical and engineering methods to explore mechanisms of upper plate, brittle deformation at active forearc regions. My dissertation particularly addresses the permanent deformation style experienced by the forearc following great subduction ruptures, such as the 2010 M w8.8 Maule, Chile and 2011 Mw9.0 Tohoku, Japan earthquakes. These events triggered large, shallow seismicity on upper plate normal faults above the rupture reaching Mw7.0. First I present new structural data from the Chilean Coastal Cordillera over the rupture zone of the Maule earthquake. The study area contains the Pichilemu normal fault, which produced the large crustal aftershocks of the megathrust event. Normal faults are the major neotectonic structural elements but reverse faults also exist. Crustal seismicity and GPS surface displacements show that the forearc experiences pulses of rapid coseismic extension, parallel to the heave of the megathrust, and slow interseismic, convergence-parallel shortening. These cycles, over geologic time, build the forearc structural grain, reactivating structures properly-oriented respect to the deformation field of each stage of the interplate cycle. Great subduction events may play a fundamental role in constructing the crustal architecture of extensional forearc regions. Static mechanical models of coseismic and interseismic upper plate deformation are used to explore for distinct features that could result from brittle fracturing over the two stages of the interplate cycle. I show that the semi-elliptical outline of the first-order normal faults along the Coastal Cordillera may define the location of a characteristic, long-lived megathrust segment. Finally, using data from the Global CMT catalog I analyzed the seismic behavior through time of forearc regions that have experienced great subduction ruptures >Mw7.7 worldwide. Between 61% and 83% of the cases where upper plate earthquakes exhibited periods of increased seismicity

  8. Continued Development of the Rapid Cycle Amine (RCA) System for Advanced Extravehicular Activity Systems

    NASA Technical Reports Server (NTRS)

    Papale, William; Chullen, Cinda; Campbell, Colin; Conger, Bruce; McMillin, Summer; Jeng, Frank

    2014-01-01

    Development activities related to the Rapid Cycle Amine (RCA) Carbon Dioxide (CO2) and Humidity control system have progressed to the point of integrating the RCA into an advanced Primary Life Support System (PLSS 2.0) to evaluate the interaction of the RCA among other PLSS components in a ground test environment. The RCA 2.0 assembly (integrated into PLSS 2.0) consists of a valve assembly with commercial actuator motor, a sorbent canister, and a field-programmable gate array (FPGA)-based process node controller. Continued design and development activities for RCA 3.0 have been aimed at optimizing the canister size and incorporating greater fidelity in the valve actuator motor and valve position feedback design. Further, the RCA process node controller is envisioned to incorporate a higher degree of functionality to support a distributed PLSS control architecture. This paper will describe the progression of technology readiness levels of RCA 1.0, 2.0 and 3.0 along with a review of the design and manufacturing successes and challenges for 2.0 and 3.0 units. The anticipated interfaces and interactions with the PLSS 2.0/2.5/3.0 assemblies will also be discussed.

  9. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

    PubMed

    Roberts, Bracken F; Iyamu, Iredia D; Lee, Sukjun; Lee, Eunyoung; Ayong, Lawrence; Kyle, Dennis E; Yuan, Yu; Manetsch, Roman; Chakrabarti, Debopam

    2016-04-01

    We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials. PMID:27054067

  10. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

    PubMed Central

    Roberts, Bracken F.; Iyamu, Iredia D.; Lee, Sukjun; Lee, Eunyoung; Ayong, Lawrence; Kyle, Dennis E.; Yuan, Yu; Manetsch, Roman; Chakrabarti, Debopam

    2016-01-01

    We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials. PMID:27054067

  11. Deleterious effect of suboptimal diet on rest-activity cycle in Anastrepha ludens manifests itself with age

    PubMed Central

    Chiu, Joanna C.; Kaub, Kevin; Zou, Sige; Liedo, Pablo; Altamirano-Robles, Leopoldo; Ingram, Donald; Carey, James R.

    2013-01-01

    Activity patterns and sleep-wake cycles are among the physiological processes that change most prominently as animals age, and are often good indicators of healthspan. In this study, we used the video-based high-resolution Behavioral Monitoring System (BMS) to monitor the daily activity cycle of tephritid fruit flies Anastrepha ludens over their lifetime. Surprisingly, there was no dramatic change in activity profile with respect to age if flies were consistently fed with a nutritionally balanced diet. However, if flies were fed with sugar-only diet, their activity profile decreased in amplitude at old age, suggesting that suboptimal diet affected activity patterns, and its detrimental effect may not manifest itself until the animal ages. Moreover, by simulating different modes of behavior monitoring with a range of resolution and comparing the resulting conclusions, we confirmed the superior performance of video-based monitoring using high-resolution BMS in accurately representing activity patterns in an insect model. PMID:23639915

  12. Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years

    PubMed Central

    Simpson, Angela; Lazic, Nevena; Belgrave, Danielle C.M.; Johnson, Phil; Bishop, Christopher; Mills, Clare; Custovic, Adnan

    2015-01-01

    Background The relationship between sensitization to allergens and disease is complex. Objective We sought to identify patterns of response to a broad range of allergen components and investigate associations with asthma, eczema, and hay fever. Methods Serum specific IgE levels to 112 allergen components were measured by using a multiplex array (Immuno Solid-phase Allergen Chip) in a population-based birth cohort. Latent variable modeling was used to identify underlying patterns of component-specific IgE responses; these patterns were then related to asthma, eczema, and hay fever. Results Two hundred twenty-one of 461 children had IgE to 1 or more components. Seventy-one of the 112 components were recognized by 3 or more children. By using latent variable modeling, 61 allergen components clustered into 3 component groups (CG1, CG2, and CG3); protein families within each CG were exclusive to that group. CG1 comprised 27 components from 8 plant protein families. CG2 comprised 7 components of mite allergens from 3 protein families. CG3 included 27 components of plant, animal, and fungal origin from 12 protein families. Each CG included components from different biological sources with structural homology and also nonhomologous proteins arising from the same biological source. Sensitization to CG3 was most strongly associated with asthma (odds ratio [OR], 8.20; 95% CI, 3.49-19.24; P < .001) and lower FEV1 (P < .001). Sensitization to CG1 was associated with hay fever (OR, 12.79; 95% CI, 6.84-23.90; P < .001). Sensitization to CG2 was associated with both asthma (OR, 3.60; 95% CI, 2.05-6.29) and hay fever (OR, 2.52; 95% CI, 1.38-4.61). Conclusions Latent variable modeling with a large number of allergen components identified 3 patterns of IgE responses, each including different protein families. In 11-year-old children the pattern of response to components of multiple allergens appeared to be associated with current asthma and hay fever but not eczema. PMID

  13. Two-dimensional surface velocity field across the Asal Rift (Afar Depression) from 11 years of InSAR data

    NASA Astrophysics Data System (ADS)

    Tomic, J.; Peltzer, G.; Doubre, C.

    2010-12-01

    We analyze two-dimensional surface velocity maps of the 200x400 km2 region covering the Asal Rift located at the western tip of the Aden Ridge, using the 1997-2008 archive of InSAR data from the RADARSAT satellite. The large phase signal due to turbulent tropospheric conditions over the Afar region is mostly removed from the 11-year average line of sight (LOS) velocity maps, revealing a clear deformation signal across the rift. Assuming the horizontal velocity to be parallel to the direction predicted by the Arabia/Somalia rotation pole (Vigny et al., 2007), we compute the fields of the vertical and horizontal components of the velocity from the ascending and descending line of sight (LOS) velocity maps. The horizontal velocity field shows the divergence between the Arabia and Somalia plates concentrated along the Asal rift, and veering toward the south-west, into the Derella-Gaggade basin system. The Asal rift shoulders open at a rate of ~15 mm/yr, while the horizontal velocity decreases away from the rift down to the plate motion rate of ~11-12 mm/yr. The vertical velocity field shows a ~60 km wide zone of doming centered over the rift associated with shoulder uplift and subsidence of the rift inner floor. The differential movement between the shoulders and the rift floor is accommodated by two main antithetic faults: the south-dipping Fault γ well developed in the topography and the recent north-dipping Fault E with a small topographic scarp. We explain the observed velocity field with 2D-forward and 3D-inverse models combining dislocations of rectangular elements in an elastic half-space. The forward model allows us to estimate the overall geometry and rates of an inflating body at 5 km depth (represented by a combination of a dike and a horizontal sill) and creep on two faults. The least-squares inverse model shows an inflating body located under the Fieale volcano expanding at 2 106 m3/yr. Faults bordering the rift show down-dip and opening motion especially

  14. Changes in the activities of key enzymes of glycolysis during the cell cycle in yeast: a rectification.

    PubMed

    de Koning, W; Groeneveld, K; Oehlen, L J; Berden, J A; van Dam, K

    1991-04-01

    Activities of glycolytic enzymes were determined in elutriation fractionated cultures of Saccharomyces cerevisiae grown on different carbon sources. Almost pure fractions of single cells at the G1 state of cell division were obtained for some of the growth conditions tested, whereas other stages were enriched in particular fractions. Specific activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase were found to be constant during the cell cycle, as reported by van Doorn et al. (1988a), Journal of Bacteriology 170, 4808-4815, and (1988b), Journal of General Microbiology 134, 785-790. In contrast to the earlier reports, the activities of hexokinase, phosphofructokinase, pyruvate kinase and trehalase were also constant in different states of the cell cycle. For hexokinase and phosphofructokinase it was shown that the apparent specific activity in a cell-free extract strongly diminished when extracts contained less that 0.5-1 mg protein ml-1. In the experiments of van Doorn et al. (1988a) the protein content of the outer fractions was up to 20 times lower than that of the central fractions, suggesting an alternative explanation for the observed changes in enzyme activities during the cell cycle. Therefore, we want to rectify the observations presented by van Doorn et al. (1988a), and conclude that the activities of the glycolytic enzymes do not vary greatly during the cell cycle of S. cervisiae. PMID:1856683

  15. Impact of repeated dry-wet cycles on soil greenhouse gas emissions, extracellular enzyme activity and nutrient cycling in a temperate forest

    NASA Astrophysics Data System (ADS)

    Leitner, Sonja; Zimmermann, Michael; Bockholt, Jan; Schartner, Markus; Brugner, Paul; Holtermann, Christian; Zechmeister-Boltenstern, Sophie

    2014-05-01

    Climate change research predicts that both frequency and intensity of weather extremes such as long drought periods and heavy rainfall events will increase in mid Europe over the next decades. Soil moisture is one of the major factors controlling microbial soil processes, and it has been widely agreed that feedback effects between altered precipitation and changed soil fluxes of the greenhouse gases CO2, CH4 and N2O could intensify climate change. In a field experiment in an Austrian beech forest, we established a precipitation manipulation experiment, which will be conducted for 3 years. We use roofs to exclude rainfall from reaching the forest soil and simulate drought periods, and a sprinkler system to simulate heavy rainfall events. We applied repeated dry-wet cycles in two intensities: one treatment received 6 cycles of 1 month drought followed by 75mm irrigation within 2 hours, and a parallel treatment received 3 cycles of 2 months drought followed by 150mm irrigation within 3 hours. We took soil samples 1 day before, 1 day after and 1 week after rewetting events and analyzed them for soil nutrients and extracellular enzyme activities. Soil fluxes of CO2, N2O and CH4 were constantly monitored with an automated flux chamber system, and environmental parameters were recorded via dataloggers. In addition, we determined fluxes and nutrient concentrations of bulk precipitation, throughfall, stemflow, litter percolate and soil water. Next we plan to analyze soil microbial community composition via PLFAs to investigate microbial stress resistance and resilience, and we will use ultrasonication to measure soil aggregate stability and protection of soil organic matter in stressed and control plots. The results of the first year show that experimental rainfall manipulation has influenced soil extracellular enzymes. Potential phenoloxidase activity was significantly reduced in stressed treatments compared to control plots. All measured hydrolytic enzymes (cellulase

  16. Bisphenol A, phthalates and lead and learning and behavioral problems in Canadian children 6-11 years of age: CHMS 2007-2009.

    PubMed

    Arbuckle, Tye E; Davis, Karelyn; Boylan, Khrista; Fisher, Mandy; Fu, Jingshan

    2016-05-01

    Childhood developmental disorders and related problems such as learning disabilities and attention deficit hyperactivity disorder (ADHD) account for a growing burden on the family, education and health care systems. Exposure to environmental chemicals such as bisphenol A (BPA) and phthalates may play a role in the development of child behavioral problems. Using cross-sectional data from Cycle 1 of the Canadian Health Measures Survey (CHMS), we examined the potential association between urinary concentrations of BPA and various phthalate metabolites and child learning and behavioral problems, considering important covariates such as gender, blood lead and environmental tobacco smoke (ETS). The Strengths and Difficulties Questionnaire (SDQ) outcomes of interest were emotional symptoms, hyperactivity/inattention, and a total difficulties score with borderline and abnormal scores grouped together and compared with children with normal scores. Other outcomes studied included any reported learning disability, a subset of learning disabilities reported as ADD/ADHD (attention deficit disorder) and use of psychotropic medications in the past month. Among children ages 6-11 years, the prevalences of any learning disability, ADD, and ADHD were 8.7%, 1.5% and 2.8%, respectively. Estimated prevalences for SDQ hyperactivity/inattention, emotional symptoms and total difficulties scores were 16.9%, 15.0%, and 13.0%, respectively. Child's urinary BPA was associated with taking psychotropic medications (OR 1.59; 95% CI 1.05-2.40). Urinary MBzP concentration was significantly associated with emotional symptoms in girls (OR 1.38 95% CI 1.09-1.75) but not in boys (OR 1.05 95% CI 0.82-1.36).) Blood lead was significantly associated with several of the outcomes examined, with a significant interaction observed between prenatal smoking and blood lead for the total difficulties score (OR=10.57; 95% CI 2.81-39.69 vs. OR=1.98; 95% CI 1.41-2.79 if mother did not smoke during pregnancy

  17. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.

    PubMed

    Cekan, Pavol; Hasegawa, Keisuke; Pan, Yu; Tubman, Emily; Odde, David; Chen, Jin-Qiu; Herrmann, Michelle A; Kumar, Sheetal; Kalab, Petr

    2016-04-15

    The coordination of cell cycle progression with the repair of DNA damage supports the genomic integrity of dividing cells. The function of many factors involved in DNA damage response (DDR) and the cell cycle depends on their Ran GTPase-regulated nuclear-cytoplasmic transport (NCT). The loading of Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical for NCT activity. However, the role of RCC1 or Ran⋅GTP in promoting cell proliferation or DDR is not clear. We show that RCC1 overexpression in normal cells increased cellular Ran⋅GTP levels and accelerated the cell cycle and DNA damage repair. As a result, normal cells overexpressing RCC1 evaded DNA damage-induced cell cycle arrest and senescence, mimicking colorectal carcinoma cells with high endogenous RCC1 levels. The RCC1-induced inhibition of senescence required Ran and exportin 1 and involved the activation of importin β-dependent nuclear import of 53BP1, a large NCT cargo. Our results indicate that changes in the activity of the Ran⋅GTP-regulated NCT modulate the rate of the cell cycle and the efficiency of DNA repair. Through the essential role of RCC1 in regulation of cellular Ran⋅GTP levels and NCT, RCC1 expression enables the proliferation of cells that sustain DNA damage. PMID:26864624

  18. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence

    PubMed Central

    Cekan, Pavol; Hasegawa, Keisuke; Pan, Yu; Tubman, Emily; Odde, David; Chen, Jin-Qiu; Herrmann, Michelle A.; Kumar, Sheetal; Kalab, Petr

    2016-01-01

    The coordination of cell cycle progression with the repair of DNA damage supports the genomic integrity of dividing cells. The function of many factors involved in DNA damage response (DDR) and the cell cycle depends on their Ran GTPase–regulated nuclear–cytoplasmic transport (NCT). The loading of Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical for NCT activity. However, the role of RCC1 or Ran⋅GTP in promoting cell proliferation or DDR is not clear. We show that RCC1 overexpression in normal cells increased cellular Ran⋅GTP levels and accelerated the cell cycle and DNA damage repair. As a result, normal cells overexpressing RCC1 evaded DNA damage–induced cell cycle arrest and senescence, mimicking colorectal carcinoma cells with high endogenous RCC1 levels. The RCC1-induced inhibition of senescence required Ran and exportin 1 and involved the activation of importin β–dependent nuclear import of 53BP1, a large NCT cargo. Our results indicate that changes in the activity of the Ran⋅GTP–regulated NCT modulate the rate of the cell cycle and the efficiency of DNA repair. Through the essential role of RCC1 in regulation of cellular Ran⋅GTP levels and NCT, RCC1 expression enables the proliferation of cells that sustain DNA damage. PMID:26864624

  19. Induction of Apoptosis and Antiproliferative Activity of Naringenin in Human Epidermoid Carcinoma Cell through ROS Generation and Cell Cycle Arrest

    PubMed Central

    Jafri, Asif; Ahmad, Sheeba; Afzal, Mohammad; Arshad, Md

    2014-01-01

    A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide range of pharmacological activities. The search for antiproliferative agents that reduce skin carcinoma is a task of great importance. The objective of this study was to analyze the anti-proliferative and apoptotic mechanism of naringenin using MTT assay, DNA fragmentation, nuclear condensation, change in mitochondrial membrane potential, cell cycle kinetics and caspase-3 as biomarkers and to investigate the ability to induce reactive oxygen species (ROS) initiating apoptotic cascade in human epidermoid carcinoma A431 cells. Results showed that naringenin exposure significantly reduced the cell viability of A431 cells (p<0.01) with a concomitant increase in nuclear condensation and DNA fragmentation in a dose dependent manner. The intracellular ROS generation assay showed statistically significant (p<0.001) dose-related increment in ROS production for naringenin. It also caused naringenin-mediated epidermoid carcinoma apoptosis by inducing mitochondrial depolarization. Cell cycle study showed that naringenin induced cell cycle arrest in G0/G1 phase of cell cycle and caspase-3 analysis revealed a dose dependent increment in caspase-3 activity which led to cell apoptosis. This study confirms the efficacy of naringenin that lead to cell death in epidermoid carcinoma cells via inducing ROS generation, mitochondrial depolarization, nuclear condensation, DNA fragmentation, cell cycle arrest in G0/G1 phase and caspase-3 activation. PMID:25330158

  20. Prevalence of Sexual Dysfunction and its Associated Factors in Women Aged 40–65 Years with 11 Years or More of Formal Education: A Population-Based Household Survey

    PubMed Central

    Valadares, Ana L. R.; Pinto-Neto, Aarão M.; Osis, Maria J.; Sousa, Maria H.; Costa-Paiva, Lúcia; Conde, Délio M.

    2008-01-01

    OBJECTIVE To evaluate the prevalence of sexual dysfunction and its associated factors in middle-aged women with 11 years or more of formal education. METHODS A cross-sectional, population-based study was carried out using an anonymous, self-response questionnaire. A total of 315 Brazilian-born women, 40–65 years of age with 11 years or more of schooling, participated in the study. The instrument used in the evaluation was based on the Short Personal Experiences Questionnaire. Sexual dysfunction was calculated from the mean score of sexual responsiveness (pleasure in sexual activities, excitation and orgasm), frequency of sexual activities and libido. Sociodemographic and clinical factors were evaluated. Poisson multiple regression analysis was carried out and the prevalence ratios with respective 95% confidence intervals (95%CI) were calculated. RESULTS The prevalence of sexual dysfunction was 35.9% among our study population. Multiple regression analysis showed that sexual dysfunction was positively associated with older age (prevalence ratios=1.04; 95%CI:1.01–1.07) and with the presence of hot flashes (prevalence ratios=1.37; 95%CI:1.04–1.80). Having a sexual partner (PR=0.47; 95%CI:0.34–0.65) and feeling well or excellent (prevalence ratios= 0.68; 95%CI: 0.52–0.88) were factors associated with lower sexual dysfunction scores. CONCLUSIONS Sexual dysfunction was present in more than one-third of women that were 40–65 years of age with 11 years or more of formal education. Within that age group, older age and hot flashes were associated with higher sexual dysfunction scores, whereas feeling well and having a sexual partner were associated with better sexuality. PMID:19061000

  1. Millennial changes in North American wildfire and soil activity over the last glacial cycle

    NASA Astrophysics Data System (ADS)

    Fischer, Hubertus; Schüpbach, Simon; Gfeller, Gideon; Bigler, Matthias; Röthlisberger, Regine; Erhardt, Tobias; Stocker, Thomas F.; Mulvaney, Robert; Wolff, Eric W.

    2015-09-01

    Climate changes in the North Atlantic region during the last glacial cycle were dominated by the slow waxing and waning of the North American ice sheet as well as by intermittent, millennial-scale Dansgaard-Oeschger climate oscillations. However, prior to the last deglaciation, the responses of North American vegetation and biomass burning to these climate variations are uncertain. Ammonium in Greenland ice cores, a product from North American soil emissions and biomass burning events, can help to fill this gap. Here we use continuous, high-resolution measurements of ammonium concentrations between 110,000 to 10,000 years ago from the Greenland NGRIP and GRIP ice cores to reconstruct North American wildfire activity and soil ammonium emissions. We find that on orbital timescales soil emissions increased under warmer climate conditions when vegetation expanded northwards into previously ice-covered areas. For millennial-scale interstadial warm periods during Marine Isotope Stage 3, the fire recurrence rate increased in parallel to the rapid warmings, whereas soil emissions rose more slowly, reflecting slow ice shrinkage and delayed ecosystem changes. We conclude that sudden warming events had little impact on soil ammonium emissions and ammonium transport to Greenland, but did result in a substantial increase in the frequency of North American wildfires.

  2. A hand speed-duty cycle equation for estimating the ACGIH hand activity level rating.

    PubMed

    Akkas, Oguz; Azari, David P; Chen, Chia-Hsiung Eric; Hu, Yu Hen; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David; Radwin, Robert G

    2015-01-01

    An equation was developed for estimating hand activity level (HAL) directly from tracked root mean square (RMS) hand speed (S) and duty cycle (D). Table lookup, equation or marker-less video tracking can estimate HAL from motion/exertion frequency (F) and D. Since automatically estimating F is sometimes complex, HAL may be more readily assessed using S. Hands from 33 videos originally used for the HAL rating were tracked to estimate S, scaled relative to hand breadth (HB), and single-frame analysis was used to measure D. Since HBs were unknown, a Monte Carlo method was employed for iteratively estimating the regression coefficients from US Army anthropometry survey data. The equation: HAL = 10[e(-15:87+0:02D+2:25 ln S)/(1+e(-15:87+0:02D+2:25 ln S)], R(2) = 0.97, had a residual range ± 0.5 HAL. The S equation superiorly fits the Latko et al. ( 1997 ) data and predicted independently observed HAL values (Harris 2011) better (MSE = 0.16) than the F equation (MSE = 1.28). PMID:25343278

  3. A frequency-duty cycle equation for the ACGIH hand activity level.

    PubMed

    Radwin, Robert G; Azari, David P; Lindstrom, Mary J; Ulin, Sheryl S; Armstrong, Thomas J; Rempel, David

    2015-01-01

    A new equation for predicting the hand activity level (HAL) used in the American Conference for Government Industrial Hygienists threshold limit value®(TLV®) was based on exertion frequency (F) and percentage duty cycle (D). The TLV® includes a table for estimating HAL from F and D originating from data in Latko et al. (Latko WA, Armstrong TJ, Foulke JA, Herrin GD, Rabourn RA, Ulin SS, Development and evaluation of an observational method for assessing repetition in hand tasks. American Industrial Hygiene Association Journal, 58(4):278-285, 1997) and post hoc adjustments that include extrapolations outside of the data range. Multimedia video task analysis determined D for two additional jobs from Latko's study not in the original data-set, and a new nonlinear regression equation was developed to better fit the data and create a more accurate table. The equation, HAL = 6:56 ln D[F(1:31) /1+3:18 F(1:31), generally matches the TLV® HAL lookup table, and is a substantial improvement over the linear model, particularly for F>1.25 Hz and D>60% jobs. The equation more closely fits the data and applies the TLV® using a continuous function. PMID:25343340

  4. TOUSLED Kinase Activity Oscillates during the Cell Cycle and Interacts with Chromatin Regulators1

    PubMed Central

    Ehsan, Hashimul; Reichheld, Jean-Philippe; Durfee, Tim; Roe, Judith L.

    2004-01-01

    The TOUSLED (TSL)-like nuclear protein kinase family is highly conserved in plants and animals. tsl loss of function mutations cause pleiotropic defects in both leaf and flower development, and growth and initiation of floral organ primordia is abnormal, suggesting that basic cellular processes are affected. TSL is more highly expressed in exponentially growing Arabidopsis culture cells than in stationary, nondividing cells. While its expression remains constant throughout the cell cycle in dividing cells, TSL kinase activity is higher in enriched late G2/M-phase and G1-phase populations of Arabidopsis suspension culture cells compared to those in S-phase. tsl mutants also display an aberrant pattern and increased expression levels of the mitotic cyclin gene CycB1;1, suggesting that TSL represses CycB1;1 expression at certain times during development or that cells are delayed in mitosis. TSL interacts with and phosphorylates one of two Arabidopsis homologs of the nucleosome assembly/silencing protein Asf1 and histone H3, as in humans, and a novel plant SANT/myb-domain protein, TKI1, suggesting that TSL plays a role in chromatin metabolism. PMID:15047893

  5. Fluctuation of the CaS -sequestering activity of permeabilized sea urchin embryos during the cell cycle

    SciTech Connect

    Suprynowicz, F.A.; Mazia, D.

    1985-04-01

    The authors have followed the sequestration of CaS by intracellular compartments in sea urchin embryos through the first cell cycles. To gain biochemical access to these compartments, the embryos were permeabilized by brief exposure to an intense electric field. Sequestration was determined as the retention of tracer, UVCa, after filtration of aliquots on Millipore filters. The permeabilized cells sequester CaS at a constant rate for at least 20 min. The CaS -sequestering activities of embryos that are permeabilized at successive stages of the first cell cycle (one-cell stage) progressively increase to 5 times the initial level. The rate of sequestration is maximal during telophase and, in some populations of zygotes, is nearly as great throughout prophase. Over the course of the second cell cycle (two-cell stage), the activity undergoes a 2-fold oscillation that bears the same temporal relationship to mitosis as the previous fluctuation.

  6. Effectiveness and student perceptions of an active learning activity using a headline news story to enhance in-class learning of cell cycle regulation.

    PubMed

    Dirks-Naylor, Amie J

    2016-06-01

    An active learning activity was used to engage students and enhance in-class learning of cell cycle regulation in a PharmD level integrated biological sciences course. The aim of the present study was to determine the effectiveness and perception of the in-class activity. After completion of a lecture on the topic of cell cycle regulation, students completed a 10-question multiple-choice quiz before and after engaging in the activity. The activity involved reading of a headline news article published by ScienceDaily.com entitled "One Gene Lost Equals One limb Regained." The name of the gene was deleted from the article and, thus, the end goal of the activity was to determine the gene of interest by the description in the story. The activity included compiling a list of all potential gene candidates before sufficient information was given to identify the gene of interest (p21). A survey was completed to determine student perceptions of the activity. Quiz scores improved by an average of 20% after the activity (40.1 ± 1.95 vs. 59.9 ± 2.14,P< 0.0001,n= 96). Students enjoyed the activity, found the news article interesting, and believed that the activity improved their understanding of cell cycle regulation. The majority of students agreed that the in-class activity piqued their interest for learning the subject matter and also agreed that if they understand a concept during class, they are more likely to want to study that concept outside of class. In conclusion, the activity improved in-class understanding and enhanced interest in cell cycle regulation. PMID:27068993

  7. Symbolic Violence, Locality and Social Class: The Educational and Career Aspirations of 10-11-Year-Old Boys in Belfast

    ERIC Educational Resources Information Center

    Connolly, Paul; Healy, Julie

    2004-01-01

    This article is based upon a comparative, ethnographic case study of two groups of 10-11-year-old boys--one middle-class, the other working-class--living in Belfast. Drawing upon Bourdieu's related concepts of symbolic violence and habitus, it shows how locality can help to explain the very different educational and career aspirations found…

  8. Early Predictors of Language and Social Communication Impairments at Ages 9-11 Years: A Follow-up Study of Early-Referred Children

    ERIC Educational Resources Information Center

    Chiat, Shula; Roy, Penny

    2013-01-01

    Purpose: In this study, the authors aimed to evaluate hypotheses that early sociocognition will predict later social communication and early phonology will predict later morphosyntax in clinically referred preschoolers. Method: Participants were 108 children ages 9-11 years who had been referred to clinical services with concerns about language at…

  9. The Automated Self-Administered 24-Hour Dietary Recall for Children, 2012 version, for youth aged 9 to 11 Years: A validation study

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Our objective was to validate the 2012 version of the Automated Self-Administered 24-Hour Dietary Recall for Children (ASA24-Kids-2012), a self-administered web-based 24-hour dietary recall (24hDR) instrument, among children aged 9 to 11 years, in two sites using a quasiexperimental design. In one s...

  10. Validation of the automated self-administered 24-hour dietary recall for children (ASA24-Kids) among 9- to 11-year-old youth

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Our purpose was to validate ASA24-Kids-2012, a self-administered web-based 24-hour dietary recall (24hDR) among 9- to 11-year-old children. Sixty-nine children in two sites participated in the study. In one site, trained staff observed and recorded types and portions of foods and drinks consumed by ...

  11. The Reading Lives of 8 to 11-Year-Olds 2005-2013: An Evidence Paper for the Read On. Get On. Coalition

    ERIC Educational Resources Information Center

    Clark, Christina

    2014-01-01

    This report focuses on children aged 8 to 11 and their enjoyment of reading, reading behaviour, and attitudes toward reading. It synthesises information from surveys that have been conducted since 2005, but most heavily exploits data from the fourth annual literacy survey conducted in November/December 2013 in which 10,946 8 to 11-year-olds…

  12. Hospital admissions from birth to early adolescence and early-life risk factors: the 11-year follow-up of the 1993 Pelotas (Brazil) birth cohort study

    PubMed Central

    Menezes, Ana M. B.; Noal, Ricardo B.; Cesar, Juraci A.; Hallal, Pedro C.; Araújo, Cora Luiza; Dumith, Samuel C.; Barros, Fernando C.; Victora, Cesar G.

    2013-01-01

    The aim of this prospective analysis was to describe the cumulative incidence of hospital admissions in the first year of life and between 1 and 11 years of age and to explore associated factors. Hospital admissions were collected through regular monitoring in the first year of life, and through maternal report on admissions between 1 and 11 years. Analyses were stratified by sex and adjusted for confounding factors. 18.1% of children were hospitalized in the first year of life, and 30.7% between ages 1 and 11 years. Among boys, hospital admission in the first year was associated with low family income, paternal smoking during pregnancy, preterm delivery, and low birthweight. Among girls, in addition to the variables described for boys, black/mixed skin color was also a risk factor for hospital admission. For admissions between 1 and 11 years of age, low family income and gestational age ≥ 37 weeks were found to be significant risk factors. PMID:20963296

  13. Protecting the Development of 5-11-Year-Olds from the Impacts of Early Disadvantage: The Role of Primary School Academic Effectiveness

    ERIC Educational Resources Information Center

    Sammons, Pam; Hall, James; Sylva, Kathy; Melhuish, Edward; Siraj-Blatchford, Iram; Taggart, Brenda

    2013-01-01

    Whether or not more effective schools can successfully mitigate the impacts of early disadvantage upon educational attainment remains uncertain. We investigated 2,664 children aged 6-11 years and measured their academic skills in English and maths along with self-regulation at 6, 7, and 11. Experiencing multiple disadvantages before age 5 strongly…

  14. Mental Calculation Methods Used by 11-Year-Olds in Different Attainment Bands: A Reanalysis of Data from the 1987 APU Survey in the UK.

    ERIC Educational Resources Information Center

    Foxman, Derek; Beishuizen, Meindert

    2002-01-01

    Reanalyzes data obtained in 1987 on mental calculation strategies used by 11-year-olds in England, Wales, and Northern Ireland. Classifies mental strategies developed in the past decade in international research. Compares frequency and effectiveness of the strategies used by pupils of different levels of attainment. Discusses basic arithmetic…

  15. To Tan or Not to Tan?: Students Learn About Sunscreens through an Inquiry Activity Based on the Learning Cycle

    ERIC Educational Resources Information Center

    Keen-Rocha, Linda

    2005-01-01

    Science instructors sometimes avoid inquiry-based activities due to limited classroom time. Inquiry takes time, as students choose problems, design experiments, obtain materials, conduct investigations, gather data, communicate results, and discuss their experiments. While there are no quick solutions to time concerns, the 5E learning cycle seeks…

  16. Is there a difference in the electromyographic activity of the pelvic floor muscles across the phases of the menstrual cycle?

    PubMed Central

    Micussi, Maria Thereza; Freitas, Rodrigo Pegado; Angelo, Priscylla Helouyse; Soares, Elvira Maria; Lemos, Telma Maria; Maranhão, Técia Maria

    2015-01-01

    [Purpose] To evaluate the electrical activity of the pelvic floor muscle in women during the follicular, ovulatory, and luteal phases of the menstrual cycle and its correlation with estradiol and total testosterone levels. [Subjects and Methods] This cross-sectional study involved 30 women with ovulatory menstrual cycles. Total testosterone and estradiol levels were measured and the muscle tone and maximum voluntary contraction of the pelvic floor muscles were evaluated using surface electromyography. [Results] Muscle tone was significantly lower during the follicular (21.1±3.3 μV) and ovulatory (27.1±5.9 μV) phases than the luteal phase (30.4±4.1 μV). The maximum voluntary contraction was not different across phases. The estradiol level on the 7th day of the menstrual cycle showed a strong positive correlation with muscle tone and maximum voluntary contraction, and the testosterone level was positively correlated with muscle tone on the 21st day. [Conclusion] Women have better muscle tone during the luteal phase. The muscle tone and maximum voluntary contraction were strongly correlated with the estradiol level on the 7th day, and the muscle tone was correlated with the testosterone level on the 21st day of the menstrual cycle. These findings suggest that hormonal fluctuations during the menstrual cycle alter pelvic floor muscle activity. PMID:26311960

  17. Study of Quasi-Homologous Coronal Mass Ejections from Super Active Regions in Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Liu, L.; Wang, Y.; Shen, C.; Liu, R.; Ye, P.; Wang, S.

    2014-12-01

    Coronal Mass Ejections are most severe eruptive phenomenon in the solar atmosphere and are believed as the major energy source of the Near-Earth Space Environment. The study of CMEs is very important for the Space Weather forecast. The active regions , especially super-active regions, containing lots of magnetic free energy, are considered as the most important source regions of CMEs. Knowing why and how may some active regions (ARs) frequently produce CMEs is one of the key questions to deepen our understanding of the mechanisms and processes of energy accumulation and sudden release in ARs as well as improving our capability of space weather prediction. Based on above, we have done two parts of work: the first one is selecting all 37 SARs in the entire 23 solar cycle, using data provided by SOHO/LASCO C2|EIT|MDI, manually determining 285 CMEs produced by those SARs; second, we use the term 'quasi-homologous'to refer to successive CMEs originating from the same ARs within a short interval, analyze the rules of quasi-homologous CMEs' generation. Finally, we got two conclusions. 1. The waiting times of quasi-homologous CMEs have a two-component distribution with a separation at about 18 hours. The first component is a Gaussian-like distribution with a peak at about 7 hours, which indicates a tight physical connection between these quasi-homologous CMEs. The likelihood of occurrences of two or more CMEs faster than 1200 km /s from the same AR within 18 hours is about 20%. 2. The correlation analysis among CME waiting times, CME speeds and CME occurrence rates reveals that these quantities are independent to each other, suggesting that the perturbation by preceding CMEs rather than free energy input be the direct cause of quasi-homologous CMEs. The peak waiting time of 7 hours probably characterize the time scale of the growth of instabilities triggered by preceding CMEs. This study uncovers more clues from a statistical perspective for us to understand quasi

  18. Eicosapentaenoic Acid and Docosahexaenoic Acid in Whole Blood Are Differentially and Sex-Specifically Associated with Cardiometabolic Risk Markers in 8–11-Year-Old Danish Children

    PubMed Central

    Damsgaard, Camilla T.; Eidner, Maj B.; Stark, Ken D.; Hjorth, Mads F.; Sjödin, Anders; Andersen, Malene R.; Andersen, Rikke; Tetens, Inge; Astrup, Arne; Michaelsen, Kim F.; Lauritzen, Lotte

    2014-01-01

    n-3 long-chain polyunsaturated fatty acids improve cardiovascular risk markers in adults. These effects may differ between eicosapentaenoic acid (EPA, 20∶5n-3) and docosahexaenoic acid (DHA, 22∶6n-3), but we lack evidence in children. Using baseline data from the OPUS School Meal Study we 1) investigated associations between EPA and DHA in whole blood and early cardiometabolic risk markers in 713 children aged 8–11 years and 2) explored potential mediation through waist circumference and physical activity and potential dietary confounding. We collected data on parental education, pubertal stage, 7-day dietary records, physical activity by accelerometry and measured anthropometry, blood pressure, and heart rate. Blood samples were analyzed for whole blood fatty acid composition, cholesterols, triacylglycerol, insulin resistance by the homeostatic model of assessment (HOMA-IR), and inflammatory markers. Whole blood EPA was associated with a 2.7 mmHg (95% CI 0.4; 5.1) higher diastolic blood pressure per weight% EPA, but only in boys. Heart rate was negatively associated with both EPA and DHA status (P = 0.02 and P = 0.002, respectively). Whole blood EPA was negatively associated with triacylglycerol (P = 0.003) and positively with total cholesterol, low density and high density lipoprotein (HDL) cholesterol and HDL:triacylglycerol (all P<0.01) whereas DHA was negatively associated with insulin and HOMA-IR (P = 0.003) and tended to be negatively associated with a metabolic syndrome-score (P = 0.05). Adjustment for waist circumference and physical activity did not change the associations. The association between DHA and HOMA-IR was attenuated but remained after adjustment for fiber intake and none of the other associations were confounded by dietary fat, protein, fiber or energy intake. This study showed that EPA status was negatively associated with triacylglycerol and positively with cholesterols whereas DHA was negatively associated with

  19. Commercial Activated Carbon for the Catalytic Production of Hydrogen via the Sulfur-Iodine Thermochemical Water Splitting Cycle

    SciTech Connect

    Daniel M. Ginosar; Lucia M. Petkovic; Kyle C. Burch

    2011-07-01

    Eight activated carbon catalysts were examined for their catalytic activity to decompose hydroiodic acid (HI) to produce hydrogen; a key reaction in the sulfur-iodine (S-I) thermochemical water splitting cycle. Activity was examined under a temperature ramp from 473 to 773 K. No statistically significant correlation was found between catalyst sample properties and catalytic activity. Four of the eight samples were examined for one week of continuous operation at 723 K. All samples appeared to be stable over the period of examination.

  20. SOLAR CYCLE VARIATIONS OF THE OCCURRENCE OF CORONAL TYPE III RADIO BURSTS AND A NEW SOLAR ACTIVITY INDEX

    SciTech Connect

    Lobzin, Vasili; Cairns, Iver H.; Robinson, Peter A.

    2011-07-20

    This Letter presents the results of studies of solar cycle variations of the occurrence rate of coronal type III radio bursts. The radio spectra are provided by the Learmonth Solar Radio Observatory (Western Australia), part of the USAF Radio Solar Telescope Network (RSTN). It is found that the occurrence rate of type III bursts strongly correlates with solar activity. However, the profiles for the smoothed type III burst occurrence rate differ considerably from those for the sunspot number, 10.7 cm solar radio flux, and solar flare index. The type III burst occurrence rate (T3BOR) is proposed as a new index of solar activity. T3BOR provides complementary information about solar activity and should be useful in different studies including solar cycle predictions and searches for different periodicities in solar activity. This index can be estimated from daily results of the Automated Radio Burst Identification System. Access to data from other RSTN sites will allow processing 24 hr radio spectra in near-real time and estimating true daily values of this index. It is also shown that coronal type III bursts can even occur when there are no visible sunspots on the Sun. However, no evidence is found that the bursts are not associated with active regions. It is also concluded that the type III burst productivity of active regions exhibits solar cycle variations.

  1. The impacts of climate change and human activities on biogeochemical cycles on the Qinghai-Tibetan Plateau.

    PubMed

    Chen, Huai; Zhu, Qiuan; Peng, Changhui; Wu, Ning; Wang, Yanfen; Fang, Xiuqing; Gao, Yongheng; Zhu, Dan; Yang, Gang; Tian, Jianqing; Kang, Xiaoming; Piao, Shilong; Ouyang, Hua; Xiang, Wenhua; Luo, Zhibin; Jiang, Hong; Song, Xingzhang; Zhang, Yao; Yu, Guirui; Zhao, Xinquan; Gong, Peng; Yao, Tandong; Wu, Jianghua

    2013-10-01

    With a pace of about twice the observed rate of global warming, the temperature on the Qinghai-Tibetan Plateau (Earth's 'third pole') has increased by 0.2 °C per decade over the past 50 years, which results in significant permafrost thawing and glacier retreat. Our review suggested that warming enhanced net primary production and soil respiration, decreased methane (CH(4)) emissions from wetlands and increased CH(4) consumption of meadows, but might increase CH(4) emissions from lakes. Warming-induced permafrost thawing and glaciers melting would also result in substantial emission of old carbon dioxide (CO(2)) and CH(4). Nitrous oxide (N(2)O) emission was not stimulated by warming itself, but might be slightly enhanced by wetting. However, there are many uncertainties in such biogeochemical cycles under climate change. Human activities (e.g. grazing, land cover changes) further modified the biogeochemical cycles and amplified such uncertainties on the plateau. If the projected warming and wetting continues, the future biogeochemical cycles will be more complicated. So facing research in this field is an ongoing challenge of integrating field observations with process-based ecosystem models to predict the impacts of future climate change and human activities at various temporal and spatial scales. To reduce the uncertainties and to improve the precision of the predictions of the impacts of climate change and human activities on biogeochemical cycles, efforts should focus on conducting more field observation studies, integrating data within improved models, and developing new knowledge about coupling among carbon, nitrogen, and phosphorus biogeochemical cycles as well as about the role of microbes in these cycles. PMID:23744573

  2. Unusual Polar Activity of the Sun in the Northern Hemisphere and Its Implications for Solar Cycle 25

    NASA Astrophysics Data System (ADS)

    Gopalswamy, Nat; Masuda, Satoshi; Yashiro, Seiji; Akiyama, Sachiko; Shibasaki, Kiyoto

    2016-07-01

    Polar field strength in one solar cycle is known to indicate the strength (e.g., Sunspot number) and phase of the next cycle. In particular the polar field strength (or its proxies such as the polar coronal hole area and microwave polar brightness) during the minimum phase of a given cycle seem to be well correlated with the maximum sunspot number of the next cycle. Polar prominence eruptions and coronal mass ejections have also been found to be indicators of low polar field; their cessation signals the time of polarity reversal. While these indicators are present in the current cycle, significant differences are found regarding the phase lag between the two hemispheres and the duration of polar eruptions. We use data from the Nobeyama Radioheliograph, the Solar Dynamics Observatory, SOLIS, and Wilcox Solar Observatory to highlight these differences. We find that the north polar region of the Sun has near-zero field strength for more than three years. This is unusually long and caused by surges of both polarities heading toward the north pole that prevent the buildup of the polar field. This seems to be due to anti-Hale active regions that appeared around the 2012 peak sunspot activity in the northern hemisphere. The unusual condition is consistent with (i) the continued high-latitude prominence eruption, (ii) the extended period of high tilt angle of the heliospheric current sheet, (iii) the weak microwave polar brightness, and (iv) the lack of north polar coronal hole. On the other hand, the south polar field has started building up and the coronal hole has appeared in early 2015 because of large active regions of the correct tilt in the southern hemisphere during the 2014 peak of sunspot activity. The extended period of near-zero field in the north polar region should result in very weak and delayed sunspot activity in the northern hemisphere in cycle 25. On the other hand the south polar field has already increased significantly, suggesting that the activity in

  3. Environmental impact associated with activated carbon preparation from olive-waste cake via life cycle assessment.

    PubMed

    Hjaila, K; Baccar, R; Sarrà, M; Gasol, C M; Blánquez, P

    2013-11-30

    The life cycle assessment (LCA) environmental tool was implemented to quantify the potential environmental impacts associated with the activated carbon (AC) production process from olive-waste cakes in Tunisia. On the basis of laboratory investigations for AC preparation, a flowchart was developed and the environmental impacts were determined. The LCA functional unit chosen was the production of 1 kg of AC from by-product olive-waste cakes. The results showed that impregnation using H3PO4 presented the highest environmental impacts for the majority of the indicators tested: acidification potential (62%), eutrophication (96%), ozone depletion potential (44%), human toxicity (64%), fresh water aquatic ecotoxicity (90%) and terrestrial ecotoxicity (92%). One of the highest impacts was found to be the global warming potential (11.096 kg CO2 eq/kg AC), which was equally weighted between the steps involving impregnation, pyrolysis, and drying the washed AC. The cumulative energy demand of the AC production process from the by-product olive-waste cakes was 167.63 MJ contributed by impregnation, pyrolysis, and drying the washed AC steps. The use of phosphoric acid and electricity in the AC production were the main factors responsible for the majority of the impacts. If certain modifications are incorporated into the AC production, such as implementing synthesis gas recovery and reusing it as an energy source and recovery of phosphoric acid after AC washing, additional savings could be realized, and environmental impacts could be minimized. PMID:24091159

  4. Real-Time Patient Survey Data During Routine Clinical Activities for Rapid-Cycle Quality Improvement

    PubMed Central

    Jones, Robert E

    2015-01-01

    Background Surveying patients is increasingly important for evaluating and improving health care delivery, but practical survey strategies during routine care activities have not been available. Objective We examined the feasibility of conducting routine patient surveys in a primary care clinic using commercially available technology (Web-based survey creation, deployment on tablet computers, cloud-based management of survey data) to expedite and enhance several steps in data collection and management for rapid quality improvement cycles. Methods We used a Web-based data management tool (survey creation, deployment on tablet computers, real-time data accumulation and display of survey results) to conduct four patient surveys during routine clinic sessions over a one-month period. Each survey consisted of three questions and focused on a specific patient care domain (dental care, waiting room experience, care access/continuity, Internet connectivity). Results Of the 727 available patients during clinic survey days, 316 patients (43.4%) attempted the survey, and 293 (40.3%) completed the survey. For the four 3-question surveys, the average time per survey was overall 40.4 seconds, with a range of 5.4 to 20.3 seconds for individual questions. Yes/No questions took less time than multiple choice questions (average 9.6 seconds versus 14.0). Average response time showed no clear pattern by order of questions or by proctor strategy, but monotonically increased with number of words in the question (<20 words, 21-30 words, >30 words)—8.0, 11.8, 16.8, seconds, respectively. Conclusions This technology-enabled data management system helped capture patient opinions, accelerate turnaround of survey data, with minimal impact on a busy primary care clinic. This new model of patient survey data management is feasible and sustainable in a busy office setting, supports and engages clinicians in the quality improvement process, and harmonizes with the vision of a learning health

  5. Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow.

    PubMed

    Zhou, Jing; Lee, Pei-Ling; Tsai, Chien-Sung; Lee, Chih-I; Yang, Tung-Lin; Chuang, Han-Sheng; Lin, Wei-Wen; Lin, Ting-Er; Lim, Seh Hong; Wei, Shu-Yi; Chen, Yuh-Lien; Chien, Shu; Chiu, Jeng-Jiann

    2012-05-15

    Vascular endothelial cells (ECs) are constantly exposed to blood flow-induced shear stress, but the mechanism of force-specific activation of their signaling to modulate cellular function remains unclear. We have demonstrated that bone morphogenetic protein receptor (BMPR)-specific Smad1/5 can be force-specifically activated by oscillatory shear stress (OSS) in ECs to cause cell cycle progression. Smad1/5 is highly activated in ECs of atherosclerotic lesions in diseased human coronary arteries from patients with end-stage heart failure undergoing heart transplantation and from apolipoprotein E-deficient mice. Application of OSS (0.5 ± 4 dyn/cm(2)) causes the sustained activation of Smad1/5 in ECs through activations of mammalian target of rapamycin and p70S6 kinase, leading to up-regulation of cyclin A and down-regulations of p21(CIP1) and p27(KIP1) and, hence, EC cycle progression. En face examination of rat aortas reveals high levels of phospho-Smad1/5 in ECs of the inner, but not the outer, curvature of aortic arch, nor the straight segment of thoracic aorta [corrected]. Immunohistochemical and en face examinations of the experimentally stenosed abdominal aorta in rats show high levels of phospho-Smad1/5 in ECs at poststenotic sites, where OSS occurs. These OSS activations of EC Smad1/5 in vitro and in vivo are not inhibited by the BMP-specific antagonist Noggin and, hence, are independent of BMP ligand. Transfecting ECs with Smad1/5-specific small interfering RNAs inhibits the OSS-induced EC cycle progression. Our findings demonstrate the force-specificity of the activation of Smad1/5 and its contribution to cell cycle progression in ECs induced by disturbed flow. PMID:22550179

  6. The Effects of Playground Markings on the Physical Self-Perceptions of 10-11-Year-Old School Children

    ERIC Educational Resources Information Center

    Crust, Lee; McKenna, Jim; Spence, Jon; Thomas, Catherine; Evans, Donna; Bishop, Daniel

    2014-01-01

    Background: Significant proportions of school children in the UK do not meet the minimum recommended daily requirements of 60-min moderate-intensity physical activity. Beyond taught classes, playtimes offer the opportunity for children to play and be physically active. Painted markings are one recent addition to school playgrounds that are…

  7. Isotopic Identification of Nitrate Sources and Cycling in Arctic Tundra Active Layer Soils and Permafrost

    NASA Astrophysics Data System (ADS)

    Heikoop, J. M.; Throckmorton, H.; Newman, B. D.; Perkins, G.; Gard, M.; Iversen, C. M.; Wilson, C. J.; Wullschleger, S. D.

    2014-12-01

    The effect of nitrogen cycling on release of carbon from tundra ecosystems is being studied as part of the US Department of Energy Next Generation Ecosystem Experiment - Arctic project. Sampling and analysis of active layer soil water at the Barrow Environmental Observatory (Alaska, USA) was performed in ancient drained thaw lake basins (DTLBs), drainages, and in polygonal terrain associated with inter-DTLB tundra. Within active layer soils, nitrate was most commonly found above analytical limits of detection in pore water from the unsaturated centers of high-centered polygons. Nitrate has also been detected, though less frequently, in soil water immediately above the frost table of an ancient (14C age of 2000 - 5500 BP) DTLB and in a small drainage adjacent to high-centered polygonal terrain. Nitrate from high-centered polygons had δ15N ranging from -9.2 to +8.5 ‰ and δ18O ranging from -8.4 to +1.4 ‰. The δ15N isotopic range is consistent with microbial mineralization and nitrification of reduced nitrogen sources including ammonium, dissolved organic nitrogen, and soil organic nitrogen. The range in δ18O of nitrate is also consistent with nitrification based on the δ18O of site waters. No evidence for an atmospheric nitrate signal, as defined by δ15N and δ18O of nitrate in snow and snowmelt, is seen. In contrast, nitrate in permafrost appears to be a mixture of pre-industrial atmospheric nitrate (with higher δ15N than modern atmospheric nitrate) and nitrate that is microbial in origin. Massive ice wedges appear to contain larger proportions of snowmelt (based on δ18O of ice) and atmospheric nitrate, whereas textural ice appears to contain a greater proportion of summer precipitation and microbially-derived nitrate. Nitrate from the ancient DTLB and drainage samples also has isotopic signatures that appear to represent a mixture of pre-industrial atmospheric nitrate and nitrate from microbial nitrification, and may, at least in part, be derived from

  8. Anthropometric Characteristics, Physical Fitness and Motor Coordination of 9 to 11 Year Old Children Participating in a Wide Range of Sports

    PubMed Central

    Elferink-Gemser, Marije; Hartman, Esther; Willemse, Bas; Philippaerts, Renaat; Visscher, Chris; Lenoir, Matthieu

    2015-01-01

    Objectives The aim of this study was to investigate to what extent 9 to 11 year old children participating in a specific sport already exhibit a specific anthropometric, physical fitness and motor coordination profile, in line with the requirements of that particular sport. In addition, the profiles in children with a different training volume were compared and possible differences in training hours per week between children from a low, moderate, and high level of physical fitness and motor coordination were investigated. Methods and Results Data of 620 children, 347 boys and 273 girls, who participated in the Flemish Sports Compass were used. Only the primary sport of each child was considered and six groups of sports (Ball sports, Dance, Gymnastics, Martial arts, Racquet sports and Swimming) were formed based on common characteristics. Measurements consisted of 17 tests. Independent T-tests and Mann-Whitney U-tests revealed few differences between the groups of sports and the discriminant analyses with the moderate and low active group did not show any significant results (p > .05). However, when discriminating among the high active children, a 85.2 % correct classification between six groups of sports was found (Wilks’ Λ = .137 and p < .001). Finally, children performing under average on the tests spent significantly fewer hours in sport per week (2.50 ± 1.84 hours) compared to the children performing best (3.25 ± 2.60 hours) (p = .016) and the children performing above average (2.90 ± 1.96 hours) (p = .029) on physical fitness and motor coordination. Discussion The study showed that in general, children at a young age do not exhibit sport-specific characteristics, except in children with a high training volume. It is possible that on the one hand, children have not spent enough time yet in their sport to develop sport-specific qualities. On the other hand, it could be possible that they do not take individual qualities into account when choosing a sport

  9. Cumulative high doses of inhaled formoterol have less systemic effects in asthmatic children 6–11 years-old than cumulative high doses of inhaled terbutaline

    PubMed Central

    Kaae, Rikke; Agertoft, Lone; Pedersen, Sören; Nordvall, S Lennart; Pedroletti, Christophe; Bengtsson, Thomas; Johannes-Hellberg, Ingegerd; Rosenborg, Johan

    2004-01-01

    Objectives To evaluate high dose tolerability and relative systemic dose potency between inhaled clinically equipotent dose increments of formoterol and terbutaline in children. Methods Twenty boys and girls (6–11 years-old) with asthma and normal ECGs were studied. Ten doses of formoterol (Oxis®) 4.5 µg (F4.5) or terbutaline (Bricanyl®) 500 µg (T500) were inhaled cumulatively via a dry powder inhaler (Turbuhaler®) over 1 h (three patients) or 2.5 h (17 patients) and compared to a day of no treatment, in a randomised, double-blind (active treatments only), crossover trial. Blood pressure (BP), ECG, plasma potassium, glucose, lactate, and adverse events were monitored up to 10 h to assess tolerability and relative systemic dose potency. Results Formoterol and terbutaline had significant β2-adrenergic effects on most outcomes. Apart from the effect on systolic BP, QRS duration and PR interval, the systemic effects were significantly more pronounced with terbutaline than with formoterol. Thus, mean minimum plasma potassium, was suppressed from 3.56 (95% confidence interval, CI: 3.48–3.65) mmol l−1 on the day of no treatment to 2.98 (CI: 2.90–3.08) after 10 × F4.5 and 2.70 (CI: 2.61–2.78) mmol l−1 after 10 × T500, and maximum Q-Tc (heart rate corrected Q-T interval [Bazett's formula]) was prolonged from 429 (CI: 422–435) ms on the day of no treatment, to 455 (CI: 448–462) ms after 10 × F4.5 and 470 (CI: 463–476) ms after 10 × T500. Estimates of relative dose potency indicated that F4.5 µg had the same systemic activity as the clinically less effective dose of 250 µg terbutaline. The duration of systemic effects differed marginally between treatments. Spontaneously reported adverse events (most frequently tremor) were fewer with formoterol (78% of the children) than with terbutaline (95%). A serious adverse event occurred after inhalation of 45 µg formoterol over the 1 h dosing time, that prompted the extension of dosing time to 2.5 h

  10. Deciphering solar magnetic activity. I. On the relationship between the sunspot cycle and the evolution of small magnetic features

    SciTech Connect

    McIntosh, Scott W.; Wang, Xin; Markel, Robert S.; Thompson, Michael J.; Leamon, Robert J.; Malanushenko, Anna V.; Davey, Alisdair R.; Howe, Rachel; Krista, Larisza D.; Cirtain, Jonathan W.; Gurman, Joseph B.; Pesnell, William D.

    2014-09-01

    Sunspots are a canonical marker of the Sun's internal magnetic field which flips polarity every ∼22 yr. The principal variation of sunspots, an ∼11 yr variation, modulates the amount of the magnetic field that pierces the solar surface and drives significant variations in our star's radiative, particulate, and eruptive output over that period. This paper presents observations from the Solar and Heliospheric Observatory and Solar Dynamics Observatory indicating that the 11 yr sunspot variation is intrinsically tied to the spatio-temporal overlap of the activity bands belonging to the 22 yr magnetic activity cycle. Using a systematic analysis of ubiquitous coronal brightpoints and the magnetic scale on which they appear to form, we show that the landmarks of sunspot cycle 23 can be explained by considering the evolution and interaction of the overlapping activity bands of the longer-scale variability.

  11. Inhibition of protein kinase B activity induces cell cycle arrest and apoptosis during early G₁ phase in CHO cells.

    PubMed

    van Opstal, Angélique; Bijvelt, José; van Donselaar, Elly; Humbel, Bruno M; Boonstra, Johannes

    2012-04-01

    Inhibition of PKB (protein kinase B) activity using a highly selective PKB inhibitor resulted in inhibition of cell cycle progression only if cells were in early G1 phase at the time of addition of the inhibitor, as demonstrated by time-lapse cinematography. Addition of the inhibitor during mitosis up to 2 h after mitosis resulted in arrest of the cells in early G1 phase, as deduced from the expression of cyclins D and A and incorporation of thymidine. After 24 h of cell cycle arrest, cells expressed the cleaved caspase-3, a central mediator of apoptosis. These results demonstrate that PKB activity in early G1 phase is required to prevent the induction of apoptosis. Using antibodies, it was demonstrated that active PKB translocates to the nucleus during early G1 phase, while an even distribution of PKB was observed through cytoplasm and nucleus during the end of G1 phase. PMID:22251027

  12. The magnetic activity cycle of II Pegasi: results from twenty-five year