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Sample records for 11th grade high

  1. The Effects of Cardio-Syntactic Analysis Instruction on Writing Scores in a 11th Grade High School Classroom

    ERIC Educational Resources Information Center

    Kariuki, Patrick N.; Blair, Paul W.

    2015-01-01

    The purpose of this research was to determine the effects of Cardio-Syntactic Analysis instruction on writing scores in an 11th grade English class. The sample consisted of 35 students enrolled in an Honor's English 11 class at Volunteer high School, in Church Hill, TN. The class was randomly assigned into an experimental group of 17 students and…

  2. Evaluation of 11th Grade Students' Cognitive Behaviour on Some Subjects of Analysis According to Gender

    ERIC Educational Resources Information Center

    Nevin, Orhun

    2005-01-01

    The purpose of this research is to investigate students' cognitive behaviour in the subjects of function, limit, and derivative according to gender. The research was conducted with the participation of 67 female and 58 male 11th grade students of Gazi High School in Eskisehir in the academic year 2000/2001. The data were obtained through a test…

  3. Work Values of 5th, 8th, and 11th Grade Students

    ERIC Educational Resources Information Center

    Hales, Loyde W.; Fenner, Bradford

    1972-01-01

    Self Realization, Job Security, Money, and Altruism were found to be the most important work values, with 5th and 8th grade students differing from 11th grade students on Altruism and Self Realization. (Author)

  4. The Minnesota 11th and 12th Grade Post-Secondary Enrollment Options Program: Is It Changing the Traditional Structure of Secondary and Post-Secondary Schools?

    ERIC Educational Resources Information Center

    Boughton, Roger W.

    In 1985, the Minnesota Legislature passed legislation permitting and encouraging 11th and 12th grade students attending public high schools to enroll in public and private postsecondary institutions. Approximately 2% of all 11th and 12th grade students in the state took part in the program during its first year of operation, with the majority of…

  5. Indiana's Academic Standards: 11th Grade English/Language Arts.

    ERIC Educational Resources Information Center

    Indiana State Dept. of Education, Indianapolis.

    This booklet of academic standards spells out what students should know and be able to do in Grade 11 English/Language Arts. The booklet gives examples to help students understand what is required to meet the standards and provides a list of 10 things parents can do to help their child get a good education. It outlines the following seven…

  6. Vocational Agriculture III. A Curriculum Guide, 11th Grade.

    ERIC Educational Resources Information Center

    Patton, Bob; Cox, Cecil

    Designed to provide a basic core of instruction for the third year of agriculture in Oklahoma, this guide is for use by teachers and their eleventh grade students. Instructional content is in five sections, each with four or more units: soil science, leadership, animal science, farm business management, and agricultural mechanics. Each unit…

  7. Emotional Intelligence as a Predictor of Leadership of Kuwaiti High and Low Achieving 11th Graders

    ERIC Educational Resources Information Center

    Alnabhan, Mousa

    2010-01-01

    The current study examined the association between emotional intelligence (EI) and the Leadership components (L) of high school students in the state of Kuwait. The possibility of predicting each leadership component via emotional intelligence components was investigated for high and low achievers. A sample of 11th grade students from Kuwaiti…

  8. Improving Instruction, Motivation, and Writing Skills To Foster Content Mastery among 11th Grade Chemistry Students.

    ERIC Educational Resources Information Center

    Litteral, Diana B.

    This practicum was designed to increase concept mastery of 11th grade chemistry students by improving instruction, motivation, and writing skills. The problem addressed was that many chemistry students, perform well in group learning situations, such as labs, but perform poorly on content-mastery tests. As a result of reviewing the literature, the…

  9. Expertise, Argumentation and Scientific Practice: A Case Study about Environmental Education in the 11th Grade.

    ERIC Educational Resources Information Center

    Jimenez Alexandre, Maria Pilar; Pereiro Munoz, Cristina; Aznar Cuadrado, Virginia

    This paper reports a case study about argumentation and scientific practice in the 11th grade. The objectives of the study are to identify argument patterns and dimensions of the scientific practice in students' conversations and actions while engaged in an environmental management project in a wetland. The focus are the warrants that students…

  10. Investigating Community Factors as Predictors of Rural 11th-Grade Agricultural Science Students' Choice of Careers in Agriculture

    ERIC Educational Resources Information Center

    Adedokun, Omolola A.; Balschweid, Mark A.

    2008-01-01

    This study investigates the links between community contexts/factors and rural 11th-grade agricultural science students' choice of careers in agriculture. A logistic regression model was developed and tested to examine the extent to which nine measures of community contexts (i.e., membership in FFA, membership in 4-H, community attachment,…

  11. A Study of Grade Level and Gender Differences in Divergent Thinking among 8th and 11th Graders in a Mid-Western School District

    NASA Astrophysics Data System (ADS)

    Roue, Leah Christine

    This research study compared gender and grade level differences in divergent thinking among middle school and high school students in the Midwest, in an attempt to determine whether gender or grade level-based differences exist in divergent thinking. The instrument used was based on the Wallach and Kogan Creativity Test (WKCT). There were 166 public school students in the study from the 8th and 11th grades. The results were analyzed in an effort to answer two research questions: Are there gender differences in fluency, flexibility, or originality of a response? Are there grade level (age) differences in fluency, flexibility, or originality of a response? Quantitative and qualitative reporting is used.

  12. 11th Grade Students' Conceptual Understanding about Torque Concept: A Longitudinal Study

    ERIC Educational Resources Information Center

    Bostan Sarioglan, Ayberk; Küçüközer, Hüseyin

    2014-01-01

    In this study, it is aimed to reveal the effect of instruction on students' ideas about torque before instruction, after instruction and fifteen weeks after instruction. The working group consists of twenty five high school eleventh grade students. To reveal these students' ideas about the concept of torque a concept test consisting of seven…

  13. Nebraska Vocational Agribusiness Curriculum for City Schools. Horticulture. Agricultural Mechanics. A Curriculum Guide. 11th Grade.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Dept. of Agricultural Education.

    Designed for use with high school juniors, this agribusiness curriculum for city schools contains thirty-two units of instruction in the areas of horticulture and agricultural mechanics. Among the units included in the curriculum are (1) Planting Media, (2) Fertilizer, (3) Plant Classification, (4) Turf Grass Management, (5) Landscape Design, (6)…

  14. Using Guided Notes to Increase the Understanding of Anatomy and Physiology in 11th Grade Science Students

    NASA Astrophysics Data System (ADS)

    Mariano, Jay

    A survey of over 500 science teachers reported that two thirds of their science classes were lecture based lessons where students were required to listen and take notes (Boyle, 2010). In addition to taking notes from lectures, note taking is a necessary skill to possess to record scientific observations and procedures and record information during class. Guided notes is a pedagogical method in which the instructor prepares and provides students with a modified form of lecture information to guide students (Neef, McCord, & Ferreri, 2006). This study examined the extent to which the use of guided notes in a unit of study of the muscular system of anatomy and physiology positively affected the mastery on content-based assessments for 11 th grade students. The data collection methods included quiz and test scores, a 4-point Likert scale survey, and an open-ended questionnaire. Results of the data revealed that guided notes was one factor that led to mastery in learning content. Additionally, students in this study preferred this method as it helped them to distinguish relevant information allowing more time to listen and focus on the teacher.

  15. The Advanced Program of Vocational Agriculture in Louisiana. Ag III and Ag IV (11th and 12th Grades). Volume II. Bulletin No. 1725.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Div. of Vocational Education.

    This curriculum guide consists of materials for use in teaching an advanced course in agricultural mechanics designed for 11th and 12th grade students. Addressed in the individual units of the guide are arc welding; oxy-acetylene welding; soldering; electricity; tractor maintenance, operation, and safety; small engines; farm structures; and cold…

  16. An Assessment of 4th, 8th, and 11th Grade Students' Knowledge Related to Marine Science and Natural Resource Issues.

    ERIC Educational Resources Information Center

    Brody, Michael J.; Koch, Helmut

    In an effort to contribute information for science teachers and curriculum developers in Maine, this study generated base line data on 4th, 8th, and 11th grade students' knowledge of marine science and natural resources principles in relation to the Gulf of Maine. Five concept maps representing 15 major content principles were developed. Two…

  17. The impact of teacher assigned but not graded compared to teacher assigned and graded chemistry homework on the formative and summative chemistry assessment scores of 11th-grade students with varying chemistry potential

    NASA Astrophysics Data System (ADS)

    Wilson, Jennifer L.

    The study analyzed 2005 posttest data compared to 2008 posttest data to determine student end of school year academic achievement outcomes across three academic levels (above average, average, and below average chemistry potential) and two teacher homework evaluation methods (assigned but not graded and assigned and graded) on teacher prepared 11th-grade assessments, district prepared 11th-grade assessment, and district graduation requirement physical science strand 11th-grade science Essential Learner Outcome assessment. Overall, results indicated that students with above average (n = 16), average, (n = 17) and below average (n = 14) chemistry potential whom were given teacher assigned and graded chemistry homework compared to students with above average (n = 17), average (n = 15), and below average (n = 19) chemistry potential whom were given teacher assigned but not graded chemistry homework had statistically significantly higher independent t test matter homework scores while atoms, naming, and reactions homework scores were generally in the direction of higher but not significant scores for students given graded homework regardless of their chemistry potential. Furthermore, students of above average and below average chemistry potential who were given assigned and graded chemistry homework performed statistically significantly better on the 11th-grade district prepared chemistry final and the district prepared physical science strand Essential Learner Outcome assessment t test results compared to students with the same chemistry potential given assigned but not graded chemistry homework, suggesting that the graded chemistry condition may have contributed to improved long term learning and retention of chemistry knowledge. Finally, the coefficient of determination (r2 = .95) measure of strength of relationship between not completing, not graded chemistry homework and a corresponding drop in chemistry assessment scores for all students was 95% and the

  18. EDITORIAL: Special issue featuring articles arising from the 11th High-Tech Plasma Processes Conference Special issue featuring articles arising from the 11th High-Tech Plasma Processes Conference

    NASA Astrophysics Data System (ADS)

    Bruggeman, Peter; Degrez, Gérard; Delplancke, Marie-Paule; Gleizes, Alain

    2011-05-01

    The 11th High-Tech Plasma Processes Conference (HTPP) was held in Brussels, Belgium, 27 June-2 July, 2010. HTPP started as a thermal plasma conference and gradually expanded to include low-temperature plasmas. The conference was founded by Jacques Amouroux and Pierre Fauchais, and aims to bring together different scientific communities to facilitate contacts between science, technology and industry, providing a platform for the exploration of elementary processes and applications in and by plasmas. The first HTPP was held in Odeillo, France, in 1990. Since then it has been held every other year in different European cities: Paris, Aachen, Athens, Strasbourg, Saint-Petersburg, Patras and Brussels. The 11th HTPP conference was attended by 125 participants from 19 countries. The program involved 14 invited talks, 34 contributed talks, 72 posters and a software demonstration and hands-on session for plasma modelling. The 12th HTPP conference will be held 24-28 June 2012, in Bologna, Italy. A larger part of the contributions to the 11th HTPP has been published in the Journal of Physics: Conference Series (JPCS) volume 275, 2011. All invited speakers and other contributors, as selected by the Steering, Scientific and Organizing Committee, were invited to submit a paper based on their contributions for this special issue which is peer reviewed by the journal. Both this special issue and the JPCS volume aim to bring the 11th HTPP to a wider audience. The publications are a nice example of the broad topic range of the conference. The JPCS volume contains papers covering fundamental aspects on radiative processes of thermal plasmas, modelling of thermal arcs and non-thermal RF plasma jets, plasma diagnostics including flow and heat flux measurements of thermal plasmas, radical density measurements and laser-induced breakdown spectroscopy. The applications-oriented contributions of the JPCS volume include plasma spraying, synthesis of (nano-sized) materials, surface

  19. A Study of Effect of Dramatic Activities on Improving English Communicative Speaking Skill of Grade 11th Students

    ERIC Educational Resources Information Center

    Iamsaard, Prisana; Kerdpol, Sakon

    2015-01-01

    This paper aimed to reexamine the current EFL communicative speaking skill in high school level in Thailand due to the coming of the entry to ASEAN at the end of the year 2015. Thai students need to be well prepared for workforce in the future since English is used as the working language in ASEAN. The purposes of this paper were to study the…

  20. Nebraska Vocational Agribusiness Curriculum Guide for City Schools. Agricultural Processing. Companion Animals. A Curriculum Guide. 11th Grade.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Dept. of Agricultural Education.

    Designed for use with high school juniors, this agribusiness curriculum for city schools contains twenty-four units of instruction in the areas of agricultural processing and companion animals. Among the units included in the curriculum are (1) The Meat Processing Industry, (2) Retail Cuts of Meat, (3) Buying Meat and Portion Control, (4) Dairy…

  1. Nebraska Vocational Agribusiness Curriculum for City Schools. Production Agriculture. Natural Resources. A Curriculum Guide. 11th Grade.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Dept. of Agricultural Education.

    Designed for use with high school juniors, this agribusiness curriculum for city schools contains thirty-two units of instruction in the areas of production agriculture and natural resources. Among the units included are (1) Livestock Selection, (2) Animal Digestion, (3) Livestock Diseases, (4) Soil Conservation Practices, (5) Fertilizers, (6)…

  2. Homestead and Gardening Skills. A Guide for Providing Instruction for 11th and 12th Grade Students Enrolled in North Carolina's Secondary Schools [and] Vocational Education Competency Test-Item Bank. Agricultural Education.

    ERIC Educational Resources Information Center

    Robinson, Ward R.

    This document consists of a teacher's guide for a competency-based course on homestead and gardening skills designed for North Carolina's 11th- and 12th-grade students, and a list of competency test items applicable to the course. The teacher's guide contains course specifications, a list of competency statements, a sheet describing each unit of…

  3. Your Reading: An Annotated Booklist for Middle School and Junior High. 11th Edition. NCTE Bibliography Series.

    ERIC Educational Resources Information Center

    Brown, Jean E., Ed.; Stephens, Elaine C., Ed.

    Organized around the theme of "challenges," the 11th edition of "Your Reading" offers annotations of more than 1,200 books for young adults. Intended for teachers, librarians, parents, and students, this booklist presents recently published books that can be read for many purposes--for sheer enjoyment of the story, to pique curiosity or satisfy…

  4. A Study of Grade Level and Gender Differences in Divergent Thinking among 8th and 11th Graders in a Mid-Western School District

    ERIC Educational Resources Information Center

    Roue, Leah Christine

    2011-01-01

    This research study compared gender and grade level differences in divergent thinking among middle school and high school students in the Midwest, in an attempt to determine whether gender or grade level-based differences exist in divergent thinking. The instrument used was based on the Wallach and Kogan Creativity Test (WKCT). There were 166…

  5. An Assessment of 4th-, 8th-, and 11th-Grade Students' Environmental Science Knowledge Related to Oregon's Marine Resources.

    ERIC Educational Resources Information Center

    Brody, Michael J.

    1996-01-01

    Assesses the understanding that a sample of Oregon public school students (n=159) had of geology, physical and chemical characteristics, ecology, and natural resources as related to a marine environment. Results indicate that student understanding in some areas does not progress beyond the early grades and that the interdisciplinary approach of…

  6. Impact of National Board Certification, Advanced Degree, and Socio-Economic Status on the Literacy Achievement Rate of 11th Grade Students in Arkansas

    ERIC Educational Resources Information Center

    McCullough, Merlina Tamara

    2011-01-01

    The researcher explored whether there was a significant difference between the literacy achievement rates among eleventh grade students taught by National Board Certified Teachers versus students taught by non-National Board Certified Teachers with or without advanced degrees and of varied socio-economic levels. The researcher also explored the…

  7. Changes in the regional prevalence of child obesity in 4th, 8th, and 11th grade students in Texas from 2000-2002 to 2004-2005.

    PubMed

    Hoelscher, Deanna M; Kelder, Steven H; Pérez, Adriana; Day, R Sue; Benoit, Julia S; Frankowski, Ralph F; Walker, Joey L; Lee, Eun S

    2010-07-01

    Although national and state estimates of child obesity are available, data at these levels are insufficient to monitor effects of local obesity prevention initiatives. The purpose of this study was to examine regional changes in the prevalence of obesity due to statewide policies and programs among children in grades 4, 8, and 11 in Texas Health Services Regions (HSRs) between 2000-2002 and 2004-2005, and nine selected counties in 2004-2005. A cross-sectional, probability-based sample of 23,190 Texas students in grades 4, 8, and 11 were weighed and measured to obtain BMI. Obesity was >95th percentile for BMI by age/sex using Centers for Disease Control and Prevention growth charts. Child obesity prevalence significantly decreased between 2000-2002 and 2004-2005 for 4th grade students in the El Paso HSR (-7.0%, P = 0.005). A leveling off in the prevalence of obesity was noted for all other regions for grades 4, 8, and 11. County-level data supported the statistically significant decreases noted in the El Paso region. The reduction of child obesity levels observed in the El Paso area is one of the few examples of effective programs and policies based on a population-wide survey: in this region, a local foundation funded extensive regional implementation of community programs for obesity prevention, including an evidence-based elementary school-based health promotion program, adult nutrition and physical activity programs, and a radio and television advertising campaign. Results emphasize the need for sustained school, community, and policy efforts, and that these efforts can result in decreases in child obesity at the population level. PMID:19798066

  8. The Impact of Teacher Assigned but Not Graded Compared to Teacher Assigned and Graded Chemistry Homework on the Formative and Summative Chemistry Assessment Scores of 11th-Grade Students with Varying Chemistry Potential

    ERIC Educational Resources Information Center

    Wilson, Jennifer L.

    2010-01-01

    The study analyzed 2005 posttest data compared to 2008 posttest data to determine student end of school year academic achievement outcomes across three academic levels (above average, average, and below average chemistry potential) and two teacher homework evaluation methods (assigned but not graded and assigned and graded) on teacher prepared…

  9. US-Japan workshop on field-reversed configurations with steady-state high-temperature fusion plasmas and the 11th US-Japan workshop on compact toroids

    SciTech Connect

    Barnes, D.C.; Fernandez, J.C.; Rej, D.J.

    1990-05-01

    The US-Japan Workshop on Field-Reversed Configurations with Steady-State High-Temperature Fusion Plasma and the 11th US-Japan Workshop on Compact Toroids were held at Los Alamos National Laboratory, Los Alamos, New Mexico on November 7--9, 1989. These proceedings contain the papers presented at the workshops as submitted by the authors. These papers have been indexed separately.

  10. "You Think for Me, so I Don't Have To." The Effect of a Technology-Enhanced, Inquiry Learning Environment on Student Learning in 11th-Grade United States History

    ERIC Educational Resources Information Center

    Friedman, Adam M.; Heafner, Tina L.

    2007-01-01

    In a study investigating the effects of student engagement in inquiry learning through the development of Web sites, nearly every student reported having enjoyed the project, and the majority scored an A or B for their project grade. However, neither enjoyment nor high achievement on this performance task necessarily translated into high scores on…

  11. 11th Annual Legislative Summit, 2008

    ERIC Educational Resources Information Center

    National Indian Education Association, 2008

    2008-01-01

    Several papers were presented during the 11th Annual National Indian Education Association (NIEA) Legislative Summit. This volume contains the following briefing papers presented during the summit: (1) Reauthorization of No Child Left Behind Strengthen Native American Education; (2) The Johnson O'Malley Program; (3) Legislation to Address…

  12. How Did September 11th Affect Students?

    ERIC Educational Resources Information Center

    Lange, Nancy

    2002-01-01

    There has been much speculation about how terrorist attacks on September 11th affected everyone, including students on college campuses. At Michigan State University, the assistant director of residence life assessment, research and technology decided to investigate. This article presents results of her department's survey. (Author)

  13. 11th International Conference on Atmospheric Electricity

    NASA Technical Reports Server (NTRS)

    Christian, H. J. (Compiler)

    1999-01-01

    This document contains the proceedings from the 11th International Conference on Atmospheric Electricity (ICAE 99), held June 7-11, 1999. This conference was attended by scientists and researchers from around the world. The subjects covered included natural and artificially initiated lightning, lightning in the middle and upper atmosphere (sprites and jets), lightning protection and safety, lightning detection techniques (ground, airborne, and space-based), storm physics, electric fields near and within thunderstorms, storm electrification, atmospheric ions and chemistry, shumann resonances, satellite observations of lightning, global electrical processes, fair weather electricity, and instrumentation.

  14. Accounting Clerk Guide, Learner Packet--Part II. A Spec Unit for the 10th, 11th, or 12th Grade. A Career Education Unit (An Edited Developmental Draft).

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The learner packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing the student for entry into the occupation of accounting clerk. Intended to be used on an individual basis at the student's own speed, the learner packet contains vocabulary, suggested lesson time, self-check keys, and…

  15. Accounting Clerk Guide, Instructor Packet--Part II. A Spec Unit for the 10th, 11th, or 12th Grade. A Career Education Unit (An Edited Developmental Draft).

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The instructor packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing students for entry into the occupation of accounting clerk. The instructor packet lists performance objectives, vocabulary, learning tasks, and supplemental activities for lessons 12 through 21. Pretest and…

  16. Accounting Clerk Guide, Instructor Packet--Part I. A Spec Unit for the 10th, 11th, or 12th Grade. A Career Education Unit (An Edited Developmental Draft).

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The instructor packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing students for entry into the occupation of accounting clerk. The instructor packet lists performance objectives, vocabulary, learning tasks, and supplemental activities for lessons 1 through 11. It also includes…

  17. Accounting Clerk Guide, Learner Packet--Part I. A Spec Unit for the 10th, 11th, or 12th Grade. A Career Education Unit (An Edited Developmental Draft).

    ERIC Educational Resources Information Center

    Foster, Brian; And Others

    The learner packet is part of an eight volume unit for grades 10, 11, and 12, designed for individualized progression in preparing students for entry into the occupation of accounting clerk. Intended to be used on an individual basis at the student's own speed, the learner packet contains vocabulary, suggested lesson time, self-check keys, and…

  18. 11th International Congress of Endocrinology.

    PubMed

    Fuller, P J

    2001-03-01

    The Olympics of endocrinology, the 11th International Congress of Endocrinolgy was held rather appropriately in Sydney, four weeks after the summer games of the XXWIIth Modern Olympiad. Both occasions were a great success and whilst it may be tempting to extend the analogy to the pool or the track or heaven forbid, digress into 'drugs in sport', this review will focus on endocrinology. There were over 3000 participants with ten plenary lectures, 20 meet-the-expert sessions, 41 symposia, 128 oral free communications and 1500 posters. Sydney post-Olympics provided a vibrant, exciting and picturesque setting with outstanding convention facilities. The Congress Party was held at Campbells Cove in the lee of the Harbour Bridge looking toward the Opera House which provided an opportunity for delegates to view the two architectural icons that had become so familiar in the preceding months. Credit must be given both to the Local Organising Committee of Sydney endocrinologists who made it all happen and to the International Program Organising Committee who crafted a pageant of first rate endocrinology. It is self-evident that this report can only hope to give the reader a flavour of a Congress such as this with the choice of topics being largely idiosyncratic. With five concurrent symposia and two concurrent orals each morning and afternoon of the four days, any omissions reflect not on the topic or its importance but on this reviewer's inability to be in more than one place at once! PMID:11424899

  19. NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), SALT LAKE CITY, UT. VIEW LOOKING SOUTH AT CEMETERY'S NORTH GATE (WPA PROJECT, 1938-1941). - Salt Lake City Cemetery, 200 N Street, Salt Lake City, Salt Lake County, UT

  20. High-Grading Lunar Samples

    NASA Technical Reports Server (NTRS)

    Allen, Carlton; Sellar, Glenn; Nunez, Jorge; Mosie, Andrea; Schwarz, Carol; Parker, Terry; Winterhalter, Daniel; Farmer, Jack

    2009-01-01

    Astronauts on long-duration lunar missions will need the capability to high-grade their samples to select the highest value samples for transport to Earth and to leave others on the Moon. We are supporting studies to define the necessary and sufficient measurements and techniques for high-grading samples at a lunar outpost. A glovebox, dedicated to testing instruments and techniques for high-grading samples, is in operation at the JSC Lunar Experiment Laboratory. A reference suite of lunar rocks and soils, spanning the full compositional range found in the Apollo collection, is available for testing in this laboratory. Thin sections of these samples are available for direct comparison. The Lunar Sample Compendium, on-line at http://www-curator.jsc.nasa.gov/lunar/compendium.cfm, summarizes previous analyses of these samples. The laboratory, sample suite, and Compendium are available to the lunar research and exploration community. In the first test of possible instruments for lunar sample high-grading, we imaged 18 lunar rocks and four soils from the reference suite using the Multispectral Microscopic Imager (MMI) developed by Arizona State University and JPL (see Farmer et. al. abstract). The MMI is a fixed-focus digital imaging system with a resolution of 62.5 microns/pixel, a field size of 40 x 32 mm, and a depth-of-field of approximately 5 mm. Samples are illuminated sequentially by 21 light emitting diodes in discrete wavelengths spanning the visible to shortwave infrared. Measurements of reflectance standards and background allow calibration to absolute reflectance. ENVI-based software is used to produce spectra for specific minerals as well as multi-spectral images of rock textures.

  1. The 11th Space Simulation Conference

    NASA Technical Reports Server (NTRS)

    Bond, A. C. (Editor)

    1980-01-01

    Subject areas range from specialized issues dealing with the space and entry environments to the environmental testing of systems and complete spacecraft of present-day vintage. Various papers consider: the test and development of several key systems of the orbiter vehicle; integrated tests of complete satellites; new and unique test facilities developed to meet the demanding requirements of high fidelity simulation of test environments; and contamination species, including the instrumentation for detection and measurement of such. Special topics include improved thermal protection methodologies and approaches, sophisticated sensor developments, and other related testing and development areas.

  2. Impact of the September 11th Terrorist Attacks on Teenagers' Mental Health

    ERIC Educational Resources Information Center

    Gould, Madelyn S.; Munfakh, Jimmie Lou Harris; Kleinman, Marjorie; Lubell, Keri; Provenzano, Danielle

    2004-01-01

    The impact of the September 11th terrorist attacks on adolescents' mental health is reported. Two successive cohorts of students in 6 New York state high schools, identified from health courses, completed an in-school self-report baseline assessment of hopelessness, impairment, and help-seeking behavior. One year later, these students completed a…

  3. Stability and Change in High School Grades

    ERIC Educational Resources Information Center

    Guskey, Thomas R.

    2011-01-01

    This study investigated the stability of students' grades in high school courses during the academic year. Records of over 8,000 high school students from five large southeastern high schools were analyzed to determine the relationship between the first achievement grade students were assigned during an academic term and their final course grades.…

  4. Islamophobia Pre- and Post-September 11th, 2001

    ERIC Educational Resources Information Center

    Sheridan, Lorraine P.

    2006-01-01

    Although much academic research has addressed racism, religious discrimination has been largely ignored. The current study investigates levels of self reported racial and religious discrimination in a sample of 222 British Muslims. Respondents indicate that following September 11th, 2001, levels of implicit or indirect discrimination rose by 82.6%…

  5. High Resolution Telesesimic P-wave Back-Projection Imaging Using Variable Travel Time Corrections: Characterizing Sub-Events of the Great April 11th 2012 Indian Ocean Intraplate Earthquakes

    NASA Astrophysics Data System (ADS)

    Kwong, K. B.; Koper, K. D.; Yue, H.; Lay, T.

    2012-12-01

    Two of the largest strike-slip earthquakes ever recorded occurred off the coast of northern Sumatra on April 11th 2012. The Mw 8.7 mainshock and Mw 8.2 aftershock occurred east of the NinetyEast Ridge in the Wharton Basin, a region of intraplate deformation with prominent fracture zones striking NNE-SSW. The relative lack of geodetic and local seismic data compared to other recent great earthquakes make teleseismic data especially important for understanding the rupture properties of these events. We performed short-period P-wave back-projection imaging using independent networks of stations in Europe and Japan. Preliminary images from the two networks showed similarly complex multi-event sources for the mainshock that indicate rupture occurred along both nodal planes of the gCMT solution, consistent with the locations of early aftershocks. Back-projection images of the Mw 8.2 aftershock showed a single, compact, bilateral rupture corresponding to the NNE-SSW nodal plane of the CMT solution [Yue et al., 2012]. Here we improve upon the resolution and accuracy of our initial back-projection images by estimating station specific travel time corrections that vary across the source region [e.g., Ishii et al., 2007]. These corrections are used to compensate for 3D variations in Earth structure that occur between the source region and the seismometers, and act to focus the array beams. We perform multi-channel cross-correlations of P waves recorded for 7 aftershocks that were (1) distributed broadly around the source region and (2) well-observed at seismometers in Europe. For each seismometer in the array, the 8 measured static corrections are smoothly interpolated over the entire source region with a Kriging method to form a travel time correction surface. These surfaces are then used with an otherwise conventional back-projection approach [Xu et al., 2009] to image the ruptures. Our new images are broadly consistent with our original results, indicating that the

  6. Islamophobia pre- and post-September 11th, 2001.

    PubMed

    Sheridan, Lorraine P

    2006-03-01

    Although much academic research has addressed racism, religious discrimination has been largely ignored. The current study investigates levels of self-reported racial and religious discrimination in a sample of 222 British Muslims. Respondents indicate that following September 11th, 2001, levels of implicit or indirect discrimination rose by 82.6% and experiences of overt discrimination by 76.3%. Thus, the current work demonstrates that major world events may affect not only stereotypes of minority groups but also prejudice toward minorities. Results suggest that religious affiliation may be a more meaningful predictor of prejudice than race or ethnicity. General Health Questionnaire scores indicate that 35.6% of participants likely suffered mental health problems, with significant associations between problem-indicative scores and reports of experiencing a specific abusive incident of September 11th-related abuse by respondents. The dearth of empirical work pertaining to religious discrimination and its effects is a cause for concern. PMID:16443594

  7. Boston Society's 11th Annual Applied Pharmaceutical Analysis conference.

    PubMed

    Lee, Violet; Liu, Ang; Groeber, Elizabeth; Moghaddam, Mehran; Schiller, James; Tweed, Joseph A; Walker, Gregory S

    2016-02-01

    Boston Society's 11th Annual Applied Pharmaceutical Analysis conference, Hyatt Regency Hotel, Cambridge, MA, USA, 14-16 September 2015 The Boston Society's 11th Annual Applied Pharmaceutical Analysis (APA) conference took place at the Hyatt Regency hotel in Cambridge, MA, on 14-16 September 2015. The 3-day conference affords pharmaceutical professionals, academic researchers and industry regulators the opportunity to collectively participate in meaningful and relevant discussions impacting the areas of pharmaceutical drug development. The APA conference was organized in three workshops encompassing the disciplines of regulated bioanalysis, discovery bioanalysis (encompassing new and emerging technologies) and biotransformation. The conference included a short course titled 'Bioanalytical considerations for the clinical development of antibody-drug conjugates (ADCs)', an engaging poster session, several panel and round table discussions and over 50 diverse talks from leading industry and academic scientists. PMID:26853375

  8. PREFACE: The 11th International Superconductive Electronics Conference (ISEC 07)

    NASA Astrophysics Data System (ADS)

    Miller, Donald L.; Wellstood, Fred; Donaldson, Gordon

    2007-11-01

    The 11th International Superconductive Electronics Conference (ISEC 07) was held in June 2007 in Washington, DC, USA. This special issue is a compendium of selected papers based on the technology presented at that meeting. ISEC, held on a biennial basis, traditionally rotates from Japan to Europe to the United States. The single exception to this rotation has been the 2003 conference which was held in Australia. This conference brings together the world's experts in superconductive electronics in a forum which is conducive to interaction among the participants with maximal interchange between the various topics. The conference this year was truly an international event with participation from 13 countries over six continents. The quality of presentations was also high. The conference witnessed the continued maturation of both digital/mixed signal electronics and SQUID-based instrumentation along with a number of novel devices. Of particular note was the transition of superconducting quantum computing research from a novel abstract concept to a broad-based research activity. The organizing committee was able to gather an exemplary group of invited speakers to share their results and visions for future progress. These presentations spanned both the subtopics of superconductor electronics and the history of the field. As I reflect on the efforts which went into making this conference a success, I must express my appreciation to many individuals and organizations, in no particular order. I would like to thank Northrop Grumman for their support for my activities as chair of the conference, both in terms of making my time available and for direct financial considerations. Centennial Conferences, as the conference organizer, provided invaluable guidance and administrative support. I would also like to acknowledge the support of the IEEE Council on Superconductivity, in particular in the persons of Moises Levy and John Spargo. I would be remiss if I did not thank John

  9. Roots of terrorism: a reassessment after September 11th

    SciTech Connect

    Pilat, Joseph F.

    2002-01-01

    The brutal terrorist attacks of September 11th, the anthrax attacks that followed and growing knowledge of al Qaeda's pursuit of nuclear, biological and chemical weapons have not only intensified concerns about terrorism but also created doubts about our understanding of terrorism. These attacks were in many ways unprecedented, and ultimately raise the question of the roots or causes of terrorism. Historically and today, there have been divergent views on this question, which reflect philosophical, religious, political, sociological and other differences. These differences are not merely academic, as they can affect our understanding of both the threat and of responses to terrorism in the aftermath of September 11th, Terrorism is too complex and diverse a phenomenon to speak easily of causes. But we may be able to discern the causes of specific acts. Our response to 9/11 and other acts of terrorism will be affected by our understanding of their causes. If 9/11 was caused by US Middle East policies, the response must involve a review of these policies. If it is a backlash against globalization, the response must address the realities underlying anti-globalization sentiments. Addressing causes will not in any case end terrorism, and addressing the wrong causes will be counterproductive. Actions to reduce those conditions that create support for terrorism and aid its recruitment, which need to be clearly identified, are critical in any counterterrorism strategy. So we must understand the reasons for terrorism and, in particular, for the attacks of September 11th.T his paper will look at the question of the roots of terrorism and then look to the specific case of 911 and its aftermath, with a special view to the impact of globalization.

  10. 11th Annual LVMH Recherche Symposium: skin rejuvenation.

    PubMed

    Bonté, Frédéric

    2012-01-01

    The 11(th) Annual LVMH Recherche Scientific Symposium was held in London on October 27(th), into the warmth of the distinguished British Library, with nearly 150 industry and research attendees. The meeting organized by LVMH Recherche was centered on the theme of skin rejuvenation. The current state of play for rejuvenation research was summarized, and then advances in the science of skin aging and rejuvenation therapies were discussed in detail. Personalized genomics and current and prospective translational therapies were presented, followed by a clever linking of multiple global theories towards a cohesive plan for future goals in rejuvenation research. PMID:22615002

  11. Supracostal Approach for PCNL: Is 10th and 11th Intercostal Space Safe According to Clavien Classification System?

    PubMed

    Kara, Cengiz; Değirmenci, Tansu; Kozacioglu, Zafer; Gunlusoy, Bulent; Koras, Omer; Minareci, Suleyman

    2014-01-01

    The purpose of this study was to evaluate the success and morbidity of percutaneous nephrolithotomy (PCNL) performed through the 11th and 10th intercostal space. Between March 2005 and February 2012, 612 patients underwent PCNL, 243 of whom had a supracostal access. The interspace between the 11th and 12th rib was used in 204 cases (group 1) and between the 10th and 11th interspaces in 39 cases (group 2). PCNL was performed using standard supracostal technique in all patients. The operative time, success rate, hospital stay, and complications according to the modified Clavien classification were compared between group 1 and group 2. The stone-free rate was 86.8% in group 1 and 84.6% in group 2 after one session of PCNL. Auxiliary procedures consisting of ureterorenoscopy (URS) and shock wave lithotripsy (SWL) were required in 5 and 7 patients, respectively, in group 1; and in 1 patient each in group 2 . After the auxiliary procedures, stone-free rates increased to 92.6% in group 1 and 89.7% in group 2. A total of 74 (30.4%) complications were documented in the 2 groups according to modified Clavien classification. Grade-I complications were recorded in 20 (8.2%), grade-II in 38 (15.6%), grade-IIIa in 13 (5.3%), and grade-IIIb in 2 (0.8%) patients; grade-IVa was recorded in 1 (0.4%) patient. There were no grade-IVb or grade-V complications. Overall complication rate was 30.9% in group 1 and 28.2% in group 2. Supracostal PCNL in selected cases is effective and safe with acceptable complications. The modified Clavien system provides a standardized grading system for complications of PCNL. PMID:25437600

  12. 77 FR 21107 - Agency Information Collection Activities: Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... Information Collection Activities: Proposed Collection; Comments Requested: September 11th Victim Compensation... Review. The Department of Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be... required to respond, as well as a brief abstract: Primary: The September 11th Victim Compensation Fund...

  13. 77 FR 5056 - Agency Information Collection Activities: Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Information Collection Activities: Proposed Collection; Comments Requested: September 11th Victim Compensation... review. The Department of Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be... required to respond, as well as a brief abstract: Primary: The September 11th Victim Compensation Fund...

  14. PREFACE: 11th European Conference on Applied Superconductivity (EUCAS2013)

    NASA Astrophysics Data System (ADS)

    Farinon, Stefania; Pallecchi, Ilaria; Malagoli, Andrea; Lamura, Gianrico

    2014-05-01

    During the 11th edition of the European Conference on Applied Superconductivity, successfully held in Genoa from 15-19 September 2013, more than one thousand participants from over 40 countries were registered and contributions of 7 plenary lectures, 23 invited talks, 203 oral talks and 550 posters were presented. The present issue of Journal of Physics: Conference Series (JPCS) collects the 218 submitted papers that were peer reviewed and accepted in the Conference Proceedings. Similarly to the Superconductor Science and Technology Special issue: ''EUCAS 11th European Conference on Applied Superconductivity'' which contains some plenary and invited contributions, as well as some selected contributions, in this issue the papers are sorted according to the four traditional topics of interest of EUCAS, namely Materials (56 papers), Wires and Tapes (47 papers), Large Scale Applications (64 papers) and Electronics (51 papers). While the it Superconductors Science and Technology special issue focuses on the scientific and technological highlights of the conference, this collection provides an overall view of the worldwide research activity on applied superconductivity, mirroring the main guidelines and the hottest issues, which range from basic studies on newly discovered superconducting compounds to the state-of-the-art advances in large scale applications, wires and tapes fabrication and electronics. We would like to point out that, among the JPCS contributions, six papers present works financed by ongoing EU-Japan projects, three papers belong to the session on junctions and SQUIDs dedicated to the memory of Antonio Barone and one paper belongs to the session on pinning and flux dynamics dedicated to the memory of John Clem. Finally, we would like to thank all the people whose careful work contributed to the preparation of this JPCS issue, in particular the session chairs as well as the peer reviewers. The Editors Stefania Farinon (Editor in Chief, Large Scale

  15. Evolutionary etiology of high-grade astrocytomas

    PubMed Central

    Song, Yurong; Zhang, Qian; Kutlu, Burak; Difilippantonio, Simone; Bash, Ryan; Gilbert, Debra; Yin, Chaoying; O’Sullivan, T. Norene; Yang, Chunyu; Kozlov, Serguei; Bullitt, Elizabeth; McCarthy, Ken D.; Kafri, Tal; Louis, David N.; Miller, C. Ryan; Hood, Leroy; Van Dyke, Terry

    2013-01-01

    Glioblastoma (GBM), the most common brain malignancy, remains fatal with no effective treatment. Analyses of common aberrations in GBM suggest major regulatory pathways associated with disease etiology. However, 90% of GBMs are diagnosed at an advanced stage (primary GBMs), providing no access to early disease stages for assessing disease progression events. As such, both understanding of disease mechanisms and the development of biomarkers and therapeutics for effective disease management are limited. Here, we describe an adult-inducible astrocyte-specific system in genetically engineered mice that queries causation in disease evolution of regulatory networks perturbed in human GBM. Events yielding disease, both engineered and spontaneous, indicate ordered grade-specific perturbations that yield high-grade astrocytomas (anaplastic astrocytomas and GBMs). Impaired retinoblastoma protein RB tumor suppression yields grade II histopathology. Additional activation of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) network drives progression to grade III disease, and further inactivation of phosphatase and tensin homolog (PTEN) yields GBM. Spontaneous missense mutation of tumor suppressor Trp53 arises subsequent to KRAS activation, but before grade III progression. The stochastic appearance of mutations identical to those observed in humans, particularly the same spectrum of p53 amino acid changes, supports the validity of engineered lesions and the ensuing interpretations of etiology. Absence of isocitrate dehydrogenase 1 (IDH1) mutation, asymptomatic low grade disease, and rapid emergence of GBM combined with a mesenchymal transcriptome signature reflect characteristics of primary GBM and provide insight into causal relationships. PMID:24114272

  16. Correlations among Five Demographic Variables and the Performance of Selected Jamaican 11th-Graders on Some Numerical Problems on Energy

    ERIC Educational Resources Information Center

    Emepue, Nicholas; Soyibo, Kola

    2009-01-01

    This study was designed to assess whether the level of performance of selected Jamaican 11th-grade physics students on some numerical problems on the energy concept was satisfactory and if there were significant differences in their performance linked to their gender, socioeconomic background (SEB), school location, English language and…

  17. 11th European VLBI Network Symposium & Users Meeting

    NASA Astrophysics Data System (ADS)

    The Laboratoire d'Astrophysique de Bordeaux (LAB) at the University of Bordeaux (France), on behalf of the European VLBI Consortium, hosted the 11th European VLBI Network (EVN) Symposium and EVN Users Meeting on October 9-12, 2012. The Symposium was held at the "Chambre de Commerce et d'Industrie de Bordeaux", located in the "Palais de la Bourse", in the center of Bordeaux. The conference highlighted the latest scientific results and technical developments from VLBI, space VLBI and e-VLBI. All fields of astrophysics were concerned - stellar, galactic and extragalactic - as well as astrometry and planetary science. Presentations addressing synergy between (e-)VLBI and other new or planned radio facilities (ALMA, LOFAR, e-MERLIN,...) or instruments at other wavelengths (Fermi, CTA, Gaia,...) were also an integral part of the program. The scientific program was organized in 11 sessions including 71 oral presentations, with an additional 43 posters available for viewing during the entire length of the conference. An EVN Users Meeting was also held during one of the evening to foster interaction between the EVN users and the EVN organization. The symposium was attended by a total of 122 delegates originating from 47 institutes world-wide, sharing new VLBI science and innovations while also building links with other communities. The research leading to these results has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 283393 (RadioNet3).

  18. Studies on high grade cerebral gliomas

    SciTech Connect

    Bleehen, N.M. )

    1990-04-01

    A brief review of attempts in the United Kingdom to improve the results of treatment of high grade (grade 3, 4) supra-tentorial astrocytomas is presented. The radiosensitizer misonidazole failed to improve the results of post-surgical radiotherapy, however, multivariate analysis of data from these patients has provided a prognostic index of use in defining good and poor prognosis patients. An overview study of adjuvant nitrosourea therapy trials has shown a small significant advantage for the chemotherapy. A study of chemosensitization by benznidazole of CCNU treatment of patients in relapse failed to demonstrate any effect. 13 references.

  19. High School Grading Policies. Research Notes. RN-04

    ERIC Educational Resources Information Center

    Camara, Wayne J.

    1998-01-01

    To obtain information on current high school grading policies, additional questions were included on the College Board's High School Profile in 1997. Results of the survey provide insight into the following grading policies across high schools: a large majority of schools (91 percent) use the traditional grading system A-F, or numeric grades; 92.2…

  20. The roots of terrorism: A reassessment after September 11th

    SciTech Connect

    Pilat, Joseph F.

    2002-01-01

    The brutal terrorist attacks of September 11th, the anthrax attacks that followed and growing knowledge of al Qaeda's pursuit of nuclear, biological and chemical weapons have not only intensified concerns about terrorism but also created doubts about our understanding of terrorism. These attacks were in many ways unprecedented, and ultimately raise the question of the roots or causes of terrorism. Historically and today, there have been divergent views on this question, which reflect philosophical, religious, political and other differences. These differences are not merely academic, as they can affect our understanding of both the threat and of responses to terrorism in the aftermath of September 1 1 th. Terrorism is too complex and diverse a phenomenon to speak easily of causes. But we may be able to discern the causes of specific acts. Our response to 9/11 and other acts of terrorism will be affected by our understanding of their causes, as well as by possible political requirements to address widespread perceptions of causes. If 9/11 was caused by Islamic radicalism, the near-term response must be to ensure the terrorists are defeated and pose no fiuther danger. In the longer term, education is critical. If the attacks were caused by US Middle East policies, the response should involve a review of those policies. This may or may not result in changes to policy, public diplomacy, etc. If the attacks were a backlash against globalization, the response must address the realities underlying anti-globalization sentiments. Addressing causes (real and perceived) will not in any case end terrorism, and addressing the wrong causes can be counterproductive. Actions to reduce those conditions that create support for terrorism and aid its recruitment effort are critical to any counterterrorism strategy. For this reason alone, we must do everything possible to understand the reasons terrorism may be undertaken, including the attacks of September 1 1 th. This paper will look

  1. Improvement in High-Grade Osteosarcoma Survival

    PubMed Central

    Hung, Giun-Yi; Yen, Hsiu-Ju; Yen, Chueh-Chuan; Wu, Po-Kuei; Chen, Cheng-Fong; Chen, Paul C-H; Wu, Hung-Ta H.; Chiou, Hong-Jen; Chen, Wei-Ming

    2016-01-01

    Abstract The aim of this study was to compare survival before and after 2004 and define the prognostic factors for high-grade osteosarcomas beyond those of typical young patients with localized extremity disease. Few studies have reported the long-term treatment outcomes of high-grade osteosarcoma in Taiwan. A total of 202 patients with primary high-grade osteosarcoma who received primary chemotherapy at Taipei Veterans General Hospital between January 1995 and December 2011 were retrospectively evaluated and compared by period (1995–2003 vs 2004–2011). Patients of all ages and tumor sites and those following or not following controlled protocols were included in analysis of demographic, tumor-related, and treatment-related variables and survival. Overall survival and progression-free survival at 5 years were, respectively, 67.7% and 48% for all patients (n = 202), 77.3% and 57.1% for patients without metastasis (n = 157), and 33.9% and 14.8% for patients with metastasis (n = 45). The survival rates of patients treated after 2004 were significantly higher (by 13%–16%) compared with those of patients treated before 2004, with an accompanying 30% increase in histological good response rate (P = .002). Factors significantly contributing to inferior survival in univariate and multivariate analyses were diagnosis before 2004, metastasis at diagnosis, and being a noncandidate for a controlled treatment protocol. By comparison with the regimens used at our institution before 2004, the current results support the effectiveness of the post-2004 regimens, which consisted of substantially reduced cycles of high-dose methotrexate and a higher dosage of ifosfamide per cycle, cisplatin, and doxorubicin, for treating high-grade osteosarcoma in Asian patients. PMID:27082623

  2. 77 FR 4827 - Agency Information Collection Activities; Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Information Collection Activities; Proposed Collection; Comments Requested: September 11th Victim Compensation... Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be submitting the following... the Form/Collection: Victim Compensation Objection Form. (3) Agency form number, if any, and...

  3. 77 FR 21107 - Agency Information Collection Activities: Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... Information Collection Activities: Proposed Collection; Comments Requested: September 11th Victim Compensation... Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be submitting the following.../Collection: Victim Compensation Objection Form. (3) Agency form number, if any, and the applicable...

  4. 77 FR 26043 - Agency Information Collection Activities; Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... Information Collection Activities; Proposed Collection; Comments Requested: September 11th Victim Compensation... Department of Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be submitting the...) Type of Information Collection: New collection. (2) Title of the Form/Collection: Victim...

  5. 77 FR 21997 - Agency Information Collection Activities: Proposed Collection; Comments Requested: September 11th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... Information Collection Activities: Proposed Collection; Comments Requested: September 11th Victim Compensation... Justice (DOJ), Civil Division, September 11th Victim Compensation Fund, will be submitting the following.../Collection: Victim Compensation Objection Form. (3) Agency form number, if any, and the applicable...

  6. Gene therapy for high-grade glioma

    PubMed Central

    Natsume, Atsushi

    2008-01-01

    The treatment of high-grade gliomas remains difficult despite recent advances in surgery, radiotherapy and chemotherapy. True advances may emerge from the increasing understanding in molecular biology and discovery of novel mechanisms for the delivery of tumoricidal agents. In an attempt to overcome this formidable neoplasm, molecular approaches using gene therapy have been investigated clinically since 1992. The clinical trials have mainly been classified into three approaches: suicide gene therapy, immune gene therapy and oncolytic viral therapy. In this article, we review these approaches, which have been studied in previous and ongoing clinical trials. PMID:19262115

  7. Are High School Grades Inflated? Issues in College Readiness

    ERIC Educational Resources Information Center

    ACT, Inc., 2005

    2005-01-01

    To find out whether high school grade inflation exists, data drawn from students who took the ACT in the eleventh or twelfth grades and graduated from public high schools were examined. Because grade inflation is by definition a factor that develops over time, data from a relatively long period, 1991 to 2003, or 13 years were used. The number of…

  8. E SERIES MAGAZINES, OVERVIEW OF REAR OF MAGAZINES FROM 11TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    E SERIES MAGAZINES, OVERVIEW OF REAR OF MAGAZINES FROM 11TH ST. E 106 IN THE FOREGROUND. - Naval Magazine Lualualei, Headquarters Branch, Magazine Type, Eleventh, Thirteenth, Fifteenth, Sixteenth, & Seventeenth Streets, Pearl City, Honolulu County, HI

  9. 16. NORTHEAST CORNER VIEW OF 10TH AND 11TH FLOOR WINDOWS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. NORTHEAST CORNER VIEW OF 10TH AND 11TH FLOOR WINDOWS. CORNER SHOWS THE DIAGONALLY FLUTED SPIRAL DESIGN OF THE RELIEF COLUMN. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

  10. The Effects of 11th Graders' Opinions on Their Interpretation of Conflicting Arguments.

    ERIC Educational Resources Information Center

    Slater, Wayne H.

    1998-01-01

    Examines how individual differences in epistemological beliefs, strength of beliefs, and need for cognition affected the written conclusions that 11th graders constructed after reading a passage presenting arguments opposing and supporting gun control. (SR)

  11. VIEW OF COMPANY HOUSES ON 11TH STREET AT THE RAILROAD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF COMPANY HOUSES ON 11TH STREET AT THE RAILROAD TRACKS. No. 401 to right (asbestos siding). House on left has retained the original clapboard siding. - Town of Windber, Windber, Somerset County, PA

  12. 14. CLOSEUP VIEW OF THE 10TH AND 11TH FLOOR WINDOWS. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. CLOSE-UP VIEW OF THE 10TH AND 11TH FLOOR WINDOWS. WINDOWS HAVE WHITE TERRA COTTA SILLS, HEADS AND MULLIONS. ARCHES ARE OF TERRA COTTA INCLUDING ORNAMENTATION ABOVE THE 11TH FLOOR WINDOWS. CIRCULAR ORNAMENTATIONS BETWEEN ARCHES ARE TERRA COTTA PAINTED IN BRONZE COLOR. LOUVERS ON THE WINDOWS ARE NOT PART OF THE ORIGINAL DESIGN. THIS IS THE FRONT ELEVATION. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

  13. Emotional Intelligence and Academic Achievement in 11th Grade At-Risk Students

    ERIC Educational Resources Information Center

    Nelson, Patricia Diane

    2009-01-01

    As the emphasis on measures of student academic achievement increases, educational researchers and practitioners are interested in identifying factors that demonstrate effectiveness in supporting student achievement. This quantitative, correlational study explored the influence of emotional intelligence on closing the achievement gap. A study of…

  14. Project Probase: Engaging Technology for 11th and 12th Grade Students

    ERIC Educational Resources Information Center

    Wyse-Fisher, Dustin J.; Daugherty, Michael K.; Satchwell, Richard E.; Custer, Rodney L.

    2005-01-01

    Journal manuscripts and national reports published during the last 20 years (Bensen, 1993; DeVries, 1996; AAAS, 1989; National Academy of Engineering, 2002; ITEA, 1996; Zuga, 1989) presented a defensible rationale for the technology education profession and focused on the delivery of technological literacy for the nation's youth. This call for…

  15. Modeling the Relationship between High School Students' Chemistry Self-Efficacy and Metacognitive Awareness

    ERIC Educational Resources Information Center

    Kirbulut, Zubeyde Demet

    2014-01-01

    In this study, the relationship between students' chemistry self-efficacy beliefs and metacognitive awareness was investigated utilizing a path model. There were 268 chemistry high school students (59% 10th grade and 41% 11th grade) participated in the study. The students took two-hour chemistry course in the 9th and 10th grade and three-hour…

  16. Shortcut: High School Grades as a Signal of Human Capital.

    ERIC Educational Resources Information Center

    Miller, Shazia Rafiullah

    1998-01-01

    Explores whether employers could benefit from using high school grades to identify valuable workers. Data from the High School and Beyond study show that high school grades do have a strong and significant effect on earnings nine years after high school for men and women even after controlling for race/ethnicity. (SLD)

  17. Grades, Coursework, and Student Characteristics in High School Economics

    ERIC Educational Resources Information Center

    Rebeck, Ken; Walstad, William B.

    2015-01-01

    The authors use U.S. public and private high school transcripts to analyze grade distribution patterns in economics courses across student and school characteristics, and compare these grades to those earned in other selected high school courses. Results are reported for the 53 percent of 2009 high school graduates who took a basic economics…

  18. PREFACE: 11th Anglo-French Physical Acoustics Conference (AFPAC 2012)

    NASA Astrophysics Data System (ADS)

    Saffari, Nader; Lhémery, Alain; Lowe, Mike

    2013-08-01

    The 11th Anglo-French Physical Acoustics Conference (AFPAC) was held in Brighton, UK on 18-20 January 2012. This event, which is an annual collaboration between the Physical Acoustics Group (PAG) of the Institute of Physics and the Groupe d'Acoustique Physique, Sous-marine et UltraSonore (GAPSUS) of the Société Française d'Acoustique, successfully achieved its main aim of being a small, friendly meeting of high scientific quality, welcoming younger researchers and PhD students and covering a broad range of subjects in Acoustics. The participants heard 44 excellent presentations covering an exciting and diverse range of subjects, from audio acoustics to guided waves in composites and from phononic crystals to ultrasound surgery. As is the custom at these meetings, four prominent invited speakers set the pace for the event; these were Keith Attenborough (The Open University, UK), Claire Prada (Institut Langevin, France), David Moore (University of Nottingham, UK) and Philippe Roux (IS Terre, France). The submission of manuscripts for publication in the proceedings was, as in previous years, on a voluntary basis and in these proceedings we present 11 peer reviewed papers. Due to some unforeseen problems there has been a longer than planned delay in preparing these proceedings, for which the Editors sincerely apologise to the authors and the community. Nader Saffari, Mike Lowe and Alain Lhémery

  19. Gut Microbiome of an 11th Century A.D. Pre-Columbian Andean Mummy.

    PubMed

    Santiago-Rodriguez, Tasha M; Fornaciari, Gino; Luciani, Stefania; Dowd, Scot E; Toranzos, Gary A; Marota, Isolina; Cano, Raul J

    2015-01-01

    The process of natural mummification is a rare and unique process from which little is known about the resulting microbial community structure. In the present study, we characterized the microbiome of paleofeces, and ascending, transverse and descending colon of an 11th century A.D. pre-Columbian Andean mummy by 16S rRNA gene high-throughput sequencing and metagenomics. Firmicutes were the most abundant bacterial group, with Clostridium spp. comprising up to 96.2% of the mummified gut, while Turicibacter spp. represented 89.2% of the bacteria identified in the paleofeces. Microbiome profile of the paleofeces was unique when compared to previously characterized coprolites that did not undergo natural mummification. We identified DNA sequences homologous to Clostridium botulinum, Trypanosoma cruzi and human papillomaviruses (HPVs). Unexpectedly, putative antibiotic-resistance genes including beta-lactamases, penicillin-binding proteins, resistance to fosfomycin, chloramphenicol, aminoglycosides, macrolides, sulfa, quinolones, tetracycline and vancomycin, and multi-drug transporters, were also identified. The presence of putative antibiotic-resistance genes suggests that resistance may not necessarily be associated with a selective pressure of antibiotics or contact with European cultures. Identification of pathogens and antibiotic-resistance genes in ancient human specimens will aid in the understanding of the evolution of pathogens as a way to treat and prevent diseases caused by bacteria, microbial eukaryotes and viruses. PMID:26422376

  20. Gut Microbiome of an 11th Century A.D. Pre-Columbian Andean Mummy

    PubMed Central

    Santiago-Rodriguez, Tasha M.; Fornaciari, Gino; Luciani, Stefania; Dowd, Scot E.; Toranzos, Gary A.; Marota, Isolina; Cano, Raul J.

    2015-01-01

    The process of natural mummification is a rare and unique process from which little is known about the resulting microbial community structure. In the present study, we characterized the microbiome of paleofeces, and ascending, transverse and descending colon of an 11th century A.D. pre-Columbian Andean mummy by 16S rRNA gene high-throughput sequencing and metagenomics. Firmicutes were the most abundant bacterial group, with Clostridium spp. comprising up to 96.2% of the mummified gut, while Turicibacter spp. represented 89.2% of the bacteria identified in the paleofeces. Microbiome profile of the paleofeces was unique when compared to previously characterized coprolites that did not undergo natural mummification. We identified DNA sequences homologous to Clostridium botulinum, Trypanosoma cruzi and human papillomaviruses (HPVs). Unexpectedly, putative antibiotic-resistance genes including beta-lactamases, penicillin-binding proteins, resistance to fosfomycin, chloramphenicol, aminoglycosides, macrolides, sulfa, quinolones, tetracycline and vancomycin, and multi-drug transporters, were also identified. The presence of putative antibiotic-resistance genes suggests that resistance may not necessarily be associated with a selective pressure of antibiotics or contact with European cultures. Identification of pathogens and antibiotic-resistance genes in ancient human specimens will aid in the understanding of the evolution of pathogens as a way to treat and prevent diseases caused by bacteria, microbial eukaryotes and viruses. PMID:26422376

  1. 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research | Division of Cancer Prevention

    Cancer.gov

    The NIH Pain Consortium will convene the 11th Annual NIH Pain Consortium Symposium on Advances in Pain Research, featuring keynote speakers and expert panel sessions on Innovative Models and Methods. The first keynote address will be delivered by David J. Clark, MD, PhD, Stanford University entitled “Challenges of Translational Pain Research: What Makes a Good Model?” |

  2. 11th International congress on catalysis - 40th anniversary. Part A and B

    SciTech Connect

    Hightower, J.W.; Delgass, W.N.; Iglesia, E.; Bell, A.T.

    1996-12-31

    Reports are presented from the 11th International Congress On Catalysis. Topics are concerned with surface properties, processing and conversion of hydrocarbons, photocatalytic activity, pollution control, oxidation, environmental catalysis, characterization methods, and deactivation. Individual papers have processed separately for the United states Department of Energy databases.

  3. The Federal Forecasters Conference--2000. Papers and Proceedings (11th, Washington, DC, September 14, 2000).

    ERIC Educational Resources Information Center

    Gerald, Debra, E., Ed.

    The 11th Federal Forecasters Conference provided a forum where 180 forecasters from different federal agencies and other organizations could meet and discuss forecasting in the United States. The theme for this conference was "Forecasting, Policy, and the Internet." In the morning session, a panel presentation featured three speakers. Neilson C.…

  4. 77 FR 43823 - Filing Dates for the Michigan Special Election in the 11th Congressional District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Filing Dates for the Michigan Special Election in the 11th Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Michigan has...

  5. Education Scholars' Reflections on the Implications of September 11th for Curriculum.

    ERIC Educational Resources Information Center

    Pace, Judith L.

    2002-01-01

    Presents the reflections of five educational scholars on the potential impact of the events of September 11th on curriculum and how to address it. Edited excerpts are featured from Maxine Greene, Nel Noddings, Jesse Goodman, Michael Apple, and Gloria Ladson-Billings. Respondents address such issues as cultural awareness, moral education, and…

  6. Coping with Terrorism: Age and Gender Differences in Effortful and Involuntary Responses to September 11th

    ERIC Educational Resources Information Center

    Wadsworth, Martha E.; Gudmundsen, Gretchen R.; Raviv, Tali; Ahlkvist, Jarl A.; McIntosh, Daniel N.; Kline, Galena H.; Rea, Jacqueline; Burwell, Rebecca A.

    2004-01-01

    This study examined age and gender differences and similarities in stress responses to September 11th. Adolescents, young adults, and adults reported using a variety of strategies to cope with the terrorist attacks including acceptance, positive thinking, and emotional expression. In addition, involuntary stress responses such as physiological…

  7. Review of "The September 11th Education Program: A National Interdisciplinary Curriculum"

    ERIC Educational Resources Information Center

    Waterson, Robert A.; Jenne, Katherine

    2011-01-01

    A review of "The September 11th Education Program: A National Interdisciplinary Curriculum" reveals a sensitive and well-created program for the 5-12 social studies teacher to use in teaching about the challenging subject of 9/11. This program provides an opportunity for teachers to find a balance among understanding, critical analysis,…

  8. September 11th, the Internet, and the Affects on Information Provision in Libraries.

    ERIC Educational Resources Information Center

    Hamilton, Stuart

    The September 11th terrorist attacks on the United States have contributed greatly to a change in the information environment around the world. The weeks following the attacks saw governments around the world rush to pass legislation designed to prevent future acts of terrorism. Much of this legislation targeted information flow, especially on the…

  9. Labor Market Effects of September 11th on Arab and Muslim Residents of the United States

    ERIC Educational Resources Information Center

    Kaushal, Neeraj; Kaestner, Robert; Reimers, Cordelia

    2007-01-01

    We investigated whether the September 11, 2001 terrorists' attacks had any effect on employment, earnings, and residential mobility of first- and second-generation Arab and Muslim men in the United States. We find that September 11th did not significantly affect employment and hours of work of Arab and Muslim men, but was associated with a 9-11…

  10. Asian Studies: Experimental Course of Study, 11th or 12th Year Elective.

    ERIC Educational Resources Information Center

    Fryberg, Carl

    This experimental course of study has a twofold purpose. Primarily, it is intended to serve as basis for an elective for the 11th or 12th year student. Openended in organization, it encourages teachers and students to add new dimensions. It provides a comprehensive bibliography and detailed information with which to develop an elective in the area…

  11. Relationship between High School Leadership Team Practices and Student Achievement

    ERIC Educational Resources Information Center

    McInnis, Timothy M.

    2009-01-01

    This study investigated if a relationship existed between student achievement in 10th grade Missouri Assessment Program mathematics and 11th grade communication arts scores in 2007 and high school leadership team perceptions of the extent to which they demonstrated leadership practices. The secondary purpose was to compare perceptional…

  12. Photodynamic therapy of Cervical Intraepithelial Neoplasia (CIN) high grade

    NASA Astrophysics Data System (ADS)

    Carbinatto, Fernanda M.; Inada, Natalia M.; Lombardi, Welington; da Silva, Eduardo V.; Belotto, Renata; Kurachi, Cristina; Bagnato, Vanderlei S.

    2016-02-01

    Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer and associated with human papillomavirus (HPV) infection. Photodynamic therapy (PDT) is a technique that has been used for the treatment of tumors. PDT is based on the accumulation of a photosensitizer in target cells that will generate cytotoxic reactive oxygen species upon illumination, inducing the death of abnormal tissue and PDT with less damaging to normal tissues than surgery, radiation, or chemotherapy and seems to be a promising alternative procedure for CIN treatment. The CIN high grades (II and III) presents potential indications for PDT due the success of PDT for CIN low grade treatment. The patients with CIN high grade that were treated with new clinic protocol shows lesion regression to CIN low grade 60 days after the treatment. The new clinical protocol using for treatment of CIN high grade shows great potential to become a public health technique.

  13. High School Mathematics Teachers: Grading Practice and Pupil Control Ideology.

    ERIC Educational Resources Information Center

    Cicmanec, Karen Mauck; Johanson, George; Howley, Aimee

    Survey data gathered from 230 respondents from a random sample of 500 Ohio public school teachers explores the association between teachers' practice of assigning grades based on nonachievement grading factors and teachers' pupil control orientation (PCI). Responding high school mathematics teachers provided information that relates to the use of…

  14. Reliability of Grading High School Work in English

    ERIC Educational Resources Information Center

    Brimi, Hunter M.

    2011-01-01

    This research replicates the work of Starch and Elliot (1912) by examining the reliability of the grading by English teachers in a single school district. Ninety high school teachers graded the same student paper following professional development sessions in which they were trained to use NWREL's "6+1 Traits of Writing." These participants had…

  15. Follow-up of a cross-national comparison on flashbulb and event memory for the September 11th attacks.

    PubMed

    Curci, Antonietta; Luminet, Olivier

    2006-04-01

    Flashbulb memories are defined as vivid and long-lasting memories for the reception context of an important public event (Brown & Kulik, 1977). They are supposed to be triggered by both emotional reactions to the original event and rehearsal processes (Brown & Kulik, 1977; Finkenauer, Luminet, Gisle, El-Ahmadi, van der Linden, & Philippot, 1998; Neisser & Harsch, 1992). A test-retest design (21 vs 524 days after the event on average) was employed to assess flashbulb memory and event memory for the September 11th attacks and the impact of their emotional and rehearsal predictors in a sample of 985 respondents coming from six countries (i.e., Belgium, Italy, the Netherlands, Romania, Japan, and the USA). Results showed that national membership had a significant impact on event memory, and the emotional and rehearsal variables, but flashbulb memories for the September 11th attacks were found to be high and consistent across different countries. The implications of these findings for the debate about the nature and maintenance of flashbulb memories are discussed. PMID:16574589

  16. A rational characterization of proprietary High Collapse casing grades

    SciTech Connect

    Klementich, E.F.

    1995-12-31

    An increasing number of users are finding it necessary to utilize {open_quotes}High Collapse{close_quotes} casing grades for deep set and intermediate size drilling and production casing strings. Unfortunately, the great variety of proprietary (non-API) high collapse casing grades has made it extremely difficult for drilling and completion engineers to logically select the optimum size, weight, and grade of pipe meeting the design objective, due to the wide variation in collapse resistance claims and the guaranteed pipe dimensional and mechanical properties supporting that claim. This paper provides a technically sound method for selecting and safely using high collapse pipe.

  17. Identifying combinations of risk and protective factors predicting physical activity change in high school students.

    PubMed

    Dunton, Genevieve Fridlund; Atienza, Audie A; Tscherne, James; Rodriguez, Daniel

    2011-02-01

    Research sought to identify combinations of risk and protective factors predicting change in physical activity (PA) over one year in high school students. Adolescents (N = 344; M = 15.7 years) participated in a longitudinal study with assessment of demographics, substance use/smoking exposure, height and weight, psychological factors, and PA in 10th and 11th grade. PA participation in 11th grade was greatest for adolescents who engaged in PA and had high sports competence (78%), and least for adolescents who did not engage in or enjoy PA (13%) in 10th grade. Identifying adolescent subgroups at risk for decreasing PA can inform the development of tailored interventions. PMID:21467595

  18. Distinction of brain tissue, low grade and high grade glioma with time-resolved fluorescence spectroscopy.

    PubMed

    Yong, William H; Butte, Pramod V; Pikul, Brian K; Jo, Javier A; Fang, Qiyin; Papaioannou, Thanassis; Black, Keith; Marcu, Laura

    2006-01-01

    Neuropathology frozen section diagnoses are difficult in part because of the small tissue samples and the paucity of adjunctive rapid intraoperative stains. This study aims to explore the use of time-resolved laser-induced fluorescence spectroscopy as a rapid adjunctive tool for the diagnosis of glioma specimens and for distinction of glioma from normal tissues intraoperatively. Ten low grade gliomas, 15 high grade gliomas without necrosis, 6 high grade gliomas with necrosis and/or radiation effect, and 14 histologically uninvolved "normal" brain specimens are spectroscopicaly analyzed and contrasted. Tissue autofluorescence was induced with a pulsed Nitrogen laser (337 nm, 1.2 ns) and the transient intensity decay profiles were recorded in the 370-500 nm spectral range with a fast digitized (0.2 ns time resolution). Spectral intensities and time-dependent parameters derived from the time-resolved spectra of each site were used for tissue characterization. A linear discriminant analysis diagnostic algorithm was used for tissue classification. Both low and high grade gliomas can be distinguished from histologically uninvolved cerebral cortex and white matter with high accuracy (above 90%). In addition, the presence or absence of treatment effect and/or necrosis can be identified in high grade gliomas. Taking advantage of tissue autofluorescence, this technique facilitates a direct and rapid investigation of surgically obtained tissue. PMID:16368511

  19. 1. Mill exterior, high grade chute partially restored on the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Mill exterior, high grade chute partially restored on the outside of mill building center of picture. Looking northeast from below bridge. - Kennecott Copper Corporation, Concentration Mill, On Copper River & Northwestern Railroad, Kennicott, Valdez-Cordova Census Area, AK

  20. 40 CFR 246.200 - High-grade paper recovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  1. 40 CFR 246.200 - High-grade paper recovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  2. 40 CFR 246.200 - High-grade paper recovery.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  3. 40 CFR 246.200 - High-grade paper recovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  4. 40 CFR 246.200 - High-grade paper recovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  5. High-Grading Lunar Samples for Return to Earth

    NASA Technical Reports Server (NTRS)

    Allen, Carlton; Sellar, Glenn; Nunez, Jorge; Winterhalter, Daniel; Farmer, Jack

    2009-01-01

    Astronauts on long-duration lunar missions will need the capability to "high-grade" their samples to select the highest value samples for transport to Earth and to leave others on the Moon. We are supporting studies to defile the "necessary and sufficient" measurements and techniques for highgrading samples at a lunar outpost. A glovebox, dedicated to testing instruments and techniques for high-grading samples, is in operation at the JSC Lunar Experiment Laboratory.

  6. Overexpression of Eg5 correlates with high grade astrocytic neoplasm.

    PubMed

    Liu, Liqiong; Liu, Xichun; Mare, Marcus; Dumont, Aaron S; Zhang, Haitao; Yan, Dong; Xiong, Zhenggang

    2016-01-01

    To investigate the relationship between Eg5 and histopathological grade of astrocytoma, Eg5 expression was evaluated by immunohistochemical examination on 88 specimens including 25 cases of glioblastoma (WHO grade IV), 22 cases of anaplastic astrocytoma (WHO grade III), 20 cases of diffuse astrocytoma (WHO grade II), and 21 cases of pilocytic astrocytoma (WHO grade I). The histopathological characteristics and Eg5 expression level of each tumor were assessed and statistically analyzed. Astrocytic tumors exhibited significant correlation of expression of Eg5 with higher WHO histopathological grades (p < 0.001). Eg5 is expressed in 51-98% (mean 76.88%) of neoplastic cells in glioblastoma, 34-57% (mean 43.59%) of neoplastic cells in anaplastic astrocytoma, 6-36% (mean 18.60%) of neoplastic cells in diffuse astrocytoma, and 2-28% (mean 13.48%) of neoplastic cells in pilocytic astrocytoma. In conclusion, overexpression of Eg5 associates with high-grade astrocytic neoplasm, and it may represent an independent diagnostic and prognostic factor in grading astrocytic tumors and predicting prognosis of astrocytic tumor patients. PMID:26456023

  7. Surgical Outcomes of High-Grade Spinal Cord Gliomas

    PubMed Central

    Hida, Kazutoshi; Yano, Syunsuke; Aoyama, Takeshi; Koyanagi, Izumi; Houkin, Kiyohiro

    2015-01-01

    Study Design A retrospective study. Purpose The purpose of this study was to obtain useful information for establishing the guidelines for treating high-grade spinal cord gliomas. Overview of Literature The optimal management of high-grade spinal cord gliomas remains controversial. We report the outcomes of the surgical management of 14 high-grade spinal glioma. Methods We analyzed the outcomes of 14 patients with high-grade spinal cord gliomas who were surgically treated between 1989 and 2012. Survival was charted with the Kaplan-Meier plots and comparisons were made with the log-rank test. Results None of the patients with high-grade spinal cord gliomas underwent total resection. Subtotal resection was performed in two patients, partial resection was performed in nine patients, and open biopsy was performed in three patients. All patients underwent postoperative radiotherapy and six patients further underwent radiation cordotomy. The median survival time for patients with high-grade spinal cord gliomas was 15 months, with a 5-year survival rate of 22.2%. The median survival time for patients with World Health Organization grade III tumors was 25.5 months, whereas the median survival time for patients with glioblastoma multiforme was 12.5 months. Both univariate and multivariate Cox proportional hazards models demonstrated a significant effect only in the group that did not include cervical cord lesion as a factor associated with survival (p=0.04 and 0.03). Conclusions The surgical outcome of patients diagnosed with high-grade spinal cord gliomas remains poor. Notably, only the model which excluded cervical cord lesions as a factor significantly predicted survival. PMID:26713128

  8. The Reporting of the September 11th Terrorist Attacks in American Social Studies Textbooks: A Muslim Perspective

    ERIC Educational Resources Information Center

    Saleem, Mohammed M.; Thomas, Michael K.

    2011-01-01

    This study analyzes the reporting of the September 11th terrorist attacks in social studies textbooks from a Muslim perspective and reports on findings from a study of the responses of American Muslim children to the treatment of the events of September 11th in social studies textbooks. Constructivist grounded theory was used to centralize the…

  9. Mutations in chromatin machinery and pediatric high-grade glioma

    PubMed Central

    Lulla, Rishi R.; Saratsis, Amanda Muhs; Hashizume, Rintaro

    2016-01-01

    Pediatric central nervous system tumors are the most common solid tumor of childhood. Of these, approximately one-third are gliomas that exhibit diverse biological behaviors in the unique context of the developing nervous system. Although low-grade gliomas predominate and have favorable outcomes, up to 20% of pediatric gliomas are high-grade. These tumors are a major contributor to cancer-related morbidity and mortality in infants, children, and adolescents, with long-term survival rates of only 10 to 15%. The recent discovery of somatic oncogenic mutations affecting chromatin regulation in pediatric high-grade glioma has markedly improved our understanding of disease pathogenesis, and these findings have stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. We review the current perspective on pediatric high-grade glioma genetics and epigenetics, and discuss the emerging and experimental therapeutics targeting the unique molecular abnormalities present in these deadly childhood brain tumors. PMID:27034984

  10. Mutations in chromatin machinery and pediatric high-grade glioma.

    PubMed

    Lulla, Rishi R; Saratsis, Amanda Muhs; Hashizume, Rintaro

    2016-03-01

    Pediatric central nervous system tumors are the most common solid tumor of childhood. Of these, approximately one-third are gliomas that exhibit diverse biological behaviors in the unique context of the developing nervous system. Although low-grade gliomas predominate and have favorable outcomes, up to 20% of pediatric gliomas are high-grade. These tumors are a major contributor to cancer-related morbidity and mortality in infants, children, and adolescents, with long-term survival rates of only 10 to 15%. The recent discovery of somatic oncogenic mutations affecting chromatin regulation in pediatric high-grade glioma has markedly improved our understanding of disease pathogenesis, and these findings have stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. We review the current perspective on pediatric high-grade glioma genetics and epigenetics, and discuss the emerging and experimental therapeutics targeting the unique molecular abnormalities present in these deadly childhood brain tumors. PMID:27034984

  11. Medical interventions for high grade vulval intraepithelial neoplasia

    PubMed Central

    Pepas, Litha; Kaushik, Sonali; Bryant, Andrew; Nordin, Andy; Dickinson, Heather O

    2014-01-01

    Background Vulval intraepithelial neoplasia (VIN) is a pre-malignant condition of the vulval skin; its incidence is increasing in women under 50 years. VIN is graded histologically as low grade or high grade. High grade VIN is associated with infection with human papilloma virus (HPV) infection and may progress to invasive disease. There is no consensus on the optimal management of high grade VIN. The high morbidity and high relapse rate associated with surgical interventions call for a formal appraisal of the evidence available for less invasive but effective interventions for high grade VIN. Objectives To evaluate the effectiveness and safety of medical interventions for high grade VIN. Search methods We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 3), MEDLINE and EMBASE (up to September 2010). We also searched registers of clinical trials, abstracts of scientific meetings, reference lists of included studies and contacted experts in the field. Selection criteria Randomised controlled trials (RCTs) that assessed medical interventions, in adult women diagnosed with high grade VIN. Data collection and analysis Two review authors independently abstracted data and assessed risk of bias. Where possible the data were synthesised in a meta-analysis. Main results Four trials met our inclusion criteria: three assessed the effectiveness of topical imiquimod versus placebo in women with high grade VIN; one examined low versus high dose indole-3-carbinol in similar women. Meta-analysis of three trials found that the proportion of women who responded to treatment at 5 to 6 months was much higher in the group who received topical imiquimod than in the group who received placebo (relative risk (RR) = 11.95, 95% confidence interval (CI) 3.21 to 44.51). A single trial showed similar results at 12 months in (RR = 9.10, 95% CI 2.38 to 34.77). Only one trial reported

  12. The Effect of a Zoo-Based Experiential Academic Science Program on High School Students' Math and Science Achievement and Perceptions of School Climate

    ERIC Educational Resources Information Center

    Mulkerrin, Elizabeth A.

    2012-01-01

    The purpose of this study was to determine the effect of an 11th-grade and 12th-grade zoo-based academic high school experiential science program compared to a same school-district school-based academic high school experiential science program on students' pretest and posttest science, math, and reading achievement, and student perceptions of…

  13. Selective nonoperative management of high grade splenic trauma.

    PubMed

    Branco, Bernardino C; Tang, Andrew L; Rhee, Peter; Fraga, Gustavo Pereira; Nascimento, Bartolomeu; Rizoli, Sandro; O'Keeffe, Terence

    2013-01-01

    The "Evidence-based Telemedicine - Trauma & Acute Care Surgery" (EBT-TACS) Journal Club performed a critical review of the literature and selected three up-to-date articles on the management of splenic trauma. Our focus was on high-grade splenic injuries, defined as AAST injury grade III-V. The first paper was an update of the 2003 Eastern Association for the Surgery of Trauma (EAST) practice management guidelines for nonoperative management of injury to the spleen. The second paper was an American Association for the Surgery of Trauma (AAST) 2012 plenary paper evaluating the predictive role of contrast blush on CT scan in AAST grade IV and V splenic injuries. Our last article was from Europe and investigates the effects of angioembolization of splenic artery on splenic function after high-grade splenic trauma (AAST grade III-V). The EBT-TACS Journal Club elaborated conclusions and recommendations for the management of high-grade splenic trauma. PMID:23912375

  14. Middle Grades and High Schools Use Effective Strategies to Prepare Students for Challenging High School Studies. High Schools That Work

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2011

    2011-01-01

    Middle grades schools have their hands full in working with elementary schools and high schools to improve the likelihood of success for middle grades students--accelerating learning, helping elementary students move seamlessly into the middle grades, preparing middle grades students for rigorous high school courses, changing organization and…

  15. Geodetically derived fault slip distribution model for the May, 11th 2011 Lorca earthquake (SE, Spain)

    NASA Astrophysics Data System (ADS)

    Gonzalez, P. J.; Tiampo, K. F.; Palano, M.; Cannavò, F.; Fernandez, J.

    2011-12-01

    The Alhama de Murcia Fault (AMF) is a compound multisegmented right-lateral to reverse fault system. The AMF is one the longest faults in the Eastern Betics Shear zone (Southeastern Spain). In the last decades its seismogenic potential has been evaluated and earthquake maximum magnitudes were forecast based on paleoseismic and dating data. On May 11th, 2011 a moderate (Mw 5.1) earthquake shook the region, causing 9 casualties and severe damages in Lorca city (Murcia region). The reported location of the aftershocks sequence did not follow any particular trend; furthermore in-situ geology surveys did not identify any fault slip related ground deformation. To contribute to a better seismic hazard assessment, we need to locate and, if possible, characterize the fault-slip distribution that generated the earthquake. In this work, we detected small but significant ground deformation in the epicentral area by using geodetic (GPS and satellite radar interferometry) data. Geodetic data was processed by using a stack of differential radar interferometry (corrected for a known subsidence contribution and estimating their error budget), daily GPS estimated coordinates and high-rate 1-Hz GPS data. We jointly inverted the detected static coseismic displacements (a GPS station and two ENVISAT interferograms from different tracks) for the fault plane geometry parameters by using a rectangular dislocation model embedded in a homogeneous elastic half-space. The best-fitting fault plane follows closely the geologically derived AMF geometry (NE-SW strike trend and dipping ~60-70o to NW). Later, the obtained model geometry was extended and divided into patches to allow for a detailed analysis of the fault slip distribution pattern. Slip distribution indicates that slip occurred in a single patch with reverse and right-lateral motion (with peak fault slip magnitude of ~9 cm). However, the modelling results also indicate that the fault slip was shallower along the centre and southwest

  16. Predicting Grades in Specific College Freshman Courses from ACT Test Scores and Self-Reported High School Grades. November 1987.

    ERIC Educational Resources Information Center

    Noble, Julie P.; Sawyer, Richard

    The validity of American College Testing Program (ACT) test scores and self-reported high school grades for predicting grades in specific college freshman courses was studied. Specific course grades are typically used to place students in remedial, standard, or advanced classes. These placement decisions, in turn, have immediate implications for…

  17. High School Extracurricular Activities & College Grades.

    ERIC Educational Resources Information Center

    Rombokas, Mary; And Others

    Many factors influence the development and socialization of American adolescents including peers, schools, family, and the community. This paper examines how the relationship of extracurricular participation influences academic growth. To determine if selected personal and academic variables during high school currently affect college academic…

  18. Process Makes High-Grade Silicon

    NASA Technical Reports Server (NTRS)

    Keller, Rudolf

    1988-01-01

    Reactants and electrolyte recycled to yield relatively pure product. Process based on reaction of silicon dioxide with aluminum. Aluminum for process taken from operating aluminum-electrolysis cell, and Al2O3 product returned to same cell. Aluminum continually recycled and purified, and purity of silicon high as well.

  19. The Effects of Block Scheduling on High School Academic Achievement

    ERIC Educational Resources Information Center

    Lewis, Chance W.; Dugan, James J.; Winokur, Marc A.; Cobb, Brian R.

    2005-01-01

    The effect of block scheduling on high school student achievement in mathematics and reading was investigated in this study through the use of an ex post-facto, longitudinal research design. Specifically, student scores from 9th and 11th-grade standardized tests were matched and sorted by junior high and high school attended. Outcome measures…

  20. The "What Is a System" Reflection Interview as a Knowledge Integration Activity for High School Students' Understanding of Complex Systems in Human Biology

    ERIC Educational Resources Information Center

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-01-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of "systems language" amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade--one at the beginning of the school year and one at its end.…

  1. PREFACE: 11th International Conference on Electrorheological Fluids and Magnetorheological Suspensions

    NASA Astrophysics Data System (ADS)

    Odenbach, Stefan; Borin, Dmitry

    2009-07-01

    Materials with properties controllable by external fields become more and more important for modern product design. Magnetorheological suspensions, electrorheological fluids and ferrofluids are classical examples for such smart materials exhibiting magnetic or electric field dependent properties. Their development over the past 60 years has shown how complex research and development of fluids with tailored properties can be. The demands of potential applications are the driving force for the synthesis of new fluids. The changes in the synthetic process and the composition of the fluids based on an increasing understanding of the relevant microscopic processes leads to certain macroscopic properties of the material. Only intense cooperation between basic and application oriented research, synthesis, characterisation, theory and application design can finally lead to fluids suitable for the envisaged use. The International Conferences on Electrorheological Fluids and Magnetorheological Suspensions have provided over more than 20 years a platform for interdisciplinary discussions strengthening the scientific progress in the field. Besides being a forum for scientific exchange about recent developments in electro- and magnetorheological fluids. The 11th International Conference on Electrorheological Fluids and Magnetorheological Suspensions (ERMR08) which has been organized by the chair of Magnetofluiddynamics at the Technische Universität Dresden in August 2008 in Dresden has continued this fruitful tradition. With more than 180 participants from 24 different countries it has been the largest ERMR meeting during the last decade - a tendency showing the high potential and promising development of the field of electrically and magnetically controllable fluids. A significant proportion of the participants were PhD students, a fact that also highlights the sustainability of the field. In total 85 oral presentations - including 8 plenary talks - and 81 posters were

  2. The Influence of Principal Transformational Leadership Style on High School Proficiency Test Results in New Jersey Comprehensive and Vocational-Technical High Schools.

    ERIC Educational Resources Information Center

    Verona, Gail S.; Young, John W.

    The New Jersey High School Proficiency Test (HSPT) is a "high stakes" test administered as a graduation requirement to all 11th grade students in New Jersey high schools. High school principals have been held increasingly accountable for successful HSPT scores. This study used Leithwood's model of transformational leadership (K. Leithwood, 1994),…

  3. High School Grades and University Performance: A Case Study

    ERIC Educational Resources Information Center

    Cyrenne, Philippe; Chan, Alan

    2012-01-01

    A critical issue facing a number of colleges and universities is how to allocate first year places to incoming students. The decision to admit students is often based on a number of factors, but a key statistic is a student's high school grades. This paper reports on a case study of the subsequent performance at the University of Winnipeg of high…

  4. Environmental Education for Junior High Grades: A Teacher's Manual.

    ERIC Educational Resources Information Center

    Michigan State Dept. of Natural Resources, Lansing.

    Teaching suggestions for environmental education in junior high school grades are grouped under five general headings: "Geology,""Water Resources,""Soil and Land Use,""Trees, Woodlots, and Forests," and "Wild-life and Fishes." Listed under each heading are attitudes and understandings to develop, topics for discussion, and many suggested…

  5. BUENA VISTA HIGH SCHOOL--DESCRIPTIVE ANALYSIS.

    ERIC Educational Resources Information Center

    EGBERT, ROBERT L.

    A DETAILED SYSTEM DESCRIPTION OF THE 11TH-GRADE ENGLISH COURSE WHICH COMBINES TEAM TEACHING WITH CLOSED-CIRCUIT TELEVISION AT THE BUENA VISTA HIGH SCHOOL IN SAGINAW, MICHIGAN, WAS PRESENTED. THE SECOND IN A SERIES OF THREE REPORTS, THIS REPORT PRESENTED AN ANALYSIS OF (1) COURSE OPERATING PROCEDURES, (2) TIME SPENT IN VARIOUS GROUPINGS AND…

  6. PREFACE: 11th International Conference on Damage Assessment of Structures (DAMAS 2015)

    NASA Astrophysics Data System (ADS)

    Wahab, M. A.

    2015-07-01

    This volume contains the proceedings of the 11th International Conference on Damage Assessment of Structures (DAMAS) 2015. DAMAS has a long history of almost 20 years. The first DAMAS conference took place in 1995 (Pescara, Italy), followed by a biannual meeting in 1997 (Sheffield, UK), 1999 (Dublin, Ireland), 2001 (Cardiff, UK), 2003 (Southampton, UK), 2005 (Gdansk, Poland), 2007 (Torino, Italy), 2009 (Beijing, China), 2011 (Oxford, UK) and 2013 (Dublin, Ireland). The eleventh edition of DAMAS conference series, DAMAS 2015, is hosted by Ghent University, Belgium, and is held at the congress center Het Pand in Ghent city. Ghent is the capital and the largest city of the East Flanders province of the Flemish region of Belgium. Het Pand is the culture and congress center of Ghent University and is a historical monument. The conference is established as a major international forum for research topics relevant to damage assessment of engineering structures and systems including numerical simulations, signal processing of sensor measurements and theoretical techniques as well as experimental case studies. The presentations of DAMAS 2015 are divided into 6 main sessions, namely 1) Structural Health and Condition Monitoring, 2) Damage in Civil Engineering, 3) Damage in Machineries, 4) Damage in Composite Materials, 5) Sensing and Sensors and 6) Signal Processing. The organising committee is grateful to keynote speakers; Professor Guido De Roeck, Head of Structural Mechanics Division, KULeuven, Belgium, for his keynote lecture entitled 'Structural Health Monitoring: highlights and challenges', Professor Weidong Zhu, Department of Mechanical Engineering, University of Maryland, USA, for his keynote lecture entitled 'Vibration-based Structural Damage Detection: Theory and Applications' and Professor Wieslaw Ostachowicz, Head of the Laboratory of Active Materials and Smart Structures, Polish Academy of Sciences, Poland, for his keynote lecture entitled 'Damage Assessment and

  7. PREFACE: 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers

    NASA Astrophysics Data System (ADS)

    Takizuka, Tomonori

    2008-07-01

    This volume of Journal of Physics: Conference Series contains papers based on invited talks and contributed posters presented at the 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers. This meeting was held at the Tsukuba International Congress Center in Tsukuba, Japan, on 26-28 September 2007, and was organized jointly by the Japan Atomic Energy Agency and the University of Tsukuba. The previous ten meetings in this series were held in San Diego (USA) 1987, Gut Ising (Germany) 1989, Abingdon (UK) 1991, Naka (Japan) 1993, Princeton (USA) 1995, Kloster Seeon (Germany) 1997, Oxford (UK) 1999, Toki (Japan) 2001, San Diego (USA) 2003, and St Petersburg (Russia) 2005. The purpose of the eleventh meeting was to present and discuss new results on H-mode (edge transport barrier, ETB) and internal transport barrier, ITB, experiments, theory and modeling in magnetic fusion research. It was expected that contributions give new and improved insights into the physics mechanisms behind high confinement modes of H-mode and ITBs. Ultimately, this research should lead to improved projections for ITER. As has been the tradition at the recent meetings of this series, the program was subdivided into six topics. The topics selected for the eleventh meeting were: H-mode transition and the pedestal-width Dynamics in ETB: ELM threshold, non-linear evolution and suppression, etc Transport relations of various quantities including turbulence in plasmas with ITB: rotation physics is especially highlighted Transport barriers in non-axisymmetric magnetic fields Theory and simulation on transport barriers Projections of transport barrier physics to ITER For each topic there was an invited talk presenting an overview of the topic, based on contributions to the meeting and on recently published external results. The six invited talks were: A Leonard (GA, USA): Progress in characterization of the H-mode pedestal and L-H transition N Oyama (JAEA, Japan): Progress and issues in

  8. The Relationship of Grade Span in 9th Grade to Math Achievement in High School

    ERIC Educational Resources Information Center

    West, John; Miller, Mary Lou; Myers, Jim; Norton, Timothy

    2015-01-01

    Purpose, Scope, and Method of Study: The purpose of this study was to determine if a correlation exists between grade span for ninth grade and gains in math achievement test scores in 10th grade and 12th grade. A quantitative, longitudinal, correlational research design was employed to investigate the research questions. The population was high…

  9. Would Einstein be proficient? A study of high school science course sequencing and proficiency on FCAT science

    NASA Astrophysics Data System (ADS)

    Nearor, Nicole D.

    The main focus of this study was to investigate if, or to what extent, there is a significant relationship between high school science course sequencing and proficiency on 11th grade Florida Comprehensive Assessment Test (FCAT) Science. The Florida Legislature mandated a specific number of sciences as a requirement for graduation. High schools students must have "three credits in science, two of which must have a laboratory component" (Florida Legislature, 2010). There is no recommendation from the Florida Department of Education on which high school science courses will most likely prepare students to be proficient on 11th grade FCAT Science. This study provides data for local school districts to determine which high school science courses can lead to proficiency on standardized science assessments. Further, this research can be used to help Florida school districts meet the Race To The Top mandates for Science, Technology, Engineering, and Mathematics. Local school districts can analyze current science sequences are not meeting the goals of increasing student performance in STEM-related courses, then "reorder the curriculum to support better aligned learning experiences for students" (FCR-STEM, 2011, p. 15). The recommendations from this research can help state education departments to conduct annual science assessments to examine science progress that will help lead students towards the most appropriate high school STEM-related career academy. Archived, quantitative data was used to conduct bivariate, correlational tests to investigate if a statistically significant relationship existed between high school science course sequencing and 11th grade FCAT Science proficiency. Moreover, both the 10th grade FCAT Reading scores and 10 th grade FCAT Mathematics scores were analyzed to see if either 10 th grade standardized test had a greater association to proficiency on the 11th grade FCAT Science. All of the null hypotheses were rejected. Based upon the findings of

  10. High Frequency Ultrasound of Armor-Grade Alumina Ceramics

    NASA Astrophysics Data System (ADS)

    Bottiglieri, S.; Haber, R. A.

    2009-03-01

    Different lots of high density, commercial, armor-grade alumina (Al2O3) were tested using high frequency ultrasound in order to determine any correlation between measured properties and ballistic performance. C-scan images were taken using a 15 MHz ultrasonic transducer in order to form attenuation coefficient and elastic property maps. These samples were further characterized by using quantitative analysis. The results indicate that attenuation coefficient values appear to have the strongest correlation, of every property measured, to ballistic classifications.

  11. Graded High Field Nb3Sn Dipole Magnets

    SciTech Connect

    Caspi, S.; Ferracin, P.; Gourlay, S.

    2007-06-01

    Dipole magnets with fields beyond 16T will require superconducting coils that are at least 40 mm thick, an applied pres-stress around 150 MPa and a protection scheme for stored energy in the range of 1-2 MJ/m. The coil size will have a direct impact on the overall magnet cost and the stored energy will raise new questions on protection. To reduce coil size and minimize risk, the coil may have to be graded. Grading is achieved by splitting the coil into several layers with current densities that match the short sample field in each layer. Grading, especially at high fields, can be effective; however it will also significantly raise the stress. In this paper we report on the results of a study on the coil size and field relation to that of the stress and stored energy. We then extend the results to graded coils and attempt to address high stress issues and ways to reduce it.

  12. Perceptions of Teen Pregnancy among High School Students in Sweet Home, Oregon

    ERIC Educational Resources Information Center

    Little, Tim; Henderson, Jessica; Pedersen, Peggy; Stonecipher, Linda

    2010-01-01

    Background: The purpose of this study was to gain insights into the perceptions and attitudes about teen pregnancy among high school students in a rural area with high teen pregnancy rates. Methods: Five focus groups were conducted with: (1) females in 9th-10th grades; (2) females in 11th-12th grades; (3) males in 9th-10th grades; (4) males in…

  13. High-Grade Sarcomas Mimicking Traumatic Intramuscular Hematomas

    PubMed Central

    Gomez, Pablo; Morcuende, Jose

    2004-01-01

    We reported on three patients with high-grade soft-tissue sarcomas mimicking traumatic intramuscular hematomas. Patients had an episode of trauma to the extremity, and after initial clinical and imaging evaluations they were considered to have muscular hematomas. The lesions increased in size over time, leading to further evaluations that demonstrated the actual diagnosis. We conducted a retrospective review of the clinical findings, magnetic resonance images, and computed tomography scans to assess characteristics that will help in the differential diagnosis. We conclude that intramuscular hematomas following trauma should be approached with a high degree of clinical suspicion. MRI analysis can be used as an important diagnostic tool, but the results must be seen in the context of the clinical history. MRI is not sensitive or specific enough to rule out malignancy. The diagnosis of a high-grade sarcoma must be considered in these patients and any doubt should be resolved with a biopsy. PMID:15296215

  14. 11th National Conference on Science, Policy, and the Environment: Our Changing Oceans

    SciTech Connect

    Peter Saundry

    2012-04-17

    On January 19-21, 2011, The National Council for Science and the Environment (NCSE) successfully convened its 11th National Conference on Science, Policy and the Environment: Our Changing Oceans in Washington, DC at the Ronald Reagan Building and International Trade Center. Over 1,247 participants attended the conference, representing federal, state and local governments, university and colleges across the US, civil society organizations, the business community, and international entities. In addition, the conference was webcast to an audience across several states. The conference provided a forum to examine the profound changes our ocean will undergo over the next 25-50 years and share various perspectives on the new research, tools, and policy initiatives to protect and sustain our ocean. Conference highlights and recommendations are available to the public on NCSE's conference website, www.OurChangingOceans.org.

  15. A Study Comparing the Academic Achievement of African American Male Students Enrolled in Two Types of Nontraditional High Schools

    ERIC Educational Resources Information Center

    Rutledge, Anthony B.

    2010-01-01

    This study examined the relationship of the achievement of African American male students enrolled in an early college high school to those enrolled in a performing arts high school. The Georgia High School Graduation Test (GHSGT) scores of the 11th-grade African American male students from an early college high school were compared to the GHSGT…

  16. Wake of September 11th attacks: implications for research, policy and practice.

    PubMed

    Darden, Madeline Lyles

    2002-02-01

    The National Consortium for African American Children (NCAAC) held a National Forum on Bioterrorism and Children on November 6, 2001 in Washington, DC. Convened in the wake of the September 11th attacks on New York City and the Pentagon, this unprecedented conference assembled a cross-section of professionals in child advocacy, health, mental health, insurance, economics, law enforcement, and media technology. The ensuing discussion focused on issues surrounding biological agents, their impact on children and youth, and the strategies needed to protect the health and mental health of children and families in the event of a large-scale bioterrorist crisis. Lessons learned as well as the implications of the terrorist acts from the tragic events of September 11th formed the backdrop for engaging dialogue among various industry executives and professionals. Accounts of personal experiences during the unprecedented tragedy of 9-11 were shared and provided a context for heightened preparedness planning for children and adults. A collaborative statement was also presented by NCAAC, the National Medical Association, the Association of Black Psychologists, and the National Black Media Coalition. This forum was hailed as a model for communities of color to join and help bolster broad-based coalition building to ensure the availability of culturally and linguistically appropriate messages, services, and support. As intended, the forum devoted significant attention to the special needs of children, their caregivers and families and provided for an invaluable interchange which is slated to evolve into a national action plan to address the imminent dangers facing our nation's children. PMID:11853055

  17. Mixed low grade and high grade endometrial stromal sarcoma of uterus: differences on immunohistochemistry and chromosome in situ hybridisation.

    PubMed Central

    Cheung, A N; Ng, W F; Chung, L P; Khoo, U S

    1996-01-01

    A case of a 64 year old woman with a tumour of the uterus is reported. The patient presented with postmenopausal bleeding and subsequently underwent total hysterectomy and bilateral salpingo-oophorectomy. Sections of the tumour showed a low grade endometrial stromal sarcoma coexisting with areas consistent with high grade sarcoma. The sarcoma cells, in both the low and high grade areas, were positive for vimentin and negative for desmin and cytokeratin on immunohistochemistry. While the sarcoma cells in the low grade region showed immunoreactivity for oestrogen and progestogen receptors, those in the high grade region did not. Using chromosome in situ hybridisation, the low grade portion of the sarcoma was diploid for chromosomes X, 11, 12, and 17, whereas the more anaplastic areas were aneuploid for these chromosomes. This case may represent an example of high grade endometrial stromal sarcoma arising by dedifferentiation from a low grade stromal sarcoma. Adequate sampling is important in identifying such anaplastic changes as the origin of the tumour will affect patient management. Images PMID:8813967

  18. Irradiation of Pediatric High-Grade Spinal Cord Tumors

    SciTech Connect

    Tendulkar, Rahul D.; Pai Panandiker, Atmaram S.; Wu Shengjie; Kun, Larry E.; Broniscer, Alberto; Sanford, Robert A.; Merchant, Thomas E.

    2010-12-01

    Purpose: To report the outcome using radiation therapy (RT) for pediatric patients with high-grade spinal cord tumors. Methods and Materials: A retrospective chart review was conducted that included 17 children with high-grade spinal cord tumors treated with RT at St. Jude Children's Research Hospital between 1981 and 2007. Three patients had gross total resection, 11 had subtotal resection, and 3 underwent biopsy. The tumor diagnosis was glioblastoma multiforme (n = 7), anaplastic astrocytoma (n = 8), or anaplastic oligodendroglioma (n = 2). Seven patients received craniospinal irradiation (34.2-48.6 Gy). The median dose to the primary site was 52.2 Gy (range, 38-66 Gy). Results: The median progression-free and overall survivals were 10.8 and 13.8 months, respectively. Local tumor progression at 12 months (79% vs. 30%, p = 0.02) and median survival (13.1 vs. 27.2 months, p = 0.09) were worse for patients with glioblastoma multiforme compared with anaplastic astrocytoma or oligodendroglioma. The median overall survival was shorter for patients when failure included neuraxis dissemination (n = 8) compared with local failure alone (n = 5), 9.6 vs. 13.8 months, p = 0.08. Three long-term survivors with World Health Organization Grade III tumors were alive with follow-up, ranging from 88-239 months. Conclusions: High-grade spinal cord primary tumors in children have a poor prognosis. The propensity for neuraxis metastases as a component of progression after RT suggests the need for more aggressive therapy.

  19. High School FCS Program Reaches Out to Senior Citizens

    ERIC Educational Resources Information Center

    Sowers, Margaret A.

    2007-01-01

    "Bridging the Gap: Intergenerational Appreciation" is an educational partnership between community residents and high school family and consumer sciences (FCS) students in the Cornwall-Lebanon School District in Lebanon, Pennsylvania. The program provides 10th, 11th, and 12th grade students opportunities to be actively involved with the older…

  20. Biomechanics of high-grade spondylolisthesis with and without reduction.

    PubMed

    Wang, Wenhai; Aubin, Carl-Eric; Cahill, Patrick; Baran, George; Arnoux, Pierre-Jean; Parent, Stefan; Labelle, Hubert

    2016-04-01

    The clinical advantages of reducing spondylolisthesis over fusion in situ have several intuitive reasons such as restore the spinal column into a more anatomic relationship and alignment. However, there is only little evidence in the literature supporting the theoretical advantages of reduction, and its effect on spinopelvic alignment remains poorly defined. In this study, a comprehensive finite element model was developed to analyze the biomechanics of the spine after spinal fusion at L5-S1 in both types of high-grade spondylolisthesis (balanced and unbalanced pelvis). The relevant clinical indices (i.e. spondylolisthesis grade and Dubousset lumbosacral angle), the displacement of L4-L5, pressure within the annulus and nucleus, and stress at L4-L5 were evaluated and compared. The model can well predict the changes of the important clinical indices during the surgery. For a balanced pelvis, the reduction has a minimal effect on the biomechanical conditions at the adjacent level during postsurgical activities. In the unbalanced case, reduction induced larger deformation in the lumbosacral region and a higher stress concentration at adjacent level. Whether such a stress concentration can lead to long-term disc degeneration is not known. The results provide additional information for the clinician considering reduction of high-grade spondylolisthesis. PMID:26233229

  1. Team-Based Learning for Students with High-Incidence Disabilities in High School Social Studies Classrooms

    ERIC Educational Resources Information Center

    Kent, Shawn; Wanzek, Jeanne; Swanson, Elizabeth A.; Vaughn, Sharon

    2015-01-01

    We examined the effectiveness of implementing team-based learning (TBL) practices on content acquisition for 11th grade students with high-incidence disabilities enrolled in general education social studies courses. TBL components focus on collaborative discourse within heterogeneous teams. TBL, which requires critical thinking and the application…

  2. Treatment of children with high grade glioma with nimotuzumab

    PubMed Central

    Cabanas, Ricardo; Saurez, Giselle; Rios, Martha; Alert, Jose; Reyes, Adnolys; Valdes, Jose; Gonzalez, Maria C.; Pedrayes, Jorge L.; Avila, Melba; Herrera, Raiza; Infante, Mariela; Echevarria, Ernesto; Moreno, Myrna; Luaces, Patricia Lorenzo; Ramos, Tania Crombet

    2013-01-01

    Brain tumors are a major cause of cancer-related mortality in children. Overexpression of epidermal growth factor receptor (EGFR) is detected in pediatric brain tumors and receptor density appears to increase with tumor grading. Nimotuzumab is an IgG1 antibody that targets EGFR. Twenty-three children with high-grade glioma (HGG) were enrolled in an expanded access program in which nimotuzumab was administered alone or with radio-chemotherapy. The mean number of doses was 39. Nimotuzumab was well-tolerated and treatment with the antibody yielded a survival benefit: median survival time was 32.66 mo and the 2-y survival rate was 54.2%. This study demonstrated the feasibility of prolonged administration of nimotuzumab and showed preliminary evidence of clinical benefit in HGG patients with poor prognosis. PMID:23575267

  3. Molecular characteristics of pediatric high-grade gliomas

    PubMed Central

    Chamdine, Omar; Gajjar, Amar

    2014-01-01

    SUMMARY High-grade gliomas (HGGs) are extremely lethal tumors. Survival has not changed significantly in the past decades. The only known prognostic factors in pediatric HGGs (pHGGs) are extent of resection and histologic grade. Treatment has historically been based on adult trials because of the rarity of pHGGs and the lack of genomic tools to explore their unique molecular characteristics. The recent advances in molecular biological data helped divide these tumors into distinct subgroups. In this review, the authors focus on major molecular targets of alterations in pHGGs: histone H3.3, telomeres, PDGFRA, IDH, BRAFV600E, ACVR1 and NTRK and briefly highlight the difference with the adult counterpart. PMID:25438814

  4. Has the Mediterranean Sea Felt the March 11th, 2011, M 9.0 Tohoku-Oki Earthquake (japan) ?

    NASA Astrophysics Data System (ADS)

    Anzidei, M.; Vecchio, A.; Carbone, V.; Arena, G.

    2011-12-01

    Sea level recordings from about 200 available tide gauge stations located along the coast of Japan and elsewhere in the world, including the Mediterranean basin, were analysed to investigate the far field effects of the giant tsunami caused by the March 11th, 2011, M 9.0 Tohoku-Oki earthquake. The tsunami was generated offshore the Honshu island (Japan) and propagated in the Oceans. While the near field tide gauge stations show a saturated signal due to the very high tsunami waves, the Mediterranean tide gauge stations have likely recorded a weak signal that disturbed the daily tidal trends. In this report we briefly show and discuss the analysis of tidal data from some selected tide gauge stations located in the Mediterranean sea, including the Italian tide gauge network consisting in 30 stations. Global sea level data were retrieved by internet from IOC (http://www.ioc-sealevelmonitoring.org/) and ISPRA for the Italian region(http://www.mareografico.it/). Tidal data were reduced for inverse barometric correction and analyzed by an advanced filtering technique that decomposes a non-stationary time series X(t) through oscillating modes, identifying the contributions at different timescales of the tidal variations. Finally, we focused on the dynamical behavior of low-frequency processes and trends.

  5. PREFACE: 11th International Conference on Nucleus-Nucleus Collisions (NN2012)

    NASA Astrophysics Data System (ADS)

    Li, Bao-An; Natowitz, Joseph B.

    2013-03-01

    The 11th International Conference on Nucleus-Nucleus Collisions (NN2012) was held from 27 May to 1 June 2012, in San Antonio, Texas, USA. It was jointly organized and hosted by The Cyclotron Institute at Texas A&M University, College Station and The Department of Physics and Astronomy at Texas A&M University-Commerce. Among the approximately 300 participants were a large number of graduate students and post-doctoral fellows. The Keynote Talk of the conference, 'The State of Affairs of Present and Future Nucleus-Nucleus Collision Science', was given by Dr Robert Tribble, University Distinguished Professor and Director of the TAMU Cyclotron Institute. During the conference a very well-received public lecture on neutrino astronomy, 'The ICEcube project', was given by Dr Francis Halzen, Hilldale and Gregory Breit Distinguished Professor at the University of Wisconsin, Madison. The Scientific program continued in the general spirit and intention of this conference series. As is typical of this conference a broad range of topics including fundamental areas of nuclear dynamics, structure, and applications were addressed in 42 plenary session talks, 150 parallel session talks, and 21 posters. The high quality of the work presented emphasized the vitality and relevance of the subject matter of this conference. Following the tradition, the NN2012 International Advisory Committee selected the host and site of the next conference in this series. The 12th International Conference on Nucleus-Nucleus Collisions (NN2015) will be held 21-26 June 2015 in Catania, Italy. It will be hosted by The INFN, Laboratori Nazionali del Sud, INFN, Catania and the Dipartimento di Fisica e Astronomia of the University of Catania. The NN2012 Proceedings contains the conference program and 165 articles organized into the following 10 sections 1. Heavy and Superheavy Elements 2. QCD and Hadron Physics 3. Relativistic Heavy-Ion Collisions 4. Nuclear Structure 5. Nuclear Energy and Applications of

  6. Exploring the Impact of Career Mentoring on High School Dropout: A Qualitative Phenomenological Investigation

    ERIC Educational Resources Information Center

    Raffington Ameir, Caroline

    2012-01-01

    According to Department of Education reports on public high school dropout rates for 2009, a national average of 44.3% of dropouts left their secondary school education in the 11th and 12th grades. The majority of school dropouts attributed the reason for dropping out of school to boredom. High social and economic costs associated with dropping…

  7. Metaphors Developed by High-School Students towards the Concept of "Flood"

    ERIC Educational Resources Information Center

    Kilinc, Yusuf

    2013-01-01

    The aim of this research is to define and explain how high school students in Turkey perceive the concept of "Flood". The study was completed by 413 high-school students who were studying in 9th, 10th, 11th and 12th grade classes within the 2011 to 2012 academic years. Students were responsible for completing the statement, "Flood…

  8. Investigation of High School Students' Reading Compherension Levels According to Various Variables

    ERIC Educational Resources Information Center

    Ceran, Dilek

    2015-01-01

    The purpose of this study is to investigate the level of reading comprehension of high school students in their fields of study and learning strategies to explain the relationship between the level of reading comprehension. This working group is composed of 11th grade high school students. In this study, relational model was used. In the study…

  9. HIGH FREQUENCY ULTRASOUND OF ARMOR-GRADE ALUMINA CERAMICS

    SciTech Connect

    Bottiglieri, S.; Haber, R. A.

    2009-03-03

    Different lots of high density, commercial, armor-grade alumina (Al{sub 2}O{sub 3}) were tested using high frequency ultrasound in order to determine any correlation between measured properties and ballistic performance. C-scan images were taken using a 15 MHz ultrasonic transducer in order to form attenuation coefficient and elastic property maps. These samples were further characterized by using quantitative analysis. The results indicate that attenuation coefficient values appear to have the strongest correlation, of every property measured, to ballistic classifications.

  10. High temperature tensile deformation behavior of Grade 92 steel

    NASA Astrophysics Data System (ADS)

    Alsagabi, Sultan; Shrestha, Triratna; Charit, Indrajit

    2014-10-01

    Candidate structural materials for advanced reactors need to have superior high temperature strength and creep-rupture properties among other characteristics. The ferritic-martensitic Grade 92 steel (Fe-9Cr-2W-0.5Mo, wt.%) is considered such a candidate structural material. Tensile tests were performed at temperatures of 600, 650 and 700 °C in the strain rate range of 10-5-10-3 s-1. After analyzing the tensile results using the Bird-Mukherjee-Dorn (BMD) equation, a stress exponent of about 9.5 and an activation energy of about 646 kJ/mol were obtained. In the light of high values of the stress exponent and activation energy, the threshold stress concept was used to elucidate the operating high temperature deformation mechanism. As a result of this modification, the true activation energy and stress exponent of the high temperature deformation in Grade 92 steel were found to be about 245 kJ/mol and 5, respectively. Thus, the dominant high temperature deformation mechanism was identified as the high temperature climb of edge dislocations and the appropriate constitutive equation was developed.

  11. Entheseal changes and sexual division of labor in a North-African population: The case of the pre-Hispanic period of the Gran Canaria Island (11th-15th c. CE).

    PubMed

    Santana-Cabrera, J; Velasco-Vázquez, J; Rodríguez-Rodríguez, A

    2015-04-01

    The aim of this paper is to investigate the relationship between entheseal changes and sexual division of labor in the pre-Hispanic population of Gran Canaria Island (Spain). Ethnohistorical records from the period of contact between Europeans and the Canarian indigenous population provide rich information about the different activities performed by men and women. For this purpose, entheseal changes in a sample of 138 individuals (82 males and 56 females) buried in ten pre-Hispanic cemeteries (11th and 15th centuries cal. CE) were analyzed. Forty-one entheses located in the clavicle, humerus, ulna and radius were analyzed (fibrous and fibro-cartilaginous attachment sites). Entheses were graded using a visual and descriptive standard which summarized the entheseal changes. This method interprets the changes as a sign of robustness on a scale from low to high development and includes enthesopathies. The intra- and inter-observer error of this method was minimal. Sex differences in the degree of robustness, bilateral asymmetry, sexual dimorphism and principal components analyses were tested in this sample. The results indicate significant variance in the entheseal robustness between males and females. They also suggest the impact of certain biomechanical chains (pronosupination, shoulder rotation, etc.) in entheseal changes. These results contribute to an interdisciplinary approach to the study of the sexual division of labor in the pre-Hispanic society of Gran Canaria. PMID:25701082

  12. Remembering September 11th: the role of retention interval and rehearsal on flashbulb and event memory.

    PubMed

    Shapiro, Lauren R

    2006-02-01

    Retention interval and rehearsal effects on flashbulb and event memory for 11th September 2001 (9/11) were examined. In Experiment 1, college students were assessed three times (Groups 1 and 2) or once (Group 3) over 11 weeks. In Experiment 2, three new groups assessed initially at 23 weeks (Group 4), 1 year (Group 5), or 2 years (Group 6) were compared at 1 year and at 2 years with subsamples of those assessed previously. No effects of retention interval length or rehearsal were found for flashbulb memory, which contained details at each assessment. Event memory, but not consistency, was detrimentally affected by long retention intervals, but improved with rehearsal. Recall was higher for the reception event than for the main events. Also, consistency from 1 day to 11 weeks, but not 1 year to 2 years, was higher for flashbulb memory than for event memory. Event recall was enhanced when respondents conceived of their memory as vivid, frozen, and encompassing a longer period of time. Positive correlations were found for event memory with confidence in accuracy and with rehearsal through discussion at 2 years. PMID:16484105

  13. Differences in Risk Factors for Suicide Attempts Among 9th and 11th Grade Youth: A Longitudinal Perspective

    ERIC Educational Resources Information Center

    Fried, Lise E.; Williams, Sandra; Cabral, Howard; Hacker, Karen

    2013-01-01

    The purpose of the study is to assess the relationship between timing of adolescent development and risk factors for suicide. Nationally representative data from the Add Health survey were used. The relationship of sociodemographic characteristics, known risk factors, and physical developmental timing and cognitive developmental style to suicide…

  14. High grade abrasive product development from virtified industrial waste

    SciTech Connect

    Blume, R.D.; Drummond, C.H. III; Sarko, A.

    1996-12-31

    Recent developments in environmental legislation, as well as economic incentives such as the increasing cost of landfilling, have led to a paradigm shift away from encapsulation of hazardous waste. The current focus is recycling and product development utilizing industrial waste as raw materials. Current research has targeted the development of high grade abrasive (Vickers hardness (VHN) > 1000 kgF/mm{sup 2}) for blasting and buffing and polishing applications. In addition to product specific physical properties, the developed formulations must also have processing characteristics necessary for vitrification using a high temperature product burner developed by Seiler Pollution Control Systems, as well as the necessary resistance to leaching of EPA regulated hazardous components. Current work has led to the development of formulations with high VHN (950 kgF/mm{sup 2}), acceptable chemical durability, and high mechanical durability utilizing electric arc furnace dust (KO61) and foundry sand as the major components.

  15. Moderating Effect of Age on the Link of Emotional Intelligence and Mental Health among High School Students

    ERIC Educational Resources Information Center

    Shabani, Jafar; Hassan, Siti Aishah; Ahmad, Aminah; Baba, Maznah

    2011-01-01

    This study examined whether Emotional Intelligence (EI) can be considered as predictor for mental health and explored also the moderating effect of age on the link between EI with mental health among high school students. The participants in the study included 10th, 11th, and 12th grade students from 8 public high schools in Gorgan City, north of…

  16. Would Einstein Be Proficient? A Study of High School Science Course Sequencing and Proficiency on FCAT Science

    ERIC Educational Resources Information Center

    Nearor, Nicole D.

    2012-01-01

    The main focus of this study was to investigate if, or to what extent, there is a significant relationship between high school science course sequencing and proficiency on 11th grade Florida Comprehensive Assessment Test (FCAT) Science. The Florida Legislature mandated a specific number of sciences as a requirement for graduation. High schools…

  17. The Psychosocial Factors Contributing to the Underrepresentation of African American Males in Advanced High School Mathematics Courses

    ERIC Educational Resources Information Center

    Rowlett, Joel Everett

    2013-01-01

    This case study examined the beliefs of African American males on the psychosocial and pedagogical factors contributing to the underrepresentation of African American males in advanced high school math courses. Six 11th grade African American male juniors from a large, comprehensive, Southeastern high school served as individual cases. Within- and…

  18. Looking Forward to High School and College: Middle Grade Indicators of Readiness in Chicago Public Schools

    ERIC Educational Resources Information Center

    Allensworth, Elaine M.; Gwynne, Julia A.; Moore, Paul; de la Torre, Marisa

    2014-01-01

    There is a very large population of students who struggle with the transition from the middle grades to high school, raising concerns that high school failures are partially a function of poor middle grade preparation. As a result, middle grade practitioners are grappling with questions about what skills students need to succeed in high school,…

  19. Genomic characterization of recurrent high-grade astroblastoma.

    PubMed

    Bale, Tejus A; Abedalthagafi, Malak; Bi, Wenya Linda; Kang, Yun Jee; Merrill, Parker; Dunn, Ian F; Dubuc, Adrian; Charbonneau, Sarah K; Brown, Loreal; Ligon, Azra H; Ramkissoon, Shakti H; Ligon, Keith L

    2016-01-01

    Astroblastomas are rare primary brain tumors, diagnosed based on histologic features. Not currently assigned a WHO grade, they typically display indolent behavior, with occasional variants taking a more aggressive course. We characterized the immunohistochemical characteristics, copy number (high-resolution array comparative genomic hybridization, OncoCopy) and mutational profile (targeted next-generation exome sequencing, OncoPanel) of a cohort of seven biopsies from four patients to identify recurrent genomic events that may help distinguish astroblastomas from other more common high-grade gliomas. We found that tumor histology was variable across patients and between primary and recurrent tumor samples. No common molecular features were identified among the four tumors. Mutations commonly observed in astrocytic tumors (IDH1/2, TP53, ATRX, and PTEN) or ependymoma were not identified. However one case with rapid clinical progression displayed mutations more commonly associated with GBM (NF1(N1054H/K63)*, PIK3CA(R38H) and ERG(A403T)). Conversely, another case, originally classified as glioblastoma with nine-year survival before recurrence, lacked a GBM mutational profile. Other mutations frequently seen in lower grade gliomas (BCOR, BCORL1, ERBB3, MYB, ATM) were also present in several tumors. Copy number changes were variable across tumors. Our findings indicate that astroblastomas have variable growth patterns and morphologic features, posing significant challenges to accurate classification in the absence of diagnostically specific copy number alterations and molecular features. Their histopathologic overlap with glioblastoma will likely confound the observation of long-term GBM "survivors". Further genomic profiling is needed to determine whether these tumors represent a distinct entity and to guide management strategies. PMID:27425854

  20. Examining Scientific and Technical Writing Strategies in the 11th Century Chinese Science Book "Brush Talks from Dream Brook"

    ERIC Educational Resources Information Center

    Zhang, Yuejiao

    2013-01-01

    This article examines the influential Chinese science book "Brush Talks from Dream Brook," written by Shen Kuo in the 11th century. I suggest that "Brush Talks" reveals a tension between institutionalized science and science in the public, and a gap between the making of scientific knowledge and the communication of such…

  1. Using ARCS Model to Promote 11th Graders' Motivation and Achievement in Learning about Acids and Bases

    ERIC Educational Resources Information Center

    Feng, Sung-Lin; Tuan, Hsiao-Lin

    2005-01-01

    The purposes of this study are: to apply the ARCS model in designing an acid and bases unit, and to assess a single class of 11th graders for motivation and achievement outcomes before and after ARCS instruction. Four essential strategies for designing motivation instruction in the ARCS model were: Attention, Relevance, Confidence, and…

  2. 11th Annual Comparative Analysis of the Racine Unified School District: Demographics, Attendance, Finances, Student Engagement, and Achievement

    ERIC Educational Resources Information Center

    Public Policy Forum, 2008

    2008-01-01

    This is the 11th annual report on conditions affecting the Racine Unified School District (RUSD). Analysis continues to focus on the long-term historical trends in RUSD, comparing RUSD to nine peer school districts and the State of Wisconsin. RUSD peer districts are Wisconsin's largest (Milwaukee Public Schools are not included) and their…

  3. Percutaneous coronary intervention for coronary bifurcation disease: 11th consensus document from the European Bifurcation Club.

    PubMed

    Lassen, Jens Flensted; Holm, Niels Ramsing; Banning, Adrian; Burzotta, Francesco; Lefèvre, Thierry; Chieffo, Alaide; Hildick-Smith, David; Louvard, Yves; Stankovic, Goran

    2016-05-17

    Coronary bifurcations are involved in 15-20% of all percutaneous coronary interventions (PCI) and remain one of the most challenging lesions in interventional cardiology in terms of procedural success rate as well as long-term cardiac events. The optimal management of bifurcation lesions is, despite a fast growing body of scientific literature, the subject of considerable debate. The European Bifurcation Club (EBC) was initiated in 2004 to support a continuous overview of the field, and aims to facilitate a scientific discussion and an exchange of ideas on the management of bifurcation disease. The EBC hosts an annual, compact meeting, dedicated to bifurcations, which brings together physicians, engineers, biologists, physicists, epidemiologists and statisticians for detailed discussions. Every meeting is finalised with a consensus statement which reflects the unique opportunity of combining the opinions of interventional cardiologists with the opinions of a large variety of other scientists on bifurcation management. The present 11th EBC consensus document represents the summary of the up-to-date EBC consensus and recommendations. It points to the fact that there is a multitude of strategies and approaches to bifurcation stenting within the provisional strategy and in the different two-stent strategies. The main EBC recommendation for PCI of bifurcation lesions remains to use main vessel (MV) stenting with a proximal optimisation technique (POT) and provisional side branch (SB) stenting as a preferred approach. The consensus document covers a moving target. Much more scientific work is needed in non-left main (LM) and LM bifurcation lesions for continuous improvement of the outcome of our patients. PMID:27173860

  4. Social Science Instructional Guides: High School (Grades 9-12).

    ERIC Educational Resources Information Center

    Hartman, Carl; And Others

    The guide, part of a social science learning continuum from first through twelfth grades, contains outlines for two-semester social studies courses for grades 9-12. Three components comprise each section: time allocations for units, instructional objectives, and a content outline. The Grade 9 course, Cultures of the Non-Western World, contains…

  5. An Analysis of High School Students' Concepts & Textbook Presentations of Food Chains & Food Webs.

    ERIC Educational Resources Information Center

    Barman, Charles R.; Mayer, Deborah A.

    1994-01-01

    A qualitative investigation involving 11th- and 12th-grade high school students was conducted to determine whether U.S. students demonstrate the same level of difficulty as previously tested Canadian, Nigerian, and Scottish students regarding the following concepts: energy transfer among organisms and the interrelationships that exist between the…

  6. Civilization III and Whole-Class Play in High School Social Studies

    ERIC Educational Resources Information Center

    Lee, John K.; Probert, Jeffrey

    2010-01-01

    This study examined an 11th grade high school class as they played the game Civilization III. Over nine class sessions students played the game in support of other activities related to several predetermined and emergent topics in U. S. history. Gameplay was whole-class oriented and involved students taking turns at the computer controlling…

  7. An Electrical Engineering Summer Academy for Middle School and High School Students

    ERIC Educational Resources Information Center

    LoPresti, Peter G.; Manikas, Theodore W.; Kohlbeck, Jeff G.

    2010-01-01

    An Electrical Engineering Summer Academy for Pre-College Students was held at the University of Tulsa, Tulsa, OK, during the summers of 2007 and 2008. The Academy participants included students having just completed 7th to 11th grade and teachers from middle school through high school. The students and teachers participated in team-building,…

  8. Assessing Earth and Environmental Science Enrollment Trends in Texas Public High Schools

    ERIC Educational Resources Information Center

    Sanders, Joan G.

    2012-01-01

    Scope and Method of Study: This study assesses the status of Earth and environmental sciences education in Texas Public High Schools by analyzing enrollment proportions of 11th and 12th grade students in 607 Independent School Districts (ISD) for the 2010-2011 academic school year using a quantitative, non-experimental alpha research design. This…

  9. High-Stakes Accountability: Student Anxiety and Large-Scale Testing

    ERIC Educational Resources Information Center

    von der Embse, Nathaniel P.; Witmer, Sara E.

    2014-01-01

    This study examined the relationship between student anxiety about high-stakes testing and their subsequent test performance. The FRIEDBEN Test Anxiety Scale was administered to 1,134 11th-grade students, and data were subsequently collected on their statewide assessment performance. Test anxiety was a significant predictor of test performance…

  10. Is Coca Paste Currently a Drug of Abuse among High School Students?

    ERIC Educational Resources Information Center

    Huba, George J.; And Others

    1981-01-01

    Studied the use of the drug coca paste by high school students in Los Angeles. Of 11th- and 12th-grade males (N=228), four claimed to have recently used coca paste, and of (N=460) females, five reported using the drug. Also studied comparative usage with other substances, and attitudes. (Author/RC)

  11. Motivational Correlates of Portuguese High Schoolers' Vocational Identity: Cultural Validation of the Goal Instability Scale

    ERIC Educational Resources Information Center

    Santos, Paulo Jorge; Casillas, Alex; Robbins, Steven B.

    2004-01-01

    This study examined the relevance of the Goal Instability Scale-Portuguese Adaptation (GIS-P) on the vocational identity and career certainty of 375 10th-, 11th-, and 12th-grade Portuguese high schoolers. After translating the GIS-P, confirmatory factor analysis was used to examine the factorial unidimensionality and reliability of the construct.…

  12. PROJECT TALENT--IDENTIFICATION, DEVELOPMENT AND UTILIZATION OF HUMAN TALENTS, REPORT OF THE ELEVENTH-GRADE FOLLOW-UP STUDY.

    ERIC Educational Resources Information Center

    COOLEY, WILLIAM W.; FLANAGAN, JOHN C.

    QUESTIONNAIRE FORMS WERE SENT TO 98,000 11TH-GRADE STUDENTS IN 1960, AND 45,199 COMPLETED FORMS WERE RETURNED. OF THOSE RESPONDENTS QUESTIONED, 91 PERCENT GRADUATED FROM HIGH SCHOOL AND 1 PERCENT EXPECTED TO GRADUATE LATER. AFTER GRADUATION 45.5 PERCENT DID NOT CONTINUE IN ANY TYPE OF SCHOOL, WHILE 38.5 PERCENT ENTERED COLLEGE. THERE WERE 7…

  13. The Importance of the Ninth Grade on High School Graduation Rates and Student Success

    ERIC Educational Resources Information Center

    McCallumore, Kyle Megan; Sparapani, Ervin F.

    2010-01-01

    Researchers target 9th grade as the make or break year for completing high school. During the 9th-grade year, many students for the first time have to earn passing grades in core courses, and these core courses are typically some of the toughest and most rigorous academic classes a student must take in high school. Furthermore, the rising use of…

  14. High grade neuroendocrine neoplasm of the antrum and orbit.

    PubMed

    MacIntosh, Peter W; Jakobiec, Frederick A; Stagner, Anna M; Gilani, Sapideh; Fay, Aaron

    2015-01-01

    Neuroendocrine malignancies-tumors characterized by the production of dense-core secretory granules-are most often encountered in the lungs and can also be found in extrapulmonary sites. Our patient had a primary neuroendocrine tumor of the antrum with an elusive cell of origin that secondarily invaded the inferior orbit. In the sinuses, neuroendocrine tumors may be confused with infectious sinusitis or squamous cell carcinoma. There are no known pathognomonic clinical or radiographic signs to distinguish these tumors from other conditions. Diagnosis depends on a biopsy with histopathologic and immunohistochemical analysis to identify biomarkers such as synaptophysin, chromogranin, CD56 and neuron specific enolase. Our patient's tumor defied precise immunohistochemical characterization because of its primitive character and erratic biomarker expression. The diagnosis oscillated between a neuroendocrine carcinoma and an ectopic esthesioneuroblastoma grade IV-hence the use of the more generic nosologic category of neuroendocrine neoplasm without specifying a neuronal or epithelial origin. Data to guide management are limited, particularly in the ophthalmic literature, and derive from experience with tumors of the sinonasal compartments. In the present case of a sino-orbital high grade neuroendocrine neoplasm, regional lymph node metastases developed shortly after presentation. The tumor has responded well to chemotherapy and radiation, but recurrence is often encountered within 2 years in this class of neoplasms. PMID:26077631

  15. Yoga May Mitigate Decreases in High School Grades

    PubMed Central

    Butzer, Bethany; van Over, Max; Noggle Taylor, Jessica J.; Khalsa, Sat Bir S.

    2015-01-01

    This study involves an exploratory examination of the effects of a 12-week school-based yoga intervention on changes in grade point average (GPA) in 9th and 10th grade students. Participants included 95 high school students who had registered for physical education (PE) in spring 2010. PE class sections were group randomized to receive either a yoga intervention or a PE-as-usual control condition. The yoga intervention took place during the entire third quarter and half of the fourth quarter of the school year, and quarterly GPA was collected via school records at the end of the school year. Results revealed a significant interaction between group and quarter suggesting that GPA differed between the yoga and control groups over time. Post hoc tests revealed that while both groups exhibited a general decline in GPA over the school year, the control group exhibited a significantly greater decline in GPA from quarter 1 to quarter 3 than the yoga group. Both groups showed equivalent declines in GPA in quarter 4 after the yoga intervention had ended. The results suggest that yoga may have a protective effect on academic performance by preventing declines in GPA; however these preventive effects may not persist once yoga practice is discontinued. PMID:26347787

  16. Positron emission tomography of high-grade gliomas.

    PubMed

    Frosina, Guido

    2016-05-01

    High-grade gliomas [HGG (WHO grades III-IV)] are almost invariably fatal. Imaging of HGG is important for orientating diagnosis, prognosis and treatment planning and is crucial for development of novel, more effective therapies. Given the potentially unlimited number of usable tracing molecules and the elevated number of available radionuclides, PET allows gathering multiple informations on HGG including data on tissue metabolism and drug pharmacokinetics. PET studies on the diagnosis, prognosis and treatment of HGG carried out by most frequently used tracers and radionuclides ((11)C and (18)F) and published in 2014 have been reviewed. These studies demonstrate that a thorough choice of tracers may confer elevated diagnostic and prognostic power to PET imaging of HGG. They also suggest that a combination of PET and MRI may give the most complete and reliable imaging information on HGG and that research on hybrid PET/MRI may be paying back in terms of improved diagnosis, prognosis and treatment planning of these deadly tumours. PMID:26897013

  17. Yoga May Mitigate Decreases in High School Grades.

    PubMed

    Butzer, Bethany; van Over, Max; Noggle Taylor, Jessica J; Khalsa, Sat Bir S

    2015-01-01

    This study involves an exploratory examination of the effects of a 12-week school-based yoga intervention on changes in grade point average (GPA) in 9th and 10th grade students. Participants included 95 high school students who had registered for physical education (PE) in spring 2010. PE class sections were group randomized to receive either a yoga intervention or a PE-as-usual control condition. The yoga intervention took place during the entire third quarter and half of the fourth quarter of the school year, and quarterly GPA was collected via school records at the end of the school year. Results revealed a significant interaction between group and quarter suggesting that GPA differed between the yoga and control groups over time. Post hoc tests revealed that while both groups exhibited a general decline in GPA over the school year, the control group exhibited a significantly greater decline in GPA from quarter 1 to quarter 3 than the yoga group. Both groups showed equivalent declines in GPA in quarter 4 after the yoga intervention had ended. The results suggest that yoga may have a protective effect on academic performance by preventing declines in GPA; however these preventive effects may not persist once yoga practice is discontinued. PMID:26347787

  18. PREFACE: 11th International Spring Seminar on Nuclear Physics: Shell Model and Nuclear Structure - achievements of the past two decades

    NASA Astrophysics Data System (ADS)

    2015-02-01

    The 11th International Seminar on Nuclear Physics was held in Ischia from May 12 to May 16, 2014. This Seminar was dedicated to Aldo Covello, who has been the promoter of this series of meetings, which started in Sorrento in 1986 and continued with meetings held every two or three years in the Naples area. Aldo's idea was to offer to a group of researchers, actively working in selected fields of Nuclear Physics, the opportunity to confront their points of view in a lively and informal way. The choice for the period of the year, Spring, as well as the sites chosen reflected this intent. The first meeting was of a purely theoretical nature, but it was immediately clear that the scope of these conferences needed to be enlarged calling into play the experimental community. Then, starting from the second meeting, all the following ones have been characterized by fruitful discussion between theoretical and experimental researchers on current achievements and future developments of nuclear structure. This may be read, in fact, as one of the motivating factors for Aldo's election as Fellow of the American Physical Society in 2008 "... for his outstanding contributions to the international nuclear physics community by providing, for over two decades, a venue for theorists and experimentalists to share their latest ideas." The present meeting, organized by Aldo's former students and with the benefit of his suggestions, has maintained this tradition. The title "Shell model and nuclear structure: achievements of the past two decades" recalls that of the 2nd International Spring Seminar "Shell Model and Nuclear Structure: where do we stand?". The main aim of this 11th Seminar was, in fact, to discuss the changes of the past two decades on our view of nuclei in terms of shell structure as well as the perspectives of the shell model, which has been one of the key points in Aldo's research. This point is well accounted by the Opening Speech of Igal Talmi, one of the fathers of the

  19. Neoadjuvant chemotherapy for high-grade advanced gastric cancer.

    PubMed

    Yonemura, Y; Sawa, T; Kinoshita, K; Matsuki, N; Fushida, S; Tanaka, S; Ohoyama, S; Takashima, T; Kimura, H; Kamata, T

    1993-01-01

    Fifty-five patients with high-grade advanced gastric cancer in whom the presence of stage IV was confirmed by preoperative diagnostic imaging were treated with PMUE therapy by a combined use of cisplatin (CDDP) 75 mg/m2, mitomycin C (MMC) 10 mg/body, etoposide 150 mg/body, and UFT (a combination of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil in a molar ratio of 1:4) 400 mg/day. CDDP and MMC was administered intravenously on the first day, followed by etoposide 50 mg/day on the 3rd, 4th, and 5th days. All the patients had measurable lesions that were evaluated by computed tomography scanning before and after the treatments. These patients were allocated randomly to two groups. Of these cases, 29 belonged to the neoadjuvant chemotherapy (NAC) group to whom PMUE therapy was given preoperatively; the remaining 26 patients underwent operation first and received PMUE thereafter (control group). Background factors did not differ significantly between the two groups. The response rate was higher in the NAC group than in the control group (62% in the former versus 35% in the latter). The resectability rates were 79% and 88% in the NAC and control groups, respectively. However, the rate of potentially curable cases was higher in the NAC group than in the control group (38% in the former versus 15% in the latter). Among the nonresection cases, the prognosis was highly unfavorable in both groups. In the resection cases, however, the survival rate was significantly better in the NAC group than in the control group. These results may indicate that in patients with high-grade, advanced gastric cancer initial chemotherapy (neoadjuvant chemotherapy) and then surgery should be considered. PMID:8511923

  20. Assessment of China's Energy-Saving and Emission-Reduction Accomplishments and Opportunities During the 11th Five Year Plan

    SciTech Connect

    Levine, Mark D.; Price, Lynn; Zhou, Nan; Fridley, David; Aden, Nathaniel; Lu, Hongyou; McNeil, Michael; Zheng, Nina; Yining, Qin; Yowargana, Ping

    2010-04-28

    During the period 1980 to 2002, China experienced a 5% average annual reduction in energy consumption per unit of gross domestic product (GDP). The period 2002-2005 saw a dramatic reversal of the historic relationship between energy use and GDP growth: energy use per unit of GDP increased an average of 3.8% per year during this period (NBS, various years). China's 11th Five Year Plan (FYP), which covers the period 2006-2010, required all government divisions at different levels to reduce energy intensity by 20% in five years in order to regain the relationship between energy and GDP growth experienced during the 1980s and 1990s. This report provides an assessment of selected policies and programs that China has instituted in its quest to fulfill the national goal of a 20% reduction in energy intensity by 2010. The report finds that China has made substantial progress toward its goal of achieving 20% energy intensity reduction from 2006 to 2010 and that many of the energy-efficiency programs implemented during the 11th FYP in support of China's 20% energy/GDP reduction goal appear to be on track to meet - or in some cases even exceed - their energy-saving targets. It appears that most of the Ten Key Projects, the Top-1000 Program, and the Small Plant Closure Program are on track to meet or surpass the 11th FYP savings goals. China's appliance standards and labeling program, which was established prior to the 11th FYP, has become very robust during the 11th FYP period. China has greatly enhanced its enforcement of new building energy standards but energy-efficiency programs for buildings retrofits, as well as the goal of adjusting China's economic structure to reduce the share of energy consumed by industry, do not appear to be on track to meet the stated goals. With the implementation of the 11th FYP now bearing fruit, it is important to maintain and strengthen the existing energy-saving policies and programs that are successful while revising programs or adding new

  1. PREFACE: 11th International Workshop on Positron and Positronium Chemistry (PPC-11)

    NASA Astrophysics Data System (ADS)

    Pujari, P. K.; Sudarshan, K.; Dutta, D.

    2015-06-01

    The International Workshop on Positron and Positronium Chemistry (PPC) is a prestigious triennial conference series with a rich history. The 11th meeting in the series (PPC-11) was held at Cidade de Goa, Goa, India during 9-14, November, 2014. It was organized by Bhabha Atomic Research Centre (BARC), Mumbai. The co-organizers were Saha Institute of Nuclear Physics (SINP), Kolkata, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam and Indian Association of Nuclear Chemists and Allied Scientists (IANCAS), Mumbai. PPC-11 attracted participants both from academic institutions and industries. About 120 participants from 20 countries representing all continents participated in the conference. The conference continued the tradition of excellence in terms of quality of presentations and discussions. There were 33 plenary and invited talks, 39 oral presentations and 40 posters. The conference stood true to its multidisciplinary tag with papers presented in the fields of fundamentals of positron and positronium chemistry, applications in polymers, porous materials, metals/alloys, studies in liquids, biological applications as well as developments in theory and experimental techniques. The enthusiastic participation of senior researchers and young students made the scientific program a grand success. In order to encourage the student participants (twenty) and promote excellence, a committee of senior members evaluated their presentations and the top three contributions were awarded. The positron and positronium community paid homage to the memory of late Profs. J. Kristiak and A.T. Stewart. A brief sketch of their life and work was presented by Profs. Jan Kuriplach and Toshio Hyodo, respectively. All the papers published in these proceedings have been peer reviewed by the participants of PPC-11. Editors thank all the reviewers for sparing their valuable time and helping us in bringing out the proceedings with 43 contributed articles in the scheduled time. We are

  2. Selected papers from the 11th European Conference on Applied Superconductivity (EUCAS 2013)

    NASA Astrophysics Data System (ADS)

    Ferdeghini, Carlo; Putti, Marina

    2014-04-01

    The 11th edition of the European Conference on Applied Superconductivity (EUCAS) was held in Genoa (15-19 September 2013) and registered the participation of more than one thousand attendants from over 40 countries. During the conference seven plenary lectures, 23 invited, and 203 oral contributions and 550 posters have been presented, all focused on recent developments in the field of superconductivity applications. This issue of Superconductor Science Technology is a collection of some of the plenary and invited contributions. Moreover, the winners of the EUCAS prizes (the electronics prize dedicated to the memory of Antonio Barone), and the most significant oral contributions selected by the 125 chairs involved in the organization, have been invited to submit their papers. The remaining papers presented at the conference will be published in the Journal Physics Conference Series, edited by S Farinon, G Lamura, A Malagoli and I Pallecchi. The papers have been organized into the four traditional topics of interest of EUCAS, namely materials, wires and tapes, large scale applications, and electronics. The plenary lectures on these four topics have been collected: Potential of iron-based superconductors for practical materials in the future (J Shimoyama), Coated conductors for power applications: materials challenges (J Obradors), Challenges and status of ITER conductor production (A Devred), and the Impact of superconducting devices in imaging in neuroscience (G L Romani). We hope that this issue will let you taste the flavours, hear the sounds and see the colours of this exciting EUCAS edition. The very large participation in EUCAS 2013 has allowed debates on a wide range of topics, starting from the most basic studies on emergent materials up to the new developments in electronics and large scale applications. A round table on HTS Conductors was experimented for the first time gathering material scientists, wire manufacturers and device builders in a stimulating

  3. Using Cognitive Counseling To Provide Learning Disabled Students with Skills Necessary To Transition from High School to College.

    ERIC Educational Resources Information Center

    Weiss, Ira

    The practicum reported here was designed to address the problem of a group of six college-bound 11th- and 12th-grade learning disabled students who attended a high school that did not have in place a program that would prepare them for the transition from secondary school to college. The intervention used cognitive techniques to raise the…

  4. Leaks in nuclear grade high efficiency aerosol filters

    SciTech Connect

    Scripsick, R.C.

    1994-07-01

    Nuclear grade high efficiency aerosol filters, also known as high efficiency particulate air (HEPA) filters, are commonly used in air cleaning systems for removal of hazardous aerosols. Performance of the filter units is important in assuring health and environmental protection. The filter units are constructed from pleated packs of fiberglass filter media sealed into rigid frames. Results of previous studies on such filter units indicate that their performance may not be completely predicted by ideal performance of the fibrous filter media. In this study, departure from ideal performance is linked to leaks existing in filter units and overall filter unit performance is derived from independent performance of the individual filter unit components. The performance of 14 nuclear grade HEPA filter units (size 1, 25 cfm) with plywood frames was evaluated with a test system that permitted independent determination of penetration as a function of particle size for the whole filter unit, the filter unit frame, and the filter media pack. Tests were performed using a polydisperse aerosol of di-2-ethylhexyl phthalate with a count median diameter of 0.2 {mu}m and geometric standard deviation of 1.6. Flow rate and differential pressure were controlled from 1% to 100% of design values. Particle counts were made upstream and downstream of the filter unit with an optical particle counter (OPC). The OPC provided count information in 28 size channels over the particle diameter range from 0.1 to 0.7 {mu}m. Results provide evidence for a two component leak model of filler unit performance with: (1) external leaks through filter unit frames, and (2) internal leaks through defects in the media and through the seal between the media pack and frame. For the filter units evaluated, these leaks dominate overall filter unit performance over much of the flow rate and particle size ranges tested.

  5. Moral Aspects of Grading: A Study of High School English Teachers' Perceptions

    ERIC Educational Resources Information Center

    Zoeckler, Laurence G.

    2007-01-01

    Moral issues embedded in grading practices of high school English teachers are central to this study. Arriving at a fair grade while weighing both achievement and non-achievement factors and the role of teachers' expectations are examined using a theoretical framework which considers grading processes in terms of truth, worthwhileness, trust, and…

  6. Discrimination against Students with Foreign Backgrounds: Evidence from Grading in Swedish Public High Schools

    ERIC Educational Resources Information Center

    Hinnerich, Bjorn Tyrefors; Höglin, Erik; Johannesson, Magnus

    2015-01-01

    We rigorously test for discrimination against students with foreign backgrounds in high school grading in Sweden. We analyse a random sample of national tests in the Swedish language graded both non-blindly by the student's own teacher and blindly without any identifying information. The increase in the test score due to non-blind grading is…

  7. Campus Computing, 2000: The 11th National Survey of Computing and Information Technology in American Higher Education.

    ERIC Educational Resources Information Center

    Green, Kenneth C.

    The 2000 Campus Computing Survey, the 11th such survey, was sent to the chief academic officer at 1,176 two-year and four-year colleges and universities across the United States. By October 2000, 506 responses had been received, a response rate of 43%. New data reveal that the growing demand for technology talent across all sectors of the U.S.…

  8. Incorporating Ninth-Grade PSAT/NMSQT® Scores into AP Potential™ Predictions for AP® European History and AP World History. Statistical Report 2014-1

    ERIC Educational Resources Information Center

    Zhang, Xiuyuan; Patel, Priyank; Ewing, Maureen

    2015-01-01

    Historically, AP Potential™ correlations and expectancy tables have been based on 10th-and 11th-grade PSAT/NMSQT® examinees and 11th-and 12th-grade AP® examinees for all subjects (Zhang, Patel, & Ewing,2014; Ewing, Camara, & Millsap, 2006; Camara & Millsap, 1998). However, a large number of students take AP European History and AP…

  9. Estimating the Effects of September 11th and Other Forms of Violence on the Mental Health and Social Development of New York City's Youth: A Matter of Context

    ERIC Educational Resources Information Center

    Aber, J. Lawrence; Gershoff, Elizabeth T.; Ware, Angelica; Kotler, Jennifer A.

    2004-01-01

    This longitudinal study examines the effects of exposure to the terrorist attack of September 11th as well as exposure to other forms of community violence on change in the mental health and social attitudes of youths in New York City. Three quarters of the youths reported some form of direct exposure to the events of September 11th, and 80%…

  10. Surgical interventions for high grade vulval intraepithelial neoplasia

    PubMed Central

    Kaushik, Sonali; Pepas, Litha; Nordin, Andy; Bryant, Andrew; Dickinson, Heather O

    2014-01-01

    Background Vulval intraepithelial neoplasia (VIN) is a pre-malignant condition of the vulval skin. This uncommon chronic skin condition of the vulva is associated with a high risk of recurrence and the potential to progress to vulval cancer. The condition is complicated by its’ multicentric and multifocal nature. The incidence of this condition appears to be rising particularly in the younger age group. There is a lack of consensus on the optimal surgical treatment method. However, the rationale for surgical treatment of VIN has been to treat symptoms and exclude underlying malignancy with the continued aim of preservation of vulval anatomy and function. Repeated treatments affect local cosmesis and cause psychosexual morbidity thus impacting on the patients’ quality of life. Objectives To evaluate the effectiveness and safety of surgical interventions for high grade VIN. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), Issue 3, 2010, Cochrane Gynaecological Cancer Group Trials Register, MEDLINE and EMBASE up to September 2010. We also searched registers of clinical trials, abstracts of scientific meetings, reference lists of included studies and contacted experts in the field. Selection criteria Randomised controlled trials (RCTs) that compared surgical interventions, in adult women diagnosed with high grade vulval intraepithelial neoplasia. Data collection and analysis Two review authors independently abstracted data and assessed risk of bias. Main results We found only one RCT which included 30 women that met our inclusion criteria and this trial reported data on carbon dioxide laser (CO2 laser) versus ultrasonic surgical aspiration (USA). There was no statistically significant difference in the risk of disease recurrence after one year follow-up, pain, presence of scarring, dysuria or burning, adhesions, infection, abnormal discharge and eschar between women who received CO2 laser and those who received USA. The trial

  11. A Highly Miniaturized Inertial Grade Gyroscope for Space Applications

    NASA Technical Reports Server (NTRS)

    Wiberg, D. V.; Challoner, A. D.; Shcheglov, K.; Hayworth, K.; Bae, S.; Yee, K.; Blaes, B.; DAgostino, S.; Stock, T.

    2001-01-01

    The evolution of inertial grade gyroscopes for space applications represents well over 50 years of technology development and an investment of hundreds of millions of dollars. The workhorse product which represents the current state-of-the art for commercially available high performance devices is the Litton-Hemishperical Resonator Gyro (HRG) Inertial Measurement Unit (IMU). This product has a performance figure of merit of 0.003 deg/hr bias drift, a volume of 567 cubic inches, weighs 19 pounds, draws about 30 watts and costs over $1 million each. Clearly devices of this magnitude are not conducive to the minimized mass, volume, power, and cost constraints of outer planet missions. An approach to breaking these potential barriers is the use of Microelectromechanical Systems (MEMS) based inertial devices. Although substantially reduced in size, mass power and cost, this approach has produced devices in the tactical performance range of greater than 1 deg/hour bias drift. This level of performance satisfies the preponderance of high market volume requirements such as automotive and tactical munitions but does not meet the limited market quantity requirements for the high precision space based market. Because of the very limited size of the space based market, there is little economic incentive for commercial fabricators of tactical grade devices to address the necessary performance improvements. The Jet Propulsion Laboratory (JPL) in conjunction with Boeing Space Systems (BSS) is addressing this void to satisfy our mutual requirements in this area. The project objective to is to achieve 0.01 deg/hr performance in an IMU which is less than 10 cubic inches in volume, weighs less than 0.5 pounds, draws less than 1 watt and is available in volume production for less than $2500. Reductions of this magnitude will be mission enabling capabilities for a variety of anticipated outer planet mission attributes such as autonomous control and docking, formation flying and robotic

  12. A Highly Miniaturized Inertial Grade Gyroscope for Space Applications

    NASA Astrophysics Data System (ADS)

    Wiberg, D. V.; Challoner, A. D.; Shcheglov, K.; Hayworth, K.; Bae, S.; Yee, K.; Blaes, B.; DAgostino, S.; Stock, T.

    2001-01-01

    The evolution of inertial grade gyroscopes for space applications represents well over 50 years of technology development and an investment of hundreds of millions of dollars. The workhorse product which represents the current state-of-the art for commercially available high performance devices is the Litton-Hemishperical Resonator Gyro (HRG) Inertial Measurement Unit (IMU). This product has a performance figure of merit of 0.003 deg/hr bias drift, a volume of 567 cubic inches, weighs 19 pounds, draws about 30 watts and costs over 1 million each. Clearly devices of this magnitude are not conducive to the minimized mass, volume, power, and cost constraints of outer planet missions. An approach to breaking these potential barriers is the use of Microelectromechanical Systems (MEMS) based inertial devices. Although substantially reduced in size, mass power and cost, this approach has produced devices in the tactical performance range of greater than 1 deg/hour bias drift. This level of performance satisfies the preponderance of high market volume requirements such as automotive and tactical munitions but does not meet the limited market quantity requirements for the high precision space based market. Because of the very limited size of the space based market, there is little economic incentive for commercial fabricators of tactical grade devices to address the necessary performance improvements. The Jet Propulsion Laboratory (JPL) in conjunction with Boeing Space Systems (BSS) is addressing this void to satisfy our mutual requirements in this area. The project objective to is to achieve 0.01 deg/hr performance in an IMU which is less than 10 cubic inches in volume, weighs less than 0.5 pounds, draws less than 1 watt and is available in volume production for less than 2500. Reductions of this magnitude will be mission enabling capabilities for a variety of anticipated outer planet mission attributes such as autonomous control and docking, formation flying and robotic

  13. PREFACE 11th Europhysical Conference on Defects in Insulating Materials (EURODIM 2010)

    NASA Astrophysics Data System (ADS)

    Kovács, László; Corradi, Gábor

    2010-11-01

    The Europhysical Conference on Defects in Insulating Materials, organized in the period 12-16 July 2010 in Pécs, Hungary by the Research Institute for Solid State Physics and Optics, Budapest and the Institute of Physics of the University of Pécs, was the 11th European conference in the alternate series of EURODIM and ICDIM. The first meeting in Argonne, USA in 1956 was dedicated to the field of color centers in alkali halide crystals. Since then the topic has been gradually extended to the real structure of oxides, halides, nitrides and other more complex insulators, and also to less ordered materials like glasses, ceramics and low-dimensional systems, as well as applications e.g. in radiology, non-linear optics, photonics and electronics. Recently the field covered includes the research and technology of defect-related phenomena in crystalline and amorphous wide band-gap bulk, layered and nano-materials. More than 200 colleagues from 31 countries in Europe, Asia, Africa and the Americas have participated in the conference. The program contained in addition to seven invited and three keynote talks 67 further oral presentations as well as some 200 poster contributions. The city of Pécs, a pearl of the Southern Danubia region, was proud of hosting the conference as one of the 2010 European Capitals of Culture, this status crowning a long urban history dating back to paleochristian times in the Roman province Pannonia. On behalf of the Organizing Committee signature László Kovács Conference Chair Conference Chair László Kovács Crystal Physics Department Research Institute for Solid State Physics and Optics Budapest, Hungary e-mail: eurodim2010@optics.szfki.kfki.hu Program Committee Gábor Corradi (Hungary) István Földvári (Hungary) Rob A. Jackson (UK) László Kovács (Hungary) Martin Nikl (Czech Republic) Anna Vedda (Italy) Andrea Watterich (Hungary) International Advisory Committee M.G. Blanchin (France)A. Lushchik (Estonia) F. Bridges (USA

  14. Spontaneous Steinbeck: The Influence of Arts Integration, Primarily Spontaneous Painting, on the Reader Response of High School Juniors to "The Grapes of Wrath"

    ERIC Educational Resources Information Center

    Klasek, Catherine Huey

    2010-01-01

    This paper addresses my experience with a group of 11th grade students and their reading of The Grapes of Wrath (1939, 2002) by John Steinbeck. I questioned how the application of visual arts integration strategies, specifically the use of spontaneously created paintings, might influence the reader responses of my high school junior-level…

  15. The Transition from Single-Sex to Coeducational High Schools: Effects on Multiple Dimensions of Self-Concept and on Academic Achievement.

    ERIC Educational Resources Information Center

    Marsh, Herbert W.; And Others

    1988-01-01

    Self-concept measures and state certificate program achievement grades were used to determine the effects on 7th through 11th graders in Sydney (Australia) of converting two single-sex high schools to coeducational institutions. Pre- to post-transition data were collected from 1982 to 1985. Coeducational organizations benefit self-concept, while…

  16. I Know Who I Am, Do You?: Identity and Academic Achievement of Successful African American Male Adolescents in an Urban Pilot High School in the United States

    ERIC Educational Resources Information Center

    Wright, Brian L.

    2011-01-01

    This study explores racial-ethnic identity and academic achievement of five young African American men in 11th and 12th grade in an urban pilot high school. Data gathered through individual and group interviews and a questionnaire were analyzed to understand how academically successful African American male adolescents interpret their social and…

  17. Teachers' Perceptions of the Instructional Leadership Role of the Principal in Implementing Effective Instructional Leadership Practices to Prepare Students for the Georgia High School Graduation Test

    ERIC Educational Resources Information Center

    Holyfield, Beverly R.

    2010-01-01

    The purpose of this study was to build upon Askins's 2002 research by examining the perceptions of Georgia educators as it relates to the instructional leadership role of the principal in helping 11th- and 12th-grade teachers adjust to the newly implemented Georgia Performance Standards and high-stakes testing. This study used qualitative-dominant…

  18. [The role of age and tumor grade in the choice of fractionation regimen in patients with high-grade gliomas].

    PubMed

    Izmaĭlov, T R; Pan'shin, G A; Datsenko, P V

    2012-01-01

    There are currently no conventional guidelines for radiotherapy in gliomas. The treatment program is mainly formed in accordance with tumor morphology and the "golden standard" of irradiation is still the traditional mode of fractionation with a single focal dose of 2 Gy and total focal dose (TFD) of 60 Gy. In this report the treatment results of 396 patients with morphologically verified grade 3-4 malignant brain tumors receiving conventional irradiation regimen and irradiation by medium-sized fractions were analyzed to form institutional guidelines. The standard fractionation mode with a single focal dose of 2 Gy is preferable in patients with grade 3 glioma or elderly patients (over 60 years). TFD increase to 60-62 Gy in grade 4 gliomas and 54-56 Gy in grade 3 gliomas grants a significant improve in overall survival. An increase of a single irradiation fraction to 3 Gy may be used for patients younger than 60 years. In these cases it is advisable to use the TFD of 45 Gy or more (TFD of equivalent regimen with a dose greater than 54 Gy). The mentioned fractionation regimens could be recommended for the use in clinical practice to improve the results of high-grade gliomas treatment. PMID:22888654

  19. High-Performance Slab-on-Grade Foundation Insulation Retrofits

    SciTech Connect

    Goldberg, Louise F.; Mosiman, Garrett E.

    2015-09-01

    A more accurate assessment of slab-on-grade foundation insulation energy savings than traditionally possible is now feasible. This has been enabled by advances in whole building energy simulation with 3-dimensional foundation modelling integration at each time step together with an experimental measurement of the site energy savings of SOG foundation insulation. Ten SOG insulation strategies were evaluated on a test building to identify an optimum retrofit insulation strategy in a zone 6 climate (Minneapolis, MN). The optimum insulation strategy in terms of energy savings and cost effectiveness consisted of two components: (a) R-20 XPS insulation above grade, and, (b) R-20 insulation at grade (comprising an outer layer of R-10 insulation and an interior layer of R-12 poured polyurethane insulation) tapering to R-10 XPS insulation at half the below-grade wall height (the lower half of the stem wall was uninsulated).

  20. Barrett's esophagus: management of high-grade dysplasia and cancer.

    PubMed

    Ruol, Alberto; Zaninotto, Giovanni; Costantini, Mario; Battaglia, Giorgio; Cagol, Matteo; Alfieri, Rita; Epifani, Magdalena; Ancona, Ermanno

    2004-03-01

    Esophagectomy remains the treatment of choice for the appropriate patient with Barrett's adenocarcinoma invading beyond the mucosa, without evidence of distant metastasis or invasion of adjacent organs. On the other hand, therapeutic management of patients with Barrett's high-grade dysplasia (HGD) or mucosal adenocarcinoma should be individualized, taking into account the patient's preferences, willingness to return for frequent endoscopic biopsies, and medical fitness to undergo esophagectomy. Surgery has to be considered the best treatment for HGD or superficial carcinoma, unless contraindicated by severe comorbidities, because it has proven to be the only treatment that is successful in curing the condition and preventing recurrent HGD or the development of invasive cancer. Nonsurgical treatment by photodynamic therapy or endoscopic mucosal resection may be a less invasive and organ-sparing option for elderly, poor-risk patients but it is still to be considered an investigational therapy that should only be conducted under a clinical trial protocol. Finally, intensive endoscopic biopsy surveillance of patients with HGD is another investigational option that may allow prompt treatment of cancer if it develops. However, few data document the safety of this observational approach. PMID:15013713

  1. Concurrent thermochemoradiotherapy for brain high-grade glioma

    NASA Astrophysics Data System (ADS)

    Ryabova, A. I.; Novikov, V. A.; Choinzonov, E. L.; Gribova, O. V.; Startseva, Zh. A.; Bober, E. E.; Frolova, I. G.; Baranova, A. V.

    2016-08-01

    Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermoche-moradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well. A complication, limited skin burn (II stage), was diagnosed in two cases and treated conservatively without treatment interruption. A month after thermochemoradiotherapy the results were as follows: complete regression was achieved in 4 cases, partial regression in 4 cases, stable disease in 14 cases and disease progression in 6 cases (one of them is pseudo-progression). After completing the adjuvant chemotherapy 2 more patients demonstrated complete response and 1 patient had disease progression. Introduction of local hyperthermia in multimodal therapy of malignant glioma does not impair the combined modality treatment tolerability of patients with malignant gliomas. A small number of studied patients and short follow-up time do not allow making reliable conclusions about the impact of local hyperthermia on the treatment outcomes; however, there is a tendency towards the increase in disease-free survival in the patients with newly diagnosed malignant gliomas.

  2. GRADE REORGANIZATION PREPARATORY TO THE ESTABLISHMENT OF THE FOUR YEAR COMPREHENSIVE HIGH SCHOOL.

    ERIC Educational Resources Information Center

    FRANKEL, EDWARD

    THIS REPORT IS AN EVALUATION OF A NEW YORK CITY HIGH SCHOOL GRADE REORGANIZATION PLAN WHICH REMOVED THE NINTH GRADE IN 38 JUNIOR HIGH SCHOOLS IN DISADVANTAGED AREAS AND TRANSFERRED THE STUDENTS TO EITHER ACADEMIC OR VOCATIONAL HIGH SCHOOLS. THE GOALS WERE TO ACHIEVE QUALITY INTEGRATED EDUCATION AND TO IMPROVE THE ETHNIC BALANCE OF THE HIGH…

  3. Prognostic Implication of Preoperative Behavior Changes in Patients with Primary High-Grade Meningiomas

    PubMed Central

    2014-01-01

    High-grade meningiomas are rare extra-axial tumors, frequently causing brain invasion and prominent brain edema. Patients harboring high-grade meningiomas occasionally present with behavior changes. Data about frequency and prognostic importance of preoperative behavior changes in patients with high-grade meningiomas is missing. 86 patients with primary high-grade meningiomas were analyzed. Statistical analysis was performed to determine correlation of preoperative behavior changes with tumor location, preoperative brain edema, tumor cleavability, tumor grade, Ki67 proliferation index, and microscopic brain invasion. Survival analysis was performed. 30 (34.9%) patients presented with preoperative behavior changes. These changes were more frequent with male patients (P = 0.066) and patients older than 55 years (P = 0.018). They correlated with frontal location (P = 0.013), tumor size (P = 0.023), microscopic brain invasion (P = 0.015), and brain edema (P = 0.006). Preoperative behavior changes did not correlate with duration of symptoms, tumor cleavability, tumor malignancy grade, and Ki67 proliferation index. They were not significantly related to overall survival or recurrence-free survival of patients with primary high-grade meningiomas. Preoperative behavior changes are frequent in patients harboring primary high-grade meningiomas. They correlate with tumor size, microscopic brain invasion, and brain edema. Preoperative behavior changes do not predict prognosis in patients with primary high-grade meningiomas. PMID:24578632

  4. Is the 10th and 11th Intercostal Space a Safe Approach for Percutaneous Nephrostomy and Nephrolithotomy?

    SciTech Connect

    Muzrakchi, Ahmed Al; Szmigielski, W. Omar, Ahmed J.S.; Younes, Nagy M.

    2004-09-15

    The aim of this study was to determine the rate of complications in percutaneous nephrostomy (PCN) and nephrolithotomy (PCNL) performed through the 11th and 10th intercostal spaces using our monitoring technique and to discuss the safety of the procedure. Out of 398 PCNs and PCNLs carried out during a 3-year period, 56 patients had 57 such procedures performed using an intercostal approach. The 11th intercostal route was used in 42 and the 10th in 15 cases. One patient had two separate nephrostomies performed through the 10th and 11th intercostal spaces. The technique utilizes bi-planar fluoroscopy with a combination of a conventional angiographic machine to provide anterior-posterior fluoroscopy and a C-arm mobile fluoroscopy machine to give a lateral view, displayed on two separate monitors. None of the patients had clinically significant thoracic or abdominal complications. Two patients had minor chest complications. Only one developed changes (plate atelectasis, elevation of the hemi-diaphragm) directly related to the nephrostomy (2%). The second patient had bilateral plate atelectasis and unilateral congestive lung changes after PCNL. These changes were not necessarily related to the procedure but rather to general anesthesia during nephrolithotomy. The authors consider PCN or PCNL through the intercostal approach a safe procedure with a negligible complication rate, provided that it is performed under bi-planar fluoroscopy, which allows determination of the skin entry point just below the level of pleural reflection and provides three-dimensional monitoring of advancement of the puncturing needle toward the target entry point.

  5. Collapse in High-Grade Stenosis during Pulsatile Flow Experiments

    NASA Astrophysics Data System (ADS)

    Kobayashi, Shunichi; Tang, Dalin; Ku, David N.

    It has been hypothesized that blood flow through high grade stenotic arteries may produce conditions in which elastic flow choking may occur. The development of atherosclerotic plaque fracture may be exacerbated by the compressive stresses during collapse. This study explored the effects of pulsatile flow on stenotic flow collapse. Pulsatile flow was produced using a gear pump controlled by a digitized physiologic waveform. Upstream and downstream mean pressures and pulsatile flow rates were measured and digitized. An improved model of arterial stenosis was created using an elastomer with an incremental modulus of elasticity matched to a bovine carotid artery in the relevant range of collapse. Additionally, the model retained a very thick wall in the stenotic region similar to arterial disease. Flow choking was observed for pulsatile pressure drops close to those previously reported for steady flow. The phase difference between flow rate and pressure between upstream and downstream of the stenosis occurred by the compliance of tube and stenosis resistance. For 80% nominal stenosis by diameter and 100+/-30mmHg upstream pressure, collapse occurred for average pulsatile pressure drops of 93mmHg. Pulsatile flow experiments in this model revealed the range of conditions for the flow choking and the paradoxical collapse of the stenosis during systole with expansion during diastole. The stenosis severity was dynamic through the pulse cycle and was significantly greater under flow than the nominal severity. The results indicate that flow choking and stenotic compression may be significant in thick-walled arterial stenoses subjected to pulsatile flow.

  6. Nimotuzumab in combination with radiotherapy in high grade glioma patients

    PubMed Central

    Solomon, Maria Teresa; Miranda, Nederlay; Jorrín, Eugenia; Chon, Ivonne; Marinello, Jorge Juan; Alert, José; Lorenzo-Luaces, Patricia; Crombet, Tania

    2014-01-01

    Nimotuzumab, a humanized antibody targeting epidermal growth factor receptor, has potent anti-proliferative, anti-angiogenic, and pro-apoptotic effects in vitro and in vivo. It also reduces the number of radio-resistant CD133+ glioma stem cells. The antibody has been extensively evaluated in patients with advanced head and neck, glioma, lung, esophageal, pancreatic, and gastric cancer. In this single institution experience, 35 patients with anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) were treated with irradiation and 200 mg doses of nimotuzumab. The first 6 doses were administered weekly, together with radiotherapy, and then treatment continued every 21 days until 1 year. The median number of doses was 12, and the median cumulative dose was thus 2400 mg of nimotuzumab. The most frequent treatment-related toxicities were increase in liver function tests, fever, nausea, anorexia, asthenia, dizziness, and tremors. These adverse reactions were classified as mild and moderate. The median survival time was 12.4 mo or 27.0 mo for patients with GBM or AA patients, respectively, who received curative-intent radiotherapy in combination with the antibody. The survival time of a matched population treated at the same hospital with irradiation alone was decreased (median 8.0 and 12.2 mo for GBM and AA patients, respectively) compared with that of the patients who received nimotuzumab and curative-intent radiotherapy. We have thus confirmed that nimotuzumab is a very well-tolerated drug, lacking cumulative toxicity after maintenance doses. This study, in a poor prognosis population, validates the previous data of survival gain after combining nimotuzumab and radiotherapy, in newly diagnosed high-grade glioma patients. PMID:24521695

  7. Examining Teacher-Assigned Math Grades as Predictors for High-Stakes Testing

    ERIC Educational Resources Information Center

    Denson, Bettina Coley

    2013-01-01

    This study sought to determine whether a relationship existed between teacher-assigned classroom grades and high-stakes test scores. The study examined teacher-assigned math grades in correlation to the student scores on the Florida Comprehensive Assessment test (FCAT) in a selected Florida high school. It also sought to determine the relationship…

  8. Occupational Exploration at Ontario Junior High School: 8th Grade.

    ERIC Educational Resources Information Center

    Bates, Gene; And Others

    The document contains 47 activities for Grade 8. The contents include the following areas: questionnaires; work vocabularies; employment seeking procedures--employment ads, application forms, resumes, job interviews, and resume preparation advice; a 24-page unit presenting occupational information in relation to career choice and job application…

  9. High Performance Slab-on-Grade Foundation Insulation Retrofits

    SciTech Connect

    Goldberg, Louise F.; Mosiman, Garrett E.

    2015-09-01

    ?A more accurate assessment of SOG foundation insulation energy savings than traditionally possible is now feasible. This has been enabled by advances in whole building energy simulation with 3-dimensional foundation modelling integration at each time step together with an experimental measurement of the site energy savings of SOG foundation insulation. Ten SOG insulation strategies were evaluated on a test building to identify an optimum retrofit insulation strategy in a zone 6 climate (Minneapolis, MN). The optimum insulation strategy in terms of energy savings and cost effectiveness consisted of two components: (a) R-20 XPS insulation above grade, and, (b) R-20 insulation at grade (comprising an outer layer of R-10 insulation and an interior layer of R-12 poured polyurethane insulation) tapering to R-10 XPS insulation at half the below-grade wall height (the lower half of the stem wall was uninsulated). The optimum insulation strategy was applied to single and multi-family residential buildings in climate zone 4 - 7. The highest site energy savings of 5% was realized for a single family home in Duluth, MN, and the lowest savings of 1.4 % for a 4-unit townhouse in Richmond, VA. SOG foundation insulation retrofit simple paybacks ranged from 18 to 47 years. There are other benefits of SOG foundation insulation resulting from the increase in the slab surface temperatures. These include increased occupant thermal comfort, and a decrease in slab surface condensation particularly around the slab perimeter.

  10. High School Grade Inflation from 1991 to 2003. Research Report Series 2004-04

    ERIC Educational Resources Information Center

    Woodruff, David J.; Ziomek, Robert L.

    2004-01-01

    This report presents the results of a study investigating inflation in high school grade point average (HSGPA). Inflation was measured by comparing HSGPA to ACT Assessment (ACT) scores over the years 1991 to 2003. The results indicate the presence of grade inflation over the 13 years. That is, HSGPAs increased without a concomitant increase in…

  11. An Investigation of the Relationship between Retention in First Grade and Performance on High Stakes Tests in Third Grade

    ERIC Educational Resources Information Center

    Hughes, Jan N.; Chen, Qi; Thoemmes, Felix; Kwok, Oi-man

    2010-01-01

    The association between grade retention in first grade and passing the third grade state accountability tests, the Texas Assessment of Knowledge and Skills (TAKS) reading and math, was investigated in a sample of 769 students who were recruited into the study when they were in first grade. Of these 769 students, 165 were retained in first grade…

  12. Texas Symposium on Relativistic Astrophysics, 11th, Austin, TX, December 12-17, 1982, Proceedings

    NASA Technical Reports Server (NTRS)

    Evans, D. S. (Editor)

    1984-01-01

    Various papers on relativistic astrophysics are presented. The general subjects addressed include: particle physics and astrophysics, general relativity, large-scale structure, big bang cosmology, new-generation telescopes, pulsars, supernovae, high-energy astrophysics, and active galaxies.

  13. Improved Middle Grades Schools for Improved High School Readiness: Ten Best Practices in the Middle Grades

    ERIC Educational Resources Information Center

    Bottoms, Gene; Timberlake, Allison

    2012-01-01

    In 2009, the Southern Regional Education Board (SREB) Committee to Improve High School Graduation Rates and Achievement, led by then-Governor Sonny Perdue of Georgia, released a report of 10 key recommendations for ensuring more students graduate from high school, and they graduate ready for college and careers. Among these 10 recommendations was…

  14. Selected contributions from the 11th Gas in Marine Sediments International Conference of September 2012, Nice: an introduction

    NASA Astrophysics Data System (ADS)

    Pierre, Catherine; Imbert, Patrice; Mascle, Jean

    2014-06-01

    This Introduction presents an overview of selected contributions from the 11th Gas in Marine Sediments International Conference held on the 4-7 September 2012 in Nice, France, and published in this special issue of Geo-Marine Letters under the guest editorship of Catherine Pierre, Patrice Imbert and Jean Mascle. These cover fluid seepage dynamics at widely varying spatiotemporal scales in a giant buried caldera of the Caspian Sea, mud volcanoes and pockmarks in the Mediterranean and adjoining Gulf of Cadiz, as well as Lake Baikal, pockmarks of shallower waters along the Atlantic French coast and in Baltic Sea lagoons, deepwater pockmarks and cold seeps on the Norwegian margin and the Hikurangi Margin of New Zealand, asphalt seepage sites offshore southern California, and the tectonically controlled southern Chile forearc. We look forward to meeting all again at the 12th Gas in Marine Sediments conference scheduled for 1-6 September 2014 in Taipei, Taiwan.

  15. Taking out one billion tones of carbon: the magic of China's 11thFive-Year Plan

    SciTech Connect

    Lin, Jiang; Zhou, Nan; Levine, Mark D.; Fridley, David

    2007-05-01

    China's 11th Five-Year Plan (FYP) sets an ambitious targetfor energy-efficiency improvement: energy intensity of the country sgross domestic product (GDP) should be reduced by 20 percent from 2005 to2010 (NDRC, 2006). This is the first time that a quantitative and bindingtarget has been set for energy efficiency, and signals a major shift inChina's strategic thinking about its long-term economic and energydevelopment. The 20 percent energy intensity target also translates intoan annual reduction of over one billion tons of CO2 by 2010, making theChinese effort one of most significant carbon mitigation effort in theworld today. While it is still too early to tell whether China willachieve this target, this paper attempts to understand the trend inenergy intensity in China and to explore a variety of options towardmeeting the 20 percent target using a detailed endues energymodel.

  16. Taking out 1 billion tons of CO2: The magic of China's 11th Five-Year Plan?

    SciTech Connect

    Zhou, Nan; Lin, Jiang; Zhou, Nan; Levine, Mark; Fridley, David

    2007-07-01

    China's 11th Five-Year Plan (FYP) sets an ambitious target for energy-efficiency improvement: energy intensity of the country's gross domestic product (GDP) should be reduced by 20% from 2005 to 2010 (NDRC, 2006). This is the first time that a quantitative and binding target has been set for energy efficiency, and signals a major shift in China's strategic thinking about its long-term economic and energy development. The 20% energy intensity target also translates into an annual reduction of over 1.5 billion tons of CO2 by 2010, making the Chinese effort one of most significant carbon mitigation effort in the world today. While it is still too early to tell whether China will achieve this target, this paper attempts to understand the trend in energy intensity in China and to explore a variety of options toward meeting the 20% target using a detailed end-use energy model.

  17. Rapid Economic Growth and Natural Gas Consumption Nexus: Looking forward from Perspective of 11th Malaysian Plan

    NASA Astrophysics Data System (ADS)

    Bekhet, H. A.; Yasmin, T.

    2016-03-01

    The present study investigates the relationship between economic growth and energy consumption by incorporating CO2 emissions, natural gas consumption and population in Malaysia. Annual data and F-bound test and granger causality have applied to test the existence of long run relationship between the series. The results show that variables are cointegrated for long run relationship. The results also indicate that natural gas consumption is an important contributing factor to energy demand and hence economic growth in case of Malaysia. The causality analysis highlights that the feedback hypothesis exists between economic growth and energy consumption. While, conservative hypothesis is validated between natural gas consumption and economic growth which implies that economic growth will push natural gas consumption policies in future. This study opens up new direction for policy makers to formulate a comprehensive natural gas policy to sustain environment for long span of time in case to achieve 11th MP targets.

  18. Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma | Division of Cancer Prevention

    Cancer.gov

    This randomized phase III trial studies armodafinil to see how well it works in reducing cancer-related fatigue in patients with high grade glioma. Armodafinil may help relieve fatigue in patients with high grade glioma. |

  19. Proceedings of the 11th business reporting conference of the NEDO Geothermal Subcommittee

    NASA Astrophysics Data System (ADS)

    Masahiro, Korata

    1991-10-01

    The geothermal energy department at The New Energy and Industrial Technology Overall Development Organization carries out the following activities: a systematic identification of geothermal resource distribution all over Japan; discussions on selection of promising areas together with the criteria for exploration methods by volcanic thermal type; development of integrated analytic methods applied with high-level information processing technologies; site surveys on effectiveness of various physical exploration technologies; and surveys on environmental influence associated with developments. Developments under way on geothermal power generation systems include the following: development of an identification test for simplified medium-to-small size geothermal generation systems at the Kirishima area; and a 10 MW class plant for unused hydrothermal water resources. These developments were made with respect to utilizing geothermal energy possessed by high-temperature rocks, artificial reservoir bed formation by means of the hydraulic fracturing method, evaluation of reservoir bed characteristics by means of well excavation, and circulating heat extraction tests.

  20. View looking northwest toward HIghGrade Ore Bin and Concentrate Bin ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View looking northwest toward HIgh-Grade Ore Bin and Concentrate Bin - Kennecott Copper Corporation, Concentration Mill, On Copper River & Northwestern Railroad, Kennicott, Valdez-Cordova Census Area, AK

  1. How do we manage high-grade T1 bladder cancer? Conservative or aggressive therapy?

    PubMed Central

    Kim, Seon-Kyu; Kim, Wun-Jae

    2016-01-01

    High-grade T1 bladder cancer has a poor prognosis due to a higher incidence of recurrence and progression than other nonmuscle invasive bladder cancer; thus patients with high-grade T1 have to be carefully monitored and managed. If patients are diagnosed with high-grade T1 at initial transurethral resection (TUR), a second TUR is strongly recommended regardless of whether muscle layer is present in the specimen because of the possibility of understating due to incomplete resection. Since high-grade T1 disease shows diverse clinical courses, individual approaches are recommended for treatment. In cases with low risk of progression, cystectomy could represent overtreatment and deteriorate quality of life irreversibly, while, in those with high risk, bacillus Calmette-Guérin (BCG) therapy may worsen survival by delaying definitive therapy. Therefore, a strategy for predicting prognosis based on the risk of progression is needed for managing high-grade T1 disease. Molecular risk classifiers predicting the risk of progression and response to BCG may help identify the optimal management of high-grade T1 disease for each individual. PMID:27326407

  2. ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas

    PubMed Central

    2013-01-01

    Background High-grade (WHO grade III and IV) astrocytomas are aggressive malignant brain tumors affecting humans with a high risk of recurrence in both children and adults. To date, limited information is available on the genetic and molecular alterations important in the onset and progression of pediatric high-grade astrocytomas and, even less, on the prognostic factors that influence long-term outcome in children with recurrence. A-to-I RNA editing is an essential post-transcriptional mechanism that can alter the nucleotide sequence of several RNAs and is mediated by the ADAR enzymes. ADAR2 editing activity is particularly important in mammalian brain and is impaired in both adult and pediatric high-grade astrocytomas. Moreover, we have recently shown that the recovered ADAR2 activity in high-grade astrocytomas inhibits in vivo tumor growth. The aim of the present study is to investigate whether changes may occur in ADAR2-mediated RNA editing profiles of relapsed high-grade astrocytomas compared to their respective specimens collected at diagnosis, in four pediatric patients. Methods Total RNAs extracted from all tumor samples and controls were tested for RNA editing levels (by direct sequencing on cDNA pools) and for ADAR2 mRNA expression (by qRT-PCR). Results A significant loss of ADAR2-editing activity was observed in the newly diagnosed and recurrent astrocytomas in comparison to normal brain. Surprisingly, we found a substantial rescue of ADAR2 editing activity in the relapsed tumor of the only patient showing prolonged survival. Conclusions High-grade astrocytomas display a generalized loss of ADAR2-mediated RNA editing at both diagnosis and relapse. However, a peculiar Case, in complete remission of disease, displayed a total rescue of RNA editing at relapse, intriguingly suggesting ADAR2 activity/expression as a possible marker for long-term survival of patients with high-grade astrocytomas. PMID:23697632

  3. Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma.

    PubMed

    Wu, Wenting; Lamborn, Kathleen R; Buckner, Jan C; Novotny, Paul J; Chang, Susan M; O'Fallon, Judith R; Jaeckle, Kurt A; Prados, Michael D

    2010-02-01

    The purpose of this study is to determine prognostic factors in patients with high-grade recurrent glioma for 3 outcome variables (overall survival, progression-free survival [PFS], and PFS rate 6 months after study registration [PFS6]). Data from 15 North Central Cancer Treatment Group (NCCTG) trials (n = 469, 1980-2004) and 12 North American Brain Tumor Consortium (NABTC) trials (n = 596, 1998-2002) were included. Eighteen prognostic variables were considered including type of treatment center (community/academic) and initial low-grade histology (yes/no). Recursive partitioning analysis (RPA), Cox proportional hazards, and logistic regression models with bootstrap resampling were used to identify prognostic variables. Longer survival was associated with last known grade (Grade) of III, younger age, ECOG performance score (PS) of 0, shorter time from initial diagnosis (DxTime), and no baseline steroid use. Factors associated with longer PFS were Grade III and shorter DxTime. For patients without temozolomide as part of the treatment regimen, the only factor associated with better PFS6 was Grade III, although DxTime was important in RPA and PS was important in logistic regression. Grade was the most important prognostic factor for all three endpoints regardless of the statistical method used. Other important variables for one or more endpoints included age, PS, and DxTime. Neither type of treatment center nor initial low-grade histology was identified as a major predictor for any endpoint. PMID:20150383

  4. Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma

    PubMed Central

    Wu, Wenting; Lamborn, Kathleen R.; Buckner, Jan C.; Novotny, Paul J.; Chang, Susan M.; O'Fallon, Judith R.; Jaeckle, Kurt A.; Prados, Michael D.

    2010-01-01

    The purpose of this study is to determine prognostic factors in patients with high-grade recurrent glioma for 3 outcome variables (overall survival, progression-free survival [PFS], and PFS rate 6 months after study registration [PFS6]). Data from 15 North Central Cancer Treatment Group (NCCTG) trials (n = 469, 1980–2004) and 12 North American Brain Tumor Consortium (NABTC) trials (n = 596, 1998–2002) were included. Eighteen prognostic variables were considered including type of treatment center (community/academic) and initial low-grade histology (yes/no). Recursive partitioning analysis (RPA), Cox proportional hazards, and logistic regression models with bootstrap resampling were used to identify prognostic variables. Longer survival was associated with last known grade (Grade) of III, younger age, ECOG performance score (PS) of 0, shorter time from initial diagnosis (DxTime), and no baseline steroid use. Factors associated with longer PFS were Grade III and shorter DxTime. For patients without temozolomide as part of the treatment regimen, the only factor associated with better PFS6 was Grade III, although DxTime was important in RPA and PS was important in logistic regression. Grade was the most important prognostic factor for all three endpoints regardless of the statistical method used. Other important variables for one or more endpoints included age, PS, and DxTime. Neither type of treatment center nor initial low-grade histology was identified as a major predictor for any endpoint. PMID:20150383

  5. High SEPT9_i1 Protein Expression Is Associated with High-Grade Prostate Cancers

    PubMed Central

    Gilad, Roni; Meir, Karen; Stein, Ilan; German, Larissa; Pikarsky, Eli; Mabjeesh, Nicola J.

    2015-01-01

    Septins are a family of GTP-binding cytoskeleton proteins expressed in many solid tumors. Septin 9 (SEPT9) in particular was found overexpressed in diverse carcinomas. Herein, we studied the expression of SEPT9 isoform 1 protein (SEPT9_i1) in human prostate cancer specimens. We utilized immunohistochemical staining to study the expression of SEPT9_i1 protein. Staining level was analyzed in association with clinical characteristics and the pathological Gleason grade and score. Fifty human prostate cancer specimens (42 primary tumors and 8 metastatic lesions) were stained by SEPT9_i1 antibody and analyzed. SEPT9_i1 protein was expressed in prostate cancer cells but absent in normal epithelial cells. The intensity of staining was correlated proportionally to pretreatment prostate-specific antigen (PSA) blood levels and Gleason score (P < 0.05). SEPT9_i1 was highly expressed in all metastatic lesions. A significant assocation between SEPT9_i1 expression and high Gleason score on multivariate linear regression analysis was found. We conclude that SEPT9_i1 is expressed in high-grade prostate tumors suggesting it has a significant role in prostate tumorigenesis and that it could serve as a molecular marker for prostate tumor progression. PMID:25898316

  6. Embedded Weapons-Grade Tungsten Alloy Shrapnel Rapidly Induces Metastatic High-Grade Rhabdomyosarcomas in F344 Rats

    PubMed Central

    Kalinich, John F.; Emond, Christy A.; Dalton, Thomas K.; Mog, Steven R.; Coleman, Gary D.; Kordell, Jessica E.; Miller, Alexandra C.; McClain, David E.

    2005-01-01

    Continuing concern regarding the potential health and environmental effects of depleted uranium and lead has resulted in many countries adding tungsten alloy (WA)-based munitions to their battlefield arsenals as replacements for these metals. Because the alloys used in many munitions are relatively recent additions to the list of militarily relevant metals, very little is known about the health effects of these metals after internalization as embedded shrapnel. Previous work in this laboratory developed a rodent model system that mimicked shrapnel loads seen in wounded personnel from the 1991 Persian Gulf War. In the present study, we used that system and male F344 rats, implanted intramuscularly with pellets (1 mm × 2 mm cylinders) of weapons-grade WA, to simulate shrapnel wounds. Rats were implanted with 4 (low dose) or 20 pellets (high dose) of WA. Tantalum (20 pellets) and nickel (20 pellets) served as negative and positive controls, respectively. The high-dose WA-implanted rats (n = 46) developed extremely aggressive tumors surrounding the pellets within 4–5 months after implantation. The low-dose WA-implanted rats (n = 46) and nickel-implanted rats (n = 36) also developed tumors surrounding the pellets but at a slower rate. Rats implanted with tantalum (n = 46), an inert control metal, did not develop tumors. Tumor yield was 100% in both the low- and high-dose WA groups. The tumors, characterized as high-grade pleomorphic rhabdomyosarcomas by histopathology and immunohistochemical examination, rapidly metastasized to the lung and necessitated euthanasia of the animal. Significant hematologic changes, indicative of polycythemia, were also observed in the high-dose WA-implanted rats. These changes were apparent as early as 1 month postimplantation in the high-dose WA rats, well before any overt signs of tumor development. These results point out the need for further studies investigating the health effects of tungsten and tungsten-based alloys. PMID:15929896

  7. PREFACE: 11th International Conference on X-ray Microscopy (XRM2012)

    NASA Astrophysics Data System (ADS)

    Xu, Hongjie; Wu, Ziyu; Tai, Renzhong

    2013-10-01

    new work in high-sensitivity phase-contrast and dark-field (small-angle x-ray scattering) images, the latter for his outstanding accomplishments in the field of on-chip zone plate stacking. The location for the XRM2016 conference was voted for by all conference attendees, and Diamond Light Source in the United Kingdom was chosen. A tour of SSRF was attended by nearly 100 participants who got a close look at the seven beamlines in operation before the close of the meeting. We would like to thank all the participants for their active involvement and excellent contributions during the conference and poster session, and the International Program Committee for their guidance, and outstanding support of local organizating committee for a successful XRM2012. Hongjie Xu, Ziyu Wu and Renzhong Tai Proceeding Editors Logos Conference photograph The PDF file also contains a number of photographs taken at the conference and lists of committes and participants.

  8. Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.

    PubMed

    Gielen, Gerrit H; Gessi, Marco; Buttarelli, Francesca R; Baldi, Caterina; Hammes, Jennifer; zur Muehlen, Anja; Doerner, Evelyn; Denkhaus, Dorota; Warmuth-Metz, Monika; Giangaspero, Felice; Lauriola, Libero; von Bueren, André O; Kramm, Christof M; Waha, Andreas; Pietsch, Torsten

    2015-07-01

    Pediatric high-grade gliomas are considered to be different when compared to adult high-grade gliomas in their pathogenesis and biological behavior. Recently, common genetic alterations, including mutations in the H3F3A/ATRX/DAXX pathway, have been described in approximately 30% of the pediatric cases. However, only few cases of infant high-grade gliomas have been analyzed so far. We investigated the molecular features of 35 infants with diffuse high-grade astrocytomas, including 8 anaplastic astrocytomas [World Health Organization (WHO) grade III] and 27 glioblastomas (WHO grade IV) by immunohistochemistry, multiplex ligation probe-dependent amplification (MLPA), pyrosequencing of glioma-associated genes and molecular inversion probe (MIP) assay. MIP and MLPA analyses showed that chromosomal alterations are significantly less frequent in infants compared with high-grade gliomas in older children and adults. We only identified H3F3A K27M in 2 of 34 cases (5.9%), with both tumors located in the posterior fossa. PDGFRA amplifications were absent, and CDKN2A loss could be observed only in two cases. Conversely, 1q gain (22.7%) and 6q loss (18.2%) were identified in a subgroup of tumors. Loss of SNORD located on chromosome 14q32 was observed in 27.3% of the infant tumors, a focal copy number change not previously described in gliomas. Our findings indicate that infant high-grade gliomas appear to represent a distinct genetic entity suggesting a different pathogenesis and biological behavior. PMID:25231549

  9. DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions.

    PubMed

    Sun, Yin; Li, Shu; Shen, Keng; Ye, Shuang; Cao, Dongyan; Yang, Jiaxin

    2015-01-01

    Gene promoter methylation may be used a potential biomarker for detecting solid tumor including cervical cancer. Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and RARB gene in patients with different cervical disease grade. The detection of gene promoter methylation was conducted in two hundred fifty patients' samples including normal cytology (n=48), cervical intraepithelial neoplasia grade 1 (CIN1, n=54), cervical intraepithelial neoplasia grade 2 (CIN2, n=47), cervical intraepithelial neoplasia grade 3 (CIN3, n=56) and cervical squamous cell carcinomas (SCS, n=45). We found there were a significant positive correlation between the promoter methylation status of DAPK1 and cervical disease grade (P=0.022). In addition, the methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade (P < 0.05). All three genes promoters methylated were positive correlated with cervical disease grade (P < 0.001). Receiver operating characteristic (ROC) curves was conducted to evaluate whether the three genes methylation could be used to be a potential marker for diagnosing high grade cervical disease (HSIL and SCC). The cutoff values for the methylation rates of all these genes were 0-5%. Regrettably, only the methylation of MGMT combined with DAPK1 gave 43.4% sensitivity and 68.6% specificity. The current results indicated that MS-HRM-based testing for DNA methylations of MGMT plus DAPK1 genes holds some promise for high grade cervical disease screening. PMID:26823825

  10. DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions

    PubMed Central

    Sun, Yin; Li, Shu; Shen, Keng; Ye, Shuang; Cao, Dongyan; Yang, Jiaxin

    2015-01-01

    Gene promoter methylation may be used a potential biomarker for detecting solid tumor including cervical cancer. Here, we used methylation sensitive-high resolution melting (MS-HRM) analysis to detecting promoter methylation ratios of DAPK1, MGMT and RARB gene in patients with different cervical disease grade. The detection of gene promoter methylation was conducted in two hundred fifty patients’ samples including normal cytology (n=48), cervical intraepithelial neoplasia grade 1 (CIN1, n=54), cervical intraepithelial neoplasia grade 2 (CIN2, n=47), cervical intraepithelial neoplasia grade 3 (CIN3, n=56) and cervical squamous cell carcinomas (SCS, n=45). We found there were a significant positive correlation between the promoter methylation status of DAPK1 and cervical disease grade (P=0.022). In addition, the methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade (P < 0.05). All three genes promoters methylated were positive correlated with cervical disease grade (P < 0.001). Receiver operating characteristic (ROC) curves was conducted to evaluate whether the three genes methylation could be used to be a potential marker for diagnosing high grade cervical disease (HSIL and SCC). The cutoff values for the methylation rates of all these genes were 0-5%. Regrettably, only the methylation of MGMT combined with DAPK1 gave 43.4% sensitivity and 68.6% specificity. The current results indicated that MS-HRM-based testing for DNA methylations of MGMT plus DAPK1 genes holds some promise for high grade cervical disease screening. PMID:26823825

  11. Thallium-201 imaging and estimation of residual high grade astrocytoma

    SciTech Connect

    Stafford-Schuck, K.; Mountz, J.M.; McKeever, P.; Taren, J.; Beierwaltes, W.H.

    1987-09-01

    Thallium-201 brain imaging was performed on five patients as a method to differentiate persistent and/or recurrent viable Grades III and IV astrocytoma tissue from necrosis or post-therapy changes. Planar images of the head and heart were obtained in order to calculate the ratio of tumor counts to cardiac counts. The heart was chosen as the internal reference organ, as thallium uptake dynamics are reproducible under ordinary circumstances. The numerical estimation of thallium uptake in the brain tumor, expressed in terms of the tumor/cardiac index, correlated well with the clinical course in all five patients. By visual inspection, the initial computed tomographic (CT) and thallium images suggested that the tumors were approximately the same size. Follow-up thallium images were discordant with follow-up CT images. Computed tomography, in general, appeared to depict image alterations suggesting more extensive regrowth of tumor than the actual clinical status or thallium brain scans demonstrated. Histologic examination best correlated with thallium images. In one patient's course of imaging they were able to detect tumor recurrence, by means of thallium imaging, 4 months prior to its appearance on CT. When performed serially, the tumor/cardiac index may provide an estimate of residual tumor burden, which can help distinguish tumor recurrence from changes secondary to therapy.

  12. Ninth Grade Physics: A Necessity for High School Science Programs

    ERIC Educational Resources Information Center

    Wilt, John R.

    2005-01-01

    The traditional order in which science courses are taught in U.S. high schools is biology, chemistry, physics. The physics course usually is regarded as very difficult because it requires both high-level mathematical skills and high-level thinking skills; it is taught in the final year of high school to provide time for students to develop the…

  13. Missouri Assessment Program (MAP), Spring 2000: High School Communication Arts, Released Items, Grade 11.

    ERIC Educational Resources Information Center

    Missouri State Dept. of Elementary and Secondary Education, Jefferson City.

    This document deals with testing in communication arts for 11th graders in Missouri public schools. The document contains the following items from Session 1 in the Test Booklet: "Thomas Hart Benton: Champion of the American Scene" (Jan Greenberg and Sandra Jordan) (Items 5, 6, and 7); "Rhythms of the River" (Rebecca Christian) (Item 9), a writing…

  14. Eleventh-Grade High School Students' Accounts of Mathematical Metacognitive Knowledge: Explicitness and Systematicity

    ERIC Educational Resources Information Center

    van Velzen, Joke H.

    2016-01-01

    Theoretically, it has been argued that a conscious understanding of metacognitive knowledge requires that this knowledge is explicit and systematic. The purpose of this descriptive study was to obtain a better understanding of explicitness and systematicity in knowledge of the mathematical problem-solving process. Eighteen 11th-grade…

  15. The Development of Writing Proficiency as a Function of Grade Level: A Linguistic Analysis

    ERIC Educational Resources Information Center

    Crossley, Scott A.; Weston, Jennifer L.; McLain Sullivan, Susan T.; McNamara, Danielle S.

    2011-01-01

    In this study, a corpus of essays stratified by level (9th grade, 11th grade, and college freshman) are analyzed computationally to discriminate differences between the linguistic features produced in essays by adolescents and young adults. The automated tool Coh-Metrix is used to examine to what degree essays written at various grade levels can…

  16. Papillary Immature Metaplasia of the Anal Canal: A Low-grade Lesion That Can Mimic a High-grade Lesion.

    PubMed

    Roberts, Jennifer M; Cornall, Alyssa M; Ekman, Deborah; Law, Carmella; Poynten, I Mary; Jin, Fengyi; Hillman, Richard J; Templeton, David J; Tabrizi, Sepehr N; Garland, Suzanne M; Thurloe, Julia K; Grulich, Andrew E; Farnsworth, Annabelle

    2016-03-01

    In a natural history study of anal human papillomavirus (HPV) infection and HPV-related lesions among homosexual men in Sydney, Australia, we identified 15 examples of papillary immature metaplasia (PIM) in anal biopsy samples. PIM has previously been described in the cervix, but not in the anal canal. PIM is a form of exophytic low-grade squamous intraepithelial lesion (eLSIL) also known as condyloma. In contrast to the maturing keratinocytes and koilocytosis seen in conventional eLSIL, the slender papillary structures of PIM have a surface population of immature squamous cells. In our anal samples PIM was characterized by close proximity to conventional eLSIL, was negative for p16 (p16) expression, and revealed the presence of a single low-risk HPV genotype (either 6 or 11) in laser capture microdissected lesions. The clinical significance of recognizing PIM lies in preventing misdiagnosis as high-grade squamous intraepithelial lesion, (the presumed precursor to anal cancer), due to the morphologic immaturity of the cell population. In routine practice, awareness of anal canal PIM and p16 immunostaining will prevent this. Further study of the natural history of anal canal PIM is needed. PMID:26551619

  17. Large palpable ductal carcinoma in situ is Her-2 positive with high nuclear grade

    PubMed Central

    Monabati, Ahmad; Sokouti, Ali-Reza; Noori, Sadat Noori; Safaei, Akbar; Talei, Abd-Rasul; Omidvari, Shapoor; Azarpira, Negar

    2015-01-01

    Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous group with variable clinical presentation. The exact molecular mechanism is not known why some ductal carcinomas may reach to such a large size but still remains in situ. Although, molecular classification of DCIS lesions and nuclear grading are important for identification of more aggressive lesions but it is not sufficient. Our aim was to examine the expression pattern of immunohistochemical (IHC) markers of ER, PR, HER-2 in palpable DCIS lesions and compare with clinicopathological findings. Our center is referral hospital from South of Iran. Samples were obtained from fifty four patients with a diagnosis of palpable DCIS. Equivocal (2+) case in HER-2 IHC testing was more characterized by chromogenic in situ hybridization. The positive frequency of HER2, ER, and PR was 92%, 48%, and 37% respectively. Palpable DCIS lesions were significantly more HER-2 positive (92%). The DCIS cases were more likely to be of high nuclear grade (grade III) and Her-2 positive cases were more likely to be of high nuclear grade than intermediate grade. All ER negative tumors had high nuclear grade. The Her-2 positivity is suggested as the most important factor responsible for marked in situ proliferation and production of palpable mass. PMID:26097582

  18. An Investigation of the Relationship Between Retention in First Grade and Performance on High Stakes Tests in 3rd Grade

    PubMed Central

    Hughes, Jan N.; Chen, Qi; Thoemmes, Felix; Kwok, Oi-man

    2010-01-01

    The association between grade retention in first grade and passing the third grade state accountability tests, the Texas Assessment of Knowledge and Skills (TAKS) reading and math, was investigated in a sample of 769 students who were recruited into the study when they were in first grade. Of these 769 students, 165 were retained in first grade and 604 were promoted. Using propensity matching, we created five imputed datasets (average N=321) in which promoted and retained students were matched on 67 comprehensive covariates. Using GEE models, we obtained the association between retention and passing the 3rd grade TAKS reading and math tests. The positive association between retention and math scores was significant while the association was marginally significant for reading scores. PMID:20628547

  19. The behavioral impacts of firm-level energy-conservation goals in China's 11th five-year plan.

    PubMed

    Wu, Dan; Xu, Yuan; Leung, Yee; Yung, Chor Wing

    2015-01-01

    Energy efficiency is one of the most effective means of curbing energy consumption and associated pollutant emissions. However, energy-saving opportunities at negative net costs, or an energy-efficiency gap, widely exist and they defy an entirely rational explanation. This paper examines the significant overperformance of energy-intensive firms against their assigned energy-conservation goals in a national program in China's 11th Five-Year plan (2006-2010). Higher energy prices can be only partially responsible for more active energy saving. Behavioral constraints are explained to cause the bounded rationality of firms on energy-efficiency investment. As our theoretical and empirical studies show, energy-conservation goals could overcome such behavioral constraints to accelerate the commercialization of energy-efficiency technologies, reduce uncertainty and hesitancy of relevant investment, facilitate the enrichment of information, and concentrate the attention of firms on energy conservation. We conclude that goal-setting could provide an effective complementary policy instrument in dealing with energy conservation in China and possibly in other parts of the world. PMID:25478688

  20. Unfolding the complexities of ER chaperones in health and disease: report on the 11th international calreticulin workshop.

    PubMed

    Gold, Leslie; Williams, David; Groenendyk, Jody; Michalak, Marek; Eggleton, Paul

    2015-11-01

    The 11th International Calreticulin workshop was held May 15-18, 2015 at New York University School of Medicine-Langone Medical Center, New York. The meeting highlighted many of the new discoveries in the past 2 years involving the important role of molecular chaperones in physiological and pathological processes. Crucial to the understanding of these disease processes was the role of chaperones in maintaining quality control of protein processing in the endoplasmic reticulum, the importance of Ca(2) regulation acting through its action in stress-related diseases, and the trafficking of glycoproteins to the cell surface. Central to maintaining healthy cell physiology is the correct ER-associated protein degradation of specific misfolded proteins. Information on different mechanisms involved in the degradation of misfolded proteins was revealed. This was a landmark meeting for the chaperone field in terms of new insights into their roles in physiology. These insights included the unfolded protein response, innate/adaptive immunity, tissue repair, the functions of calreticulin/chaperones from the cell surface, and extracellular environment. Diseases included neurodegenerative disorders, prion disease, autoimmunity, fibrosis-related disease, the host immune response to cancer, and hematologic diseases associated with calreticulin mutations. The 12th calreticulin workshop is planned for the spring of 2017 in Delphi, Greece. PMID:26395641

  1. Assessment of Building Energy-Saving Policies and Programs in China During the 11th Five Year Plan

    SciTech Connect

    Zhou, Nan; McNeil, Michael; Levine, Mark

    2010-06-07

    China's 11th Five-Year Plan (FYP) sets an ambitious target to reduce the energy intensity per unit of gross domestic product (GDP) by 20% from 2005 to 2010 (NDRC, 2006). In the building sector, the primary energy-saving target allocated during the 11 FYP period is 100 Mtce. Savings are expected to be achieved through the strengthening of enforcement of building energy efficiency codes, existing building retrofits and heat supply system reform, followed by energy management of government office buildings and large scale public buildings, adoption of renewable energy sources. To date, China has reported that it achieved the half of the 20% intensity reduction target by the end of 2008, however, little has been made clear on the status and the impact of the building programs. There has also been lack of description on methodology for calculating the savings and baseline definition, and no total savings that have been officially reported to date. This paper intend to provide both quantitative and qualitative assessment of the key policies and programs in building sector that China has instituted in its quest to fulfill the national goal. Overall, this paper concludes that the largest improvement for building energy efficiency were achieved in new buildings; the program to improve the energy management in government and large scale public buildings are in line with the target; however the progress in the area of existing building retrofit particularly heat supply system reform lags the stated goal by a large amount.

  2. Assessment of Building Energy-Saving Policies and Programs in China During the 11th Five Year Plan

    SciTech Connect

    Zhou, Nan; Mcneil, Michael; Levine, Mark

    2011-03-01

    China's 11th Five-Year Plan (FYP) sets an ambitious target to reduce the energy intensity per unit of gross domestic product (GDP) by 20% from 2005 to 2010 (NDRC, 2006). In the building sector, the primary energy-saving target allocated during the 11 FYP period is 100 Mtce. Savings are expected to be achieved through the strengthening of enforcement of building energy efficiency codes, existing building retrofits and heat supply system reform, followed by energy management of government office buildings and large scale public buildings, adoption of renewable energy sources. To date, China has reported that it achieved the half of the 20% intensity reduction target by the end of 2008, however, little has been made clear on the status and the impact of the building programs. There has also been lack of description on methodology for calculating the savings and baseline definition, and no total savings that have been officially reported to date. This paper intends to provide both quantitative and qualitative assessment of the key policies and programs in building sector that China has instituted in its quest to fulfill the national goal. Overall, this paper concludes that the largest improvement for building energy efficiency were achieved in new buildings; the program to improve the energy management in government and large scale public buildings are in line with the target; however the progress in the area of existing building retrofits, particularly heating supply system reform lags behind the stated goal by a large amount.

  3. Low- to high-grade metamorphic transition in the Southern part of Karnataka Nucleus, India

    NASA Astrophysics Data System (ADS)

    Naqvi, S. M.

    The southern part of Karnataka Nucleus has a strong imprint of 2.6 Ga metamorphism. This has affected the schist belts of Karnataka Nucleus from greenschist to upper amphibolite facies. The higher grades of metamorphism are in the Holenarasipur, Nuggihalli, Krishnarajpet, Hadnur and Melkote schist belts. In the high grade transition zone, around Sargur only keels of schist belts are preserved and occur as highly dismembered, disconnected belts with the top and bottom of the stratigraphic column obliterated due to high grade metamorphism and accompanying migmatization. Absence of high-grade metamorphic minerals in the sediments of the Dharwar schist belts supports the contention that high grade metamorphism post-dated the Dharwar sedimentation and occurred around 2.6 Ga ago. Sargur type metamorphism occurred at upper crustal levels and charnockite type metamorphism occurred in lower crustal levels. The P-T conditions for the mineral assemblage in metapelites of Sargur Group indicate burial depths up to at least 15 km suggesting that they were subducted and later obducted during the development of Early Proterozoic Mobile Belt along the southern border of the Karnataka Nucleus.

  4. Low- to high-grade metamorphic transition in the Southern part of Karnataka Nucleus, India

    NASA Technical Reports Server (NTRS)

    Naqvi, S. M.

    1988-01-01

    The southern part of Karnataka Nucleus has a strong imprint of 2.6 Ga metamorphism. This has affected the schist belts of Karnataka Nucleus from greenschist to upper amphibolite facies. The higher grades of metamorphism are in the Holenarasipur, Nuggihalli, Krishnarajpet, Hadnur and Melkote schist belts. In the high grade transition zone, around Sargur only keels of schist belts are preserved and occur as highly dismembered, disconnected belts with the top and bottom of the stratigraphic column obliterated due to high grade metamorphism and accompanying migmatization. Absence of high-grade metamorphic minerals in the sediments of the Dharwar schist belts supports the contention that high grade metamorphism post-dated the Dharwar sedimentation and occurred around 2.6 Ga ago. Sargur type metamorphism occurred at upper crustal levels and charnockite type metamorphism occurred in lower crustal levels. The P-T conditions for the mineral assemblage in metapelites of Sargur Group indicate burial depths up to at least 15 km suggesting that they were subducted and later obducted during the development of Early Proterozoic Mobile Belt along the southern border of the Karnataka Nucleus.

  5. Research and development of intelligent controller for high-grade sanitary ware

    NASA Astrophysics Data System (ADS)

    Bao, Kongjun; Shen, Qingping

    2013-03-01

    With the social and economic development and people's living standards improve, more and more emphasis on modern society, people improve the quality of family life, the use of intelligent controller applications in high-grade sanitary ware physiotherapy students. Analysis of high-grade sanitary ware physiotherapy common functions pointed out in the production and use of the possible risks, proposed implementation of the system hardware and matching, given the system software implementation process. High-grade sanitary ware physiotherapy intelligent controller not only to achieve elegant and beautiful, simple, physical therapy, water power, deodorant, multi-function, intelligent control, to meet the consumers, the high-end sanitary ware market, strong demand, Accelerate the enterprise product Upgrade and improve the competitiveness of enterprises.

  6. What Your 9th, 10th, and 11th Grader Should Know about Reading, Writing, and Math [and] Science.

    ERIC Educational Resources Information Center

    Colorado State Dept. of Education, Denver.

    Three guides provide sample problems like the ones students would solve on the Colorado Student Assessment Program tests. For each question, the pertinent Colorado state standard is identified. The ninth grade guide contains questions in reading, writing and mathematics; the guide to the 10th grade examination also contains questions related to…

  7. Senior High School Earth Sciences and Marine Sciences.

    ERIC Educational Resources Information Center

    Hackenberg, Mary; And Others

    This guide was developed for earth sciences and marine sciences instruction in the senior high schools of Duval County, Jacksonville, Florida. The subjects covered are: (1) Earth Science for 10th, 11th, and 12th graders; (2) Marine Biology I for 10th, 11th, and 12th graders; (3) Marine Biology II, Advanced, for 11th and 12th graders; (4) Marine…

  8. State Summary Grade 10: Spring 1989 High School Proficiency Test, New Jersey Statewide Testing System.

    ERIC Educational Resources Information Center

    New Jersey State Dept. of Education, Trenton.

    The New Jersey High School Proficiency Test (HSPT) consists of reading, writing, and mathematics sections and must be passed as one of the requirements for a high school diploma. This report includes a series of tables summarizing grade 10 test results statewide for April 11-13, 1989. The results for 6,352 10th graders are given separately for…

  9. Small Classes in the Early Grades, Academic Achievement, and Graduating From High School

    ERIC Educational Resources Information Center

    Finn, Jeremy D.; Gerber, Susan B.; Boyd-Zaharias, Jayne

    2005-01-01

    This investigation addressed 3 questions about the long-term effects of early school experiences: (a) Is participation in small classes in the early grades (K-3) related to high school graduation? (b) Is academic achievement in K-3 related to high school graduation? (c) If class size is related to graduation, is the relationship explained by the…

  10. Molecular Biology in Pediatric High-Grade Glioma: Impact on Prognosis and Treatment

    PubMed Central

    Rizzo, Daniela; Ruggiero, Antonio; Martini, Maurizio; Rizzo, Valentina; Maurizi, Palma; Riccardi, Riccardo

    2015-01-01

    High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biology is starting to impact drug development towards targeted therapies. The identification of agents directed against molecular targets aims at going beyond the traditional therapeutic approach in order to develop a personalized therapy and improve the outcome of pediatric high-grade gliomas. In this paper, we critically review the literature regarding the genetic abnormalities implicated in the pathogenesis of pediatric malignant gliomas and the current development of molecularly targeted therapies. In particular, we analyse the impact of molecular biology on the prognosis and treatment of pediatric high-grade glioma, comparing it to that of adult gliomas. PMID:26448930

  11. The Minimum Grading Controversy: Results of a Quantitative Study of Seven Years of Grading Data from an Urban High School

    ERIC Educational Resources Information Center

    Carey, Theodore; Carifio, James

    2012-01-01

    In an effort to reduce failure and drop-out rates, schools have been implementing minimum grading. One form involves raising catastrophically low student quarter grades to a predetermined minimum--typically a 50. Proponents argue it gives struggling students a reasonable chance to recover from failure. Critics contend the practice induces grade…

  12. Detection of high-grade atypia nuclei in breast cancer imaging

    NASA Astrophysics Data System (ADS)

    Noël, Henri; Roux, Ludovic; Lu, Shijian; Boudier, Thomas

    2015-03-01

    Along with mitotic count, nuclear pleomorphism or nuclear atypia is an important criterion for the grading of breast cancer in histopathology. Though some works have been done in mitosis detection (ICPR 2012,1 MICCAI 2013,2 and ICPR 2014), not much work has been dedicated to automated nuclear atypia grading, especially the most difficult task of detection of grade 3 nuclei. We propose the use of Convolutional Neural Networks for the automated detection of cell nuclei, using images from the three grades of breast cancer for training. The images were obtained from ICPR contests. Additional manual annotation was performed to classify pixels into five classes: stroma, nuclei, lymphocytes, mitosis and fat. At total of 3,000 thumbnail images of 101 × 101 pixels were used for training. By dividing this training set in an 80/20 ratio we could obtain good training results (around 90%). We tested our CNN on images of the three grades which were not in the training set. High grades nuclei were correctly classified. We then thresholded the classification map and performed basic analysis to keep only rounded objects. Our results show that mostly all atypical nuclei were correctly detected.

  13. Manufacturing high reliability weapon grade transformers in small lots

    SciTech Connect

    Archer, W.E.; Sanchez, R.O.

    1998-08-01

    Sandia has used flyback transformers for many years, primarily to charge capacitors for capacitive discharge units. Important characteristics of the transformer design are to meet inductance, turns ratio, and high voltage breakdown requirements as well as not magnetically saturating during each energy transfer cycle. Sandia has taken over production responsibility for magnetic components from a previous GE/LM, General Electric/Lockheed Martin, facility in Florida that produced {approximately} 50 K units per year. Vanguard Electronics is working with Sandia to transfer many of these designs to Vanguard`s small manufacturing facility in Gardena, CA. The challenge is to achieve the required high reliability and meet all the other electrical requirements with such small quantities of parts, {approximately} 100 per year. DOE requirements include high reliability {le} 3 failures per 10,000 components per 20 years while meeting numerous other environmental requirements. The basic design and prove-in required four lots of preproduction parts, extensive environmental testing, and numerous design changes. The manufacturing problems that affected performance of the transformer will be presented. These include encapsulation voids and core alignment. Also, some extended life test data that predicts long term reliability of newly produced transformers versus older designs will be compared.

  14. Post-September 11Th Perspectives on Religion, Spirituality, and Philosophy in the Personal and Professional Lives of Selected REBT Cognoscenti

    ERIC Educational Resources Information Center

    Weinrach, Stephen G.; Dryden, Windy; DiMattia, Dominic J.; Doyle, Kristene A.; MacLaren, Catherine; O'Kelly, Monica; Malkinson, Ruth

    2004-01-01

    The purpose of this article was for selected Rational Emotive Behavior Therapy (REBT) cognoscenti to examine the impact of the events of September 11th, 2001, on their beliefs about religion, spirituality and their personal philosophy--including the role of evil in the universe and the implications of these issues on their use of REBT. The degree…

  15. Relationships among Four Learner Variables and the Performance of Selected Jamaican 11th-Graders on Some Structured Questions on the Mole Concept

    ERIC Educational Resources Information Center

    Ellis-Hall, Nadine; Soyibo, Kola

    2004-01-01

    This study sought to find out if (a) the performance of 113 Jamaican 11th-graders on a mole concept test was satisfactory or not; (b) there were significant differences in their performance linked to their chemical and mathematical abilities, gender and socioeconomic background (SEB); and, (c) there were significant relationships among the four…

  16. Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (11th, Madeira, Portugal, March 14-16, 2015)

    ERIC Educational Resources Information Center

    Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

    2015-01-01

    These proceedings contain the papers and posters of the 11th International Conference on Mobile Learning 2015, which was organised by the International Association for Development of the Information Society, in Madeira, Portugal, March 14-16, 2015. The Mobile Learning 2015 Conference seeks to provide a forum for the presentation and discussion of…

  17. Post-September 11Th Perspectives on Religion, Spirituality, and Philosophy in the Personal and Professional Lives of Selected Rebt Cognoscenti: A Response to My Colleagues.

    ERIC Educational Resources Information Center

    Ellis, Albert

    2004-01-01

    This is a discussion and evaluation of the views of the authors of the article "Post-September 11th Perspectives on Religion, Spirituality, and Philosophy in the Personal and Professional Lives of Selected REBT Cognoscenti." Several of the authors are shown to endorse most of the main principles and practices of Rational Emotive Behavior Therapy…

  18. Proceedings of the International Conference on Cognition and Exploratory Learning in Digital Age (CELDA) (11th, Porto, Portugal, October 25-27, 2014)

    ERIC Educational Resources Information Center

    Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaias, Pedro, Ed.

    2014-01-01

    These proceedings contain the papers of the 11th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2014), October 25-27, 2014, which has been organized by the International Association for Development of the Information Society (IADIS) and endorsed by the Japanese Society for Information and Systems in…

  19. Oncocytoma-Like Renal Tumor With Transformation Toward High-Grade Oncocytic Carcinoma

    PubMed Central

    Sirintrapun, Sahussapont J.; Geisinger, Kim R.; Cimic, Adela; Snow, Anthony; Hagenkord, Jill; Monzon, Federico; Legendre, Benjamin L.; Ghazalpour, Anatole; Bender, Ryan P.; Gatalica, Zoran

    2014-01-01

    Abstract Renal oncocytoma is a benign tumor with characteristic histologic findings. We describe an oncocytoma-like renal tumor with progression to high-grade oncocytic carcinoma and metastasis. A 74-year-old man with no family history of cancer presented with hematuria. Computed tomography showed an 11 cm heterogeneous multilobulated mass in the right kidney lower pole, enlarged aortocaval lymph nodes, and multiple lung nodules. In the nephrectomy specimen, approximately one third of the renal tumor histologically showed regions classic for benign oncocytoma transitioning to regions of high-grade carcinoma without sharp demarcation. With extensive genomic investigation using single nucleotide polymorphism-based array virtual karyotyping, multiregion sequencing, and expression array analysis, we were able to show a common lineage between the benign oncocytoma and high-grade oncocytic carcinoma regions in the tumor. We were also able to show karyotypic differences underlying this progression. The benign oncocytoma showed no chromosomal aberrations, whereas the high-grade oncocytic carcinoma showed loss of the 17p region housing FLCN (folliculin [Birt–Hogg–Dubé protein]), loss of 8p, and gain of 8q. Gene expression patterns supported dysregulation and activation of phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma viral oncogene homolog (Akt), mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK), and mechanistic target of rapamycin (serine/threonine kinase) (mTOR) pathways in the high-grade oncocytic carcinoma regions. This was partly attributable to FLCN underexpression but further accentuated by overexpression of numerous genes on 8q. In the high-grade oncocytic carcinoma region, vascular endothelial growth factor A along with metalloproteinases matrix metallopeptidase 9 and matrix metallopeptidase 12 were overexpressed, facilitating angiogenesis and invasiveness. Genetic molecular testing provided evidence for the

  20. ADVANCES IN IMAGING TECHNOLOGIES IN THE EVALUATION OF HIGH-GRADE BLADDER CANCER

    PubMed Central

    Zlatev, Dimitar V.; Altobelli, Emanuela; Liao, Joseph C.

    2015-01-01

    Bladder cancer is a heterogeneous disease that ranges from low-grade variant with an indolent course, to high-grade subtype with a recurrent, progressive, and potentially lethal outcome. Accurate assessment for individualized treatment depends critically on the diagnostic accuracy of white light cystoscopy. Despite its central role, white light cystoscopy has several well-documented shortcomings including difficult flat lesion detection, imprecise tumor delineation that limits complete resection, differentiation between inflammation and malignancy, and grade and stage determination. As the limitations of white light cystoscopy contribute to the risk of cancer persistence, recurrence, and progression, there is a need for improved visualization of flat, multifocal, high-grade, and muscle-invasive lesions. Optical imaging technologies have emerged as an adjunct to white light cystoscopy with the goal to guide more effective treatment by improving cancer detection and patient stratification on the basis of grade and stage. Photodynamic diagnosis and narrow band imaging are macroscopic imaging modalities similar to white light cystoscopy, but provide additional contrast enhancement of bladder tumors and have been shown to improve detection rates. Confocal laser endomicroscopy and optical coherence tomography are microscopic imaging technologies that enable real-time high resolution, subsurface tissue characterization with spatial resolutions similar to histology. Molecular imaging offers the potential for the combination of optical imaging technologies with cancer-specific molecular agents to improve the specificity of disease detection. PMID:25882557

  1. 5α-reductase Inhibitors and Risk of High-grade or Lethal Prostate Cancer

    PubMed Central

    Preston, Mark A.; Wilson, Kathryn; Markt, Sarah C.; Ge, Rongbin; Morash, Christopher; Stampfer, Meir J.; Loda, Massimo F.; Giovannucci, Edward; Mucci, Lorelei A.; Olumi, Aria F.

    2014-01-01

    Importance 5α-reductase inhibitors (5ARIs) are widely used for benign prostatic hyperplasia despite controversy regarding potential risk of high-grade prostate cancer with use. Furthermore, the effect of 5ARIs on progression and prostate cancer death remains unclear. Objective To determine the association between 5ARI use and development of high-grade or lethal prostate cancer. Design, Setting, and Participants Prospective observational study of 38,058 men followed for prostate cancer diagnosis and outcomes between 1996–2010 in the Health Professionals Follow-up Study. Exposure Use of 5ARIs between 1996–2010. Main Outcome Measures Cox proportional hazards models were used to estimate risk of prostate cancer diagnosis or development of lethal disease with 5ARI use, adjusting for possible confounders including prostate specific antigen testing. Results During 448,803 person-years of follow-up, we ascertained 3681 incident prostate cancer cases. Of these, 289 were lethal (metastatic or fatal), 456 were high-grade (Gleason 8–10), 1238 were Gleason grade 7, and 1600 were low-grade (Gleason 2–6). A total of 2878 (7.6%) men reported use of 5ARIs between 1996 and 2010. After adjusting for confounders, men who reported ever using 5ARIs over the study period had a reduced risk of overall prostate cancer (HR 0.77; 95% CI, 0.65–0.91). 5ARI users had a reduced risk of Gleason 7 (HR 0.67; 95% CI, 0.49–0.91) and low-grade (Gleason 2–6) prostate cancer (HR 0.74; 95% CI, 0.57–0.95). 5ARI use was not associated with risk of high-grade (Gleason 8–10, HR 0.97; 95% CI, 0.64–1.46) or lethal disease (HR 0.99; 95% CI, 0.58–1.69). Increased duration of use was associated with significantly lower risk of overall prostate cancer (HR for 1 year of additional use 0.95; 95% CI, 0.92–0.99), localized (HR 0.95; 95% CI, 0.90–1.00), and low-grade disease (HR 0.92; 95% CI, 0.85–0.99). There was no association for lethal, high-grade, or grade 7 disease. Conclusions and

  2. Field experimental observations of highly graded sediment plumes.

    PubMed

    Jensen, Jacob Hjelmager; Saremi, Sina; Jimenez, Carlos; Hadjioannou, Louis

    2015-06-15

    A field experiment in the waters off the south-eastern coast of Cyprus was carried out to study near-field formation of sediment plumes from dumping. Different loads of sediment were poured into calm and limpid waters one at the time from just above the sea surface. The associated plumes, gravitating towards the seafloor, were filmed simultaneously by four divers situated at different depths in the water column, and facing the plume at different angles. The processes were captured using GoPro-Hero-series cameras. The high-quality underwater footage from near-surface, mid-depth and near-bed positions gives unique insight into the dynamics of the descending plume and near-field dispersion processes, and enables good understanding of flow and sediment transport processes involved from-release-to-deposition of the load in a non-scaled environment. The high resolution images and footages are available through the link provided herein. Observations support the development of a detailed multi-fractional sediment plume model. PMID:25935811

  3. Examining Opportunity-to-Learn and Success in High School Mathematics Performance in California under NCLB

    ERIC Educational Resources Information Center

    Gavrilovic, Daniel Miodrag

    2013-01-01

    The No Child Left Behind Act of 2001 has put many schools under a lot of pressure to meet its high demands. In this quantitative study, the effects that the NCLB act has had on students' opportunity to learn (OTL) and Subject Level Success (SS) from 2004 to 2012 in 9th, 10th, and 11th grade math coursework (Algebra 1, Geometry, Algebra 2, and…

  4. Gravitational waves from a particle in circular orbits around a rotating black hole to the 11th post-Newtonian order

    NASA Astrophysics Data System (ADS)

    Fujita, Ryuichi

    2015-03-01

    We compute the energy flux of the gravitational waves radiated by a particle of mass μ in circular orbits around a rotating black hole of mass M up to the 11th post-Newtonian order (11PN), i.e. v^{22} beyond the leading Newtonian approximation where v is the orbital velocity of the particle [L. Blanchet, Living Rev. Relativity 5, 3 (2002)]. By comparing the PN results for the energy flux with high-precision numerical results in black hole perturbation theory, we find the region of validity in the PN approximation becomes larger with increasing PN order. If one requires the relative error of the energy flux in the PN approximation to be less than 10^{-5}, the energy flux at 11PN (4PN) can be used for v⪉ 0.33 (v ⪉ 0.13). The region of validity can be further extended to v⪉ 0.4 if one applies a resummation method to the energy flux at 11PN. We then compare the orbital phase during a two-year inspiral from the PN results with the high-precision numerical results. We find that, for late (early) inspirals when q≤ 0.3 (q≤ 0.9), where q is the dimensionless spin parameter of the black hole, the difference in the phase is less than 1 (10^{-4}) rad and hence these inspirals may be detected in the data analysis for space detectors such as eLISA/New Gravitational wave Observatory by the PN templates. We also compute the energy flux radiated into the event horizon for a particle in circular orbits around a non-rotating black hole at 22.5PN, i.e. v^{45} beyond the leading Newtonian approximation, which is comparable to the PN order derived in our previous work for the energy flux to infinity at 22PN.

  5. Sex, grade, and course differences in attitudes that are related to cognitive performance in secondary science

    NASA Astrophysics Data System (ADS)

    Levin, James; Seymour Fowler, H.

    The purpose of this study was to collect and analyze data on sexual differences in secondary school students' attitudes towards science. Attitudinal differences were also analyzed for the independent variables of science programs and grade levels. Data were collected from 988 students using a modified version of the Fennema-Sherman Mathematics Attitude Scales to represent attitudes toward science. Reliabilities of the modified science subscales were all high ( > 0.83). Multivariate analysis of variance (MANOVA) was used to analyze the data for the main and interaction effects of the independent variables of sex (male, female), grade level (10th, 11th, 12th), and science program (advanced placement, academic, general, terminal). Significant differences (p < 0.05) were indicated for all main effects (sex, grade, science program). Interaction effects were not found. Mean separations for the various levels of sex, grade, and science program were performed for all attitudinal subscales. Females evidenced a significantly more positive attitude (p 0.01) than males on three subscales: Attitude Toward Success in Science Scale, Science as a Male Domain Scale, and Teacher Scale. Although not significant, males evidenced more positive attitudes on all the remaining five subscales. Eleventh graders evidenced significantly more positive attitudes than tenth graders on all but the Effectance Motivation Scale. Students in 11th grade had more positive attitudes than 12th-grade students on all scales but Science as a Male Domain Scale; however, these differences were not significant. Tenth graders differed significantly from 12th graders on three subscales; Science Usefulness Scale, Confidence in Learning Science Scale, and Teacher Scale. Positive attitudes decreased from advanced placement to terminal programs. Academic students did not differ significantly from general students except on the Father Scale; however, they were significantly different (more positive) from the terminal

  6. Energy and Economics for the Senior High Grades. Unit III. Lessons and Activities for the Senior High Grades.

    ERIC Educational Resources Information Center

    Backler, Alan

    Twelve energy lessons developed for use by senior high school students are presented. These lessons are designed to help students become more aware of the energy choices that they must make in the present and for the future and to understand that the costs of maintaining a specific standard of living and thriving national economy can be controlled…

  7. Industry-grade high average power femtosecond light source

    NASA Astrophysics Data System (ADS)

    Heckl, O. H.; Weiler, S.; Fleischhaker, R.; Gebs, R.; Budnicki, A.; Wolf, M.; Kleinbauer, J.; Russ, S.; Kumkar, M.; Sutter, D. H.

    2014-03-01

    Ultrashort pulses are capable of processing practically any material with negligible heat affected zone. Typical pulse durations for industrial applications are situated in the low picosecond-regime. Pulse durations of 5 ps or below are a well established compromise between the electron-phonon interaction time of most materials and the need for pulses long enough to suppress detrimental effects such as nonlinear interaction with the ablated plasma plume. However, sub-picosecond pulses can further increase the ablation efficiency for certain materials, depending on the available average power, pulse energy and peak fluence. Based on the well established TruMicro 5000 platform (first release in 2007, third generation in 2011) an Yb:YAG disk amplifier in combination with a broadband seed laser was used to scale the output power for industrial femtosecond-light sources: We report on a subpicosecond amplifier that delivers a maximum of 160 W of average output power at pulse durations of 750 fs. Optimizing the system for maximum peak power allowed for pulse energies of 850 μJ at pulse durations of 650 fs. Based on this study and the approved design of the TruMicro 5000 product-series, industrygrade, high average power femtosecond-light sources are now available for 24/7 operation. Since their release in May 2013 we were able to increase the average output power of the TruMicro 5000 FemtoEdition from 40 W to 80 W while maintaining pulse durations around 800 fs. First studies on metals reveal a drastic increase of processing speed for some micro processing applications.

  8. Treatment of High-Grade Anal Dysplasia in High Risk Patients: Outcome at an Urban Community Health Center

    PubMed Central

    Assoumou, Sabrina Annick; Panther, Lori Ann; Feng, Yang; Gelman, Rebecca Sue; Fugelso, Dana Kailani; Mayer, Kenneth Hugh

    2013-01-01

    SUMMARY Human immunodeficiency (HIV)-infected patients and men who have sex with men (MSM) have a higher rate of high-grade anal intraepithelial neoplasia (HGAIN), a likely precursor to anal cancer. This retrospective study describes the outcome of treating MSM with incident biopsy-proven HGAIN in an urban community health setting with access to outpatient ablation or operative treatment. The main outcome was freedom from HGAIN at follow-up. 153 met inclusion criteria; 86 (56%) were HIV-infected. Eighty (52%) received outpatient ablation, 49(61%) had a follow-up within 9 months. Among those, 26 (53%) were free of high-grade disease, 19 (39%) had high-grade disease; and 4 (8%) had unknown grading. In a logistic regression model, a lower extent of anal disease (1 quadrant vs. 2,3, or 4 quadrants) was significantly associated with a lower probability of high-grade disease (p-value 0.04.) HGAIN could be managed in a community health setting; however, systems are needed to ensure follow-up care. PMID:23535356

  9. Clonal evolution of B cells in transformation from low- to high-grade lymphoma

    PubMed Central

    Matolcsy, András; Schattner, Elaine J.; Knowles, Daniel M.; Casali, Paolo

    2015-01-01

    An outcome of low-grade B cell non-Hodgkins's lymphomas is the transformation to high-grade diffuse large B cell lymphomas (DLBL). To investigate the mechanisms of clonal evolution in the transformation to DLBL, we performed longitudinal molecular analyses of immunoglobulin (Ig), VHDJH gene sequences expressed in cases of chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and follicular lymphoma (FL) that transformed to DLBL. Among the neoplastic CLL and SLL cells and their respective high-grade transformants, there was no evidence for a clonotypic shift or acquired mutations in the expressed Ig VHDJH gene segments, as further confirmed by a specific and sensitive PCR-single strand polymorphism analysis. In contrast, among the FL cells there was a high degree of intraclonal diversification with highly divergent VHDJH gene sequences. Despite this intraclonal heterogeneity, the related DLBL expressed a collinear but unique VHDJH gene sequence. The intraclonal genealogical tree for the FL case demonstrated that the DLBL emerged in association with unique VHDJH gene mutational events. Among the intraclonal FL and related DLBL transformants, the nature and distribution of the Ig VHDJH gene mutations were consistent with antigenic selection. Thus, clonal evolution in the transformation from low- to high-grade B cell lymphoma may involve distinct pathways which vary according to the cellular origin and the type of the progenitor B cell tumor. PMID:10229093

  10. Supporting Young Adolescents' Middle-to-High-School Transition by Creating a Ninth Grade Community of Care: Implications for Middle Grades Educators

    ERIC Educational Resources Information Center

    Ellerbrock, Cheryl R.; Kiefer, Sarah M.

    2014-01-01

    The middle-to-high-school transition and the first year of high school are critical periods in students' lives. According to the Southern Regional Education Board (SREB), "The passage of students from the middle grades to high school is the most difficult transition point in education" (2002, p. 24). Although there are many…

  11. Proceedings of the 11th International Conference on Magnetic Fluids (ICMF 11) (Košice, Slovakia, 23-27 July 2007).

    PubMed

    Kopčanský, Peter; Timko, Milan; Kováč, Josef; Václavíková, Miroslava; Odenbach, Stefan

    2008-05-21

    The 11th International Conference on Magnetic Fluids (ICMF 11) was held in Košice, Slovakia between 23-27 July 2007. Attendance at the conference was high and its motivation was in line with the ten previous ICMF conferences organized in Udine, Orlando, Bangor, Sendai-Tokyo, Riga, Paris, Bhavnagar, Timisoara, Bremen and Guarujá. The conference in Slovakia reflected the scientific community's enthusiasm and worldwide support, with 256 participants, from 30 countries attending.The main objective of ICMF 11 was to promote progress and knowledge in the field of magnetic fluids regarding their chemistry, physical and magnetic properties, heat and mass transfer, surface phenomena, as well as their technological and biomedical applications. As research on magnetic fluids is essentially interdisciplinary, experts from related areas were invited to present their contributions with a view to increasing knowledge in the field and highlighting new trends. Submitted communications were refereed by members of the Scientific Organizing Committee and abstracts were assembled in a book of abstracts. Participants presented 180 posters in two poster sessions and 56 oral presentations. All presentations contributed to a greater understanding of the area, and helped to bridge the gap between physics, chemistry, technology, biology and medical sciences. Contributions to this conference are presented in 115 scientific papers, with some published in Journal of Physics: Condensed Matter and the rest in Magnetohydrodynamics. The organization of the conference was made possible by generous support from the Institute of Experimental Physics and Institute of Geotechnics of the Slovak Academy of Sciences, the University of Pavol Jozef Šafárik and the Slovak Physical Society. Financial support from Ferrotec, Cryosoft Ltd, Mikrochem, Liquids Research Ltd, Askony and US Steel Košice, is also gratefully acknowledged. PMID:21694229

  12. Preface: Proceedings of the 11th International Conference on Magnetic Fluids (ICMF 11) (Košice, Slovakia, 23 27 July 2007)

    NASA Astrophysics Data System (ADS)

    Kopčanský, Peter; Timko, Milan; Kováč, Josef; Václavíková, Miroslava; Odenbach, Stefan

    2008-05-01

    The 11th International Conference on Magnetic Fluids (ICMF 11) was held in Košice, Slovakia between 23-27 July 2007. Attendance at the conference was high and its motivation was in line with the ten previous ICMF conferences organized in Udine, Orlando, Bangor, Sendai-Tokyo, Riga, Paris, Bhavnagar, Timisoara, Bremen and Guarujá. The conference in Slovakia reflected the scientific community's enthusiasm and worldwide support, with 256 participants, from 30 countries attending.The main objective of ICMF 11 was to promote progress and knowledge in the field of magnetic fluids regarding their chemistry, physical and magnetic properties, heat and mass transfer, surface phenomena, as well as their technological and biomedical applications. As research on magnetic fluids is essentially interdisciplinary, experts from related areas were invited to present their contributions with a view to increasing knowledge in the field and highlighting new trends. Submitted communications were refereed by members of the Scientific Organizing Committee and abstracts were assembled in a book of abstracts. Participants presented 180 posters in two poster sessions and 56 oral presentations. All presentations contributed to a greater understanding of the area, and helped to bridge the gap between physics, chemistry, technology, biology and medical sciences. Contributions to this conference are presented in 115 scientific papers, with some published in Journal of Physics: Condensed Matter and the rest in Magnetohydrodynamics. The organization of the conference was made possible by generous support from the Institute of Experimental Physics and Institute of Geotechnics of the Slovak Academy of Sciences, the University of Pavol Jozef Šafárik and the Slovak Physical Society. Financial support from Ferrotec, Cryosoft Ltd, Mikrochem, Liquids Research Ltd, Askony and US Steel Košice, is also gratefully acknowledged.

  13. Low-Grade Dysplasia in Ulcerative Colitis: Risk Factors for Developing High-Grade Dysplasia or Colorectal Cancer

    PubMed Central

    Choi, Chang-ho Ryan; Ignjatovic-Wilson, Ana; Askari, Alan; Lee, Gui Han; Warusavitarne, Janindra; Moorghen, Morgan; Thomas-Gibson, Siwan; Saunders, Brian P; Rutter, Matthew D; Graham, Trevor A; Hart, Ailsa L

    2015-01-01

    OBJECTIVES: The aim of this study was to identify risk factors associated with development of high-grade dysplasia (HGD) or colorectal cancer (CRC) in ulcerative colitis (UC) patients diagnosed with low-grade dysplasia (LGD). METHODS: Patients with histologically confirmed extensive UC, who were diagnosed with LGD between 1993 and 2012 at St Mark's Hospital, were identified and followed up to 1 July 2013. Demographic, endoscopic, and histological data were collected and correlated with the development of HGD or CRC. RESULTS: A total of 172 patients were followed for a median of 48 months from the date of initial LGD diagnosis (interquartile range (IQR), 15–87 months). Overall, 33 patients developed HGD or CRC (19.1% of study population; 20 CRCs) during study period. Multivariate Cox proportional hazard analysis revealed that macroscopically non-polypoid (hazard ratio (HR), 8.6; 95% confidence interval (CI), 3.0–24.8; P<0.001) or invisible (HR, 4.1; 95% CI, 1.3–13.4; P=0.02) dysplasia, dysplastic lesions ≥1 cm in size (HR, 3.8; 95% CI, 1.5–13.4; P=0.01), and a previous history of “indefinite for dysplasia” (HR, 2.8; 95% CI, 1.2–6.5; P=0.01) were significant contributory factors for HGD or CRC development. Multifocal dysplasia (HR, 3.9; 95% CI, 1.9–7.8; P<0.001), metachronous dysplasia (HR, 3.5; 95% CI, 1.6–7.5; P=0.001), or a colonic stricture (HR, 7.4; 95% CI, 2.5–22.1; P<0.001) showed only univariate correlation to development of HGD or CRC. CONCLUSIONS: Lesions that are non-polypoid or endoscopically invisible, large (≥1 cm), or preceded by indefinite dysplasia are independent risk factors for developing HGD or CRC in UC patients diagnosed with LGD. PMID:26416190

  14. High frequency of mismatch repair deficiency among pediatric high grade gliomas in Jordan.

    PubMed

    Amayiri, Nisreen; Tabori, Uri; Campbell, Brittany; Bakry, Doua; Aronson, Melyssa; Durno, Carol; Rakopoulos, Patricia; Malkin, David; Qaddoumi, Ibrahim; Musharbash, Awni; Swaidan, Maisa; Bouffet, Eric; Hawkins, Cynthia; Al-Hussaini, Maysa

    2016-01-15

    Biallelic mismatch repair deficiency (bMMRD) is a cancer predisposition syndrome affecting primarily individuals from consanguinous families resulting in multiple childhood cancers including high grade gliomas (HGG). This is the first study to assess the prevalence of bMMRD among patients with HGG in countries where consanguinity is high. We collected molecular and clinical information on all children diagnosed with HGG and supratentorial primitive neuroectodermal tumors (sPNET) between 2003 and 2013 at King Hussein Cancer Center, Jordan. Comparison was made to a similar cohort from Toronto. Clinical data regarding presence of café au lait macules(CAL), family history of cancer, consanguinity, pathology and treatment were collected. Tumors were centrally reviewed and tested for MMRD by immunohistochemistry of the corresponding proteins. Forty-two patients fulfilled the inclusion criteria, including 36 with HGG. MMRD was observed in 39% of HGG of whom 79% also lost MMR staining in the corresponding normal cells suggestive of bMMRD. P53 dysfunction was highly enriched in MMR deficient tumors (p = 0.0003).The frequency of MMRD was significantly lower in Toronto cohort (23%, p = 0.03). Both evidence of CAL and consanguinity correlated with bMMRD (p = 0.005 and 0.05,respectively) but family history of cancer didn't. HGG with all three bMMRD risk factors had evidence of MMRD and all children affected by multiple bMMRD related cancers had identical gene loss by immunohistochemical staining. In Jordan, the frequency of clinical and immunohistochemical alterations suggestive of bMMRD in pediatric HGG is high. Genetic testing will enable appropriate counseling and cancer screening to improve survival of these patients. PMID:26293621

  15. Delaware Student Testing Program: State Summary Report: Science & Social Studies, Spring 2002 Administration, Grades 8 and 11.

    ERIC Educational Resources Information Center

    Delaware State Dept. of Education, Dover. Assessment and Accountability Branch.

    The results from the third administration of the 8th and 11th grade science and social studies portions of the Delaware Student Testing Program (DSTP) represent an important step in Delawares efforts to educate all students to a higher level. Science and social studies data for grades 8 and 11 are summarized here, and the results for grades 4 and…

  16. Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer.

    PubMed

    Moran-Jones, Kim; Gloss, Brian S; Murali, Rajmohan; Chang, David K; Colvin, Emily K; Jones, Marc D; Yuen, Samuel; Howell, Viive M; Brown, Laura M; Wong, Carol W; Spong, Suzanne M; Scarlett, Christopher J; Hacker, Neville F; Ghosh, Sue; Mok, Samuel C; Birrer, Michael J; Samimi, Goli

    2015-12-29

    Ovarian cancer is the most common cause of death among women with gynecologic cancer. We examined molecular profiles of fibroblasts from normal ovary and high-grade serous ovarian tumors to identify novel therapeutic targets involved in tumor progression. We identified 2,300 genes that are significantly differentially expressed in tumor-associated fibroblasts. Fibroblast expression of one of these genes, connective tissue growth factor (CTGF), was confirmed by immunohistochemistry. CTGF protein expression in ovarian tumor fibroblasts significantly correlated with gene expression levels. CTGF is a secreted component of the tumor microenvironment and is being pursued as a therapeutic target in pancreatic cancer. We examined its effect in in vitro and ex vivo ovarian cancer models, and examined associations between CTGF expression and clinico-pathologic characteristics in patients. CTGF promotes migration and peritoneal adhesion of ovarian cancer cells. These effects are abrogated by FG-3019, a human monoclonal antibody against CTGF, currently under clinical investigation as a therapeutic agent. Immunohistochemical analyses of high-grade serous ovarian tumors reveal that the highest level of tumor stromal CTGF expression was correlated with the poorest prognosis. Our findings identify CTGF as a promoter of peritoneal adhesion, likely to mediate metastasis, and a potential therapeutic target in high-grade serous ovarian cancer. These results warrant further studies into the therapeutic efficacy of FG-3019 in high-grade serous ovarian cancer. PMID:26575166

  17. Life in the Fast Lane: Effects of Early Grade Acceleration on High School and College Outcomes

    ERIC Educational Resources Information Center

    McClarty, Katie Larsen

    2015-01-01

    Research has repeatedly demonstrated the positive effects of acceleration for gifted and talented students. This study expands the literature by not only evaluating the impact of early grade skipping on high school and college outcomes but also examining the role of postacceleration opportunities on subsequent performance. Using a representative…

  18. High School Grade Inflation from 2004 to 2011. ACT Research Report Series, 2013 (3)

    ERIC Educational Resources Information Center

    Zhang, Qian; Sanchez, Edgar I.

    2013-01-01

    This study explores inflation in high school grade point average (HSGPA), defined as trend over time in the conditional average of HSGPA, given ACT® Composite score. The time period considered is 2004 to 2011. Using hierarchical linear modeling, the study updates a previous analysis of Woodruff and Ziomek (2004). The study also investigates…

  19. Accelerated Mathematics and High-Ability Students' Math Achievement in Grades Three and Four

    ERIC Educational Resources Information Center

    Stanley, Ashley M.

    2011-01-01

    The purpose of this study was to explore the relationship between the use of a computer-managed integrated learning system entitled Accelerated Math (AM) as a supplement to traditional mathematics instruction on achievement as measured by TerraNova achievement tests of third and fourth grade high-ability students. Gender, socioeconomic status, and…

  20. The Relationships between Coaching and Instruction in the Primary Grades: Evidence from High-Poverty Schools

    ERIC Educational Resources Information Center

    Walpole, Sharon; McKenna, Michael C.; Uribe-Zarain, Ximena; Lamitina, David

    2010-01-01

    In this study of 116 high-poverty schools, we explored teaching and coaching in grades K-3. We developed and validated observation protocols for both coaching and teaching. Exploratory and confirmatory factor analyses were computed to identify and confirm factors that explained the protocol data. Three coaching factors were identified in both…

  1. Motivating Every Student in Literacy (Including the Highly Unmotivated!), Grades 3-6

    ERIC Educational Resources Information Center

    Athans, Sandra K.; Devine, Denise Ashe

    2010-01-01

    "Motivating Every Student in Literacy (Including the Highly Unmotivated!), Grades 3-6" provides an effective model for improving reading levels and increasing motivation. Under the guidance of Athans and Devine, classroom leaders develop their own Motivation Improvement Action Plans, where small-group instruction, end-of-unit assessments, and…

  2. Thematic Approach to Literature, Language, and Composition, Grades 7, 8, 9: Junior High School Course Guide.

    ERIC Educational Resources Information Center

    Cleveland Heights - University Heights City School District, Cleveland Heights, OH.

    This presentation of a thematic approach to the teaching of literature, language, and composition in grades 7-9 begins with an overview and rationale for the approach, a general statement of course content, and a discussion of those resources which influenced the formation of the program. The thematic programs in literature for high ability and…

  3. The Impact of High-Speed Internet Connectivity at Home on Eighth-Grade Student Achievement

    ERIC Educational Resources Information Center

    Kingston, Kent J.

    2013-01-01

    In the fall of 2008 Westside Community Schools - District 66, in Omaha, Nebraska implemented a one-to-one notebook computer take home model for all eighth-grade students. The purpose of this study was to determine the effect of a required yearlong one-to-one notebook computer program supported by high-speed Internet connectivity at school on (a)…

  4. Group Art Therapy with Eighth-Grade Students Transitioning to High School

    ERIC Educational Resources Information Center

    Spier, Erin

    2010-01-01

    This study examined the effectiveness of a group art therapy intervention within a school setting to increase coping skills and decrease disruptive behaviors in a group of 6 eighth-grade students at risk for making a poor transition to high school. The mixed-method AB single-case experiment measured each individual's changes in behavior and coping…

  5. Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

    PubMed Central

    Moran-Jones, Kim; Gloss, Brian S.; Murali, Rajmohan; Chang, David K.; Colvin, Emily K.; Jones, Marc D.; Yuen, Samuel; Howell, Viive M.; Brown, Laura M.; Wong, Carol W.; Spong, Suzanne M.; Scarlett, Christopher J.; Hacker, Neville F.; Ghosh, Sue; Mok, Samuel C.; Birrer, Michael J.; Samimi, Goli

    2015-01-01

    Ovarian cancer is the most common cause of death among women with gynecologic cancer. We examined molecular profiles of fibroblasts from normal ovary and high-grade serous ovarian tumors to identify novel therapeutic targets involved in tumor progression. We identified 2,300 genes that are significantly differentially expressed in tumor-associated fibroblasts. Fibroblast expression of one of these genes, connective tissue growth factor (CTGF), was confirmed by immunohistochemistry. CTGF protein expression in ovarian tumor fibroblasts significantly correlated with gene expression levels. CTGF is a secreted component of the tumor microenvironment and is being pursued as a therapeutic target in pancreatic cancer. We examined its effect in in vitro and ex vivo ovarian cancer models, and examined associations between CTGF expression and clinico-pathologic characteristics in patients. CTGF promotes migration and peritoneal adhesion of ovarian cancer cells. These effects are abrogated by FG-3019, a human monoclonal antibody against CTGF, currently under clinical investigation as a therapeutic agent. Immunohistochemical analyses of high-grade serous ovarian tumors reveal that the highest level of tumor stromal CTGF expression was correlated with the poorest prognosis. Our findings identify CTGF as a promoter of peritoneal adhesion, likely to mediate metastasis, and a potential therapeutic target in high-grade serous ovarian cancer. These results warrant further studies into the therapeutic efficacy of FG-3019 in high-grade serous ovarian cancer. PMID:26575166

  6. Deep brain stimulation and development of a high-grade glioma: incidental or causal association?

    PubMed

    Mindermann, Thomas; Mendelowitsch, Aminadav

    2016-05-01

    We report the case of a patient in whom 8.8 years following the implantation of a bilateral deep brain stimulation (DBS) into the Vim, a high-grade glioma was diagnosed in close proximity to the two electrode leads. A possible relationship between the permanent DBS and the development of the brain tumour is discussed. PMID:26993141

  7. Career Education: Some Essential Learner Outcomes. Senior High Grades 10, 11, 12.

    ERIC Educational Resources Information Center

    Tennyson, W. Wesley; And Others

    This guide, one of a series for various grade levels, contains Some Essential Learner Ouctomes (SELOs) for career education in high schools in Minnesota. (The SELOs are selected samples of knowledge statements considered as essential learning outcomes for students in each of the subject areas taught in schools.) These SELOs for the senior high…

  8. Isolated third nerve palsy: A rare presentation of high grade glioma.

    PubMed

    Singh, Deepak Kumar; Singh, Neha; Singh, Ragini

    2016-01-01

    High grade gliomas account for almost one-third of primary central nervous system neoplasm, mainly in adults with a mean age of 41 years. They usually present with symptoms of raised intracranial pressure such as headache, vomiting, and seizures. We report a case of 55-year-old male presenting with right side complete third nerve palsy. Magnetic resonance imaging revealed an intraaxial tumor of the right medial temporal lobe. The tumor was removed grossly, and the histological diagnosis was anaplastic astrocytoma (WHO grade 3). We discuss clinical presentation of this case along with pertinent literature. PMID:27057228

  9. Isolated third nerve palsy: A rare presentation of high grade glioma

    PubMed Central

    Singh, Deepak Kumar; Singh, Neha; Singh, Ragini

    2016-01-01

    High grade gliomas account for almost one-third of primary central nervous system neoplasm, mainly in adults with a mean age of 41 years. They usually present with symptoms of raised intracranial pressure such as headache, vomiting, and seizures. We report a case of 55-year-old male presenting with right side complete third nerve palsy. Magnetic resonance imaging revealed an intraaxial tumor of the right medial temporal lobe. The tumor was removed grossly, and the histological diagnosis was anaplastic astrocytoma (WHO grade 3). We discuss clinical presentation of this case along with pertinent literature. PMID:27057228

  10. Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China.

    PubMed

    Xiao, Meizhu; Xu, Qiuxiang; Li, Hongyan; Gao, Huiqiao; Bie, Yachun; Zhang, Zhenyu

    2016-01-01

    The aim of the study is to investigate the prevalence of high-risk human papillomavirus (hr-HPV) genotypes among Han women with high-grade cervical lesions in Beijing, China.Cervical cell specimens from patients with histopathologically confirmed cervical lesions at 7 hospitals in Beijing were examined with a validated HPV kit for 13 hr-HPV genotypes during the study period. The patients were divided into a low-grade cervical lesions group (cervical intraepithelial neoplasia grade 1, CIN1) and a high-grade cervical lesions group (CIN2+, including cervical intraepithelial neoplasia grade 2, CIN2; cervical intraepithelial neoplasia grade 3, CIN3; squamous cervical cancer, SCC; and adenocarcinoma of the cervix, ACC) based on the histopathology results.A total of 2817 eligible patients were enrolled, including 610 cases identified as CIN1 and 2207 as CIN2+. The hr-HPV positive rates in the CIN1 and CIN2+ groups were 78.2% (477/610) and 93.3% (2060/2207), respectively. The most frequently detected genotypes were HPV16, 58, 52 and18 in the CIN1 group and HPV16, 58, 33, and 52 in the CIN2+ group, in descending order of prevalence. In addition, the prevalence of HPV18 among the patients with ACC was 28.6% (14/49), significantly >7.2% (54/752) prevalence among the SCC patients (P < 0.001). Additionally, significantly more women in the CIN2+ group had multiple infections compared with those in the CIN1 group (38.1% and 24.9%, respectively; P < 0.001). However, as the cervical lesion grade increased, the prevalence of multiple hr-HPV infections gradually deceased to 44.2% in the CIN2 patients, 36.7% in the CIN3 patients, and 35.3% in the cervical cancer (CC) patients, which included SCC and ACC patients. In cases of multiple hr-HPV infections in the CIN2+ group, double infections accounted for ∼76.6%, and HPV16+58, HPV16+52, and HPV16+18 were the most common combinations, in descending order. The most frequent combination for triple infections was HPV16+58+31, with

  11. Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation

    PubMed Central

    Hayes, Josie; Thygesen, Helene; Droop, Alastair; Hughes, Thomas A.; Westhead, David; Lawler, Sean E.; Wurdak, Heiko; Short, Susan C.

    2015-01-01

    MicroRNA expression can be exploited to define tumor prognosis and stratification for precision medicine. It remains unclear whether prognostic microRNA signatures are exclusively tumor grade and/or molecular subtype-specific, or whether common signatures of aggressive clinical behavior can be identified. Here, we defined microRNAs that are associated with good and poor prognosis in grade III and IV gliomas using data from The Cancer Genome Atlas. Pathway analysis of microRNA targets that are differentially expressed in good and poor prognosis glioma identified a link to oligodendrocyte development. Notably, a microRNA expression profile that is characteristic of a specific oligodendrocyte precursor cell type (OP1) correlates with microRNA expression from 597 of these tumors and is consistently associated with poor patient outcome in grade III and IV gliomas. Our study reveals grade-independent and subtype-independent prognostic molecular signatures in high-grade glioma and provides a framework for investigating the mechanisms of brain tumor aggressiveness. PMID:25897422

  12. GRADE in Systematic Reviews of Acupuncture for Stroke Rehabilitation: Recommendations based on High-Quality Evidence

    PubMed Central

    Xin, Zhang; Xue-Ting, Liu; De-Ying, Kang

    2015-01-01

    Systematic reviews (SRs) of randomized controlled trials (RCTs) have demonstrated acupuncture’s effectiveness in stroke rehabilitation. The current study reviews the quality of evidence in SRs of acupuncture in stroke rehabilitation, and rates the strength of recommendation for its use based on this evidence using the GRADE (grading of recommendations, assessment, development and evaluations) approach. A comprehensive literature search was performed using multiple databases (e.g., Medline, Embase) with advanced search strategies. Two authors independently selected articles, collected data, and assessed the methodological quality of each identified SR according to AMSTAR (a measurement tool to assess systematic reviews) and OQAQ (Oxman and Guyatt’s overview quality assessment questionnaire). Outcomes related to stroke rehabilitation were evaluated. SRs of high methodological quality (AMSTAR score ≥9 and OQAQ score ≥7) were graded using GRADE. Ultimately, acupuncture yields benefits in stroke rehabilitation (neurological function improvement: RR = 1.34; swallowing improvement: RR = 1.61, 1.49, 1.07; disability: SMD = 0.49 or 0.07). Poor evidentiary quality and insufficient information about harm led to weak recommendations. In conclusion, acupuncture may improve stroke rehabilitation, as the GRADE approach indicated a weak recommendation for acupuncture’s usage in this context. PMID:26560971

  13. A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

    ClinicalTrials.gov

    2015-03-02

    Adult Anaplastic Astrocytoma; Recurrent Grade III Glioma; Recurrent Grade IV Glioma; Adult Anaplastic Oligodendroglioma; Adult Brain Tumor; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Recurrent Adult Brain Tumor; Adult Anaplastic Oligoastrocytoma; Recurrent High Grade Glioma

  14. STI. DE-FG02-00ER1505 [Brief summary of 11th International Conference on Arabidopsis Research

    SciTech Connect

    2000-06-24

    The 11th International Conference on Arabidopsis Research was held in Madison, Wisconsin, June 24 through June 28, 2000. Arabidopsis thaliana has been the subject of genetic study for many years. However, during the last decade, the number of research laboratories using Arabidopsis as a model system has increased tremendously, and Arabidopsis is currently being used to study all aspects of plant biology. The rapid rate of progress in Arabidopsis research, including the completion of the genomic sequence, underscores the usefulness of holding a meeting every year. These conferences provide an important opportunity for the Arabidopsis community to interact and exchange information. The meeting opened with an evening keynote address on the global impact of plant biology, delivered by Richard Jefferson, the Executive Director of CAMBIA (Center for the Application of Molecular Biology to International Agriculture). This was followed by short updates from each of the NSF-funded Plant Genome groups. Many of these groups are carrying out projects that impact the Arabidopsis community. Each of the 17 platform sessions consisted of talks from two invited speakers followed by two short talks that were chosen from the submitted poster abstracts. A concerted effort was made to invite junior investigators, including graduate students and postdocs, to give these talks. Posters were available for viewing during three formal sessions, and, because the poster session was adjacent to the lecture hall, it was easy for participants to go back and forth between posters and lectures. Finally, a mixer and an informal banquet provided opportunities for participants to meet new people and renew acquaintances. Furthermore, the registration package included all lunches and dinners together in a cafeteria next to the posters and lecture hall, thus encouraging the meeting of established investigators with students and postdocs. The North American Arabidopsis Steering Committee (elected by

  15. High-grade metamorphism of ironstones in the Mesoarchaean of southwest Swaziland

    NASA Astrophysics Data System (ADS)

    Horváth, Péter; Reinhardt, Jürgen; Hofmann, Axel

    2014-08-01

    A sequence of high-grade rocks collectively referred to as Mkhondo Valley Metamorphic Suite is exposed around the Nhlangano Gneiss Dome in southwest Swaziland and also less extensively further north. Meta-ironstones are part of this sequence and have been studied specifically with two main objectives in mind, firstly, to test the hypothesis of the high-grade metamorphic sequence correlating with lower-grade Pongola-age rocks nearby, and secondly, to assess the potential of these meta-ironstones for retrieving P-T conditions of metamorphism. The studied ironstones contain substantial Al due to terrigenous clastic input and also include Mn-rich varieties. Three compositional groups of meta-ironstones can be distinguished: garnet-orthopyroxene-bearing ones, garnet-bearing, orthopyroxene-free ones, and a garnet-poor to garnet-free type. A comparison of bulk rock compositions between these high-grade meta-ironstones and low-grade Mn-poor to Mn-rich ironstones from the Mozaan Group supports a stratigraphic correlation. Pseudosection modelling demonstrates that aluminous meta-ironstones provide useful P-T constraints at high peak temperatures as they do not tend to produce significant amounts of melt, if any. The presence of Al is critical for introducing garnet to amphibolite and granulite-facies assemblages, which also allows to apply conventional thermobarometers. The combination of pseudosection modelling and conventional thermobarometry yielded peak metamorphic conditions of 850-890 °C at 7 to 8 kbar. These data are compatible with the ones obtained from associated metapelitic gneisses, except that the latter indicate decompression to lower pressure granulite-facies conditions. The petrological, structural and geochronological data from southwest Swaziland confirm major orogenic activity in the eastern Kaapvaal Craton during the Neo-Archaean.

  16. Feasibility of Using Bevacizumab With Radiation Therapy and Temozolomide in Newly Diagnosed High-Grade Glioma

    SciTech Connect

    Narayana, Ashwatha Golfinos, John G.; Fischer, Ingeborg; Raza, Shahzad; Kelly, Patrick M.D.; Parker, Erik; Knopp, Edmond A.; Medabalmi, Praveen; Zagzag, David; Eagan, Patricia; Gruber, Michael L.

    2008-10-01

    Introduction: Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), has shown promise in the treatment of patients with recurrent high-grade glioma. The purpose of this study is to test the feasibility of using bevacizumab with chemoradiation in the primary management of high-grade glioma. Methods and Materials: Fifteen patients with high-grade glioma were treated with involved field radiation therapy to a dose of 59.4 Gy at 1.8 Gy/fraction with bevacizumab 10 mg/kg on Days 14 and 28 and temozolomide 75 mg/m{sup 2}. Subsequently, bevacizumab 10 mg/kg was continued every 2 weeks with temozolomide 150 mg/m{sup 2} for 12 months. Changes in relative cerebral blood volume, perfusion-permeability index, and tumor volume measurement were measured to assess the therapeutic response. Immunohistochemistry for phosphorylated VEGF receptor 2 (pVEGFR2) was performed. Results: Thirteen patients (86.6%) completed the planned bevacizumab and chemoradiation therapy. Four Grade III/IV nonhematologic toxicities were seen. Radiographic responses were noted in 13 of 14 assessable patients (92.8%). The pVEGFR2 staining was seen in 7 of 8 patients (87.5%) at the time of initial diagnosis. Six patients have experienced relapse, 3 at the primary site and 3 as diffuse disease. One patient showed loss of pVEGFR2 expression at relapse. One-year progression-free survival and overall survival rates were 59.3% and 86.7%, respectively. Conclusion: Use of antiangiogenic therapy with radiation and temozolomide in the primary management of high-grade glioma is feasible. Perfusion imaging with relative cerebral blood volume, perfusion-permeability index, and pVEGFR2 expression may be used as a potential predictor of therapeutic response. Toxicities and patterns of relapse need to be monitored closely.

  17. A Resource Bulletin for Teachers of English, Grade Eleven.

    ERIC Educational Resources Information Center

    Baltimore County Public Schools, Towson, MD.

    Beginning with a look at contemporary American materials (both literary and non-literary), this 11th-grade curriculum guide proceeds with a chronological, thematic approach to American literature, focusing on such units as "The First Frontier--Establishment of the American Dream,""The American Dream on Trial,""The Dream and Reality," and "Toward…

  18. A CURRICULUM FOR ENGLISH, STUDENT PACKET, GRADE 11.

    ERIC Educational Resources Information Center

    Nebraska Univ., Lincoln. Curriculum Development Center.

    THE 11TH-GRADE COURSE OF STUDY IN AMERICAN LITERATURE PRESENTED IN THE STUDENT PACKET FOR THE NEBRASKA ENGLISH CURRICULUM BEGINS WITH A UNIT ENTITLED "INDIVIDUALISM AND IDEALISM" IN WHICH STUDENTS ANALYZE SPIRITUAL AUTOBIOGRAPHIES BY EMERSON, THOREAU, WHITMAN, AND DICKINSON. NEXT, THE THEME OF SIN AND LONELINESS AS IT LIMITS INDIVIDUALISM IS…

  19. Simultaneous Integrated Boost Intensity-Modulated Radiotherapy in Patients With High-Grade Gliomas

    SciTech Connect

    Cho, Kwan Ho; Kim, Joo-Young; Lee, Seung Hoon

    2010-10-01

    Purpose: We analyzed outcomes of simultaneous integrated boost (SIB) intensity-modulated radiotherapy (IMRT) in patients with high-grade gliomas, compared with a literature review. Methods and Materials: Forty consecutive patients (WHO grade III, 14 patients; grade IV, 26 patients) treated with SIB-IMRT were analyzed. A dose of 2.0 Gy was delivered to the planning target volume with a SIB of 0.4 Gy to the gross tumor volume with a total dose of 60 Gy to the gross tumor volume and 50 Gy to the planning target volume in 25 fractions during 5 weeks. Twenty patients received temozolomide chemotherapy. Results: At a median follow-up of 13.4 months (range, 3.7-55.9 months), median survival was 14.8 months. One- and 2-year survival rates were 78% and 65%, respectively, for patients with grade III tumors and 56% and 31%, respectively, for patients with grade IV tumors. Age ({<=}50 vs. >50), grade (III vs. IV), subtype (astrocytoma vs. oligodendroglioma or mixed), and a Zubrod performance score (0-1 vs. >2) were predictive of survival. Of 25 (63%) patients who had recurrences, 17 patients had local failure, 9 patients had regional failure, and 1 patient had distant metastasis. Toxicities were acceptable. Conclusions: SIB-IMRT with the dose/fractionation used in this study is feasible and safe, with a survival outcome similar to the historical control. The shortening of treatment time by using SIB-IMRT may be of value, although further investigation is warranted to prove its survival advantage.

  20. Body mass index, serum total cholesterol, and risk of gastric high-grade dysplasia

    PubMed Central

    Huang, Ya-Kai; Kang, Wei-Ming; Ma, Zhi-Qiang; Liu, Yu-Qin; Zhou, Li; Yu, Jian-Chun

    2016-01-01

    Abstract Obesity is related to an increased risk of gastric cardia cancer. However, the influences of excess body weight and serum total cholesterol on the risk of gastric high-grade dysplasia have not been fully characterized. A case–control study was conducted to explore the relationships between body mass index (BMI), serum total cholesterol level, and the risk of gastric high-grade dysplasia in Chinese adults. A total of 893 consecutive patients with gastric high-grade dysplasia (537 men and 356 women) and 902 controls (543 men and 359 women) were enrolled from January 2000 to October 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated, and a multivariate analysis was conducted. After adjusting for age, alcohol consumption, smoking status, family history of gastric cancer or esophageal cancer, and serum total cholesterol level, a BMI ranging from 27.5 to 29.9 was significantly related to an increased risk of gastric high-grade dysplasia in both men (adjusted OR = 1.87, 95% CI = 1.24–2.81) and women (adjusted OR = 2.72, 95% CI = 1.44–5.16). The 2 highest BMI categories (27.5–29.9 and ≥30.0) were identified as risk factors for gastric cardia high-grade dysplasia in both men (BMI = 27.5–29.9: adjusted OR = 1.78, 95% CI = 1.02–3.10; BMI ≥ 30.0: adjusted OR = 2.54, 95% CI = 1.27–5.08) and women (BMI = 27.5–29.9: adjusted OR = 2.88, 95% CI = 1.27–6.55; BMI ≥ 30.0: adjusted OR = 2.77, 95% CI = 1.36–5.64), whereas only a BMI ranging from 27.5 to 29.9 was a risk factor for gastric noncardia high-grade dysplasia in both men (adjusted OR = 1.98, 95% CI = 1.25–3.14) and women (adjusted OR = 2.88, 95% CI = 1.43–5.81). In addition, higher serum total cholesterol was associated with an increased risk of gastric noncardia high-grade dysplasia (adjusted OR = 1.83, 95% CI = 1.25–2.69) in women. Increased BMI was associated with an increased risk

  1. Interstitial radiogold implantation for the treatment of recurrent high-grade gliomas

    SciTech Connect

    Larson, G.L.; Wilbanks, J.H.; Dennis, W.S.; Permenter, W.D.; Easley, J.D. )

    1990-07-01

    Thirty-three patients were treated at the Methodist Hospital, Baylor College of Medicine (Houston) between 1983 and 1987, for high-grade gliomas which had recurred after conventional external-beam radiation therapy. The mean dose to the tumor volume from the external-beam therapy was 5800 cGy. Thirteen patients had recurrent astrocytoma Grade 4 (glioblastoma), whereas 20 had recurrent astrocytoma Grade 3 (anaplastic astrocytoma). All patients were treated for their recurrence by the combination of reexcision of as much of the tumor mass as was technically feasible and intraoperative radiogold (198Au) seed implantation of the residual tumor and/or tumor bed. The mean dose to the tumor volume from the implant was 4000 cGy. For the 13 patients treated for recurrent glioblastoma the 1-year, 2-year, and 3-year survival rates were 46%, 15%, and 8%, respectively. For the 20 patients treated for recurrent anaplastic astrocytoma the 1-year, 2-year, and 3-year survival rates were 75%, 50%, and 15%, respectively. Survival was measured from the time of implant. The median survival for patients with glioblastoma was 9 months. The median survival for patients with anaplastic astrocytoma was 17 months. One patient died in the immediate postoperative period from a gastrointestinal bleed. No patient required reoperation for radiation necrosis. The authors believe that this technique is an effective treatment for patients with high-grade gliomas recurring after external-beam radiation therapy, and are now including interstitial irradiation in the initial management of selected patients with high-grade gliomas.

  2. Utilization of Selected Simulation Games to Foster Improved Attitudes Among 11th Grade Students Engaged in the Study of Social Studies.

    ERIC Educational Resources Information Center

    Festa, Dominick A.

    A project to determine the effectiveness of a program designed to create more positive attitudes among students studying social studies through use of simulation games is described in this dissertation. The purposes of the project were to describe the design and implementation of a plan for such a program and to determine whether simulation games…

  3. High School Chemistry Instructional Practices and Their Association with College Chemistry Grades

    NASA Astrophysics Data System (ADS)

    Tai, Robert H.; Sadler, Philip M.

    2007-06-01

    This large-scale survey study looks for connections between high school chemistry classroom instructional practices and the performance of these students in introductory college chemistry. Based on survey data collected from over 3000 students in 31 different colleges and universities, the results indicate that students who reported higher frequencies of high school chemistry experiences such as peer teaching and “everyday” (i.e., common) examples, on the average, earned higher college grades. However, students who reported higher frequencies of demonstrations and individual work among other indicators, on the average, earned lower grades. Overall, the results suggest that peer engagement in high school chemistry may be associated with success in college chemistry.

  4. Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy

    ClinicalTrials.gov

    2014-05-05

    Childhood High-grade Cerebellar Astrocytoma; Childhood High-grade Cerebral Astrocytoma; Recurrent Childhood Anaplastic Astrocytoma; Recurrent Childhood Anaplastic Oligoastrocytoma; Recurrent Childhood Anaplastic Oligodendroglioma; Recurrent Childhood Brain Tumor; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Glioblastoma; Recurrent Childhood Visual Pathway and Hypothalamic Glioma

  5. High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer.

    PubMed

    Hou, June Y; Smotkin, David; Grossberg, Robert; Suhrland, Mark; Levine, Rebecca; Smith, Harriet O; Negassa, Abdissa; McAndrew, Thomas C; Einstein, Mark H

    2012-06-01

    There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered. PMID:22466085

  6. EDITORIAL: Proceedings of the 11th Gravitational Wave Data Analysis Workshop, Potsdam, Germany, 18 21 December 2006

    NASA Astrophysics Data System (ADS)

    Krishnan, B.; Papa, M. A.; Schutz, B. F.

    2007-10-01

    The 11th Gravitational Wave Data Analysis Workshop (GWDAW11) comes in the middle of the fifth science run (S5) of the LIGO detectors, after a full year of data-taking at design sensitivity. LIGO is starting to probe astrophysically plausible scenarios for the emission of detectable gravitational wave signals. In the absence of a detection, the upper limits on the strength of gravitational waves are beginning to add information to what was previously known from electromagnetic observations. One of the highlights of this workshop was the presentation by the LIGO Scientific Collaboration of a search for continuous waves from the Crab pulsar. Gravitational wave emission is constrained by the measured spindown measurements for the object: no more energy can go into gravitational waves than that which is lost by pulsar spindown. For most known pulsars this spindown upper limit on the strength of gravitational radiation is orders of magnitude higher than the upper limits that can be set with current gravitational wave observations. However for the Crab pulsar the gravitational wave observations which coherently combine about 9 months of data from the network of S5 LIGO detectors constrain the gravitational wave emission more strongly than the electromagnetic observations do. The gravitational wave upper limit also constrains the tri-axial ellipticity that this young pulsar could have supported since its crust solidified a thousand years ago. The Virgo detector is in the final stages of commissioning with several engineering runs completed. The TAMA detector's low frequency performance is being enhanced and another data run is foreseen by the end of 2007. The IGEC2 Collaboration presents results from the analysis of 131 days of data in coincidence among the three bar detectors EXPLORER, AURIGA and NAUTILUS. Studies are underway to analyze data in coincidence among bar and interferometer networks. Space-based detectors are receiving more attention, with the LISA Pathfinder

  7. Specific localization of thallium 201 in human high-grade astrocytoma by microautoradiography

    SciTech Connect

    Mountz, J.M.; Raymond, P.A.; McKeever, P.E.; Modell, J.G.; Hood, T.W.; Barthel, L.K.; Stafford-Schuck, K.A. )

    1989-07-15

    The ability to accurately distinguish remaining or recurrent high-grade astrocytoma from necrosis or edema following treatment is essential to optimal patient management. Thallium 201 planar gamma-camera imaging has been shown to be helpful in detecting recurrent high-grade astrocytoma; however, due to tissue heterogeneity adjacent to and within tumor, the cellular specificity and quantification of 201Tl uptake are largely unknown. In order to determine which tissues are responsible for the radioisotope uptake, microautoradiographic techniques were used to examine multiple tissue sections from five patients with high-grade astrocytoma. Each patient received 5 mCi of 201Tl i.v. 1 h prior to tumor removal. Additionally, all patients received computerized tomographic and 201Tl planar gamma-camera scans prior to surgery. Following surgery, the excised tissue specimens were tentatively classified by gross pathological examination and then immediately processed for dry mount autoradiography; grain density was determined over regions containing tumor, adjacent and uninvolved brain tissue, necrotic tissue, and background. Highly significant differences were found in grain densities (201Tl uptake) between tumor and uninvolved brain tissue, as well as between uninvolved brain tissue and necrotic tissue; there was no significant difference between background grain density and that in necrotic tissue. Mean grain densities (grains/cm2 +/- 1 SD) across patients were: tumor, 102 +/- 23; adjacent, uninvolved brain tissue, 29 +/- 11; necrotic tissue, 6.2 +/- 1.1; and background, 7.0 +/- 4.1. We conclude that the ability of 201Tl to selectively image high-grade astrocytoma is due to its preferential uptake into tumor cells.

  8. Effects of Computer-Assisted Instruction (CAI) on 11th Graders' Attitudes to Biology and CAI and Understanding of Reproduction in Plants and Animals.

    ERIC Educational Resources Information Center

    Soyibo, Kola; Hudson, Ann

    2000-01-01

    Investigates whether the use of the combination of lecture, discussion, and computer-assisted instruction (CAI) significantly improved students' attitudes toward biology and their understanding of reproduction in plants and animals. Studies grade 11 Jamaican female students (n=77) from two traditional high schools in Kingston. (Contains 19…

  9. Variation of Mechanical Properties of High RRR And Reactor Grade Niobium With Heat Treatments

    SciTech Connect

    Ganapati Myneni; H. Umezawa

    2003-06-01

    Superconducting rf cavities used as accelerating structures in particle accelerators are made from high purity niobium with residual resistance ratios greater than 250. Reactor grade niobium is also used to make wave-guide and/or end group components for these accelerating structures. The major impurities in this type of niobium are interstitially dissolved gases such as hydrogen, nitrogen, and oxygen in addition to carbon. After fabricating the niobium accelerating structures, they are subjected to heat treatments for several hours in vacuum at temperatures of up to 900 C for degassing hydrogen or up to 1400 C for improving the thermal conductivity of niobium considerably. These heat treatments are affecting the mechanical properties of niobium drastically. In this paper the variation of the mechanical properties of high purity and reactor grade niobium with heat treatments in a vacuum of {approx} 10{sup -6} Torr and temperatures from 600 C to 1250 C for periods of 10 to 6 hours are presented.

  10. Normal tissue tolerance for high-grade gliomas: is it an issue?

    PubMed

    Morris, David E; Kimple, Randall J

    2009-07-01

    In this article, we address the currently accepted dose tolerance parameters for the treatment of high-grade gliomas. The issue of normal tissue tolerance is becoming increasingly important because of the long-term survival of a significant subset of young, good performance status patients and the use of hypofractionated regimens for elderly patients with poor performance status. In addition, we address relevant clinical endpoints including clinical, pathologic, and radiographic changes and highlight the difficulty in discriminating between tumor-related and treatment-related effects. Finally, we review relevant clinical trials addressing issues of dose and/or volume parameters. Future trials for patients with high-grade gliomas should consider the inclusion of a prospective evaluation of neurocognitive function and imaging correlates of the brain to assist in the prediction, prevention, and treatment of radiation-induced damage of normal brain tissue. PMID:19464634

  11. Diagnosis of High-Grade Osteosarcoma by Radiology and Cytology: A Retrospective Study of 52 Cases

    PubMed Central

    Skoog, Lambert; Unni, Krishnan K.; Bertoni, Franco; Brosjö, Otte; Kreicbergs, Andris

    2004-01-01

    The diagnostic value of combined radiology and fine needle aspiration cytology (FNAC) was retrospectively assessed in a consecutive series of 52 patients with high-grade osteosarcoma. The series was divided into typical and atypical osteosarcomas according to radiological features and site. Thirty-two of 33 radiologically typical osteosarcoma cases were correctly diagnosed by cytology; one lesion was diagnosed as sarcoma NOS. Nineteen osteosarcoma cases were radiographically atypical. Six of these were diagnosed as osteosarcoma and another six as sarcoma NOS. In three cases another type of sarcoma was suggested. One case was falsely classified as benign. FNAC of three cases were non-diagnostic. Overall, the diagnostic difficulties pertained to the radiologically atypical cases. Notably, four of these also posed considerable difficulties in the histopathological assessment prompting external consultation. Our study suggests that open biopsy can be obviated in high-grade osteosarcomas exhibiting typical radiological features, i.e., in two-thirds. PMID:18521391

  12. Rare earth element patterns in Archean high-grade metasediments and their tectonic significance

    NASA Technical Reports Server (NTRS)

    Taylor, Stuart Ross; Rudnick, Roberta L.; Mclennan, Scott M.; Eriksson, Kenneth A.

    1986-01-01

    REE data on metasedimentary rocks from two different types of high-grade Archean terrains are presented and analyzed. The value of REEs as indicators of crustal evolution is explained; the three geologic settings (in North America, Southern Africa, and Australia) from which the samples were obtained are described; and the data are presented in extensive tables and graphs and discussed in terms of metamorphic effects, the role of accessory phases, provenance, and tectonic implications (recycling, the previous extent of high-grade terrains, and a model of Archean crustal growth). The diversity of REE patterns in shallow-shelf metasediments is attributed to local provenance, while the Eu-depleted post-Archean patterns are associated with K-rich plutons from small, stable early Archean terrains.

  13. Forming high efficiency silicon solar cells using density-graded anti-reflection surfaces

    DOEpatents

    Yuan, Hao-Chih; Branz, Howard M.; Page, Matthew R.

    2014-09-09

    A method (50) is provided for processing a graded-density AR silicon surface (14) to provide effective surface passivation. The method (50) includes positioning a substrate or wafer (12) with a silicon surface (14) in a reaction or processing chamber (42). The silicon surface (14) has been processed (52) to be an AR surface with a density gradient or region of black silicon. The method (50) continues with heating (54) the chamber (42) to a high temperature for both doping and surface passivation. The method (50) includes forming (58), with a dopant-containing precursor in contact with the silicon surface (14) of the substrate (12), an emitter junction (16) proximate to the silicon surface (14) by doping the substrate (12). The method (50) further includes, while the chamber is maintained at the high or raised temperature, forming (62) a passivation layer (19) on the graded-density silicon anti-reflection surface (14).

  14. Forming high-efficiency silicon solar cells using density-graded anti-reflection surfaces

    DOEpatents

    Yuan, Hao-Chih; Branz, Howard M.; Page, Matthew R.

    2015-07-07

    A method (50) is provided for processing a graded-density AR silicon surface (14) to provide effective surface passivation. The method (50) includes positioning a substrate or wafer (12) with a silicon surface (14) in a reaction or processing chamber (42). The silicon surface (14) has been processed (52) to be an AR surface with a density gradient or region of black silicon. The method (50) continues with heating (54) the chamber (42) to a high temperature for both doping and surface passivation. The method (50) includes forming (58), with a dopant-containing precursor in contact with the silicon surface (14) of the substrate (12), an emitter junction (16) proximate to the silicon surface (14) by doping the substrate (12). The method (50) further includes, while the chamber is maintained at the high or raised temperature, forming (62) a passivation layer (19) on the graded-density silicon anti-reflection surface (14).

  15. High-grade astrocytoma (Glioblastoma Multiforme) in an Atlantic spotted dolphin (Stenella frontalis).

    PubMed

    Díaz-Delgado, J; Sacchini, S; Suárez-Bonnet, A; Sierra, E; Arbelo, M; Espinosa, A; Rodríguez-Grau Bassas, E; Mompeo, B; Pérez, L; Fernández, A

    2015-01-01

    This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 × 2.5 × 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells. These often palisaded along serpentine foci of necrosis and were surrounded by prominent vessels. Immunohistochemically, the neoplastic cells expressed glial fibrillary acidic protein, but not vimentin, S100 protein, neuron-specific enolase or neurofilament protein. A diagnosis of high-grade astrocytoma was made and this represents the first description of a glioma in a cetacean species. PMID:25728810

  16. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

    PubMed

    McPherson, Andrew; Roth, Andrew; Laks, Emma; Masud, Tehmina; Bashashati, Ali; Zhang, Allen W; Ha, Gavin; Biele, Justina; Yap, Damian; Wan, Adrian; Prentice, Leah M; Khattra, Jaswinder; Smith, Maia A; Nielsen, Cydney B; Mullaly, Sarah C; Kalloger, Steve; Karnezis, Anthony; Shumansky, Karey; Siu, Celia; Rosner, Jamie; Chan, Hector Li; Ho, Julie; Melnyk, Nataliya; Senz, Janine; Yang, Winnie; Moore, Richard; Mungall, Andrew J; Marra, Marco A; Bouchard-Côté, Alexandre; Gilks, C Blake; Huntsman, David G; McAlpine, Jessica N; Aparicio, Samuel; Shah, Sohrab P

    2016-07-01

    We performed phylogenetic analysis of high-grade serous ovarian cancers (68 samples from seven patients), identifying constituent clones and quantifying their relative abundances at multiple intraperitoneal sites. Through whole-genome and single-nucleus sequencing, we identified evolutionary features including mutation loss, convergence of the structural genome and temporal activation of mutational processes that patterned clonal progression. We then determined the precise clonal mixtures comprising each tumor sample. The majority of sites were clonally pure or composed of clones from a single phylogenetic clade. However, each patient contained at least one site composed of polyphyletic clones. Five patients exhibited monoclonal and unidirectional seeding from the ovary to intraperitoneal sites, and two patients demonstrated polyclonal spread and reseeding. Our findings indicate that at least two distinct modes of intraperitoneal spread operate in clonal dissemination and highlight the distribution of migratory potential over clonal populations comprising high-grade serous ovarian cancers. PMID:27182968

  17. Malignant transformation of a high-grade osteoblastoma of the petrous apex with subcutaneous metastasis.

    PubMed

    Kraft, Casey T; Morrison, Robert J; Arts, H Alexander

    2016-06-01

    We describe the clinical presentation, management, and pathologic findings in a case of osteosarcoma of the petrous apex with an atypical metastasis to the lower abdominal wall. We retrospectively reviewed the record of a 49-year-old man who was diagnosed with a right petrous apex lesion, which biopsy identified as a high-grade osteoblastoma. After two attempts at en bloc resection were not curative, radiation and chemotherapy were recommended. The patient subsequently developed a cutaneous lower abdominal mass that was diagnosed as an osteosarcoma. Meanwhile, the petrous apex tumor continued to grow despite treatment until the patient died from the burden of disease. Temporal bone osteoblastomas and osteosarcomas are both extremely rare, and they can be difficult to differentiate histologically. Our case illustrates this difficulty and demonstrates the possibility of a high-grade osteoblastoma's malignant conversion to an osteosarcoma. PMID:27304442

  18. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.

    PubMed

    Bowtell, David D; Böhm, Steffen; Ahmed, Ahmed A; Aspuria, Paul-Joseph; Bast, Robert C; Beral, Valerie; Berek, Jonathan S; Birrer, Michael J; Blagden, Sarah; Bookman, Michael A; Brenton, James D; Chiappinelli, Katherine B; Martins, Filipe Correia; Coukos, George; Drapkin, Ronny; Edmondson, Richard; Fotopoulou, Christina; Gabra, Hani; Galon, Jérôme; Gourley, Charlie; Heong, Valerie; Huntsman, David G; Iwanicki, Marcin; Karlan, Beth Y; Kaye, Allyson; Lengyel, Ernst; Levine, Douglas A; Lu, Karen H; McNeish, Iain A; Menon, Usha; Narod, Steven A; Nelson, Brad H; Nephew, Kenneth P; Pharoah, Paul; Powell, Daniel J; Ramos, Pilar; Romero, Iris L; Scott, Clare L; Sood, Anil K; Stronach, Euan A; Balkwill, Frances R

    2015-11-01

    High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015. PMID:26493647

  19. Total enbloc spondylectomy for metastatic high grade spinal tumors: Early results

    PubMed Central

    Patil, Sanganagouda S; Nene, Abhay M

    2016-01-01

    Background: High grade metastatic spinal tumors are most common and are invasive. These patients can succumb to disease progression if not treated timely. Although considered as invasive and morbid, total enbloc spondylectomy (TES) in selected cases has better survival rates. The authors describe the results of TES for high grade metastatic spinal tumors. Materials and Methods: Five patients (four females and one male) underwent TES for solitary metastatic vertebral lesion between November 2012 and January 2014. These patients presented to us with spinal instability, unrelenting severe spinal pain and/or with severe progressive radiculopathy. Average age was 46.2 years (range 39–62 years). After complete investigations, computed tomography scan, magnetic resonance imaging scan and positron emission tomography (PET) scan, it was confirmed that these patients had high grade solitary vertebral metastatic tumor. Results: Average duration of followup was 18 months (range 16–20 months). The average preoperative visual analog scale score of 9.4 (range 9–10) improved to 2 (range 1–4) at last followup. Average blood loss was 1440 mL (range 1000–2000 mL). Average duration of surgery was 198 min (range 180–240 min). Significant pain relief was noticed in each patient in the immediate postoperative period and during followups. These patients attained complete functional activities of daily living with in a month. The imaging showed implants in situ, no recurrence of tumor, and no activity on PET scan at the final followup. Conclusion: The present series shows favorable short term results of TES for solitary, metastatic, high grade vertebral body tumors by a team approach. PMID:27512215

  20. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

    PubMed Central

    Bowtell, David D.; Böhm, Steffen; Ahmed, Ahmed A.; Aspuria, Paul-Joseph; Bast, Robert C.; Beral, Valerie; Berek, Jonathan S.; Birrer, Michael J.; Blagden, Sarah; Bookman, Michael A.; Brenton, James; Chiappinelli, Katherine B.; Martins, Filipe Correia; Coukos, George; Drapkin, Ronny; Edmondson, Richard; Fotopoulou, Christina; Gabra, Hani; Galon, Jérôme; Gourley, Charlie; Heong, Valerie; Huntsman, David G.; Iwanicki, Marcin; Karlan, Beth Y.; Kaye, Allyson; Lengyel, Ernst; Levine, Douglas A.; Lu, Karen H.; McNeish, Iain A.; Menon, Usha; Narod, Steve A.; Nelson, Brad H.; Nephew, Kenneth P.; Pharoah, Paul; Powell, Daniel J.; Ramos, Pilar; Romero, Iris L.; Scott, Clare L.; Sood, Anil K.; Stronach, Euan A.; Balkwill, Frances R.

    2016-01-01

    High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This ‘roadmap’ for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015. PMID:26493647

  1. Toppling high-grade pulmonary neuroendocrine tumors with a DLL3-targeted trojan horse.

    PubMed

    Dylla, Scott J

    2016-03-01

    Delta-like protein 3 (DLL3) is a novel and tractable tumor-initiating cell-associated target for the antibody-drug conjugate SC16LD6.5 in high-grade pulmonary neuroendocrine tumors. Elevated expression of DLL3, an inhibitor of Notch pathway activation, marks the second recent observation that impairment of Notch receptor signaling may play a critical role in neuroendocrine tumorigenesis. PMID:27308627

  2. Evaluation of the hybrid capture 2 assay for detecting anal high-grade dysplasia.

    PubMed

    Goldstone, Stephen E; Lowe, Brian; Rothmann, Thomas; Nazarenko, Irina

    2012-10-01

    Hybrid Capture 2 (HC2) Human Papillomavirus (HPV) DNA Test® is FDA approved and is a proven aid in detecting HPV infections of the cervix and as an aid in diagnosing, with cytology, cervical disease. A prospective feasibility study was conducted to determine if HC2 testing has utility when screening for high-grade anal dysplasia (AIN2+). We enrolled 298 patients (45% HIV+) who had AIN2+ screening with cytology, histology and HC2 testing for two specimens: a swab into liquid-based cytology medium and either a swab or a brush collection in specimen transport medium (STM). High-resolution anoscopy was performed on all patients with biopsy of AIN2+ suspicious lesions. Cytology was benign (42%), atypical squamous cells of undetermined significance (30%), low-grade squamous intraepithelial lesion (18%), high-grade squamous intraepithelial lesion (1%), ASCUS possibly high-grade dysplasia (1.7%) and nondiagnostic (7%) and 36% had AIN2+ histology. Sensitivity and specificity for predicting AIN2+ histology for any abnormal cytology were 77 and 52%, whereas HC2 sensitivity and specificity were 91 and 40% (p = 0.005 for sensitivity), respectively. There was no significant difference in HC2 sensitivity or specificity between brush and swab or STM and residual cells from cytology. AIN2+ was found in 20% of patients with benign cytology. Only nine AIN2+ specimens were HC2-. This prospective study indicates that HC2 may be useful when screening for anal dysplasia; however, a larger study is recommended. PMID:22234750

  3. An Examination of the Correlation between Ninth Grade Mathematics Grades and Student Performance on the Mathematics Portion of the California High School Exit Examination

    ERIC Educational Resources Information Center

    Steffan, Andrea Lynn

    2010-01-01

    This study examines the relationship between ninth graders' math course grades (passing or failing) and future performance on the California High School Exit Examination (CAHSEE). Although correlative data is not predictive, it is able to give a sense of which students one can expect to be successful and which students are more likely to benefit…

  4. Prognostic Relevance of Histomolecular Classification of Diffuse Adult High-Grade Gliomas with Necrosis.

    PubMed

    Figarella-Branger, Dominique; Mokhtari, Karima; Colin, Carole; Uro-Coste, Emmanuelle; Jouvet, Anne; Dehais, Caroline; Carpentier, Catherine; Villa, Chiara; Maurage, Claude-Alain; Eimer, Sandrine; Polivka, Marc; Vignaud, Jean-Michel; Laquerriere, Annie; Sevestre, Henri; Lechapt-Zalcman, Emmanuelle; Quintin-Roué, Isabelle; Aubriot-Lorton, Marie-Hélène; Diebold, Marie-Danièle; Viennet, Gabriel; Adam, Clovis; Loussouarn, Delphine; Michalak, Sophie; Rigau, Valérie; Heitzmann, Anne; Vandenbos, Fanny; Forest, Fabien; Chiforeanu, Danchristian; Tortel, Marie-Claire; Labrousse, François; Chenard, Marie-Pierre; Nguyen, Anh Tuan; Varlet, Pascale; Kemeny, Jean Louis; Levillain, Pierre-Marie; Cazals-Hatem, Dominique; Richard, Pomone; Delattre, Jean-Yves

    2015-07-01

    Diffuse adult high-grade gliomas (HGGs) with necrosis encompass anaplastic oligodendrogliomas (AOs) with necrosis (grade III), glioblastomas (GBM, grade IV) and glioblastomas with an oligodendroglial component (GBMO, grade IV). Here, we aimed to search for prognostic relevance of histological classification and molecular alterations of these tumors. About 210 patients were included (63 AO, 56 GBM and 91 GBMO). GBMO group was split into "anaplastic oligoastrocytoma (AOA) with necrosis grade IV/GBMO," restricted to tumors showing intermingled astrocytic and oligodendroglial component, and "GBM/GBMO" based on tumors presenting oligodendroglial foci and features of GBM. Genomic arrays, IDH1 R132H expression analyses and IDH direct sequencing were performed. 1p/19q co-deletion characterized AO, whereas no IDH1 R132H expression and intact 1p/19q characterized both GBM and GBM/GBMO. AOA with necrosis/GBMO mainly demonstrated IDH1 R132H expression and intact 1p/19q. Other IDH1 or IDH2 mutations were extremely rare. Both histological and molecular classifications were predictive of progression free survival (PFS) and overall survival (OS) (P < 10(-4) ). Diffuse adult HGGs with necrosis can be split into three histomolecular groups of prognostic relevance: 1p/19q co-deleted AO, IDH1 R132H-GBM and 1p/19q intact IDH1 R132H+ gliomas that might be classified as IDH1 R132H+ GBM. Because of histomolecular heterogeneity, we suggest to remove the name GBMO. PMID:25407774

  5. ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas.

    PubMed

    Ku, Min-Chi; Edes, Inan; Bendix, Ivo; Pohlmann, Andreas; Waiczies, Helmar; Prozorovski, Tim; Günther, Martin; Martin, Conrad; Pagès, Gilles; Wolf, Susanne A; Kettenmann, Helmut; Uckert, Wolfgang; Niendorf, Thoralf; Waiczies, Sonia

    2016-08-01

    Glioma regression requires the recruitment of potent antitumor immune cells into the tumor microenvironment. Dendritic cells (DC) play a role in immune responses to these tumors. The fact that DC vaccines do not effectively combat high-grade gliomas, however, suggests that DCs need to be genetically modified specifically to promote their migration to tumor relevant sites. Previously, we identified extracellular signal-regulated kinase (ERK1) as a regulator of DC immunogenicity and brain autoimmunity. In the current study, we made use of modern magnetic resonance methods to study the role of ERK1 in regulating DC migration and tumor progression in a model of high-grade glioma. We found that ERK1-deficient mice are more resistant to the development of gliomas, and tumor growth in these mice is accompanied by a higher infiltration of leukocytes. ERK1-deficient DCs exhibit an increase in migration that is associated with sustained Cdc42 activation and increased expression of actin-associated cytoskeleton-organizing proteins. We also demonstrated that ERK1 deletion potentiates DC vaccination and provides a survival advantage in high-grade gliomas. Considering the therapeutic significance of these results, we propose ERK1-deleted DC vaccines as an additional means of eradicating resilient tumor cells and preventing tumor recurrence. Mol Cancer Ther; 15(8); 1975-87. ©2016 AACR. PMID:27256374

  6. Inborn Errors of Metabolism: the metabolome is our world. Presidential address for the 11th International Congress of Inborn Errors of Metabolism (ICIEM).

    PubMed

    McCabe, Edward R B

    2010-05-01

    Thank you for honoring me by allowing me to serve as president of the 11th International Congress of Inborn Errors of Metabolism (ICIEM). The science brought by the IEM community to the Congress was quite impressive and demonstrated the quality of research within this community. In this address, I will consider briefly the history of IEMs to determine how we have arrived where we are, and will spend more time ascertaining our place in the current biomedical community and our role in determining the future of personalized medicine. In the 1950s-1970s new tools were added to expand our ability to interrogate the metabolome and the result was an explosive increase in the number of IEMs. This set the stage for expanded newborn screening (NBS) by tandem mass spectrometry (MS/MS) to identify these patients and to intervene pre-symptomatically. The complexity of the metabolome has led us to utilize the mathematical algorithms of systems biology to reduce high dimensionality data to low dimensionality output. However, the metabolome does not exist in isolation and we must learn how to integrate the metabolome with other xomics. The metabolome is our world and the IEM community has much to share with the broader xomics communities by integrating what we have learned with the other xomics communities. They are seeking access to the metabolome as a closer measure of phenotype, and we are already extremely comfortable and competent in the metabolomic space. But we should not be insular in our occupation of this space. NBS should be the model for personalized medicine, because it is already functioning as testing system for predictive, preventive and personalized care. We have been working in the area of NBS for nearly a half century and have many lessons learned that will be valuable to the practitioners of personalized medicine - lessons that they should not have to rediscover. We must embrace the international IEM community to meet population trends and to improve the care

  7. Diagnosis and Management of High-Grade Pancreatic Trauma: Report of 14 Cases.

    PubMed

    Bao, Wan-Yuan; She, Gang; Duan, Yun-Fei; Liu, Sheng-Yong; Sun, Dong-Lin; Yang, Yue; Zhu, Feng

    2015-12-01

    The aim of this study was to review the diagnosis and operative management of cases of high-grade pancreatic trauma. A retrospective analysis was performed on 14 patients treated for high-grade pancreatic trauma at our institution between December 2008 and November 2013. The patients were treated for injuries resulting from blunt abdominal trauma. The main clinical data of the patients was analyzed, including time to diagnosis, initial serum amylase level, ultrasonography and abdominal computed tomography (CT) findings, pancreatic injury severity as scored according to the American Association for the Surgery of Trauma Organ Injury Scale, injury to other organs, operative treatment method, postoperative complications, and patient outcome. All 14 patients were diagnosed with severe (≥ grade III) pancreatic trauma. Diagnosis was confirmed in all seven hemodynamically stable patients that underwent CT and in 9/13 patients receiving ultrasound examination. All patients underwent surgical operations, including emergency pancreaticoduodenectomy (n = 8), splenectomy with distal pancreatectomy (n = 3), spleen-preserving distal pancreatectomy (n = 1), medial pancreatectomy with Roux-en-Y pancreaticojejunostomy (n = 1), and peripancreatic debridement and drainage (n = 1). Diagnosis was delayed beyond 24 h in two patients, both of whom underwent reoperative peripancreatic debridement and drainage, with one death. The complications included pancreatic fistula (n = 8), peripancreatic abscess (n = 2), hepatic artery hemorrhage (n = 1), gastrointestinal bleeding (n = 1), and intra-abdominal abscess (n = 1). CT is the most reliable method for diagnosing high-grade pancreatic trauma. Aggressive surgical therapy including pancreaticoduodenectomy is acceptable in hemodynamically stable patients. PMID:27011541

  8. Preoperative Patient Reported Mental Health is Associated with High Grade Complications after Radical Cystectomy

    PubMed Central

    Sharma, Pranav; Henriksen, Carl H.; Zargar-Shoshtari, Kamran; Xin, Ren; Poch, Michael A.; Pow-Sang, Julio M.; Sexton, Wade J.; Spiess, Philippe E.; Gilbert, Scott M.

    2016-01-01

    Purpose Psychological distress has been associated with an impaired immune response and poor wound healing. We hypothesized that preoperative patient reported mental health would be associated with high grade 30-day complications after radical cystectomy. Materials and Methods We retrospectively identified patients who underwent radical cystectomy for bladder cancer who completed Short Form 12 (SF-12) surveys for self-assessment of health status less than 6 months before surgery. Median physical and mental composite scores were calculated. An expert model including known predictors of postoperative high grade complications was developed, and SF-12 physical composite score and mental composite score were added to determine their association with this end point. Results From January 2010 to August 2014, 472 patients underwent radical cystectomy for bladder cancer, of whom 274 (58.1%) completed preoperative SF-12 questionnaires. Responders were more likely to be white (p=0.024), have higher preoperative albumin (p=0.037), receive neoadjuvant chemotherapy (p=0.002), have pT3/T4 disease (p=0.044) and have positive soft tissue surgical margins (p=0.006). Median SF-12 physical composite score was 43.1 (IQR 33.0–51.5) and mental composite score was 48.5 (IQR 39.5–54.7) in responders. Overall 46 (16.8%) responders experienced a high grade 30-day complication. Patients with a high grade complication had a lower preoperative median SF-12 mental composite score (44.8 vs 49.8, p=0.004) but no difference in physical composite score (39.2 vs 43.8, p=0.06). SF-12 mental composite score was also a significant predictive variable when added to our expert model (p=0.01). Conclusions Preoperative patient reported mental health was independently associated with high grade complications after radical cystectomy. Therefore, patient self-assessment of health status before surgery through validated questionnaires may provide additional information useful in predicting short

  9. NAGC Pre-K-Grade 12 Gifted Education Programming Standards: A Guide to Planning and Implementing High-Quality Services

    ERIC Educational Resources Information Center

    Johnsen, Susan K., Ed.

    2012-01-01

    The new Pre-K-Grade 12 Gifted Education Programming Standards should be part of every school district's repertoire of standards to ensure that the learning needs of advanced students are being met. "NAGC Pre-K-Grade 12 Gifted Education Programming Standards: A Guide to Planning and Implementing High-Quality Services" details six standards that…

  10. Successful Transition to High School: A Randomized Controlled Trial of the Barr Model with 9th Grade Students

    ERIC Educational Resources Information Center

    Corsello, Maryann; Sharma, Anu; Jerabek, Angela

    2015-01-01

    Ninth grade is a pivotal year for students. Numerous studies find that academic performance in 9th grade often sets the student's trajectory throughout the high school years, as well as the probability of graduation. The Building Assets Reducing Risks (BARR) model is a comprehensive approach that addresses developmental, academic, and school…

  11. High Interest - Low Vocabulary Science Books, Reading Level Grades 1-4 (Prepared for the Remedial Reading Teacher).

    ERIC Educational Resources Information Center

    Gott, Margaret E., Comp.; Wailes, James R., Comp.

    This booklist is intended for elementary school science students with high interest and low vocabulary skills. The Spache Readability Scale, Dale-Chall formula, sentence structure, paragraph flow, illustration, and diagram analysis or publishers stated grade level were used to determine grade level designations. The included interest level varies…

  12. Gender Differences in Attitudes toward Mathematics between Low-Achieving and High-Achieving Fifth Grade Elementary Students.

    ERIC Educational Resources Information Center

    Rathbone, A. Sue

    Possible gender differences in attitudes toward mathematics were studied between low-achieving and high-achieving fifth-grade students in selected elementary schools within a large, metropolitan area. The attitudes of pre-adolescent children at an intermediate grade level were assessed to determine the effects of rapidly emerging gender-related…

  13. Functionally strain-graded nanoscoops for high power Li-ion battery anodes.

    PubMed

    Krishnan, Rahul; Lu, Toh-Ming; Koratkar, Nikhil

    2011-02-01

    Lithium-ion batteries show poor performance for high power applications involving ultrafast charging/discharging rates. Here we report a functionally strain-graded carbon-aluminum-silicon anode architecture that overcomes this drawback. It consists of an array of nanostructures each comprising an amorphous carbon nanorod with an intermediate layer of aluminum that is finally capped by a silicon nanoscoop on the very top. The gradation in strain arises from graded levels of volumetric expansion in these three materials on alloying with lithium. The introduction of aluminum as an intermediate layer enables the gradual transition of strain from carbon to silicon, thereby minimizing the mismatch at interfaces between differentially strained materials and enabling stable operation of the electrode under high-rate charge/discharge conditions. At an accelerated current density of ∼51.2 A/g (i.e., charge/discharge rate of ∼40C), the strain-graded carbon-aluminum-silicon nanoscoop anode provides average capacities of ∼412 mAh/g with a power output of ∼100 kW/kg(electrode) continuously over 100 charge/discharge cycles. PMID:21192713

  14. Characterization of High Ge Content SiGe Heterostructures and Graded Alloy Layers Using Spectroscopic Ellipsometry

    NASA Technical Reports Server (NTRS)

    Heyd, A. R.; Alterovitz, S. A.; Croke, E. T.

    1995-01-01

    Si(x)Ge(1-x)heterostructures on Si substrates have been widely studied due to the maturity of Si technology. However, work on Si(x)Ge)1-x) heterostructures on Ge substrates has not received much attention. A Si(x)Ge(1-x) layer on a Si substrate is under compressive strain while Si(x)Ge(1-x) on Ge is under tensile strain; thus the critical points will behave differently. In order to accurately characterize high Ge content Si(x)Ge(1-x) layers the energy shift algorithm used to calculate alloy compositions, has been modified. These results have been used along with variable angle spectroscopic ellipsometry (VASE) measurements to characterize Si(x)Ge(1-x)/Ge superlattices grown on Ge substrates. The results agree closely with high resolution x-ray diffraction measurements made on the same samples. The modified energy shift algorithm also allows the VASE analysis to be upgraded in order to characterize linearly graded layers. In this work VASE has been used to characterize graded Si(x)Ge(1-x) layers in terms of the total thickness, and the start and end alloy composition. Results are presented for a 1 micrometer Si(x)Ge(1-x) layer linearly graded in the range 0.5 less than or equal to x less than or equal to 1.0.

  15. Relationship between high- and low-grade Archean terranes: Implications for early Earth paleogeography

    NASA Technical Reports Server (NTRS)

    Eriksson, K. A.

    1986-01-01

    The Western Gneiss Terrain (WGT) of the Yilgarn Block, Western Australia was studied. The WGT forms an arcuate belt of Archean gneisses that flank the western margin of the Yilgarn Block. In general the WGT is composed of high-grade orthogneisses and paragneisses which contain supracrustal belts composed largely of siliciclastic metasediments and subordinate iron formation. The platformal nature of the metasedimentary belts and lack of obvious metavolcanic lithologies contrasts with the composition of typical Yilgarn greenstones to the east. Radiometric data from WGT rocks indicates that these rocks are significantly older than Yilgarn rocks to the east (less than 3.3 Ga) and this has led to the suggestion that the WGT represents sialic basement to Yilgarn granite-greenstone belts. The Mount Narryer region exposes the northernmost occurrence of high-grade metasediments within the WGT and consists of quartz-rich clastic metasediments at upper amphibolite to granulite grade. Most occurrences of supracrustal rocks in this region comprise isolated lenses within the gneissic basement. However, at Mount Narryer a unique sequence of metaclastics with preserved bedding provide an unusual window into the parentage of similar supracrustal bodies in this region.

  16. Fatigue of Austempered Ductile Iron with Two Strength Grades in Very High Cycle Regime

    NASA Astrophysics Data System (ADS)

    Zhang, Jiwang; Li, Wei; Song, Qingpeng; Zhang, Ning; Lu, Liantao

    2016-03-01

    In this study, Austempered ductile irons (ADIs) with two different strength grades were produced and the fatigue properties were measured at 109 cycles. The results show that the S-N curves give a typical step-wise shape and there is no fatigue limit in the very high cycle fatigue regime. The two grades ADI have the similar fracture behaviors and fatigue failure can initiate from defects at specimen surface and subsurface zone. On the fracture surfaces of some specimens, the `granular-bright-facet' area with rich carbon distribution is observed in the vicinity of the defect. The microstructure affects the crack behaviors at the early propagation stage. The ADI with upper and lower bainite shows higher fatigue strength compared with the ADI with coarse upper bainite.

  17. High-grade glioma management and response assessment—recent advances and current challenges

    PubMed Central

    Khan, M.N.; Sharma, A.M.; Pitz, M.; Loewen, S.K.; Quon, H.; Poulin, A.; Essig, M.

    2016-01-01

    The management of high-grade gliomas (hggs) is complex and ever-evolving. The standard of care for the treatment of hggs consists of surgery, chemotherapy, and radiotherapy. However, treatment options are influenced by multiple factors such as patient age and performance status, extent of tumour resection, biomarker profile, and tumour histology and grade. Follow-up cranial magnetic resonance imaging (mri) to differentiate treatment response from treatment effect can be challenging and affects clinical decision-making. An assortment of advanced radiologic techniques—including perfusion imaging with dynamic susceptibility contrast mri, dynamic contrast-enhanced mri, diffusion-weighted imaging, proton spectroscopy, mri subtraction imaging, and amino acid radiotracer imaging—can now incorporate novel physiologic data, providing new methods to help characterize tumour progression, pseudoprogression, and pseudoresponse. In the present review, we provide an overview of current treatment options for hgg and summarize recent advances and challenges in imaging technology. PMID:27536188

  18. Performance improvement of a high-temperature superconducting coil by separating and grading the coil edge

    NASA Astrophysics Data System (ADS)

    Ishiguri, Shinichi; Funamoto, Taisuke

    2011-06-01

    In this paper, we establish a model to analyze the transport current performance of a high-temperature superconducting (HTS) coil, considering the dependencies of critical current and n-value of an HTS tape on magnetic field and magnetic field angles. This analysis shows that relatively large electric fields appear at the coil’s edges, preventing improvement in the transport current performance of the coil. To solve this problem, in this paper, we propose a graded coil in which several coil edges of different heights are separated and graded. Analysis of its performance shows that the coil’s critical current increases, thus confirming that there exists an optimum coil cross section at which the stored energy and central magnetic field improve 2.1 times and 45%, respectively, compared with a typical rectangular coil that employs the same total length of the HTS tape. It is recommended that these results of the coil should be applied to SMES.

  19. The eastern limit of Acadian high grade metamorphism in northern New England: Implications for the location of the Acadian Suture''

    SciTech Connect

    West, D.P. Jr. . Dept. of Geological Sciences)

    1993-03-01

    Identifying the eastern limit of Acadian high grade metamorphism in New England is complicated by the presence of pre-Devonian high grade relics, locally intense Late Paleozoic thermal overprints, and post-metamorphic faults. New [sup 40]Ar/[sup 39]Ar mineral ages from along the eastern margin of high grade metamorphism in Maine and New Hampshire help delineate the eastern limit of Devonian amphibolite facies metamorphism thereby placing constraints on the location of the Acadian suture. In New Hampshire, Acadian high grade metamorphism extends southeast at least as far as the Campbell Hill fault and perhaps as far as the Flint Hill fault. New [sup 40]Ar/[sup 39]Ar hornblende ages and previously published U-Pb monazite ages from the Massabesic Gneiss Complex are Permian indicating high grade Alleghanian metamorphism. New [sup 40]Ar/[sup 39]Ar hornblende ages from the Rye Formation, although complicated by excess argon, are considerably older, indicating an earlier Pre-Silurian amphibolite facies metamorphism affected these rocks. North of Portland, [sup 40]Ar/[sup 39]Ar hornblende ages east of the Norumbega Fault Zone from high grade rocks of the Casco Bay Group have ages that range from Middle Devonian to Early Carboniferous, consistent with diachronous cooling following Acadian metamorphism. Further northeast, in upper amphibolite facies rocks of the Passagassawakeag Gneiss, new [sup 40]Ar/[sup 39]Ar hornblende ages range from 385--395 Ma suggesting that these rocks were also affected by high grade Acadian metamorphism.

  20. Presence of High-Risk Human Papillomavirus Genotype and Human Immunodeficiency Virus DNA in Anal High-Grade and Low-Grade Squamous Intraepithelial Lesions

    PubMed Central

    Liang, Chin-Yuan; Agsalda-Garcia, Melissa; Nagata, Ian; Milne, Cris; Zhu, Xuemei; Killeen, Jeffrey; Berry, J. Michael; Goodman, Marc T.

    2013-01-01

    Abstract Human immunodeficiency virus type 1 (HIV)-infected individuals are at risk for anal cancer, which is caused by human papillomavirus (HPV). The relationship between HIV and HPV that leads to anal cancer remains unclear. Recent data, however, suggest that the continued persistence of HIV DNA in patients treated with combined antiretroviral therapy leads to progression of HIV disease and other HIV-associated complications. Therefore, we investigated the relationship among anal low- and high-grade squamous intraepithelial lesions (LGSIL/HGSIL), high-risk HPV genotypes, and high HIV DNA copy numbers. Anal cytology specimens were assayed for HPV genotype and HIV DNA copy number. High-risk HPV genotypes (odds ratio OR: 3.73; 95% confidence interval CI: 1.08–12.91; p=0.04) and high HIV DNA copy numbers (ORper 100 HIV DNA copies: 1.13; 95% CI: 1.01–1.27, p=0.04) were both associated with LGSIL/HGSIL. When considering both high-risk HPV genotypes and HIV DNA copy numbers in predicting LGSIL/HGSIL, HIV DNA copy number was significant (ORper 100 HIV DNA copies: 1.09; 95% CI: 0.96–1.23, p=0.04) but not high-risk HPV genotypes (OR: 2.30, p=0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis. PMID:22816619

  1. Mixed low- and high-grade papillary urothelial carcinoma: histopathogenetic and clinical significance.

    PubMed

    Mai, Kien T; Flood, Trevor A; Williams, Phillip; Kos, Zuzana; Belanger, Eric C

    2013-10-01

    There are two pathways of urothelial carcinogenesis: low-grade urothelial carcinoma (LGUC) with low rates of gene alterations and high-grade urothelial carcinoma (HGUC) with numerous gene alterations. HGUC often displays strong reactivity for cytokeratin 20 (CK20) and p16. Despite distinct molecular changes, urothelial carcinoma (UC) with both low- and high-grade features is not uncommon. We examined cases with patterns of mixed low- and high-grade UC (MLHGUC). Consecutive cases of UC at our institution were reviewed. There were 45 cases that showed a mixture of both LGUC and HGUC. IHC for CK5, CK20, CD44, p16, and Ki67 was performed. Areas of HGUC displayed strong and diffuse reactivity for p16, CK20, and Ki67 in 20-50 % of the tumor, while LGUC areas had negative or focal reactivity for CK20 and Ki67 in 10-30 %. There were two distinct cohorts of MLHGUC: patients with a history of LGUC (group A) and those without (group B). Group A patients (n = 8) had a history of LGUC for 1-10 years. The tumor specimens weighed 1.5 ± 1.7 g and had HGUC components of 25 ± 20 % of the tissue. Superficial invasion was present in one case. All tumors had BCG treatment with one recurrence. In group B (n = 37), tumor specimens weighed 3 ± 3.9 g and had HGUC components in 43 ± 21 % of the tissue. Superficial invasion was present in five cases, and muscle invasion with lung metastasis occurred in one case. Four cases were refractory to BCG with an increased proportion of HGUC, and one case requiring cystectomy. Differences in size and proportion of HGUC between groups A and B MLHGUC were significant (P < 0.05), with group B presenting with a higher tumor burden and proportion of HGUC. MLHGUC is diagnostically challenging and is commonly assigned high grade since this determines prognosis. Group A MLHGUC likely develops as a result of progression from LGUC, whereas group B MLHGUC likely develops de novo, is associated with larger tumors, shows a

  2. High-grade renal injuries are often isolated in sports-related trauma

    PubMed Central

    Patel, Darshan P.; Redshaw, Jeffrey D.; Breyer, Benjamin N.; Smith, Thomas G.; Erickson, Bradley A.; Majercik, Sarah D.; Gaither, Thomas W.; Craig, James R.; Gardner, Scott; Presson, Angela P.; Zhang, Chong; Hotaling, James M.; Brant, William O.; Myers, Jeremy B.

    2016-01-01

    Introduction Most high-grade renal injuries (American Association for Surgery of Trauma (AAST) grades III–V) result from motor vehicle collisions associated with numerous concomitant injuries. Sports-related blunt renal injury tends to have a different mechanism, a solitary blow to the flank. We hypothesized that high-grade renal injury is often isolated in sports-related renal trauma. Material and methods We identified patients with AAST grades III–V blunt renal injuries from four level 1 trauma centres across the United States between 1/2005 and 1/2014. Patients were divided into “Sport” or “Non-sport” related groups. Outcomes included rates of hypotension (systolic blood pressure <90 mm Hg), tachycardia (>110 bpm), concomitant abdominal injury, and procedural/surgical intervention between sports and non-sports related injury. Results 320 patients met study criteria. 18% (59) were sports-related injuries with the most common mechanisms being skiing, snowboarding and contact sports (25%, 25%, and 24%, respectively). Median age was 24 years for sports and 30 years for non-sports related renal injuries (p = 0.049). Males were more commonly involved in sports related injuries (85% vs. 72%, p = 0.011). Median injury severity score was lower for sports related injuries (10 vs. 27, p < 0.001). There was no difference in renal abbreviated injury scale scores. Sports related trauma was more likely to be isolated without other significant injury (69% vs. 39% (p < 0.001)). Haemodynamic instability was present in 40% and 51% of sports and non-sports renal injuries (p = 0.30). Sports injuries had lower transfusion (7% vs. 47%, p < 0.001) and lower mortality rates (0% vs. 6%, p = 0.004). There was no difference in renal-specific procedural interventions between the two groups (17% sports vs. 18% non-sports, p = 0.95). Conclusions High-grade sports-related blunt renal trauma is more likely to occur in isolation without other abdominal or thoracic injuries and

  3. High velocity continuous-flow reactor for the production of solar grade silicon

    NASA Technical Reports Server (NTRS)

    Woerner, L.

    1977-01-01

    The feasibility of a high volume, high velocity continuous reduction reactor as an economical means of producing solar grade silicon was tested. Bromosilanes and hydrogen were used as the feedstocks for the reactor along with preheated silicon particles which function both as nucleation and deposition sites. A complete reactor system was designed and fabricated. Initial preheating studies have shown the stability of tetrabromosilane to being heated as well as the ability to preheat hydrogen to the desired temperature range. Several test runs were made and some silicon was obtained from runs carried out at temperatures in excess of 1180 K.

  4. Grading More Accurately

    ERIC Educational Resources Information Center

    Rom, Mark Carl

    2011-01-01

    Grades matter. College grading systems, however, are often ad hoc and prone to mistakes. This essay focuses on one factor that contributes to high-quality grading systems: grading accuracy (or "efficiency"). I proceed in several steps. First, I discuss the elements of "efficient" (i.e., accurate) grading. Next, I present analytical results…

  5. Well Differentiated Neuroendocrine Tumors with a Morphologically Apparent High Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas

    PubMed Central

    Tang, Laura H.; Untch, Brian R.; Reidy, Diane L.; O'Reilly, Eileen; Dhall, Deepti; Jih, Lily; Basturk, Olca; Allen, Peter J.; Klimstra, David S.

    2016-01-01

    Purpose Most well-differentiated neuroendocrine tumors (WD-NETs) of the enteropancreatic system are low-intermediate grade (G1,G2). Elevated proliferation demonstrated by either a brisk mitotic rate (>20/10 high power fields) or high Ki67 index (>20%) defines a group of aggressive neoplasms designated as high grade (G3) neuroendocrine carcinoma (NEC). High grade NEC is equated with poorly-differentiated NEC (PD-NEC) and is associated with a dismal outcome. Progression of WD-NETs to a high grade neuroendocrine neoplasm very rarely occurs and their clinicopathologic and molecular features need to be characterized. Methods We investigated the 31 cases of WD-NETs with evidence of component of a high grade neoplasm. The primary sites included pancreas, small bowel, bile duct, and rectum. Histopathology of the cases was retrospectively reviewed and selected immunohistochemistry and gene mutation analyses performed. Results The high grade component occurred either within the primary tumor (48%) or at metastatic sites (52%). The clinical presentation, radiographic features, biomarkers, and the genotype of these WD-NETs with high grade component remained akin to those of G1-G2 WD-NETs. The median disease specific survival (DSS) was 55 months (16-119 months), and 2-year and 5-year DSS was 88% and 49%, respectively – significantly better than that of a comparison group of true PD-NEC (DSS 11 months). Conclusion Mixed grades can occur in WD-NETs, which are distinguished from PDNECs by their unique phenotype, proliferative indices, and the genotype. This phenomenon of mixed grade in WD-NET provides additional evidence to the growing recognition that the current WHO G3 category contains both WD-NETs as well as PDNECs. PMID:26482044

  6. Employment during High School: Consequences for Students? Grades in Academic Courses.

    ERIC Educational Resources Information Center

    Warren, John Robert; LePore, Paul C.; Mare, Robert D.

    2000-01-01

    Studied the effects of adolescent employment on grades in academic courses and the extent to which grades might influence employment behaviors using data from the National Education Longitudinal Study of 1988. Findings contained no evidence of short-term or long-term effects on grades, or that grades affect employment activities. Pre-existing…

  7. Number Sense-Based Strategies Used by High-Achieving Sixth Grade Students Who Experienced Reform Textbooks

    ERIC Educational Resources Information Center

    Alsawaie, Othman N.

    2012-01-01

    The purpose of this study was to explore strategies used by high-achieving 6th grade students in the United Arab Emirates (UAE) to solve basic arithmetic problems involving number sense. The sample for the study consisted of 15 high-achieving boys and 15 high-achieving girls in grade 6 from 2 schools in the Emirate of Abu Dhabi, UAE. Data for the…

  8. "High-grade burial metamorphism of sedimentary mélange, Shoo Fly Complex, central Sierra Nevada, California"

    NASA Astrophysics Data System (ADS)

    Mendoza, Y.; Wakabayashi, J.

    2013-12-01

    The Shoo Fly Complex, California is a subduction complex metamorphosed at lower greenschist facies in much of the northern Sierra Nevada. Central Sierra Nevada exposures include higher grade assemblages. Previous studies have interpreted the higher grade rocks as gneissic granitoids representing the roots of a Paleozoic arc. Recent field work in the North Fork Mokelumne River drainage, shows that high-grade and low-grade metamorphic rocks were derived from similar subduction complex protoliths. The Shoo Fly in this region consists of mostly phyllite (metasiltstone, metasandstone, metachert), with some metabasite, and metaultramafic blocks. There is a metamorphic gradient from west to east in the field area, transitioning from sub to lower greenschist facies (white mica only) to middle and upper green schist facies (biotite) within the phyllites to amphibolite/upper amphibolite/granulite grade mica schists, gneisses, and amphibolites This gradient occurs across a zone about 1.5 km wide and this gradient is about 5 km west of the contact between the Shoo Fly Complex and plutons of the Sierra Nevada batholith. The higher-grade rocks do not have an apparent west-east metamorphic gradient. Accordingly the high-grade metamorphism does not appear to be a consequence of either contact metamorphism or raised regional geothermal gradients connected with the batholith. This conclusion is consistent with the fact that published metamorphic ages from probable correlative rocks within the central Sierra are much older than the Sierra Nevada batholith. Protoliths for the higher grade rocks appear identical to the lower grade rocks, for metaclastic rocks dominate with subordinate metacherts, metabasites, and metaultramafic rocks. The latter are represented by tremolite-talc schists. In the lower grade rocks some of the metabasite and metaultramafic blocks exhibit a higher grade of metamorphism than the surrounding metaclastic rocks and metacherts. Amphibolite and tremolite schist

  9. EDITORIAL: Selected papers from the 11th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2011) Selected papers from the 11th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2011)

    NASA Astrophysics Data System (ADS)

    Cho, Young-Ho

    2012-09-01

    This special section of Journal of Micromechanics and Microengineering features papers selected from the 11th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2011), held at Sejong Hotel in Seoul, Korea during 15-18 November 2011. Since the first PowerMEMS workshop held in Sendai, Japan in 2000, the workshop has developed as the premier forum for reporting research results in micro and nanotechnology for power generation, energy conversion, harvesting and processing applications, including in-depth technical issues on nanostructures and materials for small-scale high-density energy and thermal management. Potential PowerMEMS applications cover not only portable power devices for consumer electronics and remote sensors, but also micro engines, impulsive thrusters and fuel cells for systems ranging from the nanometer to the millimeter scale. The 2011 technical program consists of 1 plenary talk, 4 invited talks and 118 contributed presentations. The 48 oral and 70 poster presentations, selected by 27 Technical Program Committee Members from 131 submitted abstracts, have stimulated lively discussion maximizing the interaction between participants. Among them, this special section includes 9 papers covering micro-scale power generators, energy converters, harvesters, thrusters and thermal coolers. Finally, we are grateful to the members of the International Steering Committee, the Technical Program Committee, and the Local Organizing Committee for their efforts and contributions to PowerMEMS 2011. We also thank the two companies Samsung Electro-Mechanics and LG Elite for technical tour arrangements. Special thanks go to Dr Ian Forbes, the editorial staff of the Journal of Micromechanics and Microengineering, as well as to the staff of IOP Publishing for making this special section possible.

  10. Downregulation of microRNA-504 is associated with poor prognosis in high-grade glioma

    PubMed Central

    Guan, Yanlei; Chen, Ling; Bao, Yijun; Pang, Chao; Cui, Run; Li, Guangyu; Liu, Jiyuan; Wang, Yunjie

    2015-01-01

    Several previous reports indicated that microRNA-504 (miR-504) has an oncogenic function through negatively regulating p53. On the other hand, a recent study revealed that miR-504 inhibits cancer cell proliferation through targeting CDK6 in hypopharyngeal squamous cell carcinoma (HSCC), suggesting the tumor suppressive role of this miRNA. However, the role of miR-504 in human malignant glioma remains unclear. Therefore, the aim of this study was to investigate the clinical significance of miR-504 expression in high pathological grade glioma. Quantitative real-time reverse transcriptive-PCR (qRT-PCR) was performed to examine miR-504 expression levels in 63 glioma tissues including 13 anaplastic astrocytomas (AA, WHO grade III) and 50 glioblastomas (GBM, WHO grade IV), as well as 10 non-neoplastic brain tissues. Associations between miR-504 expression and clinicopathological factors and prognosis of glioma patients were statistically analyzed. MiR-504 showed significant decreased expression levels both in AAs and GBMs relative to non-neoplastic brains (P ≤ 0.001, respectively). Additionally, low expression level of miR-504 was significantly associated with advanced WHO grade (P = 0.01). Moreover, Kaplan-Meier survival analysis showed that patients with low expression of miR-504 had significantly poor survival rate (P = 0.002). Cox regression analysis showed that miR-504 expression was independent prognosis-predicting factor for malignant glioma patients (P = 0.038; risk ration = 2.5). Our results suggest that miR-504 may be a prognostic predictor and be involved in tumorigencity as a tumor suppressor of malignant glioma. PMID:25755767

  11. Advances in Tumor Screening, Imaging, and Avatar Technologies for High-Grade Serous Ovarian Cancer

    PubMed Central

    Ohman, Anders W.; Hasan, Noor; Dinulescu, Daniela M.

    2014-01-01

    The majority of high-grade serous ovarian carcinoma cases are detected in advanced stages when treatment options are limited. Surgery is less effective at eradicating the disease when it is widespread, resulting in high rates of disease relapse and chemoresistance. Current screening techniques are ineffective for early tumor detection and consequently, BRCA mutations carriers, with an increased risk for developing high-grade serous ovarian cancer, elect to undergo risk-reducing surgery. While prophylactic surgery is associated with a significant reduction in the risk of cancer development, it also results in surgical menopause and significant adverse side effects. The development of efficient early-stage screening protocols and imaging technologies is critical to improving the outcome and quality of life for current patients and women at increased risk. In addition, more accurate animal models are necessary in order to provide relevant in vivo testing systems and advance our understanding of the disease origin and progression. Moreover, both genetically engineered and tumor xenograft animal models enable the preclinical testing of novel imaging techniques and molecularly targeted therapies as they become available. Recent advances in xenograft technologies have made possible the creation of avatar mice, personalized tumorgrafts, which can be used as therapy testing surrogates for individual patients prior to or during treatment. High-grade serous ovarian cancer may be an ideal candidate for use with avatar models based on key characteristics of the tumorgraft platform. This review explores multiple strategies, including novel imaging and screening technologies in both patients and animal models, aimed at detecting cancer in the early-stages and improving the disease prognosis. PMID:25478323

  12. Proliferative activity (ki-67 expression) and outcome in high grade osteosarcoma: a study of 27 cases.

    PubMed

    Jong, R; Davis, A M; Mendes, M G; Wunder, J S; Bell, R S; Kandel, R

    2000-01-01

    Purpose. Although pre-operative chemotherapy has improved the prognosis for individuals with osteosarcoma, approximately 40% of patients will die of their disease.The aim of this study was to quantitate proliferative activity in high grade osteosarcomas and to determine whether proliferation is a prognostic factor.Patients. The study consisted of 27 patients with high grade non-metastatic osteosarcoma at various sites for whom pre-operative biopsies and resection specimens were available for review. All patients were treated similarly and had at least 24 months' follow-up from the date of diagnosis.Methods. Proliferative activity (Ki-67 expression) was examined in the diagnostic biopsies immunohistochemically using the MIB-1 antibody. Proliferation was quantitated in two ways; (1) the number of immunopositive cells was counted manually using an ocular grid; or (2) the percentage of immunopositive nuclear area was assessed using morphometric image analysis. Proliferative index was evaluated in relation to patient outcome.Results. Proliferative activity was seen in all biopsies.The median proliferative index as determined by counting cells was 24% (mean of 27%, range of 7-61%) and by image analysis was 2% (mean 3%, range 0.32-8.4).The correlation between MIB-1 proliferation indices determined either by image analysis methodology or manual cell counting was high (Spearman's rho=0.79). Proliferative index did not appear to predict either disease-free or overall survival.Discussion. Tumor proliferation does not appear to be prognostic for high grade osteosarcomas.Whether assessment of this feature in conjunction with other tumor characteristics might be prognostic requires further study. PMID:18521434

  13. High temperature deformation behavior, thermal stability and irradiation performance in Grade 92 steel

    NASA Astrophysics Data System (ADS)

    Alsagabi, Sultan

    The 9Cr-2W ferritic-martensitic steel (i.e. Grade 92 steel) possesses excellent mechanical and thermophysical properties; therefore, it has been considered to suit more challenging applications where high temperature strength and creep-rupture properties are required. The high temperature deformation mechanism was investigated through a set of tensile testing at elevated temperatures. Hence, the threshold stress concept was applied to elucidate the operating high temperature deformation mechanism. It was identified as the high temperature climb of edge dislocations due to the particle-dislocation interactions and the appropriate constitutive equation was developed. In addition, the microstructural evolution at room and elevated temperatures was investigated. For instance, the microstructural evolution under loading was more pronounced and carbide precipitation showed more coarsening tendency. The growth of these carbide precipitates, by removing W and Mo from matrix, significantly deteriorates the solid solution strengthening. The MX type carbonitrides exhibited better coarsening resistance. To better understand the thermal microstructural stability, long tempering schedules up to 1000 hours was conducted at 560, 660 and 760°C after normalizing the steel. Still, the coarsening rate of M23C 6 carbides was higher than the MX-type particles. Moreover, the Laves phase particles were detected after tempering the steel for long periods before they dissolve back into the matrix at high temperature (i.e. 720°C). The influence of the tempering temperature and time was studied for Grade 92 steel via Hollomon-Jaffe parameter. Finally, the irradiation performance of Grade 92 steel was evaluated to examine the feasibility of its eventual reactor use. To that end, Grade 92 steel was irradiated with iron (Fe2+) ions to 10, 50 and 100 dpa at 30 and 500°C. Overall, the irradiated samples showed some irradiation-induced hardening which was more noticeable at 30°C. Additionally

  14. Petrology and Geochronology of High-Grade Metamorphic Rocks from Cedros Island, Baja California, Mexico

    NASA Astrophysics Data System (ADS)

    Gonzales, D.; Leech, M. L.

    2014-12-01

    High-grade metamorphic rocks exposed on Cedros Island, Baja California, Mexico, record the Mesozoic subduction history of western North America. Blocks of amphibolite, blueschist, and eclogite crop out in a serpentinite-matrix mélange on the southeast and southwestern parts of Cedros Island. Amphibolite blocks contain Amp + Ep + Ab + Chl ± Ms ± Grt ± Ttn ± Qz; blueschist blocks have the assemblage Na-Amp + Ms + Lw + Qz ± Ttn ± Grt ± Jd ± Chl; and eclogite blocks are comprised primarily of Omp + Grt with retrograde Na-Amp + Ms + Lw. Blueschists from Cedros have been dated using 40Ar/39Ar step-heating of white mica and sodic amphiboles that yield ages from 103 ± 4 Ma to 94.9 ± 1.1 Ma, respectively, that represent cooling during exhumation. Apatite fission-track dating gives ages from 32 ± 4 Ma to 22 ± 3 Ma that record exhumation through the upper crust. Related Mesozoic subduction zone rocks of the Franciscan Complex crop out in a serpentinite-matrix mélange along coastal northern California. The Franciscan rocks are older, yielding 40Ar/39Ar step-heating ages of hornblende from amphibolite ranging from 159 to 156 Ma and represent an older part of the subduction history of the oceanic Farallon plate along western North America. I will determine the prograde and peak metamorphic P-T conditions for these high-grade rocks using petrography, mineral chemistries, and isochemical phase diagram modeling with Perple_X to generate complete P-T paths. I will then supplement these data with Sm-Nd and Lu-Hf geochronology for these high-grade Cedros rocks to evaluate their subduction/exhumation history, and develop a tectonic model for these southernmost Franciscan-type rocks. Ultimately, I will compare my results to Franciscan rocks in northern California to better understand the Mesozoic subduction margin of western North America.

  15. Role of Combined Circumareolar Skin Excision and Liposuction in Management of High grade Gynaecomastia

    PubMed Central

    Sarkar, Arindam; Bain, Jayanta; Bhattacharya, Debtanu; Sawarappa, Raghavendra; Munian, Kinkar; Dutta, Gouranga; Naiyer, Ghulam Jeelani; Ahmad, Shamshad

    2014-01-01

    Introduction: High-grade gynaecomastia (Simon IIb and III) has tissue excess (skin excess, enlarged areola, and displaced nipple), which is best managed surgically; however, results of conventional breast reduction surgeries and liposuction is not very good. Aim of our study was to describe a combined technique to manage these problems to produce a good result. Material and Method: This was a 2-year study among 12 patients of high grade gynaecomastia. Clinical and laboratory findings were normal. Pre-operatively in standing position, diameter of breast and areola, position of nipple, and amount of skin excess were marked. Under general anaesthesia, tumescent infiltration, circumareolar de-epithelisation of skin excess, and liposuction was completed. Redundant portion of the breast was sharply dissected and pulled out. Areola was fixed over pectoralis fascia at mid humerus level, just medial to the mid-clavicular line. Outer borders of the de-epithelised area were apposed by the purse-string effect of a subdermal suture, and further apposed by few half buried horizontal mattress sutures. Drains for 24 hour and compressive dressings for 6 weeks were used. Result: Mean age of presentation was 25.8 year; emotional discomfort was the chief complaint. Among 12 patients, 10 patients had bilateral gynaecomastia and 8 patients had enlarged and displaced nipple-areola complex. Average hospital stay was 2.41 days and recoveries were usually uneventful. Conclusion: The problem of tissue excess and tissue displacement in high grade gynaecomastia can be well managed by this combined circumareolar skin reduction and liposuction technique to achieve a scar-less flat male chest. PMID:25136214

  16. Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

    PubMed Central

    2013-01-01

    Background High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue sarcomas have increasingly been classified on the basis of underlying genetic alterations; however, the role of aberrant DNA methylation in these tumors is not well understood and, consequently, the usefulness of methylation-based classification is unclear. Results We used the Infinium HumanMethylation27 platform to profile DNA methylation in 80 primary, untreated high-grade soft tissue sarcomas, representing eight relevant subtypes, two non-neoplastic fat samples and 14 representative sarcoma cell lines. The primary samples were partitioned into seven stable clusters. A classification algorithm identified 216 CpG sites, mapping to 246 genes, showing different degrees of DNA methylation between these seven groups. The differences between the clusters were best represented by a set of eight CpG sites located in the genes SPEG, NNAT, FBLN2, PYROXD2, ZNF217, COL14A1, DMRT2 and CDKN2A. By integrating DNA methylation and mRNA expression data, we identified 27 genes showing negative and three genes showing positive correlation. Compared with non-neoplastic fat, NNAT showed DNA hypomethylation and inverse gene expression in myxoid liposarcomas, and DNA hypermethylation and inverse gene expression in dedifferentiated and pleomorphic liposarcomas. Recovery of NNAT in a hypermethylated myxoid liposarcoma cell line decreased cell migration and viability. Conclusions Our analysis represents the first comprehensive integration of DNA methylation and transcriptional data in primary high-grade soft tissue sarcomas. We propose novel biomarkers and genes relevant for pathogenesis, including NNAT as a potential tumor suppressor in myxoid liposarcomas. PMID:24345474

  17. Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation.

    PubMed

    Thompson, Lester D; Aslam, Muhammad N; Stall, Jennifer N; Udager, Aaron M; Chiosea, Simion; McHugh, Jonathan B

    2016-06-01

    Acinic cell carcinoma (AiCC) with high-grade transformation is a rare variant of AiCC composed of both a conventional low-grade (LG) AiCC and a separate high-grade (HG) component. We describe here, the clinicopathologic and immunohistochemical features of 25 cases diagnosed between 1990 and 2015. Available tissue was analyzed and compared with a cohort of pure LG AiCC for the morphologic and immunophenotypic profile. Incidence was higher in females (1.8:1) than males with an overall mean age at presentation of 63.2 years. All tumors occurred in the parotid gland including 76 % with facial nerve trunk and branches involvement. Most patients were treated with extensive resection and adjuvant therapy. Local recurrence or distant metastasis occurred in most patients, with 72.7 % dead with disease (mean 2.9 years) and 3 patients alive with disease (mean 2.4 years). The majority of the tumors were composed of a LG microcystic AiCC and a HG component consisting of invasive lobules of undifferentiated cells with predominantly solid, cribriform, and glandular patterns. Acinic differentiation was still present in HG areas but aggressive features such as perineural invasion (76 %), lymphovascular invasion (62 %), positive margins (72 %), high mitotic rate, atypical mitoses and/or comedonecrosis (86 %) were easily identified. Compared to the pure LG AiCC, the cases with HG transformation showed significantly increased expression of cyclin-D1, p53 and Ki-67. Most HG areas of AiCC expressed membranous β-catenin (92 %) and were negative for p63 (three cases were focally positive), S100, SMA, androgen, and estrogen receptors. DOG1 expression was present in all LG AiCC tested with retained expression in 91 % of cases with HG transformation, supporting acinic differentiation in the HG foci. Recognition of AiCC with high-grade transformation is imperative as more aggressive clinical management is warranted. PMID:26245749

  18. Genomic profiling of high-grade large-cell neuroendocrine carcinoma of the colon

    PubMed Central

    Hammond, William A.; Crozier, Jennifer A.; Nakhleh, Raouf E.

    2016-01-01

    High-grade neuroendocrine carcinoma (HGNEC) of the colon is a rare and aggressive cancer that has a poor prognosis. Currently no standard treatment exists, and published case series report an overall survival of approximately one year with treatment. Typically patients receive treatment similar to that recommended for small-cell lung cancer, extrapolating from the similarity in cancer biology. Here we report a case of HGNEC of the colon with genomic profiling that identified a KRAS G12D mutation and a PI3K mutation that has not yet been reported in the literature for this tumor type. PMID:27034803

  19. Comprehensive Assessment and Classification of High-Grade B-cell Lymphomas.

    PubMed

    Behdad, Amir; Bailey, Nathanael G

    2016-03-01

    High-grade B-cell lymphomas (HGBCLs) are a heterogeneous group of neoplasms that include subsets of diffuse large B-cell lymphoma, Burkitt lymphoma, and lymphomas with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Morphologically indistinguishable HGBCLs may demonstrate variable clinical courses and responses to therapy. The morphologic evaluation and classification of these neoplasms must be followed by further genetic and immunophenotypic work-up. These additional diagnostic modalities lead to a comprehensive stratification of HGBCL that determines the prognosis and optimal therapy. This article reviews the well-established and emerging biomarkers that are most relevant to the clinical management of HGBCL. PMID:26940267

  20. Prostate cancer with a pseudocapsule at MR imaging: a marker of high grade and stage disease?

    PubMed

    Bonde, Apurva A; Korngold, Elena K; Foster, Bryan R; Westphalen, Antonio C; Pettersson, David R; Troxell, Megan L; Simko, Jeffry P; Coakley, Fergus V

    2016-01-01

    Clinicopathological correlates of prostate cancer associated with a pseudocapsule at T2-weighted magnetic resonance (MR) imaging are presented in a retrospective series of 15 patients. Of 15 tumors, 14 involved the peripheral zone. Extracapsular extension was seen in 14 cases. Tumor Gleason score was 8 or above in 12 of 15 cases, and ductal type adenocarcinoma was identified in 4 cases. Step section histopathological correlation (n=5) demonstrated that the pseudocapsule corresponded with dense compressive or reactive peritumoral fibrosis. A pseudocapsule around prostate cancer at T2-weighted MR imaging is a rare finding that appears to be associated with high grade and stage disease. PMID:27133669

  1. New generation of high average power industry grade ultrafast ytterbium fiber lasers

    NASA Astrophysics Data System (ADS)

    Yusim, Alex; Samartsev, Igor; Shkurikhin, Oleg; Myasnikov, Daniil; Bordenyuk, Andrey; Platonov, Nikolai; Kancharla, Vijay; Gapontsev, Valentin

    2016-03-01

    We report an industrial grade picosecond and femtosecond pulse Yb fiber lasers with >100 μJ pulse energy and hundreds of Watts of average power for improved laser machining speed of sapphire and glass. This highly efficient laser offers >25% wall plug efficiency within a compact 3U rack-mountable configuration plus a long >2m fiber delivery cable. Reconfigurable features such as controllable repetition rate, fine pulse duration control, burst mode operation and adjustable pulse energy permit the customer to tailor the laser to their application.

  2. Nonlinear ghost waves accelerate the progression of high-grade brain tumors

    NASA Astrophysics Data System (ADS)

    Pardo, Rosa; Martínez-González, Alicia; Pérez-García, Víctor M.

    2016-10-01

    We study a reduced continuous model describing the evolution of high grade gliomas in response to hypoxic events through the interplay of different cellular phenotypes. We show that hypoxic events, even when sporadic and/or limited in space, may have a crucial role on the acceleration of high grade gliomas growth. Our modeling approach is based on two cellular phenotypes. One of them is more migratory and a second one is more proliferative. Transitions between both phenotypes are driven by the local oxygen values, assumed in this simple model to be uniform. Surprisingly, even very localized in time hypoxia events leading to transient migratory populations have the potential to accelerate the tumor's invasion speed up to speeds close to those of the migratory phenotype. The high invasion speed persists for times much longer than the lifetime of the hypoxic event. Moreover, the phenomenon is observed both when the migratory cells form a persistent wave of cells located on the invasion front and when they form a evanescent "ghost" wave disappearing after a short time by decay to the more proliferative phenotype. Our findings are obtained through numerical simulations of the model equations both in 1D and higher dimensional scenarios. We also provide a deeper mathematical analysis of some aspects of the problem such as the conditions for the existence of persistent waves of cells with a more migratory phenotype.

  3. Structural patterns in high grade terrain in parts of Tamil Nadu and Karnataka

    NASA Technical Reports Server (NTRS)

    Sugavanam, E. B.; Vidyadharan, K. T.

    1988-01-01

    Detailed geological mapping in parts of Tamil Nadu and Karnataka has brought out vast areas occupied by highly deformed charnockite and high grade gneisses. These areas, similar to high grade shield terrains in other parts of the world have the impress of extensive tectonic reworking multideformation and polymetamorphism and are closely associated with layered ultramafics, shelf type sediments and different igneous events. In North Arcot and Charmapuri districts of Tamil Nadu and Kollegal taluk in Mysore district in Karnataka, charnockite is intensely cofolded with a supracrustal succession of layered ultramafics, pyroxene granulite, pink granolites, magnetite quartzite and khondalites. These areas have undergone five phases of deformation, five generations of basic dyke activities, four phases of migmatisation and two periods of metallogeny. Geochronological data ranges from 2900 m.y. to 750 m.y. In working out the tectanostratigraphy of the above areas the basic dykes of different generations have served as major time markers. In addition, the persistent strike continuity of linear bands of pyroxene granulite, pink granolite and magnetite quartzite has been of great utility in using them as structural markers for bringing out the complex structural history in these areas.

  4. High-grade sarcoma diagnosis and prognosis: Biomarker discovery by mass spectrometry imaging.

    PubMed

    Lou, Sha; Balluff, Benjamin; de Graaff, Marieke A; Cleven, Arjen H G; Briaire-de Bruijn, Inge; Bovée, Judith V M G; McDonnell, Liam A

    2016-06-01

    The combination of high heterogeneity, both intratumoral and intertumoral, with their rarity has made diagnosis, prognosis of high-grade sarcomas difficult. There is an urgent need for more objective molecular biomarkers, to differentiate between the many different subtypes, and to also provide new treatment targets. Mass spectrometry imaging (MSI) has amply demonstrated its ability to identify potential new markers for patient diagnosis, survival, metastasis and response to therapy in cancer research. In this study, we investigated the ability of MALDI-MSI of proteins to distinguish between high-grade osteosarcoma (OS), leiomyosarcoma (LMS), myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) (Ntotal = 53). We also investigated if there are individual proteins or protein signatures that are statistically associated with patient survival. Twenty diagnostic protein signals were found characteristic for specific tumors (p ≤ 0.05), amongst them acyl-CoA-binding protein (m/z 11 162), macrophage migration inhibitory factor (m/z 12 350), thioredoxin (m/z 11 608) and galectin-1 (m/z 14 633) were assigned. Another nine protein signals were found to be associated with overall survival (p ≤ 0.05), including proteasome activator complex subunit 1 (m/z 9753), indicative for non-OS patients with poor survival; and two histone H4 variants (m/z 11 314 and 11 355), indicative of poor survival for LMS patients. PMID:27174013

  5. Intensity-modulated radiotherapy in high-grade gliomas: Clinical and dosimetric results

    SciTech Connect

    Narayana, Ashwatha . E-mail: narayana@mskcc.org; Yamada, Josh; Berry, Sean; Shah, Priti B.S.; Hunt, Margie; Gutin, Philip H.; Leibel, Steven A.

    2006-03-01

    Purpose: To report preliminary clinical and dosimetric data from intensity-modulated radiotherapy (IMRT) for malignant gliomas. Methods and Materials: Fifty-eight consecutive high-grade gliomas were treated between January 2001 and December 2003 with dynamic multileaf collimator IMRT, planned with the inverse approach. A dose of 59.4-60 Gy at 1.8-2.0 Gy per fraction was delivered. A total of three to five noncoplanar beams were used to cover at least 95% of the target volume with the prescription isodose line. Glioblastoma accounted for 70% of the cases, and anaplastic oligodendroglioma histology (pure or mixed) was seen in 15% of the cases. Surgery consisted of biopsy only in 26% of the patients, and 80% received adjuvant chemotherapy. Results: With a median follow-up of 24 months, 85% of the patients have relapsed. The median progression-free survival time for anaplastic astrocytoma and glioblastoma histology was 5.6 and 2.5 months, respectively. The overall survival time for anaplastic glioma and glioblastoma was 36 and 9 months, respectively. Ninety-six percent of the recurrences were local. No Grade IV/V late neurologic toxicities were noted. A comparative dosimetric analysis revealed that regardless of tumor location, IMRT did not significantly improve target coverage compared with three-dimensional planning. However, IMRT resulted in a decreased maximum dose to the spinal cord, optic nerves, and eye by 16%, 7%, and 15%, respectively, owing to its improved dose conformality. The mean brainstem dose also decreased by 7%. Intensity-modulated radiotherapy delivered with a limited number of beams did not result in an increased dose to the normal brain. Conclusions: It is unlikely that IMRT will improve local control in high-grade gliomas without further dose escalation compared with conventional radiotherapy. However, it might result in decreased late toxicities associated with radiotherapy.

  6. Cognitive strategies and quality of life of patients with high-grade glioma.

    PubMed

    Lucchiari, C; Botturi, A; Silvani, A; Lamperti, E; Gaviani, P; Innocenti, A; Finocchiaro, C Y; Masiero, M; Pravettoni, G

    2015-12-01

    The purpose of this study was to analyze the psychological well-being, quality of life, and cognitive strategies activated by patients with high-grade glioma. We hypothesized that the self-perceived quality of life is modulated by physical and psychological factors and that in order to understand this modulation more psychometric approaches are necessary. Data were collected from a sample of 73 consecutive patients with a histological diagnosis of primary malignant brain cancer (grade IV glioblastoma and grade III anaplastic astrocytoma) hospitalized in a specialized Italian center. The Functional Assessment of Cancer Therapy (FACT) scale and the Schedule of Evaluation of Individual Quality of Life-Direct Weighting (SEIQoL-DW) scale were used to assess quality of life. The mean FACT-Brain (Br) score was 122.37. Similarly, the median SEIQoL-DW score was 72.9 out of a maximum value of 100. No gender effect was found in relation to overall quality of life. Patients with high depression and/or anxiety scores reported lower quality of life (QoL) scores in all the instruments considered. We did not find any gender effect concerning depression and anxiety levels. However, we found that men and women, though having similar physical and functional well-being, reported different QoL determinants, since men seem to rely more on physical adjustment, while women activate more introspective strategies. Positive actions, family issues, negative thoughts, health, and positive thoughts were found to be the most reported themes. In conclusion, the present study strongly suggests that a positive psychological adjustment is possible also in the event of a severe diagnosis and during aggressive treatments, but QoL determinants might be considered too in order to help health professionals to understand patients' experience and to meet their needs. PMID:25761757

  7. Analysis of EZH2: micro-RNA network in low and high grade astrocytic tumors.

    PubMed

    Sharma, Vikas; Purkait, Suvendu; Takkar, Sonam; Malgulwar, Prit Benny; Kumar, Anupam; Pathak, Pankaj; Suri, Vaishali; Sharma, Mehar C; Suri, Ashish; Kale, Shashank Sharad; Kulshreshtha, Ritu; Sarkar, Chitra

    2016-04-01

    Enhancer of Zeste homologue2 (EZH2) is an epigenetic regulator that functions as oncogene in astrocytic tumors, however, EZH2 regulation remains little studied. In this study, we measured EZH2 levels in low (Gr-II,DA) and high grade (Gr-IV,GBM) astrocytic tumors and found significant increased EZH2 transcript level with grade(median DA-8.5, GBM-28.9).However, a different trend was reflected in protein levels, with GBMs showing high EZH2 LI(median-26.5) compared to DA (median 0.3). This difference in correlation of EZH2 protein and RNA levels suggested post-transcriptional regulation of EZH2, likely mediated by miRNAs. We selected eleven miRNAs that strongly predicted to target EZH2 and measured their expression. Three miRNAs (miR-26a-5p,miR27a-3p and miR-498) showed significant correlation with EZH2 protein, suggesting them as regulators of EZH2, however miR-26a-5p levels decreased with grade. ChIP analyses revealed H3K27me3 modifications in miR-26a promoter suggesting feedback loop between EZH2 and miR26a. We further measured six downstream miRNA targets of EZH2 and found significant downregulation of four (miR-181a/b and 200b/c) in GBM. Interestingly, EZH2 associated miRNAs were predicted to target 25 genes in glioma-pathway, suggesting their role in tumor formation or progression. Collectively, our work suggests EZH2 and its miRNA interactors may serve as promising biomarkers for progression of astrocytic tumors and may offer novel therapeutic strategies. PMID:26746204

  8. Surveillance of Anaemia: Mapping and Grading the High Risk Territories and Populations

    PubMed Central

    Amirapu, Pallavi

    2016-01-01

    Introduction Surveillance of anaemia is an ongoing process for assessing iron status and anaemia prevalence among individuals and the communities they live in. Measuring blood haemoglobin levels is the commonest method espoused worldwide for screening individuals and populations for anaemia and iron deficiency. World Health Organization (WHO) proposed a classification of public health significance of anaemia in populations on the basis of prevalence estimated from blood levels of haemoglobin. India falls under “Severe public health problem” category. An attempt has been made to categorise “Severe public health problem” into grades of severity that will help in prioritising the states and districts for targeted action. Aim To adapt the “WHO Classification of anaemia as a problem of public health significance” and to use the same to identify and map high risk population groups in the southern states of India. Materials and Methods The category of ’Severe Public Health Problem’ has been graded based on prevalence of anaemia. Secondary data published in the District Level Household and Facility Survey - 4 is analysed for five states and 1 UT (Union Territory) of southern part of India. Choropleth Mapping was done to visually depict the intensity of anaemia problem across the geographic territories. Results Children from 6 months to 59 months were having highest prevalence of both, anaemia (68%) and severe anaemia (10%). This was followed by pregnant women aged 15 to 49 years and Girl Child 6 to 9 years. Four of the Southern states of India including Andhra Pradesh, Karnataka, Telangana and Tamil Nadu fall in the Grade 2 SPHP (Severe Public Health Problem) Conclusion The sixteen districts fall under Grade 3 Severe Public Health Problem in the states of Andhra Pradesh, Karnataka and Telangana, require special focus for identifying and addressing the determinants of such high prevalence of Anaemia. These populations and territories require priority in the

  9. Evaluating the Role of Interdigitated Neoadjuvant Chemotherapy and Radiation in the Management of High-Grade Soft-Tissue Sarcoma

    PubMed Central

    Raval, Raju R.; Frassica, Deborah; Thornton, Katherine; Meyer, Christian; Ettinger, David S.; Frassica, Frank; Weber, Kristin; Terezakis, Stephanie A.

    2016-01-01

    Objectives High-grade soft-tissue sarcoma (STS) has a poor prognosis. The goal of this study was to review treatment outcomes of patients with high-grade STS treated with interdigitated neoadjuvant chemotherapy (CT) and radiation at our institution. Materials and Methods Patients with high-grade STS (1997 to 2010) were planned for treatment with 3 cycles of neoadjuvant CT, interdigitated preoperative radiation therapy (44 Gy administered in split courses with a potential 16 Gy postoperative boost), and 3 cycles of postoperative CT. Cancer control outcomes at 3 years were analyzed. Results Sixteen patients with high-grade STS were evaluated. Median age was 53 years, the median longest tumor diameter was 14.6 cm, and median follow-up was 33 months. All 16 patients received 2 or 3 cycles of neoadjuvant CT and all patients completed neoadjuvant RT. The estimated 3-year rate for local control was 100%, disease-free survival 62.5%, and overall survival 73.4%. Conclusions Patients with high-grade STS treated with interdigitated neoadjuvant CT and radiation before surgical resection had excellent rates of local control, along with disease-free survival and overall survival similar to previously published reports. This combined-modality approach continues to have a role in the treatment of patients with high-grade STS. PMID:25268069

  10. Formation and exhumation mechanisms of high-grade rocks: Sagduction and Subduction processes during the Archean

    NASA Astrophysics Data System (ADS)

    François, C.; Philippot, P.; Rey, P.

    2012-04-01

    The interpretation of high-grade rocks in the Archean is controversial. Mid- to high-pressure assemblages are commonly interpreted in terms of plate tectonic processes including subduction. In the Archean however, mid- to high-pressure assemblages could have been also produced during the sagduction of greenstone covers into their crustal basement. Often put in opposition, sagduction and subduction are not incompatible processes. In order to better documents the P-T-t signatures of both processes we are conducting a comparative study - structural, metamorphic and numerical - of supposedly subduction-related metamorphic rocks described in ~3.5-3.2 Ga old Barberton greenstones (Kaapvaal Craton, South Africa) (Moyen et al., 2006), and supposedly sagduction-related high-grade rocks in the 3.5-3.2 Ga old East Pilbara Craton (Western Australia) (Delor et al., 1991). Interestingly, these two terranes display dome-and-keel structure in which narrow belts of greenstone (ultramafic and mafic metabasalts) and overlying sedimentary rocks occur in association with broad TTG (trondhjemite-tonalite-granodiorite) granitoids. We present here preliminary results from fieldwork, metamorphic investigations and numerical experiments. Petrological analyses have been conducted on metabasalts and metasediments in enclaves in migmatitic and granitic rocks, both inside and outside granitic domes. We sampled high-grade mafic rocks in enclaves within the NNE trending steeply deeping migmatitic Inyoni shear zone located between the 3.45 Ga Stolzburg pluton and the 3.2 Ga Badplass gneisses in the southern Barberton terrane (Moyen et al., 2006). Preliminary P-T estimations have been performed with multi-equilibrium approach using Thermocalc and with thermodynamic modeling using PerpleX on garnet-amphibole-clinopyroxene-epidote-plagioclase assemblage reveals pressures of 12-14 kbar at temperatures of 600-650°C for the metamorphic peak. Maximum temperature is reached at the beginning of exhumation

  11. High frequency of the X-chromosome inactivation in young female patients with high-grade glioma

    PubMed Central

    2013-01-01

    Background Gliomas are common tumors and high-grade ones account for 62% of primary malignant brain tumors. Though current evidence have suggested that inherited risks play a role in glioma susceptibility, it was conveyed that glioma was such a complex disease, and the direct genetic contribution to glioma risk factors and its relation to other factors should be discussed more deeply. X-chromosome inactivation (XCI) is the mechanism by which gene dosage equivalence is achieved between female mammals with two X chromosomes and male mammals with a single X chromosome. As skewed XCI has been linked to development of some solid tumors, including ovarian, breast, and pulmonary and esophageal carcinomas, it is challenging to elucidate the relation of skewed XCI to high-grade gliomas development. Objective The present study aimed to determine the general concordance between XCI pattern in blood cells and brain tissues, and SXCI frequencies in female patients with high-grade glioma compared to healthy controls. Methods 1,103 Chinese females without a detectable tumor and 173 female high-grade glioma patients, were detected in the study. Normal brain tissues surrounding the lesions in gliomas were obtained from 49 patients among the 173 ones, with the microdissection using a laser microdissection microscope Genomic DNA was extracted from the peripheral blood cells and the normal brain tissues from the subjects. Exon 1 of androgen receptor (AR) gene was amplified, and its products of different alleles were resolved on denaturing polyacrylamide gels and visualized after silver staining. The corrected ratios (CR) of the products before and after HpaII digestion were calculated. Results Occurrence of SXCI was detected in both the patients and controls at similar frequencies. However, the phenomenon, as defined as CR ≥ 3, was more frequent in the patients aging ≤40 (23.6%) compared to the corresponding reference group (5.1%, P <0.0001). When CR ≥ 10 was adopted

  12. ZnO/(ZnMg)O single quantum wells with high Mg content graded barriers

    SciTech Connect

    Laumer, Bernhard; Schuster, Fabian; Wassner, Thomas A.; Stutzmann, Martin; Rohnke, Marcus; Schoermann, Joerg; Eickhoff, Martin

    2012-06-01

    ZnO/Zn{sub 1-x}Mg{sub x}O single quantum wells (SQWs) were grown by plasma-assisted molecular beam epitaxy on c-plane sapphire substrates. Compositional grading allows the application of optimized growth conditions for the fabrication of Zn{sub 1-x}Mg{sub x}O barriers with high crystalline quality and a maximum Mg content of x = 0.23. High resolution x-ray diffraction reveals partial relaxation of the graded barriers. Due to exciton localization, the SQW emission is found to consist of contributions from donor-bound and free excitons. While for narrow SQWs with well width d{sub W}{<=}2.5nm, the observed increase of the exciton binding energy is caused by quantum confinement, the drop of the photoluminescence emission below the ZnO bulk value found for wide SQWs is attributed to the quantum-confined Stark effect. For a Mg content of x = 0.23, a built-in electric field of 630 kV/cm is extracted, giving rise to a decrease of the exciton binding energy and rapid thermal quenching of the SQW emission characterized by an activation energy of (24 {+-} 4) meV for d{sub W} = 8.3 nm.

  13. Sleeping Beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high grade astrocytomas

    PubMed Central

    Bender, Aaron M.; Collier, Lara S.; Rodriguez, Fausto J.; Tieu, Christina; Larson, Jon D.; Halder, Chandralekha; Mahlum, Eric; Kollmeyer, Thomas M.; Akagi, Keiko; Sarkar, Gobinda; Largaespada, David A.; Jenkins, Robert B.

    2010-01-01

    The Sleeping Beauty (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer genes. To identify glioma-associated genes, we evaluated tumor formation in brain tissue from 117 transgenic mice that had undergone constitutive SB-mediated transposition. Upon analysis, 21 samples (18%) contained neoplastic tissue with features of high grade astrocytomas. These tumors expressed glial markers and were histologically similar to human glioma. Genomic DNA from SB-induced astrocytoma tissue was extracted and transposon insertion sites were identified. Insertions in the growth factor gene Csf1 were found in 13 of the 21 tumors (62%), clustered in introns 5 and 8. Using RT-PCR, we documented increased Csf1 RNAs in tumor versus adjacent normal tissue, with identification of transposon-terminated Csf1 mRNAs in astrocytomas with SB insertions in intron 8. Analysis of human glioblastomas revealed increased levels of Csf1 RNA and protein. Together, these results indicate that SB-insertional mutagenesis can identify high-grade astrocytoma-associated genes, and they imply an important role for CSF1 in the development of these tumors. PMID:20388773

  14. Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma.

    PubMed

    Cloughesy, Timothy F; Landolfi, Joseph; Hogan, Daniel J; Bloomfield, Stephen; Carter, Bob; Chen, Clark C; Elder, J Bradley; Kalkanis, Steven N; Kesari, Santosh; Lai, Albert; Lee, Ian Y; Liau, Linda M; Mikkelsen, Tom; Nghiemphu, Phioanh Leia; Piccioni, David; Walbert, Tobias; Chu, Alice; Das, Asha; Diago, Oscar R; Gammon, Dawn; Gruber, Harry E; Hanna, Michelle; Jolly, Douglas J; Kasahara, Noriyuki; McCarthy, David; Mitchell, Leah; Ostertag, Derek; Robbins, Joan M; Rodriguez-Aguirre, Maria; Vogelbaum, Michael A

    2016-06-01

    Toca 511 (vocimagene amiretrorepvec) is an investigational nonlytic, retroviral replicating vector (RRV) that delivers a yeast cytosine deaminase, which converts subsequently administered courses of the investigational prodrug Toca FC (extended-release 5-fluorocytosine) into the antimetabolite 5-fluorouracil. Forty-five subjects with recurrent or progressive high-grade glioma were treated. The end points of this phase 1, open-label, ascending dose, multicenter trial included safety, efficacy, and molecular profiling; survival was compared to a matching subgroup from an external control. Overall survival for recurrent high-grade glioma was 13.6 months (95% confidence interval, 10.8 to 20.0) and was statistically improved relative to an external control (hazard ratio, 0.45; P = 0.003). Tumor samples from subjects surviving more than 52 weeks after Toca 511 delivery disproportionately displayed a survival-related mRNA expression signature, identifying a potential molecular signature that may correlate with treatment-related survival rather than being prognostic. Toca 511 and Toca FC show excellent tolerability, with RRV persisting in the tumor and RRV control systemically. The favorable assessment of Toca 511 and Toca FC supports confirmation in a randomized phase 2/3 trial (NCT02414165). PMID:27252174

  15. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

    PubMed

    Stock, Kristin; Kumar, Jitender; Synowitz, Michael; Petrosino, Stefania; Imperatore, Roberta; Smith, Ewan St J; Wend, Peter; Purfürst, Bettina; Nuber, Ulrike A; Gurok, Ulf; Matyash, Vitali; Wälzlein, Joo-Hee; Chirasani, Sridhar R; Dittmar, Gunnar; Cravatt, Benjamin F; Momma, Stefan; Lewin, Gary R; Ligresti, Alessia; De Petrocellis, Luciano; Cristino, Luigia; Di Marzo, Vincenzo; Kettenmann, Helmut; Glass, Rainer

    2012-08-01

    Primary astrocytomas of grade 3 or 4 according to the classification system of the World Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and are almost invariably fatal despite the use of multimodal therapy. Here we show that the juvenile brain has an endogenous defense mechanism against HGAs. Neural precursor cells (NPCs) migrate to HGAs, reduce glioma expansion and prolong survival time by releasing endovanilloids that activate the vanilloid receptor (transient receptor potential vanilloid subfamily member-1 or TRPV1) on HGA cells. TRPV1 is highly expressed in tumor and weakly expressed in tumor-free brain. TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3). The antitumorigenic response of NPCs is lost with aging. NPC-mediated tumor suppression can be mimicked in the adult brain by systemic administration of the synthetic vanilloid arvanil, suggesting that TRPV1 agonists have potential as new HGA therapeutics. PMID:22820645

  16. All reovirus subtypes show oncolytic potential in primary cells of human high-grade glioma.

    PubMed

    Alloussi, S H; Alkassar, M; Urbschat, S; Graf, N; Gärtner, B

    2011-09-01

    Reoviridae are non-human pathogenic viruses. The family of reoviridae consists of 4 different subtypes. Many studies have proven that the Dearing subtype 3 has oncolytic potential. This potential is related to the RAS protein expression in tumour cells. The aim of this study, was to investigate whether all reovirus subtypes have oncolytic potential and whether there are differences in their efficacy, in particular for high-grade glioma. To evaluate the oncolytic potential, we performed an in vitro head-to-head study for all reovirus subtypes in 5 primary cell cultures of high-grade gliomas. The oncolytic activity was determined using end-point titration with observation of the cytopathogenic effect. For measurement of RAS activity, we performed an immunofluorescent detection stain on all cell cultures. For quantification of the virus, an RT-PCR measurement for all subtypes was performed. All reovirus subtypes showed oncolytic activity in the observed glioma biopsies. These observations correlated with RAS overexpression in the observed cells. All glioma biopsies overexpressed the RAS protein. The quantitative oncolytic potential differed in relation to the single observed cell culture and in relation to the chosen reovirus subtype. To our knowledge, this is the first study showing oncolytic activity for all reovirus subtypes. We show the relationship and correlation between RAS protein overexpression and vulnerability of cells to reovirus. Efficacy of the different subtypes is interindividually different and cannot be forecast. PMID:21637921

  17. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis.

    PubMed

    Hales, Russell K; Shokek, Ori; Burger, Peter C; Paynter, Nina P; Chaichana, Kaisorn L; Quiñones-Hinojosa, Alfredo; Jallo, George I; Cohen, Kenneth J; Song, Danny Y; Carson, Benjamin S; Wharam, Moody D

    2010-08-01

    To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital between 1977 and 2004. A single neuropathologist (P.C.B.) reviewed all available histologic samples (n = 48). Log-rank analysis was used to compare survival by patient, tumor, and treatment factors. Median follow-up was 16 months for all patients and 155 months (minimum 54 months) for surviving patients. Median survival for all patients (n = 63) was 14 months with 10 long-term survivors (survival >48 months). At initial diagnosis, 27 patients were grade III (43%) and 36 grade IV (57%). Forty-eight patients had pathology slides available for review, including seven of ten long-term surviving patients. Four patients had non-HGA pathology, all of whom were long term survivors. The remaining 44 patients with confirmed HGG had a median survival of 14 months and prognostic analysis was confined to these patients. On multivariate analysis, five factors were associated with inferior survival: performance status (Lansky) <80% (13 vs. 15 months), bilaterality (13 vs. 19 months), parietal lobe location (13 vs. 16 months), resection less than gross total (13 vs. 22 months), and radiotherapy dose <50 Gy (9 vs. 16 months). Among patients with more than one of the five adverse factors (n = 27), median survival and proportion of long-term survivors were 12.9 months and 0%, compared with 41.4 months and 18% for patients with 0-1 adverse factors (n = 17). In an historical cohort of children with HGA, the potential for long term survival was confined to the subset with less than two of the following adverse prognostic factors: low performance status, bilaterality, parietal lobe site, less than gross total resection, and radiotherapy dose <50 Gy. Pathologic misdiagnosis

  18. 1p/19q-driven prognostic molecular classification for high-grade oligodendroglial tumors.

    PubMed

    Jiang, Haihui; Zhang, Zhe; Ren, Xiaohui; Zeng, Wei; Jia, Wenqing; Wang, Junmei; Lin, Song

    2014-12-01

    The subjectivity in pathological diagnosis of anaplastic oligoastrocytoma (AOA) and uncertainty in designation of glioblastoma with oligodendroglioma component (GBMO) were two major dilemmas which puzzled neuro-pathologists and neurosurgeons. The present study was designed to project a molecular classification scheme based on the status of chromosome 1p and 19q. Patients (n = 117) with histological diagnosis of primary high-grade oligodendroglial tumors (HGOs) enrolled in the study. Fluorescence in situ hybridization (FISH) for chromosomes 1p and 19q was performed. Univariate analysis showed that higher tumor grade, 1p/19q maintenance and 1q/19p co polysomy were confirmed as risk factors in HGOs (P < 0.01). Accordingly, patients with HGOs were divided into four subtypes which conferred remarkably distinct prognosis based on the number of risk factors (0 risk factor: HGOs-1, 1 risk factor: HGOs-2, 2 risk factors: HGOs-3, 3 risk factors: HGOs-4). Cox regression model revealed that the tumor grade was no longer independently associated with survival, while the molecular classification scheme showed a marked prognostic significance (HR = 0.359, 95 % CI 0.261-0.494, P < 0.001 for progression-free survival (PFS); HR = 0.393, 95 % CI 0.283-0.546, P < 0.001 for overall survival (OS)). The classification scheme incorporating traditional pathology with molecular information can be served as a supplement of the current WHO classification system and contribute to the personalized treatment decision-making. PMID:25151507

  19. The Grading Systems of Award-Winning High School Journalism Teachers in Production-Oriented Classes.

    ERIC Educational Resources Information Center

    Sparks, Mary Kahl

    Twenty-seven school journalism teachers who have been honored as "outstanding" by the Newspaper Fund in the last 3 years responded to a survey about how they grade students in production oriented classes. The teachers reported using a variety of grading systems, including subjective decision making, a combination grading system, self-evaluation,…

  20. Fourier and Wavelet Based Characterisation of the Ionospheric Response to the Solar Eclipse of August, the 11th, 1999, Measured Through 1-minute Vertical Ionospheric Sounding

    NASA Astrophysics Data System (ADS)

    Sauli, P.; Abry, P.; Boska, J.

    2004-05-01

    The aim of the present work is to study the ionospheric response induced by the solar eclipse of August, the 11th, 1999. We provide Fourier and wavelet based characterisations of the propagation of the acoustic-gravity waves induced by the solar eclipse. The analysed data consist of profiles of electron concentration. They are derived from 1-minute vertical incidence ionospheric sounding measurements, performed at the Pruhonice observatory (Czech republic, 49.9N, 14.5E). The chosen 1-minute high sampling rate aims at enabling us to specifically see modes below acoustic cut-off period. The August period was characterized by Solar Flux F10.7 = 128, steady solar wind, quiet magnetospheric conditions, a low geomagnetic activity (Dst index varies from -10 nT to -20 nT, Σ Kp index reached value of 12+). The eclipse was notably exceptional in uniform solar disk. These conditions and fact that the culmination of the solar eclipse over central Europe occurred at local noon are such that the observed ionospheric response is mainly that of the solar eclipse. We provide a full characterization of the propagation of the waves in terms of times of occurrence, group and phase velocities, propagation direction, characteristic period and lifetime of the particular wave structure. However, ionospheric vertical sounding technique enables us to deal with vertical components of each characteristic. Parameters are estimated combining Fourier and wavelet analysis. Our conclusions confirm earlier theoretical and experimental findings, reported in [Altadill et al., 2001; Farges et al., 2001; Muller-Wodarg et al.,1998] regarding the generation and propagation of gravity waves and provide complementary characterisation using wavelet approaches. We also report a new evidence for the generation and propagation of acoustic waves induced by the solar eclipse through the ionospheric F region. Up to our knowledge, this is the first time that acoustic waves can be demonstrated based on ionospheric

  1. Origin of deep crystal reflections: seismic profiling across high-grade metamorphic terranes in Canada

    USGS Publications Warehouse

    Green, A.; Milkereit, B.; Percival, J.; Davidson, A.; Parrish, R.; Cook, F.; Geis, W.; Cannon, W.; Hutchinson, D.; West, G.; Clowes, R.

    1990-01-01

    In an attempt to better understand the origin of deep crustal reflections LITHOPROBE has sponsored or co-sponsored Seismic reflection surveys across tracts of high-grade metamorphic rock in the Archean Superior craton, the Proterozoic Grenville orogen and the Phanerozoic Cordilleran orogen. Common to these three diverse terranes are near-surface zones of prominent Seismic reflectivity that are typically associated with velocity discontinuities at highly strained contacts between gneissic rocks of varying lithology. At some locations the reflective layering resulted from transposition and rearrangement of previously layered rocks (stratified assemblages, sills, etc.), whereas in other regions it was generated by extreme attenuation, stretching and ductile flow of weakly layered or irregularly organized rocks. It seems likely that compositionally layered gneissic rock is a common source of reflections in the deep crust, with reflections originating at lithological boundaries and zones of mylonite. ?? 1990.

  2. Study of X80 grade high strength line pipe for sour service

    SciTech Connect

    Kushida, T.; Okaguchi, S.; Hamada, M.; Yamamoto, A.; Ohnishi, K.; Fujino, J.

    1997-08-01

    X80 grade high strength large diameter line pipe (UOE Pipe) for sour service have been studied. Increasing Mn content to provide strength of X80 increases HIC susceptibility due to center segregation of Mn in continuously cast slabs. The Mn content should be controlled less than 1.4% to maintain HIC resistance in the NACE TM0177 solution. The required strength can be obtained by addition of 0.5% Cr and accelerated controlled cooling after rolling. It has been clarified that Cr is very useful in providing high strength X70 without accelerating the center segregation of Mn. SSC resistance can be improved by controlling maximum hardness of weld metal lower than 230 Hv. Sour service X80 UOE pipes of two sizes were manufactured on large scales based on these experimental results. These pipes showed good low temperature toughness and HIC resistance in the NACE TM0177 solution.

  3. Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape.

    PubMed

    Haugvik, Sven-Petter; Kaemmerer, Daniel; Gaujoux, Sebastien; Labori, Knut Jørgen; Verbeke, Caroline Sophie; Gladhaug, Ivar Prydz

    2016-05-01

    Pancreatic neuroendocrine neoplasms (PNENs) are rare, accounting for less than 5 % of all pancreatic tumors. High-grade pancreatic neuroendocrine carcinomas (hgPNECs) represent about 5 % of all PNENs. They show highly aggressive behavior with dismal prognosis. Throughout the last two decades, there has been a notable progress in basic and clinical research of PNENs and a therapeutic trend towards both more aggressive and minimally invasive surgery. Despite these advances, hgPNECs as a distinct clinical entity remains largely unexplored among surgeons. This review of current development in pathology reporting and surgical treatment of hgPNECs aims at increasing the awareness of an evolving field in pancreatic surgery. PMID:26984415

  4. ADVANCED MR IMAGING METHODS FOR PLANNING AND MONITORING RADIATION THERAPY IN PATIENTS WITH HIGH GRADE GLIOMA

    PubMed Central

    Lupo, Janine M.; Nelson, Sarah J.

    2016-01-01

    This review explores how the integration of advanced imaging methods with high quality anatomic images significantly improves the characterization, target definition, assessment of response to therapy, and overall management of patients with high-grade glioma. Metrics derived from diffusion, perfusion, and susceptibility weighted MR imaging in conjunction with MR spectroscopic imaging, allows us to characterize regions of edema, hypoxia, increased cellularity, and necrosis within heterogeneous tumor and surrounding brain tissue. Quantification of such measures may provide a more reliable initial representation of tumor delineation and response to therapy than changes in the contrast enhancing or T2 lesion alone and have a significant impact on targeting resection, planning radiation, and assessing treatment effectiveness. In the long-term, implementation of these imaging methodologies can also aid in the identification of recurrent tumor and its differentiation from treatment-related confounds and facilitate the detection of radiation-induced vascular injury in otherwise normal appearing brain tissue. PMID:25219809

  5. CIGS absorber layer with double grading Ga profile for highly efficient solar cells

    NASA Astrophysics Data System (ADS)

    Saadat, M.; Moradi, M.; Zahedifar, M.

    2016-04-01

    It is well-known that the band gap grading in CIGS solar cells is crucial for achieving highly efficient solar cells. We stimulate a CIGS solar cell and investigate the effects of the band gap grading on performance of the CIGS solar cell, where Ga/(Ga + In) ratio (GGI) at back (Cb) and front (Cf) of the absorber layer are considered constant. Our simulations show that by increasing the GGI at middle of CIGS absorber layer (Cm), the JSC decreases and VOC increases independent of the distance of the Cm from the back contact (Xm). For Cm lower than Cf, JSC increases and VOC decreases when the Xm shifts to the front of the CIGS layer. The behavior of JSC and VOC became reverse for the case of Cm greater than Cf. Almost in all of the structures, efficiency and FF have same behaviors. Our simulations show that the highest efficiency is obtained at Cm = 0.8 and Xm = 200 nm.

  6. Development of high-purity optical grade single-crystal CVD diamond for intracavity cooling

    NASA Astrophysics Data System (ADS)

    Bennett, Andrew M.; Wickham, Benjamin J.; Dhillon, Harpreet K.; Chen, Ying; Webster, Scott; Turri, Giorgio; Bass, Michael

    2014-02-01

    Microwave assisted chemical vapour deposited bulk diamond products have been used in a range of high power laser systems, due to low absorption across a range of wavelengths and exceptional thermal properties. However the application of polycrystalline products has frequently been limited to applications at longer wavelengths or thermal uses outside of the optical path due to the birefringence and scatter that are intrinsic properties of the polycrystalline materials. However, there are some solid state structures, including thin disc gain modules and amplifiers, that will gain significantly in terms of potential output powers if diamond could be used as a heat spreader in the optical path as well as a heat spreader on the rear surface of the disk. Therefore single crystal grades of diamond have been developed that overcome the limitations of the polycrystalline material, with low absorption, low scatter and low birefringence grades for demanding optical applications. We will present new data, characterising the performance of these materials across infra-red and visible wavelengths with absorption coefficient measured by laser calorimetry at a range of wavelengths from 1064 nm to 452 nm.

  7. Management of high-grade stage I adenocarcinoma of the endometrium: hysterectomy following low dose external beam pelvic irradiation

    SciTech Connect

    Shimm, D.S.; Wang, C.C.; Fuller, A.F. Jr.; Nelson, J.H. Jr.; Nikrui, N.; Young, R.H.; Scully, R.E.

    1986-02-01

    Sixty-eight patients with FIGO stage I, grade 2 or 3 adenocarcinoma of the endometrium were treated according to a protocol involving 10 Gy external pelvic irradiation, prompt hysterectomy with surgical staging, and postoperative therapy individualized according to surgical-pathologic findings. Five-year survival for the entire group was 78%, 87% for those with grade 2 disease, and 59% for those with grade 3 disease. For patients whose disease was found to be confined to the uterus, surgical stage I, the 5-year survival was 98%. Patients with surgical stage I, grades 2 and 3 disease had 97 and 100% probabilities of surviving 5 years, respectively. Five-year disease-free probability was 96% for all patients with surgical stage I carcinoma, 97% for patients with grade 2 disease, and 94% for patients with grade 3 disease. Myometrial penetration influenced survival; no patient with less than 50% myometrial penetration died or suffered a relapse, while only 40% of patients with deeper penetration survived 5 years. Twenty-three percent of patients with surgically confirmed disease spread beyond the corpus survived 5 years; 29% remained disease-free at this interval. Ten of the 68 patients developed recurrences, none has had a known pelvic recurrence. Two major complications, one requiring surgery, were seen, both in patients receiving postoperative external beam irradiation. The rationale behind low-dose, preoperative external pelvic irradiation is described, and an approach to high-grade, FIGO stage I adenocarcinoma of the endometrium is outlined.

  8. High Risk HPV E6/E7 Oncoprotein Expression in Women with High Grade Squamous Intraepithelial Lesion.

    PubMed

    Valença, Jefferson Elias Cordeiro; Gonçalves, Ana Katherine; Guerreiro da Silva, Ismael Dale Cotrim; Eleutério Junior, José; Tenório da Silva, Terezinha; Bruneska, Danyelly; Ximenes, Ricardo Arraes de Alencar

    2016-03-01

    Purpose To correlate the expression of high-risk HPV E6 mRNA with pap smear, colposcopy, and biopsy results in women with high grade squamous intraepithelial lesion (HSIL). Methods A cross-sectional study was performed on women referred for primary care services after cytological diagnosis of HSIL. We evaluated the expression of E6/E7 mRNA of HPV types 16,18,31,33, and 45 and correlated the results with those of Pap smear, colposcopy, and biopsy. For amplification/detection of mRNA E6 / E7 we used NucliSENSEasyQ kit to detect HPV mRNA by polymerase chain reaction with primers/probes for HPV types 16, 18, 31, 33, and 45. Results Out of 128 valid tests, the results of 30 (23.4%) tests were negative and 98 (70%) tests were positive. Only one type of HPV was detected in 87.7% of the E6/E7 mRNA positive cases. HPV16 was detected in 61.2% of the cases, followed by HPV33 (26.5%), HPV31 (17.3%), HPV18 (10%), and HPV45 (4.08%). Pap smear tests revealed that the E6/E7 test was positive in 107 (83.8%) women with atypical squamous cells - high grade (ASC-H), HSIL, or higher. The E6/E7 test was positive in 69 (57.5%) specimens presenting negative cytology results. When analyzing the association with colposcopy results, the frequency of positive E6/E7 results increased with the severity of the injury, ranging from 57.1% in women without colposcopy-detected injury to 86.5% in those with higher levels of colposcopy findings. Of the 111 women who underwent biopsy and E6/E7 testing, the E6/E7 test was positive in 84.7% of the women who presented with lesions of cervical intraepithelial neoplasia (CIN) grade 2 or higher. Finally, 41.2% of women with a negative biopsy presented a positive E6/E7 test. Conclusions E6/E7 mRNA expression was higher in women with HSIL and CIN grade 2 or higher. PMID:27022787

  9. Digital Mammography Screening: Does Age Influence the Detection Rates of Low-, Intermediate-, and High-Grade Ductal Carcinoma in Situ?

    PubMed

    Weigel, Stefanie; Hense, Hans W; Heidrich, Jan; Berkemeyer, Shoma; Heindel, Walter; Heidinger, Oliver

    2016-03-01

    Purpose To investigate the association between age at screening and detection rates for ductal carcinoma in situ (DCIS) separately for different nuclear grades after introduction of a population-based digital mammography screening program. Materials and Methods The retrospective study was approved by the ethics board and did not require informed consent. In 733 905 women aged 50-69 years who participated in a screening program for the first time in 2005-2008 (baseline examinations were performed with digital mammography), DCIS detection rates were determined for 5-year age groups (detection rates per 1000 women screened) to distinguish high-, intermediate-, and low-grade DCIS. Multivariable logistic regression was used to compare detection rates between age groups by adjusting for screening units (P < .05). Results There were 989 graded DCIS diagnoses among 733 905 women (detection rate, 1.35‰): 419 diagnoses of high-grade DCIS (detection rate, 0.57‰), 388 diagnoses of intermediate-grade DCIS (detection rate, 0.53‰), and 182 diagnoses of low-grade DCIS (detection rate, 0.25‰). Detection rate for types of DCIS combined increased significantly across age groups (50-54 years, detection rate of 1.15‰ [254 of 220 985 women]; 55-59 years, detection rate of 1.23‰ [218 of 177 782 women]; 60-64 years, detection rate of 1.34‰ [201 of 150 415 women]; and 65-69 years, detection rate of 1.71‰ [316 of 184 723 women]; P < .001). Of note, the detection rate for high-grade DCIS showed a significant increase with age (odds ratio, 1.18 per 5-year age group; P < .0001). The increase was lower for intermediate-grade DCIS (odds ratio, 1.11; P = .016) and not significant for low-grade DCIS (P = .10). Conclusion Total DCIS detection rates increase with age, mostly because of an increase in high- and intermediate-grade DCIS, which are precursor lesions that carry a higher risk for transition to more aggressive invasive breast cancer than low-grade DCIS. (©) RSNA, 2015

  10. Origin and molecular pathogenesis of ovarian high-grade serous carcinoma.

    PubMed

    Kurman, R J

    2013-12-01

    A new paradigm for the pathogenesis of ovarian cancer has recently been proposed which helps to explain persistent problems in describing the development and diverse morphology of these neoplasms. The paradigm incorporates recent advances in our understanding of the molecular pathogenesis of epithelial 'ovarian' cancer with new insights into the origin of these tumors. Correlated clinicopathologic and molecular genetic studies led to the development of a dualistic model that divides all the various histologic types of epithelial ovarian carcinomas into two broad categories designated 'type I' and 'type II'. The prototypic type I tumor is low-grade serous carcinoma and the prototypic type II tumor is high-grade serous carcinomas (HGSCs). As the serous tumors comprise ∼70% of all epithelial ovarian tumors and account for the majority of deaths, the serous tumors will be the subject of this review. There are marked differences between the low-grade and high-grade serous tumors. Briefly, the former are indolent, present in stage I (tumor confined to the ovary) and develop from well-established precursors, so-called 'atypical proliferative (borderline) tumors,' which are characterized by specific mutations, including KRAS, BRAF and ERBB2; they are relatively genetically stable. In contrast, HGSCs are aggressive, present in the advanced stage, and develop from intraepithelial carcinomas in the fallopian tube. They harbor TP53 mutations in over 95% of cases, but rarely harbor the mutations detected in the low-grade serous tumors. At the time of diagnosis they demonstrate marked chromosomal aberrations but over the course of the disease these changes remain relatively stable. Along with the recent advances in understanding the molecular pathogenesis of these tumors, studies have demonstrated that the long sought for precursor of ovarian HGSC appears to develop from an occult intraepithelial carcinoma in the fimbrial region of the fallopian tube designated 'serous tubal

  11. Prognostic Significance of Telomere Maintenance Mechanisms in Pediatric High-Grade Gliomas

    PubMed Central

    Dorris, Kathleen; Sobo, Matthew; Onar-Thomas, Arzu; Panditharatna, Eshini; Stevenson, Charles B.; Gardner, Sharon L.; DeWire, Mariko D.; Pierson, Christopher R.; Olshefski, Randal; Rempel, Sandra A.; Goldman, Stewart; Miles, Lili; Fouladi, Maryam; Drissi, Rachid

    2014-01-01

    Background Children with high-grade glioma, including diffuse intrinsic pontine glioma (DIPG), have a poor prognosis despite multimodal therapy. Identifying novel therapeutic targets is critical to improve their outcome. We evaluated prognostic roles of telomere maintenance mechanisms in children with HGG, including DIPG. Methods A multi-institutional retrospective study was conducted involving 50 flash-frozen HGG (35 non-brainstem; 15 DIPG) tumors from 45 children (30 non-brainstem; 15 DIPG). Telomerase activity, expression of hTERT mRNA (encoding telomerase catalytic component) and TERC (telomerase RNA template) and alternative lengthening of telomeres (ALT) mechanism were assayed. Cox Proportional Hazard regression analyses assessed association of clinical and pathological variables, TERC and hTERT levels, telomerase activity, and ALT use with progression-free or overall survival (OS). Results High TERC and hTERT expression was detected in 13/28 non-brainstem HGG samples as compared to non-neoplastic controls. High TERC and hTERT expression was identified in 13/15 and 11/15 DIPG samples, respectively, compared to controls. Evidence of ALT was noted in 3/11 DIPG and 10/19 non-brainstem HGG specimens. ALT and telomerase use were identified in 4/19 non-brainstem HGG and 2/11 DIPG specimens. In multivariable analyses, increased TERC and hTERT levels were associated with worse OS in patients with non-brainstem HGG, after controlling for tumor grade or resection extent. Conclusions Children with HGG and DIPG, have increased hTERT and TERC expression. In children with non-brainstem HGG, increased TERC and hTERT expression levels are associated with a worse OS, making telomerase a promising potential therapeutic target in pediatric HGG. PMID:24477622

  12. Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.

    PubMed

    Lamborn, Kathleen R; Yung, W K Alfred; Chang, Susan M; Wen, Patrick Y; Cloughesy, Timothy F; DeAngelis, Lisa M; Robins, H Ian; Lieberman, Frank S; Fine, Howard A; Fink, Karen L; Junck, Larry; Abrey, Lauren; Gilbert, Mark R; Mehta, Minesh; Kuhn, John G; Aldape, Kenneth D; Hibberts, Janelle; Peterson, Pamela M; Prados, Michael D

    2008-04-01

    The North American Brain Tumor Consortium (NABTC) uses 6-month progression-free survival (6moPFS) as the efficacy end point of therapy trials for adult patients with recurrent high-grade gliomas. In this study, we investigated whether progression status at 6 months predicts survival from that time, implying the potential for prolonged survival if progression could be delayed. We also evaluated earlier time points to determine whether the time of progression assessment alters the strength of the prediction. Data were from 596 patient enrollments (159 with grade III gliomas and 437 with grade IV tumors) in NABTC phase II protocols between February 1998 and December 2002. Outcome was assessed statistically using Kaplan-Meier curves and Cox proportional hazards models. Median survivals were 39 and 30 weeks for patients with grade III and grade IV tumors, respectively. Twenty-eight percent of patients with grade III and 16% of patients with grade IV tumors had progression-free survival of >26 weeks. Progression status at 9, 18, and 26 weeks predicted survival from those times for patients with grade III or grade IV tumors (p < 0.001 and hazard ratios < 0.5 in all cases). Including KPS, age, number of prior chemotherapies, and response in a multivariate model did not substantively change the results. Progression status at 6 months is a strong predictor of survival, and 6moPFS is a valid end point for trials of therapy for recurrent malignant glioma. Earlier assessments of progression status also predicted survival and may be incorporated in the design of future clinical trials. PMID:18356283

  13. Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas

    PubMed Central

    Lamborn, Kathleen R.; Alfred Yung, W. K.; Chang, Susan M.; Wen, Patrick Y.; Cloughesy, Timothy F.; DeAngelis, Lisa M.; Robins, H. Ian; Lieberman, Frank S.; Fine, Howard A.; Fink, Karen L.; Junck, Larry; Abrey, Lauren; Gilbert, Mark R.; Mehta, Minesh; Kuhn, John G.; Aldape, Kenneth D.; Hibberts, Janelle; Peterson, Pamela M.; Prados, Michael D.

    2008-01-01

    The North American Brain Tumor Consortium (NABTC) uses 6-month progression-free survival (6moPFS) as the efficacy end point of therapy trials for adult patients with recurrent high-grade gliomas. In this study, we investigated whether progression status at 6 months predicts survival from that time, implying the potential for prolonged survival if progression could be delayed. We also evaluated earlier time points to determine whether the time of progression assessment alters the strength of the prediction. Data were from 596 patient enrollments (159 with grade III gliomas and 437 with grade IV tumors) in NABTC phase II protocols between February 1998 and December 2002. Outcome was assessed statistically using Kaplan-Meier curves and Cox proportional hazards models. Median survivals were 39 and 30 weeks for patients with grade III and grade IV tumors, respectively. Twenty-eight percent of patients with grade III and 16% of patients with grade IV tumors had progression-free survival of >26 weeks. Progression status at 9, 18, and 26 weeks predicted survival from those times for patients with grade III or grade IV tumors (p < 0.001 and hazard ratios < 0.5 in all cases). Including KPS, age, number of prior chemotherapies, and response in a multivariate model did not substantively change the results. Progression status at 6 months is a strong predictor of survival, and 6moPFS is a valid end point for trials of therapy for recurrent malignant glioma. Earlier assessments of progression status also predicted survival and may be incorporated in the design of future clinical trials. PMID:18356283

  14. THE PRE-TECHNICAL PROJECT, A DEMONSTRATION IN EDUCATION FOR TECHNOLOGY. MEDICAL TECHNOLOGY, 11TH AND 12TH YEAR.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY.

    MEDICAL TECHNOLOGY IS ONE OF THREE OFFERINGS OF THE PRETECHNICAL PROJECT DESIGNED TO REMOTIVATE UNDERACHIEVING HIGH SCHOOL STUDENTS WHO, UPON SUCCESSFUL COMPLETION OF THE PROGRAM, MAY BE ADMITTED TO THE CAREER PROGRAMS OF THE COMMUNITY COLLEGE. DEVELOPED BY A COMMITTEE OF TEACHERS AT THE LOCAL LEVEL, THE MANUAL IS INTENDED TO ASSIST TEACHERS,…

  15. Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France - 10th-11th centuries AD).

    PubMed

    Colombo, Antony; Saint-Pierre, Christophe; Naji, Stephan; Panuel, Michel; Coqueugniot, Hélène; Dutour, Olivier

    2015-06-01

    In 2008, a skeleton of a 1 - 2.5-year-old child radiocarbon dated from the 10th - 11th century AD was discovered on the oppidum of La Granède (Millau, France). It presents multiple cranial osteolytic lesions having punched-out or geographical map-like aspects associated with sequestrum and costal osteitis. A multi 3D digital approach (CT, μCT and virtual reconstruction) enabled us to refine the description and identify the diploic origin of the lytic process. Furthermore, precise observation of the extent of the lesions and associated reorganization of the skeletal micro-structure were possible. From these convergent pieces of evidence, the differential diagnosis led to three possibilities: Langerhans cell histiocytosis, tuberculosis, or Langerhans cell histiocytosis and tuberculosis. PMID:25747815

  16. Why is weapons grade plutonium more hazardous to work with than highly enriched uranium?

    DOE PAGESBeta

    Cournoyer, Michael E.; Costigan, Stephen A.; Schake, Bradley S.

    2015-07-01

    Highly Enriched Uranium and Weapons grade plutonium have assumed positions of dominant importance among the actinide elements because of their successful uses as explosive ingredients in nuclear weapons and the place they hold as key materials in the development of industrial use of nuclear power. While most chemists are familiar with the practical interest concerning HEU and WG Pu, fewer know the subtleties among their hazards. In this study, a primer is provided regarding the hazards associated with working with HEU and WG Pu metals and oxides. The care that must be taken to safely handle these materials is emphasizedmore » and the extent of the hazards is described. The controls needed to work with HEU and WG Pu metals and oxides are differentiated. Given the choice, one would rather work with HEU metal and oxides than WG Pu metal and oxides.« less

  17. Why is weapons grade plutonium more hazardous to work with than highly enriched uranium?

    SciTech Connect

    Cournoyer, Michael E.; Costigan, Stephen A.; Schake, Bradley S.

    2015-08-01

    Highly Enriched Uranium and Weapons grade plutonium have assumed positions of dominant importance among the actinide elements because of their successful uses as explosive ingredients in nuclear weapons and the place they hold as key materials in the development of industrial use of nuclear power. While most chemists are familiar with the practical interest concerning HEU and WG Pu, fewer know the subtleties among their hazards. In this study, a primer is provided regarding the hazards associated with working with HEU and WG Pu metals and oxides. The care that must be taken to safely handle these materials is emphasized and the extent of the hazards is described. The controls needed to work with HEU and WG Pu metals and oxides are differentiated. Given the choice, one would rather work with HEU metal and oxides than WG Pu metal and oxides.

  18. High grade anorectal stricture complicating Crohn's disease: endoscopic treatment using insulated-tip knife

    PubMed Central

    Chon, Hyung Ku; Shin, Ik Sang; Kim, Sang Wook

    2016-01-01

    Endoscopic treatments have emerged as an alternative to surgery, in the treatment of benign colorectal stricture. Unlike endoscopic balloon dilatation, there is limited data on endoscopic electrocautery incision therapy for benign colorectal stricture, especially with regards to safety and long-term patency. We present a case of a 29-year-old female with Crohn's disease who had difficulty in defecation and passing thin stools. A pelvic magnetic resonance imaging scan, gastrograffin enema, and sigmoidoscopy showed a high-grade anorectal stricture. An endoscopic insulated-tip knife incision was successfully performed to resolve the problem. From our experience, we suggest that endoscopic insulated-tip knife treatment may be a feasible and effective modality for patients with short-segment, very rigid, fibrotic anorectal stricture. PMID:27433152

  19. Primary T-cell high-grade lymphoma of the feline uterus

    PubMed Central

    AZAKAMI, Daigo; ONOZAWA, Eri; MIYABE, Masahiro; OCHIAI, Kazuhiko; MICHISHITA, Masaki; HIRANO, Taichi; MOMOTA, Yutaka; ISHIOKA, Katsumi; SAKO, Toshinori

    2016-01-01

    A 12-year-old female American shorthair cat presented with a one-month history of hematuria and general lethargy. Abdominal ultrasonography revealed complete thickening of the left uterine wall. At a diagnostic laparotomy, a large mass arising from the left uterine horn was discovered, and ovariohysterectomy was performed. Histological diagnosis revealed a T-cell high-grade lymphoma of the uterus. After the ovariohysterectomy, the patient achieved complete remission and was maintained by combination chemotherapy from 14 days after surgery. However, relapse occurred in the urinary bladder wall on day 287, and the patient died of postrenal acute renal failure on day 310. This is the first report of a feline case of primary uterine lymphoma that was treated with ovariohysterectomy followed by systemic chemotherapy. PMID:26860355

  20. Sinus pauses and high-grade atrioventricular block in Albright's hereditary osteodystrophy with pseudopseudohypoparathyroidism

    PubMed Central

    Rahmat, N; Venables, P

    2013-01-01

    Albright's hereditary osteodystrophy (AHO) is a rare inherited syndrome involving the molecular defects in the gene encoding the α subunit of the stimulatory G protein (Gsα). AHO has several variants, mainly pseudohypoparathyroidism (PHP) and pseudopseudohypoparathyroidism (PPHP). We present a family that share the same inactivating GNAS1 mutation, the daughter being affected by PPHP and her late father with PHP. The daughter, in her late teens, presented with a long history of presyncopal and syncopal attacks. Her father died suddenly in his mid-40 s. As expected, her laboratory tests to date have shown normal biochemistry and hormonal levels. Subsequently, an implantable loop recorder was inserted. This demonstrated extreme sinus pauses of >11 s and also high-grade atrioventricular block. A dual-chamber pacemaker was therefore inserted. PMID:23814007

  1. Barrett's esophagus with high-grade dysplasia: Focus on current treatment options

    PubMed Central

    Lekakos, Leonidas; Karidis, Nikolaos P; Dimitroulis, Dimitrios; Tsigris, Christos; Kouraklis, Gregory; Nikiteas, Nikolaos

    2011-01-01

    High-grade dysplasia (HGD) in Barrett’s esophagus (BE) is the critical step before invasive esophageal adenocarcinoma. Although its natural history remains unclear, an aggressive therapeutic approach is usually indicated. Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium. In healthy patients with reasonable life expectancy, vagal-sparing esophagectomy, with associated low mortality and low early and late postoperative morbidity, is considered the treatment of choice for BE with HGD. Patients unfit for surgery should be managed in a less aggressive manner, using endoscopic ablation or endoscopic mucosal resection of the entire BE segment, followed by lifelong surveillance. Patients eligible for surgery who present with a long BE segment, multifocal dysplastic lesions, severe reflux symptoms, a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment, either surgical or endoscopic. PMID:22072848

  2. High grade anorectal stricture complicating Crohn's disease: endoscopic treatment using insulated-tip knife.

    PubMed

    Chon, Hyung Ku; Shin, Ik Sang; Kim, Sang Wook; Lee, Soo Teik

    2016-07-01

    Endoscopic treatments have emerged as an alternative to surgery, in the treatment of benign colorectal stricture. Unlike endoscopic balloon dilatation, there is limited data on endoscopic electrocautery incision therapy for benign colorectal stricture, especially with regards to safety and long-term patency. We present a case of a 29-year-old female with Crohn's disease who had difficulty in defecation and passing thin stools. A pelvic magnetic resonance imaging scan, gastrograffin enema, and sigmoidoscopy showed a high-grade anorectal stricture. An endoscopic insulated-tip knife incision was successfully performed to resolve the problem. From our experience, we suggest that endoscopic insulated-tip knife treatment may be a feasible and effective modality for patients with short-segment, very rigid, fibrotic anorectal stricture. PMID:27433152

  3. Induction of high grade astrocytoma (HGA) by protons: Molecular mechanisms and RBE considerations

    NASA Astrophysics Data System (ADS)

    Dalrymple, G. V.; Leichner, P. K.; Harrison, K. A.; Cox, A. B.; Hardy, K. A.; Salmon, Y. L.; Mitchell, J. C.

    1994-10-01

    Protons of a specific energy, 55 MeV, have been found to induce primary high grade astrocytomas (HGA) in the Rhesus monkey (Macaca mulatta). Brain tumors of this type were not induced by protons of other energies (32-2,300 MeV). Induction of HGA has been identified in human patients who have had radiation therapy to the head. We believe that the induction of HGA in the monkey is a consequence of dose distribution, not some unique ``toxic'' property of protons. Comparison of the human experience with the monkey data indicates the RBE for induction of brain tumors to be about one. It is unlikely that protons cause an unusual change in oncogenic expression, as compared to conventional electromagnetic radiation.

  4. Why is weapons grade plutonium more hazardous to work with than highly enriched uranium?

    SciTech Connect

    Cournoyer, Michael E.; Costigan, Stephen A.; Schake, Bradley S.

    2015-07-01

    Highly Enriched Uranium and Weapons grade plutonium have assumed positions of dominant importance among the actinide elements because of their successful uses as explosive ingredients in nuclear weapons and the place they hold as key materials in the development of industrial use of nuclear power. While most chemists are familiar with the practical interest concerning HEU and WG Pu, fewer know the subtleties among their hazards. In this study, a primer is provided regarding the hazards associated with working with HEU and WG Pu metals and oxides. The care that must be taken to safely handle these materials is emphasized and the extent of the hazards is described. The controls needed to work with HEU and WG Pu metals and oxides are differentiated. Given the choice, one would rather work with HEU metal and oxides than WG Pu metal and oxides.

  5. Primary T-cell high-grade lymphoma of the feline uterus.

    PubMed

    Azakami, Daigo; Onozawa, Eri; Miyabe, Masahiro; Ochiai, Kazuhiko; Michishita, Masaki; Hirano, Taichi; Momota, Yutaka; Ishioka, Katsumi; Sako, Toshinori

    2016-06-01

    A 12-year-old female American shorthair cat presented with a one-month history of hematuria and general lethargy. Abdominal ultrasonography revealed complete thickening of the left uterine wall. At a diagnostic laparotomy, a large mass arising from the left uterine horn was discovered, and ovariohysterectomy was performed. Histological diagnosis revealed a T-cell high-grade lymphoma of the uterus. After the ovariohysterectomy, the patient achieved complete remission and was maintained by combination chemotherapy from 14 days after surgery. However, relapse occurred in the urinary bladder wall on day 287, and the patient died of postrenal acute renal failure on day 310. This is the first report of a feline case of primary uterine lymphoma that was treated with ovariohysterectomy followed by systemic chemotherapy. PMID:26860355

  6. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.

    PubMed

    Zhang, Hui; Liu, Tao; Zhang, Zhen; Payne, Samuel H; Zhang, Bai; McDermott, Jason E; Zhou, Jian-Ying; Petyuk, Vladislav A; Chen, Li; Ray, Debjit; Sun, Shisheng; Yang, Feng; Chen, Lijun; Wang, Jing; Shah, Punit; Cha, Seong Won; Aiyetan, Paul; Woo, Sunghee; Tian, Yuan; Gritsenko, Marina A; Clauss, Therese R; Choi, Caitlin; Monroe, Matthew E; Thomas, Stefani; Nie, Song; Wu, Chaochao; Moore, Ronald J; Yu, Kun-Hsing; Tabb, David L; Fenyö, David; Bafna, Vineet; Wang, Yue; Rodriguez, Henry; Boja, Emily S; Hiltke, Tara; Rivers, Robert C; Sokoll, Lori; Zhu, Heng; Shih, Ie-Ming; Cope, Leslie; Pandey, Akhilesh; Zhang, Bing; Snyder, Michael P; Levine, Douglas A; Smith, Richard D; Chan, Daniel W; Rodland, Karin D

    2016-07-28

    To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these findings provide a view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC. VIDEO ABSTRACT. PMID:27372738

  7. The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer.

    PubMed

    Kuner, Ruprecht; Fälth, Maria; Pressinotti, Nicole Chui; Brase, Jan C; Puig, Sabrina Balaguer; Metzger, Jennifer; Gade, Stephan; Schäfer, Georg; Bartsch, Georg; Steiner, Eberhard; Klocker, Helmut; Sültmann, Holger

    2013-02-01

    Loss of cell cycle control is a prerequisite for cancer onset and progression. In prostate cancer, increased activity of cell cycle genes has been associated with prognostic parameters such as biochemical relapse and survival. The identification of novel oncogenic and druggable targets in patient subgroups with poor prognosis may help to develop targeted therapy approaches. We analyzed prostate cancer and corresponding benign tissues (n = 98) using microarrays. The comparison of high- and low-grade tumors (Gleason score ≥ 4 + 3 vs. ≤ 3 + 4) revealed 144 differentially expressed genes (p < 0.05). Out of these, 15 genes were involved in the cell cycle process. The gene maternal embryonic leucine zipper kinase (MELK) was identified to be highly correlated with cell cycle genes like UBE2C, TOP2A, CCNB2, and AURKB. Increased MELK gene expression in high-risk prostate cancer was validated by qPCR in an independent patient cohort (p < 0.005, n = 79). Immunohistochemistry analysis using a tissue microarray (n = 94) revealed increased MELK protein expression in prostate cancer tissues of high Gleason scores. RNAi-based inhibition of MELK in PC3 and LNCaP cells suggested putative function in chromatin modification, embryonic development and cell migration. The concerted inhibition of MELK and other cell cycle targets by the antibiotic siomycin A strongly impaired cell viability of prostate cancer cells, and may point to a novel therapy approach for a subset of high-risk prostate cancer patients. PMID:22945237

  8. Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis.

    PubMed

    Lu, X; Lv, X D; Ren, Y H; Yang, W D; Li, Z B; Zhang, L; Bai, X F

    2016-01-01

    Despite extensive research, the prognosis of high-grade glioblastoma multiforme (GBM) has improved only slightly because of the limited response to standard treatments. Recent advances (discoveries of molecular biomarkers) provide new opportunities for the treatment of GBM. The aim of the present study was to identify diagnostic biomarkers of high-grade GBM. First, we combined 3 microarray expression datasets to screen them for genes differentially expressed in patients with high-grade GBM relative to healthy subjects. Next, the target network was constructed via the empirical Bayesian coexpression approach, and centrality analysis and a molecular complex detection (MCODE) algorithm were performed to explore hub genes and functional modules. Finally, a validation test was conducted to verify the bioinformatic results. A total of 277 differentially expressed genes were identified according to the criteria P < 0.05 and |log2(fold change)| ≥ 1.5. These genes were most significantly enriched in the cell cycle pathway. Centrality analysis uncovered 9 hub genes; among them, TFDP1 showed the highest degree of connectivity (43) and is a known participant in the cell cycle pathway; this finding pointed to the important role of TFDP1 in the progression of high-grade GBM. Experimental validation mostly supported the bioinformatic results. According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade GBM; this result may provide new insights into the pathogenesis of GBM. PMID:27323154

  9. Hypofractionated Stereotactic Radiation Therapy in Recurrent High-Grade Glioma: A New Challenge

    PubMed Central

    Navarria, Pierina; Ascolese, Anna Maria; Tomatis, Stefano; Reggiori, Giacomo; Clerici, Elena; Villa, Elisa; Maggi, Giulia; Bello, Lorenzo; Pessina, Federico; Cozzi, Luca; Scorsetti, Marta

    2016-01-01

    Purpose The aim of this study was to evaluate outcomes of hypofractionated stereotactic radiation therapy (HSRT) in patients re-treated for recurrent high-grade glioma. Materials and Methods From January 2006 to September 2013, 25 patients were treated. Six patients underwent radiation therapy alone, while 19 underwent combined treatment with surgery and/or chemotherapy. Only patients with Karnofsky Performance Status (KPS) > 70 and time from previous radiotherapy greater than 6 months were re-irradiated. The mean recurrent tumor volume was 35 cm3 (range, 2.46 to 116.7 cm3), and most of the patients (84%) were treated with a total dose of 25 Gy in five fractions (range, 20 to 50 Gy in 5-10 fractions). Results The median follow-up was 18 months (range, 4 to 36 months). The progression-free survival (PFS) at 1 and 2 years was 72% and 34% and the overall survival (OS) 76% and 50%, respectively. No severe toxicity was recorded. In univariate and multivariate analysis extent of resection at diagnosis significantly influenced PFS and OS (p < 0.01). Patients with smaller recurren tumor volume treated had better local control and survival. Indeed, the 2-year PFS was 40% (≤ 50 cm3) versus 11% (p=0.1) and the 2-year OS 56% versus 33% (> 50 cm3), respectively (p=0.26). Conclusion In our experience, HSRT could be a safe and feasible therapeutic option for recurrent high grade glioma even in patients with larger tumors. We believe that a multidisciplinary evaluation is mandatory to assure the best treatment for selected patients. Local treatment should also be considered as part of an integrated approach. PMID:25761491

  10. Esophagectomy for failed endoscopic therapy in patients with high-grade dysplasia or intramucosal carcinoma.

    PubMed

    Hunt, B M; Louie, B E; Dunst, C M; Lipham, J C; Farivar, A S; Sharata, A; Aye, R W

    2014-01-01

    Endoscopic therapy (ablation +/- endoscopic resection) for high-grade dysplasia and/or intramucosal carcinoma (IMC) of the esophagus has demonstrated promising results. However, there is a concern that a curable, local disease may progress to systemic disease with repeated endotherapy. We performed a retrospective review of patients who underwent esophagectomy after endotherapy at three tertiary care esophageal centers from 2006 to 2012. Our objective was to document the clinical and pathologic outcomes of patients who undergo esophagectomy after failed endotherapy. Fifteen patients underwent esophagectomy after a mean of 13 months and 4.1 sessions of endotherapy for progression of disease (53%), failure to clear disease (33%), or recurrence (13%). Initially, all had Barrett's, 73% had ≥3-cm segments, 93% had a nodule or ulcer, and 91% had multifocal disease upon presentation. High-grade dysplasia was present at index endoscopy in 80% and IMC in 33%, and some patients had both. Final pathology at esophagectomy was T0 (13%), T1a (60%), T1b (20%), and T2 (7%). Positive lymph nodes were found in 20%: one patient was T2N1 and two were T1bN1. Patients with T1b, T2, or N1 disease had more IMC on index endoscopy (75% vs. 18%) and more endotherapy sessions (median 6.5 vs. 3). There have been no recurrences a mean of 20 months after esophagectomy. Clinical outcomes were comparable to other series, but submucosal invasion (27%) and node-positive disease (20%) were encountered in some patients who initially presented with a locally curable disease and eventually required esophagectomy after failed endotherapy. An initial pathology of IMC or failure to clear disease after three treatments should raise concern for loco-regional progression and prompt earlier consideration of esophagectomy. PMID:23795720

  11. ADC texture—An imaging biomarker for high-grade glioma?

    SciTech Connect

    Brynolfsson, Patrik; Hauksson, Jón; Karlsson, Mikael; Garpebring, Anders; Nyholm, Tufve; Nilsson, David; Trygg, Johan; Henriksson, Roger; Birgander, Richard; Asklund, Thomas

    2014-10-15

    Purpose: Survival for high-grade gliomas is poor, at least partly explained by intratumoral heterogeneity contributing to treatment resistance. Radiological evaluation of treatment response is in most cases limited to assessment of tumor size months after the initiation of therapy. Diffusion-weighted magnetic resonance imaging (MRI) and its estimate of the apparent diffusion coefficient (ADC) has been widely investigated, as it reflects tumor cellularity and proliferation. The aim of this study was to investigate texture analysis of ADC images in conjunction with multivariate image analysis as a means for identification of pretreatment imaging biomarkers. Methods: Twenty-three consecutive high-grade glioma patients were treated with radiotherapy (2 Gy/60 Gy) with concomitant and adjuvant temozolomide. ADC maps and T1-weighted anatomical images with and without contrast enhancement were collected prior to treatment, and (residual) tumor contrast enhancement was delineated. A gray-level co-occurrence matrix analysis was performed on the ADC maps in a cuboid encapsulating the tumor in coronal, sagittal, and transversal planes, giving a total of 60 textural descriptors for each tumor. In addition, similar examinations and analyses were performed at day 1, week 2, and week 6 into treatment. Principal component analysis (PCA) was applied to reduce dimensionality of the data, and the five largest components (scores) were used in subsequent analyses. MRI assessment three months after completion of radiochemotherapy was used for classifying tumor progression or regression. Results: The score scatter plots revealed that the first, third, and fifth components of the pretreatment examinations exhibited a pattern that strongly correlated to survival. Two groups could be identified: one with a median survival after diagnosis of 1099 days and one with 345 days, p = 0.0001. Conclusions: By combining PCA and texture analysis, ADC texture characteristics were identified, which seems

  12. Wingspan Stent for High-Grade Symptomatic Vertebrobasilar Artery Atherosclerotic Stenosis

    SciTech Connect

    Li Jian Zhao Zhenwei Gao Guodong Deng Jianping; Yu Jia; Gao Li; Yuan Yang; Qv Youzhi

    2012-04-15

    Purpose: This study was designed to present the treatment outcomes with Wingspan stent angioplasty of high-grade intracranial vertebrobasilar artery (VBA) stenosis in symptomatic patients. Methods: Between 2007 and 2010, the records of 30 patients with 31 intracranial high-grade VBA stenoses (all{>=}70%) who underwent elective stenting due to the failure of medical therapy were retrospectively reviewed. Clinical evaluation was performed based on the modified Rankin scale and the National Institutes of Health Stroke Scale. Results: In all cases, the stent deployment was technically successful. The mean stenosis decreased significantly from 82.28 {+-} 8.02% (range, 72-99%) to 11.18 {+-} 7.28% (range, 0-25%) after stent-assisted angioplasty (P < 0.05). Periprocedure complications occurred in 3 (10%) of 30 patients; there were 2 cases of perforator strokes and 1 case of transient flow insufficiency with stent overlap. Clinical follow-up (mean, 17.81 {+-} 11.49 months; range, 5-40 months) was available for 27 patients, and angiographic follow-up (mean, 9.95 {+-} 5.74 months, range, 5-20 months) was available for 19 patients. Only one case demonstrated recurrent symptoms with restenosis ({>=}50%). There were no recurrent ischemic events and no cases of restenosis in the other patients. Conclusions: According to our data, the Wingspan stent for symptomatic intracranial VBA stenoses is a safe and efficacious treatment alternative in cases with recurrent symptoms despite medical therapy. However, the improvement of outcome requires the reduction in the rate of procedure-related complications and long-term outcomes still have to be demonstrated.

  13. Simultaneous Bilateral Carotid Stenting for Symptomatic Bilateral High-Grade Carotid Stenosis: A Retrospective Clinical Investigation.

    PubMed

    Ye, Ziming; Liu, Ying; Deng, Xiao; Chen, Xiangren; Lin, Cuiting; Tang, Yanyan; Su, Ying; Fang, Lanji; Wu, Yuan; Qin, Chao

    2016-01-01

    BACKGROUND This retrospective clinical investigation aimed to evaluate the short-term effectiveness and safety of SBCAS for symptomatic bilateral high-grade CS. MATERIAL AND METHODS From 2009 to 2014, 145 patients were recruited. Among them, 70 underwent SBCAS, and other 75 patients underwent SAMM and served as controls. The immediate postprocedural complications and postprocedural neurological evaluation, as well as restenosis at 6-month and 1-year follow-ups in the SBCAS group are reported. Additionally, baseline risk factors for ischemic stroke, adverse effects of drugs, and outcomes at 30-day, 6-month, and 1-year follow-ups were compared between the 2 groups. RESULTS Our data did not reveal significant differences between the 2 groups in baseline risk factors for ischemic stroke. In the SBCAS group, both HPS (5.7%) and HD (40%) occurred, but they were not very severe, and no patients had postprocedural neurological deficit. Moreover, restenosis only occurred in 3 patients at 3 stent placement sites (4.3%) at 1-year follow-up. Adverse effects of drugs did not occur in SBCAS group, but adverse effects of Bayer aspirin and Lipitor occurred in 4 patients (5.4%) and 18 patients (24.3%), respectively, at 6-month follow-up in the control group. Furthermore, there were significant differences in outcomes between the 2 groups at 30-day, 6-month, and 1-year follow-ups, in that NIHSS, CS ratio, and incidence of endpoint events, as well as 1-year cumulative probability of endpoint events, were all lower in the SBCAS group than in the control group (p<0.05). CONCLUSIONS Compared to SAMM, we found that SBCAS was more effective and safer for symptomatic bilateral high-grade CS. PMID:27542158

  14. Surgical Treatment Strategies for High-Grade Spondylolisthesis: A Systematic Review

    PubMed Central

    Poorman, Caroline E.; Yang, Sun; Boniello, Anthony J.; Jalai, Cyrus M.; Worley, Nancy; Lafage, Virginie

    2015-01-01

    Background HGS is a severe deformity most commonly affecting L5-S1 vertebral segment. Treatment available for HGS includes a range of different surgical options: full or partial reduction of translation and/or abnormal alignment and in situ fusion with or without decompression. Various instrumented or non-instrumented constructs are available, and surgical approach varies from anterior/posterior to combined depending on surgeon preference and experience. The aim of this systematic review was to review the literature on lumbosacral high-grade spondylolisthesis (HGS), identify patients at risk for progression to higher-grade slip and evaluate various surgical strategies to report on complications and radiographic and clinical outcomes. Methods Systematic search of PubMed, Cochrane and Google Scholar for papers relevant to HGS was performed. 19 articles were included after title, abstract, and full-text review and grouped to analyze baseline radiographic parameters and the effect of surgical approach, instrumentation, reduction and decompression on patient radiographic and clinical outcomes. Results There is a lack of high-quality studies pertaining to surgical treatment for HGS, and a majority of included papers were Level III or IV based on the JBJS Levels of Evidence Criteria. Conclusions Surgical treatment for HGS can vary depending on patient age. There is strong evidence of an association between increased pelvic incidence (PI) and presence of HGS and moderately strong evidence that patients with unbalanced pelvis can benefit from correction of lumbopelvic parameters with partial reduction. Surgeons need to weigh the benefits of fixing the deformity with the risks of potential complications, assessing patient satisfaction as well as their understanding of the possible complications. However, further research is necessary to make more definitive conclusions on surgical treatment guidelines for HGS. Level of Evidence II PMID:26512344

  15. Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node.

    PubMed

    Ducharne-Asuaje, Eugenia; Dorion, Dominique; Lamarre, Louis; Coindre, Jean Michel; Geha, Sameh

    2016-06-01

    Head and neck angiosarcoma is an infrequent malignant vascular tumor most commonly found in the skin and soft tissue of the head and neck. Most head and neck angiosarcomas are metastatic to cervical lymph nodes from other primitive location. We describe herein a case of primary high-grade poorly differentiated angiosarcoma arising in an intra-parotid lymph node, discuss the value of immunohistochemical stains for differential diagnosis, and review the literature concerning head and neck angiosarcoma. A 47-year-old man presented with a painless mass that had grown for a period of 6 months in the parotid area. The CT-scan revealed a left parotid lesion of 17 mm. Fine needle aspiration was considered suspicious for lymphoma or poorly differentiated carcinoma. A superficial parotidectomy was performed. On gross examination, the lesion was a well-defined, gray, homogeneous mass of 15 mm of diameter. Microscopic examination showed a normal parotid tissue and a poorly differentiated malignant neoplasm in an intra-parotid lymph node. The tumor had a pseudo-alveolar pattern, with large pleomorphic epithelioid cells, abundant eosinophilic cytoplasm, large vesicular nuclei, and one or more prominent nucleoli. Atypical mitoses were seen. Neoplastic malignant cells stained positive for Vimentin, CD31, D2-40, factor VIII, ERG, and partially for CD34. A positron emission tomography scan was made to search for a primary neoplasia, but no other tumor was localized. The diagnosis of primary high-grade, poorly differentiated, intra-parotid lymph node angiosarcoma was established. PMID:25930154

  16. PAR1 is selectively over expressed in high grade breast cancer patients: a cohort study

    PubMed Central

    Hernández, Norma A; Correa, Elma; Avila, Esther P; Vela, Teresa A; Pérez, Víctor M

    2009-01-01

    Background The protease-activated receptor (PAR1) expression is correlated with the degree of invasiveness in cell lines. Nevertheless it has never been directed involved in breast cancer patients progression. The aim of this study was to determine whether PAR1 expression could be used as predictor of metastases and mortality. Methods In a cohort of patients with infiltrating ductal carcinoma studied longitudinally since 1996 and until 2007, PAR1 over-expression was assessed by immunoblotting, immunohistochemistry, and flow citometry. Chi-square and log rank tests were used to determine whether there was a statistical association between PAR1 overexpression and metastases, mortality, and survival. Multivariate analysis was performed including HER1, stage, ER and nodes status to evaluate PAR1 as an independent prognostic factor. Results Follow up was 95 months (range: 2–130 months). We assayed PAR1 in a cohort of patients composed of 136 patients; we found PAR1 expression assayed by immunoblotting was selectively associated with high grade patients (50 cases of the study cohort; P = 0.001). Twenty-nine of 50 (58%) patients overexpressed PAR1, and 23 of these (46%) developed metastases. HER1, stage, ER and PAR1 overexpression were robustly correlated (Cox regression, P = 0.002, P = 0.024 and P = 0.002 respectively). Twenty-one of the 50 patients (42%) expressed both receptors (PAR1 and HER1 P = 0.0004). We also found a statistically significant correlation between PAR1 overexpression and increased mortality (P = 0.0001) and development of metastases (P = 0.0009). Conclusion Our data suggest PAR1 overexpression may be involved in the development of metastases in breast cancer patient and is associated with undifferentiated cellular progression of the tumor. Further studies are needed to understand PAR1 mechanism of action and in a near future assay its potential use as risk factor for metastasis development in high grade breast cancer patients. PMID:19538737

  17. The PapilloCheck Assay for Detection of High-Grade Cervical Intraepithelial Neoplasia.

    PubMed

    Crosbie, Emma J; Bailey, Andrew; Sargent, Alex; Gilham, Clare; Peto, Julian; Kitchener, Henry C

    2015-11-01

    Human papillomavirus (HPV) testing is used in primary cervical screening, as an adjunct to cervical cytology for the management of low grade abnormal cytology, and in a test of cure. PapilloCheck (Greiner Bio-One) is a PCR-based DNA microarray system that can individually identify 24 HPV types, including the 13 high-risk (HR) types identified by Hybrid Capture 2 (HC2). Here, we compare PapilloCheck with HC2 for the detection of high-grade cervical intraepithelial neoplasia (CIN2+) in a total of 8,610 cervical cytology samples from the ARTISTIC population-based cervical screening study. We performed a retrospective analysis of 3,518 cytology samples from round 1 ARTISTIC enriched for underlying CIN2+ (n = 723) and a prospective analysis of 5,092 samples from round 3 ARTISTIC. Discrepant results were tested using the Roche reverse line blot (RLB) or Linear Array (LA) assay. The relative sensitivity and specificity of HR PapilloCheck compared with that of HC2 for the detection of CIN2+ in women aged over 30 years were 0.94 (95% confidence interval [CI], 0.91, 0.97) and 1.05 (95% CI, 1.04, 1.05), respectively. HC2 missed 44/672 (7%) CIN2+ lesions, while HR PapilloCheck missed 74/672 (11%) CIN2+ lesions. Thirty-six percent of HC2-positive normal cytology samples were HR HPV negative by both PapilloCheck and RLB/LA, indicating that the use of HR PapilloCheck rather than HC2 in population-based primary screening would reduce the number of additional tests required (e.g., reflex cytology) in women where underlying CIN2+ is extremely unlikely. HR PapilloCheck could be a suitable HPV detection assay for use in the cervical screening setting. PMID:26338859

  18. Surgical Versus Nonsurgical Treatment for High-Grade Spondylolisthesis in Children and Adolescents

    PubMed Central

    Xue, Xuhong; Wei, Xiaochun; Li, Li

    2016-01-01

    Abstract The optimal management of high-grade spondylolisthesis in children and adolescent is controversial. There is a paucity of literature regarding operatively or nonoperative management in this setting. To assessment of the current state of evidence regarding high-grade spondylolisthesis treatment with the goal of obtaining outcome comparisons in these patients managed either operatively or nonoperatively. We performed a systematic literature search up to November 2014, using Medline, Embase, and The Cochrane Library. The analysis and eligibility criteria were documented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-guidelines) and Cochrane Back Review Group editorial board. We used the Newcastle–Ottawa quality assessment scale (NOS-scale) to assess the quality. Five observational studies were considered eligible for analysis based on the evaluation of 1596 identified papers. The mean overall difference in the Scoliosis Research Society questionnaire 22 between the surgical and nonsurgical groups was not statistically significant (95% CI: −0.17 to 0.21, P = 0.84). The pooled mean difference in progression of slip between the surgical and nonsurgical groups was no significant difference (OR: 0.47, 95% CI: 0.12–1.81, P = 0.27, I2 = 0%). Because of the preponderance of uncontrolled case series, low-quality evidence indicates that the quality of life and progression of slips was no significant difference between surgery and nonoperation group. Nonoperative patients had no radiologic progression of their slip during the follow-up period. PMID:26986134

  19. Simultaneous Bilateral Carotid Stenting for Symptomatic Bilateral High-Grade Carotid Stenosis: A Retrospective Clinical Investigation

    PubMed Central

    Ye, Ziming; Liu, Ying; Deng, Xiao; Chen, Xiangren; Lin, Cuiting; Tang, Yanyan; Su, Ying; Fang, Lanji; Wu, Yuan; Qin, Chao

    2016-01-01

    Background This retrospective clinical investigation aimed to evaluate the short-term effectiveness and safety of SBCAS for symptomatic bilateral high-grade CS. Material/Methods From 2009 to 2014, 145 patients were recruited. Among them, 70 underwent SBCAS, and other 75 patients underwent SAMM and served as controls. The immediate postprocedural complications and postprocedural neurological evaluation, as well as restenosis at 6-month and 1-year follow-ups in the SBCAS group are reported. Additionally, baseline risk factors for ischemic stroke, adverse effects of drugs, and outcomes at 30-day, 6-month, and 1-year follow-ups were compared between the 2 groups. Results Our data did not reveal significant differences between the 2 groups in baseline risk factors for ischemic stroke. In the SBCAS group, both HPS (5.7%) and HD (40%) occurred, but they were not very severe, and no patients had postprocedural neurological deficit. Moreover, restenosis only occurred in 3 patients at 3 stent placement sites (4.3%) at 1-year follow-up. Adverse effects of drugs did not occur in SBCAS group, but adverse effects of Bayer aspirin and Lipitor occurred in 4 patients (5.4%) and 18 patients (24.3%), respectively, at 6-month follow-up in the control group. Furthermore, there were significant differences in outcomes between the 2 groups at 30-day, 6-month, and 1-year follow-ups, in that NIHSS, CS ratio, and incidence of endpoint events, as well as 1-year cumulative probability of endpoint events, were all lower in the SBCAS group than in the control group (p<0.05). Conclusions Compared to SAMM, we found that SBCAS was more effective and safer for symptomatic bilateral high-grade CS. PMID:27542158

  20. Preparation of High-Grade Powders from Tomato Paste Using a Vacuum Foam Drying Method.

    PubMed

    Sramek, Martin; Schweiggert, Ralf Martin; van Kampen, Andreas; Carle, Reinhold; Kohlus, Reinhard

    2015-08-01

    We present a rapid and gentle drying method for the production of high-grade tomato powders from double concentrated tomato paste, comparing results with powders obtained by foam mat air drying and freeze dried powders. The principle of this method consists of drying tomato paste in foamed state at low temperatures in vacuum. The formulations were dried at temperatures of 50, 60, and 70 °C and vacuum of 200 mbar. Foam stability was affected by low serum viscosity and the presence of solid particles in tomato paste. Consequently, serum viscosity was increased by maltodextrin addition, yielding optimum stability at tomato paste:maltodextrin ratio of 2.4:1 (w/w) in dry matter. Material foamability was improved by addition of 0.5% (w/w, fresh weight) egg white. Because of solid particles in tomato paste, foam air filling had to be limited to critical air volume fraction of Φ = 0.7. The paste was first pre-foamed to Φ = 0.2 and subsequently expanded in vacuo. After drying to a moisture content of 5.6% to 7.5% wet base (w.b.), the materials obtained were in glassy state. Qualities of the resulting powders were compared with those produced by freeze and air drying. Total color changes were the least after vacuum drying, whereas air drying resulted in noticeable color changes. Vacuum foam drying at 50 °C led to insignificant carotenoid losses, being equivalent to the time-consuming freeze drying method. In contrast, air drying caused lycopene and β-carotene losses of 18% to 33% and 14% to 19% respectively. Thus, vacuum foam drying enables production of high-grade tomato powders being qualitatively similar to powders obtained by freeze drying. PMID:26189747

  1. Metal recovery from high-grade WEEE: a life cycle assessment.

    PubMed

    Bigum, Marianne; Brogaard, Line; Christensen, Thomas H

    2012-03-15

    Based on available data in the literature the recovery of aluminium, copper, gold, iron, nickel, palladium and silver from high-grade WEEE was modeled by LCA. The pre-treatment of WEEE included manual sorting, shredding, magnetic sorting, Eddy-current sorting, air classification and optical sorting. The modeled metallurgical treatment facility included a Kaldo plant, a converter aisle, an anode refinery and a precious metal refinery. The metallurgic treatment showed significant environmental savings when credited the environmental load from avoided production of the same amount of metals by mining and refining of ore. The resource recovery per tonne of high-grade WEEE ranged from 2g of palladium to 386kg of iron. Quantified in terms of person-equivalents the recovery of palladium, gold, silver, nickel and copper constituted the major environmental benefit of the recovery of metals from WEEE. These benefits are most likely underestimated in the model, since we did not find adequate data to include all the burdens from mining and refining of ore; burdens that are avoided when metals are recovered from WEEE. The processes connected to the pre-treatment of WEEE were found to have little environmental effect compared to the metallurgical treatment. However only 12-26% of silver, gold and palladium are recovered during pre-treatment, which suggest that the reduction of the apparent losses of precious metals as palladium, gold and silver during pre-treatment of WEEE is of environmental importance. Our results support in a quantitative manner that metal recovery from WEEE should be quantified with respect to the individual metals recovered and not as a bulk metal recovery rate. PMID:22115841

  2. A modified Bohlman technique using a novel implant for treatment of high-grade spondylolisthesis.

    PubMed

    Hire, Justin M; Jacobs, Jeremy M; Bundy, Justin V; DeVine, John G

    2015-01-01

    Several surgical options for managing high-grade spondylolisthesis have been described in the literature and range from posterior-only in situ fusion to circumferential fusion with complete reduction of the dislocation. The level of evidence supporting any one technique is weak, and to date there is no Level I or II evidence supporting any current surgical treatment option. Techniques have evolved as implant technology has advanced and surgeons have gained experience with deformity correction. Still, the paucity of cases at any one institution limits the ability to perform clinical studies in a prospective and randomized fashion. To the authors' knowledge, the use of the AxiaLif bolt in a modified Bohlman technique has not been described. In the setting of a case of symptomatic high-grade spondylolisthesis refractory to nonoperative management, the authors describe a modified Bohlman technique in which they used the AxiaLif bolt rather than the fibula graft that was originally described. They then supplemented this with pedicle screw instrumentation and an iliac crest autograft. At the 2-year follow-up exam, the patient exhibited relief of his preoperative back and leg pain and he had returned to all activities. The latest radiographs demonstrated successful fusion. A single-stage, posterior instrumented fusion in which the AxiaLif bolt is used in lieu of fibula autograft or allograft in a modified Bohlman technique is technically less demanding, does not have the morbidity associated with harvesting a fibula autograft, and carries no risk of disease transmission associated with the use of allograft. PMID:25380540

  3. A high efficiency bulk graded band gap/PN junction solar cell structure at high concentration ratios

    SciTech Connect

    Borrego, J.M.; Gandhi, S.K.; Page, D.A.

    1984-05-01

    This paper presents an analysis of a solar cell structure for achieving high efficiency at high concentration ratios. The structure consists of a bulk graded band gap P region followed by a PN junction at the smaller band gap side. The advantage of this structure is that the open circuit voltage is determined by the value of the higher band gap and the short circuit current by the lower band gap. A structure with E /SUB G1/ = 2.0 eV and E /SUB G2/ = 0.7 eV has an estimated efficiency of 45% at 1000 suns. Material systems which can be used for the realization of this structure are briefly described.

  4. The Impact of Seat belts and Airbags on High Grade Renal Injuries and Nephrectomy Rates in Motor Vehicle Collisions

    PubMed Central

    Bjurlin, Marc A; Fantus, Richard J.; Mellett, Michele M.; Fantus, Richard J.; Villines, Dana

    2015-01-01

    Purpose Motor vehicle collisions (MVCs) are the most common cause of blunt genitourinary trauma. We compared renal injuries with no protective device to those with seat belts and/or airbags utilizing the National Trauma Data Bank (NTDB). Our primary endpoint was a reduction in high-grade renal injuries (grades III-V) with a secondary endpoint of reduction in nephrectomy rate. Materials and Methods The NTDB research datasets, admission year 2010, 2011, and 2012, were queried for MVC occupants with renal injury. Subjects were stratified by protective device and airbag deployment. Abbreviated Injury Score was converted to American Association for the Surgery of Trauma renal injury grade and nephrectomy rates were evaluated. Intergroup comparisons were analyzed for renal injury grades, nephrectomy, length of stay, and mortality with chi-square or one-way ANOVA. Protective device relative risk reduction was determined. Results A review of 466,028 MVCs revealed 3,846 renal injuries. Injured occupants without a protective device had a higher rate of high grade renal injury (45.1%) compared to those with seat belts (39.9%, p=0.008), airbags (42.3%, p=0.317), and seat belts with airbags (34.7%, p<0.001). Seat belts (20.0%, p<0.001), airbags (10.5% p<0.001), and seat belts with airbags (13.3%, p<0.001) reduced the rate of nephrectomy compared to no protective device (56.2%). The combination of seatbelts and airbags also reduced total hospital length of stay (p<0.001) and ICU days (p=0.005). Relative risk reduction of high-grade renal injuries (23.1%) and nephrectomy (39.9%) were highest for combined protective devices. Conclusions Occupants of MVCs with protective devices have reduced rates of high-grade renal injury and nephrectomy. Reduction appears most pronounced with the combination of seat belts and airbags. PMID:24846798

  5. Consuming Educational Services: A Curriculum Module for Eleventh Grade Students in the State of New York.

    ERIC Educational Resources Information Center

    Fischer, Louis; Schimmel, David

    The document presents a curriculum module designed to help 11th grade students become intelligent consumers of educational services by focusing on relevant contemporary legal developments. The major goal is to promote students' awareness and understanding of their role as consumers of educational services, their rights and obligations, legal…

  6. The Vietnam War: A Four Week Instructional Unit. Grades 11-12.

    ERIC Educational Resources Information Center

    Meadows, Darrell

    This 4-week curriculum is designed to help 11th and 12th grade students reach an understanding of the history and culture of Vietnam and the roots of U.S. military involvement there, and also to draw lessons from U.S. actions during the war in Vietnam. Students are encouraged to engage in critical thinking, evaluation, drawing conclusions, taking…

  7. EDITORIAL: Special issue containing papers presented at the 11th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems Special issue containing papers presented at the 11th IAEA Technical Meeting on Energetic Particles in Magnetic Confinement Systems

    NASA Astrophysics Data System (ADS)

    Kolesnichenko, Ya.

    2010-08-01

    topics, which were also covered at previous conferences in this series and have become conventional, experimental and theoretical results on the influence of energetic ions on bulk plasma transport properties were also reported. Some materials from the meeting are available on the web page http://www.kinr.kiev.ua/TCM/index.html. 24 of the works presented at the meeting are published in this special issue. These works were reviewed to the usual high standard of Nuclear Fusion. The guest editor of this special issue is grateful to the publishers for their cooperation.

  8. Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus.

    PubMed

    Pautier, Patricia; Nam, Eun Ji; Provencher, Diane M; Hamilton, Anne L; Mangili, Giorgia; Siddiqui, Nadeem Ahmad; Westermann, Anneke M; Reed, Nicholas Simon; Harter, Philipp; Ray-Coquard, Isabelle

    2014-11-01

    High-grade undifferentiated sarcomas (HGUSs) are rare uterine malignancies arising from the endometrial stroma. They are poorly differentiated sarcomas composed of cells that do not resemble proliferative-phase endometrial stroma. High-grade undifferentiated sarcomas are characterized by aggressive behavior and poor prognosis. Cyclin D1 has been reported as a diagnostic immunomarker for high-grade endometrial stromal sarcoma with an YWHAE-FAM22 rearrangement. YWHAE-FAM22 endometrial stromal sarcomas (ESS) represent a clinically aggressive subtype of ESS classified as high-grade endometrial sarcomas, and its distinction from the usual low-grade ESS with JAZF1 rearrangement and from HGUS with no identifiable molecular aberration may be important in guiding clinical management. Median age of the patients is between 55 and 60 years. The most common symptoms are vaginal bleeding, abdominal pain, and increasing abdominal girth.Disease is usually advanced with approximately 70% of the patients staged III to IV according to the International Federation of Gynecology and Obstetrics classification. Preferential metastatic locations include peritoneum, lungs, intra-abdominal lymph nodes, and bone. Median progression-free survival ranged from 7 to 10 months, and median overall survival ranged from 11 to 23 months. There is no clear prognostic factor identified for HGUS, not even stage. The standard management for HGUS consists of total hysterectomy and bilateral salpingo-oophorectomy. Systematic lymphadenectomy is not recommended. Adjuvant therapies, such as chemotherapy and radiotherapy, have to be discussed in multidisciplinary staff meetings. PMID:25341584

  9. Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

    PubMed

    Zhang, Keqiang; Chu, Kevin; Wu, Xiwei; Gao, Hanlin; Wang, Jinhui; Yuan, Yate-Ching; Loera, Sofia; Ho, Kimberley; Wang, Yafan; Chow, Warren; Un, Frank; Chu, Peiguo; Yen, Yun

    2013-02-15

    Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first comparatively examined the amplification and expression of FRS2 with CDK4 and MDM2 in dedifferentiated liposarcoma (DDLS) and undifferentiated high-grade pleomorphic sarcoma (UHGPS). Amplification and expression of the three genes were identified in 90% to 100% (9-11 of 11) of DDLS, whereas that of FRS2, CDK4, and MDM2 were observed in 55% (41 of 75), 48% (36 of 75), and 44% (33/75) of clinically diagnosed UHGPS, suggesting that these "UHGPS" may represent DDLS despite lacking histologic evidence of lipoblasts. Immunohistochemical analysis of phosphorylated FRS2 protein indicated that the FGFR/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas. Moreover, we found that FRS2 and FGFRs proteins are highly expressed and functional in three high-grade liposarcoma cell lines: FU-DDLS-1, LiSa-2, and SW872. Importantly, the FGFR selective inhibitor NVP-BGJ-398 significantly inhibited the growth of FU-DDLS-1 and LiSa-2 cells with a concomitant suppression of FGFR signal transduction. Attenuation of FRS2 protein in FU-DDLS-1 and LiSa-2 cell lines decreased the phosphorylated extracellular signal-regulated kinase 1/2 and AKT and repressed cell proliferation. These findings indicate that analysis of FRS2 in combination with CDK4 and MDM2 will more accurately characterize pathologic features of high-grade liposarcomas. Activated FGFR/FRS2 signaling may play a functional role in the development of high-grade liposarcomas, therefore, serve as a potential therapeutic target. PMID:23393200

  10. The Weaknesses and Shortcomings of the Junior High School in Israel: Some Insights into Grade Configurations of Educational Systems

    ERIC Educational Resources Information Center

    Oplatka, Izhar; Tubin, Dorit

    2009-01-01

    The current study aimed to explore the weaknesses of the junior high school system in Israel, a country whose first junior high schools (Grades 7-9) were established in the early 1970s and whose educational system differs from the systems of Europe and North America in terms of structure, ideology, and control. Based on semistructured interviews…

  11. College Performance and Retention: A Meta-Analysis of the Predictive Validities of ACT® Scores, High School Grades, and SES

    ERIC Educational Resources Information Center

    Westrick, Paul A.; Le, Huy; Robbins, Steven B.; Radunzel, Justine M. R.; Schmidt, Frank L.

    2015-01-01

    This meta-analysis examines the strength of the relationships of ACT® Composite scores, high school grades, and socioeconomic status (SES) with academic performance and persistence into the 2nd and 3rd years at 4-year colleges and universities. Based upon a sample of 189,612 students at 50 institutions, ACT Composite scores and high school grade…

  12. A Support Program for At-Risk Ninth Graders: Evaluation of the Ninth Grade Project at Denby High School.

    ERIC Educational Resources Information Center

    Syropoulow, Mike

    1996-01-01

    Discusses research on successful support programs for potential dropouts. Describes a Detroit high school's Ninth Grade Project 96 program, an intervention strategy for high-risk, low-achieving students. The program used a modified block schedule; attendance, academic, and monitoring interventions; incentives and rewards; and team teachers.…

  13. Grade 12 Student Career Needs and Perceptions of the Effectiveness of Career Development Services within High Schools

    ERIC Educational Resources Information Center

    Bloxom, Joan M.; Bernes, Kerry B.; Magnusson, Kris C.; Gunn, Thelma T.; Bardick, Angela D.; Orr, David T.; McKnight, Kerbi M.

    2008-01-01

    High school students engaging in career decision making encounter significant challenges due to changing social and economic conditions. The student needs assessment focus of this study provides unique insights into student perceptions of the effectiveness of high school career programs. Results indicated that Grade 12 students value resources…

  14. The Consistency between Human Raters and an Automated Essay Scoring System in Grading High School Students' English Writing

    ERIC Educational Resources Information Center

    Tsai, Min-hsiu

    2012-01-01

    This study investigates the consistency between human raters and an automated essay scoring system in grading high school students' English compositions. A total of 923 essays from 23 classes of 12 senior high schools in Taiwan (Republic of China) were obtained and scored manually and electronically. The results show that the consistency between…

  15. The Relationship between High School Course Grades and Exam Scores. Research Watch. E&R Report No. 09.39

    ERIC Educational Resources Information Center

    Boykin, Anne-Sylvie M.

    2010-01-01

    Since the 2006-07 school year, in addition to earning a certain number of course credits, all North Carolina high school students have been required to pass the End of Course test (EOC) in five subjects in order to obtain a high school diploma. This report examines the relationship between EOC test results and course grades for Algebra I and…

  16. Professional Staffing Levels and Fourth-Grade Student Research in Rural Schools with High-Poverty Levels

    ERIC Educational Resources Information Center

    Krueger, Karla Steege; Donham, Jean

    2013-01-01

    Rural schools in high-poverty areas are often understaffed. This descriptive phenomenological study examined fourth-grade state research projects in high-poverty rural Iowa schools to reveal the influence of school librarians' staffing levels on student learning of research skills. To determine evidence of students' critical literacy, ethical use…

  17. Using multiple chemical systems in zircon to unravel the evolution of high-grade terranes

    NASA Astrophysics Data System (ADS)

    Clark, Chris; Taylor, Richard

    2016-04-01

    Since the turn of the century the rare earth element (REE) partitioning between zircon and garnet has facilitated the coupling of U-Pb ages to metamorphism, particularly in the granulite facies. The combination of in situ analysis and rapid data acquisition, particularly through combined techniques such as Laser Ablation Split Stream (LASS), means that complex terranes can be interrogated with increasing detail. However this detail provided by large datasets must also be combined with an understanding of the processes involved, for example the relative mobility of the REE and U-Pb systems with zircon grains that have withstood intense P-T conditions to varying degrees. For example, some high-temperature metapelites that seem to have all the right ingredients for the "equilibrium" to be achieved (e.g. they contain garnet, zircon, monazite and rutile, they've melted and experienced temperatures in excess of 900 °C) display variations in the REE partitioning between zircon and garnet that varies over the length-scale of a single thin section. This presentation seeks to highlight some complexities in the application of these undoublty useful techniques to high-temperature metamorphic rocks from a number of terranes and hopefully provide some useful comments on developing more efficient strategies to characterise the P-T-t evolution of high-grade terranes.

  18. High Efficiency Tandem Thin-Perovskite/Polymer Solar Cells with a Graded Recombination Layer.

    PubMed

    Liu, Yao; Renna, Lawrence A; Bag, Monojit; Page, Zachariah A; Kim, Paul; Choi, Jaewon; Emrick, Todd; Venkataraman, D; Russell, Thomas P

    2016-03-23

    Perovskite-containing tandem solar cells are attracting attention for their potential to achieve high efficiencies. We demonstrate a series connection of a ∼90 nm thick perovskite front subcell and a ∼100 nm thick polymer:fullerene blend back subcell that benefits from an efficient graded recombination layer containing a zwitterionic fullerene, silver (Ag), and molybdenum trioxide (MoO3). This methodology eliminates the adverse effects of thermal annealing or chemical treatment that occurs during perovskite fabrication on polymer-based front subcells. The record tandem perovskite/polymer solar cell efficiency of 16.0%, with low hysteresis, is 75% greater than that of the corresponding ∼90 nm thick perovskite single-junction device and 65% greater than that of the polymer single-junction device. The high efficiency of this hybrid tandem device, achieved using only a ∼90 nm thick perovskite layer, provides an opportunity to substantially reduce the lead content in the device, while maintaining the high performance derived from perovskites. PMID:26918708

  19. High-Temperature Refining of Metallurgical-Grade Silicon: A Review

    NASA Astrophysics Data System (ADS)

    Johnston, Murray D.; Khajavi, Leili Tafaghodi; Li, Mark; Sokhanvaran, Samira; Barati, Mansoor

    2012-08-01

    Among currently known alternatives for renewable energy sources, solar power is generally regarded as having the most potential to satisfy the ever-growing demand. While solar photovoltaic power is a well-established technology, its widespread uptake has been hindered by the prohibitively high price of units and thus electricity. This is due mainly to the high cost of the silicon used to fabricate the devices. This article presents a review of the development of established pyrometallurgical techniques as applied to refining metallurgical silicon to solar grade for the purposes of reducing reliance on expensive traditional silicon feedstock. Four basic high-temperature methods—solvent refining, vaporization, electrorefining, and slag treatment—are described, and the limitations and advantages of each method are presented. It is apparent that these techniques are very useful for removing impurities from silicon, but are often selective and not able to remove all problematic elements. Therefore, refining may need to be as a sequence of steps, targeting specific elements each time, or as novel methods combining multiple techniques simultaneously. Ultimately, the successful approach will have to achieve large-scale production by cost-effective means to replace current methods.

  20. Elevated Serum MicroRNA Levels Associate with Absence of High-Grade Prostate Cancer in a Retrospective Cohort

    PubMed Central

    Mihelich, Brittany L.; Maranville, Joseph C.; Nolley, Rosalie; Peehl, Donna M.; Nonn, Larisa

    2015-01-01

    To reduce treatment of indolent prostate cancer (PCa), biomarkers are needed to improve identification of patients with a low-risk of having aggressive disease. Over-treatment of these patients occurs because of uncertainty in the aggressiveness of the entire tumor based on the biopsies, which do not accurately sample multifocal tumors. Circulating microRNAs (miRNAs) are stable serum markers and differential miRNA levels occur in men with PCa. The goal of this study was to identify circulating miRNAs that were associated with aggressive or indolent PCa. We measured circulating miRNAs in 150 patients prior to surgery and compared the miRNA levels to the pathology of the entire radical prostatectomy specimen. For this study we used an exceptionally well-characterized cohort of patients who had benign prostatic hyperplasia (BPH), low-grade or high-grade PCa. Low-grade was defined as patients with 100% Gleason grade 3 tumor as determined by step-wise sectioning. High-grade PCa patients had 30-90% Gleason grade 4+5 in the tumor. BPH patients had at least two biopsies negative for PCa. Twenty one miRNAs were selected for analysis. The miRNAs were quantified by RT-qPCR and analyzed by logistic regression. High levels of 14 miRNAs were exclusively present in the serum from patients with low-grade PCa or BPH, compared to men with high-grade PCa who had consistently low levels. The expression levels of the 14 miRNAs were combined into a “miR Score” which had a negative predictive value (NPV) of 0.939 to predict absence of high-grade PCa among PCa and BPH patients. Biochemical recurrence (BCR) was known for the PCa patients and a combined “miR Risk Score” accurately classified a subset of patients with low risk of BCR (NPV 0.941). In summary, measurement of serum miRNAs may have pre-surgical utility in combination with clinical risk calculators to identify patients with low risk of harboring aggressive PCa. PMID:25874774

  1. Predictive Value of Cytokeratin 7 Immunohistochemistry in Cervical Low-grade Squamous Intraepithelial Lesion as a Marker for Risk of Progression to a High-grade Lesion.

    PubMed

    Paquette, Cherie; Mills, Anne M; Stoler, Mark H

    2016-02-01

    The squamocolumnar junction (SCJ) cell population of the uterine cervix is a discrete epithelial area and the putative source of the majority of high-grade squamous intraepithelial lesions (HSIL). The SCJ cells can be identified by immunohistochemical (IHC) stains including cytokeratin 7 (CK7). Others have theorized that an SCJ marker-positive low-grade squamous intraepithelial lesion (LSIL) has a higher risk for future HSIL compared with an SCJ marker-negative LSIL. This study has 2 aims: first, to refine the definition of a positive CK7 immunostaining pattern in cervical lesions, and, second, to test the hypothesis that CK7 positivity in LSIL indicates higher risk for future HSIL, with both questions addressed using a data set with consensus diagnoses. One hundred cases each of LSIL, moderate HSIL (CIN2), and severe HSIL (CIN3) were stained for CK7, with positivity defined as a diffuse cytoplasmic staining pattern (>5 to 6 contiguous cells); all others were considered negative. Using this model, 34% of CIN1, 45% of CIN2, and 60% of CIN3 were CK7 positive. With follow-up, CK7-positive LSILs were more likely to progress to HSIL compared with CK7-negative LSIL (32% vs. 11%, P=0.05), in concordance with the results of other researchers. This study simplifies cervical CK7 IHC grading into a reproducible system and supports the thesis that CK7 positivity in LSIL is associated with increased risk for future HSIL. Larger cohorts using consensus-diagnosed LSIL are needed to confirm these results before CK7 may be considered for clinical validation. PMID:26551618

  2. Curriculum Guide in Reading. Developmental Reading: Junior and Senior High Schools, Grades 7-12.

    ERIC Educational Resources Information Center

    Hand, John, Ed.; And Others

    GRADES OR AGES: Grades 7-12. SUBJECT MATTER: Developmental reading. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into nine short chapters and several appendixes. It is offset printed and edition bound with a paper cover. OBJECTIVES AND ACTIVITIES: No objectives are mentioned. General guidelines are given for planning activities to…

  3. Implications of Eighth Grade Algebra I on High School Mathematics Achievement

    ERIC Educational Resources Information Center

    Bayard, Robert

    2012-01-01

    As of 2008, approximately 40% of eighth grade students in the United States enroll in Algebra I (National Council of Teachers of Mathematics, 2008). Although research has shown that students have more opportunities to take advanced mathematics courses by taking eighth grade Algebra I, in the United States, approximately only one-third to one-half…

  4. The Association between Standards- Based Grading and Standardized Test Scores in a High School Reform Model

    ERIC Educational Resources Information Center

    Pollio, Marty; Hochbein, Craig

    2015-01-01

    Background/Context: From two decades of research on the grading practices of teachers in secondary schools, researchers discovered that teachers evaluated students on numerous factors that do not validly assess a student's achievement level in a specific content area. These consistent findings suggested that traditional grading practices evolved…

  5. 5 Key Findings for Middle Grades from "Looking Forward to High School and College"

    ERIC Educational Resources Information Center

    Allensworth, Elaine M.; Gwynne, Julia A.; Moore, Paul; de La Torre, Marisa

    2014-01-01

    Preparation for college and careers begins when students are young, yet, it can be difficult for middle grade educators to know how best to prepare these students for future success. Middle grade practitioners need to know what to pay attention to and who needs additional support. Without knowing how to identify students who are on-track for high…

  6. High-grade Neuroendocrine Carcinoma With Focal Squamous Metaplasia of Renal Pelvis Associated With Renal Calculus: Study of a Case

    PubMed Central

    Huang, Yan-Ping; Chen, Bin; Sun, Xiang-Zhou; Guo, Yan; Yang, Shi-Cong; Deng, Chun-Hua; Huang, Yi-Ran

    2014-01-01

    Mixed neuroendocrine and non-neuroendocrine type of tumor in renal pelvis is rare and presents a high-grade malignancy. We present a case report that a 57-year-old man had no history of small cell cancer but presented a high-grade neuroendocrine carcinoma with focal squamous metaplasia and multiple stones simultaneously in the right renal pelvis. The patient underwent nephroureterocystectomy 9 months before this presentation, with evidence of multiple metastatic tumors in various parts of the body. The case of mixed neuroendocrine tumor with stones in the renal pelvis carries a poor prognosis and poses a therapeutic challenge to urologists. PMID:26952913

  7. Geophysical evidences for a thick crust south of Palghat-Tiruchi gap in the High Grade Terrains of South India

    NASA Technical Reports Server (NTRS)

    Mishra, D. C.

    1988-01-01

    The regional gravity and magnetic features of the South Indian Shield were discussed. The prominent regional gravity low of 20 to 30 mgls over the charnockite terrain of South India, coupled with the correlation of a steep gravity gradient with a prominent shear zone to the north, can be interpreted in terms of increased crustal thickness in the South Indian high-grade terrain. There is some support for this from deep seismic sounding. The magnetic signature of the high-grade terrain is also distinctive, and Mishra argued that the Palghat-Tiruchi line might represent a Precambrian boundary such as a suture between two distinct crustal blocks.

  8. Zircon response to high-grade metamorphism as revealed by U-Pb and cathodoluminescence studies

    NASA Astrophysics Data System (ADS)

    Siebel, W.; Shang, C. K.; Thern, E.; Danišík, M.; Rohrmüller, J.

    2012-11-01

    Correct interpretation of zircon ages from high-grade metamorphic terrains poses a major challenge because of the differential response of the U-Pb system to metamorphism, and many aspects like pressure-temperature conditions, metamorphic mineral transformations and textural properties of the zircon crystals have to be explored. A large (c. 450 km2) coherent migmatite complex was recently discovered in the Bohemian Massif, Central European Variscides. Rocks from this complex are characterized by granulite- and amphibolite-facies mineral assemblages and, based on compositional and isotopic trends, are identified as the remnants of a magma body derived from mixing between tonalite and supracrustal rocks. Zircon crystals from the migmatites are exclusively large (200-400 μm) and yield 207Pb/206Pb evaporation ages between 342-328 Ma and single-grain zircon fractions analysed by U-Pb ID-TIMS method plot along the concordia curve between 342 and 325 Ma. High-resolution U-Pb SHRIMP analyses substantiate the existence of a resolvable age variability and yield older 206Pb/238U ages (342-330 Ma, weighted mean age = 333.6 ± 3.1 Ma) for inner zone domains without relict cores and younger 206Pb/238U ages (333-320 Ma, weighted mean age = 326.0 ± 2.8 Ma) for rim domains. Pre-metamorphic cores were identified only in one sample (206Pb/238U ages at 375.0 ± 3.9, 420.3 ± 4.4 and 426.2 ± 4.4 Ma). Most zircon ages bracket the time span between granulite-facies metamorphism in the Bohemian Massif (~345 Ma) and the late-Variscan anatectic overprint (Bavarian phase, ~325 Ma). It is argued that pre-existing zircon was variously affected by these metamorphic events and that primary magmatic growth zones were replaced by secondary textures as a result of diffusion reaction processes and replacement of zircon by dissolution and recrystallization followed by new zircon rim growth. Collectively, the results show that the zircons equilibrated during high-grade metamorphism and record

  9. The formation of high-grade ignimbrites, I: Experiments on high- and low-concentration transport systems containing sticky particles

    NASA Astrophysics Data System (ADS)

    Freundt, Armin

    High-grade ignimbrites are thought to be deposited by pyroclastic flows at temperatures exceeding minimum welding temperature or even solidus temperature. Corresponding pyroclastic-flow particles range from plastic to partially liquid and are able to aggregate or coalesce. This contrasts with particles in pyroclastic flows producing unwelded ignimbrite, which are capable of elastic grain interactions. The low aspect ratio and great areal extent of high-grade ignimbrites requires transport in a particulate state either by (a) high-concentration mass flow facilitated by fluidizing gas reducing internal friction, or by (b) expanded turbulent flow of low but downward increasing concentration. This paper presents experiments designed to investigate the effects of plastic to liquid particles on these two contrasting transport mechanisms. Gas fluidization experiments using polyethyleneglycole (PEG) powders heated above minimum sintering (Tms) and melting (Tm) temperatures cover a wide range of fluidization velocities (Umf>Ua>0.6.Ut) but are always in the bubbly fluidization regime similar to fluidized ignimbrite ash, where particle volume concentration outside the bubbles is high ( 10-1). When the powders reach a critical temperature Tm>=T>=Tms, defluidization by catastrophic particle aggregation immediately commences in both stationary and laterally moving fluidized beds as well as in experiments using mixtures of high- and low-Tm (>=30wt.%) PEG powders, when T>=Tms of the lower-Tm powder. This indicates that extended particulate transport at T>=Tms is not possible at such high particle concentrations. In the turbulent flow experiments, liquid sprays of molten PEG or water, vertically injected into a high-Re (>104) horizontal air flow, form a low-concentration (10-5 to 10-4) turbulent suspension current. Proximal formation of partially coalesced aggregates, which settle faster than individual particles, causes the measured downstream decay of sedimentation rate to be

  10. Transsacral transdiscal L5-S1 screws for the management of high-grade spondylolisthesis in an adolescent.

    PubMed

    Palejwala, Ali; Fridley, Jared; Jea, Andrew

    2016-06-01

    The surgical management of high-grade spondylolisthesis in adolescents remains a controversial issue. Because the basic procedure, posterolateral fusion, is associated with a significant rate of pseudarthrosis and listhesis progression, there is a pressing need for alternative surgical techniques. In the present report, the authors describe the case of an adolescent patient with significant low-back pain who was found to have Grade IV spondylolisthesis at L5-S1 that was treated with transsacral transdiscal screw fixation. Bilateral pedicle screws were placed starting from the top of the S-1 pedicle, across the L5-S1 intervertebral disc space, and into the L-5 body. At 14 months after surgery, the patient had considerable improvement in his pain and radiographic fusion across L5-S1. The authors conclude that transsacral transdiscal pedicle screws may serve as an efficacious and safe option for the correction of high-grade spondylolisthesis in adolescent patients. PMID:26894520

  11. Formation of high-grade ignimbrites Part II. A pyroclastic suspension current model with implications also for low-grade ignimbrites

    NASA Astrophysics Data System (ADS)

    Freundt, Armin

    Analogue experiments in part I led to the conclusion that pyroclastic flows depositing very high-grade ignimbrite move as dilute suspension currents. In the thermo-fluid-dynamical model developed, the degree of cooling of expanded turbulent pyroclastic flows dynamically evolves in response to entrainment of air and mass loss to sedimentation. Initial conditions of the currents are derived from column-collapse modeling for magmas with an initial H2O content of 1-3wt.% erupting through circular vents and caldera ring-fissures. The flows spread either longitudinally or radially from source up to a runout distance that increases with higher mass flux but decreases with higher gas content, temperature, bottom slope and coarser initial grain size. Progressive dilution by entrainment and sedimentation causes pyroclastic currents to transform into buoyant ash plumes at the runout distance. The ash plumes reach stratospheric heights and distribute 30-80% of the erupted material as widespread co-ignimbrite ash. Pyroclastic suspension currents with initial mass fluxes of 107-1012kg/s can spread for tens of kilometers with only limited cooling, although they move as supercritical, strongly entraining currents for the eruption conditions considered here. With increasing eruption mass flux, cooling during passage through the fountain diminishes while cooling during flow transport increases. The net effect is that eruption temperature exerts the prime control on emplacement temperature. Pyroclastic suspension currents can form welded ignimbrite across their entire extent if eruption temperature is To>1.3.Tmw, the minimum welding temperature. High eruption rates, a large fraction of fine ash, and a ring-fissure vent favor the formation of extensive high-grade ignimbrite. For very hot eruptions producing sticky, partially molten pyroclasts, analysis of particle aggregation systematics shows that factors favoring longer runout also favor more efficient aggregation, which reduces

  12. Highly mobile ferroelastic domain walls in compositionally graded ferroelectric thin films

    NASA Astrophysics Data System (ADS)

    Agar, J. C.; Damodaran, A. R.; Okatan, M. B.; Kacher, J.; Gammer, C.; Vasudevan, R. K.; Pandya, S.; Dedon, L. R.; Mangalam, R. V. K.; Velarde, G. A.; Jesse, S.; Balke, N.; Minor, A. M.; Kalinin, S. V.; Martin, L. W.

    2016-05-01

    Domains and domain walls are critical in determining the response of ferroelectrics, and the ability to controllably create, annihilate, or move domains is essential to enable a range of next-generation devices. Whereas electric-field control has been demonstrated for ferroelectric 180° domain walls, similar control of ferroelastic domains has not been achieved. Here, using controlled composition and strain gradients, we demonstrate deterministic control of ferroelastic domains that are rendered highly mobile in a controlled and reversible manner. Through a combination of thin-film growth, transmission-electron-microscopy-based nanobeam diffraction and nanoscale band-excitation switching spectroscopy, we show that strain gradients in compositionally graded PbZr1-xTixO3 heterostructures stabilize needle-like ferroelastic domains that terminate inside the film. These needle-like domains are highly labile in the out-of-plane direction under applied electric fields, producing a locally enhanced piezoresponse. This work demonstrates the efficacy of novel modes of epitaxy in providing new modalities of domain engineering and potential for as-yet-unrealized nanoscale functional devices.

  13. High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer

    PubMed Central

    Tearada, Hiroshi; Nagata, Masao; Mugiya, Soichi; Ozono, Seiichiro

    2012-01-01

    A 72-year-old man with a history of prostate cancer presented 7 years postradiotherapy with a painless, egg-sized, rapidly growing nodule on the left groin at the radiation site. He underwent left high orchiectomy under a diagnosis of groin lymph node metastasis of prostate cancer. The tumour had penetrated deep into the internal inguinal ring and was resected as proximally as possible to the internal ring with a positive surgical margin. Macroscopically, the left testis was intact in the resected specimen. Immunohistochemical staining revealed that the tumour consisted of myxofibrosarcoma (MFS) with spindle cells; and was positive for vimentin, cytokeratin (AE1/AE3), MIB-1 and CD68, and negative for α-SMA, S-100, CD34 and myogenin. Thus, the tumour was diagnosed as high-grade MFS of the spermatic cord. Postoperative CT revealed a right renal tumour and adrenal tumour. Right radial nephrectomy was performed and the patient was doing well at 10-month follow-up. PMID:23195821

  14. Efficient molecular subtype classification of high-grade serous ovarian cancer.

    PubMed

    Leong, Huei San; Galletta, Laura; Etemadmoghadam, Dariush; George, Joshy; Köbel, Martin; Ramus, Susan J; Bowtell, David

    2015-07-01

    High-grade serous carcinomas (HGSCs) account for approximately 70% of all epithelial ovarian cancers diagnosed. Using microarray gene expression profiling, we previously identified four molecular subtypes of HGSC: C1 (mesenchymal), C2 (immunoreactive), C4 (differentiated), and C5 (proliferative), which correlate with patient survival and have distinct biological features. Here, we describe molecular classification of HGSC based on a limited number of genes to allow cost-effective and high-throughput subtype analysis. We determined a minimal signature for accurate classification, including 39 differentially expressed and nine control genes from microarray experiments. Taqman-based (low-density arrays and Fluidigm), fluorescent oligonucleotides (Nanostring), and targeted RNA sequencing (Illumina) assays were then compared for their ability to correctly classify fresh and formalin-fixed, paraffin-embedded samples. All platforms achieved > 90% classification accuracy with RNA from fresh frozen samples. The Illumina and Nanostring assays were superior with fixed material. We found that the C1, C2, and C4 molecular subtypes were largely consistent across multiple surgical deposits from individual chemo-naive patients. In contrast, we observed substantial subtype heterogeneity in patients whose primary ovarian sample was classified as C5. The development of an efficient molecular classifier of HGSC should enable further biological characterization of molecular subtypes and the development of targeted clinical trials. PMID:25810134

  15. Highly mobile ferroelastic domain walls in compositionally graded ferroelectric thin films.

    PubMed

    Agar, J C; Damodaran, A R; Okatan, M B; Kacher, J; Gammer, C; Vasudevan, R K; Pandya, S; Dedon, L R; Mangalam, R V K; Velarde, G A; Jesse, S; Balke, N; Minor, A M; Kalinin, S V; Martin, L W

    2016-05-01

    Domains and domain walls are critical in determining the response of ferroelectrics, and the ability to controllably create, annihilate, or move domains is essential to enable a range of next-generation devices. Whereas electric-field control has been demonstrated for ferroelectric 180° domain walls, similar control of ferroelastic domains has not been achieved. Here, using controlled composition and strain gradients, we demonstrate deterministic control of ferroelastic domains that are rendered highly mobile in a controlled and reversible manner. Through a combination of thin-film growth, transmission-electron-microscopy-based nanobeam diffraction and nanoscale band-excitation switching spectroscopy, we show that strain gradients in compositionally graded PbZr1-xTixO3 heterostructures stabilize needle-like ferroelastic domains that terminate inside the film. These needle-like domains are highly labile in the out-of-plane direction under applied electric fields, producing a locally enhanced piezoresponse. This work demonstrates the efficacy of novel modes of epitaxy in providing new modalities of domain engineering and potential for as-yet-unrealized nanoscale functional devices. PMID:26878312

  16. High-grade astroblastoma in a child: Report of one case and review of literature

    PubMed Central

    de la Garma, Victor Hugo Escobar; Arcipreste, Arturo Ayala; Vázquez, Felipe Padilla; Aguilar, Ricardo Ramírez; Castruita, Uriel Oliva; Guerra, Rafael Mendizábal

    2014-01-01

    Background: Astroblastoma is a rare glial neoplastic lesion that affects children and adolescents; its histogenesis remains uncertain. It is considered to account for 0.5% of all glial neoplasms, and two different subtypes have been defined based upon histologic characteristics. Case Description: We present the case of a 9-year-old girl who presented with headache, motor symptoms, and seizures few days before she was admitted to our institution. Computed tomography (CT) and magnetic resonance imaging (MRI) scans showed an intra-axial heterogeneous frontoparietal lesion with a striking “bubbly” appearance in MRI T2-weighted sequences and features of intracranial hypertension. Gross total resection of the tumor was achieved and the histopathologic diagnosis revealed high-grade astroblastoma. We reviewed the current published cases of astroblastoma to highlight the demographic, clinical, radiologic, and pathologic data. Conclusion: Astroblastomas are a distinct clinicopathologic entity, with well-described radiologic, pathologic, and cytogenetic features. Its recurrence is high and efforts must be made to elucidate the role and usefulness of radiotherapy and chemotherapy in these tumors. PMID:25101206

  17. Highly mobile ferroelastic domain walls in compositionally graded ferroelectric thin films

    DOE PAGESBeta

    Damodaran, Anoop; Okatan, M. B.; Kacher, J.; Gammer, C.; Vasudevan, Rama; Pandya, S.; Dedon, L. R.; Mangalam, R. V.; Jesse, Stephen; Balke, Nina; et al

    2016-02-15

    Domains and domain walls are critical in determining the response of ferroelectrics, and the ability to controllably create, annihilate, or move domains is essential to enable a range of next-generation devices. Whereas electric-field control has been demonstrated for ferroelectric 180° domain walls, similar control of ferroelastic domains has not been achieved. Here, using controlled composition and strain gradients, we demonstrate deterministic control of ferroelastic domains that are rendered highly mobile in a controlled and reversible manner. Through a combination of thin-film growth, transmission-electron-microscopy-based nanobeam diffraction and nanoscale band-excitation switching spectroscopy, we show that strain gradients in compositionally graded PbZr1-xTixO3 heterostructuresmore » stabilize needle-like ferroelastic domains that terminate inside the film. These needle-like domains are highly labile in the out-of-plane direction under applied electric fields, producing a locally enhanced piezoresponse. This work demonstrates the efficacy of novel modes of epitaxy in providing new modalities of domain engineering and potential for as-yet-unrealized nanoscale functional devices.« less

  18. Aberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma

    PubMed Central

    Kannan, Kalpana; Kordestani, Gona Karimi; Galagoda, Anika; Coarfa, Cristian; Yen, Laising

    2015-01-01

    High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. By analyzing the mRNA-seq reads from The Cancer Genome Atlas (TCGA), we uncovered a novel cancer-enriched chimeric RNA as the result of splicing between MUC1, a highly glycosylated transmembrane mucin, TRIM46, a tripartite motif containing protein, and KRTCAP2, a keratinocyte associated protein. Experimental analyses by RT-PCR (reverse transcription PCR) and Sanger sequencing using an in-house cohort of 59 HGSC patient tumors revealed a total of six MUC1-TRIM46-KRTCAP2 isoforms joined by different annotated splice sites between these genes. These chimeric isoforms are not detected in non-cancerous ovaries, yet are present in three out of every four HGSC patient tumors, a significant frequency given the exceedingly heterogeneous nature of this disease. Transfection of the cDNA of MUC1-TRIM46-KRTCAP2 isoforms in mammalian cells led to the translation of mutant MUC1 fusion proteins that are unglycosylated and cytoplasmically localized as opposed to the cell membrane, a feature resembling the tumor-associated MUC1. Because the parental MUC1 is overexpressed in 90% of HGSC tumors and has been proposed as a clinical biomarker and therapeutic target, the chimeric MUC1-TRIM46-KRTCAP2 isoforms identified in this report could represent significantly better MUC1 variants for the same clinical utilities. PMID:26492273

  19. Insights Gained from Modeling High-Grade Glioma in the Mouse

    PubMed Central

    Rankin, Sherri L.; Zhu, Guo; Baker, Suzanne J.

    2011-01-01

    High grade gliomas (HGG) are devastating primary brain tumors with universally poor prognoses. Advances toward effective treatments require improved understanding of pathogenesis and relevant model systems for preclinical testing. Mouse models for HGG provide physiologically relevant experimental systems for analysis of HGG pathogenesis. There are advantages and disadvantages to the different methodologies used to generate such models, including implantation, genetic engineering or somatic gene transfer approaches. This review highlights how mouse models have provided insights into the contribution of specific mutations to tumor initiation, progression, and phenotype, the influence of tumor microenviroment, and the analysis of cell types that can give rise to glioma. HGGs are a highly heterogeneous group of tumors, and the complexity of diverse mutations within common signaling pathways as well as the developmental and cell-type context of transformation contribute to the overall diversity of glioma phenotype. Enhanced understanding of the mutations and cell types giving rise to HGG, along with the ability to design increasingly complex mouse models that more closely approximate the process of human gliomagenesis will continue to provide improved experimental systems for dissecting mechanisms of disease pathogenesis and for preclinical testing. PMID:22035336

  20. Formation conditions of high-grade beryllium ore at the Snezhnoe deposit, Eastern Sayan

    NASA Astrophysics Data System (ADS)

    Damdinova, L. B.; Smirnov, S. Z.; Damdinov, B. B.

    2015-11-01

    The structure and formation conditions of beryllium ore, as well as the fluorite and fluorite-microcline bodies at the Snezhnoe deposit in Eastern Sayan have been revealed and studied using geological, mineralogical, petrographic, and thermobarogeochemical methods. It has been established that the stringer and breccia ores were largely formed as a result of filling of open cavities (voids and fissures) rather than of replacement of low-Ca host rocks. Three types of high-grade ore consist of almost the same set of minerals in different proportions. Calcium and fluorine necessary for fluorite formation in three main types of ore have been supplied with the near-neutral high-F solutions (type I) and the solutions of elevated alkalinity (II, III types) in the form of complex compounds like Na2CaF 4 0 , Ca2Cl3F0, etc. Beryllium minerals were deposited within a temperature interval from ≥340 to 230°C due to the cooling of the solution and binding of F into fluorite with the breakdown of Be fluorine complexes and intense deposition of Be minerals.

  1. Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas.

    PubMed

    Shi, Wenyin; Palmer, Joshua D; Werner-Wasik, Maria; Andrews, David W; Evans, James J; Glass, Jon; Kim, Lyndon; Bar-Ad, Voichita; Judy, Kevin; Farrell, Christopher; Simone, Nicole; Liu, Haisong; Dicker, Adam P; Lawrence, Yaacov R

    2016-05-01

    Panobinostat is an oral HDAC inhibitor with radiosensitizing activity. We investigated the safety, tolerability and preliminary efficacy of panobinostat combined with fractionated stereotactic re-irradiation therapy (FSRT) for recurrent high grade gliomas. Patients with recurrent high grade gliomas were enrolled in a 3 + 3 dose escalation study to determine dose limiting toxicities (DLTs), maximum tolerated dose (MTD), safety, tolerability, and preliminary efficacy. FSRT was prescribed to 30-35 Gy delivered in 10 fractions. Panobinostat was administrated concurrently with radiotherapy. Of 12 evaluable patients, 8 had recurrent GBM, and 4 had recurrent anaplastic astrocytoma. There were three grade 3 or higher toxicities in each the 10 and 30 mg cohorts. In the 30 mg cohort, there was one DLT; grade 4 neutropenia. One patient developed late grade 3 radionecrosis. The median follow up was 18.8 months. The PFS6 was 67, 33, and 83 % for 10, 20, and 30 mg cohorts, respectively. The median OS was 7.8, 6.1 and 16.1 months for the 10, 20 and 30 mg cohorts, respectively. Panobinostat administrated with FSRT is well tolerated at 30 mg. A phase II trial is warranted to assess the efficacy of panobinostat plus FSRT for recurrent glioma. PMID:26821711

  2. A novel, integrated PET-guided MRS technique resulting in more accurate initial diagnosis of high-grade glioma.

    PubMed

    Kim, Ellen S; Satter, Martin; Reed, Marilyn; Fadell, Ronald; Kardan, Arash

    2016-06-01

    Glioblastoma multiforme (GBM) is the most common and lethal malignant glioma in adults. Currently, the modality of choice for diagnosing brain tumor is high-resolution magnetic resonance imaging (MRI) with contrast, which provides anatomic detail and localization. Studies have demonstrated, however, that MRI may have limited utility in delineating the full tumor extent precisely. Studies suggest that MR spectroscopy (MRS) can also be used to distinguish high-grade from low-grade gliomas. However, due to operator dependent variables and the heterogeneous nature of gliomas, the potential for error in diagnostic accuracy with MRS is a concern. Positron emission tomography (PET) imaging with (11)C-methionine (MET) and (18)F-fluorodeoxyglucose (FDG) has been shown to add additional information with respect to tumor grade, extent, and prognosis based on the premise of biochemical changes preceding anatomic changes. Combined PET/MRS is a technique that integrates information from PET in guiding the location for the most accurate metabolic characterization of a lesion via MRS. We describe a case of glioblastoma multiforme in which MRS was initially non-diagnostic for malignancy, but when MRS was repeated with PET guidance, demonstrated elevated choline/N-acetylaspartate (Cho/NAA) ratio in the right parietal mass consistent with a high-grade malignancy. Stereotactic biopsy, followed by PET image-guided resection, confirmed the diagnosis of grade IV GBM. To our knowledge, this is the first reported case of an integrated PET/MRS technique for the voxel placement of MRS. Our findings suggest that integrated PET/MRS may potentially improve diagnostic accuracy in high-grade gliomas. PMID:27122050

  3. PREFACE: Proceedings of the 11th European Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis

    NASA Astrophysics Data System (ADS)

    2010-07-01

    This volume of IOP Conference Series: Materials Science and Engineering contains papers from the 11th Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis which took place from 10-14 May 2009 in the Hotel Faltom, Gdynia, Poland. The primary aim of this series of workshops is to assess the state-of-the-art and reliability of microbeam analysis techniques. The workshops also provide a forum where students and young scientists starting out on careers in microbeam analysis can meet and discuss with the established experts. The workshops have a very distinct format comprising invited plenary lectures by internationally recognized experts, poster presentations by the participants and round table discussions on the key topics led by specialists in the field. For this workshop EMAS invited speakers on the following topics: EPMA, EBSD, fast energy-dispersive X-ray spectroscopy, three-dimensional microanalysis, and micro-and nanoanalysis in the natural resources industry. The continuing relevance of the EMAS workshops and the high regard in which they are held internationally can be seen from the fact that 69 posters from 16 countries were on display at the meeting and that the participants came from as far away as Japan and the USA. A number of participants with posters were invited to give short oral presentations of their work in two dedicated sessions. As at previous workshops there was also a special oral session for young scientists. Small cash prizes were awarded for the three best posters and for the best oral presentation by a young scientist. The prize for the best poster went to the contribution by G Tylko, S Dubchak, Z Banach and K Turnau, entitled Monte Carlo simulation for an assessment of standard validity and quantitative X-ray microanalysis in plant. Joanna Wojewoda-Budka of the Institute of Metallurgy and Materials Science, Krakow, received the prize for the best oral presentation by a

  4. PREFACE: Proceedings of the 11th European Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis

    NASA Astrophysics Data System (ADS)

    2010-07-01

    This volume of IOP Conference Series: Materials Science and Engineering contains papers from the 11th Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis which took place from 10-14 May 2009 in the Hotel Faltom, Gdynia, Poland. The primary aim of this series of workshops is to assess the state-of-the-art and reliability of microbeam analysis techniques. The workshops also provide a forum where students and young scientists starting out on careers in microbeam analysis can meet and discuss with the established experts. The workshops have a very distinct format comprising invited plenary lectures by internationally recognized experts, poster presentations by the participants and round table discussions on the key topics led by specialists in the field. For this workshop EMAS invited speakers on the following topics: EPMA, EBSD, fast energy-dispersive X-ray spectroscopy, three-dimensional microanalysis, and micro-and nanoanalysis in the natural resources industry. The continuing relevance of the EMAS workshops and the high regard in which they are held internationally can be seen from the fact that 69 posters from 16 countries were on display at the meeting and that the participants came from as far away as Japan and the USA. A number of participants with posters were invited to give short oral presentations of their work in two dedicated sessions. As at previous workshops there was also a special oral session for young scientists. Small cash prizes were awarded for the three best posters and for the best oral presentation by a young scientist. The prize for the best poster went to the contribution by G Tylko, S Dubchak, Z Banach and K Turnau, entitled Monte Carlo simulation for an assessment of standard validity and quantitative X-ray microanalysis in plant. Joanna Wojewoda-Budka of the Institute of Metallurgy and Materials Science, Krakow, received the prize for the best oral presentation by a

  5. Diffusion-weighted imaging-based probabilistic segmentation of high- and low-proliferative areas in high-grade gliomas

    PubMed Central

    Fritzsche, Klaus H.; Thieke, Christian; Klein, Jan; Parzer, Peter; Weber, Marc-André; Stieltjes, Bram

    2012-01-01

    Abstract The apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) correlates inversely with tumor proliferation rates. High-grade gliomas are typically heterogeneous and the delineation of areas of high and low proliferation is impeded by partial volume effects and blurred borders. Commonly used manual delineation is further impeded by potential overlap with cerebrospinal fluid and necrosis. Here we present an algorithm to reproducibly delineate and probabilistically quantify the ADC in areas of high and low proliferation in heterogeneous gliomas, resulting in a reproducible quantification in regions of tissue inhomogeneity. We used an expectation maximization (EM) clustering algorithm, applied on a Gaussian mixture model, consisting of pure superpositions of Gaussian distributions. Soundness and reproducibility of this approach were evaluated in 10 patients with glioma. High- and low-proliferating areas found using the clustering correspond well with conservative regions of interest drawn using all available imaging data. Systematic placement of model initialization seeds shows good reproducibility of the method. Moreover, we illustrate an automatic initialization approach that completely removes user-induced variability. In conclusion, we present a rapid, reproducible and automatic method to separate and quantify heterogeneous regions in gliomas. PMID:22487677

  6. Cognitive functioning in long-term survivors of high-grade glioma.

    PubMed

    Archibald, Y M; Lunn, D; Ruttan, L A; Macdonald, D R; Del Maestro, R F; Barr, H W; Pexman, J H; Fisher, B J; Gaspar, L E; Cairncross, J G

    1994-02-01

    In a pilot study, two groups of patients with malignant glioma underwent sequential neuropsychological evaluations after successful tumor treatment. Group 1 included nine patients treated from 1981 to 1985; all patients received irradiation and eight underwent chemotherapy. The baseline neuropsychological assessment was performed 1 to 63 months after tumor diagnosis, with follow-up evaluations at irregular intervals over the next 3 to 7 years. Six patients in Group 1 exhibited impairment on most measures at baseline; subsequently, two patients developed profound cognitive impairment. Initially, three patients functioned in the average range on most tasks; thereafter, two deteriorated on one measure each. Group 2 was ascertained prospectively and included 16 patients treated from 1985 to 1987, all of whom received irradiation and chemotherapy. The first evaluation was performed 18 months after diagnosis, then every 6 months for 2 years, and then yearly. Compared to a control group, those in Group 2 had significant cognitive impairment at baseline. Cognitive performance did not change over the next 12 months in 10 patients who remained free of tumor, but within 2 years of baseline testing, deterioration on specific tasks was evident in two of seven disease-free survivors. When last tested, five of six disease-free survivors had deteriorated on one or more measures. Unlike Group 1, severe global cognitive impairment was not seen, perhaps because Group 2 was followed for a shorter time. Verbal and nonverbal composite scores derived from intelligence quotient (IQ) tests showed less impairment at baseline than did other measures and were more likely to remain stable subsequently. Verbal memory and sustained attention were the most impaired at baseline, and verbal learning and flexibility in thinking showed the greatest tendency to decline over time. Cognitive functioning in survivors of high-grade glioma is best measured and monitored by tests that probe a broader

  7. Accuracy of detection of high-grade cervical intraepithelial neoplasia using electrical impedance spectroscopy with colposcopy

    PubMed Central

    Tidy, JA; Brown, BH; Healey, TJ; Daayana, S; Martin, M; Prendiville, W; Kitchener, HC

    2013-01-01

    Objective To determine if electrical impedance spectroscopy (EIS) improves the diagnostic accuracy of colposcopy when used as an adjunct. Design Prospective, comparative, multi-centre clinical study. Setting Three colposcopy clinics: two in England and one in Ireland. Population Women referred with abnormal cytology. Methods In phase 1, EIS was assessed against colposcopic impression and histopathology of the biopsies taken. In phase 2, a probability index and cut-off value for the detection of high-grade cervical intraepithelial neoplasia (HG–CIN, i.e. grade CIN2+) was derived to indicate sites for biopsy. EIS data collection and analyses were performed in real time and blinded to the clinician. The phase-2 data were analysed using different cut-off values to assess performance of EIS as an adjunct. Main outcome measure Histologically confirmed HG–CIN (CIN2+). Results A total of 474 women were recruited: 214 were eligible for analysis in phase 1, and 215 were eligible in phase 2. The average age was 33.2 years (median age 30.3 years, range 20–64 years) and 48.5% (208/429) had high-grade cytology. Using the cut-off from phase 1 the accuracy of colposcopic impression to detect HG–CIN when using EIS as an adjunct at the time of examination improved the positive predictive value (PPV) from 78.1% (95% CI 67.5–86.4) to 91.5%. Specificity was also increased from 83.5% (95% CI 75.2–89.9) to 95.4%, but sensitivity was significantly reduced from 73.6% (95% CI 63.0–82.5) to 62.1%, and the negative predictive value (NPV) was unchanged. The positive likelihood ratio for colposcopic impression alone was 4.46. This increased to 13.5 when EIS was used as an adjunct. The overall accuracy of colposcopy when used with EIS as an adjunct was assessed by varying the cut-off applied to a combined test index. Using a cut-off set to give the same sensitivity as colposcopy in phase 2, EIS increased the PPV to detect HG–CIN from 53.5% (95% CI 45.0–61.8) to 67%, and

  8. The Effect of a Zoo-Based Experiential Academic Science Program on High School Students' Math and Science Achievement and Perceptions of School Climate

    NASA Astrophysics Data System (ADS)

    Mulkerrin, Elizabeth A.

    The purpose of this study was to determine the effect of an 11th-grade and 12th-grade zoo-based academic high school experiential science program compared to a same school-district school-based academic high school experiential science program on students' pretest and posttest science, math, and reading achievement, and student perceptions of program relevance, rigor, and relationships. Science coursework delivery site served as the study's independent variable for the two naturally formed groups representing students (n = 18) who completed a zoo-based experiential academic high school science program and students (n = 18) who completed a school-based experiential academic high school science program. Students in the first group, a zoo-based experiential academic high school science program, completed real world, hands-on projects at the zoo while students in the second group, those students who completed a school-based experiential academic high school science program, completed real world, simulated projects in the classroom. These groups comprised the two research arms of the study. Both groups of students were selected from the same school district. The study's two dependent variables were achievement and school climate. Achievement was analyzed using norm-referenced 11th-grade pretest PLAN and 12th-grade posttest ACT test composite scores. Null hypotheses were rejected in the direction of improved test scores for both science program groups---students who completed the zoo-based experiential academic high school science program (p < .001) and students who completed the school-based experiential academic high school science program (p < .001). The posttest-posttest ACT test composite score comparison was not statistically different ( p = .93) indicating program equipoise for students enrolled in both science programs. No overall weighted grade point average score improvement was observed for students in either science group, however, null hypotheses were

  9. Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation.

    PubMed

    Johnson, D B; Thompson, J M; Corwin, J A; Mosley, K R; Smith, M T; de los Reyes, R A; Daly, M B; Petty, A M; Lamaster, D; Pierson, W P

    1987-05-01

    Employment of postoperative brain irradiation in the initial management of high-grade malignant glial tumors has now become standard. The addition of conventional chemotherapy to irradiation has not significantly improved median survival beyond 1 year. We treated 25 consecutive patients (13 pilot patients and 12 protocol patients) with histologically confirmed unresectable grade 3 or 4 malignant gliomas with high-dose BCNU (carmustine) followed by autologous bone marrow transplantation and whole brain irradiation. Within 3 weeks of initial surgery, each patient had autologous bone marrow stored (median 2 X 10(8) nucleated cells/kg), and then received BCNU 1,050 mg/m2 intravenously (IV). Peripheral granulocytes recovered (greater than 500/microL) at a median of 19 days (range, 10 to 37 days), and platelets recovered (greater than 20,000/microL) at a median of 18 days (range, 13 to 40 days), following bone marrow infusion. Patients received 60 Gy whole brain irradiation when granulocytes were greater than 1,500/microL. Toxicity was well tolerated. Nausea occurred in 19 patients (76%); however, only eight patients (32%) experienced vomiting (mild in three, moderate in five). Eleven patients (44%) did not require empiric antibiotics, six of whom never developed an absolute granulocyte count less than 500/microL. Three patients with a poor performance status died early (one seizure with vomiting and asphyxiation; one, klebsiella urinary tract infection (UTI) with bacteremia; one, candidal pneumonia), and one additional patient who was performing well died of pulmonary hemorrhage. The 13 pilot patients have now been followed for a median of 23 months, with a significant survival advantage compared with the 52 consecutive historical control patients who received similar surgery and radiotherapy without high-dose BCNU (P = .037). The overall study group of 25 patients also has a significant survival advantage when compared with the same historical control group, with a

  10. Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

    PubMed Central

    Pollock, K G J; Kavanagh, K; Potts, A; Love, J; Cuschieri, K; Cubie, H; Robertson, C; Cruickshank, M; Palmer, T J; Nicoll, S; Donaghy, M

    2014-01-01

    Background: In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established. Methods: We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20–21 in 2008–2012. Results: By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women. Conclusions: To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake. PMID:25180766

  11. The Effects of Part-Time Employment on High School Students' Grade Point Averages and Rate of School Attendance.

    ERIC Educational Resources Information Center

    Heffez, Jack

    To determine what effects employment will have on high school students' grade point averages and rate of school attendance, the author involved fifty-six students in an experiment. Twenty-eight students were employed part-time under the Youth Incentive Entitlement Project (YIEP). The twenty-eight students in the control group were eligible for…

  12. The Impact of Interactive Whiteboard Technology on Ninth Grade English at Selected Rural High Schools in Upstate South Carolina

    ERIC Educational Resources Information Center

    Smith, Mark S.

    2013-01-01

    The purpose of this study was to determine the impact of interactive whiteboard technology on ninth grade English End of Course scores in two high schools in the Upstate of South Carolina in the school year 2011-2012. This study also sought to determine what impact interactive whiteboard technology had on the factors of gender, socio-economic…

  13. Degree of Student's Assimilation to the Meaning of the Term Citizenships in the Schools High Grade Basic Level in Jordan

    ERIC Educational Resources Information Center

    Al-Zboon, Mohamed Saleem

    2014-01-01

    This study aimed at identifying the degree of the Assimilation of the meaning of the term "CITIZENSHIP" by the high grade basic level school students in Jordan. The research sample was composed of (1,116) male and female students during the scholastic year 2012/2013. To collect data and then measure results, the standard measurement tool…

  14. The Relationship between Ninth-Grade Retention and On-Time Graduation in a Southeast Texas High School

    ERIC Educational Resources Information Center

    Bornsheuer, Jennifer N.; Polonyi, Monica A.; Andrews, Malitta; Fore, Brenda; Onwuegbuzie, Anthony J.

    2011-01-01

    Currently, there are approximately 1.3 million annual high school dropouts who potentially might lose $355 billion of income over their lifetimes. Effectively addressing retention and dropout issues has far-reaching societal implications. Therefore, this study examined the relationship between ninth-grade retention and on-time graduation. For the…

  15. Effects of Partner's Ability on the Achievement and Conceptual Organization of High-Achieving Fifth-Grade Students.

    ERIC Educational Resources Information Center

    Carter, Glenda; Jones, M. Gail; Rua, Melissa

    2003-01-01

    Investigates high-achieving fifth-grade students' achievement gains and conceptual reorganization on convection. Features an instructional sequence of three dyadic inquiry investigations related to convection currents as well as pre- and post-assessment consisting of a multiple-choice test, a card sorting task, construction of a concept map, and…

  16. A Comparative Study of Teachers' Attitudes and Practices regarding Homework in the Elementary, Middle, and High School Grades

    ERIC Educational Resources Information Center

    Peltier, Courtney Pisarich

    2011-01-01

    The purpose of this study was to examine the attitudes and practices of elementary, middle, and high school teachers regarding homework. In addition, the study sought to find if there was a relationship between the teachers' attitudes and practices of homework, as well as finding the differences between the grade levels. The questionnaire used…

  17. No Evidence for Association of SCO2 Heterozygosity with High-Grade Myopia or Other Diseases with Possible Mitochondrial Dysfunction.

    PubMed

    Piekutowska-Abramczuk, Dorota; Kocyła-Karczmarewicz, Beata; Małkowska, Maja; Łuczak, Sylwia; Iwanicka-Pronicka, Katarzyna; Siegmund, Stephanie; Yang, Hua; Wen, Quan; Hoang, Quan V; Silverman, Ronald H; Kowalski, Paweł; Szczypińska, Olga; Czornak, Kamila; Zimowski, Janusz; Płoski, Rafał; Pilch, Jacek; Ciara, Elżbieta; Zaremba, Jacek; Krajewska-Walasek, Małgorzata; Schon, Eric A; Pronicka, Ewa

    2016-01-01

    SCO2 mutations cause recessively inherited cytochrome c oxidase deficiency. Recently Tran-Viet et al. proposed that heterozygosity for pathogenic SCO2 variants, including the common E140K variant, causes high-grade myopia. To investigate the association of SCO2 mutations with myopia, ophthalmic examinations were performed on 35 E140K carriers, one homozygous infant, and on a mouse model of Sco2 deficiency. Additionally, a screen for other putative effects of SCO2 heterozygosity was carried out by comparing the prevalence of the common E140K variant in a population of patients with undiagnosed diseases compatible with SCO2-related pathogenesis to that in a general population sample. High-grade myopia was not identified in any of the studied individuals. Of the carriers, 17 were emmetropic, and 18 possessed refractive errors. Additionally, no significant axial elongation indicative of high-grade myopia was found in mice carrying E129K (corresponding to E140K in humans) knock-in mutations. The prevalence of E140K carriers in the symptomatic cohort was evaluated as 1:103 (CI: 0.44-2.09) and did not differ significantly from the population prevalence (1:147, CI: 0.45-1.04).Our study demonstrates that heterozygosity for pathogenic SCO2 variants is not associated with high-grade myopia in either human patients or in mice. PMID:26427993

  18. Helping Students Make the Transition into High School: The Effect of Ninth Grade Academies on Students' Academic and Behavioral Outcomes

    ERIC Educational Resources Information Center

    Somers, Marie-Andrée; Garcia, Ivonne

    2016-01-01

    Ninth Grade Academies (NGAs)--also called Freshman Academies--have attracted national attention as a particularly intensive and promising approach for supporting a successful transition for high school freshmen. An NGA is a self-contained learning community for ninth-graders that operates as a school within a school. NGAs have four core structural…

  19. Weighting for Recognition: Accounting for Advanced Placement and Honors Courses when Calculating High School Grade Point Average

    ERIC Educational Resources Information Center

    Sadler, Philip M.; Tai, Robert H.

    2007-01-01

    Honors and advanced placement (AP) courses are commonly viewed as more demanding than standard high school offerings. Schools employ a range of methods to account for such differences when calculating grade point average and the associated rank in class for graduating students. In turn, these statistics have a sizeable impact on college admission…

  20. Online Reading Comprehension among Seventh Grade Students with High Incidence Disabilities in Inclusive Settings: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Robbins, Katherine R.

    2010-01-01

    Because research exploring how students with disabilities read and comprehend on the Internet is scarce, a mixed methods study was implemented to determine if Internet Reciprocal Teaching (IRT) is an effective intervention for improving online reading comprehension among seventh grade students with high-incidence disabilities in inclusive…

  1. Reflections on Teaching and Learning the Arts: A Middle-Grade Classroom and a High School for the Arts

    ERIC Educational Resources Information Center

    Barilla, Rosemary; Brown, Tina Boyer

    2015-01-01

    Rosemary Barilla, a middle-grade language arts teacher, inspired by her own dedication to the arts, describes the ways she integrates the fine arts into her classroom program that is designed to teach reading and writing. Tina Boyer Brown, a founding teacher at The Chicago High School for the Arts (ChiArts®), describes the school as a place where…

  2. Contextual Factors Associated with the Validity of SAT Scores and High School GPA for Predicting First-Year College Grades

    ERIC Educational Resources Information Center

    Kobrin, Jennifer L.; Patterson, Brian F.

    2011-01-01

    Prior research has shown that there is substantial variability in the degree to which the SAT and high school grade point average (HSGPA) predict 1st-year college performance at different institutions. This article demonstrates the usefulness of multilevel modeling as a tool to uncover institutional characteristics that are associated with this…

  3. High histologic grade and increased relative content of tryptophan in breast cancer using ratios from fingerprint fluorescence spectral peaks

    NASA Astrophysics Data System (ADS)

    Sordillo, Laura A.; Sordillo, Peter P.; Budansky, Yury; Pu, Yang; Alfano, R. R.

    2015-03-01

    Histologic grade is a very important, but underappreciated, parameter of breast cancer aggressiveness. Despite its importance, it has historically not been included as one of the criteria for staging of this cancer. In this study, spectral fluorescence profiles from patients with breast carcinoma were acquired. Ratios of emission peaks at 340 over 440,460 nm from biomolecules in malignant and normal samples were calculated. Cancerous over normal ratios (double ratio (DR) method) were evaluated with respect to tumor characteristics. Increased tryptophan content in breast cancer tissues correlates strongly with high grade, but not with lymph node metastases, estrogen receptor, progesterone receptor or Her-2-Neu receptor status.

  4. A comparison of geochemical core scanning methods on high-grade metamorphic COSC-1 cores

    NASA Astrophysics Data System (ADS)

    Harms, Ulrich; Hierold, Johannes; Meima, Jeannette; Rammlmair, Dieter; Kollaske, Tina

    2016-04-01

    Micro-XRF core scanning of marine and lacustrine sediment cores provides geochemical data for many elements and has become a standard tool in paleoclimate and environmental studies. In contrast, such investigations are unusual on crystalline cores due to limitations such as crystal lattice reflections. We tested micro-XRF scanning on gneisses and mylonites of the COSC-1 ICDP project in the Swedish Caledonides. The data obtained was compared with new high-resolution half-split core surface mapping using an ED-XRF instrument (50 μm res.) and Laser Induced Breakdown Spectroscopy (LIBS) core scanner (200 μm res.). In addition, an assessment was made with whole-core box oversight XRF scanning (Minalyze AB) with 10 cm resolution. High-grade metamorphic rocks including metasedimentary leucocratic gneisses and intercalated mica-rich mylonites of the lower Seve Nappe drilled during COSC-1 have been investigated to compare scanning methods. All data sets show a clear compositional step between gneiss and mylonite indicating a metasedimentary mixed layer origin (sandy to clayey) of the source rocks with extremely limited metasomatic exchange. Micro-XRF profiles are in full accord with high-resolution mapping data but cannot reproduce the detailed structural information provided by mapping data. LIBS data include light elements such as Li that are not measurable with XRF methods and confirm a sharp non-metasomatic transition between gneisses and mylonite. The whole-core box XRF scans are extremely useful to scan the 2500 m of cored material in a short time compared with other methods, and the data is very helpful, for example, for geochemical reconstructing of lithologies.

  5. Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern

    PubMed Central

    ÖZNUR, MELTEM; KOCA, SEVIM BAYKAL; YILDIZ, PELIN; BAHADIR, BURAK; BEHZATOĞLU, KEMAL

    2015-01-01

    High-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas. PMID:26622858

  6. High-efficiency cell structures and processes applied to photovoltaic-grade Czochralski silicon

    SciTech Connect

    Gee, J.M.; King, R.R.; Mitchell, K.W.

    1996-12-01

    The authors performed a detailed study to examine the limiting performance available using photovoltaic-grade Cz silicon. Photovoltaic-grade silicon refers to silicon produced by the photovoltaic industry, which may differ from the silicon used in the semiconductor device industry in impurity and defect concentrations.The study included optimization of fabrication processes, development of advanced device structures, and detailed model calculations to project future performance improvements. Process and device optimization resulted in demonstration of 75-{micro}s bulk lifetimes and 17.6%-efficient large-area cells using photovoltaic-grade Cz silicon. Detailed calculations based on the material and device evaluation of the present work project efficiencies of 20% for photovoltaic-grade Cz silicon with properly optimized processing and device structures.

  7. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

    PubMed Central

    Fontebasso, Adam M.; Papillon-Cavanagh, Simon; Schwartzentruber, Jeremy; Nikbakht, Hamid; Gerges, Noha; Fiset, Pierre-Olivier; Bechet, Denise; Faury, Damien; De Jay, Nicolas; Ramkissoon, Lori; Corcoran, Aoife; Jones, David T W; Sturm, Dominik; Johann, Pascal; Tomita, Tadanori; Goldman, Stewart; Nagib, Mahmoud; Bendel, Anne; Goumnerova, Liliana; Bowers, Daniel C.; Leonard, Jeffrey R.; Rubin, Joshua B.; Alden, Tord; Browd, Samuel; Geyer, J. Russell; Leary, Sarah; Jallo, George; Cohen, Kenneth; Gupta, Nalin; Prados, Michael D.; Carret, Anne-Sophie; Ellezam, Benjamin; Crevier, Louis; Klekner, Almos; Bognar, Laszlo; Hauser, Peter; Garami, Miklos; Myseros, John; Dong, Zhifeng; Siegel, Peter M.; Malkin, Hayley; Ligon, Azra; Albrecht, Steffen; Pfister, Stefan M.; Ligon, Keith L.; Majewski, Jacek; Jabado, Nada; Kieran, Mark W

    2014-01-01

    Midline pediatric high-grade astrocytomas (pHGAs) are incurable with few treatment targets identified. Most tumors harbor K27M mutations on histone 3 variants. In 40 treatment-naïve midline pHGAs, 39 analyzed by whole-exome sequencing, we find additional somatic mutations specific to tumor location. Gain-of-function mutations in ACVR1 occur in tumors of the pons in conjunction with H3.1 K27M, while FGFR1 mutations/fusions occur in thalamic tumors associated with H3.3 K27M. Hyper-activation of the bone morphogenetic protein (BMP)/ACVR1 developmental pathway in pHGAs harbouring ACVR1 mutations led to increased phospho-SMAD1/5/8 expression and up-regulation of BMP downstream early response genes in tumour cells. Global DNA methylation profiles were significantly associated with the K27M mutation regardless of the mutant H3 variant and irrespective of tumor location, supporting its role in driving the epigenetic phenotype. This significantly expands the potential treatment targets and further justifies pre-treatment biopsy in pHGA as a means to orient therapeutic efforts in this disease. PMID:24705250

  8. Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas

    PubMed Central

    Wang, Dongliang; Zhang, Qingjun; Xue, Yake; Jiao, Hongliang; Zhan, Lei; Ma, Qian; Wei, Xinting

    2015-01-01

    Background The transcription factor forkhead box D3 (FOXD3) plays important roles in the development of neural crest and has been shown to suppress the development of various cancers. However, the expression and its potential biological roles of FOXD3 in high-grade gliomas (HGGs) remain unknown. Methods The mRNA and protein expression levels of FOXD3 were examined using real-time quantitative PCR and western blotting in 23 HGG and 13 normal brain samples, respectively. Immunohistochemistry was used to validate the expression FOXD3 protein in 184 HGG cases. The association between FOXD3 expression and the prognosis of HGG patients were analyzed using Kaplan-Meier survival curves and Cox proportional hazards regression models. In addition, we further examined the effects of FOXD3 on the proliferation and serum starvation-induced apoptosis of glioma cells. Results In comparison to normal brain tissues, FOXD3 expression was significantly decreased in HGG tissues at both mRNA and protein levels. Immunohistochemistry further validated the expression of FOXD3 in HGG tissues. Moreover, low FOXD3 expression was significantly associated with poor prognosis in HGG patients. Depletion of FOXD3 expression promoted glioma cell proliferation and inhibited serum starvation-induced apoptosis, whereas overexpression of FOXD3 inhibited glioma cell proliferation and promoted serum starvation-induced apoptosis. Conclusions Our results indicated that FOXD3 might serve as an independent prognostic biomarker and a potential therapeutic target for HGGs, which warrant further investigation. PMID:26011451

  9. Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas

    PubMed Central

    Roelz, Roland; Reinacher, Peter; Jabbarli, Ramazan; Kraeutle, Rainer; Hippchen, Beate; Egger, Karl; Weyerbrock, Astrid; Machein, Marcia

    2015-01-01

    Leptomeningeal metastasis (LM) of high grade gliomas (HGG) can lead to devastating disease courses. Understanding of risk factors for LM is important to identify patients at risk. We reviewed patient records and magnetic resonance imaging (MRI) of all patients with a first diagnosis of HGG who underwent surgery in our institution between 2008 and 2012. To assess the influence of potential risk factors for LM and the impact of LM on survival multivariate statistics were performed. 239 patients with a diagnosis of HGG and at least 6 months of MRI and clinical follow-up were included. LM occurred in 27 (11%) patients and was symptomatic in 17 (65%). A strong correlation of surgical entry to the ventricle and LM was found (HR: 8.1). Ventricular entry was documented in 137 patients (57%) and LM ensued in 25 (18%) of these. Only two (2%) of 102 patients without ventricular entry developed LM. Median overall survival of patients after diagnosis of LM (239 days) was significantly shorter compared to patients without LM (626 days). LM is a frequent complication in the course of disease of HGG and is associated with poor survival. Surgical entry to the ventricle is a key risk factor for LM. PMID:26635136

  10. FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis.

    PubMed

    Levanon, K; Sapoznik, S; Bahar-Shany, K; Brand, H; Shapira-Frommer, R; Korach, J; Hirsch, M S; Roh, M H; Miron, A; Liu, J F; Vena, N; Ligon, A H; Fotheringham, S; Bailey, D; Flavin, R J; Birrer, M J; Drapkin, R I

    2014-08-28

    Serous ovarian carcinoma is the most lethal gynecological malignancy in Western countries. The molecular events that underlie the development of the disease have been elusive for many years. The recent identification of the fallopian tube secretory epithelial cells (FTSECs) as the cell-of-origin for most cases of this disease has led to studies aimed at elucidating new candidate therapeutic pathways through profiling of normal FTSECs and serous carcinomas. Here we describe the results of transcriptional profiles that identify the loss of the tumor suppressive transcription factor FOXO3a in a vast majority of high-grade serous ovarian carcinomas. We show that FOXO3a loss is a hallmark of the earliest stages of serous carcinogenesis and occurs both at the DNA, RNA and protein levels. We describe several mechanisms responsible for FOXO3a inactivity, including chromosomal deletion (chromosome 6q21), upregulation of miRNA-182 and destabilization by activated PI3K and MEK. The identification of pathways involved in the pathogenesis of ovarian cancer can advance the management of this disease from being dependant on surgery and cytotoxic chemotherapy alone to the era of targeted therapy. Our data strongly suggest FOXO3a as a possible target for clinical intervention. PMID:24077281

  11. YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.

    PubMed

    Hua, G; Lv, X; He, C; Remmenga, S W; Rodabough, K J; Dong, J; Yang, L; Lele, S M; Yang, P; Zhou, J; Karst, A; Drapkin, R I; Davis, J S; Wang, C

    2016-04-28

    Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression of HGSC derived from FTSECs remains unclear. In this study, we found that the Hippo/Yes-associated protein (YAP) signaling pathway has a critical role in the initiation and progression of fallopian tube and ovarian HGSC. Importantly, YAP was overexpressed in inflammatory and cancerous fallopian tube tissues. Further, overexpression of wild-type YAP, or constitutively active YAP in immortalized FTSECs, induced cell proliferation, migration, colony formation and tumorigenesis. Moreover, the Hippo/YAP and the fibroblast growth factor (FGF) signaling pathways formed an autocrine/paracrine-positive feedback loop to drive the progression of the FTSEC-derived HGSC. Evidence in this study strongly suggests that combined therapy with inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel therapeutic strategy to treat fallopian tube and ovarian HGSC. PMID:26364602

  12. mTORC1 Maintains the Tumorigenicity of SSEA-4+ High-Grade Osteosarcoma

    PubMed Central

    Zhang, Wu; Ding, Meng-Lei; Zhang, Jia-Nian; Qiu, Jian-Ru; Shen, Yu-Hui; Ding, Xiao-Yi; Deng, Lian-Fu; Zhang, Wei-Bin; Zhu, Jiang

    2015-01-01

    Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exit and terminal differentiation, which underpins osteosarcoma formation coupled with dedifferentiation. Recently, the level of p-S6K was shown to independently predict the prognosis for osteosarcomas, while the reason behind this is not understood. Here we show that in certain high-grade osteosarcomas, immature SSEA-4+ tumor cells represent a subset of tumor-initiating cells (TICs) whose pool size is maintained by mTORC1 activity. mTORC1 supports not only SSEA-4+ cell self-renewal through S6K but also the regeneration of SSEA-4+ TICs by SSEA-4− osteosarcoma cell dedifferentiation. Mechanistically, active mTORC1 is required to prevent a likely upregulation of the cell-cycle inhibitor p27 independently of p53 or Rb activation, which otherwise effectively drives the terminal differentiation of SSEA-4− osteosarcoma cells at the expense of dedifferentiation. Thus, mTORC1 is shown to critically regulate the retention of tumorigenicity versus differentiation in discrete differentiation phases in SSEA-4+ TICs and their progeny. PMID:25853231

  13. Recycling of an electric arc furnace flue dust to obtain high grade ZnO.

    PubMed

    Ruiz, Oscar; Clemente, Carmen; Alonso, Manuel; Alguacil, Francisco Jose

    2007-03-01

    The production of steel in electric arc furnace (EAF) generates a by-product called EAF dusts. These steelmaking flue dusts are classified in most industrialized countries as hazardous residues because the heavy metals contained in them, tend to leach under slightly acidic rainfall conditions. However, and at the same time they contain zinc species which can be used as a source to obtain valuable by-products. The present investigation shows results on the processing of an EAF flue dust using ammonium carbonate solutions. Once zinc is dissolved: ZnO + 4NH3 + H2O --> Zn(NH3)4(2+) + 2OH- with other impurities (i.e. cadmium and copper), these are eliminated from the zinc solution via cementation with metallic zinc. The purified zinc solution was evaporated (distilled) until precipitation of a zinc carbonate species, which then was calcined to yield a zinc oxide of a high grade. For the unattacked dust residue from the leaching operation, mainly composed of zinc ferrite, several options can be considered: back-recycling to the furnace, further treatment by sodium hydroxide processing or a more safely dumping due to its relatively inertness. PMID:16876937

  14. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.

    PubMed

    Walsh, Kyle M; Codd, Veryan; Smirnov, Ivan V; Rice, Terri; Decker, Paul A; Hansen, Helen M; Kollmeyer, Thomas; Kosel, Matthew L; Molinaro, Annette M; McCoy, Lucie S; Bracci, Paige M; Cabriga, Belinda S; Pekmezci, Melike; Zheng, Shichun; Wiemels, Joseph L; Pico, Alexander R; Tihan, Tarik; Berger, Mitchell S; Chang, Susan M; Prados, Michael D; Lachance, Daniel H; O'Neill, Brian Patrick; Sicotte, Hugues; Eckel-Passow, Jeanette E; van der Harst, Pim; Wiencke, John K; Samani, Nilesh J; Jenkins, Robert B; Wrensch, Margaret R

    2014-07-01

    Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between LTL and both this new risk locus and other previously established risk loci for glioma using data from a recent GWAS of LTL (n = 37,684 individuals). Alleles associated with glioma risk near TERC and TERT were strongly associated with longer LTL (P = 5.5 × 10(-20) and 4.4 × 10(-19), respectively). In contrast, risk-associated alleles near RTEL1 were inconsistently associated with LTL, suggesting the presence of distinct causal alleles. No other risk loci for glioma were associated with LTL. The identification of risk alleles for glioma near TERC and TERT that also associate with telomere length implicates telomerase in gliomagenesis. PMID:24908248

  15. Effect of Nb on the dynamic recrystallization behavior of high-grade pipeline steels

    NASA Astrophysics Data System (ADS)

    Niu, Tao; Kang, Yong-Lin; Gu, Hong-Wei; Yin, Yu-Qun; Qiao, Ming-Liang; Jiang, Jin-Xing

    2010-12-01

    The dynamic recrystallization (DRX) behavior of high-grade X80/X100 pipeline steels with different Nb contents was investigated through single pass compression experiment using a Gleeble 1500 thermomechanical simulator. By the regression of stress-strain data obtained in the experiment, the deformation activation energy of DRX was identified, and the critical strain was calculated with the Poliak-Jonas (P-J) method. Based on the analysis, the occurrence condition and kinetics of DRX were determined. The results show that as the Nb content increases from 0.08wt% to 0.095wt%, the activation energy of recrystallization raises from 365 to 395 kJ/mol. The critical strain of DRX can be determined more accurately by the P-J method, and the ratios of critical strain to peak strain of X80 and X100 pipeline steels are 0.51 and 0.49, respectively, which are similar to the results achieved by other researchers and calculated with empirical formulae.

  16. Versican isoform V1 regulates proliferation and migration in high-grade gliomas.

    PubMed

    Onken, Julia; Moeckel, Sylvia; Leukel, Petra; Leidgens, Verena; Baumann, Fusun; Bogdahn, Ulrich; Vollmann-Zwerenz, Arabel; Hau, Peter

    2014-10-01

    Versican is a large chondroitin sulphate proteoglycan produced by several tumor cell types, including high-grade gliomas. Increased expression of distinct versican isoforms in the extracellular matrix plays a role in tumor cell growth, adhesion and migration. We have recently shown that transforming growth factor (TGF-beta)2, an important modulator of glioma invasion, interacts with versican isoforms V0/V1 during malignant progression of glioma in vitro. However, the distinct subtype of versican that modulates these effects could not be specified. Here, we show that transient down-regulation of V1 by siRNA leads to a significant reduction of proliferation and migration in glioblastoma cell lines and glioblastoma progenitor cells, whereas tumor cell attachment stays unaffected. We conclude that V1 plays a predominant role in modulating central pathophysiological mechanisms as proliferation and migration in glioblastoma. Considering that TGF-beta is a master regulator of glioma pathophysiology, and that V0/1 is induced by TGF-beta2, therapeutic regulation of V1 may induce meaningful effects on glioma cell migration not only in vitro, but also in vivo. PMID:25064688

  17. Recurrence patterns in patients with high-grade glioma following temozolomide-based chemoradiotherapy

    PubMed Central

    Zhou, Xiaofeng; Liao, Xiaofang; Zhang, Bicheng; He, Huijuan; Shui, Yongjie; Xu, Wenhong; Jiang, Chaogen; Shen, Li; Wei, Qichun

    2016-01-01

    There is currently no consensus regarding the optimal radiation volume for high-grade glioma (HGG). The brain volume irradiated is associated with the extent of radiation neurotoxicity. When reducing the treatment volume, the risk of geographic tumor miss should be considered. In such cases, the recurrence patterns and, particularly, the rate of marginal tumor recurrence, are important indices for determining the optimal radiation volume. In the present study, a smaller-target delineation protocol with limited margins was adopted. The postoperative enhancing tumor and resection cavity were defined as gross tumor volume (GTV); 1 and 2 cm were added to the GTV to create clinical target volume (CTV1 and CTV2), which received 60 and 54 Gy, respectively. At a median follow-up of 14 months, 54 HGG patients developed tumor recurrence. The median overall and progression-free survival were 14 and 10.5 months, respectively. A total of 34 patients developed central recurrence, 8 presented with in-field recurrence, 2 developed marginal recurrence, 2 had distant recurrence and 11 patients developed cerebrospinal fluid dissemination, 2 of whom developed central recurrence, with 1 patient simultaneously developing marginal recurrence. Local recurrence (central and in-field) was found to be the main recurrence pattern. As the rate of marginal recurrence was low (<5%), it appears that the smaller irradiated volume in the present study was appropriate. However, clinical trials investigating limited irradiation volume are required to validate our findings. PMID:27446566

  18. Clinical trial end points for high-grade glioma: the evolving landscape.

    PubMed

    Reardon, David A; Galanis, Evanthia; DeGroot, John F; Cloughesy, Timothy F; Wefel, Jeffrey S; Lamborn, Kathleen R; Lassman, Andrew B; Gilbert, Mark R; Sampson, John H; Wick, Wolfgang; Chamberlain, Marc C; Macdonald, David R; Mehta, Minesh P; Vogelbaum, Michael A; Chang, Susan M; Van den Bent, Martin J; Wen, Patrick Y

    2011-03-01

    To review the strengths and weaknesses of primary and auxiliary end points for clinical trials among patients with high-grade glioma (HGG). Recent advances in outcome for patients with newly diagnosed and recurrent HGG, coupled with the development of multiple promising therapeutics with myriad antitumor actions, have led to significant growth in the number of clinical trials for patients with HGG. Appropriate clinical trial design and the incorporation of optimal end points are imperative to efficiently and effectively evaluate such agents and continue to advance outcome. Growing recognition of limitations weakening the reliability of traditional clinical trial primary end points has generated increasing uncertainty of how best to evaluate promising therapeutics for patients with HGG. The phenomena of pseudoprogression and pseudoresponse have made imaging-based end points, including overall radiographic response and progression-free survival, problematic. Although overall survival is considered the "gold-standard" end point, recently identified active salvage therapies such as bevacizumab may diminish the association between presalvage therapy and overall survival. Finally, advances in imaging as well as the assessment of patient function and well being have strengthened interest in auxiliary end points assessing these aspects of patient care and outcome. Better appreciation of the strengths and limitations of primary end points will lead to more effective clinical trial strategies. Technical advances in imaging as well as improved survival for patients with HGG support the further development of auxiliary end points evaluating novel imaging approaches as well as measures of patient function and well being. PMID:21310734

  19. Clinical trial end points for high-grade glioma: the evolving landscape*

    PubMed Central

    Reardon, David A.; Galanis, Evanthia; DeGroot, John F.; Cloughesy, Timothy F.; Wefel, Jeffrey S.; Lamborn, Kathleen R.; Lassman, Andrew B.; Gilbert, Mark R.; Sampson, John H.; Wick, Wolfgang; Chamberlain, Marc C.; Macdonald, David R.; Mehta, Minesh P.; Vogelbaum, Michael A.; Chang, Susan M.; Van den Bent, Martin J.; Wen, Patrick Y.

    2011-01-01

    To review the strengths and weaknesses of primary and auxiliary end points for clinical trials among patients with high-grade glioma (HGG). Recent advances in outcome for patients with newly diagnosed and recurrent HGG, coupled with the development of multiple promising therapeutics with myriad antitumor actions, have led to significant growth in the number of clinical trials for patients with HGG. Appropriate clinical trial design and the incorporation of optimal end points are imperative to efficiently and effectively evaluate such agents and continue to advance outcome. Growing recognition of limitations weakening the reliability of traditional clinical trial primary end points has generated increasing uncertainty of how best to evaluate promising therapeutics for patients with HGG. The phenomena of pseudoprogression and pseudoresponse have made imaging-based end points, including overall radiographic response and progression-free survival, problematic. Although overall survival is considered the “gold-standard” end point, recently identified active salvage therapies such as bevacizumab may diminish the association between presalvage therapy and overall survival. Finally, advances in imaging as well as the assessment of patient function and well being have strengthened interest in auxiliary end points assessing these aspects of patient care and outcome. Better appreciation of the strengths and limitations of primary end points will lead to more effective clinical trial strategies. Technical advances in imaging as well as improved survival for patients with HGG support the further development of auxiliary end points evaluating novel imaging approaches as well as measures of patient function and well being. PMID:21310734

  20. Longitudinal Impact of Two Universal Preventive Interventions in First Grade on Educational Outcomes in High School.

    PubMed

    Bradshaw, Catherine P; Zmuda, Jessika H; Kellam, Sheppard G; Ialongo, Nicholas S

    2009-11-01

    This study examined the longitudinal effects of 2 first-grade universal preventive interventions on academic outcomes (e.g., achievement, special education service use, graduation, postsecondary education) through age 19 in a sample of 678 urban, primarily African American children. The classroom-centered intervention combined the Good Behavior Game (H. H. Barrish, Saunders, & Wolfe, 1969) with an enhanced academic curriculum, whereas a second intervention, the Family-School Partnership, focused on promoting parental involvement in educational activities and bolstering parents' behavior management strategies. Both programs aimed to address the proximal targets of aggressive behavior and poor academic achievement. Although the effects varied by gender, the classroom-centered intervention was associated with higher scores on standardized achievement tests, greater odds of high school graduation and college attendance, and reduced odds of special education service use. The intervention effects of the Family-School Partnership were in the expected direction; however, only 1 effect reached statistical significance. The findings of this randomized controlled trial illustrate the long-term educational impact of preventive interventions in early elementary school. PMID:23766545