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Sample records for 14-0551 cambridge ma

  1. 75 FR 38128 - Sensata Technologies MA, Inc., Power Controls Division, Formerly Known As Airpax Corp., Cambridge...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... Employment and Training Administration Sensata Technologies MA, Inc., Power Controls Division, Formerly Known..., 2010, applicable to workers of Sansata Technologies MA, Incorporated, Power Controls Division, formerly... under the control of the Cambridge, Maryland location of Sensata Technologies MA, Incorporated,...

  2. EDITORIAL: Proceedings of the 12th Gravitational Wave Data Analysis Workshop (GWDAW 12), Cambridge, MA, USA, 13 16 December 2007

    NASA Astrophysics Data System (ADS)

    Hughes, S.; Katsavounidis, E.

    2008-09-01

    It was a great pleasure and an honor for us to host the 12th Gravitational Wave Data Analysis Workshop (GWDAW) at MIT and the LIGO Laboratory in Cambridge, Massachusetts, the place where this workshop series started in 1996. This time the conference was held at the conference facilities of the Royal Sonesta Hotel in Cambridge from 13 16 December, 2007. This 12th GWDAW found us with the ground interferometers having just completed their most sensitive search for gravitational waves and as they were starting their preparation to bring online and/or propose more sensitive instruments. Resonant mass detectors continued to observe the gravitational wave sky with instruments that have been operating now for many years. LISA, the Laser Interferometer Space Antenna, was recently reviewed by NASA's Beyond Einstein Program Assessment Committee (BEPAC) convened by the National Research Council (NRC) and found that 'on purely scientific grounds LISA is the mission that is the most promising and least scientifically risky…thus, the committee gave LISA its highest scientific ranking'. Even so, JDEM, the Joint Dark Energy Mission, was identified to go first, with LISA following a few years after. New methods, analysis ideas, results from the analysis of data collected by the instruments, as well as Mock Data Challenges for LISA were reported in this conference. While data from the most recent runs of the instruments are still being analyzed, the first upper limit results show how even non-detection statements can be interesting astrophysics. Beyond these traditional aspects of GWDAW though, for the first time in this workshop we tried to bring the non-gravitational wave physics and astronomy community on board in order to present, discuss and propose ways to work together as we pursue the first detection of gravitational waves and as we hope to transition to gravitational wave astronomy in the near future. Overview talks by colleagues leading observations in the electromagnetic

  3. Experiencing Entrepreneurship at Cambridge.

    ERIC Educational Resources Information Center

    Brown, Richard A.; Puddick, Ruth

    2002-01-01

    In a pilot program, Cambridge University students undertook project-based work placements in entrepreneurial organizations. Although small and medium-sized businesses recognize the benefits of such collaborations, few had taken placements before. An efficient communication process with employers was critical. (Contains 15 references.) (SK)

  4. The RGO, Cambridge.

    NASA Astrophysics Data System (ADS)

    Henbest, N.

    1986-08-01

    Despite intense lobbying by astronomers, MPs, local government officers and peers of the realm, the Science and Engineering Research Council (SERC) has confirmed its decision to move the Royal Greenwich Observatory from Herstmonceux. They have chosen Cambridge as the RGO's new home.

  5. The Cambridge Structural Database.

    PubMed

    Groom, Colin R; Bruno, Ian J; Lightfoot, Matthew P; Ward, Suzanna C

    2016-04-01

    The Cambridge Structural Database (CSD) contains a complete record of all published organic and metal-organic small-molecule crystal structures. The database has been in operation for over 50 years and continues to be the primary means of sharing structural chemistry data and knowledge across disciplines. As well as structures that are made public to support scientific articles, it includes many structures published directly as CSD Communications. All structures are processed both computationally and by expert structural chemistry editors prior to entering the database. A key component of this processing is the reliable association of the chemical identity of the structure studied with the experimental data. This important step helps ensure that data is widely discoverable and readily reusable. Content is further enriched through selective inclusion of additional experimental data. Entries are available to anyone through free CSD community web services. Linking services developed and maintained by the CCDC, combined with the use of standard identifiers, facilitate discovery from other resources. Data can also be accessed through CCDC and third party software applications and through an application programming interface.

  6. The Cambridge Structural Database

    PubMed Central

    Groom, Colin R.; Bruno, Ian J.; Lightfoot, Matthew P.; Ward, Suzanna C.

    2016-01-01

    The Cambridge Structural Database (CSD) contains a complete record of all published organic and metal–organic small-molecule crystal structures. The database has been in operation for over 50 years and continues to be the primary means of sharing structural chemistry data and knowledge across disciplines. As well as structures that are made public to support scientific articles, it includes many structures published directly as CSD Communications. All structures are processed both computationally and by expert structural chemistry editors prior to entering the database. A key component of this processing is the reliable association of the chemical identity of the structure studied with the experimental data. This important step helps ensure that data is widely discoverable and readily reusable. Content is further enriched through selective inclusion of additional experimental data. Entries are available to anyone through free CSD community web services. Linking services developed and maintained by the CCDC, combined with the use of standard identifiers, facilitate discovery from other resources. Data can also be accessed through CCDC and third party software applications and through an application programming interface. PMID:27048719

  7. The Cambridge Experimentation Review Board

    ERIC Educational Resources Information Center

    Bulletin of the Atomic Scientists, 1977

    1977-01-01

    Reproduced is the report made by a citizens' group in Cambridge, Massachusetts and presented to the city council that outlines safety regulations for the conduct of recombinant DNA research at Harvard University and the Massachusetts Institute of Technology. (CS)

  8. Time-Resolved Photoacoustic and Photothermal Measurements on Surfaces, Thin Films and Multilayer Assemblies.

    NASA Astrophysics Data System (ADS)

    Rogers, John Ashley

    1995-01-01

    Various laser-based methods are used to evaluate important properties in a number of different technologically and scientifically interesting materials. An industrially viable and user-friendly portable apparatus based on the most powerful of these methods is described and demonstrated. Research presented as part of a comprehensive business plan indicates an extensive market for this device. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  9. Revision Planned for the Cambridge Latin Course.

    ERIC Educational Resources Information Center

    Sebesta, Judith Lynn

    1980-01-01

    Summarizes a discussion on the revision of the Cambridge Latin Course (CLC) held during the 1980 ACL Institute at the University of New Hampshire by CLC users and Cambridge University Press representatives. Emphasizes suggestions by users on grammar instruction strategies better suited to American students' needs. (MES)

  10. Cambridge Elementary students enjoy gift of computers

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Children at Cambridge Elementary School, Cocoa, Fla., eagerly unwrap computer equipment donated by Kennedy Space Center. Cambridge is one of 13 Brevard County schools receiving 81 excess contractor computers thanks to an innovative educational outreach project spearheaded by the Nasa k-12 Education Services Office at ksc. Behind the children is Jim Thurston, a school volunteer and retired employee of USBI, who shared in the project. The Astronaut Memorial Foundation, a strategic partner in the effort, and several schools in rural Florida and Georgia also received refurbished computers as part of the year-long project. Ksc employees put in about 3,300 volunteer hours to transform old, excess computers into upgraded, usable units. A total of $90,000 in upgraded computer equipment is being donated.

  11. 76 FR 13665 - Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... certification to include workers leased from Action Total Staffing working on-site at the Cambridge, Ohio... Employment and Training Administration Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH; Amended Certification Regarding Eligibility To Apply for...

  12. Alchemy in Cambridge. An Annotated Catalogue of Alchemical Texts and Illustrations in Cambridge Repositories.

    PubMed

    Timmermann, Anke

    2015-01-01

    Alchemy in Cambridge captures the alchemical content of 56 manuscripts in Cambridge, in particular the libraries of Trinity College, Corpus Christi College and St John's College, the University Library and the Fitzwilliam Museum. As such, this catalogue makes visible a large number of previously unknown or obscured alchemica. While extant bibliographies, including those by M.R. James a century ago, were compiled by polymathic bibliographers for a wide audience of researchers, Alchemy in Cambridge benefits from the substantial developments in the history of alchemy, bibliography, and related scholarship in recent decades. Many texts are here identified for the first time. Another vital feature is the incorporation of information on alchemical illustrations in the manuscripts, intended to facilitate research on the visual culture of alchemy. The catalogue is aimed at historians of alchemy and science, and of high interest to manuscript scholars, historians of art and historians of college and university libraries.

  13. The Cambridge Guide to the Solar System

    NASA Astrophysics Data System (ADS)

    Lang, Kenneth R.

    2003-10-01

    The Cambridge Guide to the Solar System provides a comprehensive, funamental, and up-to-date description of the solar system. It is written in a concise, light and uniform style, without being unnecessarily weighted down with specialized materials or the variable writing of multiple authors. It is filled with vital facts and information for astronomers of all types and for anyone with a scientific interest in the Earth, our Moon, all the other planets and their satellites, and related topics such as asteroids, comets, meteorites and meteors. The language, style, ideas and profuse illustrations will attract the general reader as well as professionals. A thorough report for general readers, it includes much compact reference data. Metaphors, similes and analogies will be of immense help to the lay person or non-science student, and they add to the enjoyment of the material. Vignettes containing historical, literary and even artistic material make this book unusual and interesting, and enhance its scientific content. Kenneth Lang is professor of astronomy in the Physics and Astronomy Department at Tufts University. He is the author of several astrophysics books, including The Sun from Space (Springer Verlag, 2000), Astrophysical Formulae: Radiation, Gas Processes, and High Energy Physics (Springer Verlag, 1999), Sun, Earth and Sky (Copernicus Books, 1997), Astrophysical Data: Planets and Stars (Springer Verlag, 1993), and Wanderers in Space: Exploration and Discovery in the Solar System (Cambridge, 1991),

  14. The Whipple Museum and Cavendish Laboratory, Cambridge

    NASA Astrophysics Data System (ADS)

    Pippard, Brian

    The Whipple Museum is part of the History and Philosophy of Science Department in the University of Cambridge. It is on your right as soon as you enter Free School Lane from Pembroke Street, and is normally open between 1:30 and 4:30 P.M. on weekdays. The main room, a hall with hammer-beam roof, is a relic of Stephen Perse’s school (1624) now flourishing elsewhere in the city. It houses a large collection of mathematical, physical and astronomical instruments — abaci, Napier’s bones, slide rules; sextants and other surveying instruments; telescopes, compasses and pocket sundials (especially of ivory from Nuremberg 1500-1700); and a Grand Orrery by George Adams (1750). The gallery of a second room is used for special exhibitions, often of items from the well-stocked store. Some specialist catalogues have been compiled and are on sale.

  15. The Cambridge Illustrated History of Astronomy

    NASA Astrophysics Data System (ADS)

    Hoskin, Michael

    Expertly written and lavishly illustrated, The Cambridge Illustrated History of Astronomy offers a unique account of astronomical theory and practice from antiquity to the present day. How did Moslems of the Middle Ages use astronomy to calculate the direction of Mecca from far-flung corners of the Islamic world? Who was the only ancient Greek to suspect that the earth might revolve around the sun? How did Christopher Columbus abuse his knowledge of a lunar eclipse predicted by an astronomical almanac? Packed with anecdotes and intriguing detail, this book describes how we observed the sky and interpreted what we saw at different periods of history; how this influenced our beliefs and mythology; and how great astronomers contributed to what we now know. The result is a lively and highly visual history of astronomy - a compelling read for specialists and non-specialists alike.

  16. Teachers Learning: Professional Development and Education. Cambridge Education Research Series

    ERIC Educational Resources Information Center

    McLaughlin, Colleen, Ed.

    2012-01-01

    "Teachers Learning: Professional Development and Education" is part of The Cambridge Education Research series, edited by senior colleagues at the University of Cambridge Faculty of Education, which has a longstanding tradition of involvement in high quality, innovative teacher education and continuing professional development.…

  17. Teacher's Guide to Accompany the Cambridge Latin Course. Tentative Edition.

    ERIC Educational Resources Information Center

    Masciantonio, Rudolph

    This guide is designed to assist teachers using the "Cambridge Latin Course," a multimedia instructional system developed in the United Kingdom which can be adapted to the needs of pupils of varying backgrounds, ages, and abilities. The Guide focuses on Unit I, the first level of the Cambridge materials. The materials are especially suited to…

  18. 77 FR 64143 - Manufacturer of Controlled Substances; Notice of Registration; Cambridge Isotope Lab

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Enforcement Administration Manufacturer of Controlled Substances; Notice of Registration; Cambridge Isotope..., Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application by renewal to the... registration of Cambridge Isotope Lab to manufacture the listed basic class of controlled substance...

  19. Mobile robots II; Proceedings of the Meeting, Cambridge, MA, Nov. 5, 6, 1987

    SciTech Connect

    Wolfe, W.J.; Chun, W.H.

    1988-01-01

    Topics discussed are autonomous vehicle guidance, three-dimensional systems, the Mars rover, motion analysis, and planning and navigation. Particular papers are presented on a real-time system architecture for a mobile robot, distributed scene analysis for autonomous road vehicle guidance, the vision system for a Mars rover, the recovery of motion parameters using optical flow, and Prolog-based world models for mobile robot navigation.

  20. Our Public Intellectual: Matthew Battles--Houghton Library, Harvard University, Cambridge, MA

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    Many people take for granted the tools of the librarian's trade: typography, books, even the idea of a library. But when Matthew Battles looks at these things, he sees responses that evolved to meet human needs and wants to know more. What purposes were these tools put to and what do they tell people about the culture that produced them? What does…

  1. Intelligent robots and computer vision; Proceedings of the Meeting, Cambridge, MA, Nov. 2-6, 1987

    SciTech Connect

    Casasent, D.P.; Hall, E.L.

    1988-01-01

    Topics discussed include pattern recognition, image processing, sensors, model-based object recognition, image understanding, artificial neural systems, and three-dimensional object recognition. Consideration is also given to stereo image processing, optical flow, intelligent control, vision-aided automated control systems, architectures and software, and industrial applications.

  2. Mobile robots III; Proceedings of the Meeting, Cambridge, MA, Nov. 10, 11, 1988

    SciTech Connect

    Wolfe, W.J.

    1989-01-01

    Topics discussed include path planning, terrain classification, planetary rovers, navigation, architecture and control, three-dimensional sensing, and behavior specification. Particular papers are presented on a minimum path algorithm among three-dimensional polyhedral objects, parallel off-road perception processing on the autonomous land vehicle, hazard avoidance for a Mars rover, color vision for road following, a pipeline architecture for near real-time stereo range detection, a computational structure for enforcing reactive behavior in a mobile robot, and homeostatic control for a mobile robot.

  3. MEETING AT CAMBRIDGE, MA: GENE EXPRESSION IN NORMAL HUMAN KERATINOCYTES MODULATED BY TRIVALENT ARSENICALS

    EPA Science Inventory

    Arsenic exposure has been correlated with the development of several human cancers including those found in the skin, lung, liver, kidney and urinary bladder. Humans are generally exposed to inorganic forms of arsenic, which may be inhaled or ingested. Arsenic forms mono- and d...

  4. Artificial Pancreas Project at Cambridge 2013.

    PubMed

    Hovorka, R

    2015-08-01

    The development and clinical testing of closed-loop systems (the artificial pancreas) is underpinned by advances in continuous glucose monitoring and benefits from concerted academic and industry collaborative efforts. This review describes the progress of the Artificial Pancreas Project at the University of Cambridge from 2006 to 2014. Initial studies under controlled laboratory conditions, designed to collect representative safety and performance data, were followed by short to medium free-living unsupervised outpatient studies demonstrating the safety and efficacy of closed-loop insulin delivery using a model predictive control algorithm. Accompanying investigations included assessment of the psychosocial impact and key factors affecting glucose control such as insulin kinetics and glucose absorption. Translation to other disease conditions such as critical illness and Type 2 diabetes took place. It is concluded that innovation of iteratively enhanced closed-loop systems will provide tangible means to improve outcomes and quality of life in people with Type 1 diabetes and their families in the next decade.

  5. 76 FR 12729 - Cambridge Environmental Inc; Transfer of Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... AGENCY Cambridge Environmental Inc; Transfer of Data AGENCY: Environmental Protection Agency (EPA... evaluating assessments. This includes evaluating the applicability of the data and methods used in the... pesticide data or risk. The contractor may develop policy options for evaluation and consideration by...

  6. EVALUATION OF HEADSTART EDUCATIONAL PROGRAM IN CAMBRIDGE, MASSACHUSETTS. FINAL REPORT.

    ERIC Educational Resources Information Center

    PORTER, PHILIP J.; AND OTHERS

    BEGINNING WITH A REVIEW OF THE NURSERY SCHOOL MOVEMENT (FROEBEL, MONTESSORI, AND MCMILLAN,) THIS EVALUATION RELATES THE HISTORICAL MATERIAL TO HEAD START, SPECIFICALLY IN CAMBRIDGE MASS. DURING THE SUMMER OF 1965, MATCHED GROUPS OF 33 HEAD START CHILDREN AND 33 NON-HEAD START CHILDREN (CONTROL GROUP) WERE STUDIED. SCHOOL PRE-REGISTRATION LISTS…

  7. Cambridge Health's outreach earns alliance an AHA NOVA Award.

    PubMed

    Rees, Tom

    2005-01-01

    Cambridge Health Alliance, (CHA), Somerville, Mass., has been named for one of the five NOVA Awards given this year by the American Hospital Association. It is recognized for leading a program to improve community health by extending help to low-income and uninsured children and adults, as well as to the chronically ill and racial and ethnic minorities.

  8. The Cambridge Primary Review: A Reply to R. J. Campbell

    ERIC Educational Resources Information Center

    Armstrong, Michael

    2010-01-01

    The author was disappointed by R. J. Campbell's sour critique of the Cambridge Primary Review in "FORUM" Volume 52 Number 1 2010. His description of the Review's proposals on curriculum and pedagogy as "backward-looking, cumbersome and partial" is such a bizarre misjudgement that it calls for some response. The author comments in turn on R. J.…

  9. 77 FR 38086 - Manufacturer of Controlled Substances, Notice of Application, Cambridge Isotope Lab

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application, Cambridge Isotope Lab... 7, 2012, Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application...

  10. 78 FR 52802 - Manufacturer of Controlled Substances; Notice of Application; Cambridge Isotope Lab

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cambridge Isotope Lab... 01, 2013, Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application...

  11. The work of the Animal Research Station, Cambridge.

    PubMed

    Polge, Chris

    2007-06-01

    This paper traces the history of the Animal Research Station, Cambridge from its establishment in 1932 to its closure in 1986. The author worked there for forty years and was Director from 1979. Originally set up as a field station for Cambridge University's School of Agriculture, the Station was expanded after World War II as the Agricultural Research Council's Unit of Animal Reproduction. Beginning with semen and artificial insemination, research at the Station soon embraced superovulation and embryo transfer in farm animals. Many other technologies were also developed here, including IVF in pigs, cloning by nuclear transplantation of early embryonic cells, and the first genetically modified farm animals in Britain. This account recalls the Directors of the Station and their research teams together with details of their pioneering contribution to reproductive biology.

  12. [MaRS Project

    NASA Technical Reports Server (NTRS)

    Aruljothi, Arunvenkatesh

    2016-01-01

    The Space Exploration Division of the Safety and Mission Assurances Directorate is responsible for reducing the risk to Human Space Flight Programs by providing system safety, reliability, and risk analysis. The Risk & Reliability Analysis branch plays a part in this by utilizing Probabilistic Risk Assessment (PRA) and Reliability and Maintainability (R&M) tools to identify possible types of failure and effective solutions. A continuous effort of this branch is MaRS, or Mass and Reliability System, a tool that was the focus of this internship. Future long duration space missions will have to find a balance between the mass and reliability of their spare parts. They will be unable take spares of everything and will have to determine what is most likely to require maintenance and spares. Currently there is no database that combines mass and reliability data of low level space-grade components. MaRS aims to be the first database to do this. The data in MaRS will be based on the hardware flown on the International Space Stations (ISS). The components on the ISS have a long history and are well documented, making them the perfect source. Currently, MaRS is a functioning excel workbook database; the backend is complete and only requires optimization. MaRS has been populated with all the assemblies and their components that are used on the ISS; the failures of these components are updated regularly. This project was a continuation on the efforts of previous intern groups. Once complete, R&M engineers working on future space flight missions will be able to quickly access failure and mass data on assemblies and components, allowing them to make important decisions and tradeoffs.

  13. Applications of the Cambridge Structural Database in chemical education.

    PubMed

    Battle, Gary M; Ferrence, Gregory M; Allen, Frank H

    2010-10-01

    The Cambridge Structural Database (CSD) is a vast and ever growing compendium of accurate three-dimensional structures that has massive chemical diversity across organic and metal-organic compounds. For these reasons, the CSD is finding significant uses in chemical education, and these applications are reviewed. As part of the teaching initiative of the Cambridge Crystallographic Data Centre (CCDC), a teaching subset of more than 500 CSD structures has been created that illustrate key chemical concepts, and a number of teaching modules have been devised that make use of this subset in a teaching environment. All of this material is freely available from the CCDC website, and the subset can be freely viewed and interrogated using WebCSD, an internet application for searching and displaying CSD information content. In some cases, however, the complete CSD System is required for specific educational applications, and some examples of these more extensive teaching modules are also discussed. The educational value of visualizing real three-dimensional structures, and of handling real experimental results, is stressed throughout.

  14. [Clinical usefulness and psychometric properties of the Cambridge Behavioural Inventory].

    PubMed

    Fernandez-Martinez, R; Kokoulina, E; Carballido-Araujo, E; Garcia-Fuertes, I; Gutierrez-Martinez, O; Santiago-Lopez, F; Vazquez-Batan, P

    2016-11-16

    Introduccion. Un area importante de la evaluacion neuropsicologica son los sintomas psicologicos y conductuales. El inventario conductual de CambridgeCambridge Behavioural Inventory (CBI)– es una medida de autoinforme dirigida a allegados que recoge una amplia variedad de sintomas conductuales que pueden darse en el curso de las enfermedades neurologicas. El principal objetivo del estudio es comprobar la utilidad clinica de su adaptacion al castellano. Sujetos y metodos. El CBI fue cumplimentado por 215 allegados de pacientes remitidos desde los servicios de neurologia y psiquiatria. Se compararon los perfiles del CBI de cuatro grupos de pacientes formados sobre la base de sus principales caracteristicas clinicas, datos psicometricos, pruebas de imagen y juicio clinico del profesional solicitante del estudio neuropsicologico. Resultados. La mayoria de las escalas (10 de 13) del CBI tuvo valores de consistencia interna aceptables, y las escalas de memoria y atencion/orientacion, correlaciones elevadas con medidas objetivas de memoria y orientacion temporal. Los perfiles del CBI de los grupos de pacientes con distintas condiciones (trastorno organico de la memoria, trastorno funcional de la memoria, variante conductual de demencia frontotemporal y enfermedad de Alzheimer) fueron consistentes con sus principales caracteristicas. Conclusiones. El CBI es un instrumento psicometricamente fiable y con adecuada validez convergente y discriminante que puede ser util en el proceso de evaluacion neuropsicologica, aportando informacion relevante no solo sobre el funcionamiento cognitivo y las capacidades funcionales, sino tambien sobre los sintomas conductuales y psicologicos de los pacientes con trastornos cognitivos.

  15. Applications of the Cambridge Structural Database in chemical education1

    PubMed Central

    Battle, Gary M.; Ferrence, Gregory M.; Allen, Frank H.

    2010-01-01

    The Cambridge Structural Database (CSD) is a vast and ever growing compendium of accurate three-dimensional structures that has massive chemical diversity across organic and metal–organic compounds. For these reasons, the CSD is finding significant uses in chemical education, and these applications are reviewed. As part of the teaching initiative of the Cambridge Crystallographic Data Centre (CCDC), a teaching subset of more than 500 CSD structures has been created that illustrate key chemical concepts, and a number of teaching modules have been devised that make use of this subset in a teaching environment. All of this material is freely available from the CCDC website, and the subset can be freely viewed and interrogated using WebCSD, an internet application for searching and displaying CSD information content. In some cases, however, the complete CSD System is required for specific educational applications, and some examples of these more extensive teaching modules are also discussed. The educational value of visualizing real three-dimensional structures, and of handling real experimental results, is stressed throughout. PMID:20877495

  16. Optics, illumination, and image sensing for machine vision III; Proceedings of the Meeting, Cambridge, MA, Nov. 8, 9, 1988

    SciTech Connect

    Svetkoff, D.J.

    1989-01-01

    Various papers on optics, illumination, and image sensing for machine vision are presented. Some of the optics discussed include: illumination and imaging of moving objects, strobe illumination systems for machine vision, optical collision timer, new electrooptical coordinate measurement system, flexible and piezoresistive touch sensing array, selection of cameras for machine vision, custom fixed-focal length versus zoom lenses, performance of optimal phase-only filters, minimum variance SDF design using adaptive algorithms, Ho-Kashyap associative processors, component spaces for invariant pattern recognition, grid labeling using a marked grid, illumination-based model of stochastic textures, color-encoded moire contouring, noise measurement and suppression in active 3-D laser-based imaging systems, structural stereo matching of Laplacian-of-Gaussian contour segments for 3D perception, earth surface recovery from remotely sensed images, and shape from Lambertian photometric flow fields.

  17. Advances in cryogenic engineering. Volume 31; Proceedings of the Cryogenic Engineering Conference, MIT, Cambridge, MA, Aug. 12-16, 1985

    NASA Technical Reports Server (NTRS)

    Fast, R. W. (Editor)

    1986-01-01

    The present conference on the applications of state-of-the-art cryogenic engineering technologies considers topics associated with the development status of the 'Superconducting SuperCollider', superconducting magnetic energy storage methods, large magnets for fusion and other physics researches, cryogenic hardware improvements, and phenomena and applications of superconducting magnet-employing acoustic emission test equipment. Also discussed are design criteria for superconducting magnet stability, heat exchangers and heat transfer to liquid He and N, heat and mass transfer characteristics of He II, refrigeration techniques for magnetic resonance imaging and other small systems, refrigeration for liquefaction and for superconducting fusion as well as for accelerator and generator systems, magnetic refrigeration, cryocooling and refrigeration for space applications, the storage and transfer of cryogenic fluids, the properties of cryogenic liquids, and air liquefaction equipment.

  18. Sensor fusion: Spatial reasoning and scene interpretation; Proceedings of the Meeting, Cambridge, MA, Nov. 7-9, 1988

    NASA Technical Reports Server (NTRS)

    Schenker, Paul S. (Editor)

    1989-01-01

    The present conference discusses topics in the fusion of active and passive sensors, object estimation and verification, three-dimensional representation and knowledge integration, three-dimensional perception from multisensor data, the representation of uncertainty in multisensor fusion, and sensor calibration and registration. Also discussed are the areas of multisensor target detection and classification, multisensor processing architectures, knowledge structures and spatial reasoning, sensory interfaces to telerobotic systems, and navigation with spatial data bases.

  19. Intelligent robots and computer vision; Proceedings of the Fourth Meeting, Cambridge, MA, September 16-20, 1985

    SciTech Connect

    Casasent, D.P.

    1985-01-01

    Papers are presented on feature extraction and pattern recognition for computer vision, image processing for intelligent robotics, robot sensors, and image understanding and artificial intelligence. Topics discussed include optical processing techniques in robotic applications, robot languages and programming, processor architecture for computer vision, and mobile robots. Consideration is given to multisensor fusion, three-dimensional modeling and recognition, intelligent robots applications, and intelligent robot systems.

  20. Intelligent robots and computer vision; Proceedings of the Fifth Meeting, Cambridge, MA, Oct. 28-31, 1986

    SciTech Connect

    Casasent, D.P.

    1987-01-01

    Major topics and new areas of work in intelligent robots and computer vision research are examined. The general topics addressed include: pattern recognition for computer vision, image processing for intelligent robotics, depth and motion in three-dimensional vision, modeling and shape estimation in three-dimensional vision, symbolic processing of visual information, robotic sensors and applications, intelligent control architectures for robot systems, robot languages and programing, human-machine interfaces, systems and architectures for robotics.

  1. Laser research and development in the Northeast; Proceedings of the Meeting, Cambridge, MA, Sept. 16, 17, 1986

    SciTech Connect

    Trainor, D.W.; Chicklis, E.P.

    1987-01-01

    The development and scaling of excimer lasers with emphasis on both electron-beam and discharge pumpings; a chemical means of generating laser action in the visible region; the use of stimulated Raman techniques to improve the beam quality output of systems employing excimer lasers; the research and development of CO/sub 2/ lasers; a CO/sub 2/ laser amplifier for radar applications; medical laser usage; and laser monitors for trace species in environmental and industrial processes are examined. Consideration is given to high power laser research and development for laser energetics; linear and nonlinear frequency converters; 450 nm laser operation in Tm(3+):YLF; alexandrite lasers and their applications; and the performance limitations of vibronic lasers. Topics discussed include the laser ignition of oil spills; the application of laser rangers to submunitions; the design and application of laser intensity stabilizers; and a 535 nm active atomic line filter that uses the Tl metastable state as an absorbing medium.

  2. Fiber optic and laser sensors IV; Proceedings of the Meeting, Cambridge, MA, Sept. 22-24, 1986

    NASA Technical Reports Server (NTRS)

    De Paula, Ramon P. (Editor); Udd, Eric (Editor)

    1987-01-01

    The conference presents papers on industrial uses of fiber optic sensors, point and distributed polarimetric optical fiber sensors, fiber optic electric field sensor technology, micromachined resonant structures, single-mode fibers for sensing applications, and measurement techniques for magnetic field gradient detection. Consideration is also given to electric field meter and temperature measurement techniques for the power industry, the calibration of high-temperature fiber-optic microbend pressure transducers, and interferometric sensors for dc measurands. Other topics include the recognition of colors and collision avoidance in robotics using optical fiber sensors, the loss compensation of intensity-modulating fiber-optic sensors, and an embedded optical fiber strain tensor for composite structure applications.

  3. Assessing the Impact of Arts and Humanities Research at the University of Cambridge. Technical Report

    ERIC Educational Resources Information Center

    Levitt, Ruth; Celia, Claire; Diepeveen, Stephanie; Chonaill, Siobhan Ni; Rabinovich, Lila; Tiessen, Jan

    2010-01-01

    This project for the University of Cambridge and the Arts and Humanities Research Council (AHRC) assesses the impacts of arts and humanities research at the University of Cambridge. Evidence from interviews, a survey of research staff and detailed case studies indicates that these disciplines already have a broad range of impacts. Many of these…

  4. Ma'adim Vallis

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Color image of Ma'adim Vallis region of Mars; north toward top. Image shows the 600-km-long channel that drained into impact crater Gusev. Crater Gusev is about 160 km in diameter. This image is a composite of Viking medium-resolution images in black and white and low-resolution images in color. The image extends from latitude 13 degrees S. to 29 degrees S. and from longitude 180 degrees to 188 degrees; Mercator projection. Ma'adim Vallis is cut into the degraded highlands of Mars and has morphologic characteristics of terrestrial river beds, including the well-developed dentritic tributaries that constitute an integrated river system. However, the junction angles between tributaries commonly show a wide variation, which gives the channel system a more random directional pattern than typical terrestrial drainage networks. Topographic contours suggest a large drainage basin once existed for this channel. Gradients for the channel are high, about 0.007, over the central 300 km of its length; this is about two times that of the upper 450 km of the Colorado River. In places, some tributaries are discontinuous, perhaps indicating burial by more recent material. After the channel breaches Gusev it appears to end within the crater. Termination may have resulted from burial by younger deposits or perhaps the flow percolated into the surface materials and continued underground.

  5. The Cambridge-Cambridge x-ray serendipity survey. 2: Classification of x-ray luminous galaxies

    NASA Technical Reports Server (NTRS)

    Boyle, B. J.; Mcmahon, R. G.; Wilkes, B. J.; Elvis, Martin

    1994-01-01

    We present the results of an intermediate-resolution (1.5 A) spectroscopic study of 17 x-ray luminous narrow emission-line galaxies previously identified in the Cambridge-Cambridge ROSAT Serendipity Survey and the Einstein Extended Medium Sensitivity Survey. Emission-line ratios reveal that the sample is composed of ten Seyfert and seven starburst galaxies. Measured linewidths for the narrow H alpha emission lines lie in the range 170 - 460 km s(exp -1). Five of the objects show clear evidence for asymmetry in the (OIII) lambda 5007 emission-line profile. Broad H alpha emission is detected in six of the Seyfert galaxies, which range in type from Seyfert 1.5 to 2. Broad H beta emission is only detected in one Seyfert galaxy. The mean full width at half maximum for the broad lines in the Seyfert galaxies is FWHM = 3900 +/- 1750 km s(exp -1). Broad (FWHM = 2200 +/- 600 km s(exp -1) H alpha emission is also detected in three of the starburst galaxies, which could originate from stellar winds or supernovae remnants. The mean Balmer decrement for the sample is H alpha / H beta = 3, consistent with little or no reddening for the bulk of the sample. There is no evidence for any trend with x-ray luminosity in the ratio of starburst galaxies to Seyfert galaxies. Based on our previous observations, it is therefore likely that both classes of object comprise approximately 10 percent of the 2 keV x-ray background.

  6. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... Advantage (MA) Organizations § 495.202 Identification of qualifying MA organizations, MA-EPs and MA... in June 2011 (for plan year 2012), MA organizations seeking reimbursement for qualifying MA EPs...

  7. Pion absorption on Xenon in the region of the delta(1232) resonance

    NASA Astrophysics Data System (ADS)

    Gregory, Nikolas Kellogg

    The absorption of π+ mesons at 118, 162, and 239 MeV on Xenon has been studied using the Large Acceptance Detector System (LADS) at the Paul Scherrer Institute in Villigen, Switzerland. LADS has a solid angle coverage of over 98% of 4π steradians and an energy threshold of less than 20 MeV for protons, making it an excellent detector for studying multi- nucleon final states following π+/- absorption. The total absorption cross sections at the three energies are, in millibarns: 602 +/- 140, 772 +/- 150, and 668 +/- 70. In addition, the breakup of the cross section into channels with different numbers of energetic final state nucleons has been determined. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

  8. Dorothy Hodgkin Lecture 2013: Artificial Pancreas Project at Cambridge 2013

    PubMed Central

    Hovorka, R.

    2015-01-01

    The development and clinical testing of closed-loop systems (the artificial pancreas) is underpinned by advances in continuous glucose monitoring and benefits from concerted academic and industry collaborative efforts. This review describes the progress of the Artificial Pancreas Project at the University of Cambridge from 2006 to 2014. Initial studies under controlled laboratory conditions, designed to collect representative safety and performance data, were followed by short to medium free-living unsupervised outpatient studies demonstrating the safety and efficacy of closed-loop insulin delivery using a model predictive control algorithm. Accompanying investigations included assessment of the psychosocial impact and key factors affecting glucose control such as insulin kinetics and glucose absorption. Translation to other disease conditions such as critical illness and Type 2 diabetes took place. It is concluded that innovation of iteratively enhanced closed-loop systems will provide tangible means to improve outcomes and quality of life in people with Type 1 diabetes and their families in the next decade. PMID:25819473

  9. Discovery and utilization of sorghum genes (Ma5/Ma6)

    SciTech Connect

    Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

    2012-11-13

    Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

  10. Global Paleobathymetry for the Cenomanian-Turonian (90 Ma)

    NASA Astrophysics Data System (ADS)

    Goswami, A.; Olson, P.; Hinnov, L. A.; Gnanadesikan, A.

    2014-12-01

    We present a paleo-ocean bathymetry reconstruction for Cenomanian-Turonian (90 Ma) time in a 0.1°x0.1° resolution for use in paleo-climate studies. Age of the ocean floor for the Cenomanian-Turonian (90 Ma) is from Müller et al. (2008 a,b); coastlines are from the PALEOMAP Project (Scotese, 2011). To reconstruct paleo-ocean bathymetry, we use a plate model equation to model depth to basement (Turcotte and Schubert, 2002). We estimate plate model equation parameter values from measurements of modern oceans (Crosby et al., 2006). On top of the depth to basement, we isostatically add a multilayer sediment model derived from area-corrected sediment thickness data (Divins, 2003; Whittaker et al., 2013). Lastly, we parameterize the modern continental shelf, slope, and rise in a "sediment wedge model" to connect the coastline with the closest ocean crust as defined by Müller et al. (2008 a, b). These parameters are defined using empirical relationships obtained from study of modern ocean transects where a complete rifting history is preserved (Atlantic and Southern oceans), and the closest approach of the respective oceanic crust (Müller et al., 2008a,b) to the coastline. We use the modern ocean as a test, comparing maps and cross sections of modern ocean bathymetry modeled using our reconstruction method with that of ETOPO1 (Amante and Eakins, 2009). Adding sea plateaus and seamounts minimize the difference between our modeled bathymetry and ETOPO1. Finally, we also present a comparison of our reconstructed paleo-bathymetry to that of Müller et al. (2008 a,b) for the Cenomanian-Turonian (90 Ma). References: Amante, C., Eakins, B.W., 2009, NOAA Tech. Memo. NESDIS NGDC-24, 19 p. Crosby, A., McKenzie, D., Sclater, J.G., 2006, Geophysical Journal Int. 166.2, 553-573. Divins, D., 2003, NOAA NGDC, Boulder, CO. Müller, R., Sdrolias, M., Gaina, C., Roest, W., 2008b, Geochemistry, Geophysics, Geosystems, 9, Q04006, doi:10.1029/2007GC001743 Müller, R., Sdrolias, M., Gaina

  11. Paleomagnetism of ~635 Ma "Elatina Rhythmites," Reconsidered

    NASA Astrophysics Data System (ADS)

    Raub, T. D.; Raub, T. M.

    2007-12-01

    Extraordinary laminated sand-siltstone of South Australia's synglacial/deglacial Elatina Formation-equivalent at Pichi Richi Pass is an iconic outcrop for paleomagnetists, paleoclimatologists, and astrophysicists. Cyclic- bedded stacks of coarse/fine-grained doublets have been interpreted as rhythmites of semi-diurnal tidal origin in a deep-water delta front environment. Cycle analysis has yielded estimates of Earth's paleorotation and revolution periods and lunar distance. The reported 10 m (interpreted 60 year) record disagrees somewhat with coeval and younger biological "sediment-clocks," and Williams (2000) argues that the sedimentological context and extraordinary preservation of Elatina rhythmites makes that record preferable. A paleomagnetic "synsedimentary fold" test on <8 cm amplitude antiforms from the Pichi Richi Pass rhythmites confirmed low-latitude Neoproterozoic glaciation (Sumner et al., 1987) and inspired the formal "Snowball Earth" hypothesis (Kirschvink, 1989). Repeated study of the Elatina rhythmites (Schmidt and Williams, 1995 and citations therein) has documented NRM essentially equal to ChRM carried by detrital hematite, "locked-in" synchronously with "deformation" of "antiforms" (i.e., within hours to days of deposition). "Synfolding" remanence has been ascribed to superposition of slump-shear and DRM. Anomalously shallow inclination of rhythmites (Sohl et al., 1999) could represent inadequate averaging of ca. 635 Ma geomagnetic secular variation. New measurement of ten stratigraphic sections through rhythmite-bearing facies outside of Pichi Richi Pass supports a distributary environment since rhythmites are expressed in multiple lithologies closely beneath ultimate deglacial, Nuccaleena cap dolostone. At Pichi Richi Pass, a full section of rhythmites approx. 18 meters thick is now documented, supporting a novel magnetostratigraphic collection of 130 samples. It is necessary to re-examine the DRM interpretation of Elatina rhythmite

  12. Water quality in the Cambridge, Massachusetts, drinking-water source area, 2005-8

    USGS Publications Warehouse

    Smith, Kirk P.; Waldron, Marcus C.

    2015-01-01

    During 2005-8, the U.S. Geological Survey, in cooperation with the Cambridge, Massachusetts, Water Department, measured concentrations of sodium and chloride, plant nutrients, commonly used pesticides, and caffeine in base-flow and stormwater samples collected from 11 tributaries in the Cambridge drinking-water source area. These data were used to characterize current water-quality conditions, to establish a baseline for future comparisons, and to describe trends in surface-water quality. The data also were used to assess the effects of watershed characteristics on surface-water quality and to inform future watershed management.

  13. Scaling of X pinches from 1 MA to 6 MA.

    SciTech Connect

    Bland, Simon Nicholas; McBride, Ryan D.; Wenger, David Franklin; Sinars, Daniel Brian; Chittenden, Jeremy Paul; Pikuz, Sergei A.; Harding, Eric; Jennings, Christopher A.; Ampleford, David J.; Yu, Edmund P.; Cuneo, Michael Edward; Shelkovenko, Tatiana A.; Hansen, Stephanie B.

    2010-09-01

    This final report for Project 117863 summarizes progress made toward understanding how X-pinch load designs scale to high currents. The X-pinch load geometry was conceived in 1982 as a method to study the formation and properties of bright x-ray spots in z-pinch plasmas. X-pinch plasmas driven by 0.2 MA currents were found to have source sizes of 1 micron, temperatures >1 keV, lifetimes of 10-100 ps, and densities >0.1 times solid density. These conditions are believed to result from the direct magnetic compression of matter. Physical models that capture the behavior of 0.2 MA X pinches predict more extreme parameters at currents >1 MA. This project developed load designs for up to 6 MA on the SATURN facility and attempted to measure the resulting plasma parameters. Source sizes of 5-8 microns were observed in some cases along with evidence for high temperatures (several keV) and short time durations (<500 ps).

  14. The Target of the Question: A Taxonomy of Textual Features for Cambridge University "O" Levels English

    ERIC Educational Resources Information Center

    Benjamin, Shanti Isabelle

    2015-01-01

    This study investigates the typical textual features that are most frequently targeted in short-answer reading comprehension questions of the Cambridge University "O" Level English Paper 2. Test writers' awareness of how textual features impact on understanding of meanings in text decisions will determine to great extent their decisions…

  15. Genetic Influences on Cognitive Function Using the Cambridge Neuropsychological Test Automated Battery

    ERIC Educational Resources Information Center

    Singer, Jamie J.; MacGregor, Alex J.; Cherkas, Lynn F.; Spector, Tim D.

    2006-01-01

    The genetic relationship between intelligence and components of cognition remains controversial. Conflicting results may be a function of the limited number of methods used in experimental evaluation. The current study is the first to use CANTAB (The Cambridge Neuropsychological Test Automated Battery). This is a battery of validated computerised…

  16. Curriculum, Pedagogy, and the Cambridge Primary Review: A Response to R. J. Campbell

    ERIC Educational Resources Information Center

    Armstrong, Michael

    2011-01-01

    This article presents the author's response to R.J. Campbell's critique of the "Cambridge Primary Review," which was published in the autumn of 2009. The author argues that Campbell's description of the "Review's" central proposals on curriculum and pedagogy as "backward-looking and inadequately theorised" is so misjudged as to call for a…

  17. Up the Garden Path: A Chemical Trail through the Cambridge University Botanic Garden

    ERIC Educational Resources Information Center

    Battle, Gary M.; Kyd, Gwenda O.; Groom, Colin R.; Allen, Frank H.; Day, Juliet; Upson, Timothy

    2012-01-01

    The living world is a rich source of chemicals with many medicines, dyes, flavorings, and foodstuffs having their origins in compounds produced by plants. We describe a chemical trail through the plant holdings of the Cambridge University Botanic Gardens. Visitors to the gardens are provided with a laminated trail guide with 22 stopping points…

  18. What To Look for in ESL Admission Tests: Cambridge Certificate Exams, IELTS, and TOEFL.

    ERIC Educational Resources Information Center

    Chalhoub-Deville, Micheline; Turner, Carolyn E.

    2000-01-01

    Familiarizes test users with issues to consider when employing assessments for screening and admission purposes. Examines the purpose, content, and scoring methods of three English-as-a-Second-Language admissions tests--the Cambridge certificate exams, International English Language Teaching System, and Test of English as a Foreign…

  19. Psychiatry in the Harvard Medical School-Cambridge Integrated Clerkship: An Innovative, Year-Long Program

    ERIC Educational Resources Information Center

    Griswold, Todd; Bullock, Christopher; Gaufberg, Elizabeth; Albanese, Mark; Bonilla, Pedro; Dvorak, Ramona; Epelbaum, Claudia; Givon, Lior; Kueppenbender, Karsten; Joseph, Robert; Boyd, J. Wesley; Shtasel, Derri

    2012-01-01

    Objective: The authors present what is to their knowledge the first description of a model for longitudinal third-year medical student psychiatry education. Method: A longitudinal, integrated psychiatric curriculum was developed, implemented, and sustained within the Harvard Medical School-Cambridge Integrated Clerkship. Curriculum elements…

  20. Linguistic Turn and Gendering Language in the Cambridge Advanced Learner's Dictionary

    ERIC Educational Resources Information Center

    Arimbi, Diah A.; Kwary, Deny A.

    2016-01-01

    Language constructs how humans perceive things. Since language is a human construction, it tends to be biased as it is mainly men's construction. Using gender perspectives, this paper attempts to discuss the imbalance in gender representations found in the examples given in an English learner's dictionary, that is, the "Cambridge Advanced…

  1. The Singapore-Cambridge General Certificate of Education Advanced-Level General Paper Examination

    ERIC Educational Resources Information Center

    Hassan, Nurul Huda; Shih, Chih-Min

    2013-01-01

    This article describes and reviews the Singapore-Cambridge General Certificate of Education Advanced Level General Paper (GP) examination. As a written test that is administered to preuniversity students, the GP examination is internationally recognised and accepted by universities and employers as proof of English competence. In this article, the…

  2. A Computerized Three-Dimensional Program Budget and Its Implementation at Cambridge School Department.

    ERIC Educational Resources Information Center

    Wong, S. Godwin

    This report describes the APL (Accountable unit, Program, and line item) budget system, a computerized three-dimensional program budget system that has been implemented in the Cambridge (Massachusetts) School Department. Various chapters discuss the differences between traditional budgeting and program budgeting, present an overview of te APL…

  3. The Cambridge Car Memory Test: a task matched in format to the Cambridge Face Memory Test, with norms, reliability, sex differences, dissociations from face memory, and expertise effects.

    PubMed

    Dennett, Hugh W; McKone, Elinor; Tavashmi, Raka; Hall, Ashleigh; Pidcock, Madeleine; Edwards, Mark; Duchaine, Bradley

    2012-06-01

    Many research questions require a within-class object recognition task matched for general cognitive requirements with a face recognition task. If the object task also has high internal reliability, it can improve accuracy and power in group analyses (e.g., mean inversion effects for faces vs. objects), individual-difference studies (e.g., correlations between certain perceptual abilities and face/object recognition), and case studies in neuropsychology (e.g., whether a prosopagnosic shows a face-specific or object-general deficit). Here, we present such a task. Our Cambridge Car Memory Test (CCMT) was matched in format to the established Cambridge Face Memory Test, requiring recognition of exemplars across view and lighting change. We tested 153 young adults (93 female). Results showed high reliability (Cronbach's alpha = .84) and a range of scores suitable both for normal-range individual-difference studies and, potentially, for diagnosis of impairment. The mean for males was much higher than the mean for females. We demonstrate independence between face memory and car memory (dissociation based on sex, plus a modest correlation between the two), including where participants have high relative expertise with cars. We also show that expertise with real car makes and models of the era used in the test significantly predicts CCMT performance. Surprisingly, however, regression analyses imply that there is an effect of sex per se on the CCMT that is not attributable to a stereotypical male advantage in car expertise.

  4. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare... 42 Public Health 5 2010-10-01 2010-10-01 false Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR...

  5. Ninth Cambridge Workshop on Cool Stars, Stellar Systems and the Sun

    NASA Technical Reports Server (NTRS)

    Dupree, Andrea K.

    1998-01-01

    This Grant was used to publish the Proceedings from the Ninth Cambridge Workshop on Cool Stars, Stellar Systems, and the Sun held in Florence, Italy from 3 to 6 October 1995. The Proceedings were published by the Astronomical Society of the Pacific in their Conference Series, Volume 109 in 1996. This volume was edited by Roberto Pallavicini and Andrea K. Dupree. A copy of the title page and the Table of Contents of the volume is appended.

  6. PET/MRI in the infarcted mouse heart with the Cambridge split magnet

    NASA Astrophysics Data System (ADS)

    Buonincontri, Guido; Sawiak, Stephen J.; Methner, Carmen; Krieg, Thomas; Hawkes, Robert C.; Adrian Carpenter, T.

    2013-02-01

    Chronic heart failure, as a result of acute myocardial infarction, is a leading cause of death worldwide. Combining diagnostic imaging modalities may aid the direct assessment of experimental treatments targeting heart failure in vivo. Here we present preliminary data using the Cambridge combined PET/MRI imaging system in a mouse model of acute myocardial infarction. The split-magnet design can deliver uncompromised MRI and PET performance, for better assessment of disease and treatment in a preclinical environment.

  7. Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline.

    PubMed

    Ding, Changhai; Jones, Graeme

    2006-05-01

    Belimumab, the lead in a series of human monoclonal antibodies against the human protein B-lymphocyte stimulator (BLyS), is under development by Human Genome Sciences, Cambridge Antibody Technology and GlaxoSmithKline for the potential treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year.

  8. Cambridge Homes Increases Energy Efficiency in a Mix of Housing Types

    SciTech Connect

    Poole, L.; Anderson, R.

    2001-06-12

    New houses designed by Cambridge Homes in Crest Hill, Illinois, with technical support from the U.S. Department of Energy's Building America Program, save their homeowners money by applying the principles of ''whole-building'' design to the entire home product line. Regardless of the model chosen, home buyers can enjoy consistently high levels of comfort and performance with the added benefit of reduced operating costs.

  9. Sir Joseph Barcroft, Cambridge placental and fetal research (1933-1966) and inter-generational Science.

    PubMed

    Boyd, Robert; Boyd, C A Richard

    2010-01-01

    The nature of Cambridge (UK) placental and fetal research in the middle third of the twentieth century is reviewed on the basis of published literature and personal recollection. Joseph Barcroft is a central figure who came to fetal research late in an extremely productive career which is briefly sketched. Contemporaneous Cambridge academics in the field included J.D. Boyd (the authors father), J. Hammond, F.H.A. Marshall, R.A. McCance, J. Needham, A.S. Parkes and Elsie Widdowson. The then current Cambridge academic geography is explained and features of its scientific life such as funding, institutional structure and ethos, teaching and clinical duties, domestic and gender roles, and political context, including war and empire, are briefly considered. The testing of research findings against general principles and use of quantitative thinking are identified as important features. Intergenerational connections, often within individual families, are identified as a striking feature. The long-term impact of Cambridge work of this period; locally, in current trophoblast and feto-placental genetic research, in Oxford in probably influencing G.S. Dawes research leadership, and internationally, especially through D.H. Barron, and through him to the Denver School, is considered. That human placental and embryological specimens collected by J.D. Boyd have received a new lease of life as the "Boyd Collection", including use by Allen Enders is noted. Mechanisms for the maintenance of scientific quality and productivity during the period, mainly through the scientist himself relying on an internalised sense of "obligation", are contrasted with those current in the UK and more widely; formal peer-review at frequent intervals, with subsequent allocation of short-term funding. The strengths and weaknesses of each are considered.

  10. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Hull, MA to Race Point, MA. 80.135 Section 80.135 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA....

  11. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS FOR...-EPs and MA-affiliated eligible hospitals. (a) General rule. A qualifying MA organization receives an incentive payment for its qualifying MA-EPs and its qualifying MA-eligible hospitals. The incentive...

  12. Electrophoresis technology experiment MA-011

    NASA Technical Reports Server (NTRS)

    Allen, R. E.; Barlow, G. H.; Bier, M.; Bigazzi, P. E.; Knox, R. J.; Micale, F. J.; Seaman, G. V. F.; Vanderhoff, J. W.; Vanoss, C. J.; Patterson, W. J.

    1976-01-01

    Experiment MA-011, electrophoresis technology, was designed to test electrophoresis hardware that would continue the development of technology for electrophoretic separation of materials in the near zero g environment of space. The experimental hardware generally functioned as planned. Frozen live cells were successfully transported into space, electrophoretic processing was performed, and viable cells were returned to earth. A separation of the three types of fixed red blood cells (rabbit, human, and horse) was demonstrated. The human lymphocytes, however, showed no apparent migration. The separation of human kidney cells produced the most exciting data. Analysis shows electrophoretic separation throughout the entire column with at least four bands of viable cells. The isotachophoresis experiment definitely demonstrated the isotachophoretic separation of biological cells in a near zero g environment.

  13. Inter-Noise 86 - Progress in noise control; Proceedings of the International Conference on Noise Control Engineering, Cambridge, MA, July 21-23, 1986. Volumes 1 & 2

    NASA Astrophysics Data System (ADS)

    Lotz, Robert

    The conference presents papers on legislative structure and engineering manpower in noise abatement legislation in Australia, fluid borne noise generation and transmission in hydraulic piping systems, and the application of the Fast Field Program to outdoor sound propagation. Other topics include a prediction model for airport ground noise propagation, diffraction by a barrier with finite acoustic impedance, sound propagation over curved barriers, the damping capacity of graphite epoxy composites in a vacuum, the realization of an airport noise monitoring system for determining the traffic flow in the surroundings of a military airbase, and the prediction of aircraft noise around airports by a simulation procedure. Papers are also presented on the effects of weather conditions on airport noise prediction, a prediction of the light aircraft interior sound pressure level from the measured sound pressure flowing into the cabin, and measurements with reference sources in the ISO 3740 series.

  14. International Conference on MHD Electrical Power Generation, 7th, Massachusetts Institute of Technology, Cambridge, MA, June 16-20, 1980, Proceedings. Volumes 1, 2 & 3

    NASA Astrophysics Data System (ADS)

    Dawson, A. M.; Overlan, D.

    The first volume of this conference on magnetohydrodynamics (MHD) for electrical power generation covers: (1) MHD pilot plants; (2) MHD generator experiments and modeling; (3) the performance of various MHD generator types; (4) MHD channel design considerations; (5) MHD channel materials considerations; (6) MHD system components, heat recovery and emissions; and (7) MHD oxidizers and inverters. The second volume deals with (8) MHD system magnets and combustors; (9) MHD field, flow and chemical processes; (10) MHD fluid dynamics; (11) MHD electrical power plant design; (12) current transfer and diagnostics; and (13) MHD power plant systems considerations.

  15. National Program for Inspection of Non-Federal Dams. Cambridge Reservoir Dam (MA 00750), Massachusetts Coastal Area, Waltham, Massachusetts. Phase I Inspection Report.

    DTIC Science & Technology

    1980-01-01

    on upstream slope, approximately 90 ft. right of intake struc- ture (pencil is 6 inches long).,. -.C - 4 JIM "l U " .... ... ,. 4 1 PHOTO NO. 5 - View...34 DATE ________"_- __ H it HAYDEN. HARDING t BUCHANAN. INC. Joe _ By_. _ _ _&B_ __CONSULTING ENGINEERS SUBJECT - ’ ’. Ŕ BY BOTON - w HS ARTFORD CLIENT

  16. IECON '87: Industrial applications of control and simulation; Proceedings of the 1987 International Conference on Industrial Electronics, Control, and Instrumentation, Cambridge, MA, Nov. 3, 4, 1987

    NASA Technical Reports Server (NTRS)

    Hartley, Tom T. (Editor)

    1987-01-01

    Recent advances in control-system design and simulation are discussed in reviews and reports. Among the topics considered are fast algorithms for generating near-optimal binary decision programs, trajectory control of robot manipulators with compensation of load effects via a six-axis force sensor, matrix integrators for real-time simulation, a high-level control language for an autonomous land vehicle, and a practical engineering design method for stable model-reference adaptive systems. Also addressed are the identification and control of flexible-limb robots with unknown loads, adaptive control and robust adaptive control for manipulators with feedforward compensation, adaptive pole-placement controllers with predictive action, variable-structure strategies for motion control, and digital signal-processor-based variable-structure controls.

  17. Sustainable Materials Management (SMM) Web Academy Webinar: Cupertino CA and Cambridge MA: Tips for How Communities Can Successfully Engage Businesses to Divert Food Scraps

    EPA Pesticide Factsheets

    This is a webinar page for the Sustainable Management of Materials (SMM) Web Academy webinar titled Let’s WRAP (Wrap Recycling Action Program): Best Practices to Boost Plastic Film Recycling in Your Community

  18. Neural Networks for Signal Processing 5. Proceedings of the 1995 IEEE Workshop (5th) Held in Cambridge, MA on 31 Aug-2 Sep 95.

    DTIC Science & Technology

    1995-01-01

    S.N. Siihari Decision conbihiaton1 inmlti pJ classiflor isystenms. IEEE Tea as. on2 Potts on Awlolys is anl /la chine 1%.t’r r . 6 7:4 5,1994. 6’ F...local Cerebral Glucose Utilization: The- ory, Procedures and Normal Values in the Conscious and Anesthetized Albino Rat" Journal of Neurochemistry 28 897

  19. Fundamentals of Tribology; Proceedings of the International Conference on the Fundamentals of Tribology held at The Massachusetts Institute of Technology, Cambridge, MA

    DTIC Science & Technology

    1978-06-01

    Massachusetts, 1975, p. 117. 14. Frost, H.J. and Ashby, M.F., "Deformation Mechanism Maps for Pure Iron, Two Austenitic Steels and a Low -Alloy Ferritic Steel ... steel .( 22) The coefficient of friction of Fe304 is initially low , but with sliding time it increases rapidly and then reaches a constant. It is...friction low -wear surface with intimate contact. The most common material for the continuous element is copper although stainless steel has been successfully

  20. Proceedings of the Aircraft Wake Vortices Conference, March 15-17, 1977, held at the Transportation Systems Center, Kendall Square, Cambridge, MA

    DTIC Science & Technology

    1977-06-01

    SERVICE. 5 N , 08VIR GINIA 22161 1 JUN 22 1978 ApproO-, io•AP.]iC r;. A•., i~~trib litio l ixa1117itod HELD AT THE TRANSPORTATION SYSTEMS CENTER . KENDALL...on aircraft wake vortices was sponsored by the Transportation Systems Center and supported by the Federal Aviation Adminis- tration, U.S. Deparment of...The Wake Vortex Hazard; James Andersen, Director, Office of Air and Marine Systems, Transportation Systems Center Session 11: Vortex Sensors and Data

  1. IECON '87: Signal acquisition and processing; Proceedings of the 1987 International Conference on Industrial Electronics, Control, and Instrumentation, Cambridge, MA, Nov. 3, 4, 1987

    NASA Astrophysics Data System (ADS)

    Niederjohn, Russell J.

    1987-01-01

    Theoretical and applications aspects of signal processing are examined in reviews and reports. Topics discussed include speech processing methods, algorithms, and architectures; signal-processing applications in motor and power control; digital signal processing; signal acquisition and analysis; and processing algorithms and applications. Consideration is given to digital coding of speech algorithms, an algorithm for continuous-time processes in discrete-time measurement, quantization noise and filtering schemes for digital control systems, distributed data acquisition for biomechanics research, a microcomputer-based differential distance and velocity measurement system, velocity observations from discrete position encoders, a real-time hardware image preprocessor, and recognition of partially occluded objects by a knowledge-based system.

  2. [The Cambridge Mental Disorders of the Elderly Examination. Study of interobserver reliability].

    PubMed

    Llinàs, J; Vilalta, J; López Pousa, S; Vidal, C; Amiel, J

    1990-04-01

    Three teams formed by psychologists with experience in the administration of structured interviews evaluated by the CAMDEX (The Cambridge Mental Disorders of the Elderly Examination) in a sample of 41 patients for the interrater reliability study. While a psychologist interview patient, the other one observes each patient. The CAMDEX were completed independently by each of the examiners. The results demonstrate an elevated level agreement both for the different scales (p less than 0.001) and for the different diagnostic criteria employed by the CAMDEX (kappa = 0.88 for the DSM-III-R and Kappa = 1 for the ICD-10).

  3. Building America Case Study: Boiler Control Replacement for Hydronically Heated Multifamily Buildings, Cambridge, Massachusetts (Fact Sheet)

    SciTech Connect

    Not Available

    2014-11-01

    The ARIES Collaborative, a U.S. Department of Energy Building America research team, partnered with NeighborWorks America affiliate Homeowners' Rehab Inc. (HRI) of Cambridge, Massachusetts, to study improvements to the central hydronic heating system in one of the nonprofit's housing developments. The heating controls in the three-building, 42-unit Columbia Cambridge Alliance for Spanish Tenants housing development were upgraded. Fuel use in the development was excessive compared to similar properties. A poorly insulated thermal envelope contributed to high energy bills, but adding wall insulation was not cost-effective or practical. The more cost-effective option was improving heating system efficiency. Efficient operation of the heating system faced several obstacles, including inflexible boiler controls and failed thermostatic radiator valves. Boiler controls were replaced with systems that offer temperature setbacks and one that controls heat based on apartment temperature in addition to outdoor temperature. Utility bill analysis shows that post-retrofit weather-normalized heating energy use was reduced by 10%-31% (average of 19%). Indoor temperature cutoff reduced boiler runtime (and therefore heating fuel consumption) by 28% in the one building in which it was implemented. Nearly all savings were obtained during night which had a lower indoor temperature cut off (68 degrees F) than day (73 degrees F). This implies that the outdoor reset curve was appropriately adjusted for this building for daytime operation. Nighttime setback of heating system supply water temperature had no discernable impact on boiler runtime or gas bills.

  4. Technology Solutions Case Study: Boiler Control Replacement for Hydronically Heated Multifamily Buildings, Cambridge, Massachusetts

    SciTech Connect

    2014-11-01

    The ARIES Collaborative, a U.S. Department of Energy Building America research team, partnered with NeighborWorks America affiliate Homeowners' Rehab Inc. (HRI) of Cambridge, Massachusetts, to study improvements to the central hydronic heating system in one of the nonprofit's housing developments. The heating controls in the three-building, 42-unit Columbia Cambridge Alliance for Spanish Tenants housing development were upgraded. Fuel use in the development was excessive compared to similar properties. A poorly insulated thermal envelope contributed to high energy bills, but adding wall insulation was not cost-effective or practical. The more cost-effective option was improving heating system efficiency, which faced several obstacles, including inflexible boiler controls and failed thermostatic radiator valves. Boiler controls were replaced with systems that offer temperature setbacks and one that controls heat based on apartment temperature in addition to outdoor temperature. Utility bill analysis shows that post-retrofit weather-normalized heating energy use was reduced by 10%-31% (average of 19%). Indoor temperature cutoff reduced boiler runtime (and therefore heating fuel consumption) by 28% in the one building in which it was implemented. Nearly all savings were obtained during night which had a lower indoor temperature cut off (68°F) than day (73° F). This implies that the outdoor reset curve was appropriately adjusted for this building for daytime operation. Nighttime setback of heating system supply water temperature had no discernable impact on boiler runtime or gas bills.

  5. The factors influencing car use in a cycle-friendly city: the case of Cambridge.

    PubMed

    Carse, Andrew; Goodman, Anna; Mackett, Roger L; Panter, Jenna; Ogilvie, David

    2013-04-01

    Encouraging people out of their cars and into other modes of transport, which has major advantages for health, the environment and urban development, has proved difficult. Greater understanding of the influences that lead people to use the car, particularly for shorter journeys, may help to achieve this. This paper examines the predictors of car use compared with the bicycle to explore how it may be possible to persuade more people to use the bicycle instead of the car. Multivariable logistic regression was used to examine the socio-demographic, transport and health-related correlates of mode choice for work, shopping and leisure trips in Cambridge, a city with high levels of cycling by UK standards. The key findings are that commuting distance and free workplace parking were strongly associated with use of the car for work trips, and car availability and lower levels of education were associated with car use for leisure, shopping and short-distanced commuting trips. The case of Cambridge shows that more policies could be adopted, particularly a reduction in free car parking, to increase cycling and reduce the use of the car, especially over short distances.

  6. Software Aspects of PuMa-II

    NASA Astrophysics Data System (ADS)

    Karuppusamy, R.; Stappers, B.; Stappers, B.

    2006-08-01

    The Pulsar Machine II (PuMa-II) is a state of the art pulsar machine-installed at the Westerbork Synthesis Radio Telescope (WSRT), in December 2005. PuMa-II is a flexible instrument and is designed around an ensemble of 44 high-performance computers running the Linux operating system. Much of the flexibility of PuMa-II comes from the software that is being developed for this instrument. The radio signals reaching the telescope undergo several stages of electronic and software processing before a scientifically useful data product is generated. The electronic processing of signals includes the usual RF to IF conversion, analogue to digital conversion and telescope dependent electronic digital delay compensation that happen in the signal chain of WSRT. Within PuMa-II, this data is acquired, stored and suitably processed. In this poster we present various aspects of PuMa-II software and illustrate its pulsar signal processing capabilities.

  7. 33 CFR 80.125 - Marblehead Neck, MA to Nahant, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marblehead Neck, MA to Nahant, MA. 80.125 Section 80.125 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.125 Marblehead Neck, MA to...

  8. 33 CFR 80.120 - Cape Ann, MA to Marblehead Neck, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Cape Ann, MA to Marblehead Neck, MA. 80.120 Section 80.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.120 Cape Ann, MA...

  9. Color discrimination across four life decades assessed by the Cambridge Colour Test.

    PubMed

    Paramei, Galina V

    2012-02-01

    Color discrimination was estimated using the Cambridge Colour Test (CCT) in 160 normal trichromats of four life decades, 20-59 years of age. For each age cohort, medians and tolerance limits of the CCT parameters are tabulated. Compared across the age cohorts (Kruskal-Wallis test), the Trivector test showed increases in the three vectors, Protan, Deutan, and Tritan, with advancing age; the Ellipses test revealed significant elongation of the major axes of all three ellipses but no changes in either the axis ratio or the angle of the ellipse major axis. Multiple comparisons (Mann-Whitney test) between the cohorts of four age decades (20+,…,50+) revealed initial benign deterioration of color discrimination in the 40+ decade, as an incremental loss of discrimination along the Deutan axis (Trivector test), and in the 50+ decade, as an elongation of the major axes of all three ellipses (Ellipses test).

  10. Floodplain management: Land acquisition versus preservation of historic buildings in Cambridge, Ontario, Canada

    NASA Astrophysics Data System (ADS)

    Bennett, Wendy J.; Mitchell, Bruce

    1983-07-01

    Non-structural adjustments in floodplain management are often avoided because they are seen to infringe on personal rights, adversely affect property values and restrict local tax bases. Land acquisition programs in urban areas encounter a further problem when they lead to demolition of buildings and other structures considered to have historical or architectural value. An experience in Cambridge, Ontario demonstrates that the potential conflict between flood damage reduction and historical preservation objectives can be exacerbated as a result of uncoordinated planning efforts, inflexibility in interpreting mandates, unclear roles for participating agencies, and lack of cooperation Many of these dilemmas can be resolved through consultation and discussion early in the planning process as well as through a willingness to be flexible and to search for a compromise

  11. Reginald Crundall Punnett: first Arthur Balfour Professor of Genetics, Cambridge, 1912.

    PubMed

    Edwards, A W F

    2012-09-01

    R. C. Punnett, the codiscoverer of linkage with W. Bateson in 1904, had the good fortune to be invited to be the first Arthur Balfour Professor of Genetics at Cambridge University, United Kingdom, in 1912 when Bateson, for whom it had been intended, declined to leave his new appointment as first Director of the John Innes Horticultural Institute. We here celebrate the centenary of the first professorship dedicated to genetics, outlining Punnett's career and his scientific contributions, with special reference to the discovery of "partial coupling" in the sweet pea (later "linkage") and to the diagram known as Punnett's square. His seeming reluctance as coauthor with Bateson to promote the reduplication hypothesis to explain the statistical evidence for linkage is stressed, as is his relationship with his successor as Arthur Balfour Professor, R. A. Fisher. The background to the establishment of the Professorship is also described.

  12. Experience from two decades of the Cambridge Rapid Access Neurology Clinic.

    PubMed

    Axinte, Laura T; Fiddes, Barnaby D; Donaghy, Alastair; Whyte, Adam; Allen, Chris; Sawcer, Stephen J; Adam, Robert J; Stacpoole, Sybil R L

    2015-10-01

    We report on the evolution of the rapid access neurology clinic (established in 1995) at Addenbrooke's Hospital, Cambridge. Annualised attendance data demonstrate an ever increasing demand, with primary headache disorders now accounting for more than 40% of referrals. Secondary causes of headache (including intracranial tumours, idiopathic intracranial hypertension, carotid or vertebral artery dissection and subdural haematomas) remain infrequent. In all such cases, there were additional diagnostic clues. The number of patients referred with problems related to chronic neurological diseases has fallen considerably, reflecting the roles of specialist nurses and clinics. Imaging investigation of choice shifted from computerised tomography scan (45 to 16%) towards magnetic resonance imaging (17 to 47%). Management is increasingly on an outpatient basis, often without the need for a follow-up appointment. The experience presented here should inform further development of rapid access neurology clinics across the UK and suggests the need for acute headache services, in line with those for transient ischaemic attack and first seizure.

  13. Reginald Crundall Punnett: First Arthur Balfour Professor of Genetics, Cambridge, 1912

    PubMed Central

    Edwards, A. W. F.

    2012-01-01

    R. C. Punnett, the codiscoverer of linkage with W. Bateson in 1904, had the good fortune to be invited to be the first Arthur Balfour Professor of Genetics at Cambridge University, United Kingdom, in 1912 when Bateson, for whom it had been intended, declined to leave his new appointment as first Director of the John Innes Horticultural Institute. We here celebrate the centenary of the first professorship dedicated to genetics, outlining Punnett’s career and his scientific contributions, with special reference to the discovery of “partial coupling” in the sweet pea (later “linkage”) and to the diagram known as Punnett’s square. His seeming reluctance as coauthor with Bateson to promote the reduplication hypothesis to explain the statistical evidence for linkage is stressed, as is his relationship with his successor as Arthur Balfour Professor, R. A. Fisher. The background to the establishment of the Professorship is also described. PMID:22964834

  14. Bericht uber den 2. Internationalen Kongress fur Angewandte Linguistik. Cambridge 8.-12. IX. 1969. [Report on the Second International Congress for Applied Linguistics, Cambridge, Dec. 8-12, 1969.

    ERIC Educational Resources Information Center

    Mohr, Peter

    This paper is a summary report on the Second International Congress of Applied Linguistics held in Cambridge, England in September 1969. Because of the large number of papers delivered, only a selection of the papers delivered in any one section of the Congress are considered, and the author attempts to identify current interests and trends in…

  15. The long-term impact of urbanisation on aquatic plants: Cambridge and the River Cam.

    PubMed

    Preston, C D; Sheail, J; Armitage, P; Davy-Bowker, J

    2003-10-01

    Historical and contemporary records have been used to assess the impact of urbanisation on the aquatic plants of the River Cam and its narrow floodplain in Cambridge. Of the 62 native aquatic plant species which have been recorded in the study area since 1660, 40 (65%) were still present in the period 1985-1999 whereas 22 (35%) are apparently extinct. There is a striking relationship between the fate of species and their trophic requirements, with species of less eutrophic habitats having suffered disproportionately. Historical records demonstrate that the River Cam became grossly polluted by sewage from Cambridge in the 19th century, but the chemical and biological quality of the river improved from 1897 onwards. However, the majority of the species recorded from the river and nearby ditches persisted until after maximum incidence of sewage pollution, which may even have stimulated the growth of 'weed' in the river. Losses of aquatic plant species from two riparian commons, Coe Fen (35%) and Sheep's Green (50%), have been particularly great. The level of these and other areas of low-lying common land by the river has been systematically raised by the controlled tipping of waste in hollows, followed by levelling and resowing. The main effects of urbanisation on the flora therefore arose from the transformation of riparian pastures into suburban open spaces. Commons which are used purely for amenity purposes have lost almost all their aquatic plant species. Those which are still grazed retain more, and continuance of grazing is probably essential if a varied aquatic flora is to be maintained. The interpretation of botanical records in terms of recorded management history is likely to throw further light on the processes of urbanisation, although the number of sites with a sufficiently detailed botanical record may be limited.

  16. Healthy Living Cambridge Kids: a community-based participatory effort to promote healthy weight and fitness.

    PubMed

    Chomitz, Virginia R; McGowan, Robert J; Wendel, Josefine M; Williams, Sandra A; Cabral, Howard J; King, Stacey E; Olcott, Dawn B; Cappello, Maryann; Breen, Susan; Hacker, Karen A

    2010-02-01

    The objective of this study was to assess the impact of a community-based healthy weight intervention on child weight and fitness. Cambridge Public Schools (CPS) have monitored BMI and fitness annually since 2000. Annual increases of overweight and obesity from 2000 (37.0%) to 2004 (39.1%), triggered a multidisciplinary team of researchers, educators, health care, and public health professionals to mobilize environmental and policy interventions. Guided by the social-ecological model and community-based participatory research (CBPR) principles, the team developed and implemented Healthy Living Cambridge Kids (HLCK), a multicomponent intervention targeting community, school, family, and individuals. The intervention included city policies and community awareness campaigns; physical education (PE) enhancements, food service reforms, farm-to-school-to-home programs; and family outreach and "BMI and fitness reports". Baseline (2004) to follow-up (2007) evaluation design assessed change in children's weight and fitness status. A cohort of 1,858 K-5th grade children participated: 37.3% black, 14.0% Hispanic, 37.1% white, 10.2% Asian, 1.7% other race; 43.3% were lower income. BMI z-score (0.67-0.63 P < 0.001) and proportion obese (20.2-18.0% P < 0.05) decreased, and mean number of fitness tests (0-5) passed increased (3.7-3.9 P < 0.001). Whereas black and Hispanic children were more likely to be obese at baseline (27.0 and 28.5%, respectively) compared with white (12.6%) and Asian (14.3%) children, obesity among all race/ethnicity groups declined. Concurrent with a 3-year community intervention, modest improvements in obesity and fitness were observed among CPS children from baseline to follow-up. The CBPR approach facilitated sustaining policies and program elements postintervention in this diverse community.

  17. A computer-controlled color vision test for children based on the Cambridge Colour Test.

    PubMed

    Goulart, Paulo R K; Bandeira, Marcio L; Tsubota, Daniela; Oiwa, Nestor N; Costa, Marcelo F; Ventura, Dora F

    2008-01-01

    The present study aimed at providing conditions for the assessment of color discrimination in children using a modified version of the Cambridge Colour Test (CCT, Cambridge Research Systems Ltd., Rochester, UK). Since the task of indicating the gap of the Landolt C used in that test proved counterintuitive and/or difficult for young children to understand, we changed the target stimulus to a patch of color approximately the size of the Landolt C gap (about 7 degrees of visual angle at 50 cm from the monitor). The modifications were performed for the CCT Trivector test which measures color discrimination for the protan, deutan and tritan confusion lines. Experiment 1 sought to evaluate the correspondence between the CCT and the child-friendly adaptation with adult subjects (n = 29) with normal color vision. Results showed good agreement between the two test versions. Experiment 2 tested the child-friendly software with children 2 to 7 years old (n = 25) using operant training techniques for establishing and maintaining the subjects' performance. Color discrimination thresholds were progressively lower as age increased within the age range tested (2 to 30 years old), and the data--including those obtained for children--fell within the range of thresholds previously obtained for adults with the CCT. The protan and deutan thresholds were consistently lower than tritan thresholds, a pattern repeatedly observed in adults tested with the CCT. The results demonstrate that the test is fit for assessment of color discrimination in young children and may be a useful tool for the establishment of color vision thresholds during development.

  18. PuMa, a digital Pulsar Machine

    NASA Astrophysics Data System (ADS)

    Voûte, J. L. L.; Kouwenhoven, M. L. A.; van Haren, P. C.; Langerak, J. J.; Stappers, B. W.; Driesens, D.; Ramachandran, R.; Beijaard, Th. D.

    2002-04-01

    We have designed and constructed PuMa, a pulsar machine that has both a baseband recording and a digital filterbank mode. Its design is based on the use of digital signal processors (DSPs). Their operation is controlled by software, which makes PuMa reconfigurable, flexible and easy to operate. The maximum number of channels in the digital filterbank mode is 32 768 over a bandwidth of 80 MHz. This makes PuMa suitable for pulsar observations at low sky frequencies. The maximum bandwidth in baseband recording mode is two times 10 MHz. The machine was installed at the Westerbork Synthesis Radio Telescope in The Netherlands in 1998. We discuss in some detail PuMa's technical properties and capabilities. Recent observations, a sample of which are presented here, demonstrate its capabilities and that it is performing up to its specifications.

  19. S&MA Requirements Tool (SMART)

    NASA Technical Reports Server (NTRS)

    Kulpa, Vyga

    2004-01-01

    In FY03 QS10 began building an S&MA web based data management tool,"Safety & Mission Assurance Requirements Tool" (SMART) that identifies S&MA requirements, tailors requirements to IAW project/program categories, tracks implementation, and provides a template for developing requirements and tracking waivers. This report provides a SMART process flow, typical application, typical data requirement deliverables, progress in 03, and FY04 activities.

  20. Assessing the Impact of the Cambridge International Acceleration Program on U.S. University Determinants of Success: A Multi-Level Modeling Approach

    ERIC Educational Resources Information Center

    Shaw, Stuart; Warren, Jayne; Gill, Tim

    2014-01-01

    This article focuses on the research being conducted by Cambridge International Examinations (Cambridge) to ensure that its international assessments prepare students as well as other acceleration programs for continued study in U.S. colleges and universities. The study, which builds on previous freshman GPA data modeling work using data supplied…

  1. The Potential Impact of High-Speed Networking on Teaching and Learning: A Case Study from Cambridge University.

    ERIC Educational Resources Information Center

    Aston, J.; Gienke, M.

    1995-01-01

    A report on the SuperJANET high-speed network included interviews conducted at Cambridge University (England) on the use of computers and audiovisual aids in university teaching and learning. Results indicated the emergence of two main uses of the technology: (1) as a means of communication between students and teachers, and (2) as a means of…

  2. M-DCPS Student Performance in International Baccalaureate and Cambridge Advanced International Certificate of Education Programs. Research Brief. Volume 1102

    ERIC Educational Resources Information Center

    Blazer, Christie

    2011-01-01

    This Research Brief summarizes the performance of M-DCPS students participating in the International Baccalaureate (IB) and Cambridge Advanced International Certificate of Education (AICE) programs. Outcome data are provided for the eight M-DCPS schools offering the two programs and corresponding examinations. Participation in international…

  3. State Control, Religious Deference and Cultural Reproduction: Some Problems with Theorising Curriculum and Pedagogy in the Cambridge Primary Review

    ERIC Educational Resources Information Center

    Campbell, R. J.

    2011-01-01

    This article offers a critique of the quality of theorising underlying proposals on curriculum and pedagogy in the Cambridge Primary Review. Despite its strengths, the review is seen as omitting consideration of three major areas in primary education: gifted pupils, teacher effectiveness research and the private sector. Questions are raised about…

  4. Source-Water Protection and Water-Quality Investigations in the Cambridge, Massachusetts, Drinking-Water Supply System

    USGS Publications Warehouse

    Waldron, Marcus C.; Norton, Chip; MacDonald, Timothy W.D.

    1998-01-01

    Introduction The Cambridge Water Department (CWD) supplies about 15 million gallons of water each day to more than 95,000 customers in the City of Cambridge, Massachusetts. Most of this water is obtained from a system of reservoirs located in Cambridge and in parts of five other suburban-Boston communities. The drainage basin that contributes water to these reservoirs includes several potential sources of drinking-water contaminants, including major highways, secondary roads, areas of commercial and industrial development, and suburban residential tracts. The CWD is implementing a comprehensive Source-Water Protection Plan to ensure that the highest quality water is delivered to the treatment plant. A key element of this plan is a program that combines systematic monitoring of the drainage basin with detailed investigations of the effects of nonpoint-source contaminants, such as highway-deicing chemicals, nutrients, oxygen-demanding organic compounds, bacteria, and trace metals arising from stormwater runoff. The U.S. Geological Survey (USGS) is working with the CWD and the Massachusetts Highway Department (MassHighway) to develop a better understanding of the sources, transport, and fate of many of these contaminants. This Fact Sheet describes source-water protection and water-quality investigations currently underway in the Cambridge drinking-water supply system. The investigations are designed to complement a national effort by the USGS to provide water suppliers and regulatory agencies with information on the vulnerability of water supplies and the movement and fate of source-water contaminants.

  5. Preparing for College Success: Exploring the Impact of the High School Cambridge Acceleration Program on U.S. University Students

    ERIC Educational Resources Information Center

    Shaw, Stuart D.; Werno, Magda A.

    2016-01-01

    This case study sought to gain a better understanding of the impact of the Cambridge Acceleration Program on students' transition from high school to college at one American university. The findings from an online questionnaire indicate that many participants develop a range of skills that are perceived as important in the context of university…

  6. Towards the 1980s: Papers Presented at the BACIE Annual Conference at Trinity College, Cambridge, September 1968.

    ERIC Educational Resources Information Center

    British Association for Commercial and Industrial Education, London (England).

    The annual conference of the British Association for Commercial and Industrial Education (BACIE), held at Trinity College, Cambridge, England, in September 1968, was devoted to educational objectives for England for the 1980's. The three speeches presented were, "The Objectives of Society" (Sir Herbert Butterfield), "Industry in the…

  7. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128

    PubMed Central

    Kim, Dong-Seon; Kim, Seung-Hyung; Kim, Bok-Kyu; Yang, Min Cheol; Ma, Jin Yeul

    2012-01-01

    This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma. Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges. MA and MA128 were orally administered 6 times a week for 4 weeks. At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis. We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma. In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-γ), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells. The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus. PMID:22203879

  8. MaRIE Undulator & XFEL Systems

    SciTech Connect

    Nguyen, Dinh Cong; Marksteiner, Quinn R.; Anisimov, Petr Mikhaylovich; Buechler, Cynthia Eileen

    2015-03-23

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  9. Spectrofluorometric method for measuring tobacco smoke particulate matter on cigarette filters and Cambridge pads.

    PubMed

    Paszkiewicz, G M; Pauly, J L

    2008-09-01

    Almost all cigarettes sold have a filter (United States, >98%; worldwide, >95%). In the last 25 years cigarette manufacturers have introduced diverse filters designed to reduce components in tobacco smoke. Today, there exists a need to establish assays to assess the efficacy of cigarette filters to retain total particulate matter (TPM), particularly unique filters of cigarettes that are being marketed as potential reduced exposure products (PREPs). We report the results of studies that were undertaken to test the hypothesis that a technique could be established for dissolving cigarette filters, and that the TPM in the fluid could be quantified by spectrofluorometry. Described here are procedures for assaying TPM on both Cambridge filter pads (glass fibres) of smoking machines and on cigarette filters (cellulose acetate fibres). The principle of the assays is based upon the observation that there exists a direct correlation between the amount of tobacco product emission TPM and fluorescence. In the absence of a tobacco tar or TPM standard, the fluorescent dye acridine orange was confirmed as a useful surrogate. Filters assayed included those of Kentucky reference cigarettes 2R4F and popular US brand cigarettes. The proposed assays are inexpensive, expedient, reproducible and amendable for large-scale studies.

  10. Item response theory analyses of the Cambridge Face Memory Test (CFMT).

    PubMed

    Cho, Sun-Joo; Wilmer, Jeremy; Herzmann, Grit; McGugin, Rankin Williams; Fiset, Daniel; Van Gulick, Ana E; Ryan, Kaitlin F; Gauthier, Isabel

    2015-06-01

    We evaluated the psychometric properties of the Cambridge Face Memory Test (CFMT; Duchaine & Nakayama, 2006). First, we assessed the dimensionality of the test with a bifactor exploratory factor analysis (EFA). This EFA analysis revealed a general factor and 3 specific factors clustered by targets of CFMT. However, the 3 specific factors appeared to be minor factors that can be ignored. Second, we fit a unidimensional item response model. This item response model showed that the CFMT items could discriminate individuals at different ability levels and covered a wide range of the ability continuum. We found the CFMT to be particularly precise for a wide range of ability levels. Third, we implemented item response theory (IRT) differential item functioning (DIF) analyses for each gender group and 2 age groups (age ≤ 20 vs. age > 21). This DIF analysis suggested little evidence of consequential differential functioning on the CFMT for these groups, supporting the use of the test to compare older to younger, or male to female, individuals. Fourth, we tested for a gender difference on the latent facial recognition ability with an explanatory item response model. We found a significant but small gender difference on the latent ability for face recognition, which was higher for women than men by 0.184, at age mean 23.2, controlling for linear and quadratic age effects. Finally, we discuss the practical considerations of the use of total scores versus IRT scale scores in applications of the CFMT.

  11. Swift observations of unidentified radio sources in the revised Third Cambridge Catalogue

    NASA Astrophysics Data System (ADS)

    Maselli, A.; Massaro, F.; Cusumano, G.; La Parola, V.; Harris, D. E.; Paggi, A.; Liuzzo, E.; Tremblay, G. R.; Baum, S. A.; O'Dea, C. P.

    2016-08-01

    We have investigated a group of unassociated radio sources included in the Third Cambridge Catalogue (3CR) to increase the multifrequency information on them and possibly obtain an identification. We have carried out an observational campaign with the Swift satellite to observe with the Ultraviolet/Optical Telescope (UVOT) and the X-Ray Telescope (XRT) the field of view of 21 bright NRAO VLA Sky Survey (NVSS) sources within the positional uncertainty region of the 3CR sources. Furthermore, we have searched in the recent AllWISE Source Catalogue for infrared sources matching the position of these NVSS sources. We have detected significant emission in the soft X-ray band for nine of the investigated NVSS sources. To all of them, and in four cases with no soft X-ray association, we have associated a Wide-field Infrared Survey Explorer infrared counterpart. Eight of these infrared candidates have not been proposed earlier in the literature. In the five remaining cases our candidate matches one among a few optical candidates suggested for the same 3CR source in previous studies. No source has been detected in the UVOT filters at the position of the NVSS objects, confirming the scenario that all of them are heavily obscured. With this in mind, a spectroscopic campaign, preferably in the infrared band, will be necessary to establish the nature of the sources that we have finally identified.

  12. Face recognition performance of individuals with Asperger syndrome on the Cambridge Face Memory Test.

    PubMed

    Hedley, Darren; Brewer, Neil; Young, Robyn

    2011-12-01

    Although face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ-matched non-ASD individuals, and age-standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non-ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/- 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non-ASD levels of performance.

  13. Ma'adim Vallis From the Top

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is a still from an animation showing the geography of Ma'adim Vallis, a valley or channel that enters Gusev Crater. The view of the crater is from the northwest, which is not the direction from which Spirit approached the crater as it landed.

  14. Vaccines against stimulants: cocaine and MA.

    PubMed

    Kosten, Thomas; Domingo, Coreen; Orson, Frank; Kinsey, Berma

    2014-02-01

    While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited success. Anti-addiction vaccines, on the other hand, have demonstrated great potential for treating drug abuse using a distinctly different mechanism of eliciting an antibody response that blocks the pharmacological effects of drugs. We provide a review of vaccine-based approaches to treating stimulant addictions; specifically and cocaine addictions. This selective review article focuses on the one cocaine vaccine that has been into clinical trials and presents new data related to pre-clinical development of a methamphetamine (MA) vaccine. We also review the mechanism of action for vaccine induced antibodies to abused drugs, which involves kinetic slowing of brain entry as well as simple blocking properties. We present pre-clinical innovations for MA vaccines including hapten design, linkage to carrier proteins and new adjuvants beyond alum. We provide some new information on hapten structures and linkers and variations in protein carriers. We consider a carrier, outer membrance polysaccharide coat protein (OMPC), that provides some self-adjuvant through lipopolysaccharide components and provide new results with a monophosopholipid adjuvant for the more standard carrier proteins with cocaine and MA. The review then covers the clinical trials with the cocaine vaccine TA-CD. The clinical prospects for advances in this field over the next few years include a multi-site cocaine vaccine clinical trial to be reported in 2013 and phase 1 clinical trials of a MA vaccine in 2014.

  15. Fabrication technology for ODS Alloy MA957

    SciTech Connect

    ML Hamilton; DS Gelles; RJ Lobsinger; MM Paxton; WF Brown

    2000-03-16

    A successful fabrication schedule has been developed at Carpenter Technology Corporation for the production of MA957 fuel and blanket cladding. Difficulties with gun drilling, plug drawing and recrystallization were overcome to produce a pilot lot of tubing. This report documents the fabrication efforts of two qualified vendors and the support studies performed at WHC to develop the fabrication-schedule.

  16. 76 FR 40766 - Massachusetts Disaster #MA-00035

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ADMINISTRATION Massachusetts Disaster MA-00035 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 06/29/2011. Incident: Johnsonia Apartment Building Fire Incident Period:...

  17. 76 FR 30748 - Massachusetts Disaster #MA-00033

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... ADMINISTRATION Massachusetts Disaster MA-00033 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/19/2011. Incident: Apartment Building Fire. Incident Period: 04/30/2011. Effective...

  18. 77 FR 12350 - Massachusetts Disaster #MA-00047

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... ADMINISTRATION Massachusetts Disaster MA-00047 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 02/21/2012. Incident: Brookline Apartment Building Fire. Incident Period:...

  19. 75 FR 79064 - Massachusetts Disaster #MA-00030

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... ADMINISTRATION Massachusetts Disaster MA-00030 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 12/07/2010. Incident: Apartment complex fire. Incident Period: 11/21/2010. Effective...

  20. 75 FR 3764 - Massachusetts Disaster # MA-00024

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... ADMINISTRATION Massachusetts Disaster MA-00024 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 01/15/2010. Incident: Mystic Side Estates Apartment Building Fire. Incident Period:...

  1. 77 FR 33263 - Massachusetts Disaster #MA-00048

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... ADMINISTRATION Massachusetts Disaster MA-00048 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated 05/29/2012. Incident: Lake Williams Condominium Complex Fire. Incident Period:...

  2. 77 FR 76584 - Massachusetts Disaster # MA-00051

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ...] [FR Doc No: 2012-31302] SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13420 and 13421] Massachusetts Disaster MA-00051 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Massachusetts dated...

  3. 78 FR 25336 - Massachusetts Disaster #MA-00054

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Massachusetts Disaster MA-00054 AGENCY: U.S. Small Business Administration. ACTION: Notice...: 01/21/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business...

  4. Multi-MA reflex triode research.

    SciTech Connect

    Swanekamp, Stephen Brian; Commisso, Robert J.; Weber, Bruce V.; Riordan, John C.; Allen, Raymond J.; Goyer, John R.; Murphy, Donald P.; Mikkelson, Kenneth A.; Harper-Slaboszewicz, Victor Jozef

    2010-08-01

    The Reflex Triode can efficiently produce and transmit medium energy (10-100 keV) x-rays. Perfect reflexing through thin converter can increase transmission of 10-100 keV x-rays. Gamble II experiment at 1 MV, 1 MA, 60 ns - maximum dose with 25 micron tantalum. Electron orbits depend on the foil thickness. Electron orbits from LSP used to calculate path length inside tantalum. A simple formula predicts the optimum foil thickness for reflexing converters. The I(V) characteristics of the diode can be understood using simple models. Critical current dominates high voltage triodes, bipolar current is more important at low voltage. Higher current (2.5 MA), lower voltage (250 kV) triodes are being tested on Saturn at Sandia. Small, precise, anode-cathode gaps enable low impedance operation. Sample Saturn results at 2.5 MA, 250 kV. Saturn dose rate could be about two times greater. Cylindrical triode may improve x-ray transmission. Cylindrical triode design will be tested at 1/2 scale on Gamble II. For higher current on Saturn, could use two cylindrical triodes in parallel. 3 triodes in parallel require positive polarity operation. 'Triodes in series' would improve matching low impedance triodes to generator. Conclusions of this presentation are: (1) Physics of reflex triodes from Gamble II experiments (1 MA, 1 MV) - (a) Converter thickness 1/20 of CSDA range optimizes x-ray dose; (b) Simple model based on electron orbits predicts optimum thickness from LSP/ITS calculations and experiment; (c) I(V) analysis: beam dynamics different between 1 MV and 250 kV; (2) Multi-MA triode experiments on Saturn (2.5 MA, 250 kV) - (a) Polarity inversion in vacuum, (b) No-convolute configuration, accurate gap settings, (c) About half of current produces useful x-rays, (d) Cylindrical triode one option to increase x-ray transmission; and (3) Potential to increase Saturn current toward 10 MA, maintaining voltage and outer diameter - (a) 2 (or 3) cylindrical triodes in parallel, (b) Triodes

  5. The Cambridge Face Tracker: Accurate, Low Cost Measurement of Head Posture Using Computer Vision and Face Recognition Software

    PubMed Central

    Thomas, Peter B. M.; Baltrušaitis, Tadas; Robinson, Peter; Vivian, Anthony J.

    2016-01-01

    Purpose We validate a video-based method of head posture measurement. Methods The Cambridge Face Tracker uses neural networks (constrained local neural fields) to recognize facial features in video. The relative position of these facial features is used to calculate head posture. First, we assess the accuracy of this approach against videos in three research databases where each frame is tagged with a precisely measured head posture. Second, we compare our method to a commercially available mechanical device, the Cervical Range of Motion device: four subjects each adopted 43 distinct head postures that were measured using both methods. Results The Cambridge Face Tracker achieved confident facial recognition in 92% of the approximately 38,000 frames of video from the three databases. The respective mean error in absolute head posture was 3.34°, 3.86°, and 2.81°, with a median error of 1.97°, 2.16°, and 1.96°. The accuracy decreased with more extreme head posture. Comparing The Cambridge Face Tracker to the Cervical Range of Motion Device gave correlation coefficients of 0.99 (P < 0.0001), 0.96 (P < 0.0001), and 0.99 (P < 0.0001) for yaw, pitch, and roll, respectively. Conclusions The Cambridge Face Tracker performs well under real-world conditions and within the range of normally-encountered head posture. It allows useful quantification of head posture in real time or from precaptured video. Its performance is similar to that of a clinically validated mechanical device. It has significant advantages over other approaches in that subjects do not need to wear any apparatus, and it requires only low cost, easy-to-setup consumer electronics. Translational Relevance Noncontact assessment of head posture allows more complete clinical assessment of patients, and could benefit surgical planning in future. PMID:27730008

  6. 42 CFR 495.204 - Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CERTIFICATION STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to... 42 Public Health 5 2010-10-01 2010-10-01 false Incentive payments to qualifying MA organizations for MA-EPs and MA-affiliated eligible hospitals. 495.204 Section 495.204 Public Health CENTERS...

  7. The German adaptation of the Cambridge pulmonary hypertension outcome review (CAMPHOR)

    PubMed Central

    2012-01-01

    Background Individuals with precapillary pulmonary hypertension (PH) experience severely impaired quality of life. A disease-specific outcome measure for PH, the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) was developed and validated in the UK and subsequently adapted for use in additional countries. The aim of this study was to translate and assess the reliability and validity of the CAMPHOR for German-speaking populations. Methods Three main adaptation stages involved; translation (employing bilingual and lay panels), cognitive debriefing interviews with patients and validation (assessment of the adaptation’s psychometric properties). The psychometric evaluation included 107 patients with precapillary PH (60 females; age mean (standard deviation) 60 (15) years) from 3 centres in Austria, Germany and Switzerland. Results No major problems were found with the translation process with most items easily rendered into acceptable German. Participants in the cognitive debriefing interviews found the questionnaires relevant, comprehensive and easy to complete. Psychometric analyses showed that the adaptation was successful. The three CAMPHOR scales (symptoms, activity limitations and quality of life) had excellent test-retest reliability correlations (Symptoms = 0.91; Activity limitations = 0.91; QoL = 0.90) and internal consistency (Symptoms = 0.94; Activity limitations = 0.93; QoL = 0.94). Predicted correlations with the Nottingham Health Profile provided evidence of the construct validity of the CAMPHOR scales. The CAMPHOR adaptation also showed known group validity in its ability to distinguish between participants based on perceived general health, perceived disease severity, oxygen use and NYHA classification. Conclusions The CAMPHOR has been shown to be valid and reliable in the German population and is recommend for use in clinical practice. PMID:22971041

  8. RELIABILITY, VALIDITY, AND PSYCHOMETRIC PROPERTIES OF THE GREEK TRANSLATION OF THE CAMBRIDGE DEPERSONALIZATION SCALE (CDS)

    PubMed Central

    Kontoangelos, Konstantinos; Tsiori, Sofia; Poulakou, Garyfalia; Protopapas, Konstantinos; Katsarolis, Ioannis; Sakka, Vissaria; Kavatha, Dimitra; Papadopoulos, Antonios; Antoniadou, Anastasia; Papageorgiou, Charalambos C.

    2016-01-01

    Introduction: The Cambridge Depersonalisation Scale is meant to capture the frequency and duration of depersonalisation symptoms over the ‘last 6 months’. Methods: In order to develop a Greek version of CDS scale, the CDS scale was translated in Greek by 2 psychiatrists. Then, the Greek version of CDS scale was back-translated by a person who did not knew the original English version. The back-translated version was reviewed in order to establish whether is consistent with the original English version. After this procedure we administered the Greek version of CDS scale to a sample of 294 Greeks in order to assess the reliability and the validity of the Greek version of scale. Results: The five components solution accounted for 58.204% of the total variation. Initial eigenvalues of the five components were: factor 1=11.555, factor 2=1.564, factor 3=1.356, factor 4=1.247 and factor 5=1.157. Six items did not load on any factor. Correlations between factors were low ranged from 0.134 to 0.314 and no complex variables were found. Cronbach’s alpha and Guttman split-half coefficient were used to evaluate interval consistency of CDS scale in 294 individuals. The alpha coefficients and Guttman split-half coefficient of the CDS scale were 0.938 and 0.921, respectively. The test-retest reliability proved to be satisfactory. The intraclass correlation coefficients for the total CDS score was very good and equal to 0,883. The CDS scale correlated highly with the SCL-90 and all subscales (p-value<0.0001). Conclusion: The psychometric strength of CDS – Greek its reliable for its future use, particularly for screening for subjects with possible diagnosis of CDS. PMID:27999491

  9. Mass and Reliability System (MaRS)

    NASA Technical Reports Server (NTRS)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  10. High-energy pair production of muons in electron-positron annihilation at center of mass energies ranging from 130 to 183 GeV

    NASA Astrophysics Data System (ADS)

    Smith, Bryan R.

    For the process e+e/sp-/rightarrow μ+/mu/sp- (nγ), the cross section and forward-backward charge asymmetry are measured at the highest ever center of mass energies which ranged from 130 to 183GeV. The data originates from 85pb-1 of integrated luminosity collected with the L3 detector at LEP. The measured muon pair cross section and forward-backward asymmetry agree with the Standard Model prediction with a χ SM2/N =.61 with 10 degrees of freedom. A mass limit on an additional heavy, neutral gauge boson of M Z' > 315GeV is set using muon pair production alone, rising to M Z' > 805GeV when all final states are considered. A search for an excited lepton decaying via /mu*/rightarrow/mu/gamma excludes such objects with electromagnetic coupling up to 183GeV. (Copies available exclusively from MIT Libraries, RM. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  11. Social Behaviour of Captive Belugas, Delphinapterus Leucas.

    NASA Astrophysics Data System (ADS)

    Recchia, Cheri Anne

    1994-01-01

    Focal-animal sampling techniques developed for investigating social behaviour of terrestrial animals were adapted for studying captive belugas, providing quantitative descriptions of social relationships among individuals. Five groups of captive belugas were observed, allowing a cross -sectional view of sociality in groups of diverse sizes and compositions. Inter-individual distances were used to quantify patterns of spatial association. A set of social behaviours for which actor and recipient could be identified was defined to characterize dyadic interactions. The mother-calf pair spent more time together, and interacted more often than adults. The calf maintained proximity with his mother; larger adults generally maintained proximity with smaller adults. Among adults, larger groups performed more kinds of behaviours and interacted at higher rates than smaller groups. Within dyads, the larger whale performed more aggressive behaviours and the smaller whale more submissive behaviours. Clear dominance relations existed in three groups, with larger whales dominant to smaller whales. Vocalizations of three groups were classified subjectively, based on aural impressions and visual inspection of spectrograms, but most signals appeared graded. Statistical analyses of measured acoustic features confirmed subjective impressions that vocalizations could not be classified into discrete and homogeneous categories. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-553-5668; Fax 617-253-1690.).

  12. Global modelling of non-axisymmetric disruptions and halo currents in tokamaks

    NASA Astrophysics Data System (ADS)

    McCarrick, James F.

    1997-12-01

    As tokamak plasmas become more robust with the development of increasingly advanced operating regimes, the occurrence of plasma disruptions places a greater demand on the tokamak structure. In particular, the flow of halo currents, large currents which appear in tokamak vacuum vessels as a result of direct contact with bulk plasma, has become a matter of increasing concern. Experimental measurements have confirmed the existence of large, toroidally asymmetric currents which flow poloidally in the wall, exerting strong localized forces on the wall as they interact with the toroidal magnetic field. A new model has been developed to study this phenomenon, based on the use of nested sheet currents to represent a disrupting plasma. This model contains the minimum number of degrees of freedom which permit the flow of continuous, non-axisymmetric poloidal and toroidal currents; furthermore, the model can be put into a compact integral formulation which allows rapid numerical solution even in the presence of complicated tokamak geometries. A fast code called TSPS-3D has been written to solve the sheet current model; the code has been matched against experimental data and used to examine basic scaling relationships of halo currents and the resulting J x B loads with plasma parameters. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

  13. Measurement of the neutral B meson decay mixing frequency using a new probability based self-tagging algorithm applied to inclusive lepton events from proton-antiproton collisions at center-of-mass energy = 1.8 TeV

    NASA Astrophysics Data System (ADS)

    Shah, Tushar

    We present a measurement of the Bd mixing frequency performed in an inclusive lepton sample, B --> l + X. A secondary vertex identifies a B meson decay, and a high pt lepton determines the flavor at the time of decay. We use a self-tagging algorithm (exploiting the correlation between the charge of particles produced along with a B meson and its flavor) in order to determine the B flavor at the time of production. Confusion of B daughter particles with charge-flavor correlated particles can cause significant degradation of the flavor tagging performance. Monte Carlo based probability distributions over kinematic and geometric properties of tracks are used to distinguish between potential self-tagging candidates and unidentified B meson daughters. We measure Δmd = 0.42 +/- 0.09(stat) +/- 0.03(sys) × (ps) -1. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  14. Interactions of light with matter: Applications to single molecule spectroscopy and quantum control

    NASA Astrophysics Data System (ADS)

    Brown, Frank Leon Halet

    Two different applications of the interaction between light and matter are discussed. First, we consider the single molecule spectra (SMS) of chromophores embedded in low temperature glasses. We demonstrate that it is possible to rationalize recent experimental results within the framework of the standard tunneling model (STM) for glassy dynamics as proposed by Anderson, Halperin and Varma and Phillips. Our analysis enables insight to be gained as to what features of the model are most important in describing experiment. Implicit in our treatment is the assumption that the two level systems, central to the STM, do not interact. The validity of this assumption is critically examined by extending the model to allow for such interactions. This complication of the theoretical model, beyond the lowest order implications of the STM, is found to influence individual spectra, but not the averaged quantities which are typically reported in the experimental literature. Our second application is a brief foray into the field of quantum control. Within the limit of weak applied fields and quadratic potentials for the control target, we describe a general method capable of determining the best possible field for affecting a desired configuration of the nuclear positions in the target. Several simple models are discussed within this framework to prove the validity of the formulation and its ease of implementation. Possibilities for extension to more complicated applications will be discussed. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307, Ph. 617-253-5668; Fax 617-253- 1690.)

  15. Earth-Moon Impacts at 300 Ma and 500 Ma Ago

    NASA Technical Reports Server (NTRS)

    Zellner, N. E. B.; Delano, J. W.; Swindle, T. D.; Barra, F.; Whittet, D. C. B.; Spudis, P. D.

    2005-01-01

    Impact events have played an important role in the evolution of planets and small bodies in the Solar System. Meteorites, lunar melt rocks, and lunar impact glasses provide important information about the geology of the parent body and the age of the impacting episodes. Over 2400 impact glasses from 4 Apollo regolith samples have been geochemically analyzed and a subset has been dated by the (40)Ar/(39)Ar method. New results, consistent with 2 break-ups in the Asteroid Belt, are presented here. Our previous study reported that (40)Ar/(39)Ar ages from 9 impact glasses showed that the Moon experienced significant impacts at approx. 800 Ma and at approx. 3800 Ma ago, somewhere in the vicinity of the Apollo 16 landing site. Additionally, reported on Apollo 12 samples with ages around 800 Ma, together implying global bombardment events. New data on 7 glasses from regolith sample 66041,127 show that the Moon also experienced impact events at approx. 300 Ma and > 500 Ma ago, which may coincide with the break-ups in the Asteroid Belt of the L- and H-chrondrite parent bodies. Since meteoritic evidence for these breakups has been found on Earth, it follows that evidence should be found in lunar samples as well. Additional information is included in the original extended abstract.

  16. Hydrologic, Water-Quality, and Meteorological Data for the Cambridge, Massachusetts, Drinking-Water Source Area, Water Year 2006

    USGS Publications Warehouse

    Smith, Kirk P.

    2008-01-01

    Records of water quantity, water quality, and meteorological parameters were continuously collected from three reservoirs, two primary streams, and four subbasin tributaries in the Cambridge, Massachusetts, drinking-water source area during water year 2006 (October 2005 through September 2006). Water samples were collected during base-flow conditions and storms in the subbasins of the Cambridge Reservoir and Stony Brook Reservoir drainage areas and analyzed for dissolved calcium, sodium, chloride, and sulfate; total nitrogen and phosphorus; and polar pesticides and metabolites. These data were collected to assist watershed administrators in managing the drinking-water source area and to identify potential sources of contaminants and trends in contaminant loading to the water supply. Monthly reservoir contents for the Cambridge Reservoir varied from about 59 to 98 percent of capacity during water year 2006, while monthly reservoir contents for the Stony Brook Reservoir and the Fresh Pond Reservoir was maintained at greater than 83 and 94 percent of capacity, respectively. If water demand is assumed to be 15 million gallons per day by the city of Cambridge, the volume of water released from the Stony Brook Reservoir to the Charles River during the 2006 water year is equivalent to an annual water surplus of about 127 percent. Recorded precipitation in the source area was about 16 percent greater for the 2006 water year than for the previous water year and was between 12 and 73 percent greater than for any recorded amount since water year 2002. The monthly mean specific-conductance values for all continuously monitored stations within the drinking-water source area were generally within the range of historical data collected since water year 1997, and in many cases were less than the historical medians. The annual mean specific conductance of 738 uS/cm (microsiemens per centimeter) for water discharged from the Cambridge Reservoir was nearly identical to the annual

  17. 1900-Ma ocean crust in Canada

    NASA Astrophysics Data System (ADS)

    Maggs, William Ward

    The oldest known occurrence in North America of an ophiolite, considered to be a piece of ancient ocean crust, has been reported in the Cape Smith Belt in northern Quebec, Canada.The recognition last summer of a key structural component of the characteristic ophiolite suite has buttressed confidence in the theory that the 1900-Ma fragments of an ocean basin were accreted to an early Proterozoic Canadian continent. The tectonic mixing of oceanic and continental crust is strong evidence for the operation of plate tectonics early in Earth's history.

  18. The history of early low frequency radio astronomy in Australia. 3: Ellis, Reber and the Cambridge field station near Hobart

    NASA Astrophysics Data System (ADS)

    George, Martin; Orchiston, Wayne; Slee, Bruce; Wielebinski, Richard

    2015-07-01

    Low frequency radio astronomy in Tasmania began with the arrival of Grote Reber to the State in 1954. After analysing ionospheric data from around the world, he concluded that Tasmania would be a very suitable place to carry out low frequency observations. Communications with Graeme Ellis in Tasmania, who had spent several years studying the ionosphere, led to a collaboration between the two in 1955 during which year they made observations at Cambridge, near Hobart. Their observations took place at four frequencies between 2.13 MHz and 0.52 MHz inclusive, with the results at the higher frequencies revealing a clear celestial component

  19. Roadmap to MaRIE March 2015

    SciTech Connect

    Barnes, Cris William

    2015-03-30

    Los Alamos National Laboratory’s proposed MaRIE facility is slated to introduce the world’s highest energy hard x-ray free electron laser (XFEL). As the light source for the Matter-Radiation Interactions in Extremes experimental facility (MaRIE), the 42-keV XFEL, with bursts of x-ray pulses at gigahertz repetition for studying fast dynamical processes, will help accelerate discovery and design of the advanced materials needed to meet 21st-century national security and energy security challenges. Yet the science of free-electron lasers has a long and distinguished history at Los Alamos National Laboratory (LANL), where for nearly four decades Los Alamos scientists have been performing research, design, development, and collaboration work in FEL science. The work at Los Alamos has evolved from low-gain amplifier and oscillator FEL development to highbrightness photoinjector development, and later, self-amplified spontaneous emission (SASE) and high-gain amplifier FEL development.

  20. Characterization and expression profiles of MaACS and MaACO genes from mulberry (Morus alba L.).

    PubMed

    Liu, Chang-ying; Lü, Rui-hua; Li, Jun; Zhao, Ai-chun; Wang, Xi-ling; Diane, Umuhoza; Wang, Xiao-hong; Wang, Chuan-hong; Yu, Ya-sheng; Han, Shu-mei; Lu, Cheng; Yu, Mao-de

    2014-07-01

    1-Aminocyclopropane-1-carboxylic acid synthase (ACS) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) are encoded by multigene families and are involved in fruit ripening by catalyzing the production of ethylene throughout the development of fruit. However, there are no reports on ACS or ACO genes in mulberry, partly because of the limited molecular research background. In this study, we have obtained five ACS gene sequences and two ACO gene sequences from Morus Genome Database. Sequence alignment and phylogenetic analysis of MaACO1 and MaACO2 showed that their amino acids are conserved compared with ACO proteins from other species. MaACS1 and MaACS2 are type I, MaACS3 and MaACS4 are type II, and MaACS5 is type III, with different C-terminal sequences. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) expression analysis showed that the transcripts of MaACS genes were strongly expressed in fruit, and more weakly in other tissues. The expression of MaACO1 and MaACO2 showed different patterns in various mulberry tissues. MaACS and MaACO genes demonstrated two patterns throughout the development of mulberry fruit, and both of them were strongly up-regulated by abscisic acid (ABA) and ethephon.

  1. The Cambridge Face Memory Test for Children (CFMT-C): a new tool for measuring face recognition skills in childhood.

    PubMed

    Croydon, Abigail; Pimperton, Hannah; Ewing, Louise; Duchaine, Brad C; Pellicano, Elizabeth

    2014-09-01

    Face recognition ability follows a lengthy developmental course, not reaching maturity until well into adulthood. Valid and reliable assessments of face recognition memory ability are necessary to examine patterns of ability and disability in face processing, yet there is a dearth of such assessments for children. We modified a well-known test of face memory in adults, the Cambridge Face Memory Test (Duchaine & Nakayama, 2006, Neuropsychologia, 44, 576-585), to make it developmentally appropriate for children. To establish its utility, we administered either the upright or inverted versions of the computerised Cambridge Face Memory Test - Children (CFMT-C) to 401 children aged between 5 and 12 years. Our results show that the CFMT-C is sufficiently sensitive to demonstrate age-related gains in the recognition of unfamiliar upright and inverted faces, does not suffer from ceiling or floor effects, generates robust inversion effects, and is capable of detecting difficulties in face memory in children diagnosed with autism. Together, these findings indicate that the CFMT-C constitutes a new valid assessment tool for children's face recognition skills.

  2. Hydrologic, Water-Quality, and Meteorological Data for the Cambridge, Massachusetts, Drinking-Water Source Area, Water Year 2005

    USGS Publications Warehouse

    Smith, Kirk P.

    2007-01-01

    Records of water quantity, water quality, and meteorological parameters were continuously collected from three reservoirs, two primary streams, and four subbasin tributaries in the Cambridge, Massachusetts, drinking-water source area during water year 2005 (October 2004 through September 2005). Water samples were collected during base-flow conditions and storms in the subbasins of the Cambridge Reservoir and Stony Brook Reservoir drainage areas and analyzed for selected elements, organic constituents, suspended sediment, and Escherichia coli bacteria. These data were collected to assist watershed administrators in managing the drinking-water source area and to identify potential sources of contaminants and trends in contaminant loading to the water supply. Monthly reservoir capacities for the Cambridge Reservoir varied from about 59 to 98 percent during water year 2005, while monthly reservoir capacities for the Stony Brook Reservoir and the Fresh Pond Reservoir were maintained at capacities greater than 84 and 96 percent, respectively. Assuming a water demand of 15 million gallons per day by the city of Cambridge, the volume of water released from the Stony Brook Reservoir to the Charles River during the 2005 water year is equivalent to an annual water surplus of about 119 percent. Recorded precipitation in the source area for the 2005 water year was within 2 inches of the total annual precipitation for the previous 2 water years. The monthly mean specific conductances for the outflow of the Cambridge Reservoir were similar to historical monthly mean values. However, monthly mean specific conductances for Stony Brook near Route 20, in Waltham (U.S. Geological Survey station 01104460), which is the principal tributary feeding the Stony Brook Reservoir, were generally higher than the medians of the monthly mean specific conductances for the period of record. Similarly, monthly mean specific conductances for a small tributary to Stony Brook (U.S. Geological Survey

  3. Identification and characterization of novel NuMA isoforms

    SciTech Connect

    Wu, Jin; Xu, Zhe; He, Dacheng; Lu, Guanting

    2014-11-21

    Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMA isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.

  4. The 300 mA SRF ERL

    SciTech Connect

    Ben-Zvi, Ilan

    2013-11-07

    Energy Recovery Linacs (ERL) are important for a variety of applications, from high-power Free-Electron Lasers (FEL) to polarized-electron polarized-proton colliders. The ERL current is arguably the most important characteristic of ERLs for such applications. With that in mind, the Collider-Accelerator Department at Brookhaven National Laboratory embarked on the development of a 300 mA ERL to serve as an R and D test-bed for high-current ERL technologies. These include high-current, extremely well damped superconducting accelerating cavities, high-current superconducting laser-photocathode electron guns and high quantum-efficiency photocathodes. In this presentation I will cover these ERL related developments.

  5. MIT jar test of the natural polymer chitosan with fresh pond water from the Cambridge Water Department, November-December 1992

    SciTech Connect

    Murcott, S.; Harleman, D.R.F.

    1993-01-01

    The purpose of the MIT (Massachusetts Institute of Technology) jar tests of chitosan using CWD (Cambridge Water Department Treatment Plant) water was to demonstrate the effectiveness of chitosan as a coagulant in drinking water applications. The approach was to compare the performance of the natural organic coagulant, chitosan, to the performance of alum and other chemical coagulants in terms of the parameters turbidity, color, pH and alkalinity. Twenty-five jar tests were conducted during November and December, 1992, at Parsons Laboratory, MIT, Cambridge, Massachusetts.

  6. Healthy travel and the socio-economic structure of car commuting in Cambridge, UK: a mixed-methods analysis.

    PubMed

    Goodman, Anna; Guell, Cornelia; Panter, Jenna; Jones, Natalia R; Ogilvie, David

    2012-06-01

    Car use is associated with substantial health and environmental costs but research in deprived populations indicates that car access may also promote psychosocial well-being within car-oriented environments. This mixed-method (quantitative and qualitative) study examined this issue in a more affluent setting, investigating the socio-economic structure of car commuting in Cambridge, UK. Our analyses involved integrating self-reported questionnaire data from 1142 participants in the Commuting and Health in Cambridge study (collected in 2009) and in-depth interviews with 50 participants (collected 2009-2010). Even in Britain's leading 'cycling city', cars were a key resource in bridging the gap between individuals' desires and their circumstances. This applied both to long-term life goals such as home ownership and to shorter-term challenges such as illness. Yet car commuting was also subject to constraints, with rush hour traffic pushing drivers to start work earlier and with restrictions on, or charges for, workplace parking pushing drivers towards multimodal journeys (e.g. driving to a 'park-and-ride' site then walking). These patterns of car commuting were socio-economically structured in several ways. First, the gradient of housing costs made living near Cambridge more expensive, affecting who could 'afford' to cycle and perhaps making cycling the more salient local marker of Bourdieu's class distinction. Nevertheless, cars were generally affordable in this relatively affluent, highly-educated population, reducing the barrier which distance posed to labour-force participation. Finally, having the option of starting work early required flexible hours, a form of job control which in Britain is more common among higher occupational classes. Following a social model of disability, we conclude that socio-economic advantage can make car-oriented environments less disabling via both greater affluence and greater job control, and in ways manifested across the full socio

  7. Superpartner mass measurement technique using 1D orthogonal decompositions of the Cambridge transverse mass variable M(T2).

    PubMed

    Konar, Partha; Kong, Kyoungchul; Matchev, Konstantin T; Park, Myeonghun

    2010-07-30

    We propose a new model-independent technique for mass measurements in missing energy events at hadron colliders. We illustrate our method with the most challenging case of a single-step decay chain. We consider inclusive same-sign chargino pair production in supersymmetry, followed by leptonic decays to sneutrinos χ+ χ+ → ℓ+ ℓ'+ ν(ℓ)ν(ℓ') and invisible decays ν(ℓ) → ν(ℓ) χ(1)(0). We introduce two one-dimensional decompositions of the Cambridge MT2 variable: M(T2∥) and M(T2⊥), on the direction of the upstream transverse momentum P→T and the direction orthogonal to it, respectively. We show that the sneutrino mass Mc can be measured directly by minimizing the number of events N(Mc) in which MT2 exceeds a certain threshold, conveniently measured from the end point M(T2⊥)(max) (Mc).

  8. Ma-huang strikes again: ephedrine nephrolithiasis.

    PubMed

    Powell, T; Hsu, F F; Turk, J; Hruska, K

    1998-07-01

    Ephedrine and its metabolites are naturally occurring alkaloids that can be derived from evergreens worldwide and have been used as medicinals for hundreds of years. Because they have "real" pharmacological alpha and beta catecholamine effects and are "natural" products, the alternative medicine industry has popularized them for multiple uses, including asthma, weight loss, energy and sexual enhancement, and euphoria. Several recent reviews have documented the dangerous nature of using these "drugs" unsupervised, including multiple deaths, and the FDA is currently reviewing ephedrine's use in the alternative medicine industry. We report a new toxicity, ephedrine nephrolithiasis, in a patient using an energy supplement, Ma-Huang extract, which contains ephedrine. Although previously not reported, the Louis C. Herring and Company kidney stone database show that this is an endemic complication of ephedrine with hundreds of previous episodes. Using gas chromatography (GC) mass spectrometry, we were able to positively identify the chemical structure of our patient's stone, as well as other similar stones from Louis Herring, as containing ephedrine, norephedrine, and pseudoephedrine.

  9. Changing the S and MA [Safety and Mission Assurance] Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W., Jr.

    2010-01-01

    Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

  10. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS...

  11. 42 CFR 422.520 - Prompt payment by MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.520 Prompt payment by MA organization. (a) Contract between CMS...

  12. Anatomic variations of the pancreatic duct and their relevance with the Cambridge classification system: MRCP findings of 1158 consecutive patients

    PubMed Central

    Adatepe, Mustafa; Imamoglu, Cetin; Esen, Ozgur Sipahi; Erkan, Nazif; Yildirim, Mehmet

    2016-01-01

    Abstract Background The study was conducted to evaluate the frequencies of the anatomic variations and the gender distributions of these variations of the pancreatic duct and their relevance with the Cambridge classification system as morphological sign of chronic pancreatitis using magnetic resonance cholangiopancreatography (MRCP). Patients and methods We retrospectively reviewed 1312 consecutive patients who referred to our department for MRCP between January 2013 and August 2015. We excluded 154 patients from the study because of less than optimal results due to imaging limitations or a history of surgery on pancreas. Finally a total of 1158 patients were included in the study. Results Among the 1158 patients included in the study, 54 (4.6%) patients showed pancreas divisum, 13 patients (1.2%) were defined as ansa pancreatica. When we evaluated the course of the pancreatic duct, we found the prevalence 62.5% for descending, 30% for sigmoid, 5.5% for vertical and 2% for loop. The most commonly observed pancreatic duct configuration was Type 3 in 528 patients (45.6%) where 521 patients (45%) had Type 1 configuration. Conclusions Vertical course (p = 0.004) and Type 2 (p = 0.03) configuration of pancreatic duct were more frequent in females than males. There were no statistically significant differences between the gender for the other pancreatic duct variations such as pancreas divisium, ansa pancreatica and course types other than vertical course (p > 0.05 for all). Variants of pancreas divisum and normal pancreatic duct variants were not associated with morphologic findings of chronic pancreatitis by using the Cambridge classification system. The ansa pancreatica is a rare type of anatomical variation of the pancreatic duct, which might be considered as a predisposing factor to the onset of idiopathic pancreatitis. PMID:27904444

  13. Individualized identification of euthymic bipolar disorder using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and machine learning

    PubMed Central

    Wu, Mon-Ju; Passos, Ives Cavalcante; Bauer, Isabelle E.; Lavagnino, Luca; Cao, Bo; Zunta-Soares, Giovana B.; Kapczinski, Flávio; Mwangi, Benson; Soares, Jair C.

    2016-01-01

    Background Previous studies have reported that patients with bipolar disorder (BD) present with cognitive impairments during mood episodes as well as euthymic phase. However, it is still unknown whether reported neurocognitive abnormalities can objectively identify individual BD patients from healthy controls (HC). Methods A total of 21 euthymic BD patients and 21 demographically matched HC were included in the current study. Participants performed the computerized Cambridge Neurocognitive Test Automated Battery (CANTAB) to assess cognitive performance. The least absolute shrinkage selection operator (LASSO) machine learning algorithm was implemented to identify neurocognitive signatures to distinguish individual BD patients from HC. Results The LASSO machine learning algorithm identified individual BD patients from HC with an accuracy of 71%, area under receiver operating characteristic curve of 0.7143 and significant at p = 0.0053. The LASSO algorithm assigned individual subjects with a probability score (0 – healthy, 1 – patient). Patients with rapid cycling (RC) were assigned increased probability scores as compared to patients without RC. A multivariate pattern of neurocognitive abnormalities comprising of affective Go/No-go and the Cambridge gambling task was relevant in distinguishing individual patients from HC. Limitations Our study sample was small as we only considered euthymic BD patients and demographically matched HC. Conclusion Neurocognitive abnormalities can distinguish individual euthymic BD patients from HC with relatively high accuracy. In addition, patients with RC had more cognitive impairments compared to patients without RC. The predictive neurocognitive signature identified in the current study can potentially be used to provide individualized clinical inferences on BD patients. PMID:26748737

  14. A comparison of three infant skinfold reference standards: Tanner-Whitehouse, Cambridge Infant Growth Study, and WHO Child Growth Standards.

    PubMed

    Miller, Elizabeth M

    2015-10-01

    As researchers increasingly focus on early infancy as a critical period of development, there is a greater need for methodological tools that can address all aspects of infant growth. Infant skinfold measures, in particular, are measurements in need of reliable reference standards that encompass all ages of infants and provide an accurate assessment of the relative fatness of a population. This report evaluates three published reference standards for infant skinfold measurements: Tanner-Whitehouse, Cambridge Infant Growth Study, and the World Health Organization (WHO) Child Growth Standards. To assess these standards, triceps skinfolds from a population of rural Kenyan infants (n = 250) and triceps skinfolds and subscapular skinfolds from infants in the National Health and Nutrition Examination Survey 1999-2002 (NHANES; n = 1197) were calculated as z-scores from the lambda-mu-sigma curves provided by each reference population. The Tanner-Whitehouse standards represented both the Kenyan and US populations as lean, while the Cambridge standards represented both populations as overfat. The distribution of z-scores based on the WHO standards fell in the middle, but excluded infants from both populations who were below the age of 3 months. Based on these results, the WHO reference standard is the best skinfold reference standard for infants over the age of 3 months. For populations with infants of all ages, the Tanner-Whitehouse standards are recommended, despite representing both study populations as underfat. Ideally, the WHO will extend their reference standard to include infants between the ages of 0 and 3 months.

  15. Calmodulin disrupts the structure of the HIV-1 MA protein†

    PubMed Central

    Chow, John Y. H.; Jeffries, Cy M.; Kwan, Ann H.; Guss, J. Mitchell; Trewhella, Jill

    2010-01-01

    The MA protein from HIV-1 is a small, multifunctional protein responsible for regulating various stages of the viral replication cycle. To achieve its diverse tasks MA interacts with host cell proteins and it has been reported that one of these is the ubiquitous calcium -sensing calmodulin (CaM) which is up-regulated upon HIV-1 infection. The nature of the CaM-MA interaction has been the subject of structural studies using peptides based on the MA sequence that have led to conflicting conclusions. The results presented here show that CaM binds intact MA with 1:1 stoichiometry in a Ca2+-dependent manner and that the complex adopts a highly extended conformation in solution as revealed by small-angle X-ray scattering. Alterations in tryptophan fluorescence suggest that the two tryptophans at the N-terminus of MA mediate the CaM interaction. Major chemical shift changes occur in the NMR spectrum of MA upon complex formation, while chemical shift changes in the CaM spectrum are quite modest and are assigned to residues within the target-protein binding hydrophobic clefts of CaM. The NMR data indicate that CaM binds MA via its N-and C-terminal lobes and induces a dramatic conformational change involving a significant loss of secondary and tertiary structure within MA. Circular dichroism experiments suggest that MA looses ~20% of its α-helical content upon CaM binding. Thus CaM binding is expected to impact upon the accessibility of interaction sites within MA that are involved in its various functions. PMID:20488189

  16. Surface-water, water-quality, and meteorological data for the Cambridge, Massachusetts, drinking-water source area, water years 2007-08

    USGS Publications Warehouse

    Smith, Kirk P.

    2011-01-01

    Water samples were collected in nearly all of the subbasins in the Cambridge drinking-water source area and from Fresh Pond during the study period. Discrete water samples were collected during base-flow conditions with an antecedent dry period of at least 3 days. Composite sampl

  17. Performance on Cambridge Neuropsychological Test Automated Battery Subtests Sensitive to Frontal Lobe Function in People with Autistic Disorder: Evidence from the Collaborative Programs of Excellence in Autism Network

    ERIC Educational Resources Information Center

    Ozonoff, Sally; Cook, Ian; Coon, Hilary; Dawson, Geraldine; Joseph, Robert M.; Klin, Ami; McMahon, William M.; Minshew, Nancy; Munson, Jeffrey A.

    2004-01-01

    Recent structural and functional imaging work, as well as neuropathology and neuropsychology studies, provide strong empirical support for the involvement of frontal cortex in autism. The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computer-administered set of neuropsychological tests developed to examine specific components…

  18. Teaching Three-Dimensional Structural Chemistry Using Crystal Structure Databases. 2. Teaching Units that Utilize an Interactive Web-Accessible Subset of the Cambridge Structural Database

    ERIC Educational Resources Information Center

    Battle, Gary M.; Allen, Frank H.; Ferrence, Gregory M.

    2010-01-01

    A series of online interactive teaching units have been developed that illustrate the use of experimentally measured three-dimensional (3D) structures to teach fundamental chemistry concepts. The units integrate a 500-structure subset of the Cambridge Structural Database specially chosen for their pedagogical value. The units span a number of key…

  19. Teaching Three-Dimensional Structural Chemistry Using Crystal Structure Databases. 4. Examples of Discovery-Based Learning Using the Complete Cambridge Structural Database

    ERIC Educational Resources Information Center

    Battle, Gary M.; Allen, Frank H.; Ferrence, Gregory M.

    2011-01-01

    Parts 1 and 2 of this series described the educational value of experimental three-dimensional (3D) chemical structures determined by X-ray crystallography and retrieved from the crystallographic databases. In part 1, we described the information content of the Cambridge Structural Database (CSD) and discussed a representative teaching subset of…

  20. Teaching Three-Dimensional Structural Chemistry Using Crystal Structure Databases. 3. The Cambridge Structural Database System: Information Content and Access Software in Educational Applications

    ERIC Educational Resources Information Center

    Battle, Gary M.; Allen, Frank H.; Ferrence, Gregory M.

    2011-01-01

    Parts 1 and 2 of this series described the educational value of experimental three-dimensional (3D) chemical structures determined by X-ray crystallography and retrieved from the crystallographic databases. In part 1, we described the information content of the Cambridge Structural Database (CSD) and discussed a representative teaching subset of…

  1. Comparative Coh-Metrix Analysis of Reading Comprehension Texts: Unified (Russian) State Exam in English vs. Cambridge First Certificate in English

    ERIC Educational Resources Information Center

    Solnyshkina, Marina I.; Harkova, Elena V.; Kiselnikov, Aleksander S.

    2014-01-01

    The article summarizes the results of the comparative study of Reading comprehension texts used in B2 level tests: Unified (Russia) State Exam in English (EGE) and Cambridge First Certificate in English (FCE). The research conducted was mainly focused on six parameters measured with the Coh-Metrix, a computational tool producing indices of the…

  2. Banana Transcription Factor MaERF11 Recruits Histone Deacetylase MaHDA1 and Represses the Expression of MaACO1 and Expansins during Fruit Ripening1[OPEN

    PubMed Central

    Han, Yan-Chao; Kuang, Jian-Fei; Xiao, Yun-Yi; Fu, Chang-Chun; Wang, Jun-Ning

    2016-01-01

    Phytohormone ethylene controls diverse developmental and physiological processes such as fruit ripening via modulation of ethylene signaling pathway. Our previous study identified that ETHYLENE RESPONSE FACTOR11 (MaERF11), a transcription factor in the ethylene signaling pathway, negatively regulates the ripening of banana, but the mechanism for the MaERF11-mediated transcriptional regulation remains largely unknown. Here we showed that MaERF11 has intrinsic transcriptional repression activity in planta. Electrophoretic mobility shift assay and chromatin immunoprecipitation analyses demonstrated that MaERF11 binds to promoters of three ripening-related Expansin genes, MaEXP2, MaEXP7 and MaEXP8, as well as an ethylene biosynthetic gene MaACO1, via the GCC-box motif. Furthermore, expression patterns of MaACO1, MaEXP2, MaEXP7, and MaEXP8 genes are correlated with the changes of histone H3 and H4 acetylation level during fruit ripening. Moreover, we found that MaERF11 physically interacts with a histone deacetylase, MaHDA1, which has histone deacetylase activity, and the interaction significantly strengthens the MaERF11-mediated transcriptional repression of MaACO1 and Expansins. Taken together, these findings suggest that MaERF11 may recruit MaHDA1 to its target genes and repress their expression via histone deacetylation. PMID:27208241

  3. 42 CFR 422.103 - Benefits under an MA MSA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Benefits under an MA MSA plan. 422.103 Section 422... Benefits under an MA MSA plan. (a) General rule. An MA organization offering an MA MSA plan must make...) Countable expenses. An MA organization offering an MA MSA plan must count toward the annual deductible...

  4. MaROS: Information Management Service

    NASA Technical Reports Server (NTRS)

    Allard, Daniel A.; Gladden, Roy E.; Wright, Jesse J.; Hy, Franklin H.; Rabideau, Gregg R.; Wallick, Michael N.

    2011-01-01

    This software is provided by the Mars Relay Operations Service (MaROS) task to a variety of Mars projects for the purpose of coordinating communications sessions between landed spacecraft assets and orbiting spacecraft assets at Mars. The Information Management Service centralizes a set of functions previously distributed across multiple spacecraft operations teams, and as such, greatly improves visibility into the end-to-end strategic coordination process. Most of the process revolves around the scheduling of communications sessions between the spacecraft during periods of time when a landed asset on Mars is geometrically visible by an orbiting spacecraft. These relay sessions are used to transfer data both to and from the landed asset via the orbiting asset on behalf of Earth-based spacecraft operators. This software component is an application process running as a Java virtual machine. The component provides all service interfaces via a Representational State Transfer (REST) protocol over https to external clients. There are two general interaction modes with the service: upload and download of data. For data upload, the service must execute logic specific to the upload data type and trigger any applicable calculations including pass delivery latencies and overflight conflicts. For data download, the software must retrieve and correlate requested information and deliver to the requesting client. The provision of this service enables several key advancements over legacy processes and systems. For one, this service represents the first time that end-to-end relay information is correlated into a single shared repository. The software also provides the first multimission latency calculator; previous latency calculations had been performed on a mission-by-mission basis.

  5. 46 CFR 308.544 - Facultative binder, Form MA-315.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Facultative binder, Form MA-315. 308.544 Section 308.544... Risk Cargo Insurance Iii-Facultative War Risk Cargo Insurance § 308.544 Facultative binder, Form MA-315. The standard form of War Risk Facultative Cargo Binder, which may be obtained from the American...

  6. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Standards for MA organization marketing. 422.2268... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2268 Standards for MA organization marketing. In conducting marketing activities,...

  7. MA-9 PILOT L. GORDON COOPER INSIDE HIS MERCURY SPACECRAFT

    NASA Technical Reports Server (NTRS)

    1963-01-01

    MA-9 PILOT L. GORDON COOPER INSIDE HIS MERCURY SPACECRAFT S-63-6129 P-07144, ARCHIVE-03810 MA-9 pilot, L. Gordon Cooper, inside his Mercury spacecraft runs through one of the numerous pre-flight checks surrounded by dials, switches, indicators and buttons representing the complciated engineering technology of the space age.

  8. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... conditions, including mental illness and developmental disabilities. In addition, the MA organization must... 42 Public Health 3 2010-10-01 2010-10-01 false Disenrollment by the MA organization. 422.74 Section 422.74 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND...

  9. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... use of electronic health records. (c) Phase-out of the indirect costs of medical education from MA... 42 Public Health 3 2010-10-01 2010-10-01 false Annual MA capitation rates. 422.306 Section 422.306 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN...

  10. 46 CFR 308.550 - Certificate, Form MA-320.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.550 Certificate, Form MA-320. Wherever any provision of this... MA-320-C for a corporation, which forms may be obtained from the American War Risk Agency or MARAD....

  11. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Closing report, Form MA-313. 308.533 Section 308.533 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313....

  12. 17 CFR 240.15Ba1-5 - Amendments to Form MA and Form MA-I.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Amendments to Form MA and Form MA-I. 240.15Ba1-5 Section 240.15Ba1-5 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) GENERAL RULES AND REGULATIONS, SECURITIES EXCHANGE ACT OF 1934 Rules and...

  13. Sediment Flux from Stratigraphy: Insights from <1 Ma to >300 Ma Sedimentary Archives

    NASA Astrophysics Data System (ADS)

    Romans, B.; Mason, C. C.; Eriksson, K. A.

    2014-12-01

    Tectonic or climate signals that originate in net-erosional catchments are transmitted down-system as sediment. The accumulation of that sediment in net-depositional regions and preservation as stratigraphy can be accessed and used to reconstruct signal generation and propagation. Studies of modern to <20 ka sedimentary systems suggest that signal propagation (or lack thereof) is, in part, controlled by the size, relief, and other morphologic characteristics of sediment-production segments. Thus, it's critical to measure, estimate, or infer aspects of the feeder catchment when reconstructing system behavior from sedimentary deposits. Here, we present results from two studies aimed at determining paleo-sediment flux from stratigraphic archives. The first study uses outcropping middle Pleistocene (~0.6 Ma) alluvial-fan deposits in the Panamint Mountains, California, to investigate the relationship of sediment supply to stratigraphic architecture in a small catchment-fan system. The youth of this system allows us to estimate fan volumes from facies architecture and depositional system dimensions based on catchment-area to fan-area relationships of nearby modern systems. These data, combined with preliminary cosmogenic radionuclide-derived paleo-denudation rates, provide an opportunity to examine the nature of erosional signal propagation. The second study examines much older, Upper Mississippian (~325 Ma), fluvial and deltaic strata. Absolute chronologic tools to calculate centennial-millennial rates in deep-time sedimentary archives do not yet exist. Here, we use the extraordinary tidal rhythmite deposits of the Pride Shale in the Appalachian Basin as a high-resolution chronometer to constrain the duration of basin filling. We then use the scale of fluvial channel bodies in the underlying and overlying units combined with climate-specific empirical relationships derived from modern systems to estimate the size of the paleo-catchment. The resultant estimates of

  14. Applicability of the Calgary-Cambridge Guide to Dog and Cat Owners for Teaching Veterinary Clinical Communications.

    PubMed

    Englar, Ryane E; Williams, Melanie; Weingand, Kurt

    2016-01-01

    Effective communication in health care benefits patients. Medical and veterinary schools not only have a responsibility to teach communication skills, the American Veterinary Medical Association (AVMA) Council on Education (COE) requires that communication be taught in all accredited colleges of veterinary medicine. However, the best strategy for designing a communications curriculum is unclear. The Calgary-Cambridge Guide (CCG) is one of many models developed in human medicine as an evidence-based approach to structuring the clinical consultation through 71 communication skills. The model has been revised by Radford et al. (2006) for use in veterinary curricula; however, the best approach for veterinary educators to teach communication remains to be determined. This qualitative study investigated if one adaptation of the CCG currently taught at Midwestern University College of Veterinary Medicine (MWU CVM) fulfills client expectations of what constitutes clinically effective communication. Two focus groups (cat owners and dog owners) were conducted with a total of 13 participants to identify common themes in veterinary communication. Participants compared communication skills they valued to those taught by MWU CVM. The results indicated that while the CCG skills that MWU CVM adopted are applicable to cat and dog owners, they are not comprehensive. Participants expressed the need to expand the skillset to include compassionate transparency and unconditional positive regard. Participants also expressed different communication needs that were attributed to the species of companion animal owned.

  15. Discrimination thresholds of normal and anomalous trichromats: Model of senescent changes in ocular media density on the Cambridge Colour Test

    PubMed Central

    Shinomori, Keizo; Panorgias, Athanasios; Werner, John S.

    2017-01-01

    Age-related changes in chromatic discrimination along dichromatic confusion lines were measured with the Cambridge Colour Test (CCT). One hundred and sixty-two individuals (16 to 88 years old) with normal Rayleigh matches were the major focus of this paper. An additional 32 anomalous trichromats classified by their Rayleigh matches were also tested. All subjects were screened to rule out abnormalities of the anterior and posterior segments. Thresholds on all three chromatic vectors measured with the CCT showed age-related increases. Protan and deutan vector thresholds increased linearly with age while the tritan vector threshold was described with a bilinear model. Analysis and modeling demonstrated that the nominal vectors of the CCT are shifted by senescent changes in ocular media density, and a method for correcting the CCT vectors is demonstrated. A correction for these shifts indicates that classification among individuals of different ages is unaffected. New vector thresholds for elderly observers and for all age groups are suggested based on calculated tolerance limits. PMID:26974943

  16. Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour Test.

    PubMed

    Moura, Ana Laura de Araújo; Teixeira, Rosani Aparecida Antunes; Oiwa, Nestor N; Costa, Marcelo F; Feitosa-Santana, Claudia; Callegaro, Dagoberto; Hamer, Russell D; Ventura, Dora Fix

    2008-01-01

    We assessed chromatic discrimination in multiple sclerosis (MS) patients both with (ON) and without (no ON) a history of optic neuritis using the Cambridge color test (CCT). Our goal was to determine the magnitude and chromatic axes of any color vision losses in both patient groups, and to evaluate age-related changes in chromatic discrimination in both patient groups compared to normals. Using the CCT, we measured chromatic discrimination along the protan, deutan and tritan axes in 35 patients with MS (17 ON eyes) and 74 age matched controls. Color thresholds for both patient groups were significantly higher than controls' along the protan and tritan axes (p < 0.001). In addition, the ON and no-ON groups differed significantly along all three-color axes (p < 0.001). MS patients presented a progressive color discrimination impairment with age (along the deutan and tritan axes) that was almost two times faster than controls, even in the absence of ON. These findings suggest that demyelinating diseases reduce sensitivity to color vision in both red-green and blue-yellow axes, implying impairment in both parvocellular and koniocellular visual pathways. The CCT is a useful tool to help characterize vision losses in MS, and the relationship between these losses and degree of optic nerve involvement.

  17. Robust associations between the 20-item prosopagnosia index and the Cambridge Face Memory Test in the general population

    PubMed Central

    Bird, Geoffrey

    2017-01-01

    Developmental prosopagnosia (DP) is a neurodevelopmental condition, characterized by lifelong face recognition deficits. Leading research groups diagnose the condition using complementary computer-based tasks and self-report measures. In an attempt to standardize the reporting of self-report evidence, we recently developed the 20-item prosopagnosia index (PI20), a short questionnaire measure of prosopagnosic traits suitable for screening adult samples for DP. Strong correlations between scores on the PI20 and performance on the Cambridge Face Memory Test (CFMT) appeared to confirm that individuals possess sufficient insight into their face recognition ability to complete a self-report measure of prosopagnosic traits. However, the extent to which people have insight into their face recognition abilities remains contentious. A lingering concern is that feedback from formal testing, received prior to administration of the PI20, may have augmented the self-insight of some respondents in the original validation study. To determine whether the significant correlation with the CFMT was an artefact of previously delivered feedback, we sought to replicate the validation study in individuals with no history of formal testing. We report highly significant correlations in two independent samples drawn from the general population, confirming: (i) that a significant relationship exists between PI20 scores and performance on the CFMT, and (ii) that this is not dependent on the inclusion of individuals who have previously received feedback. These findings support the view that people have sufficient insight into their face recognition abilities to complete a self-report measure of prosopagnosic traits.

  18. Discrimination thresholds of normal and anomalous trichromats: Model of senescent changes in ocular media density on the Cambridge Colour Test.

    PubMed

    Shinomori, Keizo; Panorgias, Athanasios; Werner, John S

    2016-03-01

    Age-related changes in chromatic discrimination along dichromatic confusion lines were measured with the Cambridge Colour Test (CCT). One hundred and sixty-two individuals (16 to 88 years old) with normal Rayleigh matches were the major focus of this paper. An additional 32 anomalous trichromats classified by their Rayleigh matches were also tested. All subjects were screened to rule out abnormalities of the anterior and posterior segments. Thresholds on all three chromatic vectors measured with the CCT showed age-related increases. Protan and deutan vector thresholds increased linearly with age while the tritan vector threshold was described with a bilinear model. Analysis and modeling demonstrated that the nominal vectors of the CCT are shifted by senescent changes in ocular media density, and a method for correcting the CCT vectors is demonstrated. A correction for these shifts indicates that classification among individuals of different ages is unaffected. New vector thresholds for elderly observers and for all age groups are suggested based on calculated tolerance limits.

  19. Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural Database.

    PubMed

    Hawkins, Paul C D; Skillman, A Geoffrey; Warren, Gregory L; Ellingson, Benjamin A; Stahl, Matthew T

    2010-04-26

    Here, we present the algorithm and validation for OMEGA, a systematic, knowledge-based conformer generator. The algorithm consists of three phases: assembly of an initial 3D structure from a library of fragments; exhaustive enumeration of all rotatable torsions using values drawn from a knowledge-based list of angles, thereby generating a large set of conformations; and sampling of this set by geometric and energy criteria. Validation of conformer generators like OMEGA has often been undertaken by comparing computed conformer sets to experimental molecular conformations from crystallography, usually from the Protein Databank (PDB). Such an approach is fraught with difficulty due to the systematic problems with small molecule structures in the PDB. Methods are presented to identify a diverse set of small molecule structures from cocomplexes in the PDB that has maximal reliability. A challenging set of 197 high quality, carefully selected ligand structures from well-solved models was obtained using these methods. This set will provide a sound basis for comparison and validation of conformer generators in the future. Validation results from this set are compared to the results using structures of a set of druglike molecules extracted from the Cambridge Structural Database (CSD). OMEGA is found to perform very well in reproducing the crystallographic conformations from both these data sets using two complementary metrics of success.

  20. Color vision impairment in type 2 diabetes assessed by the D-15d test and the Cambridge Colour Test.

    PubMed

    Feitosa-Santana, Claudia; Paramei, Galina V; Nishi, Mauro; Gualtieri, Mirella; Costa, Marcelo F; Ventura, Dora F

    2010-09-01

    Color vision impairment emerges at early stages of diabetes mellitus type 2 (DM2) and may precede diabetic retinopathy or the appearance of vascular alterations in the retina. The aim of the present study was to compare the evaluation of the color vision with two different tests - the Lanthony desaturated D-15d test (a traditional color arrangement test), and the Cambridge Colour Test (CCT) (a computerized color discrimination test) - in patients diagnosed with DM2 without clinical signs of diabetic retinopathy (DR), and in sex- and age-matched control groups. Both color tests revealed statistically significant differences between the controls and the worst eyes of the DM2 patients. In addition, the degree of color vision impairment diagnosed by both tests correlated with the disease duration. The D-15d outcomes indicated solely tritan losses. In comparison, CCT outcomes revealed diffuse losses in color discrimination: 13.3% for best eyes and 29% for worst eyes. In addition, elevation of tritan thresholds in the DM2 patients, as detected by the Trivector subtest of the CCT, was found to correlate with the level of glycated hemoglobin. Outcomes of both tests confirm that subclinical losses of color vision are present in DM2 patients at an early stage of the disease, prior to signs of retinopathy. Considering the advantages of the CCT test compared to the D-15d test, further studies should attempt to verify and/or improve the efficiency of the CCT test.

  1. Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.

    PubMed

    Spencer, John; Coaker, Hannah

    2015-01-01

    The SelectBio 2015: Academic Drug Discovery Conference was held in Cambridge, UK, on 19-20 May 2015. Building on the success of academic drug discovery events in the USA, this conference aimed to showcase the exciting new research emerging from academic drug discovery and to help bridge the gap between basic research and commercial application. At the event the authors heard from a number of speakers on a broad array of topics, from partnering models for academia and industry to novel drug discovery approaches across various therapeutic areas, with a few talks, such as those by Susanne Muller-Knapp (Structure Genomics Consortium, Oxford University, Oxford, UK) and Julian Blagg (Institute of Cancer Research, UK), covering both remits, by highlighting a number of such partnerships and then delving into some case studies. The conference concluded with a heated debate on whether phenotypic discovery should be favored over targeted discovery in academia and pharma, in a panel discussion chaired by Roland Wolkowicz (San Diego State University, USA).

  2. Kinetics of Cyclic Oxidation and Cracking and Finite Element Analysis of MA956 and Sapphire/MA956 Composite System

    NASA Technical Reports Server (NTRS)

    Lee, Kang N.; Arya, Vinod K.; Halford, Gary R.; Barrett, Charles A.

    1996-01-01

    Sapphire fiber-reinforced MA956 composites hold promise for significant weight savings and increased high-temperature structural capability, as compared to unreinforced MA956. As part of an overall assessment of the high-temperature characteristics of this material system, cyclic oxidation behavior was studied at 1093 C and 1204 C. Initially, both sets of coupons exhibited parabolic oxidation kinetics. Later, monolithic MA956 exhibited spallation and a linear weight loss, whereas the composite showed a linear weight gain without spallation. Weight loss of the monolithic MA956 resulted from the linking of a multiplicity of randomly oriented and closely spaced surface cracks that facilitated ready spallation. By contrast, cracking of the composite's oxide layer was nonintersecting and aligned nominally parallel with the orientation of the subsurface reinforcing fibers. Oxidative lifetime of monolithic MA956 was projected from the observed oxidation kinetics. Linear elastic, finite element continuum, and micromechanics analyses were performed on coupons of the monolithic and composite materials. Results of the analyses qualitatively agreed well with the observed oxide cracking and spallation behavior of both the MA956 and the Sapphire/MA956 composite coupons.

  3. RadNet Air Data From Worcester, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Worcester, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  4. RadNet Air Data From Boston, MA

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Boston, MA from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  5. HoCaMA: Home Care Hybrid Multiagent Architecture

    NASA Astrophysics Data System (ADS)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  6. The banana fruit Dof transcription factor MaDof23 acts as a repressor and interacts with MaERF9 in regulating ripening-related genes.

    PubMed

    Feng, Bi-hong; Han, Yan-chao; Xiao, Yun-yi; Kuang, Jian-fei; Fan, Zhong-qi; Chen, Jian-ye; Lu, Wang-jin

    2016-04-01

    The DNA binding with one finger (Dof) proteins, a family of plant-specific transcription factors, are involved in a variety of plant biological processes. However, little information is available on their involvement in fruit ripening. We have characterized 25 MaDof genes from banana fruit (Musa acuminata), designated as MaDof1-MaDof25 Gene expression analysis in fruit subjected to different ripening conditions revealed that MaDofs were differentially expressed during different stages of ripening. MaDof10, 23, 24, and 25 were ethylene-inducible and nuclear-localized, and their transcript levels increased during fruit ripening. Moreover, yeast two-hybrid and bimolecular fluorescence complementation analyses demonstrated a physical interaction between MaDof23 and MaERF9, a potential regulator of fruit ripening reported in a previous study. We determined that MaDof23 is a transcriptional repressor, whereas MaERF9 is a transcriptional activator. We suggest that they might act antagonistically in regulating 10 ripening-related genes, including MaEXP1/2/3/5, MaXET7, MaPG1, MaPME3, MaPL2, MaCAT, and MaPDC, which are associated with cell wall degradation and aroma formation. Taken together, our findings provide new insight into the transcriptional regulation network controlling banana fruit ripening.

  7. The banana fruit Dof transcription factor MaDof23 acts as a repressor and interacts with MaERF9 in regulating ripening-related genes

    PubMed Central

    Feng, Bi-hong; Han, Yan-chao; Xiao, Yun-yi; Kuang, Jian-fei; Fan, Zhong-qi; Chen, Jian-ye; Lu, Wang-jin

    2016-01-01

    The DNA binding with one finger (Dof) proteins, a family of plant-specific transcription factors, are involved in a variety of plant biological processes. However, little information is available on their involvement in fruit ripening. We have characterized 25 MaDof genes from banana fruit (Musa acuminata), designated as MaDof1–MaDof25. Gene expression analysis in fruit subjected to different ripening conditions revealed that MaDofs were differentially expressed during different stages of ripening. MaDof10, 23, 24, and 25 were ethylene-inducible and nuclear-localized, and their transcript levels increased during fruit ripening. Moreover, yeast two-hybrid and bimolecular fluorescence complementation analyses demonstrated a physical interaction between MaDof23 and MaERF9, a potential regulator of fruit ripening reported in a previous study. We determined that MaDof23 is a transcriptional repressor, whereas MaERF9 is a transcriptional activator. We suggest that they might act antagonistically in regulating 10 ripening-related genes, including MaEXP1/2/3/5, MaXET7, MaPG1, MaPME3, MaPL2, MaCAT, and MaPDC, which are associated with cell wall degradation and aroma formation. Taken together, our findings provide new insight into the transcriptional regulation network controlling banana fruit ripening. PMID:26889012

  8. 42 CFR 422.455 - Special rules for MA Regional Plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., especially those residing in rural areas. (4) Market survey and analysis. Before establishing MA regions, CMS....455 Special rules for MA Regional Plans. (a) Coverage of entire MA region. The service area for an MA regional plan will consist of an entire MA region established under paragraph (b) of this section, and...

  9. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1) Initial... enrolled in an MA-PD plan may elect another MA-PD plan or original Medicare and coverage under a PDP. Such... individual may not elect an MA-PD plan or coverage under a PDP. (ii) Newly eligible MA individual....

  10. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Eligibility to elect an MA plan. For this subpart, all references to an MA plan include MA-PD and both MA... individual is eligible to elect an MA plan if he or she— (1) Is entitled to Medicare under Part A...

  11. MaRIE theory, modeling and computation roadmap executive summary

    SciTech Connect

    Lookman, Turab

    2010-01-01

    The confluence of MaRIE (Matter-Radiation Interactions in Extreme) and extreme (exascale) computing timelines offers a unique opportunity in co-designing the elements of materials discovery, with theory and high performance computing, itself co-designed by constrained optimization of hardware and software, and experiments. MaRIE's theory, modeling, and computation (TMC) roadmap efforts have paralleled 'MaRIE First Experiments' science activities in the areas of materials dynamics, irradiated materials and complex functional materials in extreme conditions. The documents that follow this executive summary describe in detail for each of these areas the current state of the art, the gaps that exist and the road map to MaRIE and beyond. Here we integrate the various elements to articulate an overarching theme related to the role and consequences of heterogeneities which manifest as competing states in a complex energy landscape. MaRIE experiments will locate, measure and follow the dynamical evolution of these heterogeneities. Our TMC vision spans the various pillar science and highlights the key theoretical and experimental challenges. We also present a theory, modeling and computation roadmap of the path to and beyond MaRIE in each of the science areas.

  12. Increase in physical activities in kindergarten children with cerebral palsy by employing MaKey-MaKey-based task systems.

    PubMed

    Lin, Chien-Yu; Chang, Yu-Ming

    2014-09-01

    In this study, we employed Flash- and Scratch-based multimedia by using a MaKey-MaKey-based task system to increase the motivation level of children with cerebral palsy to perform physical activities. MaKey MaKey is a circuit board that converts physical touch to a digital signal, which is interpreted by a computer as a keyboard message. In this study, we used conductive materials to control this interaction. This study followed single-case design using ABAB models in which A indicated the baseline and B indicated the intervention. The experiment period comprised 1 month and a half. The experimental results demonstrated that in the case of two kindergarten children with cerebral palsy, their scores were considerably increased during the intervention phrases. The developmental applications of the results are also discussed.

  13. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA... the Act. (2) Payments to MA-PD organizations for statutory drug benefits provided under this title...

  14. 42 CFR 422.322 - Source of payment and effect of MA plan election on payment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... payments. (1) Payments under this subpart for original fee-for-service benefits to MA organizations or MA... the Act. (2) Payments to MA-PD organizations for statutory drug benefits provided under this title...

  15. Adaptation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) into French-Canadian and English-Canadian

    PubMed Central

    Coffin, Donna; Duval, Karine; Martel, Simon; Granton, John; Lefebvre, Marie-Claude; Meads, David M; Twiss, James; McKenna, Stephen P

    2008-01-01

    BACKGROUND: The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is the first disease-specific instrument for assessing patient-reported symptoms, functioning and quality of life (QoL) in pulmonary arterial hypertension (PAH). OBJECTIVES: To create and validate French-Canadian (FC) and English-Canadian (EC) language versions of the CAMPHOR. METHODS: A translation panel (for the FC version) and lay panels (for both versions) were convened to adapt the questionnaires (dual-panel methodology). Subsequently, these new questionnaires were field-tested in 15 FC PAH and 15 EC PAH patients. Finally, in a postal validation study, the new language versions of the CAMPHOR underwent psychometric evaluation in 41 FC and 52 EC PAH patients to test for reliability and validity. RESULTS: The FC and EC field-test interview participants found the questionnaires relevant, comprehensible and easy to complete. Psychometric analyses showed that the FC and EC adaptations were successful. High test-retest coefficients for the scales after controlling for change in respondent’s QoL (FC: 0.92 to 0.96; EC: 0.85 to 0.99) indicated a high degree of reliability. The FC and EC CAMPHOR scales had good internal consistency (Cronbach’s alpha coefficients 0.90 to 0.92 and 0.88 to 0.92, respectively). Predicted correlations with the Nottingham Health Profile provided evidence of the construct validity of the FC and EC scales. The FC and EC adaptations also showed known groups validity. CONCLUSIONS: The FC and EC adaptations of the CAMPHOR have been shown to be reliable and valid for measures of health-related QoL and QoL in PAH, and thus can be recommended for use in clinical studies and routine practice in PAH. PMID:18354747

  16. Molecular evolution of the Sorghum Maturity Gene Ma3.

    PubMed

    Wang, Yan; Tan, Lubin; Fu, Yongcai; Zhu, Zuofeng; Liu, Fengxia; Sun, Chuanqing; Cai, Hongwei

    2015-01-01

    Time to maturity is a critical trait in sorghum (Sorghum bicolor) breeding, as it determines whether a variety can be grown in a particular cropping system or ecosystem. Understanding the nucleotide variation and the mechanisms of molecular evolution of the maturity genes would be helpful for breeding programs. In this study, we analyzed the nucleotide diversity of Ma3, an important maturity gene in sorghum, using 252 cultivated and wild sorghum materials from all over the world. The nucleotide variation and diversity were analyzed based both on race- and usage-based groups. We also sequenced 12 genes around the Ma3 gene in 185 of these materials to search for a selective sweep and found that purifying selection was the strongest force on Ma3, as low nucleotide diversity and low-frequency amino acid variants were observed. However, a very special mutation, described as ma3R, seemed to be under positive selection, as indicated by dramatically reduced nucleotide variation not only at the loci but also in the surrounding regions among individuals carrying the mutations. In addition, in an association study using the Ma3 nucleotide variations, we detected 3 significant SNPs for the heading date at a high-latitude environment (Beijing) and 17 at a low-latitude environment (Hainan). The results of this study increases our understanding of the evolutionary mechanisms of the maturity genes in sorghum and will be useful in sorghum breeding.

  17. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    NASA Astrophysics Data System (ADS)

    Bundy, Kevin

    2015-04-01

    I describe a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory). One of three core programs in the 6-year SDSS-IV project† that began on July 1st, 2014, MaNGA will deploy 17 fiber-bundle IFUs across the Sloan 2.5m Telescope's 3 degree field-of-view, targeting a mass-selected sample with a median redshift of 0.03, typical spatial resolution of 1-2 kpc, and a per-fiber signal-to-noise ratio of 4-8 in the outskirts of target galaxies. For each galaxy in the sample, MaNGA will provide maps and measured gradients of the composition and dynamics of both stars and gas. I discuss early results that highlight MaNGA's potential to shed light on the ionization and chemical enrichment of gas in galaxies, spatial patterns in their star formation histories, and the internal makeup of stellar populations. MaNGA's unprecedented data set will not only provide powerful new insight on galaxy formation and evolution but will serve as a valuable benchmark for future high-z observations from large telescopes and space-based facilities.

  18. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    NASA Astrophysics Data System (ADS)

    Bundy, Kevin

    2015-01-01

    I present the design and execution of a new survey to obtain resolved spectroscopy for 10,000 nearby galaxies called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory). One of three core programs in the 6-year SDSS-IV project that began on July 1st, 2014, MaNGA will deploy 17 fiber-bundle IFUs across the Sloan 2.5m Telescope's 3 degree field-of-view, targeting a mass-selected sample with a median redshift of 0.03, typical spatial resolution of 1-2 kpc, and a per-fiber signal-to-noise ratio of 4-8 in the outskirts of target galaxies. For each galaxy in the sample, MaNGA will provide maps and measured gradients of the composition and dynamics of both stars and gas. Early results highlight MaNGA's potential to shed light on the ionization and chemical enrichment of gas in galaxies, spatial patterns in their star formation histories, and the internal makeup of stellar populations. MaNGA's unprecedented data set will not only provide powerful new insight on galaxy formation and evolution but will serve as a valuable benchmark for future high-z observations from large telescopes as well as space-based facilities.

  19. Diet of Theropithecus from 4 to 1 Ma in Kenya

    PubMed Central

    Cerling, Thure E.; Chritz, Kendra L.; Jablonski, Nina G.; Leakey, Meave G.; Manthi, Fredrick Kyalo

    2013-01-01

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0–2.5 Ma) and T. oswaldi (2.0–1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets. PMID:23733967

  20. Transmutation of MA in the high flux thermal reactor

    NASA Astrophysics Data System (ADS)

    Liu, Bin; Hu, Wenchao; Wang, Kai; Huang, Liming; Ouyang, Xiaoping; Tu, Jing; Zhu, Yangni

    2013-06-01

    We study the MA transmutation characteristics in the high flux thermal reactor, our calculation shows that different MA nuclides may have the drastically different effects on keff, Np-237, Am-241 and Am-243 decrease keff greatly, Cm-244 affects the keff slightly, but Cm-245 boosts the keff significantly. The MA nuclides actually can act as the burnable poisons in the thermal reactors. The SCALE simulation shows that after 300-day-exposure in high flux thermal reactor the disappearance rate of Np-237, Am-241 and Am-243 are 73.7%, 98.1% and 82.8% respectively. The SCALE simulation results also show that the total transmutation rate of MA nuclides by fission which include direct and indirect fission after 300-day-exposure in the high flux thermal reactor is 6.3%. The SCALE simulation indicates at least 44.2% MA nuclides transmute to plutonium isotopes by various reactions and 63% of the Pu-238 in the MOX fuel is consumed during 300-day-exposure in this reactor.

  1. Pyroxenite in the Galapagos plume source at 65 Ma

    NASA Astrophysics Data System (ADS)

    Whalen, W. T.; Gazel, E.; Vidito, C. A.; Herzberg, C. T.; Class, C.; Bizimis, M.; Alvarado-Induni, G.

    2013-12-01

    Mantle plumes originate from boundary layers below the upper mantle. Their surface expressions as hotspot tracks have been linked to voluminous outpourings of lava in the form of large igneous provinces. The Galapagos hotspot has been active since ~90 Ma and the oldest lavas of its associated submarine ridge have been dated to ~14 Ma, subducting at the Middle America Trench, off Costa Rica. The Galapagos plume head magmatic production is preserved as the Caribbean Large Igneous Province (CLIP). A series of 15-65 Ma accreted Galapagos paleo-ridges and islands/seamounts are accreted in the Pacific coast of Costa Rica and Panama. One of these accreted terranes, the Quepos block on the west coast of Costa Rica is an ancient, ~65 Ma Galapagos island. Olivine phenocrysts from Quepos picrites have elevated Ni and low Ca and Mn and Fe/Mn indicative of a dominant pyroxenite source component while CLIP samples are dominated by a peridotite source. The mantle potential temperature (max) of the plume changed from ~1650 to ~1550 C at 65 Ma. This change correlates with the first appearance of the pyroxenite component and an EMII signature (Northern Galapagos Domain) in the Galapagos plume. A relatively dense pyroxenite component may provide a mechanism for the change in Tp due to its effect on the plume's bouyancy. Alternatively, the pyroxenite component was diluted by high peridotite melt fraction during the massive production of the CLIP.

  2. Diet of Theropithecus from 4 to 1 Ma in Kenya

    NASA Astrophysics Data System (ADS)

    Cerling, Thure E.; Chritz, Kendra L.; Jablonski, Nina G.; Leakey, Meave G.; Kyalo Manthi, Fredrick

    2013-06-01

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0-2.5 Ma) and T. oswaldi (2.0-1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets.

  3. Changing the Safety and Mission Assurance (S and MA) Paradigm

    NASA Technical Reports Server (NTRS)

    Malone, Roy W.; Safie, Fayssal M.

    2010-01-01

    This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

  4. Synthesis and screening of 3-MA derivatives for autophagy inhibitors.

    PubMed

    Wu, Yanyang; Wang, Xin; Guo, Haijing; Zhang, Bo; Zhang, Xiao-Bo; Shi, Zhang-Jie; Yu, Li

    2013-04-01

    Autophagy is a conserved degradation process, which plays important pathophysiological roles. The lack of effective inhibitors of autophagy has been an obstacle in both basic research and understanding the physiological role of autophagy in disease manifestation. The most widely used inhibitor, 3-methyladenine (3-MA), is poorly soluble at room temperature and is effective only at high concentrations. In this study, we synthesized a library of small compounds by chemically modifying 3-MA and screened this library for autophagy inhibitors. Three 3-MA derivatives generated through this approach showed improved solubility and effectiveness in inhibiting autophagy. We demonstrated that chemical modification of an existing autophagy inhibitor is an effective method to generate improved autophagy inhibitors.

  5. Discharge rates in Ma'adim Vallis, Mars

    NASA Technical Reports Server (NTRS)

    Thornhill, G. D.; Rothery, D. A.; Murray, J. B.; Day, T.; Cook, A. C.; Muller, J-P.; Iliffe, J. C.

    1993-01-01

    A digital elevation model (DEM) of a small part of the Martian channel Ma'adim Vallis was produced using the Frankot and Chellappa shape-from-shading algorithm. Software developed by the Dept. of Photogrammetry and Surveying at University College London uses this technique to extract slope information from the grey levels of image pixels. This technique was applied to a Viking Orbiter image of part of Ma'adim Vallis, and measurements of the channel depth and bed-slope of a channel incised into the floor of Ma'adim Vallis were made. These results were used to calculate order of magnitude estimates for discharge rates through the channel. The maximum values calculated are three orders of magnitude less than those for N. Kasei Vallis and are similar to values cited for the Missoula floods. However, when more realistic values of the water depth are used, discharge rates comparable with those for the Mississippi River result.

  6. [The anatomical concept of Ma Wang Dui archeological artifacts].

    PubMed

    Yang, Su-Tso

    2010-01-01

    Amongst the archeological findings of Ma Wang Dui that concern the human anatomy, the first noted was a well-preserved female corpse, which demonstrated superb antiseptic techniques of the ancient Chinese. Also, 14 medical books were excavated and revealed a prototype of human visceral anatomy. The differentiation between small and large intestines was absent, and only the term of "intestine" was mentioned. The term of "triple energizers" was absent, too. However, contexts of surface anatomy were already abundant. Analyzing the terms of relative position, the anatomical position portrayed by the Ma Wang Dui medical texts is very similar to that of modern medicine.

  7. Potential reductions of street solids and phosphorus in urban watersheds from street cleaning, Cambridge, Massachusetts, 2009-11

    USGS Publications Warehouse

    Sorenson, Jason R.

    2013-01-01

    Material accumulating and washing off urban street surfaces and ultimately into stormwater drainage systems represents a substantial nonpoint source of solids, phosphorus, and other constituent loading to waterways in urban areas. Cost and lack of usable space limit the type and number of structural stormwater source controls available to municipalities and other public managers. Non-structural source controls such as street cleaning are commonly used by cities and towns for construction, maintenance and aesthetics, and may reduce contaminant loading to waterways. Effectiveness of street cleaning is highly variable and potential improvements to water quality are not fully understood. In 2009, the U.S. Geological Survey, in cooperation with the Massachusetts Department of Environmental Protection, the U.S. Environmental Protection Agency, and the city of Cambridge, Massachusetts, and initiated a study to better understand the physical and chemical nature of the organic and inorganic solid material on street surfaces, evaluate the performance of a street cleaner at removing street solids, and make use of the Source Loading and Management Model (SLAMM) to estimate potential reductions in solid and phosphorus loading to the lower Charles River from various street-cleaning technologies and frequencies. Average yield of material on streets collected between May and December 2010, was determined to be about 740 pounds per curb-mile on streets in multifamily land use and about 522 pounds per curb-mile on commercial land-use streets. At the end-of-winter in March 2011, about 2,609 and 4,788 pounds per curb-mile on average were collected from streets in multifamily and commercial land-use types, respectively. About 86 percent of the total street-solid yield from multifamily and commercial land-use streets was greater than or equal to 0.125 millimeters in diameter (or very fine sand). Observations of street-solid distribution across the entire street width indicated that as

  8. In vivo two-dimensional NMR correlation spectroscopy

    NASA Astrophysics Data System (ADS)

    Kraft, Robert A.

    1999-10-01

    The poor resolution of in-vivo one- dimensional nuclear magnetic resonance spectroscopy (NMR) has limited its clinical potential. Currently, only the large singlet methyl resonances arising from N-acetyl aspartate (NAA), choline, and creatine are quantitated in a clinical setting. Other metabolites such as myo- inositol, glutamine, glutamate, lactate, and γ- amino butyric acid (GABA) are of clinical interest but quantitation is difficult due to the overlapping resonances and limited spectral resolution. To improve the spectral resolution and distinguish between overlapping resonances, a series of two- dimensional chemical shift correlation spectroscopy experiments were developed for a 1.5 Tesla clinical imaging magnet. Two-dimensional methods are attractive for in vivo spectroscopy due to their ability to unravel overlapping resonances with the second dimension, simplifying the interpretation and quantitation of low field NMR spectra. Two-dimensional experiments acquired with mix-mode line shape negate the advantages of the second dimension. For this reason, a new experiment, REVOLT, was developed to achieve absorptive mode line shape in both dimensions. Absorptive mode experiments were compared to mixed mode experiments with respect to sensitivity, resolution, and water suppression. Detailed theoretical and experimental calculations of the optimum spin lock and radio frequency power deposition were performed. Two-dimensional spectra were acquired from human bone marrow and human brain tissue. The human brain tissue spectra clearly reveal correlations among the coupled spins of NAA, glutamine, glutamate, lactate, GABA, aspartate and myo-inositol obtained from a single experiment of 23 minutes from a volume of 59 mL. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  9. Cochlear Macromechanical Modelling

    NASA Astrophysics Data System (ADS)

    Wilson, Timothy Alan

    Contemporary research into the manifestations and origins of nonlinear, active cochlear processes often takes place in a context in which linear, passive cochlear mechanics are poorly understood and poorly communicated. The distinctions among models of one-, two-, and three-dimensional fluid motion in the cochlear scala--models popularized by (among others) Zwislocki, Ranke, and Steele, respectively --are confounded by fuzzy use of terms such as "long-wave model" or "short-wave model." Models are frequently evaluated by comparing their place responses with experimentally observed frequency responses; their global impedance parameters are sometimes chosen solely to secure fit to some local measurement. And Steele's WKB (phase-integral) approach is treated, more often than not, as just another technique for solving cochlear dynamical equations, rather than as a conceptual framework yielding significant insight into cochlear phenomena. In this thesis, I present cochlear dynamical equations for one-, two-, and three-dimensional fluid motion in a box-cochlea model, and I discuss the conditions under which such fluid motion is appropriately described as long wave, short wave, or as something in between. I describe the phase-integral approximate solution to these equations and discuss the utility of this framework for explaining cochlear phenomena. I develop generalized representations for both cochlear-partition impedance and cochlear-gain response that highlight the distinctions and similarities between the place response at a single frequency and the frequency response at a single place. The generalized representations clarify which aspects of partition impedance determine global phenomena, such as cochlear maps, and which aspects determine local features, such as magnitude -response peakiness and phase-response steepness. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.).

  10. Inclusive Production of Strange Particles at the CERN Proton-Antiproton Collider

    NASA Astrophysics Data System (ADS)

    Tan, Ching-Hua

    1994-01-01

    During the 1987 run of the CERN Proton-Antiproton Collider, at sqrt{s} = 630 GeV, the UA1 experiment collected about 2.4 times 10^6 (65 murm b^{-1}) events with a minimum bias trigger. An extensive study of the strange particle productions in this data set was performed. The measured masses of the strange particles are in very good agreement with the particle data group values and demonstrate the superb quality of the data. The production cross sections of K_sp{S}{0}, K^+/- , Lambda and |{Lambda} are measured. K_sp{S}{0 }, K^+/- production cross section measurements are in agreement with an available new NLO QCD prediction. The K_sp{S }{0} to the charged hadrons production ratio and that of Lambda + |{Lambda} to the charged hadrons as a function of multiplicity are measured. They are well explained by the quark model. We have also compared these features with those in heavy ion experiments. The strangeness suppression factor lambda is measured to be exactly the world average value. The average p_{t} of K _sp{S}{0}, K/ pi ratio and lambda are found to increase with sqrt{s}. The predictions for K/pi and lambda are made at the LHC energy 15 TeV pp collisions. The initial energy density that UA1 reached is given and the expectations at the LHC 6300 GeV/A Pb-Pb and RHIC Au-Au 200 GeV/A collisions are illustrated. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  11. Optimizing molecular electrostatic interactions: Binding affinity and specificity

    NASA Astrophysics Data System (ADS)

    Kangas, Erik

    The design of molecules that bind tightly and specifically to designated target molecules is an important goal in many fields of molecular science. While the shape of the molecule to be designed is a relatively well defined problem with an intuitive answer, determination of the distribution of electrostatic charge that it should have in order to possess high affinity and/or specificity for a target is a subtle problem involving a tradeoff between an unfavorable electrostatic desolvation penalty incurred due to the removal of solvent from the interacting surfaces of the reactants, and the generally favorable intermolecular interactions made in the bound state. In this thesis, a theoretical formalism based on a continuum electrostatic approximation is developed in which charge distributions leading to optimal affinity and/or high specificity may be obtained. Methods for obtaining these charge distributions are developed in detail and analytical solutions are obtained in several special cases (where the molecules are shaped as infinite membranes, spheres, and spheroids). Their existence and non-uniqueness are also shown, and it is proven that the resulting optimized electrostatic binding free energies are favorable (negative) in many cases of physical interest. Affinity and specificity optimization is then applied to the chorismate mutase family of enzymes, including the catalytic antibody 1F7. It is shown that affinity optimization can be used to suggest better molecular inhibitors and that specificity optimization can be used to help elucidate molecular function and possibly aid in the creation of improved haptens. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  12. Transition to Turbulence in Rectangular Channels with Eddy Promoters: Implications to Heat Transfer Augmentation.

    NASA Astrophysics Data System (ADS)

    Kapat, Jayanta Sankar

    1991-02-01

    The work deals with experimental investigation of laminar-to-turbulent transition in a rectangular channel of aspect ratio 0.116 in the presence of periodic eddy promoters. The study is motivated by the role of transition in heat transfer enhancement schemes that employ flow destabilization strategies: specifically, for this type of augmentation systems, the most efficient performance (minimum pumping power per unit of heat removal) occurs in the transition region. Seven different geometries are tested: plain channel and six different arrangements of cylindrical eddy promoters. Placement of the eddy promoters in the channel, depending on the pattern, can significantly reduce Reynolds number values at transition: the critical Reynolds number (based on the average velocity and the channel height) ranges from 1500 (for a plain channel) to about 400 (for the most unstable configuration deployed). For all the cases tested, demarcation of transition can be correlated with the following expression, Re_tau = sqrt{ {| tau_{w,avoverrho }}} {H/2overnu} = 40 ~ 60,where | tau_{w,av} is the spatially averaged value of mean wall shear stress and H is the channel height. The above correlation extends to other geometries. The approximate invariance of Re_ tau at transition allows evaluation of heat transfer at transition point by using only the critical Reynolds number (Recrit). Based on Colburn analogy, Nu at transition for fluids with Pr > 0.6 can be calculated as Nu~ {10,000over Recrit} Pr^{1/3}.(Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.).

  13. Adaptive Mesh Euler Equation Computation of Vortex Breakdown in Delta Wing Flow.

    NASA Astrophysics Data System (ADS)

    Modiano, David Laurence

    A solution method for the three-dimensional Euler equations is formulated and implemented. The solver uses an unstructured mesh of tetrahedral cells and performs adaptive refinement by mesh-point embedding to increase mesh resolution in regions of interesting flow features. The fourth-difference artificial dissipation is increased to a higher order of accuracy using the method of Holmes and Connell. A new method of temporal integration is developed to accelerate the explicit computation of unsteady flows. The solver is applied to the solution of the flow around a sharp edged delta wing, with emphasis on the behavior of the leading edge vortex above the leeside of the wing at high angle of attack, under which conditions the vortex suffers from vortex breakdown. Large deviations in entropy, which indicate vortical regions of the flow, specify the region in which adaptation is performed. Adaptive flow calculations are performed at ten different angles of attack, at seven of which vortex breakdown occurs. The aerodynamic normal force coefficients show excellent agreement with wind tunnel data measured by Jarrah, which demonstrates the importance of adaptation in obtaining an accurate solution. The pitching moment coefficient and the location of vortex breakdown are compared with experimental data measured by Hummel and Srinivasan, with which fairly good agreement is seen in cases in which the location of breakdown is over the wing. A series of unsteady calculations involving a pitching delta wing were performed. The use of the acceleration technique is validated. A hysteresis in the normal force is observed, as in experiments, and a lag in the breakdown position is demonstrated. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  14. The physical response of soft musculoskeletal tissues to short-pulsed laser irradiation

    NASA Astrophysics Data System (ADS)

    Dark, Marta Lyselle

    of the interaction of short laser pulses with cartilage tissue, and measured significant physical properties of knee meniscus with a minimally invasive laser technique. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  15. A SANS study of the interfacial curvatures and the phase behavior in bicontinuous microemulsions

    NASA Astrophysics Data System (ADS)

    Choi, Sung-Min

    A microemulsion is a three-component system in which oil and water are solubilized via an interfacial surfactant monolayer. Depending on the composition and various external conditions, it exhibits a wide variety of phases with corresponding mesoscopic scale interfacial structures. For scientific as well as industrial purposes, knowledge of the relation between the interfacial structure and the phase behavior is crucial but its quantitative measure is lacking. To identify the relation in a quantitative way, the natural parameters to be measured are the interfacial curvatures: Gaussian, mean, and square mean curvatures. A new small-angle neutron scattering (SANS) data analysis method to extract the interfacial curvatures was developed and applied to various microemulsions. The method involves the use of a clipped random wave model with an inverse 8th order polynomial spectral function. The spectral density function contains three basic length scales: the inter- domain distance, the coherence length, and the surface roughness parameter. These three length scales are essential to describe mesoscopic scale interfaces. A series of SANS experiments were performed at various phase points of isometric and non-isometric microemulsions. Using the developed model, the three interfacial curvatures at each phase point were determined for the first time in a practical way. In isometric bicontinuous microemulsions, the Gaussian curvature is negative and has a parabolic dependence on the surfactant volume fraction. In non-isometric systems, based on the measured interfacial curvatures, a characteristic structural transformation was identified. As the water and oil volume ratio moves away from unity, the bicontinuous structure transforms to a spherical structure through an intermediate cylindrical structure. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  16. Laminar flame propagation in a stratified charge

    NASA Astrophysics Data System (ADS)

    Ra, Youngchul

    The propagation of laminar flame from a rich or stoichiometric mixture to a lean mixture in a stratified methane-air charge was investigated experimentally and numerically. Emphasis was on the understanding of the flame behavior in the transition region; in particular, on the mechanism of burning velocity enhancement in this region. In the experimental setup, mixtures of two different equivalence ratios were separated by a soap bubble in a spherical constant volume combustion vessel. The richer mixture inside the bubble was ignited by a focused laser beam. The flame development was observed by Schlieren technique and flame speeds were measured by heat release analysis of the pressure data. An one-dimensional, time- dependant numerical simulation of the flame propagation in a charge with step-stratification was used to interpret the experimental results. Both the experimental and numerical studies showed that the instantaneous flame speed depended on the previous flame history. Thus a `strong' (with mixture equivalence ratio close to stoichiometric) flame can sustain propagation into finite regions of substantially lean equivalence ratio. Both thermal and chemical effects were crucial for explaining the mechanism of the flame speed enhancement in the transition period. Because of the presence of this `back- support' effect, the usual concept of specifying the burning velocity as a function of the end gas state is inadequate for a stratified charge. A simple correlation for instantaneous flame velocity based on the local burned gas temperature is developed. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

  17. Polymeric photonic crystals

    NASA Astrophysics Data System (ADS)

    Fink, Yoel

    Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  18. Dynamic reconstruction and multivariable control for force-actuated, thin facesheet adaptive optics

    NASA Astrophysics Data System (ADS)

    Grocott, Simon C. O.

    1997-10-01

    The Multiple Mirror Telescope (MMT) under development at the University of Arizona takes a new approach in adaptive optics placing a large (0.65 m) force-actuated, thin facesheet deformable mirror at the secondary of an astronomical telescope, thus reducing the effects of emissivity which are important in IR astronomy. However, the large size of the mirror and low stiffness actuators used drive the natural frequencies of the mirror down into the bandwidth of the atmospheric distortion. Conventional adaptive optics takes a quasi-static approach to controlling the deformable mirror. However, flexibility within the control bandwidth calls for a new approach to adaptive optics. Dynamic influence functions are used to characterize the influence of each actuator on the surface of the deformable mirror. A linearized model of atmospheric distortion is combined with dynamic influence functions to produce a dynamic reconstructor. This dynamic reconstructor is recognized as an optimal control problem. Solving the optimal control problem for a system with hundreds of actuators and sensors is formidable. Exploiting the circularly symmetric geometry of the mirror, and a suitable model of atmospheric distortion, the control problem is divided into a number of smaller decoupled control problems using circulant matrix theory. A hierarchic control scheme which seeks to emulate the quasi-static control approach that is generally used in adaptive optics is compared to the proposed dynamic reconstruction technique. Although dynamic reconstruction requires somewhat more computational power to implement, it achieves better performance with less power usage, and is less sensitive than the hierarchic technique. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690).

  19. X-ray spectroscopic and timing studies of galactic black hole binaries

    NASA Astrophysics Data System (ADS)

    Miller, Jon Matthew

    In rare cases, optical observations of Galactic binary star systems which are bright in the X-ray portion of the electromagnetic spectrum dynamically constrain the mass of one component to be well above theoretical limits for a neutron star. These systems—and systems with similar X-ray properties—are classified as black hole binaries. In this thesis, I report on observations of black hole binaries made with satellite observatories in the X-ray band. The region closest to the black hole is revealed in X-rays due to the viscous heating of matter that is accreted from the companion star. X-ray observations of these systems may therefore reveal General Relativistic effects. A fundamental and testable prediction of General Relativity is that matter may orbit more closely around black holes with significant angular momentum. I have investigated the possibility of black hole “spin” and the geometry of accretion flows in these systems using X-ray continuum spectroscopy, fast variability studies, and the shape of iron fluorescent emission lines in this band. I present evidence for black hole spin in XTE J1550-564, XTE J1650- 500, and XTE J1748-248. Spin is not required by high- resolution spectral analysis of the archetypical Galactic black hole—Cygnus X-1—but a thermal accretion disk plus hot corona geometry is confirmed. Studies of XTE J1118+480 and GRS 1758-258 at low X-ray luminosity reveal that models for radiatively-inefficient accretion do not satisfactorily describe the geometry in these systems. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)/

  20. Faint gamma-ray bursts and other high-energy transients detected with BATSE

    NASA Astrophysics Data System (ADS)

    Kommers, Jefferson Michael

    1999-03-01

    The Burst and Transient Source Experiment (BATSE) onboard the Compton Gamma Ray Observatory detects gamma-ray bursts (GRBs) and other high-energy astronomical transients using a real-time burst detection system running onboard the spacecraft. This thesis describes a search of the archival BATSE data for GRBs, emission from soft gamma-ray repeaters (SGRs), bursts and flares from X-ray binaries, and other transients that were not detected by the onboard system. The search covers six years of the mission, from 1992 December 9.0 to 1997 December 17.0. The search reveals 873 GRB candidates that did not activate the onboard burst detection because they were too faint, because they occurred while the onboard system was disabled for technical reasons, or because their time profile artificially raised the onboard detection threshold. The catalog of these bursts increases the number of GRBs detected with BATSE by 48% during the time period of the search. The intensity distribution of the GRBs detected with the search reaches peak fluxes that are a factor of ~2 lower than could be studied previously. The value of the statistic (in Euclidean space) for these bursts, 0.177 +/- 0.006, is the lowest so far obtained for a global sample of GRBs. The differential peak flux distribution is consistent with cosmological models in which the co-moving GRB rate approximately traces the star-formation history of the Universe. These results suggest that more sensitive detectors are likely to discover relatively few GRBs (of the kind currently known) that are fainter than the BATSE detection threshold. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  1. A Initio Study of the SILICON(111)-(7 by 7) Surface Reconstruction: a Challenge for Massively Parallel Computation

    NASA Astrophysics Data System (ADS)

    Brommer, Karl Daniel

    This thesis presents the first ab initio calculation of the Si(111)-(7 x 7) surface reconstruction, perhaps the most complex and widely studied surface of a solid. The large number of atoms in the unit cell has up to now defied any complete and realistic treatment of its properties. In this thesis, we exploit the power of massively parallel computation to investigate the surface reconstruction with a supercell geometry containing 700 effective atoms. These calculations predict the fully relaxed atomic geometry of this system; allow construction of theoretical STM images as a function of bias voltages; and predict the energy difference between the (7 x 7) and (2 x 1) reconstructions. The diversity of dangling bond sites on the (7 x 7) surface provides an optimal system for investigating chemical reactivity. A detailed study of the electronic surface states is presented, showing that the interpretation of the surface chemical reactivity in terms of newly developed theories of local softness is consistent with chemisorption experiments. We conclude with predictions of results for surface reactions involving a large variety of atoms and molecules. The method of computing electronic structure on a massively parallel computer is fully described, including a discussion of how the calculations would be improved through implementation on a more modern parallel computer. The results demonstrate that the state of the art in ab initio quantum-mechanical computation of electronic structure has been raised to a new echelon as the study of systems involving thousands of atoms is now possible. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  2. CFT correlation functions from AdS/CFT correspondence

    NASA Astrophysics Data System (ADS)

    Matusis, Alec

    In this thesis we discuss correlation functions of N = 4, d = 4 Super-Yang-Mills theory in the strong coupling regime. Namely, the recent conjecture of the equivalence of the string theory in AdS5 x S5 background to the N = 4, d = 4 SYM theory with SU( N) gauge group allows to find correlation functions of the CFT in the limit of large t'Hooft coupling and at large N by evaluating relatively simple tree-level supergravity amplitudes. We discuss the basic ideas of the AdS supergravity computations, and establish the techniques for evaluating tree-level AdS supergravity scattering amplitudes with fixed rates of fall-offs of the fields as they approach AdS boundary. We translate these supergravity results into field theory language and learn several interesting things. First, at the level of the two-point correlation functions we learn about the necessity for the introduction of a cut-off in seemingly convergent AdS supergravity computations. Next, we find a non-renormalization property of certain 3-point functions. Finally, we find an explicit expression for certain 4-point functions, which deviate from free-field approximation in perturbation theory, thus providing some new non- perturbative information about SYM. We study various limits of these 4-point functions, with intention to give them an OPE interpretation. We find logarithmic singularities in all limits, and discuss their compatibility with existence of an OPE at strong coupling. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  3. Optical Coherence Tomography

    NASA Astrophysics Data System (ADS)

    Huang, David

    . (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.).

  4. Vortex Dynamics in Anisotropic Superconductors

    NASA Astrophysics Data System (ADS)

    Steel, David Gordon

    Measurements of the ac screening response and resistance of superconducting Bi_2Sr _2CaCu_2O _8 (BSCCO) crystals have been used to probe the dynamics of the magnetic flux lines within the mixed state as a function of frequency, temperature, and applied dc field. For the particular range of temperature and magnetic field in which measurements were made, the systematic behavior of the observed dissipation peak in the screening response is consistent with electromagnetic skin size effects rather than a phase transition. According to microscopic theories of the interaction between the flux lines and a driving ac field, such a skin size effect is expected for the case when the vortex motion is diffusive in nature. However, diffusive motion is inconsistent with simple activation models that use a single value for the pinning energy (derived from direct measurement of the dc resistance). This contradiction suggests a distribution of pinning energies within the sample. Interlayer vortex decoupling has been directly observed as a function of temperature and applied magnetic field using electronic transport perpendicular to the layers in synthetic amorphous MoGe/Ge multilayer samples. Perpendicular transport has been shown to be a far more sensitive measure of the phase coupling between layers than in-plane properties. Below the decoupling temperature T_{D} the resistivity anisotropy collapses and striking nonlinearities appear in the perpendicular current-voltage behavior, which are not observed in parallel transport. A crossover in behavior is also observed at a field H _{x}, in accordance with theory. The data suggest the presence of a phase transition into a state with finite in-plane resistivity. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  5. Geometric control of quantum mechanical and nonlinear classical systems

    NASA Astrophysics Data System (ADS)

    Nelson, Richard Joseph

    1999-10-01

    Geometric control refers to the judicious use of the non- commuting nature of inputs and natural dynamics as the basis for control. The last few decades in control system theory have seen the application of differential geometry in proving several important properties of systems, including controllability and observability. Until recently, however, the results of this mathematical geometry have rarely been used as the basis for designing and implementing an actual controller. This thesis demonstrates the application of a judicious selection of inputs, so that if the system is proven to be controllable using geometric methods, one can design input sequences using the same geometry. A demonstration of this method is shown in simulating the attitude control of a satellite: a highly non-linear, non- holonomic control problem. Although not a practical method for large re-orientations of a typical satellite, the approach can be applied to other nonlinear systems. The method is also applied to the closed-loop performance of a quantum mechanical system to demonstrate the feasibility of coherent quantum feedback-something impossible using a conventional controller. Finally, the method is applied in the open-loop control of a quantum mechanical system: in this case, the creation of Greenberger-Horne-Zeilinger correlations among the nuclei of an ensemble of alanine molecules in a nuclear magnetic resonance spectrometer. In each case, the data demonstrate the usefulness of a geometric approach to control. In addition to demonstrations of geometric control in practice, the quantum mechanical experiments also demonstrate for the first time peculiar quantum correlations, including GHZ correlations, that have no classical analog. The quantum experiments further establish nuclear magnetic resonance as a viable and accessible testbed of quantum predictions and processes. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax

  6. A Coupled Eulerian/lagrangian Method for the Solution of Three-Dimensional Vortical Flows

    NASA Astrophysics Data System (ADS)

    Felici, Helene Marie

    1992-01-01

    A coupled Eulerian/Lagrangian method is presented for the reduction of numerical diffusion observed in solutions of three-dimensional rotational flows using standard Eulerian finite-volume time-marching procedures. A Lagrangian particle tracking method using particle markers is added to the Eulerian time-marching procedure and provides a correction of the Eulerian solution. In turn, the Eulerian solution is used to integrate the Lagrangian state-vector along the particles trajectories. The Lagrangian correction technique does not require any a-priori information on the structure or position of the vortical regions. While the Eulerian solution ensures the conservation of mass and sets the pressure field, the particle markers, used as 'accuracy boosters', take advantage of the accurate convection description of the Lagrangian solution and enhance the vorticity and entropy capturing capabilities of standard Eulerian finite-volume methods. The combined solution procedure is tested in several applications. The convection of a Lamb vortex in a straight channel is used as an unsteady compressible flow preservation test case. The other test cases concern steady incompressible flow calculations and include the preservation of a turbulent inlet velocity profile, the swirling flow in a pipe, the constant stagnation pressure flow and secondary flow calculations in bends. The last application deals with the external flow past a wing with emphasis on the trailing vortex solution. The improvement due to the addition of the Lagrangian correction technique is measured by comparison with analytical solutions when available or with Eulerian solutions on finer grids. The use of the combined Eulerian/Lagrangian scheme results in substantially lower grid resolution requirements than the standard Eulerian scheme for a given solution accuracy. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  7. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., as determined by CMS, for individuals with mental or cognitive conditions, including mental illness... disenrollment, including conditions on future enrollment, within 20 working days. During the review, CMS will... 42 Public Health 3 2014-10-01 2014-10-01 false Disenrollment by the MA organization....

  8. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., as determined by CMS, for individuals with mental or cognitive conditions, including mental illness... disenrollment, including conditions on future enrollment, within 20 working days. During the review, CMS will... 42 Public Health 3 2011-10-01 2011-10-01 false Disenrollment by the MA organization....

  9. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., as determined by CMS, for individuals with mental or cognitive conditions, including mental illness... disenrollment, including conditions on future enrollment, within 20 working days. During the review, CMS will... 42 Public Health 3 2012-10-01 2012-10-01 false Disenrollment by the MA organization....

  10. 78 FR 15292 - Drawbridge Operation Regulations; West Bay, Osterville, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ....regulations.gov . Type the docket number in the ``SEARCH'' box and click ``SEARCH.'' Click on Open Docket... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; West Bay, Osterville, MA...

  11. Thesis Writing Challenges for Non-Native MA Students

    ERIC Educational Resources Information Center

    Sadeghi, Karim; Shirzad Khajepasha, Arash

    2015-01-01

    Writing in a second (L2)/foreign language is generally a challenging activity, and writing an MA thesis, as an example of academic enterprise, can be daunting when done in a language in which the writer is not fully competent. The challenge such a genre of writing poses for L2 writers has not been properly addressed. To fill in the gap in this…

  12. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... prohibition shall not apply to MA plan names in effect on July 31, 2000. (n) Display the names and/or logos of... names, and/or logos are related to the member selection of specific provider organizations (for example, physicians, hospitals). Other marketing materials (as defined in § 422.2260) that include names and/or...

  13. 77 FR 1503 - Massasoit National Wildlife Refuge, Plymouth, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... Fish and Wildlife Service Massasoit National Wildlife Refuge, Plymouth, MA AGENCY: Fish and Wildlife... assessment; request for comments. SUMMARY: We, the U.S. Fish and Wildlife Service (Service), intend to... Wildlife Refuge (the refuge, NWR) in Plymouth, Massachusetts. We provide this notice in compliance with...

  14. The Launch of the MA-6, Friendship 7

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The launch of the MA-6, Friendship 7, on February 20, 1962. Boosted by the Mercury-Atlas vehicle, a modified Atlas Intercontinental Ballistic Missile (ICBM), Friendship 7 was the first U.S. marned orbital flight and carried Astronaut John H. Glenn into orbit. Astronaut Glenn became the first American to orbit the Earth.

  15. NoMaDS: The Northern Massive Dim Stars Survey

    NASA Astrophysics Data System (ADS)

    Pellerin, Anne; Maíz Apellániz, J.; Simón-Díaz, S.; Barbá, R. H.

    2012-01-01

    We present the Northern Massive Dim Stars Survey (NoMaDS), a high-resolution spectroscopic campaign at the 9.2m Hobby-Eberly Telescope. The project aims at building the most complete and homogeneous spectroscopic database of hot, massive Galactic OB stars. NoMaDS is part of an international collaboration that combines observations from Chilean, Spanish, and Texan facilities. The contribution of NoMaDS is to complement the other sister surveys by providing high signal-to-noise echelle spectra (R=30000) of Galactic OB stars that are too faint for smaller ground-based telescopes. NoMaDS will provide a sample of about 200 stars, many of which have never been observed before at such a high resolution. Here we present the details of the survey, as well as echelle spectra obtained with the High Resolution Spectrograph since May 2011. This includes spectra of standard OB stars, Wolf-Rayet stars, binary systems, and oblique magnetic rotators. This survey will provide unprecedented spectroscopic database for a more accurate spectral classification, a quantitative analysis using atmosphere modeling, the detection and follow up of the orbits of massive spectroscopic binaries as well as the study of diffuse interstellar bands.

  16. MaRGEE: Move and Rotate Google Earth Elements

    NASA Astrophysics Data System (ADS)

    Dordevic, Mladen M.; Whitmeyer, Steven J.

    2015-12-01

    Google Earth is recognized as a highly effective visualization tool for geospatial information. However, there remain serious limitations that have hindered its acceptance as a tool for research and education in the geosciences. One significant limitation is the inability to translate or rotate geometrical elements on the Google Earth virtual globe. Here we present a new JavaScript web application to "Move and Rotate Google Earth Elements" (MaRGEE). MaRGEE includes tools to simplify, translate, and rotate elements, add intermediate steps to a transposition, and batch process multiple transpositions. The transposition algorithm uses spherical geometry calculations, such as the haversine formula, to accurately reposition groups of points, paths, and polygons on the Google Earth globe without distortion. Due to the imminent deprecation of the Google Earth API and browser plugin, MaRGEE uses a Google Maps interface to facilitate and illustrate the transpositions. However, the inherent spatial distortions that result from the Google Maps Web Mercator projection are not apparent once the transposed elements are saved as a KML file and opened in Google Earth. Potential applications of the MaRGEE toolkit include tectonic reconstructions, the movements of glaciers or thrust sheets, and time-based animations of other large- and small-scale geologic processes.

  17. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313. This form, which may be obtained from the American War Risk Agency or MARAD, shall be filed...

  18. 76 FR 14804 - Drawbridge Operation Regulations; Bass River, Beverly, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Bass River, Beverly, MA AGENCY... the Hall Whitaker Bridge at mile 0.6 across the Bass River ] at Beverly, Massachusetts. The deviation.... SUPPLEMENTARY INFORMATION: The Hall Whitaker Bridge, across the Bass River at Beverly, Massachusetts, has...

  19. 76 FR 64009 - Drawbridge Operation Regulation; Apponagansett River, Dartmouth, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ..., Dartmouth, MA AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard has changed the... River, mile 1.0, at Dartmouth, Massachusetts. The owner of the bridge requested relief from crewing the... Apponagansett River, mile 1.0, at Dartmouth, Massachusetts, has a vertical clearance in the closed position of...

  20. 76 FR 37041 - Drawbridge Operation Regulation; Apponagansett River, Dartmouth, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-24

    ..., Dartmouth, MA AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard... across the Apponagansett River, mile 1.0, at Dartmouth, Massachusetts. The owner of the bridge has... identified by docket number USCG- 2011-0335 using any one of the following methods: (1) Federal...

  1. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... coordinated care plan. A coordinated care plan is a plan that includes a network of providers that are under... network is approved by CMS to ensure that all applicable requirements are met, including access and...) of this section. (D) Other network plans (except PFFS plans). (iv) A specialized MA plan for...

  2. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) A coordinated care plan. A coordinated care plan is a plan that includes a network of providers that.... (i) The network is approved by CMS to ensure that all applicable requirements are met, including... paragraph (a)(1)(v) of this section. (D) Other network plans (except PFFS plans). (iv) A specialized MA...

  3. 42 CFR 422.4 - Types of MA plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) A coordinated care plan. A coordinated care plan is a plan that includes a network of providers that.... (i) The network is approved by CMS to ensure that all applicable requirements are met, including... paragraph (a)(1)(v) of this section. (D) Other network plans (except PFFS plans). (iv) A specialized MA...

  4. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... available in the network. (o) Engage in any other marketing activity prohibited by CMS in its marketing... 42 Public Health 3 2013-10-01 2013-10-01 false Standards for MA organization marketing. 422.2268... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Medicare Advantage...

  5. 42 CFR 422.2268 - Standards for MA organization marketing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... available in the network. (o) Engage in any other marketing activity prohibited by CMS in its marketing... 42 Public Health 3 2014-10-01 2014-10-01 false Standards for MA organization marketing. 422.2268... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Medicare Advantage...

  6. 42 CFR 422.74 - Disenrollment by the MA organization.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... fraudulent information on his or her election form or permits abuse of his or her enrollment card as... and developmental disabilities. In addition, the MA organization must inform the individual of the..., unless otherwise determined by CMS. (3) Individual commits fraud or permits abuse of enrollment...

  7. BioMaPS: A Roadmap for Success

    ERIC Educational Resources Information Center

    McCarthy, Maeve L.; Fister, K. Renee

    2010-01-01

    The manuscript outlines the impact that our National Science Foundation Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences program, BioMaPS, has had on the students and faculty at Murray State University. This interdisciplinary program teams mathematics and biology undergraduate students with mathematics and…

  8. 75 FR 65567 - Drawbridge Operation Regulations; Mystic River, Charlestown, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Mystic River, Charlestown, MA AGENCY... Coast Guard District, has issued a temporary deviation from the regulation governing the operation of.... Wright, Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The...

  9. 42 CFR 422.306 - Annual MA capitation rates.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Annual MA capitation rates. 422.306 Section 422.306 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Payments to Medicare Advantage Organizations §...

  10. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Eligibility, Election, and Enrollment §...

  11. 42 CFR 422.64 - Information about the MA program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Information about the MA program. 422.64 Section 422.64 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Eligibility, Election, and Enrollment §...

  12. 46 CFR 7.15 - Massachusetts Bay, MA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 7.15 Massachusetts Bay, MA. A line drawn from latitude 42°37.9′ N. longitude 70°31.2′ W. (Cape Ann Lighted Whistle Buoy “2”) to latitude 42°22.7′ N. longitude 70°47.0′ W. (Boston Lighted Horn Buoy...

  13. Two remarks about Mañé's conjecture

    NASA Astrophysics Data System (ADS)

    Massart, D.

    2010-12-01

    We consider Mañé's conjectures and prove that the one he made in [1] is stronger than the one he made in [2]. Then we prove that the most straightforward approach to prove the strong conjecture doesn't work in the C 4 topology.

  14. Organisational Learning through International M&A Integration Strategies

    ERIC Educational Resources Information Center

    Holland, Wayne; Salama, Alzira

    2010-01-01

    Purpose: The purpose of this research paper is to explore the learning process associated with international mergers and acquisitions (M&A) integration strategies. Design/methodology/approach: The paper employs a comparative case study methodology, utilising qualitative data through in-depth interviews with top management responsible for…

  15. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313. This form, which may be obtained from the American War Risk Agency or MARAD, shall be filed...

  16. 46 CFR 308.533 - Closing report, Form MA-313.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.533 Closing report, Form MA-313. This form, which may be obtained from the American War Risk Agency or MARAD, shall be filed...

  17. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan,...

  18. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan,...

  19. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... and both MA local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a... terminated the MA organization's contract for the plan or discontinued the plan in the area in which the... discontinued in the area in which the individual resides, he or she may elect another MA plan; and (iii)...

  20. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... make is not limited (except as provided for in paragraph (d) of this section for MA MSA plans). Subject... by CMS, is not limited (except as provided for in paragraph (d) of this section for MA MSA plans) in... that begins on the effective date of enrollment in the MA plan. (d) Special rules for MA MSA...

  1. 42 CFR 422.104 - Special rules on supplemental benefits for MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules on supplemental benefits for MA MSA... Beneficiary Protections § 422.104 Special rules on supplemental benefits for MA MSA plans. (a) An MA organization offering an MA MSA plan may not provide supplemental benefits that cover expenses that...

  2. Component geochronology in the polyphase ca. 3920 Ma Acasta Gneiss

    USGS Publications Warehouse

    Mojzsis, Stephen J.; Cates, Nicole L.; Caro, Guillaume; Trail, Dustin; Abramov, Oleg; Guitreau, Martin; Blichert-Toft, Janne; Hopkins, Michelle D.; Bleeker, Wouter

    2014-01-01

    The oldest compiled U–Pb zircon ages for the Acasta Gneiss Complex in the Northwest Territories of Canada span about 4050–3850 Ma; yet older ca. 4200 Ma xenocrystic U–Pb zircon ages have also been reported for this terrane. The AGC expresses at least 25 km2 of outcrop exposure, but only a small subset of this has been documented in the detail required to investigate a complex history and resolve disputes over emplacement ages. To better understand this history, we combined new ion microprobe235,238U–207,206Pb zircon geochronology with whole-rock and zircon rare earth element compositions ([REE]zirc), Ti-in-zircon thermometry (Tixln) and 147Sm–143Nd geochronology for an individual subdivided ∼60 cm2 slab of Acasta banded gneiss comprising five separate lithologic components. Results were compared to other variably deformed granitoid-gneisses and plagioclase-hornblende rocks from elsewhere in the AGC. We show that different gneissic components carry distinct [Th/U]zirc vs. Tixln and [REE]zirc signatures correlative with different zircon U–Pb age populations and WR compositions, but not with 147Sm–143Nd isotope systematics. Modeled  [REE] from lattice-strain theory reconciles only the ca. 3920 Ma zircons with the oldest component that also preserves strong positive Eu∗ anomalies. Magmas which gave rise to the somewhat older (inherited) ca. 4020 Ma AGC zircon age population formed at ∼IW (iron–wüstite) to Ma emplacement age for the AGC is contemporaneous with bombardment of the inner solar system. Analytical bombardment simulations show that crustal re-working from the impact epoch potentially affected the precursors to the Acasta gneisses.

  3. Component geochronology in the polyphase ca. 3920 Ma Acasta Gneiss

    NASA Astrophysics Data System (ADS)

    Mojzsis, Stephen J.; Cates, Nicole L.; Caro, Guillaume; Trail, Dustin; Abramov, Oleg; Guitreau, Martin; Blichert-Toft, Janne; Hopkins, Michelle D.; Bleeker, Wouter

    2014-05-01

    The oldest compiled U-Pb zircon ages for the Acasta Gneiss Complex in the Northwest Territories of Canada span about 4050-3850 Ma; yet older ca. 4200 Ma xenocrystic U-Pb zircon ages have also been reported for this terrane. The AGC expresses at least 25 km2 of outcrop exposure, but only a small subset of this has been documented in the detail required to investigate a complex history and resolve disputes over emplacement ages. To better understand this history, we combined new ion microprobe 235,238U-207,206Pb zircon geochronology with whole-rock and zircon rare earth element compositions ([REE]zirc), Ti-in-zircon thermometry (Tixln) and 147Sm-143Nd geochronology for an individual subdivided ˜60 cm2 slab of Acasta banded gneiss comprising five separate lithologic components. Results were compared to other variably deformed granitoid-gneisses and plagioclase-hornblende rocks from elsewhere in the AGC. We show that different gneissic components carry distinct [Th/U]zirc vs. Tixln and [REE]zirc signatures correlative with different zircon U-Pb age populations and WR compositions, but not with 147Sm-143Nd isotope systematics. Modeled DWRzircon [REE] from lattice-strain theory reconciles only the ca. 3920 Ma zircons with the oldest component that also preserves strong positive Eu∗ anomalies. Magmas which gave rise to the somewhat older (inherited) ca. 4020 Ma AGC zircon age population formed at ˜IW (iron-wüstite) to Ma emplacement age for the AGC is contemporaneous with bombardment of the inner solar system. Analytical bombardment simulations show that crustal re-working from the impact epoch potentially affected the precursors to the Acasta gneisses.

  4. Cell-laden photocrosslinked GelMA-DexMA copolymer hydrogels with tunable mechanical properties for tissue engineering.

    PubMed

    Wang, Hang; Zhou, Lei; Liao, Jingwen; Tan, Ying; Ouyang, Kongyou; Ning, Chenyun; Ni, Guoxin; Tan, Guoxin

    2014-09-01

    To effectively repair or replace damaged tissues, it is necessary to design three dimensional (3D) extracellular matrix (ECM) mimicking scaffolds with tunable biomechanical properties close to the desired tissue application. In the present work, gelatin methacrylate (GelMA) and dextran glycidyl methacrylate (DexMA) with tunable mechanical and biological properties were utilized to prepared novel bicomponent polymeric hydrogels by cross-linking polymerization using photoinitiation. We controlled the degree of substitution (DS) of glycidyl methacrylate in DexMA so that they could obtain relevant mechanical properties. The results indicated that copolymer hydrogels demonstrated a lower swelling ratio and higher compressive modulus as compared to the GelMA. Moreover, all of the hydrogels exhibited a honeycomb-like architecture, the pore sizes decreased as DS increased, and NIH-3T3 fibroblasts encapsulated in these hydrogels all exhibited excellent viability. These characteristics suggest a class of photocrosslinkable, tunable mechanically copolymer hydrogels that may find potential application in tissue engineering and regenerative medicine applications.

  5. Shuttle Astronauts Visit NASA's X-Ray Observatory Operations Control Center in Cambridge to Coordinate Plans for Launch

    NASA Astrophysics Data System (ADS)

    1998-06-01

    CAMBRIDGE, MASS.-- June 25, 1998 Eileen Collins, the first U.S. woman commanderof a Space Shuttle mission and her fellow astronauts for NASA s STS-93 mission toured the Operations Control Center (OCC) for the Advanced X-ray Astrophysics Facility (AXAF) today. AXAF is scheduled for launch on January 26, 1999 aboard the Space Shuttle Columbia. They met with the staff of the OCC and discussed how the status of the observatory will be monitored while in the shuttle bay and during deployment. "We are honored to have this historic shuttle crew visit us and familiarize themselves with the OCC," said Harvey Tananbaum, director of the AXAF Science Center, which operates the OCC for the Smithsonian Astrophysical Observatory through a contract with NASA's Marshall Space Flight Center. "It is appropriate that a pathbreaking shuttle mission will deploy the premier X-ray observatory of this century." AXAF is the third of NASA s Great Observatories along with the Hubble Space Telescope and the Compton Gamma Ray Observatory. It will observe in greater detail than ever before the hot, violent regions of the universe that cannot be seen with optical telescopes. Exploding stars, black holes and vast clouds of gas in galaxy clusters are among the fascinating objects that AXAF is designed to study. The satellite is currently in the final stages of testing at TRW Space and Electronics Group,the prime contractor, in Redondo Beach, California. In late August it will be flown aboard a specially-outfitted Air Force C-5 aircraft to Kennedy Space Center in Florida where it will be integrated with a Boeing booster and then installed in the Shuttle bay. The shuttle crew that will take AXAF into space includes Collins (Col., USAF), Jeffrey Ashby (Cmdr., USN), pilot; Steven Hawley, Ph.D., mission specialist; Catherine Cady Coleman, Ph.D. (Major, USAF), mission specialist; and Michel Tognini (Col., French Air Force), mission specialist. While visiting the OCC the crew learned how critical data

  6. Cosmogenic Noble Gases and Their Production Rates in Eucrites, Diogenites, and Howardites: Common Asteroid Break-up Events 38 Ma, 21 Ma, and 6 MA Ago

    NASA Astrophysics Data System (ADS)

    Eugster, O.; Michel, Th.

    1993-07-01

    It is likely that the eucrites and their associates, the howardites and diogenites, sample the surface and shallow interior of a single parent body, possibly 4 Vesta (cf. [1] and [2]). A break-up event that reaches deep enough may, thus, eject asteroidal fragments representing meteorites from all three classes. In this work we present a comprehensive investigation of the exposure age clusters for howardites, eucrites, and diogenites (HEDs). Cosmic-ray exposure ages critically depend on the production rates for cosmic-ray produced nuclei. For eucrites shielding independent production rates for ^21Ne and ^38Ar have been determined previously [3,4]. We now present production rates of ^3He, ^21Ne, ^33Ar, ^78Kr, ^83Kr, and ^126Xe for eucrites, howardites, and diogenites as a function of shielding, where appropriate, and of target element abundances as derived on the basis of ^81Kr-Kr ages. E.g., for ^21Ne we obtain: P(sub)21 (EUC) = 8.43 P^1(sub)21 [16.1 (^22Ne/^21Ne)(sub)c - 10.3]^-1, P(sub)21 (HOW) = 6.16 P^1(sub)21 [18.1 (^22Ne/^21Ne)(sub)c - 14.1]^-1, P(sub)21 (DIO) = 4.81 P^1(sub)21 [25.7 (^22Ne/^21Ne)(sub)c - 23.7]^-1, where P^1(sub)21 = 1.63 [Mg] + 0.6 [Al] + 0.32 [Si] + 0.22 [S] + 0.07 [Ca] + 0.021 [Fe + Ni] as given by [3]. (Elemental abundance [x] in weight %, P(sub)21 in 10^10 cm^3 STP/g, Ma). Average cosmic-ray exposure ages were derived from as many nuclei as possible for 14 HEDs analyzed by us (see also [5,6]) and for those compiled by [7]. Two major exposure age clusters at 21 and 38 Ma are represented in all three meteorite classes (Fig. 1). In the cluster at 21 +- 4 Ma are 12 out of 39 eucrites, 6 out of 14 howardites, and 7out of 12 diogenites. In the cluster at 38 +- 8 Ma are 6 eucrites, 5 howardites, and 4 diogenites. A third common break-up event at 5 +- 1 Ma is indicated by the remaining diogenite, three eucrites, and one howardite. Schultz [8] found major clusters for eucrites at 13, 21, 26, and 40 Ma for howardites around 10 and 24 Ma, and for

  7. Experimental Physical Sciences Vistas: MaRIE (draft)

    SciTech Connect

    Shlachter, Jack

    2010-09-08

    To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materials science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national security

  8. First results from PuMa: The Dutch Pulsar machine

    NASA Astrophysics Data System (ADS)

    Stappers, B. W.; Ramachandran, R.; Kouwenhoven, M.; Voute, L.

    1998-12-01

    A new pulsar machine, called PuMa, has been developed in the Netherlands and has recently been installed at the Westerbork Synthesis Radio Telescope. PuMa takes advantage of high speed DSPs to carry out FFTs of the incoming data rather than the traditional filter approach to sampling the bandpass. This enables the formation of very fine frequency channels thus greatly improving the ability to correct for dispersion across the bandpass. The system is also very versatile allowing the approriate number channels to be chosen for a particular experiment. As the data are sampled at 20 MHz very high time resolution can also be acheived. It is also possible to record 10 MHz of raw bandwidth which can be coherently dedispersed off-line. I will present the initial results from a number of projects which we are undertaking, including a globular cluster survey, high resolution pulse studies and polarimetry.

  9. Adiabatic modulation of cnoidal wave by Kuznetsov - Ma soliton

    NASA Astrophysics Data System (ADS)

    Makarov, V. A.; Petnikova, V. M.; Shuvalov, V. V.

    2016-08-01

    The problem of nonlinear interaction of a cnoidal wave (a “fast” component of vector light field) with localized in time and periodic in space control signal in the form of Kuznetsov-Ma soliton (a "slow" component of the same field) is analytically solved in the adiabatic approximation. The conditions which must be fulfilled for stable propagation of the obtained solution with amplitude and frequency modulation are determined.

  10. Entropic derivation of F=ma for circular motion

    NASA Astrophysics Data System (ADS)

    Duncan, Michael; Singleton, Douglas; Myrzakulov, Ratbay

    2011-11-01

    We examine the entropic picture of Newton's second law for the case of circular motion. It is shown that one must make modifications to the derivation of F = ma due to a change in the effective Unruh temperature for circular motion. These modifications present a challenge to the entropic derivation of Newton's second law, but also open up the possibility to experimentally test and constrain this model for large centripetal accelerations. (Phys. Lett. B 703 (2011) 516-518)

  11. Design of a 500 MJ, 5 MA power supply

    NASA Astrophysics Data System (ADS)

    Pappas, J. A.; Headifen, G. R.; Weldon, J. M.; Wright, J. C.; Zowarka, R. C.; Aanstoos, T. A.; Kajs, J. H.

    1993-01-01

    The design of a 500 MJ, 5 MA power supply for rail gun experiments under the Battery Upgraded Supply (BUS) program is examined. About 50,000 12-volt lead acid batteries are required to reach this level. BUS will be required to perform up to two discharges per week. Therefore, BUS is designed to be a low-maintenance, reliable, and fault-tolerant power supply. The design of BUS and the details of its subsystems are described.

  12. Effect of the European design of TBMs on ITER wall loads due to fast ions in the baseline (15 MA), hybrid (12.5 MA), steady-state (9 MA) and half-field (7.5 MA) scenarios

    NASA Astrophysics Data System (ADS)

    Kurki-Suonio, T.; Äkäslompolo, S.; Särkimäki, K.; Varje, J.; Asunta, O.; Cavinato, M.; Gagliardi, M.; Hirvijoki, E.; Parail, V.; Saibene, G.; Sipilä, S.; Snicker, A.

    2016-11-01

    We assess the effect of the European design of the pebble-bed helium-cooled test blanket modules (TBM) on fast ion power loads on ITER material surfaces. For this purpose, the effect of not only the TBMs but also the ferritic inserts (FI), used for mitigating the toroidal field ripple, were included in unprecedented detail in the reconstruction of the 3-dimensional magnetic field. This is important because, due to their low collisionality, fast ions follow the magnetic geometry much more faithfully than the thermal plasma. The Monte Carlo orbit-following code ASCOT was used to simulate all the foreseen operating scenarios of ITER: the baseline 15 MA standard H-mode operation, the 12.5 MA hybrid scenario, the 9 MA advanced scenario, and the half-field scenario with helium plasma that will be ITER’s initial operating scenario. The effect of TBMs was assessed by carrying out the simulations in pairs: one including only the effect of ferritic inserts, and the other including also the perturbation due to TBMs. Both thermonuclear fusion alphas and NBI ions from ITER heating beams were addressed. The TBMs are found to increase the power loads, but the absolute values remain small. Neither do they produce any additional hot spots.

  13. PuMa, the first fully digital pulsar machine.

    NASA Astrophysics Data System (ADS)

    van Haren, P. C.; Voute, J. L. L.; Beijaard, T. D.; Driesens, D.; Kouwenhoven, M. L. A.; Langerak, J. J.

    2000-04-01

    Pulsars are neutron stars, rapidly rotating remains of supernova explosions, emitting bundles of broadband electromagnetic radiation. To carry out pulsar observations, two hurdles have to be overcome. Typically, the signal-to-noise ratio is poor, requiring long observations and large bandwidths. Next there is dispersion, causing the pulsating signals to smear out and calls for narrow signal bands. PuMa, the first Dutch pulsar machine, uses digital signal processing to split the incoming signal in up to thousands of narrow bands. The processor based design also increases flexibility as it allows different observational modes by loading the appropriate software into the signal processors. In total 192 SHARC processors (ADSP 21062) deliver the processing capacity. For PuMa a general purpose 6-processor SHARC board was developed, optimized for concurrent use of data busses. Other parts are commercially available components and all is joined in a VME environment. Mid 1998 PuMa was installed at the Westerbork Synthesis Radio Telescope in the Netherlands and its commissioning is completed.

  14. SCHeMA web-based observation data information system

    NASA Astrophysics Data System (ADS)

    Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

    2016-04-01

    It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by

  15. MA_MISS: Mars Multispectral Imager for Subsurface Studies

    NASA Astrophysics Data System (ADS)

    De Sanctis, M. C.; Coradini, A.; Ammannito, E.; Boccaccini, A.; Di Iorio, T.; Battistelli, E.; Capanni, A.

    2012-04-01

    A Drilling system, coupled with an in situ analysis package, is installed on the ExoMars Pasteur Rover to perform in situ investigations up to 2m in the Mars soil. Ma_Miss (Mars Multispectral Imager for Subsurface Studies) is a spectrometer devoted to observe the lateral wall of the borehole generated by the Drilling system. The instrument is fully integrated with the Drill and shares its structure and electronics. For the first time in Mars exploration experiments the water/geochemical environment will be investigated as function of depth in the shallow subsurface. Samples from the subsurface of Martian soil are unaltered by weathering process, oxidation and erosion. Subsurface access can be the key to look for signs of present and past environmental conditions, associated to the possibility for life (water, volatiles and weathering process). The analysis of uncontaminated samples by means of instrumented Drill and in situ observations is the solution for unambiguous interpretation of the original environment that leading to the formation of rocks. Ma_Miss experiment is perfectly suited to perform multispectral imaging of the drilled layers. Ma_Miss is a miniaturized near-infrared imaging spectrometer in the range 0.4-2.2 µm with 20nm spectral sampling. The task of illuminating the borehole wall and collecting the diffused light from the illuminated spot on the target requires a transparent window on the Drill tool, which shall prevent the dust contamination of the optical and mechanical elements inside. Hardness of sapphire is the closest to diamond one, thus avoiding the risk of scratches on its surface. The Sapphire window is cylindrical, and bounded such as to realize a continuous auger profile. Ma_Miss Optical Head performs the double task of illuminating the borehole wall with a spot around 1 mm diameter and of collecting the scattered light coming from a 0.1 mm diameter spot of the target. The signal from the Optical Head to the spectrometer is transferred

  16. Neuroprotective Effect of Gui Zhi (Ramulus Cinnamomi) on Ma Huang- (Herb Ephedra-) Induced Toxicity in Rats Treated with a Ma Huang-Gui Zhi Herb Pair

    PubMed Central

    Zheng, Fang-hao; Wei, Ping; Huo, Hui-ling; Xing, Xue-feng; Chen, Fei-long; Tan, Xiao-mei; Luo, Jia-bo

    2015-01-01

    Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination. PMID:25691910

  17. Neuroprotective effect of gui zhi (ramulus cinnamomi) on ma huang- (herb ephedra-) induced toxicity in rats treated with a ma huang-gui zhi herb pair.

    PubMed

    Zheng, Fang-Hao; Wei, Ping; Huo, Hui-Ling; Xing, Xue-Feng; Chen, Fei-Long; Tan, Xiao-Mei; Luo, Jia-Bo

    2015-01-01

    Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination.

  18. Level II scour analysis for Bridge 28 (CAMBTH00460028) on Town Highway 46, crossing the Seymour River, Cambridge, Vermont

    USGS Publications Warehouse

    Ivanoff, Michael A.

    1997-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure CAMBTH00460028 on Town Highway 46 crossing the Seymour River, Cambridge, Vermont (figures 1–8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (U.S. Department of Transportation, 1993). Results of a Level I scour investigation also are included in Appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in Appendix D. The site is in the Green Mountain section of the New England physiographic province in northwestern Vermont. The 9.94-mi2 drainage area is in a predominantly rural and forested basin. In the vicinity of the study site, the surface cover is pasture while the immediate banks have dense woody vegetation. In the study area, the Seymour River has an incised, straight channel with a slope of approximately 0.02 ft/ft, an average channel top width of 81 ft and an average bank height of 5 ft. The channel bed material ranges from gravel to boulder with a median grain size (D50) of 62.0 mm (0.204 ft). The geomorphic assessment at the time of the Level I and Level II site visit on July 11, 1995, indicated that the reach was stable. The Town Highway 46 crossing of the Seymour River is a 38-ft-long, one-lane bridge consisting of one 33-foot steel-beam span (Vermont Agency of Transportation, written communication, March 8, 1995). The opening length of the structure parallel to the bridge face is 30.6 ft.The bridge is supported by vertical, concrete abutments with wingwalls. The channel is skewed approximately 5 degrees to the opening while the measured opening-skew-to-roadway is 10 degrees. A scour hole 0.2 ft deeper than the mean thalweg depth was observed along the

  19. Level II scour analysis for Bridge 53 (CAMBTH00750053) on Town Highway 75, crossing the Brewster River, Cambridge, Vermont

    USGS Publications Warehouse

    Ivanoff, Michael A.; Hammond, Robert E.

    1997-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure CAMBTH00750053 on Town Highway 75 crossing the Brewster River, Cambridge, Vermont (figures 1–8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (U.S. Department of Transportation, 1993). Results of a Level I scour investigation also are included in Appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in Appendix D. The site is in the Green Mountain section of the New England physiographic province in northwestern Vermont. The 4.30-mi2 drainage area is in a predominantly rural and forested basin. In the vicinity of the study site, the surface cover is forest, except for the downstream right overbank area which has a barn surrounded by grass and shrubs. In the study area, the Brewster River has an incised, straight channel with a slope of approximately 0.05 ft/ft, an average channel top width of 62 ft and an average bank height of 12 ft. The channel bed material ranges from gravel to boulder with a median grain size (D50) of 84.4 mm (0.277 ft). The geomorphic assessment at the time of the Level I and Level II site visit on July 11, 1995, indicated that the reach was stable. The Town Highway 75 crossing of the Brewster River is a 28-ft-long, two-lane bridge consisting of one 24-foot concrete tee-beam span (Vermont Agency of Transportation, written communication, March 8, 1995). The opening length of the structure parallel to the bridge face is 22.4 ft. The bridge is supported by vertical, concrete abutments with wingwalls. The channel is skewed approximately 40 degrees to the opening while the opening-skew-to-roadway as surveyed is 10 degrees. A scour hole 1 ft

  20. The ADDITION-Cambridge trial protocol: a cluster – randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients

    PubMed Central

    Echouffo-Tcheugui, Justin B; Simmons, Rebecca K; Williams, Kate M; Barling, Roslyn S; Prevost, A Toby; Kinmonth, Ann Louise; Wareham, Nicholas J; Griffin, Simon J

    2009-01-01

    Background The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain. Methods and design The ADDITION-Cambridge study aims to evaluate the effectiveness and cost-effectiveness of (i) a stepwise screening strategy for type 2 diabetes; and (ii) intensive multifactorial treatment for people with screen-detected diabetes in primary care. 63 practices in the East Anglia region participated. Three undertook the pilot study, 33 were allocated to three groups: no screening (control), screening followed by intensive treatment (IT) and screening plus routine care (RC) in an unbalanced (1:3:3) randomisation. The remaining 27 practices were randomly allocated to IT and RC. A risk score incorporating routine practice data was used to identify people aged 40–69 years at high-risk of undiagnosed diabetes. In the screening practices, high-risk individuals were invited to take part in a stepwise screening programme. In the IT group, diabetes treatment is optimised through guidelines, target-led multifactorial treatment, audit, feedback, and academic detailing for practice teams, alongside provision of educational materials for newly diagnosed participants. Primary endpoints are modelled cardiovascular risk at one year, and cardiovascular mortality and morbidity at five years after diagnosis of diabetes. Secondary endpoints include all-cause mortality, development of renal and visual impairment, peripheral neuropathy, health service costs, self-reported quality of life, functional status and health utility. Impact of the screening programme at the population level is also assessed through measures of mortality, cardiovascular morbidity, health status and health service use among high-risk individuals. Discussion ADDITION-Cambridge is conducted in a defined high-risk group accessible through primary

  1. 75 FR 435 - Notice of Inventory Completion: Department of Anthropology, University of Massachusetts, Amherst, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ...: Department of Anthropology, University of Massachusetts, Amherst, MA AGENCY: National Park Service, Interior... the possession and control of the Department of Anthropology, University of Massachusetts, Amherst, MA... Department of Anthropology, University of Massachusetts, Amherst professional staff in consultation...

  2. 78 FR 58882 - Safety Zone; Chelsea River, Boston Inner Harbor, Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... means for vehicles to travel between Chelsea, MA and East Boston, MA. Several petroleum-product transfer... passage through the Chelsea Street Bridge based on vessel dimensional criteria, assist tug support,...

  3. Astronaut Scott Carpenter being recovered from Ocean after MA-7 flight

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Astronaut M. Scott Carpenter, prime pilot for the Mercury-Atlas 7 (MA-7) mission, is seen being recovered from Atlantic Ocean after MA-7 flight. A diver helps Carpenter into a life raft while the capsule floats nearby.

  4. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that plan only to members of the church, or convention or group of churches with which the society...

  5. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that plan only to members of the church, or convention or group of churches with which the...

  6. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Enrollment § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that plan only to members of the church, or convention or group of churches with which the...

  7. 42 CFR 422.57 - Limited enrollment under MA RFB plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 422.57 Limited enrollment under MA RFB plans. An RFB society that offers an MA RFB plan may offer that plan only to members of the church, or convention or group of churches with which the society...

  8. SDSS-IV/MaNGA: Spectrophotometric Calibration Technique

    NASA Astrophysics Data System (ADS)

    Yan, Renbin; Tremonti, Christy; Bershady, Matthew A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Cherinka, Brian; Eigenbrot, Arthur; Gunn, James E.; Harding, Paul; Hogg, David W.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Wake, David A.; Weijmans, Anne-Marie; Xiao, Ting; Zhang, Kai

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600-10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  9. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    SciTech Connect

    Yan, Renbin; Sánchez-Gallego, José R.; Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Hogg, David W.; Cherinka, Brian; Gunn, James E.; Harding, Paul; Sánchez, Sebastian F.; and others

    2016-01-15

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  10. BioMaPS: A Roadmap for Success

    PubMed Central

    Fister, K. Renee

    2010-01-01

    The manuscript outlines the impact that our National Science Foundation Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences program, BioMaPS, has had on the students and faculty at Murray State University. This interdisciplinary program teams mathematics and biology undergraduate students with mathematics and biology faculty and has produced research insights and curriculum developments at the intersection of these two disciplines. The goals, structure, achievements, and curriculum initiatives are described in relation to the effects they have had to enhance the study of biomathematics. PMID:20810948

  11. Advanced Query and Data Mining Capabilities for MaROS

    NASA Technical Reports Server (NTRS)

    Wang, Paul; Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Hy, Franklin H.

    2013-01-01

    The Mars Relay Operational Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay network. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. As part of MaROS, the innovators have developed and implemented a feature set that operates on several levels of the software architecture. This new feature is an advanced querying capability through either the Web-based user interface, or through a back-end REST interface to access all of the data gathered from the network. This software is not meant to replace the REST interface, but to augment and expand the range of available data. The current REST interface provides specific data that is used by the MaROS Web application to display and visualize the information; however, the returned information from the REST interface has typically been pre-processed to return only a subset of the entire information within the repository, particularly only the information that is of interest to the GUI (graphical user interface). The new, advanced query and data mining capabilities allow users to retrieve the raw data and/or to perform their own data processing. The query language used to access the repository is a restricted subset of the structured query language (SQL) that can be built safely from the Web user interface, or entered as freeform SQL by a user. The results are returned in a CSV (Comma Separated Values) format for easy exporting to third party tools and applications that can be used for data mining or user-defined visualization and interpretation. This is the first time that a service is capable of providing access to all cross-project relay data from a single Web resource. Because MaROS contains the data for a variety of missions from the Mars network, which span both NASA and ESA, the software also establishes an access control list (ACL) on each data record

  12. Factors affecting reservoir and stream-water quality in the Cambridge, Massachusetts, drinking-water source area and implications for source-water protection

    USGS Publications Warehouse

    Waldron, Marcus C.; Bent, Gardner C.

    2001-01-01

    This report presents the results of a study conducted by the U.S. Geological Survey, in cooperation with the city of Cambridge, Massachusetts, Water Department, to assess reservoir and tributary-stream quality in the Cambridge drinking-water source area, and to use the information gained to help guide the design of a comprehensive water-quality monitoring program for the source area. Assessments of the quality and trophic state of the three primary storage reservoirs, Hobbs Brook Reservoir, Stony Brook Reservoir, and Fresh Pond, were conducted (September 1997-November 1998) to provide baseline information on the state of these resources and to determine the vulnerability of the reservoirs to increased loads of nutrients and other contaminants. The effects of land use, land cover, and other drainage-basin characteristics on sources, transport, and fate of fecal-indicator bacteria, highway deicing chemicals, nutrients, selected metals, and naturally occurring organic compounds in 11 subbasins that contribute water to the reservoirs also was investigated, and the data used to select sampling stations for incorporation into a water-quality monitoring network for the source area. All three reservoirs exhibited thermal and chemical stratification, despite artificial mixing by air hoses in Stony Brook Reservoir and Fresh Pond. The stratification produced anoxic or hypoxic conditions in the deepest parts of the reservoirs and these conditions resulted in the release of ammonia nitrogen orthophosphate phosphorus, and dissolved iron and manganese from the reservoir bed sediments. Concentrations of sodium and chloride in the reservoirs usually were higher than the amounts recommended by the U.S. Environmental Protection agency for drinking-water sources (20 milligrams per liter for sodium and 250 milligrams per liter for chloride). Maximum measured sodium concentrations were highest in Hobbs Brook Reservoir (113 milligrams per liter), intermediate in Stony Brook Reservoir (62

  13. Technical note: the effect of refractive blur on colour vision evaluated using the Cambridge Colour Test, the Ishihara Pseudoisochromatic Plates and the Farnsworth Munsell 100 Hue Test.

    PubMed

    Thyagarajan, Sri; Moradi, Philip; Membrey, Luke; Alistair, D; Laidlaw, H

    2007-05-01

    The results of a prospective study examining the effect of refractive blur on colour vision performance in normal subjects measured with three different colour vision tests are reported. The Farnsworth Munsell 100 Hue (FM100) and Cambridge Colour Test (CCT) results were significantly affected at +6 D of spherical refractive blur, whereas those from the Ishihara Pseudoisochromatic Plate (IPP) test were not. In a clinical setting, correction of refractive error up to 3 D for colour vision testing with these tests may not be required. Poor colour vision should not be attributed solely to refractive causes of poor visual acuity (Snellen equivalent: >6/36). Fastest test times were achieved using IPP, followed by CCT.

  14. More on the spider genus Xeropigo O.P.-Cambridge (Araneae, Corinnidae, Corinninae): seven new species and new records from Brazil.

    PubMed

    Carvalho, Leonardo S; Shimano, Yulie; Candiani, David F; Bonaldo, Alexandre B

    2016-05-17

    Seven new species of the spider genus Xeropigo O. P.-Cambridge are described from Brazil, increasing the genus member list up to 16 species. X. piripiri n. sp., X. aitatu n. sp., and X. cajuina n. sp. are described from the state of Piauí. X. crispim n. sp. is described from the states of Ceará, Piauí, and Maranhão. X. oxente n. sp. is described from the state of Rio Grande do Norte. X. canga n. sp. is described from the state of Minas Gerais. X. ufo n. sp. is described from the state of Mato Grosso. The geographical distribution of X. tridentiger, X. camilae, X. pachitea, and X. perene is updated. A key to all species of Xeropigo is presented and possible relationships among all species of the genus are discussed.

  15. Notes on the genus Harmonicon F.O.P.-Cambridge, 1896 (Araneae, Dipluridae) with description of a new species from French Guyana

    PubMed Central

    Drolshagen, Bastian; Bäckstam, Christian M.

    2011-01-01

    Abstract Information on the genus Harmonicon F.O.P.-Cambridge, 1896, a key to the species and a new diagnosis differing from the one in Maréchal and Marty (1998) are provided. A new species is described: Harmonicon oiapoqueae differing from other species of the genus by the morphology of the posterior sternal sigilla, the more recurved, inverted U–shaped fovea, the amount and arrangement of maxillary cuspules, a single row of teeth on the claws of the palpal tarsus, longer and more slender legs III and IV in females, longer embolus, thinner bulb, and longer, more slender legs in males. The status of the putative junior synonyms of Harmonicon, Pseudohermachura Mello-Leitão, 1927 and Prosharmonicon Mello-Leitão, as well as the two species formerly assigned to Harmonicon, Harmonicon nigridorsi Mello-Leitão, 1924 and Harmonicon riveti Simon, 1903, is discussed. PMID:21976989

  16. Documentation for the machine-readable version of the Fourth Cambridge Radio Survey Catalogue (4C) (Pilkington, Gower, Scott and Wills 1965, 1967)

    NASA Technical Reports Server (NTRS)

    Warren, W. H., Jr.

    1983-01-01

    The machine readable catalogue contains survey data from the papers of Pilkington and Scott and Gower, Scott and Wills. These data result from a survey of radio sources between declinations -07 deg and +80 deg using the large Cambridge interferometer at 178 MHz. The computerized catalog contains for each source the 4C number, 1950 position, measured flux density, and accuracy class. For some sources miscellaneous brief comments such as cross identifications to the 3C catalog or remarks on contamination from nearby sources are given at the ends of the data records. A detailed description of the machine readable catalog as it is currently being distributed by the Astronomical Data Center is given to enable users to read and process the data.

  17. Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015.

    PubMed

    Williams, David J; Archer, Richard; Archibald, Peter; Bantounas, Ioannis; Baptista, Ricardo; Barker, Roger; Barry, Jacqueline; Bietrix, Florence; Blair, Nicholas; Braybrook, Julian; Campbell, Jonathan; Canham, Maurice; Chandra, Amit; Foldes, Gabor; Gilmanshin, Rudy; Girard, Mathilde; Gorjup, Erwin; Hewitt, Zöe; Hourd, Paul; Hyllner, Johan; Jesson, Helen; Kee, Jasmin; Kerby, Julie; Kotsopoulou, Nina; Kowalski, Stanley; Leidel, Chris; Marshall, Damian; Masi, Louis; McCall, Mark; McCann, Conor; Medcalf, Nicholas; Moore, Harry; Ozawa, Hiroki; Pan, David; Parmar, Malin; Plant, Anne L; Reinwald, Yvonne; Sebastian, Sujith; Stacey, Glyn; Thomas, Robert J; Thomas, Dave; Thurman-Newell, Jamie; Turner, Marc; Vitillo, Loriana; Wall, Ivan; Wilson, Alison; Wolfrum, Jacqueline; Yang, Ying; Zimmerman, Heiko

    2016-07-01

    This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information and references to related information added subsequently to the workshop. Comparability is the need to demonstrate equivalence of product after a process change; a recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore a well-managed change process is required which needs access to good science and regulatory advice and developers are encouraged to seek help early. The workshop shared current thinking and best practice and allowed the definition of key research questions. The intent of this report is to summarize the key issues and the consensus reached on each of these by the expert delegates.

  18. 42 CFR 422.56 - Enrollment in an MA MSA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Enrollment in an MA MSA plan. 422.56 Section 422.56... Enrollment in an MA MSA plan. (a) General. An individual is not eligible to elect an MA MSA plan unless the... Department of Defense under 38 U.S.C. chapter 17, may not enroll in an MA MSA plan. (c) Individuals...

  19. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of...

  20. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of...

  1. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Effect of leasing of an MA organization's... Change of Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of...

  2. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of...

  3. Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA)

    SciTech Connect

    Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa; Yoon, Hyun-Joo; Yoo, Hae Yong; Choi, Cheol Yong

    2014-01-03

    Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis.

  4. 42 CFR 422.553 - Effect of leasing of an MA organization's facilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Effect of leasing of an MA organization's... Ownership or Leasing of Facilities During Term of Contract § 422.553 Effect of leasing of an MA organization's facilities. (a) General effect of leasing. If an MA organization leases all or part of...

  5. Oxidation of Inconel alloy MA754 at low oxidation potential

    SciTech Connect

    Braski, D.N.; Goodell, P.D.; Cathcart, J.V.; Kane, R.H.

    1983-01-01

    It has been known for some time that the addition of small oxide particles to an 80 Ni-20 Cr alloy not only increases its elevated-temperature strength, but also markedly improves its resistance to oxidation. The mechanism by which the oxide dispersoid enhances the oxidation resistance was studied. Initial experiments were performed using inconel alloy MA754, which is nominally: 78 Ni, 20 Cr, 0.05 C, 0.3 Al, 0.5 Ti, 1.0 Fe, and 0.6 Y/sub 2/O/sub 3/ (wt %). Small disks (3 mm diam x 0.38 mm thick) were cut from MA754 plate stock and prepared with two different surface conditions. The first was prepared by mechanically polishing one side of a disk through 0.5 ..mu..m diamond on a syntron polisher while the second used an additional sulfuric acid-methanol electropolishing treatment to remove the cold-worked surface layer. Disks having both surface treatments were oxidized in a radiantly heated furnace for 30 s at 1000/sup 0/C. Three different environments were investigated: hydrogen with nominal dew points of 0/sup 0/C, -25/sup 0/C, and -55/sup 0/C. The oxide particles and films were examined in TEM by using extraction replicas (carbon) and by backpolishing to the oxide/metal interface. The particles were analyzed by EDS and SAD. Preliminary results are given.

  6. Selective laser sintering of MA956 oxide dispersion strengthened steel

    NASA Astrophysics Data System (ADS)

    Hunt, Ryan M.; Kramer, Kevin J.; El-Dasher, Bassem

    2015-09-01

    Oxide Dispersion Strengthened (ODS) steels' qualities of radiation damage resistance and high strength at high temperature make them promising nuclear structural materials. However, the dispersed yttria that gives ODS steel its beneficial qualities are generally compromised during joining processes, making fabrication difficult and expensive. The selective laser sintering process offers a potential path through this barrier by which net-shape parts can feasibly be built via additive manufacturing without fully melting the structure. Rastering a 400 W laser over a 110 μm MA956 ODS steel powder bed, we additively built parts with varying build conditions. Although density was achieved to within 97% of the wrought MA956, ultimate tensile strengths achieved only 65% of the wrought strength. Spectroscopy analysis points to the agglomeration of the yttria nano-particles as a possible explanation for the loss in strength. Further study might benefit from exploration of other parameters such as thinner powder build layers which would require less energy input to achieve sintering while minimizing time above the melting temperature.

  7. Topography of Apollinaris Patera and Ma'adim Vallis

    NASA Technical Reports Server (NTRS)

    Thornhill, G. D.; Rothery, D. A.; Murray, J. B.; Day, T.; Cook, A.; Muller, J.-P.; Iliffe, J. C.

    1992-01-01

    Digital elevation models of the northern part of Ma'adim Vallis (603a41 607m/pix, 639a91 721m/pix), and Apollinaris Patera (603a42 612m/pix, 639a92 717m/pix), covering the area between 180 degrees to 190 degrees long and -2 degrees to -20 degrees lat. were obtained using a method described here. The results for the Ma'adim Vallis area show broad agreement with the United States Geological Survey (USGS) topographic map of the area with a channel depth of 1 to 2 km. A detailed study of the variations in the channel depth along its course and calculations of its discharge rate from channel cross section and slope are currently being undertaken. Results for Apollinaris Patera have been obtained, although the absolute heights relative to the Mars datum are not well constrained. However, the relative heights are sufficient for some analysis. Again, the topographic map is in reasonable agreement with the USGS map of the area, although there are significant differences.

  8. MaROS Strategic Relay Planning and Coordination Interfaces

    NASA Technical Reports Server (NTRS)

    Allard, Daniel A.

    2010-01-01

    The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

  9. Relationship between methamphetamine use history and segmental hair analysis findings of MA users.

    PubMed

    Han, Eunyoung; Lee, Sangeun; In, Sanghwan; Park, Meejung; Park, Yonghoon; Cho, Sungnam; Shin, Junguk; Lee, Hunjoo

    2015-09-01

    The aim of this study was to investigate the relationship between methamphetamine (MA) use history and segmental hair analysis (1 and 3cm sections) and whole hair analysis results in Korean MA users in rehabilitation programs. Hair samples were collected from 26 Korean MA users. Eleven of the 26 subjects used cannabis with MA and two used cocaine, opiates, and MDMA with MA. Self-reported single dose of MA from the 26 subjects ranged from 0.03 to 0.5g/one time. Concentrations of MA and its metabolite amphetamine (AP) in hair were determined by gas chromatography mass spectrometry (GC/MS) after derivatization. The method used was well validated. Qualitative analysis from all 1cm sections (n=154) revealed a good correlation between positive or negative results for MA in hair and self-reported MA use (69.48%, n=107). In detail, MA results were positive in 66 hair specimens of MA users who reported administering MA, and MA results were negative in 41 hair specimens of MA users who denied MA administration in the corresponding month. Test results were false-negative in 10.39% (n=16) of hair specimens and false-positive in 20.13% (n=31) of hair specimens. In false positive cases, it is considered that after MA cessation it continued to be accumulated in hair still, while in false negative cases, self-reported histories showed a small amount of MA use or MA use 5-7 months previously. In terms of quantitative analysis, the concentrations of MA in 1 and 3cm long hair segments and in whole hair samples ranged from 1.03 to 184.98 (mean 22.01), 2.26 to 89.33 (mean 18.71), and 0.91 to 124.49 (mean 15.24)ng/mg, respectively. Ten subjects showed a good correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 7 among 10 subjects ranged from 0.71 to 0.98 (mean 0.85). Four subjects showed a low correlation between MA use and MA concentration in hair. Correlation coefficient (r) of 4 subjects ranged from 0.36 to 0.55. Eleven subjects showed a poor

  10. Mexican data indicating ca.700 Ma breakup of Rodinia and ca.550 Ma separation of Avalonia: analogous to events in western Laurentia

    NASA Astrophysics Data System (ADS)

    Keppie, J. D.; Nance, R. D.; Miller, B. V.; Dostal, J.

    2004-05-01

    The supercontinent, Rodinia, appears to have been amalgamated by ca.1 Ga, however, its breakup in Laurentia appears to have occurred in two stages. Current hypotheses suggest that East Gondwana or Siberia separated from western Laurentia at ca.700 Ma followed by separation of (?) South China at ca.550 Ma producing two superposed passive margin sequences. Although prevailing wisdom suggests that the birth of Iapetus between North and South America occurred at ca.550 Ma, a similar 2-stage process is evident in both eastern Laurentia and Mexico. At ca.1 Ga, Mexico appears to have been located in or close to the North-South America suture and so provides crucial data. Geochronological data indicate that cooling following ca.1 Ga granulite facies orogenesis in Mexico followed two different paths. In southern Mexico the rocks initially cooled through ca.450° C at a rate of ca.8° C/my between 978 Ma and 945 Ma related to flat-slab subduction, followed by a cooling rate of ca.2° C/my through ca.150° C. In northern Mexico the rocks cooled at a steady rate of ca.1.8° C/my through ca.300° C and are cut by plume-related mafic dykes. Extrapolating these cooling paths to the surface indicates that southern Mexico reached the surface between 710 and 760 Ma, whereas northern Mexico reached the surface by 550 Ma. This may be partly explained by different depths of exhumation: 30 versus 37 km for southern and northern Mexico, respectively. On the other hand, the oldest rocks resting on the ca.1 Ga basement are Tremadocian (ca.490-480 Ma) in southern Mexico and Middle Silurian (ca.430-425 Ma) in northern Mexico. Thus it would appear that Mexico records two breakup stages: (1) at ca.700 Ma possibly related to the breakup of Rodinia; (2) at ca.550 Ma possibly related to the transcurrent separation of Avalonia followed by thermal equilibration at ca.500 Ma leading to subsidence and development of a passive margin. These data suggest that the breakup of Rodinia occurred at ca.700

  11. Evidence for an extensive Antarctic Ice Sheet by 37 Ma

    NASA Astrophysics Data System (ADS)

    Carter, Andrew; Riley, Teal; Hillenbrand, Claus-Dieter; Rittner, Martin

    2016-04-01

    We present observational evidence that both the East and West Antarctic ice sheets had expanded to the coast by 37 Ma, predating, by at least 3 Myr, a major drop in atmospheric CO2 at the Eocene-Oligocene boundary widely considered responsible for Antarctic Ice Sheet expansion. Our evidence comes from the provenance (geochronology, thermochronometry, mineralogy) of iceberg-rafted debris identified in Late Eocene marine sediments from (ODP) Leg 113 Site 696 in the NW Weddell Sea. The existence of an significant Antarctic Ice Sheet in a Late Eocene high pCO2 world calls into question the role of atmospheric CO2 concentrations as the dominant mechanism for ice sheet expansion and whether topography and ocean circulation only play a secondary role.

  12. Random Fields, Topology, and the Imry-Ma Argument

    NASA Astrophysics Data System (ADS)

    Proctor, Thomas C.; Garanin, Dmitry A.; Chudnovsky, Eugene M.

    2014-03-01

    We consider an n-component fixed-length order parameter interacting with a weak random field in d =1, 2, 3 dimensions. Relaxation from the initially ordered state and spin-spin correlation functions are studied on lattices containing hundreds of millions of sites. At n≤d the presence of topological defects leads to strong metastability and glassy behavior, with the final state depending on the initial condition. At n=d+1, when topological structures are nonsingular, the system possesses a weak metastability. At n>d+1, when topological objects are absent, the final, lowest-energy state is independent of the initial condition. It is characterized by the exponential decay of correlations that agrees quantitatively with the theory based upon the Imry-Ma argument.

  13. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

    PubMed Central

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M.

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([11C]MA2) and a fluorine-18 ([18F]MA3) labeled analog of a highly potent N-arylamide oxadiazole CB2 agonist (EC50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC50: 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for hCB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC50 values when compared to the originally reported trifluoromethyl analog 12. [11C]MA2 and [18F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [11C]MA2 and [18F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted. PMID:27713686

  14. MaTeLo: Automated Testing Suite for Software Validation

    NASA Astrophysics Data System (ADS)

    Guiotto, A.; Acquaroli, B.; Martelli, A.

    It is universally known that testing has a predominant role when developing software: more and more efforts are spent on testing to detect programming faults, to evaluate the code reliability or performance, to ensure that a critical function of a system meets given requirements. The ratio of time spent on testing should not be neglected and this explains why there is a real need to improve the development process, especially as systems are becoming larger and larger. It is necessary to keep under control the schedule and budget of developments, and controlling the testing phase is a real issue, often underestimated in many industrial sectors. The industry is heightened at different stages regarding testing, and the MaTeLo project is committed to promote the use of statistical tools &methods to answer European industry's needs: • have the ability to choose relevant test cases instead of a human- biased selection • know when to stop testing (definition of a stopping criteria) instead of a vague and informal criteria • adopt an identical strategy for different developments • automate the testing process, and thus to make testing not human error prone MaTeLo (Markov Test Logic) study is a study currently under development in the frame of the IST program of the European Community. The aim of the project is to define, implement and validate a new approach for supporting the software testing activities in various industrial fields. One of the major goals is in particular to provide the software teams with a new tool able to automatically produce and execute the Test Cases starting from the software specifications. Further, the tool is conceived to provide metrics that could help technical staff to determine software quality and to evaluate how much expected results are met. The tool is based on Markov chains theory and belongs to statistical testing software tools family [Runeson] [Whittaker].

  15. Calmodulin Binds a Highly Extended HIV-1 MA Protein That Refolds Upon Its Release

    PubMed Central

    Taylor, James E.; Chow, John Y.H.; Jeffries, Cy M.; Kwan, Ann H.; Duff, Anthony P.; Hamilton, William A.; Trewhella, Jill

    2012-01-01

    Calmodulin (CaM) expression is upregulated upon HIV-1 infection and interacts with proteins involved in viral processing, including the multifunctional HIV-1 MA protein. We present here the results of studies utilizing small-angle neutron scattering with contrast variation that, when considered in the light of earlier fluorescence and NMR data, show CaM binds MA in an extended open-clamp conformation via interactions with two tryptophans that are widely spaced in sequence and space. The interaction requires a disruption of the MA tertiary fold such that MA becomes highly extended in a long snakelike conformation. The CaM-MA interface is extensive, covering ∼70% of the length of the MA such that regions known to be important in MA interactions with critical binding partners would be impacted. The CaM conformation is semiextended and as such is distinct from the classical CaM-collapse about short α-helical targets. NMR data show that upon dissociation of the CaM-MA complex, either by the removal of Ca2+ or increasing ionic strength, MA reforms its native tertiary contacts. Thus, we observe a high level of structural plasticity in MA that may facilitate regulation of its activities via intracellular Ca2+-signaling during viral processing. PMID:22947870

  16. Development of a Hydronic Rooftop Unit-HyPak-MA

    SciTech Connect

    Lee, Eric; Berman, Mark

    2009-11-14

    The majority of U.S. commercial floor space is cooled by rooftop HVAC units (RTUs). RTU popularity derives chiefly from their low initial cost and relative ease of service access without disturbing building occupants. Unfortunately, current RTUs are inherently inefficient due to a combination of characteristics that unnecessarily increase cooling loads and energy use. 36% percent of annual U.S. energy, and two-thirds of electricity, is consumed in and by buildings. Commercial buildings consume approximately 4.2 quads of energy each year at a cost of $230 billion per year, with HVAC equipment consuming 1.2 quads of electricity. More than half of all U.S. commercial floor space is cooled by packaged HVAC units, most of which are rooftop units (RTUs). Inefficient RTUs create an estimated 3.5% of U.S. CO{sub 2} emissions, thus contributing significantly to global warming5. Also, RTUs often fail to maintain adequate ventilation air and air filtration, reducing indoor air quality. This is the second HyPak project to be supported by DOE through NETL. The prior project, referred to as HyPak-1 in this report, had two rounds of prototype fabrication and testing as well as computer modeling and market research. The HyPak-1 prototypes demonstrated the high performance capabilities of the HyPak concept, but made it clear that further development was required to reduce heat exchanger cost and improve system reliability before HyPak commercialization can commence. The HyPak-1 prototypes were limited to about 25% ventilation air fraction, limiting performance and marketability. The current project is intended to develop a 'mixed-air' product that is capable of full 0-100% modulation in ventilation air fraction, hence it was referred to as HyPak-MA in the proposal. (For simplicity, the -MA has been dropped when referencing the current project.) The objective of the HyPak Project is to design, develop and test a hydronic RTU that provides a quantum improvement over conventional RTU

  17. Irregular Mare Patches (IMPs): 100 Ma or 3 Ga?

    NASA Technical Reports Server (NTRS)

    Stopar, Julie; Robinson, Mark Southwick; van der Bogert, Carolyn H.; Giguere, Thomas; Lawrence, Samuel J.; Ostrach, Lillian Rose; Clegg-Watkins, Ryan N.

    2016-01-01

    IMPs exhibit a perplexing combination of characteristics that are consistent with either an approximately 100 Ma or 3 Ga formation. Dozens of small-area IMPs have crisp morphologies and crater size-frequency distributions (SFDs) that denote relatively recent geologic activity (less than 100 Ma); however, the apparently well-developed regolith on portions of the IMPs are in conflict with such a young age [1]. To test possible formation hypotheses (e.g., [1-5]), which range from ancient volcanism to contemporary outgassing, we examined IMP morphology at the meter-scale with LROC NAC images and derived elevation models. We focused on the largest IMPs (Ina, Sosigenes, Cauchy, Maskelyne, and Nubium), where contacts between deposits are best developed. Most of our observations are consistent with multiple generations of inflation and breakouts (or squeeze-ups) of basaltic lavas that were affected by local slopes. Some of the extrusions coalesced into larger mounds or filled pre-existing craters. We did not observe evidence of large-scale void space (e.g., fissures, fractures, linear depressions, or pits) within or beneath the mounds or rougher deposits (e.g., [5]). But, small-scale voids may be signified by isolated pitted textures. We also did not detect evidence of the cooling fractures or lava plates expected in young lava flows and observed in lunar impact melt deposits. The smooth texture of the mounds is enigmatic. Block-less craters suggest at least 5 m of friable or poorly-cohesive material (such as regolith), yet mound margins exhibit slopes greater than 30 deg requiring significant material strength. Blocks are not common on the mounds, but are sometimes excavated by impacts (usually excavated from beneath the mounds). The uneven deposits are equally enigmatic and texturally varied (blocky, pitted, and crenulated). They are deficient in superposed craters compared to the mounds. If the mounds are indeed of similar age to the rougher units, then their different

  18. An analysis of infection control of varicella-zoster virus infections in Addenbrooke's Hospital Cambridge over a 5-year period, 1987-92.

    PubMed Central

    Wreghitt, T. G.; Whipp, J.; Redpath, C.; Hollingworth, W.

    1996-01-01

    This prospective study analyses infections with varicella-zoster virus (VZV) in Addenbrooke's Hospital, Cambridge during 1987-92 and examines the spread of infection. In total, 93 patients and staff experienced VZV infection. Twenty-one patients had varicella and 49 experienced zoster. None of 101 patients and 1 of 625 staff members in contact with varicella cases acquired infection. By contrast, 2 of 227 patients, and 5 of 1039 staff in contact with zoster cases acquired varicella. One out of 28 (3.6%) VZV antibody-negative patients and staff in contact with varicella acquired infection, compared with 5 out of 29 (17.2%) VZV antibody-negative patients and staff in contact with zoster. Thus, zoster was found to be a more frequent cause of nosocomial infection than varicella. Fourteen members of staff had VZV infection during the study period. One of 99 patients and none of 389 staff members in contact with these cases developed varicella. The cost of dealing with infection control for VZV infections in our hospital is estimated to be Pounds 714 per patient case and a total of Pounds 13,204 per year. PMID:8760965

  19. The conquest of vitalism or the eclipse of organicism? The 1930s Cambridge organizer project and the social network of mid-twentieth-century biology.

    PubMed

    Peterson, Erik

    2014-06-01

    In the 1930s, two concepts excited the European biological community: the organizer phenomenon and organicism. This essay examines the history of and connection between these two phenomena in order to address the conventional 'rise-and-fall' narrative that historians have assigned to each. Scholars promoted the 'rise-and-fall' narrative in connection with a broader account of the devitalizing of biology through the twentieth century. I argue that while limited evidence exists for the 'fall of the organizer concept' by the 1950s, the organicism that often motivated the organizer work had no concomitant fall--even during the mid-century heyday of molecular biology. My argument is based on an examination of shifting social networks of life scientists from the 1920s to the 1970s, many of whom attended or corresponded with members of the Cambridge Theoretical Biology Club (1932-1938). I conclude that the status and cohesion of these social networks at the micro scale was at least as important as macro-scale conceptual factors in determining the relative persuasiveness of organicist philosophy.

  20. An investigation into the impact of question structure on the performance of first year physics undergraduate students at the University of Cambridge

    NASA Astrophysics Data System (ADS)

    Gibson, Valerie; Jardine-Wright, Lisa; Bateman, Elizabeth

    2015-07-01

    We describe a study of the impact of exam question structure on the performance of first year Natural Sciences physics undergraduates from the University of Cambridge. The results show conclusively that a student’s performance improves when questions are scaffolded compared with university style questions. In a group of 77 female students we observe that the average exam mark increases by 13.4% for scaffolded questions, which corresponds to a 4.9 standard deviation effect. The equivalent observation for 236 male students is 9% (5.5 standard deviations). We also observe a correlation between exam performance and A2-level marks for UK students, and that students who receive their school education overseas, in a mixed gender environment, or at an independent school are more likely to receive a first class mark in the exam. These results suggest a mis-match between the problem-solving skills and assessment procedures between school and first year university and will provide key input into the future teaching and assessment of first year undergraduate physics students.

  1. The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.

    PubMed

    Paterson, Louise M; Flechais, Remy S A; Murphy, Anna; Reed, Laurence J; Abbott, Sanja; Boyapati, Venkataramana; Elliott, Rebecca; Erritzoe, David; Ersche, Karen D; Faluyi, Yetunde; Faravelli, Luca; Fernandez-Egea, Emilio; Kalk, Nicola J; Kuchibatla, Shankar S; McGonigle, John; Metastasio, Antonio; Mick, Inge; Nestor, Liam; Orban, Csaba; Passetti, Filippo; Rabiner, Eugenii A; Smith, Dana G; Suckling, John; Tait, Roger; Taylor, Eleanor M; Waldman, Adam D; Robbins, Trevor W; Deakin, J F William; Nutt, David J; Lingford-Hughes, Anne R

    2015-09-01

    Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need for further study of brain mechanisms underpinning relapse circuitry. The Imperial College Cambridge Manchester (ICCAM) platform study is an experimental medicine approach to this problem: using functional magnetic resonance imaging (fMRI) techniques and selective pharmacological tools, it aims to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent, and healthy individuals to inform future drug development. Addiction studies typically involve small samples because of recruitment difficulties and attrition. We established the platform in three centres to assess the feasibility of a multisite approach to address these issues. Pharmacological modulation of reward, impulsivity and emotional reactivity were investigated in a monetary incentive delay task, an inhibitory control task, and an evocative images task, using selective antagonists for µ-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, randomised, crossover design. In two years, 609 scans were performed, with 155 individuals scanned at baseline. Attrition was low and the majority of individuals were sufficiently motivated to complete all five sessions (n=87). We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs.

  2. The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies.

    PubMed

    Bandelt, Hans-Jürgen; Kloss-Brandstätter, Anita; Richards, Martin B; Yao, Yong-Gang; Logan, Ian

    2014-02-01

    Since the determination in 1981 of the sequence of the human mitochondrial DNA (mtDNA) genome, the Cambridge Reference Sequence (CRS), has been used as the reference sequence to annotate mtDNA in molecular anthropology, forensic science and medical genetics. The CRS was eventually upgraded to the revised version (rCRS) in 1999. This reference sequence is a convenient device for recording mtDNA variation, although it has often been misunderstood as a wild-type (WT) or consensus sequence by medical geneticists. Recently, there has been a proposal to replace the rCRS with the so-called Reconstructed Sapiens Reference Sequence (RSRS). Even if it had been estimated accurately, the RSRS would be a cumbersome substitute for the rCRS, as the new proposal fuses--and thus confuses--the two distinct concepts of ancestral lineage and reference point for human mtDNA. Instead, we prefer to maintain the rCRS and to report mtDNA profiles by employing the hitherto predominant circumfix style. Tree diagrams could display mutations by using either the profile notation (in conventional short forms where appropriate) or in a root-upwards way with two suffixes indicating ancestral and derived nucleotides. This would guard against misunderstandings about reporting mtDNA variation. It is therefore neither necessary nor sensible to change the present reference sequence, the rCRS, in any way. The proposed switch to RSRS would inevitably lead to notational chaos, mistakes and misinterpretations.

  3. Comparison of the Diagnostic Accuracy of Neuropsychological Tests in Differentiating Alzheimer's Disease from Mild Cognitive Impairment: Can the Montreal Cognitive Assessment Be Better than the Cambridge Cognitive Examination?

    PubMed Central

    Martinelli, José Eduardo; Cecato, Juliana Francisca; Bartholomeu, Daniel; Montiel, José Maria

    2014-01-01

    Objective Considering the lack of studies on measures that increase the diagnostic distinction between Alzheimer's disease (AD) and mild cognitive impairment (MCI) and on the role of the Cambridge Cognitive Examination (CAMCOG) in this, our study aims to compare the utility of the CAMCOG, Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in helping to differentiate AD from MCI in elderly people with >4 years of schooling. Method A total of 136 elderly subjects – 39 normal controls as well as 52 AD patients and 45 MCI patients treated at the Institute of Geriatrics and Gerontology, Porto Alegre, Brazil – were assessed using the MMSE, CAMCOG, clock drawing test (CDT), verbal fluency test (VF), Geriatric Depression Scale and Pfeffer Functional Activities Questionnaire. Results The results obtained by means of a receiver operating characteristic curve showed that the MoCA is a better screening test for differentiating elderly subjects with AD from those with MCI than the CAMCOG and MMSE as well as other tests such as the CDT and VF. Conclusion The MoCA, more than the CAMCOG and the other tests, was shown to be able to differentiate AD from MCI, although, as Roalf et al. [Alzheimers Dement 2013;9:529-537] pointed out, further studies might lead to measures that will improve this differentiation. PMID:24987399

  4. Face ethnicity and measurement reliability affect face recognition performance in developmental prosopagnosia: evidence from the Cambridge Face Memory Test-Australian.

    PubMed

    McKone, Elinor; Hall, Ashleigh; Pidcock, Madeleine; Palermo, Romina; Wilkinson, Ross B; Rivolta, Davide; Yovel, Galit; Davis, Joshua M; O'Connor, Kirsty B

    2011-03-01

    The Cambridge Face Memory Test (CFMT, Duchaine & Nakayama, 2006) provides a validated format for testing novel face learning and has been a crucial instrument in the diagnosis of developmental prosopagnosia. Yet, some individuals who report everyday face recognition symptoms consistent with prosopagnosia, and are impaired on famous face tasks, perform normally on the CFMT. Possible reasons include measurement error, CFMT assessment of memory only at short delays, and a face set whose ethnicity is matched to only some Caucasian groups. We develop the "CFMT-Australian" (CFMT-Aus), which complements the CFMT-original by using ethnicity better matched to a different European subpopulation. Results confirm reliability (.88) and validity (convergent, divergent using cars, inversion effects). We show that face ethnicity within a race has subtle but clear effects on face processing even in normal participants (includes cross-over interaction for face ethnicity by perceiver country of origin in distinctiveness ratings). We show that CFMT-Aus clarifies diagnosis of prosopagnosia in 6 previously ambiguous cases. In 3 cases, this appears due to the better ethnic match to prosopagnosics. We also show that face memory at short (<3-min), 20-min, and 24-hr delays taps overlapping processes in normal participants. There is some suggestion that a form of prosopagnosia may exist that is long delay only and/or reflects failure to benefit from face repetition.

  5. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2005-02-25

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database.

  6. Genetic Regulation of Development in Sorghum bicolor (IX. The ma3R Allele Disrupts Diurnal Control of Gibberellin Biosynthesis).

    PubMed Central

    Foster, K. R.; Morgan, P. W.

    1995-01-01

    The diurnal regulation of gibberellin (GA) concentrations in Sorghum bicolor was studied in a mutant lacking a light-stable 123-kD phytochrome (ma3Rma3R), wild-type (ma3ma3,Ma3Ma3), and heterozygous (ma3ma3R) cultivars. GAs were determined in shoots of 14-d-old plants by gas chromatography-selected ion-monitoring-mass spectrometry. GA12 levels fluctuated rhythmically in Ma3Ma3, ma3ma3, and,ma3Rma3R; Peak levels occured 3 to 9 h after lights-on. In some experiments, GA53 levels followed a similar pattern. There was no rhythmicity in levels of GA19 and GA8 in any genotype. In ma3ma3 and Ma3Ma3, GA20 levels increased at lights-on, peaked in the afternoon, and decreased to minimum levels in darkness. In ma3Rma3R, peak GA20 levels occured at lights-on, 9 h earlier than in the wild-type genotypes. The pattern for GA1 levels closely followed GA20 levels in all cultivars. One copy of ma3 restored near wild-type regulation of GA20 levels. GA rhythms persisted in 25-d-old ma3ma3 plants. Since absence of the 123-kD phytochrome disrupted diurnal regulation of the GA19 -> GA20 step, the ma3Rma3R genotype may be viewed as being phase shifted in the rhythmic levels of GA20 and GA1 rather than as simply overproducing them. PMID:12228478

  7. Biochemical Characterization of Rous Sarcoma Virus MA Protein Interaction with Membranes

    PubMed Central

    Dalton, Amanda K.; Murray, Paul S.; Murray, Diana; Vogt, Volker M.

    2005-01-01

    The MA domain of retroviral Gag proteins mediates association with the host cell membrane during assembly. The biochemical nature of this interaction is not well understood. We have used an in vitro flotation assay to directly measure Rous sarcoma virus (RSV) MA-membrane interaction in the absence of host cell factors. The association of purified MA and MA-containing proteins with liposomes of defined composition was electrostatic in nature and depended upon the presence of a biologically relevant concentration of negatively charged lipids. A mutant MA protein known to be unable to promote Gag membrane association and budding in vivo failed to bind to liposomes. These results were supported by computational modeling. The intrinsic affinity of RSV MA for negatively charged membranes appears insufficient to promote efficient plasma membrane binding during assembly. However, an artificially dimerized form of MA bound to liposomes by at least an order of magnitude more tightly than monomeric MA. This result suggests that the clustering of MA domains, via Gag-Gag interactions during virus assembly, drives membrane association in vivo. PMID:15858007

  8. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization....

  9. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Payments to Medicare Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans....

  10. 42 CFR 422.512 - Termination of contract by the MA organization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.512 Termination of contract by the MA organization....

  11. Integrated EPA Science for Decision-Making: Lawrence, MA Water Strategy

    EPA Science Inventory

    Powerpoint presentation on the Lawrence MA Making a Visible Difference in Communities project’s comprehensive water quality strategy, demonstrating a systems approach applying integrated EPA science

  12. SDSS-IV MaNGA: Data Products, Quality, and Initial Public Release

    NASA Astrophysics Data System (ADS)

    Law, David R.; Cherinka, Brian; MaNGA Team

    2016-01-01

    As a spectroscopic imaging survey, MaNGA presents a host of technical challenges ranging from spectrophotometic calibration to image reconstruction. I will present an overview of the MaNGA data reduction pipeline (DRP) and the algorithms used to process the MaNGA data. Additionally, I will describe the format and quality of the MaNGA data products, and the means by which the first year of survey data will be made publicly available in SDSS Data Release 13 (DR-13).

  13. National Program for Inspection of Non-Federal Dams. Ames Pond Dam (MA 01006) Dike A (MA 01296) Merrimack River Basin, Tewksbury, Massachusetts. Phase I Inspection Report.

    DTIC Science & Technology

    1980-12-01

    Massachusetts 02146 . Copies of this report will be made available to the public, upon request to this office, under the Freedom of Information Act...Ownership. Ames Pond Dam is owned by the Beacon Mortgage, Inc. 1425 Beacon St., Brookline, MA 02146 . Tele: 617-232-7850. An Engineering Report shown...Brookline, MA 02146 . Tele: 617-232-7850. g. Purpose of Dam. The dam impounds a pond used for recreational purposes. 3

  14. Induction of neuronal cell death by paraneoplastic Ma1 antigen.

    PubMed

    Chen, Huai-Lu; D'Mello, Santosh R

    2010-12-01

    Paraneoplastic Ma1 (PNMA1) is a member of a family of proteins involved in an autoimmune disorder called paraneoplastic neurological syndrome. Although it is widely expressed in brain, nothing is known about the function of PNMA1 in neurons. We find that PNMA1 expression is highest in the perinatal brain, a period during which developmentally regulated neuronal death occurs. PNMA1 expression increases in cerebellar granule neurons (CGNs) induced to die by low potassium (LK) and in cortical neurons following homocysteic acid (HCA) treament. Elevated PNMA1 expression is also observed in the degenerating striatum in two separate mouse models of Huntington's disease, the R6/2 transgenic model and the 3-nitropropionic acid-induced chemical model. Suppression of endogenous PNMA1 expression inhibits LK-induced neuronal apoptosis. Ectopic expression of PNMA1 promotes apoptosis even in medium containing high potassium, a condition that normally ensures survival of CGNs. Deletion of the N-terminal half of the PNMA1 protein abrogates its apoptotic activity, whereas deletion of the C-terminal half renders the protein more toxic. Within the N-terminal half, the ability to induce neuronal death depends on the presence of a BH3-like domain. In addition to being necessary for apoptosis, the BH3-like domain is necessary for self-association of PNMA1. Apoptosis by PNMA1 expression is inhibited by overexpression of Bcl2, suggesting that PNMA1-induced neuronal death may depend on the binding of a proapoptotic member of the Bcl2 family to the BH3 domain. Taken together, our results suggest that PNMA1 is a proapoptotic protein in neurons, elevated expression of which may contribute to neurodegenerative disorders.

  15. M&A needn't be a loser's game.

    PubMed

    Selden, Larry; Colvin, Geoffrey

    2003-06-01

    Three out of four acquisitions fail; they destroy wealth for the buyer's shareholders, who end up worse off than they would have been had the deal not been done. But it doesn't have to be that way, argue the authors. In evaluating acquisitions, companies must look beyond the lure of profits the income statement promises and examine the balance sheet, where the company keeps track of capital. It's ignoring the balance sheet that causes so many acquisitions to destroy shareholders' wealth. Unfortunately, most executives focus only on sales and profits going up, never realizing that they've put in motion a plan to destroy their company's true profitability--its return on invested capital. M&A, like other aspects of running a company, works best when seen as a way to create shareholder value through customers. Some deals are sought to help create better value propositions for the business or to better execute current strategies--or to block competitors from doing these things. But most deals are about customers and should start with an analysis of customer profitability. Some customers are deliciously profitable; others are dismal money losers. The better an acquirer understands the profitability of its own customers, the better positioned it will be to perform such analyses on other companies. In this article, the authors show that customer profitability varies far more dramatically than most managers suspect. They also describe how to measure the profitability of customers. By understanding the economics of customer profitability, companies can avoid making deals that hurt their shareholders, they can identify surprising deals that do create wealth, and they can salvage deals that would otherwise be losers.

  16. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2009-08-28

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document.

  17. 33 CFR 80.145 - Race Point, MA, to Watch Hill, RI.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Race Point, MA, to Watch Hill, RI. 80.145 Section 80.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.145 Race Point, MA, to Watch...

  18. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency...

  19. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War...

  20. Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

    NASA Astrophysics Data System (ADS)

    Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

    M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

  1. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... travel and lodging where applicable); and (2) Reasonable compensation to the non-hospital site for... chapter. (3) There is a written agreement between the MA organization and the non-hospital site that... reasonable compensation to the non-hospital site for teaching activities. (c) An MA organization's...

  2. 42 CFR 422.50 - Eligibility to elect an MA plan.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... local and MA regional plans, as defined in § 422.2 unless specifically noted otherwise. (a) An... organization's contract for the plan or discontinued the plan in the area in which the individual resides, is eligible to elect another MA plan. If the plan so elected is later terminated or discontinued in the...

  3. Exploring African Aridification and Wet/dry Cycles Over the Last 3 MA

    NASA Astrophysics Data System (ADS)

    Meyers, C.; Tierney, J. E.; DeMenocal, P. B.

    2011-12-01

    Marine sediment records document a gradual increase in aeolian dust supply from Africa over the last 3 Ma in the Atlantic, Gulf of Aden, and Mediterranean (Larrasoaña et al., 2003, deMenocal 2004), with 'steps' in period and amplitude at ~2.8 Ma, ~1.7 Ma, and ~1.0 Ma. However, Mediterranean sapropel sequences document regular, precession-paced wet/dry cycles from changes in the strength of the African monsoon and Nile runoff since at least the Miocene (Rossignol-Strick, 1985, Krijgsman et al., 1995, Lourens et al., 1996). The influence of long-term drying trends in Africa on the movements and strength of the African monsoon over the late Pliocene and Pleistocene is not understood. We have constructed a biomarker-based African climate record by analyzing concentrations and δ D from long-chain, saturated fatty acid methyl esters (FAMEs) in eastern Mediterranean ODP Site 967 sediments from 2.8 - 3.1 Ma and 1.6 - 1.8 Ma. Long-chain fatty acids are produced in the leaf waxes of terrestrial plants (Eglinton and Hamilton, 1967) and are transported to marine sediments via aeolian and fluvial action. Sapropel sediments corresponding with precession minima and enhanced Nile River runoff (Rossignol-Strick, 1985) contain much higher concentrations of FAMEs than carbonate-rich sediments. Comparisons of the two intervals will be presented to illustrate changes in monsoon strength from 3 Ma to 1.6 Ma.

  4. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    ERIC Educational Resources Information Center

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  5. 42 CFR 422.62 - Election of coverage under an MA plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Election of coverage under an MA plan. 422.62... SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Eligibility, Election, and Enrollment § 422.62 Election of coverage under an MA plan. (a) General: Coverage election periods—(1)...

  6. 33 CFR 165.T01-0542 - Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA. 165.T01-0542 Section 165.T01-0542 Navigation and Navigable Waters... Guard District § 165.T01-0542 Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA....

  7. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... § 422.54. (2) An individual enrolled in an MA plan that becomes an MA-PD plan on January 1, 2006, will...-PD plan offered by the same organization as of January 1, 2006. (4) An individual who has elected an... form with the organization or through other mechanisms as determined by CMS. (b)...

  8. 42 CFR 422.66 - Coordination of enrollment and disenrollment through MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 422.54. (2) An individual enrolled in an MA plan that becomes an MA-PD plan on January 1, 2006, will...-PD plan offered by the same organization as of January 1, 2006. (4) An individual who has elected an... form with the organization or through other mechanisms as determined by CMS. (b)...

  9. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Special rules for beneficiaries enrolled in MA MSA... Advantage Organizations § 422.314 Special rules for beneficiaries enrolled in MA MSA plans. (a) Establishment and designation of medical savings account (MSA). A beneficiary who elects coverage under an...

  10. Liberal Arts in China's Modern Universities: Lessons from the Great Catholic Educator and Statesman, Ma Xiangbo

    ERIC Educational Resources Information Center

    Jiang, You Guo

    2012-01-01

    Ma Xiangbo was born in 1840 and became a pioneer of educational reform during the republican period. He was responsible for introducing the idea that science and humanities should be valued equally in liberal arts education, a concept that became key to the model of university education. Ma's view of education combined Western humanism and science…

  11. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency...

  12. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War...

  13. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War...

  14. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from MARAD's underwriting agent or MARAD....

  15. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency...

  16. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308. The Standard Form of Surety Bond A, Form MA-308, which may be obtained from the American War Risk Agency...

  17. 46 CFR 308.529 - Surety Bond B, Form MA-309.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond B, Form MA-309. 308.529 Section 308.529 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309....

  18. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War...

  19. 46 CFR 308.528 - Surety Bond A, Form MA-308.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Surety Bond A, Form MA-308. 308.528 Section 308.528 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.528 Surety Bond A, Form MA-308....

  20. Lessons Learned from M.A. Candidates Pursuing National Board Certification.

    ERIC Educational Resources Information Center

    Unrau, Norman J.

    2003-01-01

    Presents lessons learned by following M.A. candidates who were supported by California State University, Los Angeles, as they pursued National Board for Professional Teaching Standards (NBPTS) certification. Discusses the introduction of NBPTS certification to M.A. candidates, launching certification projects, and what NBPTS certification…

  1. Specific Features of Executive Dysfunction in Alzheimer-Type Mild Dementia Based on Computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) Test Results

    PubMed Central

    Kuzmickienė, Jurgita; Kaubrys, Gintaras

    2016-01-01

    Background The primary manifestation of Alzheimer’s disease (AD) is decline in memory. Dysexecutive symptoms have tremendous impact on functional activities and quality of life. Data regarding frontal-executive dysfunction in mild AD are controversial. The aim of this study was to assess the presence and specific features of executive dysfunction in mild AD based on Cambridge Neuropsychological Test Automated Battery (CANTAB) results. Material/Methods Fifty newly diagnosed, treatment-naïve, mild, late-onset AD patients (MMSE ≥20, AD group) and 25 control subjects (CG group) were recruited in this prospective, cross-sectional study. The CANTAB tests CRT, SOC, PAL, SWM were used for in-depth cognitive assessment. Comparisons were performed using the t test or Mann--Whitney U test, as appropriate. Correlations were evaluated by Pearson r or Spearman R. Statistical significance was set at p<0.05. Results AD and CG groups did not differ according to age, education, gender, or depression. Few differences were found between groups in the SOC test for performance measures: Mean moves (minimum 3 moves): AD (Rank Sum=2227), CG (Rank Sum=623), p<0.001. However, all SOC test time measures differed significantly between groups: SOC Mean subsequent thinking time (4 moves): AD (Rank Sum=2406), CG (Rank Sum=444), p<0.001. Correlations were weak between executive function (SOC) and episodic/working memory (PAL, SWM) (R=0.01–0.38) or attention/psychomotor speed (CRT) (R=0.02–0.37). Conclusions Frontal-executive functions are impaired in mild AD patients. Executive dysfunction is highly prominent in time measures, but minimal in performance measures. Executive disorders do not correlate with a decline in episodic and working memory or psychomotor speed in mild AD. PMID:27717954

  2. The Cambridge Companion to Dewey. Cambridge Companions to Philosophy

    ERIC Educational Resources Information Center

    Cochran, Molly

    2010-01-01

    John Dewey (1859-1952) was a major figure of the American cultural and intellectual landscape in the first half of the twentieth century. While not the originator of American pragmatism, he was instrumental to its articulation as a philosophy and the spread of its influence beyond philosophy to other disciplines. His prolific writings encompass…

  3. Spin-Axis Alignment of Koronis Family Asteroids

    NASA Astrophysics Data System (ADS)

    Slivan, Stephen Michael

    1995-01-01

    reason for apparent clustering of the spin axis longitudes is not clear, but may mean differences in their rates of forced solar precession are small. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  4. Investigation of Prolific Sheep from UK and Ireland for Evidence on Origin of the Mutations in BMP15 (FecXG, FecXB) and GDF9 (FecGH) in Belclare and Cambridge Sheep

    PubMed Central

    Mullen, Michael P.; Hanrahan, James P.; Howard, Dawn J.

    2013-01-01

    This paper concerns the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecXG and FecXB) and the third (FecGH) in GDF9. All three mutations segregate in Belclare sheep while one, FecXB, has not been found in the Cambridge. Both Belclare and Cambridge breeds are relatively recently developed composites that have common ancestry through the use of genetic material from the Finnish Landrace and Lleyn breeds. The development of both composites also involved major contributions from exceptionally prolific ewes screened from flocks in Ireland (Belclare) and Britain (Cambridge) during the 1960s. The objective of the current study was to establish the likely origin of the mutations (FecXG, FecXB and FecGH) through analysis of DNA from Finnish Landrace and Lleyn sheep, and Galway and Texel breeds which contributed to the development of the Belclare breed. Ewes with exceptionally high prolificacy (hyper-prolific ewes) in current flocks on Irish farms were identified to simulate the screening of ewes from Irish flocks in the 1960s. DNA was obtained from: prolific ewes in extant flocks of Lleyn sheep (n = 44) on the Lleyn peninsula in Wales; hyper-prolific ewes (n = 41); prolific Galway (n = 41) ewes; Finnish Landrace (n = 124) and Texel (n = 19) ewes. The FecXG mutation was identified in Lleyn but not in Finnish Landrace, Galway or Texel sheep; FecXB was only found among the hyper-prolific ewes. The FecGH mutation was identified in the sample of Lleyn sheep. It was concluded from these findings that the Lleyn breed was the most likely source of the FecXG and FecGH mutations in Belclare and Cambridge sheep and that the FecXB mutation came from the High Fertility line that was developed using prolific ewes selected from commercial flocks in Ireland in the 1960′s and subsequently used in the genesis of the Belclare. PMID:23301039

  5. Preserved History of Global Mean Spreading Rate: 83 Ma to Present

    NASA Astrophysics Data System (ADS)

    Rowan, Christopher J.; Rowley, David B.

    2016-07-01

    Using an up-to-date global plate rotation model, applied to the end points of preserved major spreading ridge isochrons, we have calculated the explicitly reconstructable length-weighted mean global half-spreading rate, ridge length, and area production as a function of time since the end of the Cretaceous Normal Superchron at 83.0 Ma. Our calculations integrate uncertainties in rotation parameters and chron boundary ages with the partial sampling uncertainties arising from progressive subduction of older oceanic lithosphere and its preserved spreading record. This record of directly reconstructable oceanic ridge production provides a well-constrained baseline that can be compared to reconstructions that include the largely unconstrained extrapolated histories of entirely subducted oceanic plates. The directly reconstructable global mean half-spreading rate has not varied by more than ± 15% about an average rate of 28.4 ± 4.6 mm/a since 83 Ma. No long-term secular trend is evident: a maximum global mean half-rate of 32 ± 6 mm/a occurred from 33.1 Ma to about 25.8 Ma, with minima of 26 ± 5 mm/a between about 56 Ma and 40.2 Ma, and 24 ± 1 mm/a since 3.2 Ma. Only this most recent interval has a rate that differs significantly (at ± 2σ) from the long-term mean. The global, reconstructable ridge length at 56 Ma decreases by less than 15% relative to the modern ridge system; by 83 Ma it has decreased by 38%. These relatively high preserved ridge fractions mean that the estimated uncertainty due to partial sampling stays roughly equivalent to the estimated rotation model uncertainties, allowing long-term spreading rate variations of > 20% since the Late Cretaceous to be ruled out. In contrast, prior to 83 Ma too little oceanic lithosphere is preserved to reliably reconstruct global spreading rates.

  6. NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation.

    PubMed

    Gallini, Sara; Carminati, Manuel; De Mattia, Fabiola; Pirovano, Laura; Martini, Emanuele; Oldani, Amanda; Asteriti, Italia Anna; Guarguaglini, Giulia; Mapelli, Marina

    2016-02-22

    Spindle positioning is essential for tissue morphogenesis and homeostasis. The signaling network synchronizing spindle placement with mitotic progression relies on timely recruitment at the cell cortex of NuMA:LGN:Gαi complexes, in which NuMA acts as a receptor for the microtubule motor Dynein. To study the implication of Aurora-A in spindle orientation, we developed protocols for the partial inhibition of its activity. Under these conditions, in metaphase NuMA and Dynein accumulate abnormally at the spindle poles and do not reach the cortex, while the cortical distribution of LGN remains unperturbed. FRAP experiments revealed that Aurora-A governs the dynamic exchange between the cytoplasmic and the spindle pole-localized pools of NuMA. We show that Aurora-A phosphorylates directly the C terminus of NuMA on three Ser residues, of which Ser1969 determines the dynamic behavior and the spindle orientation functions of NuMA. Most interestingly, we identify a new microtubule-binding domain of NuMA, which does not overlap with the LGN-binding motif. Our study demonstrates that in metaphase the direct phosphorylation of NuMA by Aurora-A controls its cortical enrichment, and that this is the major event underlying the spindle orientation functions of Aurora-A in transformed and non-transformed cells in culture. Phosphorylation of NuMA by Aurora-A does not affect its affinity for microtubules or for LGN but rather determines the mobility of the protein at the spindle poles. The finding that NuMA can associate concomitantly with LGN and microtubules suggests that its microtubule-binding activity contributes to anchor Dynein-loaded microtubule +TIPs at cortical sites with LGN.

  7. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2007-03-12

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Revision Log: Rev. 0 (2/25/2005) Major revision and expansion. Rev. 0.1 (3/12/2007) Minor

  8. Anthropogenic Influences on Estuarine Sedimentation in Salem Sound, MA

    NASA Astrophysics Data System (ADS)

    Kristiansen, E. R.; Hubeny, J. B.; Zhu, J.; Olsen, C. R.; Warren, B.

    2010-12-01

    The Salem Sound watershed (MA) historically has been a region of significant industrial activity. Two specific point sources for pollution in the region are the South Essex Sewerage District (SESD) wastewater treatment facility, and the Salem Harbor Power Station, a coal-burning power plant. This study tests the hypothesis that human impact on Salem Sound is preserved in the sediment record. A sediment core was taken near the location of the SESD outfall. This core was analyzed for content of organic matter via loss on ignition (LOI), as well as magnetic susceptibility. An age model was constructed using 137Cs and 210Pb. Below 31 cm (mid-nineteenth century), the core contains mean background values of 2.7% LOI and values increase above this depth. At 21cm, a rapid increase in organic matter concentration from 6.6% to 11.8% is observed. This depth corresponds to ~1905 which is contemporaneous with construction of the outfall pipe discharging raw wastewater. At a depth of 7 cm (mid 1970s), LOI values decrease from 11.7% to 9.3%. This shift is likely attributed to SESD beginning primary treatment in 1977. LOI values continue to drop at 2cm (late 1990s), from 7.8% to 6.3%, and remain at 6.1% to the modern surface, likely a result of SESD upgrading to secondary treatment in 1998. Magnetic susceptibility also shows variability down core that is likely attributed to human impact. At a depth of approximately 20cm susceptibility values start increasing from 4.2 SI units until they reach a peak at 15cm (8.8 SI units). This increase can be attributed to the industrial revolution and increased industrial activity in the area. A decrease in susceptibility is observed at 15cm to 11cm (5.6 SI units) that may be attributed to the Great Depression and less fossil fuels being burned due to the economic situation. At approximately 10cm and 8.0 SI units, an increasing trend is first observed. This trend continues up to the modern surface where it eventually reaches 19.9 SI units. This

  9. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2011-04-04

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  10. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2010-04-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  11. Mercury Cycling in Salt Marsh Pond Ecosystems: Cape Cod, MA

    NASA Astrophysics Data System (ADS)

    Ganguli, P. M.; Gonneea, M. E.; Lamborg, C. H.; Kroeger, K. D.; Swarr, G.; Vadman, K. J.; Baldwin, S.; Brooks, T. W.; Green, A.

    2014-12-01

    We are measuring total mercury (HgT) and monomethylmercury (CH3Hg+ or MMHg) in pore water, surface water, and sediment cores from two salt marsh pond systems on the south shore of Cape Cod, MA to characterize the distribution of mercury species and to identify features that influence mercury speciation and transport. Sage Lot Pond is relatively undisturbed and has low nitrogen loading (12 kg ha-1 y-1). It is part of the Waquoit Bay National Estuarine Reserve and is surrounded by undeveloped wooded uplands. In contrast, Great Pond is highly impacted. Nitrogen loading to the site is elevated (600 kg ha-1 y-1) and the marsh is adjacent to a large residential area. In both systems, a 1 to 2 m organic-rich peat layer overlies the permeable sand aquifer. Groundwater in this region is typically oxic, where pore water within salt marsh peat is suboxic to anoxic. We hypothesize that redox gradients at the transition from the root zone to peat and at the peat-sand interface may provide habitat for MMHg-producing anaerobic bacteria. Preliminary results from a 2-m nearshore depth profile at Sage Lot Pond indicate HgT in groundwater within the sand aquifer occurred primarily in the > 0.2 μm fraction, with unfiltered concentrations exceeding 100 pM. Filtered (< 0.2 μm) HgT in groundwater was substantially lower (~ 5 pM). In contrast, HgT concentrations in filtered and unfiltered pore water within the peat layer were similar and ranged from about 2 to 3 pM. Complexation between mercury and dissolved organic carbon may account for the elevated fraction of filtered HgT in peat pore water. Although MMHg in both groundwater and pore water remained around 1 pM throughout our depth profile, we observed an increase in sediment MMHg (0.3 to 1.6 μg/kg) at the peat-sand interface. MMHg comprised ~50% of the HgT concentration in pore water suggesting mercury in the salt marsh peat is biologically available.

  12. Water-quality conditions, and constituent loads and yields in the Cambridge drinking-water source area, Massachusetts, water years 2005–07

    USGS Publications Warehouse

    Smith, Kirk P.

    2013-01-01

    The source water area for the drinking-water supply of the city of Cambridge, Massachusetts, encompasses major transportation corridors, as well as large areas of light industrial, commercial, and residential land use. Because of ongoing development in the drinking-water source area, the Cambridge water supply has the potential to be affected by a wide variety of contaminants. The U.S. Geological Survey (USGS) has monitored surface-water quality in the Hobbs Brook and Stony Brook Basins, which compose the drinking-water source area, since 1997 (water year 1997) through continuous monitoring and discrete sample collection and, since 2004, through systematic collection of streamwater samples during base-flow and stormflow conditions at five primary sampling stations in the drinking-water source area. Four primary sampling stations are on small tributaries in the Hobbs Brook and Stony Brook Basins; the fifth primary sampling station is on the main stem of Stony Brook and drains about 93 percent of the Cambridge drinking-water source area. Water samples also were collected at six secondary sampling stations, including Fresh Pond Reservoir, the final storage reservoir for the raw water supply. Storm runoff and base-flow concentrations of calcium (Ca), chloride (Cl), sodium (Na), and sulfate (SO4) were estimated from continuous records of streamflow and specific conductance for six monitoring stations, which include the five primary sampling stations. These data were used to characterize current water-quality conditions, estimate loads and yields, and describe trends in Cl and Na in the tributaries and main-stem streams in the Hobbs Brook and Stony Brook Basins. These data also were used to describe how streamwater quality is affected by various watershed characteristics and provide information to guide future watershed management. Water samples were analyzed for physical properties and concentrations of Ca, Cl, Na, and SO4, total nitrogen (TN), total phosphorus (TP

  13. Change of tectono-stratigraphic regime in the Australian plate during the 99 Ma (mid-Cretaceous) and 43 Ma (mid-Eocene) swerves of the Pacific

    NASA Astrophysics Data System (ADS)

    Veevers, J. J.

    2000-01-01

    The clockwise bend at 99 Ma (mid-Cretaceous) in linear volcanic chains in the tropical Pacific coincides with a change from pre-99 Ma head-on Chilean-type subduction of the Pacific plate beneath eastern Gondwana to 99 43 Ma sinistral oblique Mariana-type subduction and strike-slip breakup by simple sea-floor spreading between Australia and Antarctica and by backarc spreading in the southwest Pacific. The 99 Ma breakup of Australia from Antarctica is documented by a mid-Cretaceous unconformity. This tectono-stratigraphic change founded modern Australia, with a mountain chain along an upper plate margin in the east and lowlands on the lower plate margin in the south. The counterclockwise bend at 43 Ma (mid-Eocene)—the Emperor-Hawaiian bend—coincides with the onset of structure in the Challenger Rift of New Zealand, the Eromanga-Cooper basin of central Australia, and the oil-shale grabens of coastal Queensland.

  14. Diversity in early crustal evolution: 4100 Ma zircons in the Cathaysia Block of southern China.

    PubMed

    Xing, Guang-Fu; Wang, Xiao-Lei; Wan, Yusheng; Chen, Zhi-Hong; Jiang, Yang; Kitajima, Kouki; Ushikubo, Takayuki; Gopon, Phillip

    2014-06-03

    Zircons are crucial to understanding the first 500 Myr of crustal evolution of Earth. Very few zircons of this age (>4050 Ma) have been found other than from a ~300 km diameter domain of the Yilgarn Craton, Western Australia. Here we report SIMS U-Pb and O isotope ratios and trace element analyses for two ~4100 Ma detrital zircons from a Paleozoic quartzite at the Longquan area of the Cathaysia Block. One zircon ((207)Pb/(206)Pb age of 4127 ± 4 Ma) shows normal oscillatory zonation and constant oxygen isotope ratios (δ(18)O = 5.8 to 6.0‰). The other zircon grain has a ~4100 Ma magmatic core surrounded by a ~4070 Ma metamorphic mantle. The magmatic core has elevated δ(18)O (7.2 ± 0.2‰), high titanium concentration (53 ± 3.4 ppm) and a positive cerium anomaly, yielding anomalously high calculated oxygen fugacity (FMQ + 5) and a high crystallization temperature (910°C). These results are unique among Hadean zircons and suggest a granitoid source generated from dry remelting of partly oxidizing supracrustal sediments altered by surface waters. The ~4100 Ma dry melting and subsequent ~4070 Ma metamorphism provide new evidence for the diversity of the Earth's earliest crust.

  15. Diversity in early crustal evolution: 4100 Ma zircons in the Cathaysia Block of southern China

    NASA Astrophysics Data System (ADS)

    Xing, Guang-Fu; Wang, Xiao-Lei; Wan, Yusheng; Chen, Zhi-Hong; Jiang, Yang; Kitajima, Kouki; Ushikubo, Takayuki; Gopon, Phillip

    2014-06-01

    Zircons are crucial to understanding the first 500 Myr of crustal evolution of Earth. Very few zircons of this age (>4050 Ma) have been found other than from a ~300 km diameter domain of the Yilgarn Craton, Western Australia. Here we report SIMS U-Pb and O isotope ratios and trace element analyses for two ~4100 Ma detrital zircons from a Paleozoic quartzite at the Longquan area of the Cathaysia Block. One zircon (207Pb/206Pb age of 4127 +/- 4 Ma) shows normal oscillatory zonation and constant oxygen isotope ratios (δ18O = 5.8 to 6.0‰). The other zircon grain has a ~4100 Ma magmatic core surrounded by a ~4070 Ma metamorphic mantle. The magmatic core has elevated δ18O (7.2 +/- 0.2‰), high titanium concentration (53 +/- 3.4 ppm) and a positive cerium anomaly, yielding anomalously high calculated oxygen fugacity (FMQ + 5) and a high crystallization temperature (910°C). These results are unique among Hadean zircons and suggest a granitoid source generated from dry remelting of partly oxidizing supracrustal sediments altered by surface waters. The ~4100 Ma dry melting and subsequent ~4070 Ma metamorphism provide new evidence for the diversity of the Earth's earliest crust.

  16. Antioxidative effects in vivo and colonization of Lactobacillus plantarum MA2 in the murine intestinal tract.

    PubMed

    Tang, Wei; Xing, Zhuqing; Hu, Wei; Li, Chao; Wang, Jinju; Wang, Yanping

    2016-08-01

    Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibet kefir grains, which possess several excellent properties and functions. We previously demonstrated the antioxidant activities of this bacterium in vitro. However, the maintenance and survival of L. plantarum MA2 inside the murine intestinal tract, where it exerts its probiotic properties, and whether its effects are elicited directly on the host remain unknown. Therefore, this study investigated the mechanisms of L. plantarum MA2 in aging mice following D-galactose administration. The levels of malondialdehyde decreased significantly in the L. plantarum MA2 groups after oral ingestion compared to the D-galactose model group, and total antioxidant capacity and glutathione peroxidase and superoxide dismutase activities increased significantly in the serum and liver. We combined fluorescein isothiocyanate labeling and green fluorescent protein expression to dynamically monitor the colonization and distribution of L. plantarum MA2 in the murine intestinal tract. The results indicated that L. plantarum MA2 was detected in the ileum, colon, and feces after single and continuous oral administration at day 21 and was maintained at 10(4)-10(5) CFU/g. These results suggest that L. plantarum MA2 colonizes and survives in the murine intestinal tract to exert its antioxidative effects.

  17. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

    PubMed Central

    Yue, Kan; Santiago, Grissel Trujillo-de; Alvarez, Mario Moisés; Tamayol, Ali; Annabi, Nasim; Khademhosseini, Ali

    2015-01-01

    Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics. Three dimensional (3D) GelMA hydrogels closely resemble some essential properties of native extracellular matrix (ECM) due to the presence of cell-attaching and matrix metalloproteinase responsive peptide motifs, which allow cells to proliferate and spread in GelMA-based scaffolds. GelMA is also versatile from a processing perspective. It crosslinks when exposed to light irradiation to form hydrogels with tunable mechanical properties which mimic the native ECM. It can also be microfabricated using different methodologies including micromolding, photomasking, bioprinting, self-assembly, and microfluidic techniques to generate constructs with controlled architectures. Hybrid hydrogel systems can also be formed by mixing GelMA with nanoparticles such as carbon nanotubes and graphene oxide, and other polymers to form networks with desired combined properties and characteristics for specific biological applications. Recent research has demonstrated the proficiency of GelMA-based hydrogels in a wide range of applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others. Other applications of GelMA hydrogels, besides tissue engineering, include fundamental single-single cell research, cell signaling, drug and gene delivery, and bio-sensing. PMID:26414409

  18. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    SciTech Connect

    Rathbone, Bruce A.

    2010-01-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Maintenance and distribution of controlled hard copies of the

  19. Preserved history of global mean spreading rate: 83 Ma to present

    NASA Astrophysics Data System (ADS)

    Rowan, Christopher J.; Rowley, David B.

    2017-02-01

    Using an up-to-date global plate rotation model, applied to the endpoints of preserved major spreading ridge isochrons, we have calculated the explicitly reconstructable length-weighted mean global half-spreading rate (HSR), ridge length and area production as a function of time since the end of the Cretaceous Normal Superchron at 83.0 Ma. Our calculations integrate uncertainties in rotation parameters and chron boundary ages with the partial sampling uncertainties arising from progressive subduction of older oceanic lithosphere and its preserved spreading record. This record of directly reconstructable oceanic ridge production provides a well-constrained baseline that can be compared to reconstructions that include the largely unconstrained extrapolated histories of entirely subducted oceanic plates. The directly reconstructable global mean HSR has not varied by more than ±15 per cent about an average rate of 28.4 ± 4.6 mm a-1 since 83 Ma. No long-term secular trend is evident: a maximum global mean half-rate of 32 ± 6 mm a-1 occurred from 33.1 Ma to about 25.8 Ma, with minima of 26 ± 5 mm a-1 between about 56 and 40.2 Ma, and 24 ± 1 mm a-1 since 3.2 Ma. Only this most recent interval has a rate that differs significantly (at ±2σ) from the long-term mean. The global, reconstructable ridge length at 56 Ma decreases by less than 15 per cent relative to the modern ridge system; by 83 Ma it has decreased by 38 per cent. These relatively high preserved ridge fractions mean that the estimated uncertainty due to partial sampling stays roughly equivalent to the estimated rotation model uncertainties, allowing long-term spreading rate variations of >20 per cent since the Late Cretaceous to be ruled out. In contrast, prior to 83 Ma too little oceanic lithosphere is preserved to reliably reconstruct global spreading rates.

  20. Volcano-tectonic evolution of the Castle Mountains: 22 to 14 MA

    SciTech Connect

    Capps, R.C. . Dept. of Geology)

    1993-04-01

    The alkali-calcic Castle Mountains Volcanic rocks (CMV) are host to major gold mineralization. They are located about 100 km south of Las Vegas, Nevada and are on the boundary between the Basin and Range Province and Colorado River extensional corridor (35[degree]18 minutes 45 seconds N, 115[degree]05 minutes 10 seconds W). New data show the following chronology. 22 Ma. A regional rhyolite ash-flow tuff, the Castle Mountain Tuff member, was deposited on a Proterozoic-Paleozoic basement of low relief. <22 Ma - > 17 Ma. Normal faulting (N30--60[degree]W, 60--65[degree]NE) formed half-grabens. Latite and basalt flows, minor ash-flow tuffs, lahars and sediments (Jacks Well member - JW) were deposited unconformably. JW magmas are enriched in light REE compared to the younger CMV. <17 Ma to 15.5 Ma. Oxidizing upper portions (796 C) of a shallowly emplaced silicic melt erupted to form the high-silica rhyolite dome complexes and intrusives (Linder Peak member - LP) of the NNE-striking Castle Mountains. NW-striking transverse structures caused discontinuities in strike direction of the subvolcanic intrusive and domes and helped form a synvolcanic depression. During a hiatus in volcanism, early Hart Peak member (HP) sediments were deposited marginal to the Castle Mountains. Major gold mineralization and widespread hydrothermal alteration occurred at about 15.5 Ma. 16 Ma to 14 Ma. Early HP volcaniclastic sediments, rhyolite pyroclastic-surge tuff, and basaltic flows, were deposited during late hydrothermal alteration and then fractured and displaced by NNE-striking normal faults, especially in the eastern and northeastern CMV. < 14 Ma. Tectonically significant flat-lying boulder conglomerate and unconformably overlying, largely andesitic flows fill depressions in the Castle Mountains and the Piute Range to the east.

  1. Reconstructing the temperature and salinity of the Mediterranean Sea through the Late Miocene (13 Ma - 6 Ma) prior to the Messinian Salinity Crisis

    NASA Astrophysics Data System (ADS)

    Tzanova, Alexandrina; Herbert, Timothy; Peterson, Laura

    2014-05-01

    We present a unique, alkenone-based record of sea surface temperatures spanning 13 Ma to 6 Ma from the uplifted, pelagic, Mediterranean sequence at Monte dei Corvi. The thick salt layers resulting from the isolation of the Mediterranean have so far been an obstacle to conventional drilling in obtaining a high-resolution, continuous record of the basin's conditions prior to ~6 Ma. This is especially important when reconstructing the climate conditions that preceded and contributed to the Messinian Salinity Crisis. Uplifted sections allow access to this otherwise unresolved time period. Planktonic d18O records from uplifted marine sections exist; however, they are hampered by the lack of independent temperature reconstruction in order to detangle the competing influence of both temperature and salinity on such data. Using alkenone paleothermometry we show that the Late Miocene Mediterranean Sea was notably warmer than present with SSTs equivalent and even higher than the warmest parts of the modern ocean. Between ~ 12.9 Ma to ~8.1 Ma temperatures hovered close to 28oC and possibly even higher. At ~8.1 Ma, concurrent with notable changes in the vegetation pattern of the area as well as globally, sea surface temperatures show a distinct cooling trend punctuated with a cold episode at ~7 Ma which coincides with the first appearance of desert conditions in the Sahara. The cooling trend continues up to the Messinian Salinity Crisis at which point marine sedimentation was interrupted at the site. Our dataset contains four high-resolution windows where we examine the precession scale SST changes that contributed to sapropel formation and comparing them with the regime established for the Plio-Pleistocene. The reconstructed sea surface temperatures allow us to reconstruct the paleo-salinity of the Mediterranean leading up to the Messinian Salinity Crisis. The uncorrected the published d18O planktonic records show a sharp enrichment at ~7.5 Ma. Once corrected for temperature

  2. MaRIE: Probing Dynamic Processes in Soft Materials Using Advanced Light Sources

    SciTech Connect

    Sykora, Milan; Kober, Edward Martin

    2016-02-16

    Los Alamos National Laboratory has developed a concept for a new research facility, MaRIE: Matter-Radiation Interactions in Extremes. The key motivation for MaRIE is to develop new experimental capabilities needed to fill the existing gaps in our fundamental understanding of materials important for key National Nuclear Security Agency (NNSA) goals. MaRIE will bring two major new capabilities: (a) the ability to characterize the meso- and microstructure of materials in bulk as well as local dynamic response characteristics, and (b) the ability to characterize how this microstructure evolves under NNSA-relevant conditions and impacts the material’s performance in this regime.

  3. 5. Historic American Buildings Survey Photocopy of undated photo after ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Photocopy of undated photo after 1903 in Harvard Archives, Harvard University, Cambridge, Massachusetts EXTERIOR FROM CORNER OF QUINCY AND CAMBRIDGE STREETS - Mrs. David Greenough House, 42 Quincy Street, Cambridge, Middlesex County, MA

  4. 48. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior detail of water and hydraulic pumps VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  5. Comparison of TCeMA and TDMA for Inter-Satellite Communications using OPNET Simulation

    NASA Technical Reports Server (NTRS)

    Hain, Regina Rosales; Ramanathan, Ram; Bergamo, Marcos; Wallett, Thomas M.

    2003-01-01

    A robust data link protocol, enabling unique physical and MAC layer technologies and sub-network level protocols, is needed in order to take advantage of the full potential of using both TDMA and CDMA in a satellite communication network. A novel MAC layer protocol, TDMA with CDMA-encoding multiple access (TCeMA) integrated with null-steered digital beam-forming spatial multiplexing, is investigated to support flexible spacecraft communications. Abstract models of the TCeMA and TDMA processes are developed in OPNFiT and a comparison of the performances of TCeMA and TDMA in a satellite network simulation are made. TCeMA provides the better connectivity and capacity with respect to TDMA for satellite communication traffic.

  6. 76 FR 72309 - Drawbridge Operation Regulations; Chelsea River, Chelsea and East Boston, MA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... No. USCG-2011-1050] Drawbridge Operation Regulations; Chelsea River, Chelsea and East Boston, MA...-2011-1050 and are available online at http://www.regulations.gov , inserting USCG-2011-1050 in...

  7. 75 FR 15740 - Valentine Tool and Stamping, Inc.: Norton, MA; Notice of Termination of Investigation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Valentine Tool and Stamping, Inc.: Norton, MA; Notice of Termination... of Valentine Tool and Stamping, Inc., Norton, Massachusetts. The petitioner has requested that...

  8. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  9. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  10. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  11. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  12. 46 CFR 308.534 - Certificate to be attached to closing report, Form MA-313-A.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... to be attached to the closing report, Form MA-313-A, may be obtained from the American War...

  13. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War...

  14. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. 872.3500 Section 872.3500...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. (a) Identification. Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC)...

  15. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. 872.3500 Section 872.3500...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. (a) Identification. Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC)...

  16. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. 872.3500 Section 872.3500...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. (a) Identification. Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC)...

  17. 21 CFR 872.3500 - Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. 872.3500 Section 872.3500...), acid copolymer, and carboxymethylcellulose sodium (NACMC) denture adhesive. (a) Identification. Polyvinylmethylether maleic anhydride (PVM-MA), acid copolymer, and carboxymethylcellulose sodium (NACMC)...

  18. 77 FR 31329 - Northeast Fisheries Science Center, Woods, Hole, MA; Public Meeting/Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Northeast Fisheries Science Center, Woods, Hole, MA; Public Meeting/Workshop AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and...

  19. Astronaut Scott Carpenter on recovery ship U.S.S. Intrepid after MA-7 flight

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Astronaut M. Scott Carpenter, prime pilot for the Mercury-Atlas 7 (MA-7) mission, arrives aboard the prime recovery ship, U.S.S. Intrepid, during recovery operations following his earth-orbital mission.

  20. Tectonic implications of post-30 Ma Pacific and North American relative plate motions

    USGS Publications Warehouse

    Bohannon, R.G.; Parsons, T.

    1995-01-01

    The Pacific plate moved northwest relative to North America since 42 Ma. The rapid half rate of Pacific-Farallon spreading allowed the ridge to approach the continent at about 29 Ma. Extinct spreading ridges that occur offshore along 65% of the margin document that fragments of the subducted Farallon slab became captured by the Pacific plate and assumed its motion proper to the actual subduction of the spreading ridge. This plate-capture process can be used to explain much of the post-29 Ma Cordilleran North America extension, strike slip, and the inland jump of oceanic spreading in the Gulf of California. Much of the post-29 Ma continental tectonism is the result of the strong traction imposed on the deep part of the continental crust by the gently inclined slab of subducted oceanic lithosphere as it moved to the northwest relative to the overlying continent. -from Authors

  1. 78 FR 20687 - Nantucket National Wildlife Refuge, Nantucket, MA; Final Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... Fish and Wildlife Service Nantucket National Wildlife Refuge, Nantucket, MA; Final Comprehensive Conservation Plan and Finding of No Significant Impact AGENCY: Fish and Wildlife Service, Interior. ACTION... conservation concern using this habitat, providing wildlife-dependent priority public uses when...

  2. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  3. 75 FR 41524 - Cranston Print Works Company, Webster Division, Webster, MA; Cranston Print Works Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... Employment and Training Administration Cranston Print Works Company, Webster Division, Webster, MA; Cranston Print Works Company, Corporate Offices, Cranston, RI; Amended Certification Regarding Eligibility To... for Worker Adjustment Assistance on February 6, 2009, applicable to workers of Cranston Print...

  4. 46 CFR 308.534 - Certificate to be attached to closing report, Form MA-313-A.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... to be attached to the closing report, Form MA-313-A, may be obtained from the American War...

  5. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War...

  6. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War...

  7. 46 CFR 308.534 - Certificate to be attached to closing report, Form MA-313-A.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... to be attached to the closing report, Form MA-313-A, may be obtained from the American War...

  8. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance... application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War...

  9. 75 FR 21367 - Advanced Electronics, Inc.; Boston, MA; Notice of Negative Determination on Remand

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... Employment and Training Administration Advanced Electronics, Inc.; Boston, MA; Notice of Negative... Department of Labor (Department) for further investigation Former Employees of Advanced Electronics, Inc. v... Adjustment Assistance (ATAA) applicable to workers and former workers of Advanced Electronics, Inc.,...

  10. 21 Ma Eclogite From the Main Central Thrust Sheet, Eastern Nepal Himalaya

    NASA Astrophysics Data System (ADS)

    Corrie, S. L.; Kohn, M. J.; Vervoort, J. D.; Parkinson, C. D.

    2007-12-01

    Though uncommon throughout the Himalaya, eclogites have been documented in the Kaghan Valley of Pakistan, the Tso Morari dome in India, the Kharta region of Tibet, and the Makalu-Everest region of the Arun River valley in eastern Nepal. The Kaghan and Tso Morari UHP eclogites have been dated at ~50 Ma, and are commonly viewed as reflecting aborted subduction of the leading edge of the Indian plate during the initial stages of Indo- Asian collision. Here we show that the Arun eclogites are significantly younger, only ~21 Ma, so reflect either different origins, or substantial time lags in tectonics along strike. The Arun eclogites are stratigraphically continuous with the surrounding Greater Himalayan Sequence (GHS) felsic gneisses, and have been interpreted as metamorphosed basaltic sills. P-T conditions have been estimated at >14 kbar at 670-710 °C. The GHS in this region overlies Lesser Himalayan rocks along the Main Central Thrust (MCT), which can be traced for over 2000 km along strike. Lu-Hf dates from garnet separates in one relict eclogite indicate an age of 20.7±0.4 Ma (MSWD = 2.2). Five garnet amphibolites from nearby were also dated via Lu-Hf, and their ages range from 14-20 Ma (13.9±2.5, 14.1±0.3, 14.5±2.8, 15.1±0.6, and 19.8±1.1 Ma). The ~21 Ma age obtained from the eclogite postdates eclogite ages from the western Himalaya (Kaghan and Tso Morari) by ~30 Myr, and has important implications for tectonic models of Himalayan orogenesis. One possible model is that (aborted) subduction, slab breakoff, and ascent of India's leading edge occurred diachronously: ~50 Ma in the western Himalaya, ~20 Ma in eastern Nepal, and presumably even younger in the eastern Himalaya. Alternatively, because the Arun eclogites did not reach ultra-high pressure conditions seen by western eclogites (only ≥45, not ≥90 km depth), they may simply reflect deepening or longer transport of the MCT in the Arun area. Regardless, a ~21 Ma age for these eclogites combined with

  11. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line

    PubMed Central

    Park, Kwang Il; Kim, Dong Gun; Lee, Bo Hyoung

    2016-01-01

    Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis (UC). IBD increases the risk of colorectal cancer (CRC), depending on the extent and duration of intestinal inflammation. Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ). KIOM-MA is a specific agent for allergic diseases and cancer, and it is composed of several plants; these herbs have been used in traditional oriental medicine. We fermented KIOM-MA, the product of KIOM-MA128, using probiotics to improve the therapeutic efficacy via the absorption and bioavailability of the active ingredients. In this study, we demonstrated that KIOM-MA/MA128 exhibited anticolitis effects via the modulation of TJ protein. Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 µg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. Furthermore, protein and mRNA TJ levels remained stable after pretreatment with 400 µg/ml KIOM-MA/MA128. Moreover, KIOM-MA/MA128 suppressed the expression of PLCγ1 and PKC. Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction. PMID:27980357

  12. 77 FR 73053 - Comment Request for Information Collection on Administrative Procedures Including Form MA 8-7...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... Procedures Including Form MA 8-7, Extension Without Revisions AGENCY: Employment and Training Administration... collection of data consistent with 20 CFR 601, including Form MA 8-7, which expires June 30, 2013. DATES.... The information transmitted by Form MA 8-7 is used by the Secretary to make findings (as specified...

  13. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    NASA Astrophysics Data System (ADS)

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-08-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10–20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules.

  14. Trypsin-treated Ma-104: a sensitive cell line for isolating enteric viruses from environmental samples.

    PubMed Central

    Agbalika, F; Hartemann, P; Foliguet, J M

    1984-01-01

    During a 1-year survey of enteroviruses in wastewater samples from the Lorraine area, three widely used continuous monkey kidney cell lines were tested: BGM, Vero, and trypsin-treated Ma-104. Decontaminated samples from secondary wastewater treatment plants (influent or effluent) were directly inoculated onto cells, and viruses were revealed after two passages with a liquid medium technique. Out of the total percentage of positive isolates with the three systems (32.7) 24.7% were found with Ma-104, 14.1% with BGM, and only 1.7% with Vero cells. Poliovirus was recovered more frequently with Ma-104 (12.3%) than with BGM (1.7%). Reovirus (3.5%) and echovirus (1.7%) were only found with Ma-104 cells; however, BGM cells allowed the isolation of a few group B coxsackieviruses (5.9%). It must be pointed out that 7.0% of samples with an unconfirmed cytopathic effect were found with BGM against 3.4% found with Ma-104, but they did not have significant differences. Because of its large spectrum of sensitivity, easy maintenance, and resistance to toxic effects, trypsin-treated Ma-104 may be recommended in conjunction with other cell lines for the detection of viruses from environmental samples, especially with the use of a liquid method. PMID:6324675

  15. Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

    PubMed Central

    Shirahama, Hitomi; Lee, Bae Hoon; Tan, Lay Poh; Cho, Nam-Joon

    2016-01-01

    Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synthesis by systematically examining reaction parameters including carbonate-bicarbonate (CB) buffer molarity, initial pH adjustment, MAA concentration, gelatin concentration, reaction temperature, and reaction time. We employed several analytical techniques in order to determine the degree of substitution (DS) and conducted detailed structural analysis of the synthesized polymer. The results enabled us to optimize GelMA synthesis, showing the optimal conditions to balance the deprotonation of amino groups with minimizing MAA hydrolysis, which led to nearly complete substitution. The optimized conditions (low feed ratio of MAA to gelatin (0.1 mL/g), 0.25 M CB buffer at pH 9, and a gelatin concentration of 10–20%) enable a simplified reaction scheme that produces GelMA with high substitution with just one-step addition of MAA in one pot. Looking forward, these optimal conditions not only enable facile one-pot GelMA synthesis but can also guide researchers to explore the efficient, high methacrylation of other biomacromolecules. PMID:27503340

  16. Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

    NASA Astrophysics Data System (ADS)

    Gonzalez Ortiz, Andrea

    2017-01-01

    We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

  17. MaGate Simulator: A Simulation Environment for a Decentralized Grid Scheduler

    NASA Astrophysics Data System (ADS)

    Huang, Ye; Brocco, Amos; Courant, Michele; Hirsbrunner, Beat; Kuonen, Pierre

    This paper presents a simulator for of a decentralized modular grid scheduler named MaGate. MaGate’s design emphasizes scheduler interoperability by providing intelligent scheduling serving the grid community as a whole. Each MaGate scheduler instance is able to deal with dynamic scheduling conditions, with continuously arriving grid jobs. Received jobs are either allocated on local resources, or delegated to other MaGates for remote execution. The proposed MaGate simulator is based on GridSim toolkit and Alea simulator, and abstracts the features and behaviors of complex fundamental grid elements, such as grid jobs, grid resources, and grid users. Simulation of scheduling tasks is supported by a grid network overlay simulator executing distributed ant-based swarm intelligence algorithms to provide services such as group communication and resource discovery. For evaluation, a comparison of behaviors of different collaborative policies among a community of MaGates is provided. Results support the use of the proposed approach as a functional ready grid scheduler simulator.

  18. High-resolution reconstructions of Pacific-North America plate motion: 20 Ma to present

    NASA Astrophysics Data System (ADS)

    DeMets, C.; Merkouriev, S.

    2016-11-01

    We present new rotations that describe the relative positions and velocities of the Pacific and North America plates at 22 times during the past 19.7 Myr, offering ≈1-Myr temporal resolution for studies of the geotectonic evolution of western North America and other plate boundary locations. Derived from ≈18 000 magnetic reversal, fracture zone and transform fault identifications from the Pacific-Antarctic-Nubia-North America plate circuit and the velocities of 935 GPS sites on the Pacific and North America plates, the new rotations and GPS-derived angular velocity indicate that the rate of motion between the two plates increased by ≈70 per cent from 19.7 to 9±1 Ma, but changed by less than 2 per cent since 8 Ma and even less since 4.2 Ma. The rotations further suggest that the relative plate direction has rotated clockwise for most of the past 20 Myr, with a possible hiatus from 9 to 5 Ma. This conflicts with previously reported evidence for a significant clockwise change in the plate direction at ≈8-6 Ma. Our new rotations indicate that Pacific plate motion became obliquely convergent with respect to the San Andreas Fault of central California at 5.2-4.2 Ma, in agreement with geological evidence for a Pliocene onset of folding and faulting in central California. Our reconstruction of the northern Gulf of California at 6.3 Ma differs by only 15-30 km from structurally derived reconstructions after including 3-4 km Myr-1 of geodetically measured slip between the Baja California Peninsula and Pacific plate. This implies an approximate 15-30 km upper bound for plate non-rigidity integrated around the global circuit at 6.3 Ma. A much larger 200±54 km discrepancy between our reconstruction of the northern Gulf of California at 12 Ma and that estimated from structural and marine geophysical observations suggests that faults in northwestern Mexico or possibly west of the Baja California Peninsula accommodated large amounts of obliquely divergent dextral shear

  19. Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization

    PubMed Central

    Rajagopalan, Vinodh; Canals, Daniel; Luberto, Chiara; Snider, Justin; Voelkel-Johnson, Christina; Obeid, Lina M.; Hannun, Yusuf A

    2014-01-01

    BACKGROUND A novel murine mitochondria-associated neutral sphingomyelinase (MA-nSMase) has been recently cloned and partially characterized. The subcellular localization of the enzyme was found to be predominantly in mitochondria. In this work, the determinants of mitochondrial localization and its topology were investigated. METHODS MA-nSMase mutants lacking consecutive regions and fusion proteins of GFP with truncated MA-nSMase regions were constructed and expressed in MCF-7 cells. Its localization was analyzed using confocal microscopy and sub-cellular fractionation methods. The sub-mitochondrial localization of MA-nSMase was determined using protease protection assay on isolated mitochondria. RESULTS The results initially showed that a putative mitochondrial localization signal (MLS), homologous to an MLS in the zebra-fish mitochondrial SMase is not necessary for the mitochondrial localization of the murine MA-nSMase. Evidence is provided to the presence of two regions in MA-nSMase that are sufficient for mitochondrial localization: a signal sequence (amino acids 24–6) that is responsible for the mitochondrial localization and an additional 'signal-anchor' sequence (amino acids 77–99) that anchors the protein to the mitochondrial membrane. This protein is topologically located in the outer mitochondrial membrane where both the C and N-termini remain exposed to the cytosol. CONCLUSIONS MA-nSMase is a membrane anchored protein with a MLS and a signal-anchor sequence at its N-terminal to localize it to the outer mitochondrial membrane. GENERAL SIGNIFICANCE Mitochondrial sphingolipids have been reported to play a critical role in cellular viability. This study opens a new window to investigate their cellular functions, and to define novel therapeutic targets. PMID:25484313

  20. The ca. 1380 Ma Mashak igneous event of the Southern Urals

    NASA Astrophysics Data System (ADS)

    Puchkov, Victor N.; Bogdanova, Svetlana V.; Ernst, Richard E.; Kozlov, Vjacheslav I.; Krasnobaev, Arthur A.; Söderlund, Ulf; Wingate, Michael T. D.; Postnikov, Alexander V.; Sergeeva, Nina D.

    2013-08-01

    A review of the geochronology, geochemistry and distribution of the 1380 Ma Mashak Large Igneous Province (LIP) of the eastern margin of the East European craton indicates a potential link to a major breakup stage of the Mesoproterozoic supercontinent Columbia (Nuna), link to a major stratigraphic boundary (Lowe-Middle Riphean), and economic significance for hydrocarbons and metallogeny. Specifically, the Mashak event likely has much greater extent than previously realized. Two U-Pb baddeleyite (ID TIMS) age determinations on dolerite sills obtained from borehole (Menzelinsk-Aktanysh-183) confirm the western extent of the Mashak event into the crystalline basement of the East European Craton (1382 ± 2 Ma) and into the overlying Lower Riphean sediments (1391 ± 2 Ma), and the imprecise ages reported elsewhere indicate the possible extension into the Timan region, with an overall areal extent of more than 500,000 km2 (LIP scale). It has tholeiitic compositions and is associated with breakup on the eastern margin of the craton - in addition, precise SHRIMP zircon ages of 1386 ± 5 Ma and 1386 ± 6 Ma (this paper) provide confirmation of previous approximate 1380-1383 Ma zircon age determination of the same formation, and suggest an age of ca. 1.4 Ga for the Lower/Middle Riphean boundary which was formerly considered to be 1350 ± 10 Ma. Contemporaneous magmatic rocks in the northeastern Greenland part of Laurentia (Zig-Zag Dal and Midsommerso formations) and Siberia (Chieress dykes and other dolerites) together with the Mashak event are suggested to be fragments of a single huge LIP and to correspond to breakup stage of the Columbia (Nuna) supercontinent. The Mashak LIP also has some significance, at least in Volgo-Uralia, for hydrocarbons and metallogeny.

  1. Effects of Tremella mesenterica on steroidogenesis in MA-10 mouse Leydig tumor cells.

    PubMed

    Lo, H-C; Chen, Y-W; Chien, C-H; Tseng, C-Y; Kuo, Y-M; Huang, B-M

    2005-01-01

    Tremella mesenterica (TM), a yellow jelly mushroom, has been traditionally used as food and crude medicine to improve several kinds of symptoms in Chinese society for a long time. Recent studies have illustrated that the fractions of fruiting bodies of TM exhibit a significant hypoglycemic activity in diabetic mouse models, which usually suffer from sexual dysfunction. In a previous study, we showed that TM reduced plasma testosterone production in normal rats without any positive effect in diabetic rats. It evolved a question of TM directly regulating Leydig cell steroidogenesis. In this study, MA-10 mouse Leydig tumor cells were treated with vehicle, different dosages of TM with or without human chorionic gonadotropin (hCG 50 ng/ml) to clarify the effects. Results showed that TM at different dosages (0.01-10 mg/ml) did not have any effect on MA-10 cell steroidogenesis (p > 0.05). In the presence of hCG, there was an inhibitory trend that TA suppressed MA-10 cell progesterone production at 3 hr treatment with a statistically significant difference by the 10 mg/ml TM (p < 0.05). In time course effect, TM alone did not have any effect on MA-10 cell steroidogenesis from at 1, 2, 3, 6 and 12 hr (p > 0.05). However, TM did reduce hCG-treated MA-10 cell progesterone production at 1, 2 and 3 hr (p < 0.05), respectively. To determine whether TM would have adverse effects on MA-10 cell steroidogenesis in the presence of hCG, MTT assay and recovery studies were conducted. MTT assay indicated that TM had no effect on surviving cells. In addition, with the removal of TM, and then the addition of hCG (2 and 4 hr), progesterone levels were restored within 4 hr. Taken together, present studies suggested that TM suppressed hCG-treated steroidogenesis in MA-10 cells without any toxicity effect.

  2. The development of high cooling power and low ultimate temperature superfluid Stirling refrigerators

    NASA Astrophysics Data System (ADS)

    Patel, Ashok B.

    demonstrated and further work is still required. However, despite these difficulties, one of the two stage SSR's was able to reach an ultimate low temperature of 248 mK from a high temperature of 1.03 K. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  3. Electroweak measurements using heavy quarks identified in e(+)e(-) annihilation

    NASA Astrophysics Data System (ADS)

    Rodin, Jonathan P.

    1998-12-01

    Since 1989, the Large Electron Positron collider at CERN has been used to study electroweak physics to an unprecedented precision. The data have acted as spectacular confirmation of the Standard Model as the best description of electroweak interactions at scales of ~100 GeV. However, in 1995, a possible anomaly appeared in the LEP measurement of Rb=[Γ(Z/to b/bar b)/overΓ(Z/to[ hadrons])] which was more than three standard deviations above the Standard Model prediction. This effect could not be accounted for by minor adjustment of model parameters, in particular the mass of the top quark which had recently been directly measured at the Fermilab Tevatron. In order to investigate whether the deviation could be an indication of physics beyond the Standard Model we present new precise measurements of both Rb and the forward- backward asymmetry of b quark production, AFBb, using ~63 pb-1 of data at the Z peak recorded by the L3 detector during 1994-95. The results are:/eqalign[Rb&=0.2146/pm0.0017(stat)/pm0.0033(sys)- 0.139/ (Rc-0.171)/cr AFBb&=9.33/pm1.40(stat)/pm.0.65(sys)/ pm0.10(QCD)/%/cr]This value for Rb agrees with the Standard Model to within one standard deviation. AFBb leads to a value for the effective weak mixing angle for b- quarkssin2θweff=0.2333/ pm0.0025(stat)/pm 0.0012(sys)which is consistent with values obtained using different decay modes of the Z and from neutrino physics, supporting flavour universality. We thus observe no deviation from the Standard Model and, from the Rb measurement, limit the effects of new physics to <1.7% in b decays. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139- 4307. Ph. 617-253-5668; Fax 617-253-1690.)

  4. An X-ray spectroscopic study of the SMC X-1/Sk 160 X-ray binary system

    NASA Astrophysics Data System (ADS)

    Wojdowski, Patrick Stephen

    1999-11-01

    In this thesis, the properties of the circumstellar environment of the high-mass X-ray binary system SMC X- 1/Sk 160 are explored using observational data from several satellite X-ray observatories. First, we have investigated the cause of the quasiperiodic ~60 day high-state low-state X-ray flux variation, previously suggested, and now clearly evident in extensive BATSE and RXTE monitoring data. Data from short-term pointed observations with the Ginga, ROSAT, ASCA, and RXTE observatories, show that while the uneclipsed flux varies by as much as a factor of 20 between high and low states, the eclipsed flux consists of approximately the same flux of reprocessed radiation in both states. From this we conclude that the high-low cycle is due to a quasi-periodic occultation of the source, most likely by a precessing tilted accretion disk around the neutron star. Next, we investigate the composition and distribution of the wind of Sk 160, the supergiant companion of the X-ray star SMC X-1, by comparing an X-ray spectrum of the source, obtained with the ASCA observatory during an eclipse with the computed spectra of reprocessed radiation from circumstellar matter with various density distributions. We show that the metal abundance in the wind of SMC X-1 is no greater than a few tenths of solar, as has been determined for other objects in the Magellanic Clouds. We also show that the observed spectrum is not consistent with the density distributions of circumstellar matter of the spherically symmetric form derived for line-driven winds, nor the density distribution from a hydrodynamic simulation of the X-ray perturbed and line-driven wind by Blondin & Woo (1995). Essential properties of a density distribution that would yield agreement with the observed spectrum are defined. Finally, we discuss prospects for future studies of this kind based on high-resolution spectroscopy data expected from the AXAF mission. (Copies available exclusively from MIT Libraries, Rm. 14-0551

  5. Array Processing and Forward Modeling Methods for the Analysis of Stiffened, Fluid-Loaded Cylindrical Shells.

    NASA Astrophysics Data System (ADS)

    Bondaryk, Joseph E.

    procedure estimates the compressional wavespeed at 5284m/sec and a compressional decay rate of 49dB/msec. Small cross -coupling coefficients between flexural and compressional wavetypes at the slope discontinuities on the Empty shell are found to be responsible for most of the radiation later in time. High reflection coefficients at the ring stiffeners on the Ribbed shell are shown to cause energy compartmentalization in the bays between ribs and pressure doubling of incident structural waves at the ribs. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  6. Cellular Automata Methods in Mathematical Physics.

    NASA Astrophysics Data System (ADS)

    Smith, Mark Andrew

    , and the dynamics of solids. Basic elements of a calculus for CA are proposed including a discrete representation of one-forms and an analog of integration. Eventually, it may be the case that physicists will be able to formulate cellular automata rules in a manner analogous to how they now derive differential equations. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  7. Magnetic Flux Reconstruction Methods for Shaped Tokamaks

    NASA Astrophysics Data System (ADS)

    Tsui, Chi-Wa.

    outside our operationally valid region, given the current set of the trial functions inside the variation method. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  8. a Measurement of the Longitudinal-Transverse Interference Structure Function from the Deuterium

    NASA Astrophysics Data System (ADS)

    McIlvain, Thomas Robert

    This thesis describes the results of a deuterium electrodisintegration experiment performed at the Bates Linear Accelerator Center. We scattered electrons from deuterium nuclei in a CD_2 target, detecting the scattered electron and the ejected proton in coincidence. By measuring the D(e,e'p) cross section at two different angles of proton emission, with fixed values of the energy transfer, omega ~ 109 MeV, and momentum transfer, q ~ 400 MeV/c, we extracted the longitudinal-transverse interference structure function, R_{LT }. R_{LT} is one of the four structure functions that contribute to the unpolarized coincidence cross section. We performed the experiment in the Bates North Hall using the Energy Loss Spectrometer System (ELSSY) to detect electrons and the prototype Out-Of-Plane Spectrometer (OOPS) to detect protons. Electrons of incident energies 576 MeV were scattered at angles of 44^circ. Protons were detected in non-parallel kinematics at angles of -64.7^circ (theta_{pq } ~ 11^circ 'right' of vec q) and -42.9^ circ (theta_{pq} ~ 11^circ 'left' of vec q). In order to maximize the statistical precision of the measurements, the cross sections and the structure function are averaged over a region of 81 to 106 MeV/c in missing momentum, p_{m}. We compared the data to several calculations done by H. Arenhoevel. The most interesting physics was seen in the observable A_phi, the left-right asymmetry or difference/sum of the cross sections. A_phi was the only measured observable with minimal theoretical uncertainty. Thus, the theory-data comparison using A_phi was the most telling. A_phi was measured with statistical and systematic uncertainties of 12.8% and 10.8%, respectively. At this level of precision, it was concluded that the data showed a preference for the Arenhoevel relativistic full calculation over his non -relativistic full calculation. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  9. a Separation of the Longitudinal and Transverse Structure Functions in the Deuterium

    NASA Astrophysics Data System (ADS)

    Jordan, David Victor

    described. In order to maximize the statistical precision of the measurements, the cross sections and the separated response functions are averaged over a region of 30 to 70 MeV/c in missing momentum, p_{m}. The response functions are measured with statistical and systematic uncertainties of 4% and 8%, respectively. We compare the data to a non-relativistic calculation due to H. Arenhovel, as well as to previous data measured in experiments at NIKHEF and Saclay. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  10. Optical coherence tomography of the eye

    NASA Astrophysics Data System (ADS)

    Hee, Michael Richard

    1997-10-01

    . OCT images have been correlated with visual field performance and optic nerve appearance in a cross- section of patients with various stages of glaucoma. These studies suggest that OCT has the potential to become an important diagnostic tool for the practicing ophthalmologist. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  11. Conformal cooling and rapid thermal cycling in injection molding with 3D printed tools

    NASA Astrophysics Data System (ADS)

    Xu, Xiaorong

    structure is presented. A set of tools has been fabricated and subjected to thermal and mechanical tests. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  12. Electronic and optical properties of novel carbon structures

    NASA Astrophysics Data System (ADS)

    Matthews, Manyalibo Joseph

    . Raman spectroscopy is also used with magnetic susceptibility measurements to show that the large diamagnetism of graphitic crystallites in the higher THT systems is strongly influenced by the confinement of quasi-two dimensional π-electrons within crystallites. For higher amounts of disorder within carbon crystallites, magnetoresistance measurements show that in-plane elastic scattering centers give rise to quantum coherent backscattering (i.e. 'weak localization') in certain intermediate THT carbon fibers. Along with presenting the optical and electronic properties of these carbon structures, we also discuss, for comparison, analogous low-dimensional structures based on metal (W, Mo) dichalcogenides and silicon clathrates (Si46). (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  13. Design and evaluation of cellular power converter architectures

    NASA Astrophysics Data System (ADS)

    Perreault, David John

    . This cellular system implements entirely distributed control, and achieves performance levels unattainable with an equivalent single converter. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  14. Femtosecond Carrier Dynamics in Aluminum Gallium Arsenide.

    NASA Astrophysics Data System (ADS)

    Ulman, Morrison

    available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617 -253-5668; Fax 617-253-1690.).

  15. Observation and modeling of atmospheric oxygen millimeter-wave transmittance

    NASA Astrophysics Data System (ADS)

    Schwartz, Michael Jonathan

    1998-12-01

    implication of the current results is that errors in the oxygen absorption model are not the source of observed discrepancies. Reexamination of the satellite instruments' response characteristics is indicated. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  16. Modeling of and experiments on electromagnetic levitation for materials processing

    NASA Astrophysics Data System (ADS)

    Hyers, Robert W.

    measurements were performed in microgravity on the Space Shuttle. These experiments depend on careful control of the fluid flow in the sample, based on the MHD model presented. The measurements use the oscillating drop technique to provide very precise containerless measurement of surface tension, and the first containerless measurement of viscosity. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253- 1690.)

  17. Multifluid Nonequilibrium Simulation of Arcjet Thrusters.

    NASA Astrophysics Data System (ADS)

    Miller, Scott Alan

    predicted by the arcjet simulation of this research. (Copies available exclusively from MIT Libraries, Rm 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  18. Current distribution and stability criteria for superconducting cables in transient magnetic fields

    NASA Astrophysics Data System (ADS)

    Ferri, Matthew Anthony

    1997-08-01

    propose suggestions for minimizing circulating currents in order to improve the performance of superconducting cables in transient magnetic fields. Directions for future investigations are also proposed. (Copies available exclusively from MIT libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  19. Freezing of sulfuric and nitric acid solutions: Implications for polar stratospheric cloud formation

    NASA Astrophysics Data System (ADS)

    Salcedo Gonzalez, Dara

    2000-12-01

    than one day. This might be an important mechanism to form mixed liquid-solid clouds, which seem to be the precursors for denitrification cation in the stratosphere. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  20. A system dynamics model of a large R&D program

    NASA Astrophysics Data System (ADS)

    Ahn, Namsung

    goals can be implemented easily and allocations adjusted to enhance continuously the likelihood of success, and to optimize payoffs. Finally, this model can give managers a quantitative rationale for program evaluation and permit the quantitative assessment of various externally imposed changes. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  1. Studies of novel 140 GHz gyrotrons

    NASA Astrophysics Data System (ADS)

    Hu, Wen

    We have designed, built and tested the world's first mode-selective confocal cavity gyrotron oscillator operating at 140GHz with over 66kW of RF power and up to 23% efficiency. The tube operates at the HE06 mode of the confocal cavity. A Magnetotron Injection Gun (MIG) provides an annular electron beam with up to 70kV and 8A. The confocal gyrotron oscillator is designed to better characterize the confocal cavity's mode spectrum for future amplifier applications. The device utilizes the interaction between an electron beam in cyclotron motion and the cavity mode in an open two-mirror confocal cavity are suppressed, and only gaussian-like modes can propagate with small loss. As a result, the confocal geometry reduces mode indices from two dimensional TEn,m to one dimensional HE0,q in confocal waveguide. The greatly reduced mode density of this structure lowers the risk of spurious mode competition, which is a critical issue in gyrotron development. Several models were formulated for various configurations of gyrotrons. A nonlinear theory for the mirror based quasi-optical Gyrotron Traveling Wave Tube (Gyro-TWT) was developed for the first time. The Gyro-TWT consists of a series of parallel spherical mirrors. A free space Gaussian beam propagates through the structure by bouncing between the mirrors in a serpentine path. A co- propagating electron beam in gyromotion interacts with and the amplifies the wave. The model shows excellent agreement with the well benchmarked linear theory. The phase front distortion effect in the quasi-optical gyro- TWT is revealed by this model. A preliminary confocal waveguide based gyro-TWT amplifier is designed. Cold tests of the quasi-optical input circuit show good gaussian beam transport with low loss. The amplifier performance is theoretically predicted to have a 4dB/cm linear gain, 20% efficiency and 70kW RF power. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  2. Experimental study of a 1 MW, 170 GHz gyrotron oscillator

    NASA Astrophysics Data System (ADS)

    Kimura, Takuji

    , from which the beam velocity spreads are estimated. A preliminary test of the mode converter shows that the radiation from the dimpled wall launcher is a Gaussian-like beam. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139- 4307. Ph. 617-253-5668; Fax 617-253-1690.)

  3. Electric field imaging

    NASA Astrophysics Data System (ADS)

    Smith, Joshua Reynolds

    of applications of electric field sensing, many enabled by the small footprint of the LazyFish. To demonstrate the School of Fish hardware and the Sphere Expansion inversion method, the thesis presents 3 dimensional position and orientation tracking of two hands. 1 (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.) 1Please see the URL http://www.media.mit.edu/people/jrs/thesis.html for video clips, code, and other information related to this thesis.

  4. Kerr electrooptic tomography for determination of nonuniform electric field distributions in dielectrics

    NASA Astrophysics Data System (ADS)

    Ustundag, Afsin

    axisymmetric media the onion peeling algorithm of radially discretized concentric circular regions is developed and successfully applied to reconstruct the applied electric field. Finally, algebraic reconstruction techniques which have been developed in Japan in a research parallel to this one are studied and compared to our algorithms. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  5. Electrostatic Properties of Phase-Separating Bovine Lens Proteins.

    NASA Astrophysics Data System (ADS)

    Kovach, Ian Shand

    1992-01-01

    Acid-base titration experiments were conducted to determine the net charge on four bovine lens proteins: gamma_{rm II}, gamma_{rm IIIa}, gamma_{rm IIIb}, gamma_{rm IV}. In addition to the dependence of protein charge on pH, the effects of ionic strength and identity on protein charge were investigated. Titration curves were obtained in 0.1 M KCl, 0.1 M NaCl, 0.1 M NaBr, and 0.01 M KCl. Three theoretical methods, the Linderstrom-Lang model, a modification of the Linderstrom-Lang model which does not linearize the Poisson-Boltzmann equation, and the Kirkwood-Tanford model were used to correct intrinsic proton binding energies in an effort to predict protein charge as a function of solution conditions. The electrostatic interaction energy between protein and solvent was determined using the Linderstrom-Lang model. The acid-base titration curves of the four proteins were found to be very similar, with the exception of basic range titration of gamma_{rm IIIb} which exhibited slightly greater negative charge near pH 10. No evidence of protein charge dependence on the identity of electrolyte was observed. A dependence of protein charge on ionic strength was observed. Decreasing ionic strength was found to correlate with decreasing magnitude of net protein charge at a given pH. The theoretical Linderstrom-Lang titration curves were found to be in fair agreement with the experimental results over a pH range of 5 to 11, and in poor agreement in the pH extremes. The nonlinearized variation of the Linderstrom-Lang model was found to be in good agreement with the titration curves from pH 2 to pH 11. The theoretical Kirkwood-Tanford titration curves were determined for gamma_{rm II} and also found to be in excellent agreement with experimental results. The precise location of protein charge on gamma_{rm II}, as a function of pH, was determined using the Kirkwood-Tanford model. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617

  6. The Interaction of Sound and Shock Waves with Flexible Porous Materials

    NASA Astrophysics Data System (ADS)

    Abbott, James Fuller

    often introduce significant errors into the subsequent estimate of K. We then provide a computer algorithm which makes the long-wavelength assumption unnecessary. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253 -1690.) (Abstract shortened with permission of school.).

  7. Magnetic Anisotropy in Epitaxial NICKEL/COPPER(110) Thin Films and COPPER/NICKEL/COPPER(001) Sandwiches

    NASA Astrophysics Data System (ADS)

    Bochi, Gabriel

    1995-01-01

    . The lower transition thickness (10 A <=q h <=q 20 A) is most likely not due to the onset of misfit dislocations at the Ni/Cu interface. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  8. Three-dimensional audio using loudspeakers

    NASA Astrophysics Data System (ADS)

    Gardner, William G.

    1997-12-01

    sound localization experiments were also conducted; the results show that head-tracking both significantly improves localization when the listener is displaced from the ideal listening location, and also enables dynamic localization cues. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  9. Measuring nanometer, three-dimensional motions with light microscopy

    NASA Astrophysics Data System (ADS)

    Davis, Charles Quentin

    not necessarily indicative of hair bundle rotation. Shear through the tectorial membrane has not been previously reported. These results demonstrate that our system can measure cochlear micromechanical processes that have previously eluded direct experimental study. (Copies available exclusively from MIT Libraries, Rm. 14- 0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  10. Modelling for Transient Optically Induced Metal - Transitions in Narrow-Gap Semiconductors and Semimetals.

    NASA Astrophysics Data System (ADS)

    Vidal, Jordina

    1994-01-01

    band gap shifts in Sb, indicate that this material can undergo a metal-insulator transition at a terahertz frequency, when illuminated by a high power short pulse laser. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.).

  11. Simulations of time-dependent three-dimensional vortices with application to Neptune's Great Dark Spot

    NASA Astrophysics Data System (ADS)

    Lebeau, Raymond Paul, Jr.

    also use the EPIC model to examine the demise of GDS-type vortices that drift too close to the equator. (Copies available exclusively from MIT Libraries. Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690).

  12. Two topics in nonperturbative lattice field theories: The U(1) quantum link model and perfect actions for scalar theories

    NASA Astrophysics Data System (ADS)

    Tsapalis, Antonios S.

    This thesis deals with two topics in lattice field theories. In the first part we discuss aspects of renormalization group flow and non-perturbative improvement of actions for scalar theories regularized on a lattice. We construct a perfect action, an action which is free of lattice artifacts, for a given theory. It is shown how a good approximation to the perfect action-referred to as classically perfect-can be constructed based on a well-defined blocking scheme for the O(3) non-linear σ-model. We study the O(N) non- linear σ-model in the large-N limit and derive analytically its perfect action. This action is applied to the O(3) model on a square lattice. The Wolff cluster algorithm is used to simulate numerically the system. We perform scaling tests and discuss the scaling properties of the large- N inspired perfect action as opposed to the standard and the classically perfect action. In the second part we present a new formulation for a quantum field theory with Abelian gauge symmetry. A Hamiltonian is constructed on a four-dimensional Euclidean space-time lattice which is invariant under local transformations. The model is formulated as a 5- dimensional path integral of discrete variables. We argue that dimensional reduction will allow us to study the behavior of the standard compact U(1) gauge theory in 4-d. Based on the idea of the loop- cluster algorithm for quantum spins, we present the construction of a flux-cluster algorithm for the U(1) quantum link model for the spin-1/2 quantization of the electric flux. It is shown how improved estimators for Wilson loop expectation values can be defined. This is important because the Wilson loops are traditionally used to identify confining and Coulomb phases in gauge theories. Our study indicates that the spin-1/2 U(1) quantum link model is strongly coupled for all bare coupling values we examined. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)

  13. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions

    PubMed Central

    Seldin, Lindsey; Poulson, Nicholas D.; Foote, Henry P.; Lechler, Terry

    2013-01-01

    The epidermis is a multilayered epithelium that requires asymmetric divisions for stratification. A conserved cortical protein complex, including LGN, nuclear mitotic apparatus (NuMA), and dynein/dynactin, plays a key role in establishing proper spindle orientation during asymmetric divisions. The requirements for the cortical recruitment of these proteins, however, remain unclear. In this work, we show that NuMA is required to recruit dynactin to the cell cortex of keratinocytes. NuMA's cortical recruitment requires LGN; however, LGN interactions are not sufficient for this localization. Using fluorescence recovery after photobleaching, we find that the 4.1-binding domain of NuMA is important for stabilizing its interaction with the cell cortex. This is functionally important, as loss of 4.1/NuMA interaction results in spindle orientation defects, using two distinct assays. Furthermore, we observe an increase in cortical NuMA localization as cells enter anaphase. Inhibition of Cdk1 or mutation of a single residue in NuMA mimics this effect. NuMA's anaphase localization is independent of LGN and 4.1 interactions, revealing two distinct mechanisms responsible for NuMA cortical recruitment at different stages of mitosis. This work highlights the complexity of NuMA localization and reveals the importance of NuMA cortical stability for productive force generation during spindle orientation. PMID:24109598

  14. Subduction of the South Chile active spreading ridge: A 17 Ma to 3 Ma magmatic record in central Patagonia (western edge of Meseta del Lago Buenos Aires, Argentina)

    NASA Astrophysics Data System (ADS)

    Boutonnet, E.; Arnaud, N.; Guivel, C.; Lagabrielle, Y.; Scalabrino, B.; Espinoza, F.

    2010-01-01

    The Chile Triple Junction is a natural laboratory to study the interactions between magmatism and tectonics during the subduction of an active spreading ridge beneath a continent. The MLBA plateau (Meseta del Lago Buenos Aires) is one of the Neogene alkali basaltic plateaus located in the back-arc region of the Andean Cordillera at the latitude of the current Chile Triple Junction. The genesis of MLBA can be related with successive opening of slabs windows beneath Patagonia: within the subducting Nazca Plate itself and between the Nazca and Antarctic plates. Detailed 40Ar/ 39Ar dating and geochemical analysis of bimodal magmatism from the western flank of the MLBA show major changes in the back-arc magmatism which occurred between 14.5 Ma and 12.5 Ma with the transition from calc-alkaline lavas (Cerro Plomo) to alkaline lavas (MLBA) in relation with slab window opening. In a second step, at 4-3 Ma, alkaline felsic intrusions were emplaced in the western flank of the MLBA coevally with the MLBA basalts with which they are genetically related. These late OIB-like alkaline to transitional basalts were generated by partial melting of the subslab asthenosphere of the subducting Nazca plate during the opening of the South Chile spreading ridge-related slab window. These basalts differentiated with small amounts of assimilation in shallow magma chambers emplaced along transtensional to extensional zones. The close association of bimodal magmatism with extensional tectonic features in the western MLBA is a strong support to the model of Patagonian collapse event proposed to have taken place between 5 and 3 Ma as a consequence of the presence of the asthenospheric window (SCR-1 segment of South Chile Ridge) below the MLBA area.

  15. Glaciation and topographic evolution of the Central Patagonian Andes since 6 Ma

    NASA Astrophysics Data System (ADS)

    Christeleit, E. C.; Laemel, R.; De Wolf, W. E.; Shuster, D. L.; Brandon, M. T.

    2013-12-01

    New and existing thermochronological data are used to model glacial erosion and topographic evolution of the central Patagonian Andes (~47S) over the last 6 Ma. The modern Andes are cut by large valleys and fjords with local valley relief of at least 2.5 km. It is currently thought that a formerly uniformly high Andes was 'buzzed' down to the elevation of the equilibrium line altitude, presumably in the last 2 Ma concurrent with late Cenozoic global cooling. However, studies of glacial debris show that glaciers were present in Patagonia as early as 6 Ma. The extent of these early glaciations is unclear, but recent work suggests that glacial valleys in the central Patagonian Andes were carved at a steady rate beginning at 6 Ma, implying that valley incision may be an important process in the topographic evolution of glaciated mountain ranges, rather than cirque retreat. To understand how valley relief has formed in the Andes, we dated 30 samples from Steffen Fjord in Chile using apatite (U-Th)/He thermochronology. We use this new data and existing thermochronological data in the region to estimate the topographic form of the central Andes at 6 Ma and model how the valley relief has evolved since the initiation of glaciation using Pecube.

  16. The regulatory mechanism of Tremella mesenterica on steroidogenesis in MA-10 mouse Leydig tumor cells.

    PubMed

    Chen, Yen-Wen; Lo, Hui-Chen; Yang, Jyuer-Ger; Chien, Chi-Hsien; Lee, Shi-Hsiung; Tseng, Chi-Yu; Huang, Bu-Miin

    2006-07-04

    Tremella mesenterica (TM), a yellow jelly mushroom, has been traditionally used as tonic food to improve body condition in Chinese society for a long time. We have previously demonstrated that TM reduced in vitro hCG-treated steroidogenesis in MA-10 mouse Leydig tumor cells without any toxicity effect. In the present study, the mechanism how TM suppressed hCG-treated steroidogenesis in MA-10 cells was investigated. MA-10 cells were treated with vehicle, human chorionic gonadotropin (hCG, 50 ng/ml), or different reagents with or without TM to clarify the effects. TM significantly suppressed progesterone production with the presences of forskolin (10 and 100 microM) or dbcAMP (0.5 and 1mM), respectively, in MA-10 cells (p<0.05), which indicated that TM suppressed steroidogenesis after PKA activation along the signal pathway. Beyond our expectation, TM induced the expression of steroidogenic acute regulatory (StAR) protein with or without hCG treatments. However, TM profoundly decreased P450 side chain cleavage (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme activities without any influences on the expression of both enzymes. These inhibitions on steroidogenic enzyme activities might counteract the stimulation of StAR protein expression. In conclusion, results suggest that TM suppressed hCG-treated steroidogenesis in MA-10 cells by inhibiting PKA signal pathway and steroidogenic enzyme activities.

  17. Using superconducting undulator for enhanced imaging capabilities of MaRIE

    SciTech Connect

    Yampolsky, Nikolai

    2016-09-22

    MaRIE x-ray free electron laser (FEL) is envisioned to deliver a burst of closely spaced in time pulses for enabling the capability of studying the dynamic processes in a sample. MaRIE capability can be largely enhanced using the superconducting undulator, which has the capability of doubling its period. This technology will allow reaching the photon energy as low as ~200-500 eV. As a result, the MaRIE facility will have a broader photon energy range enabling a larger variety of experiments. The soft x-ray capability is more likely to achieve the 3D imaging of dynamic processes in noncrystal materials than the hard x-ray capability alone.

  18. Kuznetsov-Ma waves train generation in a left-handed material

    NASA Astrophysics Data System (ADS)

    Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

    2015-03-01

    We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

  19. Earth's youngest exposed granite and its tectonic implications: the 10-0.8 Ma Kurobegawa Granite.

    PubMed

    Ito, Hisatoshi; Yamada, Ryuji; Tamura, Akihiro; Arai, Shoji; Horie, Kenji; Hokada, Tomokazu

    2013-01-01

    Although the quest for Earth's oldest rock is of great importance, identifying the youngest exposed pluton on Earth is also of interest. A pluton is a body of intrusive igneous rock that crystallized from slowly cooling magma at depths of several kilometers beneath the surface of the Earth. Therefore, the youngest exposed pluton represents the most recent tectonic uplift and highest exhumation. The youngest exposed pluton reported to date is the Takidani Granodiorite (~ 1.4 Ma) in the Hida Mountain Range of central Japan. Using LA-ICP-MS and SHRIMP U-Pb zircon dating methods, this study demonstrates that the Kurobegawa Granite, also situated in the Hida Mountain Range, is as young as ~ 0.8 Ma. In addition, data indicate multiple intrusion episodes in this pluton since 10 Ma with a ~ 2-million-year period of quiescence; hence, a future intrusion event is likely within 1 million years.

  20. Rapid glacial erosion at 1.8 Ma revealed by 4He/3He thermochronometry.

    PubMed

    Shuster, David L; Ehlers, Todd A; Rusmoren, Margaret E; Farley, Kenneth A

    2005-12-09

    Alpine glaciation and river incision control the topography of mountain ranges, but their relative contributions have been debated for years. Apatite 4He/3He thermochronometry tightly constrains the timing and rate of glacial erosion within one of the largest valleys in the southern Coast Mountains of British Columbia, Canada. Five proximate samples require accelerated denudation of the Klinaklini Valley initiating 1.8 +/- 0.2 million years ago (Ma). At least 2 kilometers of overlying rock were removed from the valley at >/=5 millimeters per year, indicating that glacial valley deepening proceeded >/=6 times as fast as erosion rates before approximately 1.8 Ma. This intense erosion may be related to a global transition to enhanced climate instability approximately 1.9 Ma.

  1. Molecular mechanisms and in vitro antioxidant effects of Lactobacillus plantarum MA2.

    PubMed

    Tang, Wei; Xing, Zhuqing; Li, Chao; Wang, Jinju; Wang, Yanping

    2017-04-15

    Lactobacillus plantarum MA2 was isolated from Chinese traditional Tibetan kefir grains. The antioxidant activities in vitro of this strain were evaluated extensively. The results showed that L. plantarum MA2 can tolerate hydrogen peroxide up to 2.0mM, and its fermentate (fermented supernatant, intact cell and cell-free extract) had strong reducing capacities, lipid peroxidation inhibition capacities, Fe(2+)-chelating abilities, as well as various free radical scavenging capacities. Additionally, both the fermented supernatant and cell homogenate exhibited glutathione peroxidase activity and superoxide dismutase activity. In order to investigate the antioxidant mechanism of L. plantarum MA2 at the molecular level, eight antioxidant-related genes were identified, and further analyzed. Three groups of genes cat, gshR and npx, were found up-regulated under H2O2 challenge.

  2. Modified variational iteration method for partial differential equations using Ma's transformation

    NASA Astrophysics Data System (ADS)

    Mohyud-Din, Syed Tauseef

    2010-03-01

    In this paper, we apply the modified variational iteration method (MVIM) for solving partial differential equations using Ma's transformation. The proposed modification is made by introducing He's polynomials in the correction functional of the variational iteration method (VIM). Moreover, we use a very efficient and reliable transformation which is mainly due to Ma and converts the given partial differential equations (PDES) into the corresponding ordinary differential equations (ODES). The proposed MVIM is applied on the re-formulated ODES, which in turn gives the solution in terms of the transformed variables and the application of the inverse transformation yields the required series solution. Several examples are given to re-confirm the efficiency and accuracy of the suggested algorithm. It is observed that Ma's transformation makes the solution procedure very convenient and simple.

  3. [Doctor Ma Kun's experience of applying tonifying kidney and promoting blood circulation treatment of anovulatory infertility].

    PubMed

    Shan, Jing

    2014-02-01

    With the ascending attack rate of anovulatory infertility year by year, people also began to pay attention to its treat methods. According to Doctor Ma Kun,who are engaged in clinical work about the treatment for anovulatory infertility, kidney deficiency is the basic pathogenesis and blood stasis is an important factor that has been through. Flexible use of tonifying the kidney and promoting blood circulation treatment of anovulatory infertility in clinic, has achieved remarkable curative effect. Director Ma adjusts menstruation by the different periods, and regulates both patients' negative emotions and sleep quality. Through years of clinical experience accumulation, Director Ma gradually formes special treatment of anovulatory infertility by flexibly using of tonifying the kidney and promoting blood circulation individually.

  4. The Banana Transcriptional Repressor MaDEAR1 Negatively Regulates Cell Wall-Modifying Genes Involved in Fruit Ripening

    PubMed Central

    Fan, Zhong-qi; Kuang, Jian-fei; Fu, Chang-chun; Shan, Wei; Han, Yan-chao; Xiao, Yun-yi; Ye, Yu-jie; Lu, Wang-jin; Lakshmanan, Prakash; Duan, Xue-wu; Chen, Jian-ye

    2016-01-01

    Ethylene plays an essential role in many biological processes including fruit ripening via modulation of ethylene signaling pathway. Ethylene Response Factors (ERFs) are key transcription factors (TFs) involved in ethylene perception and are divided into AP2, RAV, ERF, and DREB sub-families. Although a number of studies have implicated the involvement of DREB sub-family genes in stress responses, little is known about their roles in fruit ripening. In this study, we identified a DREB TF with a EAR motif, designated as MaDEAR1, which is a nucleus-localized transcriptional repressor. Expression analysis indicated that MaDEAR1 expression was repressed by ethylene, with reduced levels of histone H3 and H4 acetylation at its regulatory regions during fruit ripening. In addition, MaDEAR1 promoter activity was also suppressed in response to ethylene treatment. More importantly, MaDEAR1 directly binds to the DRE/CRT motifs in promoters of several cell wall-modifying genes including MaEXP1/3, MaPG1, MaXTH10, MaPL3, and MaPME3 associated with fruit softening during ripening and represses their activities. These data suggest that MaDEAR1 acts as a transcriptional repressor of cell wall-modifying genes, and may be negatively involved in ethylene-mediated ripening of banana fruit. Our findings provide new insights into the involvement of DREB TFs in the regulation of fruit ripening. PMID:27462342

  5. The Banana Transcriptional Repressor MaDEAR1 Negatively Regulates Cell Wall-Modifying Genes Involved in Fruit Ripening.

    PubMed

    Fan, Zhong-Qi; Kuang, Jian-Fei; Fu, Chang-Chun; Shan, Wei; Han, Yan-Chao; Xiao, Yun-Yi; Ye, Yu-Jie; Lu, Wang-Jin; Lakshmanan, Prakash; Duan, Xue-Wu; Chen, Jian-Ye

    2016-01-01

    Ethylene plays an essential role in many biological processes including fruit ripening via modulation of ethylene signaling pathway. Ethylene Response Factors (ERFs) are key transcription factors (TFs) involved in ethylene perception and are divided into AP2, RAV, ERF, and DREB sub-families. Although a number of studies have implicated the involvement of DREB sub-family genes in stress responses, little is known about their roles in fruit ripening. In this study, we identified a DREB TF with a EAR motif, designated as MaDEAR1, which is a nucleus-localized transcriptional repressor. Expression analysis indicated that MaDEAR1 expression was repressed by ethylene, with reduced levels of histone H3 and H4 acetylation at its regulatory regions during fruit ripening. In addition, MaDEAR1 promoter activity was also suppressed in response to ethylene treatment. More importantly, MaDEAR1 directly binds to the DRE/CRT motifs in promoters of several cell wall-modifying genes including MaEXP1/3, MaPG1, MaXTH10, MaPL3, and MaPME3 associated with fruit softening during ripening and represses their activities. These data suggest that MaDEAR1 acts as a transcriptional repressor of cell wall-modifying genes, and may be negatively involved in ethylene-mediated ripening of banana fruit. Our findings provide new insights into the involvement of DREB TFs in the regulation of fruit ripening.

  6. The Data Reduction Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey

    NASA Astrophysics Data System (ADS)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D'Souza, Richard; Fu, Hai; Jones, Amy; Kauffmann, Guinevere; MacDonald, Nicholas; Masters, Karen L.; Newman, Jeffrey A.; Parejko, John K.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Schlegel, David J.; Thomas, Daniel; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.; Zhang, Kai

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622-10354 Å and an average footprint of ˜500 arcsec2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ˜100 million raw-frame spectra and ˜10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ˜8500 Å and reach a typical 10σ limiting continuum surface brightness μ = 23.5 AB arcsec-2 in a five-arcsecond-diameter aperture in the g-band. The wavelength calibration of the MaNGA data is accurate to 5 km s-1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ = 72 km s-1.

  7. Ecological change in the lower Omo Valley around 2.8 Ma.

    PubMed

    Bibi, Faysal; Souron, Antoine; Bocherens, Hervé; Uno, Kevin; Boisserie, Jean-Renaud

    2013-02-23

    Late Pliocene climate changes have long been implicated in environmental changes and mammalian evolution in Africa, but high-resolution examinations of the fossil and climatic records have been hampered by poor sampling. By using fossils from the well-dated Shungura Formation (lower Omo Valley, northern Turkana Basin, southern Ethiopia), we investigate palaeodietary changes in one bovid and in one suid lineage from 3 to 2 Ma using stable isotope analysis of tooth enamel. Results show unexpectedly large increases in C(4) dietary intake around 2.8 Ma in both the bovid and suid, and possibly in a previously reported hippopotamid species. Enamel δ(13)C values after 2.8 Ma in the bovid (Tragelaphus nakuae) are higher than recorded for any living tragelaphin, and are not expected given its conservative dental morphology. A shift towards increased C(4) feeding at 2.8 Ma in the suid (Kolpochoerus limnetes) appears similarly decoupled from a well-documented record of dental evolution indicating gradual and progressive dietary change. The fact that two, perhaps three, disparate Pliocene herbivore lineages exhibit similar, and contemporaneous changes in dietary behaviour suggests a common environmental driver. Local and regional pollen, palaeosol and faunal records indicate increased aridity but no corresponding large and rapid expansion of grasslands in the Turkana Basin at 2.8 Ma. Our results provide new evidence supporting ecological change in the eastern African record around 2.8 Ma, but raise questions about the resolution at which different ecological proxies may be comparable, the correlation of vegetation and faunal change, and the interpretation of low δ(13)C values in the African Pliocene.

  8. Influence of benzoporphyrin-derivative monoacid ring A (BPD-MA, verteporfin) on murine dendritic cells

    NASA Astrophysics Data System (ADS)

    Hunt, David W. C.; King, Diane E.; Levy, Julia G.

    1997-05-01

    The impact of bensoporphyrin derivative monoacid ring A, and visible light was determined for mouse splenic dendritic cells (DC), potent antigen-presenting cells (APC) of the immune system. It was discovered that sub-lethal doses of BPD-MA and light significantly altered the surface receptor pattern of DC as well as diminishing the capacity of these cells to activate allogeneic T cells. Treatment of highly purified DC with BPD-MA and 690 nm wavelength light decreased DC expression of major histocompatibility (MHC) Class I and II antigens, leukocyte common antigen CD45, intercellular adhesion molecule-1 (ICAM-1, CD54), the co- stimulatory molecules CD80 and CD86, CD95 as well as integrin CD11c. In contrast, DC expression of leukocyte function-associated-1 (LFA-1, CD11a), CD11b, CD18, CD40, and the DC DEC-205 receptor increased after the treatment. Changes in receptor levels occurred rapidly. DC MHC Class I and ICAM-1 expression declined to 40 percent of control levels by 2 hours post-PDT. DC treated with BPD-MA and light were poor stimulators of allogeneic T cells in the mixed leukocyte reaction. BPD-MA, in the absence of light, had no effect on the immunostimulatory properties of these cells. The changes in DC receptor expression pattern produced by BPD-MA and light were comparable to those produced by ultraviolet B light, a treatment known to alter the immunostimulatory characteristics of DC. Photodynamic therapy with BPD-MA represents an innovative approach for the modification of immune reactivity.

  9. [The medical theory of Lee Je-ma and its character].

    PubMed

    Lee, Kyung-Lock

    2005-12-01

    Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  10. African absolute plate motion and True Polar Wander at about 50Ma

    NASA Astrophysics Data System (ADS)

    Harada, Y.; Wessel, P.

    2011-12-01

    Using new data set of seamount ages on the African plate, a model of motion of the African plate relative to the African hotspots are calculated by the Polygonal Finite Rotation Method; PFRM (Harada and Hamano, 2000). The new motion of the African plate has more abrupt change at about 50Ma than the previous models of the African plate mainly due to the PFRM which can allow the finite pole of the plate rotation to move continuously. The new model of the motion fits positions and ages of the almost all seamounts which are created by the African hotspots, whereas the previous models do not fit with positions of northwestern hotspots of the African plate such as Canary, Cape Verde, Meteor and Bathymetric hotspot. The new model suggests that the African plate rotated counter clockwise abruptly at about 50Ma. To compare the 50Ma abrupt change with coeval event at the Pacific plate motion, we utilized the paleomagnetic data from both plates. From the apparent geomagnetic polar wander path of the African plate and African plate motion relative to the African hotspots, we calculated geomagnetic polar motion relative to the African hotspots. Similarly, we calculated geomagnetic polar motion relative to the Pacific hotspots from the Pacific sets of paleomagnetic data and plate motion. The geomagnetic polar motion or true polar wander should be only one, therefore we can calculate relative motion of the African hotspots and the Pacific hotspots. The result shows that there was no significant motion between two groups of hotspots since about 70Ma. The new true polar wander path since 70Ma, thus, presented by averaging the two models of motions, and this has about 90 degree clockwise change of directions at about 50Ma. This study strongly suggests below. 1, There was coeval event of the African plate motion with Hawaii-Emperor bend event at the Pacific plate. 2, There was no significant relative motion between global hotspots for the time scale of 70Myr even though there was

  11. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

    PubMed Central

    Liu, Jianzhao; Zhu, Yuanxiang; Luo, Guan-Zheng; Wang, Xinxia; Yue, Yanan; Wang, Xiaona; Zong, Xin; Chen, Kai; Yin, Hang; Fu, Ye; Han, Dali; Wang, Yizhen; Chen, Dahua; He, Chuan

    2016-01-01

    DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1–0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome. PMID:27713410

  12. New Constraints on Baja California-North America Relative Plate Motion Since 11 Ma

    NASA Astrophysics Data System (ADS)

    Bennett, S. E.; Skinner, L. A.; Darin, M. H.; Umhoefer, P. J.; Oskin, M. E.; Dorsey, R. J.

    2013-12-01

    Tectonic reconstructions of the Pacific-North America (PAC-NAM) plate boundary across the Gulf of California and Salton Trough (GCAST) constrain the controversial magnitude of Baja California microplate-North America (BCM-NAM) relative motion since middle Miocene time. We use estimates of total PAC-NAM relative dextral-oblique motion from the updated global plate-circuit model (Atwater and Stock, 2013; GSA Cordilleran Mtg) to resolve the proportion of this motion on faults east of the BCM. Modern GPS studies and offset of late Miocene cross-gulf geologic tie points both suggest that BCM has never been completely coupled to the Pacific plate. Thus, our preferred GCAST reconstruction uses 93% BCM-PAC coupling from the present back to 6 Ma. We assume BCM-PAC coupling of 60% between 6 and 7 Ma, and 25% between 7 and 11 Ma, to avoid unacceptable overlap of continental crustal blocks between Baja California and the Sierra Madre Occidental (on stable NAM). Using these coupling ratios and PAC-NAM stage Euler poles, we determine the azimuth and velocity of individual points on the BCM in 1 million year increments back to 11 Ma. This procedure accounts for minor clockwise rotation of BCM that occurred during oblique rifting, and shows how total BCM-NAM relative motion increases from north to south due to greater distance from the Euler pole. Finer-scale restoration of tectonic blocks along significant (>1 km offset) faults, across extensional (e.g. pull-apart and half-graben) basins, and by vertical-axis rotation is constrained by local geologic and marine-geophysical datasets and accomplished via the open-source Tectonic Reconstruct ArcGIS tool. We find that restoration across the Gulf of California completely closes marine basins and their terrestrial predecessors between 6 and 9 Ma. Latest Miocene opening of these basins was coincident with a ~10° clockwise azimuthal change from 8 to 6 Ma in PAC-NAM relative motion, as revealed by the global plate circuit model. The

  13. Intermittent 1630 1220 Ma magmatism in central Mazatzal province: New geochronologic piercing points and some tectonic implications

    NASA Astrophysics Data System (ADS)

    Tapani Rämö, O.; McLemore, Virginia T.; Hamilton, Michael A.; Kosunen, Paula J.; Heizler, Matt; Haapala, Ilmari

    2003-04-01

    The northern Burro Mountains in southwestern New Mexico reveal three distinct, intimately juxtaposed Mesoproterozoic magmatic suites in southern Laurentia. At 1633 Ma, the newly formed Mazatzal crust was intruded by tholeiitic diabase with a depleted-mantle type Nd isotope composition but with enriched incompatible trace element abundances. A potassic granite-minette suite was emplaced ca. 1460 Ma, and a tholeiitic A-type granite-anorthosite suite intruded ca. 1225 1220 Ma. The diabase-minette-anorthosite sequence and the associated silicic rocks record dominantly juvenile additions to the cratonic margin and imply subcontinental enrichment events ca. 1650 Ma (accretion), prior to 1460 Ma (potassic metasomatism), and ca. 1220 Ma (magmatic underplating). The latter two may have been controlled by a major transcurrent structure along the south margin of Laurentia.

  14. Fermi-LAT detection of a very bright Gamma-ray Onset from the Galactic Nova ASASSN-16ma

    NASA Astrophysics Data System (ADS)

    Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay

    2016-11-01

    We report the detection of gamma-ray emission from ASASSN-16ma, spectroscopically classified as a classical nova (ATel #9669 and ATel #9678). Because of the close proximity to TCP J18102829-2729590 (separated from ASAS-SN 16ma by 2.5 degrees), ASASSN-16ma is under our Fermi ToO monitoring triggered for TCP J18102829-2729590 since 2016-10-25 (ATel #9699).

  15. 42 CFR 422.458 - Risk sharing with regional MA organizations for 2006 and 2007.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... that count toward allowable costs. Target amount means, with respect to an MA regional plan offered by...) Adjustment of payment—(1) No adjustment if allowable costs within 3 percent of target amount. If the... target amount for the plan and year, there will be no payment adjustment under this section for the...

  16. Gun Carrying by High School Students in Boston, MA: Does Overestimation of Peer Gun Carrying Matter?

    ERIC Educational Resources Information Center

    Hemenway, David; Vriniotis, Mary; Johnson, Renee M.; Miller, Matthew; Azrael, Deborah

    2011-01-01

    This paper investigates: (1) whether high school students overestimate gun carrying by their peers, and (2) whether those students who overestimate peer gun carrying are more likely to carry firearms. Data come from a randomly sampled survey conducted in 2008 of over 1700 high school students in Boston, MA. Over 5% of students reported carrying a…

  17. Fabrication Technological Development of the Oxide Dispersion Strengthened Alloy MA957 for Fast Reactor Applications

    SciTech Connect

    Hamilton, Margaret L.; Gelles, David S.; Lobsinger, Ralph J.; Johnson, Gerald D.; Brown, W. F.; Paxton, Michael M.; Puigh, Raymond J.; Eiholzer, Cheryl R.; Martinez, C.; Blotter, M. A.

    2000-02-28

    A significant amount of effort has been devoted to determining the properties and understanding the behavior of the alloy MA957 to define its potential usefulness as a cladding material in the fast breeder reactor program. The numerous characterization and fabrication studies that were conducted are documented in this report.

  18. Direct and airborne contact dermatitis in a beekeeper from the Małopolska region.

    PubMed

    Basista, Katarzyna

    2012-09-01

    The paper describes an atypical case of simultaneous airborne and direct contact dermatitis in a beekeeper from the Małopolska region. This is the third such case described in a beekeeper in the world and the first in Poland. I suggest that propolis should be regarded as both a direct and airborne contact allergen in beekeepers.

  19. Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics

    PubMed Central

    Jin, Mingyue; Pomp, Oz; Shinoda, Tomoyasu; Toba, Shiori; Torisawa, Takayuki; Furuta, Ken’ya; Oiwa, Kazuhiro; Yasunaga, Takuo; Kitagawa, Daiju; Matsumura, Shigeru; Miyata, Takaki; Tan, Thong Teck; Reversade, Bruno; Hirotsune, Shinji

    2017-01-01

    Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly. Although p80 plays critical roles during brain development, the underlying mechanisms remain predominately unknown. Here, we demonstrate that p80 regulates microtubule (MT) remodeling in combination with NuMA (nuclear mitotic apparatus protein) and cytoplasmic dynein. We show that p80 shuttles between the nucleus and spindle pole in synchrony with the cell cycle. Interestingly, this striking feature is shared with NuMA. Importantly, p80 is essential for aster formation and maintenance in vitro. siRNA-mediated depletion of p80 and/or NuMA induced abnormal mitotic phenotypes in cultured mouse embryonic fibroblasts and aberrant neurogenesis and neuronal migration in the mouse embryonic brain. Importantly, these results were confirmed in p80-mutant harboring patient-derived induced pluripotent stem cells and brain organoids. Taken together, our findings provide valuable insights into the pathogenesis of severe microlissencephaly, in which p80 and NuMA delineate a common pathway for neurogenesis and neuronal migration via MT organization at the centrosome/spindle pole. PMID:28079116

  20. MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14

    NASA Technical Reports Server (NTRS)

    1963-01-01

    MA-9 ASTRONAUT L. GORDON COOPER LEAVES TRANSFER VAN AT LAUNCH COMPLEX 14 S-63-6247 P-07136, ARCHIVE-03808 Astronaut L. Gordon Cooper, Jr., leaves the transfer van at Pad #14 for his ride up the gantry elevator to the 11th deck where he will be inserted into the spacecraft for his 22-orbit mission.

  1. MA-9 ASTRONAUT GORDON COOPER EXPLAINS CAMERA TO BACKUP PILOT ALAN SHEPARD

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Astronaut L. Gordon Cooper explains the 16MM handheld spacecraft camera to his back-up pilot Astronaut Alan Shepard. The camera designed by J. R. Hereford, McDonnell Aircraft Corp., will be used by Cooper during the MA-9 mission.

  2. 76 FR 18778 - Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... National Park Service Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory..., 86 Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on May...

  3. 76 FR 8768 - Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... National Park Service Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory... Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on March...

  4. 76 FR 44606 - Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... National Park Service Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory.... 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on September...

  5. 76 FR 66082 - Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-25

    ... National Park Service Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory... Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on...

  6. 75 FR 34479 - Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... National Park Service Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory... Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on July...

  7. 75 FR 5622 - Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission AGENCY.... App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on March 22, 2010 at 1...

  8. 75 FR 77900 - Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... National Park Service Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory... Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on...

  9. 75 FR 48990 - Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... Cape Cod National Seashore; South Wellfleet, MA; Cape Cod National Seashore Advisory Commission AGENCY.... App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on September 13, 2010, at 1...

  10. 75 FR 63854 - Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... National Park Service Cape Cod National Seashore, South Wellfleet, MA; Cape Cod National Seashore Advisory... Stat. 770, 5 U.S.C. App 1, Section 10) of a meeting of the Cape Cod National Seashore Advisory Commission. DATES: The meeting of the Cape Cod National Seashore Advisory Commission will be held on...

  11. 46. Quincy, MA, BO37, Launch Area, Underground Missile Storage Structure, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Quincy, MA, BO-37, Launch Area, Underground Missile Storage Structure, interior view of elevator system with overhead doors in open position and hydraulic shaft in left foreground VIEW WEST - NIKE Missile Battery PR-79, Launch Area, East Windsor Road south of State Route 101, Foster, Providence County, RI

  12. MaRIE: A facility for time-dependent materials science at the mesoscale

    SciTech Connect

    Barnes, Cris William; Kippen, Karen Elizabeth

    2015-02-11

    To meet new and emerging national security issues the Laboratory is stepping up to meet another grand challenge—transitioning from observing to controlling a material’s performance. This challenge requires the best of experiment, modeling, simulation, and computational tools. MaRIE is the Laboratory’s proposed flagship experimental facility intended to meet the challenge.

  13. A Content Analysis of the TEFL M.A. Entrance Examinations (Case Study: Majors Courses)

    ERIC Educational Resources Information Center

    Razmjoo, Seyyed Ayatollah; Heydari Tabrizi, Hossein

    2010-01-01

    The MA Entrance Examinations (MAEE) held in Iran since 1990 are frequently criticized as being invalid, unstandardized exams with lots of problem in terms of principles of testing in general and test construction in particular (for instance, Jafarpur, 1996). To make sound judgments about such objections, the present study dealt with a content…

  14. 46 CFR 308.549 - Application for appointment of Cargo Underwriting Agent, Form MA-319.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.549 Application for appointment of Cargo Underwriting Agent, Form MA-319. Any domestic insurance company authorized to do a marine insurance business in any State of the United States may apply for appointment as a Cargo Underwriting...

  15. 46 CFR 308.549 - Application for appointment of Cargo Underwriting Agent, Form MA-319.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Iv-General § 308.549 Application for appointment of Cargo Underwriting Agent, Form MA-319. Any domestic insurance company authorized to do a marine insurance business in any State of the United States may apply for appointment as a Cargo Underwriting...

  16. The physics of spinal manipulation. Part I. The myth of F = ma.

    PubMed

    Haas, M

    1990-05-01

    The product of the adjusting physician's mass and acceleration does not quantify the adjustive force as popularly believed, an error stemming from a misunderstanding of Newton's second law. In this paper, a gedanken experiment illustrates the misapplication of F = ma and suggests that the adjustive force depends on the impact velocity, mass of the doctor, and intrinsic physical properties of the doctor and patient.

  17. 42 CFR 422.324 - Payments to MA organizations for graduate medical education costs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... residents spend in non-hospital provider settings such as freestanding clinics, nursing homes, and... medical education payments if all of the following conditions are met: (1) The resident spends his or her... the total number of individuals enrolled in the MA organization. (e) Direct graduate medical...

  18. 42 CFR 422.314 - Special rules for beneficiaries enrolled in MA MSA plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Special rules for beneficiaries enrolled in MA MSA plans. 422.314 Section 422.314 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE ADVANTAGE PROGRAM Payments...

  19. 33 CFR 80.115 - Portland Head, ME to Cape Ann, MA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Portland Head, ME to Cape Ann, MA. 80.115 Section 80.115 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.115 Portland Head, ME to Cape...

  20. 78 FR 66983 - Massachusetts Disaster #MA-00056 Declaration of Economic Injury

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... ADMINISTRATION Massachusetts Disaster MA-00056 Declaration of Economic Injury AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Economic Injury Disaster Loan (EIDL) declaration... the Administrator's EIDL declaration, applications for economic injury disaster loans may be filed...