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Sample records for 15n-leu incorporation fidelity

  1. Incorporating medium fidelity simulation in a practical nurse education program.

    PubMed

    Cunningham, Donna D

    2010-01-01

    We frequently hear the word simulation in nursing educatioh. Research has been done on the use of high fidelity simulation in registered nursing programs. High fidelity simulators are expensive and require more than one faculty to facilitate. The question remains: Does every nursing program require a high fidelity simulation laboratory? This article will define the three levels of fidelity and describe the incorporation of a medium fidelity simulation into a practical nursing program and will describe the benefits of simulation use. The article will assist the faculty and students new to simulation, and allow them to choose the equipment and scenarios that will be most advantageous for their individual programs. The choice of equipment, scenarios, and fidelity often depends upon the space, time, funds, and faculty available. Simulation adds an important component to nursing education. Using simulation wisely helps students practice in a controlled environment without danger to living patients. The lessons learned will someday play into a "life or death" scenario, and the patient will not be a simulation mannequin.

  2. Efficient and high fidelity incorporation of dye-terminators by a novel archaeal DNA polymerase mutant.

    PubMed

    Arezi, Bahram; Hansen, Connie J; Hogrefe, Holly H

    2002-09-27

    We examined the molecular basis of ddNTP selectivity in archaeal family B DNA polymerases by randomly mutagenizing the gene encoding Thermococcus sp. JDF-3 DNA polymerase and screening mutant libraries for improved ddNTP incorporation. We identified two mutations, P410L and A485T, that improved ddNTP uptake, suggesting the contribution of P410 and A485 to ddNTP/dNTP selectivity in archaeal DNA polymerases. The importance of A485 was identified previously in mutagenesis studies employing Pfu (A486) and Vent (A488) DNA polymerases, while the contribution of P410 to ddNTP/dNTP selectivity has not been reported. We demonstrate that a combination of mutations (P410L/A485T) has an additive effect in improving ddNTP incorporation by a total of 250-fold. To assess the usefulness of the JDF-3 P410L/A485T in fluorescent-sequencing applications, we compared the archaeal mutant to Taq F667Y with respect to fidelity and kinetic parameters for DNA and dye-ddNTPs. Although the Taq F667Y and JDF-3 P410L/A485T mutants exhibit similar K(m) and V(max) values for dye-ddNTPs in single-base extension assays, the archaeal mutant exhibits higher fidelity due to a reduced tendency to form certain (ddG:dT, ddT:dC) mispairs. DNA polymerases exhibiting higher insertion fidelity are expected to provide greater accuracy in SNP frequency determinations by single-base extension and in multiplex minisequencing assays.

  3. How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.

    PubMed

    Wu, Wen-Jin; Su, Mei-I; Wu, Jian-Li; Kumar, Sandeep; Lim, Liang-Hin; Wang, Chun-Wei Eric; Nelissen, Frank H T; Chen, Ming-Chuan Chad; Doreleijers, Jurgen F; Wijmenga, Sybren S; Tsai, Ming-Daw

    2014-04-02

    A dogma for DNA polymerase catalysis is that the enzyme binds DNA first, followed by MgdNTP. This mechanism contributes to the selection of correct dNTP by Watson-Crick base pairing, but it cannot explain how low-fidelity DNA polymerases overcome Watson-Crick base pairing to catalyze non-Watson-Crick dNTP incorporation. DNA polymerase X from the deadly African swine fever virus (Pol X) is a half-sized repair polymerase that catalyzes efficient dG:dGTP incorporation in addition to correct repair. Here we report the use of solution structures of Pol X in the free, binary (Pol X:MgdGTP), and ternary (Pol X:DNA:MgdGTP with dG:dGTP non-Watson-Crick pairing) forms, along with functional analyses, to show that Pol X uses multiple unprecedented strategies to achieve the mutagenic dG:dGTP incorporation. Unlike high fidelity polymerases, Pol X can prebind purine MgdNTP tightly and undergo a specific conformational change in the absence of DNA. The prebound MgdGTP assumes an unusual syn conformation stabilized by partial ring stacking with His115. Upon binding of a gapped DNA, also with a unique mechanism involving primarily helix αE, the prebound syn-dGTP forms a Hoogsteen base pair with the template anti-dG. Interestingly, while Pol X prebinds MgdCTP weakly, the correct dG:dCTP ternary complex is readily formed in the presence of DNA. H115A mutation disrupted MgdGTP binding and dG:dGTP ternary complex formation but not dG:dCTP ternary complex formation. The results demonstrate the first solution structural view of DNA polymerase catalysis, a unique DNA binding mode, and a novel mechanism for non-Watson-Crick incorporation by a low-fidelity DNA polymerase.

  4. Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.

    PubMed

    Liu, Xinran; Yang, Xiaorong; Lee, Cheri A; Moustafa, Ibrahim M; Smidansky, Eric D; Lum, David; Arnold, Jamie J; Cameron, Craig E; Boehr, David D

    2013-11-08

    All viral RNA-dependent RNA polymerases (RdRps) have a conserved structural element termed motif D. Studies of the RdRp from poliovirus (PV) have shown that a conformational change of motif D leads to efficient and faithful nucleotide addition by bringing Lys-359 into the active site where it serves as a general acid. The RdRp of the Sabin I vaccine strain has Thr-362 changed to Ile. Such a drastic change so close to Lys-359 might alter RdRp function and contribute in some way to the attenuated phenotype of Sabin type I. Here we present our characterization of the T362I RdRp. We find that the T362I RdRp exhibits a mutator phenotype in biochemical experiments in vitro. Using NMR, we show that this change in nucleotide incorporation fidelity correlates with a change in the structural dynamics of motif D. A recombinant PV expressing the T362I RdRp exhibits normal growth properties in cell culture but expresses a mutator phenotype in cells. For example, the T362I-containing PV is more sensitive to the mutagenic activity of ribavirin than wild-type PV. Interestingly, the T362I change was sufficient to cause a statistically significant reduction in viral virulence. Collectively, these studies suggest that residues of motif D can be targeted when changes in nucleotide incorporation fidelity are desired. Given the observation that fidelity mutants can serve as vaccine candidates, it may be possible to use engineering of motif D for this purpose.

  5. Kinetics of deoxy-CTP incorporation opposite a dG-C8-N-2-aminofluorene adduct by a high-fidelity DNA polymerase.

    PubMed

    Burnouf, Dominique Y; Wagner, Jérôme E

    2009-03-06

    The model carcinogen N-2-acetylaminofluorene covalently binds to the C8 position of guanine to form two adducts, the N-(2'-deoxyguanosine-8-yl)-aminofluorene (G-AF) and the N-2-(2'-deoxyguanosine-8-yl)-acetylaminofluorene (G-AAF). Although they are chemically closely related, their biological effects are strongly different and they are processed by different damage tolerance pathways. G-AF is bypassed by replicative and high-fidelity polymerases, while specialized polymerases ensure synthesis past of G-AAF. We used the DNA polymerase I fragment of a Bacillus stearothermophilus strain as a model for a high-fidelity polymerase to study the kinetics of incorporation of deoxy-CTP (dCTP) opposite a single G-AF. Pre-steady-state kinetic experiments revealed a drastic reduction in dCTP incorporation performed by the G-AF-modified ternary complex. Two populations of these ternary complexes were identified: (i) a minor productive fraction (20%) that readily incorporates dCTP opposite the G-AF adduct with a rate similar to that measured for the adduct-free ternary complexes and (ii) a major fraction of unproductive complexes (80%) that slowly evolve into productive ones. In the light of structural data, we suggest that this slow rate reflects the translocation of the modified base within the active site, from the pre-insertion site into the insertion site. By making this translocation rate limiting, the G-AF lesion reveals a novel kinetic step occurring after dNTP binding and before chemistry.

  6. Incorporating in situ habitat patchiness in site selection models reveals that site fidelity is not always a consequence of animal choice.

    PubMed

    Martinez, Aline S; Queiroz, Eduardo V; Bryson, Mitch; Byrne, Maria; Coleman, Ross A

    2017-03-25

    1.Understanding site fidelity is important in animal ecology, but evidence is lacking that this behaviour is due to an animal choosing a specific location. To discern site selection behaviour it is necessary to consider the spatial distribution of habitats that animals can occupy within a landscape. Tracking animals and defining clear habitat boundaries, however, is often difficult. 2.We use in situ habitat distribution data and animal movement simulations to investigate behavioural choice in site fidelity patterns. We resolved the difficulty of gathering data by working with intertidal rock pool systems, which are of manageable size and where boundaries are easy to define. Movements of the intertidal starfish Parvulastra exigua were quantified to test the hypotheses that (1) this species displays fidelity to a particular rock pool and that (2) rock pool fidelity is due to site selection behaviour. Observed patterns of individuals (n=10 starfish) returning to a previously occupied rock pool (n = 5 pools per location) were tested against an expected null distribution generated through simulations of random movements within their natural patchy environment. 3. Starfish exhibited site selection behaviour at only one location even though site fidelity was high (av. 7.4 starfish out of 10 found in test pools) in 2 of the 3 locations. The random chance of a starfish returning to a pool increased 67% for each metre further a rock pool was from the original pool, and 120% for each square metre increase in surface area of an original pool. The decision of returning to an original rock pool was influenced by food availability. When microalgal cover was > 60%, there was a ~ 50% chance of animals staying faithful to that pool. 4. Our results show the importance to consider spatial distribution of habitats in understanding patterns of animal movement associated with animal choices and site fidelity. Returning to a particular place does not necessarily mean that an

  7. Fidelity to Theory in PA Intervention Research.

    PubMed

    Keller, Colleen; Fleury, Julie; Sidani, Souraya; Ainsworth, Barbara

    2009-04-01

    Research using theory-based interventions to promote regular physical activity (PA) has increased substantially over the past decade. The purpose of this article is to provide a review and summary of PA intervention research specific to fidelity to intervention theory, providing an overview of the concept of fidelity to intervention theory, defining the evaluative components of fidelity: (a) conceptualization of the problem, (b) operationalization of the theory, (c) specification of mediating processes, and (d) specification of outcome variables. Using journal scans and computerized literature database searches, the authors identified 470 PA activity intervention studies that incorporated a theoretical perspective. A validity framework explicated by was used to summarize intervention research in light of fidelity to intervention theory. In all, 15 intervention studies met the inclusion criteria and were incorporated into the review. Theoretical models for health behavior change, including social cognitive theory (SCT), cognitive behavioral theory (CBT), the transtheoretical model (TTM, the TTM combined with SCT), the reversal theory (theory of psychological reversals), and the disconnected values theory, were used as a basis for intervention design and evaluation.

  8. Sub-Fidelity and Super-Fidelity Between Gaussian States

    NASA Astrophysics Data System (ADS)

    Qi, Xiao-Fei; Wang, Li

    2015-09-01

    In this paper, we analyze the sub-fidelity and super-fidelity of an arbitrary pair of n-mode Gaussian states. Particularly, an explicit formula for the sub-fidelity and super-fidelity between any two-mode Gaussian states is obtained. Supported by Natural Science Foundation of China under Grant Nos. 11171249, 11201329, and Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi

  9. Astrocytes optimize synaptic fidelity

    NASA Astrophysics Data System (ADS)

    Nadkarni, Suhita; Jung, Peter; Levine, Herbert

    2007-03-01

    Most neuronal synapses in the central nervous system are enwrapped by an astrocytic process. This relation allows the astrocyte to listen to and feed back to the synapse and to regulate synaptic transmission. We combine a tested mathematical model for the Ca^2+ response of the synaptic astrocyte and presynaptic feedback with a detailed model for vesicle release of neurotransmitter at active zones. The predicted Ca^2+ dependence of the presynaptic synaptic vesicle release compares favorably for several types of synapses, including the Calyx of Held. We hypothesize that the feedback regulation of the astrocyte onto the presynaptic terminal optimizes the fidelity of the synapse in terms of information transmission.

  10. RTI Fidelity of Implementation Rubric

    ERIC Educational Resources Information Center

    National Center on Response to Intervention, 2014

    2014-01-01

    The Response to Intervention (RTI) Fidelity Rubric is for use by individuals who are responsible for monitoring school-level fidelity of RTI implementation. The rubric is aligned with the essential components of RTI and the infrastructure that is necessary for successful implementation. It is accompanied by a worksheet with guiding questions and…

  11. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta.

    PubMed

    Washington, M T; Johnson, R E; Prakash, S; Prakash, L

    1999-12-24

    The yeast RAD30 gene functions in error-free replication of UV-damaged DNA, and RAD30 encodes a DNA polymerase, pol eta, that has the ability to efficiently and correctly replicate past a cis-syn-thymine-thymine dimer in template DNA. To better understand the role of pol eta in damage bypass, we examined its fidelity and processivity on nondamaged DNA templates. Steady-state kinetic analyses of deoxynucleotide incorporation indicate that pol eta has a low fidelity, misincorporating deoxynucleotides with a frequency of about 10(-2) to 10(-3). Also pol eta has a low processivity, incorporating only a few nucleotides before dissociating. We suggest that pol eta's low fidelity reflects a flexibility in its active site rendering it more tolerant of DNA damage, while its low processivity limits its activity to reduce errors.

  12. Evidence, Fidelity, and Organisational Rationales: Multiple Uses of Motivational Interviewing in a Social Services Agency

    ERIC Educational Resources Information Center

    Björk, Alexander

    2016-01-01

    In discussions and empirical investigations of the implementation of evidence-based interventions there is often a narrow focus on treatment fidelity. Studying a social services agency trying to incorporate Motivational Interviewing (MI), commonly regarded as evidence-based, this paper problematises a one-sided attention to treatment fidelity by…

  13. Fidelity and fidelity susceptibility of pulses in dispersive media

    SciTech Connect

    Wang Ligang; Gu Shijian

    2009-07-15

    Motivated by the growing importance of the fidelity and fidelity susceptibility (FS) in quantum critical phenomena, we use these concepts to describe the pulse propagation inside the dispersive media. It is found that there is a dramatic change in the fidelity and the FS of the pulse at a critical propagation distance inside a dispersive medium, and whether such a dramatic change for a light pulse occurs or not strongly depends on both the dispersive strength of the media and the pulse property. We study in detail about the changes in the fidelity and the FS for both a smooth and a truncated Gaussian pulse through the abnormal and normal dispersive media, where the group velocities are well defined. Our results show that both the fidelity and the FS could be very useful to determine whether the pulse is completely distorted or not at the critical distance; therefore it would be very helpful to find the maximal effective propagation region of the pulse's group velocity, in terms of the changes in the pulse's fidelity and FS.

  14. Promotoras' roles in integrative validity and treatment fidelity efforts in randomized controlled trials.

    PubMed

    Keller, Colleen; Records, Kathie; Coe, Kathryn; Ainsworth, Barbara; Vega López, Sonia; Nagle-Williams, Allison; Permana, Paska

    2012-01-01

    Promotoras from the communities in which interventions are implemented can be effective contributors to validity and fidelity efforts. This article describes a 48-week randomized controlled trial Madres para la Salud (Mothers for Health) and illustrates the use of promotoras as collaborative members of the research team to contribute to attaining integrative validity and treatment fidelity. Madres para la Salud implements a culturally tailored physical activity program to effect changes in body fat, systemic and fat tissue inflammation, and depression symptoms. The significance of Madres para la Salud treatment validity and fidelity processes includes cultural tailoring of a social support intervention, and a promotora model to incorporate initial and ongoing fidelity monitoring.

  15. Intervention Research: The Importance of Fidelity Measurement

    ERIC Educational Resources Information Center

    Wolery, Mark

    2011-01-01

    In this commentary, the issue of fidelity assessment is addressed as it relates to Strain and Bovey's article (2011). Four reasons are provided for measuring fidelity in intervention studies. Measuring fidelity (a) potentially allows investigators to document the findings were not due to the lack of fidelity in a study; (b) presents information…

  16. Curriculum Fidelity and Factors Affecting Fidelity in the Turkish Context

    ERIC Educational Resources Information Center

    Bumen, Nilay T.; Cakar, Esra; Yildiz, Derya G.

    2014-01-01

    Although a centralist education system is in place in Turkey, studies show that while implementing the curriculum developed by the Ministry of Education, teachers make changes based on their own preferences or depending on students. Curriculum fidelity can be defined as the degree to which teachers or stakeholders abide by a curriculum's original…

  17. Site fidelity, mate fidelity, and breeding dispersal in American kestrels

    USGS Publications Warehouse

    Steenhof, K.; Peterson, B.E.

    2009-01-01

    We assessed mate fidelity, nest-box fidelity, and breeding dispersal distances of American Kestrels (falco sparverius) nesting in boxes in southwestern Idaho from 1990 through 2006. Seventy-seven percent of boxes had different males and 87% had different females where nest-box occupants were identified in consecutive years. High turnover rates were partly a result of box-switching. Forty-eight percent of males and 58% of females that nested within the study area in successive years used different boxes. The probability of changing boxes was unrelated to gender, nesting success in the prior year, or years of nesting experience. Breeding dispersal distances for birds that moved to different boxes averaged 2.2 km for males (max = 22 km) and 3.2 km for females (max = 32 km). Approximately 70% of birds that nested in consecutive years on the study area had a different mate in the second year. Mate fidelity was related to box fidelity but not to prior nesting success or years of nesting experience. Mate changes occurred 32% of the time when the previous mate was known to be alive and nesting in the area. Kestrels that switched mates and boxes did not improve or decrease their subsequent nesting success. Kestrels usually switched to mates with less experience and lower lifetime productivity than their previous mates. The costs of switching boxes and mates were low, and there were no obvious benefits to fidelity. The cost of "waiting" for a previous mate that might have died could be high in species with high annual mortality.

  18. Training Teachers to use Evidence-Based Practices for Autism: Examining Procedural Implementation fidelity.

    PubMed

    Stahmer, Aubyn C; Reed, Sarah; Lee, Ember; Reisinger, Erica M; Connell, James E; Mandell, David S

    2015-02-01

    The purpose of this study was to examine the extent to which public school teachers implemented evidence-based interventions for students with autism in the way these practices were designed. Evidence-based practices for students with autism are rarely incorporated into community settings, and little is known about the quality of implementation. An indicator of intervention quality is procedural implementation fidelity (the degree to which a treatment is implemented as prescribed). Procedural fidelity likely affects student outcomes. This project examined procedural implementation fidelity of three evidence-based practices used in a randomized trial of a comprehensive program for students with autism in partnership with a large, urban school district. Results indicate that teachers in public school special education classrooms can learn to implement evidence-based strategies; however they require extensive training, coaching, and time to reach and maintain moderate procedural implementation fidelity. Procedural fidelity over time, and across intervention strategies is examined.

  19. Training Teachers to use Evidence-Based Practices for Autism: Examining Procedural Implementation fidelity

    PubMed Central

    Stahmer, Aubyn C.; Reed, Sarah; Lee, Ember; Reisinger, Erica M.; Connell, James E.; Mandell, David S.

    2014-01-01

    The purpose of this study was to examine the extent to which public school teachers implemented evidence-based interventions for students with autism in the way these practices were designed. Evidence-based practices for students with autism are rarely incorporated into community settings, and little is known about the quality of implementation. An indicator of intervention quality is procedural implementation fidelity (the degree to which a treatment is implemented as prescribed). Procedural fidelity likely affects student outcomes. This project examined procedural implementation fidelity of three evidence-based practices used in a randomized trial of a comprehensive program for students with autism in partnership with a large, urban school district. Results indicate that teachers in public school special education classrooms can learn to implement evidence-based strategies; however they require extensive training, coaching, and time to reach and maintain moderate procedural implementation fidelity. Procedural fidelity over time, and across intervention strategies is examined. PMID:25593374

  20. Intermediate Fidelity Closed Brayton Cycle Power Conversion Model

    NASA Technical Reports Server (NTRS)

    Lavelle, Thomas M.; Khandelwal, Suresh; Owen, Albert K.

    2006-01-01

    This paper describes the implementation of an intermediate fidelity model of a closed Brayton Cycle power conversion system (Closed Cycle System Simulation). The simulation is developed within the Numerical Propulsion Simulation System architecture using component elements from earlier models. Of particular interest, and power, is the ability of this new simulation system to initiate a more detailed analysis of compressor and turbine components automatically and to incorporate the overall results into the general system simulation.

  1. Extending the Conceptualization of Listening Fidelity

    ERIC Educational Resources Information Center

    Fitch-Hauser, Margaret; Powers, William G.; O'Brien, Kelley; Hanson, Scott

    2007-01-01

    An exploration of variables potentially related to Listening Fidelity (LF) was conducted through two separate studies. Study 1 indicated that when the potential fidelity of the stimulus message was varied as a function of the number of words and time length, the message with lowest potential fidelity produced significantly lower LF than either the…

  2. Implementers' Perspectives on Fidelity of Implementation.

    PubMed

    Cutbush, Stacey; Gibbs, Deborah; Krieger, Kathleen; Clinton-Sherrod, Monique; Miller, Shari

    2017-03-01

    Fidelity of implementation is an essential factor in realizing outcomes of evidence-based interventions. Yet perspectives vary on the degree to which fidelity is necessary or desirable, implementers may receive limited guidance on fidelity, and research on implementers' understanding and operationalization of fidelity is lacking. We conducted key informant interviews with 20 individuals who implemented an evidence-based teen dating violence prevention curriculum in seven sites. Interviews addressed how implementers defined fidelity and the adaptations they made in implementing the curriculum. Although all implementers reported delivering the curriculum with fidelity, their definitions of fidelity varied. Most defined fidelity in terms of adherence to the published curriculum, although definitions sometimes allowed modifications of pedagogy or adding or subtracting materials. A smaller group of implementers defined fidelity in terms of their perceptions of the curriculum's core messages. All implementers described variations from the published curriculum, which were frequently inconsistent with their own definitions of fidelity. Implementers committed to the value of implementation with fidelity may need support in its definition and application. Developers can support implementers by communicating program theory in terms that implementers will understand, clarifying expectations for fidelity and allowable adaptations, and codifying lessons learned from previous implementation.

  3. Optimizing image fidelity with arrays

    NASA Astrophysics Data System (ADS)

    Corder, Stuartt Allan

    2009-11-01

    Through simulations, I have investigated the limitations imposed upon the image fidelity of interferometric observations by primary beam errors. Significant antenna surface and pointing errors lead to the greatest reduction in fidelity for most cases, but, when present, imaginary beam components dominate the degradation. Beam errors were addressed by optimizing the antenna surfaces and aligning the optics and then determining baseline based primary beams. Methods for applying these measured patterns to actual data were discussed. Pointing errors were reduced by improving the fit to the pointing model. Further reduction was achieved by integrating the use of optical pointing observations into standard radio observing. The greatest benefit was seen during daytime observations, but general reduction in pointing error was seen.The dense uv-coverage of the Combined Array for Research in Millimeter-wave Astronomy (CARMA) coupled with the techniques described above make it an ideal instrument for imaging extended regions with high fidelity. The NGC 7538 star-forming cloud contains dense peaks, many high-mass stars and associated accretion disks, and multiple outflows. I obtained CARMA images at the requisite fidelity, employing the above techniques. These mosaiced, spectral-line, and 3-mm band continuum observations provide a clearer picture of the bulk morphology of the region and the fine-scale structures within it than has hitherto been possible. For the first time in the region, infall signatures were found towards two sources, allowing comparison of the infall and outflow mass and verifying that significant accretion (>10-4M⊙ yr-1) continues well into the stage where a massive protostar has formed. One of the sources, NGC 7538IRS1, shows one of the few definitive signatures of an inverse PCygni profile towards a massive protostar. Three outflows were found centered on sources that are separated by 10,000-20,000 AU in projection. The calculated energy injection rate

  4. Differences in observers' and teachers' fidelity assessments.

    PubMed

    Hansen, William B; Pankratz, Melinda M; Bishop, Dana C

    2014-10-01

    As evidence-based programs become disseminated, understanding the degree to which they are implemented with fidelity is crucial. This study tested the validity of fidelity ratings made by observers versus those made by teachers. We hypothesized that teachers' reports about fidelity would have a positivity bias when compared to observers' reports. Further, we hypothesized that there would generally be low correspondence between teachers' and observers' ratings of fidelity. We examined teachers' and observers' ratings as they were related to mediating variables targeted for change by the intervention. Finally, we examined the role that years of teaching experience played in achieving fidelity. Eighteen teachers and four research assistants participated in this project as raters. Teachers made video recordings of their implementation of All Stars and completed fidelity assessment forms. Trained observers independently completed parallel forms for 215 sampled classroom sessions. Both teachers and observers rated adherence, quality of delivery, attendance, and participant engagement. Teachers made more positive fidelity ratings than did observers. With the exception of ratings for attendance, teachers and observers failed to agree on fidelity ratings. Observers' ratings were significantly related to students' pretest assessments of targeted program mediators. That observers' ratings were related to students' pretest scores, suggests it is easier to teach well when students are predisposed to program success. Teachers' ratings were infrequently related to mediators, but when they were, the relationship was counterintuitive. Experienced teachers taught with greater fidelity than novice teachers. While possibly inflated and inaccurate, gathering fidelity assessments from teachers may sensitize them to issues of fidelity as a result of requiring form completion. Assessing fidelity through observers' ratings of video recordings has significant merit. As a longterm investment

  5. Entropy Involved in Fidelity of DNA Replication

    PubMed Central

    Arias-Gonzalez, J. Ricardo

    2012-01-01

    Information has an entropic character which can be analyzed within the framework of the Statistical Theory in molecular systems. R. Landauer and C.H. Bennett showed that a logical copy can be carried out in the limit of no dissipation if the computation is performed sufficiently slowly. Structural and recent single-molecule assays have provided dynamic details of polymerase machinery with insight into information processing. Here, we introduce a rigorous characterization of Shannon Information in biomolecular systems and apply it to DNA replication in the limit of no dissipation. Specifically, we devise an equilibrium pathway in DNA replication to determine the entropy generated in copying the information from a DNA template in the absence of friction. Both the initial state, the free nucleotides randomly distributed in certain concentrations, and the final state, a polymerized strand, are mesoscopic equilibrium states for the nucleotide distribution. We use empirical stacking free energies to calculate the probabilities of incorporation of the nucleotides. The copied strand is, to first order of approximation, a state of independent and non-indentically distributed random variables for which the nucleotide that is incorporated by the polymerase at each step is dictated by the template strand, and to second order of approximation, a state of non-uniformly distributed random variables with nearest-neighbor interactions for which the recognition of secondary structure by the polymerase in the resultant double-stranded polymer determines the entropy of the replicated strand. Two incorporation mechanisms arise naturally and their biological meanings are explained. It is known that replication occurs far from equilibrium and therefore the Shannon entropy here derived represents an upper bound for replication to take place. Likewise, this entropy sets a universal lower bound for the copying fidelity in replication. PMID:22912695

  6. Fidelity Mechanisms of DNA Polymerase Alpha

    DTIC Science & Technology

    2008-07-23

    significantly lowers fidelity. Analogously, adding the equivalent of N-3 to low-fidelity benzimidazole -derived bases (generating 1-deazapurines... benzimidazole or to 1-deazapurines significantly decreases the rate at which pol α polymerizes the resulting bases opposite A, C, and G, while simultaneously

  7. What Is Essential in Developmental Evaluation? On Integrity, Fidelity, Adultery, Abstinence, Impotence, Long-Term Commitment, Integrity, and Sensitivity in Implementing Evaluation Models

    ERIC Educational Resources Information Center

    Patton, Michael Quinn

    2016-01-01

    Fidelity concerns the extent to which a specific evaluation sufficiently incorporates the core characteristics of the overall approach to justify labeling that evaluation by its designated name. Fidelity has traditionally meant implementing a model in exactly the same way each time following the prescribed steps and procedures. The essential…

  8. Physiological Based Simulator Fidelity Design Guidance

    NASA Technical Reports Server (NTRS)

    Schnell, Thomas; Hamel, Nancy; Postnikov, Alex; Hoke, Jaclyn; McLean, Angus L. M. Thom, III

    2012-01-01

    The evolution of the role of flight simulation has reinforced assumptions in aviation that the degree of realism in a simulation system directly correlates to the training benefit, i.e., more fidelity is always better. The construct of fidelity has several dimensions, including physical fidelity, functional fidelity, and cognitive fidelity. Interaction of different fidelity dimensions has an impact on trainee immersion, presence, and transfer of training. This paper discusses research results of a recent study that investigated if physiological-based methods could be used to determine the required level of simulator fidelity. Pilots performed a relatively complex flight task consisting of mission task elements of various levels of difficulty in a fixed base flight simulator and a real fighter jet trainer aircraft. Flight runs were performed using one forward visual channel of 40 deg. field of view for the lowest level of fidelity, 120 deg. field of view for the middle level of fidelity, and unrestricted field of view and full dynamic acceleration in the real airplane. Neuro-cognitive and physiological measures were collected under these conditions using the Cognitive Avionics Tool Set (CATS) and nonlinear closed form models for workload prediction were generated based on these data for the various mission task elements. One finding of the work described herein is that simple heart rate is a relatively good predictor of cognitive workload, even for short tasks with dynamic changes in cognitive loading. Additionally, we found that models that used a wide range of physiological and neuro-cognitive measures can further boost the accuracy of the workload prediction.

  9. Exploring Interprofessional Education through a High-Fidelity Human Patient Simulation Scenario: A Mixed Methods Study

    ERIC Educational Resources Information Center

    Rossler, Kelly Lynn

    2013-01-01

    High-fidelity human patient simulation has emerged as a valuable medium to reinforce educational content within programs of nursing. As simulation learning experiences have been identified as augmenting both didactic lecture content and clinical learning, these experiences have expanded to incorporate interprofessional education. Review of…

  10. The fidelity of adaptive phototaxis

    NASA Astrophysics Data System (ADS)

    Drescher, Knut; Tuval, Idan; Goldstein, Raymond

    2010-03-01

    Along the evolutionary path from single cells to multicellular organisms with a central nervous system are species of intermediate complexity which move in ways suggesting high-level coordination, yet have none. Instead, organisms within this category possess many autonomous cells which are endowed with programs that have evolved to achieve concerted responses to environmental stimuli. We examine the main features of the program underlying high-fidelity phototaxis in colonial algae which spin about a body-fixed axis as they swim. Using micromanipulation and particle image velocimetry of flagella-driven flows in Volvox carteri, we show that there is an adaptive response at the single-cell level that displays a pronounced maximum in its frequency dependence for periodic light signals. Moreover, the natural rotational frequency of the colony is tuned to match this optimal response. A hydrodynamic model of phototactic steering further shows that the phototactic ability decreases dramatically when the colony does not spin at its natural frequency, a result confirmed by phototaxis assays in which colony rotation was slowed by increasing the fluid viscosity.

  11. Fidelity imaging for atomic force microscopy

    NASA Astrophysics Data System (ADS)

    Ghosal, Sayan; Salapaka, Murti

    2015-01-01

    Atomic force microscopy is widely employed for imaging material at the nanoscale. However, real-time measures on image reliability are lacking in contemporary atomic force microscopy literature. In this article, we present a real-time technique that provides an image of fidelity for a high bandwidth dynamic mode imaging scheme. The fidelity images define channels that allow the user to have additional authority over the choice of decision threshold that facilitates where the emphasis is desired, on discovering most true features on the sample with the possible detection of high number of false features, or emphasizing minimizing instances of false detections. Simulation and experimental results demonstrate the effectiveness of fidelity imaging.

  12. Roseate Tern breeding dispersal and fidelity: Responses to two newly restored colony sites

    USGS Publications Warehouse

    Spendelow, Jeffrey A.; Monticelli, David; Nichols, James; Hines, James; Nisbet, Ian; Cormons, Grace; Hays, Helen; Hatch, Jeremy; Mostello, Carolyn

    2016-01-01

    We used 22 yr of capture–mark–reencounter (CMR) data collected from 1988 to 2009 on about 12,500 birds at what went from three to five coastal colony sites in Massachusetts, New York, and Connecticut, United States, to examine spatial and temporal variation in breeding dispersal/fidelity rates of adult Roseate Terns (Sterna dougallii). At the start of our study, Roseate Terns nested at only one site (Bird Island) in Buzzards Bay, Massachusetts, but two more sites in this bay (Ram and Penikese Islands) were subsequently recolonized and became incorporated into our CMR metapopulation study. We examined four major hypotheses about factors we thought might influence colony-site fidelity and movement rates in the restructured system. We found some evidence that colony-site fidelity remained higher at long-established sites compared with newer ones and that breeding dispersal was more likely to occur among nearby sites than distant ones. Sustained predation at Falkner Island, Connecticut, did not result in a sustained drop in fidelity rates of breeders. Patterns of breeding dispersal differed substantially at the two restored sites. The fidelity of Roseate Terns at Bird dropped quickly after nearby Ram was recolonized in 1994, and fidelity rates for Ram soon approached those for Bird. After an oil spill in Buzzards Bay in April 2003, hazing (deliberate disturbance) of the terns at Ram prior to the start of egg-laying resulted in lowering of fidelity at this site, a decrease in immigration from Bird, and recolonization of Penikese by Roseate Terns. Annual fidelity rates at Penikese increased somewhat several years after the initial recolonization, but they remained much lower there than at all the other sites throughout the study period. The sustained high annual rates of emigration from Penikese resulted in the eventual failure of the restoration effort there, and in 2013, no Roseate Terns nested at this site.

  13. Enhancing pediatric clinical competency with high-fidelity simulation.

    PubMed

    Birkhoff, Susan D; Donner, Carol

    2010-09-01

    In today's tertiary pediatric hospital setting, the increased complexity of patient care demands seamless coordination and collaboration among multidisciplinary team members. In an effort to enhance patient safety, clinical competence, and teamwork, simulation-based learning has become increasingly integrated into pediatric clinical practice as an innovative educational strategy. The simulated setting provides a risk-free environment where learners can incorporate cognitive, psychomotor, and affective skill acquisition without fear of harming patients. One pediatric university hospital in Southeastern Pennsylvania has enhanced the traditional American Heart Association (AHA) Pediatric Advanced Life Support (PALS) course by integrating high-fidelity simulation into skill acquisition, while still functioning within the guidelines and framework of the AHA educational standards. However, very little research with reliable standardized testing methods has been done to measure the effect of simulation-based learning. This article discusses the AHA guidelines for PALS, evaluation of PALS and nursing clinical competencies, communication among a multidisciplinary team, advantages and disadvantages of simulation, incorporation of high-fidelity simulation into pediatric practice, and suggestions for future practice.

  14. Using branching simulations in treatment fidelity plans.

    PubMed

    Kovach, Christine R; Rababa, Mohammad

    2014-01-01

    The purpose of this article is to present a new approach to treatment fidelity using branching simulations. Branching simulations are case scenarios that require the user to generate a series of step-by-step decisions and actions. The user is given immediate feedback on the consequences of his or her decisions and actions. Branching simulations may be a particularly useful fidelity strategy for interventions that require clinical decision making represented in terms of a flow of critical thinking and action steps. Results of fidelity testing in the current study using branching simulations revealed that 15 (22%) of 67 interventionists scored below the study's a priori 80% criterion for full retraining and retesting. Thirty (45%) interventionists needed partial retraining in using specific components of the intervention. Potential threats to internal validity posed by inadequate or erroneous adherence to multicomponent intervention protocols can be decreased through treatment fidelity using branching simulations.

  15. Resourcefulness Training for Dementia Caregivers: Establishing Fidelity

    PubMed Central

    Zauszniewski, Jaclene A.; Lekhak, Nirmala; Burant, Christopher J.; Underwood, Patricia W.; Morris, Diana L.

    2016-01-01

    Providing care for an elder with dementia can produce extreme stress that adversely affects caregiver health. Learning to be resourceful, which involves practicing resourcefulness skills using a journal or voice recorder, may reduce caregiver stress. However, before testing the effectiveness of journaling and voice recording as resourcefulness training (RT) practice methods, intervention fidelity should first be established. This pilot trial with 63 women dementia caregivers examined the fidelity of journaling and voice recording and whether allowing a choice between the methods affected RT intervention fidelity. Following RT, Resourcefulness Scale scores were similar for journal and recorder methods but higher for caregivers in the choice versus random condition. Patterns of RT skill use documented in journals or recordings were similar for choice and random conditions and for journal and recorder methods. The results support the implementation fidelity of RT that allows caregivers to choose a method to reinforce their resourcefulness skills. PMID:27338751

  16. Average fidelity between random quantum states

    SciTech Connect

    Zyczkowski, Karol; Sommers, Hans-Juergen

    2005-03-01

    We analyze mean fidelity between random density matrices of size N, generated with respect to various probability measures in the space of mixed quantum states: the Hilbert-Schmidt measure, the Bures (statistical) measure, the measure induced by the partial trace, and the natural measure on the space of pure states. In certain cases explicit probability distributions for the fidelity are derived. The results obtained may be used to gauge the quality of quantum-information-processing schemes.

  17. A Parallel, High-Fidelity Radar Model

    DTIC Science & Technology

    2010-09-01

    UCRL # LLNL-CONF-454075 A Parallel, High-Fidelity Radar Model Matthew Horsley, Benjamin Fasenfest Lawrence Livermore National Laboratory...Network to a collision or satellite break-up event. A high fidelity physics-based radar simulator has been developed for Space Surveillance...applications. This simulator is designed in a modular fashion, where each module describes a particular physical process or radar function (radio wave

  18. An information theoretic approach to use high-fidelity codes to calibrate low-fidelity codes

    NASA Astrophysics Data System (ADS)

    Lewis, Allison; Smith, Ralph; Williams, Brian; Figueroa, Victor

    2016-11-01

    For many simulation models, it can be prohibitively expensive or physically infeasible to obtain a complete set of experimental data to calibrate model parameters. In such cases, one can alternatively employ validated higher-fidelity codes to generate simulated data, which can be used to calibrate the lower-fidelity code. In this paper, we employ an information-theoretic framework to determine the reduction in parameter uncertainty that is obtained by evaluating the high-fidelity code at a specific set of design conditions. These conditions are chosen sequentially, based on the amount of information that they contribute to the low-fidelity model parameters. The goal is to employ Bayesian experimental design techniques to minimize the number of high-fidelity code evaluations required to accurately calibrate the low-fidelity model. We illustrate the performance of this framework using heat and diffusion examples, a 1-D kinetic neutron diffusion equation, and a particle transport model, and include initial results from the integration of the high-fidelity thermal-hydraulics code Hydra-TH with a low-fidelity exponential model for the friction correlation factor.

  19. Challenges in the development of high-fidelity LWR core neutronics tools

    SciTech Connect

    Smith, K.; Forget, B.

    2013-07-01

    Modern computing has made possible the solution of extremely large-scale reactor simulations, and the literature has numerous examples of high-resolution methods (often Monte Carlo) applied to full-core reactor problems. However, there are currently no examples in the literature of application of such 'High-Fidelity' or 'First Principles' methods to operating Light Water Reactor (LWR) analysis. This paper seeks to remind code developers, project managers, and analysts of the many important aspects of LWR simulation that must be incorporated to produce truly high-fidelity analysis tools. The authors offer a monetary prize to the first person (or group) that successfully solves a new two-cycle operational PWR depletion benchmark problem using high-fidelity tools and demonstrates acceptable accuracy by comparison with measured operational plant data (open source) provided to the reactor analysis community. (authors)

  20. Isolation and characterization of transcription fidelity mutants.

    PubMed

    Strathern, Jeffrey N; Jin, Ding Jun; Court, Donald L; Kashlev, Mikhail

    2012-07-01

    Accurate transcription is an essential step in maintaining genetic information. Error-prone transcription has been proposed to contribute to cancer, aging, adaptive mutagenesis, and mutagenic evolution of retroviruses and retrotransposons. The mechanisms controlling transcription fidelity and the biological consequences of transcription errors are poorly understood. Because of the transient nature of mRNAs and the lack of reliable experimental systems, the identification and characterization of defects that increase transcription errors have been particularly challenging. In this review we describe novel genetic screens for the isolation of fidelity mutants in both Saccharomyces cerevisiae and Escherichia coli RNA polymerases. We obtained and characterized two distinct classes of mutants altering NTP misincorporation and transcription slippage both in vivo and in vitro. Our study not only validates the genetic schemes for the isolation of RNA polymerase mutants that alter fidelity, but also sheds light on the mechanism of transcription accuracy. This article is part of a Special Issue entitled: Chromatin in time and space.

  1. Hamiltonian Engineering for High Fidelity Quantum Operations

    NASA Astrophysics Data System (ADS)

    Ribeiro, Hugo; Baksic, Alexandre; Clerk, Aashish

    High-fidelity gates and operations are crucial to almost every aspect of quantum information processing. In recent experiments, fidelity is mostly limited by unwanted couplings with states living out of the logical subspace. This results in both leakage and phase errors. Here, we present a general method to deal simultaneously with both these issues and improve the fidelity of quantum gates and operations. Our method is applicable to a wide variety of systems. As an example, we can correct gates for superconducting qubits, improve coherent state transfer between a single NV centre electronic spin and a single nitrogen nuclear spin, improve control over a nuclear spin ensemble, etc. Our method is intimately linked to the Magnus expansion. By modifying the Magnus expansion of an initially given Hamiltonian Hi, we find analytically additional control Hamiltonians Hctrl such that Hi +Hctrl leads to the desired gate while minimizing both leakage and phase errors.

  2. Unified universal quantum cloning machine and fidelities

    SciTech Connect

    Wang Yinan; Shi Handuo; Xiong Zhaoxi; Jing Li; Mu Liangzhu; Ren Xijun; Fan Heng

    2011-09-15

    We present a unified universal quantum cloning machine, which combines several different existing universal cloning machines together, including the asymmetric case. In this unified framework, the identical pure states are projected equally into each copy initially constituted by input and one half of the maximally entangled states. We show explicitly that the output states of those universal cloning machines are the same. One importance of this unified cloning machine is that the cloning procession is always the symmetric projection, which reduces dramatically the difficulties for implementation. Also, it is found that this unified cloning machine can be directly modified to the general asymmetric case. Besides the global fidelity and the single-copy fidelity, we also present all possible arbitrary-copy fidelities.

  3. Physics Of Eclipsing Binaries. II. Toward the Increased Model Fidelity

    NASA Astrophysics Data System (ADS)

    Prša, A.; Conroy, K. E.; Horvat, M.; Pablo, H.; Kochoska, A.; Bloemen, S.; Giammarco, J.; Hambleton, K. M.; Degroote, P.

    2016-12-01

    The precision of photometric and spectroscopic observations has been systematically improved in the last decade, mostly thanks to space-borne photometric missions and ground-based spectrographs dedicated to finding exoplanets. The field of eclipsing binary stars strongly benefited from this development. Eclipsing binaries serve as critical tools for determining fundamental stellar properties (masses, radii, temperatures, and luminosities), yet the models are not capable of reproducing observed data well, either because of the missing physics or because of insufficient precision. This led to a predicament where radiative and dynamical effects, insofar buried in noise, started showing up routinely in the data, but were not accounted for in the models. PHOEBE (PHysics Of Eclipsing BinariEs; http://phoebe-project.org) is an open source modeling code for computing theoretical light and radial velocity curves that addresses both problems by incorporating missing physics and by increasing the computational fidelity. In particular, we discuss triangulation as a superior surface discretization algorithm, meshing of rotating single stars, light travel time effects, advanced phase computation, volume conservation in eccentric orbits, and improved computation of local intensity across the stellar surfaces that includes the photon-weighted mode, the enhanced limb darkening treatment, the better reflection treatment, and Doppler boosting. Here we present the concepts on which PHOEBE is built and proofs of concept that demonstrate the increased model fidelity.

  4. Fidelity susceptibility as holographic PV-criticality

    NASA Astrophysics Data System (ADS)

    Momeni, Davood; Faizal, Mir; Myrzakulov, Kairat; Myrzakulov, Ratbay

    2017-02-01

    It is well known that entropy can be used to holographically establish a connection among geometry, thermodynamics and information theory. In this paper, we will use complexity to holographically establish a connection among geometry, thermodynamics and information theory. Thus, we will analyze the relation among holographic complexity, fidelity susceptibility, and thermodynamics in extended phase space. We will demonstrate that fidelity susceptibility (which is the informational complexity dual to a maximum volume in AdS) can be related to the thermodynamical volume (which is conjugate to the cosmological constant in the extended thermodynamic phase space). Thus, this letter establishes a relation among geometry, thermodynamics, and information theory, using complexity.

  5. Quantum phase transition, quantum fidelity and fidelity susceptibility in the Yang-Baxter system

    NASA Astrophysics Data System (ADS)

    Hu, Taotao; Yang, Qi; Xue, Kang; Wang, Gangcheng; Zhang, Yan; Li, Xiaodan; Ren, Hang

    2017-01-01

    In this paper, we investigate the ground-state fidelity and fidelity susceptibility in the many-body Yang-Baxter system and analyze their connections with quantum phase transition. The Yang-Baxter system was perturbed by a twist of e^{iφ} at each bond, where the parameter φ originates from the q-deformation of the braiding operator U with q = e^{-iφ} (Jimbo in Yang-Baxter equations in integrable systems, World Scientific, Singapore, 1990), and φ has a physical significance of magnetic flux (Badurek et al. in Phys. Rev. D 14:1177, 1976). We test the ground-state fidelity related by a small parameter variation φ which is a different term from the one used for driving the system toward a quantum phase transition. It shows that ground-state fidelity develops a sharp drop at the transition. The drop gets sharper as system size N increases. It has been verified that a sufficiently small value of φ used has no effect on the location of the critical point, but affects the value of F(gc,φ) . The smaller the twist φ, the more the value of F(gc,φ) is close to 0. In order to avoid the effect of the finite value of φ, we also calculate the fidelity susceptibility. Our results demonstrate that in the Yang-Baxter system, the quantum phase transition can be well characterized by the ground-state fidelity and fidelity susceptibility in a special way.

  6. Derivation Of Probabilistic Damage Definitions From High Fidelity Deterministic Computations

    SciTech Connect

    Leininger, L D

    2004-10-26

    This paper summarizes a methodology used by the Underground Analysis and Planning System (UGAPS) at Lawrence Livermore National Laboratory (LLNL) for the derivation of probabilistic damage curves for US Strategic Command (USSTRATCOM). UGAPS uses high fidelity finite element and discrete element codes on the massively parallel supercomputers to predict damage to underground structures from military interdiction scenarios. These deterministic calculations can be riddled with uncertainty, especially when intelligence, the basis for this modeling, is uncertain. The technique presented here attempts to account for this uncertainty by bounding the problem with reasonable cases and using those bounding cases as a statistical sample. Probability of damage curves are computed and represented that account for uncertainty within the sample and enable the war planner to make informed decisions. This work is flexible enough to incorporate any desired damage mechanism and can utilize the variety of finite element and discrete element codes within the national laboratory and government contractor community.

  7. High-Fidelity Measurements of Long-Lived Flux Qubits

    NASA Astrophysics Data System (ADS)

    Hover, David; Macklin, Chris; O'Brien, Kevin; Sears, Adam; Yoder, Jonilyn; Gudmundsen, Ted; Kerman, Jamie; Bolkhovsky, Vladimir; Tolpygo, Sergey; Fitch, George; Weir, Terry; Kamal, Archana; Gustavsson, Simon; Yan, Fei; Birenbaum, Jeff; Siddiqi, Irfan; Orlando, Terry; Clarke, John; Oliver, Will

    2015-03-01

    We report on high-fidelity dispersive measurements of a long-lived flux qubit using a Josephson superconducting traveling wave parametric amplifier (JTWPA). A capacitively shunted flux qubit that incorporates high-Q MBE aluminum will have longer relaxation and dephasing times when compared to a conventional flux qubit, while also maintaining the large anharmonicity necessary for complex gate operations. The JTWPA relies on a Josephson junction embedded transmission line to deliver broadband, nonreciprocal gain with large dynamic range. This research was funded in part by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA); and by the Assistant Secretary of Defense for Research & Engineering under Air Force Contract number FA8721-05-C-0002. All statements of fact, opinion or conclusions contained herein are those of the authors and should not be construed as representing the official views or policies of

  8. Information, entropy and fidelity in visual communication

    NASA Technical Reports Server (NTRS)

    Huck, Friedrich O.; Fales, Carl L.; Alter-Gartenberg, Rachel; Rahman, Zia-Ur

    1992-01-01

    This paper presents an assessment of visual communication that integrates the critical limiting factors of image gathering and display with the digital processing that is used to code and restore images. The approach focuses on two mathematical criteria, information and fidelity, and on their relationships to the entropy of the encoded data and to the visual quality of the restored image.

  9. Fidelity Index Determination of DNA Methyltransferases

    PubMed Central

    Borgaro, Janine G.; Benner, Nicole; Zhu, Zhenyu

    2013-01-01

    DNA methylation is the most frequent form of epigenetic modification in the cell, which involves gene regulation in eukaryotes and protection against restriction enzymes in prokaryotes. Even though many methyltransferases exclusively modify their cognate sites, there have been reports of those that exhibit promiscuity. Previous experimental approaches used to characterize these methyltransferases do not provide the exact concentration at which off-target methylation occurs. Here, we present the first reported fidelity index (FI) for a number of DNA methyltransferases. We define the FI as the ratio of the highest amount of methyltransferase that exhibits no star activity (off-target effects) to the lowest amount that exhibits complete modification of the cognate site. Of the methyltransferases assayed, M.MspI and M.AluI exhibited the highest fidelity of ≥250 and ≥500, respectively, and do not show star activity even at very high concentrations. In contrast, M.HaeIII, M.EcoKDam and M.BamHI have the lowest fidelity of 4, 4 and 2, respectively, and exhibit star activity at concentrations close to complete methylation of the cognate site. The fidelity indexes provide vital information on the usage of methyltransferases and are especially important in applications where site specific methylation is required. PMID:23671703

  10. Examining Model Fidelity via Shadowing Time

    NASA Astrophysics Data System (ADS)

    Du, H.; Smith, L. A.

    2014-12-01

    Fully fledged climate models provide the best available simulations for reflecting the future, yet we have scant insight into their fidelity, in particular as to the duration into the future at which the real world should be expected to evolve in a manner today's models cannot foresee. We know now that our best available models are not adequate for many sought after purposes. To throw some light on the maximum fidelity expected from a given generation of models, and thereby aid both policy making and model development, we can test the weaknesses of a model as a dynamical system to get an informed idea of its potential applicability at various lead times. Shadowing times reflect the duration on which a GCM reflects the observed dynamics of the Earth; extracting the shortcomings of the model which limit shadowing times allows informed speculation regarding the fidelity of the model in the future. More specifically, by identifying the reasons models cannot shadow we learn the relevant phenomena limiting model fidelity, we can then look at the time scales on which feedbacks on the system (which are not active in the model) are likely to result in model irrelevance. The methodology is developed in the "low dimensional laboratory" of relatively simple dynamical systems, for example Lorenz 95 systems. The results are presented in Lorenz 95 systems as well as GCMs. There are severe limits on the light shadowing experiments can shine on GCM predictions. Never the less, they appear to be one of the brightest lights we can shine to illuminate the likely fidelity of GCM extrapolations into the future.

  11. Multi-fidelity modelling for flow over a cylinder

    NASA Astrophysics Data System (ADS)

    Patil, Prerna; Babaee, Hessam; Karniadakis, George

    2016-11-01

    We tackle the classical problem of predicting the relation between CL, CD and CP vs Reynolds number for flow over cylinder using the multi-fidelity framework. The stochastic response surface is obtained by implementing the auto-regressive stochastic modelling (Kennedy and O'Hagan, 2000) and Gaussian process regression to combine data from variable levels of fidelity. In particular, we predict the lift, drag and pressure coefficients where codes with multiple levels of fidelity are available. We correlate data at each of these levels and build the surrogate model using multi-level recursive co-kriging. The deficient physics of the low-fidelity model is explored by examining the cross-correlation between the low-fidelity and high-fidelity models. The proposed framework ultimately intends to meld computational accuracy of the expensive high fidelity with the computational cost of the inexpensive low-fidelity.

  12. Procedural Fidelity: An Analysis of Measurement and Reporting Practices

    ERIC Educational Resources Information Center

    Ledford, Jennifer R.; Wolery, Mark

    2013-01-01

    A systematic analysis was conducted of measurement and reporting practices related to procedural fidelity in single-case research for the past 30 years. Previous reviews of fidelity primarily reported whether fidelity data were collected by authors; these reviews reported that collection was variable, but low across journals and over time. Results…

  13. Teacher Fidelity to One Physical Education Curricular Model

    ERIC Educational Resources Information Center

    Kloeppel, Tiffany; Kulinna, Pamela Hodges; Stylianou, Michalis; van der Mars, Hans

    2013-01-01

    This study addressed teachers' fidelity to one Physical Education curricular model. The theoretical framework guiding this study included professional development and fidelity to curricular models. In this study, teachers' fidelity to the Dynamic Physical Education (DPE) curricular model was measured for high and nonsupport district groups.…

  14. Enhancing Fidelity in Adventure Education and Adventure Therapy

    ERIC Educational Resources Information Center

    Tucker, Anita R.; Rheingold, Alison

    2010-01-01

    Although the importance of addressing and evaluating treatment and program fidelity is clearly emphasized in the literature on psychology, education, and health, little attention has been given to fidelity in adventure literature or research. Program fidelity refers to whether or not, and how well, a specific intervention or program was…

  15. Using a High-Fidelity Patient Simulator with First-Year Medical Students to Facilitate Learning of Cardiovascular Function Curves

    ERIC Educational Resources Information Center

    Harris, David M.; Ryan, Kathleen; Rabuck, Cynthia

    2012-01-01

    Students are relying on technology for learning more than ever, and educators need to adapt to facilitate student learning. High-fidelity patient simulators (HFPS) are usually reserved for the clinical years of medical education and are geared to improve clinical decision skills, teamwork, and patient safety. Finding ways to incorporate HFPS into…

  16. Quantum Fidelity for Arbitrary Gaussian States.

    PubMed

    Banchi, Leonardo; Braunstein, Samuel L; Pirandola, Stefano

    2015-12-31

    We derive a computable analytical formula for the quantum fidelity between two arbitrary multimode Gaussian states which is simply expressed in terms of their first- and second-order statistical moments. We also show how such a formula can be written in terms of symplectic invariants and used to derive closed forms for a variety of basic quantities and tools, such as the Bures metric, the quantum Fisher information, and various fidelity-based bounds. Our result can be used to extend the study of continuous-variable protocols, such as quantum teleportation and cloning, beyond the current one-mode or two-mode analyses, and paves the way to solve general problems in quantum metrology and quantum hypothesis testing with arbitrary multimode Gaussian resources.

  17. Competitive environments induce shifts in host fidelity.

    PubMed

    Rova, E; Björklund, M

    2010-08-01

    Recent models support the idea of sympatric speciation as a result of the joint effects of disruptive selection and assortative mating. We present experimental data, testing models of speciation through frequency-dependent selection. We show that under high competition on a mixture of resources/hosts, strains of the Seed beetle, Callosobruchus maculatus, change their host fidelity and evolve a more generalistic behaviour in resource utilization among females. The change in host fidelity did not result in disruptive selection and was not followed by assortative mating. This means that only one of three fundamental prerequisites for sympatric speciation evolved as a result of the frequency-dependent selection. We conclude that for this process to work, a shift to a novel food resource as a result of selection must also lead to a loss of preference for the original resource such that individuals are only able to use either one of the two.

  18. Quantum Fidelity for Arbitrary Gaussian States

    NASA Astrophysics Data System (ADS)

    Banchi, Leonardo; Braunstein, Samuel L.; Pirandola, Stefano

    2015-12-01

    We derive a computable analytical formula for the quantum fidelity between two arbitrary multimode Gaussian states which is simply expressed in terms of their first- and second-order statistical moments. We also show how such a formula can be written in terms of symplectic invariants and used to derive closed forms for a variety of basic quantities and tools, such as the Bures metric, the quantum Fisher information, and various fidelity-based bounds. Our result can be used to extend the study of continuous-variable protocols, such as quantum teleportation and cloning, beyond the current one-mode or two-mode analyses, and paves the way to solve general problems in quantum metrology and quantum hypothesis testing with arbitrary multimode Gaussian resources.

  19. The architecture of RNA polymerase fidelity.

    PubMed

    Kaplan, Craig D

    2010-06-22

    The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates. See research article http://www.biomedcentral.com/1741-7007/8/54.

  20. Perceptual Fidelity for Digital Color Imagery

    DTIC Science & Technology

    1996-12-01

    AFIT/DS/ENG/96-14 PERCEPTUAL FIDELITY FOR DIGITAL COLOR IMAGERY DISSERTATION Curtis Eli Martin Captain, USAF AFIT/DS/ENG/96-14 Approved for public...SIGNIFICANT NUMBER OF COLOR PAGES WHICH DO NOT REPRODUCE LEGIBLY ON BLACK AND WHITE MICROFICHE. The views expressed in this dissertation are those of the...FOR DIGITAL COLOR IMAGERY DISSERTATION Presented to the Faculty of the Graduate School of Engineering of the Air Force Institute of Technology Air

  1. Gravity Modeling for Variable Fidelity Environments

    NASA Technical Reports Server (NTRS)

    Madden, Michael M.

    2006-01-01

    Aerospace simulations can model worlds, such as the Earth, with differing levels of fidelity. The simulation may represent the world as a plane, a sphere, an ellipsoid, or a high-order closed surface. The world may or may not rotate. The user may select lower fidelity models based on computational limits, a need for simplified analysis, or comparison to other data. However, the user will also wish to retain a close semblance of behavior to the real world. The effects of gravity on objects are an important component of modeling real-world behavior. Engineers generally equate the term gravity with the observed free-fall acceleration. However, free-fall acceleration is not equal to all observers. To observers on the sur-face of a rotating world, free-fall acceleration is the sum of gravitational attraction and the centrifugal acceleration due to the world's rotation. On the other hand, free-fall acceleration equals gravitational attraction to an observer in inertial space. Surface-observed simulations (e.g. aircraft), which use non-rotating world models, may choose to model observed free fall acceleration as the gravity term; such a model actually combines gravitational at-traction with centrifugal acceleration due to the Earth s rotation. However, this modeling choice invites confusion as one evolves the simulation to higher fidelity world models or adds inertial observers. Care must be taken to model gravity in concert with the world model to avoid denigrating the fidelity of modeling observed free fall. The paper will go into greater depth on gravity modeling and the physical disparities and synergies that arise when coupling specific gravity models with world models.

  2. Fidelity Optimization of Microprocessor System Simulations.

    DTIC Science & Technology

    1981-03-01

    I. TIT LE (end Su.btitle) 5 TYPE OF REPORT A PERIOD COVERED " Fidelity Optimization of Microprocessor THESIS /DgW&YON/ System Simulations...MICROPROCESSOR SYSTEM SIHULATIONS Earnest Taylor Landrum, Jr. A Thesis Submitted to the Graduate Faculty of Auburn University in Partial Fulfillment of the...Taylor Landrum, Jr. Permission is herewith granted to Auburn University to make copies of this thesis at its discretion, upon the request of

  3. Bandwidth and SIMDUCE as simulator fidelity criteria

    NASA Technical Reports Server (NTRS)

    Key, David

    1992-01-01

    The potential application of two concepts from the new Handling Qualities Specification for Military Rotorcraft was discussed. The first concept is bandwidth, a measure of the dynamic response to control. The second is a qualitative technique developed for assessing the visual cue environment the pilot has in bad weather and at night. Simulated Day Usable Cue Environment (SIMDUCE) applies this concept to assessing the day cuing fidelity in the simulator.

  4. Mismatch repair balances leading and lagging strand DNA replication fidelity.

    PubMed

    Lujan, Scott A; Williams, Jessica S; Pursell, Zachary F; Abdulovic-Cui, Amy A; Clark, Alan B; Nick McElhinny, Stephanie A; Kunkel, Thomas A

    2012-01-01

    The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform lagging strand replication. The fact that these polymerases differ in fidelity and error specificity is interesting in light of the fact that the stability of the nuclear genome depends in part on the ability of mismatch repair (MMR) to correct different mismatches generated in different contexts during replication. Here we provide the first comparison, to our knowledge, of the efficiency of MMR of leading and lagging strand replication errors. We first use the strand-biased ribonucleotide incorporation propensity of a Pol ε mutator variant to confirm that Pol ε is the primary leading strand replicase in Saccharomyces cerevisiae. We then use polymerase-specific error signatures to show that MMR efficiency in vivo strongly depends on the polymerase, the mismatch composition, and the location of the mismatch. An extreme case of variation by location is a T-T mismatch that is refractory to MMR. This mismatch is flanked by an AT-rich triplet repeat sequence that, when interrupted, restores MMR to > 95% efficiency. Thus this natural DNA sequence suppresses MMR, placing a nearby base pair at high risk of mutation due to leading strand replication infidelity. We find that, overall, MMR most efficiently corrects the most potentially deleterious errors (indels) and then the most common substitution mismatches. In combination with earlier studies, the results suggest that significant differences exist in the generation and repair of Pol α, δ, and ε replication errors, but in a generally complementary manner that results in high-fidelity replication of both DNA strands of the yeast nuclear genome.

  5. Framework for Multidisciplinary Analysis, Design, and Optimization with High-Fidelity Analysis Tools

    NASA Technical Reports Server (NTRS)

    Orr, Stanley A.; Narducci, Robert P.

    2009-01-01

    A plan is presented for the development of a high fidelity multidisciplinary optimization process for rotorcraft. The plan formulates individual disciplinary design problems, identifies practical high-fidelity tools and processes that can be incorporated in an automated optimization environment, and establishes statements of the multidisciplinary design problem including objectives, constraints, design variables, and cross-disciplinary dependencies. Five key disciplinary areas are selected in the development plan. These are rotor aerodynamics, rotor structures and dynamics, fuselage aerodynamics, fuselage structures, and propulsion / drive system. Flying qualities and noise are included as ancillary areas. Consistency across engineering disciplines is maintained with a central geometry engine that supports all multidisciplinary analysis. The multidisciplinary optimization process targets the preliminary design cycle where gross elements of the helicopter have been defined. These might include number of rotors and rotor configuration (tandem, coaxial, etc.). It is at this stage that sufficient configuration information is defined to perform high-fidelity analysis. At the same time there is enough design freedom to influence a design. The rotorcraft multidisciplinary optimization tool is built and substantiated throughout its development cycle in a staged approach by incorporating disciplines sequentially.

  6. High-Fidelity Roadway Modeling and Simulation

    NASA Technical Reports Server (NTRS)

    Wang, Jie; Papelis, Yiannis; Shen, Yuzhong; Unal, Ozhan; Cetin, Mecit

    2010-01-01

    Roads are an essential feature in our daily lives. With the advances in computing technologies, 2D and 3D road models are employed in many applications, such as computer games and virtual environments. Traditional road models were generated by professional artists manually using modeling software tools such as Maya and 3ds Max. This approach requires both highly specialized and sophisticated skills and massive manual labor. Automatic road generation based on procedural modeling can create road models using specially designed computer algorithms or procedures, reducing the tedious manual editing needed for road modeling dramatically. But most existing procedural modeling methods for road generation put emphasis on the visual effects of the generated roads, not the geometrical and architectural fidelity. This limitation seriously restricts the applicability of the generated road models. To address this problem, this paper proposes a high-fidelity roadway generation method that takes into account road design principles practiced by civil engineering professionals, and as a result, the generated roads can support not only general applications such as games and simulations in which roads are used as 3D assets, but also demanding civil engineering applications, which requires accurate geometrical models of roads. The inputs to the proposed method include road specifications, civil engineering road design rules, terrain information, and surrounding environment. Then the proposed method generates in real time 3D roads that have both high visual and geometrical fidelities. This paper discusses in details the procedures that convert 2D roads specified in shape files into 3D roads and civil engineering road design principles. The proposed method can be used in many applications that have stringent requirements on high precision 3D models, such as driving simulations and road design prototyping. Preliminary results demonstrate the effectiveness of the proposed method.

  7. A multievent approach to estimating pair fidelity and heterogeneity in state transitions

    PubMed Central

    Culina, Antica; Lachish, Shelly; Pradel, Roger; Choquet, Remi; Sheldon, Ben C

    2013-01-01

    Fidelity rates of pair-bonded individuals are of considerable interest to behavioral and population biologists as they can influence population structure, mating rates, population productivity, and gene flow. Estimates of fidelity rates calculated from direct observations of pairs in consecutive breeding seasons may be biased because (i) individuals that are not seen are assumed to be dead, (ii) variation in the detectability of individuals is ignored, and (iii) pair status must be known with certainty. This can lead to a high proportion of observations being ignored. This approach also restricts the way variation in fidelity rates for different types of individuals, or the covariation between fidelity and other vital rates (e.g., survival) can be analyzed. In this study, we develop a probabilistic multievent capture–mark–recapture (MECMR) modeling framework for estimating pair fidelity rates that accounts for imperfect detection rates and capture heterogeneity, explicitly incorporates uncertainty in the assessment of pair status, and allows estimates of state-dependent survival and fidelity rates to be obtained simultaneously. We demonstrate the utility of our approach for investigating patterns of fidelity in pair-bonded individuals, by applying it to 30 years of breeding data from a wild population of great tits Parus major Linnaeus. Results of model selection supported state-dependent recapture, survival, and fidelity rates. Recapture rates were higher for individuals breeding with their previous partner than for those breeding with a different partner. Faithful birds that were breeding with the same partner as in the previous breeding season (i.e., at t − 1) experienced substantially higher survival rates (between t and t + 1) and were also more likely to remain faithful to their current partner (i.e., to remain in the faithful state at t + 1). First year breeders were more likely to change partner than older birds. These findings imply that traditional

  8. Polarization fidelity in an optical interferometer

    NASA Astrophysics Data System (ADS)

    Buscher, David F.; Baron, Fabien; Haniff, Christopher A.

    2008-07-01

    The optical trains of interferometers invariably contain oblique reflections that alter the polarization state of the light from the source. Even for arrays with symmetric optical paths, large systematic visibility errors can be introduced when observing sources with intrinsic polarization. We have identified the key metric for polarization fidelity in an optical interferometer - the diattenuation of the optical train - and we evaluate the visibility penalties incurred by an interferometer that is not optimized for polarimetric purity for a number of different types of polarized source.

  9. Fidelity of adiabatic holonomic quantum gates

    NASA Astrophysics Data System (ADS)

    Malinovsky, Vladimir; Rudin, Sergey

    2016-05-01

    During last few years non-Abelian geometric phases are attracting increasing interest due to possible experimental applications in quantum computation. Here we discuss universal set of holonomic quantum gates using the geometric phase that the qubit wave function acquires after a cyclic evolution. The proposed scheme utilizes ultrafast pulses and provides a possibility to substantially suppress transient population of the ancillary states. Fidelity of the holonomic quantum gates in the presence of dephasing and dissipation is discussed. Example of electron spin qubit system in the InGaN/GaN, GaN/AlN quantum dot is considered in details.

  10. Transportable setup for amplifier phase fidelity measurements

    NASA Astrophysics Data System (ADS)

    Tröbs, M.; Bogan, C.; Barke, S.; Kühn, G.; Reiche, J.; Heinzel, G.; Danzmann, K.

    2015-05-01

    One possible laser source for the Laser Interferometer Space Antenna (LISA) consists of an Ytterbium-doped fiber amplifier originally developed for inter-satellite communication, seeded by the laser used for the technology demonstrator mission LISA Pathfinder. LISA needs to transmit clock information between its three spacecraft to correct for phase noise between the clocks on the individual spacecraft. For this purpose phase modulation sidebands at GHz frequencies will be imprinted on the laser beams between spacecraft. Differential phase noise between the carrier and a sideband introduced within the optical chain must be very low. We report on a transportable setup to measure the phase fidelity of optical amplifiers.

  11. Toward fidelity between specification and implementation

    NASA Technical Reports Server (NTRS)

    Callahan, John R.; Montgomery, Todd L.; Morrison, Jeff; Wu, Yunqing

    1994-01-01

    This paper describes the methods used to specify and implement a complex communications protocol that provides reliable delivery of data in multicast-capable, packet-switching telecommunication networks. The protocol, called the Reliable Multicasting Protocol (RMP), was developed incrementally by two complementary teams using a combination of formal and informal techniques in an attempt to ensure the correctness of the protocol implementation. The first team, called the Design team, initially specified protocol requirements using a variant of SCR requirements tables and implemented a prototype solution. The second team, called the V&V team, developed a state model based on the requirements tables and derived test cases from these tables to exercise the implementation. In a series of iterative steps, the Design team added new functionality to the implementation while the V&V team kept the state model in fidelity with the implementation through testing. Test cases derived from state transition paths in the formal model formed the dialogue between teams during development and served as the vehicles for keeping the model and implementation in fidelity with each other. This paper describes our experiences in developing our process model, details of our approach, and some example problems found during the development of RMP.

  12. How Fidelity invests in service professionals.

    PubMed

    McColgan, E A

    1997-01-01

    If you're in the business of service delivery, investment in the training and development of your staff is one of the keys to your company's success. But what's the best way to design and implement your investment? In 1994, Fidelity Institutional Retirement Services Company (FIRSCo) needed to ensure that its rapidly expanding staff maintained the company's high levels of customer satisfaction. The solution, according to Ellyn McColgan, formerly an executive vice president of FIRSCo and now the president of Fidelity Investments Tax-Exempt Services Company, was to reach out to its service associates with a powerful new model for training and development called Service Delivery University. SDU is a virtual university with a content-based core curriculum and five colleges that focus on business concepts and skills. It is driven by three principles. First, all training must be directly aligned with the company's strategic and financial objectives and focused on customer needs. Second, service delivery is a profession and should be taught as such. And finally, professional development should be the primary responsibility of line managers rather than the human resources department. McColgan explains how FIRSCo overcame resistance to this sweeping change in employee education. (Time was one obstacle: each associate receives 80 hours of training per year.) In addition, the author discusses the fine art of measuring the success of a program like SDU. She finds that the company's investment has paid dividends to the staff, to the organization as a whole, and to FIRSCo's customers.

  13. High-Fidelity Flash Lidar Model Development

    NASA Technical Reports Server (NTRS)

    Hines, Glenn D.; Pierrottet, Diego F.; Amzajerdian, Farzin

    2014-01-01

    NASA's Autonomous Landing and Hazard Avoidance Technologies (ALHAT) project is currently developing the critical technologies to safely and precisely navigate and land crew, cargo and robotic spacecraft vehicles on and around planetary bodies. One key element of this project is a high-fidelity Flash Lidar sensor that can generate three-dimensional (3-D) images of the planetary surface. These images are processed with hazard detection and avoidance and hazard relative navigation algorithms, and then are subsequently used by the Guidance, Navigation and Control subsystem to generate an optimal navigation solution. A complex, high-fidelity model of the Flash Lidar was developed in order to evaluate the performance of the sensor and its interaction with the interfacing ALHAT components on vehicles with different configurations and under different flight trajectories. The model contains a parameterized, general approach to Flash Lidar detection and reflects physical attributes such as range and electronic noise sources, and laser pulse temporal and spatial profiles. It also provides the realistic interaction of the laser pulse with terrain features that include varying albedo, boulders, craters slopes and shadows. This paper gives a description of the Flash Lidar model and presents results from the Lidar operating under different scenarios.

  14. Toward the Effective and Efficient Measurement of Implementation Fidelity

    PubMed Central

    Schoenwald, Sonja K.; Garland, Ann F.; Chapman, Jason E.; Frazier, Stacy L.; Sheidow, Ashli J.; Southam-Gerow, Michael A.

    2011-01-01

    Implementation science in mental health is informed by other academic disciplines and industries. Conceptual and methodological territory charted in psychotherapy research is pertinent to two elements of the conceptual model of implementation posited by Aarons and colleagues (2010)—implementation fidelity and innovation feedback systems. Key characteristics of scientifically validated fidelity instruments, and of the feasibility of their use in routine care, are presented. The challenges of ensuring fidelity measurement methods are both effective (scientifically validated) and efficient (feasible and useful in routine care) are identified as are examples of implementation research attempting to balance these attributes of fidelity measurement. PMID:20957425

  15. Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases.

    PubMed

    Yang, Xiaorong; Liu, Xinran; Musser, Derek M; Moustafa, Ibrahim M; Arnold, Jamie J; Cameron, Craig E; Boehr, David D

    2017-03-03

    The nucleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for maintaining functional genetic information but, at the same time, is also important for generating sufficient genetic diversity to escape the bottlenecks of the host's antiviral response. We have previously shown that the structural dynamics of the motif D loop are closely related to nucleotide discrimination. Previous studies have also suggested that there is a reorientation of the triphosphate of the incoming nucleotide, which is essential before nucleophilic attack from the primer RNA 3'-hydroxyl. Here, we have used (31)P NMR with poliovirus RdRp to show that the binding environment of the triphosphate is different when correct versus incorrect nucleotide binds. We also show that amino acid substitutions at residues known to interact with the triphosphate can alter the binding orientation/environment of the nucleotide, sometimes lead to protein conformational changes, and lead to substantial changes in RdRp fidelity. The analyses of other fidelity variants also show that changes in the triphosphate binding environment are not always accompanied by changes in the structural dynamics of the motif D loop or other regions known to be important for RdRp fidelity, including motif B. Altogether, our studies suggest that the conformational changes in motifs B and D, and the nucleoside triphosphate reorientation represent separable, "tunable" fidelity checkpoints.

  16. High-Fidelity Micromechanics Model Enhanced for Multiphase Particulate Materials

    NASA Technical Reports Server (NTRS)

    Pindera, Marek-Jerzy; Arnold, Steven M.

    2003-01-01

    This 3-year effort involves the development of a comprehensive micromechanics model and a related computer code, capable of accurately estimating both the average response and the local stress and strain fields in the individual phases, assuming both elastic and inelastic behavior. During the first year (fiscal year 2001) of the investigation, a version of the model called the High-Fidelity Generalized Method of Cells (HFGMC) was successfully completed for the thermo-inelastic response of continuously reinforced multiphased materials with arbitrary periodic microstructures (refs. 1 and 2). The model s excellent predictive capability for both the macroscopic response and the microlevel stress and strain fields was demonstrated through comparison with exact analytical and finite element solutions. This year, HFGMC was further extended in two technologically significant ways. The first enhancement entailed the incorporation of fiber/matrix debonding capability into the two-dimensional version of HFGMC for modeling the response of unidirectionally reinforced composites such as titanium matrix composites, which exhibit poor fiber/matrix bond. Comparison with experimental data validated the model s predictive capability. The second enhancement entailed further generalization of HFGMC to three dimensions to enable modeling the response of particulate-reinforced (discontinuous) composites in the elastic material behavior domain. Next year, the three-dimensional version will be generalized to encompass inelastic effects due to plasticity, viscoplasticity, and damage, as well as coupled electromagnetothermomechanical (including piezoelectric) effects.

  17. Fluctuation and fidelity control of a non-proofreading polymerase

    NASA Astrophysics Data System (ADS)

    Yu, Jin

    2014-03-01

    Polymerases catalyze gene replication and transcription. They modulate activation barriers of nucleotide incorporation and amplify maximal free energy differentiation between the right and wrong nucleotides. It is essential for the polymerases to achieve sufficiently high fidelity at sufficiently high speed. We had noticed a small free energy bias in the translocation of T7 RNA polymerase (RNAP) that aids nucleotide selection. We investigated further how polymerases select against wrong nucleotides efficiently with given kinetics for the right, and with controlled differentiation capacities. We found that early selections on the reaction path outperform the late ones in error reduction. In particular, initial screening seems indispensable for lowering error rates without lowering much the speed. To see how exactly the nucleotide selection proceeds, we studied T7 RNAP also in atomistic simulations. We found that substantial nucleotide selection happens early, prior to full insertion of the nucleotide for complete Watson-Crick base pairing. A highly conserved residue brings up the small translocation energy bias by marginally blocking the active site. The residue senses the nucleotide species upon the nucleotide pre-insertion, and selectively `gates' the nucleotide during insertion. Our studies thus provide a kinetic survey of the nucleotide selection system along with underlying molecular mechanisms.

  18. Medium Fidelity Simulation of Oxygen Tank Venting

    NASA Technical Reports Server (NTRS)

    Sweet, Adam; Kurien, James; Lau, Sonie (Technical Monitor)

    2001-01-01

    The item to he cleared is a medium-fidelity software simulation model of a vented cryogenic tank. Such tanks are commonly used to transport cryogenic liquids such as liquid oxygen via truck, and have appeared on liquid-fueled rockets for decades. This simulation model works with the HCC simulation system that was developed by Xerox PARC and NASA Ames Research Center. HCC has been previously cleared for distribution. When used with the HCC software, the model generates simulated readings for the tank pressure and temperature as the simulated cryogenic liquid boils off and is vented. Failures (such as a broken vent valve) can be injected into the simulation to produce readings corresponding to the failure. Release of this simulation will allow researchers to test their software diagnosis systems by attempting to diagnose the simulated failure from the simulated readings. This model does not contain any encryption software nor can it perform any control tasks that might be export controlled.

  19. Visual communication - Information and fidelity. [of images

    NASA Technical Reports Server (NTRS)

    Huck, Freidrich O.; Fales, Carl L.; Alter-Gartenberg, Rachel; Rahman, Zia-Ur; Reichenbach, Stephen E.

    1993-01-01

    This assessment of visual communication deals with image gathering, coding, and restoration as a whole rather than as separate and independent tasks. The approach focuses on two mathematical criteria, information and fidelity, and on their relationships to the entropy of the encoded data and to the visual quality of the restored image. Past applications of these criteria to the assessment of image coding and restoration have been limited to the link that connects the output of the image-gathering device to the input of the image-display device. By contrast, the approach presented in this paper explicitly includes the critical limiting factors that constrain image gathering and display. This extension leads to an end-to-end assessment theory of visual communication that combines optical design with digital processing.

  20. Picornaviral polymerase structure, function, and fidelity modulation.

    PubMed

    Peersen, Olve B

    2017-02-02

    Like all positive strand RNA viruses, the picornaviruses replicate their genomes using a virally encoded RNA-dependent RNA polymerase enzyme known as 3D(pol). Over the past decade we have made tremendous advances in our understanding of 3D(pol) structure and function, including the discovery of a novel mechanism for closing the active site that allows these viruses to easily fine tune replication fidelity and quasispecies distributions. This review summarizes current knowledge of picornaviral polymerase structure and how the enzyme interacts with RNA and other viral proteins to form stable and processive elongation complexes. The picornaviral RdRPs are among the smallest viral polymerases, but their fundamental molecular mechanism for catalysis appears to be generally applicable as a common feature of all positive strand RNA virus polymerases.

  1. Commentary: Learning from Variations in Fidelity of Implementation

    ERIC Educational Resources Information Center

    Balu, Rekha; Doolittle, Fred

    2016-01-01

    The articles in this special issue discuss efforts to improve academic reading outcomes for students and ways to achieve high implementation fidelity of promising strategies. At times the authors discuss if--and how--strong fidelity is associated with strong outcomes and potentially even impacts (the difference between program and control group…

  2. Assessing Fidelity of Implementation of an Unprescribed, Diagnostic Mathematics Intervention

    ERIC Educational Resources Information Center

    Munter, Charles; Wilhelm, Anne Garrison; Cobb, Paul; Cordray, David S.

    2014-01-01

    This article draws on previously employed methods for conducting fidelity studies and applies them to an evaluation of an unprescribed intervention. We document the process of assessing the fidelity of implementation of the Math Recovery first-grade tutoring program, an unprescribed, diagnostic intervention. We describe how we drew on recent…

  3. A Narrative Review of Generic Intervention Fidelity Measures

    ERIC Educational Resources Information Center

    Di Rezze, Briano; Law, Mary; Gorter, Jan Willem; Eva, Kevin; Pollock, Nancy

    2012-01-01

    To increase the rigor of pediatric rehabilitation research, there is a need to evaluate the degree to which an intervention is conducted as planned (i.e., fidelity). Generic fidelity measures evaluate more than one intervention and often include nonspecific attributes of the therapy process common to both interventions. The objective of this study…

  4. Intervention Fidelity in Special and General Education Research Journals

    ERIC Educational Resources Information Center

    Swanson, Elizabeth; Wanzek, Jeanne; Haring, Christa; Ciullo, Stephen; McCulley, Lisa

    2013-01-01

    Treatment fidelity reporting practices are described for journals that published general and special education intervention research with high impact factors from 2005 through 2009. The authors reviewed research articles, reported the proportion of intervention studies that described fidelity measurement, detailed the components of fidelity…

  5. High Fidelity Simulation of Atomization in Diesel Engine Sprays

    DTIC Science & Technology

    2015-09-01

    structure of the high speed jet. The turbulent Atomization in diesel engine sprays 9 !"# $ $"# % %"# &’$! ï...ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L Bravo...ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L

  6. Multifractality in fidelity sequences of optimized Toffoli gates

    NASA Astrophysics Data System (ADS)

    Moqadam, Jalil Khatibi; Welter, Guilherme S.; Esquef, Paulo A. A.

    2016-11-01

    We analyze the multifractality in the fidelity sequences of several engineered Toffoli gates. Using quantum control methods, we consider several optimization problems whose global solutions realize the gate in a chain of three qubits with XY Heisenberg interaction. Applying a minimum number of control pulses assuring a fidelity above 99 % in the ideal case, we design stable gates that are less sensitive to variations in the interqubits couplings. The most stable gate has the fidelity above 91 % with variations about 0.1 %, for up to 10 % variation in the nominal couplings. We perturb the system by introducing a single source of 1 / f noise that affects all the couplings. In order to quantify the performance of the proposed optimized gates, we calculate the fidelity of a large set of optimized gates under prescribed levels of coupling perturbation. Then, we run multifractal analysis on the sequence of attained fidelities. This way, gate performance can be assessed beyond mere average results, since the chosen multifractality measure (the width of the multifractal spectrum) encapsulates into a single performance indicator the spread of fidelity values around the mean and the presence of outliers. The higher the value of the performance indicator the more concentrated around the mean the fidelity values are and rarer is the occurrence of outliers. The results of the multifractal analysis on the fidelity sequences demonstrate the effectiveness of the proposed optimized gate implementations, in the sense they are rendered less sensitive to variations in the interqubits coupling strengths.

  7. Challenges of applying a comprehensive model of intervention fidelity.

    PubMed

    Bosak, Kelly A; Pozehl, Bunny; Yates, Bernice

    2012-06-01

    Applying a comprehensive model of fidelity to interventions delivered by information and communication technologies (ICTs) has multiple challenges. Fidelity must be considered in the design, implementation, evaluation, and reporting of the intervention. The fidelity strategies must address the unique aspects of the technology, including training providers to instruct participants to use the technology and provide standardized feedback, rather than delivering the intervention in person. Other challenges include the nonspecific effects resulting from participants accessing unintended content in interventions using the Internet. ICT allows participant receipt and enactment of intervention skills to be assessed by electronic evidence, rather than in-person observation. Interventions delivered by ICT are unique, and there is less control of participant interaction with various electronic components. Monitoring participant use and providing standardized feedback for receipt and enactment of intervention skills are key to ensuring fidelity. The final challenges involve evaluating and reporting fidelity of the intervention.

  8. A narrative review of generic intervention fidelity measures.

    PubMed

    Di Rezze, Briano; Law, Mary; Gorter, Jan Willem; Eva, Kevin; Pollock, Nancy

    2012-11-01

    To increase the rigor of pediatric rehabilitation research, there is a need to evaluate the degree to which an intervention is conducted as planned (i.e., fidelity). Generic fidelity measures evaluate more than one intervention and often include nonspecific attributes of the therapy process common to both interventions. The objective of this study was to describe the characteristics of generic fidelity measures and examine how these attributes fit with pediatric rehabilitation. A review of generic fidelity measures was conducted utilizing health and education databases. Five generic fidelity measures are described and examined for their applicability to pediatric rehabilitation. The measures were used in nine studies meeting the inclusion criteria, involving people ages from 11 years to >65 years undergoing psychotherapy. From the 76 nonspecific items, 37 items were judged to be applicable to pediatric rehabilitation. Common characteristics of nonspecific attributes with pediatric rehabilitation are discussed, and investigator plans to conduct future testing.

  9. Objective Fidelity Evaluation in Multisensory Virtual Environments: Auditory Cue Fidelity in Flight Simulation

    PubMed Central

    Meyer, Georg F.; Wong, Li Ting; Timson, Emma; Perfect, Philip; White, Mark D.

    2012-01-01

    We argue that objective fidelity evaluation of virtual environments, such as flight simulation, should be human-performance-centred and task-specific rather than measure the match between simulation and physical reality. We show how principled experimental paradigms and behavioural models to quantify human performance in simulated environments that have emerged from research in multisensory perception provide a framework for the objective evaluation of the contribution of individual cues to human performance measures of fidelity. We present three examples in a flight simulation environment as a case study: Experiment 1: Detection and categorisation of auditory and kinematic motion cues; Experiment 2: Performance evaluation in a target-tracking task; Experiment 3: Transferrable learning of auditory motion cues. We show how the contribution of individual cues to human performance can be robustly evaluated for each task and that the contribution is highly task dependent. The same auditory cues that can be discriminated and are optimally integrated in experiment 1, do not contribute to target-tracking performance in an in-flight refuelling simulation without training, experiment 2. In experiment 3, however, we demonstrate that the auditory cue leads to significant, transferrable, performance improvements with training. We conclude that objective fidelity evaluation requires a task-specific analysis of the contribution of individual cues. PMID:22957068

  10. The effectiveness of the use of high fidelity simulators in obstetric ultrasound training: A systematic review

    PubMed Central

    Parange, Nayana; Thoirs, Kerry

    2015-01-01

    Abstract Introduction: The benefits of the use of ultrasound technology for point of care obstetric health evaluation have led to increased focus on training programs for physicians wanting to develop skills in this area. Simulation, in a variety of formats, has always played a role in medical and health training, with proven benefits. This systematic review determines the level of evidence available to support the use of high fidelity ultrasound simulators in the training of obstetric ultrasound scanning skills to health professionals. Methods: A systematic review of the literature was performed to define previous investigations into the incorporation of high fidelity ultrasound simulators into obstetric ultrasound training programs. The included studies were reviewed by the authors to evaluate their overall strength and quality. Data surrounding the study participants, simulator types, study design, training program format, outcome measures, and results were extracted. Results and conclusions: While the small body of evidence discovered in this review demonstrates positive results for the use of high fidelity simulators in obstetric ultrasound training, the studies included in this review demonstrate a moderate level of evidence, with some potential of bias throughout. A number of gaps in the literature were identified that could be addressed in further research. PMID:28191251

  11. Sustaining Fidelity Following the Nationwide PMTO™ Implementation in Norway

    PubMed Central

    Forgatch, Marion S.; DeGarmo, David S.

    2011-01-01

    This report describes three studies from the nationwide Norwegian implementation of Parent Management Training – Oregon Model (PMTO™), an empirically supported treatment for families of children with behavior problems (Forgatch and Patterson 2010). Separate stages of the implementation were evaluated using a fidelity measure based on direct observation of intervention sessions. Study 1 assessed growth in fidelity observed early, mid, and late in the training of a group of practitioners. We hypothesized increased fidelity and decreased variability in practice. Study 2 evaluated method fidelity over the course of three generations of practitioners trained in PMTO. Generation 1 (G1) was trained by the PMTO developer/purveyors; Generation 2 (G2) was trained by selected G1 Norwegian trainers; and Generation 3 (G3) was trained by G1 and G2 trainers. We hypothesized decrease in fidelity with each generation. Study 3 tested the predictive validity of fidelity in a cross-cultural replication, hypothesizing that higher fidelity scores would correlate with improved parenting practices observed in parent-child interactions before and after treatment. In Study 1, trainees' performance improved and became more homogeneous as predicted. In Study 2, a small decline in fidelity followed the transfer from the purveyor trainers to Norwegian trainers in G2, but G3 scores were equivalent to those attained by G1. Thus, the hypothesis was not fully supported. Finally, the FIMP validity model replicated; PMTO fidelity significantly contributed to improvements in parenting practices from pre- to post-treatment. The data indicate that PMTO was transferred successfully to Norwegian implementation with sustained fidelity and cross-cultural generalization. PMID:21671090

  12. High-Fidelity Micromechanics Model Developed for the Response of Multiphase Materials

    NASA Technical Reports Server (NTRS)

    Aboudi, Jacob; Pindera, Marek-Jerzy; Arnold, Steven M.

    2002-01-01

    A new high-fidelity micromechanics model has been developed under funding from the NASA Glenn Research Center for predicting the response of multiphase materials with arbitrary periodic microstructures. The model's analytical framework is based on the homogenization technique, but the method of solution for the local displacement and stress fields borrows concepts previously employed in constructing the higher order theory for functionally graded materials. The resulting closed-form macroscopic and microscopic constitutive equations, valid for both uniaxial and multiaxial loading of periodic materials with elastic and inelastic constitutive phases, can be incorporated into a structural analysis computer code. Consequently, this model now provides an alternative, accurate method.

  13. Quantum state tomography and fidelity estimation via Phaselift

    SciTech Connect

    Lu, Yiping; Liu, Huan; Zhao, Qing

    2015-09-15

    Experiments of multi-photon entanglement have been performed by several groups. Obviously, an increase on the photon number for fidelity estimation and quantum state tomography causes a dramatic increase in the elements of the positive operator valued measures (POVMs), which results in a great consumption of time in measurements. In practice, we wish to obtain a good estimation of fidelity and quantum states through as few measurements as possible for multi-photon entanglement. Phaselift provides such a chance to estimate fidelity for entangling states based on less data. In this paper, we would like to show how the Phaselift works for six qubits in comparison to the data given by Pan’s group, i.e., we use a fraction of the data as input to estimate the rest of the data through the obtained density matrix, and thus goes beyond the simple fidelity analysis. The fidelity bound is also provided for general Schrödinger Cat state. Based on the fidelity bound, we propose an optimal measurement approach which could both reduce the copies and keep the fidelity bound gap small. The results demonstrate that the Phaselift can help decrease the measured elements of POVMs for six qubits. Our conclusion is based on the prior knowledge that a pure state is the target state prepared by experiments.

  14. Status report on high fidelity reactor simulation.

    SciTech Connect

    Palmiotti, G.; Smith, M.; Rabiti, C.; Lewis, E.; Yang, W.; Leclere,M.; Siegel, A.; Fischer, P.; Kaushik, D.; Ragusa, J.; Lottes, J.; Smith, B.

    2006-12-11

    This report presents the effort under way at Argonne National Laboratory toward a comprehensive, integrated computational tool intended mainly for the high-fidelity simulation of sodium-cooled fast reactors. The main activities carried out involved neutronics, thermal hydraulics, coupling strategies, software architecture, and high-performance computing. A new neutronics code, UNIC, is being developed. The first phase involves the application of a spherical harmonics method to a general, unstructured three-dimensional mesh. The method also has been interfaced with a method of characteristics. The spherical harmonics equations were implemented in a stand-alone code that was then used to solve several benchmark problems. For thermal hydraulics, a computational fluid dynamics code called Nek5000, developed in the Mathematics and Computer Science Division for coupled hydrodynamics and heat transfer, has been applied to a single-pin, periodic cell in the wire-wrap geometry typical of advanced burner reactors. Numerical strategies for multiphysics coupling have been considered and higher-accuracy efficient methods proposed to finely simulate coupled neutronic/thermal-hydraulic reactor transients. Initial steps have been taken in order to couple UNIC and Nek5000, and simplified problems have been defined and solved for testing. Furthermore, we have begun developing a lightweight computational framework, based in part on carefully selected open source tools, to nonobtrusively and efficiently integrate the individual physics modules into a unified simulation tool.

  15. Fidelity of the Integrated Force Method Solution

    NASA Technical Reports Server (NTRS)

    Hopkins, Dale; Halford, Gary; Coroneos, Rula; Patnaik, Surya

    2002-01-01

    The theory of strain compatibility of the solid mechanics discipline was incomplete since St. Venant's 'strain formulation' in 1876. We have addressed the compatibility condition both in the continuum and the discrete system. This has lead to the formulation of the Integrated Force Method. A dual Integrated Force Method with displacement as the primal variable has also been formulated. A modest finite element code (IFM/Analyzers) based on the IFM theory has been developed. For a set of standard test problems the IFM results were compared with the stiffness method solutions and the MSC/Nastran code. For the problems IFM outperformed the existing methods. Superior IFM performance is attributed to simultaneous compliance of equilibrium equation and compatibility condition. MSC/Nastran organization expressed reluctance to accept the high fidelity IFM solutions. This report discusses the solutions to the examples. No inaccuracy was detected in the IFM solutions. A stiffness method code with a small programming effort can be improved to reap the many IFM benefits when implemented with the IFMD elements. Dr. Halford conducted a peer-review on the Integrated Force Method. Reviewers' response is included.

  16. High-Fidelity Piezoelectric Audio Device

    NASA Technical Reports Server (NTRS)

    Woodward, Stanley E.; Fox, Robert L.; Bryant, Robert G.

    2003-01-01

    ModalMax is a very innovative means of harnessing the vibration of a piezoelectric actuator to produce an energy efficient low-profile device with high-bandwidth high-fidelity audio response. The piezoelectric audio device outperforms many commercially available speakers made using speaker cones. The piezoelectric device weighs substantially less (4 g) than the speaker cones which use magnets (10 g). ModalMax devices have extreme fabrication simplicity. The entire audio device is fabricated by lamination. The simplicity of the design lends itself to lower cost. The piezoelectric audio device can be used without its acoustic chambers and thereby resulting in a very low thickness of 0.023 in. (0.58 mm). The piezoelectric audio device can be completely encapsulated, which makes it very attractive for use in wet environments. Encapsulation does not significantly alter the audio response. Its small size (see Figure 1) is applicable to many consumer electronic products, such as pagers, portable radios, headphones, laptop computers, computer monitors, toys, and electronic games. The audio device can also be used in automobile or aircraft sound systems.

  17. High-Fidelity Coding with Correlated Neurons

    PubMed Central

    da Silveira, Rava Azeredo; Berry, Michael J.

    2014-01-01

    Positive correlations in the activity of neurons are widely observed in the brain. Previous studies have shown these correlations to be detrimental to the fidelity of population codes, or at best marginally favorable compared to independent codes. Here, we show that positive correlations can enhance coding performance by astronomical factors. Specifically, the probability of discrimination error can be suppressed by many orders of magnitude. Likewise, the number of stimuli encoded—the capacity—can be enhanced more than tenfold. These effects do not necessitate unrealistic correlation values, and can occur for populations with a few tens of neurons. We further show that both effects benefit from heterogeneity commonly seen in population activity. Error suppression and capacity enhancement rest upon a pattern of correlation. Tuning of one or several effective parameters can yield a limit of perfect coding: the corresponding pattern of positive correlation leads to a ‘lock-in’ of response probabilities that eliminates variability in the subspace relevant for stimulus discrimination. We discuss the nature of this pattern and we suggest experimental tests to identify it. PMID:25412463

  18. Recommendations on Model Fidelity for Wind Turbine Gearbox Simulations: Preprint

    SciTech Connect

    Guo, Y.; Keller, J.; La Cava, W.; Austin, J.; Nejad, A. R.; Halse, C.; Bastard, L.; Helsen, J.

    2015-01-01

    This work investigates the minimum level of fidelity required to accurately simulate wind turbine gearboxes using state-of-the-art design tools. Excessive model fidelity including drivetrain complexity, gearbox complexity, excitation sources, and imperfections, significantly increases computational time, but may not provide a commensurate increase in the value of the results. Essential design parameters are evaluated, including the planetary load-sharing factor, gear tooth load distribution, and sun orbit motion. Based on the sensitivity study results, recommendations for the minimum model fidelities are provided.

  19. Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

    PubMed Central

    Thorne, Lucy; Ghurburrun, Elsa

    2016-01-01

    ABSTRACT Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo. We have previously shown that norovirus intrahost genetic diversity also influences viral pathogenesis using the murine norovirus model, as increasing viral mutation frequency using a mutagenic nucleoside resulted in clearance of a persistent infection in mice. Given the role of replication fidelity and genetic diversity in pathogenesis, we have now investigated whether polymerase fidelity can also impact virus transmission between susceptible hosts. We have identified a high-fidelity norovirus RNA-dependent RNA polymerase mutant (I391L) which displays delayed replication kinetics in vivo but not in cell culture. The I391L polymerase mutant also exhibited lower transmission rates between susceptible hosts than the wild-type virus and, most notably, another replication defective mutant that has wild-type levels of polymerase fidelity. These results provide the first experimental evidence that norovirus polymerase fidelity contributes to virus transmission between hosts and that maintaining diversity is important for the establishment of infection. This work supports the hypothesis that the reduced polymerase fidelity of the pandemic GII.4 human norovirus isolates may contribute to their global dominance. IMPORTANCE Virus replication fidelity and hence the intrahost genetic diversity of viral populations are known to be intricately linked to viral pathogenesis and tropism as well as to immune and antiviral escape during infection. In this study, we investigated whether changes in replication fidelity can impact the ability of a virus to transmit between susceptible hosts by the use of a mouse model for norovirus. We show that a variant encoding a high-fidelity polymerase is transmitted less efficiently between mice than the wild-type strain. This

  20. Is high fidelity human patient (mannequin) simulation, simulation of learning?

    PubMed

    McGarry, Denise; Cashin, Andrew; Fowler, Cathrine

    2014-08-01

    This paper explores the application of evaluation of high fidelity human patient (mannequin) simulation emerging in nursing education. The ramifications for use in mental health nursing are examined. A question is posed: Is high fidelity human patient (mannequin) simulation limited to being a "simulation of learning"? Explicit research that traces learning outcomes from mannequin, to clinical practice and hence consumer outcomes, is absent in mental health. Piecing together research from psychology addressing cognitive load theory and considering the capacity for learners to imitate desired behaviour without experiencing deep learning, the possibility is real that simulation of learning is the outcome of high fidelity human patient (mannequin) simulation applications to mental health nursing.

  1. Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo.

    PubMed

    Arias, Armando; Thorne, Lucy; Ghurburrun, Elsa; Bailey, Dalan; Goodfellow, Ian

    2016-01-01

    Intrahost genetic diversity and replication error rates are intricately linked to RNA virus pathogenesis, with alterations in viral polymerase fidelity typically leading to attenuation during infections in vivo. We have previously shown that norovirus intrahost genetic diversity also influences viral pathogenesis using the murine norovirus model, as increasing viral mutation frequency using a mutagenic nucleoside resulted in clearance of a persistent infection in mice. Given the role of replication fidelity and genetic diversity in pathogenesis, we have now investigated whether polymerase fidelity can also impact virus transmission between susceptible hosts. We have identified a high-fidelity norovirus RNA-dependent RNA polymerase mutant (I391L) which displays delayed replication kinetics in vivo but not in cell culture. The I391L polymerase mutant also exhibited lower transmission rates between susceptible hosts than the wild-type virus and, most notably, another replication defective mutant that has wild-type levels of polymerase fidelity. These results provide the first experimental evidence that norovirus polymerase fidelity contributes to virus transmission between hosts and that maintaining diversity is important for the establishment of infection. This work supports the hypothesis that the reduced polymerase fidelity of the pandemic GII.4 human norovirus isolates may contribute to their global dominance. IMPORTANCE Virus replication fidelity and hence the intrahost genetic diversity of viral populations are known to be intricately linked to viral pathogenesis and tropism as well as to immune and antiviral escape during infection. In this study, we investigated whether changes in replication fidelity can impact the ability of a virus to transmit between susceptible hosts by the use of a mouse model for norovirus. We show that a variant encoding a high-fidelity polymerase is transmitted less efficiently between mice than the wild-type strain. This constitutes

  2. Methodology development for evaluation of selective-fidelity rotorcraft simulation

    NASA Technical Reports Server (NTRS)

    Lewis, William D.; Schrage, D. P.; Prasad, J. V. R.; Wolfe, Daniel

    1992-01-01

    This paper addressed the initial step toward the goal of establishing performance and handling qualities acceptance criteria for realtime rotorcraft simulators through a planned research effort to quantify the system capabilities of 'selective fidelity' simulators. Within this framework the simulator is then classified based on the required task. The simulator is evaluated by separating the various subsystems (visual, motion, etc.) and applying corresponding fidelity constants based on the specific task. This methodology not only provides an assessment technique, but also provides a technique to determine the required levels of subsystem fidelity for a specific task.

  3. Flight simulator fidelity assessment in a rotorcraft lateral translation maneuver

    NASA Technical Reports Server (NTRS)

    Hess, R. A.; Malsbury, T.; Atencio, A., Jr.

    1992-01-01

    A model-based methodology for assessing flight simulator fidelity in closed-loop fashion is exercised in analyzing a rotorcraft low-altitude maneuver for which flight test and simulation results were available. The addition of a handling qualities sensitivity function to a previously developed model-based assessment criteria allows an analytical comparison of both performance and handling qualities between simulation and flight test. Model predictions regarding the existence of simulator fidelity problems are corroborated by experiment. The modeling approach is used to assess analytically the effects of modifying simulator characteristics on simulator fidelity.

  4. Mutation of the little finger domain in human DNA polymerase η alters fidelity when copying undamaged DNA.

    PubMed

    Beardslee, Renee A; Suarez, Samuel C; Toffton, Shannon M; McCulloch, Scott D

    2013-10-01

    DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8-dihydro-8-oxoguanine (8-oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently reported that β-strand 12 (amino acids 316-324) of the little finger region correctly positions the template strand with the catalytic core of the enzyme. The authors hypothesized that modification of β-strand 12 residues would disrupt correct enzyme-DNA alignment and alter pol η's activity and fidelity. To investigate this, the authors purified proteins containing the catalytic core of the polymerase, incorporated single amino acid changes to select β-strand 12 residues, and evaluated DNA synthesis activity for each pol η. Lesion bypass efficiencies and replication fidelities when copying DNA-containing cis-syn cyclobutane thymine-thymine dimer and 8-oxoG lesions were determined and compared with the corresponding values for the wild-type polymerase. The results confirm the importance of the β-strand in polymerase function and show that fidelity is most often altered when undamaged DNA is copied. Additionally, it is shown that DNA-protein contacts distal to the active site can significantly affect the fidelity of synthesis.

  5. Mutation of the Little Finger Domain in Human DNA Polymerase η Alters Fidelity When Copying Undamaged DNA

    PubMed Central

    Beardslee, Renee A.; Suarez, Samuel C.; Toffton, Shannon M.; McCulloch, Scott D.

    2014-01-01

    DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8-dihydro-8-oxoguanine (8-oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently reported that β-strand 12 (amino acids 316–324) of the little finger region correctly positions the template strand with the catalytic core of the enzyme. The authors hypothesized that modification of β-strand 12 residues would disrupt correct enzyme–DNA alignment and alter pol η’s activity and fidelity. To investigate this, the authors purified proteins containing the catalytic core of the polymerase, incorporated single amino acid changes to select β-strand 12 residues, and evaluated DNA synthesis activity for each pol η. Lesion bypass efficiencies and replication fidelities when copying DNA-containing cis-syn cyclobutane thymine-thymine dimer and 8-oxoG lesions were determined and compared with the corresponding values for the wild-type polymerase. The results confirm the importance of the β-strand in polymerase function and show that fidelity is most often altered when undamaged DNA is copied. Additionally, it is shown that DNA–protein contacts distal to the active site can significantly affect the fidelity of synthesis. PMID:23913529

  6. Fidelity between Gaussian mixed states with quantum state quadrature variances

    NASA Astrophysics Data System (ADS)

    Hai-Long, Zhang; Chun, Zhou; Jian-Hong, Shi; Wan-Su, Bao

    2016-04-01

    In this paper, from the original definition of fidelity in a pure state, we first give a well-defined expansion fidelity between two Gaussian mixed states. It is related to the variances of output and input states in quantum information processing. It is convenient to quantify the quantum teleportation (quantum clone) experiment since the variances of the input (output) state are measurable. Furthermore, we also give a conclusion that the fidelity of a pure input state is smaller than the fidelity of a mixed input state in the same quantum information processing. Project supported by the National Basic Research Program of China (Grant No. 2013CB338002) and the Foundation of Science and Technology on Information Assurance Laboratory (Grant No. KJ-14-001).

  7. Fidelity for kicked atoms with gravity near a quantum resonance.

    PubMed

    Dubertrand, Rémy; Guarneri, Italo; Wimberger, Sandro

    2012-03-01

    Kicked atoms under a constant Stark or gravity field are investigated for experimental setups with cold and ultracold atoms. The parametric stability of the quantum dynamics is studied using the fidelity. In the case of a quantum resonance, it is shown that the behavior of the fidelity depends on arithmetic properties of the gravity parameter. Close to a quantum resonance, the long-time asymptotics of the fidelity is studied by means of a pseudoclassical approximation introduced by Fishman et al. [J. Stat. Phys. 110, 911 (2003)]. The long-time decay of fidelity arises from the tunneling out of pseudoclassical stable islands, and a simple ansatz is proposed which satisfactorily reproduces the main features observed in numerical simulations.

  8. Fidelity for kicked atoms with gravity near a quantum resonance

    NASA Astrophysics Data System (ADS)

    Dubertrand, Rémy; Guarneri, Italo; Wimberger, Sandro

    2012-03-01

    Kicked atoms under a constant Stark or gravity field are investigated for experimental setups with cold and ultracold atoms. The parametric stability of the quantum dynamics is studied using the fidelity. In the case of a quantum resonance, it is shown that the behavior of the fidelity depends on arithmetic properties of the gravity parameter. Close to a quantum resonance, the long-time asymptotics of the fidelity is studied by means of a pseudoclassical approximation introduced by Fishman [J. Stat. Phys.JSTPBS0022-471510.1023/A:1022176306198 110, 911 (2003)]. The long-time decay of fidelity arises from the tunneling out of pseudoclassical stable islands, and a simple ansatz is proposed which satisfactorily reproduces the main features observed in numerical simulations.

  9. RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates.

    PubMed

    Kerr, S G; Anderson, K S

    1997-11-18

    The RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase has been investigated using pre-steady-state kinetics under single turnover conditions. In contrast to previous estimates of low replication fidelity of HIV-1 reverse transcriptase, the present study finds the enzyme to be more highly discriminating when an RNA/DNA template-primer is employed as compared with the corresponding DNA/DNA template-primer. The basis of this selectivity is due to extremely slow polymerization kinetics for incorporation of an incorrect deoxynucleotide. The maximum rates for misincorporation (kpol) of dGTP, dCTP, and dTTP opposite a template uridine were 0.2, 0.03, and 0.003 s-1, respectively. The equilibrium dissociation constants (Kd) for the incorrect nucleotide opposite a template uridine were 1.0, 1.1, and 0.7 mM for dGTP, dCTP, and dTTP, respectively. These kinetic values provide fidelity estimates of 26 000 for discrimination against dGTP, 176 000 for dCTP, and 1 x 10(6) for dTTP misincorporation at this position. Similar observations were obtained when incorrect nucleotide misincorporation was examined opposite a template adenine. Thus in a direct comparison of RNA/DNA and DNA/DNA template-primer substrates, HIV-1 RT exhibits approximately a 10-60-fold increase in fidelity. This study augments our current understanding of the similarities and differences of catalytic activity of HIV-1 reverse transcriptase using RNA and DNA substrates. Moreover, these studies lend further support for a model for nucleotide incorporation by HIV-1 reverse transcriptase involving a two-step binding mechanism governed by a rate-limiting conformational change for correct incorporation.

  10. Fidelity of the quantum δ-kicked accelerator.

    PubMed

    Shrestha, R K; Wimberger, S; Ni, J; Lam, W K; Summy, G S

    2013-02-01

    The sensitivity of the fidelity in the kicked rotor to an acceleration is experimentally and theoretically investigated. We used a Bose-Einstein condensate exposed to a sequence of pulses from a standing light wave followed by a single reversal pulse in which the standing wave was shifted by half a wavelength. The features of the fidelity "spectrum" as a function of acceleration are presented. This work may find applications in the measurement of temperature of an ultracold atomic sample.

  11. Measurement fidelity in the presence of coherent dynamics or dissipation

    NASA Astrophysics Data System (ADS)

    You, Jian-Qiang; Ashhab, S.; Nori, Franco

    2011-03-01

    We analyze the problem of a charge qubit probed by a quantum point contact when the measurement is concurrent with Hamiltonian-induced coherent dynamics or dissipation. This additional dynamics changes the state of the qubit before the measurement is completed. As a result, the measurement fidelity is reduced. We calculate the reduction in measurement fidelity in these cases. References: S. Ashhab, J. Q. You, and F. Nori, New J. Phys. 11, 083017 (2009); Phys. Scr. T137, 014005 (2009).

  12. High-Fidelity Aerodynamic Shape Optimization for Natural Laminar Flow

    NASA Astrophysics Data System (ADS)

    Rashad, Ramy

    To ensure the long-term sustainability of aviation, serious effort is underway to mitigate the escalating economic, environmental, and social concerns of the industry. Significant improvement to the energy efficiency of air transportation is required through the research and development of advanced and unconventional airframe and engine technologies. In the quest to reduce airframe drag, this thesis is concerned with the development and demonstration of an effective design tool for improving the aerodynamic efficiency of subsonic and transonic airfoils. The objective is to advance the state-of-the-art in high-fidelity aerodynamic shape optimization by incorporating and exploiting the phenomenon of laminar-turbulent transition in an efficient manner. A framework for the design and optimization of Natural Laminar Flow (NLF) airfoils is developed and demonstrated with transition prediction capable of accounting for the effects of Reynolds number, freestream turbulence intensity, Mach number, and pressure gradients. First, a two-dimensional Reynolds-averaged Navier-Stokes (RANS) flow solver has been extended to incorporate an iterative laminar-turbulent transition prediction methodology. The natural transition locations due to Tollmien-Schlichting instabilities are predicted using the simplified eN envelope method of Drela and Giles or, alternatively, the compressible form of the Arnal-Habiballah-Delcourt criterion. The boundary-layer properties are obtained directly from the Navier-Stokes flow solution, and the transition to turbulent flow is modeled using an intermittency function in conjunction with the Spalart-Allmaras turbulence model. The RANS solver is subsequently employed in a gradient-based sequential quadratic programming shape optimization framework. The laminar-turbulent transition criteria are tightly coupled into the objective and gradient evaluations. The gradients are obtained using a new augmented discrete-adjoint formulation for non-local transition

  13. Multi-fidelity approach to dynamics model calibration

    NASA Astrophysics Data System (ADS)

    Absi, Ghina N.; Mahadevan, Sankaran

    2016-02-01

    This paper investigates the use of structural dynamics computational models with multiple levels of fidelity in the calibration of system parameters. Different types of models may be available for the estimation of unmeasured system properties, with different levels of physics fidelity, mesh resolution and boundary condition assumptions. In order to infer these system properties, Bayesian calibration uses information from multiple sources (including experimental data and prior knowledge), and comprehensively quantifies the uncertainty in the calibration parameters. Estimating the posteriors is done using Markov Chain Monte Carlo sampling, which requires a large number of computations, thus making the use of a high-fidelity model for calibration prohibitively expensive. On the other hand, use of a low-fidelity model could lead to significant error in calibration and prediction. Therefore, this paper develops an approach for model parameter calibration with a low-fidelity model corrected using higher fidelity simulations, and investigates the trade-off between accuracy and computational effort. The methodology is illustrated for a curved panel located in the vicinity of a hypersonic aircraft engine, subjected to acoustic loading. Two models (a frequency response analysis and a full time history analysis) are combined to calibrate the damping characteristics of the panel.

  14. The Need for High Fidelity Lunar Regolith Simulants

    NASA Technical Reports Server (NTRS)

    Gaier, James R.

    2007-01-01

    The case is made for the need to have high fidelity lunar regolith simulants to verify the performance of structures and mechanisms to be used on the lunar surface. Minor constituents will in some cases have major consequences. Small amounts of sulfur in the regolith can poison catalysts, and metallic iron on the surface of nano-sized dust particles may cause a dramatic increase in its toxicity. So the definition of a high fidelity simulant is application dependent. For example, in situ resource utilization will require high fidelity in chemistry, meaning careful attention to the minor components and phases; but some other applications, such as the abrasive effects on suit fabrics, might be relatively insensitive to minor component chemistry. The lunar environment itself will change the surface chemistry of the simulant, so to have a high fidelity simulant at must be used in a high fidelity simulated environment to get a high fidelity simulation. Research must be conducted to determine how sensitive technologies will be to minor components and environmental factors before they can be dismissed as unimportant.

  15. Fidelity: An Essential Component of Evidence-Based Practice in Speech-Language Pathology

    ERIC Educational Resources Information Center

    Kaderavek, Joan N.; Justice, Laura M.

    2010-01-01

    Purpose: To provide a primer regarding treatment fidelity as it affects evidence-based practice (EBP) for speech-language pathologists. Method: This tutorial defines treatment fidelity, examines the role of treatment fidelity for speech-language pathologists, provides examples of fidelity measurement, and describes approaches for assessing…

  16. Testing the Feasibility of Fidelity Evaluation in a Multisite, Multiprogram Initiative

    ERIC Educational Resources Information Center

    Cornish, Disa Lubker; Losch, Mary E.; Avery, Mitchell

    2016-01-01

    Monitoring fidelity of implementation is a critical task when initiating evidence-based programs. This pilot study sought to identify best practices in a fidelity monitoring process and determine the feasibility of continuing a fidelity monitoring process with a multisite, multiprogram initiative. A fidelity log was created for each of 11…

  17. The Need for High Fidelity Lunar Regolith Simulants

    NASA Technical Reports Server (NTRS)

    Gaier, James R.

    2008-01-01

    The case is made for the need to have high fidelity lunar regolith simulants to verify the performance of structures, mechanisms, and processes to be used on the lunar surface. Minor constituents will in some cases have major consequences. Small amounts of sulfur in the regolith can poison catalysts, and metallic iron on the surface of nano-sized dust particles may cause a dramatic increase in its toxicity. So the definition of a high fidelity simulant is application-dependent. For example, in situ resource utilization will require high fidelity in chemistry, meaning careful attention to the minor components and phases; but some other applications, such as the abrasive effects on suit fabrics, might be relatively insensitive to minor component chemistry while abrasion of some metal components may be highly dependent on trace components. The lunar environment itself will change the surface chemistry of the simulant, so to have a high fidelity simulant it must be used in a high fidelity simulated environment to get an accurate simulation. Research must be conducted to determine how sensitive technologies will be to minor components and environmental factors before they can be dismissed as unimportant.

  18. Path integral approach to the quantum fidelity amplitude

    PubMed Central

    2016-01-01

    The Loschmidt echo is a measure of quantum irreversibility and is determined by the fidelity amplitude of an imperfect time-reversal protocol. Fidelity amplitude plays an important role both in the foundations of quantum mechanics and in its applications, such as time-resolved electronic spectroscopy. We derive an exact path integral formula for the fidelity amplitude and use it to obtain a series of increasingly accurate semiclassical approximations by truncating an exact expansion of the path integral exponent. While the zeroth-order expansion results in a remarkably simple, yet non-trivial approximation for the fidelity amplitude, the first-order expansion yields an alternative derivation of the so-called ‘dephasing representation,’ circumventing the use of a semiclassical propagator as in the original derivation. We also obtain an approximate expression for fidelity based on the second-order expansion, which resolves several shortcomings of the dephasing representation. The rigorous derivation from the path integral permits the identification of sufficient conditions under which various approximations obtained become exact. PMID:27140973

  19. Path integral approach to the quantum fidelity amplitude.

    PubMed

    Vaníček, Jiří; Cohen, Doron

    2016-06-13

    The Loschmidt echo is a measure of quantum irreversibility and is determined by the fidelity amplitude of an imperfect time-reversal protocol. Fidelity amplitude plays an important role both in the foundations of quantum mechanics and in its applications, such as time-resolved electronic spectroscopy. We derive an exact path integral formula for the fidelity amplitude and use it to obtain a series of increasingly accurate semiclassical approximations by truncating an exact expansion of the path integral exponent. While the zeroth-order expansion results in a remarkably simple, yet non-trivial approximation for the fidelity amplitude, the first-order expansion yields an alternative derivation of the so-called 'dephasing representation,' circumventing the use of a semiclassical propagator as in the original derivation. We also obtain an approximate expression for fidelity based on the second-order expansion, which resolves several shortcomings of the dephasing representation. The rigorous derivation from the path integral permits the identification of sufficient conditions under which various approximations obtained become exact.

  20. Development of High Fidelity, Fuel-Like Thermal Simulators for Non-Nuclear Testing

    SciTech Connect

    Bragg-Sitton, Shannon M.; Dickens, Ricky; Adams, Mike; Davis, Joe; Kapernick, Richard

    2007-01-30

    Non-nuclear testing can be a valuable tool in the development of a space nuclear power or propulsion system. In a non-nuclear test bed, electric heaters are used to simulate the heat from nuclear fuel. Work at the NASA Marshall Space Flight Center seeks to develop high fidelity thermal simulators that not only match the static power profile that would be observed in an operating, fueled nuclear reactor, but also match the dynamic fuel pin performance during feasible transients. Comparison between the fuel pins and thermal simulators is made at the outer fuel clad surface, which corresponds to the outer sheath surface in the thermal simulator. The thermal simulators that are currently being developed are designed to meet the geometric and power requirements of a proposed surface power reactor design, accommodate testing of various axial power profiles, and incorporate imbedded instrumentation. Static and dynamic fuel pin performances for a proposed reactor design have been determined using SINDA/FLUINT thermal analysis software, and initial comparison has been made between the expected nuclear performance and the performance of conceptual thermal simulator designs. Through a series of iterative analysis, a conceptual high fidelity design will be developed, followed by engineering design, fabrication, and testing to validate the overall design process. Although the resulting thermal simulator will be designed for a specific reactor concept, establishing this rigorous design process will assist in streamlining the thermal simulator development for other reactor concepts. This paper presents the current status of high fidelity thermal simulator design relative to a SNAP derivative reactor design that could be applied for Lunar surface power.

  1. Toward Right-Fidelity Rotorcraft Conceptual Design

    NASA Technical Reports Server (NTRS)

    Sinsay, Jeffrey D.; Johnson, Wayne

    2010-01-01

    utilized are driven by the timeline in which questions must be answered. This can range from quick "back-of-the-envelope" assessments of a configuration made in an afternoon, to more detailed tradespace explorations that can take upwards of a year to complete. A variety of spreadsheet based tools and conceptual design codes are currently in use. The in-house developed conceptual sizing code RC (Rotorcraft) has been the preferred tool of choice for CD activity for a number of years. Figure 2 illustrates the long standing coupling between RC and solid modeling tools for layout, as well as a number of ad-hoc interfaces with external analyses. RC contains a sizing routine that is built around the use of momentum theory for rotors, classic finite wing theory, a referred parameter engine model, and semi-emperical weight estimation techniques. These methods lend themselves to rapid solutions, measured in seconds and minutes. The successful use of RC, however requires careful consideration of model input parameters and judicious comparison with existing aircraft to avoid unjustified extrapolation of results. RC is in fact a legacy of a series of codes whose development started in the early 1970s, and is best suited to the study of conventional helicopters and XV-15 style tiltrotors. Other concepts have been analyzed with RC, but typically it became necessary to modify the source code and methods for each unique configuration. Recent activity has lead to the development of a new code, NASA Design and Analysis of Rotorcraft (NDARC). NDARC uses a similar level of analytical fidelity as RC, but is built on a new framework intended to improve modularity and ability to rapidly model a wider array of concepts. Critical to achieving this capability is the decomposition of the aircraft system into a series of fundamental components which can then be assembled to form a wide-array of configurations. The paper will provide an overview of NDARC and its capabilities.

  2. High-fidelity phototaxis in biflagellate algae

    NASA Astrophysics Data System (ADS)

    Leptos, Kyriacos; Chioccioli, Maurizio; Furlan, Silvano; Pesci, Adriana; Goldstein, Raymond

    2015-11-01

    The single-cell alga Chlamydomonas reinhardtii is a motile biflagellate that can swim towards light for its photosynthetic requirements, a behavior referred to as phototaxis. The cell responds upon light stimulation through its rudimentary eye - the eyespot - by changing the beating amplitude of its two flagella accordingly - a process called the photoresponse. All this occurs in a coordinated fashion as Chlamydomonas spins about its body axis while swimming, thus experiencing oscillating intensities of light. We use high-speed video microscopy to measure the flagellar dynamics of the photoresponse on immobilized cells and interpret the results with a mathematical model of adaptation similar to that used previously for Volvox. These results are incorporated into a model of phototactic steering to yield trajectories that are compared to those obtained by three-dimensional tracking. Implications of these results for the evolution of multicellularity in the Volvocales are discussed.

  3. COORDINATING DNA POLYMERASE TRAFFIC DURING HIGH AND LOW FIDELITY SYNTHESIS

    PubMed Central

    Sutton, Mark D.

    2009-01-01

    With the discovery that organisms possess multiple DNA polymerases (Pols) displaying different fidelities, processivities, and activities came the realization that mechanisms must exist to manage the actions of these diverse enzymes to prevent gratuitous mutations. Although many of the Pols encoded by most organisms are largely accurate, and participate in DNA replication and DNA repair, a sizeable fraction display a reduced fidelity, and act to catalyze potentially error-prone translesion DNA synthesis (TLS) past lesions that persist in the DNA. Striking the proper balance between use of these different enzymes during DNA replication, DNA repair, and TLS is essential for ensuring accurate duplication of the cell’s genome. This review highlights mechanisms that organisms utilize to manage the actions of their different Pols. A particular emphasis is placed on discussion of current models for how different Pols switch places with each other at the replication fork during high fidelity replication and potentially error-pone TLS. PMID:19540941

  4. Fidelity at Berezinskii-Kosterlitz-Thouless quantum phase transitions

    NASA Astrophysics Data System (ADS)

    Sun, G.; Kolezhuk, A. K.; Vekua, T.

    2015-01-01

    We clarify the long-standing controversy concerning the behavior of the ground-state fidelity in the vicinity of a quantum phase transition of the Berezinskii-Kosterlitz-Thouless type in one-dimensional systems. Contrary to the prediction based on the Gaussian approximation of the Luttinger-liquid approach, it is shown that the fidelity susceptibility does not diverge at the transition but has a cusplike peak χc-χ (λ ) ˜√{| λc-λ | } , where λ is a parameter driving the transition and χc is the peak value at the transition point λ =λc . Numerical claims of the logarithmic divergence of fidelity susceptibility with the system size (or temperature) are explained by logarithmic corrections due to marginal operators, which is supported by numerical calculations for large systems.

  5. The natural selection of fidelity in social learning

    PubMed Central

    Sperber, Dan

    2010-01-01

    Social learning mechanisms are usually assumed to explain both the spread and the persistence of cultural behavior. In a recent article, we showed that the fidelity of social learning commonly found in transmission chain experiments is not high enough to explain cultural stability. Here we want to both enrich and qualify this conclusion by looking at the case of song transmission in song birds, which can be faithful to the point of being true replication. We argue that this high fidelity results from natural selection pressure on cognitive mechanisms. This observation strengthens our main argument. Social learning mechanisms are unlikely to be faithful enough to explain cultural stability because they are generally selected not for high fidelity but for generalization and adjustment to the individual’s needs, capacities and situation. PMID:20798823

  6. Fiscal loss and program fidelity: impact of the economic downturn on HIV/STI prevention program fidelity.

    PubMed

    Catania, Joseph A; Dolcini, M Margaret; Gandelman, Alice A; Narayanan, Vasudha; McKay, Virginia R

    2014-03-01

    The economic downturn of 2007 created significant fiscal losses for public and private agencies conducting behavioral prevention. Such macro-economic changes may influence program implementation and sustainability. We examined how public and private agencies conducting RESPECT, a brief HIV/STI (sexually transmitted infection) counseling and testing intervention, adapted to fiscal loss and how these adaptations impacted program fidelity. We collected qualitative and quantitative data in a national sample of 15 agencies experiencing fiscal loss. Using qualitative analyses, we examined how program fidelity varied with different types of adaptations. Agencies reported three levels of adaptation: agency-level, program-level, and direct fiscal remedies. Private agencies tended to use direct fiscal remedies, which were associated with higher fidelity. Some agency-level adaptations contributed to reductions in procedural fit, leading to negative staff morale and decreased confidence in program effectiveness, which in turn, contributed to poor fidelity. Findings describe a "work stress pathway" that links program fiscal losses to poor staff morale and low program fidelity.

  7. Non-Natural Nucleotides as Probes for the Mechanism and Fidelity of DNA Polymerases

    PubMed Central

    Lee, Irene; Berdis, Anthony J.

    2009-01-01

    DNA is a remarkable macromolecule that functions primarily as the carrier of the genetic information of organisms ranging from viruses to bacteria to eukaryotes. The ability of DNA polymerases to efficiently and accurately replicate genetic material represents one of the most fundamental yet complex biological processes found in nature. The central dogma of DNA polymerization is that the efficiency and fidelity of this biological process is dependent upon proper hydrogen-bonding interactions between an incoming nucleotide and its templating partner. However, the foundation of this dogma has been recently challenged by the demonstration that DNA polymerases can effectively and, in some cases, selectively incorporate non-natural nucleotides lacking classic hydrogen-bonding capabilities into DNA. In this review, we describe the results of several laboratories that have employed a variety of non-natural nucleotide analogs to decipher the molecular mechanism of DNA polymerization. The use of various non-natural nucleotides has lead to the development of several different models that can explain how efficient DNA synthesis can occur in the absence of hydrogen-bonding interactions. These models include the influence of steric fit and shape complementarity, hydrophobicity and solvation energies, base-stacking capabilities, and negative selection as alternatives to rules invoking simple recognition of hydrogen bonding patterns. Discussions are also provided regarding how the kinetics of primer extension and exonuclease proofreading activities associated with high-fidelity DNA polymerases are influenced by the absence of hydrogen-bonding functional groups exhibited by non-natural nucleotides. PMID:19733263

  8. Development of the orpheus perfusion simulator for use in high-fidelity extracorporeal membrane oxygenation simulation.

    PubMed

    Lansdowne, William; Machin, David; Grant, David J

    2012-12-01

    Despite its life-sustaining potential, extracorporeal membrane oxygenation (ECMO) remains a complex treatment modality for which close teamwork is imperative with a high risk of adverse events leading to significant morbidity and mortality. The provision of adequate training and continuing education is key in mitigating these risks. Traditional training for ECMO has relied predominantly on didactic education and hands-on water drills. These methods may overemphasize cognitive skills while underemphasizing technical skills and completely ignoring team and human factor skills. These water drills are often static, lacking the time pressure, typical alarms, and a sense of urgency inherent to actual critical ECMO scenarios. Simulation-based training provides an opportunity for staff to develop and maintain technical proficiency in high-risk, infrequent events without fear of harming patients. In addition, it provides opportunities for interdisciplinary training and improved communication and teamwork among team members (1). Although simulation has become widely accepted for training of practitioners from many disciplines, there are currently, to our knowledge, no commercially available dedicated high-fidelity ECMO simulators. Our article describes the modification of the Orpheus Perfusion Simulator and its incorporation into a fully immersive, high-fidelity, point-of-care ECMO simulation model.

  9. High-fidelity teleportation between light and atoms

    SciTech Connect

    Hammerer, K.; Polzik, E. S.; Cirac, J. I.

    2006-12-15

    We show how high-fidelity quantum teleportation of light to atoms can be achieved in the same setup as was used in the recent experiment [J. Sherson et al., Nature 443, 557, 2006], where such an interspecies quantum state transfer was demonstrated for the first time. Our improved protocol takes advantage of the rich multimode entangled structure of the state of atoms and scattered light and requires simple postprocessing of homodyne detection signals and squeezed light in order to achieve fidelities up to 90% (85%) for teleportation of coherent (qubit) states under realistic experimental conditions. The remaining limitation is due to atomic decoherence and light losses.

  10. American woodcock winter distribution and fidelity to wintering areas

    USGS Publications Warehouse

    Diefenbach, D.R.; Derleth, E.L.; Vander Haegen, W.M.; Nichols, J.D.; Hines, J.E.

    1990-01-01

    We examined winter distribution and fidelity to wintering areas for the American Woodcock (Scolopax minor), which exhibits reversed, sexual size dimorphism. Band-recovery data revealed no difference in winter distributions of different age/sex classes for woodcock from the same breeding areas. Similarly, band recoveries from woodcock banded on wintering grounds revealed no difference in fidelity to wintering sites. Males may winter north of a latitude that is optimal for survival based on physiological considerations, but they gain a reproductive advantage if they are among the first to arrive on the breeding grounds. This may explain our results, which indicate males and females have similar distribution patterns during winter.

  11. Fidelity Decay in Trapped Bose-Einstein Condensates

    SciTech Connect

    Manfredi, G.; Hervieux, P.-A.

    2008-02-08

    The quantum coherence of a Bose-Einstein condensate is studied using the concept of quantum fidelity (Loschmidt echo). The condensate is confined in an elongated anharmonic trap and subjected to a small random potential such as that created by a laser speckle. Numerical experiments show that the quantum fidelity stays constant until a critical time, after which it drops abruptly over a single trap oscillation period. The critical time depends logarithmically on the number of condensed atoms and on the perturbation amplitude. This behavior may be observable by measuring the interference fringes of two condensates evolving in slightly different potentials.

  12. Estimates of movement and site fidelity using mark-resight data of wintering Canada geese

    USGS Publications Warehouse

    Hestbeck, J.B.; Nichols, J.D.; Malecki, R.A.

    1991-01-01

    Population ecologists have devoted disproportionate attention to the estimation and study of birth and death rates and far less effort to rates of movement. Movement and fidelity to wintering areas have important ecological and evolutionary implications for avian populations. Previous inferences about movement among and fidelity to wintering areas have been restricted by limitations of data and methodology. We use multiple observation data from a large-scale capture-resighting study of Canada Geese in the Atlantic flyway to estimate probabilities of returning to previous wintering locations and moving to new locations. Mark-resight data from 28,849 Canada Geese (Branta canadensis) banded woth individually coded neck bands in the mid-Atlantic (New York, Pennsylvania, New Jersey), Chesapeake (Delaware, Maryland, Virginia), and Carolinas (North and South Carolina) were used to estimate movement and site-fidelity. Two three-sample mark-resight models were developed and programmed using SURVIV to estimate the probability of moving among or remaining within these three wintering regions. The model (MV2) that incorporated tradition' or memory of previous wintering regions fit the data better than the model (MV1) that assumes that a first-order Markov chain described movement among regions. Considerable levels of movement occured among regions of the Atlantic flyway. The annual probability of remaining in the same region for two successive winters, used as a measure of site fidelity, was 0.710 plus or minus 0.016 (estimated mean plus or minus SE, 0.889 plus or minus 0.006, and 0.562 plus or minus 0.025, for the mid-Atlantic, Chesapeake, and Carolinas, respectively. The estimated probability of moving between years corresponded to changes in winter harshness. In warm years, geese moved north and in cold years, they moved south. Geese had a high probability of moving to and remaining in the Chesapeake. Annual changes in the movement probabilities did not correspond to annual

  13. Developing and Gathering Psychometric Evidence for a Fidelity Instrument: The Teaching Pyramid Observation Tool--Pilot Version

    ERIC Educational Resources Information Center

    Snyder, Patricia A.; Hemmeter, Mary Louise; Fox, Lise; Bishop, Crystal Crowe; Miller, M. David

    2013-01-01

    Fidelity assessment has received renewed attention in recent years, particularly as distinctions have been made in implementation science between intervention fidelity and implementation fidelity. Considering both types of fidelity has been recommended when developing fidelity instruments. In the present article, we describe development of the…

  14. High fidelity simulation of transcritical injection

    NASA Astrophysics Data System (ADS)

    Soteriou, Marios; Gao, Hui; Li, Xiaoyi; Davis, Dustin

    2012-11-01

    Transcritical injection of a multi-component fluid occurs in many practical applications such as diesel and rocket engines. In this type of injection a liquid fuel at a supercritical pressure but subcritical temperature, is introduced into an environment where conditions are supercritical. The convoluted physics of the transition from the subcritical to the supercritical state is linked to thermodynamic property variations and poses challenges to numerical simulation. For example, the temporary presence of surface tension implies that both the subcritical liquid-vapor interface and the transition boundary to supercritical fluid need to be captured. In this work, numerical simulation of a binary system of a subcritical liquid injecting into a supercritical, quiescent gaseous environment is performed. A coupled level set and volume of fluid method is adopted to capture the liquid-vapor interface, across which the continuity of mass and energy fluxes is preserved. The fluid state over the range of subcritical liquid to supercritical fluid is determined by incorporating the Peng-Robinson equation of state. To efficiently account for the sharp changes in properties near the liquid-vapor interface and the transition boundary to supercritical fluid, an adaptive mesh refinement technique is employed. Analysis of results focuses on the impact of vanishing surface tension as conditions transition from sub-critical to supercritical.

  15. Pyrophosphorolysis of CCA addition: implication for fidelity.

    PubMed

    Igarashi, Takao; Liu, Cuiping; Morinaga, Hironobu; Kim, Sangbumn; Hou, Ya-Ming

    2011-11-18

    In nucleic acid polymerization reaction, pyrophosphorolysis is the reversal of nucleotide addition, in which the terminal nucleotide is excised in the presence of inorganic pyrophosphate (PPi). The CCA enzymes are unusual RNA polymerases, which catalyze CCA addition to positions 74-76 at the tRNA 3' end without using a nucleic acid template. To better understand the reaction mechanism of CCA addition, we tested pyrophosphorolysis of CCA enzymes, which are divided into two structurally distinct classes. Here, we show that only class II CCA enzymes catalyze pyrophosphorolysis and that the reaction can initiate from all three CCA positions and proceed processively until the removal of nucleotide C74. Pyrophosphorolysis of class II enzymes establishes a fundamental difference from class I enzymes, and it is achieved only with the tRNA structure and with specific divalent metal ions. Importantly, pyrophosphorolysis enables class II enzymes to efficiently remove an incorrect A75 nucleotide from the 3' end, at a rate much faster than the rate of A75 incorporation, suggesting the ability to perform a previously unexpected quality control mechanism for CCA synthesis. Measurement of kinetic parameters of the class II Escherichia coli CCA enzyme reveals that the enzyme catalyzes pyrophosphorolysis slowly relative to the forward nucleotide addition and that it exhibits weak binding affinity to PPi relative to NTP, suggesting a mechanism in which PPi is rapidly released after each nucleotide addition as a driving force to promote the forward synthesis of CCA.

  16. Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase [delta

    SciTech Connect

    Swan, Michael K.; Johnson, Robert E.; Prakash, Louise; Prakash, Satya; Aggarwal, Aneel K.

    2009-09-25

    DNA polymerase {delta} (Pol {delta}) is a high-fidelity polymerase that has a central role in replication from yeast to humans. We present the crystal structure of the catalytic subunit of yeast Pol {delta} in ternary complex with a template primer and an incoming nucleotide. The structure, determined at 2.0-{angstrom} resolution, catches the enzyme in the act of replication, revealing how the polymerase and exonuclease domains are juxtaposed relative to each other and how a correct nucleotide is selected and incorporated. The structure also reveals the 'sensing' interactions near the primer terminus, which signal a switch from the polymerizing to the editing mode. Taken together, the structure provides a chemical basis for the bulk of DNA synthesis in eukaryotic cells and a framework for understanding the effects of cancer-causing mutations in Pol {delta}.

  17. Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme.

    PubMed

    Toh, Yukimatsu; Numata, Tomoyuki; Watanabe, Kazunori; Takeshita, Daijiro; Nureki, Osamu; Tomita, Kozo

    2008-07-23

    CCA-adding enzyme builds the 3'-end CCA of tRNA without a nucleic acid template. The mechanism for the maintenance of fidelity during the CCA-adding reaction remains elusive. Here, we present almost a dozen complex structures of the class I CCA-adding enzyme and tRNA mini-helices (mini-D(73)N(74), mini-D(73)N(74)C(75) and mini-D(73)C(74)N(75); D(73) is a discriminator nucleotide and N is either A, G, or U). The mini-D(73)N(74) complexes adopt catalytically inactive open forms, and CTP shifts the enzymes to the active closed forms and allows N(74) to flip for CMP incorporation. In contrast, unlike the catalytically active closed form of the mini-D(73)C(74)C(75) complex, the mini-D(73)N(74)C(75) and mini-D(73)C(74)N(75) complexes adopt inactive open forms. Only the mini-D(73)C(74)U(75) accepts AMP to a similar extent as mini-D(73)C(74)C(75), and ATP shifts the enzyme to a closed, active form and allows U(75) to flip for AMP incorporation. These findings suggest that the 3'-region of RNA is proofread, after two nucleotide additions, in the closed, active form of the complex at the AMP incorporation stage. This proofreading is a prerequisite for the maintenance of fidelity for complete CCA synthesis.

  18. Fidelity of the representation of value in decision-making

    PubMed Central

    Dowding, Ben A.

    2017-01-01

    The ability to make optimal decisions depends on evaluating the expected rewards associated with different potential actions. This process is critically dependent on the fidelity with which reward value information can be maintained in the nervous system. Here we directly probe the fidelity of value representation following a standard reinforcement learning task. The results demonstrate a previously-unrecognized bias in the representation of value: extreme reward values, both low and high, are stored significantly more accurately and precisely than intermediate rewards. The symmetry between low and high rewards pertained despite substantially higher frequency of exposure to high rewards, resulting from preferential exploitation of more rewarding options. The observed variation in fidelity of value representation retrospectively predicted performance on the reinforcement learning task, demonstrating that the bias in representation has an impact on decision-making. A second experiment in which one or other extreme-valued option was omitted from the learning sequence showed that representational fidelity is primarily determined by the relative position of an encoded value on the scale of rewards experienced during learning. Both variability and guessing decreased with the reduction in the number of options, consistent with allocation of a limited representational resource. These findings have implications for existing models of reward-based learning, which typically assume defectless representation of reward value. PMID:28248958

  19. The Heart of Implementation Fidelity: Instructional Design and Intent

    ERIC Educational Resources Information Center

    Kulo, Violet A.; Cates, Ward Mitchell

    2013-01-01

    Given that there is no universal way to measure implementation fidelity, instructional designers developing instructional innovations may find themselves faced with the challenge of determining the extent to which teachers' implementation of an instructional model is faithful. This article contends that a faithful implementation is one in…

  20. Fidelity: Snapshots of Implementation of a Curricular Intervention

    ERIC Educational Resources Information Center

    Foster, Lisa Hall

    2011-01-01

    Fidelity of implementation (FOI) is the extent to which delivery of an intervention adheres to the original intent of the program designer. FOI in educational studies is hindered by the lack of a universally agreed upon definition or set of criteria for measurement. With the increasing need for justification of reliability and validity of…

  1. Teachers Preparation Using TPACK when Fidelity of Treatment Is Defined

    ERIC Educational Resources Information Center

    Bos, Beth

    2011-01-01

    Teacher preparation for the 21st century deserves a front-end approach to addressing the use of technology in the learning environment. To study the effect of instructing with technology, pedagogy, and content knowledge (TPACK), teachers were asked to apply pedagogical, mathematical, and cognitive fidelity to technology used in an instructional…

  2. Fidelity of a human cell DNA replication complex.

    PubMed Central

    Roberts, J D; Kunkel, T A

    1988-01-01

    We have measured the fidelity of bidirectional, semiconservative DNA synthesis by a human DNA replication complex in vitro. Replication was performed by extracts of HeLa cells in the presence of simian virus 40 (SV40) large tumor antigen by using a double-stranded phage M13mp2 DNA template containing the SV40 origin of replication and either of two different target sequences for scoring mutations in the lacZ alpha-complementation gene, which encodes the alpha region (specifying the amino-terminal portion) of beta-galactosidase. Replicative synthesis was substantially more accurate than synthesis by the human DNA polymerase alpha-DNA primase complex purified from HeLa cell extracts by immunoaffinity chromatography, suggesting that additional factors or activities in the extract may increase fidelity during bidirectional replication. However, by using a sensitive opal codon reversion assay, single-base substitution errors were readily detected in the replication products at frequencies significantly higher than estimated spontaneous mutation rates in vivo. These data suggest that additional fidelity factors may be present during chromosomal replication in vivo and/or that the fidelity of replication alone does not account for the low spontaneous mutation rates in eukaryotes. Images PMID:3174620

  3. 77 FR 67689 - Fidelity Aberdeen Street Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... COMMISSION Fidelity Aberdeen Street Trust, et al.; Notice of Application November 6, 2012. AGENCY: Securities... certain joint arrangements (``Prior Order'').\\1\\ \\1\\ Colchester Street Trust, et al., Investment Company..., Colchester Street Trust, et al., Investment Company Act Release Nos. 23787 (Apr. 15, 1999) (notice) and...

  4. Learning Intercultural Communication Skills with Virtual Humans: Feedback and Fidelity

    ERIC Educational Resources Information Center

    Lane, H. Chad; Hays, Matthew Jensen; Core, Mark G.; Auerbach, Daniel

    2013-01-01

    In the context of practicing intercultural communication skills, we investigated the role of fidelity in a game-based, virtual learning environment as well as the role of feedback delivered by an intelligent tutoring system. In 2 experiments, we compared variations on the game interface, use of the tutoring system, and the form of the feedback.…

  5. Replicating an Intervention: The Tension between Fidelity and Adaptation

    ERIC Educational Resources Information Center

    Morrison, Diane M.; Hoppe, Marilyn J.; Gillmore, Mary Rogers; Kluver, Carisa; Higa, Darrel; Wells, Elizabeth A.

    2009-01-01

    Increased awareness of the importance of tailoring interventions to participants' cultures has focused attention on the limited generalizability of a single test of an intervention to determine efficacy. Adaptation is often necessary to replicate interventions across cultures. This produces a tension between fidelity to the original intervention…

  6. Technical Adequacy of the SWPBIS Tiered Fidelity Inventory

    ERIC Educational Resources Information Center

    McIntosh, Kent; Massar, Michelle M.; Algozzine, Robert F.; George, Heather Peshak; Horner, Robert H.; Lewis, Timothy J.; Swain-Bradway, Jessica

    2017-01-01

    Full and durable implementation of school-based interventions is supported by regular evaluation of fidelity of implementation. Multiple assessments have been developed to evaluate the extent to which schools are applying the core features of school-wide positive behavioral interventions and supports (SWPBIS). The "SWPBIS Tiered Fidelity…

  7. Competency: Does High Fidelity Simulation Make a Difference?

    ERIC Educational Resources Information Center

    Valente, Alice M.

    2010-01-01

    High fidelity simulation is a well documented adjunctive teaching method in medical and nurse practitioner programs, but few studies of effectiveness on this technology on the development of competency have emphasized pre-licensure associate degree level programs. This study explored student competency in the application of the nursing process…

  8. Fidelity of Implementation: Bringing Written Curriculum Materials into the Equation

    ERIC Educational Resources Information Center

    Superfine, Alison Castro; Marshall, Anne Marie; Kelso, Cathy

    2015-01-01

    Fidelity of curriculum implementation (FOI) is an important area of research because of the critical role it plays in understanding how and why curriculum materials work and how they can be improved. This analysis explores written features within the Math Trailblazers curriculum that may influence the ways teachers implement mathematics curriculum…

  9. Simulation System Fidelity Assessment at the Vertical Motion Simulator

    NASA Technical Reports Server (NTRS)

    Beard, Steven D.; Reardon, Scott E.; Tobias, Eric L.; Aponso, Bimal L.

    2013-01-01

    Fidelity is a word that is often used but rarely understood when talking about groundbased simulation. Assessing the cueing fidelity of a ground based flight simulator requires a comparison to actual flight data either directly or indirectly. Two experiments were conducted at the Vertical Motion Simulator using the GenHel UH-60A Black Hawk helicopter math model that was directly compared to flight data. Prior to the experiment the simulator s motion and visual system frequency responses were measured, the aircraft math model was adjusted to account for the simulator motion system delays, and the motion system gains and washouts were tuned for the individual tasks. The tuned motion system fidelity was then assessed against the modified Sinacori criteria. The first experiments showed similar handling qualities ratings (HQRs) to actual flight for a bob-up and sidestep maneuvers. The second experiment showed equivalent HQRs between flight and simulation for the ADS33 slalom maneuver for the two pilot participants. The ADS33 vertical maneuver HQRs were mixed with one pilot rating the flight and simulation the same while the second pilot rated the simulation worse. In addition to recording HQRs on the second experiment, an experimental Simulation Fidelity Rating (SFR) scale developed by the University of Liverpool was tested for applicability to engineering simulators. A discussion of the SFR scale for use on the Vertical Motion Simulator is included in this paper.

  10. Focus on Implementation: Assessing and Promoting Treatment Fidelity

    ERIC Educational Resources Information Center

    Collier-Meek, Melissa A.; Fallon, Lindsay M.; Sanetti, Lisa M. H.; Maggin, Daniel M.

    2013-01-01

    Implementation, or treatment fidelity, is the link between evidence-based interventions and changes in student outcomes. Although higher levels of implementation are generally associated with more efficient improvements in student outcomes, research indicates that many adults struggle to consistently implement student interventions. As school…

  11. Measuring the Fidelity of Re-ED Programs.

    ERIC Educational Resources Information Center

    Meadowcroft, Pamela; Cantrell, Mary Lynn; Cantrell, Robert P.

    2002-01-01

    The effectiveness of a comprehensive intervention like Re-ED (Reeducation of Emotional Disturbed Children) requires a clear definition of the essential components of the model. This article describes an ongoing process to create a program assessment tool for Re-ED. Program fidelity requires being able to specify precisely what is meant by certain…

  12. SWPBIS Tiered Fidelity Inventory. Version 2.1

    ERIC Educational Resources Information Center

    Algozzine, B.; Barrett, S.; Eber, L.; George, H.; Horner, R.; Lewis, T.; Putnam, B.; Swain-Bradway, J.; McIntosh, K.; Sugai, G.

    2014-01-01

    The purpose of the SWPBIS Tiered Fidelity Inventory (TFI) is to provide a valid, reliable, and efficient measure of the extent to which school personnel are applying the core features of school-wide positive behavioral interventions and supports (SWPBIS). The TFI is divided into three sections (Tier I: Universal SWPBIS Features; Tier II: Targeted…

  13. 77 FR 74112 - Fidelity Bond and Insurance Coverage

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... From the Federal Register Online via the Government Publishing Office NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 713 RIN 3133-AD98 Fidelity Bond and Insurance Coverage AGENCY: National Credit Union... Credit unions, Insurance, Reporting and recordkeeping requirements. By the National Credit...

  14. Experiential Fidelity: Leveraging the Mind to Improve the VR Experience

    NASA Astrophysics Data System (ADS)

    Beckhaus, Steffi; Lindeman, Robert W.

    Much of Virtual Reality (VR) is about creating environments that are believable. But though the visual and audio experiences we provide today are already of a rather high sensory fidelity, there is still something lacking; something hinders us from fully buying into the worlds we experience through VR technology. We introduce the notion of Experiential Fidelity, which is an attempt to create a deeper sense of presence by carefully designing the user experience. We suggest to guide the users' frame of mind in a way that their expectations, attitude, and attention are aligned with the actual VR experience, and that the user's own imagination is stimulated to complete the experience. This work was inspired by a collection of personal magic moments and factors that were named by leading researchers in VR. We present those magic moments and some thoughts on how we can tap into experiential fidelity. We propose to do this not through technological means, but rather through the careful use of suggestion and allusion. By priming the user's mind prior to exposure to our virtual worlds, we can assist her in entering a mental state that is more willing to believe, even using the limited actual fidelity available today.

  15. High Fidelity: Investing in Evaluation Training. Ask the Team

    ERIC Educational Resources Information Center

    Fetters, Jenni

    2013-01-01

    High-quality training is a crucial investment in establishing and maintaining implementation fidelity as well as building educators' trust in the new process. Training approaches for educator evaluation vary both in format (i.e., how it's delivered) and content (i.e., what is provided). Train-the-trainer sessions, online professional learning…

  16. Multi-fidelity global design optimization including parallelization potential

    NASA Astrophysics Data System (ADS)

    Cox, Steven Edward

    The DIRECT global optimization algorithm is a relatively new space partitioning algorithm designed to determine the globally optimal design within a designated design space. This dissertation examines the applicability of the DIRECT algorithm to two classes of design problems: unimodal functions where small amplitude, high frequency fluctuations in the objective function make optimization difficult; and multimodal functions where multiple local optima are formed by the underlying physics of the problem (as opposed to minor fluctuations in the analysis code). DIRECT is compared with two other multistart local optimization techniques on two polynomial test problems and one engineering conceptual design problem. Three modifications to the DIRECT algorithm are proposed to increase the effectiveness of the algorithm. The DIRECT-BP algorithm is presented which alters the way DIRECT searches the neighborhood of the current best point as optimization progresses. The algorithm reprioritizes which points to analyze at each iteration. This is to encourage analysis of points that surround the best point but that are farther away than the points selected by the DIRECT algorithm. This increases the robustness of the DIRECT search and provides more information on the characteristics of the neighborhood of the point selected as the global optimum. A multifidelity version of the DIRECT algorithm is proposed to reduce the cost of optimization using DIRECT. By augmenting expensive high-fidelity analysis with cheap low-fidelity analysis, the optimization can be performed with fewer high-fidelity analyses. Two correction schemes are examined using high- and low-fidelity results at one point to correct the low-fidelity result at a nearby point. This corrected value is then used in place of a high-fidelity analysis by the DIRECT algorithm. In this way the number of high-fidelity analyses required is reduced and the optimization became less expensive. Finally the DIRECT algorithm is

  17. Engineering High-Fidelity Residue Separations for Selective Harvest

    SciTech Connect

    Kevin L. Kenney; Christopher T. Wright; Reed L. Hoskinson; J. Rochard Hess; David J. Muth, Jr.

    2006-07-01

    Composition and pretreatment studies of corn stover and wheat stover anatomical fractions clearly show that some corn and wheat stover anatomical fractions are of higher value than others as a biofeedstock. This premise, along with soil sustainability and erosion control concerns, provides the motivation for the selective harvest concept for separating and collecting the higher value residue fractions in a combine during grain harvest. This study recognizes the analysis of anatomical fractions as theoretical feedstock quality targets, but not as practical targets for developing selective harvest technologies. Rather, practical quality targets were established that identified the residue separation requirements of a selective harvest combine. Data are presented that shows that a current grain combine is not capable of achieving the fidelity of residue fractionation established by the performance targets. However, using a virtual engineering approach, based on an understanding of the fluid dynamics of the air stream separation, the separation fidelity can be significantly improved without significant changes to the harvester design. A virtual engineering model of a grain combine was developed and used to perform simulations of the residue separator performance. The engineered residue separator was then built into a selective harvest test combine, and tests performed to evaluate the separation fidelity. Field tests were run both with and without the residue separator installed in the test combine, and the chaff and straw residue streams were collected during harvest of Challis soft white spring wheat. The separation fidelity accomplished both with and without the residue separator was quantified by laboratory screening analysis. The screening results showed that the engineered baffle separator did a remarkable job of effecting high-fidelity separation of the straw and chaff residue streams, improving the chaff stream purity and increasing the straw stream yield.

  18. Examining the Fidelity of Climate model via Shadowing Time

    NASA Astrophysics Data System (ADS)

    Du, H.; Smith, L. A.

    2015-12-01

    Fully fledged climate models provide the best available simulations for reflecting the future, yet we have scant insight into their fidelity, in particular as to the duration into the future at which the real world should be expected to evolve in a manner today's models cannot foresee. We know now that our best available models are not adequate for many sought after purposes. To throw some light on the maximum fidelity expected from a given generation of models, and thereby aid both policy making and model development, we can test the weaknesses of a model as a dynamical system to get an informed idea of its potential applicability at various lead times. Shadowing times reflect the duration on which a GCM reflects the observations; extracting the shortcomings of the model which limit shadowing times allows informed speculation regarding the fidelity of the model in the future. More specifically, the relevant phenomena limiting model fidelity can be learned by identifying the reasons models cannot shadow; the time scales on which feedbacks on the system (which are not active in the model) are likely to result in model irrelevance can be discerned. The methodology is developed in the "low dimensional laboratory" of relatively simple dynamical systems, for example Lorenz 95 systems. The results are presented in Lorenz 95 systems, high dimensional fluid dynamical simulations of rotating annulus and GCMs. There are severe limits on the light shadowing experiments can shine on GCM predictions. Never the less, they appear to be one of the brightest lights we can shine to illuminate the likely fidelity of GCM extrapolations into the future.

  19. Modeling movement and fidelity of American black ducks

    USGS Publications Warehouse

    Zimpfer, N.L.; Conroy, M.J.

    2006-01-01

    Spatial relationships among stocks of breeding waterfowl can be an important component of harvest management. Prediction and optimal harvest management under adaptive harvest management (AHM) requires information on the spatial relationships among breeding populations (fidelity and inter-year exchange), as well as rates of movements from breeding to harvest regions. We used band-recovery data to develop a model to estimate probabilities of movement for American black ducks (Anas rubripes) among 3 Canadian breeding strata and 6 harvest regions (3 in Canada, and 3 in the United States) over the period 1965-1998. Model selection criteria suggested that models containing area-, year-, and age-specific recovery rates with area- and sex-specific movement rates were the best for modeling movement. Movement by males to southern harvest areas was variable depending on the originating area. Males from the western breeding area predominantly moved to the Mississippi Flyway or southern Atlantic Flyway (??ij = 0.353, SE = 0.0187 and ??ij = 0.473, SE = 0.037, respectively), whereas males that originated in the eastern and central breeding strata moved to the northern Atlantic flyway (??ij = 0.842, SE = 0.010 and ??ij = 0.578, SE = 0.0222, respectively). We used combined recoveries and recaptures in Program MARK to estimate fidelity to the 3 Canadian breeding strata. Information criteria identified a model containing sex- and age-specific fidelity for black ducks. Estimates of fidelity were 0.9695 (SE = 0.0249) and 0.9554 (SE = 0.0434) for adult males and females, respectively. Estimates of fidelity for juveniles were slightly lower at 0.9210 (SE = 0.0931) and 0.8870 (SE = 0.0475) for males and females, respectively. These models have application to the development of spatially stratified black duck harvest management models for use in AHM.

  20. Towards efficient uncertainty quantification in complex and large-scale biomechanical problems based on a Bayesian multi-fidelity scheme.

    PubMed

    Biehler, Jonas; Gee, Michael W; Wall, Wolfgang A

    2015-06-01

    In simulation of cardiovascular processes and diseases patient-specific model parameters, such as constitutive properties, are usually not easy to obtain. Instead of using population mean values to perform "patient-specific" simulations, thereby neglecting the inter- and intra-patient variations present in these parameters, these uncertainties have to be considered in the computational assessment. However, due to limited computational resources and several shortcomings of traditional uncertainty quantification approaches, parametric uncertainties, modeled as random fields, have not yet been considered in patient-specific, nonlinear, large-scale, and complex biomechanical applications. Hence, the purpose of this study is twofold. First, we present an uncertainty quantification framework based on multi-fidelity sampling and Bayesian formulations. The key feature of the presented method is the ability to rigorously exploit and incorporate information from an approximate, low fidelity model. Most importantly, response statistics of the corresponding high fidelity model can be computed accurately even if the low fidelity model provides only a very poor approximation. The approach merely requires that the low fidelity model and the corresponding high fidelity model share a similar stochastic structure, i.e., dependence on the random input. This results in a tremendous flexibility in choice of the approximate model. The flexibility and capabilities of the framework are demonstrated by performing uncertainty quantification using two patient-specific, large-scale, nonlinear finite element models of abdominal aortic aneurysms. One constitutive parameter of the aneurysmatic arterial wall is modeled as a univariate three-dimensional, non-Gaussian random field, thereby taking into account inter-patient as well as intra-patient variations of this parameter. We use direct Monte Carlo to evaluate the proposed method and found excellent agreement with this reference solution

  1. High fidelity frictional models for MEMS.

    SciTech Connect

    Carpick, Robert W.; Reedy, Earl David, Jr.; Bitsie, Fernando; de Boer, Maarten Pieter; Corwin, Alex David; Ashurst, William Robert; Jones, Reese E.; Subhash, Ghatu S.; Street, Mark D.; Sumali, Anton Hartono; Antoun, Bonnie R.; Starr, Michael James; Redmond, James Michael; Flater, Erin E.

    2004-10-01

    roughness in such an analysis by using a homogenized contact and friction models. AFM measurements were made to determine statistical information on polysilicon surfaces with different roughnesses, and this data was used as input to a homogenized, multi-asperity contact model (the classical Greenwood and Williamson model). Extensions of the Greenwood and Williamson model are also discussed: one incorporates the effect of adhesion while the other modifies the theory so that it applies to the case of relatively few contacting asperities.

  2. A Method of Surrogate Model Construction which Leverages Lower-Fidelity Information using Space Mapping Techniques

    DTIC Science & Technology

    2014-03-27

    A Method of Surrogate Model Construction which Leverages Lower- Fidelity Information using Space Mapping Techniques THESIS Jason W. Thomas, Capt, USAF...Lower- Fidelity Information using Space Mapping Techniques THESIS Presented to the Faculty Department of Aeronautics and Astronautics Graduate School of...RELEASE; DISTRIBUTION IS UNLIMITED A Method of Surrogate Model Construction which Leverages Lower- Fidelity Information using Space Mapping Techniques

  3. Flow tracing fidelity of scattering aerosol in laser Doppler velocimetry

    NASA Technical Reports Server (NTRS)

    Mazumder, M. K.; Kirsch, K. J.

    1974-01-01

    An experimental method for determinating the flow tracing fidelity of a scattering aerosol used in laser Doppler velocimeters was developed with particular reference to the subsonic turbulence measurements. The method employs the measurement of the dynamic response of a flow seeding aerosol excited by acoustic waves. The amplitude and frequency of excitation were controlled to simulate the corresponding values of fluid turbulence components. Experimental results are presented on the dynamic response of aerosols over the size range from 0.1 to 2.0 microns in diameter and over the frequency range 100 Hz to 100 kHz. It was observed that unit density spherical scatterers with diameters of 0.2 microns followed subsonic air turbulence frequency components up to 100 kHz with 98 percent fidelity.

  4. Flow tracing fidelity of scattering aerosol in laser Doppler velocimetry

    NASA Technical Reports Server (NTRS)

    Mazumder, M. K.; Kirsch, K. J.

    1975-01-01

    An experimental method for the determination of the flow-tracing fidelity of a scattering aerosol used in laser Doppler velocimeters was developed with particular reference to the subsonic turbulence measurements. The method employs the measurement of the dynamic response of a flow-seeding aerosol excited by acoustic waves. The amplitude and frequency of excitation were controlled in order to simulate the corresponding values of fluid turbulence components. Experimental results are presented on the dynamic response of aerosols over the size range from 0.1 to 2.0 microns in diam and over the frequency range 100 Hz to 100 kHz. It was observed that unit-density spherical scatterers with diameters of 0.2 micron followed subsonic air turbulence frequency components up to 100 kHz with 98% fidelity.

  5. Small convolution kernels for high-fidelity image restoration

    NASA Technical Reports Server (NTRS)

    Reichenbach, Stephen E.; Park, Stephen K.

    1991-01-01

    An algorithm is developed for computing the mean-square-optimal values for small, image-restoration kernels. The algorithm is based on a comprehensive, end-to-end imaging system model that accounts for the important components of the imaging process: the statistics of the scene, the point-spread function of the image-gathering device, sampling effects, noise, and display reconstruction. Subject to constraints on the spatial support of the kernel, the algorithm generates the kernel values that restore the image with maximum fidelity, that is, the kernel minimizes the expected mean-square restoration error. The algorithm is consistent with the derivation of the spatially unconstrained Wiener filter, but leads to a small, spatially constrained kernel that, unlike the unconstrained filter, can be efficiently implemented by convolution. Simulation experiments demonstrate that for a wide range of imaging systems these small kernels can restore images with fidelity comparable to images restored with the unconstrained Wiener filter.

  6. Comparison of fusion imageries with spectral fidelity using SPOT5

    NASA Astrophysics Data System (ADS)

    Chen, Weitao; Zhang, Lin; Zhang, Zhi; Wang, Yanxin

    2009-10-01

    Gram-Schmidt and Ehlers fusion, which are well known for spectral fidelity, are described. Selecting a sandrock mine using SPOT5 as study area, spectral fidelity and high spatial information gain are used to assess the two fusion methods, which are compared with multiplication and Andorr fusion. In the whole, the Gram-Schmidt method is the best, preserving highly the original spectral information, and can provide spectrum control foundation for interpreting mine targets in the complex geology environment. Ehlers method is the second. Then Andorr method is the third, and it has the highest spatial information gain, but high frequency information is enlarged excessively, effecting on the identification of mine exploitation state. The multiplication method is the worst, because it loses the high and low frequency information, which is the most important for mine targets recognition.

  7. Sequential kriging optimization using multiple-fidelity evaluations

    SciTech Connect

    Huang, Deng; Allen, T. T.; Notz, W. I.; Miller, R. A.

    2006-11-01

    When cost per evaluation on a system of interest is high, surrogate systems can provide cheaper but lower-fidelity information. In the proposed extension of the sequential kriging optimization method, surrogate systems are exploited to reduce the total evaluation cost. The method utilizes data on all systems to build a kriging metamodel that provides a global prediction of the objective function and a measure of prediction uncertainty. The location and fidelity level of the next evaluation are selected by maximizing an augmented expected improvement function, which is connected with the evaluation costs. The proposed method was applied to test functions from the literature and a metal-forming process design problem via finite element simulations. The method manifests sensible search patterns, robust performance, and appreciable reduction in total evaluation cost as compared to the original method.

  8. Sequential kriging optimization using multiple-fidelity evaluations

    SciTech Connect

    Huang, Deng; Allen, T. T.; Notz, W. I.; Miller, R. A.

    2006-05-23

    When cost per evaluation on a system of interest is high, surrogate systems can provide cheaper but lower-fidelity information. In the proposed extension of the sequential kriging optimization method, surrogate systems are exploited to reduce the total evaluation cost. The method utilizes data on all systems to build a kriging metamodel that provides a global prediction of the objective function and a measure of prediction uncertainty. The location and fidelity level of the next evaluation are selected by maximizing an augmented expected improvement function, which is connected with the evaluation costs. The proposed method was applied to test functions from the literature and a metal-forming process design problem via finite element simulations. The method manifests sensible search patterns, robust performance, and appreciable reduction in total evaluation cost as compared to the original method.

  9. Multi-fidelity construction of explicit boundaries: Application to aeroelasticity

    NASA Astrophysics Data System (ADS)

    Dribusch, Christoph

    SVM only requires classification of training samples as feasible or infeasible, the presence of discontinuities in the simulation results does not affect the proposed algorithm. For the same reason, multiple failure modes such as aeroelastic stability, maximum stress or geometric constraints, may be represented by a single SVM predictor. Often, multiple models are available to simulate a given design at different levels of fidelity and small improvements in accuracy may increase simulation cost by an order of magnitude. In many cases, a lower-fidelity model will classify a case correctly as feasible or infeasible. Therefore a multi-fidelity algorithm is proposed that takes advantage of lower-fidelity models when appropriate to minimize the overall computational burden of training the SVM. To this end, the algorithm combines the concepts of adaptive sampling and multi-fidelity analysis to iteratively select not only the training samples, but also the appropriate level of fidelity for evaluation. The proposed algorithm, referred to as multi-fidelity explicit design space decomposition (MF-EDSD), is demonstrated on various models of aeroelastic stability to either build the stability boundary and/or to perform design optimization. The aeroelastic models range from linear and nonlinear analytical models to commercial software (ZAERO) and represent divergence, flutter, and limit cycle oscillation instabilities. Additional analytical test problems have the advantage that the accuracy of the SVM predictor and the convergence to optimal designs are more easily verified. On the other hand the more sophisticated models demonstrate the applicability to real aerospace applications where the solutions are not known a priori. In conclusion, the presented MF-EDSD algorithm is well suited for approximating stability boundaries associated with aeroelastic instabilities in high-dimensional parameter spaces. The adaptive selection of training samples and use of multi-fidelity models

  10. Enhancing teleportation fidelity by means of weak measurements or reversal

    SciTech Connect

    Qiu, Liang; Tang, Gang; Yang, Xianqing; Wang, Anmin

    2014-11-15

    The enhancement of teleportation fidelity by weak measurement or quantum measurement reversal is investigated. One qubit of a maximally entangled state undergoes the amplitude damping, and the subsequent application of weak measurement or quantum measurement reversal could improve the teleportation fidelity beyond the classical region. The improvement could not be attributed to the increasing of entanglement, quantum discord, classical correlation or total correlation. We declare that it should be owed to the probabilistic nature of the method. - Highlights: • The method’s probabilistic nature should be responsible for the improvement. • Quantum or classical correlation cannot explain the improvement. • The receiver cannot apply weak measurements. • The sender’s quantum measurement reversal is only useful for |Ψ{sup ±}〉.

  11. Improving fidelity in atomic state teleportation via cavity decay

    SciTech Connect

    Chimczak, Grzegorz; Tanas, Ryszard

    2007-02-15

    We propose a modified protocol of atomic state teleportation for the scheme proposed by Bose et al. [Phys. Rev. Lett. 83, 5158 (1999)]. The modified protocol involves an additional stage in which quantum information distorted during the first stage is fully recovered by a compensation of the damping factor. The modification makes it possible to obtain a high fidelity of teleported state for cavities that are much worse than that required in the original protocol, i.e., their decay rates can be over 25 times larger. The improvement in the fidelity is possible at the expense of lowering the probability of success. We show that the modified protocol is robust against dark counts.

  12. Enhancing the fidelity of two-qubit gates by measurements

    NASA Astrophysics Data System (ADS)

    Gefen, Tuvia; Cohen, Daniel; Cohen, Itsik; Retzker, Alex

    2017-03-01

    Dynamical decoupling techniques are the method of choice for increasing gate fidelities. While these methods have produced very impressive results in terms of decreasing local noise and increasing the fidelities of single-qubit operations, dealing with the noise of two-qubit gates has proven more challenging. The main obstacle is that the noise time scale is shorter than the two-qubit gate itself, so that refocusing methods do not work. We present a measurement- and feedback-based method to suppress two-qubit-gate noise, which cannot be suppressed by conventional methods. We analyze in detail this method for an error model, which is relevant for trapped-ion quantum information.

  13. Proofreading genotyping assays mediated by high fidelity exo+ DNA polymerases.

    PubMed

    Zhang, Jia; Li, Kai; Pardinas, Jose R; Sommer, Steve S; Yao, Kai-Tai

    2005-02-01

    DNA polymerases with 3'-5' proofreading function mediate high fidelity DNA replication but their application for mutation detection was almost completely neglected before 1998. The obstacle facing the use of exo(+) polymerases for mutation detection could be overcome by primer-3'-termini modification, which has been tested using allele-specific primers with 3' labeling, 3' exonuclease-resistance and 3' dehydroxylation modifications. Accordingly, three new types of single nucleotide polymorphism (SNP) assays have been developed to carry out genome-wide genotyping making use of the fidelity advantage of exo(+) polymerases. Such SNP assays might also provide a novel approach for re-sequencing and de novo sequencing. These new mutation detection assays are widely adaptable to a variety of platforms, including real-time PCR, multi-well plate and microarray technologies. Application of exo(+) polymerases to genetic analysis could accelerate the pace of personalized medicine.

  14. Fidelity and quantum phase transition for the Heisenberg chain with next-nearest-neighbor interaction.

    PubMed

    Chen, Shu; Wang, Li; Gu, Shi-Jian; Wang, Yupeng

    2007-12-01

    In this paper, we investigate the fidelity for the Heisenberg chain with the next-nearest-neighbor interaction (or the J1-J2 model) and analyze its connections with quantum phase transition. We compute the fidelity between the ground states and find that the phase transition point of the J1-J2 model cannot be well characterized by the ground-state fidelity for finite-size systems. Instead, we introduce and calculate the fidelity between the first excited states. Our results show that the quantum transition can be well characterized by the fidelity of the first excited state even for a small-size system.

  15. High Fidelity Quantum Gates via Analytically Solvable Pulses

    DTIC Science & Technology

    2012-06-06

    generally allow for higher fidelities as compared to their unchirped coun- terparts, an effect reminiscent of the robust population transfer to an...2 + λ), the effective pulse area is the same as that of the RZ sech pulse, so that for Ω/σ = integer, the induced evolution is cyclic. I focus on...larger detuning required for the same phase. Since the detuning is large, from a qualitative effective Rabi frequency argument, the relative

  16. Towards robust dynamical decoupling and high fidelity adiabatic quantum computation

    NASA Astrophysics Data System (ADS)

    Quiroz, Gregory

    Quantum computation (QC) relies on the ability to implement high-fidelity quantum gate operations and successfully preserve quantum state coherence. One of the most challenging obstacles for reliable QC is overcoming the inevitable interaction between a quantum system and its environment. Unwanted interactions result in decoherence processes that cause quantum states to deviate from a desired evolution, consequently leading to computational errors and loss of coherence. Dynamical decoupling (DD) is one such method, which seeks to attenuate the effects of decoherence by applying strong and expeditious control pulses solely to the system. Provided the pulses are applied over a time duration sufficiently shorter than the correlation time associated with the environment dynamics, DD effectively averages out undesirable interactions and preserves quantum states with a low probability of error, or fidelity loss. In this study various aspects of this approach are studied from sequence construction to applications of DD to protecting QC. First, a comprehensive examination of the error suppression properties of a near-optimal DD approach is given to understand the relationship between error suppression capabilities and the number of required DD control pulses in the case of ideal, instantaneous pulses. While such considerations are instructive for examining DD efficiency, i.e., performance vs the number of control pulses, high-fidelity DD in realizable systems is difficult to achieve due to intrinsic pulse imperfections which further contribute to decoherence. As a second consideration, it is shown how one can overcome this hurdle and achieve robustness and recover high-fidelity DD in the presence of faulty control pulses using Genetic Algorithm optimization and sequence symmetrization. Thirdly, to illustrate the implementation of DD in conjunction with QC, the utilization of DD and quantum error correction codes (QECCs) as a protection method for adiabatic quantum

  17. Retinex Image Processing: Improved Fidelity To Direct Visual Observation

    NASA Technical Reports Server (NTRS)

    Jobson, Daniel J.; Rahman, Zia-Ur; Woodell, Glenn A.

    1996-01-01

    Recorded color images differ from direct human viewing by the lack of dynamic range compression and color constancy. Research is summarized which develops the center/surround retinex concept originated by Edwin Land through a single scale design to a multi-scale design with color restoration (MSRCR). The MSRCR synthesizes dynamic range compression, color constancy, and color rendition and, thereby, approaches fidelity to direct observation.

  18. Advancement of estimation fidelity in continuous quantum measurement

    NASA Astrophysics Data System (ADS)

    Diósi, Lajos

    2002-03-01

    We estimate an unknown qubit from the long sequence of n random polarization measurements of precision Δ. Using the standard Ito stochastic equations of the a posteriori state in the continuous measurement limit, we calculate the advancement of fidelity. We show that the standard optimum value 2/3 is achieved asymptotically for n ≫ Δ2/96 ≫ 1. We append a brief derivation of novel Ito equations for the estimate state.

  19. Single High Fidelity Geometric Data Sets for LCM - Model Requirements

    DTIC Science & Technology

    2006-11-01

    Defence R&D Canada – Atlantic DEFENCE DÉFENSE & Single High Fidelity Geometric Data Sets for LCM – Model Requirements D. Brennan T. Koko K. Mackay M...Brennan T. Koko K. Mackay M. Norwood S. Tobin E. Teng J. Wallace Martec Limited Martec Limited 1888 Brunswick Street, Suite 400 Halifax...result in SPMs for use in LCM analysis of existing and future classes of Canadian naval vessels. D. Brennan, T. Koko , K. Mackay, M. Norwood, S. Tobin, E

  20. Free Energy Gap and Statistical Thermodynamic Fidelity of DNA Codes

    DTIC Science & Technology

    2007-10-01

    reverse-complement unless otherwise stated. For strand x, let Nx denote its complement. A (perfect) Watson - Crick duplex is the joining of complement...is possible for complementary sequences to form a non-perfectly aligned duplex, we will call any x W Nx duplex a Watson - Crick (WC) duplex. Two...DATES COVERED (From - To) 4. TITLE AND SUBTITLE FREE ENERGY GAP AND STATISTICAL THERMODYNAMIC FIDELITY OF DNA CODES 5a. CONTRACT NUMBER FA8750-07

  1. Sparse feature fidelity for perceptual image quality assessment.

    PubMed

    Chang, Hua-Wen; Yang, Hua; Gan, Yong; Wang, Ming-Hui

    2013-10-01

    The prediction of an image quality metric (IQM) should be consistent with subjective human evaluation. As the human visual system (HVS) is critical to visual perception, modeling of the HVS is regarded as the most suitable way to achieve perceptual quality predictions. Sparse coding that is equivalent to independent component analysis (ICA) can provide a very good description of the receptive fields of simple cells in the primary visual cortex, which is the most important part of the HVS. With this inspiration, a quality metric called sparse feature fidelity (SFF) is proposed for full-reference image quality assessment (IQA) on the basis of transformation of images into sparse representations in the primary visual cortex. The proposed method is based on the sparse features that are acquired by a feature detector, which is trained on samples of natural images by an ICA algorithm. In addition, two strategies are designed to simulate the properties of the visual perception: 1) visual attention and 2) visual threshold. The computation of SFF has two stages: training and fidelity computation, in addition, the fidelity computation consists of two components: feature similarity and luminance correlation. The feature similarity measures the structure differences between the two images, whereas the luminance correlation evaluates brightness distortions. SFF also reflects the chromatic properties of the HVS, and it is very effective for color IQA. The experimental results on five image databases show that SFF has a better performance in matching subjective ratings compared with the leading IQMs.

  2. High-fidelity gates in quantum dot spin qubits

    PubMed Central

    Koh, Teck Seng; Coppersmith, S. N.; Friesen, Mark

    2013-01-01

    Several logical qubits and quantum gates have been proposed for semiconductor quantum dots controlled by voltages applied to top gates. The different schemes can be difficult to compare meaningfully. Here we develop a theoretical framework to evaluate disparate qubit-gating schemes on an equal footing. We apply the procedure to two types of double-dot qubits: the singlet–triplet and the semiconducting quantum dot hybrid qubit. We investigate three quantum gates that flip the qubit state: a DC pulsed gate, an AC gate based on logical qubit resonance, and a gate-like process known as stimulated Raman adiabatic passage. These gates are all mediated by an exchange interaction that is controlled experimentally using the interdot tunnel coupling g and the detuning ϵ, which sets the energy difference between the dots. Our procedure has two steps. First, we optimize the gate fidelity (f) for fixed g as a function of the other control parameters; this yields an that is universal for different types of gates. Next, we identify physical constraints on the control parameters; this yields an upper bound that is specific to the qubit-gate combination. We show that similar gate fidelities should be attainable for singlet-triplet qubits in isotopically purified Si, and for hybrid qubits in natural Si. Considerably lower fidelities are obtained for GaAs devices, due to the fluctuating magnetic fields ΔB produced by nuclear spins. PMID:24255105

  3. The Assessment, Monitoring, and Enhancement of Treatment Fidelity In Public Health Clinical Trials

    PubMed Central

    Borrelli, Belinda

    2011-01-01

    Objectives To discuss methods of preservation of treatment fidelity in health behavior change trials conducted in public health contexts. Methods The treatment fidelity framework provided by the NIH’s Behavioral Change Consortium (BCC) (1) includes five domains of treatment fidelity (Study Design, Training, Delivery, Receipt, and Enactment). A measure of treatment fidelity was previously developed and validated using these categories. Results Strategies for assessment, monitoring, and enhancing treatment fidelity within each of the five treatment fidelity domains are discussed. The previously created measure of treatment fidelity is updated to include additional items on selecting providers, additional confounders, theory testing, and multicultural considerations. Conclusions Implementation of a treatment fidelity plan may require extra staff time and costs. However, the economic and scientific costs of lack of attention to treatment fidelity are far greater than the costs of treatment fidelity implementation. Maintaining high levels of treatment fidelity with flexible adaptation according to setting, provider, and patient is the goal for public health trials. PMID:21499543

  4. Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.

    PubMed

    Azpurua, Jorge; Ke, Zhonghe; Chen, Iris X; Zhang, Quanwei; Ermolenko, Dmitri N; Zhang, Zhengdong D; Gorbunova, Vera; Seluanov, Andrei

    2013-10-22

    The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments of unequal size. The two breakpoints are located in the 28S rRNA divergent region 6 and excise a fragment of 263 nt. The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other genomic regions. Because this hidden break site could alter ribosome structure, we investigated whether translation rate and amino acid incorporation fidelity were altered. We report that naked mole-rat fibroblasts have significantly increased translational fidelity despite having comparable translation rates with mouse fibroblasts. Although we cannot directly test whether the unique 28S rRNA structure contributes to the increased fidelity of translation, we speculate that it may change the folding or dynamics of the large ribosomal subunit, altering the rate of GTP hydrolysis and/or interaction of the large subunit with tRNA during accommodation, thus affecting the fidelity of protein synthesis. In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, supporting the hypothesis that the more stable proteome of the naked mole-rat contributes to its longevity.

  5. The effects of teacher fidelity of implementation of pathways to health on student outcomes.

    PubMed

    Little, Melissa A; Riggs, Nathaniel R; Shin, Hee-Sung; Tate, Eleanor B; Pentz, Mary Ann

    2015-03-01

    Previous research has demonstrated the importance of ensuring that programs are implemented as intended by program developers in order to achieve desired program effects. The current study examined implementation fidelity of Pathways to Health (Pathways), a newly developed obesity prevention program for fourth- through sixth-grade children. We explored the associations between self-reported and observed implementation fidelity scores and whether implementation fidelity differed across the first 2 years of program implementation. Additionally, we examined whether implementation fidelity affected program outcomes and whether teacher beliefs were associated with implementation fidelity. The program was better received, and implementation fidelity had more effects on program outcomes in fifth grade than in fourth grade. Findings suggest that implementation in school-based obesity programs may affect junk food intake and intentions to eat healthfully and exercise. School support was associated with implementation fidelity, suggesting that prevention programs may benefit from including a component that boosts school-wide support.

  6. Multi-fidelity wake modelling based on Co-Kriging method

    NASA Astrophysics Data System (ADS)

    Wang, Y. M.; Réthoré, P.-E.; van der Laan, M. P.; Murcia Leon, J. P.; Liu, Y. Q.; Li, L.

    2016-09-01

    The article presents an approach to combine wake models of multiple levels of fidelity, which is capable of giving accurate predictions with only a small number of high fidelity samples. The G. C. Larsen and k-ε-fP based RANS models are adopted as ensemble members of low fidelity and high fidelity models, respectively. Both the univariate and multivariate based surrogate models are established by taking the local wind speed and wind direction as variables of the wind farm power efficiency function. Various multi-fidelity surrogate models are compared and different sampling schemes are discussed. The analysis shows that the multi-fidelity wake models could tremendously reduce the high fidelity model evaluations needed in building an accurate surrogate.

  7. Coupled Solid Rocket Motor Ballistics and Trajectory Modeling for Higher Fidelity Launch Vehicle Design

    NASA Technical Reports Server (NTRS)

    Ables, Brett

    2014-01-01

    Multi-stage launch vehicles with solid rocket motors (SRMs) face design optimization challenges, especially when the mission scope changes frequently. Significant performance benefits can be realized if the solid rocket motors are optimized to the changing requirements. While SRMs represent a fixed performance at launch, rapid design iterations enable flexibility at design time, yielding significant performance gains. The streamlining and integration of SRM design and analysis can be achieved with improved analysis tools. While powerful and versatile, the Solid Performance Program (SPP) is not conducive to rapid design iteration. Performing a design iteration with SPP and a trajectory solver is a labor intensive process. To enable a better workflow, SPP, the Program to Optimize Simulated Trajectories (POST), and the interfaces between them have been improved and automated, and a graphical user interface (GUI) has been developed. The GUI enables real-time visual feedback of grain and nozzle design inputs, enforces parameter dependencies, removes redundancies, and simplifies manipulation of SPP and POST's numerous options. Automating the analysis also simplifies batch analyses and trade studies. Finally, the GUI provides post-processing, visualization, and comparison of results. Wrapping legacy high-fidelity analysis codes with modern software provides the improved interface necessary to enable rapid coupled SRM ballistics and vehicle trajectory analysis. Low cost trade studies demonstrate the sensitivities of flight performance metrics to propulsion characteristics. Incorporating high fidelity analysis from SPP into vehicle design reduces performance margins and improves reliability. By flying an SRM designed with the same assumptions as the rest of the vehicle, accurate comparisons can be made between competing architectures. In summary, this flexible workflow is a critical component to designing a versatile launch vehicle model that can accommodate a volatile

  8. Foot-and-mouth disease virus low-fidelity polymerase mutants are attenuated.

    PubMed

    Xie, Xiaochun; Wang, Haiwei; Zeng, Jianxiong; Li, Chen; Zhou, Guohui; Yang, Decheng; Yu, Li

    2014-10-01

    Previous studies have shown that RNA viruses can be attenuated by either increased or decreased viral polymerase replication fidelity. Although foot-and-mouth disease virus (FMDV) high-fidelity RNA-dependent RNA polymerase (RdRp) variants with an attenuated phenotype have been isolated using mutagens, no FMDV mutant with a low-fidelity polymerase has been documented to date. Here, we describe the generation of several FMDV RdRp mutants using site-directed mutagenesis via a reverse genetic system. Mutation frequency assays confirmed that five rescued FMDV RdRp mutant populations had lower replication fidelity than the wild-type virus population, which allowed us to assess the effects of the change in replication fidelity on the virus phenotype. These low-fidelity FMDV RdRp mutants showed increased sensitivity to ribavirin or 5-fluorouracil (5-FU) treatment without a loss of growth capacity in cell cultures. In addition, decreased fitness and attenuated virulence were observed for the RdRp mutants with lower fidelity. Importantly, based on a quantitative analysis for fidelity and virulence, we concluded that lower replication fidelity is associated with a more attenuated virus phenotype. These results further contribute to our understanding of the replication fidelity of polymerases of RNA viruses and its relationship to virulence attenuation.

  9. High Fidelity of Base Paring by 2-Selenothymidine in DNA

    SciTech Connect

    Hassan, A.; Sheng, J; Zhang, W; Huang, Z

    2010-01-01

    The base pairs are the contributors to the sequence-dependent recognition of nucleic acids, genetic information storage, and high fidelity of DNA polymerase replication. However, the wobble base pairing, where T pairs with G instead of A, reduces specific base-pairing recognition and compromises the high fidelity of the enzymatic polymerization. Via the selenium atomic probing at the 2-position of thymidine, we have investigated the wobble discrimination by manipulating the steric and electronic effects at the 2-exo position, providing a unique chemical strategy to enhance the base pair specificity. We report here the first synthesis of the novel 2-Se-thymidine ({sup Se}T) derivative, its phosphoramidite, and the Se-DNAs. Our biophysical and structural studies of the 2-Se-T DNAs reveal that the bulky 2-Se atom with a weak hydrogen-bonding ability can largely increase mismatch discriminations (including T/G wobble and T/C mismatched base pairs) while maintaining the {sup Se}T/A virtually identical to the native T/A base pair. The 2-Se atom bulkiness and the electronic effect are probably the main factors responsible for the discrimination against the formation of the wobble {sup Se}T/G base pair. Our investigations provide a potential novel tool to investigate the specific recognition of base pairs, which is the basis of high fidelity during replication, transcription, and translation. Furthermore, this Se-atom-specific substitution and probing are useful for X-ray crystal structure and function studies of nucleic acids.

  10. High fidelity of base pairing by 2-selenothymidine in DNA.

    PubMed

    Hassan, Abdalla E A; Sheng, Jia; Zhang, Wen; Huang, Zhen

    2010-02-24

    The base pairs are the contributors to the sequence-dependent recognition of nucleic acids, genetic information storage, and high fidelity of DNA polymerase replication. However, the wobble base pairing, where T pairs with G instead of A, reduces specific base-pairing recognition and compromises the high fidelity of the enzymatic polymerization. Via the selenium atomic probing at the 2-position of thymidine, we have investigated the wobble discrimination by manipulating the steric and electronic effects at the 2-exo position, providing a unique chemical strategy to enhance the base pair specificity. We report here the first synthesis of the novel 2-Se-thymidine ((Se)T) derivative, its phosphoramidite, and the Se-DNAs. Our biophysical and structural studies of the 2-Se-T DNAs reveal that the bulky 2-Se atom with a weak hydrogen-bonding ability can largely increase mismatch discriminations (including T/G wobble and T/C mismatched base pairs) while maintaining the (Se)T/A virtually identical to the native T/A base pair. The 2-Se atom bulkiness and the electronic effect are probably the main factors responsible for the discrimination against the formation of the wobble (Se)T/G base pair. Our investigations provide a potential novel tool to investigate the specific recognition of base pairs, which is the basis of high fidelity during replication, transcription, and translation. Furthermore, this Se-atom-specific substitution and probing are useful for X-ray crystal structure and function studies of nucleic acids.

  11. High fidelity wireless network evaluation for heterogeneous cognitive radio networks

    NASA Astrophysics Data System (ADS)

    Ding, Lei; Sagduyu, Yalin; Yackoski, Justin; Azimi-Sadjadi, Babak; Li, Jason; Levy, Renato; Melodia, Tammaso

    2012-06-01

    We present a high fidelity cognitive radio (CR) network emulation platform for wireless system tests, measure- ments, and validation. This versatile platform provides the configurable functionalities to control and repeat realistic physical channel effects in integrated space, air, and ground networks. We combine the advantages of scalable simulation environment with reliable hardware performance for high fidelity and repeatable evaluation of heterogeneous CR networks. This approach extends CR design only at device (software-defined-radio) or lower-level protocol (dynamic spectrum access) level to end-to-end cognitive networking, and facilitates low-cost deployment, development, and experimentation of new wireless network protocols and applications on frequency- agile programmable radios. Going beyond the channel emulator paradigm for point-to-point communications, we can support simultaneous transmissions by network-level emulation that allows realistic physical-layer inter- actions between diverse user classes, including secondary users, primary users, and adversarial jammers in CR networks. In particular, we can replay field tests in a lab environment with real radios perceiving and learning the dynamic environment thereby adapting for end-to-end goals over distributed spectrum coordination channels that replace the common control channel as a single point of failure. CR networks offer several dimensions of tunable actions including channel, power, rate, and route selection. The proposed network evaluation platform is fully programmable and can reliably evaluate the necessary cross-layer design solutions with configurable op- timization space by leveraging the hardware experiments to represent the realistic effects of physical channel, topology, mobility, and jamming on spectrum agility, situational awareness, and network resiliency. We also provide the flexibility to scale up the test environment by introducing virtual radios and establishing seamless signal

  12. High-fidelity replication of Dammann gratings using soft lithography.

    PubMed

    Wang, Wei; Zhou, Changhe; Jia, Wei

    2008-04-01

    We report the experimental results of using the soft lithography method for replication of Dammann gratings. By using an elastomeric stamp, uniform grating structures were transferred to the UV-curable polymer. To evaluate the quality of the replication, diffraction images and light intensity were measured. Compared with the master devices, the replicas of Dammann gratings show a slight deviation in both surface relief profile and optical performance. Experimental results demonstrated that high-fidelity replication of Dammann gratings is realized by using soft lithography with low cost and high throughput.

  13. Demonstration of deterministic and high fidelity squeezing of quantum information

    SciTech Connect

    Yoshikawa, Jun-ichi; Takei, Nobuyuki; Furusawa, Akira; Hayashi, Toshiki; Akiyama, Takayuki; Huck, Alexander; Andersen, Ulrik L.

    2007-12-15

    By employing a recent proposal [R. Filip, P. Marek, and U.L. Andersen, Phys. Rev. A 71, 042308 (2005)] we experimentally demonstrate a universal, deterministic, and high-fidelity squeezing transformation of an optical field. It relies only on linear optics, homodyne detection, feedforward, and an ancillary squeezed vacuum state, thus direct interaction between a strong pump and the quantum state is circumvented. We demonstrate three different squeezing levels for a coherent state input. This scheme is highly suitable for the fault-tolerant squeezing transformation in a continuous variable quantum computer.

  14. Replicating an intervention: the tension between fidelity and adaptation.

    PubMed

    Morrison, Diane M; Hoppe, Marilyn J; Gillmore, Mary Rogers; Kluver, Carisa; Higa, Darrel; Wells, Elizabeth A

    2009-04-01

    Increased awareness of the importance of tailoring interventions to participants' cultures has focused attention on the limited generalizability of a single test of an intervention to determine efficacy. Adaptation is often necessary to replicate interventions across cultures. This produces a tension between fidelity to the original intervention and adaptations necessary to make the intervention relevant to the culture and circumstances of participants. This article discusses issues that arise during the course of replication, with illustrations from a replication to test the efficacy of an HIV prevention intervention for youth, using a randomized controlled design. Analysis of the issues raised leads us to suggest that a "science of replication" needs to be developed.

  15. High-Fidelity Multidisciplinary Design Using an Integrated Design Environment

    DTIC Science & Technology

    2007-08-14

    Sc. PROGRAM ELEMENT NUMBER 6 . AUTHOR(S) Sd. PROJECT NUMBER Antony Jameson 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND...8217v Amial ’ysis and Optimization Conference, AIAA Paper 2(00 1- 1165, Albany., NY. A ugust. 3(1-Septemiber 1. 20011. 6 . J1. Alonso. P. L(’Gresloev, E...Cuomputatijonal Fluid Dynamics Conference, Toronto, Ontario. Canada, .Juno ( 6 -9. 20)05. 17. S. Choi, J1. Alonso and 1. Kroo, "Multi-Fidelity Design Optimization

  16. Bearings Incorporating Deadband Rollers

    NASA Technical Reports Server (NTRS)

    Gualtieri, Guy V.

    1996-01-01

    Bearings in high-pressure turbopump redesigned to incorporate rollers allowing limited axial motion within small deadband. Does not permit radial deadband motion. Axial deadband motion used for rotor-thrust-balance control. Design eliminates some nonlinearities in dynamics of pump rotor and assists in suppressing vibrations at harmonics of frequency of rotation.

  17. Using data to improve fidelity when implementing evidence-based programs.

    PubMed

    Kershner, Sarah; Flynn, Shannon; Prince, Mary; Potter, Susan C; Craft, Lesley; Alton, Forrest

    2014-03-01

    In fall 2011, the South Carolina Campaign to Prevent Teen Pregnancy (SC Campaign), with funding from Office of Adolescent Health, began replicating an evidence-based curriculum, It's Your Game, Keep It Real in 12 middle schools across South Carolina. Fidelity of the curriculum was monitored by the use of lesson fidelity logs completed by curriculum facilitators and lesson observation logs submitted by independent classroom observers. These data were monitored weekly to identify possible threats to fidelity. The innovative model Fidelity Through Informed Technical Assistance and Training was developed by SC Campaign to react to possible fidelity threats in real time, through a variety of technical assistance modalities. Fidelity Through Informed Technical Assistance and Training guided the 55 hours of technical assistance delivered by the SC Campaign during the first year of It's Your Game, Keep It Real implementation to 18 facilitators across 12 SC middle schools, and achieved 98.4% curriculum adherence and a high quality of implementation scores.

  18. Image gathering and digital restoration for fidelity and visual quality

    NASA Technical Reports Server (NTRS)

    Huck, Friedrich O.; Alter-Gartenberg, Rachel; Rahman, Zia-Ur

    1991-01-01

    The fidelity and resolution of the traditional Wiener restorations given in the prevalent digital processing literature can be significantly improved when the transformations between the continuous and discrete representations in image gathering and display are accounted for. However, the visual quality of these improved restorations also is more sensitive to the defects caused by aliasing artifacts, colored noise, and ringing near sharp edges. In this paper, these visual defects are characterized, and methods for suppressing them are presented. It is demonstrated how the visual quality of fidelity-maximized images can be improved when (1) the image-gathering system is specifically designed to enhance the performance of the image-restoration algorithm, and (2) the Wiener filter is combined with interactive Gaussian smoothing, synthetic high edge enhancement, and nonlinear tone-scale transformation. The nonlinear transformation is used primarily to enhance the spatial details that are often obscurred when the normally wide dynamic range of natural radiance fields is compressed into the relatively narrow dynamic range of film and other displays.

  19. Geographical variation in mutualistic networks: similarity, turnover and partner fidelity

    PubMed Central

    Trøjelsgaard, Kristian; Jordano, Pedro; Carstensen, Daniel W.; Olesen, Jens M.

    2015-01-01

    Although species and their interactions in unison represent biodiversity and all the ecological and evolutionary processes associated with life, biotic interactions have, contrary to species, rarely been integrated into the concepts of spatial β-diversity. Here, we examine β-diversity of ecological networks by using pollination networks sampled across the Canary Islands. We show that adjacent and distant communities are more and less similar, respectively, in their composition of plants, pollinators and interactions than expected from random distributions. We further show that replacement of species is the major driver of interaction turnover and that this contribution increases with distance. Finally, we quantify that species-specific partner compositions (here called partner fidelity) deviate from random partner use, but vary as a result of ecological and geographical variables. In particular, breakdown of partner fidelity was facilitated by increasing geographical distance, changing abundances and changing linkage levels, but was not related to the geographical distribution of the species. This highlights the importance of space when comparing communities of interacting species and may stimulate a rethinking of the spatial interpretation of interaction networks. Moreover, geographical interaction dynamics and its causes are important in our efforts to anticipate effects of large-scale changes, such as anthropogenic disturbances. PMID:25632001

  20. Total fidelity management in self-aligned multiple patterning process

    NASA Astrophysics Data System (ADS)

    Yamato, Masatoshi; Okabe, Noriaki; Hara, Arisa; Natori, Sakurako; Yamauchi, Shouhei; Koike, Kyohei; Oyama, Kenichi; Yaegashi, Hidetami

    2015-03-01

    Through the continuous scaling with extension of 193-immersion lithography, the multi-patterning process with the grid-based design has become nominal process for fine fabrication to relax tight pitch designs[1]. In self-aligned type multiple patterning, 7 nm node gate pattern was reported[2],[3] and it was become a focal point LER on core-pattern is essential category to control pattern placement variations. Though CD uniformity (CDU) on line pattern in self-aligned double patterning (SADP) is relatively stable caused in high thickness controllability of spacer deposition films, the variations of CDU and LER on first core pattern impinge the CDU on space and pitch pattern. In previous study, pattern fidelity of single exposure patterning was improved through photoresist smoothing process using direct-current superposition technique[4],[5]. In this paper, we will report that photoresist smoothing work in an efficient way to pattern fidelity control in self-aligned type multiple patterning.

  1. Patterns of communication in high-fidelity simulation.

    PubMed

    Anderson, Judy K; Nelson, Kimberly

    2015-01-01

    High-fidelity simulation is commonplace in nursing education. However, critical thinking, decision making, and psychomotor skills scenarios are emphasized. Scenarios involving communication occur in interprofessional or intraprofessional settings. The importance of effective nurse-patient communication is reflected in statements from the American Nurses Association and Quality and Safety Education for Nurses, and in the graduate outcomes of most nursing programs. This qualitative study examined the patterns of communication observed in video recordings of a medical-surgical scenario with 71 senior students in a baccalaureate program. Thematic analysis revealed patterns of (a) focusing on tasks, (b) communicating-in-action, and (c) being therapeutic. Additional categories under the patterns included missing opportunities, viewing the "small picture," relying on informing, speaking in "medical tongues," offering choices…okay?, feeling uncomfortable, and using therapeutic techniques. The findings suggest the importance of using high-fidelity simulation to develop expertise in communication. In addition, the findings reinforce the recommendation to prioritize communication aspects of scenarios and debriefing for all simulations.

  2. High Fidelity Simulation of Primary Atomization in Diesel Engine Sprays

    NASA Astrophysics Data System (ADS)

    Ivey, Christopher; Bravo, Luis; Kim, Dokyun

    2014-11-01

    A high-fidelity numerical simulation of jet breakup and spray formation from a complex diesel fuel injector at ambient conditions has been performed. A full understanding of the primary atomization process in fuel injection of diesel has not been achieved for several reasons including the difficulties accessing the optically dense region. Due to the recent advances in numerical methods and computing resources, high fidelity simulations of atomizing flows are becoming available to provide new insights of the process. In the present study, an unstructured un-split Volume-of-Fluid (VoF) method coupled to a stochastic Lagrangian spray model is employed to simulate the atomization process. A common rail fuel injector is simulated by using a nozzle geometry available through the Engine Combustion Network. The working conditions correspond to a single orifice (90 μm) JP-8 fueled injector operating at an injection pressure of 90 bar, ambient condition at 29 bar, 300 K filled with 100% nitrogen with Rel = 16,071, Wel = 75,334 setting the spray in the full atomization mode. The experimental dataset from Army Research Lab is used for validation in terms of spray global parameters and local droplet distributions. The quantitative comparison will be presented and discussed. Supported by Oak Ridge Associated Universities and the Army Research Laboratory.

  3. Metric and classical fidelity uncertainty relations for random unitary matrices

    NASA Astrophysics Data System (ADS)

    Adamczak, Radosław

    2017-03-01

    We analyze uncertainty relations on finite dimensional Hilbert spaces expressed in terms of classical fidelity, which are stronger than metric uncertainty relations introduced by Fawzi, Hayden and Sen. We establish the validity of fidelity uncertainty relations for random unitary matrices with optimal parameters (up to universal constants) which improves upon known results for the weaker notion of metric uncertainty. This result is then applied to locking classical information in quantum states and allows to obtain optimal locking in Hellinger distance, improving upon previous results on locking in the total variation distance, both by strengthening the metric used and by improving the dependence on parameters. We also show that general probabilistic estimates behind the main theorem can be used to prove existence of data hiding schemes with Bayesian type guarantees. As a byproduct of our approach we obtain existence of almost Euclidean subspaces of the matrix spaces \\ell 1n≤ft(\\ell 2m\\right) with a better dimension/distortion dependence than allowed in previously known constructions.

  4. Generalized Hofmann quantum process fidelity bounds for quantum filters

    NASA Astrophysics Data System (ADS)

    Sedlák, Michal; Fiurášek, Jaromír

    2016-04-01

    We propose and investigate bounds on the quantum process fidelity of quantum filters, i.e., probabilistic quantum operations represented by a single Kraus operator K . These bounds generalize the Hofmann bounds on the quantum process fidelity of unitary operations [H. F. Hofmann, Phys. Rev. Lett. 94, 160504 (2005), 10.1103/PhysRevLett.94.160504] and are based on probing the quantum filter with pure states forming two mutually unbiased bases. Determination of these bounds therefore requires far fewer measurements than full quantum process tomography. We find that it is particularly suitable to construct one of the probe bases from the right eigenstates of K , because in this case the bounds are tight in the sense that if the actual filter coincides with the ideal one, then both the lower and the upper bounds are equal to 1. We theoretically investigate the application of these bounds to a two-qubit optical quantum filter formed by the interference of two photons on a partially polarizing beam splitter. For an experimentally convenient choice of factorized input states and measurements we study the tightness of the bounds. We show that more stringent bounds can be obtained by more sophisticated processing of the data using convex optimization and we compare our methods for different choices of the input probe states.

  5. High-fidelity geometric modeling for biomedical applications

    SciTech Connect

    Yu, Zeyun; Holst, Michael J.; Andrew McCammon, J.

    2008-05-19

    In this paper, we describe a combination of algorithms for high-fidelity geometric modeling and mesh generation. Although our methods and implementations are application-neutral, our primary target application is multiscale biomedical models that range in scales across the molecular, cellular, and organ levels. Our software toolchain implementing these algorithms is general in the sense that it can take as input a molecule in PDB/PQR forms, a 3D scalar volume, or a user-defined triangular surface mesh that may have very low quality. The main goal of our work presented is to generate high quality and smooth surface triangulations from the aforementioned inputs, and to reduce the mesh sizes by mesh coarsening. Tetrahedral meshes are also generated for finite element analysis in biomedical applications. Experiments on a number of bio-structures are demonstrated, showing that our approach possesses several desirable properties: feature-preservation, local adaptivity, high quality, and smoothness (for surface meshes). Finally, the availability of this software toolchain will give researchers in computational biomedicine and other modeling areas access to higher-fidelity geometric models.

  6. Geographical variation in mutualistic networks: similarity, turnover and partner fidelity.

    PubMed

    Trøjelsgaard, Kristian; Jordano, Pedro; Carstensen, Daniel W; Olesen, Jens M

    2015-03-07

    Although species and their interactions in unison represent biodiversity and all the ecological and evolutionary processes associated with life, biotic interactions have, contrary to species, rarely been integrated into the concepts of spatial β-diversity. Here, we examine β-diversity of ecological networks by using pollination networks sampled across the Canary Islands. We show that adjacent and distant communities are more and less similar, respectively, in their composition of plants, pollinators and interactions than expected from random distributions. We further show that replacement of species is the major driver of interaction turnover and that this contribution increases with distance. Finally, we quantify that species-specific partner compositions (here called partner fidelity) deviate from random partner use, but vary as a result of ecological and geographical variables. In particular, breakdown of partner fidelity was facilitated by increasing geographical distance, changing abundances and changing linkage levels, but was not related to the geographical distribution of the species. This highlights the importance of space when comparing communities of interacting species and may stimulate a rethinking of the spatial interpretation of interaction networks. Moreover, geographical interaction dynamics and its causes are important in our efforts to anticipate effects of large-scale changes, such as anthropogenic disturbances.

  7. Designing Struts for the Low-Fidelity Orion Cockpit Mockup

    NASA Technical Reports Server (NTRS)

    Lucienne, Runa A.

    2009-01-01

    The objective of the project was to design and construct nine struts to be installed in the low-fidelity Orion cockpit mockup (Rev F; located at NASA s Johnson Space Center in Houston, TX) as simplified representations of the existing flight designed struts designed by engineers at Lockheed Martin (the primary contractor of the Orion). The project design included: researching the existing flight designs, brainstorming design upgrades, developing three unrelated three-dimensional (3D) strut designs using Pro/Engineer Wildfire 3.0, choosing the best fit design, locating materials and their sources, implementing the chosen design, and making design modifications. The project resulted in making simple modifications to the existing struts used in the last Orion cockpit mockup. The project is relevant to NASA, because upgrades to the low-fidelity Orion cockpit mockup progresses NASA s goals of developing and testing a new spacecraft, conducting the spacecraft's first crewed mission by 2015, returning to the moon by 2020, and exploring Mars and other planets in the future.

  8. Enhancing clinical practice and education with high-fidelity human patient simulators.

    PubMed

    Peteani, Leigh Ann

    2004-01-01

    Research shows that students exhibit increased autonomy and self-confidence when delivering patient care after practicing first with high-fidelity human patient simulators (HPS). Practicing clinical skills on a high-fidelity HPS allows students to learn in a highly adaptable, safe educational environment that fosters autonomy, independence, and the development of sound analytical skills. The author discusses the use of patient simulators in nursing education, a definition of a high-fidelity HPS, and their value to clinical practice and education. A cost-effective example of how to acquire a high-fidelity HPS without going over budget is provided.

  9. Quantum Monte Carlo simulations of fidelity at magnetic quantum phase transitions.

    PubMed

    Schwandt, David; Alet, Fabien; Capponi, Sylvain

    2009-10-23

    When a system undergoes a quantum phase transition, the ground-state wave function shows a change of nature, which can be monitored using the fidelity concept. We introduce two quantum Monte Carlo schemes that allow the computation of fidelity and its susceptibility for large interacting many-body systems. These methods are illustrated on a two-dimensional Heisenberg model, where fidelity estimators show marked behavior at two successive quantum phase transitions. We also develop a scaling theory which relates the divergence of the fidelity susceptibility to the critical exponent of the correlation length. A good agreement is found with the numerical results.

  10. Zinc Incorporation Into Hydroxylapatite

    SciTech Connect

    Tang, Y.; Chappell, H; Dove, M; Reeder, R; Lee, Y

    2009-01-01

    By theoretical modeling and X-ray absorption spectroscopy, the local coordination structure of Zn incorporated into hydroxylapatite was examined. Density function theory (DFT) calculations show that Zn favors the Ca2 site over the Ca1 site, and favors tetrahedral coordination. X-ray absorption near edge structure (XANES) spectroscopy results suggest one dominant coordination environment for the incorporated Zn, and no evidence was observed for other Zn-containing phases. Extended X-ray absorption fine structure (EXAFS) fitting of the synthetic samples confirms that Zn occurs in tetrahedral coordination, with two P shells at 2.85-3.07 {angstrom}, and two higher Ca shells at 3.71-4.02 {angstrom}. These fit results are consistent with the most favored DFT model for Zn substitution in the Ca2 site.

  11. Development of high-fidelity multiphysics system for light water reactor analysis

    NASA Astrophysics Data System (ADS)

    Magedanz, Jeffrey W.

    codes into a single executable, they are usually still developed and maintained separately. It should thus be a design objective to minimize the changes to those codes, and keep the changes to each code free of dependence on the details of the other codes. This will ease the incorporation of new versions of the code into the coupling, as well as re-use of parts of the coupling to couple with different codes. In order to fulfill this objective, an interface for each code was created in the form of an object-oriented abstract data type. Object-oriented programming is an effective method for enforcing a separation between different parts of a program, and clarifying the communication between them. The interfaces enable the main program to control the codes in terms of high-level functionality. This differs from the established practice of a master/slave relationship, in which the slave code is incorporated into the master code as a set of subroutines. While this PhD research continues previous work with a coupling between CTF and TORT-TD, it makes two major original contributions: (1) using a fuel-performance code, instead of a thermal-hydraulics code's simplified built-in models, to model the feedback from the fuel rods, and (2) the design of an object-oriented interface as an innovative method to interact with a coupled code in a high-level, easily-understandable manner. The resulting code system will serve as a tool to study the question of under what conditions, and to what extent, these higher-fidelity methods will provide benefits to reactor core analysis. (Abstract shortened by UMI.)

  12. An Immersed Boundary - Adaptive Mesh Refinement solver (IB-AMR) for high fidelity fully resolved wind turbine simulations

    NASA Astrophysics Data System (ADS)

    Angelidis, Dionysios; Sotiropoulos, Fotis

    2015-11-01

    The geometrical details of wind turbines determine the structure of the turbulence in the near and far wake and should be taken in account when performing high fidelity calculations. Multi-resolution simulations coupled with an immersed boundary method constitutes a powerful framework for high-fidelity calculations past wind farms located over complex terrains. We develop a 3D Immersed-Boundary Adaptive Mesh Refinement flow solver (IB-AMR) which enables turbine-resolving LES of wind turbines. The idea of using a hybrid staggered/non-staggered grid layout adopted in the Curvilinear Immersed Boundary Method (CURVIB) has been successfully incorporated on unstructured meshes and the fractional step method has been employed. The overall performance and robustness of the second order accurate, parallel, unstructured solver is evaluated by comparing the numerical simulations against conforming grid calculations and experimental measurements of laminar and turbulent flows over complex geometries. We also present turbine-resolving multi-scale LES considering all the details affecting the induced flow field; including the geometry of the tower, the nacelle and especially the rotor blades of a wind tunnel scale turbine. This material is based upon work supported by the Department of Energy under Award Number DE-EE0005482 and the Sandia National Laboratories.

  13. Use of High Fidelity Human Simulation to Teach Physical Therapist Decision-Making Skills for the Intensive Care Setting

    PubMed Central

    Riemersma, Lena; Perkins, Ron

    2009-01-01

    Introduction and Purpose: There is a paucity of discussion in the professional literature about the use of high fidelity human simulation (HFHS) as a teaching intervention in physical therapist educational programs. Therefore, the purpose of this paper is to provide an example of the design and use of high fidelity human simulation (HFHS) to facilitate teaching of cardiopulmonary and intensive care concepts in a physical therapist education program. Case Description: HFHS was used at the end of the fourth of 9 semesters in a Doctor of Physical Therapy program. An intensive care unit case scenario was developed that required students to perform procedural skills and apply biomedical knowledge/concepts to clinical decision-making during simulated patient mobilization. Outcomes: Students successfully completed the HFHS session objectives, though there was variability in how quickly they recognized and responded to alarms and changes in patient status. Psychomotor performance of skills was generally correct but awkward, consistent with novice performance. Students were universally positive about HFHS as a teaching strategy for preparing for an acute care clinical education experience. Discussion: One session using HFHS as a laboratory activity may have a substantial impact on students' perceptions and confidence prior to entering an acute care clinical experience. Physical therapist educational programs with access to HFHS resources should consider its incorporation into cardiopulmonary or acute care content. Given the high cost of acquiring and maintaining HFHS resources, programs without such resources should carefully consider the extent to which they would use HFHS in their curricula. PMID:20467529

  14. Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

    PubMed Central

    Crespan, Emmanuele; Furrer, Antonia; Rösinger, Marcel; Bertoletti, Federica; Mentegari, Elisa; Chiapparini, Giulia; Imhof, Ralph; Ziegler, Nathalie; Sturla, Shana J.; Hübscher, Ulrich; van Loon, Barbara; Maga, Giovanni

    2016-01-01

    Oxidative stress is a very frequent source of DNA damage. Many cellular DNA polymerases (Pols) can incorporate ribonucleotides (rNMPs) during DNA synthesis. However, whether oxidative stress-triggered DNA repair synthesis contributes to genomic rNMPs incorporation is so far not fully understood. Human specialized Pols β and λ are the important enzymes involved in the oxidative stress tolerance, acting both in base excision repair and in translesion synthesis past the very frequent oxidative lesion 7,8-dihydro-8-oxoguanine (8-oxo-G). We found that Pol β, to a greater extent than Pol λ can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases. Studies in Pol β- and λ-deficient cell extracts suggest that Pol β levels can greatly affect rNMP incorporation opposite oxidative DNA lesions. PMID:26917111

  15. Comparison of simulator fidelity model predictions with in-simulator evaluation data

    NASA Technical Reports Server (NTRS)

    Parrish, R. V.; Mckissick, B. T.; Ashworth, B. R.

    1983-01-01

    A full factorial in simulator experiment of a single axis, multiloop, compensatory pitch tracking task is described. The experiment was conducted to provide data to validate extensions to an analytic, closed loop model of a real time digital simulation facility. The results of the experiment encompassing various simulation fidelity factors, such as visual delay, digital integration algorithms, computer iteration rates, control loading bandwidths and proprioceptive cues, and g-seat kinesthetic cues, are compared with predictions obtained from the analytic model incorporating an optimal control model of the human pilot. The in-simulator results demonstrate more sensitivity to the g-seat and to the control loader conditions than were predicted by the model. However, the model predictions are generally upheld, although the predicted magnitudes of the states and of the error terms are sometimes off considerably. Of particular concern is the large sensitivity difference for one control loader condition, as well as the model/in-simulator mismatch in the magnitude of the plant states when the other states match.

  16. Novel high-fidelity realistic explosion damage simulation for urban environments

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoqing; Yadegar, Jacob; Zhu, Youding; Raju, Chaitanya; Bhagavathula, Jaya

    2010-04-01

    Realistic building damage simulation has a significant impact in modern modeling and simulation systems especially in diverse panoply of military and civil applications where these simulation systems are widely used for personnel training, critical mission planning, disaster management, etc. Realistic building damage simulation should incorporate accurate physics-based explosion models, rubble generation, rubble flyout, and interactions between flying rubble and their surrounding entities. However, none of the existing building damage simulation systems sufficiently faithfully realize the criteria of realism required for effective military applications. In this paper, we present a novel physics-based high-fidelity and runtime efficient explosion simulation system to realistically simulate destruction to buildings. In the proposed system, a family of novel blast models is applied to accurately and realistically simulate explosions based on static and/or dynamic detonation conditions. The system also takes account of rubble pile formation and applies a generic and scalable multi-component based object representation to describe scene entities and highly scalable agent-subsumption architecture and scheduler to schedule clusters of sequential and parallel events. The proposed system utilizes a highly efficient and scalable tetrahedral decomposition approach to realistically simulate rubble formation. Experimental results demonstrate that the proposed system has the capability to realistically simulate rubble generation, rubble flyout and their primary and secondary impacts on surrounding objects including buildings, constructions, vehicles and pedestrians in clusters of sequential and parallel damage events.

  17. Many places called home: the adaptive value of seasonal adjustments in range fidelity.

    PubMed

    Lafontaine, Alexandre; Drapeau, Pierre; Fortin, Daniel; St-Laurent, Martin-Hugues

    2017-02-01

    The vast majority of animal species display range fidelity, a space-use behaviour enhancing familiarity with local habitat features. While the fitness benefits of this behaviour have been demonstrated in a variety of taxa, some species or populations rather display infidelity, displacing their home range over time. Others, such as many ungulate species, show seasonal adjustments in their range fidelity to accommodate changes in the dominance of limiting factors or in the distribution of resources. Few empirical studies have explored the adaptive value of seasonal adjustments in range fidelity. Using boreal populations of woodland caribou (Rangifer tarandus caribou) as a biological model, we evaluated how range fidelity impacted individual performance during two seasons where juvenile and adult survival are limited by different predation pressures. Between 2004 and 2013, we monitored the survival, reproductive success, habitat selection and range fidelity of female caribou in the boreal forest of eastern Canada. Using resource selection functions, we assessed how seasonal range fidelity was linked to two fitness correlates: calf survival in summer and adult female survival in winter. Females displayed season-specific space use tactics: they selected previously used areas during calving and summer, but tended to shift their winter range from 1 year to the next. During calving and summer, range fidelity yielded relatively high fitness benefits, as females that did not lose their calf displayed stronger fidelity than females that did. In winter, however, adult survival was negatively linked to range fidelity, as females that survived selected areas further away from their seasonal range of the previous year than females that died. We provide one of the first evidences that making seasonal adjustments in range fidelity can be an adaptive behaviour influencing the spatial distribution of a threatened species. Assessing the seasonal nature of range fidelity tactics may

  18. A high-fidelity multiresolution digital elevation model for Earth systems

    NASA Astrophysics Data System (ADS)

    Duan, Xinqiao; Li, Lin; Zhu, Haihong; Ying, Shen

    2017-01-01

    The impact of topography on Earth systems variability is well recognised. As numerical simulations evolved to incorporate broader scales and finer processes, accurately assimilating or transforming the topography to produce more exact land-atmosphere-ocean interactions, has proven to be quite challenging. Numerical schemes of Earth systems often use empirical parameterisation at sub-grid scale with downscaling to express topographic endogenous processes, or rely on insecure point interpolation to induce topographic forcing, which creates bias and input uncertainties. Digital elevation model (DEM) generalisation provides more sophisticated systematic topographic transformation, but existing methods are often difficult to be incorporated because of unwarranted grid quality. Meanwhile, approaches over discrete sets often employ heuristic approximation, which are generally not best performed. Based on DEM generalisation, this article proposes a high-fidelity multiresolution DEM with guaranteed grid quality for Earth systems. The generalised DEM surface is initially approximated as a triangulated irregular network (TIN) via selected feature points and possible input features. The TIN surface is then optimised through an energy-minimised centroidal Voronoi tessellation (CVT). By devising a robust discrete curvature as density function and exact geometry clipping as energy reference, the developed curvature CVT (cCVT) converges, the generalised surface evolves to a further approximation to the original DEM surface, and the points with the dual triangles become spatially equalised with the curvature distribution, exhibiting a quasi-uniform high-quality and adaptive variable resolution. The cCVT model was then evaluated on real lidar-derived DEM datasets and compared to the classical heuristic model. The experimental results show that the cCVT multiresolution model outperforms classical heuristic DEM generalisations in terms of both surface approximation precision and

  19. Fidelity optimization for holonomic quantum gates in dissipative environments

    SciTech Connect

    Parodi, Daniele; Solinas, Paolo; Zanghi, Nino; Sassetti, Maura; Zanardi, Paolo

    2006-05-15

    We analyze the performance of holonomic quantum gates in semiconductor quantum dots, driven by ultrafast lasers, under the effect of a dissipative environment. The environment is modeled as a thermal bath of oscillators linearly coupled with the electron states of the quantum dot. Standard techniques make the problem amenable to a numerical treatment and allow one to determine the fidelity as a function of all the relevant physical parameters. As a consequence of our analysis, we show that the disturbance of the environment can be (approximately) suppressed and the performance of the gate optimized--provided that the thermal bath is purely super-Ohmic. We conclude by showing that such an optimization is impossible for Ohmic environments.

  20. Solvent-induced high fidelity switching between two discrete supramolecules.

    PubMed

    Betancourt, José E; Martín-Hidalgo, Mariana; Gubala, Vladimir; Rivera, José M

    2009-03-11

    Here we show the reversible high fidelity switching between two discrete self-assembled supramolecules made from a lipophilic 8-phenyl-2'-deoxyguanosine derivative induced by an indirect solvent effect. A hexadecameric supramolecule containing four stacked tetramers is formed in acetonitrile aided by higher potassium concentrations. When the amount of weakly solvated potassium decreases, due the lower activity of potassium iodide in chloroform, an octamer is formed after the dissociation of the two outer tetramers in the hexadecamer. The switching process results from an unprecedented subtle interplay between the activity of potassium iodide and the steric crowding within the self-assembled structure. Besides the possible applications in nanoconstruction, this phenomenon sheds light into the mechanism of formation of self-assembled supramolecules made from guanosine derivatives.

  1. Fidelity study of superconductivity in extended Hubbard models

    DOE PAGES

    Plonka, N.; Jia, C. J.; Wang, Y.; ...

    2015-07-08

    The Hubbard model with local on-site repulsion is generally thought to possess a superconducting ground state for appropriate parameters, but the effects of more realistic long-range Coulomb interactions have not been studied extensively. We study the influence of these interactions on superconductivity by including nearest- and next-nearest-neighbor extended Hubbard interactions in addition to the usual on-site terms. Utilizing numerical exact diagonalization, we analyze the signatures of superconductivity in the ground states through the fidelity metric of quantum information theory. Finally, we find that nearest and next-nearest neighbor interactions have thresholds above which they destabilize superconductivity regardless of whether they aremore » attractive or repulsive, seemingly due to competing charge fluctuations.« less

  2. [Low Fidelity Simulation of a Zero-Y Robot

    NASA Technical Reports Server (NTRS)

    Sweet, Adam

    2001-01-01

    The item to be cleared is a low-fidelity software simulation model of a hypothetical freeflying robot designed for use in zero gravity environments. This simulation model works with the HCC simulation system that was developed by Xerox PARC and NASA Ames Research Center. HCC has been previously cleared for distribution. When used with the HCC software, the model computes the location and orientation of the simulated robot over time. Failures (such as a broken motor) can be injected into the simulation to produce simulated behavior corresponding to the failure. Release of this simulation will allow researchers to test their software diagnosis systems by attempting to diagnose the simulated failure from the simulated behavior. This model does not contain any encryption software nor can it perform any control tasks that might be export controlled.

  3. Automating Initial Guess Generation for High Fidelity Trajectory Optimization Tools

    NASA Technical Reports Server (NTRS)

    Villa, Benjamin; Lantoine, Gregory; Sims, Jon; Whiffen, Gregory

    2013-01-01

    Many academic studies in spaceflight dynamics rely on simplified dynamical models, such as restricted three-body models or averaged forms of the equations of motion of an orbiter. In practice, the end result of these preliminary orbit studies needs to be transformed into more realistic models, in particular to generate good initial guesses for high-fidelity trajectory optimization tools like Mystic. This paper reviews and extends some of the approaches used in the literature to perform such a task, and explores the inherent trade-offs of such a transformation with a view toward automating it for the case of ballistic arcs. Sample test cases in the libration point regimes and small body orbiter transfers are presented.

  4. Noise effect on fidelity of two-qubit teleportation

    SciTech Connect

    Hu Xueyuan; Gu Ying; Gong Qihuang; Guo Guangcan

    2010-05-15

    We investigate the effect of noise on a class of four-qubit entangled channels for two-qubit teleportation from Alice to Bob. These entangled channels include both parallel Bell pairs and inseparable channels with genuine multipartite entanglement. For the situation where only Bob's share of the entangled channel is subject to decoherence, we show by deriving a general expression for the teleported state that teleportation using noisy inseparable channels is equivalent to teleportation using noisy Bell pairs. When Alice's qubits are also subject to noise, we find that the inseparable channels never give a higher teleportation fidelity than Bell pairs, even in the presence of collective noise. Our results can shed some light on practical two-qubit teleportation.

  5. Mixed-state fidelity susceptibility through iterated commutator series expansion.

    PubMed

    Tonchev, N S

    2014-11-01

    We present a perturbative approach to the problem of computation of mixed-state fidelity susceptibility (MFS) for thermal states. The mathematical techniques used provide an analytical expression for the MFS as a formal expansion in terms of the thermodynamic mean values of successively higher commutators of the Hamiltonian with the operator involved through the control parameter. That expression is naturally divided into two parts: the usual isothermal susceptibility and a constituent in the form of an infinite series of thermodynamic mean values which encodes the noncommutativity in the problem. If the symmetry properties of the Hamiltonian are given in terms of the generators of some (finite-dimensional) algebra, the obtained expansion may be evaluated in a closed form. This issue is tested on several popular models, for which it is shown that the calculations are much simpler if they are based on the properties from the representation theory of the Heisenberg or SU(1, 1) Lie algebra.

  6. Classical broadcasting is possible with arbitrarily high fidelity and resolution.

    PubMed

    Walker, Thomas A; Braunstein, Samuel L

    2007-02-23

    We quantify the resolution with which any probability distribution may be distinguished from a displaced copy of itself in terms of a characteristic width. This width, which we call the resolution, is well defined for any normalizable probability distribution. We use this concept to study the broadcasting of classical probability distributions. Ideal classical broadcasting creates two (or more) output random variables each of which has the same distribution as the input random variable. We show that the universal broadcasting of probability distributions may be achieved with arbitrarily high fidelities for any finite resolution. By restricting probability distributions to any finite resolution we have therefore shown that the classical limit of quantum broadcasting is consistent with the actual classical case.

  7. Evaluating Implementation Fidelity in Health Information Technology Interventions

    PubMed Central

    Eisenstein, Eric L.; Lobach, David F.; Montgomery, Paul; Kawamoto, Kensaku; Anstrom, Kevin J.

    2007-01-01

    Health information technology evaluators need to distinguish between intervention efficacy as assessed in the ideal circumstances of clinical trials and intervention effectiveness as assessed in the real world circumstances of actual practice. Because current evaluation study designs do not routinely allow for this distinction, we have developed a framework for evaluation of implementation fidelity that considers health information technologies as complex interventions and makes use of common intervention components as defined in the Oxford Implementation Index. We also propose statistical methods for the evaluation of interventions at the system and component level using the Rubin Causal Model. We then describe how to apply this framework to evaluate an ongoing clinical trial of three health information technology interventions currently implemented in a 17,000 patient community-based health network caring for Medicaid beneficiaries in Durham County, North Carolina. PMID:18693828

  8. Fidelity study of superconductivity in extended Hubbard models

    SciTech Connect

    Plonka, N.; Jia, C. J.; Wang, Y.; Moritz, B.; Devereaux, T. P.

    2015-07-08

    The Hubbard model with local on-site repulsion is generally thought to possess a superconducting ground state for appropriate parameters, but the effects of more realistic long-range Coulomb interactions have not been studied extensively. We study the influence of these interactions on superconductivity by including nearest- and next-nearest-neighbor extended Hubbard interactions in addition to the usual on-site terms. Utilizing numerical exact diagonalization, we analyze the signatures of superconductivity in the ground states through the fidelity metric of quantum information theory. Finally, we find that nearest and next-nearest neighbor interactions have thresholds above which they destabilize superconductivity regardless of whether they are attractive or repulsive, seemingly due to competing charge fluctuations.

  9. Hand ultrasound: a high-fidelity simulation of lung sliding.

    PubMed

    Shokoohi, Hamid; Boniface, Keith

    2012-09-01

    Simulation training has been effectively used to integrate didactic knowledge and technical skills in emergency and critical care medicine. In this article, we introduce a novel model of simulating lung ultrasound and the features of lung sliding and pneumothorax by performing a hand ultrasound. The simulation model involves scanning the palmar aspect of the hand to create normal lung sliding in varying modes of scanning and to mimic ultrasound features of pneumothorax, including "stratosphere/barcode sign" and "lung point." The simple, reproducible, and readily available simulation model we describe demonstrates a high-fidelity simulation surrogate that can be used to rapidly illustrate the signs of normal and abnormal lung sliding at the bedside.

  10. Mixed-state fidelity susceptibility through iterated commutator series expansion

    NASA Astrophysics Data System (ADS)

    Tonchev, N. S.

    2014-11-01

    We present a perturbative approach to the problem of computation of mixed-state fidelity susceptibility (MFS) for thermal states. The mathematical techniques used provide an analytical expression for the MFS as a formal expansion in terms of the thermodynamic mean values of successively higher commutators of the Hamiltonian with the operator involved through the control parameter. That expression is naturally divided into two parts: the usual isothermal susceptibility and a constituent in the form of an infinite series of thermodynamic mean values which encodes the noncommutativity in the problem. If the symmetry properties of the Hamiltonian are given in terms of the generators of some (finite-dimensional) algebra, the obtained expansion may be evaluated in a closed form. This issue is tested on several popular models, for which it is shown that the calculations are much simpler if they are based on the properties from the representation theory of the Heisenberg or SU(1, 1) Lie algebra.

  11. High-fidelity plasma codes for burn physics

    SciTech Connect

    Cooley, James; Graziani, Frank; Marinak, Marty; Murillo, Michael

    2016-10-19

    Accurate predictions of equation of state (EOS), ionic and electronic transport properties are of critical importance for high-energy-density plasma science. Transport coefficients inform radiation-hydrodynamic codes and impact diagnostic interpretation, which in turn impacts our understanding of the development of instabilities, the overall energy balance of burning plasmas, and the efficacy of self-heating from charged-particle stopping. Important processes include thermal and electrical conduction, electron-ion coupling, inter-diffusion, ion viscosity, and charged particle stopping. However, uncertainties in these coefficients are not well established. Fundamental plasma science codes, also called high-fidelity plasma codes, are a relatively recent computational tool that augments both experimental data and theoretical foundations of transport coefficients. This paper addresses the current status of HFPC codes and their future development, and the potential impact they play in improving the predictive capability of the multi-physics hydrodynamic codes used in HED design.

  12. Implementation science: issues of fidelity to consider in community nursing.

    PubMed

    Hanafin, Sinead; O'Reilly, Emma Dwan

    2015-09-01

    Programme implementation is a complex process, and literature around the area of implementation science is growing, particularly with respect to programme fidelity (Dusenbury et al, 2003; Carroll et al, 2007). This paper draws on the findings from an evaluation in one area involving restructuring of the Public Health Nursing service from a generalist, geographically based service, to a team-based specialist approach. From this evaluation, it is clear that careful consideration must be given to a number of key issues that could arise in moving from a pilot project to a more mainstream or widescale implementation. These issues could relate to workforce planning; the role of the team leader; formation, maintenance, and development of teams; expertise and knowledge, including knowledge of local communities; active caseload management; continuity across a range of areas; alignment with primary care teams; co-location; and the need for support, particularly in the IT infrastructure.

  13. High Fidelity Simulations of Unsteady Flow through Turbopumps and Flowliners

    NASA Technical Reports Server (NTRS)

    Kiris, Cetin C.; Kwak, dochan; Chan, William; Housman, Jeff

    2006-01-01

    High fidelity computations were carried out to analyze the orbiter LH2 feedline flowliner. Computations were performed on the Columbia platform which is a 10,240-processor supercluster consisting of 20 Altix nodes with 512 processor each. Various computational models were used to characterize the unsteady flow features in the turbopump, including the orbiter Low-Pressure-Fuel-Turbopump (LPFTP) inducer, the orbiter manifold and a test article used to represent the manifold. Unsteady flow originating from the orbiter LPFTP inducer is one of the major contributors to the high frequency cyclic loading that results in high cycle fatigue damage to the gimbal flowliners just upstream of the LPFTP. The flow fields for the orbiter manifold and representative test article are computed and analyzed for similarities and differences. The incompressible Navier-Stokes flow solver INS3D, based on the artificial compressibility method, was used to compute the flow of liquid hydrogen in each test article.

  14. Observational Requirements for High-Fidelity Reverberation Mapping

    NASA Technical Reports Server (NTRS)

    Horne, Keith; Peterson, Bradley M.; Collier, Stefan J.; Netzer, Hagai

    2004-01-01

    We present a series of simulations to demonstrate that high-fidelity velocity-delay maps of the emission-line regions in active galactic nuclei can be obtained from time-resolved spectrophotometric data sets like those that will arise from the proposed Kronos satellite. While previous reverberation-mapping experiments have established the size scale R of the broad emission-line regions from the mean time delay tau = R/c between the line and continuum variations and have provided strong evidence for supermassive black holes, the detailed structure and kinematics of the broad-line region remain ambiguous and poorly constrained. Here we outline the technical improvements that will be required to successfully map broad-line regions by reverberation techniques. For typical AGN continuum light curves, characterized by power-law power spectra P (f) is proportional to f(exp -alpha) with a = -1.5 +/- 0.5, our simulations show that a small UV/optical spectrometer like Kronos will clearly distinguish between currently viable alternative kinematic models. From spectra sampled at time intervals Delta t and sustained for a total duration T(sub dur), we can reconstruct high-fidelity velocity-delay maps with velocity resolution comparable to that of the spectra, and delay resolution Delta tau approx. 2 Delta t, provided T(sub dur) exceeds the broad-line region light crossing time by at least a factor of three. Even very complicated kinematical models, such as a Keplerian flow with superimposed spiral wave pattern, are resolved in maps from our simulated Kronos datasets. Reverberation mapping with Kronos data is therefore likely deliver the first clear maps of the geometry and kinematics in the broad emission-line regions 1-100 microarcseconds from supermassive black holes.

  15. Enhancing Therapeutic Gains: Examination of Fidelity to the Model for the Intensive Mental Health Program

    ERIC Educational Resources Information Center

    Randall, Camille J.; Biggs, Bridget K.

    2008-01-01

    Given that the development of treatment fidelity assessment protocol is an integral but too frequently ignored aspect of clinical trials for psychological treatments, the Intensive Mental Health Program (IMHP) sought to build fidelity activities into training, program evaluation, and clinical recordkeeping from the outset of a 3 year study period.…

  16. Assessing Implementation Fidelity: Challenges as Seen through the Lens of Two Experimental Studies

    ERIC Educational Resources Information Center

    Vig, Rozy; Taylor, Megan W.; Star, Jon R.; Chao, Theodore

    2014-01-01

    The concept of "implementation fidelity" is broadly used to capture the extent to which an intervention is executed as intended by the designers of the intervention (Century, Rudnick, & Freeman, 2010; Huntley, 2005, McNaught, Tarr, & Sears, 2010, Munter, 2010). Though implementation fidelity instruments are often used to assess…

  17. Physical Education Teachers Fidelity to and Perspectives of a Standardized Curricular Model

    ERIC Educational Resources Information Center

    Kloeppel, Tiffany; Stylianou, Michalis; Kulinna, Pamela Hodges

    2014-01-01

    Relatively little is known about the use of standardized physical education curricular models and teachers perceptions of and fidelity to such curricula. The purpose of this study was to examine teachers perceptions of and fidelity to a standardized physical education curricular model (i.e., Dynamic Physical Education [DPE]). Participants for this…

  18. Using Indices of Fidelity to Intervention Core Components to Identify Program Active Ingredients

    ERIC Educational Resources Information Center

    Abry, Tashia; Hulleman, Chris S.; Rimm-Kaufman, Sara E.

    2015-01-01

    Identifying the active ingredients of an intervention--intervention-specific components serving as key levers of change--is crucial for unpacking the intervention black box. Measures of intervention fidelity can be used to identify specific active ingredients, yet such applications are rare. We illustrate how fidelity measures can be used to…

  19. 75 FR 42749 - Fidelity National Financial, Inc.; Analysis of the Agreement Containing Consent Order to Aid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... the title insurance business, and has pre-existing relationships with entities and individuals in the.... (``Fidelity''). Fidelity purchased three title insurance subsidiaries from LandAmerica Financial, Inc. (``LandAmerica''). The subsidiaries were Commonwealth Land Title Insurance Company (``Commonwealth''),...

  20. Measuring Fidelity of Implementation--Methodological and Conceptual Issues and Challenges. CRESST Report 811

    ERIC Educational Resources Information Center

    Osmundson, Ellen; Herman, Joan; Ringstaff, Cathy; Dai, Yunyun; Timms, Mike

    2012-01-01

    A central challenge in efficacy studies centers on the issue of "fidelity of implementation," that is, the extent to which participants use the curriculum specified by curriculum developers. In this study, we describe and discuss a "fidelity of implementation" model using multiple methods and instruments to compare two versions of a science…

  1. Academic Fidelity and Integrity as Attributes of University Online Degree Program Offerings

    ERIC Educational Resources Information Center

    Gambescia, Stephen F.; Paolucci, Rocco

    2009-01-01

    As stakeholders continue to discuss, debate, and advocate their positions related to the value of online learning at colleges and universities, one element that will continue to be discussed, regardless of the specific issue at hand, is "academic integrity and fidelity". Academic fidelity of online degree program offerings is defined in this study…

  2. Establishing Treatment Fidelity in a Web-Based Behavioral Intervention Study

    PubMed Central

    Eaton, Linda H.; Doorenbos, Ardith Z.; Schmitz, KrisAnn L.; Carpenter, Kelly M.; McGregor, Bonnie A.

    2011-01-01

    Background Treatment fidelity pertains to the methodological strategies used to monitor and enhance the reliability and validity of behavioral interventions. Approaches to establishing treatment fidelity in Web-based interventions differ from those used in interventions that are delivered in person. Objective To describe a methodology for ensuring treatment fidelity in a Web-based cognitive behavioral stress management intervention. Methods The intervention Coping with Cancer Workbook, adapted for Web-based delivery from an in-person intervention, was tested in a randomized controlled trial with 123 breast cancer survivors. Strategies for ensuring treatment fidelity were implemented and assessed. Results The National Institutes of Health Behavior Change Consortium Treatment Fidelity Guidelines were relevant to establishing treatment fidelity for the Web-based intervention. Discussion Web-based delivery of behavioral interventions is both a strength and a threat to treatment fidelity. Investigators must be cognizant of the elements of treatment fidelity and implement strategies to monitor and improve the reliability and validity of Web-based interventions. PMID:22048559

  3. Treatment Fidelity in Social Work Intervention Research: A Review of Published Studies

    ERIC Educational Resources Information Center

    Naleppa, Matthias J.; Cagle, John G.

    2010-01-01

    Objectives: This study investigated treatment fidelity in social work research. Method: The authors systematically reviewed all articles published in five prominent social work journals over a 5- year period. Sixty-three outcome studies were identified and reviewed for how well treatment fidelity was monitored using eight review criteria. Results:…

  4. Sources of variation in breeding-ground fidelity of mallards (Anas platyrhynchos)

    USGS Publications Warehouse

    Doherty, P.F.; Nichols, J.D.; Tautin, J.; Voelzer, J.E.; Smith, G.W.; Benning, D.S.; Bentley, V.R.; Bidwell, J.K.; Bollinger, K.S.; Brazda, A.R.; Buelna, E.K.; Goldsberry, J.R.; King, R.J.; Roetker, F.H.; Solberg, J.W.; Thorpe, P.P.; Wortham, J.S.

    2002-01-01

    Generalizations used to support hypotheses about the evolution of fidelity to breeding areas in birds include the tendency for fidelity to be greater in adult birds than in yearlings. In ducks, in contrast to most bird species, fidelity is thought to be greater among females than males. Researchers have suggested that fidelity in ducks is positively correlated with pond availability. However, most estimates of fidelity on which these inferences have been based represent functions of survival and recapture-resighting probabilities in addition to fidelity. We applied the modeling approach developed by Burnham to recapture and band recovery data of mallard ducks to test the above hypotheses about fidelity. We found little evidence of sex differences in adult philopatry, with females being slightly more philopatric than males in one study area, but not in a second study area. However, yearling females were more philopatric than yearling males in both study areas. We found that adults were generally more philopatric than yearlings. We could find no relationship between fidelity and pond availability. Our results, while partially supporting current theory concerning sex and age differences in philopatry, suggest that adult male mallards are more philopatric than once thought, and we recommend that other generalizations about philopatry be revisited with proper estimation techniques.

  5. Computer-Based versus High-Fidelity Mannequin Simulation in Developing Clinical Judgment in Nursing Education

    ERIC Educational Resources Information Center

    Howard, Beverly J.

    2013-01-01

    The purpose of this study was to determine if students learn clinical judgment as effectively using computer-based simulations as when using high-fidelity mannequin simulations. There was a single research questions for this study: What is the difference in clinical judgment between participants completing high-fidelity human simulator mannequin…

  6. Implementation Fidelity in Adolescent Family-Based Prevention Programs: Relationship to Family Engagement

    ERIC Educational Resources Information Center

    Byrnes, Hilary F.; Miller, Brenda A.; Aalborg, Annette E.; Plasencia, Ana V.; Keagy, Carolyn D.

    2010-01-01

    Reliability and validity of intervention studies are impossible without adequate program fidelity, as it ensures that the intervention was implemented as designed and allows for accurate conclusions about effectiveness (Bellg AJ, Borrelli B, Resnick B "et al." Enhancing treatment fidelity in health behavior change studies: best practices…

  7. Blending Qualitative and Computational Linguistics Methods for Fidelity Assessment: Experience with the Familias Unidas Preventive Intervention

    PubMed Central

    Gallo, Carlos; Pantin, Hilda; Villamar, Juan; Prado, Guillermo; Tapia, Maria; Ogihara, Mitsunori; Cruden, Gracelyn; Brown, C Hendricks

    2014-01-01

    Careful fidelity monitoring and feedback are critical to implementing effective interventions. A wide range of procedures exist to assess fidelity; most are derived from observational assessments (Schoenwald et al, 2013). However, these fidelity measures are resource intensive for research teams in efficacy/effectiveness trials, and are often unattainable or unmanageable for the host organization to rate when the program is implemented on a large scale. We present a first step towards automated processing of linguistic patterns in fidelity monitoring of a behavioral intervention using an innovative mixed methods approach to fidelity assessment that uses rule-based, computational linguistics to overcome major resource burdens. Data come from an effectiveness trial of the Familias Unidas intervention, an evidence-based, family-centered preventive intervention found to be efficacious in reducing conduct problems, substance use and HIV sexual risk behaviors among Hispanic youth. This computational approach focuses on “joining,” which measures the quality of the working alliance of the facilitator with the family. Quantitative assessments of reliability are provided. Kappa scores between a human rater and a machine rater for the new method for measuring joining reached .83. Early findings suggest that this approach can reduce the high cost of fidelity measurement and the time delay between fidelity assessment and feedback to facilitators; it also has the potential for improving the quality of intervention fidelity ratings. PMID:24500022

  8. A Randomized-Controlled Trial of the Effects of Online Training on Implementation Fidelity

    ERIC Educational Resources Information Center

    Drake, Pamela M.; Firpo-Triplett, Regina; Glassman, Jill R.; Ong, Seow Ling; Unti, Lisa

    2015-01-01

    The effectiveness of evidence-based programs can be compromised if the program is not implemented with fidelity. This article describes the evaluation of an online training to improve implementation fidelity to an evidence-based HIV prevention curriculum, Reducing the Risk, through online skills-based instruction and support. Educators were…

  9. Validation of a Fidelity Rating Instrument for Consumer-Operated Services

    ERIC Educational Resources Information Center

    Mowbray, Carol T.; Bybee, Deborah; Holter, Mark; Lewandowski, Lisa

    2006-01-01

    With the emphasis on the use of evidence-based practices has come a need to measure the fidelity of replications to the operations and principles of original models. Recent reviews have focused on methods to develop fidelity measures for evidence-based program models. However, the issue of how to validate such measures has been given scant…

  10. Fidelity of Implementation in a Treatment Effectiveness Trial of Reconnecting Youth

    ERIC Educational Resources Information Center

    Sanchez, Victoria; Steckler, Allan; Nitirat, P.; Hallfors, D.; Cho, H.; Brodish, P.

    2007-01-01

    In "a treatment effectiveness trial", a program is evaluated in a real-world setting, with an emphasis on achieving high implementation fidelity. Through fidelity assessment, the link between program implementation and outcomes is systematically evaluated and ultimately leads to a greater understanding of program success or failure. This paper…

  11. Blending Qualitative and Computational Linguistics Methods for Fidelity Assessment: Experience with the Familias Unidas Preventive Intervention.

    PubMed

    Gallo, Carlos; Pantin, Hilda; Villamar, Juan; Prado, Guillermo; Tapia, Maria; Ogihara, Mitsunori; Cruden, Gracelyn; Brown, C Hendricks

    2015-09-01

    Careful fidelity monitoring and feedback are critical to implementing effective interventions. A wide range of procedures exist to assess fidelity; most are derived from observational assessments (Schoenwald and Garland, Psycholog Assess 25:146-156, 2013). However, these fidelity measures are resource intensive for research teams in efficacy/effectiveness trials, and are often unattainable or unmanageable for the host organization to rate when the program is implemented on a large scale. We present a first step towards automated processing of linguistic patterns in fidelity monitoring of a behavioral intervention using an innovative mixed methods approach to fidelity assessment that uses rule-based, computational linguistics to overcome major resource burdens. Data come from an effectiveness trial of the Familias Unidas intervention, an evidence-based, family-centered preventive intervention found to be efficacious in reducing conduct problems, substance use and HIV sexual risk behaviors among Hispanic youth. This computational approach focuses on "joining," which measures the quality of the working alliance of the facilitator with the family. Quantitative assessments of reliability are provided. Kappa scores between a human rater and a machine rater for the new method for measuring joining reached 0.83. Early findings suggest that this approach can reduce the high cost of fidelity measurement and the time delay between fidelity assessment and feedback to facilitators; it also has the potential for improving the quality of intervention fidelity ratings.

  12. Specification of Training Simulator Fidelity: A Research Plan. Technical Report 558.

    ERIC Educational Resources Information Center

    Baum, David R.; And Others

    This report presents a research plan to guide the determination of the empirical relationship between level of maintenance training simulator fidelity and training effectiveness. Chapter I describes data collection and analysis activities undertaken to provide guidance for fidelity decision making by the training simulator development community.…

  13. Fidelity in After-School Program Intervention Research: A Systematic Review

    ERIC Educational Resources Information Center

    Maynard, Brandy R.; Peters, Kristen E.; Vaughn, Michael G.; Sarteschi, Christine M.

    2014-01-01

    Over the past 2 decades, the number of after-school programs (ASP) and the number of students attending ASPs has markedly increased. Although several reviews and meta-analyses have examined the outcomes of ASPs, ASP intervention study reviews have not specifically examined intervention fidelity. Establishing intervention fidelity is critically…

  14. Assessment of Fidelity in Interventions to Improve Hand Hygiene of Healthcare Workers: A Systematic Review

    PubMed Central

    Musuuza, Jackson S.; Barker, Anna; Ngam, Caitlyn; Vellardita, Lia; Safdar, Nasia

    2016-01-01

    OBJECTIVE Compliance with hand hygiene in healthcare workers is fundamental to infection prevention yet remains a challenge to sustain. We examined fidelity reporting in interventions to improve hand hygiene compliance, and we assessed 5 measures of intervention fidelity: (1) adherence, (2) exposure or dose, (3) quality of intervention delivery, (4) participant responsiveness, and (5) program differentiation. DESIGN Systematic review METHODS A librarian performed searches of the literature in PubMed, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Library, and Web of Science of material published prior to June 19, 2015. The review protocol was registered in PROSPERO International Prospective Register of Systematic Reviews, and assessment of study quality was conducted for each study reviewed. RESULTS A total of 100 studies met the inclusion criteria. Only 8 of these 100 studies reported all 5 measures of intervention fidelity. In addition, 39 of 100 (39%) failed to include at least 3 fidelity measures; 20 of 100 (20%) failed to include 4 measures; 17 of 100 (17%) failed to include 2 measures, while 16 of 100 (16%) of the studies failed to include at least 1 measure of fidelity. Participant responsiveness and adherence to the intervention were the most frequently unreported fidelity measures, while quality of the delivery was the most frequently reported measure. CONCLUSIONS Almost all hand hygiene intervention studies failed to report at least 1 fidelity measurement. To facilitate replication and effective implementation, reporting fidelity should be standard practice when describing results of complex behavioral interventions such as hand hygiene. PMID:26861117

  15. Validation of the Standard Mobility Application Programming Interface Fidelity 1 and 2

    DTIC Science & Technology

    2006-07-01

    Speed Differences and Standard Deviations for Terrain 13CD300A (mph) .............................................................. 43 28. T -72...A -4 30. T -72 Fidelity 1 vs. Fidelity 2 Prediction Delta {Climate Zone 4, Cross-Country, Dry...A -5 31. T -72 STNDMob Over / Even / Under-Predictions {Climate Zone 4, Cross-Country, Dry

  16. An Investigation of the Effectiveness of Training Devices With Varying Degrees of Fidelity.

    ERIC Educational Resources Information Center

    Grunwald, Walter

    A study was made of the relative effectiveness of five selected training devices with varying degrees of fidelity in the learning of a psychomotor task in which manipulative skill was not vital. The hypothesis was this: an increase in fidelity may not produce a corresponding increase in effectiveness, whereas such factors as ability to engage a…

  17. Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

    PubMed Central

    Stapleford, Kenneth A.; Rozen-Gagnon, Kathryn; Das, Pratyush Kumar; Saul, Sirle; Poirier, Enzo Z.; Blanc, Hervé; Vidalain, Pierre-Olivier; Merits, Andres

    2015-01-01

    ABSTRACT To date, the majority of work on RNA virus replication fidelity has focused on the viral RNA polymerase, while the potential role of other viral replicase proteins in this process is poorly understood. Previous studies used resistance to broad-spectrum RNA mutagens, such as ribavirin, to identify polymerases with increased fidelity that avoid misincorporation of such base analogues. We identified a novel variant in the alphavirus viral helicase/protease, nonstructural protein 2 (nsP2) that operates in concert with the viral polymerase nsP4 to further alter replication complex fidelity, a functional linkage that was conserved among the alphavirus genus. Purified chikungunya virus nsP2 presented delayed helicase activity of the high-fidelity enzyme, and yet purified replication complexes manifested stronger RNA polymerization kinetics. Because mutagenic nucleoside analogs such as ribavirin also affect intracellular nucleotide pools, we addressed the link between nucleotide depletion and replication fidelity by using purine and pyrimidine biosynthesis inhibitors. High-fidelity viruses were more resistant to these conditions, and viral growth could be rescued by the addition of exogenous nucleosides, suggesting that mutagenesis by base analogues requires nucleotide pool depletion. This study describes a novel function for nsP2, highlighting the role of other components of the replication complex in regulating viral replication fidelity, and suggests that viruses can alter their replication complex fidelity to overcome intracellular nucleotide-depleting conditions. IMPORTANCE Previous studies using the RNA mutagen ribavirin to select for drug-resistant variants have highlighted the essential role of the viral RNA-dependent RNA polymerase in regulating replication fidelity. However, the role of other viral replicase components in replication fidelity has not been studied in detail. We identified here an RNA mutagen-resistant variant of the nsP2 helicase

  18. Comparing the Costs and Acceptability of Three Fidelity Assessment Methods for Assertive Community Treatment.

    PubMed

    Rollins, Angela L; Kukla, Marina; Salyers, Michelle P; McGrew, John H; Flanagan, Mindy E; Leslie, Doug L; Hunt, Marcia G; McGuire, Alan B

    2017-01-04

    Successful implementation of evidence-based practices requires valid, yet practical fidelity monitoring. This study compared the costs and acceptability of three fidelity assessment methods: on-site, phone, and expert-scored self-report. Thirty-two randomly selected VA mental health intensive case management teams completed all fidelity assessments using a standardized scale and provided feedback on each. Personnel and travel costs across the three methods were compared for statistical differences. Both phone and expert-scored self-report methods demonstrated significantly lower costs than on-site assessments, even when excluding travel costs. However, participants preferred on-site assessments. Remote fidelity assessments hold promise in monitoring large scale program fidelity with limited resources.

  19. Electron-exchange and quantum screening effects on the collisional entanglement fidelity in degenerate quantum plasmas

    NASA Astrophysics Data System (ADS)

    Hong, Woo-Pyo; Jung, Young-Dae

    2014-06-01

    The influence of electron-exchange and quantum screening on the collisional entanglement fidelity for the elastic electron-ion collision is investigated in degenerate quantum plasmas. The effective Shukla-Eliasson potential and the partial wave method are used to obtain the collisional entanglement fidelity in quantum plasmas as a function of the electron-exchange parameter, Fermi energy, plasmon energy and collision energy. The results show that the quantum screening effect enhances the entanglement fidelity in quantum plasmas. However, it is found that the electron-exchange effect strongly suppresses the collisional entanglement fidelity. Hence, we have found that the influence of the electron-exchange reduces the transmission of quantum information in quantum plasmas. In addition, it is found that, although the entanglement fidelity decreases with an increase of the Fermi energy, it increases with increasing plasmon energy in degenerate quantum plasmas.

  20. Sources of variation in survival and breeding site fidelity in three species of European ducks

    USGS Publications Warehouse

    Blums, P.; Nichols, J.D.; Hines, J.E.

    2002-01-01

    1. We used long-term capture-recapture-recovery data and a modelling approach developed by Burnham (1993) to test a priori predictions about sources of variation in annual survival rates and fidelity within a population of individually marked females in three species of European ducks from a breeding ground study site in Latvia. 2. True annual survival was higher for diving ducks (tufted duck 0-72, common pochard 0-65) and lower for northern shoveler (0-52). Survival of female diving ducks was positively correlated with mean winter temperatures at Western European wintering areas, the relationship being much stronger for pochard. 3. We present the first unbiased estimates of breeding fidelity and permanent emigration in European ducks. Estimated fidelity rates were high (0'88-1-0) and emigration rates low (0-0-12) for all three species, and we found strong evidence for age-specific differences in fidelity of pochards. Unusual long-distance (up to 2500 km) breeding dispersal movements that we found in female tufted ducks have not been documented in any other European waterfowl and are most probably a result of saturated nesting habitats. 4. Fidelity was a function of patch reproductive success in the previous year for all three species providing support for the idea that patch success is an important cue influencing fidelity. 5. Fidelity probability increased to 1.0 for shovelers during the last 12 years of study following provision of critical improvements in nesting habitats and suggested that habitat conditions and reproductive success determined site fidelity and settling patterns for shoveler and probably also influenced fidelity of the two other species. In predictable habitats, fidelity is a parameter that reflects the integration of fitness components and is thus a good quantity for assessing the effectiveness of habitat management actions.

  1. DISTRIBUTED AMPLIFIER INCORPORATING FEEDBACK

    DOEpatents

    Bell, P.R. Jr.

    1958-10-21

    An improved distributed amplifier system employing feedback for stabilization is presented. In accordance with the disclosed invention, a signal to be amplified is applled to one end of a suitable terminated grid transmission line. At intervals along the transmission line, the signal is fed to stable, resistance-capacitance coupled amplifiers incorporating feedback loops therein. The output current from each amplifier is passed through an additional tube to minimize the electrostatic capacitance between the tube elements of the last stage of the amplifier, and fed to appropriate points on an output transmission line, similar to the grid line, but terminated at the opposite (input) end. The output taken from the unterminated end of the plate transmission line is proportional to the input voltage impressed upon the grid line.

  2. Evidence-Based Practice in School Substance Use Prevention: Fidelity of Implementation under Real-World Conditions

    ERIC Educational Resources Information Center

    Ennett, S. T.; Haws, S.; Ringwalt, C. L.; Vincus, A. A.; Hanley, S.; Bowling, J. M.; Rohrbach, L. A.

    2011-01-01

    Fidelity of program implementation under real-world conditions is a critical issue in the dissemination of evidence-based school substance use prevention curricula. Program effects are diminished when programs are implemented with poor fidelity. We assessed five domains of fidelity--adherence, exposure (dosage), quality of delivery, participant…

  3. Increasing the Rigor of Procedural Fidelity Assessment: An Empirical Comparison of Direct Observation and Permanent Product Review Methods

    ERIC Educational Resources Information Center

    Sanetti, Lisa M. Hagermoser; Collier-Meek, Melissa A.

    2014-01-01

    Although it is widely accepted that procedural fidelity data are important for making valid decisions about intervention effectiveness, there is little empirical guidance for researchers and practitioners regarding how to assess procedural fidelity. A first step in moving procedural fidelity assessment research forward is to develop a…

  4. First-Order Model Management With Variable-Fidelity Physics Applied to Multi-Element Airfoil Optimization

    NASA Technical Reports Server (NTRS)

    Alexandrov, N. M.; Nielsen, E. J.; Lewis, R. M.; Anderson, W. K.

    2000-01-01

    First-order approximation and model management is a methodology for a systematic use of variable-fidelity models or approximations in optimization. The intent of model management is to attain convergence to high-fidelity solutions with minimal expense in high-fidelity computations. The savings in terms of computationally intensive evaluations depends on the ability of the available lower-fidelity model or a suite of models to predict the improvement trends for the high-fidelity problem, Variable-fidelity models can be represented by data-fitting approximations, variable-resolution models. variable-convergence models. or variable physical fidelity models. The present work considers the use of variable-fidelity physics models. We demonstrate the performance of model management on an aerodynamic optimization of a multi-element airfoil designed to operate in the transonic regime. Reynolds-averaged Navier-Stokes equations represent the high-fidelity model, while the Euler equations represent the low-fidelity model. An unstructured mesh-based analysis code FUN2D evaluates functions and sensitivity derivatives for both models. Model management for the present demonstration problem yields fivefold savings in terms of high-fidelity evaluations compared to optimization done with high-fidelity computations alone.

  5. Fidelity of implementation: development and testing of a measure

    PubMed Central

    2010-01-01

    Background Along with the increasing prevalence of chronic illness has been an increase in interventions, such as nurse case management programs, to improve outcomes for patients with chronic illness. Evidence supports the effectiveness of such interventions in reducing patient morbidity, mortality, and resource utilization, but other studies have produced equivocal results. Often, little is known about how implementation of an intervention actually occurs in clinical practice. While studies often assume that interventions are used in clinical practice exactly as originally designed, this may not be the case. Thus, fidelity of an intervention's implementation reflects how an intervention is, or is not, used in clinical practice and is an important factor in understanding intervention effectiveness and in replicating the intervention in dissemination efforts. The purpose of this paper is to contribute to the understanding of implementation science by (a) proposing a methodology for measuring fidelity of implementation (FOI) and (b) testing the measure by examining the association between FOI and intervention effectiveness. Methods We define and measure FOI based on organizational members' level of commitment to using the distinct components that make up an intervention as they were designed. Semistructured interviews were conducted among 18 organizational members in four medical centers, and the interviews were analyzed qualitatively to assess three dimensions of commitment to use--satisfaction, consistency, and quality--and to develop an overall rating of FOI. Mixed methods were used to explore the association between FOI and intervention effectiveness (inpatient resource utilization and mortality). Results Predictive validity of the FOI measure was supported based on the statistical significance of FOI as a predictor of intervention effectiveness. The strongest relationship between FOI and intervention effectiveness was found when an alternative measure of FOI was

  6. Creation of a Rapid High-Fidelity Aerodynamics Module for a Multidisciplinary Design Environment

    NASA Technical Reports Server (NTRS)

    Srinivasan, Muktha; Whittecar, William; Edwards, Stephen; Mavris, Dimitri N.

    2012-01-01

    In the traditional aerospace vehicle design process, each successive design phase is accompanied by an increment in the modeling fidelity of the disciplinary analyses being performed. This trend follows a corresponding shrinking of the design space as more and more design decisions are locked in. The correlated increase in knowledge about the design and decrease in design freedom occurs partly because increases in modeling fidelity are usually accompanied by significant increases in the computational expense of performing the analyses. When running high fidelity analyses, it is not usually feasible to explore a large number of variations, and so design space exploration is reserved for conceptual design, and higher fidelity analyses are run only once a specific point design has been selected to carry forward. The designs produced by this traditional process have been recognized as being limited by the uncertainty that is present early on due to the use of lower fidelity analyses. For example, uncertainty in aerodynamics predictions produces uncertainty in trajectory optimization, which can impact overall vehicle sizing. This effect can become more significant when trajectories are being shaped by active constraints. For example, if an optimal trajectory is running up against a normal load factor constraint, inaccuracies in the aerodynamic coefficient predictions can cause a feasible trajectory to be considered infeasible, or vice versa. For this reason, a trade must always be performed between the desired fidelity and the resources available. Apart from this trade between fidelity and computational expense, it is very desirable to use higher fidelity analyses earlier in the design process. A large body of work has been performed to this end, led by efforts in the area of surrogate modeling. In surrogate modeling, an up-front investment is made by running a high fidelity code over a Design of Experiments (DOE); once completed, the DOE data is used to create a

  7. mHealth interventions for weight loss: a guide for achieving treatment fidelity

    PubMed Central

    Shaw, Ryan J; Steinberg, Dori M; Zullig, Leah L; Bosworth, Hayden B; Johnson, Constance M; Davis, Linda L

    2014-01-01

    mHealth interventions have shown promise for helping people sustain healthy behaviors such as weight loss. However, few have assessed treatment fidelity, that is, the accurate delivery, receipt, and enactment of the intervention. Treatment fidelity is critical because the valid interpretation and translation of intervention studies depend on treatment fidelity assessments. We describe strategies used to assess treatment fidelity in mobile health (mHealth) interventions aimed at sustaining healthy behaviors in weight loss. We reviewed treatment fidelity recommendations for mHealth-based behavioral interventions and described how these recommendations were applied in three recent weight loss studies. We illustrate how treatment fidelity can be supported during study design, training of providers, treatment delivery, receipt of treatment, and enactment of treatment skills. Pre-planned strategies to ensure the treatment fidelity of mHealth interventions will help counter doubts concerning valid conclusions about their effectiveness and allow investigators and clinicians to implement robustly efficacious mobile health programs. Trial registration number 1F31 NR012599. PMID:24853065

  8. Scaling of ground-state fidelity in the thermodynamic limit: XY model and beyond

    SciTech Connect

    Rams, Marek M.; Damski, Bogdan

    2011-09-15

    We study ground-state fidelity defined as the overlap between two ground states of the same quantum system obtained for slightly different values of the parameters of its Hamiltonian. We focus on the thermodynamic regime of the XY model and the neighborhood of its critical points. We describe extensively fidelity when it is dominated by the universal contribution reflecting the quantum criticality of the phase transition. We show that proximity to the multicritical point leads to anomalous scaling of fidelity. We also discuss fidelity in a regime characterized by pronounced oscillations resulting from the change in either the system size or the parameters of the Hamiltonian. Moreover, we show when fidelity is dominated by non-universal contributions, study fidelity in the extended Ising model, and illustrate how our results provide additional insight into dynamics of quantum phase transitions. Special attention is given to studies of fidelity from the momentum space perspective. All our main results are obtained analytically. They are in excellent agreement with numerics.

  9. Systematic evaluation of implementation fidelity of complex interventions in health and social care

    PubMed Central

    2010-01-01

    Background Evaluation of an implementation process and its fidelity can give insight into the 'black box' of interventions. However, a lack of standardized methods for studying fidelity and implementation process have been reported, which might be one reason for the fact that few prior studies in the field of health service research have systematically evaluated interventions' implementation processes. The aim of this project is to systematically evaluate implementation fidelity and possible factors influencing fidelity of complex interventions in health and social care. Methods A modified version of The Conceptual Framework for Implementation Fidelity will be used as a conceptual model for the evaluation. The modification implies two additional moderating factors: context and recruitment. A systematic evaluation process was developed. Multiple case study method is used to investigate implementation of three complex health service interventions. Each case will be investigated in depth and longitudinally, using both quantitative and qualitative methods. Discussion This study is the first attempt to empirically test The Conceptual Framework for Implementation Fidelity. The study can highlight mechanism and factors of importance when implementing complex interventions. Especially the role of the moderating factors on implementation fidelity can be clarified. Trial Registration Supported Employment, SE, among people with severe mental illness -- a randomized controlled trial: NCT00960024. PMID:20815872

  10. Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity

    PubMed Central

    Zhu, Jin; Heinecke, Dominic; Mulla, Wahid A.; Bradford, William D.; Rubinstein, Boris; Box, Andrew; Haug, Jeffrey S.; Li, Rong

    2015-01-01

    Errors in mitosis are a primary cause of chromosome instability (CIN), generating aneuploid progeny cells. Whereas a variety of factors can influence CIN, under most conditions mitotic errors are rare events that have been difficult to measure accurately. Here we report a green fluorescent protein−based quantitative chromosome transmission fidelity (qCTF) assay in budding yeast that allows sensitive and quantitative detection of CIN and can be easily adapted to high-throughput analysis. Using the qCTF assay, we performed genome-wide quantitative profiling of genes that affect CIN in a dosage-dependent manner and identified genes that elevate CIN when either increased (icCIN) or decreased in copy number (dcCIN). Unexpectedly, qCTF screening also revealed genes whose change in copy number quantitatively suppress CIN, suggesting that the basal error rate of the wild-type genome is not minimized, but rather, may have evolved toward an optimal level that balances both stability and low-level karyotype variation for evolutionary adaptation. PMID:25823586

  11. High fidelity imaging of geosynchronous satellites with the MROI

    NASA Astrophysics Data System (ADS)

    Young, John; Haniff, Christopher; Buscher, David; Creech-Eakman, Michelle; Payne, Ifan

    2016-08-01

    Interferometry currently provides the only practicable way to image satellites in Geosynchronous Earth Orbit (GEO) with sub-meter spatial resolution. The Magdalena Ridge Observatory Interferometer (MROI) is being funded by the US Air Force Research Laboratory to demonstrate the 9.5 magnitude sensitivity (at 2.2 μm wavelength) and baseline-bootstrapping capability that will be needed to realize a useful turn-key GEO imaging capability. This program will utilize the central three telescopes of the MROI and will aim to validate routine acquisition of fringe data on faint well-resolved targets. In parallel with this effort, the University of Cambridge are investigating the spatial resolution and imaging fidelity that can be achieved with different numbers of array elements. We present preliminary simulations of snapshot GEO satellite imaging with the MROI. Our results indicate that faithful imaging of the main satellite components can be obtained with as few as 7 unit telescopes, and that increasing the number of telescopes to 10 improves the effective spatial resolution from 0.75 meter to 0.5 meter and enables imaging of more complex targets.

  12. The Fidelity of Ocean Models With Explicit Eddies (Chapter 17)

    SciTech Connect

    McClean, J; Jayne, S; Maltrud, M; Ivanova, D

    2007-08-01

    Current practices within the oceanographic community have been reviewed with regard to the use of metrics to assess the realism of the upper-ocean circulation, ventilation processes diagnosed by time-evolving mixed layer depth and mode water formation, and eddy heat fluxes in large-scale fine resolution ocean model simulations. We have striven to understand the fidelity of these simulations in the context of their potential use in future fine-resolution coupled climate system studies. A variety of methodologies are used to assess the veracity of the numerical simulations. Sea surface height variability and the location of western boundary current paths from altimetry have been used routinely as basic indicators of fine-resolution model performance. Drifters and floats have also been used to provide pseudo-Eulerian measures of the mean and variability of surface and sub-surface flows, while statistical comparisons of observed and simulated means have been carried out using James tests. Probability density functions have been used to assess the Gaussian nature of the observed and simulated flows. Length and time scales have been calculated in both Eulerian and Lagrangian frameworks from altimetry and drifters, respectively. Concise measures of multiple model performance have been obtained from Taylor diagrams. The time-evolution of the mixed layer depth at monitoring stations has been compared with simulated time series. Finally, eddy heat fluxes are compared to climatological inferences.

  13. Increased Fidelity in Prediction Methods For Landing Gear Noise

    NASA Technical Reports Server (NTRS)

    Lopes, Leonard V.; Brentner, Kenneth S.; Morris, Philip J.; Lockhard, David P.

    2006-01-01

    An aeroacoustic prediction scheme has been developed for landing gear noise. The method is designed to handle the complex landing gear geometry of current and future aircraft. The gear is represented by a collection of subassemblies and simple components that are modeled using acoustic elements. These acoustic elements are generic, but generate noise representative of the physical components on a landing gear. The method sums the noise radiation from each component of the undercarriage in isolation accounting for interference with adjacent components through an estimate of the local upstream and downstream flows and turbulence intensities. The acoustic calculations are made in the code LGMAP, which computes the sound pressure levels at various observer locations. The method can calculate the noise from the undercarriage in isolation or installed on an aircraft for both main and nose landing gear. Comparisons with wind tunnel and flight data are used to initially calibrate the method, then it may be used to predict the noise of any landing gear. In this paper, noise predictions are compared with wind tunnel data for model landing gears of various scales and levels of fidelity, as well as with flight data on fullscale undercarriages. The present agreement between the calculations and measurements suggests the method has promise for future application in the prediction of airframe noise.

  14. High fidelity, radiation tolerant analog-to-digital converters

    NASA Technical Reports Server (NTRS)

    Wang, Charles Chang-I (Inventor); Linscott, Ivan Richard (Inventor); Inan, Umran S. (Inventor)

    2012-01-01

    Techniques for an analog-to-digital converter (ADC) using pipeline architecture includes a linearization technique for a spurious-free dynamic range (SFDR) over 80 deciBels. In some embodiments, sampling rates exceed a megahertz. According to a second approach, a switched-capacitor circuit is configured for correct operation in a high radiation environment. In one embodiment, the combination yields high fidelity ADC (>88 deciBel SFDR) while sampling at 5 megahertz sampling rates and consuming <60 milliWatts. Furthermore, even though it is manufactured in a commercial 0.25-.mu.m CMOS technology (1 .mu.m=12.sup.-6 meters), it maintains this performance in harsh radiation environments. Specifically, the stated performance is sustained through a highest tested 2 megarad(Si) total dose, and the ADC displays no latchup up to a highest tested linear energy transfer of 63 million electron Volts square centimeters per milligram at elevated temperature (131 degrees C.) and supply (2.7 Volts, versus 2.5 Volts nominal).

  15. Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity.

    PubMed

    Zhu, Jin; Heinecke, Dominic; Mulla, Wahid A; Bradford, William D; Rubinstein, Boris; Box, Andrew; Haug, Jeffrey S; Li, Rong

    2015-03-30

    Errors in mitosis are a primary cause of chromosome instability (CIN), generating aneuploid progeny cells. Whereas a variety of factors can influence CIN, under most conditions mitotic errors are rare events that have been difficult to measure accurately. Here we report a green fluorescent protein-based quantitative chromosome transmission fidelity (qCTF) assay in budding yeast that allows sensitive and quantitative detection of CIN and can be easily adapted to high-throughput analysis. Using the qCTF assay, we performed genome-wide quantitative profiling of genes that affect CIN in a dosage-dependent manner and identified genes that elevate CIN when either increased (icCIN) or decreased in copy number (dcCIN). Unexpectedly, qCTF screening also revealed genes whose change in copy number quantitatively suppress CIN, suggesting that the basal error rate of the wild-type genome is not minimized, but rather, may have evolved toward an optimal level that balances both stability and low-level karyotype variation for evolutionary adaptation.

  16. The Creation of a CPU Timer for High Fidelity Programs

    NASA Technical Reports Server (NTRS)

    Dick, Aidan A.

    2011-01-01

    Using C and C++ programming languages, a tool was developed that measures the efficiency of a program by recording the amount of CPU time that various functions consume. By inserting the tool between lines of code in the program, one can receive a detailed report of the absolute and relative time consumption associated with each section. After adapting the generic tool for a high-fidelity launch vehicle simulation program called MAVERIC, the components of a frequently used function called "derivatives ( )" were measured. Out of the 34 sub-functions in "derivatives ( )", it was found that the top 8 sub-functions made up 83.1% of the total time spent. In order to decrease the overall run time of MAVERIC, a launch vehicle simulation program, a change was implemented in the sub-function "Event_Controller ( )". Reformatting "Event_Controller ( )" led to a 36.9% decrease in the total CPU time spent by that sub-function, and a 3.2% decrease in the total CPU time spent by the overarching function "derivatives ( )".

  17. Novel, Synergistic Antifungal Combinations that Target Translation Fidelity

    PubMed Central

    Moreno-Martinez, Elena; Vallieres, Cindy; Holland, Sara L.; Avery, Simon V.

    2015-01-01

    There is an unmet need for new antifungal or fungicide treatments, as resistance to existing treatments grows. Combination treatments help to combat resistance. Here we develop a novel, effective target for combination antifungal therapy. Different aminoglycoside antibiotics combined with different sulphate-transport inhibitors produced strong, synergistic growth-inhibition of several fungi. Combinations decreased the respective MICs by ≥8-fold. Synergy was suppressed in yeast mutants resistant to effects of sulphate-mimetics (like chromate or molybdate) on sulphate transport. By different mechanisms, aminoglycosides and inhibition of sulphate transport cause errors in mRNA translation. The mistranslation rate was stimulated up to 10-fold when the agents were used in combination, consistent with this being the mode of synergistic action. A range of undesirable fungi were susceptible to synergistic inhibition by the combinations, including the human pathogens Candida albicans, C. glabrata and Cryptococcus neoformans, the food spoilage organism Zygosaccharomyces bailii and the phytopathogens Rhizoctonia solani and Zymoseptoria tritici. There was some specificity as certain fungi were unaffected. There was no synergy against bacterial or mammalian cells. The results indicate that translation fidelity is a promising new target for combinatorial treatment of undesirable fungi, the combinations requiring substantially decreased doses of active components compared to each agent alone. PMID:26573415

  18. SPARSE REPRESENTATIONS WITH DATA FIDELITY TERM VIA AN ITERATIVELY REWEIGHTED LEAST SQUARES ALGORITHM

    SciTech Connect

    WOHLBERG, BRENDT; RODRIGUEZ, PAUL

    2007-01-08

    Basis Pursuit and Basis Pursuit Denoising, well established techniques for computing sparse representations, minimize an {ell}{sup 2} data fidelity term subject to an {ell}{sup 1} sparsity constraint or regularization term on the solution by mapping the problem to a linear or quadratic program. Basis Pursuit Denoising with an {ell}{sup 1} data fidelity term has recently been proposed, also implemented via a mapping to a linear program. They introduce an alternative approach via an iteratively Reweighted Least Squares algorithm, providing greater flexibility in the choice of data fidelity term norm, and computational advantages in certain circumstances.

  19. High-fidelity teleportation of continuous-variable quantum states using delocalized single photons.

    PubMed

    Andersen, Ulrik L; Ralph, Timothy C

    2013-08-02

    Traditional continuous-variable teleportation can only approach unit fidelity in the limit of an infinite (and unphysical) amount of squeezing. We describe a new method for continuous-variable teleportation that approaches unit fidelity with finite resources. The protocol is not based on squeezed states as in traditional teleportation but on an ensemble of single photon entangled states. We characterize the teleportation scheme with coherent states, mesoscopic superposition states, and two-mode squeezed states and we find several situations in which near-unity teleportation fidelity can be obtained with modest resources.

  20. EBT Fidelity Trajectories Across Training Cohorts Using the Interagency Collaborative Team Strategy

    PubMed Central

    Hecht, Debra; Aarons, Greg; Fettes, Danielle; Hurlburt, Michael; Ledesma, Karla

    2015-01-01

    The Interdisciplinary Collaborative Team (ICT) strategy uses front-line providers as adaptation, training and quality control agents for multi-agency EBT implementation. This study tests whether an ICT transmits fidelity to subsequent provider cohorts. SafeCare was implemented by home visitors from multiple community-based agencies contracting with child welfare. Client-reported fidelity trajectories for 5,769 visits, 957 clients and 45 providers were compared using three-level growth models. Provider cohorts trained and live-coached by the ICT attained benchmark fidelity after 12 weeks, and this was sustained. Hispanic clients reported high cultural competency, supporting a cultural adaptation crafted by the ICT. PMID:25586878

  1. How to Measure Motivational Interviewing Fidelity in Randomized Controlled Trials: Practical Recommendations.

    PubMed

    Jelsma, Judith G M; Mertens, Vera-Christina; Forsberg, Lisa; Forsberg, Lars

    2015-07-01

    Many randomized controlled trials in which motivational interviewing (MI) is a key intervention make no provision for the assessment of treatment fidelity. This methodological shortcoming makes it impossible to distinguish between high- and low-quality MI interventions, and, consequently, to know whether MI provision has contributed to any intervention effects. This article makes some practical recommendations for the collection, selection, coding and reporting of MI fidelity data, as measured using the Motivational Interviewing Treatment Integrity Code. We hope that researchers will consider these recommendations and include MI fidelity measures in future studies.

  2. Equivalence between entanglement and the optimal fidelity of continuous variable teleportation.

    PubMed

    Adesso, Gerardo; Illuminati, Fabrizio

    2005-10-07

    We devise the optimal form of Gaussian resource states enabling continuous-variable teleportation with maximal fidelity. We show that a nonclassical optimal fidelity of N-user teleportation networks is necessary and sufficient for N-party entangled Gaussian resources, yielding an estimator of multipartite entanglement. The entanglement of teleportation is equivalent to the entanglement of formation in a two-user protocol, and to the localizable entanglement in a multiuser one. Finally, we show that the continuous-variable tangle, quantifying entanglement sharing in three-mode Gaussian states, is defined operationally in terms of the optimal fidelity of a tripartite teleportation network.

  3. Recommendations on Model Fidelity for Wind Turbine Gearbox Simulations; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    Keller, J.; Lacava, W.; Austin, J.; Nejad, A.; Halse, C.; Bastard, L.; Helsen, J.

    2015-02-01

    This work investigates the minimum level of fidelity required to accurately simulate wind turbine gearboxes using state-of-the-art design tools. Excessive model fidelity including drivetrain complexity, gearbox complexity, excitation sources, and imperfections, significantly increases computational time, but may not provide a commensurate increase in the value of the results. Essential designparameters are evaluated, including the planetary load-sharing factor, gear tooth load distribution, and sun orbit motion. Based on the sensitivity study results, recommendations for the minimum model fidelities are provided.

  4. EBT Fidelity Trajectories Across Training Cohorts Using the Interagency Collaborative Team Strategy.

    PubMed

    Chaffin, Mark; Hecht, Debra; Aarons, Greg; Fettes, Danielle; Hurlburt, Michael; Ledesma, Karla

    2016-03-01

    The Interdisciplinary Collaborative Team (ICT) strategy uses front-line providers as adaptation, training and quality control agents for multi-agency EBT implementation. This study tests whether an ICT transmits fidelity to subsequent provider cohorts. SafeCare was implemented by home visitors from multiple community-based agencies contracting with child welfare. Client-reported fidelity trajectories for 5,769 visits, 957 clients and 45 providers were compared using three-level growth models. Provider cohorts trained and live-coached by the ICT attained benchmark fidelity after 12 weeks, and this was sustained. Hispanic clients reported high cultural competency, supporting a cultural adaptation crafted by the ICT.

  5. Holographic complexity and fidelity susceptibility as holographic information dual to different volumes in AdS

    NASA Astrophysics Data System (ADS)

    Mazhari, N. S.; Momeni, Davood; Bahamonde, Sebastian; Faizal, Mir; Myrzakulov, Ratbay

    2017-03-01

    The holographic complexity and fidelity susceptibility have been defined as new quantities dual to different volumes in AdS. In this paper, we will use these new proposals to calculate both of these quantities for a variety of interesting deformations of AdS. We obtain the holographic complexity and fidelity susceptibility for an AdS black hole, Janus solution, a solution with cylindrical symmetry, an inhomogeneous background and a hyperscaling violating background. It is observed that the holographic complexity depends on the size of the subsystem for all these solutions and the fidelity susceptibility does not have any such dependence.

  6. Characterization of Flap Edge Noise Radiation from a High-Fidelity Airframe Model

    NASA Technical Reports Server (NTRS)

    Humphreys, William M., Jr.; Khorrami, Mehdi R.; Lockhard, David P.; Neuhart, Dan H.; Bahr, Christopher J.

    2015-01-01

    The results of an experimental study of the noise generated by a baseline high-fidelity airframe model are presented. The test campaign was conducted in the open-jet test section of the NASA Langley 14- by 22-foot Subsonic Tunnel on an 18%-scale, semi-span Gulfstream airframe model incorporating a trailing edge flap and main landing gear. Unsteady surface pressure measurements were obtained from a series of sensors positioned along the two flap edges, and far field acoustic measurements were obtained using a 97-microphone phased array that viewed the pressure side of the airframe. The DAMAS array deconvolution method was employed to determine the locations and strengths of relevant noise sources in the vicinity of the flap edges and the landing gear. A Coherent Output Power (COP) spectral method was used to couple the unsteady surface pressures measured along the flap edges with the phased array output. The results indicate that outboard flap edge noise is dominated by the flap bulb seal cavity with very strong COP coherence over an approximate model-scale frequency range of 1 to 5 kHz observed between the array output and those unsteady pressure sensors nearest the aft end of the cavity. An examination of experimental COP spectra for the inboard flap proved inconclusive, most likely due to a combination of coherence loss caused by decorrelation of acoustic waves propagating through the thick wind tunnel shear layer and contamination of the spectra by tunnel background noise at lower frequencies. Directivity measurements obtained from integration of DAMAS pressure-squared values over defined geometric zones around the model show that the baseline flap and landing gear are only moderately directional as a function of polar emission angle.

  7. Nepal CRS project incorporates.

    PubMed

    1983-01-01

    The Nepal Contraceptive Retail Sales (CRS) Project, 5 years after lauching product sales in June 1978, incorporated as a private, nonprofit company under Nepalese management. The transition was finalized in August 1983. The Company will work through a cooperative agreement with USAID/Kathmandu to complement the national family planning goals as the program continues to provide comtraceptives through retail channels at subsidized prices. Company objectives include: increase contraceptive sales by at least 15% per year; make CRS cost effective and move towards self sufficiency; and explore the possibility of marketing noncontraceptive health products to improve primary health care. After only5 years the program can point to some impressive successes. The number of retial shops selling family planning products increased from 100 in 1978 to over 8000, extending CRS product availability to 66 of the country's 75 districts. Retail sales have climbed dramatically in the 5-year period, from Rs 46,817 in 1978 to Rs 271,039 in 1982. Sales in terms of couple year protection CYP) have grown to 24,451 CYP(1982), a 36% increase over 1980 CYP. Since the beginning of the CRS marketing program, total distribution of contraceptives--through both CRS and the Family Planning Maternal and Child Haelth (FP/MCH) Project--has been increasing. While the FP/MCH program remains the largest distributor,contribution of CRS Products is increasing, indicating that CRS is creating new product acceptors. CRS market share in 1982 was 43% for condoms and 16% for oral contraceptives (OCs). CRS markets 5 products which are subsidized in order to be affordable to consumers as well as attractive to sellers. The initial products launched in June 1978 were Gulaf standard dose OCs and Dhaal lubricated colored condoms. A less expensive lubricates, plain Suki-Dhaal condom was introduced in June 1980 in an attempt to reach poorer rural populations, but rural distribution costs are excessive and Suki

  8. Comparison of Assertive Community Treatment Fidelity Assessment Methods: Reliability and Validity.

    PubMed

    Rollins, Angela L; McGrew, John H; Kukla, Marina; McGuire, Alan B; Flanagan, Mindy E; Hunt, Marcia G; Leslie, Doug L; Collins, Linda A; Wright-Berryman, Jennifer L; Hicks, Lia J; Salyers, Michelle P

    2016-03-01

    Assertive community treatment is known for improving consumer outcomes, but is difficult to implement. On-site fidelity measurement can help ensure model adherence, but is costly in large systems. This study compared reliability and validity of three methods of fidelity assessment (on-site, phone-administered, and expert-scored self-report) using a stratified random sample of 32 mental health intensive case management teams from the Department of Veterans Affairs. Overall, phone, and to a lesser extent, expert-scored self-report fidelity assessments compared favorably to on-site methods in inter-rater reliability and concurrent validity. If used appropriately, these alternative protocols hold promise in monitoring large-scale program fidelity with limited resources.

  9. Relation between physical time-energy cost of a quantum process and its information fidelity

    NASA Astrophysics Data System (ADS)

    Fung, Chi-Hang Fred; Chau, H. F.

    2014-08-01

    A quantum system can be described and characterized by at least two different concepts, namely, its physical and informational properties. Here, we explicitly connect these two concepts, by equating the time-energy cost which is the product of the largest energy of a Hamiltonian of quantum dynamics and the evolution time, and the entanglement fidelity which is the informational difference between an input state and the corresponding output state produced by a quantum channel characterized by the Hamiltonian. Specifically, the worst-case entanglement fidelity between the input and output states is exactly the cosine of the channel's time-energy cost (except when the fidelity is zero). The exactness of our relation makes a strong statement about the intimate connection between information and physics. Our exact result may also be regarded as a time-energy uncertainty relation for the fastest state that achieves a certain fidelity.

  10. The Fidelity of Template-Directed Oligonucleotide Ligation and the Inevitability of Polymerase Function

    NASA Astrophysics Data System (ADS)

    James, Kenneth D.; Ellington, Andrew D.

    1999-08-01

    The first living systems may have employed template-directed oligonucleotide ligation for replication. The utility of oligonucleotide ligation as a mechanism for the origin and evolution of life is in part dependent on its fidelity. We have devised a method for evaluating ligation fidelity in which ligation substrates are selected from random sequence libraries. The fidelities of chemical and enzymatic ligation are compared under a variety of conditions. While reaction conditions can be found that promote high fidelity copying, departure from these conditions leads to error-prone copying. In particular, ligation reactions with shorter oligonucleotide substrates are less efficient but more faithful. These results support a model for origins in which there was selective pressure for template-directed oligonucleotide ligation to be gradually supplanted by mononucleotide polymerization.

  11. Renormalization plasma shielding effects on scattering entanglement fidelity in dense plasmas

    SciTech Connect

    Lee, Gyeong Won; Shim, Jaewon; Jung, Young-Dae

    2014-10-15

    The influence of renormalization plasma screening on the entanglement fidelity for the elastic electron-atom scattering is investigated in partially ionized dense hydrogen plasmas. The partial wave analysis and effective interaction potential are employed to obtain the scattering entanglement fidelity in dense hydrogen plasmas as functions of the collision energy, the Debye length, and the renormalization parameter. It is found that the renormalization plasma shielding enhances the scattering entanglement fidelity. Hence, we show that the transmission of the quantum information can be increased about 10% due to the renormalization shielding effect in dense hydrogen plasmas. It is also found that the renormalization shielding effect on the entanglement fidelity for the electron-atom collision increases with an increase of the collision energy. In addition, the renormalization shielding function increases with increasing collision energy and saturates to the unity with an increase of the Debye length.

  12. High-Fidelity Simulation for Neonatal Nursing Education: An Integrative Review of the Literature.

    PubMed

    Cooper, Allyson

    2015-01-01

    The lack of safe avenues to develop neonatal nursing competencies using human subjects leads to the notion that simulation education for neonatal nurses might be an ideal form of education. This integrative literature review compares traditional, teacher-centered education with high-fidelity simulation education for neonatal nurses. It examines the theoretical frameworks used in neonatal nursing education and outlines the advantages of this type of training, including improving communication and teamwork; providing an innovative pedagogical approach; and aiding in skill acquisition, confidence, and participant satisfaction. The importance of debriefing is also examined. High-fidelity simulation is not without disadvantages, including its significant cost, the time associated with training, the need for very complex technical equipment, and increased faculty resource requirements. Innovative uses of high-fidelity simulation in neonatal nursing education are suggested. High-fidelity simulation has great potential but requires additional research to fully prove its efficacy.

  13. The effect of sound on visual fidelity perception in stereoscopic 3-D.

    PubMed

    Rojas, David; Kapralos, Bill; Hogue, Andrew; Collins, Karen; Nacke, Lennart; Cristancho, Sayra; Conati, Cristina; Dubrowski, Adam

    2013-12-01

    Visual and auditory cues are important facilitators of user engagement in virtual environments and video games. Prior research supports the notion that our perception of visual fidelity (quality) is influenced by auditory stimuli. Understanding exactly how our perception of visual fidelity changes in the presence of multimodal stimuli can potentially impact the design of virtual environments, thus creating more engaging virtual worlds and scenarios. Stereoscopic 3-D display technology provides the users with additional visual information (depth into and out of the screen plane). There have been relatively few studies that have investigated the impact that auditory stimuli have on our perception of visual fidelity in the presence of stereoscopic 3-D. Building on previous work, we examine the effect of auditory stimuli on our perception of visual fidelity within a stereoscopic 3-D environment.

  14. Fidelity freeze for a random matrix model with off-diagonal perturbation.

    PubMed

    Stöckmann, H-J; Kohler, H

    2006-06-01

    The concept of fidelity has been introduced to characterize the stability of a quantum-mechanical system against perturbations. The fidelity amplitude is defined as the overlap integral of a wave packet with itself after the development forth and back under the influence of two slightly different Hamiltonians. It was shown by Prosen and Znidaric in the linear-response approximation that the decay of the fidelity is frozen if the Hamiltonian of the perturbation contains off-diagonal elements only. In the present work the results of Prosen and Znidaric are extended by a supersymmetry calculation to arbitrary strengths of the perturbation for the case of an unperturbed Hamiltonian taken from the Gaussian orthogonal ensemble and a purely imaginary antisymmetric perturbation. It is found that for the exact calculation the freeze of fidelity is only slightly reduced as compared to the linear-response approximation. This may have important consequences for the design of quantum computers.

  15. A New Fidelity: The Supporting Role of USSOUTHCOM in a Post-Castro Cuba

    DTIC Science & Technology

    2008-05-23

    cu.html (accessed 29 March 2008). 4Carlos Alberto Montaner and Ignacio Ramonet , (quote is that of Carlos Montaner) “Was Fidel Good for Cuba...factbook/print/cu.html (accessed 29 March 2008). 10Carlos Alberto Montaner and Ignacio Ramonet , (quote is that of Ignacio Ramonet ) “Was Fidel Good for...http://www.whitehouse.gov/nsc/nss/2006/sectionI.html (accessed 04 April 2008). 17Carlos Alberto Montaner and Ignacio Ramonet , (quote is that of Carlos

  16. High-fidelity teleportation beyond the no-cloning limit and entanglement swapping for continuous variables.

    PubMed

    Takei, Nobuyuki; Yonezawa, Hidehiro; Aoki, Takao; Furusawa, Akira

    2005-06-10

    We experimentally demonstrate continuous-variable quantum teleportation beyond the no-cloning limit. We teleport a coherent state and achieve the fidelity of 0.70 +/- 0.02 that surpasses the no-cloning limit of 2/3. Surpassing the limit is necessary to transfer the nonclassicality of an input quantum state. By using our high-fidelity teleporter, we demonstrate entanglement swapping, namely, teleportation of quantum entanglement, as an example of transfer of nonclassicality.

  17. Simple proof of the quantum benchmark fidelity for continuous-variable quantum devices

    SciTech Connect

    Namiki, Ryo

    2011-04-15

    An experimental success criterion for continuous-variable quantum teleportation and memory is to surpass the limit of the average fidelity achieved by classical measure-and-prepare schemes with respect to a Gaussian-distributed set of coherent states. We present an alternative proof of the classical limit based on the familiar notions of state-channel duality and partial transposition. The present method enables us to produce a quantum-domain criterion associated with a given set of measured fidelities.

  18. Cultured High-Fidelity Three-Dimensional Human Urogenital Tract Carcinomas and Process

    NASA Technical Reports Server (NTRS)

    Goodwin, Thomas J. (Inventor); Prewett, Tacey L. (Inventor); Spaulding, Glenn F. (Inventor); Wolf, David A. (Inventor)

    1998-01-01

    Artificial high-fidelity three-dimensional human urogenital tract carcinomas are propagated under in vitro-microgravity conditions from carcinoma cells. Artificial high-fidelity three-dimensional human urogenital tract carcinomas are also propagated from a coculture of normal urogenital tract cells inoculated with carcinoma cells. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.

  19. Using high-fidelity simulation as a learning strategy in an undergraduate intensive care course.

    PubMed

    Badir, Aysel; Zeybekoğlu, Zuhal; Karacay, Pelin; Göktepe, Nilgün; Topcu, Serpil; Yalcin, Begüm; Kebapci, Ayda; Oban, Gül

    2015-01-01

    Using high-fidelity simulations to facilitate student learning is an uncommon practice in Turkish nursing programs. The aim of the present study was to understand students' perceptions of the use of simulation in nursing courses. Subjects included 36 senior nursing students taking an intensive care course. This study revealed that high-fidelity simulation is an ideal method of promoting learning by helping students transfer theory into practice, build confidence and teamwork, and raise professional awareness.

  20. Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles

    PubMed Central

    Poirier, Enzo Z.; Mounce, Bryan C.; Rozen-Gagnon, Kathryn; Hooikaas, Peter Jan; Stapleford, Kenneth A.; Moratorio, Gonzalo

    2015-01-01

    ABSTRACT Low-fidelity RNA-dependent RNA polymerases for many RNA virus mutators have been shown to confer attenuated phenotypes, presumably due to increased mutation rates. Additionally, for many RNA viruses, replication to high titers results in the production of defective interfering particles (DIs) that also attenuate infection. We hypothesized that fidelity, recombination, and DI production are tightly linked. We show that a Sindbis virus mutator replicating at a high multiplicity of infection manifests an earlier and greater accumulation of DIs than its wild-type counterpart. The isolated DIs interfere with the replication of full-length virus in a dose-dependent manner. Importantly, the ability of the mutator virus to overproduce DIs could be linked to an increased recombination frequency. These data confirm that RNA-dependent RNA polymerase fidelity and recombination are inversely correlated for this mutator. Our findings suggest that defective interference resulting from higher recombination rates may be more detrimental to RNA virus mutators than the increase in mutational burden. IMPORTANCE Replication, adaptation, and evolution of RNA viruses rely in large part on their low-fidelity RNA-dependent RNA polymerase. Viruses artificially modified in their polymerases to decrease fidelity (mutator viruses) are attenuated in vivo, demonstrating the important role of fidelity in viral fitness. However, attenuation was attributed solely to the modification of the viral mutation rate and the accumulation of detrimental point mutations. In this work, we described an additional phenotype of mutator viruses: an increased recombination rate leading to defective interfering particle (DI) overproduction. Because DIs are known for their inhibitory effect on viral replication, our work suggests that fidelity variants may be attenuated in vivo via several mechanisms. This has important implications in the development of fidelity variants as live attenuated vaccine strains

  1. Mutability and mutational spectrum of chromosome transmission fidelity genes.

    PubMed

    Stirling, Peter C; Crisp, Matthew J; Basrai, Munira A; Tucker, Cheryl M; Dunham, Maitreya J; Spencer, Forrest A; Hieter, Philip

    2012-06-01

    It has been more than two decades since the original chromosome transmission fidelity (Ctf) screen of Saccharomyces cerevisiae was published. Since that time the spectrum of mutations known to cause Ctf and, more generally, chromosome instability (CIN) has expanded dramatically as a result of systematic screens across yeast mutant arrays. Here we describe a comprehensive summary of the original Ctf genetic screen and the cloning of the remaining complementation groups as efforts to expand our knowledge of the CIN gene repertoire and its mutability in a model eukaryote. At the time of the original screen, it was impossible to predict either the genes and processes that would be overrepresented in a pool of random mutants displaying a Ctf phenotype or what the entire set of genes potentially mutable to Ctf would be. We show that in a collection of 136 randomly selected Ctf mutants, >65% of mutants map to 13 genes, 12 of which are involved in sister chromatid cohesion and/or kinetochore function. Extensive screening of systematic mutant collections has shown that ~350 genes with functions as diverse as RNA processing and proteasomal activity mutate to cause a Ctf phenotype and at least 692 genes are required for faithful chromosome segregation. The enrichment of random Ctf alleles in only 13 of ~350 possible Ctf genes suggests that these genes are more easily mutable to cause genome instability than the others. These observations inform our understanding of recurring CIN mutations in human cancers where presumably random mutations are responsible for initiating the frequently observed CIN phenotype of tumors.

  2. An olfactory circuit increases the fidelity of visual behavior.

    PubMed

    Chow, Dawnis M; Theobald, Jamie C; Frye, Mark A

    2011-10-19

    Multimodal integration allows neural circuits to be activated in a behaviorally context-specific manner. In the case of odor plume tracking by Drosophila, an attractive odorant increases the influence of yaw-optic flow on steering behavior in flight, which enhances visual stability reflexes, resulting in straighter flight trajectories within an odor plume. However, it is not well understood whether context-specific changes in optomotor behavior are the result of an increased sensitivity to motion inputs (e.g., through increased visual attention) or direct scaling of motor outputs (i.e., increased steering gain). We address this question by examining the optomotor behavior of Drosophila melanogaster in a tethered flight assay and demonstrate that whereas olfactory cues decrease the gain of the optomotor response to sideslip optic flow, they concomitantly increase the gain of the yaw optomotor response by enhancing the animal's ability to follow transient visual perturbations. Furthermore, ablating the mushroom bodies (MBs) of the fly brain via larval hydroxyurea (HU) treatment results in a loss of olfaction-dependent increase in yaw optomotor fidelity. By expressing either tetanus toxin light chain or diphtheria toxin in gal4-defined neural circuits, we were able to replicate the loss of function observed in the HU treatment within the lines expressing broadly in the mushroom bodies, but not within specific mushroom body lobes. Finally, we were able to genetically separate the yaw responses and sideslip responses in our behavioral assay. Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification of a visual reflex that is critical for flight control.

  3. New Universal Rules of Eukaryotic Translation Initiation Fidelity

    PubMed Central

    Zur, Hadas; Tuller, Tamir

    2013-01-01

    The accepted model of eukaryotic translation initiation begins with the scanning of the transcript by the pre-initiation complex from the 5′end until an ATG codon with a specific nucleotide (nt) context surrounding it is recognized (Kozak rule). According to this model, ATG codons upstream to the beginning of the ORF should affect translation. We perform for the first time, a genome-wide statistical analysis, uncovering a new, more comprehensive and quantitative, set of initiation rules for improving the cost of translation and its efficiency. Analyzing dozens of eukaryotic genomes, we find that in all frames there is a universal trend of selection for low numbers of ATG codons; specifically, 16–27 codons upstream, but also 5–11 codons downstream of the START ATG, include less ATG codons than expected. We further suggest that there is selection for anti optimal ATG contexts in the vicinity of the START ATG. Thus, the efficiency and fidelity of translation initiation is encoded in the 5′UTR as required by the scanning model, but also at the beginning of the ORF. The observed nt patterns suggest that in all the analyzed organisms the pre-initiation complex often misses the START ATG of the ORF, and may start translation from an alternative initiation start-site. Thus, to prevent the translation of undesired proteins, there is selection for nucleotide sequences with low affinity to the pre-initiation complex near the beginning of the ORF. With the new suggested rules we were able to obtain a twice higher correlation with ribosomal density and protein levels in comparison to the Kozak rule alone (e.g. for protein levels r = 0.7 vs. r = 0.31; p<10−12). PMID:23874179

  4. Fidelity assessment of a UH-60A simulation on the NASA Ames vertical motion simulator

    NASA Technical Reports Server (NTRS)

    Atencio, Adolph, Jr.

    1993-01-01

    Helicopter handling qualities research requires that a ground-based simulation be a high-fidelity representation of the actual helicopter, especially over the frequency range of the investigation. This experiment was performed to assess the current capability to simulate the UH-60A Black Hawk helicopter on the Vertical Motion Simulator (VMS) at NASA Ames, to develop a methodology for assessing the fidelity of a simulation, and to find the causes for lack of fidelity. The approach used was to compare the simulation to the flight vehicle for a series of tasks performed in flight and in the simulator. The results show that subjective handling qualities ratings from flight to simulator overlap, and the mathematical model matches the UH-60A helicopter very well over the range of frequencies critical to handling qualities evaluation. Pilot comments, however, indicate a need for improvement in the perceptual fidelity of the simulation in the areas of motion and visual cuing. The methodology used to make the fidelity assessment proved useful in showing differences in pilot work load and strategy, but additional work is needed to refine objective methods for determining causes of lack of fidelity.

  5. The Relationship Between Fidelity and Learning in Aviation Training and Assessment

    NASA Technical Reports Server (NTRS)

    Noble, Cliff

    2002-01-01

    Flight simulators can be designed to train pilots or assess their flight performance. Low-Fidelity simulators maximize the initial learning rate of novice pilots and minimize initial costs; whereas, expensive, high-fidelity simulators predict the realworld in-flight performance of expert pilots (Fink & Shriver, 1978 Hays & Singer 1989; Kinkade & Wheaton. 1972). Although intuitively appealing and intellectually convenient to generalize concepts of learning and assessment, what holds true for the role of fidelity in assessment may not always hold true for learning, and vice versa. To bring clarity to this issue, the author distinguishes the role of fidelity in learning from its role in assessment as a function of skill level by applying the hypothesis of Alessi (1988) and reviewing the Laughery, Ditzian, and Houtman (1982) study on simulator validity. Alessi hypothesized that there is it point beyond which one additional unit of flight-simulator fidelity results in a diminished rate of learning. The author of this current paper also suggests the existence of an optimal point beyond which one additional unit of flight-simulator fidelity results in a diminished rate of practical assessment of nonexpert pilot performance.

  6. A multi-fidelity framework for physics based rotor blade simulation and optimization

    NASA Astrophysics Data System (ADS)

    Collins, Kyle Brian

    New helicopter rotor designs are desired that offer increased efficiency, reduced vibration, and reduced noise. Rotor Designers in industry need methods that allow them to use the most accurate simulation tools available to search for these optimal designs. Computer based rotor analysis and optimization have been advanced by the development of industry standard codes known as "comprehensive" rotorcraft analysis tools. These tools typically use table look-up aerodynamics, simplified inflow models and perform aeroelastic analysis using Computational Structural Dynamics (CSD). Due to the simplified aerodynamics, most design studies are performed varying structural related design variables like sectional mass and stiffness. The optimization of shape related variables in forward flight using these tools is complicated and results are viewed with skepticism because rotor blade loads are not accurately predicted. The most accurate methods of rotor simulation utilize Computational Fluid Dynamics (CFD) but have historically been considered too computationally intensive to be used in computer based optimization, where numerous simulations are required. An approach is needed where high fidelity CFD rotor analysis can be utilized in a shape variable optimization problem with multiple objectives. Any approach should be capable of working in forward flight in addition to hover. An alternative is proposed and founded on the idea that efficient hybrid CFD methods of rotor analysis are ready to be used in preliminary design. In addition, the proposed approach recognizes the usefulness of lower fidelity physics based analysis and surrogate modeling. Together, they are used with high fidelity analysis in an intelligent process of surrogate model building of parameters in the high fidelity domain. Closing the loop between high and low fidelity analysis is a key aspect of the proposed approach. This is done by using information from higher fidelity analysis to improve predictions made

  7. Adaptation and Fidelity: a Recipe Analogy for Achieving Both in Population Scale Implementation.

    PubMed

    Kemp, Lynn

    2016-05-01

    Balancing adherence to fidelity of evidence-based programs and adaptation to local context is one of the key debates in the adoption and implementation of effective programs. Concern about maintaining fidelity to achieve outcomes can result in replication of research-based models that can be a poor fit with the real world. Equally, unplanned adaptation can result in program drift away from the core elements needed to achieve outcomes. To support implementation of the Maternal Early Childhood Sustained Home-visiting (MECSH) program in multiple sites in three countries, an analogy was developed to identify how both fidelity and adaptation can be managed and successfully achieved. This article presents the Commonsense Cookery Book Basic Plain Cake with Variations recipe analogy to articulate the dual requirements of both fidelity and adaptation to achieve quality implementation of the MECSH program. Components classified by the analogy include identification of core ingredients, methods, and equipment that contribute to fundamental outcomes and fidelity to the evidence-based program, and a planned, collaborative approach to identification of needed variations to suit locally sourced capacity, needs, and tastes. Quality is achieved by identifying and measuring the core ingredients and the variations. Sourcing local ingredients and honoring of context support sustainability of quality practice. Using this analogy has assisted adopters of the MECSH program to understand that effective implementation requires uncompromised commitment to expectations of fidelity to the core components and methods; planned, proactive adaptation; systematic monitoring of both core program and agreed variations; and local ownership and sustainability.

  8. Engagement in Training as a Mechanism to Understanding Fidelity of Implementation of the Responsive Classroom Approach.

    PubMed

    Wanless, Shannon B; Rimm-Kaufman, Sara E; Abry, Tashia; Larsen, Ross A; Patton, Christine L

    2015-11-01

    Fidelity of implementation of classroom interventions varies greatly, a reality that is concerning because higher fidelity of implementation relates to greater effectiveness of the intervention. We analyzed 126 fourth and fifth grade teachers from the treatment group of a randomized controlled trial of the Responsive Classroom® (RC) approach. Prior to training in the intervention, we assessed factors that had the potential to represent a teacher's readiness to implement with fidelity. These included teachers' observed emotional support, teacher-rated use of intervention practices, teacher-rated self-efficacy, teacher-rated collective responsibility, education level, and years of experience, and they were not directly related to observed fidelity of implementation 2 years later. Further analyses indicated, however, that RC trainers' ratings of teachers' engagement in the initial weeklong RC training mediated the relation between initial observed emotional support and later observed fidelity of implementation. We discuss these findings as a way to advance understanding of teachers' readiness to implement new interventions with fidelity.

  9. High Fidelity System Simulation of Multiple Components in Support of the UEET Program

    NASA Technical Reports Server (NTRS)

    Plybon, Ronald C.; VanDeWall, Allan; Sampath, Rajiv; Balasubramaniam, Mahadevan; Mallina, Ramakrishna; Irani, Rohinton

    2006-01-01

    The High Fidelity System Simulation effort has addressed various important objectives to enable additional capability within the NPSS framework. The scope emphasized High Pressure Turbine and High Pressure Compressor components. Initial effort was directed at developing and validating intermediate fidelity NPSS model using PD geometry and extended to high-fidelity NPSS model by overlaying detailed geometry to validate CFD against rig data. Both "feedforward" and feedback" approaches of analysis zooming was employed to enable system simulation capability in NPSS. These approaches have certain benefits and applicability in terms of specific applications "feedback" zooming allows the flow-up of information from high-fidelity analysis to be used to update the NPSS model results by forcing the NPSS solver to converge to high-fidelity analysis predictions. This apporach is effective in improving the accuracy of the NPSS model; however, it can only be used in circumstances where there is a clear physics-based strategy to flow up the high-fidelity analysis results to update the NPSS system model. "Feed-forward" zooming approach is more broadly useful in terms of enabling detailed analysis at early stages of design for a specified set of critical operating points and using these analysis results to drive design decisions early in the development process.

  10. The tug-of-war: fidelity versus adaptation throughout the health promotion program life cycle.

    PubMed

    Bopp, Melissa; Saunders, Ruth P; Lattimore, Diana

    2013-06-01

    Researchers across multiple fields have described the iterative and nonlinear phases of the translational research process from program development to dissemination. This process can be conceptualized within a "program life cycle" framework that includes overlapping and nonlinear phases: development, adoption, implementation, maintenance, sustainability or termination, and dissemination or diffusion, characterized by tensions between fidelity to the original plan and adaptation for the setting and population. In this article, we describe the life cycle (phases) for research-based health promotion programs, the key influences at each phase, and the issues related to the tug-of-war between fidelity and adaptation throughout the process using a fictionalized case study based on our previous research. This article suggests the importance of reconceptualizing intervention design, involving stakeholders, and monitoring fidelity and adaptation throughout all phases to maintain implementation fidelity and completeness. Intervention fidelity should be based on causal mechanisms to ensure effectiveness, while allowing for appropriate adaption to ensure maximum implementation and sustainability. Recommendations for future interventions include considering the determinants of implementation including contextual factors at each phase, the roles of stakeholders, and the importance of developing a rigorous, adaptive, and flexible definition of implementation fidelity and completeness.

  11. DNA ligases ensure fidelity by interrogating minor groove contacts.

    PubMed

    Liu, Pingfang; Burdzy, Artur; Sowers, Lawrence C

    2004-01-01

    DNA ligases, found in both prokaryotes and eukaryotes, covalently link the 3'-hydroxyl and 5'-phosphate ends of duplex DNA segments. This reaction represents a completion step for DNA replication, repair and recombination. It is well established that ligases are sensitive to mispairs present on the 3' side of the ligase junction, but tolerant of mispairs on the 5' side. While such discrimination would increase the overall accuracy of DNA replication and repair, the mechanisms by which this fidelity is accomplished are as yet unknown. In this paper, we present the results of experiments with Tth ligase from Thermus thermophilus HB8 and a series of nucleoside analogs in which the mechanism of discrimination has been probed. Using a series of purine analogs substituted in the 2 and 6 positions, we establish that the apparent base pair geometry is much more important than relative base pair stability and that major groove contacts are of little importance. This result is further confirmed using 5-fluorouracil (FU) mispaired with guanine. At neutral pH, the FU:G mispair on the 3' side of a ligase junction is predominantly in a neutral wobble configuration and is poorly ligated. Increasing the solution pH increases the proportion of an ionized base pair approximating Watson-Crick geometry, substantially increasing the relative ligation efficiency. These results suggest that the ligase could distinguish Watson-Crick from mispaired geometry by probing the hydrogen bond acceptors present in the minor groove as has been proposed for DNA polymerases. The significance of minor groove hydrogen bonding interactions is confirmed with both Tth and T4 DNA ligases upon examination of base pairs containing the pyrimidine shape analog, difluorotoluene (DFT). Although DFT paired with adenine approximates Watson-Crick geometry, a minor groove hydrogen bond acceptor is lost. Consistent with this hypothesis, we observe that DFT-containing base pairs inhibit ligation when on the 3' side of

  12. Fidelity of the diagonal ensemble signals the many-body localization transition.

    PubMed

    Hu, Taotao; Xue, Kang; Li, Xiaodan; Zhang, Yan; Ren, Hang

    2016-11-01

    In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transition in a random-field Heisenberg chain. We demonstrate that the fidelity and fidelity susceptibility can be utilized to characterize the interaction-driven many-body localization transition in this closed spin system which is in agreement with previous analytical and numerical results [S. Garnerone, N. T. Jacobson, S. Haas, and P. Zanardi, Phys. Rev. Lett. 102, 057205 (2009)PRLTAO0031-900710.1103/PhysRevLett.102.057205; P. Zanardi and N. Paunkovic, Phys. Rev. E 74, 031123 (2006)PLEEE81539-375510.1103/PhysRevE.74.031123]. In particular, instead of ground-state fidelity, we test the fidelity between two diagonal ensembles related by a small parameter perturbation δh, it is special that here the parameter perturbation δh_{i} for each site are random variables like h_{i}. It shows that fidelity of the diagonal ensemble develop a pronounced drop at the transition. We utilize fidelity to estimate the critical disorder strength h_{c} for different system size, we get h_{c}∈ [2.5,3.9] and get a power-law decay with an exponent of roughly -1.49(2) for system size N, and can extrapolate h_{c}^{inf} of the infinite system is about 2.07 which all agree with a recent work by Huse and Pal, in which the MBL transition in the same model was predicted to be hc [2,4]. We also estimate the scaling of maximum of averaged fidelity susceptibility as a function of system size N, it shows a power law increase with an exponent of about 5.05(1).

  13. High Fidelity Virtual Environments: Does Shader Quality or Higher Polygon Count Models Increase Presence and Learning

    NASA Astrophysics Data System (ADS)

    Horton, Scott

    This research study investigated the effects of high fidelity graphics on both learning and presence, or the "sense of being there," inside a Virtual Learning Environment (VLE). Four versions of a VLE on the subject of the element mercury were created, each with a different combination of high and low fidelity polygon models and high and low fidelity shaders. A total of 76 college age (18+ years of age) participants were randomly assigned to one of the four conditions. The participants interacted with the VLE and then completed several posttest measures on learning, presence, and attitudes towards the VLE experience. Demographic information was also collected, including age, computer gameplay experience, number of virtual environments interacted with, gender and time spent in this virtual environment. The data was analyzed as a 2 x 2 between subjects ANOVA. The main effects of shader fidelity and polygon fidelity were both non-significant for both learning and all presence subscales inside the VLE. In addition, there was no significant interaction between shader fidelity and model fidelity. However, there were two significant results on the supplementary variables. First, gender was found to have a significant main effect on all the presence subscales. Females reported higher average levels of presence than their male counterparts. Second, gameplay hours, or the number of hours a participant played computer games per week, also had a significant main effect on participant score on the learning measure. The participants who reported playing 15+ hours of computer games per week, the highest amount of time in the variable, had the highest score as a group on the mercury learning measure while those participants that played 1-5 hours per week had the lowest scores.

  14. Fidelity of the diagonal ensemble signals the many-body localization transition

    NASA Astrophysics Data System (ADS)

    Hu, Taotao; Xue, Kang; Li, Xiaodan; Zhang, Yan; Ren, Hang

    2016-11-01

    In this work, we use exact matrix diagonalization to explore the many-body localization (MBL) transition in a random-field Heisenberg chain. We demonstrate that the fidelity and fidelity susceptibility can be utilized to characterize the interaction-driven many-body localization transition in this closed spin system which is in agreement with previous analytical and numerical results [S. Garnerone, N. T. Jacobson, S. Haas, and P. Zanardi, Phys. Rev. Lett. 102, 057205 (2009), 10.1103/PhysRevLett.102.057205; P. Zanardi and N. Paunkovic, Phys. Rev. E 74, 031123 (2006), 10.1103/PhysRevE.74.031123]. In particular, instead of ground-state fidelity, we test the fidelity between two diagonal ensembles related by a small parameter perturbation δ h , it is special that here the parameter perturbation δ hi for each site are random variables like hi. It shows that fidelity of the diagonal ensemble develop a pronounced drop at the transition. We utilize fidelity to estimate the critical disorder strength hc for different system size, we get hc∈ [2.5,3.9] and get a power-law decay with an exponent of roughly -1.49 (2 ) for system size N , and can extrapolate hcinf of the infinite system is about 2.07 which all agree with a recent work by Huse and Pal, in which the MBL transition in the same model was predicted to be hc [2,4]. We also estimate the scaling of maximum of averaged fidelity susceptibility as a function of system size N , it shows a power law increase with an exponent of about 5.05(1).

  15. Mismatched DNTP Incorporation By DNA Polymerase Beta Does Not Proceed Via Globally Different Conformational Pathways

    SciTech Connect

    Tang, K.-H.; Niebuhr, M.; Tung, C.-S.; Chan, H.-c.; Chou, C.-C.; Tsai, M.-D.

    2009-05-26

    Understanding how DNA polymerases control fidelity requires elucidation of the mechanisms of matched and mismatched dNTP incorporations. Little is known about the latter because mismatched complexes do not crystallize readily. In this report, we employed small-angle X-ray scattering (SAXS) and structural modeling to probe the conformations of different intermediate states of mammalian DNA polymerase {beta} (Pol {beta}) in its wild-type and an error-prone variant, I260Q. Our structural results indicate that the mismatched ternary complex lies in-between the open and the closed forms, but more closely resembles the open form for WT and the closed form for I260Q. On the basis of molecular modeling, this over-stabilization of mismatched ternary complex of I260Q is likely caused by formation of a hydrogen bonding network between the side chains of Gln{sup 260}, Tyr{sup 296}, Glu{sup 295} and Arg{sup 258}, freeing up Asp{sup 192} to coordinate MgdNTP. These results argue against recent reports suggesting that mismatched dNTP incorporations follow a conformational path distinctly different from that of matched dNTP incorporation, or that its conformational closing is a major contributor to fidelity.

  16. Incorporating discrete event simulation into quality improvement efforts in health care systems.

    PubMed

    Rutberg, Matthew Harris; Wenczel, Sharon; Devaney, John; Goldlust, Eric Jonathan; Day, Theodore Eugene

    2015-01-01

    Quality improvement (QI) efforts are an indispensable aspect of health care delivery, particularly in an environment of increasing financial and regulatory pressures. The ability to test predictions of proposed changes to flow, policy, staffing, and other process-level changes using discrete event simulation (DES) has shown significant promise and is well reported in the literature. This article describes how to incorporate DES into QI departments and programs in order to support QI efforts, develop high-fidelity simulation models, conduct experiments, make recommendations, and support adoption of results. The authors describe how DES-enabled QI teams can partner with clinical services and administration to plan, conduct, and sustain QI investigations.

  17. Overview of Plant Incorporated Protectants

    EPA Pesticide Factsheets

    When assessing the potential risks of genetically engineered plant-incorporated protectants, EPA requires extensive studies examining numerous factors. Learn more about the history and process for regulating PIPs.

  18. Image and spectral fidelity study of hyperspectral remote sensing image scaling up based on wavelet transform

    NASA Astrophysics Data System (ADS)

    An, Ni; Ma, Yi; Bao, Yuhai

    2015-08-01

    Wavelet transform is a kind of effective image-scale transformation method, which can achieve multi-scale transformation by distinguishing the low-frequency information and the high-frequency information. Hyperspectral remote sensing data combining image with spectrum has almost continuous spectrum that is the important premise of extracting hyperspectral image information, while scale transformation will inevitably lead to the change of image and spectra. Therefore, it is important to study the image and spectral fidelity after wavelet transform. In this paper, the Proba CHRIS hyperspectral remote sensing image of Yellow River Estuary Wetland is used to investigate the image and spectral fidelity of image transformed by wavelet which remained the low-frequency information. The level 1-3 of up-scale images are obtained and then compared with the original. Then image and spectral fidelity is quantitatively analyzed. The results show that the image fidelity is slightly reduced by up-scale transformation, but near-infrared images have a larger distortion than other bands. With the increasing scaling up, the distortion of spectrum is more and more great, but spectral fidelity is overall well. For the typical wetland objects, Phragmites austrialis has the best spectral correlation, Spartina has a small spectra change, and aquaculture water spectral distortion is most remarkable.

  19. A high-throughput assay for the comprehensive profiling of DNA ligase fidelity.

    PubMed

    Lohman, Gregory J S; Bauer, Robert J; Nichols, Nicole M; Mazzola, Laurie; Bybee, Joanna; Rivizzigno, Danielle; Cantin, Elizabeth; Evans, Thomas C

    2016-01-29

    DNA ligases have broad application in molecular biology, from traditional cloning methods to modern synthetic biology and molecular diagnostics protocols. Ligation-based detection of polynucleotide sequences can be achieved by the ligation of probe oligonucleotides when annealed to a complementary target sequence. In order to achieve a high sensitivity and low background, the ligase must efficiently join correctly base-paired substrates, while discriminating against the ligation of substrates containing even one mismatched base pair. In the current study, we report the use of capillary electrophoresis to rapidly generate mismatch fidelity profiles that interrogate all 256 possible base-pair combinations at a ligation junction in a single experiment. Rapid screening of ligase fidelity in a 96-well plate format has allowed the study of ligase fidelity in unprecedented depth. As an example of this new method, herein we report the ligation fidelity of Thermus thermophilus DNA ligase at a range of temperatures, buffer pH and monovalent cation strength. This screen allows the selection of reaction conditions that maximize fidelity without sacrificing activity, while generating a profile of specific mismatches that ligate detectably under each set of conditions.

  20. An Automatic Medium to High Fidelity Low-Thrust Global Trajectory Toolchain; EMTG-GMAT

    NASA Technical Reports Server (NTRS)

    Beeson, Ryne T.; Englander, Jacob A.; Hughes, Steven P.; Schadegg, Maximillian

    2015-01-01

    Solving the global optimization, low-thrust, multiple-flyby interplanetary trajectory problem with high-fidelity dynamical models requires an unreasonable amount of computational resources. A better approach, and one that is demonstrated in this paper, is a multi-step process whereby the solution of the aforementioned problem is solved at a lower-fidelity and this solution is used as an initial guess for a higher-fidelity solver. The framework presented in this work uses two tools developed by NASA Goddard Space Flight Center: the Evolutionary Mission Trajectory Generator (EMTG) and the General Mission Analysis Tool (GMAT). EMTG is a medium to medium-high fidelity low-thrust interplanetary global optimization solver, which now has the capability to automatically generate GMAT script files for seeding a high-fidelity solution using GMAT's local optimization capabilities. A discussion of the dynamical models as well as thruster and power modeling for both EMTG and GMAT are given in this paper. Current capabilities are demonstrated with examples that highlight the toolchains ability to efficiently solve the difficult low-thrust global optimization problem with little human intervention.

  1. Spawning site fidelity of wild and hatchery lake trout (Salvelinus namaycush) in northern Lake Huron

    USGS Publications Warehouse

    Binder, Thomas; Riley, Stephen C.; Holbrook, Christopher; Hansen, Michael J.; Bergstedt, Roger A.; Bronte, Charles R.; He, Ji; Krueger, Charles C.

    2016-01-01

    Fidelity to high-quality spawning sites helps ensure that adults repeatedly spawn at sites that maximize reproductive success. Fidelity is also an important behavioural characteristic to consider when hatchery-reared individuals are stocked for species restoration, because artificial rearing environments may interfere with cues that guide appropriate spawning site selection. Acoustic telemetry was used in conjunction with Cormack–Jolly–Seber capture–recapture models to compare degree of spawning site fidelity of wild and hatchery-reared lake trout (Salvelinus namaycush) in northern Lake Huron. Annual survival was estimated to be between 77% and 81% and did not differ among wild and hatchery males and females. Site fidelity estimates were high in both wild and hatchery-reared lake trout (ranging from 0.78 to 0.94, depending on group and time filter), but were slightly lower in hatchery-reared fish than in wild fish. The ecological implication of the small difference in site fidelity between wild and hatchery-reared lake trout is unclear, but similarities in estimates suggest that many hatchery-reared fish use similar spawning sites to wild fish and that most return to those sites annually for spawning.

  2. Implementation evaluation of the Blueprint multi-component drug prevention programme: fidelity of school component delivery.

    PubMed

    Stead, Martine; Stradling, Robert; MacNeil, Morag; MacKintosh, Anne Marie; Minty, Sarah

    2007-11-01

    In order to achieve their desired aims, evidence-based, theory-driven drug education programmes need to be implemented as intended. Measurement of 'fidelity of implementation' is now included increasingly as part of programme evaluation, although measures and methods are sometimes limited. A more sophisticated approach to assessing implementation fidelity, based on Dane & Schneider's (1998) five dimensions, was used to examine the classroom curriculum element of the Blueprint programme. Blueprint was the largest and most rigorous evaluation of a multi-component drug prevention programme to date in the United Kingdom. Lessons were, overall, delivered with reasonable fidelity, although teachers did not always understand the thinking behind particular activities, suggesting that training needs to focus not only on content and methods but why particular approaches are important. Different dimensions of fidelity could conflict with one another: under pressure of time, generic elements and processes designed to reflect on learning were sometimes sacrificed in order that core drug education activities could be completed. Future drug education curricula need to build in more flexibility for discussion without compromising core evidence-based elements. Even with substantial training and support, individual variations in delivery were found, although few differences were found between teachers with prior expertise and teachers new to drug education. The methods and measures applied in the Blueprint study all represent attempts to improve on previous measures in terms of both reliability and sensitivity. In this respect the Blueprint study represents a valuable contribution to the science of implementation fidelity.

  3. High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.

    PubMed

    Lloyd, Sarah B; Lichtfuss, Marit; Amarasena, Thakshila H; Alcantara, Sheilajen; De Rose, Robert; Tachedjian, Gilda; Alinejad-Rokny, Hamid; Venturi, Vanessa; Davenport, Miles P; Winnall, Wendy R; Kent, Stephen J

    2016-05-01

    The low fidelity of HIV replication facilitates immune and drug escape. Some reverse transcriptase (RT) inhibitor drug-resistance mutations increase RT fidelity in biochemical assays but their effect during viral replication is unclear. We investigated the effect of RT mutations K65R, Q151N and V148I on SIV replication and fidelity in vitro, along with SIV replication in pigtailed macaques. SIVmac239-K65R and SIVmac239-V148I viruses had reduced replication capacity compared to wild-type SIVmac239. Direct virus competition assays demonstrated a rank order of wild-type>K65R>V148I mutants in terms of viral fitness. In single round in vitro-replication assays, SIVmac239-K65R demonstrated significantly higher fidelity than wild-type, and rapidly reverted to wild-type following infection of macaques. In contrast, SIVmac239-Q151N was replication incompetent in vitro and in pigtailed macaques. Thus, we showed that RT mutants, and specifically the common K65R drug-resistance mutation, had impaired replication capacity and higher fidelity. These results have implications for the pathogenesis of drug-resistant HIV.

  4. The role of treatment fidelity on outcomes during a randomized field trial of an autism intervention.

    PubMed

    Mandell, David S; Stahmer, Aubyn C; Shin, Sujie; Xie, Ming; Reisinger, Erica; Marcus, Steven C

    2013-05-01

    This randomized field trial comparing Strategies for Teaching based on Autism Research and Structured Teaching enrolled educators in 33 kindergarten-through-second-grade autism support classrooms and 119 students, aged 5-8 years in the School District of Philadelphia. Students were assessed at the beginning and end of the academic year using the Differential Ability Scales. Program fidelity was measured through video coding and use of a checklist. Outcomes were assessed using linear regression with random effects for classroom and student. Average fidelity was 57% in Strategies for Teaching based on Autism Research classrooms and 48% in Structured Teaching classrooms. There was a 9.2-point (standard deviation = 9.6) increase in Differential Ability Scales score over the 8-month study period, but no main effect of program. There was a significant interaction between fidelity and group. In classrooms with either low or high program fidelity, students in Strategies for Teaching based on Autism Research experienced a greater gain in Differential Ability Scales score than students in Structured Teaching (11.2 vs. 5.5 points and 11.3 vs. 8.9 points, respectively). In classrooms with moderate fidelity, students in Structured Teaching experienced a greater gain than students in Strategies for Teaching based on Autism Research (10.1 vs. 4.4 points). The results suggest significant variability in implementation of evidence-based practices, even with supports, and also suggest the need to address challenging issues related to implementation measurement in community settings.

  5. The DinB•RecA complex of Escherichia coli mediates an efficient and high-fidelity response to ubiquitous alkylation lesions.

    PubMed

    Cafarelli, Tiziana M; Rands, Thomas J; Godoy, Veronica G

    2014-03-01

    Alkylation DNA lesions are ubiquitous, and result from normal cellular metabolism as well as from treatment with methylating agents and chemotherapeutics. DNA damage tolerance by translesion synthesis DNA polymerases has an important role in cellular resistance to alkylating agents. However, it is not yet known whether Escherichia coli (E. coli) DNA Pol IV (DinB) alkylation lesion bypass efficiency and fidelity in vitro are similar to those inferred by genetic analyses. We hypothesized that DinB-mediated bypass of 3-deaza-3-methyladenine, a stable analog of 3-methyladenine, the primary replication fork-stalling alkylation lesion, would be of high fidelity. We performed here the first kinetic analyses of E. coli DinB•RecA binary complexes. Whether alone or in a binary complex, DinB inserted the correct deoxyribonucleoside triphosphate (dNTP) opposite either lesion-containing or undamaged template; the incorporation of other dNTPs was largely inefficient. DinB prefers undamaged DNA, but the DinB•RecA binary complex increases its catalytic efficiency on lesion-containing template, perhaps as part of a regulatory mechanism to better respond to alkylation damage. Notably, we find that a DinB derivative with enhanced affinity for RecA, either alone or in a binary complex, is less efficient and has a lower fidelity than DinB or DinB•RecA. This finding contrasts our previous genetic analyses. Therefore, mutagenesis resulting from alkylation lesions is likely limited in cells by the activity of DinB•RecA. These two highly conserved proteins play an important role in maintaining genomic stability when cells are faced with ubiquitous DNA damage. Kinetic analyses are important to gain insights into the mechanism(s) regulating TLS DNA polymerases.

  6. High fidelity chemistry and radiation modeling for oxy -- combustion scenarios

    NASA Astrophysics Data System (ADS)

    Abdul Sater, Hassan A.

    Dissipation Concept (EDC) employing a 41-step detailed chemistry mechanism, the non-adiabatic extension of the equilibrium Probability Density Function (PDF) based mixture-fraction model and a two-step global finite rate chemistry model with modified rate constants proposed to work well in oxy-methane flames. Based on the results from this section, the equilibrium PDF model in conjunction with a high-fidelity non-gray model for the radiative properties of the gas-phase may be deemed as accurate to capture the major gas species concentrations, temperatures and flame lengths in oxy-methane flames. The third section examines the variations in radiative transfer predictions due to the choice of chemistry and gas-phase radiative property models. The radiative properties were estimated employing four weighted-sum-of-gray-gases models (WSGGM) that were formulated employing different spectroscopic/model databases. An average variation of 14 -- 17% in the wall incident radiative fluxes was observed between the EDC and equilibrium mixture fraction chemistry models, due to differences in their temperature predictions within the flame. One-dimensional, line-of-sight radiation calculations showed a 15 -- 25 % reduction in the directional radiative fluxes at lower axial locations as a result of ignoring radiation from CO and CH4. Under the constraints of fixed temperature and species distributions, the flame radiant power estimates and average wall incident radiative fluxes varied by nearly 60% and 11% respectively among the different WSGG models.

  7. High Fidelity Tape Transfer Printing Based On Chemically Induced Adhesive Strength Modulation

    PubMed Central

    Sim, Kyoseung; Chen, Song; Li, Yuhang; Kammoun, Mejdi; Peng, Yun; Xu, Minwei; Gao, Yang; Song, Jizhou; Zhang, Yingchun; Ardebili, Haleh; Yu, Cunjiang

    2015-01-01

    Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging to meet the requirements of switchable stamp adhesion. Here we introduce a simple, high fidelity process, namely tape transfer printing(TTP), enabled by chemically induced dramatic modulation in tape adhesive strength. We describe the working mechanism of the adhesion modulation that governs this process and demonstrate the method by high fidelity tape transfer printing several types of materials and devices, including Si pellets arrays, photodetector arrays, and electromyography (EMG) sensors, from their preparation substrates to various alien substrates. High fidelity tape transfer printing of components onto curvilinear surfaces is also illustrated. PMID:26553110

  8. Fidelity to the breeding site in the alpine newt Triturus Alpestris.

    PubMed

    Joly, P; Miaud, C

    1989-06-01

    In a context of several closed breeding sites (archipelago model), the great majority of alpine newts are sedentary, visiting the same site during two successive years. A homing experiment offered the animals a choice between two breeding sites, one from which they came and the other which was inhabited by another population. This experiment demonstrates the fidelity of a great majority of newts for their site of origin. Fidelity was stronger when sites were distant (150 m) than when nearer (25 m). The speed and the probability of return still varied according to both the distance and the nature of the environment of the release point. The performances were better when the animals were released in the wood than when released in the pasture. The mechanisms of orientation and navigation which should explain such results, as well as the genetic consequences of the fidelity, are examined and discussed.

  9. Integrating the Electronic Health Record into high-fidelity interprofessional intensive care unit simulations.

    PubMed

    Gold, Jeffrey A; Tutsch, Alycia S R; Gorsuch, Adriel; Mohan, Vishnu

    2015-01-01

    With the rapid adoption of electronic health records (EHR), there is a growing appreciation for the central role they play in clinical decision making and team communication, with many studies documenting new safety issues with integration of the EHR into the clinical enterprise. To study these issues, we created a high-fidelity simulation instance of our clinical EHR. In this paper, we describe the impact of integrating the EHR into high-fidelity, interprofessional intensive care unit (ICU) simulations, and the errors induced. We found a number of safety issues directly related to the EHR including alert fatigue, negative impacts on interprofessional communication, and problems with selective data gathering, and these issues were present for all members of the interprofessional team. Through successful integration of the EHR into high-fidelity team-based simulations, we now have an infrastructure to focus educational initiative and deploy informatics solutions to mitigate these safety issues.

  10. Role of technology in supporting quality control and treatment fidelity in a family caregiver clinical trial.

    PubMed

    Farran, Carol J; Etkin, Caryn D; McCann, Judith J; Paun, Olimpia; Eisenstein, Amy R; Wilbur, Joellen

    2011-11-01

    This article describes how a family caregiver lifestyle physical activity clinical trial uses research technology to enhance quality control and treatment fidelity. This trial uses a range of Internet, Blaise(®) Windows-based software and Echo Server technologies to support quality control issues, such as data collection, data entry, and study management advocated by the clinical trials literature, and to ensure treatment fidelity concerning intervention implementation (i.e., design, training, delivery, receipt, and enactment) as proposed by the National Institutes of Health Behavior Change Consortium. All research staff are trained to use these technologies. Strengths of this technological approach to support quality control and treatment fidelity include the comprehensive plan, involvement of all staff, and ability to maintain accurate and timely data. Limitations include the upfront time and costs for developing and testing these technological methods, and having support staff readily available to address technological issues if they occur.

  11. Illustrating the multiple facets and levels of fidelity of implementation to a teacher classroom management intervention.

    PubMed

    Reinke, Wendy M; Herman, Keith C; Stormont, Melissa; Newcomer, Lori; David, Kimberly

    2013-11-01

    Many school-based interventions to promote student mental health rely on teachers as implementers. Thus, understanding the interplay between the multiple domains of fidelity to the intervention and intervention support systems such as coaching and teacher implementation of new skills is an important aspect of implementation science. This study describes a systematic process for assessing multiple domains of fidelity. Data from a larger efficacy trial of the Incredible Years Teacher Classroom Management (IY TCM) program are utilized. Data on fidelity to the IY TCM workshop training sessions and onsite weekly coaching indicate that workshop leaders and the IY TCM coach implemented the training and coaching model with adequate adherence. Further, workshop leaders' ratings of engagement were associated with teacher implementation of specific praise, following training on this content. Lastly, the IY TCM coach differentiation of teacher exposure to coaching was evaluated and found to be associated with teacher implementation of classroom management practices and student disruptive behavior.

  12. Use of High Fidelity Methods in Multidisciplinary Optimization-A Preliminary Survey

    NASA Technical Reports Server (NTRS)

    Guruswamy, Guru P.; Kwak, Dochan (Technical Monitor)

    2002-01-01

    Multidisciplinary optimization is a key element of design process. To date multidiscipline optimization methods that use low fidelity methods are well advanced. Optimization methods based on simple linear aerodynamic equations and plate structural equations have been applied to complex aerospace configurations. However, use of high fidelity methods such as the Euler/ Navier-Stokes for fluids and 3-D (three dimensional) finite elements for structures has begun recently. As an activity of Multidiscipline Design Optimization Technical Committee (MDO TC) of AIAA (American Institute of Aeronautics and Astronautics), an effort was initiated to assess the status of the use of high fidelity methods in multidisciplinary optimization. Contributions were solicited through the members MDO TC committee. This paper provides a summary of that survey.

  13. Technical Basis for Physical Fidelity of NRC Control Room Training Simulators for Advanced Reactors

    SciTech Connect

    Minsk, Brian S.; Branch, Kristi M.; Bates, Edward K.; Mitchell, Mark R.; Gore, Bryan F.; Faris, Drury K.

    2009-10-09

    The objective of this study is to determine how simulator physical fidelity influences the effectiveness of training the regulatory personnel responsible for examination and oversight of operating personnel and inspection of technical systems at nuclear power reactors. It seeks to contribute to the U.S. Nuclear Regulatory Commission’s (NRC’s) understanding of the physical fidelity requirements of training simulators. The goal of the study is to provide an analytic framework, data, and analyses that inform NRC decisions about the physical fidelity requirements of the simulators it will need to train its staff for assignment at advanced reactors. These staff are expected to come from increasingly diverse educational and experiential backgrounds.

  14. Designing a practical high-fidelity long-time quantum memory

    NASA Astrophysics Data System (ADS)

    Khodjasteh, Kaveh; Sastrawan, Jarrah; Hayes, David; Green, Todd J.; Biercuk, Michael J.; Viola, Lorenza

    2013-06-01

    Quantum memory is a central component for quantum information processing devices, and will be required to provide high-fidelity storage of arbitrary states, long storage times and small access latencies. Despite growing interest in applying physical-layer error-suppression strategies to boost fidelities, it has not previously been possible to meet such competing demands with a single approach. Here we use an experimentally validated theoretical framework to identify periodic repetition of a high-order dynamical decoupling sequence as a systematic strategy to meet these challenges. We provide analytic bounds—validated by numerical calculations—on the characteristics of the relevant control sequences and show that a ‘stroboscopic saturation’ of coherence, or coherence plateau, can be engineered, even in the presence of experimental imperfection. This permits high-fidelity storage for times that can be exceptionally long, meaning that our device-independent results should prove instrumental in producing practically useful quantum technologies.

  15. High Fidelity Tape Transfer Printing Based On Chemically Induced Adhesive Strength Modulation

    NASA Astrophysics Data System (ADS)

    Sim, Kyoseung; Chen, Song; Li, Yuhang; Kammoun, Mejdi; Peng, Yun; Xu, Minwei; Gao, Yang; Song, Jizhou; Zhang, Yingchun; Ardebili, Haleh; Yu, Cunjiang

    2015-11-01

    Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging to meet the requirements of switchable stamp adhesion. Here we introduce a simple, high fidelity process, namely tape transfer printing(TTP), enabled by chemically induced dramatic modulation in tape adhesive strength. We describe the working mechanism of the adhesion modulation that governs this process and demonstrate the method by high fidelity tape transfer printing several types of materials and devices, including Si pellets arrays, photodetector arrays, and electromyography (EMG) sensors, from their preparation substrates to various alien substrates. High fidelity tape transfer printing of components onto curvilinear surfaces is also illustrated.

  16. Ranging and site fidelity in northern pigtailed macaques (Macaca leonina) over different temporal scales.

    PubMed

    José-Domínguez, Juan Manuel; Savini, Tommaso; Asensio, Norberto

    2015-08-01

    Space-use patterns are crucial to understanding the ecology, evolution, and conservation of primates, but detailed ranging data are scarce for many species, especially those in Southeast Asia. Researchers studying site fidelity to either home ranges or core areas have focused mainly on territorial species, whereas less information is available for non-territorial species. We analyzed the ranging patterns and site fidelity of one wild troop of northern pigtailed macaques over 16 months at different temporal scales. We used characteristic hull polygons in combination with spatial statistics to estimate home ranges and core areas. The total home range and core areas were 449 ha and 190 ha, respectively. Average daily path length was 2,246 m. The macaques showed a high defendabili--ty index according to the expected ranging of a non-territorial species in which movement does not theoretically permit the defense of a large territory. Overall, the study troop ranged more extensively than conspecific groups and closely related species studied elsewhere. These differences may reflect variable troop size, degree of terrestriality and habitat characteristics, but could also reflect methodological differences. The location, size and shape of home ranges and core areas, and extent of daily path lengths changed on a monthly basis resulting in low site fidelity between months. The macaques also showed clear shifts in the location of daily home ranges with low site fidelity scores between consecutive days. Daily home range and daily path length were related to seasonality, with greater values during the fruit-abundant period. Low site fidelity associated with lack of territoriality is consistent with macaques structuring their movement based on available food sources. However, ranging patterns and site fidelity can also be explained by macaques feeding on the move, a foraging strategy that hinders frequent and long visits to the same location.

  17. Ecological correlates of mate fidelity in two Arctic-breeding sandpipers

    USGS Publications Warehouse

    Sandercock, Brett K.; Lank, David B.; Lanctot, Richard B.; Kempenaers, Bart; Cooke, Fred

    2000-01-01

    Monogamous birds exhibit considerable interspecific variation in rates of mate fidelity between years, but the reasons for this variation are still poorly understood. In a 4-year study carried out in western Alaska, mate-fidelity rates in Semipalmated Sandpipers (Calidris pusilla; mate fidelity was 47% among pairs where at least one mate returned and 94% among pairs where both mates returned) were substantially higher than in Western Sandpipers (Calidris mauri; 25 and 67%, respectively), despite the similar breeding biology of these sibling species. Divorce was not a response to nesting failure in Western Sandpipers, and mate change had no effect on the reproductive performance of either species. Nor were mate-fidelity rates related to differential rates of breeding dispersal, because the species did not differ in site fidelity. Reunited pairs and males that changed mates showed strong site tenacity, while females that changed mates moved farther. Differences in local survival rates or habitat are also unlikely to explain mate fidelity, since the two species did not differ in local survival rates, ϕ (Western Sandpipers: ϕ –hat = 0.57 ± 0.05 (mean ± SE), Semipalmated Sandpipers: ϕ –hat = 0.66 ± 0.06), and they bred in the same area, sometimes using the same nest cups. Although we were able to reject the above explanations, it was not possible to determine whether mate retention was lower in Western Sandpipers than in Semipalmated Sandpipers because of interspecific differences in mating tactics, time constraints imposed by migration distance, or a combination of these factors. Western Sandpipers exhibited greater sexual size dimorphism, but also migrated for shorter distances and tended to nest earlier and more asynchronously than Semipalmated Sandpipers. Finally, we show that conventional methods underestimate divorce rates, and interspecific comparisons may be biased if breeding-dispersal and recapture rates are not considered.

  18. A quantum fidelity study of the anisotropic next-nearest-neighbour triangular lattice Heisenberg model.

    PubMed

    Thesberg, Mischa; Sørensen, Erik S

    2014-10-22

    Ground- and excited-state quantum fidelities in combination with generalized quantum fidelity susceptibilites, obtained from exact diagonalizations, are used to explore the phase diagram of the anisotropic next-nearest-neighbour triangular Heisenberg model. Specifically, the J'-J2 plane of this model, which connects the J1-J2 chain and the anisotropic triangular lattice Heisenberg model, is explored using these quantities. Through the use of a quantum fidelity associated with the first excited-state, in addition to the conventional ground-state fidelity, the BKT-type transition and Majumdar-Ghosh point of the J1-J2 chain (J'=0) are found to extend into the J'-J2 plane and connect with points on the J2=0 axis thereby forming bounded regions in the phase diagram. These bounded regions are then explored through the generalized quantum fidelity susceptibilities χρ, χ₁₂₀°, χD and χCAF which are associated with the spin stiffness, 120° spiral order parameter, dimer order parameter and collinear antiferromagnetic order parameter respectively. These quantities are believed to be extremely sensitive to the underlying phase and are thus well suited for finite-size studies. Analysis of the fidelity susceptibilities suggests that the J', J2≪J phase of the anisotropic triangular model is either a collinear antiferromagnet or possibly a gapless disordered phase that is directly connected to the Luttinger phase of the J1-J2 chain. Furthermore, the outer region is dominated by incommensurate spiral physics as well as dimer order.

  19. High Fidelity, Efficiency and Functionalization of Ds-Px Unnatural Base Pairs in PCR Amplification for a Genetic Alphabet Expansion System.

    PubMed

    Okamoto, Itaru; Miyatake, Yuya; Kimoto, Michiko; Hirao, Ichiro

    2016-11-18

    Genetic alphabet expansion of DNA using an artificial extra base pair (unnatural base pair) could augment nucleic acid and protein functionalities by increasing their components. We previously developed an unnatural base pair between 7-(2-thienyl)-imidazo[4,5-b]pyridine (Ds) and 2-nitro-4-propynylpyrrole (Px), which exhibits high fidelity as a third base pair in PCR amplification. Here, the fidelity and efficiency of Ds-Px pairing using modified Px bases with functional groups, such as diol, azide, ethynyl and biotin, were evaluated by an improved method with optimized PCR conditions. The results revealed that all of the base pairs between Ds and either one of the modified Px bases functioned with high amplification efficiency (0.76-0.81), high selectivity (≥99.96% per doubling), and less sequence dependency, in PCR using 3'-exonuclease-proficient Deep Vent DNA polymerase. We also demonstrated that the azide-Px in PCR-amplified DNA was efficiently modified with any functional groups by copper-free click reaction. This genetic alphabet expansion system could endow nucleic acids with a wide variety of increased functionalities by the site-specific incorporation of modified Px bases at desired positions in DNA.

  20. Amplified light storage with high fidelity based on electromagnetically induced transparency in rubidium atomic vapor

    NASA Astrophysics Data System (ADS)

    Zhou, Wei; Wang, Gang; Tang, Guoyu; Xue, Yan

    2016-06-01

    By using slow and stored light based on electromagnetically induced transparency (EIT), we theoretically realize the storage of optical pulses with enhanced efficiency and high fidelity in ensembles of warm atoms in 85Rb vapor cells. The enhancement of storage efficiency is achieved by introducing a pump field beyond three-level configuration to form a N-type scheme, which simultaneously inhibits the undesirable four-wave mixing effect while preserves its fidelity. It is shown that the typical storage efficiency can be improved from 29% to 53% with the application of pump field. Furthermore, we demonstrate that this efficiency decreases with storage time and increases over unity with optical depth.

  1. High fidelity qubit readout with the superconducting low-inductance undulatory galvanometer microwave amplifier

    SciTech Connect

    Hover, D.; Zhu, S.; Thorbeck, T.; Ribeill, G. J.; McDermott, R.; Sank, D.; Kelly, J.; Barends, R.; Martinis, John M.

    2014-04-14

    We describe the high fidelity dispersive measurement of a superconducting qubit using a microwave amplifier based on the Superconducting Low-inductance Undulatory Galvanometer (SLUG). The SLUG preamplifier achieves gain of 19 dB and yields a signal-to-noise ratio improvement of 9 dB over a state-of-the-art HEMT amplifier. We demonstrate a separation fidelity of 99% at 700 ns compared to 59% with the HEMT alone. The SLUG displays a large dynamic range, with an input saturation power corresponding to 700 photons in the readout cavity.

  2. High fidelity qubit readout with the superconducting low-inductance undulatory galvanometer microwave amplifier

    NASA Astrophysics Data System (ADS)

    Hover, D.; Zhu, S.; Thorbeck, T.; Ribeill, G. J.; Sank, D.; Kelly, J.; Barends, R.; Martinis, John M.; McDermott, R.

    2014-04-01

    We describe the high fidelity dispersive measurement of a superconducting qubit using a microwave amplifier based on the Superconducting Low-inductance Undulatory Galvanometer (SLUG). The SLUG preamplifier achieves gain of 19 dB and yields a signal-to-noise ratio improvement of 9 dB over a state-of-the-art HEMT amplifier. We demonstrate a separation fidelity of 99% at 700 ns compared to 59% with the HEMT alone. The SLUG displays a large dynamic range, with an input saturation power corresponding to 700 photons in the readout cavity.

  3. Robust high-fidelity teleportation of an atomic state through the detection of cavity decay

    SciTech Connect

    Yu Bo; Zhou Zhengwei; Zhang Yong; Xiang Guoyong; Guo Guangcan

    2004-07-01

    We propose a scheme for the quantum teleportation of an atomic state based on the detection of cavity decay. The internal state of an atom trapped in a cavity can be disembodiedly transferred to another atom trapped in a distant cavity by measuring interference of polarized photons through single-photon detectors. In comparison with the original proposal by Bose, Knight, Plenio, and Vedral [Phys. Rev. Lett. 83, 5158 (1999)], our protocol of teleportation has a high fidelity of almost unity, and inherent robustness, such as the insensitivity of fidelity to randomness in the atom's position, and to detection inefficiency. All these favorable features make the scheme feasible with the current experimental technology.

  4. Ground-state fidelity and bipartite entanglement in the Bose-Hubbard model.

    PubMed

    Buonsante, P; Vezzani, A

    2007-03-16

    We analyze the quantum phase transition in the Bose-Hubbard model borrowing two tools from quantum-information theory, i.e., the ground-state fidelity and entanglement measures. We consider systems at unitary filling comprising up to 50 sites and show for the first time that a finite-size scaling analysis of these quantities provides excellent estimates for the quantum critical point. We conclude that fidelity is particularly suited for revealing a quantum phase transition and pinning down the critical point thereof, while the success of entanglement measures depends on the mechanisms governing the transition.

  5. High-fidelity readout in circuit quantum electrodynamics using the Jaynes-Cummings nonlinearity.

    PubMed

    Reed, M D; DiCarlo, L; Johnson, B R; Sun, L; Schuster, D I; Frunzio, L; Schoelkopf, R J

    2010-10-22

    We demonstrate a qubit readout scheme that exploits the Jaynes-Cummings nonlinearity of a superconducting cavity coupled to transmon qubits. We find that, in the strongly driven dispersive regime of this system, there is the unexpected onset of a high-transmission "bright" state at a critical power which depends sensitively on the initial qubit state. A simple and robust measurement protocol exploiting this effect achieves a single-shot fidelity of 87% using a conventional sample design and experimental setup, and at least 61% fidelity to joint correlations of three qubits.

  6. Show Me, Don’t Tell Me: Behavioral Rehearsal as a Training and Analogue Fidelity Tool

    PubMed Central

    Beidas, Rinad S.; Cross, Wendi; Dorsey, Shannon

    2013-01-01

    Behavioral rehearsal, when a trainee engages in a simulated interaction with another individual, is an underutilized but potentially cost-effective and feasible solution for two difficult questions in implementation science: how to improve training, a commonly used implementation strategy, and how to feasibly measure fidelity using analogue methods in community settings. This paper provides practical information on how to develop and use behavioral rehearsal for both of these purposes to implementation researchers. Therefore, we focus on development and use of behavioral rehearsal as a training and analogue fidelity tool in the context of three illustrative studies. PMID:25382963

  7. Emotion Focused Therapy-Therapist Fidelity Scale (EFT-TFS): Conceptual Development and Content Validity.

    PubMed

    Denton, Wayne H; Johnson, Susan M; Burleson, Brant R

    2009-07-01

    The Emotion Focused Therapy-Therapist Fidelity Scale (EFT-TFS) is introduced as a scale to measure a therapist's fidelity to the EFT model. The rationale and conceptual development of the scale are presented. Members of an EFT electronic mailing list who participated in a survey (n=130) rated all of the items as highly important for the practice providing support for the content validity of the scale. Finally, the 13 items of the EFT-TFS are presented. Future research directions for the EFT-TFS are presented.

  8. Comment on "Exploring chaos in the Dicke model using ground-state fidelity and Loschmidt echo"

    NASA Astrophysics Data System (ADS)

    García-Mata, Ignacio; Roncaglia, Augusto J.; Wisniacki, Diego A.

    2015-03-01

    In a recent paper [Phys. Rev. E 90, 022920 (2014), 10.1103/PhysRevE.90.022920] a study of the ground-state fidelity of the Dicke model as a function of the coupling parameter is presented. Abrupt jumps of the fidelity in the superradiant phase are observed and are assumed to be related to the transition to chaos. We show that this conclusion results from a misinterpretation of the numerics. In fact, if the parity symmetry is taken into account, the unexpected jumps disappear.

  9. Emotion Focused Therapy-Therapist Fidelity Scale (EFT-TFS): Conceptual Development and Content Validity

    PubMed Central

    Johnson, Susan M.; Burleson, Brant R.

    2009-01-01

    The Emotion Focused Therapy-Therapist Fidelity Scale (EFT-TFS) is introduced as a scale to measure a therapist's fidelity to the EFT model. The rationale and conceptual development of the scale are presented. Members of an EFT electronic mailing list who participated in a survey (n=130) rated all of the items as highly important for the practice providing support for the content validity of the scale. Finally, the 13 items of the EFT-TFS are presented. Future research directions for the EFT-TFS are presented. PMID:20052311

  10. Simulator fidelity and training effectiveness: a comprehensive bibliography with selected annotations

    SciTech Connect

    Rankin, W.L.; Bolton, P.A.; Shikiar, R.; Saari, L.M.

    1984-05-01

    This document contains a comprehensive bibliography on the topic of simulator fidelity and training effectiveness, prepared during the preliminary phases of work on an NRC-sponsored project on the Role of Nuclear Power Plant Simulators in Operator Licensing and Training. Section A of the document is an annotated bibliography consisting of articles and reports with relevance to the psychological aspects of simulator fidelity and the effectiveness of training simulators in a variety of settings, including military. The annotated items are drawn from a more comprehensive bibliography, presented in Section B, listing documents treating the role of simulators in operator training both in the nuclear industry and elsewhere.

  11. Single Molecule Study on Incorporation Efficiency of DPO4 and Klenow Fragment to BPDE Adduct

    NASA Astrophysics Data System (ADS)

    Song, Lu; Yeh, Yin; Balhorn, Rod; Cosman, Monique

    2009-03-01

    DNA synthesis involving high fidelity A-family polymerases such as Klenow fragment is blocked by DNA adducts, while Y-family DNA polymerases such as Dpo4 can bypass the DNA adducts to resume DNA synthesis. So understanding the functional relationship between A-family and Y-family DNA polymerases in DNA replication and the mechanism of bypassing DNA adducts is of great help to explain the cause of mutagenesis. We introduce a flow cell on modified surface to study the incorporation efficiency of Dpo4 and Klenow fragments to benzo[a]pyrene-diol-epoxide (BPDE) adduct at single molecule level. Specifically, we anchor the labeled DNA onto the modified surface with adduct site open for nucleotide incorporation and flow the polymerases and labeled nucleotides into flow cell. With Total Internal Reflection Fluorescence Microscopy (TIRFM) we identify the incorporation of the nucleotides onto the anchored DNA template by identifying the co-localization of the template position and that of the labeled nucleotide. We further quantify the signal densities of the images obtained from the two different polymerases, thus examining whether incorporation reactions have been executed and quantifying the incorporation efficiency of the polymerases. We can also identify, on the specific adduct site, which nucleotide, if any, is incorporated by each of the two polymerases.

  12. The Validity and Incremental Validity of Knowledge Tests, Low-Fidelity Simulations, and High-Fidelity Simulations for Predicting Job Performance in Advanced-Level High-Stakes Selection

    ERIC Educational Resources Information Center

    Lievens, Filip; Patterson, Fiona

    2011-01-01

    In high-stakes selection among candidates with considerable domain-specific knowledge and experience, investigations of whether high-fidelity simulations (assessment centers; ACs) have incremental validity over low-fidelity simulations (situational judgment tests; SJTs) are lacking. Therefore, this article integrates research on the validity of…

  13. Host thin films incorporating nanoparticles

    NASA Astrophysics Data System (ADS)

    Qureshi, Uzma

    The focus of this research project was the investigation of the functional properties of thin films that incorporate a secondary nanoparticulate phase. In particular to assess if the secondary nanoparticulate material enhanced a functional property of the coating on glass. In order to achieve this, new thin film deposition methods were developed, namely use of nanopowder precursors, an aerosol assisted transport technique and an aerosol into atmospheric pressure chemical vapour deposition system. Aerosol assisted chemical vapour deposition (AACVD) was used to deposit 8 series of thin films on glass. Five different nanoparticles silver, gold, ceria, tungsten oxide and zinc oxide were tested and shown to successfully deposit thin films incorporating nanoparticles within a host matrix. Silver nanoparticles were synthesised and doped within a titania film by AACVD. This improved solar control properties. A unique aerosol assisted chemical vapour deposition (AACVD) into atmospheric pressure chemical vapour deposition (APCVD) system was used to deposit films of Au nanoparticles and thin films of gold nanoparticles incorporated within a host titania matrix. Incorporation of high refractive index contrast metal oxide particles within a host film altered the film colour. The key goal was to test the potential of nanopowder forms and transfer the suspended nanopowder via an aerosol to a substrate in order to deposit a thin film. Discrete tungsten oxide nanoparticles or ceria nanoparticles within a titanium dioxide thin film enhanced the self-cleaning and photo-induced super-hydrophilicity. The nanopowder precursor study was extended by deposition of zinc oxide thin films incorporating Au nanoparticles and also ZnO films deposited from a ZnO nanopowder precursor. Incorporation of Au nanoparticles within a VO: host matrix improved the thermochromic response, optical and colour properties. Composite VC/TiC and Au nanoparticle/V02/Ti02 thin films displayed three useful

  14. Selenium incorporation using recombinant techniques

    SciTech Connect

    Walden, Helen

    2010-04-01

    An overview of techniques for recombinant incorporation of selenium and subsequent purification and crystallization of the resulting labelled protein. Using selenomethionine to phase macromolecular structures is common practice in structure determination, along with the use of selenocysteine. Selenium is consequently the most commonly used heavy atom for MAD. In addition to the well established recombinant techniques for the incorporation of selenium in prokaryal expression systems, there have been recent advances in selenium labelling in eukaryal expression, which will be discussed. Tips and things to consider for the purification and crystallization of seleno-labelled proteins are also included.

  15. 17 CFR 260.7a-30 - Identification of material incorporated; form of incorporation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... incorporated; form of incorporation. 260.7a-30 Section 260.7a-30 Commodity and Securities Exchanges SECURITIES... Incorporation by Reference § 260.7a-30 Identification of material incorporated; form of incorporation. In each case of incorporation by reference, the matter incorporated shall be clearly identified in...

  16. High fidelity modeling of thermal relaxation and dissociation of oxygen

    NASA Astrophysics Data System (ADS)

    Andrienko, Daniil A.; Boyd, Iain D.

    2015-11-01

    A master equation study of vibrational relaxation and dissociation of oxygen is conducted using state-specific O2-O transition rates, generated by extensive trajectory simulations. Both O2-O and O2-O2 collisions are concurrently simulated in the evolving nonequilibrium gas system under constant heat bath conditions. The forced harmonic oscillator model is incorporated to simulate the state-to-state relaxation of oxygen in O2-O2 collisions. The system of master equations is solved to simulate heating and cooling flows. The present study demonstrates the importance of atom-diatom collisions due to the extremely efficient energy randomization in the intermediate O3 complex. It is shown that the presence of atomic oxygen has a significant impact on vibrational relaxation time at temperatures observed in hypersonic flow. The population of highly-excited O2 vibrational states is affected by the amount of atomic oxygen when modeling the relaxation under constant heat bath conditions. A model of coupled state-to-state vibrational relaxation and dissociation of oxygen is also discussed.

  17. High fidelity modeling of thermal relaxation and dissociation of oxygen

    SciTech Connect

    Andrienko, Daniil A. Boyd, Iain D.

    2015-11-15

    A master equation study of vibrational relaxation and dissociation of oxygen is conducted using state-specific O{sub 2}–O transition rates, generated by extensive trajectory simulations. Both O{sub 2}–O and O{sub 2}–O{sub 2} collisions are concurrently simulated in the evolving nonequilibrium gas system under constant heat bath conditions. The forced harmonic oscillator model is incorporated to simulate the state-to-state relaxation of oxygen in O{sub 2}–O{sub 2} collisions. The system of master equations is solved to simulate heating and cooling flows. The present study demonstrates the importance of atom-diatom collisions due to the extremely efficient energy randomization in the intermediate O{sub 3} complex. It is shown that the presence of atomic oxygen has a significant impact on vibrational relaxation time at temperatures observed in hypersonic flow. The population of highly-excited O{sub 2} vibrational states is affected by the amount of atomic oxygen when modeling the relaxation under constant heat bath conditions. A model of coupled state-to-state vibrational relaxation and dissociation of oxygen is also discussed.

  18. Establishing treatment fidelity in evidence-based parent training programs for externalizing disorders in children and adolescents.

    PubMed

    Garbacz, Lauren L; Brown, Dawn M; Spee, Grace A; Polo, Antonio J; Budd, Karen S

    2014-09-01

    The current review evaluates the use of treatment fidelity strategies in evidence-based parent training programs for treating externalizing disorders. We used a broad framework for evaluating treatment fidelity developed by the National Institutes of Health Treatment Fidelity Workgroup that includes the aspects of treatment design, treatment delivery, training providers, and assessment of participant receipt of treatment and enactment of treatment skills. Sixty-five articles reporting outcome trials of evidence-based parent training programs met inclusion criteria and were coded for treatment fidelity strategies. The mean adherence to fidelity strategies was .73, which was higher than two previous review studies employing this framework in the health literature. Strategies related to treatment design showed the highest mean adherence (.83), whereas training of providers and enactment of treatment skills had the lowest (.58). In light of an increasing emphasis on effectiveness and dissemination trials, the broader treatment fidelity framework as applied in this review focuses needed attention on areas often overlooked in fidelity practices, such as training providers and generalization of treatment skills. We discuss the strengths and limitations of fidelity practices in parent training studies, implications of these findings, and areas for future research.

  19. Intervention fidelity and effectiveness of a UK worksite physical activity intervention funded by the BUPA Foundation, UK.

    PubMed

    Lawton, Rebecca; Mceachan, Rosie; Jackson, Cath; West, Robert; Conner, Mark

    2015-03-01

    The main aim of this study was to test whether the effectiveness of a worksite physical activity intervention delivered in five work organizations varied as a function of intervention fidelity. We conducted a fidelity analysis as part of a large matched-pair cluster randomized controlled trial of a worksite physical activity intervention (AME for Activity). Participants (N = 1260) were employees from five organizations in the UK. The primary trial outcome was physical activity at 9 months post intervention. Adherence, exposure, quality of delivery and participant responsiveness/engagement were measured to assess fidelity. Qualitative data about the context in which the intervention was delivered were collected via focus groups, interviews and field notes. Multi-level modelling was used to provide a comparison of the effect of the intervention on increases in physical activity for worksites where intervention fidelity was good, compared with those where intervention fidelity was poor or moderate. Intervention fidelity was poor in two organizations, moderate in two organizations and good in one organization (local council). Re-analysis of the trial data comparing employees in the local council (N = 443) with employees in all other worksites (N = 611) revealed a significant effect of the intervention on physical activity levels among council employees only. These findings suggest that the measurement of fidelity and the testing of the effects of intervention fidelity on outcomes, as part of the evaluation of complex interventions, are essential to understand the context and conditions in which interventions are most effective.

  20. The Impact of Child and Family Team Composition on Wraparound Fidelity: Examining Links between Team Attendance Consistency and Functioning

    ERIC Educational Resources Information Center

    Palamaro Munsell, Eylin; Cook, James R.; Kilmer, Ryan P.; Vishnevsky, Tanya; Strompolis, Melissa

    2011-01-01

    Although a growing body of literature has examined wraparound implementation and fidelity, child and family team (CFT) members' levels of participation and the consistency of their attendance have not been systematically examined. This study explored the relationship between CFT member attendance consistency and the fidelity of wraparound team…

  1. Comparison of Intervention Fidelity between COPE TEEN and an Attention-Control Program in a Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Kelly, Stephanie A.; Oswalt, Krista; Melnyk, Bernadette Mazurek; Jacobson, Diana

    2015-01-01

    Fidelity in implementing an intervention is critical to accurately determine and interpret the effects of an intervention. It is important to monitor the manner in which the behavioral intervention is implemented (e.g. adaptations, delivery as intended and dose). Few interventions are implemented with 100% fidelity. In this study, high school…

  2. Relationship between Systems Coaching and Problem-Solving Implementation Fidelity in a Response-to-Intervention Model

    ERIC Educational Resources Information Center

    March, Amanda L.; Castillo, Jose M.; Batsche, George M.; Kincaid, Donald

    2016-01-01

    The literature on RTI has indicated that professional development and coaching are critical to facilitating problem-solving implementation with fidelity. This study examined the extent to which systems coaching related to the fidelity of problem-solving implementation in 31 schools from six districts. Schools participated in three years of a…

  3. Incorporating Argumentation through Forensic Science

    ERIC Educational Resources Information Center

    Wheeler, Lindsay B.; Maeng, Jennifer L.; Smetana, Lara K.

    2014-01-01

    This article outlines how to incorporate argumentation into a forensic science unit using a mock trial. Practical details of the mock trial include: (1) a method of scaffolding students' development of their argument for the trial, (2) a clearly outlined set of expectations for students during the planning and implementation of the mock…

  4. High-Fidelity Patient Simulators to Expose Undergraduate Students to the Clinical Relevance of Physiology Concepts

    ERIC Educational Resources Information Center

    Harris, David M.; Bellew, Christine; Cheng, Zixi J.; Cendán, Juan C.; Kibble, Jonathan D.

    2014-01-01

    The use of high-fidelity patient simulators (HFPSs) has expanded throughout medical, nursing, and allied health professions education in the last decades. These manikins can be programmed to represent pathological states and are used to teach clinical skills as well as clinical reasoning. First, the students are typically oriented either to the…

  5. Influence of sampling rate on the calculated fidelity of an aircraft simulation

    NASA Technical Reports Server (NTRS)

    Howard, J. C.

    1983-01-01

    One of the factors that influences the fidelity of an aircraft digital simulation is the sampling rate. As the sampling rate is increased, the calculated response of the discrete representation tends to coincide with the response of the corresponding continuous system. Because of computer limitations, however, the sampling rate cannot be increased indefinitely. Moreover, real-time simulation requirements demand that a finite sampling rate be adopted. In view of these restrictions, a study was undertaken to determine the influence of sampling rate on the response characteristics of a simulated aircraft describing short-period oscillations. Changes in the calculated response characteristics of the simulated aircraft degrade the fidelity of the simulation. In the present context, fidelity degradation is defined as the percentage change in those characteristics that have the greatest influence on pilot opinion: short period frequency omega, short period damping ratio zeta, and the product omega zeta. To determine the influence of the sampling period on these characteristics, the equations describing the response of a DC-8 aircraft to elevator control inputs were used. The results indicate that if the sampling period is too large, the fidelity of the simulation can be degraded.

  6. The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation.

    PubMed

    Zhao, Lei; Sun, Ming-An; Li, Zejuan; Bai, Xue; Yu, Miao; Wang, Min; Liang, Liji; Shao, Xiaojian; Arnovitz, Stephen; Wang, Qianfei; He, Chuan; Lu, Xuemei; Chen, Jianjun; Xie, Hehuang

    2014-08-01

    The faithful transmission of DNA methylation patterns through cell divisions is essential for the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment of methylation fidelity, we implemented a genome-scale hairpin bisulfite sequencing approach to generate methylation data for DNA double strands simultaneously. We show here that methylation fidelity increases globally during differentiation of mouse embryonic stem cells (mESCs), and is particularly high in the promoter regions of actively expressed genes and positively correlated with active histone modification marks and binding of transcription factors. The majority of intermediately (40%-60%) methylated CpG dinucleotides are hemi-methylated and have low methylation fidelity, particularly in the differentiating mESCs. While 5-hmC and 5-mC tend to coexist, there is no significant correlation between 5-hmC levels and methylation fidelity. Our findings may shed new light on our understanding of the origins of methylation variations and the mechanisms underlying DNA methylation transmission.

  7. Fidelity of Implementation and Instructional Alignment in Response to Intervention Research

    ERIC Educational Resources Information Center

    Hill, David R.; King, Seth A.; Lemons, Christopher J.; Partanen, Jane N.

    2012-01-01

    In this review, we explore the extent to which researchers evaluating the efficacy of Tier 2 elementary reading interventions within the framework of Response to Intervention reported on fidelity of implementation and alignment of instruction between tiers. A literature search identified 22 empirical studies from which conclusions were drawn.…

  8. Preliminary Validation of the Implementation Phases Inventory for Assessing Fidelity of Schoolwide Positive Behavior Supports

    ERIC Educational Resources Information Center

    Bradshaw, Catherine P.; Debnam, Katrina; Koth, Christine W.; Leaf, Philip

    2009-01-01

    Schoolwide positive behavioral interventions and supports (SWPBIS) are becoming increasingly popular with schools across the country to help create safer learning environments for students. An important aspect of SWPBIS is the ongoing monitoring and evaluation of implementation fidelity. Although a few measures have been created to assess the…

  9. Zero-Fidelity Simulation: Engaging Team Coordination without Physical, Functional, or Psychological Re-Creation

    NASA Technical Reports Server (NTRS)

    Toups, Zachary O.; Hamilton, William A.; Kerne, Andruid

    2012-01-01

    Team coordination is essential across domains, enabling efficiency and safety. As technology improves, our temptation is to simulate with ever-higher fidelity, by making simulators re-create reality through their physical interfaces, functionality, and by making participants believe they are undertaking the simulated task. However, high-fidelity simulations often miss salient human-human work practices. We introduce the concept of zero-fidelity simulation (ZFS), a move away from literal high-fidelity mimesis of the concrete environment. ZFS alternatively models cooperation and communication as the basis of simulation. The ZFS Team Coordination Game (TeC) is developed from observation of fire emergency response work practice. We identify ways in which team members are mutually dependent on one another for information, and use these as the basis for the ZFS game design. The design creates a need for cooperation by restricting individual activity and requiring communication. The present research analyzes the design of interdependence in the validated ZFS TeC game. We successfully simulate interdependence between roles in emergency response without simulating the concrete environment.

  10. Coaching Support, Context, and Fidelity of Implementation in "Responsive Classroom"® Schools

    ERIC Educational Resources Information Center

    Paxton, Carol L. C.; Wanless, Shannon B.; Rimm-Kaufman, Sara E.

    2013-01-01

    Research in social and emotional learning interventions confirms the importance of fidelity of implementation in predicting intervention effectiveness (Durlak, Weissberg, Dymnicki, Taylor, & Schellinger, 2011). The present mixed-methods study was conducted in the context of the Responsive Classroom Efficacy Study (RCES). This was a randomized…

  11. Developing a Fidelity of Implementation Measure for the "Responsive Classroom" Approach

    ERIC Educational Resources Information Center

    Nathanson, Lori

    2009-01-01

    This study examines the psychometric properties, reliability, and validity of a measure designed to assess fidelity of implementation of the "Responsive Classroom"[R] ("RC") approach. The Classroom Practices Teacher Survey (CPTS) assesses teachers' use of the "RC" approach, a social and emotional learning (SEL) intervention currently under…

  12. Analyzing clonal fidelity of micropropagated Psidium guajava L. plants using simple sequence repeat markers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Micropropagation of Psidium guajava L. (guava) is a viable alternative to currently adopted techniques for large-scale plant propagation of commercial cultivars. Assessment of clonal fidelity in micropropagated plants is the first step towards ensuring genetic uniformity in mass production of planti...

  13. Assessing Implementation Fidelity and Adaptation in a Community-Based Childhood Obesity Prevention Intervention

    ERIC Educational Resources Information Center

    Richards, Zoe; Kostadinov, Iordan; Jones, Michelle; Richard, Lucie; Cargo, Margaret

    2014-01-01

    Little research has assessed the fidelity, adaptation or integrity of activities implemented within community-based obesity prevention initiatives. To address this gap, a mixed-method process evaluation was undertaken in the context of the South Australian Obesity Prevention and Lifestyle (OPAL) initiative. An ecological coding procedure assessed…

  14. Teacher Agency and Professional Learning: Rethinking Fidelity of Implementation as Multiplicities of Enactment

    ERIC Educational Resources Information Center

    Buxton, Cory A.; Allexsaht-Snider, Martha; Kayumova, Shakhnoza; Aghasaleh, Rouhollah; Choi, Youn-Jeng; Cohen, Allan

    2015-01-01

    In this paper we use practice theory, with its focus on the interplay of structure and agency, to theorize about teacher engagement in professional learning and teacher enactment of pedagogical practices as an alternative to framing implementation research in terms of program adherence and fidelity of implementation. Practice theory allowed us to…

  15. Program Fidelity and Teacher Decisions: A Case Study of the Renaissance Learning Program

    ERIC Educational Resources Information Center

    Putnam, Jennifer D.

    2011-01-01

    This dissertation was designed to examine the degree to which the fidelity of implementation of the Renaissance Learning program impacts teacher instruction, as well as teacher perception of student reading motivation and achievement. The teachers at a western North Carolina elementary school used the Renaissance Learning program for over 15…

  16. The Value of Fidelity of Implementation Criteria to Evaluate School-Based Science Curriculum Innovations

    ERIC Educational Resources Information Center

    Lee, Yew-Jin; Chue, Shien

    2013-01-01

    School-based curriculum innovations, including those in science education, are usually not adequately evaluated, if at all. Furthermore, current procedures and instruments for programme evaluations are often unable to support evidence-based decision-making. We suggest that adopting fidelity of implementation (FOI) criteria from healthcare research…

  17. Validity as Process: A Construct Driven Measure of Fidelity of Implementation

    ERIC Educational Resources Information Center

    Jones, Ryan Seth

    2013-01-01

    Estimates of fidelity of implementation are essential to interpret the effects of educational interventions in randomized controlled trials (RCTs). While random assignment protects against many threats to validity, and therefore provides the best approximation to a true counterfactual condition, it does not ensure that the treatment condition…

  18. An Analysis of the Educational Value of Low-Fidelity Anatomy Models as External Representations

    ERIC Educational Resources Information Center

    Chan, Lap Ki; Cheng, Maurice M. W.

    2011-01-01

    Although high-fidelity digital models of human anatomy based on actual cross-sectional images of the human body have been developed, reports on the use of physical models in anatomy teaching continue to appear. This article aims to examine the common features shared by these physical models and analyze their educational value based on the…

  19. Teacher Fidelity to a Physical Education Curricular Model and Physical Activity Outcomes

    ERIC Educational Resources Information Center

    Stylianou, Michalis; Kloeppel, Tiffany; Kulinna, Pamela; van der Mars, Han

    2016-01-01

    Background: This study was informed by the bodies of literature emphasizing the role of physical education in promoting physical activity (PA) and addressing teacher fidelity to curricular models. Purpose: The purpose of this study was to compare student PA levels, lesson context, and teacher PA promotion behavior among classes where teachers were…

  20. Model Fidelity and Students' Responses to an Authenticated Unit of Cooperative Learning

    ERIC Educational Resources Information Center

    Casey, Ashley; Goodyear, Victoria A.; Dyson, Ben

    2015-01-01

    A wealth of school-based interventions report on students' positive responses to the use of models-based practice in physical education. However, research that examines the effectiveness of models-based practice rarely reports on the fidelity of implementation i.e. when all of the characteristics of a model are implemented. The purpose of this…

  1. A Randomized Controlled Study of Manikin Simulator Fidelity on Neonatal Resuscitation Program Learning Outcomes

    ERIC Educational Resources Information Center

    Curran, Vernon; Fleet, Lisa; White, Susan; Bessell, Clare; Deshpandey, Akhil; Drover, Anne; Hayward, Mark; Valcour, James

    2015-01-01

    The neonatal resuscitation program (NRP) has been developed to educate physicians and other health care providers about newborn resuscitation and has been shown to improve neonatal resuscitation skills. Simulation-based training is recommended as an effective modality for instructing neonatal resuscitation and both low and high-fidelity manikin…

  2. Advancements in Procedural Fidelity Assessment and Intervention: Introduction to the Special Issue

    ERIC Educational Resources Information Center

    DiGennaro Reed, Florence D.; Codding, Robin S.

    2014-01-01

    Interest in procedural fidelity has grown rapidly since 1981 as evidenced by the growing numbers of research publications across disciplines on this topic. As a result, the past 30 years of research has yielded a variety of procedures to guide research and practice, which we hope translates into better educational practices and services. Despite…

  3. The Effects of Utilizing High-Fidelity Simulation in Medical Residency Programs

    ERIC Educational Resources Information Center

    Saleta, Jennifer M.

    2012-01-01

    The purpose of this study was to examine the effects of utilizing high-fidelity simulation on the team performance, perceived level of learning, and satisfaction of resident physicians in a simulated cardiac resuscitation scenario. This study was significant because it filled a gap in the literature about how methods of education impact healthcare…

  4. Teachers Teaching Differently: A Qualitative Study of Implementation Fidelity to Professional Development

    ERIC Educational Resources Information Center

    Woolley, Michael E.; Rose, Roderick A.; Mercado, Micaela; Orthner, Dennis K.

    2013-01-01

    Intervention researchers in school settings often implement interventions that involve professional development to schoolteachers or other professional staff to implement school-based interventions. In terms of classroom interventions, teachers are the primary implementation agents; therefore, the fidelity of such interventions depends on teacher…

  5. Progress in the utilization of high-fidelity simulation in basic science education.

    PubMed

    Helyer, Richard; Dickens, Peter

    2016-06-01

    High-fidelity patient simulators are mainly used to teach clinical skills and remain underutilized in teaching basic sciences. This article summarizes our current views on the use of simulation in basic science education and identifies pitfalls and opportunities for progress.

  6. Progress in the Utilization of High-Fidelity Simulation in Basic Science Education

    ERIC Educational Resources Information Center

    Helyer, Richard; Dickens, Peter

    2016-01-01

    High-fidelity patient simulators are mainly used to teach clinical skills and remain underutilized in teaching basic sciences. This article summarizes our current views on the use of simulation in basic science education and identifies pitfalls and opportunities for progress.

  7. Evaluating the Implementation of the Empowering Coaching™ Programme: Balancing Fidelity and Adaptation

    ERIC Educational Resources Information Center

    Søvik, Margaret L.; Larsen, Torill; Tjomsland, Hege; Samdal, Oddrun

    2016-01-01

    Purpose: The purpose of this paper is to explore the implementation of a theoretically grounded coach education training programme for youth football coaches in Norway, through observational methods. In particular, it focuses on implementation fidelity and programme adaptation, and possible differences between the coach educators (CEs) according…

  8. Installing the Communities that Care Prevention System: Implementation Progress and Fidelity in a Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Quinby, Rose K.; Hanson, Koren; Brooke-Weiss, Blair; Arthur, Michael W.; Hawkins, J. David; Fagan, Abigail A.

    2008-01-01

    This article describes the degree to which high fidelity implementation of the Communities That Care (CTC) prevention operating system was reached during the first 18 months of intervention in 12 communities in the Community Youth Development Study, a 5-year group randomized controlled trial designed to test the efficacy of the CTC system. CTC…

  9. The Eeffects of Implementation Fidelity in the "Towards No Drug Abuse" Dissemination Trial

    ERIC Educational Resources Information Center

    Little, Melissa A.; Sussman, Steven; Sun, Ping; Rohrbach, Louise A.

    2013-01-01

    Purpose: The current study aims to examine the influence of contextual and provider-level factors on the implementation fidelity of a research-based substance abuse prevention program. Also, it aims to investigate whether two provider-level factors, self-efficacy and beliefs about the value of the program, statistically moderate and mediate the…

  10. Structural Basis of High-Fidelity DNA Synthesis by Yeast DNA Polymerase δ

    SciTech Connect

    Swan, M.; Johnson, R; Prakash, L; Prakash, S; Aggarwal, A

    2009-01-01

    DNA polymerase ? (Pol ?) has a crucial role in eukaryotic replication. Now the crystal structure of the yeast DNA Pol ? catalytic subunit in complex with template primer and incoming nucleotide is presented at 2.0-A resolution, providing insight into its high fidelity and a framework to understand the effects of mutations involved in tumorigenesis.

  11. A Systematic Review of Fidelity of Implementation in Parent-Mediated Early Communication Intervention

    ERIC Educational Resources Information Center

    Lieberman-Betz, Rebecca G.

    2015-01-01

    This article examined the reporting of four elements of fidelity of implementation (FOI) in parent-mediated early communication treatment studies. Thirty-five studies were reviewed to extract information regarding reporting of dosage, adherence, quality, and participant responsiveness for both practitioners and parents involved in parent-delivered…

  12. High-Fidelity Simulation Meets Athletic Training Education: An Innovative Collaborative Teaching Project

    ERIC Educational Resources Information Center

    Palmer, Elizabeth; Edwards, Taylor; Racchini, James

    2014-01-01

    High-fidelity simulation is frequently used in nursing education to provide students with simulated experiences prior to and throughout clinical coursework that involves direct patient care. These high-tech exercises take advantage of the benefits of a standardized patient or mock patient encounter, while eliminating some of the drawbacks…

  13. Information Processing, Specificity of Practice, and the Transfer of Learning: Considerations for Reconsidering Fidelity

    ERIC Educational Resources Information Center

    Grierson, Lawrence E. M.

    2014-01-01

    Much has been made in the recent medical education literature of the incorrect characterization of simulation along a continuum of low to high fidelity (Cook et al. "JAMA" 306(9): 978-988, 2011; Norman et al. "Med Educ" 46(7): 636-647, 2012; Teteris et al. "Adv Health Sci Educ" 17(1): 137-144, 2012). For the most…

  14. High fidelity, low cost moulage as a valid simulation tool to improve burns education.

    PubMed

    Pywell, M J; Evgeniou, E; Highway, K; Pitt, E; Estela, C M

    2016-06-01

    Simulation allows the opportunity for repeated practice in controlled, safe conditions. Moulage uses materials such as makeup to simulate clinical presentations. Moulage fidelity can be assessed by face validity (realism) and content validity (appropriateness). The aim of this project is to compare the fidelity of professional moulage to non-professional moulage in the context of a burns management course. Four actors were randomly assigned to a professional make-up artist or a course faculty member for moulage preparation such that two actors were in each group. Participants completed the actor-based burn management scenarios and answered a ten-question Likert-scale questionnaire on face and content validity. Mean scores and a linear mixed effects model were used to compare professional and non-professional moulage. Cronbach's alpha assessed internal consistency. Twenty participants experienced three out of four scenarios and at the end of the course completed a total of 60 questionnaires. Professional moulage had higher average ratings for face (4.30 v 3.80; p=0.11) and content (4.30 v 4.00; p=0.06) validity. Internal consistency of face (α=0.91) and content (α=0.85) validity questions was very good. The fidelity of professionally prepared moulage, as assessed by content validity, was higher than non-professionally prepared moulage. We have shown that using professional techniques and low cost materials we can prepare quality high fidelity moulage simulations.

  15. Treatment Fidelity: Its Importance and Reported Frequency in Aphasia Treatment Studies

    ERIC Educational Resources Information Center

    Hinckley, Jacqueline J.; Douglas, Natalie F.

    2013-01-01

    Purpose: Treatment fidelity is a measure of the reliability of the administration of an intervention in a treatment study. It is an important aspect of the validity of a research study, and it has implications for the ultimate implementation of evidence-supported interventions in typical clinical settings. Method: Aphasia treatment studies…

  16. High fidelity quantum state transfer in electromechanical systems with intermediate coupling.

    PubMed

    Zhou, Jian; Hu, Yong; Yin, Zhang-qi; Wang, Z D; Zhu, Shi-Liang; Xue, Zheng-Yuan

    2014-08-29

    Hybrid quantum systems usually consist of two or more subsystems, which may take the advantages of the different systems. Recently, the hybrid system consisting of circuit electromechanical subsystems have attracted great attention due to its advanced fabrication and scalable integrated photonic circuit techniques. Here, we propose a scheme for high fidelity quantum state transfer between a superconducting qubit and a nitrogen-vacancy center in diamond, which are coupled to a superconducting transmission-line resonator with coupling strength g1 and a nanomechanical resonator with coupling strength g2, respectively. Meanwhile, the two resonators are parametrically coupled with coupling strength J. The system dynamics, including the decoherence effects, is numerical investigated. It is found that both the small (J<{g1,g2}) and large (J>{g1,g2}) coupling regimes of this hybrid system can not support high fidelity quantum state transfer before significant technique advances. However, in the intermediate coupling regime (J ~ g1 ~ g2), in contrast to a conventional wisdom, high fidelity quantum information transfer can be implemented, providing a promising route towards high fidelity quantum state transfer in similar coupled resonators systems.

  17. In-Group Ostracism Increases High-Fidelity Imitation in Early Childhood.

    PubMed

    Watson-Jones, Rachel E; Whitehouse, Harvey; Legare, Cristine H

    2016-01-01

    The Cyberball paradigm was used to examine the hypothesis that children use high-fidelity imitation as a reinclusion behavior in response to being ostracized by in-group members. Children (N = 176; 5- to 6-year-olds) were either included or excluded by in- or out-group members and then shown a video of an in-group or an out-group member enacting a social convention. Participants who were excluded by their in-group engaged in higher-fidelity imitation than those who were included by their in-group. Children who were included by an out-group and those who were excluded by an out-group showed no difference in imitative fidelity. Children ostracized by in-group members also displayed increased anxiety relative to children ostracized by out-group members. The data are consistent with the proposal that high-fidelity imitation functions as reinclusion behavior in the context of in-group ostracism.

  18. Designing High Fidelity Simulation to Maximize Student Registered Nursing Decision-Making Ability

    ERIC Educational Resources Information Center

    Deckers, Cathleen

    2011-01-01

    The current healthcare environment is a complex system of patients, procedures, and equipment that strives to deliver safe and effective medical care. High fidelity simulation provides healthcare educators with a tool to create safety conscious practitioners utilizing an environment that replicates practice without risk to patients. Using HFS…

  19. The Youth Self-Report Inventory: A Study of Its Measurement Fidelity.

    ERIC Educational Resources Information Center

    Song, Li-yu; And Others

    1994-01-01

    Measurement fidelity (reliability, factor structure, and validity) of Aschenbach's Youth Self-Report scale was studied with 226 adolescents at a psychiatric hospital. Findings confirm convergent validity and reliability of four of the measure's seven narrowband syndromes, and seven meaningful subdimensions were extracted from the other three…

  20. Within-Year Fidelity Growth of SWPBIS during Installation and Initial Implementation

    ERIC Educational Resources Information Center

    Schaper, Andrew; McIntosh, Kent; Hoselton, Robert

    2016-01-01

    The purpose of this study was to document within-year fidelity growth during installation and initial implementation of School-Wide Positive Behavioral Interventions and Supports (SWPBIS). Participants included school teams from schools throughout the United States that were in years one to four of SWPBIS implementation and routinely evaluated…

  1. Within-Year Fidelity Growth of SWPBIS during Installation and Initial Implementation

    ERIC Educational Resources Information Center

    Schaper, Andrew; McIntosh, Kent; Hoselton, Robert

    2016-01-01

    The purpose of this study was to document within-year fidelity growth during installation and initial implementation of School-Wide Positive Behavioral Interventions and Supports (SWPBIS). Participants included school teams from schools throughout the United States that were in years 1 to 4 of SWPBIS implementation and routinely evaluated their…

  2. Three-year trajectory of teachers' fidelity to a drug prevention curriculum.

    PubMed

    Ringwalt, Christopher L; Pankratz, Melinda M; Jackson-Newsom, Julia; Gottfredson, Nisha C; Hansen, William B; Giles, Steven M; Dusenbury, Linda

    2010-03-01

    Little is known about the trajectories over time of classroom teachers' fidelity to drug prevention curricula. Using the "Concerns-Based Adoption Model" (C-BAM) as a theoretical framework, we hypothesized that teachers' fidelity would improve with repetition. Participants comprised 23 middle school teachers who videotaped their administration of three entire iterations of the All Stars curriculum. Investigators coded two key curriculum lessons, specifically assessing the proportion of activities of each lesson teachers attempted and whether they omitted, added, or changed prescribed content, or delivered it using new methods. Study findings provided only partial support for the C-BAM model. Considerable variability in teachers' performance over time was noted, suggesting that their progression over time may be nonlinear and dynamic, and quite possibly a function of their classroom and school contexts. There was also evidence that, by their third iteration of All Stars, teachers tended to regress toward the baseline mean. That is, the implementation quality of those that started out with high levels of fidelity tended to degrade, while those that started out with very low fidelity to the curriculum tended to improve. Study findings suggest the need for ongoing training and technical assistance, as well as "just in time" messages delivered electronically; but it is also possible that some prevention curricula may impose unrealistic expectations or burdens on teachers' abilities and classroom time.

  3. Debriefing after High-Fidelity Simulation and Knowledge Retention: A Quasi-Experimental Study

    ERIC Educational Resources Information Center

    Olson, Susan L.

    2013-01-01

    High-fidelity simulation (HFS) use in nursing education has been a frequent research topic in recent years. Previous research included studies on the use of HFS with nursing students, focusing on their feelings of self-confidence and anxiety. However, research focused specifically on the debriefing portion of HFS was limited. This quantitative,…

  4. Treatment Fidelity of Motivational Interviewing Delivered by a School Nurse to Increase Girls' Physical Activity

    ERIC Educational Resources Information Center

    Robbins, Lorraine B.; Pfeiffer, Karin A.; Maier, Kimberly S.; LaDrig, Stacey M.; Berg-Smith, Steven Malcolm

    2012-01-01

    Motivational interviewing, which involves the use of person-centered, directive counseling techniques, shows promise for changing adolescent behaviors. The purpose of this article was to describe the methodology and findings related to the treatment fidelity of three face-to-face motivational interviewing sessions involving middle school girls and…

  5. Implementation Fidelity in a Teacher-Led Alcohol Use Prevention Curriculum

    ERIC Educational Resources Information Center

    Pankratz, Melinda M.; Jackson-Newsom, Julia; Giles, Steven M.; Ringwalt, Christopher L.; Bliss, Kappie; Bell, Mary Lou

    2006-01-01

    There is now ample evidence that teachers tend to make substantial modifications to both the prescribed content and methods of the curricula they administer, and that such modifications are likely to attenuate curricula effects. We examine the fidelity with which teachers implement "Protecting You, Protecting Me," an underage alcohol use…

  6. Fidelity of Problem-Solving Implementation and Relationship to Student Performance.

    ERIC Educational Resources Information Center

    Telzrow, Cathy F.; McNamara, Kathy; Hollinger, Constance L.

    2000-01-01

    Examines the fidelity of problem-solving implementation by multidisciplinary teams (MDTs) in 227 schools and the relationship to student outcomes. Ratings of student goal attainment indicated positive student change during problem-solving implementation. Statistically significant but modest correlation coefficients were demonstrated between…

  7. Program Fidelity in Two "Reading Mastery" Classrooms: A View from the Inside

    ERIC Educational Resources Information Center

    Shelton, Nancy Rankie

    2010-01-01

    This article reports research that examines the impact of fidelity to a scripted program in two third-grade classrooms. The data was drawn from a study conducted in an elementary school functioning under pressure from state and district policy to increase student standardized reading test scores. Thematic analysis was used to analyze observation…

  8. Intervention Fidelity for a Complex Behaviour Change Intervention in Community Pharmacy Addressing Cardiovascular Disease Risk

    ERIC Educational Resources Information Center

    McNamara, K. P.; O'Reilly, S. L.; George, J.; Peterson, G. M.; Jackson, S. L.; Duncan, G.; Howarth, H.; Dunbar, J. A.

    2015-01-01

    Background: Delivery of cardiovascular disease (CVD) prevention programs by community pharmacists appears effective and enhances health service access. However, their capacity to implement complex behavioural change processes during patient counselling remains largely unexplored. This study aims to determine intervention fidelity by pharmacists…

  9. A Coupled-Adjoint Method for High-Fidelity Aero-Structural Optimization

    DTIC Science & Technology

    2002-10-01

    geometry engine, and an efficient gradient-based optimization algorithm. The aero-structural solver ensures accurate solutions by using high-fidelity...22 2.3.1 Geometry Engine and Database . . . . . . . . . . . . . . . . . . . . . 23 2.3.2 Displacement Transfer...86 5-6 Airfoil geometry at the root. . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 5-7 Airfoil geometry at mid semi-span

  10. Genetic fidelity and variability of micropropagated cassava plants (Manihot esculenta Crantz) evaluated using ISSR markers.

    PubMed

    Vidal, Á M; Vieira, L J; Ferreira, C F; Souza, F V D; Souza, A S; Ledo, C A S

    2015-07-14

    Molecular markers are efficient for assessing the genetic fidelity of various species of plants after in vitro culture. In this study, we evaluated the genetic fidelity and variability of micropropagated cassava plants (Manihot esculenta Crantz) using inter-simple sequence repeat markers. Twenty-two cassava accessions from the Embrapa Cassava & Fruits Germplasm Bank were used. For each accession, DNA was extracted from a plant maintained in the field and from 3 plants grown in vitro. For DNA amplification, 27 inter-simple sequence repeat primers were used, of which 24 generated 175 bands; 100 of those bands were polymorphic and were used to study genetic variability among accessions of cassava plants maintained in the field. Based on the genetic distance matrix calculated using the arithmetic complement of the Jaccard's index, genotypes were clustered using the unweighted pair group method using arithmetic averages. The number of bands per primer was 2-13, with an average of 7.3. For most micropropagated accessions, the fidelity study showed no genetic variation between plants of the same accessions maintained in the field and those maintained in vitro, confirming the high genetic fidelity of the micropropagated plants. However, genetic variability was observed among different accessions grown in the field, and clustering based on the dissimilarity matrix revealed 7 groups. Inter-simple sequence repeat markers were efficient for detecting the genetic homogeneity of cassava plants derived from meristem culture, demonstrating the reliability of this propagation system.

  11. Developing High-Fidelity Health Care Simulation Scenarios: A Guide for Educators and Professionals

    ERIC Educational Resources Information Center

    Alinier, Guillaume

    2011-01-01

    The development of appropriate scenarios is critical in high-fidelity simulation training. They need to be developed to address specific learning objectives, while not preventing other learning points from emerging. Buying a patient simulator, finding a volunteer to act as the patient, or even obtaining ready-made scenarios from another simulation…

  12. Measuring Fidelity and Adaptation: Reliability of a Instrument for School-Based Prevention Programs.

    PubMed

    Bishop, Dana C; Pankratz, Melinda M; Hansen, William B; Albritton, Jordan; Albritton, Lauren; Strack, Joann

    2014-06-01

    There is a need to standardize methods for assessing fidelity and adaptation. Such standardization would allow program implementation to be examined in a manner that will be useful for understanding the moderating role of fidelity in dissemination research. This article describes a method for collecting data about fidelity of implementation for school-based prevention programs, including measures of adherence, quality of delivery, dosage, participant engagement, and adaptation. We report about the reliability of these methods when applied by four observers who coded video recordings of teachers delivering All Stars, a middle school drug prevention program. Interrater agreement for scaled items was assessed for an instrument designed to evaluate program fidelity. Results indicated sound interrater reliability for items assessing adherence, dosage, quality of teaching, teacher understanding of concepts, and program adaptations. The interrater reliability for items assessing potential program effectiveness, classroom management, achievement of activity objectives, and adaptation valences was improved by dichotomizing the response options for these items. The item that assessed student engagement demonstrated only modest interrater reliability and was not improved through dichotomization. Several coder pairs were discordant on items that overall demonstrated good interrater reliability. Proposed modifications to the coding manual and protocol are discussed.

  13. Becoming a High-Fidelity--"Super"--Imitator: What Are the Contributions of Social and Individual Learning?

    ERIC Educational Resources Information Center

    Subiaul, Francys; Patterson, Eric M.; Schilder, Brian; Renner, Elizabeth; Barr, Rachel

    2015-01-01

    In contrast to other primates, human children's imitation performance goes from low to high fidelity soon after infancy. Are such changes associated with the development of other forms of learning? We addressed this question by testing 215 children (26-59 months) on two social conditions (imitation, emulation)--involving a demonstration--and two…

  14. Measuring the Implementation Fidelity of Student Affairs Programs: A Critical Component of the Outcomes Assessment Cycle

    ERIC Educational Resources Information Center

    Gerstner, Jerusha J.; Finney, Sara J.

    2013-01-01

    Implementation fidelity assessment provides a means of measuring the alignment between the planned program and the implemented program. Unfortunately, the implemented program can differ from the planned program, resulting in ambiguous inferences about the planned program's effectiveness (i.e., it is uncertain if poor results are due to an…

  15. Evidence for wing molt and breeding site fidelity in King Eiders

    USGS Publications Warehouse

    Phillips, Laura M.; Powell, A.N.

    2006-01-01

    Fidelity of King Eiders (Somateria spectabilis) to breeding and wing molt sites was examined using satellite telemetry data obtained opportunistically when battery life of transmitters provided locations in a second year. Consecutive breeding locations were obtained for eleven female and 23 male King Eiders. All females exhibited breeding site fidelity by returning to sites within 15 km of first year breeding areas on the North Slope of Alaska. Breeding locations of males in a subsequent year were located on average >1000 km from their prior breeding sites and were primarily outside Alaska, on the coasts of Russia and Canada. Second-year wing molt locations were obtained for two female and six male King Eiders. Wing molt sites of males were located 6.2 ?? 3.1 km apart on average in successive years, while female wing molt locations averaged almost 50 km apart. Our results demonstrate site fidelity of female King Eiders to a breeding area on the North Slope of Alaska, document the dispersal of male King Eiders between breeding seasons, and present the first evidence for wing molt site fidelity in males.

  16. Device-Task Fidelity and Transfer of Training: Aircraft Cockpit Procedures Training.

    ERIC Educational Resources Information Center

    Prophet, Wallace W.; Boyd, H. Alton

    An evaluation was made of the training effectiveness of two cockpit procedures training devices, differing greatly in physical fidelity and cost, for use on the ground for a twin-engine, turboprop, fixed-wing aircraft. One group of students received training in cockpit procedures in a relatively expensive, sophisticated, computerized trainer,…

  17. An Assessment of Intervention Fidelity in Published Social Work Intervention Research Studies

    ERIC Educational Resources Information Center

    Corley, Nicole A.; Kim, Irang

    2016-01-01

    Objectives: Intervention fidelity is a critical strategy to help advance the usefulness and integrity of social work research. This study assessed the extent to which a selected sample of published social work intervention researchers reported its intervention protocols. Methods: Six core social work journals were reviewed in this analysis. The…

  18. High-fidelity simulation in the nonmedical domain: practices and potential transferable competencies for the medical field

    PubMed Central

    Carron, Pierre-Nicolas; Trueb, Lionel; Yersin, Bertrand

    2011-01-01

    Simulation is a promising pedagogical tool in the area of medical education. High- fidelity simulators can reproduce realistic environments or clinical situations. This allows for the practice of teamwork and communication skills, thereby enhancing reflective reasoning and experiential learning. Use of high-fidelity simulators is not limited to the medical and aeronautical fields, but has developed in a large number of nonmedical organizations as well. The techniques and pedagogical tools which have evolved through the use of nonmedical simulations serve not only as teaching examples but also as avenues which can help further the evolution of the concept of high-fidelity simulation in the field of medicine. This paper presents examples of high-fidelity simulations in the military, maritime, and aeronautical fields. We compare the implementation of high-fidelity simulation in the medical and nonmedical domains, and discuss the possibilities and limitations of simulators in medicine, based on recent nonmedical applications. PMID:23745086

  19. An Investigation of the Impact of Aerodynamic Model Fidelity on Close-In Combat Effectiveness Prediction in Piloted Simulation

    NASA Technical Reports Server (NTRS)

    Persing, T. Ray; Bellish, Christine A.; Brandon, Jay; Kenney, P. Sean; Carzoo, Susan; Buttrill, Catherine; Guenther, Arlene

    2005-01-01

    Several aircraft airframe modeling approaches are currently being used in the DoD community for acquisition, threat evaluation, training, and other purposes. To date there has been no clear empirical study of the impact of airframe simulation fidelity on piloted real-time aircraft simulation study results, or when use of a particular level of fidelity is indicated. This paper documents a series of piloted simulation studies using three different levels of airframe model fidelity. This study was conducted using the NASA Langley Differential Maneuvering Simulator. Evaluations were conducted with three pilots for scenarios requiring extensive maneuvering of the airplanes during air combat. In many cases, a low-fidelity modified point-mass model may be sufficient to evaluate the combat effectiveness of the aircraft. However, in cases where high angle-of-attack flying qualities and aerodynamic performance are a factor or when precision tracking ability of the aircraft must be represented, use of high-fidelity models is indicated.

  20. Error propagation and metamodeling for a fidelity tradeoff capability in complex systems design

    NASA Astrophysics Data System (ADS)

    McDonald, Robert A.

    Complex man-made systems are ubiquitous in modern technological society. The national air transportation infrastructure and the aircraft that operate within it, the highways stretching coast-to-coast and the vehicles that travel on them, and global communications networks and the computers that make them possible are all complex systems. It is impossible to fully validate a systems analysis or a design process. Systems are too large, complex, and expensive to build test and validation articles. Furthermore, the operating conditions throughout the life cycle of a system are impossible to predict and control for a validation experiment. Error is introduced at every point in a complex systems design process. Every error source propagates through the complex system in the same way information propagates, feedforward, feedback, and coupling are all present with error. As with error propagation through a single analysis, error sources grow and decay when propagated through a complex system. These behaviors are made more complex by the complex interactions of a complete system. This complication and the loss of intuition that accompanies it makes proper error propagation calculations even more important to aid the decision maker. Error allocation and fidelity trade decisions answer questions like: Is the fidelity of a complex systems analysis adequate, or is an improvement needed? If an improvement is needed, how is that improvement best achieved? Where should limited resources be invested for the improvement of fidelity? How does knowledge of the imperfection of a model impact design decisions based on the model and the certainty of the performance of a particular design? In this research, a fidelity trade environment was conceived, formulated, developed, and demonstrated. This development relied on the advancement of enabling techniques including error propagation, metamodeling, and information management. A notional transport aircraft is modeled in the fidelity trade

  1. Mate fidelity and breeding site tenacity in a monogamous sandpiper, the black turnstone

    USGS Publications Warehouse

    Handel, C.M.; Gill, R.E.

    2000-01-01

    We examined the relationship between mate fidelity and breeding site tenacity during a 5-year study of the black turnstone, Arenaria melanocephala, a socially monogamous sandpiper breeding in subarctic Alaska. We tested the predictions of several hypotheses regarding the incidence of divorce and the benefits of fidelity to mate and breeding site. Interannual return rates to the breeding grounds (88% for males, 79% for females) were among the highest yet recorded for any scolopacid sandpiper, and 88% of returning birds nested on their previous year's territory. The annual divorce rate was only 11%, and mate fidelity was significantly linked to fidelity to territory but independent of sex and year. Males arrived in spring significantly earlier than their mates and interannual fidelity was influenced by the relative timing of arrival of pair members. Reunited pairs had significantly higher fledging success than new pairs formed after death or divorce. The incidence of divorce was unrelated to reproductive success the previous year, although birds nested significantly further away after failure than after a successful nesting attempt. Sightings of marked individuals suggested that members of pairs do not winter together, and breeding site tenacity provides a mechanism through which pair members can reunite. We reject the 'incompatibility' hypothesis for divorce in turnstones, and our data contradict predictions of the 'better option' hypothesis. Alternatively, we propose the 'bet-hedging' hypothesis to explain the occurrence of divorce, which transpires when an individual pairs with a new mate to avoid the cost of waiting for a previous mate to return. Such costs can include remaining unmated, if the former mate has died, or experiencing lower reproductive success because of delayed breeding.

  2. Selenium incorporation using recombinant techniques.

    PubMed

    Walden, Helen

    2010-04-01

    Using selenomethionine to phase macromolecular structures is common practice in structure determination, along with the use of selenocysteine. Selenium is consequently the most commonly used heavy atom for MAD. In addition to the well established recombinant techniques for the incorporation of selenium in prokaryal expression systems, there have been recent advances in selenium labelling in eukaryal expression, which will be discussed. Tips and things to consider for the purification and crystallization of seleno-labelled proteins are also included.

  3. Aerodynamic design applying automatic differentiation and using robust variable fidelity optimization

    NASA Astrophysics Data System (ADS)

    Takemiya, Tetsushi

    In modern aerospace engineering, the physics-based computational design method is becoming more important, as it is more efficient than experiments and because it is more suitable in designing new types of aircraft (e.g., unmanned aerial vehicles or supersonic business jets) than the conventional design method, which heavily relies on historical data. To enhance the reliability of the physics-based computational design method, researchers have made tremendous efforts to improve the fidelity of models. However, high-fidelity models require longer computational time, so the advantage of efficiency is partially lost. This problem has been overcome with the development of variable fidelity optimization (VFO). In VFO, different fidelity models are simultaneously employed in order to improve the speed and the accuracy of convergence in an optimization process. Among the various types of VFO methods, one of the most promising methods is the approximation management framework (AMF). In the AMF, objective and constraint functions of a low-fidelity model are scaled at a design point so that the scaled functions, which are referred to as "surrogate functions," match those of a high-fidelity model. Since scaling functions and the low-fidelity model constitutes surrogate functions, evaluating the surrogate functions is faster than evaluating the high-fidelity model. Therefore, in the optimization process, in which gradient-based optimization is implemented and thus many function calls are required, the surrogate functions are used instead of the high-fidelity model to obtain a new design point. The best feature of the AMF is that it may converge to a local optimum of the high-fidelity model in much less computational time than the high-fidelity model. However, through literature surveys and implementations of the AMF, the author xx found that (1) the AMF is very vulnerable when the computational analysis models have numerical noise, which is very common in high-fidelity models

  4. Incorporating Handling Qualities Analysis into Rotorcraft Conceptual Design

    NASA Technical Reports Server (NTRS)

    Lawrence, Ben

    2014-01-01

    This paper describes the initial development of a framework to incorporate handling qualities analyses into a rotorcraft conceptual design process. In particular, the paper describes how rotorcraft conceptual design level data can be used to generate flight dynamics models for handling qualities analyses. Also, methods are described that couple a basic stability augmentation system to the rotorcraft flight dynamics model to extend analysis to beyond that of the bare airframe. A methodology for calculating the handling qualities characteristics of the flight dynamics models and for comparing the results to ADS-33E criteria is described. Preliminary results from the application of the handling qualities analysis for variations in key rotorcraft design parameters of main rotor radius, blade chord, hub stiffness and flap moment of inertia are shown. Varying relationships, with counteracting trends for different handling qualities criteria and different flight speeds are exhibited, with the action of the control system playing a complex part in the outcomes. Overall, the paper demonstrates how a broad array of technical issues across flight dynamics stability and control, simulation and modeling, control law design and handling qualities testing and evaluation had to be confronted to implement even a moderately comprehensive handling qualities analysis of relatively low fidelity models. A key outstanding issue is to how to 'close the loop' with an overall design process, and options for the exploration of how to feedback handling qualities results to a conceptual design process are proposed for future work.

  5. Female mate fidelity in a Lek mating system and its implications for the evolution of cooperative lekking behavior.

    PubMed

    DuVal, E H

    2013-02-01

    The extent and importance of female mate fidelity in polygynous mating systems are poorly known. Fidelity may contribute to high variance in male reproductive success when it favors attractive mates or may stabilize social interactions if females are faithful to mating sites rather than males. Using 12 years of data on genetic mate choice in the cooperatively lekking lance-tailed manakin (Chiroxiphia lanceolata), I investigated the frequency of fidelity within and between years, whether females were faithful to individual males or to mating sites across years, and whether fidelity favored attractive males. Mate fidelity occurred in 41.7% of 120 between-year comparisons and was observed for 41.1% of 73 individual females that had the opportunity to mate faithfully. Females were not more likely to mate at prior mating sites when previous mates were replaced. Faithful females mated with the same male in up to four consecutive years but were not disproportionately faithful to attractive partners. Mating history influences current mate choice, and fidelity in this lekking system apparently represents active mate choice by females but little is not cited in the text. Please provide a citation or mark this reference for deletion.consensus in mate choices among faithful females. This study underscores the prevalence of mate fidelity in polygynous mating systems and emphasizes the need to consider the larger context of lifetime reproductive behavior when interpreting patterns of female choice.

  6. Bison distribution under conflicting foraging strategies: site fidelity vs. energy maximization.

    PubMed

    Merkle, Jerod A; Cherry, Seth G; Fortin, Daniel

    2015-07-01

    Foraging strategies based on site fidelity and maximization of energy intake rate are two adaptive forces shaping animal behavior. Whereas these strategies can both be evolutionarily stable, they predict conflicting optimal behaviors when population abundance is in decline. In such a case, foragers employing an energy-maximizing strategy should reduce their use of low-quality patches as interference competition becomes less intense for high-quality patches. Foragers using a site fidelity strategy, however, should continue to use familiar patches. Because natural fluctuations in population abundance provide the only non-manipulative opportunity to evaluate adaptation to these evolutionary forces, few studies have examined these foraging strategies simultaneously. Using abundance and space use data from a free-ranging bison (Bison bison) population living in a meadow-forest matrix in Prince Albert National Park, Canada, we determined how individuals balance the trade-off between site fidelity and energy-maximizing patch choice strategies with respect to changes in population abundance. From 1996 to 2005, bison abundance increased from 225 to 475 and then decreased to 225 by 2013. During the period of population increase, population range size increased. This expansion involved the addition of relatively less profitable areas and patches, leading to a decrease in the mean expected profitability of the range. Yet, during the period of population decline, we detected neither a subsequent retraction in population range size nor an increase in mean expected profitability of the range. Further, patch selection models. during the population decline indicated that, as density decreased, bison portrayed stronger fidelity to previously visited meadows, but no increase in selection strength for profitable meadows. Our analysis reveals that an energy-maximizing patch choice strategy alone cannot explain the distribution ofindividuals and populations, and site fidelity is an

  7. High-fidelity superadiabatic population transfer of a two-level system with a linearly chirped Gaussian pulse

    NASA Astrophysics Data System (ADS)

    Dou, Fu-quan; Liu, Jie; Fu, Li-bin

    2016-12-01

    We investigate high-fidelity superadiabatic quantum driving in a chirped Gaussian two-level model with a Gaussian temporal envelope and a linear detuning. We show that the nonadiabatic losses can be canceled to any desired order by constructing and adjusting an auxiliary Hamiltonian (counter-diabatic field) and a symmetry in the fidelity arises on the counter-diabatic field ratio. A high-fidelity, robust, and accelerated (in a shorter time) transitionless superadiabatic population transfer is achieved that ensures a perfect following of the instantaneous adiabatic ground state even in the nonadiabatic regime. The features make the superadiabatic protocol a potentially important tool for quantum information.

  8. Incorporating Spirituality in Primary Care.

    PubMed

    Isaac, Kathleen S; Hay, Jennifer L; Lubetkin, Erica I

    2016-06-01

    Addressing cultural competency in health care involves recognizing the diverse characteristics of the patient population and understanding how they impact patient care. Spirituality is an aspect of cultural identity that has become increasingly recognized for its potential to impact health behaviors and healthcare decision-making. We consider the complex relationship between spirituality and health, exploring the role of spirituality in primary care, and consider the inclusion of spirituality in existing models of health promotion. We discuss the feasibility of incorporating spirituality into clinical practice, offering suggestions for physicians.

  9. Incorporation of additives into polymers

    DOEpatents

    McCleskey, T. Mark; Yates, Matthew Z.

    2003-07-29

    There has been invented a method for incorporating additives into polymers comprising: (a) forming an aqueous or alcohol-based colloidal system of the polymer; (b) emulsifying the colloidal system with a compressed fluid; and (c) contacting the colloidal polymer with the additive in the presence of the compressed fluid. The colloidal polymer can be contacted with the additive by having the additive in the compressed fluid used for emulsification or by adding the additive to the colloidal system before or after emulsification with the compressed fluid. The invention process can be carried out either as a batch process or as a continuous on-line process.

  10. Model Fidelity Study of Dynamic Transient Loads in a Wind Turbine Gearbox: Preprint

    SciTech Connect

    Guo, Y.; Keller, J.; Moan, T.; Xing, Y.

    2013-04-01

    Transient events cause high loads in the drivetrain components so measuring and calculating these loads can improve confidence in drivetrain design. This paper studies the Gearbox Reliability Collaborative 750kW wind turbine gearbox response during transient events using a combined experimental and modeling approach. The transient events include emergency shut-downs and start-ups measured during a field testing period in 2009. The drivetrain model is established in the multibody simulation tool Simpack. A detailed study of modeling fidelity required for accurate load prediction is performed and results are compared against measured loads. A high fidelity model that includes shaft and housing flexibility and accurate bearing stiffnesses is important for the higher-speed stage bearing loads. Each of the transient events has different modeling requirements.

  11. Electrophoretic chip for high-fidelity fractionation of double-stranded DNA.

    PubMed

    Sun, Kai; Li, Zheyu; Ueno, Kosei; Juodkazis, Saulius; Noji, Sumihare; Misawa, Hiroaki

    2007-05-01

    We report the high fidelity, on-chip fractionation of selected segments from an electrophoretic flow of separated fragments. dsDNA fragments (10-330 base pairs (bp)) were initially separated using a 6.5 cm long channel with an electric field strength of 150 V/cm. As an example of the fractionation process, a target fragment of 20 bp was selected and extracted from the separation channel. The extraction was confirmed and evaluated by fluorescence imaging. High resolution and extraction fidelity were achieved by introducing new procedures for (i) extraction channel-blocking and (ii) segment transfer with cleaning. These procedures are necessary for the development of a practical, fully automated multitarget fractionation electrophoretic chip. A kind of CCD image processing method was introduced to monitor, control, and evaluate the procedure of fractionation. The resolution limits of the separation and extraction are discussed.

  12. Producing high fidelity single photons with optimal brightness via waveguided parametric down-conversion.

    PubMed

    Laiho, K; Cassemiro, K N; Silberhorn, Ch

    2009-12-07

    Parametric down-conversion (PDC) offers the possibility to control the fabrication of non-Gaussian states such as Fock states. However, in conventional PDC sources energy and momentum conservation introduce strict frequency and photon number correlations, which impact the fidelity of the prepared state. In our work we optimize the preparation of single-photon Fock states from the emission of waveguided PDC via spectral filtering. We study the effect of correlations via photon number resolving detection and quantum interference. Our measurements show how the reduction of mixedness due to filtering can be evaluated. Interfering the prepared photon with a coherent state we establish an experimentally measured fidelity of the produced target state of 78%.

  13. Detecting phase transitions and crossovers in Hubbard models using the fidelity susceptibility

    NASA Astrophysics Data System (ADS)

    Huang, Li; Wang, Yilin; Wang, Lei; Werner, Philipp

    2016-12-01

    A generalized version of the fidelity susceptibility of single-band and multiorbital Hubbard models is systematically studied using single-site dynamical mean-field theory in combination with a hybridization expansion continuous-time quantum Monte Carlo impurity solver. We find that the fidelity susceptibility is extremely sensitive to changes in the state of the system. It can be used as a numerically inexpensive tool to detect and characterize a broad range of phase transitions and crossovers in Hubbard models, including (orbital-selective) Mott metal-insulator transitions, magnetic phase transitions, high-spin to low-spin transitions, Fermi-liquid to non-Fermi-liquid crossovers, and spin-freezing crossovers.

  14. Terascale High-Fidelity Simulations of Turbulent Combustion with Detailed Chemistry: Spray Simulations

    SciTech Connect

    Rutland, Christopher J.

    2009-04-26

    The Terascale High-Fidelity Simulations of Turbulent Combustion (TSTC) project is a multi-university collaborative effort to develop a high-fidelity turbulent reacting flow simulation capability utilizing terascale, massively parallel computer technology. The main paradigm of the approach is direct numerical simulation (DNS) featuring the highest temporal and spatial accuracy, allowing quantitative observations of the fine-scale physics found in turbulent reacting flows as well as providing a useful tool for development of sub-models needed in device-level simulations. Under this component of the TSTC program the simulation code named S3D, developed and shared with coworkers at Sandia National Laboratories, has been enhanced with new numerical algorithms and physical models to provide predictive capabilities for turbulent liquid fuel spray dynamics. Major accomplishments include improved fundamental understanding of mixing and auto-ignition in multi-phase turbulent reactant mixtures and turbulent fuel injection spray jets.

  15. Tunable multi-qubit quantum phase gates with high fidelity based on graphene wrapped particle

    NASA Astrophysics Data System (ADS)

    Ren, Jun; Zhang, Weixuan; Yang, Bing; Zhang, Xiangdong

    2016-11-01

    A graphene wrapped dielectric particle has been proposed theoretically to realize tunable multi-qubit quantum phase gates (QPGs) with ultrahigh fidelity. By using a first-principles Green's function technique, the interactions between quantum emitters mediated by graphene plasmons have been investigated. We find that the spontaneous decay rates of these emitters can be strongly enhanced and controlled by means of the efficient excitations of eigenmodes in graphene. The collective subradiance and superradiance resulting from the graphene-mediated interactions have been predicted. Based on these phenomena, we propose the tunable multi-qubit QPGs. These phase gates have the advantage of sensitive adjustability by changing the Fermi level or the electrostatic gating in graphene, at the same time they possess very high fidelities due to the small dissipation in the graphene monolayer.

  16. Designing High-Fidelity Single-Shot Three-Qubit Gates: A Machine-Learning Approach

    NASA Astrophysics Data System (ADS)

    Zahedinejad, Ehsan; Ghosh, Joydip; Sanders, Barry C.

    2016-11-01

    Three-qubit quantum gates are key ingredients for quantum error correction and quantum-information processing. We generate quantum-control procedures to design three types of three-qubit gates, namely Toffoli, controlled-not-not, and Fredkin gates. The design procedures are applicable to a system comprising three nearest-neighbor-coupled superconducting artificial atoms. For each three-qubit gate, the numerical simulation of the proposed scheme achieves 99.9% fidelity, which is an accepted threshold fidelity for fault-tolerant quantum computing. We test our procedure in the presence of decoherence-induced noise and show its robustness against random external noise generated by the control electronics. The three-qubit gates are designed via the machine-learning algorithm called subspace-selective self-adaptive differential evolution.

  17. Finite grid instability and spectral fidelity of the electrostatic Particle-In-Cell algorithm

    SciTech Connect

    Huang, C. -K.; Zeng, Y.; Wang, Y.; Meyers, M. D.; Yi, S.; Albright, B. J.

    2016-10-01

    The origin of the Finite Grid Instability (FGI) is studied by resolving the dynamics in the 1D electrostatic Particle-In-Cell (PIC) model in the spectral domain at the single particle level and at the collective motion level. The spectral fidelity of the PIC model is contrasted with the underlying physical system or the gridless model. The systematic spectral phase and amplitude errors from the charge deposition and field interpolation are quantified for common particle shapes used in the PIC models. Lastly, it is shown through such analysis and in simulations that the lack of spectral fidelity relative to the physical system due to the existence of aliased spatial modes is the major cause of the FGI in the PIC model.

  18. Band-selective shaped pulse for high fidelity quantum control in diamond

    SciTech Connect

    Chang, Yan-Chun; Xing, Jian; Liu, Gang-Qin; Jiang, Qian-Qing; Li, Wu-Xia; Zhang, Fei-Hao; Gu, Chang-Zhi; Pan, Xin-Yu; Long, Gui-Lu

    2014-06-30

    High fidelity quantum control of qubits is crucially important for realistic quantum computing, and it becomes more challenging when there are inevitable interactions between qubits. We introduce a band-selective shaped pulse, refocusing BURP (REBURP) pulse, to cope with the problems. The electron spin of nitrogen-vacancy centers in diamond is flipped with high fidelity by the REBURP pulse. In contrast with traditional rectangular pulses, the shaped pulse has almost equal excitation effect in a sharply edged region (in frequency domain). So the three sublevels of host {sup 14}N nuclear spin can be flipped accurately simultaneously, while unwanted excitations of other sublevels (e.g., of a nearby {sup 13}C nuclear spin) is well suppressed. Our scheme can be used for various applications such as quantum metrology, quantum sensing, and quantum information process.

  19. Difference mapping method using least square support vector regression for variable-fidelity metamodelling

    NASA Astrophysics Data System (ADS)

    Zheng, Jun; Shao, Xinyu; Gao, Liang; Jiang, Ping; Qiu, Haobo

    2015-06-01

    Engineering design, especially for complex engineering systems, is usually a time-consuming process involving computation-intensive computer-based simulation and analysis methods. A difference mapping method using least square support vector regression is developed in this work, as a special metamodelling methodology that includes variable-fidelity data, to replace the computationally expensive computer codes. A general difference mapping framework is proposed where a surrogate base is first created, then the approximation is gained by a mapping the difference between the base and the real high-fidelity response surface. The least square support vector regression is adopted to accomplish the mapping. Two different sampling strategies, nested and non-nested design of experiments, are conducted to explore their respective effects on modelling accuracy. Different sample sizes and three approximation performance measures of accuracy are considered.

  20. The quantum fidelity for the time-periodic singular harmonic oscillator

    NASA Astrophysics Data System (ADS)

    Combescure, Monique

    2006-03-01

    In this paper we perform an exact study of "quantum fidelity" (also called Loschmidt echo) for the time-periodic quantum harmonic oscillator of the following Hamiltonian: Ĥg(t)≔(P2/2)+f(t)(Q2/2)+(g2/Q2), when compared with the quantum evolution induced by Ĥ0(t) (g=0), in the case where f is a T-periodic function and g a real constant. The reference (initial) state is taken to be an arbitrary "generalized coherent state" in the sense of Perelomov. We show that, starting with a quadratic decrease in time in the neighborhood of t =0, this quantum fidelity may recur to its initial value 1 at an infinite sequence of times tk. We discuss the result when the classical motion induced by Hamiltonian Ĥ0(t) is assumed to be stable versus unstable.

  1. Replication fidelity assessment of large area sub-μm structured polymer surfaces using scatterometry

    NASA Astrophysics Data System (ADS)

    Calaon, M.; Madsen, M. H.; Weirich, J.; Hansen, H. N.; Tosello, G.; Hansen, P. E.; Garnaes, J.; Tang, P. T.

    2015-12-01

    The present study addresses one of the key challenges in the product quality control of transparent structured polymer substrates, the replication fidelity of sub-μm structures over a large area. Additionally the work contributes to the development of new techniques focused on in-line characterization of large nanostructured surfaces using scatterometry. In particular an approach to quantify the replication fidelity of high volume manufacturing processes such as polymer injection moulding is presented. Both periodic channels and semi-spherical structures were fabricated on nickel shims used for later injection moulding of Cyclic-olefin-copolymer (COC) substrate were the sub-μm features where ultimately transferred. The scatterometry system was validated using calibrated atomic force microscopy measurements and a model based on scalar diffraction theory employed to calculate the expected angular distribution of the reflected and the transmitted intensity for the nickel surfaces and structured COC and, respectively.

  2. Problems affecting the fidelity of pressure measuring instruments for planetary probes

    NASA Technical Reports Server (NTRS)

    Hudson, J. B.

    1972-01-01

    Determination is made of the nature and magnitude of surface-related effects that cause errors in pressure measuring instruments, with special reference being made to instruments intended for use in planetary probes. The interaction of gases with clean surfaces of metals likely to be used as gage construction materials was studied. Special emphasis was placed on the adsorption, chemical reaction, and electron-induced desorption processes. The results indicated that all metals tested were subject to surface processes which would degrade gage fidelity. It was also found, however, that the formation of inert adsorbed layers on these metal surfaces, such as carbon on platinum, greatly reduced or eliminated these effects. This process, combined with a system design which avoids contact between reactive gases and hot filaments, appears to offer the most promising solution to the gage fidelity problem.

  3. High-fidelity continuous-variable quantum teleportation toward multistep quantum operations

    SciTech Connect

    Yukawa, Mitsuyoshi; Furusawa, Akira; Benichi, Hugo

    2008-02-15

    The progress in quantum operations of continuous-variable (CV) schemes can be reduced to that in CV quantum teleportation. The fidelity of quantum teleportation of an optical setup is limited by the finite degree of quantum correlation that can be prepared with a pair of finitely squeezed states. Reports of improvement of squeezing level have appeared recently, and we adopted the improved methods in our experimental system of quantum teleportation. As a result, we teleported a coherent state with a fidelity F=0.83{+-}0.01, which is better than any other figures reported to date, to our knowledge. In this paper, we introduce a measure n{sub s}, the number of teleportations expected to be carried out sequentially. Our result corresponds to n{sub s}=5.0{+-}0.4. It suggests that our improvement would enable us to proceed toward more advanced quantum operations involving multiple steps.

  4. Teleportation fidelity as a probe of sub-Planck phase-space structure

    SciTech Connect

    Scott, A.J. Caves, Carlton M.

    2008-11-15

    We investigate the connection between sub-Planck structure in the Wigner function and the output fidelity of continuous-variable teleportation protocols. When the teleporting parties share a two-mode squeezed state as an entangled resource, high fidelity in the output state requires a squeezing large enough that the smallest sub-Planck structures in an input pure state are teleported faithfully. We formulate this relationship, which leads to an explicit relation between the fine-scale structure in the Wigner function and large-scale extent of the Wigner function, and we treat specific examples, including coherent, number, and random states and states produced by chaotic dynamics. We generalize the pure-state results to teleportation of mixed states.

  5. Retrieval of high-fidelity memory arises from distributed cortical networks.

    PubMed

    Wais, Peter E; Jahanikia, Sahar; Steiner, Daniel; Stark, Craig E L; Gazzaley, Adam

    2017-04-01

    Medial temporal lobe (MTL) function is well established as necessary for memory of facts and events. It is likely that lateral cortical regions critically guide cognitive control processes to tune in high-fidelity details that are most relevant for memory retrieval. Here, convergent results from functional and structural MRI show that retrieval of detailed episodic memory arises from lateral cortical-MTL networks, including regions of inferior frontal and angular gyrii. Results also suggest that recognition of items based on low-fidelity, generalized information, rather than memory arising from retrieval of relevant episodic details, is not associated with functional connectivity between MTL and lateral cortical regions. Additionally, individual differences in microstructural properties in white matter pathways, associated with distributed MTL-cortical networks, are positively correlated with better performance on a mnemonic discrimination task.

  6. Creation of a High-fidelity, Low-cost Pediatric Skull Fracture Ultrasound Phantom.

    PubMed

    Soucy, Zachary P; Mills, Lisa; Rose, John S; Kelley, Kenneth; Ramirez, Francisco; Kuppermann, Nathan

    2015-08-01

    Over the past decade, point-of-care ultrasound has become a common tool used for both procedures and diagnosis. Developing high-fidelity phantoms is critical for training in new and novel point-of-care ultrasound applications. Detecting skull fractures on ultrasound imaging in the younger-than-2-year-old patient is an emerging area of point-of-care ultrasound research. Identifying a skull fracture on ultrasound imaging in this age group requires knowledge of the appearance and location of sutures to distinguish them from fractures. There are currently no commercially available pediatric skull fracture models. We outline a novel approach to building a cost-effective, simple, high-fidelity pediatric skull fracture phantom to meet a unique training requirement.

  7. High-fidelity single-shot three-qubit gates via machine learning

    NASA Astrophysics Data System (ADS)

    Zahedinejad, Ehsan; Ghosh, Joydip; Sanders, Barry C.

    Three-qubit quantum gates play a crucial role in quantum error correction and quantum information processing. Here I discuss how to generate policies for quantum control to design three-qubit gates namely, Toffoli, Controlled-Not-Not and Fredkin gates for an architecture of nearest-neighbor-coupled superconducting artificial atoms. The resulted fidelity for each gate is above the 99.9% which is the threshold fidelity for fault-tolerant quantum computing. We test our policy in the presence of decoherence-induced noise as well as show its robustness under random external noise. The three-qubit gates are designed via our machine learning algorithm called Subspace-Selective Self-Adaptive Differential Evolution (SuSSADE). NSERC, AITF and University of Calgarys Eyes High Fellowship Program.

  8. High Fidelity Singlet-Triplet S-T_ Qubits in Inhomogeneous Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Wong, Clement; Eriksson, Mark; Coppersmith, Sue; Friesen, Mark

    2015-03-01

    We propose an optimal set of quantum gates for a singlet-triplet qubit in a double quantum dot with two electrons utilizing the S-T- subspace. Qubit rotations are driven by the applied magnetic field and an orthogonal field gradient provided by a micromagnet. We optimize the fidelity of this qubit as a function of magnetic fields, taking advantage of ``sweet spots'' where the rotation frequencies are independent of the energy level detuning, providing protection against charge noise. We simulate gate operations and qubit rotations in the presence of quasistatic noise from charge and nuclear spins as well as leakage to nonqubit states, and predict that in silicon quantum dots gate fidelities greater than 99 % can be achieved for two nearly-orthogonal rotation axes. This work was supported in part by NSF, ARO, UW-Madison Bridge Funding, and the Intelligence Community Postdoctoral Research Fellowship Program.

  9. Improving quantum gate fidelities by using a qubit to measure microwave pulse distortions.

    PubMed

    Gustavsson, Simon; Zwier, Olger; Bylander, Jonas; Yan, Fei; Yoshihara, Fumiki; Nakamura, Yasunobu; Orlando, Terry P; Oliver, William D

    2013-01-25

    We present a new method for determining pulse imperfections and improving the single-gate fidelity in a superconducting qubit. By applying consecutive positive and negative π pulses, we amplify the qubit evolution due to microwave pulse distortions, which causes the qubit state to rotate around an axis perpendicular to the intended rotation axis. Measuring these rotations as a function of pulse period allows us to reconstruct the shape of the microwave pulse arriving at the sample. Using the extracted response to predistort the input signal, we are able to reduce the average error per gate by 37%, which enables us to reach an average single-qubit gate fidelity higher than 0.998.

  10. High-speed and high-fidelity system and method for collecting network traffic

    DOEpatents

    Weigle, Eric H.

    2010-08-24

    A system is provided for the high-speed and high-fidelity collection of network traffic. The system can collect traffic at gigabit-per-second (Gbps) speeds, scale to terabit-per-second (Tbps) speeds, and support additional functions such as real-time network intrusion detection. The present system uses a dedicated operating system for traffic collection to maximize efficiency, scalability, and performance. A scalable infrastructure and apparatus for the present system is provided by splitting the work performed on one host onto multiple hosts. The present system simultaneously addresses the issues of scalability, performance, cost, and adaptability with respect to network monitoring, collection, and other network tasks. In addition to high-speed and high-fidelity network collection, the present system provides a flexible infrastructure to perform virtually any function at high speeds such as real-time network intrusion detection and wide-area network emulation for research purposes.

  11. High-Fidelity Qubit Measurement using a Superconducting Low-Inductance Undulatory Galvanometer Microwave Amplifier

    NASA Astrophysics Data System (ADS)

    Thorbeck, Ted; Hover, David; Zhu, Shaojiang; Ribeill, Guilhem; Sank, Daniel; Barends, Rami; Martinis, John; McDermott, Robert

    2014-03-01

    We describe a high-fidelity dispersive measurement of a superconducting Xmon qubit using a microwave amplifier based on the Superconducting Low-inductance Undulatory Galvanometer (SLUG). We will show a qubit measurement fidelity of 99% in 700 ns with the SLUG, compared to 60% without the SLUG. The SLUG amplifier has a gain of 19 dB at 6.6 GHZ. It also improves the signal-to-noise ratio by 9 dB, compared the same circuit without the SLUG. Also, the SLUG amplifier has a large dynamic range, with an input saturation power corresponding to around 600 photons in the readout cavity. All of these properties make the SLUG a promising microwave amplifier for more complex quantum circuits.

  12. Analysis procedures and subjective flight results of a simulator validation and cue fidelity experiment

    NASA Technical Reports Server (NTRS)

    Carr, Peter C.; Mckissick, Burnell T.

    1988-01-01

    A joint experiment to investigate simulator validation and cue fidelity was conducted by the Dryden Flight Research Facility of NASA Ames Research Center (Ames-Dryden) and NASA Langley Research Center. The primary objective was to validate the use of a closed-loop pilot-vehicle mathematical model as an analytical tool for optimizing the tradeoff between simulator fidelity requirements and simulator cost. The validation process includes comparing model predictions with simulation and flight test results to evaluate various hypotheses for differences in motion and visual cues and information transfer. A group of five pilots flew air-to-air tracking maneuvers in the Langley differential maneuvering simulator and visual motion simulator and in an F-14 aircraft at Ames-Dryden. The simulators used motion and visual cueing devices including a g-seat, a helmet loader, wide field-of-view horizon, and a motion base platform.

  13. Fidelity in the Field: Developing Infrastructure and Fine-tuning Measurement

    PubMed Central

    Herschell, Amy D.

    2010-01-01

    Mazzucchelli and Sanders (2010) provide a thoughtful, detailed, and complex description of how to encourage flexible fidelity to one well-established, evidence-based treatment, the Triple P- Positive Parenting Program. As the authors highlight, many of the “lessons learned” from this wealth of treatment, research, and implementation experience were developed over decades and can be applied to other evidence based treatments. Underlying many of the recommendations provided by Mazzucchelli and Sanders (2010) is a well-refined infrastructure to support implementation and the need to refine the measurement of fidelity in the field. This commentary will discuss each of those topics. It seems that we have many lessons to learn and hurdles to clear in this emerging area of science, which will be hastened by pioneers like Mazzucchelli and Sanders. PMID:21116442

  14. Experimental generation of a high-fidelity four-photon linear cluster state

    NASA Astrophysics Data System (ADS)

    Zhang, Chao; Huang, Yun-Feng; Liu, Bi-Heng; Li, Chuan-Feng; Guo, Guang-Can

    2016-06-01

    Cluster state plays a crucial role in one-way quantum computation. Here, we propose and experimentally demonstrate a scheme to prepare an ultrahigh-fidelity four-photon linear cluster state via a spontaneous parametric down-conversion process. The state fidelity is measured to be 0.9517 ±0.0027 . Our scheme can be directly extended to more photons to generate an N -qubit linear cluster state. Furthermore, our scheme is optimal for generating photonic linear cluster states in the sense of achieving the maximal success probability and having the simplest strategy. The key idea is that the photon pairs are prepared in some special nonmaximally entangled states instead of the normal Bell states. To generate a 2 N -qubit linear cluster state from N pairs of entangled photons, only (N -1 ) Hong-Ou-Mandel interferences are needed and a success probability of (1/4) N -1 is achieved.

  15. High-Fidelity Single-Shot Toffoli Gate via Quantum Control.

    PubMed

    Zahedinejad, Ehsan; Ghosh, Joydip; Sanders, Barry C

    2015-05-22

    A single-shot Toffoli, or controlled-controlled-not, gate is desirable for classical and quantum information processing. The Toffoli gate alone is universal for reversible computing and, accompanied by the Hadamard gate, forms a universal gate set for quantum computing. The Toffoli gate is also a key ingredient for (nontopological) quantum error correction. Currently Toffoli gates are achieved by decomposing into sequentially implemented single- and two-qubit gates, which require much longer times and yields lower overall fidelities compared to a single-shot implementation. We develop a quantum-control procedure to construct a single-shot Toffoli gate for three nearest-neighbor-coupled superconducting transmon systems such that the fidelity is 99.9% and is as fast as an entangling two-qubit gate under the same realistic conditions. The gate is achieved by a nongreedy quantum control procedure using our enhanced version of the differential evolution algorithm.

  16. Finite grid instability and spectral fidelity of the electrostatic Particle-In-Cell algorithm

    NASA Astrophysics Data System (ADS)

    Huang, C.-K.; Zeng, Y.; Wang, Y.; Meyers, M. D.; Yi, S.; Albright, B. J.

    2016-10-01

    The origin of the Finite Grid Instability (FGI) is studied by resolving the dynamics in the 1D electrostatic Particle-In-Cell (PIC) model in the spectral domain at the single particle level and at the collective motion level. The spectral fidelity of the PIC model is contrasted with the underlying physical system or the gridless model. The systematic spectral phase and amplitude errors from the charge deposition and field interpolation are quantified for common particle shapes used in the PIC models. It is shown through such analysis and in simulations that the lack of spectral fidelity relative to the physical system due to the existence of aliased spatial modes is the major cause of the FGI in the PIC model.

  17. Rotorcraft brownout mitigation through flight path optimization using a high fidelity rotorcraft simulation model

    NASA Astrophysics Data System (ADS)

    Alfred, Jillian Samantha

    Brownout conditions often occur during approach, landing, and take off in a desert environment and involve the entrainment and mobilization of loose sediment and dust into the rotor flow field. For this research, a high fidelity flight dynamics model is used to perform a study on brownout mitigation through operational means of flight path. In order for the high fidelity simulation to model an approach profile, a method for following specific profiles was developed. An optimization study was then performed using this flight dynamics model in a comprehensive brownout simulation. The optimization found a local shallow optimum approach and a global steep optimum approach minimized the intensity of the resulting brownout clouds. These results were consistent previous mitigation studies and operational methods. The results also demonstrated that the addition of a full rotorcraft model into the brownout simulation changed the characteristics of the velocity flow field, and hence changing the character of the brownout cloud that was produced.

  18. Finite grid instability and spectral fidelity of the electrostatic Particle-In-Cell algorithm

    DOE PAGES

    Huang, C. -K.; Zeng, Y.; Wang, Y.; ...

    2016-10-01

    The origin of the Finite Grid Instability (FGI) is studied by resolving the dynamics in the 1D electrostatic Particle-In-Cell (PIC) model in the spectral domain at the single particle level and at the collective motion level. The spectral fidelity of the PIC model is contrasted with the underlying physical system or the gridless model. The systematic spectral phase and amplitude errors from the charge deposition and field interpolation are quantified for common particle shapes used in the PIC models. Lastly, it is shown through such analysis and in simulations that the lack of spectral fidelity relative to the physical systemmore » due to the existence of aliased spatial modes is the major cause of the FGI in the PIC model.« less

  19. Islands in the sea: extreme female natal site fidelity in the Australian sea lion, Neophoca cinerea.

    PubMed

    Campbell, R A; Gales, N J; Lento, G M; Baker, C S

    2008-02-23

    Pinnipeds (seals, fur seals, sea lions and walrus) form large breeding aggregations with females often remaining faithful to a natal site or area. In these cases, females are philopatric to regional areas on broad geographical scales of hundreds to thousands of kilometers. An investigation of variation in a control region sequence of mtDNA in the Australian sea lion (Neophoca cinerea) has shown a case of extreme female natal site fidelity that has resulted in almost fixed population differentiation across its range (PhiST=0.93). This high level of population subdivision over short geographical distances (approx. 60 km) is unparalleled in any social marine mammal and reflects the unique life-history traits of this rare species. The high level of population subdivision and exclusive female natal site fidelity has important ramifications for conservation management, and poses many interesting questions of both academic and applied interest.

  20. The validity and incremental validity of knowledge tests, low-fidelity simulations, and high-fidelity simulations for predicting job performance in advanced-level high-stakes selection.

    PubMed

    Lievens, Filip; Patterson, Fiona

    2011-09-01

    In high-stakes selection among candidates with considerable domain-specific knowledge and experience, investigations of whether high-fidelity simulations (assessment centers; ACs) have incremental validity over low-fidelity simulations (situational judgment tests; SJTs) are lacking. Therefore, this article integrates research on the validity of knowledge tests, low-fidelity simulations, and high-fidelity simulations in advanced-level high-stakes settings. A model and hypotheses of how these 3 predictors work in combination to predict job performance were developed. In a sample of 196 applicants, all 3 predictors were significantly related to job performance. Both the SJT and the AC had incremental validity over the knowledge test. Moreover, the AC had incremental validity over the SJT. Model tests showed that the SJT fully mediated the effects of declarative knowledge on job performance, whereas the AC partially mediated the effects of the SJT.

  1. Progress report on development of intermediate fidelity full assembly analysis methods.

    SciTech Connect

    Hu, R.; Fanning, T. H.

    2011-09-30

    While high fidelity modeling capabilities for various physics phenomena are being pursued under advanced modeling and simulation initiatives under the DOE Office of Nuclear Energy, they generally rely on high-performance computation facilities and are too expensive to be used for parameter-space exploration or design analysis. One-dimensional system codes have been used for a long time and have reached a degree of maturity, but limit their validity to specific applications. Thus, an intermediate fidelity (IF) modeling method is being pursued in this work for a fast-running, modest-fidelity, whole-core transient analyses capability. The new approach is essential for design scoping and engineering analyses and could lead to improvements in the design of the new generations of reactors and to the reduction of uncertainties in safety analysis. This report summarizes the initial effort on the development of the intermediate-fidelity full assembly modeling method. The requirements and the desired merits of the IF approach have been defined. A three-dimensional momentum source model has been developed to model the anisotropic flow in the wire-wrapped rod bundle without the need to resolve the geometric details. It has been confirmed that the momentum source model works well if its affecting region is accurately imposed. The validity of the model is further verified by mesh and parameter sensitivity studies. The developed momentum source model, in principle, can be applied to any wire-wrapped bundle geometries and any flow regimes; while the modeling strategy can be applied to other conditions with complex or distorted geometry, such as flow in blocked channels.

  2. Enhanced Fidelity to a Psychosocial Treatment for Bipolar Disorder: Results from a Randomized Controlled Implementation Trial

    PubMed Central

    Waxmonsky, Jeanette; Kilbourne, Amy M.; Goodrich, David E.; Nord, Kristina M.; Laird, Christina; Lai, Zongshan; Clogston, Julia; Kim, Hyungjin Myra; Miller, Christopher J.; Bauer, Mark S.

    2014-01-01

    Background We determined whether application of a novel implementation intervention (Enhanced Replicating Effective Programs-REP) versus its standard, dissemination-focused version (REP) improved fidelity to bipolar disorder treatment (Life Goals Collaborative Care- LGCC). Methods Five community practices from Michigan and Colorado were randomized to receive LGCC using Enhanced or standard REP. One provider at each practice implemented LGCC which included patient self-management support (4 group sessions focused on symptoms and behavior goals), guideline dissemination to providers, and ongoing phone care management focused on maintaining behavior goals and provider engagement. Standard REP included intervention packaging (i.e., translation of LGCC core components into user-friendly language), training, and as-needed technical assistance. Enhanced REP added customization of LGCC and ongoing, proactive technical assistance through an internal and external facilitator that focused on enhancing provider buy-in and uptake. Multiple and logistic regression analyses determined the impact on patient-level LGCC fidelity between Enhanced versus standard REP. Results Participants (N=384; mean age = 42 years, 67% women, 29% nonwhite) averaged 3.0 out of 4 LGCC group sessions and had 4.0 care management contacts. Enhanced REP implementation was associated with 2.6 (p<.001) greater total number of sessions/contacts than standard REP, which was driven by 2.5 (p<.01) more care management contacts, after adjusting for patient factors. Women and those with a history of homelessness received fewer sessions. Conclusions Enhanced REP implementation was associated with improved LGCC fidelity, primarily for care management contacts. Additional customization of interventions such as LGCC may be needed to ensure adequate treatment fidelity for key vulnerable populations. PMID:24129806

  3. SOWFA Super-Controller: A High-Fidelity Tool for Evaluating Wind Plant Control Approaches

    SciTech Connect

    Fleming, P.; Gebraad, P.; van Wingerden, J. W.; Lee, S.; Churchfield, M.; Scholbrock, A.; Michalakes, J.; Johnson, K.; Moriarty, P.

    2013-01-01

    This paper presents a new tool for testing wind plant controllers in the Simulator for Offshore Wind Farm Applications (SOWFA). SOWFA is a high-fidelity simulator for the interaction between wind turbine dynamics and the fluid flow in a wind plant. The new super-controller testing environment in SOWFA allows for the implementation of the majority of the wind plant control strategies proposed in the literature.

  4. High-fidelity patient simulation in nursing education: an integrative review.

    PubMed

    Weaver, Amy

    2011-01-01

    An integrative review was undertaken to analyze studies published since 1998 on the use of high-fidelity patient simulation (HFPS) in undergraduate nursing education. This review found that HFPS benefits nursing students in terms of knowledge, value, realism, and learner satisfaction;findings were mixed in the areas of student confidence, knowledge transfer, and stress. Further research in these and other areas will determine whether its increased use is warranted.

  5. A Review of the Literature on Training Simulators: Translators: Transfer of Training and Simulator Fidelity.

    DTIC Science & Technology

    1984-04-01

    7 -. ~~State-of-the-art . . . . . ................................... 9 C . EVALUATION OF TRAINING EFFECTIVENESS...........14...Section B. A distinction between two types of training is made in Section C . The state-of-the-art on simulator training is also described. Then "training...provided in Section C . -v Section D describes the issue of simulator fidelity, including its definition, relationships with training, measurement and

  6. Scaling up the evaluation of psychotherapy: evaluating motivational interviewing fidelity via statistical text classification

    PubMed Central

    2014-01-01

    Background Behavioral interventions such as psychotherapy are leading, evidence-based practices for a variety of problems (e.g., substance abuse), but the evaluation of provider fidelity to behavioral interventions is limited by the need for human judgment. The current study evaluated the accuracy of statistical text classification in replicating human-based judgments of provider fidelity in one specific psychotherapy—motivational interviewing (MI). Method Participants (n = 148) came from five previously conducted randomized trials and were either primary care patients at a safety-net hospital or university students. To be eligible for the original studies, participants met criteria for either problematic drug or alcohol use. All participants received a type of brief motivational interview, an evidence-based intervention for alcohol and substance use disorders. The Motivational Interviewing Skills Code is a standard measure of MI provider fidelity based on human ratings that was used to evaluate all therapy sessions. A text classification approach called a labeled topic model was used to learn associations between human-based fidelity ratings and MI session transcripts. It was then used to generate codes for new sessions. The primary comparison was the accuracy of model-based codes with human-based codes. Results Receiver operating characteristic (ROC) analyses of model-based codes showed reasonably strong sensitivity and specificity with those from human raters (range of area under ROC curve (AUC) scores: 0.62 – 0.81; average AUC: 0.72). Agreement with human raters was evaluated based on talk turns as well as code tallies for an entire session. Generated codes had higher reliability with human codes for session tallies and also varied strongly by individual code. Conclusion To scale up the evaluation of behavioral interventions, technological solutions will be required. The current study demonstrated preliminary, encouraging findings regarding the utility

  7. No More Zombies! High-Fidelity Character Autonomy for Virtual Small-Unit Training

    DTIC Science & Technology

    2012-01-01

    Interservice/Industry Training, Simulation, and Education Conference (I/ITSEC) 2012 2012 Paper No. 12045 Page 1 of 11 No More Zombies ! High...valid OMB control number. 1. REPORT DATE 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE No More Zombies ...More Zombies ! High-Fidelity Character Autonomy for Virtual Small-Unit Training Brian S. Stensrud, Ph.D., Angela Woods, Samuel Wintermute

  8. Implementing high-fidelity simulations with large groups of nursing students.

    PubMed

    Hooper, Barbara; Shaw, Luanne; Zamzam, Rebekah

    2015-01-01

    Nurse educators are increasing the use of simulation as a teaching strategy. Simulations are conducted typically with a small group of students. This article describes the process for implementing 6 high-fidelity simulations with a large group of undergraduate nursing students. The goal was to evaluate if student knowledge increased on postsimulation quiz scores when only a few individuals actively participated in the simulation while the other students observed.

  9. High-Fidelity, Computational Modeling of Non-Equilibrium Discharges for Combustion Applications

    DTIC Science & Technology

    2013-10-01

    pulsed ignition of supersonic combustion Plasma OFF Plasma ON OH PLIF 14 Approach 15  High fidelity multi- dimensional computational simulations...pulse freq. Ref: H. Do, M. G. Mungal and M. A. Cappelli., “ Jet Flame Ignition in a Supersonic Crossflow using a Pulsed Nonequilibrium Plasma...TACC) • Problems with large two - dimensional meshes and large chemistries scales well to a few 100 processors, cutting simulation times from

  10. Free Energy Gap and Statistical Thermodynamic Fidelity of DNA Codes (Postprint)

    DTIC Science & Technology

    2007-01-01

    reverse-complement unless otherwise stated. For strand x, let Nx denote its complement. A (perfect) Watson - Crick duplex is the joining of complement...is possible for complementary sequences to form a non-perfectly aligned duplex, we will call any x W Nx duplex a Watson - Crick (WC) duplex. Two...DATES COVERED (From - To) 4. TITLE AND SUBTITLE FREE ENERGY GAP AND STATISTICAL THERMODYNAMIC FIDELITY OF DNA CODES 5a. CONTRACT NUMBER FA8750-07

  11. Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA polymerase.

    PubMed

    Ulrich, Sébastien; Kool, Eric T

    2011-11-29

    DNA-dependent RNA polymerases such as T7 RNA polymerase (T7 RNAP) perform the transcription of DNA into mRNA with high efficiency and high fidelity. Although structural studies have provided a detailed account of the molecular basis of transcription, the relative importance of factors like hydrogen bonds and steric effects remains poorly understood. We report herein the first study aimed at systematically probing the importance of steric and electrostatic effects on the efficiency and fidelity of DNA transcription by T7 RNAP. We used synthetic nonpolar analogues of thymine with sizes varying in subangstrom increments to probe the steric requirements of T7 RNAP during the elongation mode of transcription. Enzymatic assays with internal radiolabeling were performed to compare the efficiency of transcription of modified DNA templates with a natural template containing thymine as a reference. Furthermore, we analyzed effects on the fidelity by measuring the composition of RNA transcripts by enzymatic digestion followed by two-dimensional thin layer chromatography separation. Our results demonstrate that hydrogen bonds play an important role in the efficiency of transcription but, interestingly, do not appear to be required for faithful transcription. Steric effects (size and shape variations) are found to be significant both in insertion of a new RNA base and in extension beyond it.

  12. Improving model fidelity and sensitivity for complex systems through empirical information theory

    PubMed Central

    Majda, Andrew J.; Gershgorin, Boris

    2011-01-01

    In many situations in contemporary science and engineering, the analysis and prediction of crucial phenomena occur often through complex dynamical equations that have significant model errors compared with the true signal in nature. Here, a systematic information theoretic framework is developed to improve model fidelity and sensitivity for complex systems including perturbation formulas and multimodel ensembles that can be utilized to improve both aspects of model error simultaneously. A suite of unambiguous test models is utilized to demonstrate facets of the proposed framework. These results include simple examples of imperfect models with perfect equilibrium statistical fidelity where there are intrinsic natural barriers to improving imperfect model sensitivity. Linear stochastic models with multiple spatiotemporal scales are utilized to demonstrate this information theoretic approach to equilibrium sensitivity, the role of increasing spatial resolution in the information metric for model error, and the ability of imperfect models to capture the true sensitivity. Finally, an instructive statistically nonlinear model with many degrees of freedom, mimicking the observed non-Gaussian statistical behavior of tracers in the atmosphere, with corresponding imperfect eddy-diffusivity parameterization models are utilized here. They demonstrate the important role of additional stochastic forcing of imperfect models in order to systematically improve the information theoretic measures of fidelity and sensitivity developed here. PMID:21646534

  13. Link between statistical equilibrium fidelity and forecasting skill for complex systems with model error.

    PubMed

    Majda, Andrew J; Gershgorin, Boris

    2011-08-02

    Understanding and improving the predictive skill of imperfect models for complex systems in their response to external forcing is a crucial issue in diverse applications such as for example climate change science. Equilibrium statistical fidelity of the imperfect model on suitable coarse-grained variables is a necessary but not sufficient condition for this predictive skill, and elementary examples are given here demonstrating this. Here, with equilibrium statistical fidelity of the imperfect model, a direct link is developed between the predictive fidelity of specific test problems in the training phase where the perfect natural system is observed and the predictive skill for the forced response of the imperfect model by combining appropriate concepts from information theory with other concepts based on the fluctuation dissipation theorem. Here a suite of mathematically tractable models with nontrivial eddy diffusivity, variance, and intermittent non-Gaussian statistics mimicking crucial features of atmospheric tracers together with stochastically forced standard eddy diffusivity approximation with model error are utilized to illustrate this link.

  14. Behavioral evidence for host fidelity among populations of the parasitic wasp, Diachasma alloeum (Muesebeck)

    NASA Astrophysics Data System (ADS)

    Stelinski, L. L.; Liburd, O. E.

    2005-02-01

    The concept of “host fidelity,” where host-specific mating occurs in close proximity to the oviposition site and location of larval development, is thought to impart a pre-mating isolation mechanism for sympatric speciation (sensu members of the genus Rhagoletis). The apple maggot fly, Rhagoletis pomonella, and the blueberry maggot fly, R. mendax, are morphologically similar sibling species thought to have speciated in sympatry by divergence of host plant association. Both of these fly species are attacked by the specialist braconid parasitoid, Diachasma alloeum. The current study demonstrates that both male and female D. alloeum exhibit a behavioral preference for the odor of the fruit of their larval Rhagoletis host species. Specifically, those D. alloeum emerging from puparia of R. pomonella are preferentially attracted to hawthorn fruit and those emerging from puparia of R. mendax are preferentially attracted to blueberry fruit. However, male D. alloeum reared from either R. pomonella or R. mendax were equally attracted to females originating from both Rhagoletis species. We suggest that the data herein present evidence for “host fidelity,” where populations of D. alloeum exhibit a greater tendency to mate and reproduce among the host plants of their preferred Rhagoletis hosts. Furthermore, host fidelity may have resulted in the evolution of distinct host races of D. alloeum tracking the speciation of their larval Rhagoletis prey.

  15. A Methodology for Evaluating the Fidelity of Ground-Based Flight Simulators

    NASA Technical Reports Server (NTRS)

    Zeyada, Y.; Hess, R. A.

    1999-01-01

    An analytical and experimental investigation was undertaken to model the manner in which pilots perceive and utilize visual, proprioceptive, and vestibular cues in a ground-based flight simulator. The study was part of a larger research effort which has the creation of a methodology for determining flight simulator fidelity requirements as its ultimate goal. The study utilized a closed-loop feedback structure of the pilot/simulator system which included the pilot, the cockpit inceptor, the dynamics of the simulated vehicle and the motion system. With the exception of time delays which accrued in visual scene production in the simulator, visual scene effects were not included in this study. The NASA Ames Vertical Motion Simulator was used in a simple, single-degree of freedom rotorcraft bob-up/down maneuver. Pilot/vehicle analysis and fuzzy-inference identification were employed to study the changes in fidelity which occurred as the characteristics of the motion system were varied over five configurations. The data from three of the five pilots that participated in the experimental study were analyzed in the fuzzy-inference identification. Results indicate that both the analytical pilot/vehicle analysis and the fuzzy-inference identification can be used to reflect changes in simulator fidelity for the task examined.

  16. Chloroplast envelope protein targeting fidelity is independent of cytosolic components in dual organelle assays

    PubMed Central

    Kriechbaumer, Verena; Abell, Ben M.

    2012-01-01

    The general mechanisms of intracellular protein targeting are well established, and depend on a targeting sequence in the protein, which is recognized by a targeting factor. Once a membrane protein is delivered to the correct organelle its targeting sequence can be recognized by receptors and a translocase, leading to membrane insertion. However, the relative contribution of each step for generating fidelity and efficiency of the overall process has not been systematically addressed. Here, we use tail-anchored (TA) membrane proteins in cell-free competitive targeting assays to chloroplasts to show that targeting can occur efficiently and with high fidelity in the absence of all cytosolic components, suggesting that chloroplast envelope protein targeting is primarily dependent on events at the outer envelope. Efficiency of targeting was increased by the addition of complete cytosol, and by Hsp70 or Hsp90, depending on the protein, but none of these cytosolic components influenced the fidelity of targeting. Our results suggest that the main role of targeting factors in chloroplast localization is to increase targeting efficiency by maintaining recognition competency at the outer envelope. PMID:22783268

  17. A genetic assessment of polyandry and breeding-site fidelity in lemon sharks.

    PubMed

    DiBattista, Joseph D; Feldheim, Kevin A; Thibert-Plante, Xavier; Gruber, Samuel H; Hendry, Andrew P

    2008-07-01

    We here employ 11 microsatellite markers and recently developed litter reconstruction methods to infer mating system parameters (i.e. polyandry and breeding-site fidelity) at a lemon shark nursery site in Marquesas Key, Florida. Four hundred and eight juvenile or subadult sharks were genotyped over eight complete breeding seasons. Using this information, we were able to infer family structure, as well as fully or partially reconstruct genotypes of 46 mothers and 163 fathers. Multiple litter reconstruction methods were used, and novel simulations helped define apparent bias and precision of at least some mating system parameters. For Marquesas Key, we find that adult female lemon sharks display high levels of polyandry (81% of all litters sampled) and stronger fidelity to the nursery site than do males. Indeed, few male sharks sired offspring from more than one litter during the course of the study. These findings were quite similar to previous results from another lemon shark nursery site (Bimini, Bahamas), suggesting conserved mating system parameters despite significant variation in early life-history traits (i.e. body size and growth) among sites. The finding of at least some site fidelity in females also supports the need for careful conservation of each nursery.

  18. Large–Scale Movement and Reef Fidelity of Grey Reef Sharks

    PubMed Central

    Heupel, Michelle R.; Simpfendorfer, Colin A.; Fitzpatrick, Richard

    2010-01-01

    Despite an Indo-Pacific wide distribution, the movement patterns of grey reef sharks (Carcharhinus amblyrhynchos) and fidelity to individual reef platforms has gone largely unstudied. Their wide distribution implies that some individuals have dispersed throughout tropical waters of the Indo-Pacific, but data on large-scale movements do not exist. We present data from nine C. amblyrhynchos monitored within the Great Barrier Reef and Coral Sea off the coast of Australia. Shark presence and movements were monitored via an array of acoustic receivers for a period of six months in 2008. During the course of this monitoring few individuals showed fidelity to an individual reef suggesting that current protective areas have limited utility for this species. One individual undertook a large-scale movement (134 km) between the Coral Sea and Great Barrier Reef, providing the first evidence of direct linkage of C. amblyrhynchos populations between these two regions. Results indicate limited reef fidelity and evidence of large-scale movements within northern Australian waters. PMID:20224793

  19. Effects of VR system fidelity on analyzing isosurface visualization of volume datasets.

    PubMed

    Laha, Bireswar; Bowman, Doug A; Socha, John J

    2014-04-01

    Volume visualization is an important technique for analyzing datasets from a variety of different scientific domains. Volume data analysis is inherently difficult because volumes are three-dimensional, dense, and unfamiliar, requiring scientists to precisely control the viewpoint and to make precise spatial judgments. Researchers have proposed that more immersive (higher fidelity) VR systems might improve task performance with volume datasets, and significant results tied to different components of display fidelity have been reported. However, more information is needed to generalize these results to different task types, domains, and rendering styles. We visualized isosurfaces extracted from synchrotron microscopic computed tomography (SR-μCT) scans of beetles, in a CAVE-like display. We ran a controlled experiment evaluating the effects of three components of system fidelity (field of regard, stereoscopy, and head tracking) on a variety of abstract task categories that are applicable to various scientific domains, and also compared our results with those from our prior experiment using 3D texture-based rendering. We report many significant findings. For example, for search and spatial judgment tasks with isosurface visualization, a stereoscopic display provides better performance, but for tasks with 3D texture-based rendering, displays with higher field of regard were more effective, independent of the levels of the other display components. We also found that systems with high field of regard and head tracking improve performance in spatial judgment tasks. Our results extend existing knowledge and produce new guidelines for designing VR systems to improve the effectiveness of volume data analysis.

  20. Estimating the fidelity of T gates using standard interleaved randomized benchmarking

    NASA Astrophysics Data System (ADS)

    Harper, Robin; Flammia, Steven T.

    2017-03-01

    Randomized benchmarking is an important protocol for robustly characterizing the error rates of quantum gates. The technique is typically applied to the Clifford gates since they form a group that satisfies a convenient technical condition of forming a unitary 2-design, in addition to having a tight connection to fault-tolerant quantum computing and an efficient classical simulation. In order to achieve universal quantum computing one must add at least one additional gate such as the T gate (also known as the π/8 gate). Here we propose and analyze a simple variation of the standard interleaved RB protocol that can accurately estimate the average fidelity of the T gate while retaining the many advantages of a unitary 2-design and the fidelity guarantees that such a design delivers, as well as the efficient classical simulation property of the Clifford group. Our work complements prior methods that have succeeded in estimating T gate fidelities, but only by relaxing the 2-design constraint and using a more complicated data analysis.

  1. Modeling human pilot cue utilization with applications to simulator fidelity assessment.

    PubMed

    Zeyada, Y; Hess, R A

    2000-01-01

    An analytical investigation to model the manner in which pilots perceive and utilize visual, proprioceptive, and vestibular cues in a ground-based flight simulator was undertaken. Data from a NASA Ames Research Center vertical motion simulator study of a simple, single-degree-of-freedom rotorcraft bob-up/down maneuver were employed in the investigation. The study was part of a larger research effort that has the creation of a methodology for determining flight simulator fidelity requirements as its ultimate goal. The study utilized a closed-loop feedback structure of the pilot/simulator system that included the pilot, the cockpit inceptor, the dynamics of the simulated vehicle, and the motion system. With the exception of time delays that accrued in visual scene production in the simulator, visual scene effects were not included in this study. Pilot/vehicle analysis and fuzzy-inference identification were employed to study the changes in fidelity that occurred as the characteristics of the motion system were varied over five configurations. The data from three of the five pilots who participated in the experimental study were analyzed in the fuzzy-inference identification. Results indicate that both the analytical pilot/vehicle analysis and the fuzzy-inference identification can be used to identify changes in simulator fidelity for the task examined.

  2. GIS Data Based Automatic High-Fidelity 3D Road Network Modeling

    NASA Technical Reports Server (NTRS)

    Wang, Jie; Shen, Yuzhong

    2011-01-01

    3D road models are widely used in many computer applications such as racing games and driving simulations_ However, almost all high-fidelity 3D road models were generated manually by professional artists at the expense of intensive labor. There are very few existing methods for automatically generating 3D high-fidelity road networks, especially those existing in the real world. This paper presents a novel approach thai can automatically produce 3D high-fidelity road network models from real 2D road GIS data that mainly contain road. centerline in formation. The proposed method first builds parametric representations of the road centerlines through segmentation and fitting . A basic set of civil engineering rules (e.g., cross slope, superelevation, grade) for road design are then selected in order to generate realistic road surfaces in compliance with these rules. While the proposed method applies to any types of roads, this paper mainly addresses automatic generation of complex traffic interchanges and intersections which are the most sophisticated elements in the road networks

  3. A Structure Fidelity Approach for Big Data Collection in Wireless Sensor Networks

    PubMed Central

    Wu, Mou; Tan, Liansheng; Xiong, Naixue

    2015-01-01

    One of the most widespread and important applications in wireless sensor networks (WSNs) is the continuous data collection, such as monitoring the variety of ambient temperature and humidity. Due to the sensor nodes with a limited energy supply, the reduction of energy consumed in the continuous observation of physical phenomenon plays a significant role in extending the lifetime of WSNs. However, the high redundancy of sensing data leads to great waste of energy as a result of over-deployed sensor nodes. In this paper, we develop a structure fidelity data collection (SFDC) framework leveraging the spatial correlations between nodes to reduce the number of the active sensor nodes while maintaining the low structural distortion of the collected data. A structural distortion based on the image quality assessment approach is used to perform the nodes work/sleep scheduling, such that the number of the working nodes is reduced while the remainder of nodes can be put into the low-power sleep mode during the sampling period. The main contribution of SFDC is to provide a unique perspective on how to maintain the data fidelity in term of structural similarity in the continuous sensing applications for WSNs. The simulation results based on synthetic and real world datasets verify the effectiveness of SFDC framework both on energy saving and data fidelity. PMID:25609045

  4. High-Fidelity Buckling Analysis of Composite Cylinders Using the STAGS Finite Element Code

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.

    2014-01-01

    Results from previous shell buckling studies are presented that illustrate some of the unique and powerful capabilities in the STAGS finite element analysis code that have made it an indispensable tool in structures research at NASA over the past few decades. In particular, prototypical results from the development and validation of high-fidelity buckling simulations are presented for several unstiffened thin-walled compression-loaded graphite-epoxy cylindrical shells along with a discussion on the specific methods and user-defined subroutines in STAGS that are used to carry out the high-fidelity simulations. These simulations accurately account for the effects of geometric shell-wall imperfections, shell-wall thickness variations, local shell-wall ply-gaps associated with the fabrication process, shell-end geometric imperfections, nonuniform applied end loads, and elastic boundary conditions. The analysis procedure uses a combination of nonlinear quasi-static and transient dynamic solution algorithms to predict the prebuckling and unstable collapse response characteristics of the cylinders. Finally, the use of high-fidelity models in the development of analysis-based shell-buckling knockdown (design) factors is demonstrated.

  5. Demonstration of a High-Fidelity Predictive/Preview Display Technique for Telerobotic Servicing in Space

    NASA Technical Reports Server (NTRS)

    Kim, Won S.; Bejczy, Antal K.

    1993-01-01

    A highly effective predictive/preview display technique for telerobotic servicing in space under several seconds communication time delay has been demonstrated on a large laboratory scale in May 1993, involving the Jet Propulsion Laboratory as the simulated ground control station and, 2500 miles away, the Goddard Space Flight Center as the simulated satellite servicing set-up. The technique is based on a high-fidelity calibration procedure that enables a high-fidelity overlay of 3-D graphics robot arm and object models over given 2-D TV camera images of robot arm and objects. To generate robot arm motions, the operator can confidently interact in real time with the graphics models of the robot arm and objects overlaid on an actual camera view of the remote work site. The technique also enables the operator to generate high-fidelity synthetic TV camera views showing motion events that are hidden in a given TV camera view or for which no TV camera views are available. The positioning accuracy achieved by this technique for a zoomed-in camera setting was about +/-5 mm, well within the allowable +/-12 mm error margin at the insertion of a 45 cm long tool in the servicing task.

  6. Becoming a high-fidelity - super - imitator: what are the contributions of social and individual learning?

    PubMed

    Subiaul, Francys; Patterson, Eric M; Schilder, Brian; Renner, Elizabeth; Barr, Rachel

    2015-11-01

    In contrast to other primates, human children's imitation performance goes from low to high fidelity soon after infancy. Are such changes associated with the development of other forms of learning? We addressed this question by testing 215 children (26-59 months) on two social conditions (imitation, emulation) - involving a demonstration - and two asocial conditions (trial-and-error, recall) - involving individual learning - using two touchscreen tasks. The tasks required responding to either three different pictures in a specific picture order (Cognitive: Airplane→Ball→Cow) or three identical pictures in a specific spatial order (Motor-Spatial: Up→Down→Right). There were age-related improvements across all conditions and imitation, emulation and recall performance were significantly better than trial-and-error learning. Generalized linear models demonstrated that motor-spatial imitation fidelity was associated with age and motor-spatial emulation performance, but cognitive imitation fidelity was only associated with age. While this study provides evidence for multiple imitation mechanisms, the development of one of those mechanisms - motor-spatial imitation - may be bootstrapped by the development of another social learning skill - motor-spatial emulation. Together, these findings provide important clues about the development of imitation, which is arguably a distinctive feature of the human species.

  7. Transmission fidelity is the key to the build-up of cumulative culture

    PubMed Central

    Lewis, Hannah M.; Laland, Kevin N.

    2012-01-01

    Many animals have socially transmitted behavioural traditions, but human culture appears unique in that it is cumulative, i.e. human cultural traits increase in diversity and complexity over time. It is often suggested that high-fidelity cultural transmission is necessary for cumulative culture to occur through refinement, a process known as ‘ratcheting’, but this hypothesis has never been formally evaluated. We discuss processes of information transmission and loss of traits from a cognitive viewpoint alongside other cultural processes of novel invention (generation of entirely new traits), modification (refinement of existing traits) and combination (bringing together two established traits to generate a new trait). We develop a simple cultural transmission model that does not assume major evolutionary changes (e.g. in brain architecture) and show that small changes in the fidelity with which information is passed between individuals can lead to cumulative culture. In comparison, modification and combination have a lesser influence on, and novel invention appears unimportant to, the ratcheting process. Our findings support the idea that high-fidelity transmission is the key driver of human cumulative culture, and that progress in cumulative culture depends more on trait combination than novel invention or trait modification. PMID:22734060

  8. High-fidelity self-assembly pathways for hydrogen-bonding molecular semiconductors

    PubMed Central

    Lin, Xu; Suzuki, Mika; Gushiken, Marina; Yamauchi, Mitsuaki; Karatsu, Takashi; Kizaki, Takahiro; Tani, Yuki; Nakayama, Ken-ichi; Suzuki, Mitsuharu; Yamada, Hiroko; Kajitani, Takashi; Fukushima, Takanori; Kikkawa, Yoshihiro; Yagai, Shiki

    2017-01-01

    The design of molecular systems with high-fidelity self-assembly pathways that include several levels of hierarchy is of primary importance for the understanding of structure-function relationships, as well as for controlling the functionality of organic materials. Reported herein is a high-fidelity self-assembly system that comprises two hydrogen-bonding molecular semiconductors with regioisomerically attached short alkyl chains. Despite the availability of both discrete cyclic and polymeric linear hydrogen-bonding motifs, the two regioisomers select one of the two motifs in homogeneous solution as well as at the 2D-confined liquid-solid interface. This selectivity arises from the high directionality of the involved hydrogen-bonding interactions, which renders rerouting to other self-assembly pathways difficult. In thin films and in the bulk, the resulting hydrogen-bonded assemblies further organize into the expected columnar and lamellar higher-order architectures via solution processing. The contrasting organized structures of these regioisomers are reflected in their notably different miscibility with soluble fullerene derivatives in the solid state. Thus, electron donor-acceptor blend films deliver a distinctly different photovoltaic performance, despite their virtually identical intrinsic optoelectronic properties. Currently, we attribute this high-fidelity control via self-assembly pathways to the molecular design of these supramolecular semiconductors, which lacks structure-determining long aliphatic chains. PMID:28225029

  9. High-fidelity self-assembly pathways for hydrogen-bonding molecular semiconductors.

    PubMed

    Lin, Xu; Suzuki, Mika; Gushiken, Marina; Yamauchi, Mitsuaki; Karatsu, Takashi; Kizaki, Takahiro; Tani, Yuki; Nakayama, Ken-Ichi; Suzuki, Mitsuharu; Yamada, Hiroko; Kajitani, Takashi; Fukushima, Takanori; Kikkawa, Yoshihiro; Yagai, Shiki

    2017-02-22

    The design of molecular systems with high-fidelity self-assembly pathways that include several levels of hierarchy is of primary importance for the understanding of structure-function relationships, as well as for controlling the functionality of organic materials. Reported herein is a high-fidelity self-assembly system that comprises two hydrogen-bonding molecular semiconductors with regioisomerically attached short alkyl chains. Despite the availability of both discrete cyclic and polymeric linear hydrogen-bonding motifs, the two regioisomers select one of the two motifs in homogeneous solution as well as at the 2D-confined liquid-solid interface. This selectivity arises from the high directionality of the involved hydrogen-bonding interactions, which renders rerouting to other self-assembly pathways difficult. In thin films and in the bulk, the resulting hydrogen-bonded assemblies further organize into the expected columnar and lamellar higher-order architectures via solution processing. The contrasting organized structures of these regioisomers are reflected in their notably different miscibility with soluble fullerene derivatives in the solid state. Thus, electron donor-acceptor blend films deliver a distinctly different photovoltaic performance, despite their virtually identical intrinsic optoelectronic properties. Currently, we attribute this high-fidelity control via self-assembly pathways to the molecular design of these supramolecular semiconductors, which lacks structure-determining long aliphatic chains.

  10. A Methodology for Evaluating the Fidelity of Ground-Based Flight Simulators

    NASA Technical Reports Server (NTRS)

    Zeyada, Y.; Hess, R. A.

    1999-01-01

    An analytical and experimental investigation was undertaken to model the manner in which pilots perceive and utilize visual, proprioceptive, and vestibular cues in a ground-based flight simulator. The study was part of a larger research effort which has the creation of a methodology for determining flight simulator fidelity requirements as its ultimate goal. The study utilized a closed-loop feedback structure of the pilot/simulator system which included the pilot, the cockpit inceptor, the dynamics of the simulated vehicle and the motion system. With the exception of time delays which accrued in visual scene production in the simulator, visual scene effects were not included in this study. The NASA Ames Vertical Motion Simulator was used in a simple, single-degree of freedom rotorcraft bob-up/down maneuver. Pilot/vehicle analysis and fuzzy-inference identification were employed to study the changes in fidelity which occurred as the characteristics of the motion system were varied over five configurations i The data from three of the five pilots that participated in the experimental study were analyzed in the fuzzy inference identification. Results indicate that both the analytical pilot/vehicle analysis and the fuzzyinference identification can be used to reflect changes in simulator fidelity for the task examined.

  11. Improving fidelity of quantum cloning via the Dzyaloshinskii-Moriya interaction in a spin network

    SciTech Connect

    Chen Yuhan; Zhu Aidong; Shao Xiaoqiang; Yeon, Kyu-Hwang; Yu, Seong-Cho

    2010-03-15

    We investigate the effect of the Dzyaloshinskii-Moriya (DM) interaction on the fidelity of the 1{yields}M phase-covariant cloning machine (PCCM) in a spin star network. The results of numerical calculation show that the DM interaction can further improve the cloning fidelity to reach the optimal value. Furthermore, the physical mechanism is investigated by analyzing the effect of the DM interaction on the populations of the qubits. It is shown that the DM interaction leads to the populations of states |1>|S(M,k+1)> and |1>|S(M,k)>[or |0>|S(M,k)> and |0>|S(M,k-1)>] simultaneously reaching the maximum or minimum value periodically, where the first ket |i> ( is an element of 0,1) in |i>|S(M,k)> denotes the state of central spin with |0> and |1> representing the spin-up and spin-down states, respectively, while the second ket |S(M,k)> denotes the state of outer spins with M being the total number of outer spins and k the number of up spins. At these extreme overlapping points of two states, the fidelity of quantum cloning can reach optimal value. Finally the forms of these two different 1{yields}M optimal cloning transformations are presented.

  12. Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression.

    PubMed

    Musalgaonkar, Sharmishtha; Moomau, Christine A; Dinman, Jonathan D

    2014-12-01

    At equilibrium, empty ribosomes freely transit between the rotated and un-rotated states. In the cell, the binding of two translation elongation factors to the same general region of the ribosome stabilizes one state over the other. These stabilized states are resolved by expenditure of energy in the form of GTP hydrolysis. A prior study employing mutants of a late assembling peripheral ribosomal protein suggested that ribosome rotational status determines its affinity for elongation factors, and hence translational fidelity and gene expression. Here, mutants of the early assembling integral ribosomal protein uL2 are used to test the generality of this hypothesis. rRNA structure probing analyses reveal that mutations in the uL2 B7b bridge region shift the equilibrium toward the rotated state, propagating rRNA structural changes to all of the functional centers of ribosome. Structural disequilibrium unbalances ribosome biochemically: rotated ribosomes favor binding of the eEF2 translocase and disfavor that of the elongation ternary complex. This manifests as specific translational fidelity defects, impacting the expression of genes involved in telomere maintenance. A model is presented describing how cyclic intersubunit rotation ensures the unidirectionality of translational elongation, and how perturbation of rotational equilibrium affects specific aspects of translational fidelity and cellular gene expression.

  13. Fidelity decay and entropy production in many-particle systems after random interaction quench

    NASA Astrophysics Data System (ADS)

    Haldar, Sudip Kumar; Chavda, N. D.; Vyas, Manan; Kota, V. K. B.

    2016-04-01

    We analyze the effect of spin degree of freedom on fidelity decay and entropy production of a many-particle fermionic (bosonic) system in a mean-field, quenched by a random two-body interaction preserving many-particle spin S. The system Hamiltonian is represented by embedded Gaussian orthogonal ensemble (EGOE) of random matrices (for time-reversal and rotationally invariant systems) with one plus two-body interactions preserving S for fermions/bosons. EGOE are paradigmatic models to study the dynamical transition from integrability to chaos in interacting many-body quantum systems. A simple general picture, in which the variances of the eigenvalue density play a central role, is obtained for describing the short-time dynamics of fidelity decay and entropy production. Using some approximations, an EGOE formula for the time (t sat) for the onset of saturation of entropy, is also derived. These analytical EGOE results are in good agreement with numerical calculations. Moreover, both fermion and boson systems show significant spin dependence on the relaxation dynamics of the fidelity and entropy.

  14. Can Inner Experience Be Apprehended in High Fidelity? Examining Brain Activation and Experience from Multiple Perspectives

    PubMed Central

    Hurlburt, Russell T.; Alderson-Day, Ben; Fernyhough, Charles; Kühn, Simone

    2017-01-01

    We discuss the historical context for explorations of “pristine inner experience,” attempts to apprehend and describe the inner experiences that directly present themselves in natural environments. There is no generally accepted method for determining whether such apprehensions/descriptions should be considered high fidelity. By analogy from musical recording, we present and discuss one strategy for establishing experiential fidelity: the examining of brain activation associated with a variety of experiential perspectives that had not been specified at the time of data collection. We beeped participants in an fMRI scanner at randomly-determined times and recorded time-locked brain activations. We used Descriptive Experience Sampling (DES) to apprehend and describe the participant's experience that was ongoing at each beep. These apprehensions/descriptions were obtained with no specific theoretical perspective or experimental intention when originally collected. If these apprehensions/descriptions were of high fidelity, then these pairings of moments of experience and brain activations should be able to be productively examined and re-examined in multiple ways and from multiple theoretical perspectives. We discuss a small set of such re-examinations and conclude that this strategy is worthy of further examination. PMID:28191000

  15. Organizational Culture Shapes the Adoption and Incorporation of Simulation into Nursing Curricula: A Grounded Theory Study

    PubMed Central

    Jack, Susan M.; Eva, Kevin; Martin, Lynn

    2014-01-01

    Purpose. To create a substantive mid-range theory explaining how the organizational cultures of undergraduate nursing programs shape the adoption and incorporation of mid-to high-level technical fidelity simulators as a teaching strategy within curricula. Method. A constructivist grounded theory was used to guide this study which was conducted in Ontario, Canada, during 2011-12. Semistructured interviews (n = 43) with participants that included nursing administrators, nursing faculty, and simulation leaders across multiple programs (n = 13) informed this study. Additionally, key documents (n = 67) were reviewed. Purposeful and theoretical sampling was used and data were collected and analyzed simultaneously. Data were compared among and between sites. Findings. The organizational elements that shape simulation in nursing (OESSN) model depicts five key organizational factors at the nursing program level that shaped the adoption and incorporation of simulation: (1) leaders working in tandem, (2) information exchange, (3) physical locale, (4) shared motivators, and (5) scaffolding to manage change. Conclusions. The OESSN model provides an explanation of the organizational factors that contributed to the adoption and incorporation of simulation into nursing curricula. Nursing programs that use the OESSN model may experience a more rapid or broad uptake of simulation when organizational factors that impact adoption and incorporation are considered and planned for. PMID:24818018

  16. Developing effective serious games: the effect of background sound on visual fidelity perception with varying texture resolution.

    PubMed

    Rojas, David; Kapralos, Bill; Cristancho, Sayra; Collins, Karen; Hogue, Andrew; Conati, Cristina; Dubrowski, Adam

    2012-01-01

    Despite the benefits associated with virtual learning environments and serious games, there are open, fundamental issues regarding simulation fidelity and multi-modal cue interaction and their effect on immersion, transfer of knowledge, and retention. Here we describe the results of a study that examined the effect of ambient (background) sound on the perception of visual fidelity (defined with respect to texture resolution). Results suggest that the perception of visual fidelity is dependent on ambient sound and more specifically, white noise can have detrimental effects on our perception of high quality visuals. The results of this study will guide future studies that will ultimately aid in developing an understanding of the role that fidelity, and multi-modal interactions play with respect to knowledge transfer and retention for users of virtual simulations and serious games.

  17. Influence of age and sex on winter site fidelity of sanderlings Calidris alba

    PubMed Central

    Alves, José A.; Reneerkens, Jeroen; Loonstra, AH Jelle; Potts, Peter M.; Granadeiro, José P.; Catry, Teresa

    2016-01-01

    Many migratory bird species show high levels of site fidelity to their wintering sites, which confers advantages due to prior knowledge, but may also limit the ability of the individual to move away from degrading sites or to detect alternative foraging opportunities. Winter site fidelity often varies among age groups, but sexual differences have seldom been recorded in birds. We studied a population of individually colour-marked sanderlings wintering in and around the Tejo estuary, a large estuarine wetland on the western coast of Portugal. For 160 individuals, sighted a total of 1,249 times between November 2009 and March 2013, we calculated the probability that they moved among five distinct wintering sites and how this probability is affected by distance between them. To compare site fidelity among age classes and sexes, as well as within the same winter and over multiple winters, we used a Site Fidelity Index (SFI). Birds were sexed using a discriminant function based on biometrics of a large set of molecularly sexed sanderlings (n = 990). The vast majority of birds were observed at one site only, and the probability of the few detected movements between sites was negatively correlated with the distance among each pair of sites. Hardly any movements were recorded over more than 15 km, suggesting small home ranges. SFI values indicated that juveniles were less site-faithful than adults which may reflect the accumulated knowledge and/or dominance of older animals. Among adults, females were significantly less site faithful than males. A sexual difference in winter site fidelity is unusual in shorebirds. SFI values show site-faithfulness is lower when multiple winters were considered, and most birds seem to chose a wintering site early in the season and use that site throughout the winter. Sanderlings show a very limited tendency to explore alternative wintering options, which might have implications for their survival when facing habitat change or loss (e

  18. Advances in coupled safety modeling using systems analysis and high-fidelity methods.

    SciTech Connect

    Fanning, T. H.; Thomas, J. W.; Nuclear Engineering Division

    2010-05-31

    The potential for a sodium-cooled fast reactor to survive severe accident initiators with no damage has been demonstrated through whole-plant testing in EBR-II and FFTF. Analysis of the observed natural protective mechanisms suggests that they would be characteristic of a broad range of sodium-cooled fast reactors utilizing metal fuel. However, in order to demonstrate the degree to which new, advanced sodium-cooled fast reactor designs will possess these desired safety features, accurate, high-fidelity, whole-plant dynamics safety simulations will be required. One of the objectives of the advanced safety-modeling component of the Reactor IPSC is to develop a science-based advanced safety simulation capability by utilizing existing safety simulation tools coupled with emerging high-fidelity modeling capabilities in a multi-resolution approach. As part of this integration, an existing whole-plant systems analysis code has been coupled with a high-fidelity computational fluid dynamics code to assess the impact of high-fidelity simulations on safety-related performance. With the coupled capabilities, it is possible to identify critical safety-related phenomenon in advanced reactor designs that cannot be resolved with existing tools. In this report, the impact of coupling is demonstrated by evaluating the conditions of outlet plenum thermal stratification during a protected loss of flow transient. Outlet plenum stratification was anticipated to alter core temperatures and flows predicted during natural circulation conditions. This effect was observed during the simulations. What was not anticipated, however, is the far-reaching impact that resolving thermal stratification has on the whole plant. The high temperatures predicted at the IHX inlet due to thermal stratification in the outlet plenum forces heat into the intermediate system to the point that it eventually becomes a source of heat for the primary system. The results also suggest that flow stagnation in the

  19. Implementing the LifeSkills Training drug prevention program: factors related to implementation fidelity

    PubMed Central

    Mihalic, Sharon F; Fagan, Abigail A; Argamaso, Susanne

    2008-01-01

    Background Widespread replication of effective prevention programs is unlikely to affect the incidence of adolescent delinquency, violent crime, and substance use until the quality of implementation of these programs by community-based organizations can be assured. Methods This paper presents the results of a process evaluation employing qualitative and quantitative methods to assess the extent to which 432 schools in 105 sites implemented the LifeSkills Training (LST) drug prevention program with fidelity. Regression analysis was used to examine factors influencing four dimensions of fidelity: adherence, dosage, quality of delivery, and student responsiveness. Results Although most sites faced common barriers, such as finding room in the school schedule for the program, gaining full support from key participants (i.e., site coordinators, principals, and LST teachers), ensuring teacher participation in training workshops, and classroom management difficulties, most schools involved in the project implemented LST with very high levels of fidelity. Across sites, 86% of program objectives and activities required in the three-year curriculum were delivered to students. Moreover, teachers were observed using all four recommended teaching practices, and 71% of instructors taught all the required LST lessons. Multivariate analyses found that highly rated LST program characteristics and better student behavior were significantly related to a greater proportion of material taught by teachers (adherence). Instructors who rated the LST program characteristics as ideal were more likely to teach all lessons (dosage). Student behavior and use of interactive teaching techniques (quality of delivery) were positively related. No variables were related to student participation (student responsiveness). Conclusion Although difficult, high implementation fidelity by community-based organizations can be achieved. This study suggests some important factors that organizations should

  20. High-fidelity frequency down-conversion of visible entangled photon pairs with superconducting single-photon detectors

    SciTech Connect

    Ikuta, Rikizo; Kato, Hiroshi; Kusaka, Yoshiaki; Yamamoto, Takashi; Imoto, Nobuyuki; Miki, Shigehito; Yamashita, Taro; Terai, Hirotaka; Wang, Zhen; Fujiwara, Mikio; Sasaki, Masahide; Koashi, Masato

    2014-12-04

    We experimentally demonstrate a high-fidelity visible-to-telecommunicationwavelength conversion of a photon by using a solid-state-based difference frequency generation. In the experiment, one half of a pico-second visible entangled photon pair at 780 nm is converted to a 1522-nm photon. Using superconducting single-photon detectors with low dark count rates and small timing jitters, we observed a fidelity of 0.93±0.04 after the wavelength conversion.