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Sample records for 16-18 year olds

  1. The Use of Ethical Frameworks by Students Following a New Science Course for 16-18 Year-Olds

    ERIC Educational Resources Information Center

    Reiss, Michael

    2008-01-01

    There has been a move in recent years towards the greater inclusion of social and ethical issues within science courses. This paper examines a new context-based course for 16-18 year-olds (Salters-Nuffield Advanced Biology) who are studying biology in England and Wales. The course is taught through contexts and has an emphasis on social issues and…

  2. Immunogenicity of the Quadrivalent Human Papillomavirus (Type 6/11/16/18) Vaccine in Males 16 to 26 Years Old

    PubMed Central

    Giuliano, Anna R.; Palefsky, Joel M.; Goldstone, Stephen; Moreira, Edson D.; Vardas, Eftyhia; Aranda, Carlos; Jessen, Heiko; Ferris, Daron G.; Coutlee, Francois; Marshall, J. Brooke; Vuocolo, Scott; Haupt, Richard M.; Guris, Dalya; Garner, Elizabeth I. O.

    2012-01-01

    Human papillomavirus (HPV) infection can lead to significant disease in males, including anogenital warts, intraepithelial neoplasias, and several types of oral and anogenital cancers. The quadrivalent HPV (type 6/11/16/18) L1 virus-like particle (VLP) vaccine (qHPV vaccine; Gardasil) has recently been demonstrated to prevent persistent infection and associated disease related to vaccine HPV types in males. We report the overall immunogenicity results from a trial of the quadrivalent HPV vaccine in males. Overall, 3,463 heterosexual men and 602 men who had sex with men were enrolled into a randomized, placebo-controlled, double-blind safety, immunogenicity, and efficacy study. Serum samples were collected prior to vaccination at day 1 and at months 7, 24, and 36 postvaccination. Immunogenicity was evaluated with a multiplex, competitive Luminex immunoassay. Almost all subjects (97.4 to 99.2%) seroconverted for vaccine HPV types by month 7. At month 36, 88.9%, 94.0%, 97.9%, and 57.0% of subjects were still seropositive for HPV-6, -11, -16, and -18, respectively. For all vaccine HPV types, black subjects had significantly higher antibody titers at month 7 than did both Caucasian and Asian subjects. An anamnestic antibody response was seen in men seropositive before vaccination. The vaccine was highly immunogenic in males 16 to 23 years of age; responses were comparable to those observed in women. Furthermore, the immune responses were consistent with the established efficacy of the vaccine in the prevention of incident and persistent HPV infection, anogenital warts, and anal intraepithelial neoplasia. PMID:22155768

  3. What Do Employers Want from Education: An Employer Survey of 16-18 Year Olds in the Thames Valley.

    ERIC Educational Resources Information Center

    Hawe, J. Michael, Comp.

    A survey investigated what employers in the Thames Valley, England, were looking for in their recruitment of young people aged 16-18. Of 600 companies, 37 percent responded. Twenty percent did not recruit at that age level; 76 percent required two advanced ("A") levels and Pass grades. Recruitment of young people with a General…

  4. The national vocational education plan for unqualified young people (16?18 years old): The French experience (1982?1984)

    NASA Astrophysics Data System (ADS)

    Colardyn, Danielle; Malglaive, Gerard

    1986-12-01

    In 1982, the French Government instituted a new National Vocational Education Plan (NVEP) to combat the nationwide problem of students leaving the school system prior to receiving adequate vocational preparation. This plan affects 100,000 young people between the ages of 16 and 18 years. The NVEP gave to each Regional Government the opportunity to create its own programmes and curricula; it renewed counselling and individual assessment facilities; it established new tracks within the education system; it also established co-operative education (linking education to the world of work). Concurrently, an Assessment and Observation System was created. During the first assessment year (1982-1983), information was gathered about existing local educational resources, counselling facilities, characteristics of the 16 to 18 year-old population, functioning of the educational tracks and co-operative education system. During the second year (1983-1984), the assessment provided quantitative statistical results. The most striking result concerns the configurations of educational and employment experiences which seemed to determine the ability of students to find employment. Students with a background of `job intensive experiences' were more successful in finding subsequent employment than those without. Students with `education intensive experiences' entered an educational programme because they were unable to find a first job. While the benefits of the NVEP were not immediately apparent, it nevertheless became evident that at this level of training, education was not necessarily the royal road to employment. However, employment criteria cannot be the only way to assess a vocational education system.

  5. [Evaluation of selected features of the lifestyle being conducive to the state of health of 16-18 year old girls. Part II. Nutritional habits].

    PubMed

    Piotrowska, Ewa; Zechałko-Czajkowska, Alicja; Biernat, Jadwiga; Mikołajczak, Jolanta

    2009-01-01

    The aim of the study was to analyze nutritional habits of 409 16-18 year old girls from Wrocław. They are one of three elements shaping health attitude of girls. This research indicates mostly committing nutritional mistakes of the girls e.g.: irregularity of meals consumption 73% of girls, incorrect number of meals about 60% of girls, omission of breakfast about 15% of girls and lunch 20% of girls, movement of main meal up to late evening and night hours, and regular snaking meals 53.0% of girls.

  6. [Assessment of selected features of the lifestyle being conduicive to the state of health of 16-18 year old girls. Part I. Dieting, physical activity, smoking and drinking alcohol].

    PubMed

    Piotrowska, Ewa; Zechałko-Czajkowska, Alicja; Biernat, Jadwiga; Mikołajczak, Jolanta

    2009-01-01

    The aim of the study was to analyze health attitude of 409 16-18 year old girls from Wrocław in three areas: physical activity, dieting, and smoking and alcohol use. Research indicated different levels of underweight among 17.4% of girls, overweight and obesity among 11.2% of girls, and inappropriate level of physical activity among 60% of girls. Negative self-evaluation of own appearance among 50% of girls contributed to dieting among 32% of girls. Studies indicated as well that 49% of girls smoke, and 89% of girls drink alcohol occasionally or every week.

  7. Risk of new onset autoimmune disease in 9- to 25-year-old women exposed to human papillomavirus-16/18 AS04-adjuvanted vaccine in the United Kingdom

    PubMed Central

    Willame, Corinne; Rosillon, Dominique; Zima, Julia; Angelo, Maria-Genalin; Stuurman, Anke L.; Vroling, Hilde; Boggon, Rachael; Bunge, Eveline M.; Pladevall-Vila, Manel; Baril, Laurence

    2016-01-01

    ABSTRACT To assess the risk of autoimmune disease (AD) in 9–25 year-old women within 1 year after the first AS04-HPV-16/18vaccine dose, a retrospective, observational database cohort study was conducted using CPRD GOLD. From CPRD GOLD 4 cohorts (65,000 subjects each) were retrieved: 1 exposed female cohort (received ≥1 AS04-HPV-16/18 vaccine dose between Sep2008–Aug2010) and 3 unexposed cohorts: historical female (Sep2005–Aug2007), concurrent male, and historical male. Co-primary endpoints were confirmed neuroinflammatory/ophthalmic AD and other AD, secondary endpoints were confirmed individual AD. Risk of new onset of AD was compared between cohorts (reference: historical cohort) using Poisson regression. The main analysis using confirmed cases showed no neuroinflammatory/ophthalmic AD cases in the female exposed cohort. Incidence rate ratio (IRR) (95% CI) of other AD was 1.41 (0.86 to 2.31) in female and 1.77 (0.94 to 3.35) in male cohorts when compared to the female and male historical cohort, respectively. Secondary endpoints were evaluated for diseases with >10 cases, which were Crohn's disease (IRR: 1.21 [0.37 to 3.95] for female and 4.22 [0.47 to 38.02] for male cohorts), autoimmune thyroiditis (IRR: 3.75 [1.25 to 11.31] for female and no confirmed cases for male cohorts) and type 1 diabetes (IRR: 0.30 [0.11 to 0.83] for female and 2.46 [1.08 to 5.60] for male cohorts). Analysis using confirmed and non-confirmed cases showed similar results, except for autoimmune thyroiditis in females, IRR: 1.45 (0.79 to 2.64). There was no evidence of an increased risk of AD in women aged 9 to 25 years after AS04-HPV-16/18 vaccination. PMID:27428517

  8. Early intervention for depression and anxiety in 16-18-year-olds: Protocol for a feasibility cluster randomised controlled trial of open-access psychological workshops in schools (DISCOVER).

    PubMed

    Michelson, Daniel; Sclare, Irene; Stahl, Daniel; Morant, Nicola; Bonin, Eva-Maria; Brown, June S L

    2016-05-01

    Adolescence is a vulnerable period for the development of mental health problems. The DISCOVER intervention aims to provide accessible, acceptable and cost-effective psychological support for stressed adolescents in inner-city secondary schools. The intervention uses age-appropriate cognitive-behavioural therapy (CBT) methods and materials, delivered in an interactive 1-day workshop with additional telephone support. An open-access entry route allows students to self-refer. This protocol describes a feasibility cluster randomised controlled trial (RCT) comparing DISCOVER with a waitlist control condition. The study will run across 10 clusters (secondary schools) in the inner London Boroughs of Southwark and Lambeth. Participants are students aged over 16years who are seeking help with anxiety and/or depressive symptoms. Key feasibility parameters relate to the proportion of students willing to participate in the research following publicity events; the proportion of students who complete the intervention; and response rates for outcome measures. Outcome variance estimates and intra-cluster correlations will be obtained for future power calculations. Qualitative methods will be used to explore the acceptability of the intervention and research procedures for students and school staff. The feasibility of an economic evaluation will also be examined. The results will (i) determine the appropriateness of proceeding to a definitive full-scale trial; and (ii) inform the development of an optimised version of the DISCOVER intervention that can be tested within feasible parameters.

  9. Understanding the Idea of Chemical Elements and Their Periodic Classification in Spanish Students Aged 16-18 Years

    ERIC Educational Resources Information Center

    Franco-Mariscal, Antonio-Joaquín; Oliva-Martínez, José María; Almoraima Gil, M. L.

    2016-01-01

    The work reported here involved a comparative study regarding the understanding that high school students (16-18 years) have of the concept of chemical elements and their periodic classification. More specifically, the level of knowledge on this topic was compared before and after the completion of baccalaureate studies in a sample of Spanish…

  10. End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age

    PubMed Central

    Castellsagué, X; Muñoz, N; Pitisuttithum, P; Ferris, D; Monsonego, J; Ault, K; Luna, J; Myers, E; Mallary, S; Bautista, O M; Bryan, J; Vuocolo, S; Haupt, R M; Saah, A

    2011-01-01

    Background: Previous analyses from a randomised trial in women aged 24–45 years have shown the quadrivalent human papillomavirus (qHPV) vaccine to be efficacious in the prevention of infection, cervical intraepithelial neoplasia (CIN), and external genital lesions (EGLs) related to HPV 6/11/16/18. In this report, we present end-of-study efficacy, safety, and immunogenicity data with a median follow-up time of 4.0 years. Methods: We enrolled 3819 24–45-year-old women with no history of cervical disease or genital warts in the past 5 years. Women received quadrivalent vaccine or placebo at day 1, and at months 2 and 6. Ascertainment of CIN/EGL was accomplished through Pap testing, genital inspection, and cervicovaginal sampling (every 6 months). The main analysis was conducted in a per-protocol efficacy population (that received three doses, was naive to the relevant HPV types at day 1, and remained free of infection through month 7). Efficacy was also estimated in other naive and non-naive populations. Results: Vaccine efficacy against the combined incidence of persistent infection, CIN/EGL related to HPV6/11/16/18 in the per-protocol population was 88.7% (95% CI: 78.1, 94.8). Efficacy for women who were seropositive and DNA negative for the relevant vaccine HPV type at the time of enrolment who received at least 1 dose was 66.9% (95% CI: 4.3, 90.6). At month 48, 91.5, 92.0, 97.4, and 47.9% of vaccinated women were seropositive to HPV 6/11/16/18, respectively. No serious vaccine-related adverse experiences were reported. Conclusions: The qHPV vaccine demonstrated high efficacy, immunogenicity, and acceptable safety in women aged 24–45 years, regardless of previous exposure to HPV vaccine type. PMID:21629249

  11. Significantly Reduced Genoprevalence of Vaccine-Type HPV-16/18 Infections among Vaccinated Compared to Non-Vaccinated Young Women 5.5 Years after a Bivalent HPV-16/18 Vaccine (Cervarix®) Pilot Project in Uganda

    PubMed Central

    Berggren, Vanja; Wabinga, Henry; Lillsunde-Larsson, Gabriella; Helenius, Gisela; Kaliff, Malin; Karlsson, Mats; Kirimunda, Samuel; Musubika, Caroline; Andersson, Sören

    2016-01-01

    The objective of this study was to determine the prevalence and some predictors for vaccine and non-vaccine types of HPV infections among bivalent HPV vaccinated and non-vaccinated young women in Uganda. This was a comparative cross sectional study 5.5 years after a bivalent HPV 16/18 vaccination (Cervarix®, GlaxoSmithKline, Belgium) pilot project in western Uganda. Cervical swabs were collected between July 2014-August 2014 and analyzed with a HPV genotyping test, CLART® HPV2 assay (Genomica, Madrid Spain) which is based on PCR followed by microarray for determination of genotype. Blood samples were also tested for HIV and syphilis infections as well as CD4 and CD8 lymphocyte levels. The age range of the participants was 15–24 years and mean age was 18.6(SD 1.4). Vaccine-type HPV-16/18 strains were significantly less prevalent among vaccinated women compared to non-vaccinated women (0.5% vs 5.6%, p 0.006, OR 95% CI 0.08(0.01–0.64). At type-specific level, significant difference was observed for HPV16 only. Other STIs (HIV/syphilis) were important risk factors for HPV infections including both vaccine types and non-vaccine types. In addition, for non-vaccine HPV types, living in an urban area, having a low BMI, low CD4 count and having had a high number of life time sexual partners were also significant risk factors. Our data concurs with the existing literature from other parts of the world regarding the effectiveness of bivalent HPV-16/18 vaccine in reducing the prevalence of HPV infections particularly vaccine HPV- 16/18 strains among vaccinated women. This study reinforces the recommendation to vaccinate young girls before sexual debut and integrate other STI particularly HIV and syphilis interventions into HPV vaccination packages. PMID:27482705

  12. Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese girls and women aged 9 to 45 years.

    PubMed

    Zhu, Fengcai; Li, Juan; Hu, Yuemei; Zhang, Xiang; Yang, Xiaoping; Zhao, Hui; Wang, Junzhi; Yang, Jianguo; Xia, Guodong; Dai, Qinyong; Tang, Haiwen; Suryakiran, Pemmaraju; Datta, Sanjoy K; Descamps, Dominique; Bi, Dan; Struyf, Frank

    2014-01-01

    Immunogenicity and safety of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine were evaluated in healthy Chinese females aged 9-45 years in 2 phase IIIB, randomized, controlled trials. Girls aged 9-17 years (ClinicalTrials.gov, NCT00996125) received vaccine (n = 374) or control (n = 376) and women aged 26-45 years (NCT01277042) received vaccine (n = 606) or control (n = 606) at months 0, 1, and 6. The primary objective was to show non-inferiority of anti-HPV-16 and -18 immune responses in initially seronegative subjects at month 7, compared with Chinese women aged 18-25 years enrolled in a separate phase II/III trial (NCT00779766). Secondary objectives were to describe the anti-HPV-16 and -18 immune response, reactogenicity and safety. At month 7, immune responses were non-inferior for girls (9-17 years) vs. young women (18-25 years): the upper limit of the 95% confidence interval (CI) for the geometric mean titer (GMT) ratio (women/girls) was below the limit of 2 for both anti-HPV-16 (0.37 [95% CI: 0.32, 0.43]) and anti-HPV-18 (0.42 [0.36, 0.49]). Immune responses at month 7 were also non-inferior for 26-45 year-old women vs. 18-25 year-old women: the upper limit of the 95% CI for the difference in seroconversion (18-25 minus 26-45) was below the limit of 5% for both anti-HPV-16 (0.00% [-1.53, 1.10]) and anti-HPV-18 (0.21% [-1.36, 1.68]). GMTs were 2- to 3-fold higher in girls (9-17 years) as compared with young women (18-25 years). The HPV-16/18 AS04-adjuvanted vaccine had an acceptable safety profile when administered to healthy Chinese females aged 9-45 years.

  13. Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese girls and women aged 9 to 45 years

    PubMed Central

    Zhu, Fengcai; Li, Juan; Hu, Yuemei; Zhang, Xiang; Yang, Xiaoping; Zhao, Hui; Wang, Junzhi; Yang, Jianguo; Xia, Guodong; Dai, Qinyong; Tang, Haiwen; V Suryakiran, Pemmaraju; Datta, Sanjoy K; Descamps, Dominique; Bi, Dan; Struyf, Frank

    2014-01-01

    Immunogenicity and safety of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine were evaluated in healthy Chinese females aged 9–45 years in 2 phase IIIB, randomized, controlled trials. Girls aged 9–17 years (ClinicalTrials.gov, NCT00996125) received vaccine (n = 374) or control (n = 376) and women aged 26–45 years (NCT01277042) received vaccine (n = 606) or control (n = 606) at months 0, 1, and 6. The primary objective was to show non-inferiority of anti-HPV-16 and -18 immune responses in initially seronegative subjects at month 7, compared with Chinese women aged 18–25 years enrolled in a separate phase II/III trial (NCT00779766). Secondary objectives were to describe the anti-HPV-16 and -18 immune response, reactogenicity and safety. At month 7, immune responses were non-inferior for girls (9–17 years) vs. young women (18–25 years): the upper limit of the 95% confidence interval (CI) for the geometric mean titer (GMT) ratio (women/girls) was below the limit of 2 for both anti-HPV-16 (0.37 [95% CI: 0.32, 0.43]) and anti-HPV-18 (0.42 [0.36, 0.49]). Immune responses at month 7 were also non-inferior for 26–45 year-old women vs. 18–25 year-old women: the upper limit of the 95% CI for the difference in seroconversion (18–25 minus 26–45) was below the limit of 5% for both anti-HPV-16 (0.00% [–1.53, 1.10]) and anti-HPV-18 (0.21% [–1.36, 1.68]). GMTs were 2- to 3-fold higher in girls (9–17 years) as compared with young women (18–25 years). The HPV-16/18 AS04-adjuvanted vaccine had an acceptable safety profile when administered to healthy Chinese females aged 9–45 years. PMID:25424785

  14. Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9-14 years: Results to month 12 from a randomized trial.

    PubMed

    Leung, Ting Fan; Liu, Anthony Pak-Yin; Lim, Fong Seng; Thollot, Franck; Oh, Helen May Lin; Lee, Bee Wah; Rombo, Lars; Tan, Ngiap Chuan; Rouzier, Roman; Friel, Damien; De Muynck, Benoit; De Simoni, Stéphanie; Suryakiran, Pemmaraju; Hezareh, Marjan; Folschweiller, Nicolas; Thomas, Florence; Struyf, Frank

    2015-01-01

    This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9-14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6 (N = 358) or HPV-6/11/16/18(3D) at M0,2,6 (N = 358). The primary objective was non-inferiority/superiority of HPV-16/18 antibodies by ELISA for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) at M7 in the according-to-protocol immunogenicity cohort (ATP-I) and total vaccinated cohort, respectively. Secondary objectives included non-inferiority/superiority of HPV-16/18(2D) vs. HPV-6/11/16/18(3D) at M7, non-inferiority/superiority at M12, HPV-16/18 neutralizing antibodies, frequencies of T-cells/B-cells, reactogenicity and safety. Antibody responses at M7 for HPV-16/18(2D) were superior to those for HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) (lower limit of 95% confidence interval for geometric mean titer ratio (GMR) was >1): HPV-16/18(2D)/HPV-6/11/16/18(2D) GMRs were 1.69 [1.49-1.91] for anti-HPV-16 and 4.52 [3.97-5.13] for anti-HPV-18; HPV-16/18(2D)/HPV-6/11/16/18(3D) GMRs were 1.72 [1.54-1.93] for anti-HPV-16 and 3.22 [2.82-3.68] for anti-HPV-18; p = 0.0001 for all comparisons. Non-inferiority/superiority was also demonstrated at M12. Among initially seronegative girls in the ATP-I, neutralizing antibody titers were at least 1.8-fold higher for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) at M7 and M12. Frequencies of HPV-16/18-specific T-cells and B-cells were in similar ranges between groups. Reactogenicity and safety were in line with the known profile of each vaccine. In conclusion, superior HPV-16/18 antibody responses were elicited by 2 doses of the HPV-16/18 AS04-adjuvanted vaccine compared with 2 or 3 doses of the HPV-6/11/16/18 vaccine in girls (9-14 years).

  15. Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial

    PubMed Central

    Leung, Ting Fan; Liu, Anthony Pak-Yin; Lim, Fong Seng; Thollot, Franck; Oh, Helen May Lin; Lee, Bee Wah; Rombo, Lars; Tan, Ngiap Chuan; Rouzier, Roman; Friel, Damien; De Muynck, Benoit; De Simoni, Stéphanie; Suryakiran, Pemmaraju; Hezareh, Marjan; Folschweiller, Nicolas; Thomas, Florence; Struyf, Frank

    2015-01-01

    This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9–14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6 (N = 358) or HPV-6/11/16/18(3D) at M0,2,6 (N = 358). The primary objective was non-inferiority/superiority of HPV-16/18 antibodies by ELISA for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) at M7 in the according-to-protocol immunogenicity cohort (ATP-I) and total vaccinated cohort, respectively. Secondary objectives included non-inferiority/superiority of HPV-16/18(2D) vs. HPV-6/11/16/18(3D) at M7, non-inferiority/superiority at M12, HPV-16/18 neutralizing antibodies, frequencies of T-cells/B-cells, reactogenicity and safety. Antibody responses at M7 for HPV-16/18(2D) were superior to those for HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) (lower limit of 95% confidence interval for geometric mean titer ratio (GMR) was >1): HPV-16/18(2D)/HPV-6/11/16/18(2D) GMRs were 1.69 [1.49–1.91] for anti-HPV-16 and 4.52 [3.97–5.13] for anti-HPV-18; HPV-16/18(2D)/HPV-6/11/16/18(3D) GMRs were 1.72 [1.54–1.93] for anti-HPV-16 and 3.22 [2.82–3.68] for anti-HPV-18; p = 0.0001 for all comparisons. Non-inferiority/superiority was also demonstrated at M12. Among initially seronegative girls in the ATP-I, neutralizing antibody titers were at least 1.8-fold higher for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) at M7 and M12. Frequencies of HPV-16/18-specific T-cells and B-cells were in similar ranges between groups. Reactogenicity and safety were in line with the known profile of each vaccine. In conclusion, superior HPV-16/18 antibody responses were elicited by 2 doses of the HPV-16/18 AS04-adjuvanted vaccine compared with 2 or 3 doses of the HPV-6/11/16/18 vaccine in girls (9–14

  16. Efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine in Chinese women aged 18-25 years: event-triggered analysis of a randomized controlled trial.

    PubMed

    Zhu, Feng-Cai; Hu, Shang-Ying; Hong, Ying; Hu, Yue-Mei; Zhang, Xun; Zhang, Yi-Ju; Pan, Qin-Jing; Zhang, Wen-Hua; Zhao, Fang-Hui; Zhang, Cheng-Fu; Yang, Xiaoping; Yu, Jia-Xi; Zhu, Jiahong; Zhu, Yejiang; Chen, Feng; Zhang, Qian; Wang, Hong; Wang, Changrong; Bi, Jun; Xue, Shiyin; Shen, Lingling; Zhang, Yan-Shu; He, Yunkun; Tang, Haiwen; Karkada, Naveen; Suryakiran, Pemmaraju; Bi, Dan; Struyf, Frank

    2017-01-01

    We previously reported the results of a phase II/III, double-blind, randomized controlled study in Chinese women (NCT00779766) showing a 94.2% (95% confidence interval: 62.7-99.9) HPV-16/18 AS04-adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6-month (M) persistent infection (PI) with a mean follow-up of <2 years, and immunogenicity until 7 months post-dose 1. Here, we report efficacy and safety results from an event-triggered analysis with ~3 years longer follow-up, and immunogenicity until M24. Healthy 18-25-year-old women (N = 6051) were randomized (1:1) to receive three doses of HPV-16/18 vaccine or Al(OH)3 (control) at M0, 1, 6. VE against HPV-16/18-associated CIN2+, and cross-protective VE against infections with nonvaccine oncogenic HPV types, immunogenicity, and safety were assessed. In the according-to-protocol efficacy cohort, in initially seronegative/DNA-negative women (vaccine group: N = 2524; control group: N = 2535), VE against HPV-16/18-associated CIN2+ was 87.3% (5.3-99.7); VE against incident infection or against 6-month persistent infection associated with HPV-31/33/45 was 50.1% (34.3-62.3) or 52.6% (24.5-70.9), respectively. At least, 99.6% of HPV-16/18-vaccines remained seropositive for anti-HPV-16/18 antibodies; anti-HPV-16 and -18 geometric mean titers were 1271.1 EU/mL (1135.8-1422.6) and 710.0 EU/ml (628.6-801.9), respectively. Serious adverse events were infrequent (1.7% vaccine group [N = 3026]; 2.5% control group [N = 3026]). Of the 1595 reported pregnancies, nine had congenital anomalies (five live infants, three elective terminations, one stillbirth) that were unlikely vaccination-related (blinded data). VE against HPV-16/18-associated CIN2+ was demonstrated and evidence of cross-protective VE against oncogenic HPV types was shown. The vaccine was immunogenic and had an acceptable safety profile.

  17. Impact of vaccination with Cervarix (trade mark) on subsequent HPV-16/18 infection and cervical disease in women 15-25 years of age.

    PubMed

    Harper, Diane M

    2008-09-01

    Cervical cancer of both squamous and adenocarcinoma types is considered virtually 100% attributable to human papillomavirus (HPV) infection. HPV-16 and -18 are the predominant types worldwide accounting for over 70% of all cervical cancer. Persistent oncogenic HPV infection has been confirmed as one key determinant in the development of cervical precancer (cervical intraepithelial neoplasia [CIN] 2+) and cervical cancer. The impact of prophylactic HPV vaccination on the reduction of virological and cytohistological outcomes related to HPV-16 and -18 has been evaluated in clinical trials with the HPV-16/18 AS04-adjuvanted cervical cancer vaccine (Cervarixtrade mark) through a Phase IIb study with a long-term follow-up of efficacy up to 5.5 years, and a large Phase III trial in women 15-25 years of age. These individual studies include populations with different underlying risk factors, each of which shows high efficacy against both HPV-16/18 persistent infections and CIN2+. When the two studies are combined and the respective populations are evaluated, vaccine efficacy against HPV-16 and -18-related CIN2+ remains at 100%. As this vaccine is used over time in universal prophylactic HPV-16/18 vaccination of girls and women, reductions in cervical cancers at both the individual and public health levels will be appreciated.

  18. Immune response to the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose or 3-dose schedule up to 4 years after vaccination

    PubMed Central

    Romanowski, Barbara; Schwarz, Tino F; Ferguson, Linda M; Ferguson, Murdo; Peters, Klaus; Dionne, Marc; Schulze, Karin; Ramjattan, Brian; Hillemanns, Peter; Behre, Ulrich; Suryakiran, Pemmaraju; Thomas, Florence; Struyf, Frank

    2014-01-01

    This randomized, partially-blind study (ClinicalTrials.gov registration number NCT00541970) evaluated the immunogenicity and safety of 2-dose (2D) schedules of the HPV-16/18 AS04-adjuvanted vaccine. Results to month (M) 24 have been reported previously and we now report data to M48 focusing on the licensed vaccine formulation (20 μg each of HPV-16 and -18 antigens) administered at M0,6 compared with the standard 3-dose (3D) schedule (M0,1,6). Healthy females (age stratified: 9–14, 15–19, 20–25 years) were randomized to receive 2D at M0,6 (n = 240) or 3D at M0,1,6 (n = 239). In the according-to-protocol immunogenicity cohort, all initially seronegative subjects seroconverted for HPV-16 and -18 antibodies and remained seropositive up to M48. For both HPV-16 and -18, geometric mean antibody titer (GMT) ratios (3D schedule in women aged 15–25 years divided by 2D schedule in girls aged 9–14 years) at M36 and M48 were close to 1, as they were at M7 when non-inferiority was demonstrated. The kinetics of HPV-16, -18, -31, and -45 antibody responses were similar for both groups and HPV-16 and -18 GMTs were substantially higher than natural infection titers. The vaccine had a clinically acceptable safety profile in both groups. In summary, antibody responses to a 2D M0,6 schedule of the licensed vaccine formulation in girls aged 9–14 years appeared comparable to the standard 3D schedule in women aged 15–25 years up to 4 years after first vaccination. A 2D schedule could facilitate implementation of HPV vaccination programs and improve vaccine coverage and series completion rates. PMID:24576907

  19. Sleep problems and depression in adolescence: results from a large population-based study of Norwegian adolescents aged 16-18 years.

    PubMed

    Sivertsen, Børge; Harvey, Allison G; Lundervold, Astri J; Hysing, Mari

    2014-08-01

    Both sleep problems and depression are common problems in adolescence, but well-defined large epidemiological studies on the relationship are missing in this age group. The aim of this study was to examine the association between depression and several sleep parameters, including insomnia, in a population-based study of adolescents aged 16-18 years, and to explore potential gender differences. A large population-based study in Hordaland County in Norway conducted in 2012, the ung@hordaland study, surveyed 10,220 adolescents aged 16-18 years (54% girls) about sleep and depression. The sleep assessment included measures of the basic sleep parameters for weekdays and weekends. Depression was defined as scoring above the 90th percentile on the total score of Short Moods and Feelings Questionnaire (SMFQ). There was a large overlap between insomnia and depression in both genders and across depressive symptoms. Depressed adolescents exhibited significantly shorter sleep duration and time in bed as well as significantly longer sleep onset latency (SOL) and wake after sleep onset (WASO). Adolescents with insomnia had a 4- to 5-fold increased odds of depression compared to good sleepers. There was also a significant interaction between insomnia, sleep duration and depression, with a more than eightfold increase in odds of depression for those who met criteria for insomnia and who slept <6 h. These associations held for both genders, but were stronger in boys. To the best of our knowledge, this is the first population-based study to investigate sleep and insomnia in relation to depression among adolescents. The findings call for increased awareness of sleep problems and depression as a major public health issue.

  20. Randomized Open Trial Comparing 2-Dose Regimens of the Human Papillomavirus 16/18 AS04-Adjuvanted Vaccine in Girls Aged 9–14 Years Versus a 3-Dose Regimen in Women Aged 15–25 Years

    PubMed Central

    Puthanakit, Thanyawee; Huang, Li-Min; Chiu, Cheng-Hsun; Tang, Ren-Bin; Schwarz, Tino F.; Esposito, Susanna; Frenette, Louise; Giaquinto, Carlo; McNeil, Shelly; Rheault, Paul; Durando, Paolo; Horn, Michael; Klar, Maximilian; Poncelet, Sylviane; De Simoni, Stéphanie; Friel, Damien; De Muynck, Benoit; Suryakiran, Pemmaraju V.; Hezareh, Marjan; Descamps, Dominique; Thomas, Florence; Struyf, Frank

    2016-01-01

    Background. This randomized, open trial compared regimens including 2 doses (2D) of human papillomavirus (HPV) 16/18 AS04-adjuvanted vaccine in girls aged 9–14 years with one including 3 doses (3D) in women aged 15–25 years. Methods. Girls aged 9–14 years were randomized to receive 2D at months 0 and 6 (M0,6; (n = 550) or months 0 and 12 (M0,12; n = 415), and women aged 15–25 years received 3D at months 0, 1, and 6 (n = 482). End points included noninferiority of HPV-16/18 antibodies by enzyme-linked immunosorbent assay for 2D (M0,6) versus 3D (primary), 2D (M0,12) versus 3D, and 2D (M0,6) versus 2D (M0,12); neutralizing antibodies; cell-mediated immunity; reactogenicity; and safety. Limits of noninferiority were predefined as <5% difference in seroconversion rate and <2-fold difference in geometric mean antibody titer ratio. Results. One month after the last dose, both 2D regimens in girls aged 9–14 years were noninferior to 3D in women aged 15–25 years and 2D (M0,12) was noninferior to 2D (M0,6). Geometric mean antibody titer ratios (3D/2D) for HPV-16 and HPV-18 were 1.09 (95% confidence interval, .97–1.22) and 0.85 (.76–.95) for 2D (M0,6) versus 3D and 0.89 (.79–1.01) and 0.75 (.67–.85) for 2D (M0,12) versus 3D. The safety profile was clinically acceptable in all groups. Conclusions. The 2D regimens for the HPV-16/18 AS04-adjuvanted vaccine in girls aged 9–14 years (M0,6 or M0,12) elicited HPV-16/18 immune responses that were noninferior to 3D in women aged 15–25 years. Clinical Trials Registration. NCT01381575. PMID:26908726

  1. OCCUPATIONAL TRAINING CENTERS FOR 16-18 YEAR-OLD YOUTH. A DEMONSTRATION PROGRAM FOR POTENTIAL OR ACTUAL DROPOUTS.

    ERIC Educational Resources Information Center

    KAPLAN, LEON L.

    A SURVEY WAS CONDUCTED TO ASCERTAIN NECESSARY PROCEDURES FOR ESTABLISHING WORK-STUDY PROGRAMS FOR ACTUAL OR POTENTIAL DROPOUTS, AGES 16 AND 17, IN THE LOS ANGELES UNIFIED SCHOOL DISTRICT. THIS SURVEY WAS MADE TO HELP PROVIDE MEANS TO MEET THE CALIFORNIA EDUCATION CODE REQUIREMENTS FOR COMPULSORY CONTINUATION EDUCATION. THE STUDY DETERMINED THAT…

  2. New year, old hat

    NASA Astrophysics Data System (ADS)

    American Geological Institute; American Institute of Physics; American Associationthe Advancement of Science; Carlowicz, Michael

    It is only August, but October 1 looms large on the calendar. That is the day when the 1997 fiscal year (FY ‧97) begins for the U.S. federal government, and like last year, that day might come without a budget.In a flurry of summer activity, the U.S. Congress has passed several landmark bills on welfare reform, expansion of health coverage for workers between jobs, a raise in the minimum wage, and a Safe Drinking Water Act. The House of Representatives even passed all 13 of its annual appropriations bills before Congress took its August recess.

  3. Emotional Development: 2 Year Olds

    MedlinePlus

    ... Español Text Size Email Print Share Emotional Development: 2 Year Olds Page Content Article Body It’s so ... to follow the ups and downs of a two-year-old. One moment he’s beaming and friendly; ...

  4. Social Development: 1 Year Olds

    MedlinePlus

    ... Stages Listen Español Text Size Email Print Share Social Development: 1 Year Olds Page Content Article Body During his second year, your toddler will develop a very specific image of his social world, friends, and acquaintances. He ...

  5. Safety of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in adolescents aged 12-15 years: Interim analysis of a large community-randomized controlled trial.

    PubMed

    Lehtinen, Matti; Eriksson, Tiina; Apter, Dan; Hokkanen, Mari; Natunen, Kari; Paavonen, Jorma; Pukkala, Eero; Angelo, Maria-Genalin; Zima, Julia; David, Marie-Pierre; Datta, Sanjoy; Bi, Dan; Struyf, Frank; Dubin, Gary

    2016-12-01

    This community-randomized controlled trial was initiated to assess the overall and herd effects of 2 different human papillomavirus (HPV) immunization strategies in over 80,000 girls and boys aged 12-15 y in 33 communities in Finland (ClinicalTrials.gov NCT00534638). Overall, 14,838 adolescents received HPV-16/18 vaccine (2,440 boys and 12,398 girls) and 17,338 received hepatitis-B virus (HBV) vaccine (9,221 boys and 8,117 girls). In an interim analysis, vaccine safety was assessed by active monitoring and surveillance via health registry linkage. Active monitoring showed that the HPV-16/18 vaccine has acceptable safety and reactogenicity in boys. In all study participants, the observed incidences (per 100,000 person-years) of serious adverse events (SAEs) possibly related to vaccination were 54.3 (95% Confidence Interval [CI]: 34.0-82.1) in the HPV-16/18 group and 64.0 (95% CI: 43.2-91.3) in the HBV group. During the follow-up period for this interim analysis, the most common new-onset autoimmune diseases (NOADs; with incidence rate ≥15 per 100,000) in any group based on hospital discharge registry (HILMO) download were ulcerative colitis, juvenile arthritis, celiac disease, insulin-dependent diabetes mellitus (IDDM) and Crohn's disease. No increased NOAD incidences were observed in HPV-16/18 vaccine recipients compared to HBV vaccine recipients. In both the SAE possibly related- and HILMO-analyses, a lower incidence of IDDM was observed in HPV-16/18 vaccinees compared to HBV vaccinees (relative risks, 0.26 [95% CI: 0.03-1.24] and 0.16 [95% CI: 0.03-0.55], respectively).

  6. Safety of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in adolescents aged 12–15 years: Interim analysis of a large community-randomized controlled trial

    PubMed Central

    Lehtinen, Matti; Eriksson, Tiina; Apter, Dan; Hokkanen, Mari; Natunen, Kari; Paavonen, Jorma; Pukkala, Eero; Angelo, Maria-Genalin; Zima, Julia; David, Marie-Pierre; Datta, Sanjoy; Bi, Dan; Struyf, Frank; Dubin, Gary

    2016-01-01

    ABSTRACT This community-randomized controlled trial was initiated to assess the overall and herd effects of 2 different human papillomavirus (HPV) immunization strategies in over 80,000 girls and boys aged 12–15 y in 33 communities in Finland (ClinicalTrials.gov NCT00534638). Overall, 14,838 adolescents received HPV-16/18 vaccine (2,440 boys and 12,398 girls) and 17,338 received hepatitis-B virus (HBV) vaccine (9,221 boys and 8,117 girls). In an interim analysis, vaccine safety was assessed by active monitoring and surveillance via health registry linkage. Active monitoring showed that the HPV-16/18 vaccine has acceptable safety and reactogenicity in boys. In all study participants, the observed incidences (per 100,000 person-years) of serious adverse events (SAEs) possibly related to vaccination were 54.3 (95% Confidence Interval [CI]: 34.0–82.1) in the HPV-16/18 group and 64.0 (95% CI: 43.2–91.3) in the HBV group. During the follow-up period for this interim analysis, the most common new-onset autoimmune diseases (NOADs; with incidence rate ≥15 per 100,000) in any group based on hospital discharge registry (HILMO) download were ulcerative colitis, juvenile arthritis, celiac disease, insulin-dependent diabetes mellitus (IDDM) and Crohn's disease. No increased NOAD incidences were observed in HPV-16/18 vaccine recipients compared to HBV vaccine recipients. In both the SAE possibly related- and HILMO-analyses, a lower incidence of IDDM was observed in HPV-16/18 vaccinees compared to HBV vaccinees (relative risks, 0.26 [95% CI: 0.03–1.24] and 0.16 [95% CI: 0.03–0.55], respectively). PMID:27841725

  7. Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: follow-up through Month 48 in a Phase III randomized study.

    PubMed

    Einstein, Mark H; Levin, Myron J; Chatterjee, Archana; Chakhtoura, Nahida; Takacs, Peter; Catteau, Grégory; Dessy, Francis J; Moris, Philippe; Lin, Lan; Struyf, Frank; Dubin, Gary

    2014-01-01

    We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were maintained up to Month 24. Here we report follow-up data through Month 48. At Month 48, in according-to-protocol cohort for immunogenicity (seronegative and DNA-negative for HPV type analyzed at baseline), geometric mean titers of serum neutralizing antibodies were 2.0- to 5.2-fold higher (HPV-16) and 8.6- to 12.8-fold higher (HPV-18) in HPV-16/18 vaccine group than in HPV-6/11/16/18 vaccine group. The majority of women in both vaccine groups remained seropositive for HPV-16. The same trend was observed for HPV-18 in HPV-16/18 vaccine group; however, seropositivity rates in HPV-6/11/16/18 vaccine group decreased considerably, particularly in the older age groups. In the total vaccinated cohort (regardless of baseline serological and HPV-DNA status), anti-HPV-16 and -18 neutralizing antibody levels induced by HPV-16/18 vaccine were higher than those induced by HPV-6/11/16/18 vaccine. CD4+ T-cell response for HPV-16 and HPV-18 was higher in HPV-16/18 vaccine group than in HPV-6/11/16/18 vaccine group. Memory B-cell responses appeared similar between vaccine groups. Both vaccines were generally well tolerated. Overall, the higher immune response observed with the HPV-16/18 vaccine was maintained up to Month 48. A head-to-head study incorporating clinical endpoints would be required to confirm whether the observed differences in immune response between the vaccines influence the duration of protection they provided.

  8. Social Development:: 2 Year Olds

    MedlinePlus

    ... Español Text Size Email Print Share Social Development: 2 Year Olds Page Content Article Body By nature, ... probably are acting the same way. At age two, children view the world almost exclusively through their ...

  9. Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: End-of-study analysis of a Phase III randomized trial

    PubMed Central

    Einstein, Mark H; Takacs, Peter; Chatterjee, Archana; Sperling, Rhoda S; Chakhtoura, Nahida; Blatter, Mark M; Lalezari, Jacob; David, Marie-Pierre; Lin, Lan; Struyf, Frank; Dubin, Gary

    2014-01-01

    The observer-blind, randomized, age-stratified, head-to-head study (NCT00423046) comparing immunogenicity and safety of HPV-16/18 and HPV-6/11/16/18 vaccines in healthy women aged 18-45 y was completed. Five y after vaccination, in subjects from the Month 60 according-to-protocol cohort (seronegative and DNA negative for HPV type analyzed at baseline), serum neutralizing antibody (nAb) responses induced by HPV-16/18 vaccine remained 7.8-fold (18-26-y stratum), 5.6-fold (27-35-y stratum) and 2.3-fold (36-45-y stratum) higher than those induced by HPV-6/11/16/18 vaccine for HPV-16. For HPV-18, the fold differences were 12.1, 13.0 and 7.8, respectively. At Month 60, all (100%) subjects in HPV-16/18 vaccine group and the majority (95.7%-97.5%) in HPV-6/11/16/18 vaccine group were seropositive for HPV-16. For HPV-18, the majority (98.1%-100%) of subjects in HPV-16/18 vaccine group were seropositive; however, seropositivity rates in HPV-6/11/16/18 vaccine group decreased considerably (61.1%-76.9%) across the 3 age strata. In the total vaccinated cohort (received ≥ 1 dose regardless of baseline HPV serostatus and DNA status), geometric mean titers for anti-HPV-16 and anti-HPV-18 nAb were higher in HPV-16/18 vaccine group than in HPV-6/11/16/18 vaccine group. Based on the 5-y data, piece-wise and modified power-law models predicted a longer durability of nAb response for HPV-16/18 vaccine compared to HPV-6/11/16/18 vaccine. Beyond the differences apparent between the vaccines in terms of immunogenicity and modeled persistence of antibody responses, comparative studies including clinical endpoints would be needed to determine whether differences exist in duration of vaccine-induced protection. PMID:25483701

  10. Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 vaccine and HPV-6/11/16/18 vaccine: follow-up from months 12-24 in a Phase III randomized study of healthy women aged 18-45 years.

    PubMed

    Einstein, Mark H; Baron, Mira; Levin, Myron J; Chatterjee, Archana; Fox, Bradley; Scholar, Sofia; Rosen, Jeffrey; Chakhtoura, Nahida; Meric, Dorothée; Dessy, Francis J; Datta, Sanjoy K; Descamps, Dominique; Dubin, Gary

    2011-12-01

    In this observer-blind study (NCT00423046), women (N=1,106), stratified by age (18-26, 27-35, 36-45 y), were randomized (1:1) to receive the HPV-16/18 vaccine (Cervarix®, GlaxoSmithKline Biologicals, Months 0, 1, 6) or the HPV-6/11/16/18 vaccine (Gardasil® Merck & Co., Inc., Months 0, 2, 6). Month 7 results were previously reported; we now report Month 24 results. In the according-to-protocol cohort for immunogenicity (seronegative and DNA-negative at baseline for HPV type analyzed), seropositivity rates of neutralizing antibodies (nAbs) [pseudovirion-based neutralization assay] were, across all age strata, 100% (HPV-16/18 vaccine) and 97.5-100% (HPV-6/11/16/18 vaccine) for HPV-16, and 99.0-100% (HPV-16/18 vaccine) and 72.3-84.4% (HPV-6/11/16/18 vaccine) for HPV-18. Corresponding geometric mean titers (GMTs) were 2.4-5.8-fold higher for HPV-16 and 7.7-9.4-fold higher for HPV-18 with the HPV-16/18 vaccine versus the HPV-6/11/16/18 vaccine; HPV-16 and HPV-18 GMTs were significantly higher with the HPV-16/18 vaccine than the HPV-6/11/16/18 vaccine (p< 0.0001) in the total vaccinated cohort (received ≥1 vaccine dose, irrespective of baseline sero/DNA-status). Similar results were obtained using enzyme-linked immunosorbent assay (ELISA). Positivity rates and GMTs of antigen-specific IgG antibodies in cervicovaginal secretions (ELISA) were not significantly different between vaccines. At Month 24, CD4⁺ T-cell responses for HPV-16 and HPV-18 were higher with the HPV-16/18 vaccine; memory B-cell response was higher for HPV-18 with the HPV-16/18 vaccine and similar between vaccines for HPV-16. Both vaccines were generally well tolerated. Although an immunological correlate of protection has not been defined, differences in the magnitude of immune response between vaccines may represent determinants of duration of protection.

  11. Comparison of long-term immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: end-of-study analysis of a Phase III randomized trial.

    PubMed

    Einstein, Mark H; Takacs, Peter; Chatterjee, Archana; Sperling, Rhoda S; Chakhtoura, Nahida; Blatter, Mark M; Lalezari, Jacob; David, Marie-Pierre; Lin, Lan; Struyf, Frank; Dubin, Gary

    2014-01-01

    The observer-blind, randomized, age-stratified, head-to-head study (NCT00423046) comparing immunogenicity and safety of HPV-16/18 and HPV-6/11/16/18 vaccines in healthy women aged 18-45 y was completed. Five y after vaccination, in subjects from the Month 60 according-to-protocol cohort (seronegative and DNA negative for HPV type analyzed at baseline), serum neutralizing antibody (nAb) responses induced by HPV-16/18 vaccine remained 7.8-fold (18-26-y stratum), 5.6-fold (27-35-y stratum) and 2.3-fold (36-45-y stratum) higher than those induced by HPV-6/11/16/18 vaccine for HPV-16. For HPV-18, the fold differences were 12.1, 13.0 and 7.8, respectively. At Month 60, all (100%) subjects in HPV-16/18 vaccine group and the majority (95.7%-97.5%) in HPV-6/11/16/18 vaccine group were seropositive for HPV-16. For HPV-18, the majority (98.1%-100%) of subjects in HPV-16/18 vaccine group were seropositive; however, seropositivity rates in HPV-6/11/16/18 vaccine group decreased considerably (61.1%-76.9%) across the 3 age strata. In the total vaccinated cohort (received ≥1 dose regardless of baseline HPV serostatus and DNA status), geometric mean titers for anti-HPV-16 and anti-HPV-18 nAb were higher in HPV-16/18 vaccine group than in HPV-6/11/16/18 vaccine group. Based on the 5-y data, piece-wise and modified power-law models predicted a longer durability of nAb response for HPV-16/18 vaccine compared to HPV-6/11/16/18 vaccine. Beyond the differences apparent between the vaccines in terms of immunogenicity and modeled persistence of antibody responses, comparative studies including clinical endpoints would be needed to determine whether differences exist in duration of vaccine-induced protection.

  12. 46 CFR 58.16-18 - Installation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Installation. 58.16-18 Section 58.16-18 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-18 Installation. (a)...

  13. 46 CFR 58.16-18 - Installation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Installation. 58.16-18 Section 58.16-18 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-18 Installation. (a)...

  14. 46 CFR 58.16-18 - Installation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Installation. 58.16-18 Section 58.16-18 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-18 Installation. (a)...

  15. 46 CFR 58.16-18 - Installation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Installation. 58.16-18 Section 58.16-18 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-18 Installation. (a)...

  16. 46 CFR 58.16-18 - Installation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Installation. 58.16-18 Section 58.16-18 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Liquefied Petroleum Gases for Cooking and Heating § 58.16-18 Installation. (a)...

  17. Language Development: 1 Year Olds

    MedlinePlus

    ... Stages Listen Español Text Size Email Print Share Language Development: 1 Year Olds Page Content Article Body ... assured, it’s not your imagination. He’s developing his language and comprehension skills right on schedule. This giant ...

  18. Comparison of the immunogenicity of the human papillomavirus (HPV)-16/18 vaccine and the HPV-6/11/16/18 vaccine for oncogenic non-vaccine types HPV-31 and HPV-45 in healthy women aged 18-45 years.

    PubMed

    Einstein, Mark H; Baron, Mira; Levin, Myron J; Chatterjee, Archana; Fox, Bradley; Scholar, Sofia; Rosen, Jeffrey; Chakhtoura, Nahida; Lebacq, Marie; van der Most, Robbert; Moris, Philippe; Giannini, Sandra L; Schuind, Anne; Datta, Sanjoy K; Descamps, Dominique

    2011-12-01

    Protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (HPV) vaccines may provide a significant medical benefit. Available clinical efficacy data suggest the two licensed vaccines (HPV-16/18 vaccine, GlaxoSmithKline Biologicals (GSK), and HPV-6/11/16/18 vaccine, Merck & Co., Inc.) differ in terms of protection against oncogenic non-vaccine HPV types -31/45. The immune responses induced by the two vaccines against these two non-vaccine HPV types (cross-reactivity) was compared in an observer-blind study up to Month 24 (18 mo post-vaccination), in women HPV DNA-negative and seronegative prior to vaccination for the HPV type analyzed (HPV-010 [NCT00423046]). Geometric mean antibody titers (GMTs) measured by pseudovirion-based neutralization assay (PBNA) and enzyme-linked immunosorbent assay (ELISA) were similar between vaccines for HPV-31/45. Seropositivity rates for HPV-31 were also similar between vaccines; however, there was a trend for higher seropositivity with the HPV-16/18 vaccine (13.0-16.7%) versus the HPV-6/11/16/18 vaccine (0.0-5.0%) for HPV-45 with PBNA, but not ELISA. HPV-31/45 cross-reactive memory B-cell responses were comparable between vaccines. Circulating antigen-specific CD4+ T-cell frequencies were higher for the HPV-16/18 vaccine than the HPV-6/11/16/18 vaccine (HPV-31 [geometric mean ratio [GMR] =2.0; p=0.0002] and HPV-45 [GMR=2.6; p=0.0092]), as were the proportion of T-cell responders (HPV-31, p=0.0009; HPV-45, p=0.0793). In conclusion, immune response to oncogenic non-vaccine HPV types -31/45 was generally similar for both vaccines with the exception of T-cell response which was higher with the HPV-16/18 vaccine. Considering the differences in cross-protective efficacy between the two vaccines, the results might provide insights into the underlying mechanism(s) of protection.

  19. Sustained immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine administered as a two-dose schedule in adolescent girls: Five-year clinical data and modeling predictions from a randomized study

    PubMed Central

    Romanowski, Barbara; Schwarz, Tino F; Ferguson, Linda; Peters, Klaus; Dionne, Marc; Behre, Ulrich; Schulze, Karin; Hillemanns, Peter; Suryakiran, Pemmaraju; Thomas, Florence; Struyf, Frank

    2016-01-01

    In this randomized, partially-blind study (clinicaltrials.gov; NCT00541970), the licensed formulation of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine (20 μg each of HPV-16/18 antigens) was found highly immunogenic up to 4 y after first vaccination, whether administered as a 2-dose (2D) schedule in girls 9–14 y or 3-dose (3D) schedule in women 15–25 y. This end-of-study analysis extends immunogenicity and safety data until Month (M) 60, and presents antibody persistence predictions estimated by piecewise and modified power law models. Healthy females (age stratified: 9–14, 15–19, 20–25 y) were randomized to receive 2D at M0,6 (N = 240 ) or 3D at M0,1,6 (N = 239). Here, results are reported for girls 9–14 y (2D) and women 15–25 y (3D). Seropositivity rates, geometric mean titers (by enzyme-linked immunosorbent assay) and geometric mean titer ratios (GMRs; 3D/2D; post-hoc exploratory analysis) were calculated. All subjects seronegative pre-vaccination in the according-to-protocol immunogenicity cohort were seropositive for anti-HPV-16 and −18 at M60. Antibody responses elicited by the 2D and 3D schedules were comparable at M60, with GMRs close to 1 (anti-HPV-16: 1.13 [95% confidence interval: 0.82–1.54]; anti-HPV-18: 1.06 [0.74–1.51]). Statistical modeling predicted that in 95% of subjects, antibodies induced by 2D and 3D schedules could persist above natural infection levels for ≥ 21 y post-vaccination. The vaccine had a clinically acceptable safety profile in both groups. In conclusion, a 2D M0,6 schedule of the HPV-16/18 AS04-adjuvanted vaccine was immunogenic for up to 5 y in 9–14 y-old girls. Statistical modeling predicted that 2D-induced antibodies could persist for longer than 20 y. PMID:26176261

  20. 45 CFR 16.18 - Mediation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Mediation. 16.18 Section 16.18 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURES OF THE DEPARTMENTAL GRANT APPEALS... mediation skills to aid in resolving the dispute. Mediation services will only be offered at the request,...

  1. Cognitive Development: Two-Year-Old

    MedlinePlus

    ... Español Text Size Email Print Share Cognitive Development: Two-Year-Old Page Content Article Body Think back ... touching, looking, manipulating, and listening. Now, as a two-year-old, the learning process has become more ...

  2. Persistence of immune responses to the HPV-16/18 AS04-adjuvanted vaccine in women aged 15–55 years and first-time modelling of antibody responses in mature women: results from an open-label 6–year follow-up study

    PubMed Central

    Schwarz, T; Spaczynski, M; Kaufmann, A; Wysocki, J; Gałaj, A; Schulze, K; Suryakiran, P; Thomas, F; Descamps, D

    2015-01-01

    Objective Evaluation of the long-term HPV-16/18 AS04-adjuvanted vaccine immunogenicity persistence in women. Design Multicentre, open-label, long-term follow-up (NCT00947115) of a primary phase–III study (NCT00196937). Setting Six centres in Germany and Poland. Population 488 healthy women (aged 15–55 years, age-stratified into groups: 15–25, 26–45, and 46–55 years) who received three vaccine doses in the primary study. Methods Immune responses were evaluated in serum and cervicovaginal secretion (CVS) samples 6 years after dose 1. Anti-HPV-16/18 geometric mean titres (GMTs) were measured by enzyme-linked immunosorbent assay (ELISA), and were used to fit the modified power-law and piecewise models, predicting long-term immunogenicity. Serious adverse events (SAEs) were recorded. Main outcome measures Anti-HPV-16/18 seropositivity rates and GMTs 6 years after dose 1. Results At 6 years after dose 1, all women were seropositive for anti-HPV–16 and ≥97% were seropositive for anti-HPV–18 antibodies. GMTs ranged from 277.7 to 1344.6 EU/ml, and from 97.6 to 438.2 EU/ml, for anti-HPV–16 and anti-HPV–18, respectively. In all age groups, GMTs were higher (anti-HPV–16, 9.3–45.1-fold; anti-HPV–18, 4.3–19.4-fold) than levels associated with natural infection (29.8 EU/ml). A strong correlation between serum and CVS anti-HPV-16/18 levels was observed, with correlation coefficients of 0.81–0.96 (anti-HPV–16) and 0.69–0.84 (anti-HPV–18). Exploratory modelling based on the 6–year data predicted vaccine-induced anti-HPV-16/18 levels above natural infection levels for at least 20 years, except for anti-HPV–18 in the older age group (piecewise model). One vaccine-related and two fatal SAEs were reported. Conclusions At 6 years after vaccination, immune responses induced by the HPV-16/18 AS04-adjuvanted vaccine were sustained in all age groups. PMID:25208608

  3. Two-Years-Old Play and Learning.

    ERIC Educational Resources Information Center

    Adcock, Don; Segal, Marilyn

    This guide for parents discusses social competence in 2-year-old children, drawing upon anecdotal data to provide a sampling of 2-year-old children's social behavior and their parents' child rearing techniques. The data were collected from questionnaires, telephone interviews, and home visits in a 12-month study of the interactions of 86…

  4. Two-Years-Old Social Competence.

    ERIC Educational Resources Information Center

    Adcock, Don; Segal, Marilyn

    This guide for parents discusses social competence in 2-year-old children, drawing upon anecdotal data to provide a sampling of 2-year-old children's social behavior and their parents' child rearing techniques. The data were collected from questionnaires, telephone interviews, and home visits in a 12-month study of the interactions of 86…

  5. How Grammatical Are 3-Year-Olds?

    ERIC Educational Resources Information Center

    Eisenberg, Sarita L.; Guo, Ling-Yu; Germezia, Mor

    2012-01-01

    Purpose: This study investigated the level of grammatical accuracy in typically developing 3-year-olds and the types of errors they produce. Method: Twenty-two 3-year-olds participated in a picture description task. The percentage of grammatical utterances was computed and error types were analyzed. Results: The mean level of grammatical accuracy…

  6. [13-Year old boy with abdominal pain].

    PubMed

    Thomassen, Irene; Klinkhamer, Paul J J M; van de Poll, Marcel C G

    2012-01-01

    A 13-year old boy presents with pain in the lower right abdomen, showing clinical signs of appendicitis. During McBurney' incision an appendix sana was seen. Histologic examination showed penetrating enterobiasis. This was treated with mebendazol.

  7. [Schooling for Four Year Olds in California.

    ERIC Educational Resources Information Center

    Olenick, Michael

    The California State Department of Education provides part-day comprehensive development programs for 3- to 5-year-olds from low income families. The programs include educational development, health services, social services, nutrition services, parent education and participation, evaluation, and staff development. The state requires that all…

  8. Thirteen for Thirteen-Year-Olds

    ERIC Educational Resources Information Center

    Instructor, 2011

    2011-01-01

    What does it take to reach a middle school reader? Literacy expert Laura Robb recently shared her top strategies in a webcast for Scholastic fans. This article presents Robb's 13 strategies for thirteen-year-olds. These are: (1) Respect students' search for self; (2) Embrace blogging; (3) Send texts in class; (4) Take words apart; (5) Build…

  9. Efficacy of a bivalent HPV 16/18 vaccine against anal HPV16/18 infection among young women: a nested analysis within the Costa Rica Vaccine Trial

    PubMed Central

    Kreimer, Aimée R.; Gonzalèz, Paula; Katki, Hormuzd A.; Porras, Carolina; Schiffman, Mark; Rodriguez, Ana Cecilia; Solomon, Diane; Jimenez, Silvia; Schiller, John T.; Lowy, Douglas R.; van Doorn, Leen-Jan; Struijk, Linda; Quint, Wim; Chen, Sabrina; Wacholder, Sholom; Hildesheim, Allan; Herrero, Rolando

    2011-01-01

    Background Anal cancer remains rare (incidence of ∼1.5 per 100,000 women annually) but rates are increasing in many countries. Human papillomavirus-16 (HPV16) infection causes most cases. We evaluated vaccine efficacy (VE) of an ASO4-adjuvanted HPV16/18 vaccine against anal HPV16/18 infection. Methods In a randomized double-blind controlled trial designed to evaluate VE against persistent cervical HPV16/18 infections and associated precancerous lesions in Costa Rica, 4210 healthy women underwent anal specimen collection (4224 of 5968= 70.8% of eligible women) at the final blinded study visit 4 years after vaccination to evaluate anal HPV16/18 VE. Cervical HPV16/18 VE among the same women at the same visit was calculated as a comparator. For this ancillary work, analyses were conducted in a restricted cohort of women both cervical HPV16/18 DNA negative and HPV 16/18 seronegative prior at enrollment (N=1989), and in the full cohort (all women with an anal specimen). Findings In the restricted cohort, VE against prevalent HPV16/18 anal infection measured one-time, four-years post-vaccination was 83.6% (95%CI 66.7% to 92.8%), which was comparable to cervical HPV16/18 VE (87.9%, 95%CI 77.4% to 94.0%). In the full cohort, HPV16/18 VE was statistically lower at the anus (62.0%, 95%CI 47.1% to 73.1%) compared to the cervix (76.4%, 95%CI 67.0% to 83.5%) (p for anatomic-site interaction =0.03). Significant and comparable VE estimates against a composite endpoint of HPV31/33/45 (i.e.: cross-protection) was observed at the anus and cervix. Interpretation The ASO4-adjuvanted vaccine affords strong protection against anal HPV, particularly among women more likely to be HPV naïve at vaccination. Funding. The Costa Rica HPV Vaccine Trial is sponsored and funded by the NCI (contract N01-CP-11005), with funding support from the National Institutes of Health Office of Research on Women's Health, and conducted with support from the Ministry of Health of Costa Rica. Vaccine was

  10. Fitness and Your 4-to 5-Year Old

    MedlinePlus

    ... Old Feeding Your 1- to 2-Year-Old Fitness and Your 4- to 5-Year-Old KidsHealth > ... the risk of serious illnesses later in life. Fitness for Preschoolers Physical activity guidelines for preschoolers recommend ...

  11. Communication and Your 13-to 18-Year-Old

    MedlinePlus

    ... Old Feeding Your 1- to 2-Year-Old Communication and Your 13- to 18-Year-Old KidsHealth > ... games, and talking about current events. Vocabulary and Communication Teens essentially communicate as adults, with increasing maturity ...

  12. Fasciolopsiasis in a five year old girl.

    PubMed

    Naher, B S; Shahid, A T; Khan, K A; Nargis, S; Hoque, M M

    2013-04-01

    A 5 year old girl hailing from Keraniganj, presented with the complaints of fever, periumbilical pain and vomiting. In vomitus, Fasciolopsis buski worm in adult form was identified by naked eye examination. In stool, ova of Fasciolopsis buski were also observed under microscope. Clinically she was pale and had hepatomegaly. Microcytic hypochromic anaemia with normal liver function test was found on lab investigation. She was diagnosed as a case of Fasciolopsiasis and treated with Praziquantel and on follow up visit she was found to be free of symptom.

  13. Hepatoblastoma in an 11-year-old

    PubMed Central

    Pateva, Irina B.; Egler, Rachel A.; Stearns, Duncan S.

    2017-01-01

    Abstract Rationale: Hepatoblastoma is a rare malignancy. Approximately 100 cases are diagnosed yearly in the United States. The highest incidence occurs in infants and in children younger than 5 years. Cases involving patients older than 5 years are very rare. We describe the case of a patient who was diagnosed with hepatoblastoma at an atypical age of presentation for this type of malignancy. We also performed Ovid MEDLINE search for hepatoblastoma and epidemiology reports occurring in children between the ages of 5 and 18 years. In this article we review the epidemiology and summarize case reports published between 1997 and 2012 of patients with hepatoblastoma, who were older than 5 years. Patient concerns and diagnosis: Our patient is an 11 year old boy with stage IV hepatoblastoma with lung and omental metastases at diagnosis. Interventions: The patient received 7 cycles of chemotherapy following the treatment plan of COG protocol AHEP 0731, off study. He also had tumor resection and omentectomy and achieved complete remission. Outcomes: He later had disease recurrence and after undergoing treatment with different modalities, ultimately died of his disease. Review of SEER program data shows that the incidence of hepatoblastoma in children above the age of 5 years is too infrequent to be calculated. Literature review revealed 13 cases of patients diagnosed at age older than 5 years. Most cases were published due to unusual associations and/or complications. There are no obvious unifying characteristics for these cases, although there may be a slight male preponderance and many patients in this selected series presented with elevated Alpha-fetoprotein. Lessons: The reported case is rare, given the very low incidence of hepatoblastoma outside of infancy. A systematic review of characteristics and outcomes for patients older than 5 years who are enrolled in cooperative group hepatoblastoma trials may reveal important information about the epidemiology and tumor

  14. Multisite HPV16/18 Vaccine Efficacy Against Cervical, Anal, and Oral HPV Infection

    PubMed Central

    Kreimer, Aimée R.; Schiffman, Mark; Herrero, Rolando; Wacholder, Sholom; Rodriguez, Ana Cecilia; Lowy, Douglas R.; Porras, Carolina; Schiller, John T.; Quint, Wim; Jimenez, Silvia; Safaeian, Mahboobeh; Struijk, Linda; Schussler, John; Hildesheim, Allan; Gonzalez, Paula

    2016-01-01

    Background: Previous Costa Rica Vaccine Trial (CVT) reports separately demonstrated vaccine efficacy against HPV16 and HPV18 (HPV16/18) infections at the cervical, anal, and oral regions; however, the combined overall multisite efficacy (protection at all three sites) and vaccine efficacy among women infected with HPV16 or HPV18 prior to vaccination are less known. Methods: Women age 18 to 25 years from the CVT were randomly assigned to the HPV16/18 vaccine (Cervarix) or a hepatitis A vaccine. Cervical, oral, and anal specimens were collected at the four-year follow-up visit from 4186 women. Multisite and single-site vaccine efficacies (VEs) and 95% confidence intervals (CIs) were computed for one-time detection of point prevalent HPV16/18 in the cervical, anal, and oral regions four years after vaccination. All statistical tests were two-sided. Results: The multisite woman-level vaccine efficacy was highest among “naïve” women (HPV16/18 seronegative and cervical HPV high-risk DNA negative at vaccination) (vaccine efficacy = 83.5%, 95% CI = 72.1% to 90.8%). Multisite woman-level vaccine efficacy was also demonstrated among women with evidence of a pre-enrollment HPV16 or HPV18 infection (seropositive for HPV16 and/or HPV18 but cervical HPV16/18 DNA negative at vaccination) (vaccine efficacy = 57.8%, 95% CI = 34.4% to 73.4%), but not in those with cervical HPV16 and/or HPV18 DNA at vaccination (anal/oral HPV16/18 VE = 25.3%, 95% CI = -40.4% to 61.1%). Concordant HPV16/18 infections at two or three sites were also less common in HPV16/18-infected women in the HPV vaccine vs control arm (7.4% vs 30.4%, P < .001). Conclusions: This study found high multisite vaccine efficacy among “naïve” women and also suggests the vaccine may provide protection against HPV16/18 infections at one or more anatomic sites among some women infected with these types prior to HPV16/18 vaccination. PMID:26467666

  15. 29. August, 1970 WEST ELEVATIONS OF 14, 16, 18, 20 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. August, 1970 WEST ELEVATIONS OF 14, 16, 18, 20 UNION STREET (NOT IN STUDY AREA) - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  16. Growth and Your 2- to 3-Year-Old

    MedlinePlus

    ... 1- to 2-Year-Old Growth and Your 2- to 3-Year-Old KidsHealth > For Parents > Growth and Your 2- to 3-Year-Old Print A A A ... 4 pounds (1.8 kilograms) and grow about 2 to 3 inches (5 to 8 centimeters). They' ...

  17. Feeding Your 1- to 2-Year-Old

    MedlinePlus

    ... to 2-Year-Old Feeding Your 1- to 2-Year-Old KidsHealth > For Parents > Feeding Your 1- to 2-Year-Old Print A A A What's in ... español Alimentar a su hijo de 1 a 2 años de edad Toddlers this age are moving ...

  18. Growth and Your 1- to 2-Year-Old

    MedlinePlus

    ... 2-Year-Old Growth and Your 1- to 2-Year-Old KidsHealth > For Parents > Growth and Your 1- to 2-Year-Old Print A A A You're ... down. Your toddler may gain about 5 pounds (2.27 kg) and grow about 4 or 5 ...

  19. Fitness and Your 2- to 3-Year-Old

    MedlinePlus

    ... 1- to 2-Year-Old Fitness and Your 2- to 3-Year-Old KidsHealth > For Parents > Fitness and Your 2- to 3-Year-Old A A A Kids ... skills are appropriate for this age. By age 2, toddlers should be able to walk and run ...

  20. Medical Care and Your 1- to 2-Year-Old

    MedlinePlus

    ... Year-Old Medical Care and Your 1- to 2-Year-Old KidsHealth > For Parents > Medical Care and Your 1- to 2-Year-Old A A A The toddler months ... Following simple instructions? Saying a few words? Combining two words by age 2? The doctor may ask ...

  1. Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 vaccine and HPV-6/11/16/18 vaccine

    PubMed Central

    Baron, Mira; Levin, Myron J; Chatterjee, Archana; Fox, Bradley; Scholar, Sofia; Rosen, Jeffrey; Chakhtoura, Nahida; Meric, Dorothée; Dessy, Francis J; Datta, Sanjoy K; Descamps, Dominique; Dubin, Gary

    2011-01-01

    In this observer-blind study (NCT00423046), women (N = 1,106), stratified by age (18–26, 27–35, 36–45 y), were randomized (1:1) to receive the HPV-16/18 vaccine (Cervarix®, GlaxoSmithKline Biologicals, Months 0, 1, 6) or the HPV-6/11/16/18 vaccine (Gardasil® Merck and Co., Inc., Months 0, 2, 6). Month 7 results were previously reported; we now report Month 24 results. In the according-to-protocol cohort for immunogenicity (seronegative and DNA-negative at baseline for HPV type analyzed), seropositivity rates of neutralizing antibodies (nAbs) [pseudovirion-based neutralization assay] were, across all age strata, 100% (HPV-16/18 vaccine) and 97.5–100% (HPV-6/11/16/18 vaccine) for HPV-16, and 99.0–100% (HPV-16/18 vaccine) and 72.3–84.4% (HPV-6/11/16/18 vaccine) for HPV-18. Corresponding geometric mean titers (GMTs) were 2.4–5.8-fold higher for HPV-16 and 7.7–9.4-fold higher for HPV-18 with the HPV-16/18 vaccine vs. the HPV-6/11/16/18 vaccine; HPV-16 and HPV-18 GMTs were significantly higher with the HPV-16/18 vaccine than the HPV-6/11/16/18 vaccine (p < 0.0001) in the total vaccinated cohort (received ≥1 vaccine dose, irrespective of baseline sero/DNA-status). Similar results were obtained using enzyme-linked immunosorbent assay (ELISA ). Positivity rates and GMTs of antigen-specific IgG antibodies in cervicovaginal secretions (ELISA) were not significantly different between vaccines. At Month 24, CD4+ T-cell responses for HPV-16 and HPV-18 were higher with the HPV-16/18 vaccine; memory B-cell response was higher for HPV-18 with the HPV-16/18 vaccine and similar between vaccines for HPV-16. Both vaccines were generally well tolerated. Although an immunological correlate of protection has not been defined, differences in the magnitude of immune response between vaccines may represent determinants of duration of protection. PMID:22048173

  2. 28. Graffiti in north cells: '20 years old 4315 CD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Graffiti in north cells: '20 years old 4315 C-D Mamoru Yoshimoto 5/24/45 180 days Kumamoto'; '18 ' ' years old 1406-A Haruo Yokoi 6/17/45 270 days Nagoya'; '31 ' ' years old 5604-B Masaki Nishii 5/24/45 180 days Kumamoto'; '19 ' ' years old 1806-B Masaharu Yoshida 5/24/45 180 days Hiroshima'; 135mm lens with electronic flash illumination. - Tule Lake Project Jail, Post Mile 44.85, State Route 139, Newell, Modoc County, CA

  3. Mathematical Modelling with 9-Year-Olds

    ERIC Educational Resources Information Center

    English, Lyn D.; Watters, James J.

    2005-01-01

    This paper reports on the mathematical modelling of four classes of 4th-grade children as they worked on a modelling problem involving the selection of an Australian swimming team for the 2004 Olympics. The problem was implemented during the second year of the children's participation in a 3-year longitudinal program of modelling experiences…

  4. An 18-year-old man with recurrent pneumothorax since he was 10-year-old.

    PubMed

    Demir, Meral; Çobanoğlu, Nazan

    2016-12-01

    An 18-year-old male patient was referred to the department of pediatric pulmonology with a history of recurrent pneumothorax. Initial pneumothorax occurred at the age of 10. Following diagnosis of congenital lobar emphysema, he had five episodes of pneumothorax and subsequently underwent right-lower lobe anterobasal segmentectomy. Based on thoracic computed tomography (CT) and clinical manifestation, Birt-Hogg-Dube (BHD) syndrome was suspected and confirmed following genetic testing. BHD syndrome is a rare tumor predisposition syndrome first described in 1977. The syndrome is characterized by skin fibrofolliculomas, lung cysts, recurrent spontaneous pneumothorax, and renal cell cancer. The underlying cause is a germline mutation in the folliculin (FLCN) gene located on chromosome 17p11.2. Clinical manifestation usually appears after the age of 20 years. In this case, we report a case of BHD with episodes of recurrent pneumothorax, the first of which occurred at the age of 10 years. Pulmonologists should be aware of this syndrome in patients with a personal and family history of pneumothoraces and CT findings of multiple pulmonary cysts as additional evaluation and testing may be warranted. Pediatr Pulmonol. 2016;51:E41-E43. © 2016 Wiley Periodicals, Inc.

  5. Temporal Generalization in 3- to 8-Year-Old Children.

    ERIC Educational Resources Information Center

    Droit-Volet, Sylvie; Clement, Angelique; Wearden, John

    2001-01-01

    Tested 3-, 5-, and 8-year-olds on temporal generalization with visual stimuli. Found increasing sharpness of generalization gradient with increasing age, and change from symmetrical to adult-like asymmetrical generalization gradients among 8-year-olds. Theoretical models attributed changes to increasing precision of the reference memory with…

  6. Motor Proficiency Predicts Cognitive Ability in Four-Year-Olds

    ERIC Educational Resources Information Center

    Hernandez, Amanda Martinez; Caçola, Priscila

    2015-01-01

    Research has shown links between motor proficiency and cognition in school-age children, however, few have explored earlier ages. We aimed to determine the association between motor proficiency and cognitive ability in four-year-olds. Motor and cognitive skills were examined in 32 (15 males, 17 females) four-year-olds (±5.59 months) using the…

  7. Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine

    PubMed Central

    Naud, Paulo S; Roteli-Martins, Cecilia M; De Carvalho, Newton S; Teixeira, Julio C; de Borba, Paola C; Sanchez, Nervo; Zahaf, Toufik; Catteau, Gregory; Geeraerts, Brecht; Descamps, Dominique

    2014-01-01

    HPV-023 (NCT00518336; ClinicalTrial.gov) is a long-term follow-up of an initial double-blind, randomized (1:1), placebo-controlled study (HPV-001, NCT00689741) evaluating the efficacy against human papillomavirus (HPV)-16/18 infection and associated cyto-histopathological abnormalities, persistence of immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine. Among the women, aged 15–25 years, enrolled in HPV-001 and who participated in the follow-up study HPV-007 (NCT00120848), a subset of 437 women from five Brazilian centers participated in this 36-month long-term follow-up (HPV-023) for a total of 113 months (9.4 years). During HPV-023, anti-HPV-16/18 antibodies were measured annually by enzyme-linked immunosorbent assay (ELISA) and pseudovirion-based neutralisation assay (PBNA). Cervical samples were tested for HPV DNA every 6 months, and cyto-pathological examinations were performed annually. During HPV-023, no new HPV-16/18-associated infections and cyto-histopathological abnormalities occurred in the vaccine group. Vaccine efficacy (VE) against HPV-16/18 incident infection was 100% (95%CI: 66.1, 100). Over the 113 months (9.4 years), VE was 95.6% (86.2, 99.1; 3/50 cases in vaccine and placebo groups, respectively) against incident infection, 100% (84·1, 100; 0/21) against 6-month persistent infection (PI); 100% (61·4, 100; 0/10) against 12-month PI; 97·1% (82.5, 99.9; 1/30) against ≥ ASC-US; 95·0% (68.0, 99.9; 1/18) against ≥ LSIL; 100% (45.2, 100; 0/8) against CIN1+; and 100% (–128.1, 100; 0/3) against CIN2+ associated with HPV-16/18. All vaccinees remained seropositive to HPV-16/18, with antibody titers remaining several folds above natural infection levels, as measured by ELISA and PBNA. There were no safety concerns. To date, these data represent the longest follow-up reported for a licensed HPV vaccine. PMID:25424918

  8. Puzzlemaking and Part-Whole Perception of Two-Year-Old and Four-Year-Old Children

    ERIC Educational Resources Information Center

    Montford, Emily I. Purvis; Readdick, Christine A.

    2008-01-01

    The relationship between preschoolers' puzzlemaking strategies and part-whole perception was investigated in the present study. Forty-eight two year olds and 48 four year olds were randomly selected from eight licensed childcare centers. Puzzlemaking strategies (image, form, color, and trial and error) were measured by performance in the…

  9. The ADS Abstract Service: One Year Old

    NASA Astrophysics Data System (ADS)

    Grant, C. Stern; Kurtz, M. J.; Eichhorn, G.

    1994-05-01

    One year after its initial release the ADS Abstract Service has become quite widely used. More than 1000 different people use it per month, making about 20,000 queries and obtaining a couple of hundred thousand pieces of bibliographic information. In February a WWW connection was released, it has been heavily used. The collaboration with SIMBAD, released in January, allows one to make complex queries about work on particular objects. For example one may search for all papers which SIMBAD says are about M87, and which contain the words ``globular cluster'' in the abstract, thus getting the 65 papers on the M87 globular cluster system. One can also look for papers which have the words ``M87 globular clusters'' in the abstract, but are not listed in SIMBAD; this obtains another 19 papers, mostly conference procedings, about the M87 globular cluster system. The figure shows the list of non-SIMBAD papers.

  10. Lindane toxicity to one year old calves

    SciTech Connect

    Venant, A.; Borrel, S.; Mallet, J. ); Sery, C. )

    1991-05-01

    Lindane (the gamma isomer of 1,2,3,4,5,6 hexachlorocyclohexane) is still recommended and used as seed treatment and for control of pests especially against lice and ticks on sheep and cattle (but not on dairy cattle and laying hens). Unlike others organochlorine pesticides, lindane does not persist in the environment or in living animals. Multitest data have established that is not a highly toxic pesticide. About domestic animals toxicity, no exact data is available and LD50 is not exactly known. Values obtained after an accidental intoxication allow the authors to have some data on toxicity levels and on toxic origin symptoms. During the last year, one case of intoxication of calves was investigated on 30 calves (sprayed against ectoparasite with lindane) in which 5 died. Results are reported in the present work.

  11. Drug Ingestions in Children 10-14 Years Old: An Old Problem Revisited

    ERIC Educational Resources Information Center

    Pomerantz, Wendy; Gittelman, Michael; Farris, Sarah; Frey, Lauren

    2009-01-01

    To determine changes in rates of drug ingestions in 10-14 year old children in our country, a retrospective chart review of 10-14 year olds hospitalized for drug ingestion between 1993-1995 and 2000-2004 was performed. Odds ratios and Chi-square were used for analyses. From 1993-1995 there were 92.8 ingestions/100,000 children/year; from 2000-2004…

  12. Medical Care and Your 4- to 5-Year-Old

    MedlinePlus

    ... compared with other kids the same age and gender. The doctor will take a medical and family ... cooperatively with other kids understand the concept of gender identify colors Developmental milestones for 5-year-olds ...

  13. Medical Care and Your 6- to 12-Year-Old

    MedlinePlus

    ... compared with other kids the same age and gender. The doctor will take a medical and family ... Talking to Your Child About Puberty Understanding Puberty Communication and Your 6- to 12-Year-Old Contact ...

  14. The First Year Inventory: A Longitudinal Follow-Up of 12-Month-Old to 3-Year-Old Children

    ERIC Educational Resources Information Center

    Turner-Brown, Lauren M.; Baranek, Grace T.; Reznick, J Steven; Watson, Linda R.; Crais, Elizabeth R.

    2013-01-01

    The First Year Inventory is a parent-report measure designed to identify 12-month-old infants at risk for autism spectrum disorder. First Year Inventory taps behaviors that indicate risk in the developmental domains of sensory--regulatory and social--communication functioning. This longitudinal study is a follow-up of 699 children at 3 years of…

  15. True or False: Do 5-Year-Olds Understand Belief?

    ERIC Educational Resources Information Center

    Fabricius, William V.; Boyer, Ty W.; Weimer, Amy A.; Carroll, Kathleen

    2010-01-01

    In 3 studies (N = 188) we tested the hypothesis that children use a perceptual access approach to reason about mental states before they understand beliefs. The perceptual access hypothesis predicts a U-shaped developmental pattern of performance in true belief tasks, in which 3-year-olds who reason about reality should succeed, 4- to 5-year-olds…

  16. Can bilingual two-year-olds code-switch?

    PubMed

    Lanza, E

    1992-10-01

    Sociolinguists have investigated language mixing as code-switching in the speech of bilingual children three years old and older. Language mixing by bilingual two-year-olds, however, has generally been interpreted in the child language literature as a sign of the child's lack of language differentiation. The present study applies perspectives from sociolinguistics to investigate the language mixing of a bilingual two-year-old acquiring Norwegian and English simultaneously in Norway. Monthly recordings of the child's spontaneous speech in interactions with her parents were made from the age of 2;0 to 2;7. An investigation into the formal aspects of the child's mixing and the context of the mixing reveals that she does differentiate her language use in contextually sensitive ways, hence that she can code-switch. This investigation stresses the need to examine more carefully the roles of dominance and context in the language mixing of young bilingual children.

  17. [Sexuality in children 9-14 years old].

    PubMed

    Ballester Arnal, Rafael; Gil Llario, María Dolores

    2006-02-01

    The aim of this study was to analyze sexual behaviors and attitudes of children 9-14 years old in Spain. In this article we present data from 470 children of which 52% are boys and 48% girls. In order to evaluate the sample, Information, Attitudes and Behaviors related to Health Questionnaire (CIACS-II) was used. Results evidence that boys 9 years old already show behaviors that evidence their interest towards sexuality. 8% have sometimes masturbated and 9% have used pornography for becoming excited. 14% of children 11-12 years old have already had sexual relations and 38% state to have sexual fantasies. Girls start to masturbate and to have sexual relations later than boys and show a prevalence of sexual fantasies and use of pornography very lower. It is necessary sexual education programs to be implanted since early ages in schools.

  18. Gender, Popularity and Notions of In/Authenticity amongst 12-Year-Old to 13-Year-Old School Girls

    ERIC Educational Resources Information Center

    Read, Barbara; Francis, Becky; Skelton, Christine

    2011-01-01

    This paper draws on data from a research project investigating gendered identities and interactions of high-achieving students in Year Eight in England (12-13 years old), particularly in relation to students' "popularity" amongst their peers. As part of this study 71 students were interviewed from nine different schools in urban, rural…

  19. Similarity Predicts Liking in 3-Year-Old Children

    ERIC Educational Resources Information Center

    Fawcett, Christine A.; Markson, Lori

    2010-01-01

    Two studies examined the influence of similarity on 3-year-old children's initial liking of their peers. Children were presented with pairs of childlike puppets who were either similar or dissimilar to them on a specified dimension and then were asked to choose one of the puppets to play with as a measure of liking. Children selected the puppet…

  20. Five-Year-Olds' Fascination for Television: A Comparative Study.

    ERIC Educational Resources Information Center

    Hake, Karin

    2001-01-01

    Compared 5-year-olds' understanding of and fascination with a public service and a commercial television program; also compared parents' and children's perspectives. Found that children were particularly fascinated by sequences containing conflicts and aggression. Sixteen of 20 children chose the commercial channel program. Parents showed insight…

  1. [Cystic fibrosis in a 70-year-old woman].

    PubMed

    Bruun, Lene Søndberg; Jensen, Michael Skov

    2002-05-06

    Cystic fibrosis is usually diagnosed in early childhood, and patients rarely live beyond the age of 40. We present a case of a 70-year-old woman, in whom cystic fibrosis was diagnosed with the rare mutation, R117C. Cystic fibrosis should therefore also be considered in older patients.

  2. Headshaking in a 10-year-old Thoroughbred mare

    PubMed Central

    2004-01-01

    Abstract A 10-year-old Thoroughbred mare was presented with a 2.5-week history of headshaking. Based on a thorough physical examination, blood analysis, and a fine needle aspirate of an enlarged thyroid gland, a tentative diagnosis of seasonal idiopathic headshaking was made. Treatment with cyproheptadine was attempted. PMID:15025153

  3. 2-Year-Olds' Speech Understanding in Multitalker Environments

    ERIC Educational Resources Information Center

    Newman, Rochelle S.

    2011-01-01

    Infants and toddlers are often spoken to in the presence of background sounds, including speech from other talkers. Prior work has suggested that infants 1 year of age and younger can only recognize speech when it is louder than any distracters in the environment. The present study tests 24-month-olds' ability to understand speech in a multitalker…

  4. Mathematics Skills of Nine-Year-Olds: 1978 to 2004

    ERIC Educational Resources Information Center

    Kloosterman, Peter

    2011-01-01

    Using recently released data from the Long-Term Trend Assessment of the National Assessment of Educational Progress, this study analyzed the mathematics performance of 9-year-old students between 1978 and 2004. The study goes beyond overall results by describing the assessment items and the change over time on each of those items. The data…

  5. Repetitive Behaviours in Typically Developing 2-Year-Olds

    ERIC Educational Resources Information Center

    Leekam, Susan; Tandos, Jonathan; McConachie, Helen; Meins, Elizabeth; Parkinson, Kathryn; Wright, Charlotte; Turner, Michelle; Arnott, Bronia; Vittorini, Lucia; Le Couteur, Ann

    2007-01-01

    Background: Repetitive behaviours are an essential part of the diagnosis of autism but are also commonly seen in typically developing children. The current study investigated the frequency and factor structure of repetitive behaviours in a large community sample of 2-year-olds. Methods: A new measure, the Repetitive Behaviour Questionnaire (RBQ-2)…

  6. The Perceptions of Five Years Old Group Students' about Scientists

    ERIC Educational Resources Information Center

    Zeynep Et, Sümeyra; Memis, Esra Kabatas

    2017-01-01

    The purpose of this research is to reveal the perceptions of students of five years old group about scientists. The practice was implemented with 76 students having education in five-age group continuing to various nursery schools located in the center of Kastamonu province. Before starting the practice, the teacher asked the questions of…

  7. Giant parapox infection in a two year old child.

    PubMed

    Rogers, M; Bale, P; De Silva, L M; Glasson, M J; Collins, E

    1989-01-01

    We report the case of a two year old boy who developed a large tumour on his face. The lesion resembled a pyogenic granuloma clinically and histologically. Viral studies indicated a parapox infection and a bovine source was supported on epidemiological grounds. The lesion was removed by shave excision and the area healed without significant scarring.

  8. One-Year-Olds Think Creatively, Just Like Their Parents

    ERIC Educational Resources Information Center

    Hoicka, Elena; Mowat, Rachael; Kirkwood, Joanne; Kerr, Tiffany; Carberry, Megan; Bijvoet-van den Berg, Simone

    2016-01-01

    Creativity is an essential human ability, allowing adaptation and survival. Twenty-nine 1-year-olds and their parents were tested on divergent thinking (DT), a measure of creative potential counting how many ideas one can generate. Toddlers' and parents' DT was moderately to highly correlated. Toddlers showed a wide range of DT scores, which were…

  9. Two-Year-Olds Compute Syntactic Structure On-Line

    ERIC Educational Resources Information Center

    Bernal, Savita; Dehaene-Lambertz, Ghislaine; Millotte, Severine; Christophe, Anne

    2010-01-01

    Syntax allows human beings to build an infinite number of new sentences from a finite stock of words. Because toddlers typically utter only one or two words at a time, they have been thought to have no syntax. Using event-related potentials (ERPs), we demonstrated that 2-year-olds do compute syntactic structure when listening to spoken sentences.…

  10. Enterobius vermicularis in a 14-year-old girl's eye.

    PubMed

    Babady, N Esther; Awender, Erich; Geller, Robert; Miller, Terry; Scheetz, Gayle; Arguello, Heather; Weisenberg, Scott A; Pritt, Bobbi

    2011-12-01

    We report an unusual case of extraintestinal infection with adult Enterobius vermicularis worms in the nares and ocular orbit of a 14-year-old girl in Illinois. Only one other similar case has been reported in the English-language literature.

  11. Rhinoscleroma in a 5-year-old Portuguese Child.

    PubMed

    Simão, Inês; Gaspar, Iuri; Faustino, Rosário; Brito, Maria João Rocha

    2014-07-01

    Rhinoscleroma is a chronic granulomatous infectious disease that is rare in Western Europe. We report the case of a 5-year-old Portuguese boy diagnosed with rhinoscleroma in the context of recurrent epistaxis. He had a 6-month course of antibiotic (amoxicillin plus clavulanate) therapy with full recovery.

  12. Triadic Interaction among Newly Acquainted 2-Year-Olds

    ERIC Educational Resources Information Center

    Ishikawa, Fumiko; Hay, Dale F.

    2006-01-01

    Are children as young as 2 years old able to interact in groups of three? The study applied the family triad model first introduced by Parke, Power, and Gottman (1979) to the case of peer interaction. In Experiment 1, the model was refined for use in studies of peer interaction and applied to an existing dataset of 16 triads of newly acquainted…

  13. A 4-year-old Nigerian boy with cerebral palsy?

    PubMed

    Bodensteiner, John B

    2014-06-01

    A four year old with a diagnosis of congenital infection leading to cerebral palsy is presented. The patient instead has a condition called Leukoencephalopathy with bilateral temporal lobe cysts which can be differentiated from congenital CMV by the clinical and MRI findings.

  14. Sebaceous adenitis in a 7-year-old Arabian gelding

    PubMed Central

    2006-01-01

    Abstract A 7-year-old Arabian gelding was presented with a 9-month history of progressive patches of nonpruritic scaling, crusting, alopecia, and leukoderma of the periocular areas and muzzle, becoming generalized over time. Sebaceous adenitis was diagnosed on histopathologic examination. Lesions resolved without treatment, coinciding with regression of a sarcoid on the neck. PMID:16808233

  15. Assessing Two-Year-Olds' Knowledge of Number Agreement Morphology

    ERIC Educational Resources Information Center

    Blossom, Megan

    2013-01-01

    Previous research in the area of children's knowledge of number agreement morphology has yielded mixed results. Some researchers have found evidence for sensitivity to agreement morphology at as early as 16 months, while others report that children do not comprehend number agreement morphology until as late as five or six years old. Studies of…

  16. [Acute myocardial infarction in a 5-year-old boy].

    PubMed

    Romero Ibarra, C; Bueno Campaña, M; Barriuso Lapresa, L M; de Miguel Medina, C; Maraví Poma, E

    1996-11-01

    We present the case of a child five and half years-old that died suddenly due to an acute myocardial infarction. The anatomopathological study showed a total obstruction of the left coronary ostium by mixoide dysplasia of the aortic valve. We revise the literature and briefly expose the more frequent causes of infarction in infancy.

  17. Intensity Accents in French 2 Year Olds' Speech.

    ERIC Educational Resources Information Center

    Allen, George D.

    The acoustic features and functions of accentuation in French are discussed, and features of accentuation in the speech of French 2-year-olds are explored. The four major acoustic features used to signal accentual distinctions are fundamental frequency of voicing, duration of segments and syllables, intensity of segments and syllables, and…

  18. Heart Health...Your Choice. 11-14 Year Olds.

    ERIC Educational Resources Information Center

    National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD.

    The purpose of this illustrated booklet is to teach 11-14 year old students that all healthy Americans, 2 years of age or older, should eat in a way that is low in saturated fat and cholesterol to help reduce the risk of heart disease. The guide is designed to promote changes in eating patterns, to show children how to switch to good eating…

  19. Dietary Habits of Welsh 12-13 Year Olds

    ERIC Educational Resources Information Center

    Thomas, Non-Eleri; Cooper, Stephen-Mark; Graham, Mike; Boobier, Wyndham; Baker, Julien; Davies, Bruce

    2007-01-01

    This study examined the dietary habits of Welsh 12-13 year olds. A cohort of 84 boys and 81 girls, age 12.9 SD 0.3 years; body mass 51.3 SD 12.6kg; and stature 1.54 SD 0.08m, completed a food frequency questionnaire and seven-day food diary. Mean daily kilocalories (kcal/d), and percentages of total fat, saturated fat, carbohydrate, and protein,…

  20. Edwards syndrome in a 6-year old girl.

    PubMed

    Raczkowski, Jan W; Daniszewska, Barbara; Paradecka, Anna

    2010-01-01

    Trisomy 18 (Edwards syndrome - ES) is the second most common trisomy. It occurs in 1/3 000 to 1/8 000 births. ES is a cause of numerous developmental disorders and malformations. The median life span of children with ES is about 2 weeks and only 5%-10% will survive their first year of life. The report presents a case of a 6-year-old girl with ES.

  1. A 15 year old boy with a posterior fossa tumor.

    PubMed

    Chapman, Erin M; Ranger, Adrianna; Lee, Donald H; Hammond, Robert R

    2009-04-01

    A 15 year old male presented with hydrocephalus from a tectal mass obstructing the cerebral aqueduct and upper fourth ventricle. The solid-cystic partly enhancing mass proved to be a pigmented pleomorphic xanthoastrocytoma, the third such example reported. The lesion revealed typical features of a PXA with the unusual addition of intracytoplasmic melanin in select lesional cells. Melanin pigment production is uncommon in glial tumors and of uncertain significance. The present case is recurrence-free one year post-operatively.

  2. Magnesium metabolism in 4-year-old to 8-year-old children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Magnesium (Mg) is a key factor in bone health, but few studies have evaluated Mg intake or absorption and their relationship with bone mineral content (BMC) or bone mineral density (BMD) in children. We measured Mg intake, absorption, and urinary excretion in a group of children 4 to 8 years of age....

  3. An 81-year-old gentleman with symptomatic Bochdalek hernia

    PubMed Central

    Rajput, Mohammed Zak; Fisichella, Piero Marco

    2013-01-01

    An 81-year-old gentleman with congenital polycystic kidney disease presented to his primary care physician with dysphagia, gastroesophageal reflux refractory to medical management, and 11.25 kg weight loss in a 6 mo-period. A barium swallow misdiagnosed a paraesophageal hernia for a Bochdalek hernia. Herein, we highlight how a Bochdalek hernia may be disregarded in the differential diagnosis and how providers can resort to a more common diagnosis, a paraesophageal hernia, which is more frequently encountered in old age and whose radiologic appearance might mimic a Bochdalek hernia. PMID:23894690

  4. An 81-year-old gentleman with symptomatic Bochdalek hernia.

    PubMed

    Rajput, Mohammed Zak; Fisichella, Piero Marco

    2013-07-27

    An 81-year-old gentleman with congenital polycystic kidney disease presented to his primary care physician with dysphagia, gastroesophageal reflux refractory to medical management, and 11.25 kg weight loss in a 6 mo-period. A barium swallow misdiagnosed a paraesophageal hernia for a Bochdalek hernia. Herein, we highlight how a Bochdalek hernia may be disregarded in the differential diagnosis and how providers can resort to a more common diagnosis, a paraesophageal hernia, which is more frequently encountered in old age and whose radiologic appearance might mimic a Bochdalek hernia.

  5. Resistant retinoblastoma in a 23-year-old patient

    PubMed Central

    Yousef, Yacoub A.; Istetieh, Jihad; Nawaiseh, Ibrahim; Al-Hussaini, Maysa; Alrawashdeh, Khalil; Jaradat, Imad; Sultan, Iyad; Mehyar, Mustafa

    2014-01-01

    Retinoblastoma is a very rare disease in adults. We are reporting a rare case of resistant retinoblastoma in 23-year-old patient. A 23-year-old male patient presented with loss of vision in the right eye over one-month duration. Examination showed an epiretinal membrane in the right macula in addition to a white mass located inferiorly and associated with vitreous seeds. The diagnosis of retinoblastoma was established. In order to save the patient's life and to preserve the eye and vision, he was treated with chemotherapy, focal therapy, and radioactive Iodine125 plaque therapy. The tumor was resistant for treatment and recurred two years after plaque therapy, and enucleation showed well-differentiated retinoblastoma. Retinoblastoma may present in adults, and it was resistant to both chemotherapy and plaque radiation therapy in our case. PMID:25378879

  6. Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children

    ERIC Educational Resources Information Center

    Devine, Paula; Lloyd, Katrina

    2012-01-01

    This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

  7. Endometrial adenocarcinoma in a 13-year-old girl

    PubMed Central

    Kim, Sung Mee; Shin, So Jin; Bae, Jin Gon; Kwon, Kun Young

    2016-01-01

    Endometrial cancer is the third most common gynecologic cancer in the Korea and occurs mainly in menopausal women. Although it can develop in young premenopausal women cancer as well, an attack in the adolescent girl is very rare. A 13-year-old girl visited gynecology department with the complaint of abnormal uterine bleeding. An endometrial biopsy revealed FIGO (International Federation of Gynecology and Obstetrics) grade II endometrial adenocarcinoma. In the treatment of endometrial cancer, conservative management should be considered if the patient is nulliparous or wants the fertility preservation. Therefore, we decided to perform a hormonal therapy and a follow-up endometrial biopsy after progestin administration for eight months revealed no residual tumor. We report a case of endometrial cancer occurred in a 13-year-old girl with a brief review of the literature. PMID:27004208

  8. Mandibular Dentigerous Cyst in a 10-Year-Old Child

    PubMed Central

    Bhardwaj, Bindu; Sharma, Sunil; Agarwal, Prateek; Bhamboo, Amit; Rastogi, Komal

    2016-01-01

    Dentigerous cyst is the most common odontogenic cyst. It is characterized by a unilocular radiolucent lesion that encloses permanent tooth buds or, under certain circumstances, displaced tooth buds. Buccal bony expansion and a missing tooth is the most common clinical feature. Various treatment modalities have been mentioned in the literature for management of dentigerous cysts. This article presents a left mandibular dentigerous cyst in a 10-year-old boy. Marsupialization was the treatment of choice and a denturelike space maintainer was provided. Long-term follow-up revealed good healing of the bony lesion. How to cite this article Bhardwaj B, Sharma S, Chitlangia P, Agarwal P, Bhamboo A, Rastogi K. Mandibular Dentigerous Cyst in a 10-Year-Old Child. Int J Clin Pediatr Dent 2016;9(3): 281-284. PMID:27843264

  9. Portion size variably affects food intake of 6-year-old and 4-year-old children in Kunming, China.

    PubMed

    Smith, Lindsey; Conroy, Katharine; Wen, Hongmei; Rui, Li; Humphries, Debbie

    2013-10-01

    Age and portion size have been found to influence food intake in American children but have not been examined in an international context. This study evaluated the association between age and the effects of portion size on the food intake of kindergarteners in Kunming, China. Using a within-subjects crossover design in a classroom setting, 173 children in two age groups, mean age 4.2 years and 6.1 years, were served a predefined reference, small (-30%) and large (+30%) portion of rice, vegetables, and a protein source during lunchtime over three consecutive days. Each portion was weighed before and after the meal to determine amount of food consumed. Linear mixed modeling, controlling for repeated measures and clustering by classroom, was used to compare food intake under small and large portion size conditions to the reference portion. Children ate significantly less food when served small portions. When served a large portion, 6-year-old children increased food intake while 4-year-old children decreased food intake in comparison to the reference portion. Findings indicate that portion size affects food intake in Chinese children 4-6-years old. Older children show larger increases in food intake with increased portion size than do younger children.

  10. Interrupted aorta diagnosed in a 51-year-old woman.

    PubMed

    Stoyanov, Nik; Bullock, Andrew; Erickson, Matthew

    2014-10-01

    A 51-year-old lady presented with increasing heart failure symptoms and palpitations. She had recently been diagnosed with a congenital ventricular septal defect, bicuspid aortic valve, and Eisenmenger's syndrome. There was clinical evidence of right heart failure and differential clubbing and cyanosis affecting the feet but not hands. A cardiac magnetic resonance imaging demonstrated interruption of the aortic arch beyond the left subclavian artery, with the descending aorta perfused entirely through a large patent ductus arteriosus.

  11. Systemic cold urticaria in a five-year-old boy.

    PubMed

    Orfan, N; Marhoul, J; Lerner, C; Lawrence, I D

    1991-08-01

    A 5-year-old white boy had a history of generalized urticaria on total body exposure to a cold environment. Standard ice cube testing was negative. Plasma analysis revealed the presence of cryofibrinogen. Systemic cold challenge with serial plasma assays for complement, histamine, and prostaglandin D2 disclosed an elevation and peak of plasma histamine and prostaglandin D2 levels after the onset of generalized urticaria with no change in serum complement levels.

  12. Hirayama disease in a 17-year-old Chinese man

    PubMed Central

    Sitt, Jacqueline Ching Man; Fung, Eva Lai Wah; Yuen, Edmund Hok-Yuen; Ahuja, Anil Tejbhan

    2014-01-01

    Hirayama disease is an uncommon cervical myelopathy associated with neck flexion. It has been postulated to be related to the anterior shifting of the posterior dura of the lower cervical dural canal during neck flexion, resulting in lower cervical cord atrophy with asymmetric flattening. We report a case of Hirayama disease in a 17-year-old Chinese man and demonstrate the use of dynamic flexion magnetic resonance imaging of the cervical spine in the diagnosis of the disease. PMID:24379115

  13. A Five-Year-Old Child with Renal Hydatidosis

    PubMed Central

    Moscatelli, Guillermo; Moroni, Samanta; Freilij, Héctor; Salgueiro, Fabián; García Bournissen, Facundo; Altcheh, Jaime

    2013-01-01

    Hydatidosis is a zoonosis of worldwide distribution caused by the parasite Echinococcus granulosus. Clinical manifestations include cyst formation, most commonly in the liver (67–89%) and lungs (10–15%). Renal localizations are rare. We report a case of renal hydatidosis in a five-year-old child treated in a tertiary pediatric hospital in Argentina. After the diagnosis was made, elective surgery was performed, which led to a rapid recovery. PMID:23897992

  14. Pyomyositis in a 69-year-old tennis player.

    PubMed

    Burkhart, Bradd G; Hamson, Karl R

    2003-11-01

    Pyomyositis is an acute bacterial infection of skeletal muscle usually caused by Staphylococcus aureus. Outside of tropical areas, pyomyositis is rare, especially in an otherwise healthy individual. We present a case of a 69-year-old tennis professional who developed pyomyositis of the piriformis muscle following a tennis tournament. We discuss the literature on pyomyositis and the need for high clinical suspicion in the diagnosis of this disorder, as well as the need for early aggressive antibiotic treatment.

  15. [Dermatobia hominis infection in a 3-year-old child].

    PubMed

    Meissner, M; Kippenberger, S; Valesky, E M; Kaufmann, R

    2012-04-01

    In the context of increasing travel to the tropics, outpatient services are more frequently confronted with non-domestic diseases in Europe. A 3-year old child presented with a painful tumor of the scalp. After incision of the furuncle-like lesion, we extracted a larva of the botfly Dermatobia hominis. Botflies are mainly encountered in Central and South America; they should be considered if patients demonstrate a furuncle-like lesion and have returned from a holiday in these endemic regions.

  16. A 50-Year-Old Woman Addicted to Heroin

    PubMed Central

    O’Brien, Charles P.

    2011-01-01

    Heroin addiction is a complicated medical and psychiatric issue, with well-established as well as newer modes of treatment. The case of Ms W, a 50-year-old woman with a long history of opiate addiction who has been treated successfully with methadone for 9 years and who now would like to consider newer alternatives, illustrates the complex issues of heroin addiction. The treatment of heroin addiction as a chronic disease is reviewed, including social, medical, and cultural issues and pharmacologic treatment with methadone and the more experimental medication options of buprenorphine and naltrexone. PMID:18594026

  17. Prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology*

    PubMed Central

    Ye, Jing; Cheng, Bei; Cheng, Yi-fan; Yao, Ye-li; Xie, Xing; Lu, Wei-guo; Cheng, Xiao-dong

    2017-01-01

    Histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. In this study, we assessed the triage value of human papillomavirus (HPV) 16/18 genotyping in 273 patients with LSIL/CIN1. HPV16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. At each follow-up, women positive for cytology or high-risk HPV (hrHPV) were referred for colposcopy. Enrollment cytology, HPV16/18 genotyping, and questionnaire-obtained factors were linked to the 2-year cumulative progression rate. Univariate and multivariate analyses were performed taking into account time-to-event with Cox proportional hazard regression. The results showed that 190 cases (69.6%) regressed, 37 (13.6%) persisted, and 46 (16.8%) progressed. HPV16/18 positivity (hazard ratio (HR), 2.708; 95% confidence interval (CI), 1.432–5.121; P=0.002) is significantly associated with higher 2-year cumulative progression rate. Sub-analysis by enrollment cytology and age restricted the positive association among patients preceded by mildly abnormal cytology and aged 30 years or older. Immediate treatment is a rational recommendation for the high-risk subgroup, when good compliance is not assured. PMID:28271660

  18. Oral cleanliness of 12-13-year-old and 15-year-old school children of Sunsari District, Nepal.

    PubMed

    Yee, R; David, J; Khadka, R

    2006-09-01

    The aim of the study was to evaluate the oral cleanliness of school children in the District of Sunsari, Nepal. A multi-stage random sampling oral epidemiological survey was conducted in private and government, urban, rural town and rural village schools in 15 illakas of Sunsari District, Eastern Nepal. A total of 600, 12-13-year-old and 600 15-year-old school children were examined by trained examiners using the simplified oral hygiene index (OHI-S). The average age-group, debris and calculus index scores were combined to obtain the simplified oral hygiene index (OHI-S). The mean OHI-S scores were compared and evaluated using the parametric t-test for two independent samples. The mean OHI-S for urban 12-13-year-old school children was 0.98 compared to 1.34 for school children of rural towns and 1.44 for school children of rural villages and these differences in mean OHI-S were statistically significant (P < 0.005). In the 15-year-old age group, urban school children had a mean OHI-S score of 1.00 compared to 1.37 for rural towns and 1.43 for rural villages. The variance in the mean OHI-S scores were statistically significant (P < 0.005). The overall level of cleanliness in the school children surveyed was good. Children of urban schools had the lowest scores followed by school children from rural towns and then rural villages. When the mean OHI-S scores were compared with the DMFT scores, there was an inverse relationship between oral cleanliness and dental caries. Frequency of sugar consumption and the availability and affordability of fluoridated toothpaste may be important factors in the development of dental caries than oral cleanliness.

  19. A 62-year-old man with dyspnea

    PubMed Central

    Baqir, Misbah; Ryu, Jay H.; Sorenson, Eric J.; Olson, Eric J.

    2016-01-01

    We describe the case of a 62-year-old man who presented with shortness of breath that had progressed over several years. He had a history of a paralyzed right hemidiaphragm for at least the previous 10 years. He also reported weakness in his proximal legs and daytime sleepiness. On examination, he was found to have thoracoabdominal paradox when in supine position. Pulmonary function testing revealed severe restriction; arterial blood gas showed chronic respiratory acidosis. Electromyography showed chronic phrenic neuropathy bilaterally, with mild proximal myopathy. Serum aldolase level was mildly elevated, but serologic tests for connective tissue disorders were within reference range. After extensive clinical investigations, the patient was found to have severely reduced acid α-glucosidase. Genetic analysis confirmed the diagnosis of adult-onset Pompe disease. The patient started treatment with bilevel positive airway pressure titrated during polysomnography, and acid α-glucosidase enzyme replacement was recommended. PMID:27141434

  20. Huge Gastric Teratoma in an 8-Year Old Boy

    PubMed Central

    Ratan, Simmi K; Man, Parveen k

    2016-01-01

    Gastric teratoma is very rare tumor and usually presents in early infancy. An 8-year-old boy presented with a huge mass in abdomen extending from epigastrium to the pelvis. Ultrasound and CT scan of abdomen revealed a huge mass with solid and cystic components and internal calcifications. The preoperative diagnosis was a teratoma but not specifically gastric one. At operation, it was found to be gastric teratoma. The mass was excised completely with part of the stomach wall. The histopathology confirmed it to be mature gastric teratoma. The rarity of the teratoma with delayed presentation prompted us to report the case. PMID:27900279

  1. NASA Administrator Dan Goldin greets 100-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Among the VIPs attending the launch of STS-99 is Captain Ralph Charles (left), standing next to NASA Administrator Dan Goldin. Charles hopes to have his wish fulfilled of watching a Shuttle launch in person. The 100-year-old aviator has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles is the oldest licensed pilot in the United States, and is still flying.

  2. Bronchial Leech Infestation in a 15-Year-Old Female

    PubMed Central

    Moslehi, Mohammad Ashkan; Imanieh, Mohammad Hadi

    2016-01-01

    Foreign body aspiration (FBA) is a common incidence in young children. Leeches are rarely reported as FBA at any age. This study describes a 15-year-old female who presented with hemoptysis, hematemesis, coughs, melena, and anemia seven months prior to admission. Chest X-ray showed a round hyperdensity in the right lower lobe. A chest computed tomography (CT) demonstrated an area of consolidation and surrounding ground glass opacities in the right lower lobe. Hematological investigations revealed anemia. Finally, bronchoscopy was performed and a 5 cm leech was found within the right B7-8 bronchus and removed by forceps and a Dormia basket. PMID:27752380

  3. Bronchial Leech Infestation in a 15-Year-Old Female.

    PubMed

    Moslehi, Mohammad Ashkan; Imanieh, Mohammad Hadi; Adib, Ali

    2016-01-01

    Foreign body aspiration (FBA) is a common incidence in young children. Leeches are rarely reported as FBA at any age. This study describes a 15-year-old female who presented with hemoptysis, hematemesis, coughs, melena, and anemia seven months prior to admission. Chest X-ray showed a round hyperdensity in the right lower lobe. A chest computed tomography (CT) demonstrated an area of consolidation and surrounding ground glass opacities in the right lower lobe. Hematological investigations revealed anemia. Finally, bronchoscopy was performed and a 5 cm leech was found within the right B7-8 bronchus and removed by forceps and a Dormia basket.

  4. [Bromo-Dragonfly poisoning of 18-year-old male].

    PubMed

    Nielsen, Visti Torbjørn; Høgberg, Lotte C G; Behrens, Jens Kristian

    2010-05-10

    Bromo-Dragonfly (BDF) is a designer drug chemically related to LSD and amphetamine. The first registration in Denmark was in October 2007. In the present case an 18-year-old man ingested about 2 ml BDF and developed acute psychosis. At the hospital the patient displayed, hyperpyrexia, tachycardia, tachypnea and hypertension. Because of severe hallucinations and agitation the patient was detained at the hospital and received symptomatic treatment with large doses of benzodiazepines. Four days after hospitalization, the patient discharged himself without significant symptoms or paraclinical findings.

  5. Granuloma inguinale in a 51-year-old man.

    PubMed

    Ornelas, Jennifer; Kiuru, Maija; Konia, Thomas; Larsen, Larissa

    2016-04-18

    Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. He was subsequently treated with trimethoprim/sulfamethoxazole with improvement in the ulcer. This case serves as a reminder to clinicians that although granuloma inguinale is rarely encountered in the US, it should still be suspected in patients with non-healing penile ulcers.

  6. Blowout Fracture in a 3-Year-Old

    PubMed Central

    Pluijmers, Britt I.; Koudstaal, Maarten J.; Paridaens, Dion; van der Wal, Karel G.H.

    2013-01-01

    A 3-year-old patient was referred to the oral and maxillofacial department with a fracture of the orbital floor. Due to the lack of clinical symptoms, a conservative approach was chosen. After 3 weeks, an enophthalmos developed. The orbital floor reconstruction was successfully performed through a transconjunctival approach. This case highlights the rarity of pure blowout fractures in young children. The specific presentation and diagnostics of orbital floor fractures in children and the related surgical planning and intervention are discussed. PMID:24436749

  7. Factitious purpura in a 10-year-old girl.

    PubMed

    Yamada, Kayo; Sakurai, Yoshihiko; Shibata, Mari; Miyagawa, Sachiko; Yoshioka, Akira

    2009-01-01

    We describe a 10-year-old girl who presented with bizarre purpura. Both congenital and autoimmune hemorrhagic disorders were excluded based on her past medical history and physical and laboratory findings. Child abuse was also ruled out as purpura continued to develop after child-family separation. Histologic examination of the skin lesions revealed disruption of collagen fiber bundles. This finding indicated application of external force, leading to a definitive diagnosis of factitious purpura. Although it is very rare in school-age children, the diagnosis of factitious purpura should be included in the differential diagnosis of purpura in children. Histologic analysis of skin biopsies may aid in establishing the diagnosis.

  8. Ashy dermatosis in an 8-year-old Indian child

    PubMed Central

    Keisham, Chitralekha; Sarkar, Rashmi; Garg, V. K.; Chugh, Shikha

    2013-01-01

    Ashy dermatosis is a disorder of pigmentation, characterized by asymptomatic symmetric ashy gray-colored macules, in the first to third decade of life. It can, however, affect children sometime. But, there is a paucity of similar cases in Indian children. We present a case of ashy dermatosis in an 8-year-old Indian girl who presented to skin OPD with areas of ashy pigmentation, which were distributed symmetrically. Skin biopsy was consistent with lichenoid pattern histology. This case has been reported to highlight the rarity of ashy dermatosis in Indian children. PMID:23439983

  9. Pulmonary nocardiosis in a 3-year-old child

    PubMed Central

    Holdaway, M. D.; Kennedy, J.; Ashcroft, T.; Kay-Butler, J. J.

    1967-01-01

    Until 1960, 179 cases of infection with Nocardia asteroides had been described in the world literature. Seventeen cases in children were reported by 1963. The organism is a common saprophyte in nature with probably a world-wide distribution. Infection can be primary but is more common in patients with underlying malignancy, auto-immune disease or preceding tuberculosis. Sulphonamides, particularly sulphadiazine, are the drugs of choice in treatment; the value of antibiotics is less clearly established. The indications for surgical treatment have not yet been defined. We record a further case of primary pulmonary nocardiosis in a 3-year-old child. Images PMID:6035802

  10. Odontogenic myxoma in a 52-year-old woman

    PubMed Central

    Ram, Hari; Mehta, Gagan; Kumar, Manoj; Lone, Parveen

    2014-01-01

    Odontogenic myxoma (OM) is a rare benign but locally aggressive tumour of the jaws. It is usually seen in the second to third decade of life. Women are more frequently affected than men and it has more predilections for the mandible rather than the maxilla. OM presents as an asymptomatic swelling in most of the cases. Owing to the non-capsulated and aggressive nature of OM, a high rate of recurrence has been reported. Here we present a case of OM in a 52-year-old woman managed by segmental mandibulectomy. Sign of recurrence was seen after 18 months of follow-up. PMID:24859552

  11. Ballpoint pen ingestion in a 2-year-old child.

    PubMed

    Rameau, Anaïs; Anand, Sumeet M; Nguyen, Lily H

    2011-07-01

    A 2-year-old girl ingested a ballpoint pen, which was found on chest x-ray to have lodged in the lower esophagus and stomach. The pen, which measured nearly 15 cm in length, was removed via rigid esophagoscopy without complication. To the best of our knowledge, this is the longest nonflexible foreign body ingested by a young child ever reported in the English-language literature. We describe the presentation of this case and the current guidelines for safety as enumerated in the Small Parts Regulations established by the U.S. Consumer Product Safety Commission.

  12. [A 74-year-old woman with macrocytic anemia].

    PubMed

    Picardi, A; Navajas, F; Spoto, S; Palma Modoni, A; De Galasso, L; Costantino, S

    2002-01-01

    A seventy-four years old woman is assessed for asthenia, fatigue, non ulcerous dyspepsia with macrocytic anemia. The patient's medical history taking in Binswanger disease--diagnosed 5 aa before-, epilepsy-2 aa before- and a previous episode of TVP of the left leg, suggested the hypothesis that a B12 deficiency, by a chronic gastritis, would involve an increase of homocysteine cause of the clinical manifestations of megaloblastic anemia, Binswanger disease, tardive epilepsy and previous TVP. The fisic and blood and instrumental exams confirmed the clinical diagnosis. The patient is having vitamin B12.

  13. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) watches as 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA, shakes hands with astronaut Dog Wheelock. Behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  14. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a laugh with VIP 10- year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  15. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) shares a light moment during his meeting with 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  16. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Ten-year-old Jonathan Pierce (second from right), who is garbed in a protective cooling suit, without the helmet, which was designed by NASA, poses with (left to right) NASA Administrator Dan Goldin, Mrs. Goldin, and astronaut Doug Wheelock. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  17. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (left) listens intently to 10-year- old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

  18. Trends in Developmental Skill Attainment among Japanese Three Year Olds: A Five-Year Comparative Study.

    ERIC Educational Resources Information Center

    Yamaguchi, Motomu; Tanaka, Hisae

    2002-01-01

    A mail survey was used to investigate 5-year trends in Japanese mothers' reports of their 3-year-olds' cognitive, psychomotor, and social developmental attainment. Findings indicated significant decreases in all domains, not attributable to changes in family structure, although scores were higher among children in nuclear families than in extended…

  19. Endometrial Adenocarcinoma in a 27-Year-Old Woman

    PubMed Central

    Fadhlaoui, Anis; Ben Hassouna, Jamel; Khrouf, Mohamed; Zhioua, Fethi; Chaker, Anis

    2010-01-01

    Background Endometrial adenocarcinoma usually occurs after menopause, but in 2%–14% of cases, it occurs in young patients (less than 40 years of age) who are eager to preserve their fertility. Its treatment includes hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy, and, in some cases, radiation therapy. Aim To describe a case of endometrial adenocarcinoma occurring in a young woman and to undertake a literature review of risk factors and therapeutic options proposed for young women wishing to preserve their fertility. Case We report a case of endometrial cancer in a 27-year-old woman treated for resistant menorrhagia and cared for in our department as well as in the Salah Azaiez Institute. Conclusion Endometrial adenocarcinoma rarely occurs in young women. In such cases, other therapeutic options can be proposed: progesterone therapy and LH-RH (Luteinzing-Hormone-Releasing-Hormone) agonists therapy in order to preserve fertility in younger patients. PMID:21769252

  20. Prevalence of mutans streptococci in one-year-old children.

    PubMed

    Grindefjord, M; Dahllof, G; Wikner, S; Hojer, B; Modeer, T

    1991-10-01

    Colonization with mutans streptococci was studied in 1095 1-year-old children living in suburban Stockholm. During a scheduled vaccination appointment at a child health centre, a bacterial sample was obtained from the child's tongue and a structured questionnaire was completed by the accompanying parent. Six percent of the subjects were colonized with mutans streptococci. The variables most strongly correlated with presence of mutans streptococci were: non-Swedish background, consumption of sugar-containing beverages at night and total consumption of sugar-containing beverages. The results indicate that, by the age of 1 year, maternally influenced behaviour patterns such as dietary habits that may predispose to early colonization of mutans streptococci are already established. Such early colonization with mutans streptococci may predict high caries risk in the primary dentition.

  1. The structure of executive function in 3-year-olds.

    PubMed

    Wiebe, Sandra A; Sheffield, Tiffany; Nelson, Jennifer Mize; Clark, Caron A C; Chevalier, Nicolas; Espy, Kimberly Andrews

    2011-03-01

    Although the structure of executive function (EF) during adulthood is characterized by both unity and diversity, recent evidence suggests that preschool EF may be best described by a single factor. The latent structure of EF was examined in 228 3-year-olds using confirmatory factor analysis. Children completed a battery of executive tasks that differed in format and response requirements and in putative working memory and inhibitory control demands. Tasks appeared to be age appropriate, with adequate sensitivity across the range of performance and without floor or ceiling effects. Tests of the relative fit of several alternative models supported a single latent EF construct. Measurement invariance testing revealed less proficient EF in children at higher sociodemographic risk relative to those at lower risk and no differences between boys and girls. At 3years of age, when EF skills are emerging, EF appears to be a unitary, more domain-general process.

  2. Mitochondrial DNA sequences from a 7000-year old brain.

    PubMed Central

    Pääbo, S; Gifford, J A; Wilson, A C

    1988-01-01

    Pieces of mitochondrial DNA from a 7000-year-old human brain were amplified by the polymerase chain reaction and sequenced. Albumin and high concentrations of polymerase were required to overcome a factor in the brain extract that inhibits amplification. For this and other sources of ancient DNA, we find an extreme inverse dependence of the amplification efficiency on the length of the sequence to be amplified. This property of ancient DNA distinguishes it from modern DNA and thus provides a new criterion of authenticity for use in research on ancient DNA. The brain is from an individual recently excavated from Little Salt Spring in southwestern Florida and the anthropologically informative sequences it yielded are the first obtained from archaeologically retrieved remains. The sequences show that this ancient individual belonged to a mitochondrial lineage that is rare in the Old World and not previously known to exist among Native Americans. Our finding brings to three the number of maternal lineages known to have been involved in the prehistoric colonization of the New World. Images PMID:3186445

  3. A 31-year-old pregnant woman with angioedema.

    PubMed

    Speck, Aimee L; Killen, Paul D; Greenhawt, Matthew J

    2015-01-01

    Angioedema is swelling of the deep layers of the dermis and subcutaneous tissue due to an increase in vascular permeability. Angioedema sometimes occurs concomitantly with urticaria and represents an allergic disease. In other cases, angioedema is not associated with an allergic condition. We present the case of a 31-year-old woman with new-onset angioedema in the setting of her first pregnancy. After detailed history, physical examination, and laboratory evaluation, a cause for her angioedema was found that had not been considered previously and had significant implications for future management, particularly in light of her current pregnancy. Because allergists are commonly called on to evaluate and treat angioedema, we should be aware of the many disease processes that can present with this symptom and be well-versed in the workup of new-onset angioedema.

  4. NASA Administrator Dan Goldin greets 100-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Astronaut Andy Thomas (left) greets 100-year-old Captain Ralph Charles, one of the VIPs attending the launch of STS-99. Charles also met NASA Administrator Dan Goldin. An aviator who has the distinction of being the oldest licensed pilot in the United States, Charles is still flying. He has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles watches all the Shuttle launches from his home in Ohio and his greatest wish is to be able to watch one in person from KSC.

  5. A 6-Year-Old With Leg Cramps.

    PubMed

    Jenssen, Brian P; Lautz, Andrew J; Orthmann-Murphy, Jennifer L; Yum, Sabrina W; Waanders, Angela; Fox, Elizabeth

    2015-10-01

    A 6-year-old girl presented with a history of leg pain and cramping that progressively worsened over a 2- to 3-week period of time. Her examination was notable for normal vital signs, limited range of motion of her left hip, and a limp. Inflammatory markers were slightly elevated, but the serum electrolytes, calcium, and magnesium, complete blood cell count and differential, and creatine kinase level were normal. She was hospitalized for further diagnostic evaluation and was noted to have abnormal muscle movements classified as myokymia (continuous involuntary quivering, rippling, or undulating movement of muscles). Electromyography confirmed the myokymia but did not reveal evidence of a myopathy or neuropathy, prompting additional evaluation for a systemic etiology.

  6. Scurvy in a 10-year-old boy.

    PubMed

    Cole, John A; Warthan, Molly M; Hirano, Stefanie A; Gowen, Clarence W; Williams, Judith V

    2011-01-01

    Scurvy, or hypovitaminosis C, is an uncommon condition that exists today primarily within certain unique populations-particularly the elderly subjects, patients with neurodevelopmental disabilities or psychiatric illnesses, or others with unusual dietary habits. Vitamin C is an essential nutrient in the human body, and is important in synthesizing collagen factor whose faulty production is responsible for most of the clinical manifestations of scurvy. These clinical manifestations can include dystrophic or corkscrew hairs, gingival hyperplasia, and weakened blood vessel walls, causing bleeding in the skin, joints, and other organs. Although rare in the Unites States, the presence of scurvy should not be forgotten because of its presence among susceptible populations. Moreover, with its diagnosis, treatment and cure is one of the simplest in modern medicine. We report a case of scurvy in a 10-year-old autistic child.

  7. A 54-year-old woman with degenerative back pain.

    PubMed

    Tuck, Claire M

    2010-03-01

    Back pain is a common symptom: up to 70% of UK adults experience this symptom by the age of 60 and most have moderate to severe pain. Back pain accounted for 12% of consultations to traditional acupuncturists in 2001 and is one of the most common reasons for consultation with an acupuncturist. This case report concerns a 54-year-old woman with metastatic breast cancer and degenerative lower back pain, which remained painful despite intensive pharmaceutical management and facet joint injection and was ultimately successfully managed with two 30 min acupuncture treatments 2 weeks apart, using eight points on the BL meridians. Acupuncture treatment using tender points was later trialled for neuropathic pain secondary to local recurrence in her mastectomy scar, however this was unsuccessful and inpatient hospice admission for further intensive pharmaceutical management was required.

  8. Lynch syndrome in a 15-year-old boy.

    PubMed

    Bodas, A; Pérez-Segura, P; Maluenda, C; Caldés, T; Olivera, E; Díaz-Rubio, E

    2008-10-01

    Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, dominantly inherited, is characterized by the development of a variety of cancers due to germline mutations in DNA mismatch repair genes (MMR). This syndrome was diagnosed in a 15-year-old boy because his father and grandmother were also found to have the same kind of cancer. Microsatellite instability prompted a search for germline mutations in the MLH1, MSH2, MSH6, and PMS2 genes. Use of immunohistochemical staining for MMR proteins, genomic sequencing, and deletion studies, evidenced MSH2 axonal deletion. Neoplastic lesions of colon are most often encountered in the adult population but can, on rare occasions, be found in younger patients. We would like to emphasize the importance of suspecting Lynch syndrome and performing genetic studies, even in young patients, when there is a family history of colorectal cancer.

  9. 72 year-old man with new seizure while dancing.

    PubMed

    Gutiérrez Morales, Julio César; Gutiérrez Morales, Sandra Eugenia; Astudillo González, Aurora

    2009-04-01

    Metastasis of an extracranial malignant neoplasm to a meningioma is a rare event.We report a case of a 72-year-old man who presented abruptly with a grand mal seizure. Neuroradiological examination revealed an extraaxial lesion located in the posterior right frontal convexity with poorly defined boundaries. Histological and immunohistochemical examination showed that the lesion was a meningothelial meningioma harboring metastatic renal cell carcinoma.The MRI could be indicative but not specific of this type of lesion.Some cases of intracranial meningiomas containing metastatic carcinomas have been published, but to our knowledge only five cases of renal cell carcinoma metastasizing to a meningioma have been reported. Possible explanations for this type of "tumor in tumor" lesion are reviewed.

  10. Neurogenic muscle hypertrophy in a 12-year-old girl.

    PubMed

    Zutelija Fattorini, Matija; Gagro, Alenka; Dapic, Tomislav; Krakar, Goran; Marjanovic, Josip

    2017-01-01

    Muscular hypertrophy secondary to denervation is very rare, but well-documented phenomena in adults. This is the first report of a child with neurogenic unilateral hypertrophy due to S1 radiculopathy. A 12-year-old girl presented with left calf hypertrophy and negative history of low back pain or trauma. The serum creatinine kinase level and inflammatory markers were normal. Magnetic resonance imaging showed muscle hypertrophy of the left gastrocnemius and revealed a protruded lumbar disc at the L5-S1 level. The protruded disc abuts the S1 root on the left side. Electromyography showed mild left S1 radiculopathy. Passive stretching and work load might clarify the origin of neurogenic hypertrophy but there is still a need for further evidence. Clinical, laboratory, magnetic resonance imaging and electromyography findings showed that S1 radiculopathy could be a cause of unilateral calf swelling in youth even in the absence of a history of back or leg pain.

  11. Pyomyositis in a 5-year-old child.

    PubMed

    Romeo, S; Sunshine, S

    2000-07-01

    We present a case of pyomyositis in an otherwise healthy 5-year-old child that underscores the potential for serious, life-threatening complications. Pyomyositis of the gluteal, psoas, and iliacus muscles was associated with osteomyelitis, septic arthritis, a large inferior vena cava thrombus, septic pulmonary emboli, and eventual pneumonia. Primary pyomyositis is a purulent infection of striated muscle thought to be caused by seeding from a transient bacteremia. The focal infection typically forms an abscess that generally responds to intravenous antibiotics and occasionally requires adjunctive computed tomography-guided aspiration and drainage. This localized infectious process rarely produces further sequelae unless treatment is delayed. Pyomyositis is rare in healthy individuals and requires a high clinical suspicion in patients who present with fever, leukocytosis, and localized pain.

  12. Extrinsic Rewards Diminish Costly Sharing in 3-Year-Olds.

    PubMed

    Ulber, Julia; Hamann, Katharina; Tomasello, Michael

    2016-07-01

    Two studies investigated the influence of external rewards and social praise in young children's fairness-related behavior. The motivation of ninety-six 3-year-olds' to equalize unfair resource allocations was measured in three scenarios (collaboration, windfall, and dictator game) following three different treatments (material reward, verbal praise, and neutral response). In all scenarios, children's willingness to engage in costly sharing was negatively influenced when they had received a reward for equal sharing during treatment than when they had received praise or no reward. The negative effect of material rewards was not due to subjects responding in kind to their partner's termination of rewards. These results provide new evidence for the intrinsic motivation of prosociality-in this case, costly sharing behavior-in preschool children.

  13. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) greets 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  14. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) presents a bag of special gifts to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  15. NASA Administrator Dan Goldin greets 10-year-old VIP.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    NASA Administrator Dan Goldin (center) talks to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

  16. [Fascicular ventricular tachycardia in a 49-year-old patient].

    PubMed

    Bellmann, Barbara; Nagel, Patrick; Tscholl, Verena; Roser, Mattias; Rillig, Andreas

    2016-06-01

    We report a 49-year-old patient who presented with tachycardia in our emergency room. The 12-lead ECG showed a wide complex tachycardia with a heart rate of 234 beats per minute. After structural heart disease was excluded via echocardiography, coronary angiography and magnetic resonance imaging, an electrophysiological study was performed. During programmed ventricular stimulation, a fascicular tachycardia was induced, which was successfully treated by radiofrequency ablation. Fascicular ventricular tachycardia is a rare tachycardia that occurs in patients without structural heart disease. Radiofrequency ablation can be performed safely and shows a high success rate. Differential diagnoses of fascicular ventricular tachycardias are substrate-based ventricular tachycardia and supraventricular tachycardia.

  17. Parotid sialolithiasis in a two-year-old boy

    PubMed Central

    Kim, Do Hoon; Song, Woo Sun; Kim, Yeong Jin

    2013-01-01

    Sialolithiasis is caused by the obstruction of a salivary gland or its excretory duct by the formation of calcareous concretions or sialoliths; this results in salivary ectasia and provokes subsequent dilation of the salivary gland. Sialolithiasis is relatively common, accounting for 30% of salivary diseases; however, it is rarely observed in childhood. This case report describes a 2-year-old male patient who complained of a painful swelling over the right cheek, and presented with palpable stones and pus discharge from the orifice of the right Stensen's duct. Computerized tomography of the neck confirmed the diagnosis, and the patient received intravenous empiric antibiotics combined with intraoral sialolithotomy. We also provide a review of the spectrum of concepts regarding the pathogenesis, diagnosis, and treatment of sialolithiasis. PMID:24244214

  18. Slope restoration for a 100-year old canal

    SciTech Connect

    Skaggs, R.L.; Lewis, S.W.; Liebersbach, D.C.

    1995-12-31

    Turlock Irrigation District (TID) is located in the northern portion of the fertile San Joaquin Valley of California. TID`s primary water supply is conveyed from the 100-year-old LaGrange Diversion Dam via their historic Upper Main Canal. The original canal was constructed by excavating into slate bedrock for the uphill (cut) bank, and constructing unmortared rock walls and rock fill for the downhill (fill) embankment; the excavation was then lined with concrete. Soil fill raises of the downhill embankment over the last 30 years have reduced the slope stability to unacceptable levels in the steepest embankment areas. In March of 1994, two surficial slides prompted investigation of the long term embankment stability in the Warehouse Slide Area. Based on results of analysis for various stabilization scenarios, TID chose a stabilization method which included: (1) excavation of an access bench below the existing canal, (2) installation of steel pipe piles through the existing rock fill and into the bedrock, (3) construction of a mechanically stabilized earth (MSE) retaining wall and (4) construction of a soil-cement canal roadway pavement. The design was chosen by the owner because of cost competitiveness compared to other design alternatives and because the construction sequence allowed uninterrupted use of the canal. By using local river cobble for the MSE wall facing material, TID met the desired 50-year design life of the repair while maintaining the area`s historic visual features.

  19. Oral squamous cell carcinoma in a 10 year old boy.

    PubMed

    Khan, M H; Naushad, Q N

    2011-01-01

    Squamous cell carcinoma of the oral cavity a type of Oral Cancer in young patients is a very rare occurrence particularly during the first decade of life. Oral cancer is predominantly an aggressive neoplasm of middle-aged people where 96% of the patients are more than 40 years of age and it occurs mainly due to the excessive consumption of tobacco and alcohol. In South-East Asia it has a higher rate of occurrence than the rest of the world, partly due to increased consumption of chewing tobacco and various harmful spices, areca nuts and betel quids. These rare varieties of aggressive neoplasm commonly affect tongue and lip. This report describes a case of squamous cell carcinoma in a 10 year old boy who had an exophytic type of granulomatous lesion with some indurated borders which diffusely involved the left side of the hard palate, alveolar mucosa, left maxillary antrum and aggressively emerged within the left orbit by engulfing the left inferior rectus muscle. The purpose of this case report is to provide information that younger group can suffer from oral squamous cell carcinoma though it is very rare and this younger group would appear to have a biologically more aggressive tumor and they require more complex treatment. The role of more aggressive initial therapy must be considered.

  20. [Rapidly progressive glomerulonephritis in a 68-year-old man].

    PubMed

    Rubio, E; Acevedo, M

    2004-01-01

    A 68-year-old male with macroscopic hematuria and constitutional symptoms as fever and weight loss. There was nothing interesting in the anamnesis or in the physical exploration. The laboratory test had an elevation of creatinine of 4 mg/dL and ten days before it had been 1.4 mg/dL. In the urine analysis: proteinuria of 1.5 G/24 h, and hematuria. On the second day we made a renal biopsy where we could seen segmental glomerular necrosis and crescent fromation in 80% of the glomeruli. In the immune study c-ANCA anti-PR3 was positive. In the complementary studies we didn't find other organs affected. With the diagnosis of pauci-immune glomerulonephritis limited to the kidney we began treatment with corticosteroids and cyclophosphamide. As the renal function was severely affected the patient needed one dialysis session. We began with 1 g intravenous methylprednisolone daily for 3 days followed by oral prednisone 60 mg daily tapering to 10 mg daily by 3 months. This was combined with 150 mg oral cyclophosphamide daily. Seven plasma exchanges were performed. At the beginning of treatment creatinine was 7 mg/dL, it was decreasing rapidly and three week after cretinine was 3 mg/Dl and he was asymptomatic. One year after treatment, creatinine is 1.4 mg/dL and the urine analysis is normal, C-ANCA are negative.

  1. 25 Years Old Women With Inflammatory Low Back Pain

    PubMed Central

    Soltani, Zahra; Davatchi, Fereydon

    2016-01-01

    Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological type of malignant lymphomas (approximately 30% of cases). DLBCL is highly curable through chemotherapy. Rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy as the most frequent of care for first - DLBCL therapy, improves long-term survival of patients effectively. Case report: A young female (25 years old) complained about pain in her right back for two years. She was suffering from backache with priority in the right and contracture in mornings. Sacroiliac joint seemed normal but lytic and sclerotic lesions and also density changing of L5 and humerus head was revealed by CT scan. Biopsy was taken from the iliac bone and diffuse large B cell lymphoma was diagnosed. Conclusion: Chronic pains especially in axial skeleton, pelvis area and main joints must be taken seriously and examined by CT scan and MRI. If no particular issue was reported primarily while the pain was remained, a complete diagnosis BMB associated with PET must be applied. Despite of dependency on diagnosis the treatment by CHOP in association with rituximab is the most recommended chemotherapy alternative for patients with DLBCL. PMID:27594751

  2. [Oral hygiene customs in 6-12 year old schoolchildren].

    PubMed

    Hernández-Martínez, César Tadeo; Medina-Solís, Carlo Eduardo; Robles-Bermeo, Norma Leticia; Mendoza-Rodríguez, Martha; Veras-Hernández, Miriam; De la Rosa-Santillana, Rubén; Escoffié-Ramírez, Mauricio; Márquez-Rodríguez, Sonia

    2014-01-01

    OBJECTIVE. To characterize utilization of oral hygiene devices and customs in schoolchildren. MATERIAL AND METHODS. We performed a cross-sectional study in 1,404 schoolchildren (6- 12 year olds) from 14 public schools in Pachuca, Hidalgo, México, using a questionnaire for sociodemographic variables and 1) Tooth brushing frequency (<1/d vs. at least 1/d), 2) Use of toothpaste (not always vs. always), 3) Flossing (never, does not know vs. at least 1/week), 4) Use of mouthwash (never, does not know vs. at least 1/week). Analyses were performed with nonparametric tests. RESULTS. Mean age was 8.97 ± 1.99 years; 50.1% were male. Prevalence of utilization of oral hygiene devices and associated customs were 85.5% tooth brushing, 90.9% toothpaste, 19.4% flossing, and 28.2% mouthwash. Only 11.8% of participants reported utilization in all 4 categories. We observed differences (p < 0.05) across sexes only in the use of toothpaste, as women used it more often. Differences across age were observed (p < 0.05) for tooth brushing (younger children brushed more often) and flossing (older children flossed more often). CONCLUSIONS. Tooth brushing was the oral hygiene practice more often performed in this sample, with other frequencies being relatively low. There were differences by age and sex across some variables.

  3. Giant Cell Fibroma in a Two-Year-Old Child

    PubMed Central

    Mello-Moura, Anna Carolina Volpi; Bonini, Gabriela Azevedo Vasconcelos Cunha; Del Conte Zardetto, Cristina Giovannetti; Wanderley, Marcia Turolla

    2016-01-01

    The giant cell fibroma is a benign nonneoplastic fibrous tumor of the oral mucosa. It occurs in the first three decades of life in the mandibular gingiva, predominantly, showing predilection for females. This article reports a case of giant cell fibroma in a 2-year-old girl, which is an uncommon age for this lesion. The patient was brought for treatment at the Research and Clinical Center of Dental Trauma in Primary Teeth, where practice for the Discipline of Pediatric Dentistry (Faculty of Dentistry, University of São Paulo, Brazil) takes place. During clinical examination, a tissue growth was detected on the lingual gingival mucosa of the lower right primary incisors teeth. The lesion was excised under local anesthesia and submitted to histological examination at the Oral Pathology Department of the Faculty of Dentistry, University of São Paulo, which confirmed the diagnosis of giant cell fibroma. There was no recurrence after 20 months of monitoring. This instance reinforces the importance of oral care from the very first months of life in order to enable doctors to make precocious diagnosis and offer more appropriate treatments for oral diseases, as well as to promote more efficient oral health in the community. PMID:27822394

  4. The "strong" RNA world hypothesis: fifty years old.

    PubMed

    Neveu, Marc; Kim, Hyo-Joong; Benner, Steven A

    2013-04-01

    This year marks the 50(th) anniversary of a proposal by Alex Rich that RNA, as a single biopolymer acting in two capacities, might have supported both genetics and catalysis at the origin of life. We review here both published and previously unreported experimental data that provide new perspectives on this old proposal. The new data include evidence that, in the presence of borate, small amounts of carbohydrates can fix large amounts of formaldehyde that are expected in an environment rich in carbon dioxide. Further, we consider other species, including arsenate, arsenite, phosphite, and germanate, that might replace phosphate as linkers in genetic biopolymers. While linkages involving these oxyanions are judged to be too unstable to support genetics on Earth, we consider the possibility that they might do so in colder semi-aqueous environments more exotic than those found on Earth, where cosolvents such as ammonia might prevent freezing at temperatures well below 273 K. These include the ammonia-water environments that are possibly present at low temperatures beneath the surface of Titan, Saturn's largest moon.

  5. Breast mass in a 69-year-old woman

    SciTech Connect

    Hermann, G.; Schwartz, I.S.; Slater, G.

    1986-02-21

    A 69-year-old woman was initially seen with constant abdominal pain in the epigastrium and right upper quadrant, with nausea and vomiting of three days' duration. On examination, moderate tenderness and guarding in the right upper quadrant of the abdomen were noted. A leukocytosis of 11,000/cu mm, with a mild shift to the left, was present. Findings from a sonogram and hepatobiliary scan were consistent with a diagnosis of acute cholecystitis for which intravenous (IV) antibiotic therapy was instituted. Results of radiological studies performed on the second hospital day showed a small-bowel obstruction. On surgical exploration, a gangrenous segment of the terminal ileum was resected and an end-to-end anastomosis was performed. The resected bowel demonstrated hemorrhagic infarction with evidence of focal organizing venous thrombosis in the mesentery. The patient was initially started on a regimen of IV heparin and then switched to oral coumarin. On the fourth day of coumarin therapy, massive swelling, tenderness, and erythema were noted to involve the entire right breast. Six months later, the patient was readmitted because of an acute pulmonary embolism. A residual 4x5-cm mass was present in the central portion of the right breast. The overlying skin was slightly retracted. Mammography showed an extensive masslike density behind the right nipple, with evidence of periareolar retraction. Coumarin-induced mammary necrosis was diagnosed.

  6. Pulmonary adiaspiromycosis in a two year old girl.

    PubMed Central

    Nuorva, K; Pitkänen, R; Issakainen, J; Huttunen, N P; Juhola, M

    1997-01-01

    A case of disseminated bilateral pulmonary adiaspiromycosis is reported in a two year old Finnish girl. She recovered from this rare infection after treatment with amphotericin B. She is the first human case of adiaspiromycosis in Scandinavia and she is the youngest child with this disease reported so far. Electron microscopy showed that the three layers of the spore wall were not typical; rather, there seemed to be a gradual transition between the main wall zones, which may be split into an indefinite number of thin layers. Varying numbers and thicknesses were seen with different staining methods, and in different spores. Diagnosis relies on recognition of the fungus in a pulmonary biopsy specimen, because there are no reliable serological tests and culture of the fungus is time consuming and not always successful. It was thought that this patient had become infected as a result of contact with soil dust containing the spores in the yard surrounding her home, and as a result of her mother's work in a large garden shop. Images PMID:9059367

  7. Unexplained weight loss in an 80-year-old woman.

    PubMed

    Taylor, Imogen Aleksandra; Gill, Isaac; Harripaul, Azad

    2015-01-23

    An 80-year-old woman presented with long-standing history of weight loss and malnutrition, which had caused her to become reliant on the use of a wheelchair. Her symptoms were initially attributed to her medical comorbidities, however, during admission it became apparent that she had been suffering from depression and had gone on to develop an eating disorder. Eating disorders are most common in young adults but can affect all age groups, including the elderly population. The diagnosis is rarely considered in such patients and easily overlooked, especially when in the presence of chronic conditions and cognitive decline. A pre-existing psychiatric issue, most often depression, may also be present in this age group. There are no current treatment methods targeting patients in this population, who may not respond as effectively to the available strategies directed at young adults. It is important to always consider an eating disorder as a contributor or direct cause of unexplained weight loss in elderly patients.

  8. [Unexplained weight gain in a 41-year-old woman].

    PubMed

    Harsch, I A; Hahn, E G

    2010-03-01

    A 41-year-old female was admitted to our clinic due to weight gain and facial edema. The patient also reported hair loss, amenorrhea and the formation of striae. The laboratory diagnostics ensured the diagnosis of Cushing's syndrome. Unfortunately, the patient was among the 5-10% of patients in whom neither laboratory testing nor imaging revealed the source of the cortisol excess. Due to the dramatic decrease of her general condition, and the appearance of hypertension and diabetes mellitus we chose to refer the patient to bilateral minimally invasive adrenalectomy. The advantage of this therapeutic approach is, that it is a definitive treatment that provides immediate control of hypercortisolism. As disadvantage, the resultant permanent hypoadrenalism requires a lifelong glucocorticoid and mineralocorticoid replacement therapy. Furthermore, given that the problem was caused by occult pituitary microadenoma, Nelson's syndrome has to be considered. As only one adrenal could be excised due to technical reasons, the underlying pathology is thus not solved. In spite of this, the patient's general condition improved dramatically without need for replacement therapy. As the mortality of patients with persistent moderate hypercortisolism is increased 3,8- to 5 fold, mainly due to cardiovascular reasons, thorough surveillance for signs of recurrence is mandatory to be ready for quick intervention.

  9. Phacomatosis pigmentokeratotica (Happle) in a 23-year-old man.

    PubMed

    Wollenberg, Andreas; Butnaru, Cristina; Oppel, Tilmann

    2002-01-01

    Phacomatosis pigmentokeratotica is a rare but highly characteristic disease defined by the occurrence of an organoid naevus with sebaceous differentiation, a speckled-lentiginous naevus and other associated anomalies. It is probably caused by the twin-spot phenomenon. We report on a 23-year-old male electrician with 10 irregularly shaped, sharply demarcated, brownish-yellow papillomatous plaques following Blaschko's lines, as well as 6 large, sharply demarcated, round to oval, slightly greyish macules with pewit-egg-like dots, involving both buttocks, the right thigh, the right knee, the right pectoral region and the upper back. A moderate hyperhidrosis of the palms, soles and axillae was noted. All routine blood tests and laboratory findings, including chest X-ray, ECG, abdominal ultrasound, ocular and neural examination were unrevealing. Phacomatosis pigmentokeratotica may be associated with dysaesthesia, segmental hyperhidrosis, mild mental retardation, epileptic seizures, deafness, ptosis, strabismus or muscular weakness. In our patient, only slight hyperhidrosis was present, whereas all other associated anomalies could be excluded.

  10. A 51-year-old man with sudden unexpected death.

    PubMed

    Donelan, Kent J; Randall, Brad B; Newby, Paul E

    2009-01-01

    We report an unusual case of a 51-year-old man who died suddenly and was found to have an intraventricular and subarachnoid hemorrhage secondary to acute hemorrhage within a choroid plexus xanthogranuloma. This is a highly unusual source of bleeding and to our knowledge has not been previously described in the literature. The man was discovered deceased on the bathroom floor of his home and an autopsy was ordered by the county coroner. Examination of the brain showed diffuse subarachnoid blood accumulation over the base of the brain in a symmetric distribution. A large amount of subarachnoid blood was especially noted near the brainstem at the level of the fourth ventricle foramina. Sections of the lateral left ventricle showed acute non-organizing hemorrhage within the ventricle and adjacent choroid plexus. Microscopically, a nodular focus seen grossly in the left lateral ventricle revealed marked chronic xanthogranulomatous inflammation with extensive cholesterol clefts, foreign body reaction, and focal calcifications. A periphery of normal choroid plexus was identified around the nodule. There was evidence of both recent and remote hemorrhage.

  11. A 37-year-old mechanic with multiple chemical sensitivities.

    PubMed

    Kipen, H M; Fiedler, N

    2000-04-01

    A 37-year-old heating, ventilation, and air-conditioning mechanic developed respiratory, musculoskeletal, and central nervous system symptoms associated with a variety of odorous environmental chemicals. Organic disease was not evident, but the patient was distressed by these symptoms and was at risk for becoming disabled by them. His symptoms fit broadly into the condition recognized as multiple chemical sensitivity. Multiple chemical sensitivity is a diagnostic term for a group of symptoms without demonstrated organic basis. The symptoms are characteristic of dysfunction in multiple organ systems, they increase and decrease according to exposure to low levels of chemical agents in the patient's environment, and they sometimes occur after a distinct environmental change or insult such as an industrial accident or remodeling. Although traditional medical organizations have not agreed on a definition for this syndrome, it is being increasingly recognized and makes up an increasing percentage of the caseload at occupational and environmental medicine clinics. Although there is often dispute about whether the symptoms have a functional or organic basis, an informed approach to evaluation, diagnosis, and management and a careful assessment of impairment, disability, and work relatedness are necessary. Careful exclusion of organic causes is critical, and this should be followed by a judicious approach to coping with symptoms.

  12. A 37-year-old mechanic with multiple chemical sensitivities.

    PubMed Central

    Kipen, H M; Fiedler, N

    2000-01-01

    A 37-year-old heating, ventilation, and air-conditioning mechanic developed respiratory, musculoskeletal, and central nervous system symptoms associated with a variety of odorous environmental chemicals. Organic disease was not evident, but the patient was distressed by these symptoms and was at risk for becoming disabled by them. His symptoms fit broadly into the condition recognized as multiple chemical sensitivity. Multiple chemical sensitivity is a diagnostic term for a group of symptoms without demonstrated organic basis. The symptoms are characteristic of dysfunction in multiple organ systems, they increase and decrease according to exposure to low levels of chemical agents in the patient's environment, and they sometimes occur after a distinct environmental change or insult such as an industrial accident or remodeling. Although traditional medical organizations have not agreed on a definition for this syndrome, it is being increasingly recognized and makes up an increasing percentage of the caseload at occupational and environmental medicine clinics. Although there is often dispute about whether the symptoms have a functional or organic basis, an informed approach to evaluation, diagnosis, and management and a careful assessment of impairment, disability, and work relatedness are necessary. Careful exclusion of organic causes is critical, and this should be followed by a judicious approach to coping with symptoms. PMID:10753098

  13. The merger of the 60-year old Jupiter's White Ovals

    NASA Astrophysics Data System (ADS)

    Sanchez-Lavega, Agustin

    2000-07-01

    Three White Ovals {nicknamed BC, DE, FA} formed in Jupiter's atmosphere in 1939-1940. Two of these anticyclones {BC and DE} merged in February 1998, generating a new large oval BE {A.Sanchez-Lavega et al., Icarus, Vol. 142, 116, 1999}.Unfortunately the phenomenon took place during the solar conjunction so the details of the event were lost. In March 2000 a second merger occurred. Visual and infrared observations carried out with the 1-meter planetary telescope at Pic-du-Midi Observatory {France} and with the 3.5-meter NASA Infrared Telescope Facility {Mauna Kea, Hawaii} respectively, showed the merger of the 60-year old FA with the recently formed BE . Each was about 2/3 the size of the Earth. Although the observations were performed under difficult conditions because of the proximity of Jupiter to the Sun, we gathered good information of the rich phenomenology that accompanied the merger. To complete this set of observations we need to retrieve as soon as possible, the dynamics, internal texture, cloud morphology and vertical structure of the new vortex and its surroundings. This information, together with our ground-based data and expected data from the Galileo spacecraft fly in May 20 fly, could be decisive to understand the nature of anticyclonic vortices and the structure of its atmosphere well below the cloud level.

  14. Epiploic appendagitis in a 27-year-old man

    PubMed Central

    Uehara, Ryohei; Isomoto, Hajime; Yamaguchi, Naoyuki; Ohnita, Ken; Fujita, Fumihiko; Ichikawa, Tatsuki; Takeshima, Fuminao; Yamaguchi, Tetsuji; Uetani, Masataka; Nakao, Kazuhiko

    2011-01-01

    Summary Background Epiploic appendagitis is an ischemic infarction of an epiploic appendage caused by torsion or spontaneous thrombosis of the central draining vein. Epiploic appendagitis is self-limited without surgery, and it is imperative for clinicians to be familiar with this entity. Case Report A healthy 27-year-old man was admitted due to acute right lower quadrant abdominal pain. Physical examination showed focal abdominal tenderness with slight rebound tenderness. Laboratory tests showed leukocytosis and an increased serum C-reactive protein level. Computed tomography (CT) showed a fatty ovoid pericolonic mass measuring 12 mm in diameter, with a circumferential hyperdense ring that abutted on the ascending colon and was surrounded by ill-defined fat stranding with a hyperdense ring. These findings were diagnostic of primary epiploic appendagitis. The patient was given high-dose antibiotics due to the secondary inflammation involving the parietal peritoneum. Conclusions Epiploic appendagitis presents with an abrupt onset of focal abdominal pain and tenderness without significant guarding or rigidity; it is an uncommon and difficult diagnosis. With awareness of this condition, however, evaluation by CT can provide an accurate diagnosis of epiploic appendagitis, distinguishing it from conditions with clinically overlapping manifestations. PMID:21959616

  15. Patterns of Weight Control Behavior among 15 year old Girls

    PubMed Central

    Balantekin, Katherine N.; Birch, Leann L.; Savage, Jennifer S.

    2015-01-01

    Objective The objectives were to identify and predict patterns of weight control behavior in 15 year old (yo) girls and to examine weight control group differences in energy intake. Method Subjects included 166 girls assessed every 2 years (ys) from age 5 to 15. Latent class analysis was used to identify patterns of weight control behaviors. Antecedent variables (e.g. inhibitory control at 7ys), and concurrent variables (e.g. BMI and dietary intake at 15ys) were included as predictors. Assessments were a combination of survey, interview, and laboratory measures. Results LCA identified four classes of weight control behaviors, Non-dieters (26%), and three dieting groups: Lifestyle (16%), Dieters (43%), and Extreme Dieters (17%). Levels of restraint, weight concerns, and dieting frequency increased across groups, from Non-dieters to Extreme Dieters. BMI at 5ys and inhibitory control at 7ys predicted weight control group at 15ys; e.g. with every one-point decrease in inhibitory control, girls were twice as likely to be Extreme Dieters than Non-dieters. Girls in the Extreme Dieters group were mostly classified as under-reporters, and had the lowest self-reported intake, but ate significantly more in the laboratory. Discussion Among 15yo girls, “dieting” includes a range of both healthy and unhealthy behaviors. Risk factors for membership in a weight control groups are present as early as 5ys. Patterns of intake in the laboratory support the view that lower reported energy intake by Extreme Dieters is likely due under-reporting as an intent to decrease intake, not actual decreased intake. PMID:26284953

  16. Sharing Telescopes With 10-Year Olds to Celebrate the International Year of Astronomy

    NASA Astrophysics Data System (ADS)

    Lyons, Daniel Jonathan; Slater, T. F.; Slater, S. J.; in Astronomy, Cognition; Physics; Earth sciences Research CAPER Team

    2009-05-01

    Precisely four hundred years ago, Italian scientist Galileo's observations of the heavens forever and profoundly altered the way we view our place in the Universe. Throughout 2009, children across Wyoming are joining in a United Nations proclaimed International Year of Astronomy celebration. To commemorate 400 years of the telescope in advancing our understanding of the Universe through astronomy, our goal is that every 10-year old child in Wyoming will experience the excitement and wonder of looking through their very own telescope to observe majestic rings surrounding Saturn, deep craters on the Moon, countless stars lining the Milky Way, brilliant phases of Venus, and orbiting moons of Jupiter. This is being accomplished by a massive, state-wide collaborative effort bringing the collective energy and enthusiasm of professional scientists, amateur astronomers, local teachers, and community outreach enthusiasts together to spark an interest in science among Wyoming's children. Our strategy to bring a telescope to every Wyoming 10-year old child started first with a major year-long fundraising campaign. We estimate the cost of an individual telescope, constructed specifically for the 2009 International Year of Astronomy celebration, to be approximately $13 per child. With 6,489 (in 2007) 10-year old children in Wyoming, this amounts to less than $100,000 as a fund raising goal. University of Wyoming faculty are training teachers in how to use telescopes and how to integrate the excitement of astronomy across the curriculum. To teach children how to use their telescopes, volunteers from around the state are hosting star parties at schools, county fairs, and other regularly scheduled community celebrations.

  17. Sharing the Stars: Bringing Telescopes to 10-year Olds for International Year of Astronomy

    NASA Astrophysics Data System (ADS)

    Slater, S. J.

    2008-12-01

    Precisely four hundred years ago, Italian scientist Galileo's observations of the heavens forever and profoundly altered the way we view our place in the Universe. He dramatically increased our thinking about the size of the known Universe by using his telescope and initiated one of the most important scientific revolutions in history. Throughout 2009, children across Wyoming are joining in a United Nations proclaimed International Year of Astronomy celebration. To commemorate 400 years of the telescope in advancing our understanding of the Universe through astronomy, our goal is that every 10-year old child in Wyoming will experience the excitement and wonder of looking through their very own telescope to observe majestic rings surrounding Saturn, deep craters on the Moon, countless stars lining the Milky Way, brilliant phases of Venus, and orbiting moons of Jupiter. This is being accomplished by a massive, state-wide collaborative effort bringing the collective energy and enthusiasm of professional scientists, amateur astronomers, local teachers, and community outreach enthusiasts together to spark an interest in science among Wyoming's children. Our strategy to bring a telescope to every Wyoming 10-year old child started first with a major year-long fundraising campaign. We estimate the cost of an individual telescope, constructed specifically for the 2009 International Year of Astronomy celebration, to be approximately 13 per child. With 6,489 (in 2007) 10- year old children in Wyoming, this amounts to less than 100,000 as a fund raising goal. University of Wyoming faculty are training teachers in how to use telescopes and how to integrate the excitement of astronomy across the curriculum. To teach children how to use their telescopes, volunteers from around the state are hosting star parties at schools, county fairs, and other regularly scheduled community celebrations.

  18. Teaching Styles of Israeli Four-Year-Olds and Their Mothers: A Cross-Cultural Comparison.

    ERIC Educational Resources Information Center

    Feshbach, Norma D.

    The relationship between social class and patterns of reinforcement used by pre-school Israeli boys and girls and their mothers was investigated. Thirty lower and 30 middle class mothers instructed their own four year old in a simple task. These four year olds had previously taught a three year old a comparable task. Middle class children used…

  19. School and the 17-Year-Old: A Comparison of Career Development Skills of 17-Year-Olds Attending School and Those Not Attending.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO.

    National performance for 17-year-olds in school, 17-year-olds not in school and young adults aged 26-35 in the area of career and occupational development (COD) was assessed to determine whether or not education status and career development skills are related. Within each of the groups, performance of various subgroups was examined, defined by…

  20. Prevention of Persistent Human Papillomavirus Infection by an HPV16/18 Vaccine: A Community-Based Randomized Clinical Trial in Guanacaste, Costa Rica

    PubMed Central

    Herrero, Rolando; Wacholder, Sholom; Rodríguez, Ana C.; Solomon, Diane; González, Paula; Kreimer, Aimee R.; Porras, Carolina; Schussler, John; Jiménez, Silvia; Sherman, Mark E.; Quint, Wim; Schiller, John T.; Lowy, Douglas R.; Schiffman, Mark; Hildesheim, Allan

    2011-01-01

    Target groups for human papillomavirus (HPV) vaccination are controversial. We evaluated vaccine efficacy (VE) against 1-year persistent infection, stratified by age and sexual behavior, among young women in Costa Rica. We randomized 7,466 healthy women 18 to 25 years of age to HPV16/18 or hepatitis A vaccine (follow-up, 50.4 months). According-to-protocol (ATP) cohorts included compliant HPV-negative women; intention-to-treat (ITT) included all randomized women. ATP VE was 90.9% (95% CI, 82.0–95.9) against HPV16/18 infections, 44.5% against HPV31/33/45 (95% CI, 17.5–63.1), and 12.4% (95% CI, −3.2 to 25.6) against any oncogenic infection. Overall ITT VE against HPV16/18 infections was 49.0%, but ATP and ITT VE almost reached 100% in year 4 of follow-up. ATP efficacy against HPV16/18 was similar by age, but ITT VE was greatest among youngest women (68.9% among those 18–19 years of age; 21.8% among those 24–25 years of age) and 79.8% among virgins. Among previously unexposed women, vaccination is highly efficacious against HPV16/18 and partially against HPV31/33/45. Vaccination is most effective in women and girls before they initiate sexual activity, with programmatic and individual decision implications. PMID:22586631

  1. Impact of an HPV6/11/16/18 L1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with HPV16/18 infection.

    PubMed

    Haupt, Richard M; Wheeler, Cosette M; Brown, Darron R; Garland, Suzanne M; Ferris, Daron G; Paavonen, Jorma A; Lehtinen, Matti O; Steben, Marc; Joura, Elmar A; Giacoletti, Katherine E D; Radley, David R; James, Margaret K; Saah, Alfred J; Sings, Heather L

    2011-12-01

    The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 randomized, placebo-controlled, efficacy trials (Protocols 013 and 015). Vaccine or placebo was given at day 1, month 2 and 6. Women were tested for HPV6/11/16/18 DNA and antibodies at day 1. We focus on the subset of women who were seropositive and DNA positive to HPV16 or HPV18 prevaccination. Incidence is expressed as the number of women with an endpoint per 100 person-years-at-risk. In total, 419 vaccine and 446 placebo recipients were both seropositive and DNA positive to HPV16 or HPV18 prevaccination and had at least one follow-up visit. In Protocol 013, the incidence of HPV16/18-related CIN2-3/AIS among these women was 10.9 in the vaccine arm and 7.0 in the placebo arm (vaccine efficacy = -54.9; 95% CI: -181.7, 13.0). In Protocol 015, the incidence of HPV16/18-related CIN2-3/AIS was 5.5 in the vaccine arm and 6.2 in the placebo arm (vaccine efficacy = 12.2%; 95% CI: -29.8, 40.9). These data suggest HPV vaccination neither reduces nor enhances progression to HPV16/18-related high grade cervical lesions, and cervical cytology screening and corresponding management should continue as per local recommendations. Ultimately, population-based surveillance of vaccinated individuals beyond these clinical trials will be required to further address questions regarding the impact of vaccination in women exposed to vaccine HPV types before vaccination.

  2. 51-year-old woman with double vision.

    PubMed

    Browning, Lisa; Leach, John; Watts, Christopher; Kuker, Wilhelm; Stacey, Richard

    2008-04-01

    A 51-year-old woman presented with a 2-month history of double vision and numbness around her left ear. She subsequently became unsteady on her feet and developed further cranial nerve abnormalities, before complaining of headache, nausea and vomiting. Imaging revealed features suggestive of two intracranial lesions; one non-contrast-enhancing high-signal area in the cerebellum with associated calcification, and a second contrast-enhancing low-signal area in association with the fourth ventricle, and at surgery there were two apparent components to the tumor. The histopathological features were those of a low-grade, focally calcified tumor comprising atypical ganglion and glial cells with interspersed Rosenthal fibres. Mitotic figures were not seen, and there was no necrosis. An infiltrate of small reactive lymphocytes was interspersed among the neoplastic cells. Immunohistochemistry revealed expression of synaptophysin by many of the dysplastic ganglion cells, with some co-expressing neurofilament protein and occasionally glial fibrillary acidic protein (GFAP). Several of the dysplastic ganglion cells also expressed CD34. The glial cell population was highlighted by GFAP. Ki-67 (MIB-1) activity was not noted among the neoplastic populations--the few positive nuclei in these areas were those of interspersed reactive CD3-positive T lymphocytes. In addition, at the edge of one of the biopsies was a dense infiltrate of mitotically-active large atypical CD 20-positive B lymphocytes, among which the Ki-67 (MIB-1) labeling index reached 80%. The final diagnosis was diffuse large B cell lymphoma arising within a ganglioglioma of the cerebellum, and this is believed to be the first reported case.

  3. Neurocysticercosis in a 23-year-old Chinese man

    PubMed Central

    Vecchio, Rosa Fontana Del; Pinzone, Marilia Rita; Nunnari, Giuseppe; Cacopardo, Bruno

    2014-01-01

    Patient: Male, 23 Final Diagnosis: Neurocysticerosis Symptoms: Diplopia • fever • headache • insomnia • neck stiffness • vomiting Medication: Albendazole Clinical Procedure: — Specialty: Neurology Objective: Challenging differential diagnosis Background: Neurocysticercosis is a brain infection caused by the larval stage of the tapeworm Taenia (T.) solium. It is the most important parasitic disease of the human central nervous system and represents the most common cause of acquired epilepsy in developing countries. Case Report: Here, we report the case of a 23-year-old Chinese man who presented to the emergency department with a 7-day history of helmet headache radiating to the nuchal region and associated with vomiting, confusion, and fever. Cerebrospinal fluid (CSF) was clear, with increased pressure, lymphocytic pleocytosis, decreased glucose, and increased protein levels. Bacterial antigen detection test on CSF was negative, as were CSF bacterial and fungal cultures. Despite broad-spectrum antibiotic and antiviral therapy, the patient still complained of insomnia, diplopia, headache, neck stiffness, and pain in the sacral region. A second LP was performed and CSF had the same characteristics as the first LP. A brain and spinal cord MRI revealed widespread arachnoiditis and small septated cysts with CSF-like signal in the cisterna magna, within the fourth ventricle, and at the level of L3–L4. Cysticercus-specific immunoglobin G antibodies were detected by ELISA in the CSF. The patient received albendazole (15 mg/kg/day) and dexamethasone (5 mg/day) for 4 weeks, with progressive resolution of neurological symptoms. Conclusions: This case shows that, even if rare, neurocysticercosis may be responsible for meningeal symptoms and should be included in the differential diagnosis, especially in patients from endemic countries. PMID:24459541

  4. Obturator externus abscess in a 9-year-old child

    PubMed Central

    de Bodman, Charlotte; Ceroni, Dimitri; Dufour, Justine; Crisinel, Pierre-Alex; Bregou-Bourgeois, Aline; Zambelli, Pierre-Yves

    2017-01-01

    Abstract Rationale: Obturator pyomyositis is a rare condition in children. Diagnosis is often delayed because of its rarity, and the vagaries of its presentation cause it to be easily be missed. Physicians should therefore familiarize themselves with this condition and consider it as a possible differential diagnosis in patients presenting with an acutely painful hip. Inflammatory syndrome is also frequent among sufferers and the MRI is a very sensitive diagnostic tool for obturator pyomyositis. Additionally, joint fluid aspirations and blood cultures are also useful in identifying the pathogen. The appropriate antibiotic therapy provides a rapid regression of symptoms during the early stage of pyomyositis. In cases of MRI-confirmed abscess, surgical treatment is indicated. Patient concerns: Our report focuses on a case of obturator pyomyositis in a 9-year-old boy. The child was febrile for 5 days and could only manage to walk a few steps. His hip range of motion was restricted in all directions. In addition, the patient had presented pain and swelling of his right elbow for a day, with a restriction of motion in the joint. There was a clear inflammatory syndrome. A diagnosis of hip and elbow septic arthritis was suspected, and the child underwent joint aspiration of the both cited joints. The aspiration of the elbow returned pus. Conversely, no effusion was found in the hip aspiration. The administration of empiric intravenous antibiotherapy was started. Diagnoses: An MRI revealed an osteomyelitis of the ischio-pubic area associated with a subperiosteal abscess. Interventions: Subsequently, 3 days after elbow arthrotomy, a surgical treatment was performed on the patient's right hip in order to evacuate the subperiosteal abscess and muscular collection because of the persistence of the patient's symptoms and inflammatory syndrome despite susceptible intravenous antibiotics. Postsurgery the patient showed steady improvement. Lessons: Such cases demonstrate how

  5. Five-year-olds are willing, but 4-year-olds refuse, to trust informants who offer new and unfamiliar labels for parts of the body.

    PubMed

    Luu, Betty; Rosnay, Marc de; Harris, Paul L

    2013-10-01

    This study employed the selective trust paradigm to examine how children interpret novel labels when compared with labels they already know to be accurate or inaccurate within the biological domain. The participants--3-, 4-, and 5-year-olds (N=144)--were allocated to one of three conditions. In the accurate versus inaccurate condition, one informant labeled body parts correctly, whereas the other labeled them incorrectly (e.g., calling an eye an "arm"). In the accurate versus novel condition, one informant labeled body parts accurately, whereas the other provided novel labels (e.g., calling an eye a "roke"). Finally, in the inaccurate versus novel condition, one informant labeled body parts incorrectly, whereas the other offered novel labels. In subsequent test trials, the two informants provided conflicting labels for unfamiliar internal organs. In the accurate versus inaccurate condition, children sought and endorsed labels from the accurate informant. In the accurate versus novel condition, only 4- and 5-year-olds preferred the accurate informant, whereas 3-year-olds did not selectively prefer either informant. In the inaccurate versus novel condition, only 5-year-olds preferred the novel informant, whereas 3- and 4-year-olds did not demonstrate a selective preference. Results are supportive of previous studies suggesting that 3-year-olds are sensitive to inaccuracy and that 4-year-olds privilege accuracy. However, 3- and 4-year-olds appear to be unsure as to how the novel informant should be construed. In contrast, 5-year-olds appreciate that speakers offering new information are more trustworthy than those offering inaccurate information, but they are cautious in judging such informants as being "better" at providing that information.

  6. One-Year-Olds Warn Others about Negative Action Outcomes

    ERIC Educational Resources Information Center

    Knudsen, Birgit; Liszkowski, Ulf

    2013-01-01

    Warning others is a paradigm case of communicative helping and prospective action understanding. The current study addressed the ontogeny of warning in infants' gestural communication. We found that 12- and 18-month-olds ("n" = 84) spontaneously warned an adult by pointing out to her an aversive object hidden in her way…

  7. Multiple Granuloma Annulare in a 2-year-old Child

    PubMed Central

    Siddalingappa, Karjigi; Murthy, Sambasiviah Chidambara; Herakal, Kallappa; Kusuma, Marganahalli Ramachandra

    2015-01-01

    Granuloma annulare is a benign, self-limiting, inflammatory and granulomatous disease of unknown etiology occurring in both adults and children. An 18-month-old male child had multiple progressive annular plaques over the lower extremities. Clinical and histopathological features were consistent with granuloma annulare. Localized granuloma annulare is the most common form in children. We report a young child with multiple, progressive granuloma annulare over the lower extremities. PMID:26677301

  8. The role of imagination in facilitating deductive reasoning in 2-, 3- and 4-year-olds.

    PubMed

    Richards, C A; Sanderson, J A

    1999-09-30

    When 4- and 6-year-olds are cued to use their imagination, they can overcome the belief bias effect and demonstrate deductive reasoning ability on syllogisms containing contrary-to-fact material. This study tested whether 2- and 3-year-olds could also reason with incongruent syllogisms when encouraged to use their imagination. Eighty-four 2-, 3- and 4-year-olds were randomly assigned to one of four conditions: no cue, word cue, fantasy planet or imagery. Children were then presented with six syllogistic reasoning problems containing incongruent information. In the imagination conditions, 2- and 3-year-olds performed as competently as 4-year-olds. The findings are discussed in relation to other research which suggests that under certain circumstances 2- and 3-year-olds have the capacity for counterfactual thinking.

  9. Study on Growth Rhythm of Juveniles Cistolemmys Flavomarginata for One and Two Years Old

    NASA Astrophysics Data System (ADS)

    Huang, Bin

    Growth of one and two year old Cistolemmys flavomarginata is studied. In natural temperature and under artificial feeding condition, juvenile turtles grow for 180 days in Xinyang, one year old turtle average body weight increased from 18.1 g to 54.5 g, the relative growth rate is 204.1%, the absolute growth rate is 0.21. two year old turtle average body weight increased from 46.8 g to 101.1 g, the relative growth rate is 115.98%, the absolute growth rate is 0.30. But two year old turtle growth rate is slower than that of one year old turtle. The body weight, carapace length, carapace width, plastron length, plastron width and carapace high are correlated positively to daily age. The body weight growth equations of one and two year old turtles are deduced. Compared with other reptiles, whole growth cycle is grasped systemically by the growth patterns.

  10. Growth and Your 13-to 18-Year-Old

    MedlinePlus

    ... A Parent's Guide to Surviving the Teen Years Male Reproductive System Your Child's Checkup: 14 Years Your Child's Checkup: ... Height? When Will I Start Developing? Growth Problems Male Reproductive System Everything You Wanted to Know About Puberty Help! ...

  11. One year test-retest reliability of neurocognitive baseline scores in 10- to 12-year olds.

    PubMed

    Moser, Rosemarie Scolaro; Schatz, Philip; Grosner, Emily; Kollias, Kelly

    2017-01-01

    How often youth athletes 10-12 years of age should undergo neurocognitive baseline testing remains an unanswered question. We sought to examine the test-retest reliability of annual ImPACT data in a sample of middle school athletes. Participants were 30 youth athletes, ages 10-12 years (Mean = 11.6, SD = 0.6) selected from a larger database of 10-18 year old athletes, who completed two consecutive annual baseline evaluations using the online version of ImPACT. Athlete assent and parental consent were obtained for all participants. Assessments were conducted either individually or in small groups of 2 to 3 athletes, under the supervision of a neuropsychologist or post-doctoral fellow. Test-retest coefficients were as follows: Verbal Memory .71, Visual Memory .35, Visual Motor Speed .69, Reaction Time .34. Intra-class Correlation Coefficients (single/average) were as follows: Verbal Memory .70/.83, Visual Memory .35/.52, Visual Motor Speed .69/.82, Reaction Time .34/.50. Regression-based measures to correct for practice effects revealed that only a small percentage of cases fell outside 90 and 95% confidence intervals, reflecting stability across assessments. Findings indicate that test-retest reliability of Verbal Memory and Visual Motor Speed are generally stable in 10-12 year old athletes. Nevertheless, Visual Memory Index, Reaction Time Index, and Symptom Checklist scores appear to be less reliable over time, especially compared to published data on high school athletes, suggesting the utility of re-testing on an annual basis in this younger age group.

  12. Employment of Minors. A Guide for 14- through 17-year-olds, Their Parents and Employers.

    ERIC Educational Resources Information Center

    Oregon State Bureau of Labor and Industry, Portland.

    This guide on the employment of minors is intended for 14- through 17-year olds, their parents, and employers. It first lists requirements for employers who hire minors. Then it lists the jobs that 14- and 15-year-old workers can do, both the types of businesses that would hire them and examples of the kinds of jobs that 14- and 15-year-olds may…

  13. Reduced Prevalence of Vulvar HPV16/18 Infection Among Women Who Received the HPV16/18 Bivalent Vaccine: A Nested Analysis Within the Costa Rica Vaccine Trial

    PubMed Central

    Lang Kuhs, Krystle A.; Gonzalez, Paula; Rodriguez, Ana Cecilia; van Doorn, Leen-Jan; Schiffman, Mark; Struijk, Linda; Chen, Sabrina; Quint, Wim; Lowy, Douglas R.; Porras, Carolina; DelVecchio, Corey; Jimenez, Silvia; Safaeian, Mahboobeh; Schiller, John T.; Wacholder, Sholom; Herrero, Rolando; Hildesheim, Allan; Kreimer, Aimée R.

    2014-01-01

    Background Vaccine efficacy (VE) against vulvar human papillomavirus (HPV) infection has not been reported and data regarding its epidemiology are sparse. Methods Women (n = 5404) age 22–29 present at the 4-year study visit of the Costa Rica Vaccine Trial provided vulvar and cervical samples. A subset (n = 1044) was tested for HPV DNA (SPF10/LiPA25 version 1). VE against 1-time detection of vulvar HPV16/18 among HPV vaccinated versus unvaccinated women was calculated and compared to the cervix. Prevalence of and risk factors for HPV were evaluated in the control arm (n = 536). Results Vulvar HPV16/18 VE (54.1%; 95% confidence interval [CI], 4.9%–79.1%) was comparable to cervix (45.8%; 95% CI, 6.4%–69.4%). Vulvar and cervical HPV16 prevalence within the control arm was 3.0% and 4.7%, respectively. Independent risk factors for vulvar HPV were similar to cervix and included: age (adjusted odds ratio [aOR] 0.5 [95% CI, .3–.9] ≥28 vs 22–23]); marital status (aOR 2.3 [95% CI, 1.5–3.5] single vs married/living-as-married); and number of sexual partners (aOR 3.6 [95% CI, 1.9–7.0] ≥6 vs 1). Conclusions In this intention-to-treat analysis, VE against vulvar and cervical HPV16/18 were comparable 4 years following vaccination. Risk factors for HPV were similar by anatomic site. Clinical Trials Registration NCT00128661. PMID:24958910

  14. Tectal pineal cyst in a 1-year-old girl.

    PubMed

    Plowey, Edward D; Vogel, Hannes; Yeom, Kristen W; Jung, Henry; Chao, Kevin; Edwards, Michael S B

    2014-03-01

    Glial cysts of the pineal gland can frequently be found in adults and children, but only rarely do they enlarge to become clinically relevant. We report a unique presentation of a pineal cyst in the midbrain tectum of a 16-month-old girl who initially presented with ptosis and strabismus. Preoperative imaging studies and intraoperative findings revealed no continuity between the tectal cyst and the pineal gland proper. We surmise that this tectal pineal cyst may have arisen from duplicated pineal gland tissue.

  15. 18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for...

  16. 18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for...

  17. 18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for...

  18. 18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for...

  19. 18 CFR 16.18 - Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Annual licenses for projects subject to sections 14 and 15 of the Federal Power Act. 16.18 Section 16.18 Conservation of Power... Projects Subject to Sections 14 and 15 of the Federal Power Act § 16.18 Annual licenses for...

  20. Pooled analysis of large and long-term safety data from the human papillomavirus-16/18-AS04-adjuvanted vaccine clinical trial programme

    PubMed Central

    Angelo, Maria-Genalin; David, Marie-Pierre; Zima, Julia; Baril, Laurence; Dubin, Gary; Arellano, Felix; Struyf, Frank

    2014-01-01

    Purpose The purpose of this study is to further evaluate the safety of the human papillomavirus (HPV)-16/18-AS04-adjuvanted vaccine (HPV-16/18-vaccine Cervarix®, GlaxoSmithKline, Belgium) through a pooled analysis of data from 42 completed/ongoing clinical studies. Methods Unsolicited adverse events (AEs) were reported for 30 days after each dose. Medically significant conditions, serious AEs (SAEs), potential immune-mediated diseases (pIMDs) and pregnancy outcomes were captured until study completion. Events leading to subject withdrawal were reviewed. Relative risks compared incidences of spontaneous abortion and pIMDs in controlled studies. Results Thirty one thousand one hundred seventy-three adolescent girls/women received HPV-16/18-vaccine alone (HPV group), 2166 received HPV-16/18-vaccine coadministered with another vaccine and 24 241 were controls. Mean follow-up was 39 months (range 0–113.3). Incidences of unsolicited AEs reported within 30 days after any dose were similar between HPV and Control groups (30.8%/29.7%). During the entire study period, reports of medically significant conditions (25.0%/28.3%) and SAEs (7.9%/9.3%) were also similarly distributed between groups. Deaths were rare: HPV (alone/coadministered) n = 25, controls n = 20 (n = 18 in blinded groups). pIMDs within 1 year were reported by 0.2% of HPV-16/18 vaccinees and controls. For each pIMD event category, no increased relative risks were reported for HPV-16/18 vaccinees versus controls. Coadministration did not change the overall safety profile. Pregnancy outcomes and withdrawal rates were similar between groups. Conclusions Analysis of safety data arising from 57 580 subjects and 96 704 HPV-16/18-vaccine doses shows that the incidences and distribution of AEs were similar among HPV-16/18-vaccine recipients and controls. No new safety signals were identified. The data confirm previous findings that HPV-16/18-vaccine has an acceptable benefit-risk profile in adolescent girls and

  1. Changing Tune: Reconceptualizing Music with Under Three Year Olds

    ERIC Educational Resources Information Center

    Young, Susan

    2005-01-01

    Recent years have seen a rapid increase in opportunities for very young children in the UK to participate in musical activity. These opportunities are provided by a range of music professionals who are expanding their work into the early years sector. Support for this increase in early childhood music draws on recent research into aspects of…

  2. Growth and Your 2- to 3-Year-Old

    MedlinePlus

    ... effective in significantly increasing their final adult height. Constitutional growth delay (delayed puberty). Although they are usually ... about age 2 or 3 years, kids with constitutional growth delay will grow at a normal childhood ...

  3. Medical Care and Your 6- to 12-Year-Old

    MedlinePlus

    ... Looking for Health Lessons? Visit KidsHealth in the Classroom What Other Parents Are Reading Your Child's Development ( ... ask their own questions about their health and changing body. At yearly exams, kids are weighed and ...

  4. Medical Care and Your 2- to 3-Year-Old

    MedlinePlus

    ... infection Common Medical Problems Young children have an average of 6 to 8 colds a year, and also may have several bouts of diarrhea and vomiting, as well as ear infections. Sleep problems and behavior or discipline concerns are very ...

  5. Medical Care and Your 1- to 2-Year-Old

    MedlinePlus

    ... the Classroom What Other Parents Are Reading Your Child's Development (Birth to 3 Years) Feeding Your 1- to ... your doctor if you have concerns about your child's development. When to Call the Doctor By now you ...

  6. Fitness and Your 6- to 12-Year-Old

    MedlinePlus

    ... KidsHealth in the Classroom What Other Parents Are Reading Your Child's Development (Birth to 3 Years) Feeding ... activities that feel right. Most kids won't mind a daily dose of fitness as long as ...

  7. Medical Care and Your 4- to 5-Year-Old

    MedlinePlus

    ... varicella) vaccine The flu vaccine , given before flu season each year, also is recommended. Other vaccines might ... disturbances , such as nightmares . Kids also might have growing pains in their calves at night. Your doctor ...

  8. Fraser syndrome in a 96-year-old female.

    PubMed

    Impallomeni, Mario; Subramanian, Deepak; Mahmood, Nazim; Illes, Joseph; Joseph, Illes

    2006-11-01

    Fraser syndrome is an autosomal recessive disorder in which the life expectancy is <1 year. The main features are cryptophthalmos, ear, nose and skeletal malformations, syndactyly, laryngeal stenosis and malformation of the uro-genital system, lungs, liver and central nervous system (CNS). We report the clinical, laboratory and post-mortem findings of this condition in an elderly woman aged 96 years. She is the oldest known patient with Fraser syndrome.

  9. Efficacy of human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine against cervical infection and precancer in young women: final event-driven analysis of the randomized, double-blind PATRICIA trial.

    PubMed

    Apter, Dan; Wheeler, Cosette M; Paavonen, Jorma; Castellsagué, Xavier; Garland, Suzanne M; Skinner, S Rachel; Naud, Paulo; Salmerón, Jorge; Chow, Song-Nan; Kitchener, Henry C; Teixeira, Julio C; Jaisamrarn, Unnop; Limson, Genara; Szarewski, Anne; Romanowski, Barbara; Aoki, Fred Y; Schwarz, Tino F; Poppe, Willy A J; Bosch, F Xavier; Mindel, Adrian; de Sutter, Philippe; Hardt, Karin; Zahaf, Toufik; Descamps, Dominique; Struyf, Frank; Lehtinen, Matti; Dubin, Gary

    2015-04-01

    We report final event-driven analysis data on the immunogenicity and efficacy of the human papillomavirus 16 and 18 ((HPV-16/18) AS04-adjuvanted vaccine in young women aged 15 to 25 years from the PApilloma TRIal against Cancer In young Adults (PATRICIA). The total vaccinated cohort (TVC) included all randomized participants who received at least one vaccine dose (vaccine, n = 9,319; control, n = 9,325) at months 0, 1, and/or 6. The TVC-naive (vaccine, n = 5,822; control, n = 5,819) had no evidence of high-risk HPV infection at baseline, approximating adolescent girls targeted by most HPV vaccination programs. Mean follow-up was approximately 39 months after the first vaccine dose in each cohort. At baseline, 26% of women in the TVC had evidence of past and/or current HPV-16/18 infection. HPV-16 and HPV-18 antibody titers postvaccination tended to be higher among 15- to 17-year-olds than among 18- to 25-year-olds. In the TVC, vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or greater (CIN1+), CIN2+, and CIN3+ associated with HPV-16/18 was 55.5% (96.1% confidence interval [CI], 43.2, 65.3), 52.8% (37.5, 64.7), and 33.6% (-1.1, 56.9). VE against CIN1+, CIN2+, and CIN3+ irrespective of HPV DNA was 21.7% (10.7, 31.4), 30.4% (16.4, 42.1), and 33.4% (9.1, 51.5) and was consistently significant only in 15- to 17-year-old women (27.4% [10.8, 40.9], 41.8% [22.3, 56.7], and 55.8% [19.2, 76.9]). In the TVC-naive, VE against CIN1+, CIN2+, and CIN3+ associated with HPV-16/18 was 96.5% (89.0, 99.4), 98.4% (90.4, 100), and 100% (64.7, 100), and irrespective of HPV DNA it was 50.1% (35.9, 61.4), 70.2% (54.7, 80.9), and 87.0% (54.9, 97.7). VE against 12-month persistent infection with HPV-16/18 was 89.9% (84.0, 94.0), and that against HPV-31/33/45/51 was 49.0% (34.7, 60.3). In conclusion, vaccinating adolescents before sexual debut has a substantial impact on the overall incidence of high-grade cervical abnormalities, and catch-up vaccination up to 18 years

  10. Cerebral infarction in a 24-year-old pilot.

    PubMed

    Ohashi, Koichiro; Nakanishi, Kuniaki; Miyajima, Daijiro; Fukushima, Koji; Shirotani, Toshiki; Kuwamura, Keiichi; Tong, Andrew

    2003-10-01

    Ischemic stroke is a rare event in young adults. We report on a 24-yr-old pilot with cerebral infarction of undetermined etiology, temporally associated with chain smoking. The patient exhibited dysphasia, stupor (confused consciousness), and right facial-nerve palsy. Computed-tomography revealed a low-density area in the left insular cortex. Cerebroangiography showed severe stenosis in a branch of the left middle cerebral artery. After admission, the patient made a rapid and uneventful recovery within 72 h. MRI showed an area of hyperintensity on T2-weighted images 2 mo after the attack. Based on the hyperintense area on FLAIR (fluid attenuated inversion recovery sequence) images obtained in MRI performed 10 mo after the attack, we diagnosed a cerebral infarction. In the Japan Air Self-Defense Force, cerebral infarction is an aeromedically disqualifying condition. However, in the evaluation 2 mo after the attack, differentiation from reversible ischemic neurological deficit was difficult. We discuss the criteria used for diagnosis and the risk factors for cerebral infarction in young adults, as well as the aeromedical disposition of young pilots.

  11. [Pervasive refusal syndrome in a 12-year-old boy].

    PubMed

    Christensen, Ann-Margrethe Rønholt; Thelle, Thomas

    2011-04-18

    We describe a formerly healthy boy aged 12 years with a two-month history of severe coughing and abdominal pain leading to school absence. During admission he became increasingly immobilised and unable to perform activities of daily life, and finally simply adopted the foetal position and needed gastric tube feeding. Gradual restitution was achieved during a 34-month stay as an inpatient at a child psychiatric department. He fulfilled all proposed criteria of the pervasive refusal syndrome. At a follow-up at the age of 20 years, he was pursuing a normal independent life with his girlfriend and was attending higher education.

  12. Human papilloma virus 16-18 infection and cervical cancer in Mexico: a case-control study.

    PubMed

    Hernández-Avila, M; Lazcano-Ponce, E C; Berumen-Campos, J; Cruz-Valdéz, A; Alonso de Ruíz, P P; Gonźalez-Lira, G

    1997-01-01

    Cervical cancer (CC) is one of the principal public health problems in Mexico. The national mortality rate due to CC was estimated at 21.8 per 100,000 among women over 15 years old during 1994. Despite this high incidence little is known in Mexico about the risk factors for CC. The objectives of the study were to evaluate the association between CC and HPV types 16 and 18 in women living in Mexico City. From August, 1990 to December, 1992, a case-control study was carried out in the metropolitan area of Mexico City. HPV 16-18 types were determined in a sample of 148 CC cases and 204 controls randomly selected from a sample frame representative of the metropolitan area of Mexico City. Sixty cases corresponded to in situ CC and 88 cases to the invasive phase. Determination of HPV 16 and 18 types was done by polymerase chain reaction using primers specific to E6/E7. Results showed that 48.3% of in situ CC cases and 48.8% of invasive CC cases were positive for HPV 16 while only 13.2% were positive among the 204 controls. Association between HPV 16 infection in the in situ cancer cases had an estimated odds ratio (OR) of 5.17 (95% CI 2.60-10.51). In the invasive cervical cancer cases, association between HPV 16 infection and invasive CC in this sample had an OR of 3.84 (95% CI 2.04-7.22). For the total sample, the estimated OR was 5.48 (95% CI 3.07-9.62). In the total sample, those women with a strong positive reaction to PCR were associated with a large increase in the risk, OR of 38.0 (95% CI 8.66-167.1). The prevalence the HPV 18 was 6.7%, only observed in the invasive cervical cancer cases. At present there is general consensus that HPV is the principal causal agent in C C etiology. This study intends to contribute to the knowledge concerning the etiology of cervical cancer. However, it is necessary to consider that the single most effective tool in the reduction of mortality due to cervical cancer has been the Pap test. Secondary prevention has proven to be highly

  13. 29 CFR 570.129 - Limited driving of automobiles and trucks by 17-year-olds.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Limited driving of automobiles and trucks by 17-year-olds... Amended Exemptions § 570.129 Limited driving of automobiles and trucks by 17-year-olds. Section 13(c)(6... employment, perform the occasional and incidental driving of automobiles and trucks on public highways...

  14. 29 CFR 570.129 - Limited driving of automobiles and trucks by 17-year-olds.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Limited driving of automobiles and trucks by 17-year-olds... Amended Exemptions § 570.129 Limited driving of automobiles and trucks by 17-year-olds. Section 13(c)(6... employment, perform the occasional and incidental driving of automobiles and trucks on public highways...

  15. 29 CFR 570.129 - Limited driving of automobiles and trucks by 17-year-olds.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Limited driving of automobiles and trucks by 17-year-olds... Amended Exemptions § 570.129 Limited driving of automobiles and trucks by 17-year-olds. Section 13(c)(6... employment, perform the occasional and incidental driving of automobiles and trucks on public highways...

  16. 29 CFR 570.129 - Limited driving of automobiles and trucks by 17-year-olds.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Limited driving of automobiles and trucks by 17-year-olds... Amended Exemptions § 570.129 Limited driving of automobiles and trucks by 17-year-olds. Section 13(c)(6... employment, perform the occasional and incidental driving of automobiles and trucks on public highways...

  17. The Semiotic Landscape and 3-Year-Olds' Emerging Understanding of Multimodal Communication Practices

    ERIC Educational Resources Information Center

    Yamada-Rice, Dylan

    2014-01-01

    This article considers the impact of the increasing use of the visual mode in texts found in urban landscapes on two 3-year-olds' understanding of communication practices. The data discussed are taken from a study into a group of 3- to 6-year-olds' interaction with and emerging comprehension of the visual mode and its connection to writing in…

  18. Brief Report: Screening Tool for Autism in Two-Year-Olds (STAT): Development and Preliminary Data.

    ERIC Educational Resources Information Center

    Stone, Wendy L.; Coonrod, Elaine E.; Ousley, Opal Y.

    2000-01-01

    A study examined the validity of the Screening Tool for Autism in Two-Year-Olds (STAT) as a stage 2 screening instrument in a clinic-based sample of two-year-olds with autism (n=12) and with nonautistic developmental disorders (n=21). Results provide preliminary support for the utility of the STAT as an early screening of autism. (Contains…

  19. The Young Child Learns: A Guide for Four-Year-Olds.

    ERIC Educational Resources Information Center

    Corpus Christi Independent School District, TX.

    The purpose of this teaching guide is to orient preschool teachers to the unique needs and abilities of the four-year-old child and to offer a suggested program of pre-kindergarten activities. Specific capabilities characteristic of the four-year-old are listed, followed by the scope of the preschool program in the areas of cognitive development,…

  20. Social Context Effects in 2- and 4-Year-Olds' Selective versus Faithful Imitation

    ERIC Educational Resources Information Center

    Yu, Yue; Kushnir, Tamar

    2014-01-01

    This study asked whether children's tendency to imitate selectively (ignore causally unnecessary actions) versus faithfully ("overimitate" causally unnecessary actions) varies across ages and social contexts. In the first experiment, 2-year-olds and 4-year-olds were randomly assigned to play 1 of 3 prior games with a demonstrator: a…

  1. Effect of Core Training on 16 Year-Old Soccer Players

    ERIC Educational Resources Information Center

    Afyon, Yakup Akif

    2014-01-01

    Core trainings have been widely used by trainers recently in order to improve performance of soccer players. In this context, the aim of this study is to examine the effect of core training on some motoric capabilities of 16 years old soccer players. Thirty certified soccer players who were 16 years old from B.B. Bodrumspor Club in 2013-2014…

  2. Five- to Twelve-Year-Olds' Control of Movement Velocity in a Dynamic Collision Avoidance Task

    ERIC Educational Resources Information Center

    te Velde, Arenda F.; van der Kamp, John; Savelsbergh, Geert J. P.

    2008-01-01

    We investigated age-related differences in a dynamic collision avoidance task that bears a resemblance to pedestrian road crossing. Five- to seven-year-old children, ten- to twelve-year-old children and adults were instructed to push a doll across a small-scale road between two toy vehicles, which approached one after the other. We analysed the…

  3. Kienböck's disease in a 12-year-old girl.

    PubMed

    De Smet, Luc

    2003-08-01

    A case of avascular necrosis of the lunate in a 12-year-old girl is described. Conservative treatment resulted in a clinically normal wrist at three years' follow-up, despite obvious radiological changes.

  4. Early Adolescence: Understanding the 10 to 15 Year Old.

    ERIC Educational Resources Information Center

    Caissy, Gail A.

    Early adolescence, the period from 10 to 15 years, is a significant transitional period in human development, marking the crossroads between childhood and young adulthood. This book is designed as a guide for parents, teachers, or anyone else who has contact with and who would like to better understand early adolescent children. The chapters in…

  5. Development of Anticipatory Visual Search in One-Year-Olds.

    ERIC Educational Resources Information Center

    Shimada, Shoko; Sano, Ryogoro

    The purpose of this study was to longitudinally examine the development of anticipatory visual search and to find out the effects of preceding experiences upon the search during the second year of life. The sample consisted of 18 Japanese firstborn nonretarded children from middle-class families who were individually tested at 11, 12, 14, 16, 22,…

  6. Families of 30-35-Year Olds with Down's Syndrome

    ERIC Educational Resources Information Center

    Carr, Janet

    2005-01-01

    Background: The families of a population sample of people with Down's syndrome (DS), and of their non-disabled controls, have been followed since early childhood, and the families have now been seen again as their sons and daughters reached age 30 and 35 years. Methods: A semi-structured interview schedule was used, including items from the…

  7. Growth and Your 13-to 18-Year-Old

    MedlinePlus

    ... is a time of dramatic change for both boys and girls. Hormone-driven changes are accompanied by growth spurts ... ages 12 and 15. The growth spurt of boys is, on average, about 2 years later than that of girls. By age 16, most boys have stopped growing, ...

  8. Acquired myopia in 11-year-old children.

    PubMed

    Peckham, C S; Gardiner, P A; Goldstein, H

    1977-02-26

    Children who had acquired myopia by the age of 11 years were identified from a nationally representative sample. There were no overall sex differences in its occurrence but myopia was more common in children from non-manual families than in those from manual families. Short-sighted children were more likely to come from small families and to be of higher birth order than children with normal vision, and these associations held within each social class. At 11 years myopic children showed striking advantages in educational performance over their normal-sighted peers, as judged by tests of reading, arithmetic, and general ability. After adjustments had been made for social background, this age gain still amounted to over one year. Findings obtained at 7 years of age showed that superior educational attainments were already apparent before the onset of myopia. Children with myopia read in their leisure time more often than normally sighted children, but despite the visual impairment, they participated in outdoor sports as often as other children.

  9. Investigating Persuasive Writing by 9-11 Year Olds

    ERIC Educational Resources Information Center

    Beard, Roger; Burrell, Andrew; Homer, Matt

    2016-01-01

    Within research into children's persuasive writing, relatively little work has been done on the writing of advertisements, how such writing develops in the primary school years and the textual features that help to secure this development. Framed within rhetoric, writing and linguistics, an exploratory study was undertaken in which a standardised…

  10. Achievement Motivation and Physical Fitness of 15-Year Old Girls

    ERIC Educational Resources Information Center

    Guszkowska, Monika; Rychta, Tadeusz

    2007-01-01

    Study aim: To determine the relations between the general and physical education-specific achievement motivation, and physical fitness of adolescent girls. Material and methods: A group of 52 girls aged 15 years were studied by applying two questionnaires: P-O scale of Widerszal-Bazyl for evaluating the general achievement motivation and Nishida's…

  11. Old Premises and Old Promises: Contemporary Critical Theory and Teaching at the Two-Year College.

    ERIC Educational Resources Information Center

    Will, Norman P.

    One composition teacher's experiences with the pluralistic student body of a two-year college led him to question the value of higher education, in particular writing and literature. Most current literature teachers were trained in the principles and methods of New Criticism, and most have found that these approaches are not adequate for their…

  12. Treatment of Cataplexy in a Three-Year-Old Using Venlafaxine

    PubMed Central

    Ratkiewicz, Michelle; Splaingard, Mark

    2013-01-01

    Narcolepsy with cataplexy is rare in children under 5 years of age. There is limited information on safe and effective treatment of cataplexy in young children. We describe successful treatment of cataplexy in a 3-year-old using venlafaxine and subsequently followed for over 2 years. Citation: Ratkiewicz M; Splaingard M. Treatment of cataplexy in a three-year-old using venlafaxine. J Clin Sleep Med 2013;9(12):1341-1342. PMID:24340297

  13. [Delirium in a 73-year-old man after many years of unwise use of betahistine].

    PubMed

    Hoenders, H J R; Wilterdink, J

    2004-11-20

    A 73-year-old man was admitted because of delirium that had already persisted for 5 days. The physical examination and extensive tests did not reveal any somatic pathology. The only drug he used was betahistine, taken for several years because of supposed Ménière's disease. After withdrawal of betahistine and treatment with haloperidol the patient recovered completely within a few days. A new delirium was induced when, after discharge from the hospital, betahistine was restarted because of dizziness. There was again a complete remission after betahistine was stopped and haloperidol was restarted. Betahistine is not known to induce delirium, but an investigation in side-effects databases did reveal several cases in which delirium might have been present, even though the term was not actually used. In this case, delirium was possibly caused by the combination of an elevated betahistine plasma level and a damaged blood-brain barrier due to cerebral infarctions, which were revealed by CT and MRI.

  14. Proceedings of the Hypertext Standardization Workshop (Gaithersburg, Maryland, January 16-18, 1990).

    ERIC Educational Resources Information Center

    Moline, Judi, Ed.; And Others

    This report constitutes the proceedings of a three day workshop on Hypertext Standardization held at the National Institute of Standards and Technology (NIST) on January 16-18, 1990. Efforts towards standardization of hypertext have already been initiated in various interested organizations. The major purpose of the workshop was to provide a forum…

  15. [The World Health Organization is 50 years old].

    PubMed

    1998-10-01

    In celebration of the World Health Organization's 50th anniversary, this article features WHO's contribution to the world by examining its current activities in the areas of health, human rights, and development. It briefly summarizes events leading to its establishment over the period from 1851 to 1948, which marks the year when WHO assumed its role as a specialized body of the United Nations. Quoting from various articles in WHO's Constitution, it illustrates the principles that prompt its actions and that have led nations to become aware of their potential goals, thus steering them toward a brighter future. A brief overview of the last 20 years ends with the introduction of WHO's new Director General, Dr. Gro Harlem Brundtland.

  16. A 10,000 YEAR OLD EXPLOSION IN DR21

    SciTech Connect

    Zapata, Luis A.; Perez-Goytia, Nadia; Rodriguez, Luis F.; Loinard, Laurent; Schmid-Burgk, Johannes; Ho, Paul T. P.; Cruz-Gonzalez, Irene

    2013-03-10

    Sensitive high angular resolution ({approx}2'') CO(2-1) line observations made with the Submillimeter Array of the flow emanating from the high-mass star-forming region DR21 located in the Cygnus X molecular cloud are presented. These new interferometric observations indicate that this well known enigmatic outflow appears to have been produced by an explosive event that took place about 10,000 years ago, and that might be related to the disintegration of a massive stellar system such as the one that occurred in Orion Becklin-Neugebauer/Kleinman-Low 500 years ago, but about 20 times more energetic. This result therefore argues in favor of the idea that the disintegration of young stellar systems perhaps is a frequent phenomenon present during the formation of massive stars. However, many more theoretical and observational studies are still needed to confirm our hypothesis.

  17. Perthes disease in a 2-year-old child

    PubMed Central

    Dhas, Daphne; Viswanath, Aparna

    2015-01-01

    Perthes disease represents a transient interruption of the blood supply to the femoral head followed by collapse and subsequent remodelling. The majority of cases present between the ages of 4 and 10 years. We report the case of a child who developed a painful right-sided limp some days after his second birthday. The limp was initially interpreted as a transient synovitis of the hip. However, when the limp persisted, further investigations revealed that he had Perthes disease. PMID:25733084

  18. 30,000-year-old wild flax fibers.

    PubMed

    Kvavadze, Eliso; Bar-Yosef, Ofer; Belfer-Cohen, Anna; Boaretto, Elisabetta; Jakeli, Nino; Matskevich, Zinovi; Meshveliani, Tengiz

    2009-09-11

    A unique finding of wild flax fibers from a series of Upper Paleolithic layers at Dzudzuana Cave, located in the foothills of the Caucasus, Georgia, indicates that prehistoric hunter-gatherers were making cords for hafting stone tools, weaving baskets, or sewing garments. Radiocarbon dates demonstrate that the cave was inhabited intermittently during several periods dated to 32 to 26 thousand years before the present (kyr B.P.), 23 to 19 kyr B.P., and 13 to 11 kyr B.P. Spun, dyed, and knotted flax fibers are common. Apparently, climatic fluctuations recorded in the cave's deposits did not affect the growth of the plants because a certain level of humidity was sustained.

  19. Sudden unexplained death among persons 1-35 years old.

    PubMed

    Morentin, Benito; Suárez-Mier, Maria Paz; Aguilera, Beatriz

    2003-08-27

    Sudden unexplained death (SUD) on children and young people is unusual, although the real magnitude is unknown. The clinical and physiopathological characteristics are poorly defined. The aim of this work is to analyse the epidemiological, clinical and pathological characteristics of SUD on children and young people. In this population observational study, all sudden non-violent deaths between 1 and 35 years occurred in Bizkaia (north Spain) from 1991 to 1998 were investigated, analysing those diagnosed as SUD. Pathological records, circumstances of death and autopsy findings were obtained. Out of 107 cases of sudden death (SD), 19 were SUD. The mortality rate of SUD was 0.43/100,000 persons per year. Five had pathological antecedents: syncopal episodes in three cases and tachycardia and ventricular extrasystoles one each. The initial symptom was sudden collapse (N=13). In four cases, a precipitating factor was identified (two physical exercise and two emotional stress). Six cases died during sleep. Minimal pathological findings in coronary arteries, myocardium or conduction system was found in nine cases. Heart weight increased (under interval of confidence of 95%) was present in 12 cases. In conclusion, the SUD is very infrequent in children and young people. However, it has great clinical significance because it affects people in good health and occurs without warning symptoms. Some of these cases can be due to cardiac arrhythmias. In deaths in bed there is a high frequency of SUD. In the future, it may be possible that abnormalities at a molecular level will be detected in some of the cases identified today as SUD.

  20. NASA's Great Observatories May Unravel 400-Year Old Supernova Mystery

    NASA Astrophysics Data System (ADS)

    2004-10-01

    Four hundred years ago, sky watchers, including the famous astronomer Johannes Kepler, best known as the discoverer of the laws of planetary motion, were startled by the sudden appearance of a "new star" in the western sky, rivaling the brilliance of the nearby planets. Kepler's Supernova Remnant Multiple Images of Kepler's Supernova Remnant Modern astronomers, using NASA's three orbiting Great Observatories, are unraveling the mysteries of the expanding remains of Kepler's supernova, the last such object seen to explode in our Milky Way galaxy. When a new star appeared Oct. 9, 1604, observers could use only their eyes to study it. The telescope would not be invented for another four years. A team of modern astronomers has the combined abilities of NASA's Great Observatories, the Spitzer Space Telescope (SST), Hubble Space Telescope (HST), and Chandra X-ray Observatory, to analyze the remains in infrared radiation, visible light, and X-rays. Ravi Sankrit and William Blair of the Johns Hopkins University in Baltimore lead the team. The combined image unveils a bubble-shaped shroud of gas and dust, 14 light-years wide and expanding at 4 million mph. Observations from each telescope highlight distinct features of the supernova, a fast-moving shell of iron-rich material, surrounded by an expanding shock wave sweeping up interstellar gas and dust. Interview with Dr. Ravi Sankrit Interview with Dr. Ravi Sankrit "Multi-wavelength studies are absolutely essential for putting together a complete picture of how supernova remnants evolve," Sankrit said. Sankrit is an associate research scientist, Center for Astrophysical Sciences at Hopkins and lead for HST astronomer observations. "For instance, the infrared data are dominated by heated interstellar dust, while optical and X-ray observations sample different temperatures of gas," Blair added. Blair is a research professor, Physics and Astronomy Department at Hopkins and lead astronomer for SST observations. "A range of

  1. HPV-16/18 detection does not affect the prognosis of head and neck squamous cell carcinoma in younger and older patients

    PubMed Central

    Marques-Silva, Luciano; Farias, Lucyana Conceição; Fraga, Carlos Alberto de Carvalho; de Oliveira, Marcos Vinícius Macedo; Cardos, Cláudio Marcelo; Fonseca-Silva, Thiago; Gomes, Carolina Cavalieri; De-Paula, Alfredo Maurício Batista; Gomez, Ricardo Santiago

    2012-01-01

    Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus on patient prognosis. A longitudinal prospective study was used adjusted for age, gender, TNM staging, smoking status and alcohol consumption. HPV was detected by PCR with consensus primers. Results showed there was no difference in the frequency of HPV-16/18 positivity when younger patients were compared to the older patients. No association was found among high-risk HPV positivity, gender, smoking habit and anatomical site. High-risk HPV was associated with advanced TNM in bivariate analyses; however, it did not impact on survival. Only TNM staging was associated with risk of mortality. Our study supports the theory that age does not affect the presence of HPV-16/18 in HNSCC and has no impact on patient prognosis. The incidence of HNSCC among patients under the age of 45 years is reportedly on the increase worldwide. The factors associated with HNSCC in younger adults are not well established. Findings of this study indicate that HPV-16/18 may not play a role in HNSCC patients under the age of 45 years. PMID:22741024

  2. Intraneural ganglion cyst: a 200-year-old mystery solved.

    PubMed

    Spinner, Robert J; Vincent, Jean-François; Wolanskyj, Alexandra P; Scheithauer, Bernd W

    2008-10-01

    We describe the first reported case of an intraneural ganglion cyst, an ulnar ("cubital") intraneural cyst, which, on literature review, dated to 1810. For over 80 years, its original brief description by Beauchêne was wrongly attributed to Duchenne, effectively making the reference and specimen inaccessible to scrutiny. Fortunately, the intact cyst had been safely housed in the Musée Dupuytren, Paris, France, thus permitting its examination. Although originally described as a "serous" cyst, our present understanding of the anatomy of the ulnar nerve and of peripheral nerve pathology allowed us to reinterpret it as a mucin-filled, elbow-level, ulnar intraneural ganglion cyst. In addition to its description as a fusiform cystic enlargement of the nerve, we documented similar enlargement of a lumen-bearing branch, the articular branch at the level of the elbow. Based on our assessment of the specimen and with a modern perspective, we concluded that the origin of the cyst was from the postero-medial aspect of the elbow joint and that its fluid content, having dissected through a capsular defect, followed the path of the articular branch into the parent ulnar nerve. The purpose of this report is to clarify historical misconceptions regarding the pathogenesis of this controversial entity.

  3. Possible shell disease in 100 million-year-old crabs.

    PubMed

    Klompmaker, Adiël A; Chistoserdov, Andrei Y; Felder, Darryl L

    2016-05-03

    Modern organisms exhibit evidence of many diseases, but recognizing such evidence in fossils remains difficult, thus hampering the study of the evolution of disease. We report on 2 molts of the goniodromitid crabs Distefania incerta and Goniodromites laevis from the mid-Cretaceous (late Albian) of Spain, with both species exhibiting damage to the dorsal carapace in otherwise well-preserved specimens. The subcircular to quadratical holes, found in <0.2% of the specimens, resemble damage caused by bacterial infections on the cuticle of modern decapods in terms of size and shape. Abiotic damage, predation, and encrustation followed by damage to the shell provide less satisfactory explanations, although these agents cannot be completely excluded from a role in shell disease etiology. We hypothesize that the observed fossil lesions are caused primarily by bacterial disease that started prior to molting, with or without other agents of initiation. If correct, this is the only known example of such bacterial infections in decapod crustaceans from the fossil record thus far, pushing back the evolutionary history of this type of shell disease by ~100 million years.

  4. Spontaneous analog number representations in 3-year-old children.

    PubMed

    Cantlon, Jessica F; Safford, Kelley E; Brannon, Elizabeth M

    2010-03-01

    When enumerating small sets of elements nonverbally, human infants often show a set-size limitation whereby they are unable to represent sets larger than three elements. This finding has been interpreted as evidence that infants spontaneously represent small numbers with an object-file system instead of an analog magnitude system (Feigenson, Dehaene & Spelke, 2004). In contrast, non-human animals and adult humans have been shown to rely on analog magnitudes for representing both small and large numbers (Brannon & Terrace, 1998; Cantlon & Brannon, 2007; Cordes, Gelman, Gallistel & Whalen, 2001). Here we demonstrate that, like adults and non-human animals, children as young as 3 years of age spontaneously employ analog magnitude representations to enumerate both small and large sets. Moreover, we show that children spontaneously attend to numerical value in lieu of cumulative surface area. These findings provide evidence of young children's greater sensitivity to number relative to other quantities and demonstrate continuity in the process they spontaneously recruit to judge small and large values.

  5. Spontaneous Analog Number Representations in 3-year-old Children

    PubMed Central

    Cantlon, Jessica F.; Safford, Kelley E.; Brannon, Elizabeth M.

    2009-01-01

    When enumerating small sets of elements nonverbally, human infants often show a set-size limitation whereby they are unable to represent sets larger than three elements. This finding has been interpreted as evidence that infants spontaneously represent small numbers with an object-file system instead of an analog magnitude system (Feigenson, Spelke, and Dehaene, 2004). In contrast, non-human animals and adult humans have been shown to rely on analog magnitudes for representing both small and large numbers (Brannon & Terrace, 1998; Cantlon & Brannon, 2007; Cordes et al., 2001). Here we demonstrate that, like adults and non-human animals, children as young as three years of age spontaneously employ analog magnitude representations to enumerate both small and large sets. Moreover, we show that children spontaneously attend to numerical value in lieu of cumulative surface area. These findings provide evidence of young children’s greater sensitivity to number relative to other quantities and demonstrate continuity in the process they spontaneously recruit to judge small and large values. PMID:20136925

  6. The phonological skills of Samoan speaking 4-year-olds.

    PubMed

    Ballard, Elaine; Farao, Sharon

    2008-01-01

    To date there has been little research on the typical developmental patterns for children speaking Samoan. The research outlined in this paper serves to fill this gap by reporting on the phonological development of Samoan speaking children growing up in the English dominant language environment of Auckland New Zealand. In this study 20 children aged between 4;0 and 4;11 were assessed using a picture naming task that probed their knowledge of the Samoan phonemic inventory. The findings presented here give an indication of what children in their fifth year have as speech sounds in their phonetic inventory and the types of errors that they may still produce. These results demonstrate the similarities and differences that Samoan phonological development shares with other languages. In particular the differences that seem "atypical" when compared with studies on English are discussed. It is tentatively concluded that these differences may well be typical for Samoan speech acquisition given language specific factors and the bilingual context in which these children are growing up.

  7. Perspectives on the ARE as it turns 25 years old

    PubMed Central

    Beisang, Daniel; Bohjanen, Paul R.

    2014-01-01

    The AU-rich element (ARE) was discovered in 1986 as a conserved mRNA sequence found in the 3′ untranslated region of the TNF-α transcript and other transcripts encoding cytokines and inflammatory mediators. Shortly thereafter, the ARE was shown to function as a regulator of mRNA degradation, and AREs were later shown to regulate other posttranscriptional mechanisms such as translation and mRNA localization. AREs coordinately regulate networks of chemokine, cytokine, and growth regulatory transcripts involved in cellular activation, proliferation, and inflammation. ARE-mediated regulation is carried out by a host of ARE-binding proteins, whose activity is regulated in a cell type and activation-dependent manner. The last 25 years of ARE research has offered insight into the mechanisms and regulation of ARE-mediated mRNA decay, and has provided a road map for the discovery of additional mRNA regulatory motifs. The future of ARE research will transition from a discovery phase to a phase focused on translating basic biological findings into novel therapeutic targets. Our understanding of ARE-mediated gene regulation and posttranscriptional control has implications for many fields of study including developmental biology, neuroscience, immunobiology, and cancer biology. PMID:22733578

  8. Mastery of Fundamental Movement Skills among 6-Year-Old Flemish Pre-School Children

    ERIC Educational Resources Information Center

    Vandaele, Bart; Cools, Wouter; de Decker, Steve; de Martelaer, Kristine

    2011-01-01

    The purpose of this study was to assess mastery of Fundamental Movement Skills (FMS) in 6- to 6.5-year-old Flemish pre-school children. The subjects were 236 6-year-old children (138 boys, 98 girls; mean age 6 years 2.4 months, SD 2.4). Children were individually assessed with the Motoriktest fur Vier- bis Sechsjahrige Kinder (MOT 4-6) in four…

  9. Gait in 5-year-old children with idiopathic clubfoot

    PubMed Central

    Lööf, Elin; Andriesse, Hanneke; André, Marie; Böhm, Stephanie; Broström, Eva W

    2016-01-01

    Background and purpose Idiopathic clubfoot can be bilateral or unilateral; however, most studies of gait have assessed clubfoot cases as one uniform group. The contralateral foot in children with unilateral clubfoot has shown deviations in pedobarographic measurements, but it is seldom included in studies of gait. We evaluated gait in children with idiopathic clubfoot, concentrating on foot involvement. Patients and methods Three-dimensional gait analyses of 59 children, mean age 5.4 years, with bilateral (n = 30) or unilateral (n = 29) idiopathic clubfoot were stratified into groups of bilateral, unilateral, or contralateral feet. Age-matched controls (n = 28) were evaluated for comparison. Gait assessment included: (1) discrete kinematic and kinetic parameters, and (2) gait deviation index for kinematics (GDI) and kinetics (GDI-k). Results No differences in gait were found between bilateral and unilateral idiopathic clubfoot, but both groups deviated when compared to controls. Compared to control feet, contralateral feet showed no deviations in discrete gait parameters, but discrepancies were evident in relation to unilateral clubfoot, causing gait asymmetries in children with unilateral involvement. However, all groups deviated significantly from control feet according to GDI and GDI-k. Interpretation Bilateral and unilateral idiopathic clubfoot cases show the same persistent deviations in gait, mainly regarding reduced plantarflexion. Nevertheless, knowledge of foot involvement is important as children with unilateral clubfoot show gait asymmetries, which might give an impression of poorer deviations. The results of GDI/GDI-k indicate global gait adaptations of the contralateral foot, so the foot should preferably not be used as a reference for gait. PMID:27331243

  10. Plagiarism in the article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini et al. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505).

    PubMed

    2015-01-01

    This retracts article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini, Amadou Kassogue, Mohammed Fadl Tazi, Anas Zaougui, Jalal Edine Elammari, Abdelhak Khallouk, Mohammed Jamal El Fassi, My Hassan Farih. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505).[This retracts the article DOI: 10.11604/pamj.2013.16.18.2505.].

  11. Doctors and baldness: a five thousand year old challenge.

    PubMed

    Campo, Daniele; D'Acunzo, Valeria

    2016-02-01

    The history of trichology follows a thread that continually intersects with that of the history of medicine in general. Even Hippocrates believed that the approach to baldness should be of a medical nature. This confrontation between doctors and hair loss, which has lasted for five thousand years, begins with the invocations of the head physicians in the Egyptian era and ends with the recent institution of postgraduate Master's degrees at Faculties of Medicine and Surgery. The biggest names in medicine concerned themselves with trichology beginning with Hippocrates, who dealt with the topic in his most famous work: the Aphorisms. Even the most celebrated doctors of the Roman era, such as Galen and Pliny the Elder, did not disdain considering hair loss, leaving important scientific contributions before passing on the baton to their distinguished colleagues of the Byzantine Empire. The narrative then flows through the most prestigious institutions of the Middle Ages, such as the Salerno School of Medicine and the Siena Accademia del Fisiocritici where, at the end of the 1600s, the distinguished anatomical describer Marcello Malpighi also taught trichology, and left his contribution to "Hair Science" with a fine description of the hair follicle in the pages of his Opera Posthuma. At the turn of the late Middle Ages and the early modern era, barbers formed the primordial nucleus of surgery and at the same time became the ones to concern themselves with hair loss. In the 1800s, several doctors published the first texts dealing with the anatomy and physiology of the hair and taking into account the principal forms of alopecia, but at the therapeutic level did not yet propose anything scientifically valid. Until a few decades ago trichology still lent itself to various commercial speculations. It was not until the twentieth century that the pathogenetic mechanisms of baldness were clarified in a scientific manner. With this knowledge, the pharmaceutical industry has been

  12. Assessing Physicians' Intentions to Talk about Sex when They Vaccinate Nine-Year-Old to 15-Year-Old Girls against HPV

    ERIC Educational Resources Information Center

    Askelson, Natoshia M.; Campo, Shelly; Smith, Sandi; Lowe, John B.; Dennis, Leslie; Andsager, Julie

    2011-01-01

    The human papillomavirus (HPV) vaccine provides physicians with an opportunity to have conversations with girls about sex and sex-related topics. Current research suggests that these conversations are not happening. This study was designed to assess whether physicians would use the HPV vaccination as an opening to communicate with nine-year-old to…

  13. Case Report: Homicide by a 10-Year-Old Girl with Autistic Disorder

    ERIC Educational Resources Information Center

    Mukaddes, Nahit Motavalli; Topcu, Zerrin

    2006-01-01

    This case study presents a 10-year-old girl with a diagnosis of Autistic Disorder, who killed her 6-month-old sister by throwing her out of a window. Her aggressive-impulsive behavior had a persistent pattern. She had a history of epilepsy, and was frequently exposed to physical abuse. She never attended a structured treatment program. Here, we…

  14. Structure Beyond the Dripline in the Boron Isotopes: 16,18,20,21B

    NASA Astrophysics Data System (ADS)

    Marqués, F. Miguel; Leblond, Sylvain; Gibelin, Julien; Orr, Nigel A.; Ogoshi, Shun; Minakata, Ryogo; Kondo, Yosuke; Nakamura, Takashi; Tanaka, Ryuki; Achouri, N. Lynda; Aumann, Thomas; Baba, Hidetada; Delaunay, Franck; Doornenbal, Pieter; Fukuda, Naoki; Hwang, Jongwong; Inabe, Naohito; Isobe, Tadaaki; Kameda, Daisuke; Kanno, Daiki; Kim, Sunji; Kobayashi, Nobuyuki; Kobayashi, Toshio; Kubo, Toshiyuki; Lee, Jenny; Motobayashi, Tohru; Murai, Daichi; Murakami, Tetsuya; Muto, Kotomi; Nakashima, Tomohiro; Nakatsuka, Noritsugu; Navin, Alahari; Nishi, Seijiro; Otsu, Hideaki; Sato, Hiromi; Satou, Yoshiteru; Shimizu, Yohei; Suzuki, Hiroshi; Takahashi, Kento; Takeda, Hiroyuki; Takeuchi, Satoshi; Togano, Yasuhiro; Tuff, Adam G.; Vandebrouck, Marine; Yoneda, Ken-ichiro

    As part of the first phase program of experiments utilizing the SAMURAI spectrometer and NEBULA neutron array, we have undertaken invariant mass spectroscopy of 16,18,20,21B using the complementary probes of neutron and proton knockout. After a brief introduction to the experimental setup and analysis techniques, the results for 16,18B are discussed and compared to earlier work, where in addition to substantially improving our knowledge of the known threshold states in both systems, evidence for new levels has been found. Finally, the first results for 20,21B are presented, and the influence of the sequential decay of 21B on the low-energy 20B spectrum discussed.

  15. Persuasion from an Eighteen-Year-Old's Perspective: Perry and Piaget.

    ERIC Educational Resources Information Center

    Dinitz, Sue; Kiedaisch, Jean

    1990-01-01

    Looks at how the theories of William Perry and Jean Piaget explain choices students made in writing persuasive essays. Examines the implications of their theories for teaching persuasion to eighteen-year olds. (SR)

  16. Treatment of an extensive unicystic ameloblastoma in a 7-year-old child: the best approach?

    PubMed

    de Paulo, L F B; Oliveira, M T F; Rodrigues, Á R; Zanetta-Barbosa, D

    2015-03-01

    Ameloblastoma is a benign, slow-growing neoplasm of the jaw that arises from odontogenic epithelium. We present the case of a 7-year-old girl with a unicystic ameloblastoma of the mandible, and describe our approach to treatment.

  17. Paroxysmal hemicrania with visual aura in a 17-year-old boy.

    PubMed

    Seidel, Stefan; Wöber, Christian

    2009-04-01

    We report the case of a 17-year-old boy presenting with a history of recurrent episodes of isolated visual aura later followed infrequently by indomethacin-responsive headache attacks resembling paroxysmal hemicrania.

  18. Basilar impression and osteogenesis imperfecta in a three-year-old girl: CT and MRI.

    PubMed

    Rush, P J; Berbrayer, D; Reilly, B J

    1989-01-01

    A 3-year-old girl with osteogenesis imperfecta developed symptomatic basilar impression. Her neurological symptoms were treated by foramen magnum decompression and laminectomy. This is an unusually young patient to have this condition.

  19. An Investigation into Understanding of Geological Time among 10- and 11-Year-Old Children.

    ERIC Educational Resources Information Center

    Trend, Roger

    1998-01-01

    Focuses on the understanding of British children (N=189) of geologic time as they participate in related activities. Indicates that 10- and 11-year-old children lack a clear chronology of geologic events. Contains 22 references. (DDR)

  20. Treatment of a Circadian Rhythm Disturbance in a 2-Year-Old Blind Child.

    ERIC Educational Resources Information Center

    Mindell, J. A.; And Others

    1996-01-01

    The use of sleep scheduling and a daytime routine for the treatment of circadian rhythm disorder was found helpful in decreasing a blind 2-year old's nighttime wake periods and daytime sleepiness. (DB)

  1. Developmental changes and the effect of self-generated feedback in metacognitive controlled spacing strategies in 7-year-olds, 10-year-olds, and adults.

    PubMed

    Tsalas, Nike; Paulus, Markus; Sodian, Beate

    2015-04-01

    The current study investigated the development of metacognitive monitoring-based control of spacing choices in children and adults. Moreover, we assessed whether metacognitive learning decisions are influenced by the effects of previous metacognitive decisions. We tested groups of 7-year-olds, 10-year-olds, and adults in a task with two learning blocks in which they needed to monitor their learning through judgments of learning (JoL) and in which they then needed to decide whether to space their study, mass it, or terminate it. Extending previous findings, our study provides the first evidence that already by 7 years of age children can make metacognitive controlled scheduling decisions. The results also revealed that adults had more clearly differentiated strategies related to their JoL. Furthermore, our study provides evidence that participants of all age groups improved their relative monitoring accuracy in the second learning block and adjusted their JoL. However, only adults changed their strategy choices.

  2. The Social Development of Two Year Old Children in Residential Nurseries.

    ERIC Educational Resources Information Center

    Tizard, Jack; Tizard, Barbara

    This study focuses upon some aspects of the social behavior of 2-year-old children being reared in long-stay residential nurseries. These children are compared with working class 2-year-old children being raised in two-parent homes in which the mother is not working full-time and there are no older siblings of preschool age. All children were…

  3. Filariasis presenting as a scrotal nodule in a 2 year old child: a case report.

    PubMed

    Yagain, Kiran; Mathew, Mary

    2011-02-01

    A two year old boy from southwestern village of India presented with a 2 cm × 1 cm size swelling in scrotum for 8 months. It was excised surgically and the histopathological examination revealed a gravid filarial worm. The occurrence of adult filarial worm in 2 year old boy signifies the endemicity and high larval load of insect vectors in western coast of south India.

  4. Cognitive function in 70-year-old men and women. A 16-year cohort difference population study.

    PubMed

    Steen, G; Berg, S; Steen, B

    1998-04-01

    Cohort differences in cognitive functioning were studied in two 70-year-old samples born 16 years apart, 1906/07 and 1922, and living in Göteborg, Sweden. Psychometric tests measuring verbal ability, inductive reasoning, spatial ability, perceptual speed, secondary memory, and primary memory were used. All tests showed significantly better results in the latter 70-year-old cohort. Longer education and better living conditions in this cohort help to explain the results. Differences in somatic health could not explain the cognitive differences in this population. If biological age is defined as inversely related to the remainder of an individual's life span, the increasing life expectancy also means that the 70-year olds in 1992 are biologically younger than their 1976/77 counterparts.

  5. Treatment of cataplexy in a three-year-old using venlafaxine.

    PubMed

    Ratkiewicz, Michelle; Splaingard, Mark

    2013-12-15

    Narcolepsy with cataplexy is rare in children under 5 years of age. There is limited information on safe and effective treatment of cataplexy in young children. We describe successful treatment of cataplexy in a 3-year-old using venlafaxine and subsequently followed for over 2 years.

  6. Opening and Closing Interactive Spaces: Shaping Four-Year-Old Children's Participation in Two English Settings

    ERIC Educational Resources Information Center

    Payler, Jane

    2007-01-01

    This paper draws on an ESRC-funded study (Payler, 2005) of the sociocultural influences on learning processes of 10 four-year-old children in their second year of the Foundation Stage in England (DfEE, 2000). The children, very close in age, were in one of two early years settings: a pre-school playgroup with a largely invisible pedagogy…

  7. Motor Competence Is Associated with Physical Fitness in Four- to Six-Year-Old Preschool Children

    ERIC Educational Resources Information Center

    Sigmundsson, Hermundur; Haga, Monika

    2016-01-01

    The health benefits of a physical active lifestyle and physical fitness from a young age are widely recognized as beneficial. This study examined the relationship between physical fitness and motor competence in children aged four- to six-years-old. A sample of 42 children (mean age 5.15 years, SD 0.56 year) participated in the study. To assess…

  8. Successful Aging in a 70-Year-Old Man with Down Syndrome: A Case Study

    ERIC Educational Resources Information Center

    Krinsky-McHale, Sharon J.; Devenny, Darlynne A.; Gu, Hong; Jenkins, Edmund C.; Kittler, Phyllis; Murty, Vundavalli V.; Schupf, Nicole; Scotto, Luigi; Tycko, Benjamin; Urv, Tiina K.; Ye, Lingling; Zigman, Warren B.; Silverman, Wayne

    2008-01-01

    The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well…

  9. [Primary pulmonary artery sarcoma in 36-year-old women: 3-years follow-up after partial resection and radiotherapy].

    PubMed

    Drożdż, Jarosław; Warchoł, Ewa; Fijuth, Jacek; Filipiak, Krzysztof; Spych, Michał; Maciejewski, Marek; Piestrzeniewicz, Katarzyna; Ludomir, Stafańczyk; Janaszek-Sitkowska, Hanna; Januszewicz, Andrzej; Zembala, Marian

    2013-01-01

    Intimal sarcoma of the heart and pulmonary artery is a very rare, malignant, primary tumour. The prognosis in patients with primary sarcoma of the pulmonary artery, including intimal sarcoma, is poor. We present the case and 3-years follow-up of 36-year-old woman who was successfully treated with surgical, partial resection of the tumour followed by radiotherapy.

  10. Plagiarism in the article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini et al. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505)

    PubMed Central

    2015-01-01

    This retracts article Emphysematous cystitis and emphysematous pyelitis: a clinically misleading association. Mustapha Ahsaini, Amadou Kassogue, Mohammed Fadl Tazi, Anas Zaougui, Jalal Edine Elammari, Abdelhak Khallouk, Mohammed Jamal El Fassi, My Hassan Farih. The Pan African Medical Journal. 2013;16:18. (doi:10.11604/pamj.2013.16.18.2505). PMID:26328003

  11. Kienbock's disease in an eleven-year-old girl. A case report.

    PubMed

    Minami, A; Itoga, H; Kobayashi, M

    1992-01-01

    Kienbock's disease occurs most frequently between 20 and 30 years of age (Gillespie, 1961). The youngest patient with Kienbock's disease in literature written in English is a 10-year-old boy (Nakamura et al., 1990). We report the case of an 11-year-old girl with Kienbock's disease whom we treated with radial shortening. Five months after surgery, radiographs showed signs of rapid disappearance of avascular necrosis of the lunate, and the patient had excellent clinical results. Two years postoperatively no recurrence of avascular necrosis of the lunate has occurred.

  12. The shadow of the future: 5-year-olds, but not 3-year-olds, adjust their sharing in anticipation of reciprocation.

    PubMed

    Sebastián-Enesco, Carla; Warneken, Felix

    2015-01-01

    Cooperation can be maintained if individuals reciprocate favors over repeated interactions. However, it is not known when during development the psychological capacities to engage in contingent reciprocation emerge. Therefore, we tested when children begin to differentiate between reciprocal and nonreciprocal interactions in their resource sharing. We compared the sharing behavior of 3- and 5-year-olds in two situations. In an experimental condition, the child and a puppet partner alternated the roles of donor and recipient. In a control condition, the puppet had no opportunity to reciprocate. Results showed that 5-year-olds, but not 3-year-olds, increased their sharing toward a potential reciprocator. In addition, we found that children's ability to delay gratification was positively related to their tendency to share in both conditions. These findings show that reciprocity in anticipation of repeated interactions emerges during middle childhood. Moreover, our results highlight the importance of the ability to delay gratification as a prerequisite for children's sharing. We discuss how children's emerging cognitive abilities enable reciprocal sharing in situations where a child must react to or anticipate a partner's behavior.

  13. 40 CFR 721.10313 - Fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...., Me esters, epoxidized. 721.10313 Section 721.10313 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10313 Fatty acids, C16-18 and C18-unsatd., Me esters... identified as fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized (PMN P-02-249; CAS No....

  14. 40 CFR 721.10313 - Fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...., Me esters, epoxidized. 721.10313 Section 721.10313 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10313 Fatty acids, C16-18 and C18-unsatd., Me esters... identified as fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized (PMN P-02-249; CAS No....

  15. 40 CFR 721.10313 - Fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...., Me esters, epoxidized. 721.10313 Section 721.10313 Protection of Environment ENVIRONMENTAL PROTECTION... New Uses for Specific Chemical Substances § 721.10313 Fatty acids, C16-18 and C18-unsatd., Me esters... identified as fatty acids, C16-18 and C18-unsatd., Me esters, epoxidized (PMN P-02-249; CAS No....

  16. Long-term persistence of systemic and mucosal immune response to HPV-16/18 AS04-adjuvanted vaccine in preteen/adolescent girls and young women.

    PubMed

    Petäjä, Tiina; Pedersen, Court; Poder, Airi; Strauss, Gitte; Catteau, Gregory; Thomas, Florence; Lehtinen, Matti; Descamps, Dominique

    2011-11-01

    Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10-25 years. Serum and cervicovaginal secretion (CVS) samples were collected at prespecified time-points during the 48-month follow-up period. Anti-HPV-16/18 antibody levels in serum and CVS were measured by enzyme-linked immunosorbent assay (ELISA). At Month 48, all subjects remained seropositive for serum anti-HPV-16 and -18 antibodies. As previously observed, anti-HPV-16 and -18 antibodies levels (ELISA Units/mL) were higher in subjects vaccinated at the age of 10-14 years (2862.2 and 940.8) compared to subjects vaccinated at the age of 15-25 years (1186.2 and 469.8). Moreover, anti-HPV-16 and -18 antibodies in CVS were still detectable for subjects aged 15-25 years (84.1% and 69.7%, respectively). There was a strong correlation between serum and CVS anti-HPV-16 and -18 antibodies levels (correlation coefficients = 0.84 and 0.90 at Month 48, respectively) supporting the hypothesis of transudation or exudation of serum immunoglobulin G antibodies through the cervical epithelium. The HPV-16/18 AS04-adjuvanted vaccine had a clinically acceptable safety profile. In conclusion, this follow-up study shows that the HPV-16/18 AS04-adjuvanted vaccine administered to preteen/adolescents girls and young women induces long-term systemic and mucosal immune response and has a clinically acceptable safety profile up to 4 years after the first vaccine dose.

  17. The First Report of Fetal Alcohol Effect in a 12 Year-Old Child in Korea

    PubMed Central

    Ahn, Dong Hyun; Lee, Young Jin; An, Ho Young; Ahn, Joon Ho

    2009-01-01

    We present the first report of fetal alcohol effect in a 12 year-old child in Korea. The mother had consumed 162 g of alcohol per week continuously during pregnancy. His first febrile seizure occurred before he was 1 year old, and became more frequent 2 years later. He started showing signs of right paraplegia when he was 3.5 years old and brain MRI revealed periventricular leucomalacia near the left ventricle. He was microcephalic and his growth was retarded. He was irritable, impatient, impulsive, and inattentive, and showed disinterest in school activities and aggressive and dangerous behavior. After the diagnosis of attention deficit/hyperactivity disorder was made, psychopharmacological treatment and family support was initiated. After 10 months, he still had intermittent ideas of reference, although the aggressive behavior, inattentiveness, and impulsivity had improved. Using this case study, we stress the importance of maternal alcohol history in patients with these characteristics. PMID:20046374

  18. Deliberate Self-Harm by under-15-Year-Olds: Characteristics, Trends and Outcome

    ERIC Educational Resources Information Center

    Hawton, Keith; Harriss, Louise

    2008-01-01

    Background: Relatively little information is available about the characteristics and long-term outcome of children and adolescents aged under 15 years who present to general hospitals because of deliberate self-harm (DSH). Method: Information was collected on 710 consecutive under-15-year-olds presenting to a general hospital in central England…

  19. Trauma Revisited: A 5-Year-Old's Journey from Experiences, to Thoughts, to Words, towards Hope

    ERIC Educational Resources Information Center

    Jackson, Emil

    2004-01-01

    In this paper, I describe the first 2 years of intensive psychotherapy of a multiply traumatized 5-year-old girl. I explore some of the ways in which violent and traumatic experiences were re-lived in the therapy and how they impacted on both patient and therapist. Within the discussion and illustrated by clinical vignettes, I consider the…

  20. [Prevalence and parasitism intensity by Pediculus humanus capitis in six to eleven-year-old schoolchildren].

    PubMed

    Catalá, Silvia; Carrizo, Lorena; Córdoba, Marina; Khairallah, Roxana; Moschella, Fabrizio; Bocca, Julio Nacif; Calvo, Ana Nieto; Torres, Judiht; Tutino, Rodrigo

    2004-01-01

    The aim of this work was to determine head lice parasitism intensity by Pediculus humanus capitis and its variation, according to both gender and age in 181 school children of a primary school. The intensity was higher among 6 to 8-year-old girls. Pediculosis intensity diminishes significantly between 9 and 11 years of age in both sexes.

  1. Does Chess Training Affect Conceptual Development of Six-Year-Old Children in Turkey?

    ERIC Educational Resources Information Center

    Sigirtmac, Ayperi Dikici

    2012-01-01

    Many studies propose that chess is a game requiring cognitive skills and has positive effects on mental development. In recent years, chess training has also been emphasised as important during the early childhood period. However, no studies have been done with six-year-old children. The purpose of this study was to investigate whether or not…

  2. Pharmacotherapy of Aggression in a 9-Year-Old with ADHD

    ERIC Educational Resources Information Center

    Findling, Robert L.; Newcorn, Jeffrey H.; Malone, Richard P.; Waheed, Ayesha; Prince, Jefferson B.; Kratochvil, Christopher J.

    2007-01-01

    A 9-year-old boy presents for assessment and treatment of his reactive, impulsive aggressive behavior that has been present for approximately 2 years. Six months ago, his pediatrician started treatment with OROS methylphenidate (MPH), which was titrated to 36 mg/day. There was moderate improvement in symptoms of attention-deficit/hyperactivity…

  3. Effects of Two Modes of Exercise Training on Physical Fitness of 10 Year-Old Children

    ERIC Educational Resources Information Center

    Ribeiro, Ligia G. dos Santos Chaves; Portal, Maria de Nazare Dias; da Silva, Joao Bittencourt; Saraiva, Alan; da Cruz Monte, Gerson, Jr.; Dantas, Estelio H. M.

    2010-01-01

    Study aim: To compare two exercise training modes on the physical fitness of 10 year-old children. Material and methods: A sample of 60 schoolboys aged 10 years were randomly divided into 3 groups: Traditional (TG), trained according to the Brazilian national curricular parameters, Maturational (MG), in which the degree of difficulty of the…

  4. Taxometric Analyses of Specific Language Impairment in 6-Year-Old Children

    ERIC Educational Resources Information Center

    Dollaghan, Christine A.

    2011-01-01

    Purpose: To determine whether language scores at age 6 years suggest that specific language impairments (SLIs) distribute in a categorical or in a dimensional fashion. Method: A taxometric analysis of language scores from 601 six-year-old children who were free of neonatal risk factors was performed. From among 4 candidate indicators of SLI, 2…

  5. Bordetella holmesii meningitis in a 12-year-old anorectic girl.

    PubMed

    Van Balen, Tessa; Nieman, An-Emmie; Hermans, Mirjam H A; Schneeberger, Peter M; de Vries, Esther

    2012-04-01

    We describe a 12-year-old anorectic girl with Bordetella holmesii meningitis, the techniques used for its identification, and minimum inhibitory concentrations of antibiotics for 7 B. Holmesii strains collected in the Netherlands during the past 12 years. B. holmesii meningitis has not been previously reported.

  6. [Secondary retroperitoneal fibrosis in a 39-year-old man after rectal cancer].

    PubMed

    Jarosch, A; Tiller, M; Rohrbach, H; Leimbach, T; Schepp, W

    2016-05-01

    A 39-year-old man had been treated for rectal cancer 6 years ago by lower anterior resection of the rectum and perioperative radiochemotherapy. Since then follow-up had been unremarkable but now the patient presented with unspecific lower abdominal pain. The cause of the pain was identified as paraneoplastic retroperitoneal fibrosis secondary to metachronous pulmonary metastases of the rectal cancer.

  7. The Prevention of Depression in 8- to 9-Year-Old Children: A Pilot Study

    ERIC Educational Resources Information Center

    Rooney, Rosanna; Roberts, Clare; Kane, Robert; Pike, Lisbeth; Winsor, Amber; White, Julia; Brown, Annette

    2006-01-01

    The outcomes of a new universal program aimed at preventing depressive symptoms and disorders in 8- to 9-year-old children are presented. The Positive Thinking Program is a mental health promotion program based on cognitive and behavioural strategies. It is designed to meet the developmental needs of children in the middle primary school Years 4…

  8. Eating With Your Heart In Mind: 7 to 10 Year Olds.

    ERIC Educational Resources Information Center

    National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD.

    The purpose of this brightly illustrated guide is to teach 7-10 year old children that all healthy Americans, 2 years of age or older, should eat in a way that is low in saturated fat and cholesterol so as to help reduce the risk of heart disease. The theme reflected throughout the manual is that changes in eating patterns help lower blood…

  9. Hearty Habits. Don't Eat Your Heart Out. 15-18 Year Olds.

    ERIC Educational Resources Information Center

    National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD.

    The purpose of this illustrated guide is to teach 15-18 year old students that all healthy Americans, 2 years of age or older, should eat in a way that is low in saturated fat and cholesterol to help reduce the risk of heart disease. The theme reflected throughout the manual is that changes in eating patterns help lower blood cholesterol levels…

  10. Profiles of School Readiness among Four-Year-Old Head Start Children

    ERIC Educational Resources Information Center

    Halle, Tamara G.; Hair, Elizabeth C.; Wandner, Laura D.; Chien, Nina C.

    2012-01-01

    This study uses the Family and Child Experiences Survey (FACES) data from 1997 to investigate the degree to which child, family, classroom, teacher, and Head Start program characteristics are related to children's school readiness and continued development over the four-year-old Head Start year. Latent class analyses were used to examine the…

  11. Clostridium perfringens Bacteremia in an 85-Year-Old Diabetic Man.

    PubMed

    Mirrakhimov, Aibek E; Chandra, Gopika; Voore, Prakruthi; Khan, Maliha; Halytskyy, Oleksandr; Elhassan, Ahmed; Ali, Alaa M

    2014-01-01

    Emphysematous cholecystitis is an uncommon and dangerous complication of acute cholecystitis. Common risk factors for this disease include male gender, old age, presence of diabetes mellitus and cholelithiasis. The disease is best treated with emergent surgery and parenteral antibiotics. We present the case of an 85-year-old nursing home resident who presented to our institution with a 3-day history of gradually worsening abdominal discomfort.

  12. Visual access trumps gender in 3- and 4-year-old children's endorsement of testimony.

    PubMed

    Terrier, Nathalie; Bernard, Stéphane; Mercier, Hugo; Clément, Fabrice

    2016-06-01

    Several studies have investigated how preschoolers weigh social cues against epistemic cues when taking testimony into account. For instance, one study showed that 4- and 5-year-olds preferred to endorse the testimony of an informant who had the same gender as the children; by contrast, when the gender cue conflicted with an epistemic cue--past reliability--the latter trumped the former. None of the previous studies, however, has shown that 3-year-olds can prioritize an epistemic cue over a social cue. In Experiment 1, we offer the first demonstration that 3-year-olds favor testimony from a same-gender informant in the absence of other cues. In Experiments 2 and 3, an epistemic cue-visual access--was introduced. In those experiments, 3- and 4-year-olds endorsed the testimony of the informant with visual access regardless of whether it was a same-gender informant (Experiment 3) or a different-gender informant (Experiment 2). These results demonstrate that 3-year-olds are able to give more weight to an epistemic cue than to a social cue when evaluating testimony.

  13. Mental Health Service Use among 18-Year-Old Adolescent Boys: A Prospective 10-Year Follow-Up Study.

    ERIC Educational Resources Information Center

    Sourander, Andre; Multimaki, Petteri; Santalahti, Paivi; Parkkola, Kai; Haavisto, Antti; Helenius, Hans; Nikolakaros, Georgios; Piha, Jorma; Tamminen, Tuula; Moilanen, Irma; Kumpulainen, Kirsti; Aronen, Eeva T.; Linna, Sirkka-Liisa; Puura, Kaija; Almqvist, Fredrik

    2004-01-01

    Objective: To study prevalence and factors associated with mental health service use among 18-year-old adolescent boys. Method: Predictors at age 8 and factors at age 18 associated with mental health service use during the preceding 12 months were studied in a general population sample of 2,316 Finnish boys born in 1981 attending military call-up…

  14. Resource allocation to kin, friends, and strangers by 3- to 6-year-old children.

    PubMed

    Lu, Hui Jing; Chang, Lei

    2016-10-01

    Kin altruism has been widely observed across species, including humans. However, few studies have discussed the development of kin altruism or its relationship with theory of mind. In this study, 3- to 6-year-old children allocated resources between themselves and kin, a friend, or a stranger in three allocation tasks where the allocation either incurred a cost, incurred no cost, or conferred a disadvantage. The results showed that, compared with 3- and 4-year-olds, 5- and 6-year-olds acted more altruistically toward kin and that kin altruism was uncorrelated with theory of mind. These findings suggest that, within the context of resource allocation, kin altruism emerges toward the end of early childhood and probably differs from other prosocial behavior that relies solely on the understanding of others' perspectives.

  15. Effects of a Full-Day Preschool Program on 4-Year-Old Children

    ERIC Educational Resources Information Center

    Herry, Yves; Maltais, Claire; Thompson, Katherine

    2007-01-01

    This study explored the effects of a full-day preschool program on 4-year-old children. The study compared the development of a group of children (N = 403) who attended the preschool program on a half-day basis during the 1999-2000 school year (the last year the half-day program was in place) with the development of a group of children (N = 418)…

  16. Profiles of Social-Emotional Readiness for 4-Year-Old Kindergarten

    PubMed Central

    Miller, Michele M.; Goldsmith, H. Hill

    2017-01-01

    Children who are viewed as ready for kindergarten and/or first grade typically exhibit high attention, approach, and adaptability coupled with low activity and reactivity. These characteristics tend to be especially valued by teachers and describe a child who is “teachable,” or school ready. Since many children enter formal schooling earlier by attending pre-K for 4-year olds, often called 4-year-old kindergarten, there is a need to examine school readiness earlier than kindergarten, which may look very different developmentally. If we expect children to enter formal schooling at age 4, then it should be clear what we expect of them in order to succeed. We explored which temperament, behavior, and cognitive items teachers of 4-year-old kindergarten (N = 29) rated as highly characteristic versus uncharacteristic of ready 4-year-olds. This teacher-generated data identified five clusters of children who were deemed ready for 4-year-old kindergarten. Teachers noted high cognitive skills and following directions as salient in many of the clusters, which aligns with the readiness expectations for kindergarten and first grade. However, items that distinguished the five clusters from one another referenced differences in activity level, sociability, shyness, enthusiasm, and patience that were not expected based on the previous literature with slightly older children. Given that some of the children teachers identified as especially ready for 4-year-old kindergarten did not fit this static model of a “teachable” child, a single profile of school readiness at an early age may be inappropriate. PMID:28197124

  17. Profiles of Social-Emotional Readiness for 4-Year-Old Kindergarten.

    PubMed

    Miller, Michele M; Goldsmith, H Hill

    2017-01-01

    Children who are viewed as ready for kindergarten and/or first grade typically exhibit high attention, approach, and adaptability coupled with low activity and reactivity. These characteristics tend to be especially valued by teachers and describe a child who is "teachable," or school ready. Since many children enter formal schooling earlier by attending pre-K for 4-year olds, often called 4-year-old kindergarten, there is a need to examine school readiness earlier than kindergarten, which may look very different developmentally. If we expect children to enter formal schooling at age 4, then it should be clear what we expect of them in order to succeed. We explored which temperament, behavior, and cognitive items teachers of 4-year-old kindergarten (N = 29) rated as highly characteristic versus uncharacteristic of ready 4-year-olds. This teacher-generated data identified five clusters of children who were deemed ready for 4-year-old kindergarten. Teachers noted high cognitive skills and following directions as salient in many of the clusters, which aligns with the readiness expectations for kindergarten and first grade. However, items that distinguished the five clusters from one another referenced differences in activity level, sociability, shyness, enthusiasm, and patience that were not expected based on the previous literature with slightly older children. Given that some of the children teachers identified as especially ready for 4-year-old kindergarten did not fit this static model of a "teachable" child, a single profile of school readiness at an early age may be inappropriate.

  18. Relationship between general and specific coordination in 8- to 17-year-old male basketball players.

    PubMed

    Kamandulis, Sigitas; Venckūnas, Tomas; Masiulis, Nerijus; Matulaitis, Kestutis; Balciūnas, Mindaugas; Peters, Derek; Skurvydas, Albertas

    2013-12-01

    The purpose of the present study was to investigate the relationships between general coordination, sport-specific coordination, and sport-specific fitness of 8- to 17-year-old male basketball players. 312 males with training experience ranging from one year in the 8-year-old cohort up to 10 years for the 17-year-olds performed basketball-specific fitness (20 m sprint, Illinois, countermovement jump), general coordination (20 m run with three obstacles), semi-basketball-specific coordination (20 m sprint dribbling two balls, countermovement jump with arm swing) and basketball-specific coordination (Illinois ball dribbling) tests. There were moderate to large correlations between the results of both general and basketball-specific coordination with the results of most basketball-specific coordination tests in all age groups. Correlations between general and basketball-specific coordination were large in four age groups (11-14 yr., r = .52 to r = .76), moderate in five groups (8-10, 15 & 16 yr., r = .37 to r = .46), while not significant in the 17-year-olds. These results suggest that the importance of general coordination for sport-specific skills improvements during a sports-specific skill acquisition phase, remains high at the skill refinement phase, and decreases when sport-specific skills have been mastered to near-perfection.

  19. Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: a partially-blind randomised placebo-controlled study.

    PubMed

    Denny, Lynette; Hendricks, Bronwyn; Gordon, Chivaugn; Thomas, Florence; Hezareh, Marjan; Dobbelaere, Kurt; Durand, Christelle; Hervé, Caroline; Descamps, Dominique

    2013-11-19

    In developing countries, risk of human papillomavirus (HPV) infection may be increased by the high prevalence of human immunodeficiency virus (HIV) infection. We evaluated the safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-infected women in South Africa. Asymptomatic HIV-positive women aged 18-25 years (N=120) were stratified by CD4⁺ T-cell count and randomised (1:1) to receive HPV-16/18 vaccine (Cervarix®; GlaxoSmithKline Vaccines) or placebo (Al[OH]3) at 0, 1 and 6 months (double-blind). HIV-negative women (N=30) received HPV-16/18 vaccine (open label). Anti-HPV-16/18 antibody and CD4⁺ T-cell responses, CD4⁺ T-cell count, HIV viral load, HIV clinical stage and safety were evaluated for 12 months. The safety and reactogenicity profile of the HPV-16/18 vaccine was comparable in HIV-positive and HIV-negative women. Irrespective of baseline HPV status, all HIV-positive and HIV-negative women who received the HPV-16/18 vaccine were seropositive for both HPV-16 and HPV-18 after the second vaccine dose (month 2) and remained seropositive for both antigens at month 12. Anti-HPV-16/18 antibody titres at month 12 remained substantially above levels associated with natural infection. The HPV-16/18 vaccine induced sustained anti-HPV-16/18 CD4⁺ T-cell responses in both HIV-positive and HIV-negative women. No impact of baseline CD4⁺ T-cell count or HIV viral load was observed on the magnitude of the immune response in HIV-positive women. In HIV-positive women, CD4⁺ T-cell count, HIV viral load and HIV clinical stage were unaffected by HPV-16/18 vaccine administration. In conclusion, the HPV-16/18 AS04-adjuvanted vaccine appears immunogenic and well-tolerated in women with HIV infection. Study ID: 107863/NCT00586339.

  20. Occult fracture of the lesser tuberosity in a 9-year-old female swimmer

    PubMed Central

    Aagaard, KE; Lunsjö, K

    2017-01-01

    The adolescent avulsion of the lesser tuberosity of the humerus has historically been considered as very rare. The youngest patient reported in the literature is 11 years old. We report a case of a 9-year-old girl who suffered a subscapularis tendon tear with an occult avulsion of the lesser tuberosity. Late repair restored function. Despite that late repair in this present case resulted in excellent outcome, we strongly recommend the additional axillary lateral view of the plain radiographs, as well as proper physical examination to facilitate early diagnosis. PMID:28122897

  1. Retraction of a longevity record for a 36-year-old herring gull

    USGS Publications Warehouse

    Jonkel, G.M.; Pettingill, O.S.

    1974-01-01

    Full text: The longevity record for a 36-year-old Herring Gull, Larus argentatus (Pettingill 1967, Auk 84: 123), is erroneous. Herring Gull with band number A-676871, the basis of the record, was found dead on 20 June 1966 on the shore of Little Traverse Bay near Petoskey, Michigan, and reported to the Bird Banding Laboratory. The laboratory then mistakenly advised Pettingill that this gull was banded by him on 29 June 1930 on coastal Maine. He actually banded Herring Gull number A-676871 as a young bird on one of the Beaver Islands in Lake Michigan on 8 July 1948. The gull was thus 18 instead of 36 years old.

  2. A Case of Premature Ovarian Failure in a 33-Year-Old Woman

    PubMed Central

    Colao, Emma; Granata, Teresa; Vismara, Marco F. M.; Bombardiere, Francesco; Nocera, Donatella; Luciano, Elisa; Perrotti, Nicola; Malatesta, Paola

    2013-01-01

    Objective. To assess aetiology of a POF in a 33-year-old woman and, if possible, plan a cure. Design. Case report. Setting. medical genetics diagnostic unit in a university hospital. Patient. A 33-year-old woman with premature ovarian failure (POF). Intervention(s). Genetic counseling, karyotyping, FISH study. Result(s). Turner-like diagnosis. Conclusion(s). Most cases of POF remain idiopathic. Turner syndrome can occur in very different phenotypes; cytogenetic and molecular profiling can provide a definitive diagnosis in cases with nonclassical phenotype. PMID:23509644

  3. A case of premature ovarian failure in a 33-year-old woman.

    PubMed

    Colao, Emma; Granata, Teresa; Vismara, Marco F M; Bombardiere, Francesco; Nocera, Donatella; Luciano, Elisa; Perrotti, Nicola; Malatesta, Paola

    2013-01-01

    Objective. To assess aetiology of a POF in a 33-year-old woman and, if possible, plan a cure. Design. Case report. Setting. medical genetics diagnostic unit in a university hospital. Patient. A 33-year-old woman with premature ovarian failure (POF). Intervention(s). Genetic counseling, karyotyping, FISH study. Result(s). Turner-like diagnosis. Conclusion(s). Most cases of POF remain idiopathic. Turner syndrome can occur in very different phenotypes; cytogenetic and molecular profiling can provide a definitive diagnosis in cases with nonclassical phenotype.

  4. Discoidal impressions and trace-like fossils more than 1200 million years old.

    PubMed

    Rasmussen, Birger; Bengtson, Stefan; Fletcher, Ian R; McNaughton, Neal J

    2002-05-10

    The Stirling Range Formation of southwestern Australia contains discoidal impressions and trace-like fossils in tidal sandstones. The various disks have previously been linked to the Ediacaran biota, younger than 600 million years old. From this unit, we report U-Th-Pb geochronology of detrital zircon and monazite, as well as low-grade metamorphic monazite, constraining the depositional age to between 2016 +/- 6 and 1215 +/- 20 million years old. Although nonbiological origins for the discoidal impressions cannot be completely discounted, the structures resembling trace fossils clearly have a biological origin and suggest the presence of vermiform, mucus-producing, motile organisms.

  5. Infantile fibrosarcoma of ethmoid sinus, misdiagnosed as an adenoid in a 5-year-old child

    PubMed Central

    Geramizadeh, Bita; Khademi, Bijan; Karimi, Mehran; Shekarkhar, Golsa

    2015-01-01

    Infantile fibrosarcoma of head and neck is rare and the presence of this tumor in ethmoid sinus is even more uncommon. To the best of our knowledge, <5 cases have been reported in the last 20 years in the English literature, so far, only one of which has been infantile type in a 15 months old girl. In this case report, we will explain our experience with a rare case of infantile fibrosarcoma originating from ethmoid sinus in a 5-year-old boy who presented with dyspnea and epistaxis. After biopsy, it was diagnosed as fibrosarcoma of sinus origin. PMID:26604519

  6. Well-being among 50-year-old people. The population study "50-year-old people in Kungsör".

    PubMed

    Thorell, B; Svärdsudd, K

    1990-09-01

    Self-assessed well-being has been shown to be related to earlier medical events and to be a predictor of mortality. 50-year-old men and women (n = 314) in Kungsör were invited to an examination for traditional risk factors for cardiovascular diseases and different aspects of self-assessed well-being. The differences between men and women concerning their well-being could not explain the differences in the expected mortality between the sexes. A well-developed social network and physical exercise were the most positive determinants of well-being, while drug intake, angina pectoris, and smoking were the most negative.

  7. VII. NIH Toolbox Cognition Battery (CB): factor structure for 3 to 15 year olds.

    PubMed

    Mungas, Dan; Widaman, Keith; Zelazo, Philip David; Tulsky, David; Heaton, Robert K; Slotkin, Jerry; Blitz, David L; Gershon, Richard C

    2013-08-01

    Confirmatory factor analysis was used the evaluate the dimensional structure underlying the NIH Toolbox Cognition Battery (CB) and the measures chosen to serve as concurrent validity criteria for the NIH Toolbox CB. These results were used to evaluate the convergent and discriminant validity of the CB in children ranging from 3 to 15 years of age. Results were evaluated separately for a 3- to 6-year-old group and a 8- to 15-year-old group because different validation measures were used in these age groups. Three distinct dimensions were found for the 3- to 6-year-old group: Vocabulary, Reading, and Fluid Abilities. Five dimensions were found for 8-15 year olds: Vocabulary, Reading, Episodic Memory, Working Memory, and Executive Function/Processing Speed. CB measures and their validation analogues consistently defined common factors in a pattern that broadly supported the convergent and discriminant validity of the CB, but results showed higher intercorrelation and less differentiation of cognitive dimensions in younger than in older children and in older children compared with adults. Age was strongly related to the cognitive dimensions underlying test performance in both groups of children and results are consistent with broader literature showing increasing differentiation of cognitive abilities associated with the rapid brain development that occurs from early childhood into adulthood.

  8. Even an old technique is suitable in the molecular world of science: the everted sac preparation turns 60 years old.

    PubMed

    Hamilton, Kirk L

    2014-04-15

    An old proverb states "necessity is the mother of invention." This certainly holds true in science as one pursues research questions. Experimental techniques have evolved as scientists have asked more specific research questions. Indeed, techniques such as the Ussing chamber, the perfused renal tubule preparation, patch-clamp, polymerase chain reaction, and site-directed mutagenesis have been developed over the past 60 years. However, sometimes, simple techniques may be useful and still very informative, and this certainly applies to intestinal physiology. Indeed, Gerald Wiseman and Thomas Hastings Wilson described the intestinal everted sac preparation some 60 years ago. Since then, this technique has been used for numerous research purposes including determining ion, amino acid, water and solute transport across the intestinal epithelium; and drug metabolism, absorption, and interactions in pharmaceutical/pharmacological research and even in education. This article provides a historical review of the development of the in vitro intestinal preparation that led to the everted sac preparation and its use in science.

  9. Stereotype or grammar? The representation of gender when two-year-old and three-year-old French-speaking toddlers listen to role nouns.

    PubMed

    Lévy, Arik; Gygax, Pascal; Gabriel, Ute; Zesiger, Pascal

    2016-11-01

    Using a preferential looking paradigm, the current study examined the role that grammatical gender plays when preschool French-speaking toddlers process role nouns in the masculine form (e.g., chanteurs masculine 'singers'). While being auditorily prompted with "Look at the 'a role noun'!", two- and three-year-olds were presented with two pictures of two characters ('boy-boy' versus 'girl-boy') with attributes of the given role noun (e.g., singers with microphone and music notes). All role nouns were presented in the masculine plural form, which, despite its use to refer to mixed-gender groups, can be interpreted as referring to men. We expected toddlers to be biased by stereotypes, yet when non-stereotypical role nouns were presented, toddlers were not influenced by grammatical gender, but by their own sex (even more so for three-year-old toddlers). The absence of sensitivity to grammatical cues for either age group is discussed in terms of the developmental awareness of grammatical gender.

  10. Paternal Psychosocial Characteristics and Corporal Punishment of Their 3-Year-Old Children

    ERIC Educational Resources Information Center

    Lee, Shawna J.; Perron, Brian E.; Taylor, Catherine A.; Guterman, Neil B.

    2011-01-01

    This study uses data from 2,309 biological fathers who participated in the Fragile Families and Child Well-Being Study (FFCWS) to examine associations between psychosocial characteristics and levels of corporal punishment (CP) toward their 3-year-old children over the past month. Results indicate that 61% of the fathers reported no CP over the…

  11. Getting an Early Start: Communication about Sexuality among Mothers and Children 6-10 Years Old

    ERIC Educational Resources Information Center

    Pluhar, Erika; Jennings, Tanya; DiIorio, Colleen

    2006-01-01

    Little information exists on communication about sexuality between parents and preadolescent children. This study collected qualitative data on family sexuality communication from 3 focus groups conducted with African American mothers of 6-10 year old children. Two broad themes emerged from the data: "Beyond the Birds and the Bees" and "Let's Talk…

  12. Herpes zoster in a 2-year-old vaccinated against varicella.

    PubMed

    Ulman, Catherine A; Trevino, Julian J; Gandhi, Rishi K

    2014-01-15

    Herpes zoster is uncommon in the pediatric population. We report a case of herpes zoster in a 2-year-old boy who received the live attenuated varicella zoster virus vaccination at his 12-month pediatric visit. The child was treated with acyclovir and recovered without complications.

  13. Learning Benefits of Self-Controlled Knowledge of Results in 10-Year-Old Children

    ERIC Educational Resources Information Center

    Chiviacowsky, Suzete; Wulf, Gabriele; Laroque de Medeiros, Franklin; Kaefer, Angelica; Tani, Go

    2008-01-01

    The purpose of the present study was to examine whether the learning benefits of self-controlled knowledge of results (KR) would generalize to children. Specifically, the authors chose 10-year-old children representative of late childhood. The authors used a task that required the children to toss beanbags at a target. One group received KR…

  14. Self-Controlled Feedback in 10-Year-Old Children: Higher Feedback Frequencies Enhance Learning

    ERIC Educational Resources Information Center

    Chiviacowsky, Suzete; Wulf, Gabriele; de Medeiros, Franklin Laroque; Kaefer, Angelica; Wally, Raquel

    2008-01-01

    The purpose of the present study was to examine whether learning in 10-year-old children--that is, the age group for which the Chiviacowsky et al. (2006) study found benefits of self-controlled knowledge of results (KR)--would differ depending on the frequency of feedback they chose. The authors surmised that a relatively high feedback frequency…

  15. Enhancing the Executive Functions of 3-Year-Olds in the Dimensional Change Card Sort Task

    ERIC Educational Resources Information Center

    Perone, Sammy; Molitor, Stephen J.; Buss, Aaron T.; Spencer, John P.; Samuelson, Larissa K.

    2015-01-01

    Executive functions enable flexible thinking, something young children are notoriously bad at. For instance, in the dimensional change card sort (DCCS) task, 3-year-olds can sort cards by one dimension (shape), but continue to sort by this dimension when asked to switch (to color). This study tests a prediction of a dynamic neural field model that…

  16. Acquired capillary hemangioma of the eyelid in a 49-year-old woman from Turkey

    PubMed Central

    Kıvanç, Sertaç Argun; Olcaysu, Osman Okan; Gelincik, Ibrahim

    2014-01-01

    A 49-year-old woman developed a dark brown nodular mass in the lower eyelid. The lesion had grown fast for 2 months and then had remained stable in size. Excisional biopsy was performed. Histopathological examination of an excisional biopsy specimen pointed to proliferative vessels lined by increased endothelial cells without nuclear atypism. The nodular mass evaluated as a capillary hemangioma. PMID:25370407

  17. Understanding Bullying: Using Role-Play with 12-Year-Old Boys in Cyprus

    ERIC Educational Resources Information Center

    Kaloyirou, Chrystalla; Lindsay, Geoff

    2014-01-01

    This study examines the use of role-play in order to investigate bullies' intentions, feelings and perceptions through identification and projection. The study was conducted with nine 12-year-old boys that presented high levels of bullying behaviour, according to their teachers and peers, from three state primary schools in Nicosia, Cyprus, with…

  18. Structural Priming as Learning: Evidence from Mandarin-Learning 5-Year-Olds

    ERIC Educational Resources Information Center

    Hsu, Dong-Bo

    2014-01-01

    Three experiments on structural priming in Mandarin-speaking 5-year-olds were conducted to test the priming as implicit learning hypothesis. It describes a learning mechanism that acts on a shared abstract syntactic representation in response to linguistic input using an equi-biased Mandarin SVO-"ba" alternation. The first two…

  19. Duration, Distance, and Speed Judgments of Two Moving Objects by 4- to 11-Year-Olds.

    ERIC Educational Resources Information Center

    Matsuda, Fumiko

    1996-01-01

    Four- to 11-year-olds made duration, distance, and speed judgments on Piagetian tasks where cars ran on parallel tracks. Among younger children, duration and distance judgments had approximately the same difficulty. Among older children, distance judgments were easier than duration judgments, and symmetry of effects of temporal and spatial…

  20. Abstract Sentence Representations in 3-Year-Olds: Evidence from Language Production and Comprehension

    ERIC Educational Resources Information Center

    Bencini, Giulia M. L.; Valiana, Virginia V.

    2008-01-01

    We use syntactic priming to test the abstractness of the sentence representations of young 3-year-olds (35-42 months). In describing pictures with inanimate participants, 18 children primed with passives produced more passives (11 with a strict scoring scheme, 16 with lax scoring) than did 18 children primed with actives (2 on either scheme) or 12…

  1. Directly Observed Physical Activity among 3-Year-Olds in Finnish Childcare

    ERIC Educational Resources Information Center

    Soini, Anne; Villberg, Jari; Sääkslahti, Arja; Gubbels, Jessica; Mehtälä, Anette; Kettunen, Tarja; Poskiparta, Marita

    2014-01-01

    The main purpose of the study was to determine 3-year-olds' physical activity levels and how these vary across season, gender, time of day, location, and the physical and social environment in childcare settings in Finland. A modified version of the Observational System for Recording Physical Activity in Children-Preschool (OSRAC-P) was used to…

  2. Exploring Expressive Vocabulary Variability in Two-Year-Olds: The Role of Working Memory

    ERIC Educational Resources Information Center

    Newbury, Jayne; Klee, Thomas; Stokes, Stephanie F.; Moran, Catherine

    2015-01-01

    Purpose: This study explored whether measures of working memory ability contribute to the wide variation in 2-year-olds' expressive vocabulary skills. Method: Seventy-nine children (aged 24-30 months) were assessed by using standardized tests of vocabulary and visual cognition, a processing speed measure, and behavioral measures of verbal working…

  3. Your Choice at Fourteen Plus. A New Guide for the Fourteen Year-Old.

    ERIC Educational Resources Information Center

    Matthew, Veronica; Smith, Michael

    Part of The Careers Research and Advisory Centre Choice Series, this book is written for fourteen year-old or fourteen plus students in England who, for the first time, have a choice in the selection of their school subjects. It covers topics such as decision-making, maintaining a well-balanced educational schedule, and preparing for examinations…

  4. Limitations in 4-Year-Old Children's Sensitivity to the Spacing among Facial Features

    ERIC Educational Resources Information Center

    Mondloch, Catherine J.; Thomson, Kendra

    2008-01-01

    Four-year-olds' sensitivity to differences among faces in the spacing of features was tested under 4 task conditions: judging distinctiveness when the external contour was visible and when it was occluded, simultaneous match-to-sample, and recognizing the face of a friend. In each task, the foil differed only in the spacing of features, and…

  5. Internet Gambling and Problem Gambling among 13 to 18 Year Old Adolescents in Iceland

    ERIC Educational Resources Information Center

    Olason, Daniel Thor; Kristjansdottir, Elsa; Einarsdottir, Hafdis; Haraldsson, Haukur; Bjarnason, Geir; Derevensky, Jeffrey L.

    2011-01-01

    This study reports findings on Internet gambling and problem gambling among Icelandic youth. Participants were 1.537 13-18 year-old students, 786 boys and 747 girls. Results revealed that 56.6% had gambled at least once in the past 12 months and 24.3% on the Internet. Gender and developmental differences were found for Internet gambling, as boys…

  6. Secondary mania due to AIDS and cryptococcal meningitis in a 78-year-old patient.

    PubMed

    Chou, Po-Han; Ouyang, Wen-Chen; Lan, Tsuo-Hung; Chan, Chin-Hong

    2016-03-01

    We report a 78-year-old man without past psychiatric history who experienced his first manic episode successfully treated with quetiapine and lorazepam, but was ultimately found to have AIDS and Cryptococcus neoformans meningitis. Our presented case highlights the importance of comprehensive differential diagnoses to rule out secondary causes of psychiatric symptoms presenting for the first time in elderly patients.

  7. Acquiring Proper Names for Familiar and Unfamiliar Animate Objects: Evidence from Two-Year-Olds.

    ERIC Educational Resources Information Center

    Hall, D. Geoffrey

    Two studies addressed the relative strengths of object kind bias and syntactic knowledge in 2-year-olds' inductions of word meaning. The study looked at children's interpretations of novel proper names for familiar and unfamiliar objects. In each study, 10 children were assigned to each of 2 conditions (familiar and unfamiliar) and shown 2 cats…

  8. Career Development Needs of Thirteen-Year Olds: How to Improve Career Development Programs.

    ERIC Educational Resources Information Center

    Aubrey, Roger F.

    Suggesting implications for career education program development and revision, this document is one in a series of five publications reporting results of a career development needs study of four different age levels. In this document, the assessment of career development needs of thirteen-year-olds is presented in three major sections. Section 1…

  9. Career Development Needs of Seventeen Year Olds: How to Improve Career Development Programs.

    ERIC Educational Resources Information Center

    Mitchell, Anita M.

    Suggesting implications for career education program development and revision, this document is one in a series of five publications reporting results of a career development needs study of four different age levels. In this document, the assessment of career development needs of seventeen-year-olds is presented in three major sections. Section 1…

  10. Career Development Needs of Nine-Year Olds: How to Improve Career Development Programs.

    ERIC Educational Resources Information Center

    Miller, Juliet V.

    Suggesting implications for career education program development and revision, this document is one in a series of five publications reporting results of a career development needs study of four different age levels. In this document, the assessment of career development needs of nine-year olds is presented in three major sections. Section 1…

  11. Sporotrichosis on the face of a 7-year-old boy following a bicycle accident.

    PubMed

    Williams, Blake A; Jennings, Thomas A; Rushing, Erica C; Wirges, Marla; Russell, Brian E

    2013-01-01

    A 7-year-old boy presented with an annular verrucous plaque on the chin of 5 weeks duration. The lesion occurred after a bicycle accident and was unresponsive to antibiotics. Fungal culture grew Sporothrix schenckii. Sporotrichosis should be considered and fungal culture obtained whenever a nodule or plaque fails to respond to initial treatment.

  12. Earth Science. Developing an Early Interest in Science: A Preschool Science Curriculum. (3-Year-Olds).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    This teaching guide on earth sciences for 3-year-old children is based on a modification of the "Plan, Do, Review" approach to education devised by High Scope in Ypsilanti, Michigan. First implemented as an outreach early childhood program in North Carolina, the science activities described in this guide can be adapted to various early childhood…

  13. Verbal Competence in Narrative Retelling in 5-Year-Olds with Unilateral Cleft Lip and Palate

    ERIC Educational Resources Information Center

    Klintö, Kristina; Salameh, Eva-Kristina; Lohmander, Anette

    2015-01-01

    Background: Research regarding expressive language performance in children born with cleft palate is sparse. The relationship between articulation/phonology and expressive language skills also needs to be further explored. Aims: To investigate verbal competence in narrative retelling in 5-year-old children born with unilateral cleft lip and palate…

  14. Intellectual Assessment of 111 Four-Year-Old Children with Phenylketonuria

    ERIC Educational Resources Information Center

    Dobson, James C.; And Others

    1977-01-01

    Available from: Arthur Retlaw and Associates, Inc., Suite 2080, 1603 Orrington Avenue, Evanston, Illinois 60201. A sample of 4-year-old children (n=111) with PKU (phenylketonuria) who were placed on dietary therapy between 3 and 92 days of age were assigned to two treatment groups based on "moderate" and "low" serum…

  15. Eosinophilic keratitis and keratoconjunctivitis in a 7-year-old domestic shorthaired cat

    PubMed Central

    2005-01-01

    Abstract A 7-year-old, spayed female, domestic shorthair was presented with a several-month history of an ulcerated right cornea with marked stromal edema and inflammation that was nonresponsive to therapy. A diagnosis of eosinophilic keratitis was made, based on cytologic examination of corneal scrapings. The lesion resolved after treatment with topical corticosteroids. PMID:16363332

  16. Four-Year-Olds' Beliefs about How Others Regard Males and Females

    ERIC Educational Resources Information Center

    Halim, May Ling; Ruble, Diane N.; Tamis-LeMonda, Catherine S.

    2013-01-01

    Children's awareness of how others evaluate their gender could influence their behaviours and well-being, yet little is known about when this awareness develops and what influences its emergence. The current study investigated culturally diverse 4-year-olds' ("N" = 240) public regard for gender groups and whether exposure to factors that…

  17. Phonetic Disintegration in a Five-Year-Old following Sudden Hearing Loss.

    ERIC Educational Resources Information Center

    Binnie, Carl A.; And Others

    1982-01-01

    The speech of a five year old boy who suffered a profound hearing loss following meningitis was sampled at two week intervals for nine months. It was speculated that phonetic processes such as diphthongization, syllabification, and prolonged duration may be strategies for enhancing feedback during speech. (Author)

  18. How "Green" Are Today's 15-Year-Olds? PISA in Focus. No. 15

    ERIC Educational Resources Information Center

    OECD Publishing (NJ1), 2012

    2012-01-01

    How "green" are 15-year-olds? To what extent do they understand environmental issues? What are the sources of their information about the environment? Can they apply scientific principles and evidence to the world around them? This paper reports that across OECD (Organisation for Economic Cooperation and Development) countries, around…

  19. [Giant simple hepatic cysts as dyspnea symptom in a 93-year-old patient].

    PubMed

    Macho Pérez, O; Gómez Pavón, J; Núñez González, A; Narvaiza Grau, L; Albéniz Aguiriano, L

    2007-03-01

    Giant simple hepatic cysts is generally asymptomatic in the 3% of cases of adult patients. We present a woman case of 93 years old who was diagnoses of giant simple hepatic cyst presented as dysnea. The management of this patient was with percutaneous aspiration and fenol alcohol. It made a review of cystic lesions of the liver and of simple hepatic cysts management.

  20. A Resource Guide for an Exploratory Curriculum for Three-Year Old Migrant Children.

    ERIC Educational Resources Information Center

    Hoffman, Stevie; Mottola, Niel

    The rational for the curriculum design for three-year-old migrant children in an expanded-day educational program is presented. Consideration is given for each of the program phases, the learning environment, the rationale for a pre-service workshop and on-going in-service consultancy. This curriculum is based on the premise that, because of the…

  1. Meritocratic Sharing Is Based on Collaboration in 3-Year-Olds

    ERIC Educational Resources Information Center

    Hamann, Katharina; Bender, Johanna; Tomasello, Michael

    2014-01-01

    The present study investigated young preschoolers' proportional allocation of rewards in 2 different work contexts. We presented 32 pairs of 3.5-year-old peers with a collaborative task to obtain rewards by pulling ropes. In order to establish differences in work input, 1 child's rope was not immediately accessible but had to be retrieved from the…

  2. Turning Believers into Skeptics: 3-Year-Olds' Sensitivity to Cues to Speaker Credibility

    ERIC Educational Resources Information Center

    Jaswal, Vikram K.; Malone, Lauren S.

    2007-01-01

    Under most circumstances, children (and adults) can safely assume that the testimony they hear is true. In two studies, we investigated whether 3-year-olds (N = 100) would continue to hold this assumption even if the person who provided the testimony behaved in an uncertain, ignorant, and/or distracted manner. In Study 1, children were less likely…

  3. Examining Communicative Behaviors in a 3-Year-Old Boy Who Is Blind.

    ERIC Educational Resources Information Center

    Perfect, Michelle M.

    2001-01-01

    The communication patterns of a 3-year-old boy who is blind were observed during 35 videotaped classroom sessions to determine if his echolalic responses varied according to school activity and message category. Analysis revealed that, although the child was expressive with adults, he had difficulty communicating with his peers and in producing…

  4. An Experiment on Impatiens New Guinea for 11-12 Year Olds

    ERIC Educational Resources Information Center

    McEwan, Birgitta

    2008-01-01

    The following experiment describes an easy experiment for children 11-12 years old, performed during spring in a compulsory school near Karlstad, Sweden. Four different ripe fruits were placed under flowering plants of Impatiens New Guinea (Impatiens hawkeri) for four days on a table and with plastic bags around both plants and fruits. For one of…

  5. Dental Management of a 14-Year-Old with Cockayne Syndrome under General Anesthesia

    PubMed Central

    Gaddam, Divya; Thakur, Mukesh Singh; Krothapalli, Niranjani; Kaniti, Saujanya

    2014-01-01

    Cockayne's syndrome is a rare, autosomal recessive disorder characterized clinically by cachectic dwarfism, cutaneous photosensitivity, loss of adipose tissue, mental retardation, skeletal and neurological abnormalities, and pigmentary degeneration of the retina. Dental caries is a common finding. Dental rehabilitation of a 14-year-old male with Cockayne's syndrome is presented. PMID:25574402

  6. Tetralogy of Fallot in a 6-year-old albino ferret (Mustela putorius furo)

    PubMed Central

    Laniesse, Delphine; Hébert, Julie; Larrat, Sylvain; Hélie, Pierre; Pouleur-Larrat, Bénédicte; Belanger, Marie C.

    2014-01-01

    Tetralogy of Fallot associated with bidirectional shunting across a large ventricular septal defect, was found in a 6-year-old ferret. The prognosis associated with tetralogy of Fallot is usually poor. This case is interesting given the advanced age of the ferret. The bidirectional shunting, responsible for an acyanotic disease, may explain the unexpected prolonged survival in this ferret. PMID:24790231

  7. Characteristics of 15-Year-Old Students Predicting Scientific Literacy Skills in Turkey

    ERIC Educational Resources Information Center

    Demir, Ergül

    2016-01-01

    Since 2003, Turkey regularly participates in PISA. According to the PISA 2012 results, 15-year-old students in Turkey performed below both OECD countries and participating countries. Defining the relations between students' characteristics and their scientific literacy skills is thought to provide deeper understanding for the nature of this…

  8. One- to Three-Year-Old Children's Experience of Subjective Wellbeing in Day Care

    ERIC Educational Resources Information Center

    Seland, Monica; Sandseter, Ellen Beate Hansen; Bratterud, Åse

    2015-01-01

    The aim of the study on which this paper is based was to explore in which situations and contexts Norwegian 1-3-year-olds experience subjective wellbeing in day care. The data in this study was collected through qualitative phenomenological observations of 18 children, and an inductive process of analysis was conducted. The results show that…

  9. Words, Shape, Visual Search and Visual Working Memory in 3-Year-Old Children

    ERIC Educational Resources Information Center

    Vales, Catarina; Smith, Linda B.

    2015-01-01

    Do words cue children's visual attention, and if so, what are the relevant mechanisms? Across four experiments, 3-year-old children (N = 163) were tested in visual search tasks in which targets were cued with only a visual preview versus a visual preview and a spoken name. The experiments were designed to determine whether labels facilitated…

  10. A 58-Year-Old Female with Progressive Cough and Right Shoulder Pain

    PubMed Central

    Thakore, Sanket R.

    2016-01-01

    Cavitary pneumonia in immunocompromised patients is a challenging entity. Establishing accurate diagnosis and starting effective antibiotics are essential steps towards improving outcome. A 58-year-old stem cell transplant patient was admitted to the hospital with necrotizing pneumonia caused by nocardia. The disease progressed despite of aggrieve antimicrobial therapy. Nocardiosis continues to be a difficult disease to diagnose and treat. PMID:27872648

  11. Kienböck's disease in a 6-year-old boy.

    PubMed

    Docquier, Pierre-Louis; Traore, Alidou; Hugon, Sébastien

    2009-12-01

    A case of avascular necrosis of the lunate bone in a 6-year-old boy is reported. This is the youngest child reported in literature with Kienböck's disease. Clinical and radiological healing was obtained with conservative treatment. Non-operative management is recommended in children with avascular necrosis of the lunate bone.

  12. Polydrug Use among 15- to 16-Year Olds: Similarities and Differences in Europe

    ERIC Educational Resources Information Center

    Olszewski, Deborah; Matias, Joao; Monshouwer, Karin; Kokkevi, Anna

    2010-01-01

    Aims: We describe types of polydrug use among school students across Europe and explore differences between high, medium and low drug prevalence countries. Method: Analysis is based on survey data from over 70,000 15- to 16-year-old school students in 22 European countries. Polydrug use (defined as the use of two or more listed substances during…

  13. Factors that Influence Vocabulary Development in Two-Year-Old Children

    ERIC Educational Resources Information Center

    Stokes, Stephanie F.; Klee, Thomas

    2009-01-01

    Background: This research explored the relative impact of demographic, cognitive, behavioural, and psycholinguistic factors on vocabulary development in two-year-old children. Methods: Two hundred and thirty-two children (24-30 months) were tested on expressive and receptive vocabulary, cognitive development, word learning and working memory…

  14. Through Another's Eyes: Elements in the Eyes of a 4-Year-Old

    ERIC Educational Resources Information Center

    Hu, Xuan

    2004-01-01

    My husband, who is a scientist, often brings home different scientific journals and magazines to read, and my 4-year-old son, Nicholas J. Hu, likes to flip through them. A recent issue of Chemical and Engineering News (September, 2003) caught his interest more than usual because there were stories of different elements. Nicholas has been able to…

  15. Multifocal leiomyosarcomatosis in a 6-year-old child with epidermodysplasia verruciformis and immune defect.

    PubMed

    Boybeyi, Ozlem; Akçören, Zuhal; Oğuz, Berna; Akyüz, Canan; Sanal, Ozden; Ergin, Sibel; Ersoy-Evans, Sibel; Tanyel, F Cahit

    2009-07-01

    Leiomyosarcoma and epidermodysplasia verruciformis are rarely encountered in children. The association of either leiomyosarcoma or epidermodysplasia verruciformis with immune deficiency has previously been documented. A 6-year-old girl, who has had multifocal leiomyosarcomatosis after the previous diagnoses of epidermodysplasia verruciformis and immune defect, represents an interesting association of these features.

  16. Perceived, Expressed and Observed Prosociality among Four-Year-Old Girls and Boys in Childcare Centres

    ERIC Educational Resources Information Center

    Bouchard, Caroline; Coutu, Sylvain; Bigras, Nathalie; Lemay, Lise; Cantin, Gilles; Bouchard, Marie-Claire; Duval, Stéphanie

    2015-01-01

    This article examines the prosociality of four-year-old girls and boys in childcare centres. More specifically, it aims to measure gender differences in prosociality among children, based on three sources and methods of evaluation: (1) the early childhood educator's (ECE) perception (perceived prosociality), (2) the children's own responses to…

  17. Teaching Mathematical Concepts to Two- and Three-year-olds: Some Experimental Studies.

    ERIC Educational Resources Information Center

    Greenfield, Patricia Marks

    Experiments conducted to find ways of teaching two and three year olds mathematical concepts were found to have general implications for concept learning. The failure of an initial attempt to teach the concepts "fat" and "skinny" led to a design of instructional procedures that would utilize a concept's name while trying to teach its semantic…

  18. Two-Year-Olds Learn Novel Nouns, Verbs, and Conventional Actions from Massed or Distributed Exposures.

    ERIC Educational Resources Information Center

    Childers, Jane B.; Tomasello, Michael

    2002-01-01

    Examined 2-year-olds' comprehension and production of novel nouns, verbs, or actions at 3 intervals after training conducted in massed or distributed exposures. Found that for comprehension, children learned all item types in all training conditions at all retention intervals. Production was better for nonverbal actions than for either word type…

  19. Dimensions of Oppositional Defiant Disorder in 3-Year-Old Preschoolers

    ERIC Educational Resources Information Center

    Ezpeleta, Lourdes; Granero, Roser; de la Osa, Nuria; Penelo, Eva; Domenech, Josep M.

    2012-01-01

    Background: To test the factor structure of oppositional defiant disorder (ODD) symptoms and to study the relationships between the proposed dimensions and external variables in a community sample of preschool children. Method: A sample of 1,341 3-year-old preschoolers was randomly selected and screened for a double-phase design. In total, 622…

  20. Obstructive urolithiasis, unilateral hydronephrosis, and probable nephrolithiasis in a 12-year-old Clydesdale gelding.

    PubMed

    Macbeth, Bryan J

    2008-03-01

    A 12-year-old Clydesdale gelding was presented for colic and dysuria. Obstructive urolithiasis and chronic renal disease were diagnosed via transurethral endoscopy and percutaneous ultrasonography. Nephroliths, hydronephrosis, and peri-ureteral fibrosis were present. Surgical intervention was declined and the gelding was managed medically with antibiotics and dietary modification.

  1. Preschool Teachers' Shared Beliefs about Appropriate Pedagogy for 4-Year-Olds

    ERIC Educational Resources Information Center

    Lee, Joon Sun

    2006-01-01

    The 18 preschool teachers in the study tended to agree that preschool education for 4-year-olds should foremost be fun and engaging, not stressful. Teachers should develop curricula based on children's interests and everyday lives, and allow children to choose their activities and to direct their own play and exploration at their own pace. The…

  2. What Is Appropriate Mathematics Education for Four-Year-Olds?: Pre-Kindergarten Teachers' Beliefs

    ERIC Educational Resources Information Center

    Lee, Joon Sun; Ginsburg, Herbert P.

    2007-01-01

    This study explored pre-kindergarten teachers' beliefs about the appropriateness of early mathematics education. Thirty pre-kindergarten teachers of four-year-olds, half working with low-SES children at publicly funded pre-kindergartens and the other half with middle-SES children at private pre-kindergartens, were interviewed concerning written…

  3. Narrative Comprehension Skills in 5-Year-Old Children: Correlational Analysis and Comprehender Profiles

    ERIC Educational Resources Information Center

    Potocki, Anna; Ecalle, Jean; Magnan, Annie

    2013-01-01

    This study was designed to examine whether a variety of cognitive and linguistic factors theoretically considered to be predictive of reading comprehension skills in elementary school children were also predictive of listening comprehension skills in 131 five-year-old children. The results showed that the predictors of young children's listening…

  4. Phonological Awareness and Emerging Reading Skills of Two- to Five-Year-Old Children

    ERIC Educational Resources Information Center

    Suortti, Outi; Lipponen, Lasse

    2016-01-01

    This study, conducted in Finnish private and Montessori child care centres, aimed at investigating the development of the phonological awareness (PA) of two- to five-year-old preschool children within a six-month period in relation to emerging letter knowledge and reading skills. The children (N = 72) performed five phonological tasks and a…

  5. Psychosocial Family Treatment for a 10-Year-Old with Schizoaffective Disorder

    ERIC Educational Resources Information Center

    Klaus, Nicole M.; Fristad, Mary A.; Malkin, Catherine; Mackinaw-Koons, Barbara

    2008-01-01

    Schizophrenia spectrum disorders are rare in childhood and little is known about their psychosocial treatment. Relevant findings from the adult and child literature are reviewed. The case of 10-year-old "Michael" is presented, who participated in a randomized clinical trial of a psychoeducational family treatment for mood disorders. Following…

  6. Intonation Facilitates Contrast Resolution: Evidence from Japanese Adults and 6-Year Olds

    ERIC Educational Resources Information Center

    Ito, Kiwako; Jincho, Nobuyuki; Minai, Utako; Yamane, Naoto; Mazuka, Reiko

    2012-01-01

    Two eye-tracking experiments tested how pitch prominence on a prenominal adjective affects contrast resolution in Japanese adult and 6-year old listeners. Participants located two animals in succession on displays with multiple colored animals. In Experiment 1, adults' fixations to the contrastive target (pink cat [right arrow] GREEN cat) were…

  7. Home Computer Use and Academic Performance of Nine-Year-Olds

    ERIC Educational Resources Information Center

    Casey, Alice; Layte, Richard; Lyons, Sean; Silles, Mary

    2012-01-01

    A recent rise in home computer ownership has seen a growing number of children using computers and accessing the internet from a younger age. This paper examines the link between children's home computing and their academic performance in the areas of reading and mathematics. Data from the nine-year-old cohort of the Growing Up in Ireland survey…

  8. Relationship Between Affective Determinants and Achievement in Science for Seventeen-Year-Olds.

    ERIC Educational Resources Information Center

    Napier, John D.; Riley, Joseph P.

    1985-01-01

    Data collected in the 1976-1977 National Assessment of Educational Progress survey of 17-year-olds was used to reanalyze the hypothesis that there are affective determinants of science achievement. Results show that motivation, anxiety, student choice, and teacher support account for most of the correlation between affective determinants and…

  9. School and Work in Prospect: 14-Year-Olds in Australia. ACER Research Monograph No. 10.

    ERIC Educational Resources Information Center

    Williams, Trevor; And Others

    A study examined the educational and occupational plans of Australian fourteen-year-olds as part of program of research on the transition to adulthood. A twenty-item questionnaire was administered to 969 students in 243 schools across Australia. The questionnaire contained items pertaining to respondents' State of residence, school system…

  10. The Relation of Temperament and Social Factors to Behavior Problems in Three-Year-Old Children.

    ERIC Educational Resources Information Center

    Barron, A.P.; Earls, F.

    1984-01-01

    Investigates the relationship of temperament characteristics and social factors to behavior adjustment among 90 three-year-old children. Inflexibility of child, negative parent/child interaction, and high family stress are highly associated with poor behavior adjustment. A path analysis suggests that flexibility and positive interaction diminish…

  11. Peer Competence and Mother-Child and Child-Child Interactions in One-Year-Olds.

    ERIC Educational Resources Information Center

    van Lieshout, Cornelis F. M.; And Others

    As part of a longitudinal study of the predictors of preschool-aged children's peer relationships, data were collected on the social behavior of 1-year-olds. Participating in the study were 48 mother-child dyads. Individual and comparison data were gathered through observation and videotape recordings in laboratory dyadic play sessions involving…

  12. Handedness in Swedish 10-year-olds, Some Background and Associated Factors.

    ERIC Educational Resources Information Center

    Gillberg, Christopher; And Others

    1984-01-01

    Aims to obtain prevalence figures for left-handedness among 10-year-old Swedish children; to replicate some findings concerning Bishop's (1980) extended pathological left-handedness hypothesis; to evaluate the influence of factors such as the child's sex and reduced optimality in the pre-, peri-, and neonatal period; and to determine the…

  13. Effectiveness of Multipurpose Unit Early Classroom Intervention Program for 4-5-Year-Old Children

    ERIC Educational Resources Information Center

    Celebioglu Morkoc, Ozlem; Aktan Acar, Ebru

    2014-01-01

    This research examined the effectiveness of Multipurpose Unit Early Classroom Intervention Program (MUECIP) prepared for 4-5-year-old (48-60 months) children whose development is at risk because of their families' socioeconomic conditions. The research adopted a preliminary test-final test control group trial model. The research participants were…

  14. Childhood Trauma and Multiple Personality Disorder: The Case of a 9-Year-Old Girl.

    ERIC Educational Resources Information Center

    LaPorta, Lauren D.

    1992-01-01

    This paper reports the case of a nine-year-old female victim of sexual abuse, evaluated and diagnosed with multiple personality disorder over a six-month period. Included is a description of the child's presentation with historical and developmental data. A discussion of the dynamic and predisposing features of the case follows, along with…

  15. Two-Year-Old Children Differentiate Test Questions from Genuine Questions

    ERIC Educational Resources Information Center

    Grosse, Gerlind; Tomasello, Michael

    2012-01-01

    Children are frequently confronted with so-called "test questions". While genuine questions are requests for missing information, test questions ask for information obviously already known to the questioner. In this study we explored whether two-year-old children respond differentially to one and the same question used as either a genuine question…

  16. Four Year Old Children's Acquisition of Print Knowledge during Electronic Storybook Reading

    ERIC Educational Resources Information Center

    Gong, Zhiyu; Levy, Betty Ann

    2009-01-01

    The experiment reported here explored the importance of engaging 4-year-old children's interest in the print itself during storybook reading. We explored the effect of computer animation of the print in order to draw the child's attention to each word as it was read. We also investigated the influence of illustrating that not all visual displays…

  17. What Would You Look Like If You Were 100 Years Old?

    ERIC Educational Resources Information Center

    Petersen, Hugh

    1998-01-01

    Describes a project inspired by the 100th day of school in which first-grade students created a self-portrait of themselves at 100 years old and wrote an accompanying essay. States that the students drew wrinkles on the faces, age-appropriate clothing, gray or white hair, and even glasses as a finishing touch. (CMK)

  18. Thoracoscopic resection of a bronchogenic cyst in a 17-year-old girl

    PubMed Central

    Pułtorak, Roksana; Pasierbek, Michał; Grabowski, Andrzej

    2016-01-01

    Bronchogenic cysts comprise approximately 6% of mediastinal tumors in children. The treatment consists in surgical resection of the cyst. The authors present the case of a 17-year-old girl who was accidentally diagnosed with a mediastinal cyst. The patient was successfully treated with thoracoscopic surgery with good early and late clinical outcomes. PMID:28096839

  19. Myocardial infarction in a 17-year-old patient due to neurofibromatosis-associated coronary aneurysm.

    PubMed

    Evrengul, Harun; Kilic, Dogu I; Zungur, Mustafa; Alihanoglu, Yusuf I; Tanriverdi, Halil

    2013-06-01

    Neurofibromatosis is an autosomal dominant multi-system genetic disorder. Extra-cardiac vascular manifestations of neurofibromatosis have been previously described in many reports. However, coronary arterial involvements have been rarely described. A 17-year-old girl with neurofibromatosis presented to our institute with subacute myocardial infarction. Coronary angiogram revealed an aneurysm with thrombus in the left anterior descending artery.

  20. Understanding Linear and Exponential Growth: Searching for the Roots in 6- To 9-Year-Olds

    ERIC Educational Resources Information Center

    Ebersbach, Mirjam; Van Dooren, Wim; Van den Noortgate, Wim; Resing, Wilma C. M.

    2008-01-01

    Previous studies have suggested that children as young as 9 years old have developed an understanding of non-linear growth processes prior to formal education. The present experiment aimed at investigating this competency in even younger samples (i.e., in kindergartners, first, and third graders, ages 6, 7 and 9, respectively). Children (N=90)…

  1. Implicit and Explicit Knowledge of Linear and Exponential Growth in 5- and 9-Year-Olds

    ERIC Educational Resources Information Center

    Ebersbach, Mirjam; Resing, Wilma C. M.

    2008-01-01

    The present study examined children's implicit and explicit knowledge of linear and non-linear processes. Five- and nine-year-olds (N = 60) were asked to forecast linear and exponential growth by providing the corresponding number of beads. Implicit knowledge was assessed via the magnitudes of the forecasts; explicit knowledge was investigated…

  2. Physiological Alterations in 7- to 9-Year-Old Boys Following a Season of Competitive Wrestling.

    ERIC Educational Resources Information Center

    Clarke, David H.; And Others

    1984-01-01

    Muscular and aerobic capacity changes resulting from three months of wrestling training were examined in a group of normally active seven- to nine-year-old boys. Wrestling training was found to improve strength in young boys, but it did not seem to improve aerobic capacity. (Author/DF)

  3. Analyzing the Responses of 7-8 Year Olds When Solving Partitioning Problems

    ERIC Educational Resources Information Center

    Badillo, Edelmira; Font, Vicenç; Edo, Mequè

    2015-01-01

    We analyze the mathematical solutions of 7- to 8-year-old pupils while individually solving an arithmetic problem. The analysis was based on the "configuration of objects," an instrument derived from the onto-semiotic approach to mathematical knowledge. Results are illustrated through a number of cases. From the analysis of mathematical…

  4. The Development of the Concepts of Heat and Temperature in 10-13 Year-Olds.

    ERIC Educational Resources Information Center

    Shayer, Michael; Wylam, Hugh

    1981-01-01

    Describes the development of a Piagetian demonstration group test utilized to assess 9-12 year-old students' (N=161) understanding of heat and temperature. Findings include a unitary relationship between Piagetian stages of development and levels of understanding of heat concepts. (DS)

  5. Five- to 8-Year-Old Emirati Children's and Their Teachers' Perceptions of War

    ERIC Educational Resources Information Center

    Buldu, Mehmet

    2009-01-01

    This study examined 5- to 8-year-old Emirati children's and their teachers' perceptions of war. Data for this study were collected through drawings and semi-structured interviews. A phenomenological procedure was used to analyze the data. Younger children could not articulate the details of the specific nature of war. Many children defined war as…

  6. Parental Strategies and Trajectories of Peer Victimization in 4 to 5 Year Olds

    ERIC Educational Resources Information Center

    Bonnet, Marielle; Goossens, Frits A.; Schuengel, Carlo

    2011-01-01

    This study was designed to examine how parental strategies contribute to explaining trajectories of peer victimization in young children. A total of 73 4 and 5 year old children identified as victims of peer aggression in the fall semester and their parents were recruited from 46 classrooms in 18 schools in the Netherlands. All children were…

  7. Puns, Metaphors, and Misunderstandings in a Two-year Old's Conception of Death

    ERIC Educational Resources Information Center

    Brent, Sandor B.

    1978-01-01

    This paper reports, analyzes, and interprets successive stages in the evolution of one two-year old boy's conception of death through a series of puns, metaphors, and misunderstandings about the nature of language, and of its relationship to the world to which it refers. (Author)

  8. Lullaby Light Shows: Everyday Musical Experience among Under-Two-Year-Olds

    ERIC Educational Resources Information Center

    Young, Susan

    2008-01-01

    This article reports on information gathered from a set of interviews carried out with 88 mothers of under-two-year-olds. The interviews enquired about the everyday musical experiences of their babies and very young children in the home. From the process of analysis, the responses to the interviews were grouped into three main areas: musical…

  9. Early Childhood Settings and Funded Two-Year-Old Children: Experiences from Four Settings in England

    ERIC Educational Resources Information Center

    Phair, Heleanna; Davis, Geraldine

    2015-01-01

    In 2013 funding was introduced to support disadvantaged two-year-old children to attend early childhood settings in England. This study explores the experiences of four early childhood settings as they worked with these funded children for the first time. Using interviews and observations within the settings, findings demonstrate some adjustment…

  10. School Enrollment of 3- and 4-Year-Olds, by Race/Ethnic Category.

    ERIC Educational Resources Information Center

    Kahn, Gerald

    Based on data collected by the U.S. Bureau of the Census in its October 1980 Current Population Survey, this report examines school enrollment rates of 3- and 4-year-olds from three major ethnic groups (black, white, and Spanish origin) and relates this information to characteristics of the children's schools and households. Variables covered in…

  11. Collaboration between 3- and 4-Year-Olds in Self-Initiated Play on Instruments

    ERIC Educational Resources Information Center

    Young, Susan

    2008-01-01

    This article reports on a study of collaborative music-making on instruments among 3- and 4-year-old children. An area equipped with musical instruments was provided as a free-choice play option in an early childhood setting and a fixed camera recorded the children's play continuously during a number of visits. From the total 17 h of data five…

  12. Developmental Trajectory of Rule Detection in Four- to Six-Year-Old Children

    ERIC Educational Resources Information Center

    Li, Wei; Cao, Bihua; Hu, Lijuan; Li, Fuhong

    2017-01-01

    Children younger than three years old are able to detect hidden rules in numerical sequences, and this ability matches that of adults by age seven. However, the developmental trajectory of this ability during the ages of four to six remains unknown. The present study adopted a modified Brixton task to address this issue. In this task, children…

  13. Cat-scratch disease with severe pleuritis in a 6-year-old girl.

    PubMed

    Kimura, Sasagu; Hasegawa, Shunji; Yanagihara, Masashi; Inoue, Hirofumi; Matsushige, Takeshi; Tsuneoka, Hidehiro; Ichiyama, Takashi; Ohga, Shouichi

    2015-06-01

    We present the case of a 6-year-old girl with cat-scratch disease (CSD), who developed severe pleuritis without lymphadenitis. Bartonella henselae DNA was detected on real-time polymerase chain reaction (PCR) analysis of whole blood. This is the first report of CSD diagnosed on real-time PCR using whole blood.

  14. Radiator-induced erythema ab igne in 8-year-old girl.

    PubMed

    Brzezinski, Piotr; Ismail, Samir; Chiriac, Anca

    2014-04-01

    The cutaneous lesion of erythema ab Igne are characterized by a reticulate erythema, hyperpigmentation, fine scaling, epidermal atrophy and telangiectasias, and reticulated erythema. We report a case of erythema ab igne on the hands of a 8-year-old girl, induced by classic homemade radiator.

  15. Adenosarcoma ovarii in a 51-year-old woman: case report.

    PubMed

    Garalejić, E; Arsić, B; Perović, M; Vasiljević, M; Usaj, S K; Stanojević, D

    2012-01-01

    This case report presents a 51-year-old woman with an adenosarcoma of ovarian origin which is a very rare tumor. She came for consultation due to abnormal vaginal bleeding. The case also illustrates the difficulty of its correct diagnosis and discusses the possible reasons of wrong preoperative and intraoperative diagnosis.

  16. Two-Year-Olds Interpret Novel Phonological Neighbors as Familiar Words

    ERIC Educational Resources Information Center

    Swingley, Daniel

    2016-01-01

    When children hear a novel word in a context presenting a novel object and a familiar one, they usually assume that the novel word refers to the novel object. In a series of experiments, we tested whether this behavior would be found when 2-year-olds interpreted novel words that differed phonologically from familiar words in only 1 sound, either a…

  17. Septic arthritis of the temporomandibular joint in a 6-year-old child.

    PubMed

    Amos, M J; Patterson, A R; Worrall, S F

    2008-04-01

    Septic arthritis of the temporomandibular joint (TMJ) is rare, and is almost exclusively confined to adults; we know of only four cases previously described in children. We present a 6-year-old girl who had septic arthritis of the temporomandibular joint with no obvious cause. We stress the need for prompt diagnosis and intervention to prevent serious consequences.

  18. Verbal Labels Modulate Perceptual Object Processing in 1-Year-Old Children

    ERIC Educational Resources Information Center

    Gliga, Teodora; Volein, Agnes; Csibra, Gergely

    2010-01-01

    Whether verbal labels help infants visually process and categorize objects is a contentious issue. Using electroencephalography, we investigated whether possessing familiar or novel labels for objects directly enhances 1-year-old children's neural processes underlying the perception of those objects. We found enhanced gamma-band (20-60 Hz)…

  19. Maternal Teaching during Play with Four-Year-Olds: Variation by Ethnicity and Family Resources

    ERIC Educational Resources Information Center

    Tamis-LeMonda, Catherine S.; Sze, Irene Nga-Lam; Ng, Florrie Fei-Yin; Kahana-Kalman, Ronit; Yoshikawa, Hirokazu

    2013-01-01

    Mothers' spontaneous teaching of their 4-year-olds was observed during block play in 230 dyads from low-income African American, Mexican, Dominican, and Chinese backgrounds. Blocks contained graphics that could be used to teach concepts in literacy, math, construction, or body/color. Coders noted how often mothers taught each of the concepts,…

  20. Knowledge of Love: Narratives of Romance Told by 12-Year-Old Children

    ERIC Educational Resources Information Center

    Haldar, Marit

    2013-01-01

    This article reports research on young people's conceptualisations of love and romance through a gender perspective. The data are stories written by 12-year-old girls and boys in Norway who were asked to fantasise about their future love life. Their narratives are explored through discourse analysis and semiotics and analysed within a sociological…

  1. Improving Social Competence through Emotion Knowledge in 2-Year-Old Children: A Pilot Study

    ERIC Educational Resources Information Center

    Giménez-Dasí, Marta; Fernández-Sánchez, Marta; Quintanilla, Laura

    2015-01-01

    Research Findings: The goal of this study was to determine the efficacy of an educational intervention program to improve emotion knowledge, emotion regulation, and social competence in 2-year-old Spanish children. This study makes two original contributions because there are no validated education programs for such young children and because it…

  2. Effect of Rearing Environment on the Feeding Pattern of under Two Years Old Nigerian Children

    ERIC Educational Resources Information Center

    Asekun-Olarinmoye, Esther Olufunmilayo; Lawoyin, Taiwo Olubanke; Asekun-Olarinmoye, Ifeoluwapo Oyebola

    2011-01-01

    With economic pressures on families increasing, more women are working outside the home leaving their children in day care centres. In a community-based, descriptive cross-sectional study, the feeding pattern in two groups of children under two years old, cared for in two different rearing environments: home environment and day care centres, was…

  3. A rare cause of right upper quadrant pain in a 17-year-old female.

    PubMed

    Nwankwo, Nwabundo; Barbaryan, Aram; Ali, Alaa M; Mirrakhimov, Aibek E

    2013-01-01

    A 17-year-old Hispanic female presented to our hospital with complaints of right upper quadrant abdominal pain, vomiting, and fever. Physical exam was positive for hepatomegaly. Abdominal computed tomography showed multiple hypoechoic liver masses. Liver biopsy was done, which was diagnostic for hepatic epithelioid hemangioendothelioma.

  4. Behaviour and Skills in Six-Year-Old Children in a "High Risk" Programme

    ERIC Educational Resources Information Center

    Knivsberg, Ann-Mari; Iversen, Synnove; Nodland, Magne; Reichelt, Karl-L

    2007-01-01

    Problem behaviour hampers learning and the normal development of skills and competencies. The children in focus in this article from Norway are six-year-olds with persistent problem behaviour. Early identification of these children is imperative for the implementation of structured educational interventions. Knowledge about their behaviour and…

  5. BE, DO, and Modal Auxiliaries of 3-Year-Old African American English Speakers

    ERIC Educational Resources Information Center

    Newkirk-Turner, Brandi L.; Oetting, Janna B.; Stockman, Ida J.

    2014-01-01

    Purpose: This study examined African American English--speaking children's use of BE, DO, and modal auxiliaries. Method: The data were based on language samples obtained from 48 three-year-olds. Analyses examined rates of marking by auxiliary type, auxiliary surface form, succeeding element, and syntactic construction and by a number of child…

  6. Fruit and vegetables are similarly categorised by 8-13-year-old children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This exploratory study assessed how 8- to 13-year-old children categorized and labelled fruit and vegetables (FaV), and how these were influenced by child characteristics, to specify second-level categories in a hierarchical food search system for a computerised 24-h dietary recall (hdr). Two sets o...

  7. Mixed foods are similarly categorized by 8-13 year old children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Food search in a computerized 24-h dietary recall (24hdr) for children should be easiest when the categories reflect children's categorization of foods, in contrast to professional categories. This study assessed how 8- to 13-year-old children categorized and labeled mixed foods (e.g., fried rice, l...

  8. Grains are similarly categorized by 8- to 13-year-old children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study assessed how 8- to 13-year-old children categorized and labeled grain foods and how these categories and labels were influenced by child characteristics. The main hypotheses were that children categorized foods in consistent ways and these food categories differed from the professional fo...

  9. Diverse Food Items Are Similarly Categorized by 8- to 13-year-old Children

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The study objective was to assess how 8- to 13-year-old children categorized and labeled food items, for possible use as part of a food search strategy in a computerized 24-hour dietary recall. A set of 62 cards with pictures and names of food items from 18 professionally defined food groups was sor...

  10. Socio-Spatial Practices in a Finnish Daycare Group for One- to Three-Year-Olds

    ERIC Educational Resources Information Center

    Rutanen, Niina

    2012-01-01

    This qualitative case study approaches early childhood education and care practices from a socio-spatial point of view. One Finnish daycare group for one- to three-year-olds participated in the study. The ethnographic observations from the practices are analyzed together with the ECE practitioners' audio-recorded team meetings and video-elicited…

  11. Teaching 3.5-Year-Olds to Revise Their Beliefs Given Ambiguous Evidence

    ERIC Educational Resources Information Center

    Bonawitz, Elizabeth; Fischer, Adina; Schulz, Laura

    2012-01-01

    Previous research suggests that 3-year-olds fail to learn from statistical data when their prior beliefs conflict with evidence. Are children's beliefs entrenched in their folk theories, or can preschoolers rationally update their beliefs? Motivated by a Bayesian account, we conducted a training study to investigate this question. Children (45…

  12. Seasonal and Daily Variation in Physical Activity among Three-Year-Old Finnish Preschool Children

    ERIC Educational Resources Information Center

    Soini, Anne; Tammelin, Tuija; Sääkslahti, Arja; Watt, Anthony; Villberg, Jari; Kettunen, Tarja; Mehtälä, Anette; Poskiparta, Marita

    2014-01-01

    The purposes of this study were to assess seasonal, daily, and gender variations in children's physical activity (PA). ActiGraph GT3X accelerometers were used to record the three-year-old children's PA levels for five consecutive days in autumn and winter. Complete data for both seasons were obtained for 47 children. Despite a significant…

  13. Multiple Intelligences of 6-Year-Old Children Attending Preschool in Turkey

    ERIC Educational Resources Information Center

    Uysal, Ebru; Akyol, Aysel Koksal

    2007-01-01

    This study was designed to examine 6-year-old pupils attending different preschool institutions in Turkey in view of the multiple-intelligences theory. This research aims at determining whether the gender of pupils attending different preschool institutions leads to differences in their verbal-linguistics, mathematical-logical, visual-spatial,…

  14. Cognitive Socialisation of 4-Year-Old Children in Nursery School.

    ERIC Educational Resources Information Center

    Murphy, H. F.; Wilkinson, J. E.

    Using a test-observe-test design with a sample of 29 4-year-old children, this study examined the relationship between children's activity choices in a typical progressive nursery school and their intellectual performance, socioeconomic status (SES), and sex. An attempt was made to identify those experiential factors associated with changes in…

  15. Episodic Memory and Episodic Foresight in 3- and 5-Year-Old Children

    ERIC Educational Resources Information Center

    Hayne, Harlene; Gross, Julien; McNamee, Stephanie; Fitzgibbon, Olivia; Tustin, Karen

    2011-01-01

    In the present study, we examined the development of episodic memory and episodic foresight. Three- and 5-year-olds were interviewed individually using a personalised timeline that included photographs of them at different points in their life. After constructing the timeline with the experimenter, each child was asked to discuss a number of…

  16. Cognitive Components of a Mathematical Processing Network in 9-Year-Old Children

    ERIC Educational Resources Information Center

    Szucs, Dénes; Devine, Amy; Soltesz, Fruzsina; Nobes, Alison; Gabriel, Florence

    2014-01-01

    We determined how various cognitive abilities, including several measures of a proposed domain-specific number sense, relate to mathematical competence in nearly 100 9-year-old children with normal reading skill. Results are consistent with an extended number processing network and suggest that important processing nodes of this network are…

  17. Antecedents of Compliance in 2-Year-Olds From a High-Risk Sample.

    ERIC Educational Resources Information Center

    Erickson, Martha Farrell; Crichton, Leslie

    In order to identify antecedents of infant's compliance with mothers' directions on how to solve four tasks (graded in terms of stressfulness to the infant), 194 high-risk mothers and their 2-year-old children were observed on videotape and assessed with a six-point rating scale. Data collected prenatally and postnatally at 3, 6, 12 and 18 months…

  18. Time and Narrative at Eight Years Old: An Essay in Interpretation

    ERIC Educational Resources Information Center

    Armstrong, Michael

    2011-01-01

    This article examines an eight-year-old's story as a literary work which throws light on the extent of a young child's knowledge of the human condition and on the child's capacity to set forth her knowledge in measured prose.

  19. Adults' and 8-Year-Olds' Learning in a Foreign Word Repetition Task: Similar and Different

    ERIC Educational Resources Information Center

    Service, Elisabet; Yli-Kaitala, Hely; Maury, Sini; Kim, Jeong-Young

    2014-01-01

    Although the significance of age in second language acquisition is one of the most hotly debated issues in the field, very few studies have directly addressed age differences in the language learning process. The present study investigated learning in a foreign-word repetition task. Young Finnish adults and 8-year-olds repeated back Korean words.…

  20. Developing Number Knowledge: Assessment, Teaching and Intervention with 7-11 Year Olds. Math Recovery

    ERIC Educational Resources Information Center

    Wright, Robert J.; Ellemor-Collins, David; Tabor, Pamela D.

    2011-01-01

    This fourth book in the Mathematics Recovery series equips teachers with detailed pedagogical knowledge and resources for teaching number to 7 to 11-year olds. Drawing on extensive programs of research, curriculum development, and teacher development, the book offers a coherent, up-to-date approach emphasizing computational fluency and the…

  1. Who Says You Need to Teach Reading to 11-13-Year-Olds?

    ERIC Educational Resources Information Center

    Parkhill, Faye Fiona; Fletcher, Jo Florence; Greenwood, Janinka; Grimley, Michael; Bridges, Sue

    2013-01-01

    Research indicates that as students move through the school system, many begin to experience difficulties with reading. With this mind, this study explored current practices and perceptions about reading programmes for 11-13-year-old students in New Zealand schools. The study employed an online survey designed to investigate current reading…

  2. Repair in the Peer Talk of 6-Year-Old Boys

    ERIC Educational Resources Information Center

    Newbold, Elisabeth J.; Howard, Sara; Wells, Bill

    2011-01-01

    This article reports a qualitative analysis of linguistic and interactional aspects of repair in naturalistic play, interaction between three 6-year-olds (C, D and F), one of whom (child D) displays some speech and language difficulties. The methodology draws on conversation analysis together with perceptual phonetic observation. The analysis…

  3. Developmental Dyscalculia and Basic Numerical Capacities: A Study of 8--9-Year-Old Students

    ERIC Educational Resources Information Center

    Landerl, Karin; Bevan, Anna; Butterworth, Brian

    2004-01-01

    Thirty-one 8- and 9-year-old children selected for dyscalculia, reading difficulties or both, were compared to controls on a range of basic number processing tasks. Children with dyscalculia only had impaired performance on the tasks despite high-average performance on tests of IQ, vocabulary and working memory tasks. Children with reading…

  4. Fantastic Physics: Developing an Early Interest in Science. A Preschool Science Curriculum.(4 Year Old Curriculum).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    Using hands-on activities and the "Plan, Do, Review" approach, this physics curriculum for 4-year-olds is designed to develop an early interest in and enthusiasm for science and to excite children about learning in general. The curriculum is designed to be implemented biweekly in preschool or child care programs but may also be presented…

  5. Fatal cerebral haemorrhage in a hypertensive seven-year-old boy

    PubMed Central

    Brandtner, Herwig; Monticelli, Fabio C; Meyer, Harald J; Biebl, Ariane

    2016-01-01

    A seven-year-old boy died from autopsy-proven brain haemorrhage due to hypertensive vasculopathy. This emphasizes the importance of early diagnosis and therapy of hypertension in children. Brain haemorrhage is a potentially fatal complication of paediatric hypertension. PMID:27688895

  6. Japanese Two-Year-Olds Use Morphosyntax to Learn Novel Verb Meanings

    ERIC Educational Resources Information Center

    Ayumi, Matsuo; Kita, Sotaro; Shinya, Yuri; Wood, Gary C.; Naigles, Letitia

    2012-01-01

    Previous research has found that children who are acquiring argument-drop languages such as Turkish and Chinese make use of syntactic frames to extend familiar verb meanings (Goksun, Kuntay & Naigles, 2008; Lee & Naigles, 2008). This article investigates whether two-year-olds learning Japanese, another argument-drop language, make use of argument…

  7. Tetralogy of Fallot in a 6-year-old albino ferret (Mustela putorius furo).

    PubMed

    Laniesse, Delphine; Hébert, Julie; Larrat, Sylvain; Hélie, Pierre; Pouleur-Larrat, Bénédicte; Belanger, Marie C

    2014-05-01

    Tetralogy of Fallot associated with bidirectional shunting across a large ventricular septal defect, was found in a 6-year-old ferret. The prognosis associated with tetralogy of Fallot is usually poor. This case is interesting given the advanced age of the ferret. The bidirectional shunting, responsible for an acyanotic disease, may explain the unexpected prolonged survival in this ferret.

  8. Normative Childhood Repetitive Routines and Obsessive Compulsive Symptomatology in 6-Year-Old Twins

    ERIC Educational Resources Information Center

    Bolton, Derek; Rijsdijk, Fruhling; Eley, Thalia C.; O'Connor, Thomas G.; Briskman, Jacqueline; Perrin, Sean

    2009-01-01

    Background: To investigate the association between normative repetitive routines of childhood and paediatric obsessive compulsive symptom syndrome (OCSS) and the extent to which it is genetically mediated. Methods: In a two-phase design a community sample of 4,662 6-year-old twin-pairs were sampled and 854 pairs were assessed in the second phase…

  9. Reactive mesothelial hyperplasia associated with chronic peritonitis in a 20-year-old Quarter horse

    PubMed Central

    Hoon-Hanks, Laura L.; Rout, Emily D.; Vap, Linda M.; Aboellail, Tawfik A.; Hassel, Diana M.; Nout-Lomas, Yvette S.

    2016-01-01

    A 20-year-old gelding was diagnosed with peritonitis and severe reactive mesothelial hyperplasia. Exploratory laparotomy findings were suggestive of a neoplastic etiology; however, additional diagnostics ruled this out and the horse made a full recovery. This report demonstrates the difficulty and value of differentiating between reactive and neoplastic mesothelial processes. PMID:27152035

  10. 13-Year-Olds' Perception of Bullying: Definitions, Reasons for Victimisation and Experience of Adults' Response

    ERIC Educational Resources Information Center

    Frisen, Ann; Holmqvist, Kristina; Oscarsson, Daniel

    2008-01-01

    This study formed the second wave of a longitudinal research project examining bullying from the students' perspective. A sample of 877 Swedish 13-year-olds filled out a questionnaire regarding the definition of bullying, reasons for why some students are bullied and the experience of adults' response to bullying. In their definitions, girls were…

  11. Cytological diagnosis of adamantinoma of long bone in a 78-year-old man.

    PubMed

    Gangopadhyay, Mimi; Pramanik, Raghunath; Chakrabarty, Subrata; Bera, Pranati

    2011-01-01

    A clinicohistopathological study of a rare case of adamantinoma of long bone in a 78-year-old patient is presented. The cytological features when evaluated in conjunction with clinical and radiologic features are sufficiently diagnostic. The primary knowledge of its existence and knowledge of its cytological features are important for a correct preoperative cytological diagnosis.

  12. Intermittent pancreatitis in a 2-year-old chihuahua mixed breed dog.

    PubMed

    Chan, Alice K Y

    2006-05-01

    A 2-year-old, female, Chihuahua mixed breed was presented on multiple occasions with vomiting and diarrhea. Diagnostic tests, including blood analyses and ultrasonography, established pancreatitis as the cause of gastrointestinal irritation. Hospitalization and supportive care, followed by maintenance of a prescription gastrointestinal diet, allowed management of the disease.

  13. Social Class, Sex Differences and Performance on Cognitive Tasks Among Two-Year-Old Children.

    ERIC Educational Resources Information Center

    Reppucci, N. Dickon

    The goal of the present study was to investigate the relation between sex, social class as indexed by parental education level, and performance on three different types of cognitive tasks among two year old children. It was expected that social class would be related positively to superior performance on all the tasks for girls but unrelated for…

  14. Reading and General Cognitive Ability: A Multivariate Analysis of 7-Year-Old Twins

    ERIC Educational Resources Information Center

    Harlaar, Nicole; Hayiou-Thomas, Marianna E.; Plomin, Robert

    2005-01-01

    We examined the association between reading and general cognitive ability (g) in a population-based sample of 6,476 pairs of 7-year-old twins. Additive genetic influences largely accounted for individual differences in reading and the covariation between reading and g. Furthermore, both genetic and shared environmental influences on reading and g…

  15. The Effect of Priming on Referential Communication in Four Year Olds.

    ERIC Educational Resources Information Center

    Foorman, Barbara R.

    A study was conducted in light of a neo-Piagetian theory of cognitive development to interpret the effect of priming executive schemes for describing relevant features in a referential communication task. Forty-eight 4-year-old children were divided into primed and nonprimed groups and were asked to describe in isolation a black and white…

  16. Teenage Thinking on Teenage Drinking: 15- to 16-Year Olds' Experiences of Alcohol in Northern Ireland

    ERIC Educational Resources Information Center

    McKay, Michael T.; Cole, Jon C.; Sumnall, Harry

    2011-01-01

    Focus groups were conducted with 15- to 16-year olds in Northern Ireland looking at reasons for alcohol consumption and reflections on specific attitudes towards alcohol and behaviours resulting from alcohol use. Participants reported greater concern with "being caught" drinking by parents than with any negative short- or long-term…

  17. Context and Linguistic Politeness in 7- and 9-Year-Old Italian Children.

    ERIC Educational Resources Information Center

    Axia, Giovanna; Argenti, Emanuela

    The development of linguistic politeness in 7- and 9-year-old Italian children was examined. A total of 80 subjects, 40 males and 40 females, produced requests according to different contexts which were graphically presented. Factors considered for such contexts were: sex of the speaker; sex of the addressee; status of the addressee, either peer…

  18. Development of Face Recognition in 5- to 15-Year-Olds

    ERIC Educational Resources Information Center

    Kinnunen, Suna; Korkman, Marit; Laasonen, Marja; Lahti-Nuuttila, Pekka

    2013-01-01

    This study focuses on the development of face recognition in typically developing preschool- and school-aged children (aged 5 to 15 years old, "n" = 611, 336 girls). Social predictors include sex differences and own-sex bias. At younger ages, the development of face recognition was rapid and became more gradual as the age increased up…

  19. Influence of Emotional Facial Expressions on 3-5-Year-Olds' Face Recognition

    ERIC Educational Resources Information Center

    Freitag, Claudia; Schwarzer, Gudrun

    2011-01-01

    Three experiments examined 3- and 5-year-olds' recognition of faces in constant and varied emotional expressions. Children were asked to identify repeatedly presented target faces, distinguishing them from distractor faces, during an immediate recognition test and during delayed assessments after 10 min and one week. Emotional facial expression…

  20. How Selective Are 3-Year-Olds in Imitating Novel Linguistic Material?

    ERIC Educational Resources Information Center

    Bannard, Colin; Klinger, Jörn; Tomasello, Michael

    2013-01-01

    In 3 studies we explored when 3-year-olds would imitate novel words in utterances produced by adult speakers. Child and experimenter took turns in requesting objects from a game master. The experimenter always went first and always preceded the object's familiar name with a novel adjective (e.g., "the dilsige duck"). In the first 2…

  1. Measuring Implicit Attitudes of 4-Year-Olds: The Preschool Implicit Association Test

    ERIC Educational Resources Information Center

    Cvencek, Dario; Greenwald, Anthony G.; Meltzoff, Andrew N.

    2011-01-01

    The Preschool Implicit Association Test (PSIAT) is an adaptation of an established social cognition measure (IAT) for use with preschool children. Two studies with 4-year-olds found that the PSIAT was effective in evaluating (a) attitudes toward commonly liked objects ("flowers"="good") and (b) gender attitudes ("girl"="good" or "boy"="good"). The…

  2. Hands as Companions of the Mind: Essential Practical Life for the 5-Year-Old

    ERIC Educational Resources Information Center

    Gilder, Sharon Allen

    2012-01-01

    Numerous observations in Montessori classrooms led veteran Montessorians Pamela W. Trumble and Eleni Bokas to the conclusion that a universal need exists to bring integrity back to Practical Life, especially for 5-year-olds. Maria Montessori's observations over a century ago revealed the importance of Practical Life and its relationship to the…

  3. Wakefulness (Not Sleep) Promotes Generalization of Word Learning in 2.5-Year-Old Children

    ERIC Educational Resources Information Center

    Werchan, Denise M.; Gómez, Rebecca L.

    2014-01-01

    Sleep enhances generalization in adults, but this has not been examined in toddlers. This study examined the impact of napping versus wakefulness on the generalization of word learning in toddlers when the contextual background changes during learning. Thirty 2.5-year-old children (M = 32.94, SE = 0.46) learned labels for novel categories of…

  4. PUBIS STRESS FRACTURE IN A 15-YEAR-OLD SOCCER PLAYER

    PubMed Central

    Bertolini, Fabrício Melo; Vieira, Rodrigo Barreiros; Oliveira, Lucas Henrique Araujo de; Lasmar, Rodrigo Pace; Junior, Otaviano de Oliveira

    2015-01-01

    This case report presents a 15-year-old football player who was diagnosed with a pubis stress fracture and underwent conservative treatment with satisfactory results. After a review of the literature, the clinical picture, diagnosis and treatment are described. The importance of this paper comes from the rarity of finding reports about this kind of injury in the literature. PMID:27027039

  5. The Facilitative Effect of Positive Stimuli on 3-Year-Olds' Flexible Rule Use

    ERIC Educational Resources Information Center

    Qu, Li; Zelazo, Philip David

    2007-01-01

    This study examined the effect of emotional stimuli on 3- to 4-year old children's flexible rule use, as measured by the Dimensional Change Card Sort (DCCS). In Experiment 1, children in two countries (Canada and China) were given 2 versions of the DCCS. The Standard version required children to sort red and blue boats and rabbits first by shape…

  6. Supporting the Development of Number Fact Knowledge in Five- and Six-Year-Olds

    ERIC Educational Resources Information Center

    Young-Loveridge, Jenny; Bicknell, Brenda

    2014-01-01

    This paper focuses on children's number fact knowledge from a study that explored the impact of using multiplication and division contexts for developing number understanding with 34 five- and six-year-old children from diverse cultural and linguistic backgrounds. After a series of focused lessons, children's knowledge of number facts, including…

  7. Defiant Behavior in Two- and Three-Year-Olds: A Vygotskian Approach

    ERIC Educational Resources Information Center

    Keefer, Laura Reynolds

    2005-01-01

    Defiant behavior in two- and three-year-olds is a natural expression of a young child's growing autonomy, and, although frustrating to adults, is a natural phase of a child's socio-emotional growth. L.S. Vygotsky's socio-historical theory of the development included a discussion of "crisis" periods, one of which he felt occurred at age three. The…

  8. [A 35-year-old woman with fever, dyspnea, and pain in the left thigh].

    PubMed

    Picardi, A; Navajas, F; De Iorio, F; Amicarelli, M; Spoto, S; De Galasso, L; Vespaciani Gentilucci, U; Scarlata, S; Zardi, E; Di Cuonzo, G

    2001-01-01

    A thirty-five years old woman during her twelfth pregnancy presented fever and pain at the left thigh. After cesarean delivery dyspnea added to the first two symptoms and pulmonary embolism was suspected. A clinical history revaluation suggested a diagnosis of infectious endocarditis and femoural osteomielitis due to a septic embolus.

  9. Signs of Knowledge: The Appropriation of a Symbolic Skill in a Five-Year-Old

    ERIC Educational Resources Information Center

    Magnusson, Maria; Pramling, Niklas

    2011-01-01

    In this empirical study, the appropriation of a symbolic skill by a five-year old child is analysed. His evolving production and understanding are investigated through his sign-making and his explanations of these when speaking with a researcher. The child is studied in his home. A contrasting case of another child of the same age also making…

  10. Categorization of Regional and Foreign Accent in 5- to 7-Year-Old British Children

    ERIC Educational Resources Information Center

    Floccia, Caroline; Butler, Joseph; Girard, Frederique; Goslin, Jeremy

    2009-01-01

    This study examines children's ability to detect accent-related information in connected speech. British English children aged 5 and 7 years old were asked to discriminate between their home accent from an Irish accent or a French accent in a sentence categorization task. Using a preliminary accent rating task with adult listeners, it was first…

  11. 3-Year-Old Children Make Relevance Inferences in Indirect Verbal Communication

    ERIC Educational Resources Information Center

    Schulze, Cornelia; Grassmann, Susanne; Tomasello, Michael

    2013-01-01

    Three studies investigated 3-year-old children's ability to determine a speaker's communicative intent when the speaker's overt utterance related to that intent only indirectly. Studies 1 and 2 examined children's comprehension of indirectly stated requests (e.g., "I find Xs good" can imply, in context, a request for…

  12. Developing Bilingualism in a Two-Year Old Gujarati-English Learning Child.

    ERIC Educational Resources Information Center

    Christian, Jane M.

    This document is a report on English acquisition by a 2-year old Gujarati-speaking child. Overall language development is dealt with only partially. Two aspects of this development are concentrated on. These are (1) phonological accomodation of English and Gujarati in a changing and increasing system, and (2) concentration of English lexemes in…

  13. Markers for Persistent Specific Expressive Language Delay in 3-4-Year-Olds

    ERIC Educational Resources Information Center

    Everitt, Andrea; Hannaford, Philip; Conti-Ramsden, Gina

    2013-01-01

    Background: Identifying 3-4-year-olds who are most at risk of persisting language difficulties, and possibly specific language impairment (SLI), is difficult due to the natural variation of language in young children. In older children, markers for SLI have been identified that differentiate between children with and without SLI. It is not known…

  14. Happiness and Depression in the Traditionally Bullied and Cyberbullied 12-Year-Old

    ERIC Educational Resources Information Center

    Uusitalo-Malmivaara, Lotta; Lehto, Juhani E.

    2016-01-01

    This study investigated the overall happiness, school-related happiness, and depression of traditionally bullied and cyberbullied 12-year-old Finnish students. Among the more than 700 participants, traditional bullying (26%) was more frequent than cyberbullying (18%). Receiving insulting text messages or being the subject of offensive comments on…

  15. Diverse Food Items Are Similarly Categorized by 8- to 13-Year-Old Children

    ERIC Educational Resources Information Center

    Beltran, Alicia; Knight Sepulveda, Karina; Watson, Kathy; Baranowski, Tom; Baranowski, Janice; Islam, Noemi; Missaghian, Mariam

    2008-01-01

    Objective: Assess how 8- to 13-year-old children categorized and labeled food items for possible use as part of a food search strategy in a computerized 24-hour dietary recall. Design: A set of 62 cards with pictures and names of food items from 18 professionally defined food groups was sorted by each child into piles of similar food items.…

  16. Slowly but Surely: Adverbs Support Verb Learning in 2-Year-Olds

    ERIC Educational Resources Information Center

    Syrett, Kristen; Arunachalam, Sudha; Waxman, Sandra R.

    2014-01-01

    To acquire the meanings of verbs, toddlers make use of the surrounding linguistic information. For example, 2-year-olds successfully acquire novel transitive verbs that appear in semantically rich frames containing content nouns ("The boy is gonna pilk a balloon"), but they have difficulty with pronominal frames ("He is gonna pilk…

  17. Three- and Four-Year-Old Children's Ability to Use Desire- and Belief-Based Reasoning.

    ERIC Educational Resources Information Center

    Cassidy, Kimberly Wright

    1998-01-01

    This study investigated the relationship of 3-year olds' reliance on desire when predicting behavior and their performance on false-belief tasks. Results suggested that young children may use the desires of the agent, rather than their own desires, to predict behavior in standard false-belief paradigms. Older preschoolers also have difficulty…

  18. The Great Recession and Behavior Problems in 9-Year Old Children

    ERIC Educational Resources Information Center

    Schneider, William; Waldfogel, Jane; Brooks-Gunn, Jeanne

    2015-01-01

    This article examines associations between the Great Recession and 4 aspects of 9-year olds' behavior--aggression (externalizing), anxiety/depression (internalizing), alcohol and drug use, and vandalism-using the Fragile Families and Child Wellbeing Study, a longitudinal birth cohort drawn from 20 U.S. cities (21% White, 50% Black, 26% Hispanic,…

  19. Common Aetiology for Diverse Language Skills in 4 1/2-Year-Old Twins

    ERIC Educational Resources Information Center

    Hayiou-Thomas, Marianna E.; Kovas, Yulia; Harlaar, Nicole; Plomin, Robert; Bishop, Dorothy V. M.; Dale, Philip S.

    2006-01-01

    Multivariate genetic analysis was used to examine the genetic and environmental aetiology of the interrelationships of diverse linguistic skills. This study used data from a large sample of 4 1/2-year-old twins who were tested on measures assessing articulation, phonology, grammar, vocabulary, and verbal memory. Phenotypic analysis suggested two…

  20. Universally-Available Educational Programs for Four-Year-Olds: An Issue of Policy.

    ERIC Educational Resources Information Center

    Thompson, Virginia L.; Molnar, Janice

    In 1985, Edward Koch, Mayor of New York City, established an Early Childhood Education Commission and gave it the task of recommending how best to begin to provide public education for all of the city's 4-year-olds, beginning in September, 1986. After introductory remarks indicating the confluence and interplay of social elements underpinning the…

  1. Two-and 3-Year-Olds Know What Others Have and Have Not Heard

    ERIC Educational Resources Information Center

    Moll, Henrike; Carpenter, Malinda; Tomasello, Michael

    2014-01-01

    Recent studies have established that even infants can determine what others know based on previous visual experience. In the current study, we investigated whether 2-and 3-year-olds know what others know based on previous auditory experience. A child and an adult heard the sound of one object together, but only the child heard the sound of another…

  2. A Learning Trajectory in 6-Year-Olds' Thinking about Generalizing Functional Relationships

    ERIC Educational Resources Information Center

    Blanton, Maria; Brizuela, Bárbara M.; Gardiner, Angela Murphy; Sawrey, Katie; Newman-Owens, Ashley

    2015-01-01

    The study of functions is a critical route into teaching and learning algebra in the elementary grades, yet important questions remain regarding the nature of young children's understanding of functions. This article reports an empirically developed learning trajectory in first-grade children's (6-year-olds') thinking about generalizing functional…

  3. Fantasy Play and Related Cognitive Development in 2- to 6-Year-Olds.

    ERIC Educational Resources Information Center

    Cole, Diane; LaVoie, Joseph C.

    1985-01-01

    Developmental changes in specific types of fantasy play and the relation of role taking, egocentrism, and receptive vocabulary were examined in two- to six-year-olds. Both frequency and duration of material and ideational fantasy play increased with age, but play patterns differed. Data suggest developmental progression from object to person…

  4. Performance of Three-year-old Children on the Beery Visual-Motor Integration Test.

    ERIC Educational Resources Information Center

    Graf, Mercedes Herrera; Hamersma, Richard J.

    1981-01-01

    Beery contends that the Visual-motor Integration Test can be used to identify learning disability as a result of a deficit in visual-motor integration. The results of this study show that no or low correlation exists when the test is administered to three-year-old children. (Author/AL)

  5. Health in a population of eighteen-year-old males in Italy.

    PubMed

    Emanuele, A M; Falivene, C; Previtera, B

    1994-01-01

    A population of 18-year-old males were studied in order to investigate which biohumoral parameters were modified with respect to the so-called "reference values." To achieve our end, we analyzed the distribution curves of some biohumoral parameters, so selected to test various organs and apparatuses. Our results showed a clear incidence of hepatic affections and dislipidemias.

  6. How Do 5-Year-Olds Understand Questions? Differences in Languages across Europe

    ERIC Educational Resources Information Center

    Sauerland, Uli; Grohmann, Kleanthes K.; Guasti, Maria Teresa; Andelkovic, Darinka; Argus, Reili; Armon-Lotem, Sharon; Arosio, Fabrizio; Avram, Larisa; Costa, João; Dabašinskiene, Ineta; de López, Kristine; Gatt, Daniela; Grech, Helen; Haman, Ewa; van Hout, Angeliek; Hrzica, Gordana; Kainhofer, Judith; Kamandulyte-Merfeldiene, Laura; Kunnari, Sari; Kovacevic, Melita; Kuvac Kraljevic, Jelena; Lipowska, Katarzyna; Mejias, Sandrine; Popovic, Maša; Ruzaite, Jurate; Savic, Maja; Sevcenco, Anca; Varlokosta, Spyridoula; Varnava, Marina; Yatsushiro, Kazuko

    2016-01-01

    The comprehension of constituent questions is an important topic for language acquisition research and for applications in the diagnosis of language impairment. This article presents the results of a study investigating the comprehension of different types of questions by 5-year-old, typically developing children across 19 European countries, 18…

  7. PAVEd for Success: An Evaluation of a Comprehensive Preliteracy Program for Four-Year-Old Children

    ERIC Educational Resources Information Center

    Schwanenflugel, Paula J.; Hamilton, Claire E.; Neuharth-Pritchett, Stacey; Restrepo, M. Adelaida; Bradley, Barbara A.; Webb, Mi-Young

    2010-01-01

    The purpose of the study was to evaluate the effectiveness of "PAVEd for Success," comprehensive preliteracy program guidelines to support the development of foundational preliteracy skills in 4 year olds. Prekindergarten teachers received professional development on variables of the program that included a summer institute, after-school…

  8. Gasoline Abuse in a 10-Year-Old Child with Mental Retardation: A Case Report

    PubMed Central

    Joshi, Mohit; Vankar, GK

    2015-01-01

    Inahalant abuse is of increasing interest in India. The age of onset is typically during adolescence. Gasoline inhalant use is rarely reported in adolescents with intellectual deficit. We report a case of petrol dependence in a 10-year-old child with mental retardation. Possible effect of petrol huffing on behavior and cognition is discussed. PMID:25733844

  9. Inequality and the Home Learning Environment: Predictions about Seven-Year-Olds' Language and Literacy

    ERIC Educational Resources Information Center

    Hartas, Dimitra

    2012-01-01

    Using a UK representative sample from the Millennium Cohort Study, the present study examined the unique and cumulative contribution of children's characteristics and attitudes to school, home learning environment and family's socio-economic background to children's language and literacy at the end of Key Stage 1 (age seven-years-old).…

  10. Langerhans cell histiocytosis: recurrent lesions affecting mandible in a 10-year-old patient.

    PubMed

    Loducca, S V; Mantesso, A; Araújo, N S; Magalhães, M H

    2001-01-01

    Hand-Schuller-Christian disease is a multifocal variant of eosinophilic granuloma, characterised by the classical triad of bony lesions, exophthalmos and diabetes insipidus. This case relates recurrent Langerhans' cell histiocytosis lesions presented as destruction of periodontal support associated with diabetes in a 10-year-old patient. Medical history suggests that the case represents a case of Hand-Schuller Christian disease.

  11. Ready, Set, Grow! Health Education for 3-5 Year Olds.

    ERIC Educational Resources Information Center

    Peterson, Paula J.

    Intended for use in family day care, preschool centers, professional preparation institutions, and in homes, this comprehensive health education curriculum for 3- through 5-year-old children contains units designed to sequentially teach concepts about physical health, mental health, family living, and safety. Contents include the following…

  12. The Unfolding of a Pre-Kindergarten Program for Four Year Olds.

    ERIC Educational Resources Information Center

    Bouchard, Ruth Ann; Mackler, Bernard

    This report provides an in-depth description of an early (1965) Head Start classroom for 4-year-olds in Harlem, New York City. It is based on direct, in-class observation, but standardized tests and interviews were also utilized. The teacher is described in terms of her role in the preschool, and her behavior in interaction with children and…

  13. Action-Based Digital Tools: Mathematics Learning in 6-Year-Old Children

    ERIC Educational Resources Information Center

    Dejonckheere, Peter J. N.; Desoete, Annemie; Fonck, Nathalie; Roderiguez, Dave; Six, Leen; Vermeersch, Tine; Vermeulen, Lies

    2014-01-01

    Introduction: In the present study we used a metaphorical representation in order to stimulate the numerical competences of six-year-olds. It was expected that when properties of physical action are used for mathematical thinking or when abstract mathematical thinking is grounded in sensorimotor processes, learning gains should be more pronounced…

  14. Coordination of Lip Muscle Activity by 2-Year-Old Children During Speech and Nonspeech Tasks

    PubMed Central

    Ruark, Jacki L.; Moore, Christopher A.

    2014-01-01

    This investigation was designed to quantify the coordinative organization of lip muscle activity of 2-year-old children during speech and nonspeech behaviors. Electromyographic (EMG) recordings of right upper and lower lip activity of seven 2-year-old children were obtained during productions of chewing, syllable repetition, lip protrusion, and speech (repeated two-word utterances) tasks. Task comparisons revealed that the coordinative organization of upper and lower lip activity is task specific; different coordinative strategies are employed for different tasks. Lip protrusion and syllable repetition tasks yielded strong coupling of upper and lower lip activity. Lip rounding (sentences containing the lip-rounding vowel /u/) and “nonlabial” speech tasks (sentences free of bilabials and lip-rounding vowels) resulted in low coupling of upper and lower lip activity. Moderate levels of coupling of upper and lower lip activity were evident for chewing and bilabial speech tasks (sentences loaded with bilabial plosion). This finding, that the coordinative elements of the perioral system of 2-year-olds are task specific, extends the results of previous studies of adults and children, where task-specific coordinative strategies were employed by the mandibular and perioral systems (Moore, 1993; Moore & Ruark, 1996; Moore, Smith, & Ringel, 1988; Wohlert & Goffman, 1994). The task-dependent coordination of the perioral system of 2-year-olds supports the notion that developing speech and earlier developing oromotor behaviors (i.e., sucking, chewing) are mediated by different control mechanisms. PMID:9430757

  15. Guidelines for Health Assessment and Intervention Techniques for 3, 4, and 5 Year Old Children.

    ERIC Educational Resources Information Center

    Bentley, Judy K.

    These guidelines were developed to help registered nurses identify preschoolers with potential handicaps in the course of health assessments. Contents include guidelines on 3-, 4-, and 5-year-olds. Contents are organized within age levels in terms of functioning levels and anticipatory guidance. Functional areas covered include physical,…

  16. My Body. Developing an Early Interest in Science: A Preschool Science Curriculum. (4-Year-Olds).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    This teaching guide on the body for 4-year-olds is based on a modification of the "Plan, Do, Review" approach to education devised by High Scope in Ypsilanti, Michigan. First implemented as an outreach early childhood program in North Carolina, the science activities described in this guide can be adapted to various early childhood environments.…

  17. Reference values for craniofacial structures in children 4 to 6 years old: review of the literature.

    PubMed

    Hönn, Mirjam; Göz, Gernot

    2007-05-01

    This review article addresses the question as to what methods can be used to investigate cranial structure and growth development in children 4 to 6 years old, and what the relevant reference values are for this age group. We screened the literature for epidemiological, longitudinal and cross-sectional studies investigating healthy children 4 to 6 years old without abnormalities and orthodontic therapy. Radiographic cephalometry is a practical, valid tool for analyzing craniofacial structure and growth processes. But it has several disadvantages, including the use of ionizing radiation, measuring points that are difficult to locate, no means of radiographic enlargement without distorting reference values, and the data's two-dimensionality. Anthropometry is another procedure for creating reference values for the craniofacial structure in children. Its advantages over radiographic cephalometry include three-dimensional results and no radiation exposure. Moreover, it yields precise and valid results for a wide variety of potential applications. In addition to these procedures, there are other techniques with which cranial structure and growth development in children 4 to 6 years old can be investigated. Those reported in the literature in this connection include standardized photographs, the creation of computerized and magnetic resonance images, and investigations performed on dry skulls. In short, there is great demand nowadays for investigations aimed at developing reference values for Caucasian children 4 to 6 years old. Radiographic cephalometry and anthropometry are two very common methods. Anthropometry is expected to become increasingly important because it involves no exposure to radiation.

  18. Ensemble Perception of Size in 4-5-Year-Old Children

    ERIC Educational Resources Information Center

    Sweeny, Timothy D.; Wurnitsch, Nicole; Gopnik, Alison; Whitney, David

    2015-01-01

    Groups of objects are nearly everywhere we look. Adults can perceive and understand the "gist" of multiple objects at once, engaging ensemble-coding mechanisms that summarize a group's overall appearance. Are these group-perception mechanisms in place early in childhood? Here, we provide the first evidence that 4-5-year-old children use…

  19. Frontal Electroencephalogram Activation Asymmetry, Emotional Intelligence, and Externalizing Behaviors in 10-Year-Old Children

    ERIC Educational Resources Information Center

    Santesso, L. Diane; Dana, L. Reker; Schmidt, Louis A.; Segalowitz, Sidney J.

    2006-01-01

    The purpose of the present study was to examine the relations among resting frontal brain electrical activity (EEG) (hypothesized to reflect a predisposition to positive versus negative affect and ability to regulate emotions), emotional intelligence, and externalizing behaviors in a sample of non-clinical 10-year-old children. We found that boys…

  20. Extradural Spinal Schwannoma in 12 Year Old Child : A Case Report

    PubMed Central

    Jeng, Toh Charng; Abdullah, Jafri Malin; George, Jain; Tharakan KJ, John; Casilda, Sharon; Ghazali, Mazira Mohamad; Jaafar, Hasnan; Salmah, Win Mar

    2005-01-01

    We report a case of a 12 year old girl who presented with cord compression. Imaging studies demonstrated an extradural spinal tumour in the lower thoracic and upper lumbar levels. Histology confirmed the diagnosis of schwannoma while associated findings suggested the possibility of Neurofibromatosis Type I. PMID:22605960

  1. Follow Me Too: A Handbook of Movement Activities for Three- to Five-Year-Olds.

    ERIC Educational Resources Information Center

    Torbert, Marianne; Schneider, Lynne B.

    This teacher resource book features 49 organized games that involve active movement and that provide positive play experiences for 3- to 5-year-old children. The games in the book encourage cooperative learning and teamwork, and help children develop important social, emotional, physical, and cognitive skills. In addition to detailed descriptions…

  2. Earth Science. Developing an Early Interest in Science: A Preschool Science Curriculum. (4-Year-Olds).

    ERIC Educational Resources Information Center

    Summer, Gail L.; Giovannini, Kathleen

    This teaching guide on earth sciences for 4-year-olds is based on a modification of the "Plan, Do, Review" approach to education devised by High Scope in Ypsilanti, Michigan. First implemented as an outreach early childhood program in North Carolina, the science activities described in this guide can be adapted to various early childhood…

  3. Biofidelity Evaluation of a Prototype Hybrid III 6 Year-Old ATD Lower Extremity.

    PubMed

    Boucher, Laura C; Bing, Julie; Bolte, John H

    2016-09-01

    Incomplete instrumentation and a lack of biofidelity in the extremities of the 6 year-old anthropomorphic test device (ATD) pose challenges when studying regions of the body known to interact with the vehicle interior. This study sought to compare a prototype Hybrid III 6 year-old ATD leg (ATD-LE), with a more biofidelic ankle and tibia load cell, to previously collected child volunteer data and to the current Hybrid III 6 year-old ATD (HIII). Anthropometry, range of motion (ROM), and stiffness measurements were taken, along with a dynamic evaluation of the ATD-LE using knee-bolster airbag (KBA) test scenarios. Anthropometry values were similar in eight of twelve measurements. Total ankle ROM was improved in the ATD-LE with no bumper compared to the HIII. The highest tibia moments and tibia index values were recorded in KBA scenarios when the toes were positioned in contact with the dashboard prior to airbag deployment, forcing the ankle into axial loading and dorsiflexion. While improvements in the biofidelity of the ATD-LE are still necessary, the results of this study are encouraging. Continued advancement of the 6 year-old ATD ankle is necessary to provide a tool to directly study the behavior of the leg during a motor vehicle crash.

  4. Search for microaustralites in deep-sea sediments less than 20,000 years old

    NASA Technical Reports Server (NTRS)

    Glass, B. P.; Wu, Jiquan

    1992-01-01

    Several authors have proposed that australites fell less than 20,000 years ago. We searched for microtektites in the tops of 46 deep-sea cores and were unable to find evidence for a microtektite layer less than 20,000 years old. Either the australite fall was not accompanied by microtektites, or the strewnfield did not extend into the area searched, or the australites fell about 0.77 Ma ago as indicated by their radiometric ages.

  5. Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma

    PubMed Central

    Posso, Veronica; Redrobán, Ligia

    2016-01-01

    Secretory breast carcinoma is an exceptionally rare mammary gland neoplasia described mainly in adult females and children of both sexes, and very rarely in the elderly. It has particular histopathological and immunohistochemical features and a favorable prognosis. We report the case of a 79-year-old Hispanic woman with a palpable breast mass. Currently, the patient is disease free after a followup period of 6 years without local recurrence or axillary lymph-nodes nor distant metastases. PMID:28058101

  6. Motor Impulsivity during Childhood and Adolescence: A Longitudinal Biometric Analysis of the Go/No-Go Task in 9- to 18-Year-Old Twins

    ERIC Educational Resources Information Center

    Bezdjian, Serena; Tuvblad, Catherine; Wang, Pan; Raine, Adrian; Baker, Laura A.

    2014-01-01

    In the present study, we investigated genetic and environmental effects on motor impulsivity from childhood to late adolescence using a longitudinal sample of twins from ages 9 to 18 years. Motor impulsivity was assessed using errors of commission (no-go errors) in a visual go/no-go task at 4 time points: ages 9-10, 11-13, 14-15, and 16-18 years.…

  7. [Social stratification and nutritional anthropometry in children under 15 years old La Escalera, Lara State, Venezuela].

    PubMed

    Torres-Villanueva, Mario; Dellán-Rodríguez, Graciela; Papale-Centofanti, Jham; Rodríguez, Dioslibeth; Mendoza, Norelis; Berné, Yelitza

    2007-09-01

    Malnutrition is a public health problem for underdeveloped countries. From the 852 million of undernourished estimated by FAO between 2000 and 2002, 815 million belonged to underdeveloped countries, 28 million to countries in transition and 9 million to developed countries. Malnutrition in Venezuela had a 6% raise between 2000 and 2002, when it went from 11% to 17%. This work was done with children under 15 years old from La Escalera, using classic indicators and their combination, relating them with socioeconomic conditions, through the NBI and Graffar Méndez Castellano methods, as to consider the population nutritional profile. The higher prevalence corresponded to normal nutritional values, which oscillated between 55,7% and 80,7% in the 7-14 years old group and the 2-6 years old group, respectively. Malnutrition was found in the under 2 years old group and 7-14 years old group, with values ranging between 12,5 and 41,0% respectively. The least prevalence was found for excess malnutrition. 100% of the families in this study are poor, according to NBI; although the Graffar Mendez Castellano method established that poverty was about 60%, while 40% belonged to a medium-low status. Relating nutritional diagnosis with social stratification and the mother's educational level, three patterns were observed: III, IV and V, prevailing normal diagnosis, followed by malnutrition by deficit and malnutrition by excess, respectively. The predominating mother's educational level corresponded to incomplete high school, followed by analphabetism and the least prevalent has complete basic elementary education. It should be noted that the nutrition deficit was inversely related to the socioeconomic stratification and the mother's educational level.

  8. Development and verification of child observation sheet for 5-year-old children.

    PubMed

    Fujimoto, Keiko; Nagai, Toshisaburo; Okazaki, Shin; Kawajiri, Mie; Tomiwa, Kiyotaka

    2014-02-01

    The aim of the study was to develop a newly devised child observation sheet (COS-5) as a scoring sheet, based on the Childhood Autism Rating Scale (CARS), for use in the developmental evaluation of 5-year-old children, especially focusing on children with autistic features, and to verify its validity. Seventy-six children were studied. The children were recruited among participants of the Japan Children's Cohort Study, a research program implemented by the Research Institute of Science and Technology for Society (RISTEX) from 2004 to 2009. The developmental evaluation procedure was performed by doctors, clinical psychologists, and public health nurses. The COS-5 was also partly based on the Kyoto Scale of Psychological Development 2001 (Kyoto Scale 2001). Further, the Developmental Disorders Screening Questionnaire for 5-Years-Olds, PDD-Autism Society Japan Rating Scale (PARS), doctor interview questions and neurological examination for 5-year-old children, and the Draw-a-Man Test (DAM) were used as evaluation scales. Eighteen (25.4%) children were rated as Suspected, including Suspected PDD, Suspected ADHD and Suspected MR. The COS-5 was suggested to be valid with favorable reliability (α=0.89) and correlation with other evaluation scales. The COS-5 may be useful, with the following advantages: it can be performed within a shorter time frame; it facilitates the maintenance of observation quality; it facilitates sharing information with other professions; and it is reliable to identify the autistic features of 5-year-old children. In order to verify its wider applications including the screening of infants (18months to 3years old) by adjusting the items of younger age, additional study is needed.

  9. [Variations in tooth decay rates among children 5 and 12 years old in Minas Gerais, Brazil].

    PubMed

    Lucas, Simone Dutra; Portela, Margareth Crisóstomo; Mendonça, Lisette Lobato

    2005-01-01

    The aim of this ecological study was to analyze to what extent World Health Organization goals were met in relation to dental caries in 2000 in Minas Gerais State, Brazil, identifying factors associated with variation in DMFT and the occurrence of DMFT < or = 3 among 12-year-old children and in the percentage of caries-free 5-year-olds. Secondary data from different sources were used. Linear regression and multiple logistic regression techniques were applied to the analysis of the numerical and dichotomous dependent variables. Socioeconomic and dental services supply/utilization indicators were used as potential explanatory variables. The goals expressed by DMFT < or = 3 at 12 years and a minimum of 50% caries-free 5-year-olds were met by 37% and 9% of the State's municipalities, respectively. In general the dependent variables were associated with socioeconomic level, and no associations were identified with dental care. The results should not be generalized, but they do suggest inequities in oral health and the role played by socioeconomic factors and water fluoridation.

  10. Contrastive voicing acquisition in 2-year-old children: Preliminary data

    NASA Astrophysics Data System (ADS)

    Hitchcock, Elaine R.; Koenig, Laura L.

    2004-05-01

    Earlier studies using voice-onset time (VOT) as the acoustic marker of contrastive voicing acquisition in English have differed widely in method and statistical procedures. Research in this area has shown three primary patterns of voicing acquisition for English stop consonants. One report indicates children demonstrate discrete voicing categories with adult-like VOT values as early as 2 years old. Other reports suggest a subperceptual distinction of the voicing contrast, followed by an exaggerated voicing contrast with evidence of more adult-like discrete categories by 3 years old. Still other reports suggest no distinction between the voicing categories until approximately 3 years. This work investigates voicing acquisition in three typically developing, English-speaking 2-year-old children. The subjects were recorded every 2 weeks for 4-6 months. Approximately 15-20 tokens were elicited for four target utterances containing initial /b p t d/. Frequency distribution, measures of central tendency, and skewness will be calculated for every recording session of each child. Discussion will focus on the development of contrastive VOT categories and their stability over time. These data will contribute to our understanding of laryngeal timing for English stop consonants in young children.

  11. Coronary artery occlusion after arterial switch operation in an asymptomatic 15-year-old boy

    PubMed Central

    Saini, Ashish P; Cyran, Stephen E; Ettinger, Steven M; Pauliks, Linda B

    2016-01-01

    A 15-year-old boy with transposition of the great arteries (TGA) and neonatal arterial switch operation (ASO) presented with complete occlusion of the left main coronary artery (LMCA). Intra-operatively, an intramural left coronary artery was identified. Therefore, since age 7 years he had a series of screening exercise stress tests. At 13 years old, he had 3 to 4 mm ST segment depression in the infero-lateral leads without symptoms. This progressed to 4.2 mm inferior ST segment depression at 15 years old with normal stress echocardiogram. Sestamibi myocardial perfusion scan and cardiac magnetic resonance imaging was inconclusive. Therefore, a coronary angiogram was obtained which showed complete occlusion of the LMCA with ample collateralization from the right coronary artery system. This was later confirmed on a computed tomogram (CT) angiogram, obtained in preparation of coronary artery bypass grafting. The case illustrates the difficulty of detecting coronary artery stenosis and occlusion in young patients with rich collateralization. Coronary CT angiogram and conventional angiography were the best imaging modalities to detect coronary anomalies in this adolescent with surgically corrected TGA. Screening CT angiography may be warranted for TGA patients, particularly for those with known coronary anomalies. PMID:27574609

  12. Prevalence of malocclusion traits and sucking habits among 3-year-old children.

    PubMed

    Dimberg, Lillemor; Bondemark, Lars; Söderfeldt, Björn; Lennartsson, Bertil

    2010-01-01

    The aim of the present study was to evaluate the prevalence of malocclusion traits and sucking habits among 3-year-old children. A sample of 457 3-year-old children (234 girls and 223 boys) was obtained from three Public Dental Health clinics in Orebro County Council, Sweden. Data from clinical examination and a questionnaire were used to determine malocclusion traits, sucking habits, snoring and breathing pattern including nocturnal breathing disturbances. The results showed that 70% had one or more malocclusion traits at 3 years of age. The most common malocclusion traits were anterior open bite (50%), Class II occlusion (26%), increased overjet (23%) and posterior crossbite (19%). The prevalence of sucking habit was 66% and dummy sucking was dominating and in connection with more malocclusion traits than finger/thumb sucking. A significant association was found between the sucking habits and the most prevalent malocclusions, anterior open bite, Class II occlusion, increased overjet and posterior crossbite. In conclusion, the prevalence of malocclusion traits in 3-year-old children was high. Sucking habits was highly prevalent and dummy sucking resulted in more malocclusion traits than finger/thumb sucking did.

  13. Fathers' Depression Related to Positive and Negative Parenting Behaviors With 1-Year-Old Children

    PubMed Central

    Davis, Matthew M.; Freed, Gary L.; Clark, Sarah J.

    2011-01-01

    OBJECTIVE: To examine the associations between depression in fathers of 1-year-old children and specific positive and negative parenting behaviors discussed by pediatric providers at well-child visits. METHODS: We performed a cross-sectional secondary analysis by using interview data from 1746 fathers of 1-year-old children in the Fragile Families and Child Wellbeing Study. Positive parenting behaviors included fathers' reports of playing games, singing songs, and reading stories to their children ≥3 days in a typical week. Negative parenting behavior included fathers' reports of spanking their 1-year-old children in the previous month. Depression was assessed by using the World Health Organization Composite International Diagnostic Interview Short Form. Weighted bivariate and multivariate analyses of parenting behaviors were performed while controlling for demographics and paternal substance abuse. RESULTS: Overall, 7% of fathers had depression. In bivariate analyses, depressed fathers were more likely than nondepressed fathers to report spanking their 1-year-old children in the previous month (41% compared with 13%; P < .01). In multivariate analyses, depressed fathers were less likely to report reading to their children ≥3 days in a typical week (adjusted odds ratio: 0.38 [95% confidence interval: 0.15–0.98]) and much more likely to report spanking (adjusted odds ratio: 3.92 [95% confidence interval: 1.23–12.5]). Seventy-seven percent of depressed fathers reported talking to their children's doctor in the previous year. CONCLUSIONS: Paternal depression is associated with parenting behaviors relevant to well-child visits. Pediatric providers should consider screening fathers for depression, discussing specific parenting behaviors (eg, reading to children and appropriate discipline), and referring for treatment if appropriate. PMID:21402627

  14. The development of categorical perception of Mandarin tones in four- to seven-year-old children.

    PubMed

    Chen, Fei; Peng, Gang; Yan, Nan; Wang, Lan

    2016-12-05

    To track the course of development in children's fine-grained perception of Mandarin tones, the present study explored how categorical perception (CP) of Mandarin tones emerges along age among 70 four- to seven-year-old children and 16 adults. Prominent discrimination peaks were found for both the child and the adult groups, and they were well aligned with the corresponding identification crossovers. Moreover, six-year-olds showed a much narrower width (i.e. a sharper slope) compared to younger children, and have already acquired adult-like identification competence of Mandarin high-level and mid-rising tones. Although the ability to discriminate within-category tone pairs did not change, the between-category discrimination accuracies were positively correlated with chronological ages among child participants. We assume that the perceptual refinement of Mandarin tones in young children may be driven by an accumulation of perceptual development from the tonal information of the ambient sound input.

  15. [Association between Crohn's disease and primary sclerosing cholangitis in a 10 year old girl].

    PubMed

    Muñoz Lozón, Ana; Iglesias Blázquez, Cristina; Menéndez Arias, Cristina; Domínguez Sánchez, Patricia

    2016-06-01

    A 10 year old girl with diarrhea, abdominal pain, weight loss and fever of one month and a half of evolution. Analytical and sonographic findings raised the possibility of inflammatory bowel disease. Endoscopy and histology showed findings consistent with Crohn's disease. Treatment was initiated with mesalazine and exclusive enteral nutrition. Later corticosteroid treatment, immunosuppressive drugs and ursodeoxycholic acid were added due to cholestasis and persistent hypergammaglobulinemia. Magnetic resonance cholangiography and liver biopsy confirmed the diagnosis of concomitant primary sclerosing cholangitis. The association between Crohn's disease and primary sclerosing cholangitis is rare, predominantly in males between 20 and 40 years old and it presents a great clinical variability. The confirmation of the diagnosis requires magnetic resonance cholangiography or endoscopic retrograde cholangiopancreatography. The prognosis is poor and there is no treatment to slow the progression of the disease.

  16. Response conflict processes' classification in 7 and 9 year old children using EEG brain connectivity measures.

    PubMed

    Almabruk, T; Iyer, K; Girdler, S; Khan, M M; Tan, T

    2016-08-01

    Investigating cognitive development of children poses interesting challenges pertaining to emergence of children's' ability to think and understand. Psychological tasks that involve conflict, like the Flanker task, are widely used to understand development of response conflict processes. In this study, EEG signals were used to examine the coherence and imaginary part of coherency within the delta, theta, alpha and beta bands across different conditions of the Flanker task. Longitudinal data were collected from a group of typically developing children at ages of seven and nine. We found that the imaginary part of coherency was more helpful in distinguishing between stimuli - alpha and beta bands resulted in 90.90% classification rate in seven year old children. The beta and theta bands were found to be more effective for stimuli classification in nine year old children - more than 84.09% classification accuracy was achieved.

  17. Arthroscopic excision of acetabular osteoid osteoma in a 7-year-old patient.

    PubMed

    Aşık, Mehmet; Erşen, Ali; Polat, Gökhan; Bilgili, Fuat; Tunalı, Onur

    2015-11-01

    The purpose of this study was to present the case report of a 7-year-old patient who was treated with hip arthroscopy for an acetabular osteoid osteoma. A 7-year-old patient was referred to our clinic with hip pain. In the assessment of the patient, an acetabular osteoid osteoma was detected in his right hip; it was adjacent to his triradiate cartilage. An arthroscopic surgery was planned as an alternative to open safe hip dislocation. The osteoid osteoma was completely removed with hip arthroscopy. Postoperative CT scanning and histopathological analysis confirmed the diagnosis. Exposure of the acetabulum can be problematic in paediatric patients due to the potential risks of open safe dislocation. Hip arthroscopy can safely be used for benign hip lesions in paediatric patients. Level of evidence Case report, Level V.

  18. Phonological development in 4-6-year-old moderately hearing impaired children.

    PubMed

    Huttunen, K H

    2001-01-01

    The acquisition of clear phonological rules is of utmost importance for a child when he/she is learning to decode and convey meanings using spoken language. Fifteen Finnish-speaking children, five normally hearing (NH) 3-year-olds and 10 moderately hearing impaired (HId) 4-6-year-olds were studied here. Speech samples consisting of 62 words were collected from each child during a picture naming task. Frequent phonetic (articulation) errors together with normal (but delayed) and deviant phonological processes of HId children were found in this study. The frequency and quality of the processes seemed to be related more to the grade of HI than, for example, the age of the child. Implications for speech therapy are briefly discussed.

  19. A rare case of gallbladder fistulation with a 60-year-old appendicectomy scar.

    PubMed

    Thiruchandran, Gajendiran; Joyce, Megan; Baggott, Paul James

    2016-04-12

    We present an extremely unusual case of an external biliary fistula in an 87-year-old woman who presented with a 1-day history of spontaneous green discharge from a 60-year-old appendicectomy scar. Examination revealed a sinus in the right iliac fossa overlying her appendicectomy scar, with a raised white cell count and C reactive protein. A CT scan revealed a complex fistula connecting the gallbladder to the subcutaneous tissue in the right flank, which further connected inferiorly with a fistula to the previous appendicectomy scar and a small iliopsoas collection. Endoscopic retrograde cholangiopancreatography revealed several stones in the common bile duct, which were removed using a balloon catheter. The patient was further managed with a long course of antibiotics and discharged with a long-term drainage bag. A literature search revealed no previously reported cases of an external biliary fistula communicating with an appendicectomy scar.

  20. Gesture and Symbolic Representation in Italian and English-Speaking Canadian 2-Year-Olds.

    PubMed

    Marentette, Paula; Pettenati, Paola; Bello, Arianna; Volterra, Virginia

    2016-05-01

    Analyses of elicited pantomime, primarily of English-speaking children, show that preschool-aged children are more likely to symbolically represent an object with gestures depicting an object's form rather than its function. In contrast, anecdotal reports of spontaneous gesture production in younger children suggest that children use multiple representational techniques. This study examined the spontaneous gestures of sixty-four 2-year-old Italian children and English-speaking Canadian children, primarily from middle-class Caucasian families. The Italian children produced twice as many gestures as Canadian children in a picture-naming task but produced a similar range of representational techniques. Two-year-olds were equally likely to produce gestures depicting function as form. These data suggest young children's communicative skills are supported by a symbolic capacity that reflects contextual communicative demands.