Science.gov

Sample records for 16-week treatment period

  1. Neural changes associated with appetite information processing in schizophrenic patients after 16 weeks of olanzapine treatment

    PubMed Central

    Stip, E; Lungu, O V; Anselmo, K; Letourneau, G; Mendrek, A; Stip, B; Lipp, O; Lalonde, P; Bentaleb, L A

    2012-01-01

    There is evidence that some atypical antipsychotics, including olanzapine, can produce unwanted metabolic side effects, weight gain and diabetes. However, neuronal correlates of change related to food information processing have not been investigated with these medications. We studied the effect of a pharmacological manipulation with an antipsychotic known to cause weight gain on metabolites, cognitive tasks and neural correlates related to food regulation. We used functional magnetic resonance imaging in conjunction with a task requiring visual processing of appetitive stimuli in schizophrenic patients and healthy controls before and after 16 weeks of antipsychotic medication with olanzapine. In patients, the psychological and neuronal changes associated following the treatment correlated with appetite control measures and metabolite levels in fasting blood samples. After 16 weeks of olanzapine treatment, the patients gained weight, increased their waist circumference, had fewer positive schizophrenia symptoms, a reduced ghrelin plasma concentration and an increased concentration of triglycerides, insulin and leptin. In premotor area, somatosensory cortices as well as bilaterally in the fusiform gyri, the olanzapine treatment increased the neural activity related to appetitive information in schizophrenic patients to similar levels relative to healthy individuals. However, a higher increase in sensitivity to appetitive stimuli after the treatment was observed in insular cortices, amygdala and cerebellum in schizophrenic patients as compared with healthy controls. Furthermore, these changes in neuronal activity correlated with changes in some metabolites and cognitive measurements related to appetite regulation. PMID:22714121

  2. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.

    PubMed

    Kasemsuk, Thitima; Saengpetch, Nadhaporn; Sibmooh, Nathawut; Unchern, Supeenun

    2016-10-01

    Treatment with bromelain-containing enzyme preparation for 3-4 weeks is effective for treatment of knee osteoarthritis (OA). Here, we aimed to assess 16-week treatment with bromelain in mild-to-moderate knee OA patients. We performed a randomized, single-blind, active-controlled pilot study. Forty knee OA patients were randomized to receive oral bromelain (500 mg/day) or diclofenac (100 mg/day). Primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) analyzed by Wilcoxon signed rank test. Secondary outcome was the short-form 36 (SF-36). Plasma malondialdehyde (MDA) and nitrite were measured as oxidative stress markers. There was no difference in WOMAC and SF-36 scores compared between bromelain and diclofenac groups after 4 weeks. At week 4, the improvement of total WOMAC and pain subscales from baseline was observed in both groups; however, two patients given diclofenac had adverse effects leading to discontinuation of diclofenac. However, observed treatment difference was inconclusive. At week 16 of bromelain treatment, the patients had improved total WOMAC scores (12.2 versus 25.5), pain subscales (2.4 versus 5.6), stiffness subscales (0.8 versus 2.0), and function subscales (9.1 versus 17.9), and physical component of SF-36 (73.3 versus 65.4) as compared with baseline values. OA patients had higher plasma MDA, nitrite, and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-stimulated whole blood but lower plasma α-tocopherol than control subjects. Plasma MDA and LPS-stimulated PGE2 production were decreased at week 16 of bromelain treatment. Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.

  3. Changes in Respiratory Parameters and Fin-Swimming Performance Following a 16-Week Training Period with Intermittent Breath Holding.

    PubMed

    Stavrou, Vasileios; Toubekis, Argyris G; Karetsi, Eleni

    2015-12-22

    The purpose of this study was to examine the effects of training with intermittent breath holding (IBH) on respiratory parameters, arterial oxygen saturation (SpO2) and performance. Twenty-eight fin-swimming athletes were randomly divided into two groups and followed the same training for 16 weeks. About 40% of the distance of each session was performed with self-selected breathing frequency (SBF group) or IBH (IBH group). Performance time of 50 and 400 m at maximum intensity was recorded and forced expired volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and SpO2 were measured before and after the 50 m test at baseline and post-training. Post-training, the respiratory parameters were increased in the IBH but remained unchanged in the SBF group (FEV1: 17 ±15% vs. -1 ±11%; FVC: 22 ±13% vs. 1 ±10%; PEF: 9 ±14% vs. -4 ±15%; p<0.05). Pre compared to post-training SpO2 was unchanged at baseline and decreased post-training following the 50 m test in both groups (p<0.05). The reduction was higher in the IBH compared to the SBF group (p<0.05). Performance in the 50 and 400 m tests improved in both groups, however, the improvement was greater in the IBH compared to the SBF group in both 50 and 400 m tests (p<0.05). The use of IBH is likely to enhance the load on the respiratory muscles, thus, contributing to improvement of the respiratory parameters. Decreased SpO2 after IBH is likely due to adaptation to hypoventilation. IBH favours performance improvement at 50 and 400 m fin-swimming. PMID:26839609

  4. Changes in Respiratory Parameters and Fin-Swimming Performance Following a 16-Week Training Period with Intermittent Breath Holding

    PubMed Central

    Stavrou, Vasileios; Toubekis, Argyris G.; Karetsi, Eleni

    2015-01-01

    The purpose of this study was to examine the effects of training with intermittent breath holding (IBH) on respiratory parameters, arterial oxygen saturation (SpO2) and performance. Twenty-eight fin-swimming athletes were randomly divided into two groups and followed the same training for 16 weeks. About 40% of the distance of each session was performed with self-selected breathing frequency (SBF group) or IBH (IBH group). Performance time of 50 and 400 m at maximum intensity was recorded and forced expired volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and SpO2 were measured before and after the 50 m test at baseline and post-training. Post-training, the respiratory parameters were increased in the IBH but remained unchanged in the SBF group (FEV1: 17 ±15% vs. −1 ±11%; FVC: 22 ±13% vs. 1 ±10%; PEF: 9 ±14% vs. −4 ±15%; p<0.05). Pre compared to post-training SpO2 was unchanged at baseline and decreased post-training following the 50 m test in both groups (p<0.05). The reduction was higher in the IBH compared to the SBF group (p<0.05). Performance in the 50 and 400 m tests improved in both groups, however, the improvement was greater in the IBH compared to the SBF group in both 50 and 400 m tests (p<0.05). The use of IBH is likely to enhance the load on the respiratory muscles, thus, contributing to improvement of the respiratory parameters. Decreased SpO2 after IBH is likely due to adaptation to hypoventilation. IBH favours performance improvement at 50 and 400 m fin-swimming. PMID:26839609

  5. Changes in Respiratory Parameters and Fin-Swimming Performance Following a 16-Week Training Period with Intermittent Breath Holding.

    PubMed

    Stavrou, Vasileios; Toubekis, Argyris G; Karetsi, Eleni

    2015-12-22

    The purpose of this study was to examine the effects of training with intermittent breath holding (IBH) on respiratory parameters, arterial oxygen saturation (SpO2) and performance. Twenty-eight fin-swimming athletes were randomly divided into two groups and followed the same training for 16 weeks. About 40% of the distance of each session was performed with self-selected breathing frequency (SBF group) or IBH (IBH group). Performance time of 50 and 400 m at maximum intensity was recorded and forced expired volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and SpO2 were measured before and after the 50 m test at baseline and post-training. Post-training, the respiratory parameters were increased in the IBH but remained unchanged in the SBF group (FEV1: 17 ±15% vs. -1 ±11%; FVC: 22 ±13% vs. 1 ±10%; PEF: 9 ±14% vs. -4 ±15%; p<0.05). Pre compared to post-training SpO2 was unchanged at baseline and decreased post-training following the 50 m test in both groups (p<0.05). The reduction was higher in the IBH compared to the SBF group (p<0.05). Performance in the 50 and 400 m tests improved in both groups, however, the improvement was greater in the IBH compared to the SBF group in both 50 and 400 m tests (p<0.05). The use of IBH is likely to enhance the load on the respiratory muscles, thus, contributing to improvement of the respiratory parameters. Decreased SpO2 after IBH is likely due to adaptation to hypoventilation. IBH favours performance improvement at 50 and 400 m fin-swimming.

  6. Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading

    PubMed Central

    Garcia-Alcala, Hector; Santos Vichido, Celia Isabel; Islas Macedo, Silverio; Genestier-Tamborero, Christelle Nathalie; Minutti-Palacios, Marissa; Hirales Tamez, Omara; García, Carlos; Ziegler, Dan

    2015-01-01

    Effective treatment of diabetic sensorimotor polyneuropathy remains a challenge. To assess the efficacy and safety of α-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study, in which 45 patients with type 2 diabetes and symptomatic polyneuropathy were initially treated with ALA (600 mg tid) for 4 weeks (phase 1). Subsequently, responders were randomized to receive ALA (600 mg qd; n = 16) or to ALA withdrawal (n = 17) for 16 weeks (phase 2). During phase 1, the Total Symptom Score (TSS) decreased from 8.9 ± 1.8 points to 3.46 ± 2.0 points. During phase 2, TSS improved from 3.7 ± 1.9 points to 2.5 ± 2.5 points in the ALA treated group (p < 0.05) and remained unchanged in the ALA withdrawal group. The use of analgesic rescue medication was higher in the ALA withdrawal group than ALA treated group (p < 0.05). In conclusion, in type 2 diabetic patients with symptomatic polyneuropathy who responded to initial 4-week high-dose (600 mg tid) administration of ALA, subsequent treatment with ALA (600 mg qd) over 16 weeks improved neuropathic symptoms, whereas ALA withdrawal was associated with a higher use of rescue analgesic drugs. This trial is registered with ClinicalTrials.gov Identifier: NCT02439879. PMID:26345602

  7. The use of an acellular dermal regenerative tissue matrix in the treatment of lower extremity wounds: a prospective 16-week pilot study.

    PubMed

    Brigido, Stephen A

    2006-09-01

    A prospective, single-centre, randomized controlled study was performed to evaluate the effectiveness of Graftjacket, a human acellular regenerative tissue matrix as a treatment option for chronic non healing lower extremity wounds. Twenty-eight diabetic patients with full-thickness wounds that had been present for at least 6 weeks were treated with sharp debridement and randomized to a single application of Graftjacket tissue matrix plus mineral oil-soaked fluff compression dressing or to a control treatment of wound gel with gauze dressings. All patients were seen weekly. By week 16, 12 of 14 patients treated with Graftjacket tissue matrix demonstrated complete wound closure compared with 4 of 14 patients in the control group. Patients treated with Graftjacket tissue matrix showed a statistically significant higher percentage of wound healing with respect to wound area, and clinically significant differences in wound depth and wound volume. This comparison is not performed to demonstrate that the application of the Grafjacket is more effective than sharp debridement. This study is done to help assign a role to the use of Graftjacket matrix in lower extremity wound care.

  8. Macronutrients in human milk at 2, 12, and 16 weeks postpartum.

    PubMed

    Ferris, A M; Dotts, M A; Clark, R M; Ezrin, M; Jensen, R G

    1988-06-01

    This study evaluated changes in human milk composition from 2 to 16 weeks postpartum. Milk from 12 mothers was analyzed for lipid (utilizing a modified Folch), lactose (enzymatic hydrolysis), and nitrogen (semi-micro Kjeldahl). Energy was calculated by fractional analysis and bomb calorimetry. All samples were from well-defined subjects, and uniform collection procedures were used. Milk lipid, total nitrogen, and energy content differed significantly from one woman to another. Lipid and energy content increased from 3.98 +/- 1.0 to 5.50 +/- 1.1 gm/100 ml and 68.5 +/- 9.8 to 83.0 +/- 11.1 kcal/100 ml, respectively, and nitrogen content decreased significantly from 0.24 +/- 0.05 to 0.16 +/- 0.02 gm/100 ml from 2 to 16 weeks postpartum. Lactose remained statistically stable, increasing from 6.3 +/- 0.7 to 7.0 +/- 0.7 gm/100 ml. Estimates of energy from fractional analysis of macronutrients produced lower caloric estimates, especially at 2 weeks postpartum. Statistical differences over time and between and among mothers were found at all periods studied; therefore, on the basis of these data, we caution against reliance on single sample values as representative of mature milk either for individuals or for groups.

  9. The effect of 16-week plyometric training on explosive actions in early to mid-puberty elite soccer players.

    PubMed

    Söhnlein, Quirin; Müller, Erich; Stöggl, Thomas L

    2014-08-01

    Plyometric training (PT) programs are widely used to improve explosive actions in soccer players of various ages, although there is debate about optimal training duration and time course of improvement. Twenty-two early to mid-puberty elite soccer players were assigned to a control group (CG, n = 10, regular soccer training) or a plyometric training group (PTG, n = 12, regular soccer training substituted with 2 PT sessions each week). Both groups trained for 16 weeks during the in-season period. Control group performed only tests at baseline and after intervention, whereas PTG performed additional tests after 4, 8, and 12 weeks. During each test, subjects' performances in speed (10 and 30 m; 5 and 20 m), agility, shuttle run, multiple 5 bounds (MB5), and standing long jump (LJ) were recorded. The PTG showed improved performance in 20-m sprint time (-3.2%), agility time (-6.1%), MB5 distance (+11.8%), and LJ distance (+7.3%) (all, p ≤ 0.05) after 16 weeks. All these improvements were higher compared with CG (all, p ≤ 0.05). The time course of improvement in the PT group showed that 20-m sprint time improved after 16 weeks (p = 0.012); agility after 4 (p = 0.047) and 8 weeks (p = 0.004) but stopped after 12 weeks (p = 0.007); MB5 after 8 (p = 0.039), 12 (p = 0.028), and 16 weeks (p < 0.001); and LJ improved after 4 (p = 0.045), 12 (p = 0.008), and 16 weeks (p < 0.001). Plyometric training seems to be an appropriate training tool to enhance some but not all explosive actions. The results indicate that the duration of a PT program is highly dependent on what type of explosive actions should be improved, or whether several explosive actions should be improved at the same time.

  10. The effect of 16-week plyometric training on explosive actions in early to mid-puberty elite soccer players.

    PubMed

    Söhnlein, Quirin; Müller, Erich; Stöggl, Thomas L

    2014-08-01

    Plyometric training (PT) programs are widely used to improve explosive actions in soccer players of various ages, although there is debate about optimal training duration and time course of improvement. Twenty-two early to mid-puberty elite soccer players were assigned to a control group (CG, n = 10, regular soccer training) or a plyometric training group (PTG, n = 12, regular soccer training substituted with 2 PT sessions each week). Both groups trained for 16 weeks during the in-season period. Control group performed only tests at baseline and after intervention, whereas PTG performed additional tests after 4, 8, and 12 weeks. During each test, subjects' performances in speed (10 and 30 m; 5 and 20 m), agility, shuttle run, multiple 5 bounds (MB5), and standing long jump (LJ) were recorded. The PTG showed improved performance in 20-m sprint time (-3.2%), agility time (-6.1%), MB5 distance (+11.8%), and LJ distance (+7.3%) (all, p ≤ 0.05) after 16 weeks. All these improvements were higher compared with CG (all, p ≤ 0.05). The time course of improvement in the PT group showed that 20-m sprint time improved after 16 weeks (p = 0.012); agility after 4 (p = 0.047) and 8 weeks (p = 0.004) but stopped after 12 weeks (p = 0.007); MB5 after 8 (p = 0.039), 12 (p = 0.028), and 16 weeks (p < 0.001); and LJ improved after 4 (p = 0.045), 12 (p = 0.008), and 16 weeks (p < 0.001). Plyometric training seems to be an appropriate training tool to enhance some but not all explosive actions. The results indicate that the duration of a PT program is highly dependent on what type of explosive actions should be improved, or whether several explosive actions should be improved at the same time. PMID:24476783

  11. Time Course of Recovery Showing Initial Prefrontal Cortex Changes at 16 weeks, Extended to Subcortical Changes by Three years in Pediatric Bipolar Disorder

    PubMed Central

    Yang, Hongyu; Lu, Lisa H.; Wu, Minjie; Stevens, Michael; Wegbreit, Ezra; Fitzgerald, Jacklynn; Levitan, Bryn; Shankman, Stewart; Pavuluri, Mani N.

    2013-01-01

    Objective Developmental changes at the interface of affective and cognitive systems are examined over a three year period in pediatric bipolar disorder (PBD). Methods Thirteen participants with PBD and 10 healthy controls (HC) matched on demographics and IQ were scanned at baseline, 16 weeks, and after three years. All patients received pharmacotherapy based on a medication algorithm. A pediatric affective color matching paradigm was used to probe cognitive processing under emotional challenge. Results Behavioral data illustrated that patients in PBD group were slower in response time at baseline, but normalized by three years. On fMRI analyses at baseline, in response to emotional vs. neutral words, patients with PBD showed greater activation, relative to HC, in the right dorsal lateral prefrontal cortex (DLPFC) and amygdala, ventral lateral prefrontal cortex (VLPFC), bilateral anterior cingulate cortex (ACC), and ventral striatum. The increased activation in cortical areas in the PBD group normalized with no differences from HC by 16 weeks. By three years, normalization was observed in not only the cortical, but also the subcortical regions such as amygdala and striatum. Limitations These preliminary findings need to be replicated with a larger sample, although it can be challenging to obtain large samples for longitudinal studies. Conclusions Greater activation in fronto-striatal and fronto-limbic circuits were observed in unmedicated patients with PBD. With systematic pharmacotherapy for patients with PBD, the time course of recovery was characterized by initial prefrontal changes at 16 weeks, which extended to subcortical normalization at three years. These preliminary findings illustrated that, following appropriate treatment coupled with normal brain development, patients with PBD showed normalization in brain function. PMID:23517886

  12. Effect of a 16-Week Yoga Program on Blood Pressure in Healthy College Students

    ERIC Educational Resources Information Center

    Nelson, Debra; Reed, Justy; Buck, Sarah M.

    2014-01-01

    The purpose of this study was to examine the effect of a 16-week yoga program on blood pressure (BP) in healthy college students. Twenty-five students (Mage = 28.24, SD = 10.64) participated in yoga class twice per week for 16 weeks. Thirty-one students (Mage = 28.77, SD = 7.23) attended a lecture (control condition) at approximately the same time…

  13. Changes in the lipids of human milk from 2 to 16 weeks postpartum.

    PubMed

    Clark, R M; Ferris, A M; Fey, M; Brown, P B; Hundrieser, K E; Jensen, R G

    1982-01-01

    Changes in total lipid, fatty acids, total cholesterol, free cholesterol, and lipid phosphorus in mature milk with time were investigated. Milk samples were collected from 10 mothers at 2, 6, 12, and 16 weeks postpartum. During 1 day, each mother donated two complete breast expressions. Expressions were taken using an electric breast pump 1 h after the previous a.m. and p.m. nursing. For each mother, the a.m. and p.m. samples were pooled for analysis. It was observed that the amount of total lipid increased significantly (p less than 0.05) from 3.9 g/100 ml at 2 weeks to 5.2 g/100 at 16 weeks postpartum. The total fatty acid composition remained uniform during the investigation. Average total cholesterol and free cholesterol in the milk were 10.3 mg/100 ml and 8.3 mg/100 ml, respectively. These concentrations did not change significantly with time postpartum. Average lipid phosphorus was 3.9 mg/100 ml and also remained constant throughout. We conclude that the fatty acid pattern, lipid phosphorus, total cholesterol, and free cholesterol of mature milk to 16 weeks postpartum remains relatively constant while total lipid concentration increases.

  14. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy

    PubMed Central

    Sherman, Ross A.; Crawley, William R.; Cosio-Lima, Ludmila M.

    2016-01-01

    Abstract Crawley, AA, Sherman, RA, Crawley, WR, and Cosio-Lima, LM. Physical fitness of police academy cadets: baseline characteristics and changes during a 16-week academy. J Strength Cond Res 30(5): 1416–1424, 2016—Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk−1, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8–16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  15. Physical Fitness of Police Academy Cadets: Baseline Characteristics and Changes During a 16-Week Academy.

    PubMed

    Crawley, Amy A; Sherman, Ross A; Crawley, William R; Cosio-Lima, Ludmila M

    2016-05-01

    Police academies traditionally emphasize the importance of being physically fit. The purpose of this research was to determine cadet baseline physical fitness characteristics and assess effectiveness of a 16-week training program. Sixty-eight cadets (61 men, 7 women) volunteered to have baseline physical fitness characteristics assessed, and 55 cadets (49 men, 6 women) completed further testing at weeks 8 and 16. The testing comprised hand grip (strength), arm crank (upper-body power), 30 seconds Wingate (lower body power), sum of skinfolds and percentage body fat (body composition), 40-yard dash (sprint speed), 1 repetition maximum bench press (strength), T-test (agility), and sit-and-reach (flexibility). In addition, cadets completed standardized state testing (push-ups, sit-ups, vertical jump, and half-mile shuttle run). The training program consisted of 1 hour sessions, 3 d·wk, including aerobic, plyometrics, body weight, and resistance exercise. Significant changes were found in agility (p < 0.01), upper-body and lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05) across the first 8 weeks, and in agility (p ≤ 0.05), lower-body peak power (p ≤ 0.05), sit-ups (p < 0.01), push-ups (p ≤ 0.05), half-mile shuttle run (p < 0.01) across the full 16 weeks. However, none of the variables showed significant change across the second half of the program (weeks 8-16). A number of individual parameters of physical fitness showed evidence of improvement in the first 8 weeks, whereas none of the variables showed significant improvement in the second 8 weeks. This suggests modifications could be made to increase overall effectiveness of cadet physical training specifically after the 8-week mark. PMID:26466133

  16. Diurnal patterns of salivary alpha-amylase and cortisol secretion in female adolescent tennis players after 16 weeks of training.

    PubMed

    Filaire, Edith; Ferreira, Jose Pedro; Oliveira, Miguel; Massart, Alain

    2013-07-01

    We examined the effects of 16 weeks of training on diurnal pattern of salivary alpha-amylase (sAA), cortisol, and the ratio of sAA over cortisol (AOC) in 12 national adolescent female tennis players. Stress and recovery were also evaluated using the Recovery-Stress-Questionnaire for Athletes-RESTQ-Sport. Data were collected after a 2-week rest (January, W0), and 4 months after W0 (W16). Subjects collected five saliva samples throughout a day. While all participants displayed the previously shown decrease after awakening in adolescents at W0, they showed a rise in the alpha-amylase awakening response and a higher alpha-amylase activity output (p<0.01) at W16 compared to W0. For the daily rhythm of cortisol we found subjects having a low overall output of salivary cortisol (p<0.01) and a blunted response to awakening at W16. Furthermore, an increase in the ratio AOC at W16, and a negative correlation between this ratio and Sport-specific recovery score. Our findings offer support for the hypothesis that increase of training load during the study period induced asymmetry activation between the two stress systems, in relation to psychological alterations and performance decrease. These results provide encouragement to continue exploring the impact of training program using a psychobiological approach among young athletes in order to prevent fatigue and preserve the health of these athletes.

  17. Effect of a 16-week Pilates exercise program on the ego resiliency and depression in elderly women

    PubMed Central

    Roh, Su Yeon

    2016-01-01

    This study aims to examine the effect of a 16-week Pilates exercise program on the ego resiliency and depression in elderly women. Before participating in Pilates exercise programs, researcher explained the purpose and the intention of the research to elderly women who were willing to participate in this research. A total of 148 elderly women agreed to participate in the program and they filled in ego resiliency and depression questionnaires. Then, the elderly participated in the 16-week Pilates exercise program and completed the same questionnaires afterwards. Collected data was analyzed by the SPSS ver. 20.0 program and results of paired t-test were as follows; there were statistically significant differences in all subvariables of the ego resiliency such as self-confidence (t=7.770, P<0.001), communication efficiency (t=2.690, P<0.01), optimistic trait (t=1.996, P<0.05), and anger management (t=4.525, P<0.001) after elderly women participated in the 16-week Pilates exercise program, there was a statistically significant difference in depression of elderly women who participated in the 16-week Pilates exercise program (t=−6.506, P<0.001) which was statistically lower than before their participation in the program. Consequently, participating in the Pilates exercise program can help improve the ego-resiliency and alleviate depression of the elderly women. PMID:27807531

  18. Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial.

    PubMed

    Choi, Jae-Suk; Park, Jae Beom; Moon, Woi-Sook; Moon, Jin-Nam; Son, Sang Wook; Kim, Mi-Ryung

    2015-01-01

    We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope(®). Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals. PMID:26632177

  19. Use of the Fitbit to Measure Adherence to a Physical Activity Intervention Among Overweight or Obese, Postmenopausal Women: Self-Monitoring Trajectory During 16 Weeks

    PubMed Central

    Marcus, Bess H; Patterson, Ruth E; Parker, Barbara A; Morey, Brittany L

    2015-01-01

    Background Direct-to-consumer trackers and devices have potential to enhance theory-based physical activity interventions by offering a simple and pleasant way to help participants self-monitor their behavior. A secondary benefit of these devices is the opportunity for investigators to objectively track adherence to physical activity goals across weeks or even months, rather than relying on self-report or a small number of accelerometry wear periods. The use of consumer trackers for continuous monitoring of adherence has considerable potential to enhance physical activity research, but few studies have been published in this rapidly developing area. Objective The objective of the study was to assess the trajectory of physical activity adherence across a 16-week self-monitoring intervention, as measured by the Fitbit tracker. Methods Participants were 25 overweight or obese, postmenopausal women enrolled in the intervention arm of a randomized controlled physical activity intervention trial. Each participant received a 16-week technology-based intervention that used the Fitbit physical activity tracker and website. The overall study goal was 150 minutes/week of moderate to vigorous intensity physical activity (MVPA) and 10,000 steps/day; however, goals were set individually for each participant and updated at Week 4 based on progress. Adherence data were collected by the Fitbit and aggregated by Fitabase. Participants also wore an ActiGraph GT3X+ accelerometer for 7 days prior to the intervention and again during Week 16. Results The median participant logged 10 hours or more/day of Fitbit wear on 95% of the 112 intervention days, with no significant decline in wear over the study period. Participants averaged 7540 (SD 2373) steps/day and 82 minutes/week (SD 43) of accumulated “fairly active” and “very active” minutes during the intervention. At Week 4, 80% (20/25) of women chose to maintain/increase their individual MVPA goal and 72% (18/25) of participants

  20. Olanzapine vs. Risperidone in Patients with First-Episode Schizophrenia and a Lifetime History of Cannabis Use Disorders: 16-Week Clinical and Substance Use outcomes

    PubMed Central

    Sevy, Serge; Robinson, Delbert G.; Sunday, Suzanne; Miller, Rachel; McCormack, Joanne; Kane, John M.

    2011-01-01

    The purpose of this study is to compare the efficacy of olanzapine and risperidone for the acute treatment of first-episode schizophrenia patients with cannabis use disorders. This secondary analysis of a previously published study included forty-nine first-episode patients with a diagnosis of schizophrenia, schizophreniform disorder, or schizoaffective disorder and a co-occurring lifetime diagnosis of cannabis use disorders randomly assigned to treatment with either olanzapine (n=28) or risperidone (n=21) for 16 weeks. The olanzapine group did not differ significantly from the risperidone group for initial response rates of positive symptoms, and rates of cannabis use or alcohol use during the study. Positive symptoms and SANS global asociality-anhedonia improved over time but did not differ between study medications. In both groups, cannabis use during the study was higher in patients who used cannabis within 3 months of the admission. Thus, our results suggest that olanzapine and risperidone had a similar initial efficacy on psychotic symptoms and substance use in first-episode patients with co-occurring cannabis use disorders. If clinicians are choosing between olanzapine versus risperidone treatment for this population, their decision should be based upon factors other than symptom response and short-term substance misuse. PMID:21636134

  1. Improved Blood Biomarkers but No Cognitive Effects from 16 Weeks of Multivitamin Supplementation in Healthy Older Adults

    PubMed Central

    Harris, Elizabeth; Macpherson, Helen; Pipingas, Andrew

    2015-01-01

    Supplementation with vitamins, minerals and phytonutrients may be beneficial for cognition, especially in older adults. The aim of this study was to assess the effects of multivitamin supplementation in older adults on cognitive function and associated blood biomarkers. In a randomised, double blind, placebo-controlled trial, healthy women (n = 68) and men (n = 48) aged 55–65 years were supplemented daily for 16 weeks with women’s and men’s formula multivitamin supplements. Assessments at baseline and post-supplementation included computerised cognitive tasks and blood biomarkers relevant to cognitive aging. No cognitive improvements were observed after supplementation with either formula; however, several significant improvements were observed in blood biomarkers including increased levels of vitamins B6 and B12 in women and men; reduced C-reactive protein in women; reduced homocysteine and marginally reduced oxidative stress in men; as well as improvements to the lipid profile in men. In healthy older people, multivitamin supplementation improved a number of blood biomarkers that are relevant to cognition, but these biomarker changes were not accompanied by improved cognitive function. PMID:25996285

  2. Effects of 16-Week Consumption of Caffeinated and Decaffeinated Instant Coffee on Glucose Metabolism in a Randomized Controlled Trial

    PubMed Central

    Ohnaka, Keizo; Ikeda, Mizuko; Maki, Takako; Okada, Tomoko; Shimazoe, Takao; Adachi, Masahiro; Nomura, Masatoshi; Takayanagi, Ryoichi; Kono, Suminori

    2012-01-01

    Objective. Observational studies have shown a protective association between coffee consumption and type 2 diabetes mellitus whereas caffeine or caffeinated coffee acutely deteriorates glucose tolerance. We investigated the effects of chronic drinking of instant coffee on glucose and insulin concentrations during a 75 g oral glucose tolerance test. Methods. Overweight men with a mild-to-moderate elevation of fasting plasma glucose were randomly allocated to a 16-week intervention of consuming 5 cups of caffeinated (n = 17) or decaffeinated (n = 15) instant coffee per day or no coffee (n = 13). Results. The caffeinated coffee group showed statistically significant decreases in the 2-hour concentrations and the area under the curve of glucose while neither decaffeinated coffee nor coffee group showed such a change. Waist circumstance decreased in the caffeinated coffee group, increased in the decaffeinated coffee group, and did not change in the noncoffee group (P = 0.002). With adjustment for the change in waist circumference, caffeinated and decaffeinated coffee consumption were associated with a modest decrease in the postload glucose levels. Conclusion. Both caffeinated and decaffeinated coffee may be protective against deterioration of glucose tolerance. PMID:23193459

  3. Effects of 16-week functional movement screen training program on strength and flexibility of elite high school baseball players.

    PubMed

    Song, Hong-Sun; Woo, Seung-Seok; So, Wi-Young; Kim, Kwang-Jun; Lee, Joohyung; Kim, Joo-Young

    2014-04-01

    Functional Movement Screen (FMS) is a way to pretest functional movement. This study examined the effects of the FMS training program on the strength and flexibility of 62 elite male high school baseball players (31 in the training group, 31 in the control group). All players who received less than two points on each FMS test item had to join the 16-week, three times weekly FMS training program. To analyze results among the FMS participants, measures including intraclass correlation coefficient (ICC) and repeated measure ANOVA were utilized. The Kappa coefficient was 0.805 when the intraclass correlation coefficient of the three participants was inspected. Strength showed a significant interaction depending on time and group (hand grip strength: P=0.011, bench press and squat both for one-repetition maximum (1RM): P=0.001 and P=0.008, respectively). Back muscle strength did not show a significant difference (P=0.660). Trunk forward flexion showed no interaction depending on time and groups (P=0.983) but trunk extension backward showed significant differences depending on groups (P=0.004) and time (P=0.001). Splits showed a significant difference depending on time and groups (P=0.004). The FMS training program improved the strength and flexibility of elite high school baseball players.

  4. Effects of 16-week functional movement screen training program on strength and flexibility of elite high school baseball players

    PubMed Central

    Song, Hong-Sun; Woo, Seung-Seok; So, Wi-Young; Kim, Kwang-Jun; Lee, Joohyung; Kim, Joo-Young

    2014-01-01

    Functional Movement Screen (FMS) is a way to pretest functional movement. This study examined the effects of the FMS training program on the strength and flexibility of 62 elite male high school baseball players (31 in the training group, 31 in the control group). All players who received less than two points on each FMS test item had to join the 16-week, three times weekly FMS training program. To analyze results among the FMS participants, measures including intraclass correlation coefficient (ICC) and repeated measure ANOVA were utilized. The Kappa coefficient was 0.805 when the intraclass correlation coefficient of the three participants was inspected. Strength showed a significant interaction depending on time and group (hand grip strength: P=0.011, bench press and squat both for one-repetition maximum (1RM): P=0.001 and P=0.008, respectively). Back muscle strength did not show a significant difference (P=0.660). Trunk forward flexion showed no interaction depending on time and groups (P=0.983) but trunk extension backward showed significant differences depending on groups (P=0.004) and time (P=0.001). Splits showed a significant difference depending on time and groups (P=0.004). The FMS training program improved the strength and flexibility of elite high school baseball players. PMID:24877049

  5. Optimizing the treatment of mood disorders in the perinatal period.

    PubMed

    Meltzer-Brody, Samantha; Jones, Ian

    2015-06-01

    The perinatal period is a time of high risk for women with unipolar and bipolar mood disorders. We discuss treatment considerations for perinatal mood disorders, including unipolar and bipolar depression as well as postpartum psychosis. We further explore the unique issues faced by women and their families across the full trajectory of the perinatal period from preconception planning through pregnancy and following childbirth. Treatment of perinatal mood disorders requires a collaborative care approach between obstetrics practitioners and mental health providers, to ensure that a thoughtful risk : benefit analysis is conducted. It is vital to consider the risks of the underlying illness versus risks of medication exposure during pregnancy or lactation. When considering medication treatment, attention must be paid to prior medication trials that were most efficacious and best tolerated. Lastly, it is important to assess the impact of individual psychosocial stressors and lifestyle factors on treatment response.

  6. Zebra mussel control using periodic chlorine dioxide treatments. Final report

    SciTech Connect

    Mussalli, Y.G.; Martin, P.D.

    1995-11-01

    Chlorine dioxide was injected into the water intakes at two power plants in Illinois and one in Indiana in an effort to eradicate the existing population of zebra mussels and mitigate further settlement in station river water cooling systems. Results of the treatments at Illinois Power Company`s Wood River Station on the Mississippi River, Central Illinois Public Service`s Meredosia Station on the Illinois River, and SI Energy`s Gallagher Station on the Ohio River are reported. Treatments were performed on a turnkey basis, with three treatments performed at Meredosia Station in 1994, six treatments performed at Wood River Station between July 1993 and September 1994, and 2 treatments performed at Gallagher Station in 1994. For each treatment, a contractor installed and operated a portable chlorine dioxide generator, monitored water quality and oxidant levels, and provided and monitored bioboxes containing test mussels. Results of the treatments were very favorable, indicating a good potential for periodic treatments with chlorine dioxide to control zebra mussel infestations in the raw water systems of power plants and other industrial facilities. Some difficulties with the chlorine dioxide generation system and cold temperature effects reduced the treatment effectiveness, particularly the second treatment at Gallagher Station. Average induced mortalities ranged from 70 to 100% at Wood River, 87 to 92% at Meredosia, and 30 to 100% at Gallagher for native mussels. Dechlorination successfully kept total oxidant residual levels at or below 0.05 ppM during all treatments at all stations.

  7. Treatment delay period: the case of arsenicosis in rural Bangladesh.

    PubMed

    Paul, Bimal Kanti; Brock, Vicki L Tinnon

    2006-12-01

    Arsenic concentrations of tubewell water that exceed acceptable limits poses a serious health problem in Bangladesh. Many Bangladeshis are now suffering from arsenic-related diseases. The objectives of this paper are to examine the extent of delay in seeking medical treatment by victims of arsenic poisoning and to identify factors contributing to this delay. Questionnaire survey successfully administered to 663 victims living in two rural areas of Bangladesh provided the major data source for this study. Analysis of survey data reveal that median delay period was 12 months, but the delay period ranged from 1 month to 18 years. Because of this extremely large range, the mean delay period was about 22 months. The study identified time of identification of symptoms of arsenicosis as the most significant determinant of treatment delay followed by treatment sought from members of mobile medical teams, perceived threat, and level of education. Based on the study findings, it is recommended that the Bangladesh government and NGOs involved in arsenic mitigation and prevention efforts should educate individuals at risk for arsenic poisoning about the benefits of seeking early treatment. This study also recommends to continue to dispatch mobile medical teams to the arsenic-impacted areas.

  8. Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

    PubMed Central

    Osawa, Yusuke; Azuma, Koichiro; Tabata, Shogo; Katsukawa, Fuminori; Ishida, Hiroyuki; Oguma, Yuko; Kawai, Toshihide; Itoh, Hiroshi; Okuda, Shigeo; Matsumoto, Hideo

    2014-01-01

    It is unclear whether combined leg and arm high-intensity interval training (HIIT) improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC) and arm-cranking (AC) ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7) and the other LC- and AC-HIIT (n=5) twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute) peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA) of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%±38%; P<0.05) and the LC–AC groups (11%±9%; P<0.05). The CSA of the quadriceps femoris muscles also increased from baseline in both the LC (11%±4%; P<0.05) and the LC–AC groups (5%±5%; P<0.05). In contrast, increases were observed in the CSA of musculus psoas major (9%±11%) and musculus anterolateral abdominal (7%±4%) only in the LC–AC group. These results suggest that a combined LC- and AC-HIIT program improves aerobic capacity and muscle hypertrophy in both leg and trunk muscles. PMID:25395872

  9. Acute and chronic cardiovascular response to 16 weeks of combined eccentric or traditional resistance and aerobic training in elderly hypertensive women: a randomized controlled trial.

    PubMed

    Dos Santos, Eduardo S; Asano, Ricardo Y; Filho, Irênio G; Lopes, Nilson L; Panelli, Paulo; Nascimento, Dahan da C; Collier, Scott R; Prestes, Jonato

    2014-11-01

    Both aerobic (AT) and resistance training (RT) are recommended as nonpharmacological treatments to prevent hypertension. However, there is a paucity of literature investigating the effects of combined exercise modes (RT combined with AT) in elderly hypertensive women. Thus, our aim was to compare the postexercise hypotension (PEH) response to both protocol models and to assess the correlation between the degree of PEH after acute and chronic training. Furthermore, we also compared several biochemical variables for each training group. Sixty hypertensive older women were randomly assigned into nonexercised control (no systematic exercise training throughout the study), eccentric RT (ERT), and traditional RT (TRT). The training programs consisted of 16 weeks of RT combined with AT. Blood pressure (BP), biochemical profiles, and 1 repetition maximum (1RM) were evaluated. There was a significant increase in high-density lipoprotein (HDL) after both training regimens pre- to posttraining (combined ERT +5% and TRT +7%; p = 0.001 for both). There was a decrease in systolic BP (SBP) (combined ERT -19% and TRT -21%; p = 0.001 for both) and diastolic BP (DBP) (-13% for both; p = 0.001 for both). There was an increase in bench press 1RM (combined ERT +54% and TRT +35%; p = 0.001 for both) and leg press 1RM (combined ERT +52% and TRT +33%; p = 0.001 for both). The magnitude of decrease in SBP after acute exercise was moderately correlated with the drop in SBP after chronic training for the ERT combined with AT group (r = 0.64). Both combined training protocols are effective in promoting benefits in health-related factors (HDL, SBP, DBP, and 1RM). Considering the lower cardiovascular stress experienced during combined ERT, this type of training seems to be the most suitable for elders, deconditioned individuals, and hypertensives. PMID:24845208

  10. Motivation and Its Relationship to Adherence to Self-Monitoring and Weight Loss in a 16-Week Internet Behavioral Weight Loss Intervention

    ERIC Educational Resources Information Center

    Webber, Kelly H.; Tate, Deborah F.; Ward, Dianne S.; Bowling, J. Michael

    2010-01-01

    Objective: To examine changes in motivation and the relationship of motivation to adherence to self-monitoring and weight loss in a 16-week Internet behavioral weight-loss intervention. Design: Two-group randomized design. Setting: This study was conducted over the Internet. Participants: Sixty-six women, ages 22-65, with a body mass index (BMI)…

  11. Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai health workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks

    PubMed Central

    Anekthananon, T.; Pukritayakamee, S.; Ratanasuwan, W.; Jittamala, P.; Werarak, P.; Charunwatthana, P.; Suwanagool, S.; Lawpoolsri, S.; Stepniewska, K.; Sapchookul, P.; Puthavathana, P.; Fukuda, C.; Lindegardh, N.; Tarning, J.; White, N. J.; Day, N.; Taylor, W. R. J.

    2013-01-01

    Objectives Long-term chemoprophylaxis using neuraminidase inhibitors may be needed during influenza epidemics but safety data are limited to several weeks. We sought to assess the tolerability of oseltamivir and zanamivir as primary prophylaxis over 16 weeks. Methods We conducted a parallel group, double blind, 2 (active drug) :1 (placebo) randomized trial of oral oseltamivir/placebo or inhaled zanamivir/placebo over 16 weeks in healthy, Thai hospital professionals at two Bangkok hospitals. The primary endpoint was study withdrawal due to drug-related (possibly, probably, definitely) serious or adverse events (AEs) graded ≥2. Results Recruited subjects numbered 129 oseltamivir/65 placebo and 131 zanamivir/65 placebo. A total of 102 grade ≥2 AEs were reported or detected in 69 subjects: 23/129 (17.8%) versus 15/65 (23.1%) (P = 0.26), and 23/131 (17.6%) versus 8/65 (12.3%) (P = 0.28). Intercurrent infections/fevers [26/102 (25.5%)], abnormal biochemistry [25/102 (24.5%)] and gastrointestinal symptoms [18/102 (17.6%)] were the most frequently reported AEs. There were no drug-related study withdrawals. Eight serious AEs were all due to intercurrent illnesses. Laboratory, lung function and ECG parameters were similar between drugs and placebos. Conclusions Oseltamivir and zanamivir were well tolerated in healthy hospital professionals. Both drugs can be recommended for primary influenza prophylaxis for up to 16 weeks. PMID:23143901

  12. [The effects of 16-weeks pilates mat program on anthropometric variables and body composition in active adult women after a short detraining period].

    PubMed

    Vaquero-Cristóbal, Raquel; Alacid, Fernando; Esparza-Ros, Francisco; Muyor, José M; López-Miñarro, Pedro Ángel

    2015-04-01

    Introducción: Estudios previos han analizado los efectos de la práctica de Pilates mat sobre las variables antropométricas y la composición corporal en poblaciones sedentarias. No existen estudios sobre los beneficios del Pilates en estas varibles tras un corto periodo de desentrenamiento. Objetivo: Determinar el efecto un programa de 16 semanas de Pilates mat sobre las variables antropométricas, la composición coporal y el somatotipo, en mujeres adultas con experiencia previa tras 3 semanas de desentrenamiento. Metodología: A veintiuna mujeres se les realizó una valoración antropométrica completa siguiendo las indicaciones de la ISAK antes y después de un programa de Pilates mat de 16 semanas (2 días a la semana, una hora por día). Todas las mujeres tenían una experiencia previa en la práctica de Pilates mat de entre 1 y 3 años y venían de un proceso de desentrenamiento de 3 semanas (vacaciones de Navidad). Resultados y discusión: Las mujeres mostraron una reducción significativa del peso corporal, el IMC, los pliegues cutáneos individuales del miembro superior (bíceps y tríceps) y el tronco (subescapular, cresta iliaca, supraespinal y abdominal), el sumatorio de 6 y 8 pliegues, la endomorfia y la masa grasa; y un aumento significativo de la masa muscular. El somatotipo medio se clasificó en meso-endomorfo para el pre- (4,91, 4,01, 1,47) y el post-test (4,68, 4,16, 1,69). Ocho mujeres cambiaron su clasificación del somatotipo tras el programa de intervención. Conclusiones: La práctica de Pilates mat durante 16 semanas provocó cambios asociados a una mejora del estado de salud en las variables antropométricas, sobre todo en los pliegues cutáneos que disminuyeron significativamente, la composición corporal (masa grasa y muscular, que disminuyeron y aumentaron, respectivamente) y el somatotipo (una reducción significativa del componente endomórfico) en mujeres con experiencia previa en la práctica de Pilates después de tres semanas de desentrenamiento.

  13. Periodization

    PubMed Central

    Lorenz, Daniel S.; Reiman, Michael P.; Walker, John C.

    2010-01-01

    Background: Clinicians are constantly faced with the challenge of designing training programs for injured and noninjured athletes that maximize healing and optimize performance. Periodization is a concept of systematic progression—that is, resistance training programs that follow predictable patterns of change in training variables. The strength training literature is abundant with studies comparing periodization schemes on uninjured, trained, and untrained athletes. The rehabilitation literature, however, is scarce with information about how to optimally design resistance training programs based on periodization principles for injured athletes. The purpose of this review is to discuss relevant training variables and methods of periodization, as well as periodization program outcomes. A secondary purpose is to provide an anecdotal framework regarding implementation of periodization principles into rehabilitation programs. Evidence Acquisition: A Medline search from 1979 to 2009 was implemented with the keywords periodization, strength training, rehabilitation, endurance, power, hypertrophy, and resistance training with the Boolean term AND in all possible combinations in the English language. Each author also undertook independent hand searching of article references used in this review. Results: Based on the studies researched, periodized strength training regimens demonstrate improved outcomes as compared to nonperiodized programs. Conclusions: Despite the evidence in the strength training literature supporting periodization programs, there is a considerable lack of data in the rehabilitation literature about program design and successful implementation of periodization into rehabilitation programs. PMID:23015982

  14. [Familial gastric cancer: diagnosis, treatment and periodic surveillance].

    PubMed

    Kluijt, Irma; Sijmons, Rolf H; Hoogerbrugge, Nicoline; Vasen, Hans F A; Cats, Anemieke

    2011-01-01

    The only known genetic causes of hereditary diffuse gastric cancer (HDGC) are germline mutations in the CDH1 gene.- CDH1 mutation carriers have a lifetime risk of 70-80% of developing diffuse gastric cancer. As periodic gastric surveillance is of limited value in detecting early stages of HDGC, prophylactic gastrectomy is advised for this patient group. This group is small and little is known about other types of familial gastric cancer. The Dutch Working Group on Hereditary Gastric Cancer has formulated criteria for various aspects of medical care for families and individuals at high risk of developing gastric cancer, including criteria for diagnostics and periodic gastric surveillance. In order to optimize the care and increase the knowledge on hereditary gastric cancer it is important to centralize medical care for these patients.

  15. Treatment of Anxiety and Depression in the Preschool Period

    ERIC Educational Resources Information Center

    Luby, Joan L.

    2013-01-01

    Objective: Empirical studies have established that clinical anxiety and depressive disorders may arise in preschool children as young as 3.0 years. Because empirical studies validating and characterizing these disorders in preschoolers are relatively recent, less work has been done on the development and testing of age-appropriate treatments.…

  16. Chronic Alcohol Treatment in Rats Alters Sleep by Fragmenting Periods of Vigilance Cycling in the Light Period with Extended Wakenings

    PubMed Central

    Mukherjee, Sanjib; Simasko, Steven M.

    2009-01-01

    Studies have shown that disturbed sleep produced by chronic alcohol abuse in humans can predict relapse drinking after periods of abstinence. How alcohol produces disturbed sleep remains unknown. In this study we used a novel analysis of sleep to examine the effects of alcohol on sleep patterns in rats. This analysis separates waking into multiple components and defines a period labeled vigilance cycling (VC) in which the rat rapidly cycles through various vigilance states. These VC episodes are separated by long duration wake periods (LDW). We find that 6 weeks of alcohol (6% in a liquid diet) caused fragmentation of extended VC episodes that normally occur in the light period. However, total daily amounts of slow-wave sleep (SWS) and rapid-eye movement sleep (REMS) remained constant. The daily amount of wake, SWS, and REMS remained constant because the alcohol treated rats increased the amount of VC in the dark period, and the sleep nature of VC in the dark period became more intense. In addition, we observed more wake and less REMS early in the light period in alcohol treated rats. All effects completely reversed by day 16 of alcohol withdrawal. Comparison of the effects of chronic alcohol to acute alcohol exposure demonstrated the effects of chronic alcohol are due to adaptation and not the acute presence of alcohol. The effects of chronic alcohol treatment in rats mimic the effects reported in humans (REMS suppression, difficulty falling asleep, and difficulty remaining asleep). PMID:19014977

  17. Lymphocyte subpopulations in the liver, spleen, intestines, and mesenteric nodes: an immunohistochemical study using human fetuses at 15-16 weeks.

    PubMed

    Hwang, Si Eun; Kim, Ji Hyun; Yu, Hee Chul; Murakami, Gen; Cho, Baik Hwan

    2014-08-01

    The roles of the liver and intestines in lymphocyte differentiation in human fetuses were assessed by immunohistochemical analysis of the thymus, bone marrow, liver, spleen, intestines, and lymph nodes of 15-16 week human fetuses using primary antibodies against IgM, CD3, CD7, CD8, CD10, CD20, CD45RO, HLA-DR, and CD68. The density of immunoreactive lymphocytes was high in the thymus and lymph nodes, but much lower in the bones, liver, spleen, and intestines. The medulla of the thymus contained IgM-positive mature B lymphocytes as well as CD20-positve B lymphocytes. In contrast, CD10-positive immature B lymphocytes were restricted in the cortex. There were no site-dependent differences among axillary, mediastinal, mesenteric, and pelvic lymph nodes. CD68-positive cells were observed at all sites examined. Many HLA-DR-positive round cells were present in the thymus, with fewer in the liver and spleen. The absolute number of lymphocytes was estimated to be ≥10-fold higher in lymph nodes than in liver. Although limited by analysis of only one fetal stage, these findings suggest that mesenteric nodes are likely to be more important than the liver, spleen, and intestines for lymphocyte proliferation and differentiation in human mid-term fetuses.

  18. Zebra mussel control using periodic chlorine dioxide treatments

    SciTech Connect

    Tsou, J.; Coyle, J.; Crone, D.

    1996-08-01

    This paper summarizes the EPRI report (TR-105202) on the same topic as well as presents changes in current thinking on the suitability (applicability) of chlorine dioxide for fouling control. Chlorine dioxide was tested as a zebra mussel biocide at two steam electric generating stations in Illinois and one in Indiana. The purpose of these studies was to determine the efficacy of chlorine dioxide in killing zebra mussels and to develop site specific treatment programs for the three utilities. The Electric Power Research Institute (EPRI) Zebra Mussel Consortium sponsored the testing of this recent use of chlorine dioxide. The raw water system at Central Illinois Public Service`s Meredosia Station, on the Illinois River, received applications of chlorine dioxide in April, July, and September 1994. The raw water system at Illinois Power Company`s Wood River Station, on the Mississippi River, received applications in July 1993, January, April, May, July, and September 1994. The Gallagher Station, on the Ohio River, was treated in July and October 1994. Chlorine dioxide was generated on-site and injected into the water intake structure. Both cooling and service water systems were treated at the facilities. 6 refs., 13 figs.

  19. Treatment with an orthopedic appliance system in relation to treatment intensity and growth periods. A study of initial effects.

    PubMed

    Malmgren, O; Omblus, J; Hägg, U; Pancherz, H

    1987-02-01

    The study comprises an analysis of the effect of treatment with a modified activator combined with a high-pull headgear during a standardized observation period of the initial 6 months of treatment. All patients (24 girls and 32 boys, aged 8.5 to 15 years) had severe skeletal Class II malocclusion. In the first part of the study, the effect of treatment with the appliance both day and night is compared with the effect when it was worn only at night. Only a small and nonsignificant difference was found, but the patients tended to cooperate better if they were instructed to wear the appliance continuously. In the second part of the study, the effect of treatment is related to the somatic maturation of the patients. Longitudinal records of standing height were used to assess whether treatment had been performed before maximal pubertal growth (prepeak period), during maximal pubertal growth (peak period), or after maximal pubertal growth (postpeak period). The skeletal effect was significantly greater in boys treated during the peak period than in those treated during the prepeak period and a similar tendency, although not significant, was found among girls. The number of patients treated during the postpeak period was too small for statistical analysis.

  20. Effect of n-3 polyunsaturated fatty acid supplementation in patients with rheumatoid arthritis: a 16-week randomized, double-blind, placebo-controlled, parallel-design multicenter study in Korea.

    PubMed

    Park, Yongsoon; Lee, AeRi; Shim, Seung-Cheol; Lee, Ji Hyun; Choe, Jung-Yoon; Ahn, Hongyup; Choi, Chan Bum; Sung, Yoon Kyoung; Bae, Sang Cheol

    2013-07-01

    N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and may be useful for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).We examined the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on RA on top of standard anti-inflammatory treatment. Patients with RA were randomized into two groups in a double-blind, placebo-controlled, parallel-design multicenter study. One hundred nine patients received five capsules of either n-3 PUFA (2.090 g of EPA and 1.165 g of DHA) or high-oleic-acid sunflower oil for 16 weeks. Eighty-one patients completed the study, and no adverse effects were reported. Dietary intake did not change significantly during the study. There were significant increases in n-3 PUFA and EPA levels in erythrocytes in the n-3 PUFA group versus the placebo group, but decreases in n-6 PUFA, 18:2n6, 20:4n6 and 18:1n9 levels in the n-3 PUFA group versus the placebo group. N-3 PUFA supplementation had no significant effects on nonsteroidal anti-inflammatory drug (NSAID) requirements, clinical symptoms of RA or the concentration of cytokines, eicosanoids and bone turnover markers. However, n-3 PUFA supplementation significantly decreased NSAID requirements and leukotriene B4 levels in patients who weighed more than 55 kg. Our results suggest that n-3 PUFA supplementation has no significant effect on RA but may decrease the requirement for NSAIDs in Korean patients with RA who weigh more than 55 kg. PMID:23333088

  1. Periodicity in cell dynamics in some mathematical models for the treatment of leukemia

    NASA Astrophysics Data System (ADS)

    Halanay, A.

    2012-11-01

    A model for the evolution of short-term hematopoietic stem cells and of leukocytes in leucemia under periodic treatment is introduced. It consists of a system of periodic delay differential equations and takes into consideration the asymmetric division. A guiding function is used, together with a theorem of Krasnoselskii, to prove the existence of a strictly positive periodic solution and its stability is investigated.

  2. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation

    PubMed Central

    Sparavigna, Adele; Tenconi, Beatrice

    2016-01-01

    Background An injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid (HA) has been developed with characteristics suited for a global improvement of facial esthetics. Objective To evaluate the HA product performance in improving some key facial esthetic features. The study employed clinical scales, subjective evaluations, and facial skin objective measurements. Methods A single Italian site treated 64 female subjects aged 38–60 years, with injections at five predetermined points, on each side of the face, with a 4-week time lapse between the first and the second product administration. Subjects were evaluated after 4, 8, 12, and 16 weeks, using validated clinical scales, subjective evaluation, and objective quantitative outcome measures. Assessment of esthetic results included photographic documentation. Results Both the clinical and subjective assessments, and the majority of objective instrumental parameters indicated an improvement throughout the study and were already significant at week 4 or 8 and were still significant at week 16 (3 months after the second treatment). Minor and temporary local skin reactions were observed in 23% of subjects at the site of the injections, and the global judgment on tolerability was good or excellent, both in the investigators’ opinion and volunteers’ self-evaluation. Conclusion Both subjective and objective improvement of the facial parameters was consistent with the bio-remodeling purpose, and persistent and still statistically significant at the end of the study. The tolerability and safety profile of the product were judged good or excellent both by investigators and volunteers. This study supports the claim for bio-remodeling of these stable hybrid cooperative complexes of low- and high-molecular-weight HA. PMID:27713647

  3. Stochastic extinction of tumor cells due to synchronization effect through time periodic treatment in a tumor-immune interaction model

    NASA Astrophysics Data System (ADS)

    Aisu, Ryota; Horita, Takehiko

    The response to a time periodic treatment of the immunotherapy in a stochastic model of tumor-immune interaction is numerically investigated. Due to the effect of synchronization among the intrinsic oscillation and the treatment, an enhanced extinction of the tumor cells is observed. It suggests that compared with the static treatment, by controlling the period of the treatment, the time periodic treatment could be an effective way of treatment leading to tumor extinction.

  4. Proliferation enhancement of budding yeast and mammalian cells with periodic oxygen radical treatment

    NASA Astrophysics Data System (ADS)

    Mori, Yosuke; Kobayashi, Jun; Murata, Tomiyasu; Hahizume, Hiroshi; Hori, Masaru; Ito, Masafumi

    2015-09-01

    Recently, nonequilibrium atmospheric-pressure plasmas have been intensively studied for biological applications. However, the each effect of species in plasmas to biological tissue has not been clarified yet because various factors exist in the plasmas. Accordingly, we have studied effects of atomic oxygen dose on cell growth such as budding yeast and mouse NIH3T3 fibroblasts of mammalian cells. Both of cells were suspended with PBS, and treated using oxygen radical source. In order to prevent the radicals from reacting with the ambient air, the treatment region was surrounded by a plastic cover and purged with Ar. The proliferative effect of 15 % was observed at the O3Pj dose of around 1 . 0 ×1017 cm-3 in NIH3T3 cells as well as in yeast cells. Moreover, periodic oxygen treatment enhanced the effect in budding yeast cells. The best interval of periodic oxygen radical treatment was around 2 hours, which is almost the same period as that of their cell cycle. With the optimum interval time, we have investigated the effect of the number of the treatments. As the number of treatments increases, the growth rate of budding yeast cells was gradually enhanced and saturated at thrice treatments. This work was partly supported by JSPS KAKENHI Grant Numbers 26286072 and project for promoting Research Center in Meijo University.

  5. PERIODS OF VERTEBRAL COLUMN SENSITIVITY TO BORIC ACID TREATMENT IN CD-1 MICE IN UTERO

    EPA Science Inventory

    Periods of vertebral column sensitivity to boric acid treatment in CD-1 mice in utero.

    Cherrington JW, Chernoff N.

    Department of Toxicology, North Carolina State University, Raleigh, NC 27695, USA. jana_cherrington@hotmail.com

    Boric acid (BA) has many uses as...

  6. Marketing EPSDT to Clients: A Self-Instructional Module for Early Periodic Screening Diagnosis Treatment.

    ERIC Educational Resources Information Center

    Simon, John L.; McArdle, Patricia

    Early and Periodic Screening, Diagnosis and Treatment (EPSDT) is a program of preventive health services available to individuals under 21 years of age who are eligible for Medicaid benefits. As of July 1, 1973, all states operating a Medicaid program were required to provide EPSDT services to all those eligible. The purpose of this module is to…

  7. Lessons learned from muscle fatigue: implications for treatment of patients with hyperkalemic periodic paralysis.

    PubMed

    Renaud, Jean-Marc; Hayward, Lawrence J

    2012-12-01

    Hyperkalemic periodic paralysis (HyperKPP) is a disease characterized by periods of myotonic discharges and paralytic attacks causing weakness, the latter associated with increases in plasma [K(+)]. The myotonic discharge is due to increased Na(+) influx through defective Na(+) channels that triggers generation of several action potentials. The subsequent increase in extracellular K(+) concentration causes excessive membrane depolarization that inactivates Na(+) channels triggering the paralysis. None of the available treatments is fully effective. This paper reviews the capacity of Na(+) K(+)ATPase pumps, KATP and ClC-1 Cl(-) channels in improving membrane excitability during muscle activity and how using these three membrane components we can study future and more effective treatments for HyperKPP patients. The review of current patents related to HyperKPP reinforces the need of novel approaches for the treatment of this channelopathy.

  8. Regeneration of Aqueous Periodate Solutions by Ozone Treatment: A Sustainable Approach for Dialdehyde Cellulose Production.

    PubMed

    Koprivica, Slavica; Siller, Martin; Hosoya, Takashi; Roggenstein, Walter; Rosenau, Thomas; Potthast, Antje

    2016-04-21

    A method for easy and fast regeneration of aqueous periodate solutions from dialdehyde cellulose (DAC) production by ozone treatment is presented, along with a direct and reliable simultaneous quantification of iodate and periodate by reversed-phase HPLC. The influence of iodate and ozone concentration, solution pH, and reaction time on the regeneration efficiency was studied, as well as the reaction kinetics. Regeneration of spent periodate solutions by ozone was successfully performed in alkaline medium, which favors the formation of free (.) OH radicals, as supported by the addition of radical scavengers and quantum mechanical calculations. At pH 13 and an ozone concentration of approximately 150 mg L(-1) , periodate was completely regenerated from a 100 mm solution of iodate within 1 h at room temperature. A cyclic process of cellulose oxidation and subsequent regeneration of spent periodate with 90 % efficiency has been developed. So far, commercial applications of DAC have been hampered by difficulties in reusing the costly periodate. This work overcomes this hurdle and presents a highly efficient, clean, and low-cost protocol for the preparation of DAC with integrated periodate recycling, with the possibility of scaling the process up.

  9. Is psychotherapy mandatory during the acute refeeding period in the treatment of anorexia nervosa?

    PubMed

    Danziger, Y; Carel, C A; Tyano, S; Mimouni, M

    1989-07-01

    Forty-five adolescent and preadolescent patients (42 females, three males) with anorexia nervosa (AN) were treated in a pediatric day care unit of a large urban hospital by a multidisciplinary team. In our treatment model, the pediatrician has the responsibility for the initial evaluation and physical rehabilitation while the pediatric psychiatrist does the initial evaluation of the patient and family and is available for intervention in an emergency. Parents are actively involved in the treatment program. Family psychotherapy is recommended for each patient and his or her family. Among 45 patients, 24 did not enter psychotherapy during the first 2 months of the refeeding period, while the remaining 21 patients started psychotherapy (family and/or individual) during this period. Weight gain was higher in the group without formal psychotherapy during the initial period of refeeding (7.3 +/- 3.1 kg versus 5 +/- 2.5 kg; p less than 0.01). It is suggested that the initiation of structured psychotherapy is not mandatory and does not contribute to treatment effectiveness in the acute phase when emaciation and negativism may hinder the psychotherapeutic process. We believe a multidisciplinary team, together with the parents, is the treatment of choice during the acute phase of AN.

  10. [The treatment of bipolar disorder during pregnancy and the postpartum period].

    PubMed

    Gülöksüz, Sinan; Akdeniz, Fisun; Ince, Bahri; Oral, Esat Timuçin

    2010-01-01

    The prevalence of bipolar disorder (BD) in males and females is almost equal. The onset of BD in females typically occurs during the reproductive years, complicating its treatment. Although it was once believed that pregnancy prevents recurrence, studies have shown that recurrence is common and severe during pregnancy. On the other hand, the effects of pharmacological treatment on obstetrical outcome are not well known and some of these agents are considered teratogenic. Thus, the decision to treat pregnant patients with psychotropic agents requires solving an ethical dilemma. Risk-benefit decisions should be made while considering both the risk of relapse of BD and its morbidity, and the risk of fetal exposure to psychotropic medications. Moreover, the risk of recurrence increases dramatically in the postpartum period. It is well known that all of the psychotropic medications studied enter the breast milk. Thus, their effects on infants should be considered while prescribing for a breastfeeding mother. The aim of this review was to discuss the safety profiles of the treatment options for pregnant and breastfeeding BD patients. Firstly, each medication's effects on organ dysgenesis, neonatal toxicity, and neurobehavioral development, and their associated adverse events during pregnancy and the postpartum period are discussed, with a focus on the emerging literature. Given this background, practical suggestions on tailoring treatment in BD patients, from preconception to breastfeeding are highlighted.

  11. Treatment of Class II, Division 2 in the late growth period.

    PubMed

    Eberhard, H; Hirschfelder, U

    1998-01-01

    The "Deckbiss" with skeletal Class II jaw relationship sometimes presents a considerable therapeutic problem, particularly in the late growth period (DP3U), as regards the coordination of dental and skeletal treatment objectives. An effective treatment approach was demonstrated: a modified Herbst appliance used simultaneously with fixed appliances in the maxilla. The sample comprised 12 male (14.0 +/- 0.9 years old) and 10 female (12.3 +/- 0.4 years old) patients. Correction of the distal occlusion was achieved in all patients by means of the Herbst appliance, which was removed after an average time period of 6.4 +/- 0.2 months. In the mandible the multibracket appliances were then immediately inserted, and Class II elastics were used for retention. Maximum anchorage was required in the maxilla as well as in the mandible. Complete diagnostic records were made at the beginning of the treatment as well as 6 and 12 months later, in order to document skeletal and dental changes. A dental and skeletal Class I relationship was achieved in all cases. A significant improvement was recorded in the vertical jaw base relationship; this was still stable after a period of 12 months. In the dental area in particular, a so-called high-pull headgear effect (intrusion and distalization 16, 26) and intrusion of teeth 34, 44 were registered. Only a minor protrusion of the mandibular incisors was observed. Reinforcement of the bands reduced the failure rate significantly. The Herbst appliance does not represent a standard treatment for Class II. Its indication range is limited.

  12. Formation of nanoporous structures in metallic materials by pulse-periodic laser treatment

    NASA Astrophysics Data System (ADS)

    Murzin, Serguei P.

    2015-09-01

    A method of the formation of nanoporous structures in metallic materials by pulse-periodic laser treatment was developed. In this study, the multicomponent aluminum-iron brass was considered and the nanoporous structure across the entire cross section of the material with a thickness of 50 μm was formed. The method was implemented using a CO2 laser processing unit. The pulse-periodic laser treatment of the Cu-Zn-Al-Fe alloy with pulse frequency of 5 Hz has led to the formation of nanosized cavities due to accumulation of internal stresses during cyclic heating and cooling at high speeds. It was determined that the pores of a channel type with average widths of 80-100 nm are formed in the central region of the heat-affected zone during laser action with thermocycling. When implementing the chosen conditions of the pulse-periodic laser processing, the localness in depth and area of the physical processes occurring in the heat-affected zone is ensured, while maintaining the original properties of the material and the absence of significant deformations in the rest of the volume. This patented process is perspective for the production not only catalysts for chemical reactions, but for ultrafiltration and microfiltration membranes as well.

  13. 16 Weeks of Training with the International Space Station Advanced Resistive Exercise Device (aRED) Is not Different than Training with Free Weights

    NASA Technical Reports Server (NTRS)

    Loehr, J. A.; Lee, S. M. C.; English, K. E.; Leach, M.; Bentley, J.; Nash, R.; Hagan, R. D.

    2008-01-01

    The advanced Resistive Exercise Device (aRED) is a resistive exercise system designed to maintain muscle mass and strength in microgravity by simulating free weight (FW) exercise. aRED utilizes vacuum cylinders and inertial flywheels to replicate the constant mass and inertial components, respectively, of FW exercise in normal gravity. PURPOSE: To compare the effectiveness of aRED and FW resistive exercise training in ambulatory subjects. METHODS: Untrained subjects were assigned to two groups, FW (6 males, 3 females) and aRED (8 males, 3 females), and performed squat (SQ), heel raise (HR), and deadlift (DL) exercises 3 d wk-1 for 16 wks. SQ, HR and DL strength (1RM) were measured using FW hardware pre-, mid- and post-training. Subjects participated in a periodized training protocol with the exercise prescription based on a percentage of 1RM. Thigh and lower leg muscle volume were assessed using Magnetic Resonance Imaging (MRI), and leg (LLM) and total body lean mass (BLM) were measured using Dual Energy X-ray Absorptiometry (DXA) pre- and post-training. RESULTS: SQ 1RM increased in both FW (48.9+/-6.1%) and aRED (31.2+/-3.8%) groups, and there was a greater training response in FW compared with aRED (p=0.01). HR and DL 1RM increased in FW (HR: 12.3+/-2.4%, DL: 23.3+/-4.4%) and aRED (HR: 18.0+/-1.6%, DL: 23.2+'-2.8%), but there were no differences between groups. Thigh muscle volume was greater following training in both groups (FW: 9.8+/-0.9%, aRED: 7.1+/-1.2%) but lower leg muscle volume increased only in the FW group (3.0+/-1.1%). Lean tissue mass increased in both FW (LLM: 3.9+/-1.1%, BLM: 2.5+/-0.7%) and aRED (LLM: 4.8+/-0.7%, BLM: 2.6 0.7%). There were no between group differences in muscle volume or lean mass in response to training. CONCLUSIONS: In general, the increase in muscle strength, muscle volume, and lean tissue mass when training with aRED was not different than when using the same training protocol with FW. The smaller increase in SQ 1RM in the a

  14. Periodic mass treatment with diethylcarbamazine for the control of filariasis in American Samoa

    PubMed Central

    Kessel, John F.; Siliga, Nofo; Tompkins, Harry; Jones, Kenneth

    1970-01-01

    Filariasis surveys made during 1962-63 in 5 villages in American Samoa among persons over 5 years of age gave an elephantiasis rate of 3.4%, a microfilarial rate of 26% and a median microfilarial rate (MfD50) of 29. These rates were somewhat higher than those found in surveys made in the same villages among villagers of the same ages some 20 years previously. A mass treatment programme with diethylcarbamazine was then decided on. Preliminary treatment with a single total regimen of 72 mg of the drug per kg of body weight, given in 12 doses of 6 mg/kg, was administered in several villages over a period of 6 months. Among villagers of all ages at the end of 3 years, the microfilarial rate was 7.3% and the MfD50 value was 2. These results appeared to be inadequate for a successful control programme and a periodic mass treatment project of 2 or more regimens of 72 mg/kg to be administered every 2 years was instituted on the Island of Tutuila, to be continued until considered no longer necessary. Surveys made 2 years after the second mass treatment in the villages of Amouli, Amanave, Onenoa, Tula, Alao, Utumea and Alofau, in which 1407 persons were examined, showed that 3 villages were negative for microfilariae, that the average microfilarial rate in all 7 villages was 0.4% and that the MfD50 was 1. These villages were also negative in intensive mosquito surveys for infective-stage larvae of Wuchereria bancrofti. It is suggested that interruption of transmission has been observed in the 3 villages negative for both microfilariae and infective-stage larvae and that, if favourable surveys continue, eradication programmes should be established. PMID:4396819

  15. Treatment of bronchial asthma with low-level laser in attack-free period at children

    NASA Astrophysics Data System (ADS)

    Ailioaie, C.; Ailioaie, Laura

    2000-06-01

    Bronchial asthma is a common disease in both the pediatric and adult populations, characterized by wide variations over short periods of time in resistance to airflow in intrapulmonary airways. A primary goal in the use of low- level laser therapy (LLLT) was the safe, effective and rapid palliation of symptoms owing to tracheal or bronchial obstruction. We have investigated the effects of LLLT comparatively with other modality trials in children's asthma. In the study were included 98 patients aged 10-18 years diagnosed with moderate or severe asthma, in attack- free period. The patients were divided into 3 groups. Group 1 received only laser therapy using extra meridian acupuncture points and scanning technique. Group 2 was treated only with inhaled Serevent 2 X 25 micrometers , two times daily, 3 months. Group 3 was tread with Theophylline retard in dosage of 15-mg/kg/12 h, 3 months. At the end of treatment we remarked a noticeable improvement of the clinical, functional and immunological characteristics at 83 percent of patients in group 1, comparatively with only 70 percent (group 2) and 53 percent (group 3). The LLLT had a very good action on bronchial patency , displayed an immunocorrecting action and is recommended in attack-free periods at children.

  16. Comparing different treatment modalities for partial nephrectomies without ischemic period: laser, Hydro-Jet and RF

    NASA Astrophysics Data System (ADS)

    de Boorder, Tjeerd; Boeken Kruger, Arto; Klaessens, John; Grimbergen, Matthijs; Verdaasdonk, Rudolf

    2008-02-01

    The treatment of partial nefrectomies is usually performed under a warm ischemic period. Recently, various treatment modalities have become available to perform a partial nefrectomy without clamping off the blood circulation. We have studied three devices in laboratory setting, investigating the thermal and high speed imaging techniques in tissue models and consequently, applying the instruments in the clinic during open procedures especially looking at efficacy and blood loss. The continuous wave 2.0 micron laser of 70 W (Revolix, LISA laser) is used as a fiber delivered knife cutting through circulated tissue with controlled hemostasis for vessels up to 3 mm diameter. The 2 μm wavelength effectively vaporizes tissue water and coagulates the smaller vessels. The Hydro-Jet (ERBE, Germany) uses high pressure (20-80 bar) to ejects a water jet of 40 um diameter at high velocity (10-30 m/s). The parenchyma is resected while vessels are preserved. Consequently, the exposed vessels can be coagulated in a controlled way with minimal blood loss. The water jet showed to induce cavitation bubbles that resect the soft tissue from the matrix leaving the elastic microvessels intact. Various systems are based on bipolar RF technology. We are using the Habib device (Rita 1500X RF generator) to create a coagulation zone around the tumor. Subsequently, the tumor can be resected along the coagulation zone with minimal bleeding. The treatment modalities investigated, have their own advantages and, stand-alone or in combination, can facilitate laparoscopic partial nephrectomies without an ischemic period.

  17. Linear-scaling explicitly correlated treatment of solids: Periodic local MP2-F12 method

    SciTech Connect

    Usvyat, Denis

    2013-11-21

    Theory and implementation of the periodic local MP2-F12 method in the 3*A fixed-amplitude ansatz is presented. The method is formulated in the direct space, employing local representation for the occupied, virtual, and auxiliary orbitals in the form of Wannier functions (WFs), projected atomic orbitals (PAOs), and atom-centered Gaussian-type orbitals, respectively. Local approximations are introduced, restricting the list of the explicitly correlated pairs, as well as occupied, virtual, and auxiliary spaces in the strong orthogonality projector to the pair-specific domains on the basis of spatial proximity of respective orbitals. The 4-index two-electron integrals appearing in the formalism are approximated via the direct-space density fitting technique. In this procedure, the fitting orbital spaces are also restricted to local fit-domains surrounding the fitted densities. The formulation of the method and its implementation exploits the translational symmetry and the site-group symmetries of the WFs. Test calculations are performed on LiH crystal. The results show that the periodic LMP2-F12 method substantially accelerates basis set convergence of the total correlation energy, and even more so the correlation energy differences. The resulting energies are quite insensitive to the resolution-of-the-identity domain sizes and the quality of the auxiliary basis sets. The convergence with the orbital domain size is somewhat slower, but still acceptable. Moreover, inclusion of slightly more diffuse functions, than those usually used in the periodic calculations, improves the convergence of the LMP2-F12 correlation energy with respect to both the size of the PAO-domains and the quality of the orbital basis set. At the same time, the essentially diffuse atomic orbitals from standard molecular basis sets, commonly utilized in molecular MP2-F12 calculations, but problematic in the periodic context, are not necessary for LMP2-F12 treatment of crystals.

  18. Activated sludge wastewater treatment plants optimisation to face pollution overloads during grape harvest periods.

    PubMed

    Beck, C; Prades, G; Sadowski, A G

    2005-01-01

    The principal objective of our study was to optimise a municipal activated sludge wastewater treatment plant (WWTP) to face high organic flows due to viticulture effluents inputs. Treatment file optimization consisted in testing different treatment lines, changing the number and volume of biological basins and clarifiers, with or without a buffer basin upstream, with a view to achieving a better reduction of COD. The actual WWTP biological stage is composed of two aerated basins whose total volume is 1365 m3. The studied cases are successively, the installation of a single basin of 1365 m3, then of several basins whose total volume remains constant and equal to 1365 m3. Another case was also considered, that of an aerated basin followed by a first clarifier and then, by another aerated basin and a second clarifier. All scenarios presented below were evaluated, for standard dry weather conditions and for high organic load conditions, as encountered during the grape harvest period. The method used was to carry out various simulations, using numerical modelling, and to compare the impact of different process line scenarios and management strategies on the activated sludge WWTP efficiencies.

  19. Unified Protocol for Transdiagnostic Treatment of Emotional Disorders: A Randomized Controlled Trial

    PubMed Central

    Farchione, Todd J.; Fairholme, Christopher P.; Ellard, Kristen K.; Boisseau, Christina L.; Thompson-Hollands, Johanna; Carl, Jenna R.; Gallagher, Matthew W.; Barlow, David H.

    2012-01-01

    This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n= 11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders. PMID:22697453

  20. Unified protocol for transdiagnostic treatment of emotional disorders: a randomized controlled trial.

    PubMed

    Farchione, Todd J; Fairholme, Christopher P; Ellard, Kristen K; Boisseau, Christina L; Thompson-Hollands, Johanna; Carl, Jenna R; Gallagher, Matthew W; Barlow, David H

    2012-09-01

    This study further evaluates the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). A diagnostically heterogeneous clinical sample of 37 patients with a principal anxiety disorder diagnosis was enrolled in a randomized controlled trial (RCT) involving up to 18 sessions of treatment and a 6-month follow-up period. Patients were randomly assigned to receive either immediate treatment with the UP (n=26) or delayed treatment, following a 16-week wait-list control period (WLC; n=11). The UP resulted in significant improvement on measures of clinical severity, general symptoms of depression and anxiety, levels of negative and positive affect, and a measure of symptom interference in daily functioning across diagnoses. In comparison, participants in the WLC condition exhibited little to no change following the 16-week wait-list period. The effects of UP treatment were maintained over the 6-month follow-up period. Results from this RCT provide additional evidence for the efficacy of the UP in the treatment of anxiety and comorbid depressive disorders, and provide additional support for a transdiagnostic approach to the treatment of emotional disorders.

  1. Reference datasets for 2-treatment, 2-sequence, 2-period bioequivalence studies.

    PubMed

    Schütz, Helmut; Labes, Detlew; Fuglsang, Anders

    2014-11-01

    It is difficult to validate statistical software used to assess bioequivalence since very few datasets with known results are in the public domain, and the few that are published are of moderate size and balanced. The purpose of this paper is therefore to introduce reference datasets of varying complexity in terms of dataset size and characteristics (balance, range, outlier presence, residual error distribution) for 2-treatment, 2-period, 2-sequence bioequivalence studies and to report their point estimates and 90% confidence intervals which companies can use to validate their installations. The results for these datasets were calculated using the commercial packages EquivTest, Kinetica, SAS and WinNonlin, and the non-commercial package R. The results of three of these packages mostly agree, but imbalance between sequences seems to provoke questionable results with one package, which illustrates well the need for proper software validation.

  2. Interleukin-1 antagonists in the treatment of autoinflammatory syndromes, including cryopyrin-associated periodic syndrome

    PubMed Central

    Quartier, Pierre

    2011-01-01

    Cryopyrin-associated periodic syndrome (CAPS) include a group of rare autoinflammatory disorders, the spectrum of which ranges from the mildest form, ie, familial cold autoinflammatory syndrome to more severe phenotypes, ie, Muckle-Wells syndrome, and chronic infantile neurological cutaneous and articular syndrome, also known as neonatal-onset multisystem inflammatory disease. Three interleukin (IL)-1 antagonists have been tested in adults and children with CAPS, ie, anakinra, a recombinant homolog of the human IL-1 receptor antagonist; rilonacept, a fusion protein comprising the extracellular domains of IL-1 receptor I and the IL-1 adaptor protein, IL-1RAcP, attached to a human immunoglobulin G molecule; and canakinumab, the anti-IL-1β monoclonal antibody. Following rapid clinical development, rilonacept and canakinumab were approved by both the US Food and Drug Administration and the European Medicines Agency for use in adults and children. This review describes how the study of CAPS has helped us to understand better the way the innate immune system works, the pathogenesis of autoinflammatory syndromes, and the key role of IL-1. It also reviews the effects of IL-1 blockade in CAPS and other disorders, in particular systemic juvenile idiopathic arthritis, adult-onset Still’s disease, and gout. Finally, this review covers some issues addressed by very recent and ongoing work regarding treatment indications, from orphan diseases to common disorders, continuous versus intermittent treatment, the pharmacokinetics, pharmacodynamics, and optimal dosages of the different drugs, as well as the need for Phase IV trials, exhaustive registries, and long-term follow-up of several patient cohorts.

  3. Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin-associated periodic syndromes

    PubMed Central

    Bachove, Inessa; Chang, Christopher

    2014-01-01

    Anakinra is an interleukin (IL) receptor antagonist that works by blocking the biological activity of IL-1 by competitively inhibiting binding of IL-1 to the type 1 interleukin receptor. IL-1 production is induced in response to inflammatory stimuli and mediates various physiological mechanisms, including inflammation and immunological reactions. Patients with neonatal onset multisystem inflammatory disease (NOMID) produce excess IL-1β, a major proinflammatory cytokine that regulates innate immune responses. Anakinra binds competitively and this results in a rapid reduction in disease severity. NOMID, also known as chronic infantile neurologic, cutaneous, articular syndrome, is the most severe clinical phenotype in the spectrum of cryopyrin-associated periodic syndromes. It is characterized by cutaneous symptoms, arthropathy, and central nervous system involvement. Extensive studies in patients with NOMID have led to advances in characterizing the extent of organ-specific involvement and damage that occurs with chronic overproduction of IL-1β. NOMID is caused predominantly by mutations in the NLRP3/CIAS1 gene that encodes for the protein cryopyrin, leading to activation of the “NLRP3 inflammasome complex”. This in turn regulates the maturation and secretion of the inflammatory cytokine, IL-1β. The clinical value of IL-1β has been demonstrated by the positive response of patients after treatment with anakinra, with rapid improvement in clinical symptoms, markers of inflammation, and a significant decrease in major organ manifestations.

  4. [The prevalence, prevention and treatment of cattle epidemic during the Han-Tang Period].

    PubMed

    Han, Yi

    2013-03-01

    About 21 times of cattle epidemic with rather strong infectivity happened during the Han-Tang Period, including 6 in the Eastern Han Dynasty, 2 in the Jin Dynasty, 4 in the Southern and Northern Dynasties, 8 in the Tang Dynasty and 1in the Five Dynasty. Most of them were spread along the Yellow River and the northern region of the Huai River. The type of cattle epidemic included the acute cattle plague, cattle bovine mange, cattle yellow fever and cattle rotten hoof disease, etc. Its occurrence and prevalence brought a serious influentce on the society of the Han and Tang Dynasties, causing massive mortality of farm cattle, and then the shortage of animal power, and threatening the agriculture, which drew the attention of the governments, physicians, agriculturists, astrologists and Taoists. The medical measures and economic measures were adopted for the prevention and treatment of cattle epidemic. Especially, prescriptions in the books of medicine and agriculture exerted positive effects on the containment of cattle epidemic. On the other hand, its prevalence and the mass mortality of farm cattle, in a way, promoted, to certain extent, the improvement of the government's function of relief, the updating of the methods of agriculture and the creation of new farm tools, and being regarded as a main cause for the technological innovation of agriculture.

  5. Determination of rifaximin treatment period according to lactulose breath test values in nonconstipated irritable bowel syndrome subjects.

    PubMed

    Bae, Suhyun; Lee, Kwang Jae; Kim, Young-Sang; Kim, Kyu-Nam

    2015-06-01

    Small intestinal bacterial overgrowth (SIBO) can partly explain irritable bowel syndrome (IBS), and rifaximin has been observed to improve abdominal symptoms in nonconstipated IBS patients. However, there are few reports on the association of the rifaximin treatment periods with the results of a lactulose breath test (LBT). Therefore, we performed a retrospective review of patient charts to investigate the relation between the rifaximin treatment periods with LBT results in nonconstipated IBS patients. We also evaluated the time to achieve a symptomatic improvement in the IBS patients as compared to the changes in the LBT. We reviewed the charts for patients who showed IBS symptoms with documented positive results for LBT during their initial visit and who had a follow-up LBT after treatment with rifaximin. The LBT values were compared to the subjects' symptom scores. A total of 102 subjects had a follow-up LBT to assess LBT normalization. The subjects were divided into groups according to treatment periods of 4 weeks (n = 36), 8 weeks (n = 43), and 12 weeks (n = 23). The groups with a longer treatment exhibited an increase in the hydrogen gas value at 90 min and its sum during 90 min at the initial LBT. There were significant differences in hydrogen gas value at 90 min and in its sum during 90 min at the initial LBT between the groups treated for 4 and 12 weeks. The most significant treatment response was observed during the first 4 weeks for all treatment groups. Symptomatic improvement occurred earlier than LBT normalization in the treatment period over 4 weeks. The results indicate that different rifaximin treatment periods are needed in accordance with LBT levels to effectively eradicate SIBO. PMID:26028929

  6. Effects on outpatient and emergency mental health care of strict Medicaid early periodic screening, diagnosis, and treatment enforcement.

    PubMed

    Snowden, Lonnie R; Masland, Mary C; Wallace, Neal T; Evans-Cuellar, Allison

    2007-11-01

    We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed-effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (out-patient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims.

  7. Contingency Management for Attendance to Group Substance Abuse Treatment Administered by Clinicians in Community Clinics

    ERIC Educational Resources Information Center

    Ledgerwood, David M.; Alessi, Sheila M.; Hanson, Tressa; Godley, Mark D.; Petry, Nancy M.

    2008-01-01

    Contingency management (CM) is effective in enhancing retention in therapy. After an 8-week baseline, four community-based substance abuse treatment clinics were exposed in random order to 16 weeks of standard care with CM followed by 16 weeks of standard care without CM or vice versa. In total, 75 outpatients participated. Patients who were…

  8. Theoretical treatment of the interaction between two-level atoms and periodic waveguides.

    PubMed

    Zang, Xiaorun; Lalanne, Philippe

    2015-08-15

    Light transport in periodic waveguides coupled to two-level atoms is investigated theoretically. By using optical Bloch equations and a photonic modal formalism, we derive a convenient semi-analytical expression for calculating the scattering matrix of single atoms trapped in periodic waveguides. The expression that holds for both photonic and plasmonic waveguides represents a basic building block toward the study of collective effects arising from photon-mediated multi-atom interactions in periodic waveguides. PMID:26274681

  9. From methadone to buprenorphine: changes during a 10 year period within a national opioid maintenance treatment programme.

    PubMed

    Riksheim, Marianne; Gossop, Michael; Clausen, Thomas

    2014-03-01

    Opioid maintenance treatment (OMT) is the most widely used treatment for opioid dependence. Maintenance programmes differ in various aspects and may also change over time. This paper investigates the changes in treatment practices within a national OMT programme during a 10 year period (2002-2011), especially with regard to the prescribing of methadone and buprenorphine. Data (n=34,001) were collected by annual assessments questionnaires. In 2002, only 16% of the OMT patients received buprenorphine as their maintenance medication. By 2011 this percentage had increased significantly (p<.001) to 50.3%. In the same period the number of patients more than tripled (from 1,984 to 6,640, p<.001), and programme attrition rates decreased (p=.020). This relatively rapid shift is a part of the increasing reliance of addiction medicine upon a range of medications administered by different routes which has not been previously charted within a national treatment programme.

  10. Use of antidepressants in the treatment of major depressive disorder in primary care during a period of economic crisis

    PubMed Central

    Sicras-Mainar, Antoni; Navarro-Artieda, Ruth

    2016-01-01

    Objective To describe antidepressant (AD) use in the treatment of major depressive disorder during a period of economic crisis. Patients and methods This was a retrospective, observational study using population-based databases. Two periods were considered: 1) 2008–2009, precrisis, and 2) 2012–2013, economic crisis. Certain inclusion/exclusion criteria were taken into account for the study (initiation of AD treatment). Patients were followed up for 12 months. The main measures were use (defined daily doses), epidemiologic measures, strategies used and treatment persistence, referrals, and use of resources. Statistical significance was set at P<0.05. Results In the precrisis period, 3,662 patients were enrolled, and 5,722 were enrolled in the period of economic crisis. Average age was 58.8 years and 65.4% were women. Comparing the two periods, major depressive disorder prevalence was 5.4% vs 8.1%, P<0.001. During the period of economic crisis, AD use rose by 35.2% and drug expenditures decreased by 38.7%. Defined daily dose per patient per day was 10.0 mg vs 13.5 mg, respectively, P<0.001. At 12-month follow-up, the majority of patients (60.8%) discontinued the treatment or continued on the same medication as before, and in 23.3% a change of AD was made. Conclusion Primary health care professionals are highly involved in the management of the illness; in addition, during the period of economic crisis, patients with major depressive disorder showed higher rates of prevalence of the illness, with increased use of AD drugs. PMID:26766910

  11. A Guide to Dental Care for the Early and Periodic Screening, Diagnosis, and Treatment Program (EPSDT) Under Medicaid.

    ERIC Educational Resources Information Center

    Lindahl, Roy L.; Young, Wesley O.

    This guide has been developed to assist administrators, providers of dental care, and others involved in carrying out the dental care provisions of the EPSDT program (Early and Periodic Screening, Diagnosis, and Treatment Program). It is intended to assist in the development of programs concerned with the unique characteristics of dental diseases…

  12. EPSDT: Child Health. Child Health Information for Workers in the Medicaid Early and Periodic Screening Diagnosis and Treatment Program.

    ERIC Educational Resources Information Center

    Manela, Roger; And Others

    One of six information booklets with accompanying training materials for the Medicaid Early and Periodic Screening Diagnosis and Treatment (EPSDT) program, this booklet describes the stages of child growth and development and some of the health problems which EPSDT clients might have. Section I describes tests commonly included in an EPSDT…

  13. Improvements Needed to Speed Implementation of Medicaid's Early and Periodic Screening, Diagnosis, and Treatment Program...Report to the Congress.

    ERIC Educational Resources Information Center

    Comptroller General of the U.S., Washington, DC.

    Congressman Ralph H. Metcalfe asked the General Accounting Office (GAO) to review implementation of the Medicaid Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) program administered by the Department of Health, Education, and Welfare's (HEW's) Social and Rehabilitation Service (SRS). An estimated 10 million children under age 21 are…

  14. A Guide to Screening for the Early and Periodic Screening, Diagnosis and Treatment Program (EPSDT) Under Medicaid.

    ERIC Educational Resources Information Center

    Frankenburg, William K.; North, A. Frederick, Jr.

    The manual was designed to help public officials, physicians, nurses, and others to plan and implement an Early and Periodic Screening, Diagnosis and Treatment (EPSDT) program under Medicaid. Procedures for carrying out components of an EPSDT program are recommended. Part 1 discusses organization and administration of screening, diagnosis, and…

  15. Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression.

    PubMed

    Vaidya, Bipin; Cho, Se-Young; Oh, Kyung-Seo; Kim, Song Hak; Kim, Yeong O; Jeong, Eun-Hye; Nguyen, Thoa Thi; Kim, Sung Hyun; Kim, In Seon; Kwon, Joseph; Kim, Duwoon

    2016-06-01

    Kimchi, a traditional fermented food regularly consumed in Korea, contains various types of antimicrobial compounds. Among the tested compounds present in common spices used in Kimchi, quercetin showed the highest selectivity index against influenza A virus (IAV) H1N1. In this study, the effect of pretreatment and periodic treatment with quercetin against IAV in Madin-Darby canine kidney cells was observed. Compared to pretreatment, periodic treatment resulted in significantly higher cell viability but lower relative expression of the IAV PA gene and total apoptosis and cell death. To explain the mechanisms underlying the antiviral effects of quercetin treatment, a comparative proteomic analysis was performed in four samples (mock, quercetin-treated, IAV-infected, and quercetin-treated IAV-infected). Among the 220 proteins, 56 proteins were classified nonhierarchically into three clusters and were differentially modulated by quercetin treatment in IAV-infected cells. Post-translational modifications were identified in 68 proteins. In conclusion, periodic treatment with quercetin is effective in reducing IAV infection, and differentially regulates the expression of key proteins, including heat shock proteins, fibronectin 1, and prohibitin to reduce IAV replication.

  16. Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression.

    PubMed

    Vaidya, Bipin; Cho, Se-Young; Oh, Kyung-Seo; Kim, Song Hak; Kim, Yeong O; Jeong, Eun-Hye; Nguyen, Thoa Thi; Kim, Sung Hyun; Kim, In Seon; Kwon, Joseph; Kim, Duwoon

    2016-06-01

    Kimchi, a traditional fermented food regularly consumed in Korea, contains various types of antimicrobial compounds. Among the tested compounds present in common spices used in Kimchi, quercetin showed the highest selectivity index against influenza A virus (IAV) H1N1. In this study, the effect of pretreatment and periodic treatment with quercetin against IAV in Madin-Darby canine kidney cells was observed. Compared to pretreatment, periodic treatment resulted in significantly higher cell viability but lower relative expression of the IAV PA gene and total apoptosis and cell death. To explain the mechanisms underlying the antiviral effects of quercetin treatment, a comparative proteomic analysis was performed in four samples (mock, quercetin-treated, IAV-infected, and quercetin-treated IAV-infected). Among the 220 proteins, 56 proteins were classified nonhierarchically into three clusters and were differentially modulated by quercetin treatment in IAV-infected cells. Post-translational modifications were identified in 68 proteins. In conclusion, periodic treatment with quercetin is effective in reducing IAV infection, and differentially regulates the expression of key proteins, including heat shock proteins, fibronectin 1, and prohibitin to reduce IAV replication. PMID:27157719

  17. Defaulting from tuberculosis treatment in The Netherlands: rates, risk factors and trend in the period 1993-1997.

    PubMed

    Borgdorff, M W; Veen, J; Kalisvaart, N A; Broekmans, J F; Nagelkerke, N J

    2000-08-01

    The aim of this study was to assess the rate of defaulting from treatment among tuberculosis patients diagnosed in the Netherlands in the period 1993-1997, whether risk groups for defaulting can be identified at the start of treatment and the trend of defaulting over time. The Netherlands Tuberculosis Register provided data on all patients diagnosed in the Netherlands during the period 1993-1997. Defaulting probabilities were determined using Kaplan-Meier survival analysis and risk factors were identified with Cox's proportional hazard analysis. Of 7,529 patients with reported treatment outcome, 718 (10%) defaulted or left the country within 1 yr after starting treatment. Defaulting probabilities were 9% (95% confidence interval (CI) 8-10%) among 5,256 patients in low-risk groups, 17% (95% CI 14-19%) among 1,437 asylum seekers and 29% (95% CI 24-34%) among 836 patients in other high-risk groups (other recent immigrants, illegal immigrants, the homeless, prisoners and nationals from Eastern Europe). Defaulting probabilities decreased over time from 12% in 1993 to 7% in 1997. Risk groups for defaulting can be recognized at the start of treatment. The decreasing defaulting probabilities were probably due in part to shortening treatment from 9 to 6 months and improved follow-up of asylum seekers. However, additional measures are needed to reduce defaulting among the homeless, recent immigrants, illegal immigrants and prisoners.

  18. Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods.

    PubMed

    Simão, Vinícius Augusto; Berloffa Belardin, Larissa; Araújo Leite, Gabriel Adan; de Almeida Chuffa, Luiz Gustavo; Camargo, Isabel Cristina Cherici

    2015-10-01

    This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treated with ND at doses of 1.87, 3.75, 7.5 and 15 mg/kg body weight, or received mineral oil (control group) for 15 days, subcutaneously. All animals were divided into three groups according to the treatment periods: (i) ND treatment for 15 days; (ii) ND treatment followed by a 30-day recovery; and (iii) ND treatment followed by a 60-day recovery. Estrous cycle was monitored daily, and at the end of each period, the animals were euthanized for histopathological analysis. During ND treatment and after 30-day recovery, all animals exhibited persistent diestrus. After a 60-day recovery, persistent diestrus was only maintained in the group that had received the highest dose. Ovarian weight was decreased significantly after the 30-day recovery, regardless of ND doses, compared with the control group. There was a reduction (P < 0.05) in the number of corpora lutea and antral and growing follicles, in contrast to an increase (P < 0.05) in atretic follicles in a dose- and time-dependent manner. Remarkable histopathological changes occurred in the ovaries of all ND-treated groups. In conclusion, the different doses of ND caused changes in the estrous cycle and ovarian tissue of rats, and recovery periods (30 and 60 days) were insufficient to completely restore the damage in the animals treated with the highest dose. PMID:26575430

  19. Successful treatment of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) with tocilizumab: A case report

    PubMed Central

    Akasbi, Nessrine; Soyfoo, Muhammad S.

    2015-01-01

    Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory disease linked to chromosome 12p13 and, more specifically, with mutations within the tumor necrosis factor receptor superfamily, member 1A gene (TNFRSF1A gene). It is characterized by the presence of fever, abdominal pain, myalgia, arthralgia or arthritis, and skin rash. In this report, we describe the case of a patient with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) treated successfully with the anti-interleukin-6 (anti-IL-6) receptor monoclonal antibody tocilizumab, while treatment with anti-TNF α etanercept and infliximab had both failed.

  20. Spectroscopic characterization of bone tissue of experimental animals after glucocorticoid treatment and recovery period

    NASA Astrophysics Data System (ADS)

    Mitić, Žarko J.; Najman, Stevo J.; Cakić, Milorad D.; Ajduković, Zorica R.; Ignjatović, Nenad L.; Nikolić, Ružica S.; Nikolić, Goran M.; Stojanović, Sanja T.; Vukelić, Marija Đ.; Trajanović, Miroslav D.

    2014-09-01

    The influence of glucocorticoids on the composition and mineral/organic content of the mandible in tested animals after recovery and healing phase was investigated in this work. The results of FTIR analysis demonstrated that bone tissue composition was changed after glucocorticoid treatment. The increase of calcium, magnesium, phosphorus content and mineral part of bones was statistically significant in recovery phase and in treatment phase that included calcitonin and thymus extract. Some changes also happened in the organic part of the matrix, as indicated by intensity changes for already present IR bands and the appearance of new IR bands in the region 3500-1300 cm-1.

  1. CRYSCOR: a program for the post-Hartree-Fock treatment of periodic systems.

    PubMed

    Pisani, Cesare; Schütz, Martin; Casassa, Silvia; Usvyat, Denis; Maschio, Lorenzo; Lorenz, Marco; Erba, Alessandro

    2012-06-01

    Cryscor is a periodic post-Hartree-Fock program based on local functions in direct space, i.e., Wannier functions and projected atomic orbitals. It uses atom centered Gaussians as basis functions. The Hartree-Fock reference, as well as symmetry information, is provided by the Crystal program. Cryscor presently features an efficient and parallel implementation of periodic local second order Møller-Plesset perturbation theory (MP2), which allows us to study 1D-, 2D- and 3D-periodic systems beyond 1000 basis functions per unit cell. Apart from the correlation energy also the MP2 density matrix, and from that the Compton profile, are available. Very recently, a new module for calculating excitonic band gaps at the uncorrelated Configuration-Interaction-Singles (CIS) level has been added. Other advancements include new extrapolation techniques for calculating surface adsorption on semi-infinite solids. In this paper the diverse features and recent advances of the present Cryscor version are illustrated by exemplary applications to various systems: the adsorption of an argon monolayer on the MgO (100) surface, the rolling energy of a boron nitride nanoscroll, the relative stability of different aluminosilicates, the inclusion energy of methane in methane-ice-clathrates, and the effect of electron correlation on charge and momentum density of α-quartz. Furthermore, we present some first tentative CIS results for excitonic band gaps of simple 3D-crystals, and their dependence on the diffuseness of the basis set. PMID:22334044

  2. Recidivism among Juvenile Offenders over Periods Ranging from One to Twenty Years following Residential Treatment

    ERIC Educational Resources Information Center

    McMackin, Robert A.; Tansi, Robert; Lafratta, Joseph

    2004-01-01

    This paper examines the recidivism data for juvenile offenders discharged from a Massachusetts residential treatment center between 1976 and 1995. The criminal histories, juvenile and adult, of 162 delinquent youth referred through the Massachusetts Department of Youth Services who left the program were reviewed. Recidivism was defined as any…

  3. [Clinical and pharmacoeconomic peculiarities of the treatment with cerebrolysin in the period of rehabilitation of is ischemic stroke.].

    PubMed

    Gusev, E I; Gekht, A B; Belousov, Iu B; Pavlov, N A; Galanov, D V; Popov, G R; Mil'chakova, L E

    2007-01-01

    The results of the clinical and pharmacoeconomic study of cerebrolysin in the rehabilitative therapy of ischemic stroke presented in the paper revealed the statistically significant regress of neurological disturbances in patients receiving cerebrolysin in daily dosages of 10 and 20 ml as compared to the control group. The rehabilitation of motor functions was more rapid than sensitive ones in patients receiving cerebrolysin comparing to those switched to the basic antihypertensive and antiaggregate therapy. The positive dynamics of speech rehabilitation was observed, the regress of aphatic disturbances being more significant for daily dosage of 20 ml. Rehabilitation rate in the period of treatment with cerebrolysin was higher for daily dosage of 20 ml than that of 10 ml. A prolonged effect of the drug during the long period after its withdrawal was found that resulted in higher rates of rehabilitation to the 11th week in patients receiving cerebrolysin as compared to the control group. Average total cost of direct medical expenses per a patient estimated in the pharmacoeconomic analysis for the groups receiving cerebrolysin and the control group was higher in the former groups, in particular in that with 20 ml dosage of cerebrolysin. A cost-efficacy analysis revealed that the cost of cerebrolysin treatment per effective unit (a cost of one score on the Lindmark scale and the Barthel scale) was less or comparable in patients receiving cerebrolysin comparing to the control group. The study suggests clinical and pharmacoeconomic expediency of cerebrolysin treatment in rehabilitative period of ischemic stroke.

  4. Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats.

    PubMed

    Rai, K S; Murthy, K D; Karanth, K S; Rao, M S

    2001-07-01

    Neonatal rat pups (7 days old) were intubated with either 50 mg/kg body weight or 100 mg/kg body weight of aqueous root extract of Clitoria ternatea (CTR) for 30 days. These rats were then subjected to open field, two compartment passive avoidance and spatial learning (T-Maze) tests (i) immediately after the treatment and (ii) 30 days after the treatment, along with age matched normal and saline control rats. Results showed no change in open field behaviour, but showed improved retention and spatial learning performance at both time points of behavioural tests, indicating the memory enhancing property of CTR which implicates a permanent change in the brain of CTR treated rats. PMID:11881569

  5. A Case Report on Juvenile Neuromyelitis Optica: Early Onset, Long Remission Period, and Atypical Treatment Response.

    PubMed

    Elpers, Christiane; Gross, Catharina C; Fiedler, Barbara; Meuth, Sven G; Kurlemann, Gerhard

    2015-08-01

    Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system and preferentially targets the optic nerves and spinal cord. NMO is rare in children and clinical course of the disease is highly variable as described in studies. Here, we present a case report of a young girl presenting with a rare course of pediatric NMO with an early disease onset at the age of 12 years, a relapse free interval of 4 years, evidence of NMO immunoglobulin G (IgG) and an unusual response against immunosuppressive therapy. The aim of this report is to highlight the potentially long remission period between relapses complicating proper diagnosis despite well defined diagnostic criteria. In addition, we want to encourage the use of rituximab in pediatric NMO, although larger cohorts are warranted to establish B cell depleting therapies in juvenile NMO.

  6. Current treatment recommendations and considerations for cryopyrin-associated periodic syndrome.

    PubMed

    Koné-Paut, Isabelle; Galeotti, Caroline

    2015-01-01

    Cryopyrin-associated periodic syndrome (CAPS) encompasses a spectrum of three phenotypes of increasing severity. The syndrome is due to dominant mutations in NLRP3, which encodes a key component of the innate immunity that regulates the secretion of IL-1β. CAPS manifests as systemic inflammation, which compromises quality of life and leads to serious complications and handicap. Anti-IL-1 drugs have shown remarkable efficacy in treating CAPS symptoms and have significantly changed patients' lives. They have acceptable safety profiles but do have some differences. We review three drugs that are currently marketed for CAPS, give additional information for the practical use of these drugs, and provide some recommendations for management. PMID:26312542

  7. Dark Period Following UV-C Treatment Enhances Killing of Botrytis cinerea Conidia and Controls Gray Mold of Strawberries.

    PubMed

    Janisiewicz, Wojciech J; Takeda, Fumiomi; Glenn, D Michael; Camp, Mary J; Jurick, Wayne M

    2016-04-01

    Strawberries are available throughout the year either from production in the field or from high and low tunnel culture. Diversity of production conditions results in new challenges in controlling diseases before and after harvest. Fungicides have traditionally been used to control these diseases; however, their limitations necessitate a search for new approaches. We found that UV-C irradiation of Botrytis cinerea, a major pathogen of strawberry, can effectively kill this fungus if a dark period follows the treatment. The inclusion of a 4-h dark period resulted in almost complete kill of B. cinerea conidia on agar media at a dose of 12.36 J/m2. The UV-C dose did not cause a reduction in photosynthesis in strawberry leaves or discoloration of sepals, even after exposing plants repeatedly (twice a week) for 7 weeks. Although irradiation of dry conidia of B. cinerea with this dose resulted in some survival, the conidia were not infective and not able to cause decay even when inoculated onto a highly susceptible mature apple fruit. Irradiation of strawberry pollen at 12.36 J/m2 did not affect pollen germination, tube growth and length in vitro, or germination and tube growth in the style of hand-pollinated emasculated strawberry flowers. No negative effect of the UV-C treatment was observed on fruit yield and quality in high tunnel culture. In the fruit and flower petal inoculation tests, the UV-C treatment was highly effective in reducing fruit decay and petal infection. This UV-C treatment with an exposure time of 60 s may be useful in controlling gray mold in tunnel production of strawberries and may also have the potential for use in intensive field and indoor production of other fruits and vegetables providing that a 4-h dark period follows the irradiation.

  8. Dark Period Following UV-C Treatment Enhances Killing of Botrytis cinerea Conidia and Controls Gray Mold of Strawberries.

    PubMed

    Janisiewicz, Wojciech J; Takeda, Fumiomi; Glenn, D Michael; Camp, Mary J; Jurick, Wayne M

    2016-04-01

    Strawberries are available throughout the year either from production in the field or from high and low tunnel culture. Diversity of production conditions results in new challenges in controlling diseases before and after harvest. Fungicides have traditionally been used to control these diseases; however, their limitations necessitate a search for new approaches. We found that UV-C irradiation of Botrytis cinerea, a major pathogen of strawberry, can effectively kill this fungus if a dark period follows the treatment. The inclusion of a 4-h dark period resulted in almost complete kill of B. cinerea conidia on agar media at a dose of 12.36 J/m2. The UV-C dose did not cause a reduction in photosynthesis in strawberry leaves or discoloration of sepals, even after exposing plants repeatedly (twice a week) for 7 weeks. Although irradiation of dry conidia of B. cinerea with this dose resulted in some survival, the conidia were not infective and not able to cause decay even when inoculated onto a highly susceptible mature apple fruit. Irradiation of strawberry pollen at 12.36 J/m2 did not affect pollen germination, tube growth and length in vitro, or germination and tube growth in the style of hand-pollinated emasculated strawberry flowers. No negative effect of the UV-C treatment was observed on fruit yield and quality in high tunnel culture. In the fruit and flower petal inoculation tests, the UV-C treatment was highly effective in reducing fruit decay and petal infection. This UV-C treatment with an exposure time of 60 s may be useful in controlling gray mold in tunnel production of strawberries and may also have the potential for use in intensive field and indoor production of other fruits and vegetables providing that a 4-h dark period follows the irradiation. PMID:26714103

  9. [Asthenic syndrome in clinical course of acute period of brain concussion during complex treatment using nootropic agents].

    PubMed

    Tkachov, A V

    2008-01-01

    The comparative analysis of a complex examination of 108 persons aged from 16 till 60 years in acute period of closed craniocerebral injury (CCCT) has been done. Every participants have been divided into 2 groups depending on a nootrop medication they receive in a complex treatment. A control group consisted of 30 practically healthy people. Objective examination by means of tests was done on the 1-st, 10-th that 30-th day of treatment. Patients of 1-st (37 persons) group received piracetam in complex treatment and patients of the 2-nd group (71 persons) pramistar. Patients of the first group received a base treatment (analgetics, tranquilizers, vitamins of group B, magnesium sulfate, diuretic preparations) as well as piracetam at dosage 0.2, two tablets three times per day. The Patients of the 2-nd group received a base treatment as well as pramistar at dosage 0.6, one tablet 2 times per day. Specially developed multiaspects scales and questionnaires, MRT of the brain and EEG have been used for objectification of patient, complaints. During a complex clinico-neuropsychological examination it was found that all cases of concussion of the brain are accompanied by those or other asthenic disorders.

  10. Cutting-Balloon Angioplasty in Transplant Renal Artery Stenosis as First-Line Treatment in the Early Postoperative Period

    SciTech Connect

    Ucar, Adem; Yahyayev, Aghakishi; Bakkaloglu, Huseyin; Agayev, Ayaz; Aydin, Ali Emin; Rozanes, Izzet

    2011-02-15

    Percutaneous transluminal angioplasty has been successfully used for the treatment of transplant renal artery stenosis (RAS). Cutting-balloon angioplasty (CBA) is being used as a second option in pressure-resistant stenosis. It is thought that CBA is less traumatic and therefore restenosis occurs less frequently than in conventional angioplasty. This case report describes the unusual use of a cutting balloon in transplant RAS as a first option in the early postoperative period. Long-term follow-up data are also presented.

  11. [Complex pathogenetic treatment schemes of vascular dyscirculatory disorders in the remote period after exposure to low dose radiation].

    PubMed

    Holodova, N B; Zhavoronkova, L A; Ryzhov, B N

    2013-01-01

    Complex studies including modern methods of investigation of structures and functions of nervous system: electroencephalograsphy (EEG), coherent analysis, neuropsychological study and methods of neuroimaging were performed in 517 participants in liquidation of consequences of the accident (LCA) at the Chernobyl NPP in 1986-1987. Dyscirculatory metabolic encephalopathy was revealed to be the main pathology with the etiological mechanism based on dyscirculatorhypoxic and metabolic disorders. Complexity of the revealed symptoms testified to an early organism aging in remote periods after exposure to low dose radiation. Pathogenetic schemes were developed for treatment of dyscirculatory encephalopathy in liquidators, which include drugs improving blood supply, antiaggregants, antioxidants and metabolites of the brains in various combinations. Taking into consideration that early appearance of vascular dyscirculatory disorders observed in liquidators is the sign of early aging of the organism, geroprotectors were added to treatment schemes.

  12. [Experience of systematization on the treatment of patients with upper jaws fractures, during the period 1991-2000].

    PubMed

    Khinkov, D

    2005-01-01

    A retrospecive analysis was done of the 128 patients with fractures in a upper jaw, treated during the period 1991-2000. The treatment of the patients with partial fractures in a alveolar part of maxilla and frontal wall of maxillary sinus, consist of debridement on the open wound, primery stiched and stabilization by arch bar of perspective teeth. In the cases with fractures of tuber maxilla and opening of maxillary sinus they tray to clouse it by Rhermann technique, with or without radical antrothomy by Caldwell-Luc technique. On the patients by total upper jaw fractures they try lead by princip of duble stage fixation: from one side-of intact upper bone structures and the other side-on a mandible. On the cases of upper jaw fractures, combine with barain traums. was treated conservativly - the specialize treatment of facial injures was postpoun until stabilization of brain status.

  13. The optimal period of Ca-EDTA treatment for parthenogenetic activation of porcine oocytes during maturation culture

    PubMed Central

    MORITA, Yasuhiro; TANIGUCHI, Masayasu; TANIHARA, Fuminori; ITO, Aya; NAMULA, Zhao; DO, Lanh Thi Kim; TAKAGI, Mitsuhiro; TAKEMOTO, Tatsuya; OTOI, Takeshige

    2016-01-01

    The changes triggered by sperm-induced activation of oocytes, which are required for normal oocyte development, can be mediated by other agents, thereby inducing the parthenogenesis. In this study, we exposed porcine oocytes to 1 mM Ca-EDTA, a metal-ion chelator, at various intervals during 48 hr of in vitro maturation to determine the optimum period of Ca-EDTA treatment for parthenogenetic activation. When the oocytes were cultured with or without Ca-EDTA from 36 hr (post-12), 24 hr (post-24), 12 hr (post-36) and 0 hr (post-48) after the start of maturation culture, the blastocyst formation rates were significantly higher (P<0.05) in the post-24, post-36 and post-48 groups (3.3%, 4.0% and 2.6%, respectively) than those in the control group without treatment (0%). Furthermore, when the oocytes were cultured with Ca-EDTA for 0 hr (control), 12 hr (pre-12), 24 hr (pre-24), 36 hr (pre-36) and 48 hr (pre-48) from the start of maturation culture, the oocytes formed blastocysts only in the pre-36 and pre-48 groups (0.4% or 0.8%, respectively). Pronuclei (<66.7%) were observed only when the periods of Ca-EDTA treatment were more than 12 hr during maturation culture. In the control group, no pronuclei were detected. Our findings demonstrate that porcine immature oocytes can be parthenogenetically activated by Ca-EDTA treatment for at least 24 hr to 36 hr during maturation culture, leading to pronucleus formation followed by the formation of blastocysts. PMID:26947170

  14. Same-Day CD4 Testing to Improve Uptake of HIV Care and Treatment in South Africa: Point-of-Care Is Not Enough.

    PubMed

    Larson, Bruce A; Schnippel, Kathryn; Brennan, Alana; Long, Lawrence; Xulu, Thembi; Maotoe, Thapelo; Rosen, Sydney; Sanne, Ian; Fox, Matthew P

    2013-01-01

    Background. We evaluated whether a pilot program providing point-of-care (POC), but not rapid, CD4 testing (BD FACSCount) immediately after testing HIV-positive improved retention in care. Methods. We conducted a retrospective record review at the Themba Lethu Clinic in Johannesburg, South Africa. We compared all walk-in patients testing HIV-positive during February, July 2010 (pilot POC period) to patients testing positive during January 2008-February 2009 (baseline period). The outcome for those with a ≤250 cells/mm(3) when testing HIV-positive was initiating ART <16 weeks after HIV testing. Results. 771 patients had CD4 results from the day of HIV testing (421 pilots, 350 baselines). ART initiation within 16 weeks was 49% in the pilot period and 46% in the baseline period. While all 421 patients during the pilot period should have been offered the POC test, patient records indicate that only 73% of them were actually offered it, and among these patients only 63% accepted the offer. Conclusions. Offering CD4 testing using a point-of-care, but not rapid, technology and without other health system changes had minor impacts on the uptake of HIV care and treatment. Point-of-care technologies alone may not be enough to improve linkage to care and treatment after HIV testing.

  15. LH peak and ovulation after two different estrus synchronization treatments in buffalo cows in the daylight-lengthening period.

    PubMed

    Barile, V L; Terzano, G M; Pacelli, C; Todini, L; Malfatti, A; Barbato, O

    2015-07-15

    The aim of this study was to determine the timing of ovulation in relation to the LH peak after synchronization using PRID or Ovsynch protocols, to assess the effects of the period of treatment on these parameters and to provide information concerning how to use the two main protocols for fixed-time artificial insemination in buffalo. Forty-eight lactating Italian Mediterranean buffalo cows were used. The buffaloes were treated in various periods as follows: February to March (n = 12 PRID, n = 12 Ovsynch), end of the breeding season, May to June (n = 12 PRID, n = 12 Ovsynch), beginning of low-breeding season according to Italian environmental conditions. To determine the LH, blood samples were taken at 4-hour intervals, starting 24 hours from PRID removal (PRID group) or 12 hours from (PGF2α) injection (Ovsynch group) up to 108 hours. The ovaries were monitored by transrectal ultrasonography to verify ovulation. The LH-ovulation interval was similar in both groups (30.10 ± 1.05 and 32.77 ± 1.15 hours, respectively, in PRID and Ovsynch group). In the PRID group, the timing of ovulation in relation to device removal was 76.83 ± 3.65 hours with a high level of variability among the animals. In the Ovsynch group, we observed a better synchronization of LH peaks and ovulations, and the timing of ovulation in relation to the last GnRH injection was 35.67 ± 1.15 hours. The percentage of animals reaching the LH peak and ovulation was lower (P ≤ 0.05) in May to June (respectively 75.0% and 54.1%) compared to February to March (respectively 95.8% and 83.3%), indicating a reduction of hypothalamus-pituitary responsiveness to the synchronization treatments in the daylight-lengthening period. PMID:25958084

  16. LH peak and ovulation after two different estrus synchronization treatments in buffalo cows in the daylight-lengthening period.

    PubMed

    Barile, V L; Terzano, G M; Pacelli, C; Todini, L; Malfatti, A; Barbato, O

    2015-07-15

    The aim of this study was to determine the timing of ovulation in relation to the LH peak after synchronization using PRID or Ovsynch protocols, to assess the effects of the period of treatment on these parameters and to provide information concerning how to use the two main protocols for fixed-time artificial insemination in buffalo. Forty-eight lactating Italian Mediterranean buffalo cows were used. The buffaloes were treated in various periods as follows: February to March (n = 12 PRID, n = 12 Ovsynch), end of the breeding season, May to June (n = 12 PRID, n = 12 Ovsynch), beginning of low-breeding season according to Italian environmental conditions. To determine the LH, blood samples were taken at 4-hour intervals, starting 24 hours from PRID removal (PRID group) or 12 hours from (PGF2α) injection (Ovsynch group) up to 108 hours. The ovaries were monitored by transrectal ultrasonography to verify ovulation. The LH-ovulation interval was similar in both groups (30.10 ± 1.05 and 32.77 ± 1.15 hours, respectively, in PRID and Ovsynch group). In the PRID group, the timing of ovulation in relation to device removal was 76.83 ± 3.65 hours with a high level of variability among the animals. In the Ovsynch group, we observed a better synchronization of LH peaks and ovulations, and the timing of ovulation in relation to the last GnRH injection was 35.67 ± 1.15 hours. The percentage of animals reaching the LH peak and ovulation was lower (P ≤ 0.05) in May to June (respectively 75.0% and 54.1%) compared to February to March (respectively 95.8% and 83.3%), indicating a reduction of hypothalamus-pituitary responsiveness to the synchronization treatments in the daylight-lengthening period.

  17. [Establishment of the intestinal microflora and regulation of bacterial translocation after caffeine citrate treatment during postnatal period in rat].

    PubMed

    Moumen Chentouf, W; Tir Touil Meddah, A; Léké, A; Mullié, C; Krim, G; Canarelli, J-P; Meddah, B

    2012-10-01

    To relieve respiratory problems such as apnea in newborns, caffeine citrate is the drug of choice because of its good tolerance and therapeutic index. However, its impact on the intestinal microbial ecosystem and on bacterial translocation in the neonatal period remains insufficiently investigated. Therefore, the objective of this study was to evaluate the effects of caffeine citrate on the establishment of the intestinal microflora and bacterial translocation in rats from birth to the 30th day of life. Newborn Wistar rats were divided into four groups of 14 animals, each subdivided into a control group receiving a placebo (12mL tap water/kg/day) and another treated with caffeine citrate (12mg/kg/day). The animals were nursed by their mothers and weighed daily. A group of 14 rats was killed at birth and after 10, 20, or 30 days of life. Organs in which translocation was assessed (liver, lungs, spleen, and kidneys) and various fragments of intestine (duodenum, jejunum, ileum, and colon) were surgically removed. The bacteriological analysis performed involved enumeration of the total microflora, staphylococci, enterobacteria, and lactobacilli. From the 10th day, caffeine was shown to significantly decrease the weight of treated animals as compared with controls (P<0.05). However, caffeine treatment did not drastically alter the kinetics of establishment of the intestinal microflora as only enterobacteria were found to be significantly lower in any intestinal segment of the treated group (P<0.05). Moreover, from the 20th day of life, caffeine citrate significantly downregulated bacterial translocation of both Gram-positive and -negative bacteria (P<0.05). This preliminary study on the effects of treatment with caffeine citrate may open opportunities in clinical pediatrics; the treatment will remain partially effective in preventing bacterial translocation in the neonatal period. PMID:22920890

  18. Planetary populations in the mass-period diagram: A statistical treatment of exoplanet formation and the role of planet traps

    SciTech Connect

    Hasegawa, Yasuhiro; Pudritz, Ralph E. E-mail: pudritz@physics.mcmaster.ca

    2013-11-20

    The rapid growth of observed exoplanets has revealed the existence of several distinct planetary populations in the mass-period diagram. Two of the most surprising are (1) the concentration of gas giants around 1 AU and (2) the accumulation of a large number of low-mass planets with tight orbits, also known as super-Earths and hot Neptunes. We have recently shown that protoplanetary disks have multiple planet traps that are characterized by orbital radii in the disks and halt rapid type I planetary migration. By coupling planet traps with the standard core accretion scenario, we showed that one can account for the positions of planets in the mass-period diagram. In this paper, we demonstrate quantitatively that most gas giants formed at planet traps tend to end up around 1 AU, with most of these being contributed by dead zones and ice lines. We also show that a large fraction of super-Earths and hot Neptunes are formed as 'failed' cores of gas giants—this population being constituted by comparable contributions from dead zone and heat transition traps. Our results are based on the evolution of forming planets in an ensemble of disks where we vary only the lifetimes of disks and their mass accretion rates onto the host star. We show that a statistical treatment of the evolution of a large population of planetary cores caught in planet traps accounts for the existence of three distinct exoplanetary populations—the hot Jupiters, the more massive planets around r = 1 AU, and the short-period super-Earths and hot Neptunes. There are very few populations that feed into the large orbital radii characteristic of the imaged Jovian planet, which agrees with recent surveys. Finally, we find that low-mass planets in tight orbits become the dominant planetary population for low-mass stars (M {sub *} ≤ 0.7 M {sub ☉}).

  19. Fall in incidence of guinea-worm infection in western Nigeria after periodic treatment of infected persons.

    PubMed

    Kale, O O

    1982-01-01

    Between 1971 and 1974 a series of drug trials was conducted in 17 rural communities in western Nigeria where guinea-worm is endemic. During these trials and in subsequent years treatment, in the form of chemotherapy and/or dressing of ulcers, was given to all infected persons. A longitudinal study of infection in these villages showed a marked fall in the annual incidence over an 8-year period. The aggregate reduction in incidence in the three sectors surveyed was from 15.5% to 0.5% in sector 1, 29.8% to 0.4% in sector 2, and 20.3% to 0.0% in sector 3. The change appeared to be partly due to the treatment, which reduced the reservoir of infection and the rate of pollution of the water supply. Most of the sources of water continued to harbour Cyclops, none of which was found to be infected with Dracunculus, but which were shown experimentally to be capable of sustaining infection. The study demonstrates the potential role of therapeutic measures in controlling guinea-worm infection. It is suggested that the satisfactory measure of control that has been achieved could be increased by elimination of the Cyclops, with a view to total eradication of the disease from affected communities. Attention is drawn to the relevance of the findings for the International Drinking Water Supply and Sanitation Decade.

  20. Epogam evening primrose oil treatment in atopic dermatitis and asthma.

    PubMed

    Hederos, C A; Berg, A

    1996-12-01

    Essential fatty acids are claimed to have positive effects in atopic diseases. In a double blind, placebo controlled, parallel group study 58 out of 60 children, with atopic dermatitis and the need for regular treatment with topical skin steroids, completed a 16 weeks' treatment period with either Epogam evening primrose oil or placebo capsules. Twenty two of these subjects also had asthma. The parents used diaries to record symptom scores and concomitant medication. Peak expiratory flow was measured and disease activity was monitored by the clinician every four weeks. The plasma concentrations of essential fatty acids increased significantly in the group treated with Epogam capsules. The study demonstrated significant improvements of the eczema symptoms but no significant difference was found between the placebo and the Epogam groups. No therapeutic effect was shown on asthma symptoms or fidget.

  1. A conditional analysis for two-treatment multiple-period crossover designs with binomial or poisson outcomes and subjects who drop out.

    PubMed

    McKnight, B; Van den Eeden, S K

    1993-05-15

    We propose a conditional analysis for outcome data on numbers of recurrent symptoms arising in a two-treatment, multiple-period crossover trial. Conditioning on subject-specific totals removes any dependence on mean subject-specific symptom rates and permits the use of standard software to perform regression analysis to examine treatment, period, carryover and interaction effects. The addition of offsets to the regression equations allows the incorporation of data from subjects who do not complete all periods in the trial. We apply the proposed method to data from a crossover trial and discuss its advantages and disadvantages.

  2. Evaluation of partial arytenoidectomy as a treatment for equine laryngeal hemiplegia.

    PubMed

    Lumsden, J M; Derksen, F J; Stick, J A; Robinson, N E; Nickels, F A

    1994-03-01

    The efficacy of partial arytenoidectomy was assessed in 6 Standardbred horses, with surgically induced laryngeal hemiplegia, at rest (Period A) and during exercise at speeds corresponding to maximum heart rate (Period C) and 75% of maximum heart rate (Period B). Peak expiratory and inspiratory airflow rate (PEF and PIF), and expiratory and inspiratory transupper airway pressure (PUE and PUI) were measured and expiratory and inspiratory impedance (ZE and ZI) were calculated. Simultaneously, tidal breathing flow-volume loops (TBFVL) were acquired using a respiratory function computer. Indices derived from TBFVL included airflow rates at 50 and 25% of tidal volume (EF50, IF50, EF25, and IF25) and the ratios of expiratory to inspiratory flows. Measurements were made before left recurrent laryngeal neurectomy (baseline), 2 weeks after left recurrent laryngeal neurectomy (LRLN) and 16 weeks after left partial arytenoidectomy coupled with bilateral ventriculectomy (ARYT). After LRLN, during exercise Periods B and C, Z1 and the ratio of EF50/IF50 significantly increased and PIF, IF50 and IF25 significantly decreased from baseline values. At 16 weeks after ARYT, Z1 returned to baseline values during Periods B and C. Although PIF, IF50, IF25, PEF/PIF, and EF50/IF50 returned to baseline values during Period B, these indices remained significantly different from baseline measurements during Period C. After ARYT, TBFVL shapes from horses during Period C approached that seen at the baseline evaluation. Partial arytenoidectomy improved upper airway function in exercising horses with surgically induced left laryngeal hemiplegia, although qualitative and quantitative evaluation of TBFVLs suggested that some flow limitation remains at near maximal airflow rates. These results indicate that, although the procedure does not completely restore the upper airway to normal, partial arytenoidectomy is a viable treatment option for failed laryngoplasty and arytenoid chondropathy in the

  3. Differential efficacy of treatment with acetylcholinesterase inhibitors in patients with mild and moderate Alzheimer's disease over a 6-month period.

    PubMed

    López-Pousa, S; Turon-Estrada, A; Garre-Olmo, J; Pericot-Nierga, I; Lozano-Gallego, M; Vilalta-Franch, M; Hernández-Ferràndiz, M; Morante-Muñoz, V; Isern-Vila, A; Gelada-Batlle, E; Majó-Llopart, J

    2005-01-01

    There are various anticholinesterase inhibitors (AChEIs) for the symptomatic treatment of mild to moderate Alzheimer's disease (AD). All AChEIs have shown greater efficacy than placebo in randomized, double-blind, parallel-group clinical trials. No differential studies have yet been made of the efficacy between all AChEIs. The study aims to determine the differential efficacy of the AChEIs with respect to a historical sample of patients with AD that were not treated with AChEIs. An open-label, prospective, observational study with a retrospective control group was undertaken to examine the evolution of the cognitive function over a 6-month period. The patients were assessed with the Mini-Mental State Examination (MMSE) at study entry and at 6 months. A general linear model was applied for repeated measurements with the MMSE score as the dependent variable, treatment type as an independent variable and the severity of the deterioration, age and the MMSE baseline score as covariables. Of the sample of 147 patients, 40 initiated treatment with donepezil, 32 with galantamine, 30 with rivastigmine and 45 were part of a historical sample of the memory clinic patients between 1991 and 1996 that had not been treated with AChEIs. The average age was 73.7 years (SD = 6.9; range = 52-86), 67.3% were women, 78.2% of the cases were mild and the MMSE baseline score was 18.1 points (range = 11-27). No significant intergroup differences were observed in these variables. The average doses of donepezil, galantamine and rivastigmine were 5.87 mg/day (SD = 1.92), 14.81 mg/day (SD = 6.25) and 6.41 mg/day (SD = 1.82), respectively. At 6 months, the difference in the MMSE score with respect to the untreated group was 1.6 points for donepezil (95% CI 0.79-2.37; p < 0.001), 0.99 points for galantamine (95% CI 0.14-1.85; p = 0.01) and 0.90 points for rivastigmine (95% CI 0.05-1.74; p = 0.03). No significant differences were observed in the efficacy among the groups treated with AChEIs (p

  4. Familial Periodic Paralyses

    MedlinePlus

    ... NINDS NINDS Familial Periodic Paralyses Information Page Synonym(s): Periodic Paralyses Table of Contents (click to jump to sections) What are Familial Periodic Paralyses? Is there any treatment? What is the ...

  5. ASSESSING THE IMPACT OF CONTINUOUS BACTERIAL TREATMENTS OVER A TWO-WEEK PERIOD ON ZEBRA MUSSEL MORTALITY

    SciTech Connect

    Daniel P. Molloy

    2001-07-17

    These experiments indicated that in waters at 23 C the window of opportunity to kill zebra mussels with bacterial strain CL0145A is limited to the first two days of treatment. Treatments beyond two days will not increase mortality.

  6. Renewable Energy in Water and Wastewater Treatment Applications; Period of Performance: April 1, 2001--September 1, 2001

    SciTech Connect

    Argaw, N.

    2003-06-01

    This guidebook will help readers understand where and how renewable energy technologies can be used for water and wastewater treatment applications. It is specifically designed for rural and small urban center water supply and wastewater treatment applications. This guidebook also provides basic information for selecting water resources and for various kinds of commercially available water supply and wastewater treatment technologies and power sources currently in the market.

  7. [Possibilities of magnetic-laser therapy in comprehensive treatment of patients with brain concussion in acute period].

    PubMed

    Zubkova, O V; Samosiuk, I Z; Polishchuk, O V; Shul'ga, N M; Samosiuk, N I

    2012-01-01

    The efficacy of magnetic-laser therapy used according to the method developed by us was studied in patients having the brain concussion (BC) in an acute period. The study was based on the dynamics of values of the evoked vestibular potentials and the disease clinical course. It was shown that following the magnetic-laser therapy in combination with traditional pharmacotherapy in BC acute period, the statistically significant positive changes were registered in the quantitative characteristics of the evoked vestibular brain potentials that correlated with the dynamics of the disease clinical course. The data obtained substantiate the possibility of using the magnetic-laser therapy in patients with a mild craniocereblal injury in an acute period.

  8. A Collaborative Care Telemedicine Intervention to Overcome Treatment Barriers for Latina Women with Depression during the Perinatal Period

    PubMed Central

    Baker-Ericzén, Mary J.; Connelly, Cynthia D.; Hazen, Andrea L.; Dueñas, Cecilia; Landsverk, John A.; Horwitz, Sarah McCue

    2013-01-01

    Maternal depression is highly prevalent (10 to 20%) during the perinatal period with rates as high as 35 to 40% for Latinas. However, few Latinas are either identified or treated during the perinatal period. To address these disparities, the Perinatal Mental Health Model (PMH) was designed to ameliorate the barriers that prevent adequate diagnoses and intervention. The PMH is a culturally sensitive, short-term telemedicine, and collaborative care intervention for addressing depression among Mexican American mothers. It attends to sociocultural and socioeconomic dimensions and is delivered by trained mental health advisors within obstetric care settings. This article describes the feasibility and acceptability of utilizing the PMH. Participants (n=79) were selected from a first year ongoing randomized trial in community obstetric clinics. The intervention seems feasible and acceptable; low-income Latinas, identified as depressed during the perinatal period, reported having access to a range of appropriate community services and high satisfaction. PMID:22709321

  9. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

    PubMed Central

    Cleveland, W. Louis; DeLaPaz, Robert L.; Fawwaz, Rashid A.; Challop, Roger S.

    2009-01-01

    This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A β-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD. PMID:20182547

  10. 26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., assume that X is a regulated investment company that computes its income on a calendar year basis, and that no election is in effect under section 4982(e)(4). Example 1. X has a $25 net foreign currency... period of 1988. X has no post-October currency loss and no post-October capital loss for 1988, and...

  11. Rapid Response to Treatment for Binge Eating Disorder

    ERIC Educational Resources Information Center

    Grilo, Carlos M.; Masheb, Robin M.; Wilson, Terence G.

    2006-01-01

    The authors examined rapid response among 108 patients with binge eating disorder (BED) who were randomly assigned to 1 of 4 16-week treatments: fluoxetine, placebo, cognitive-behavioral therapy (CBT) plus fluoxetine, or CBT plus placebo. Rapid response, defined as 65% or greater reduction in binge eating by the 4th treatment week, was determined…

  12. Correlates of satisfaction with pain treatment in the acute postoperative period: results from the international PAIN OUT registry.

    PubMed

    Schwenkglenks, Matthias; Gerbershagen, Hans J; Taylor, Rod S; Pogatzki-Zahn, Esther; Komann, Marcus; Rothaug, Judith; Volk, Thomas; Yahiaoui-Doktor, Maryam; Zaslansky, Ruth; Brill, Silviu; Ullrich, Kristin; Gordon, Debra B; Meissner, Winfried

    2014-07-01

    Patient ratings of satisfaction with their postoperative pain treatment tend to be high even in those with substantial pain. Determinants are poorly understood and have not previously been studied in large-scale, international datasets. PAIN OUT, a European Union-funded acute pain registry and research project, collects patient-reported outcome data on postoperative day 1 using the self-reported International Pain Outcome Questionnaire (IPO), and patient, clinical, and treatment characteristics. We investigated correlates of satisfaction and consistency of effects across centres and countries using multilevel regression modelling. Our sample comprised 16,868 patients (median age 55 years; 55% female) from 42 centres in 11 European countries plus Israel, USA, and Malaysia, who underwent a wide range of surgical procedures, for example, joint, limb, and digestive tract surgeries. Median satisfaction was 9 (interquartile range 7-10) on a 0-10 scale. Three IPO items showed strong associations and explained 35% of the variability present in the satisfaction variable: more pain relief received, higher allowed participation in pain treatment decisions, and no desire to have received more pain treatment. Patient factors and additional IPO items reflecting pain experience (eg, worst pain intensity), pain-related impairment, and information on pain treatment added little explanatory value, partially due to covariate correlations. Effects were highly consistent across centres and countries. We conclude that satisfaction with postoperative pain treatment is associated with the patients' actual pain experience, but more strongly with impressions of improvement and appropriateness of care. To the degree they desire, patients should be provided with information and involved in pain treatment decisions. PMID:24785269

  13. 26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Treatment of certain losses attributable to... that no election is in effect under section 4982(e)(4). Example 1. X has a $25 net foreign currency...) 100 01/01 to 10/31/89 30 40 (5) (20) 25 20 11/01 to 12/31/89 35 100 (0) (50) 35 50 X has a...

  14. 26 CFR 1.852-11 - Treatment of certain losses attributable to periods after October 31 of a taxable year.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Treatment of certain losses attributable to... that no election is in effect under section 4982(e)(4). Example 1. X has a $25 net foreign currency...) 100 01/01 to 10/31/89 30 40 (5) (20) 25 20 11/01 to 12/31/89 35 100 (0) (50) 35 50 X has a...

  15. Homeopathic treatment of elderly patients - a prospective observational study with follow-up over a two year period

    PubMed Central

    2010-01-01

    Background Very little is known about the range of diagnoses, course of treatment and long-term outcome in elderly patients who choose to receive homeopathic medical treatment. We investigated homeopathic practice in an industrialised country under everyday conditions. The aim of the study was to determine the spectrum of diagnoses and treatments, as well as to describe the course of illness over time among older patients who chose to receive homeopathic treatment. Methods In this subgroup analysis of a prospective, multicentre cohort study totally including 3981 patients treated by homeopathic physicians in primary care practices in Germany and Switzerland, data was analysed from all patients > 70 years consulting the physician for the first time. The main outcome measures were: assessment by patient of the severity of complaints (numeric rating scales) and quality of life (SF-36) and by the physician of the severity of diagnoses (numeric rating scales) at baseline, and after 3, 12, and 24 months. Results A total of 83 patients were included in the subgroup analysis (41% men, mean age 73.2 ± (SD) 3.1 years; 59% women, 74.3 ± 3.8 years). 98.6 percent of all diagnoses were chronic with an average duration of 11.5 ± 11.5 years. 82 percent of the patients were taking medication at baseline. The most frequent diagnoses were hypertension (20.5%, 11.1 ± 7.5 years) and sleep disturbances (15.7%, 22.1 ± 25.8 years). The severity of complaints decreased significantly between baseline and 24 months in both patients (from 6.3 (95%CI: 5.7-6.8) to 4.6 (4.0-5.1), p < 0.001) and physicians' assessments (from 6.6 (6.0-7.1) to 3.7 (3.2-4.3), p < 0.001); quality of life (SF 36) and the number of medicines taken did not significantly change. Conclusion The severity of disease showed marked and sustained improvements under homeopathic treatment, but this did not lead to an improvement of quality of life. Our findings might indicate that homeopathic medical therapy may play a

  16. [Prevention and treatment of pressure sores--a neglected research subject? An overview of clinically controlled studies in the period 1987-91].

    PubMed

    Tewes, M

    1993-01-01

    Pressure sores are frequently seen in elderly hospitalized patients and leads to prolonged hospitalization and increased morbidity and mortality. The object of this paper was to retrieve the last five years literature regarding prevention and treatment of pressure sores. During the period 1987-1991, 751 papers on this topic were published and indexed in Medline. Only 9 of these papers represented controlled clinical trials. Three of them dealt with prevention, and the remaining 6 with treatment. Although 4 of 9 studies showed statistically significant differences between the actively treated group and the placebo group, none of the studies showed convincing clinical differences. Serious methodological flaws with respect to design, blinding, randomisation, sample size and statistical analysis were found in 8 of 9 studies. None of the clinical controlled studies on prevention of pressure sores showed any statistically significant differences between the control group and treatment with, respectively Prevasore lotion, Foam cushion and Silicore mattress. In the 6 trials on treatment of pressure sores, respectively mucopolysaccharide polysulphate creme, ketanserin creme and air-fluidized beds showed statistically better results than control treatment. We conclude that well-designed controlled clinical trials are needed to establish rational routines for prevention and treatment of pressure sores.

  17. Time Trends of Cannabis Use Among Treatment-seeking Individuals at Government De-addiction Centers Across India Over a Period of 7 Years

    PubMed Central

    Balhara, Yatan Pal Singh; Mishra, Ashwani; Sethi, Hem; Singh, Shalini; Khandelwal, Sudhir Kumar

    2016-01-01

    Background: Cannabis continues to be the most commonly used illicit psychoactive substance globally. The National Survey in India conducted in the year 2004 also reported it to be the most commonly used illicit substance in the country. Furthermore, it was reported to be the second most commonly used psychoactive substance by the treatment seekers at de-addiction centers in the country. Objectives: To assess time trends of cannabis use among treatment-seeking individuals at government de-addiction centers across India over a period of 7 years. Materials and Methods: The study utilized data collected through Drug Abuse Monitoring System across India. The data of treatment seekers from de-addiction centers established under the Drug De-addiction Program, Ministry of Health and Family Welfare, Government of India and supported by the Ministry of Social Justice and Empowerment, Government of India (122 in number) across the country were analyzed. Results: A total of 107,469 individuals sought treatment from government de-addiction centers over the 7 years (2007–2013) period. With the exception of an aberration for the year 2012, there has been a steady decline in the proportion of treatment seekers who are not current cannabis users. A significantly greater proportion (Chi-square: 586.30, df: 1, P < 0.001) of individuals with current cannabis use alone or along with tobacco (20.4%) tend to have a co-morbid psychiatric disorder as compared to treatment seekers with current use of substances other than cannabis (6.1%). Conclusions: It is important to focus on cannabis in clinical service delivery and research in the country. PMID:27570345

  18. Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment

    PubMed Central

    Xi, Yang; Li, Lei; Duffield, Giles E.

    2012-01-01

    Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1luc or PER2LUC) and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2LUC, but not per1luc is rhythmic in atrial tissue, while both per1luc and PER2LUC exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1luc and PER2LUC bioluminescence amplitudes were increased in response to DEX treatment, and the PER2LUC amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue. PMID:23110090

  19. Biomineralization of azo dye bearing wastewater in periodic discontinuous batch reactor: Effect of microaerophilic conditions on treatment efficiency.

    PubMed

    Naresh Kumar, A; Nagendranatha Reddy, C; Venkata Mohan, S

    2015-01-01

    The present study illustrates the influence of microaerophilic condition on periodic discontinuous batch reactor (PDBR) operation in treating azo dye containing wastewater. The process performance was evaluated with the function of various dye load operations (50-750 mg/l) by keeping the organic load (1.6 kg COD/m(3)-day) constant. Initially, lower dye operation (50mg dye/l) resulted in higher dye [45 mg dye/l (90%)] and COD [SDR: 1.29 kg COD/m(3)-day (92%)] removal efficiencies. Higher dye load operation (750 mg dye/l) also showed non-inhibitory performance with respect to dye [600 mg dye/l (80%)] and COD [1.25 kg COD/m(3)-day (80%)] removal efficiencies. Increment in dye load showed increment in azo reductase and dehydrogenase activities (39.6 U; 4.96 μg/ml; 750 mg/l). UV-Vis spectroscopy (200-800 nm), FTIR and (1)H NMR studies revealed the disappearance of azo bond (-NN-). First derivative cyclic voltammogram supported the involvement of various membrane bound redox shuttlers, viz., cytochrome-C, cytochrome-bc1 and flavoproteins (FAD (H)).

  20. Administration of Mycobacterium phlei cell wall-nucleic acid complex in the immediate postoperative period for the treatment of non-muscle-invasive bladder cancer

    PubMed Central

    Morales, Álvaro

    2016-01-01

    Introduction: This review sought to investigate the safety of intravesical administration of Mycobacterium phlei cell wall-nucleic acid (MCNA) in the immediate postoperative period after biopsy/resection for non-muscle-invasive bladder cancer (NMIBC). Methods: Patients with NMIBC who failed bacillus Calmette-Guérin (BCG) therapy and at high risk of recurrence and progression participated in this study. Treatment involved an induction phase of six weeks and maintenance of three weekly instillations every six months for two years. Biopsies were mandatory at six months and resections/biopsies as indicated. Of the 129 patients enrolled, 18 (14%) received one or more instillations of MCNA within 24 hours of an endoscopic procedure for a total of 32 instillations. Results: Fourteen patients (78%) received MCNA in the immediate postoperative period. Two (11%) received treatment the day after surgery, but a second treatment immediately after a transurethral resection of the bladder tumour (TURBT). The remaining two patients received an instillation each the day after surgery. Adverse events (AEs) occurred in 31.3% of those treated immediately after the procedure; they were mild, limited to the lower urinary tract, and not drug-related. Only one patient experienced systemic symptoms of moderate severity. None of the AEs resulted in postponement of treatment. There were no AEs among those receiving MCNA the day after surgery. Conclusions: The dual mechanism of action of MCNA suggests that early treatment would take advantage of its chemotherapeutic (pro-apoptotic) activity. Concerns about early administration due to the presence of live bacteria are circumvented with this sterile preparation. These preliminary results warrant further investigation to confirm the safety of perioperative administration of MCNA. PMID:27800054

  1. Induction of anoxic microenvironment in multi-phase metabolic shift strategy during periodic discontinuous batch mode operation enhances treatment of azo dye wastewater.

    PubMed

    Nagendranatha Reddy, C; Naresh Kumar, A; Annie Modestra, J; Venkata Mohan, S

    2014-08-01

    Variation in anoxic microenvironment (multi-phase (MP) metabolic shift strategy) during cycle operation of periodic discontinuous batch/sequencing batch (PDBR/SBR) mode operation showed enhanced degradation of recalcitrant azo dye (C.I. Acid Black 10B) at higher dye load (1250mg/l). The process performance was evaluated by varying anoxic phasing period during cycle operation. Before multiphase (BMP) operation with 2.1% of anoxic period showed color/COD removal efficiency of 41.9%/46.3%. Increment in anoxic period responded favorable in enhancing treatment efficiency [AMPI (16.2%), 49.4%/52.4%; AMPII (26.6%), 54.7%/57.2%; AMPIII (34.9%), 58.4%/61.5%]. Relatively higher bio-electrochemical activity, persistent reductive behavior (redox catalytic currents, 0.26/-0.72μA), prevalence of redox shuttlers (Fe-S proteins, cytochromes, quinones) facilitating enhanced electron transfer by minimization of associated losses and higher enzyme activities were observed with induction of anoxic phase. Anoxic condition shifts system microenvironment between oxidation and reduction assisting reduction of dye to its intermediates followed by their mineralization.

  2. Adiabatic properties of pulsating DA white dwarfs. I - The treatment of the Brunt-Vaisala frequency and the region of period formation

    NASA Technical Reports Server (NTRS)

    Brassard, P.; Fontaine, G.; Wesemael, F.; Kawaler, S. D.; Tassoul, M.

    1991-01-01

    The fundamental issue of the region of period formaton in a degenerate star is examined, with special attention given to the treatment of the Brunt-Vaisala frequency. It is shown that, in order to obtain reliable numerical results in degenerate stellar models, the Brunt-Vaisala frequency must be appropriately transformed, because it is defined in terms of a difference between two numbers which become nearly equal in highly degenerate matter, causing serious numerical problems and systematic errors. An alternative expression is derived, which is valid for multicomponent nonideal partially degenerate and partially ionized plasmas such as those encountered in white dwarf envelopes. This expression is used to compute the period structure of the same white dwarf considered by Pesnell (1987). It is shown that the implicit numerical differencing used in the Lagrangian pulsation code of Pesnell leads to very serious difficulties when used with models of degenerate stars.

  3. Case report: Successful treatment of recurrent chordoma and bilateral pulmonary metastases following an 11-year disease-free period

    PubMed Central

    Erkmen, Cherie P.; Barth, Richard J.; Raman, Vignesh

    2014-01-01

    INTRODUCTION Chordomas are rare but aggressive tumors due to local recurrence and distant metastases. They originate commonly in the sphenooccipital and sacrococcygeal regions, and metastasize to the lungs, bone, skin, liver, and lymph nodes. They occur more frequently in men and people over the age of 40. PRESENTATION OF CASE A 28 year-old female presented with sacrococcygeal chordoma for which she received wide local excision and adjuvant radiation therapy. She enjoyed an unusual disease-free survival for 11 years until a routine surveillance scan of the pelvis identified local recurrence. Further work up revealed bilateral pulmonary metastases. She underwent local excision of the recurrent tumor and video-assisted thoracoscopic (VATS) wedge resection of pulmonary metastases. She also received adjuvant radiation therapy to the recurrent resection bed. Two years later, she remains free of disease and symptoms. DISCUSSION Chordomas are commonly insensitive to chemotherapy and radiation, making surgery the most successful therapeutic modality. However, there are few guidelines on the surveillance and treatment of recurrent chordoma. We report success with aggressive surgical resection of recurrence and metastasis as well as adjuvant radiation therapy. CONCLUSION The prolonged survival of our patient underscores the importance of (1) aggressive surgical resection of chordoma, whether primary, recurrent, or metastatic, with adjuvant radiation therapy, (2) minimization of surgical seeding of tumor, and (3) diligent cancer surveillance. PMID:24907541

  4. Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through an One-Year Period

    PubMed Central

    Gkini, Maria-Angeliki; Kouskoukis, Alexandros-Efstratios; Tripsianis, Gregory; Rigopoulos, Dimitris; Kouskoukis, Konstantinos

    2014-01-01

    Background: Platelet-rich plasma (PRP) is defined as an autologous concentration of plasma with a greater count of platelets than that of whole blood. Its action depends on the released growth factors from platelets. It has been investigated and used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss. Aims: To evaluate the efficacy and safety of PRP injections in the scalp of patients with androgenetic alopecia. Settings and Design: Prospective cohort study. Materials and Methods: 20 patients, 18 males and 2 females, with androgenetic alopecia were enrolled in the study. PRP was prepared using a single spin method (Regenlab SA). Upon activation, it was injected in the androgen-related areas of scalp. Three treatment sessions were performed with an interval of 21 days and a booster session at 6 months following the onset of therapy. Statistical Analysis: Statistical analysis of the data was performed using the Statistical Package for the Social Sciences (SPSS), version 19.0 (IBM, NY, USA). Results: Hair loss reduced and at 3 months it reached normal levels. Hair density reached a peak at 3 months (170.70 ± 37.81, P < 0.001). At 6 months and at 1 year, it was significantly increased, 156.25 ± 37.75 (P < 0.001) and 153.70 ± 39.92 (P < 0.001) respectively, comparing to baseline. Patients were satisfied with a mean result rating of 7.1 on a scale of 1-10. No remarkable adverse effects were noted. Conclusions: Our data suggest that PRP injections may have a positive therapeutic effect on male and female pattern hair loss without remarkable major side effects. Further studies are needed to confirm its efficacy. PMID:25722600

  5. Personality, Stressful Life Events, and Treatment Response in Major Depression

    ERIC Educational Resources Information Center

    Bulmash, Eric; Harkness, Kate L.; Stewart, Jeremy G.; Bagby, R. Michael

    2009-01-01

    The current study examined whether the personality traits of self-criticism or dependency moderated the effect of stressful life events on treatment response. Depressed outpatients (N = 113) were randomized to 16 weeks of cognitive-behavioral therapy, interpersonal psychotherapy, or antidepressant medication (ADM). Stressful life events were…

  6. The effects of bright-light therapy on actigraphical measured sleep last for several weeks post-treatment. A study in a nursing home population.

    PubMed

    Fetveit, Arne; Bjorvatn, Bjørn

    2004-06-01

    We investigated the time-course of nocturnal actigraphic measures, following the termination of bright-light therapy for sleep disturbances in demented nursing home patients. From an earlier study, 11 nursing home patients (86 +/- 9 years, Mini-Mental Status Examination score 12 +/- 4) with actigraphically measured sleep efficiency < 85%, were recruited to morning bright-light treatment (6000-8000 lux) 2 h per day for 14 days. Actigraphic measures were registered at pretreatment, treatment and at four monthly post-treatment periods. Each actigraphic recording period consisted of seven consecutive days. Sleep improved substantially with treatment; sleep efficiency increased from 73% to 86% and total nocturnal wake time was reduced by nearly 2 h. During the 16 weeks post-treatment period, actigraphic measures gradually returned to pretreatment levels. Sleep efficiency remained significantly higher than the pretreatment level 4 weeks after treatment termination. Sleep onset latency remained significantly reduced up until 12 weeks post-treatment. This study supports previous findings of beneficial effects of bright-light therapy for sleep disturbances in demented nursing home patients. Furthermore, these results are the first to suggest that post-treatment effects of short-term bright-light therapy may last longer than previously assumed. PMID:15175095

  7. Comparison of different combined treatment processes to address the source water with high concentration of natural organic matter during snowmelt period.

    PubMed

    Lin, Pengfei; Zhang, Xiaojian; Wang, Jun; Zeng, Yani; Liu, Shuming; Chen, Chao

    2015-01-01

    The source water in one forest region of the Northeast China had very high natural organic matter (NOM) concentration and heavy color during snowmelt period. The efficiency of five combined treatment processes was compared to address the high concentration of NOM and the mechanisms were also analyzed. Conventional treatment can hardly remove dissolved organic carbon (DOC) in the source water. KMnO4 pre-oxidization could improve the DOC removal to 22.0%. Post activated carbon adsorption improved the DOC removal of conventional treatment to 28.8%. The non-sufficient NOM removal could be attributed to the dominance of large molecular weight organic matters in raw water, which cannot be adsorbed by the micropore upon activated carbon. O3+activated carbon treatment are another available technology for eliminating the color and UV254 in water. However, its performance of DOC removal was only 36.4%, which could not satisfy the requirement for organic matter. The limited ozone dosage is not sufficient to mineralize the high concentration of NOM. Magnetic ion-exchange resin combined with conventional treatment could remove 96.2% of color, 96.0% of UV254 and 87.1% of DOC, enabling effluents to meet the drinking water quality standard. The high removal efficiency could be explained by the negative charge on the surface of NOM which benefits the static adsorption of NOM on the anion exchange resin. The results indicated that magnetic ion-exchange resin combined with conventional treatment is the best available technology to remove high concentration of NOM.

  8. Effect of 23-Valent Pneumococcal Polysaccharide Vaccine Inoculated During Anti-Cancer Treatment Period in Elderly Lung Cancer Patients on Community-Acquired Pneumonia Hospitalization

    PubMed Central

    Chiou, Wen-Yen; Hung, Shih-Kai; Lai, Chun-Liang; Lin, Hon-Yi; Su, Yu-Chieh; Chen, Yi-Chun; Shen, Bing-Jie; Chen, Liang-Cheng; Tsai, Shiang-Jiun; Lee, Moon-Sing; Li, Chung-Yi

    2015-01-01

    Abstract To evaluate effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) inoculated during defined “vaccination period,” first 6 months post cancer diagnosis (ie, an anti-cancer treatment period), in elderly lung cancer patients on community-acquired pneumonia (CAP) hospitalization incidence. This was a nationwide population-based cohort study of 157 newly diagnosed elderly lung cancer patients receiving PPSV23 during “vaccination period”, and 628 age and sex one-to-one matched controls enrolled in the National Health Insurance Research Database (NHIRD) of Taiwan between 2007 and 2010. All patients were ≥75 years old and still survival post “vaccination period.” Incidence density (ID) of all-cause inpatient CAP and cumulative survival risk were analyzed by multivariate Poisson regression and Kaplan–Meier method, respectively. After a 4-year follow-up, IDs of all-cause inpatient CAP for vaccination and control cohorts were 297 and 444 per 1000 PYs, respectively. Less vaccinated patients had CAP incidence density >1 time per PY (12.7% vs 21.2%) than non-vaccinated patients. After adjusting for potential confounding variables, like influenza vaccination, comorbidities, cancer treatment modalities, and socioeconomic status, adjusted inpatient CAP incidence rate in PPSV23 vaccination cohort was 0.74 times lower than control cohort (incidence rate ratio [IRR] = 0.740, P = 0.0339). Two-year cumulative CAP hospitalization rates and overall survival rates were 37.1% vs. 55.4%, and 46.6% vs. 26.2%, respectively, for lung cancer patients with and without PPSV23 (both P < 0.001). Subgroup analysis showed that for elderly lung cancer patients not ever receiving influenza vaccine, PPSV23 still had trend to reduce all-cause inpatient CAP. For elderly lung cancer patients aged ≥75 years, PPSV23 inoculated during anti-cancer treatment period could reduce CAP hospitalizations and improve survival. PMID:26131806

  9. Childhood Maltreatment and Differential Treatment Response and Recurrence in Adult Major Depressive Disorder

    ERIC Educational Resources Information Center

    Harkness, Kate L.; Bagby, R. Michael; Kennedy, Sidney H.

    2012-01-01

    Objective: A substantial number of patients with major depressive disorder (MDD) do not respond to treatment, and recurrence rates remain high. The purpose of this study was to examine a history of severe childhood abuse as a moderator of response following a 16-week acute treatment trial, and of recurrence over a 12-month follow-up. Method:…

  10. Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment

    ERIC Educational Resources Information Center

    Ventola, Pamela E.; Yang, Daniel; Abdullahi, Sebiha M.; Paisley, Courtney A.; Braconnier, Megan L.; Sukhodolsky, Denis G.

    2016-01-01

    Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD…

  11. Alliance in Two Telephone-Administered Treatments: Relationship with Depression and Health Outcomes

    ERIC Educational Resources Information Center

    Beckner, Victoria; Vella, Lea; Howard, Isa; Mohr, David C.

    2007-01-01

    The present study examined the relationship between therapeutic alliance and both depression and health outcomes in a randomized clinical trial of 2 telephone-administered treatments with 97 clients with multiple sclerosis (MS). The 16-week, manualized treatments compared were telephone-administered cognitive-behavioral therapy (T-CBT) and…

  12. Irregular Periods

    MedlinePlus

    ... number of days after the last one. The Menstrual Cycle Most girls get their first period between the ... to skip periods or to have an irregular menstrual cycle. Illness, rapid weight change, or stress can also ...

  13. Comparison of (6 S)-5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults.

    PubMed

    Wright, Anthony J A; King, Maria J; Wolfe, Caroline A; Powers, Hilary J; Finglas, Paul M

    2010-03-01

    Folic acid (pteroylmonoglutamic acid) has historically been used as the reference folate in human intervention studies assessing the relative bioavailability of dietary folate. Recent studies using labelled folates indicated different plasma response kinetics to folic acid than to natural (food) folates, thus obviously precluding its use in single-dose experiments. Since differences in tissue distribution and site of biotransformation were hypothesised, the question is whether folic acid remains suitable as a reference folate for longer-term intervention studies, where the relative bioavailability of natural (food) folate is assessed based on changes in folate status. Healthy adults aged 18-65 years (n 163) completed a 16-week placebo-controlled intervention study in which the relative bioavailability of increased folate intake (453 nmol/d) from folate-rich foods was assessed by comparing changes in plasma and erythrocyte folate concentration with changes induced by an equal reference dose of supplemental (6S)-5-methyltetrahydrofolic acid or folic acid. The relative increase in plasma folate concentration in the food group was 31 % when compared with that induced by folic acid, but 39 % when compared with (6S)-5-methyltetrahydrofolic acid. The relative increase in erythrocyte folate concentration in the food group when compared with that induced by folic acid was 43 %, and 40 % when compared with (6S)-5-methyltetrahydrofolic acid. When recent published observations were additionally taken into account it was concluded that, in principle, folic acid should not be used as the reference folate when attempting to estimate relative natural (food) folate bioavailability in longer-term human intervention studies. Using (6S)-5-methyltetrahydrofolic acid as the reference folate would avoid future results' validity being questioned.

  14. Criminal convictions among dependent heroin users during a 3-year period prior to opioid maintenance treatment: a longitudinal national cohort study.

    PubMed

    Bukten, Anne; Skurtveit, Svetlana; Stangeland, Per; Gossop, Michael; Willersrud, Astrid B; Waal, Helge; Havnes, Ingrid; Clausen, Thomas

    2011-12-01

    This study investigates frequency and types of criminal convictions among a national sample of heroin users during a 3-year period prior to opioid maintenance treatment (OMT). All heroin users (N = 3,789) in Norway who applied for and were eligible for OMT (1997-2003) were included. The OMT records were cross-linked to Norwegian crime statistics. During observation, 24,478 convictions were recorded among 60.9% of the sample. Differences of criminal convictions were found within the group; a large proportion (39.1%) had no convictions, whereas 10% of the sample was responsible for 37.8% of all convictions. Convictions for acquisitive crimes and drug crimes were the most common. Variations in the cohort's individual crime sequences were found. The heavy involvement of heroin users with the criminal justice system provides an opportunity to intervene with dependent offenders. Coordination between treatment providers and police or courts can play an important role in improving outcomes through better access to treatment.

  15. ASME N511-19XX, Standard for periodic in-service testing of nuclear air treatment, heating, ventilating and air conditioning systems

    SciTech Connect

    1997-08-01

    A draft version of the Standard is presented in this document. The Standard covers the requirements for periodic in-service testing of nuclear safety-related air treatment, heating, ventilating, and air conditioning systems in nuclear facilities. The Standard provides a basis for the development of test programs and does not include acceptance criteria, except in cases where the results of one test influence the performance of other tests. The Standard covers general inspection and test requirements, reference values, inspection and test requirements, generic tests, acceptance criteria, in-service test requirements, testing following an abnormal incident, corrective action requirements, and quality assurance. Mandatory appendices provide a visual inspection checklist and four test procedures. Non-mandatory appendices provide additional information and guidance on mounting frame pressure leak test procedure, corrective action, challenge gas substitute selection criteria, and test program development. 8 refs., 10 tabs.

  16. Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections.

    PubMed

    Balkus, Jennifer E; Richardson, Barbra A; Mandaliya, Kishorchandra; Kiarie, James; Jaoko, Walter; Ndinya-Achola, Jeckoniah O; Marrazzo, Jeanne; Farquhar, Carey; McClelland, R Scott

    2011-07-15

    Data from a randomized trial of oral periodic presumptive treatment (PPT) to reduce vaginal infections were analyzed to assess the effect of the intervention on a healthy vaginal environment (normal flora confirmed by Gram stain with no candidiasis or trichomoniasis). The incidence of a healthy vaginal environment was 608 cases per 100 person-years in the intervention arm and 454 cases per 100 person-years in the placebo arm (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.17-1.58). Sustained vaginal health (healthy vaginal environment for ≥3 consecutive visits) was also more frequent in the intervention arm (HR, 1.69; 95% CI, 1.23-2.33). PPT is effective at establishing and sustaining a healthy vaginal environment.

  17. Comparison between Long- and Short-Acting Erythropoiesis-Stimulating Agents in the Period Required for Haemoglobin Stabilisation in Treatment of Anaemia in Patients with Chronic Kidney Disease.

    PubMed

    Hayashi, Takahiro; Nagamatsu, Tadashi; Matsushita, Ayako; Mizuno, Tomohiro; Nishibe, Seira; Noguchi, Ayaka; Kato, Rina; Toda, Takahiro; Tanaka, Junko; Takahashi, Hiroshi; Hayashi, Hiroki; Yuzawa, Yukio; Yamada, Shigeki

    2015-01-01

    Comparative studies of the potency of long- and short-acting erythropoiesis-stimulating agents (L-ESAs and S-ESAs) on erythropoietic activity in patients with chronic kidney disease without dialysis have not been performed, although L-ESAs are used in many countries. We performed a retrospective analysis of non-dialysis (ND) patients who had received L-ESA or S-ESA. More days were needed for the S-ESA-treated group (368 d) to reach the haemoglobin (Hb) reference range than for the L-ESA-treated group (126 d). Therefore, we investigated risk factors that influence the period until the Hb level reaches the reference range. Patients were classified into two groups by the period until the Hb level was stabilised within the reference range: the short- and long-term group. Two risk factors for delayed Hb stabilisation were identified: age ≥60 years; and administration of an S-ESA for initial treatment. These findings suggest that the Hb level should be carefully monitored during ESA therapy in elderly ND patients, and that the ESA dose should be increased or L-ESA therapy should be utilised to treat renal anaemia.

  18. Antimicrobial resistance in commensal Escherichia coli from pigs during metaphylactic trimethoprim and sulfamethoxazole treatment and in the post-exposure period.

    PubMed

    Mazurek, Justyna; Bok, Ewa; Stosik, Michał; Baldy-Chudzik, Katarzyna

    2015-02-01

    The prevalence of trimethoprim (TMP) and sulfamethoxazole (SMX) resistance in commensal E. coli from pigs was tested in this study. E. coli was derived from three groups of piglets in successive stages of metaphylactic therapy and from two groups of sows 10 and 18 weeks after the treatment. MIC values of TMP and SMX were determined for a total of 352 strains. The presence of resistance genes (dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, sul1, sul2, sul3) and class 1 and 2 integron-associated dfrA gene cassettes was tested. Resistance to TMP was very high during the administration of the antimicrobial (from 97 to 100%) and amounted to 86% and 69% in the post-exposure period; MIC > 32 mg/L. The isolates from all groups of pigs were resistant to sulfamethoxazole, with MIC > 1028 mg/L. The dfrA1 and sul1 genes (as part of integrons) dominated in E. coli from piglets, but the dfrA12 and sul1 genes were prevalent in E. coli from sows. Coexistence of the different dfrA genes was detected in 71 isolates from all groups of swine. Transcription analysis revealed that most of these genes were not transcribed, particularly gene cassettes of class 1 integrons. The research revealed a high level of resistance associated with the metaphylactic treatment, persistence and circulation of resistance in bacterial populations. Diverse genetic background with multiple and not transcribed resistance genes was observed. PMID:25689993

  19. A multicenter, open-label extension study of velaglucerase alfa in Japanese patients with Gaucher disease: Results after a cumulative treatment period of 24months.

    PubMed

    Ida, Hiroyuki; Tanaka, Akemi; Matsubayashi, Tomoko; Murayama, Kei; Hongo, Teruaki; Lee, Hak-Myung; Mellgard, Björn

    2016-07-01

    Enzyme replacement therapy (ERT) with exogenous glucocerebrosidase is indicated to treat symptomatic Gaucher disease (GD), a rare, inherited metabolic disorder. ERT with velaglucerase alfa, which is produced in a human cell line using gene activation technology, was studied in a 12-month phase III trial in Japanese patients with type 1 or 3 GD who were switched from imiglucerase ERT (n=6); the current, open-label, 12-month extension study was designed to assess longer-term safety and efficacy. Two adult and three pediatric patients (aged <18years) were enrolled into the extension study. Every-other-week intravenous infusions were administered for 63-78weeks at average doses between 51.5 and 60.7units/kg. Three non-serious adverse events were considered related to velaglucerase alfa treatment, but no patient discontinued from the study. Six serious but non-drug-related adverse events were reported. No patient tested positive for anti-velaglucerase alfa antibodies. Hemoglobin concentrations, platelet counts, and liver and spleen volumes (normalized to body weight) in these patients were generally stable over a cumulative 24-month period from the baseline of the parent trial. The data suggest that velaglucerase alfa was well tolerated and maintained clinical stability in Japanese GD patients over 2years after switching from imiglucerase. ClinicalTrials.gov identifier NCT01842841. PMID:27241455

  20. Treatment of fatty solid waste from the meat industry in an anaerobic sequencing batch reactor: start-up period and establishment of the design criteria.

    PubMed

    Martinez-Sosa, D; Torrijos, M; Buitron, G; Sousbie, P; Devillers, P H; Delgenès, J P

    2009-01-01

    An anaerobic sequencing batch reactor (AnSBR) was used to treat the dissolved air flotation skimmings from a cooked pork meat plant. During the start-up period, the reactor was operated in fed-batch mode for 25 days and 7 batches were treated. The SBR was inoculated with sludge taken from a reactor treating distillery vinasse. The results showed that this kind of sludge is a very good source of inoculum for digesters treating residues with a high content in fats and long-chain fatty acids because it was able to adapt very rapidly to the new substrate and, from the second batch on, the sludge was already able to metabolize the fatty residue at quite high rates. The AnSBR was then operated with 5 batches per week for 110 days and the quantity of VS added per batch was regularly increased until the maximum treatment capacity of the reactor (i.e. maximum loading rate) was reached. The maximum organic loading rates were found to be 0.16 g VS/g VSS d, or 0.224 g VS/g VSS.batch when the reactor is fed 5 times a week. The biodegradability of the skimmings was very high, with more than 97% of TS removal, and the methane production was 880+/-90 mL of methane/g of VS(added).

  1. Randomized, observer-blind, split-face study to compare the irritation potential of 2 topical acne formulations over a 14-day treatment period.

    PubMed

    Ting, William

    2012-08-01

    This randomized, observer-blind, split-face study assessed the irritation potential and likelihood of continued use of clindamycin phosphate 1.2%--benzoyl peroxide (BPO) 2.5% gel or adapalene 0.1%--BPO 2.5% gel once daily over a 14-day treatment period in 21 participants (11 males; 10 females) with acne who were 18 years or older. Investigator clinical assessment (erythema and dryness) and self-assessment (dryness and burning/stinging) were performed at baseline and each study visit (days 1-14) using a 4-point scale (O = none; 3 = severe). Transepidermal water loss (TEWL) and corneometry measurements were performed at baseline and days 3, 5, 7, 9, 11, and 14. Lesions were counted at baseline and on day 14. Participant satisfaction questionnaires were completed on days 7 and 14. At the end of the study, investigators reported none or only mild erythema in 86% (18/21) of participants treated with clindamycin phosphate 1.2%--BPO 2.5% gel compared with 62% (13/21) of participants treated with adapalene 0.1%--BPO 2.5% gel. No severe erythema was reported with clindamycin phosphate 1.2%--BPO 2.5% gel. Adapalene 0.1%--BPO 2.5% gel was prematurely discontinued due to severe erythema in 1 participant on day 5 and a second participant on day 9. Additionally, 2 more participants reported severe erythema on day 14. Mean erythema scores were 0.9 (mean change from baseline, 0.7) with clindamycin phosphate 1.2%--BPO 2.5% gel and 1.4 (mean change from baseline, 1.3) with adapalene 0. 1%--BPO 2.5% gel on day 14 (P < .05 for days 6-14). Similar results were seen with dryness. Mean scores were 0.5 (mean change from baseline, 0.4) and 1.0 (mean change from baseline, 1.0), respectively (P < .05 for days 6-14). Self-assessment, TEWL, and corneometry results underscored the investigator clinical assessment. Participant preference and likelihood of continued usage was greater with clindamycin phosphate 1.2%--BPO 2.5% gel. Continued use and efficacy results for the treatment of acne were

  2. Randomized Controlled Trial for Behavioral Smoking and Weight Control Treatment: Effect of Concurrent Versus Sequential Intervention.

    ERIC Educational Resources Information Center

    Spring, Bonnie; Pagoto, Sherry; Pingitore, Regina; Doran, Neal; Schneider, Kristin; Hedeker, Don

    2004-01-01

    The authors compared simultaneous versus sequential approaches to multiple health behavior change in diet, exercise, and cigarette smoking. Female regular smokers (N = 315) randomized to 3 conditions received 16 weeks of behavioral smoking treatment, quit smoking at Week 5, and were followed for 9 months after quit date. Weight management was…

  3. Exploring the Relevance of Interpersonal Dependency as a Treatment Issue in Batterer Intervention

    ERIC Educational Resources Information Center

    Carney, Michelle Mohr; Buttell, Fred

    2006-01-01

    Objective: The purpose of the study was to (a) investigate the pretreatment levels of interpersonal dependency and violence among men entering a 16-week, court-mandated, batterer intervention program (BIP) and determine if there were any associations between interpersonal dependency and violence and (b) evaluate the treatment effect of a standard…

  4. Brief Daily Periods of Unrestricted Vision Preserve Stereopsis in Strabismus

    PubMed Central

    Smith, Earl L.; Hung, Li-Fang; Harwerth, Ronald S.

    2011-01-01

    Purpose. This study examines whether brief periods of binocular vision could preserve stereopsis in monkeys reared with optical strabismus. Methods. Starting at 4 weeks of age, six infant monkeys were reared with a total of 30 prism diopters base-in split between the eyes. Two of the six monkeys wore prisms continuously, one for 4 weeks and one for 6 weeks. Four of the six monkeys wore prisms but had 2 hours of binocular vision daily, one for 4, one for 6, and two for 16 weeks. Five normally reared monkeys provided control data. Behavioral methods were used to measure spatial contrast sensitivity, eye alignment, and stereopsis with Gabor and random dot targets. Results. The same pattern of results was evident for both local and global stereopsis. For monkeys treated for 4 weeks, daily periods of binocular vision rescued stereopsis from the 10-fold reduction observed with continuous optical strabismus. Six weeks of continuous strabismus resulted in stereo blindness, whereas daily periods of binocular vision limited the reduction to a twofold loss from normal. Daily periods of binocular vision preserved stereopsis over 16 weeks of optical strabismus for one of the two monkeys. Conclusions. Two hours of daily binocular vision largely preserves local and global stereopsis in monkeys reared with optical strabismus. During early development, the effects of normal vision are weighed more heavily than those of abnormal vision. The manner in which the effects of visual experience are integrated over time reduces the likelihood that brief episodes of abnormal vision will cause abnormal binocular vision development. PMID:21398285

  5. Surgical treatment of 137 cases with chronic subdural hematoma at the university clinical center of Kosovo during the period 2008–2012

    PubMed Central

    Mekaj, Agon Y.; Morina, Arsim A.; Mekaj, Ymer H.; Manxhuka-Kerliu, Suzana; Miftari, Ermira I.; Duci, Shkelzen B.; Hamza, Astrit R.; Gashi, Musli M.; Xhelaj, Mentor R.; Kelmendi, Fatos M.; Morina, Qamile Sh.

    2015-01-01

    Background: Chronic subdural hematoma (CSDH) is frequent pathology in neurosurgical practice. The aim of this study is to present the first series of patients with CSDH, who got surgically treated in Clinic of Neurosurgery, University Clinical Center of Kosovo. Materials and Methods: This is a retrospective study that included 137 patients with CSDH who had been treated during the period 2008–2012. The data were collected and analyzed from the archives and protocols of the University Clinical Center of Kosovo. Patients were analyzed in many aspects such as age, gender, etiological factors, clinical features, localization, diagnoses, methods of surgical interventions, recurrences and mortality of patients. Results: From 137 patients with CSDH, 106 (77.3%) were males and 31 (22.7%) females. Average age of patients was 62.85 years. Analyzed according to the decades, the highest number of causes with CSDH was between 70 and 79 years (46%). The head trauma has been responsible for CSDH in 88 patients (64.3%), while the main symptom was headache (92 patients or 67.1%). One burr-hole trepanation with closed drainage system has been used in majority of cases (in 101 patients or 73.7%). The recurrence of CSDH was 6.5%, whereas mortality 2.9%. Conclusion: CSDH is more common in elderly patients. The male-female ratio is 3.4:1. Like other authors we also think that treatment with one burr-hole and drainage is a method of choice, because of its simplicity and safety. PMID:25883478

  6. Buprenorphine pharmacotherapy and behavioral treatment: comparison of outcomes among prescription opioid users, heroin users and combination users.

    PubMed

    Nielsen, Suzanne; Hillhouse, Maureen; Mooney, Larissa; Ang, Alfonso; Ling, Walter

    2015-01-01

    Most research examining buprenorphine has been conducted with heroin users. Few studies have examined buprenorphine pharmacotherapy for prescription opioid users. Data were from a randomized controlled trial of behavioral treatment provided for 16weeks on a platform of buprenorphine pharmacotherapy and medication management. We compared heroin (H, n=54), prescription opioid (PO, n=54) and combination heroin+prescription opioid (POH, n=71) users to test the hypothesis that PO users will have better treatment outcomes compared with heroin users. The PO group provided more opioid-negative urine drug screens over the combined treatment period (PO:70%, POH:40%, H:38%, p<0.001) and at the end of the combined treatment period (PO:65%, POH:31%, H:33%, p<0.001). Retention was lowest in the H group (PO:80%, POH:65%, H:57%, p=0.039). There was no significant difference in buprenorphine dose between the groups. PO users appear to have better outcomes in buprenorphine pharmacotherapy compared to those reporting any heroin use, confirming that buprenorphine pharmacotherapy is effective in PO users. PMID:25065489

  7. Periodic Polymers

    NASA Astrophysics Data System (ADS)

    Thomas, Edwin

    2013-03-01

    Periodic polymers can be made by self assembly, directed self assembly and by photolithography. Such materials provide a versatile platform for 1, 2 and 3D periodic nano-micro scale composites with either dielectric or impedance contrast or both, and these can serve for example, as photonic and or phononic crystals for electromagnetic and elastic waves as well as mechanical frames/trusses. Compared to electromagnetic waves, elastic waves are both less complex (longitudinal modes in fluids) and more complex (longitudinal, transverse in-plane and transverse out-of-plane modes in solids). Engineering of the dispersion relation between wave frequency w and wave vector, k enables the opening of band gaps in the density of modes and detailed shaping of w(k). Band gaps can be opened by Bragg scattering, anti-crossing of bands and discrete shape resonances. Current interest is in our group focuses using design - modeling, fabrication and measurement of polymer-based periodic materials for applications as tunable optics and control of phonon flow. Several examples will be described including the design of structures for multispectral band gaps for elastic waves to alter the phonon density of states, the creation of block polymer and bicontinuous metal-carbon nanoframes for structures that are robust against ballistic projectiles and quasi-crystalline solid/fluid structures that can steer shock waves.

  8. Period Cramps

    MedlinePlus

    ... Check with a doctor to find out about pain relievers and other treatments that can reduce cramps. If you get them, don't let cramps sneak up on you! It's best to start taking pain relievers slightly in advance of the cramps. Your mom ...

  9. Treatment of canine pyoderma with ibafloxacin and marbofloxacin--fluoroquinolones with different pharmacokinetic profiles.

    PubMed

    Horspool, L J I; van Laar, P; van den Bos, R; Mawhinney, I

    2004-06-01

    Dogs with superficial or deep pyoderma (n = 228) presented to first opinion veterinarians (n = 20) were treated orally with either ibafloxacin, at a dosage of 15 mg/kg, or marbofloxacin, at a dosage of 2 mg/kg, once daily for 3-16 weeks. On initial presentation, 35% of the cases were classified as having recurrent pyoderma and 40% as having deep pyoderma. Staphylococci (mainly Staphylococcus intermedius) were isolated from over 90% of the cases. The average treatment periods were 41 +/- 26 and 38 +/- 21 days in the ibafloxacin and marbofloxacin groups, respectively. One week after the cessation of treatment, 74 and 81% of dogs (P > 0.05) in the ibafloxacin and marbofloxacin groups, respectively, were classified as having responded to treatment. One month after the cessation of treatment, 70% of the dogs in each group were still classified as cured or improved, and 3 and 11% (P < 0.05) in the ibafloxacin and marbofloxacin groups, respectively, were classified as having relapsed. Despite having different pharmacokinetic profiles, ibafloxacin and marbofloxacin produced similar results when used under field conditions at the recommended dosages.

  10. Treatment

    MedlinePlus

    ... Prevention Treatment 2003 U.S. Outbreak African Rodent Importation Ban For Clinicians Clinical Recognition Specimen Collection Treatment Smallpox ... Examining Animals with Suspected Monkeypox African Rodent Importation Ban Resources Related Links Poxvirus Molluscum Contagiosum Orf Virus ( ...

  11. Citalopram and imipramine in the treatment of depressive patients in general practice. A Nordic multicentre clinical study.

    PubMed

    Rosenberg, C; Damsbo, N; Fuglum, E; Jacobsen, L V; Horsgård, S

    1994-03-01

    Two dose levels of citalopram, 10-30 mg and 20-60 mg, were compared with imipramine, 50-150 mg, in depressed patients treated in general practice. This was a multicentre study carried out in Denmark, Sweden, Norway, and Finland. The duration of treatment was 6 weeks with an optional continuation phase of a further 16 weeks. The patients were assessed by means of the Hamilton Rating Scale for Depression (HAMD), Clinical Global Impressions (CGI), and a visual analogue self-rating scale for depression. Observed and spontaneously reported adverse events were recorded. A total of 472 patients were entered into the study and 400 patients completed the 6 week trial period. A total of 297 patients completed the optional 22 week double-blind period. A clear reduction of the HAMD total scores was seen in all three treatment groups with no significant differences between groups. A reduction of the HAMD anxiety factor and sleep factor scores was also seen with no significant differences between treatments. The imipramine-treated patients showed a higher frequency of adverse events, especially the anticholinergic type, than citalopram-treated patients. Most patients entered into the continuation phase remained well. PMID:8021437

  12. Treatment of delocalized electron transfer in periodic and embedded cluster DFT calculations: The case of Cu on ZnO (10(1)0).

    PubMed

    Hellström, Matti; Spångberg, Daniel; Hermansson, Kersti

    2015-12-15

    We assess the consequences of the interface model-embedded-cluster or periodic-slab model-on the ability of DFT calculations to describe charge transfer (CT) in a particularly challenging case where periodic-slab calculations indicate a delocalized charge-transfer state. Our example is Cu atom adsorption on ZnO(10(1)0), and in fact the periodic slab calculations indicate three types of CT depending on the adsorption site: full CT, partial CT, and no CT. Interestingly, when full CT occurs in the periodic calculations, the calculated Cu atom adsorption energy depends on the underlying ZnO substrate supercell size, since when the electron enters the ZnO it delocalizes over as many atoms as possible. In the embedded-cluster calculations, the electron transferred to the ZnO delocalizes over the entire cluster region, and as a result the calculated Cu atom adsorption energy does not agree with the value obtained using a large periodic supercell, but instead to the adsorption energy obtained for a periodic supercell of roughly the same size as the embedded cluster. Different density functionals (of GGA and hybrid types) and basis sets (local atom-centered and plane-waves) were assessed, and we show that embedded clusters can be used to model Cu adsorption on ZnO(10(1)0), as long as care is taken to account for the effects of CT. PMID:26525161

  13. Treatment

    MedlinePlus

    ... or check their website. Prescription Assistance Medicare Part D Prescription Drug Benefit Medicare pays for prescription medications ... you during the Annual Open Enrollment Period. Part D Low-Income Subsidy (LIS) If you have Medicare ...

  14. Early antipsychotic treatment in childhood/adolescent period has long-term effects on depressive-like, anxiety-like and locomotor behaviours in adult rats.

    PubMed

    De Santis, Michael; Lian, Jiamei; Huang, Xu-Feng; Deng, Chao

    2016-02-01

    Childhood/adolescent antipsychotic drug (APD) use is exponentially increasing worldwide, despite limited knowledge of the long-term effects of early APD treatment. Whilst investigations have found that early treatment has resulted in some alterations to dopamine and serotonin neurotransmission systems (essential to APD efficacy), there have only been limited studies into potential long-term behavioural changes. This study, using an animal model for childhood/adolescent APD treatment, investigated the long-term effects of aripiprazole, olanzapine and risperidone on adult behaviours of male and female rats. Open-field/holeboard, elevated plus maze (EPM), social interaction and forced swim (FS) tests were then conducted in adult rats. Our results indicated that in the male cohort, early risperidone and olanzapine treatment elicited long-term hyper-locomotor effects (open-field/holeboard and FS tests), whilst a decrease in depressive-like behaviour (in FS test) was observed in response to olanzapine treatment. Furthermore, anxiolytic-like behaviours were found following testing in the open-field/holeboard and EPM in response to all three drug treatments. Effects in the female cohort, however, were to a far lesser extent, with behavioural attributes indicative of an increased depressive-like behaviour and hypo-locomotor activity exhibited in the FS test following early risperidone and olanzapine treatment. These results suggest that various APDs have different long-term effects on the behaviours of adult rats.

  15. Thyrotoxic periodic paralysis

    SciTech Connect

    Ferreiro, J.E.; Arguelles, D.J.; Rams, H. Jr.

    1986-01-01

    A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself.

  16. Anaerobic treatment of tequila vinasses under seasonal operating conditions: start-up, normal operation and restart-up after a long stop and starvation period.

    PubMed

    Jáuregui-Jáuregui, J A; Méndez-Acosta, H O; González-Álvarez, V; Snell-Castro, R; Alcaraz-González, V; Godon, J J

    2014-09-01

    This study examines the performance of an anaerobic fixed-film bioreactor under seasonal operating conditions prevailing in medium and small size Tequila factories: start-up, normal operation and particularly, during the restart-up after a long stop and starvation period. The proposed start-up procedure attained a stable biofilm in a rather short period (28 days) despite unbalanced COD/N/P ratio and the use of non-acclimated inoculum. The bioreactor was restarted-up after being shut down for 6 months during which the inoculum starved. Even when biofilm detachment and bioreactor clogging were detected at the very beginning of restart-up, results show that the bioreactor performed better as higher COD removal and methane yield were attained. CE-SSCP and Q-PCR analyses, conducted on the biofilm prokaryotic communities for each operating condition, confirmed that the high COD removal results after the bioreactor clogging and the severe starvation period were mainly due to the stable archaeal and resilient bacterial populations.

  17. Early onset of changes to the reproductive system of Fasciola hepatica following in vivo treatment with triclabendazole.

    PubMed

    Hanna, R E B; Scarcella, S; Solana, H; McConnell, S; Fairweather, I

    2012-03-23

    Lambs infected with the Cullompton triclabendazole (TCBZ)-susceptible isolate of Fasciola hepatica were treated with TCBZ at a dosage of 10mg/kg at 16 weeks post-infection. Adult flukes were recovered from the liver at 3h, 24h, 48 h and 60 h post-treatment (pt). They were processed for histological analysis of the uterus, Mehlis' gland, vitellaria, ovary and testis. At 3h pt, the flukes were essentially similar to the controls and were producing normal eggs. Egg production had ceased by 24h pt. At this time period, the cells of the Mehlis' gland showed some evidence of vacuolation, but otherwise were relatively normal. A shift in the population of vitelline cells towards mature cells was observed at 24h pt, and this trend continued at later time-periods. It was accompanied by a breakdown of the cells and the presence of apoptotic bodies. Marked changes to the ovary were first noted at 48 h pt, as evidenced by vacuolation and the presence of apoptotic bodies. Some disruption to the testis was seen at 24h pt, with a reduction in the population of spermatogenic cells, the appearance of apoptotic bodies and some peripheral vacuolation of the tubules. These abnormalities increased in severity with longer time periods pt. The results bring forward the time-line of cessation of egg production by 24h, demonstrating that this process is affected very rapidly pt.

  18. Short-term alpha-tocopherol treatment during neonatal period modulates pro-inflammatory response to endotoxin (LPS) challenge in the same calves several months later

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Vitamin E, a major natural antioxidant, has been previously shown to attenuate pro-inflammatory response to immune challenge in cattle. Our objective was to evaluate the effect of short-term treatment with alpha-tocopherol in newborn calves on selected elements of the pro-inflamatory response to LPS...

  19. Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre.

    PubMed

    Karau, Paul B; Mutwiri, Mwikamba G; Ogeng'o, Julius A; Karau, Geoffrey M

    2013-03-01

    Treatment of cervical incompetence by cerclage and other methods has yet to be standardized, as its diagnosis is not uniformly accepted. Its diagnosis, particularly in the African setting, is mostly based on past obstetric history of pregnancy losses, while in developed centres; ultrasound diagnosis is increasingly being used. The mainstay of treatment in developing countries is cervical cerclage, although the indications and contraindications of this mode of treatment are not documented. Our aim was to appraise this practice in terms of patient characteristics, the diagnostic process and management at the Kenyatta National Hospital, Nairobi, Kenya. This was a descriptive retrospective study over 9 years. Predesigned questionnaires were employed to collect data on patient's socio-demographic profile, presentation, risk factors, diagnosis and management of cervical incompetence. Chi-squared test and student's t-test were used to correlate variables. A total of 199 patients were treated for cervical incompetence, with the patient mean age being 27.97. 87.4% of the patients (p = 0.02) were in the 20 to 35 years category. Most of the patients (60.1%) were of low socio-economic status. Cervical cerclage was employed in all the patients, although ultrasound investigation was not employed in 65.8% of them. Diagnosis of cervical incompetence still relies on history of previous pregnancy losses, with the standard transvaginal ultrasound relatively unemployed. There is need to intensify investigations for this condition, standardize the indications for cerclage, and diversify management to other newer modalities.

  20. Long-term efficacy of psoriasis vulgaris treatments: analysis of treatment with topical corticosteroid and/or vitamin D3 analog, oral cyclosporin, etretinate and phototherapy over a 35-year period, 1975-2010.

    PubMed

    Akasaka, Emiko; Mabuchi, Tomotaka; Manabe, Yasuaki; Yahagi, Eiichiro; Yamada-Hiruma, Azusa; Yamaoka, Hanako; Kojima, Tomoko; Kato, Masayuki; Ikoma, Norihiro; Ozawa, Akira; Haruki, Yasuo

    2013-04-01

    Various therapies have been tried for psoriasis. In Japan, biologics began to be used for psoriasis treatment in January 2010. Their clinical efficacy is well known, but biologics cannot be used in all psoriasis patients for reasons such as side-effects and cost. It is necessary to evaluate the effect of long-term psoriasis treatment, but there have been no reports evaluating long-term treatment. Therefore, the outcomes of patients who had been treated at the Tokai University Hospital for more than 5 years, before biological agents were released, were examined. Three categories, classified by initial severity, changes in severity by method of treatment and background characteristics, were investigated. In conclusion, cases of long-term treatment with a combination of topical corticosteroid and topical vitamin D3 analog or oral cyclosporin were found to be effective therapies. Patients with a history of diabetes mellitus or cardiovascular disease of psoriasis were likely to be treatment resistant.

  1. Changes in soil C-isotopic composition in an agroecosystem under Free Air Carbon dioxide Enrichment (FACE) treatment during a crop rotation period.

    PubMed

    Giesemann, Anette

    2005-01-01

    FACE (Free Air Carbon dioxide Enrichment) has been used since 1999 to evaluate the effects of future atmospheric CO(2) concentrations on an arable crop agroecosystem. The experiment conducted at the Institute of Agroecology at the Federal Research Centre in Braunschweig consists of a typical local crop rotation of winter barley, a cover crop, sugar beet and winter wheat. The atmospheric CO2 concentration of ambient air is about 375 ppm with a delta13C value of -7 to -9 per thousand, and 550 ppm (delta13C value = -20.2 per thousand) during daylight hours in the rings fumigated with additional CO2. Thus, the surplus C can be traced in the agricultural system. Over the course of the first experimental period (3-year crop rotation period), the C-isotopic composition and the C concentration in soil were monitored monthly. Plant samples were analysed according to the relevant developmental stages of the crop under cultivation. A 13C depletion was observed in plant parts, as well as in soil samples from the FACE rings under CO2 enrichment, indicating that labelled C has reached both respective ecosystem compartments. Albeit farming management practice (especially ploughing) leads to a mixing of 'old' and 'new' C compounds throughout all soil horizons down to the end of the ploughing layer and resulted in a heterogeneous distribution of newly formed C compounds in the soil, isotope analysis of soil C reflected where the surplus C went.

  2. Growth hormone treatment of adolescents with growth hormone deficiency (GHD) during the transition period: results of a survey among adult and paediatric endocrinologists from Italy. Endorsed by SIEDP/ISPED, AME, SIE, SIMA.

    PubMed

    Aimaretti, G; Attanasio, R; Cannavò, S; Nicoletti, M C; Castello, R; Di Somma, C; Garofalo, P; Iughetti, L; Loche, S; Maghnie, M; Mazzanti, L; Saggese, G; Salerno, M; Tonini, G; Toscano, V; Zucchini, S; Cappa, M

    2015-03-01

    Treatment of adolescents with growth hormone deficiency (GHD) during the transition period is a controversial issue. This paper is a contribution from the Italian community of paediatric and adult endocrinologists surveyed in a Delphi panel. The Delphi method is a structured communication technique, originally developed as a systematic, interactive forecasting method that relies on a panel of experts. The experts answer questionnaires in two or more rounds. There was substantial agreement on the definition of the problems associated with the diagnosis and treatment of adolescents with GHD in the transition period, as well as on the identification of the controversial issues which need further studies. There is general consensus on the need of re-testing all isolated idiopathic GHD after at least 30-day withdrawn from treatment, while in patients with multiple pituitary deficiency and low IGF-I levels there is generally no need to re-test. In patients with permanent or confirmed GHD, a starting low rhGH dose (0.01-0.03 mg per day) to be adjusted according to IGF-I concentrations is also widely accepted. For those continuing treatment, the optimal therapeutic schedule to obtain full somatic maturation, normalization of body composition and bone density, cardiovascular function and Quality of Life, need to be evaluated. PMID:25362629

  3. Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre.

    PubMed

    Silva, Rosiana Estéfane da; Toledo, Antonio; Senna, Maria Camilo; Rabello, Ana; Cota, Gláucia

    2016-08-01

    Although intralesional meglumine antimoniate (MA) infiltration is considered an option for cutaneous leishmaniasis (CL) therapy and is widely used in the Old World, there have been few studies supporting this therapeutic approach in the Americas. This study aims to describe outcomes and adverse events associated with intralesional therapy for CL. This retrospective study reviewed the experience of a Brazilian leishmaniasis reference centre using intralesional MA to treat 31 patients over five years (2008 and 2013). The median age was 63 years (22-86) and the median duration time of the lesions up to treatment was 16 weeks. In 22 patients (71%), intralesional therapy was indicated due to the presence of contraindications or previous serious adverse events with systemic MA. Other indications were failure of systemic therapy or ease of administration. Intralesional treatment consisted of one-six infiltrations (median three) for a period of up to 12 weeks. The initial (three months) and definitive (six months) cure rates were 70.9% and 67.7%, respectively. Most patients reported mild discomfort during infiltration and no serious adverse events were observed. In conclusion, these results show that the intralesional MA efficacy rate was very similar to that of systemic MA treatment, and reinforce the need for further studies with adequate design to establish the efficacy and safety of this therapeutic approach.

  4. Intralesional meglumine antimoniate for the treatment of localised cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre

    PubMed Central

    da Silva, Rosiana Estéfane; Toledo, Antonio; Senna, Maria Camilo; Rabello, Ana; Cota, Gláucia

    2016-01-01

    Although intralesional meglumine antimoniate (MA) infiltration is considered an option for cutaneous leishmaniasis (CL) therapy and is widely used in the Old World, there have been few studies supporting this therapeutic approach in the Americas. This study aims to describe outcomes and adverse events associated with intralesional therapy for CL. This retrospective study reviewed the experience of a Brazilian leishmaniasis reference centre using intralesional MA to treat 31 patients over five years (2008 and 2013). The median age was 63 years (22-86) and the median duration time of the lesions up to treatment was 16 weeks. In 22 patients (71%), intralesional therapy was indicated due to the presence of contraindications or previous serious adverse events with systemic MA. Other indications were failure of systemic therapy or ease of administration. Intralesional treatment consisted of one-six infiltrations (median three) for a period of up to 12 weeks. The initial (three months) and definitive (six months) cure rates were 70.9% and 67.7%, respectively. Most patients reported mild discomfort during infiltration and no serious adverse events were observed. In conclusion, these results show that the intralesional MA efficacy rate was very similar to that of systemic MA treatment, and reinforce the need for further studies with adequate design to establish the efficacy and safety of this therapeutic approach. PMID:27508321

  5. Impact of progesterone and estradiol treatment before the onset of the breeding period on reproductive performance of Bos indicus beef heifers.

    PubMed

    Sá Filho, M F; Nasser, L F T; Penteado, L; Prestes, R; Marques, M O; Freitas, B G; Monteiro, B M; Ferreira, R M; Gimenes, L U; Baruselli, P S

    2015-09-01

    The present aimed to develop a hormonal therapy based on the insertion of a progesterone (P4) insert (PI) during 10 d plus an estradiol injection (E2) at PI removal before the onset of breeding of beef heifers. In Exp. 1, the plasma P4 profile of prepubertal heifers showed that the insertion of a PI or 24 d previously used P4 insert (UPI) sustained plasma P4 above 1 ng/mL for at least the first 7 d of the treatment. In Exp. 2 there was no positive effect of additional estradiol benzoate (EB) administered at the insertion of UPI on the proportion of heifers with a corpus luteum (CL/Treated) 30 d after UPI removal [UPI + EB = 85.3%(a) (n = 134); EB + UPI + EB = 80.8%(a) (n = 125)]; however, both were greater (P < 0.0001) than the Control group [60.3%(b) (n = 129)]. In Exp. 3, a positive effect (P=0.01) of UPI treatment and both E2 supplementations [EB and estradiol cypionate (EC); P = 0.10] at the UPI removal was observed on CL/Treated [Control = 42.5%(b) (n = 94); UPI = 58.5%(a) (n= 130); UPI + EB = 64.0%(a) (n = 128); UPI + EC = 67.2%(a) (n = 128)]. However, greater pregnancy per treated heifer (P/Treated) following artificial insemination (AI) upon estrus detection was achieved when EC was applied [Control = 20.2%(b); UPI = 29.2%(ab); UPI + EB = 26.6%(b); UPI + EC = 36.7%(a)]. In Exp. 4, the treatment prior to the timed AI (TAI) tended to improve pregnancy per TAI [P/AI; Control 43.6% (n = 298) vs. UPI+EC 51.9% (n = 342); P = 0.08], but increased P/Treated [26.5% vs. 43.3%; P < 0.001]. Thus, UPI + EC treatment were efficient in increasing the CL/Treated, tended to improve the P/AI and consequently enhanced P/Treated of zebu beef heifers.

  6. Should home-based HIV testing and counseling services be offered periodically in programs of ARV treatment as prevention? A case study in Likoma (Malawi)

    PubMed Central

    Helleringer, Stéphane; Mkandawire, James; Reniers, Georges; Kalilani-Phiri, Linda; Kohler, Hans-Peter

    2012-01-01

    To reduce HIV incidence, prevention programs centered on the use of antiretrovirals require scaling-up HIV testing and counseling (HTC). Home-based HTC services (HBHTC) increase HTC coverage, but HBHTC has only been evaluated during one-off campaigns. Two years after an initial HBHTC campaign (“round 1”), we conducted another HBHTC campaign (“round 2”) in Likoma (Malawi). HBHTC participation increased during round 2 among women (from 74% to 83%, p<0.01). New HBHTC clients were recruited, especially at ages 25 and older. Only 6.9% of women but 15.9% of men remained unreached by HBHTC after round 2. HIV prevalence during round 2 was low among clients who were HIV-negative during round 1 (0.7%), but high among women who first tested during round 2 (42.8%). The costs per newly diagnosed infection increased significantly during round 2. Periodically conducting HBHTC campaigns can further increase HTC, but supplementary interventions to enroll individuals not reached by HBHTC are needed. PMID:23180155

  7. The classical electrostatic periodic table, capacitance of few electron dielectric spheres and a novel treatment of one- and two-electron finite quantum wells

    NASA Astrophysics Data System (ADS)

    Lafave, Tim, Jr.

    The centerpiece of this dissertation is the discovery of the classical electrostatic periodic table of elements through non-linear ground state energies coincident with atomic shell-filling resulting from symmetry properties of discrete electrons constrained by a spherically-symmetric system. The time-independent electrostatic equilibrium configuration of few electrons confined to a large classical dielectric sphere is obtained by minimization of the total interaction energy. The interactions model yields more than twice the energy predicted by the classical Gauss model. Each N-electron system is proposed as a unique phase characterized by its symmetry properties. A new mono-phasic capacitance definition of dielectric spheres is derived from the fundamental relation Q=CV. Large differences from the Gauss model are obtained for few-electron systems, but convergence is found in the metallic limit. Of particular significance is the means by which symmetry-dependent properties of atomic-scale devices may be exploited by controlling the internal architecture of charge distributions. This work will be useful to modeling of many-electron chemical and biological systems, such as macromolecules, owing largely to symmetry differences between the Gauss model and the interactions model. The foundation upon which all Nature rests is the symmetry of fundamental particles.

  8. Randomized Trial of Periodic Presumptive Treatment With High-Dose Intravaginal Metronidazole and Miconazole to Prevent Vaginal Infections in HIV-negative Women

    PubMed Central

    McClelland, R. Scott; Balkus, Jennifer E.; Lee, Jeannette; Anzala, Omu; Kimani, Joshua; Schwebke, Jane; Bragg, Vivian; Lensing, Shelly; Kavak, Lale

    2015-01-01

    Background. Vaginal infections are common, frequently recur, and may increase women's risk for sexually transmitted infections (STIs). We tested the efficacy of a novel regimen to prevent recurrent vaginal infections. Methods. Human immunodeficiency virus (HIV)–negative women 18–45 years old with 1 or more vaginal infections, including bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), or Trichomonas vaginalis (TV), were randomly assigned to receive vaginal suppositories containing metronidazole 750 mg plus miconazole 200 mg or matching placebo for 5 consecutive nights each month for 12 months. Primary endpoints, evaluated every 2 months, were BV (Gram stain) and VVC (positive wet mount and culture). Results. Participants (N = 234) were randomly assigned to the intervention (N = 118) or placebo (N = 116) arm. Two hundred seventeen (93%) women completed an end-of-study evaluation. The intervention reduced the proportion of visits with BV compared to placebo (21.2% vs 32.5%; relative risk [RR] 0.65, 95% confidence interval [CI] .48–.87). In contrast, the proportion of visits with VVC was similar in the intervention (10.4%) versus placebo (11.3%) arms (RR 0.92, 95% CI .62–1.37). Conclusions. Monthly treatment with intravaginal metronidazole plus miconazole reduced the proportion of visits with BV during 12 months of follow-up. Further study will be important to determine whether this intervention can reduce women's risk of STIs. PMID:25526757

  9. Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren.

    PubMed

    Smith, A W; Hatcher, J; Mackenzie, I J; Thompson, S; Bal, I; Macharia, I; Mugwe, P; Okoth-Olende, C; Oburra, H; Wanjohi, Z

    1996-10-26

    524 children aged 5-15 years with chronic suppurative otitis media (CSOM) were enrolled in a study to determine the effectiveness of different treatment regimens. The subjects were from 145 primary schools in Kenya's Kiambu district. 201 children received dry mopping treatment, 221 received dry mopping with topical and systemic antibiotics and topical steroids, and 102 received no treatment. Participating schools were matched on factors thought to be related to their socioeconomic status. 29 children were withdrawn from the trial for taking non-trial antibiotics, with no evidence observed of differences in the timing of withdrawals between the two groups. At 16 weeks of follow-up, otorrhoea had resolved in a weighted mean proportion of 51% of children who received dry mopping with antibiotics, 22% of children who received dry mopping alone, and 22% of untreated children. Similar differences were observed at 8 and 12 weeks of follow-up. The weighted mean proportions of children with healing of the tympanic membranes by 16 weeks were 15% in the dry-mopping plus antibiotics group, 13% in the dry-mopping alone group, and 13% in the control group. Hearing thresholds were significantly better for children with no otorrhoea at 16 weeks than for those who had otorrhoea, and were also significantly better for those whose ears had healed than for those with otorrhoea at all times.

  10. Implementation of Cognitive-Behavioral Substance Abuse Treatment in Sub-Saharan Africa: Treatment Engagement and Abstinence at Treatment Exit

    PubMed Central

    Burnhams, Warren; Remmert, Jocelyn E.; Myers, Bronwyn; Joska, John A.; Carrico, Adam W.

    2016-01-01

    Aims This study documented the treatment cascade for engagement in care and abstinence at treatment exit as well as examined correlates of these outcomes for the first certified Matrix Model® substance abuse treatment site in Sub-Saharan Africa. Design This retrospective chart review conducted at a resource-limited community clinic in Cape Town, South Africa, assessed treatment readiness and substance use severity at treatment entry as correlates of the number of sessions attended and biologically confirmed abstinence at treatment exit among 986 clients who initiated treatment from 2009–2014. Sociodemographic and clinical correlates of treatment outcomes were examined using logistic regression, modeling treatment completion and abstinence at treatment exit separately. Results Of the 2,233 clients who completed screening, approximately 44% (n = 986) initiated treatment. Among those who initiated treatment, 45% completed at least four group sessions, 30% completed early recovery skills training (i.e., at least eight group sessions), and 13% completed the full 16-week program. Approximately half (54%) of clients who provided a urine sample had negative urine toxicology results for any substance at treatment exit. Higher motivation at treatment entry was independently associated with greater odds of treatment completion and negative urine toxicology results at treatment exit. Conclusions Findings provide initial support for the successful implementation the Matrix Model in a resource-limited setting. Motivational enhancement interventions could support treatment initiation, promote sustained engagement in treatment, and achieve better treatment outcomes. PMID:26816208

  11. Infections with gastrointestinal parasitic helminths indigenous to Japan and their treatment historically studied in an attempt to control the diseases in countries where they are still rampant: (1) the Jomon to Edo periods.

    PubMed

    Maki, Jun; Sakagami, Hiroshi; Kuwada, Masahiro; Caceres, Armando; Sekiya, Hiroshi; Tamai, Eiji

    2009-01-01

    Infections with gastrointestinal parasitic helminthes were historically surveyed from the Jomon period to the end of the Edo period in Japan. The parasitic helminthes whose eggs or symptoms were shown in the remains and bibliographies are the roundworm, whipworm, liver fluke, Yokogawa's fluke and the cestode, Diphyllobothrium sp. The first two are soil-transmitted nematodes and the other three parasitic helminths are those with which people are infected following eating raw fish. The infection routes provide valuable information on the environments, life-style and customs in those days. The eggs of the soil-transmitted parasites have the thick shells resistant to the environments. Humans are infected with the parasites after the eggs are orally ingested with soil, dust, vegetables grown with night soil or manure. When the custom of the night soil was started in the history of Japan was discussed with this infection route. In ancient times, feces are thought to have been discarded. In the Medieval Period, they were started to be used as a fertilizer. No mature types of manure were used until the modern times (already in the Edo period). To our idea, no recoveries of eggs of hookworms causing severe anemia do not necessarily mean that people were not infected with the parasites in those days because the eggs are covered with thin shells liable to rupture. The latter fact of the eggs of the platihelminths, C. sinensis, M. yokogawai and D. latum has something to do with Japanese traditional eating customs, unequivocally demonstrating that they ate raw fish from the Nara Period, at latest, until today. Whether eggs of the cestode (D. latum) are found in Jomon remains, Momijiyama Iseki, Hokkaido should be investigated. If no eggs of the cestode are found in their toilet site or elsewhere, it could be concluded that they did not have the custom of eating raw salmon. Such a conclusion would be itself a new fact. One of the effective treatments for the cestode (D. latum

  12. Preparation of former heavyweight oarsmen to compete as lightweight rowers over 16 weeks: three case studies.

    PubMed

    Slater, Gary J; Rice, Anthony J; Jenkins, David; Gulbin, Jason; Hahn, Allan G

    2006-02-01

    To strengthen the depth of lightweight rowing talent, we sought to identify experienced heavyweight rowers who possessed physique traits that predisposed them to excellence as a lightweight. Identified athletes (n = 3) were monitored over 16 wk. Variables measured included performance, anthropometric indices, and selected biochemical and metabolic parameters. All athletes decreased their body mass (range 2.0 to 8.0 kg), with muscle mass accounting for a large proportion of this (31.7 to 84.6%). Two athletes were able to maintain their performance despite reductions in body mass. However, performance was compromised for the athlete who experienced the greatest weight loss. In summary, smaller heavyweight rowers can successfully make the transition into the lightweight category, being nationally competitive in their first season as a lightweight. PMID:16676707

  13. Dynamics of nitrifying bacterial communities in the Seine river and estuary as affected by changes in the treatment of Paris wastewater : a comparison of 2001-2003 vs 2012-2013 periods

    NASA Astrophysics Data System (ADS)

    Aissa Grouz, Najla; Billen, Gilles; Garnier, Josette; Mercier, Benjamin; Martinez, Anun

    2014-05-01

    The major branch of the Seine river from the confluence with the Marne river to the entrance of the estuary is deeply affected by the release of wastewater from the huge Paris agglomeration. In the first years of 2000, the largest part of the effluents were still discharged at the Seine-Aval (Achères) treatment plant with only a standard, low residence time, activated sludge treatment, thus releasing a high ammonium load. NH4 concentration as high as 7 mgN/l were frequently observed downstream from Paris agglomeration. Cébron et al. (2003, 2005) and Garnier et al. 2007 described in details how this massive reduced nitrogen concentrations triggered the growth of nitrifying bacteria, already present in the upstream Seine and Marne rivers, but also brought in large amount by the effluents of the wastewater treatment plant themselves. The decrease of ammonium concentration was slow, however, and was only completed 200 km downstream, in the upper estuarine area, where it causes a severe oxygen deficiency. Since 2007, important changes occurred in the treatment of nitrogen in the Parisian wastewater purification plants. In 2007, the Seine-Aval plant treated up to 90% of the ammonium contained in wastewater through nitrification, and 30% of the total supply of nitrates is treated by denitrification. These modifications have of course favorably affected the water quality of the Seine river: ammonium concentrations are reduced by a factor of 5 and the area of oxygen depletion in the upstream estuary is no more observed. However, nitrites, still released in the effluents, are a matter of concern for the water quality of the Seine downstream from Paris. Using measurements of potential microbial activities carried out with the same experimental protocol for the 2000-2003 and 2012-2013 periods, we here examine and model the dynamics of ammonium oxidizing and nitrite oxidizing microbial populations before and after the implementation of nitrification treatment of Paris

  14. Autism: a "critical period" disorder?

    PubMed

    LeBlanc, Jocelyn J; Fagiolini, Michela

    2011-01-01

    Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired communication, and repetitive behaviors or restricted interests. The underlying cause is still largely unknown and there is no fully effective treatment or cure. We propose that alteration of the expression and/or timing of critical period circuit refinement in primary sensory brain areas may significantly contribute to autistic phenotypes, including cognitive and behavioral impairments. Dissection of the cellular and molecular mechanisms governing well-established critical periods represents a powerful tool to identify new potential therapeutic targets to restore normal plasticity and function in affected neuronal circuits.

  15. Period meter for reactors

    DOEpatents

    Rusch, Gordon K.

    1976-01-06

    An improved log N amplifier type nuclear reactor period meter with reduced probability for noise-induced scrams is provided. With the reactor at low power levels a sampling circuit is provided to determine the reactor period by measuring the finite change in the amplitude of the log N amplifier output signal for a predetermined time period, while at high power levels, differentiation of the log N amplifier output signal provides an additional measure of the reactor period.

  16. Anxiety Impairs Depression Remission in Partial Responders During Extended Treatment in Late-Life

    PubMed Central

    Greenlee, Adam; Karp, Jordan F.; Dew, Mary Amanda; Houck, Patricia; Andreescu, Carmen; Reynolds, Charles F.

    2010-01-01

    Objectives More than half of older adults with major depressive disorder require extended treatment because of incomplete response during acute treatment. This study characterizes the effect of anxiety on remission during extended treatment for partial responders. Methods Following 6 weeks of escitalopram 10mg/day + Depression Care Management (DCM), 124 partial-responders (Hamilton Rating Scale for Depression (HRSD) scores of 11–14) were randomly assigned to receive extended treatment with escitalopram 20 mg/day + DCM with or without interpersonal psychotherapy (IPT) for 16 weekly sessions. Remission was defined as three consecutive weekly scores ≤7 on the HRSD. We assessed concurrent symptoms of anxiety using the Hamilton Rating Scale for Anxiety (HRSA) at pre-treatment and after 6 weeks. We conducted Cox regression analysis of time to remission and logistic modeling of rates of remission. We also explored whether anxiety severity altered any impact of IPT. Results Pre-treatment anxiety was not associated with time to or rates of remission during 16 weeks of extended treatment. In contrast, more severe psychological symptoms of anxiety after 6 weeks of treatment was associated with both longer time to and lower rates of remission. However, there was no evidence that IPT showed any differential effects as a function of anxiety. Conclusions In partial responders to six weeks of lower-dose escitalopram and DCM, planning for extended treatment should account for psychological symptoms of anxiety. PMID:20186975

  17. The Periodic Pyramid

    ERIC Educational Resources Information Center

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  18. A controlled trial of high dose interferon, alone and after prednisone withdrawal, in the treatment of chronic hepatitis B: long term follow up.

    PubMed Central

    Perez, V; Findor, J; Tanno, H; Sordá, J

    1993-01-01

    This study was designed to evaluate the safety and effectiveness of high dose interferon, with or without prednisone pretreatment, in patients with chronic hepatitis B. Patients were randomised to two treatment groups: group I (n = 26) received six weeks of prednisone followed by a two week, drug free period, and then 10 million units (MU) of interferon alfa-2b three times weekly subcutaneously for 16 weeks; group II (n = 24) were used as controls for 24 weeks and then treated with interferon. Loss of hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV)-DNA, with a return to normal alanine aminotransferase (ALT) activity, was seen in 16 of 26 group I patients (61.5%), in one group II patient (4.2%) during the control phase, and in 13 of 23 group II patients (56.5%) after interferon. Three of 26 (11.5%) in group I and one of 23 (4.3%) in group II eliminated the surface antigen (HBsAg). There were no statistically significant differences in response between groups I and II. Liver biopsies carried out in 20 patients showed that responders had a noticeable reduction in inflammation and disappearance of core antigen in liver tissue, changes not seen in non-responders. On long term follow up (four years), nine out of 28 responders (32.1%) eliminated HBsAg, and four initial non-responders had a late seroconversion. PMID:8314497

  19. Meditative Movement as a Treatment for Pulmonary Dysfunction in Flight Attendants Exposed to Second-Hand Cigarette Smoke: Study Protocol for a Randomized Trial.

    PubMed

    Payne, Peter; Zava, David; Fiering, Steven; Crane-Godreau, Mardi

    2016-01-01

    A study protocol is presented for the investigation of meditative movement (MM) as a treatment for pulmonary dysfunction in flight attendants (FA) who were exposed to second-hand cigarette smoke while flying before the smoking ban. The study will have three parts, some of which will run concurrently. The first is a data gathering and screening phase, which will gather data on pulmonary and other aspects of the health of FA, and will also serve to screen participants for the other phases. Second is an exercise selection phase, in which a variety of MM exercises will be taught, over a 16-week period, to a cohort of 20 FA. A subset of these exercises will be selected on the basis of participant feedback on effectiveness and compliance. Third is a 52-week randomized controlled trial to evaluate the effectiveness of a digitally delivered form of the previously selected exercises on a group of 20 FA, as compared with an attention control group. Outcome measures to be used in all three parts of the study include the 6-min walk test as a primary measure, as well as a range of biomarkers, tests, and questionnaires documenting hormonal, cardio-respiratory, autonomic, and affective state. This study is registered at ClinicalTrials.gov. Identifier: NCT02612389. PMID:27047398

  20. Meditative Movement as a Treatment for Pulmonary Dysfunction in Flight Attendants Exposed to Second-Hand Cigarette Smoke: Study Protocol for a Randomized Trial

    PubMed Central

    Payne, Peter; Zava, David; Fiering, Steven; Crane-Godreau, Mardi

    2016-01-01

    A study protocol is presented for the investigation of meditative movement (MM) as a treatment for pulmonary dysfunction in flight attendants (FA) who were exposed to second-hand cigarette smoke while flying before the smoking ban. The study will have three parts, some of which will run concurrently. The first is a data gathering and screening phase, which will gather data on pulmonary and other aspects of the health of FA, and will also serve to screen participants for the other phases. Second is an exercise selection phase, in which a variety of MM exercises will be taught, over a 16-week period, to a cohort of 20 FA. A subset of these exercises will be selected on the basis of participant feedback on effectiveness and compliance. Third is a 52-week randomized controlled trial to evaluate the effectiveness of a digitally delivered form of the previously selected exercises on a group of 20 FA, as compared with an attention control group. Outcome measures to be used in all three parts of the study include the 6-min walk test as a primary measure, as well as a range of biomarkers, tests, and questionnaires documenting hormonal, cardio-respiratory, autonomic, and affective state. This study is registered at ClinicalTrials.gov. Identifier: NCT02612389. PMID:27047398

  1. 40 CFR 264.96 - Compliance period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.96 Compliance period. (a) The Regional Administrator...

  2. 40 CFR 264.96 - Compliance period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.96 Compliance period. (a) The Regional Administrator...

  3. 40 CFR 264.96 - Compliance period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES Releases From Solid Waste Management Units § 264.96 Compliance period. (a) The Regional Administrator...

  4. Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity.

    PubMed

    Kreider, Marisa L; Tate, Charlotte A; Cousins, Mandy M; Oliver, Colleen A; Seidler, Frederic J; Slotkin, Theodore A

    2006-01-01

    Glucocorticoids administered to prevent respiratory distress in preterm infants are associated with neurodevelopmental disorders. To evaluate the long-term effects on forebrain development, we treated developing rats with dexamethasone (Dex) at 0.05, 0.2, or 0.8 mg/kg, doses below or spanning the range in clinical use, testing the effects of administration during three different stages: gestational days 17-19, postnatal days 1-3, or postnatal days 7-9. In adulthood, we assessed biomarkers of neural cell number and size, cholinergic presynaptic activity, neurotransmitter receptor expression, and synaptic signaling mediated through adenylyl cyclase (AC), in the cerebral cortex, hippocampus, and striatum. Even at doses that were devoid of lasting effects on somatic growth, Dex elicited deficits in the number and size of neural cells, with the largest effect in the cerebral cortex. Indices of cholinergic synaptic function (choline acetyltransferase, hemicholinium-3 binding) indicated substantial hyperactivity in males, especially in the hippocampus, effectively eliminating the normal sex differences for these parameters. However, the largest effects were seen for cerebrocortical cell signaling mediated by AC, where Dex treatment markedly elevated overall activity while obtunding the function of G-protein-coupled catecholaminergic or cholinergic receptors that stimulate or inhibit AC; uncoupling was noted despite receptor upregulation. Again, the effects on signaling were larger in males and offset the normal sex differences in AC. These results indicate that, during critical developmental periods, Dex administration evokes lasting alterations in neural cell numbers and synaptic function in forebrain regions, even at doses below those used in preterm infants.

  5. [Scientific periodicals: quality criteria].

    PubMed

    Ferreira, Maria Cecilia Gonzaga; Krzyzanowski, Rosaly Favero

    2003-05-01

    This paper presents a historical literature review on the evaluation of periodicals and the methodology employed for their evaluation. It emphasizes the attention that should be given to the contents of the periodicals and their format based on technical standards in order to reach a global quality of the publications. This paper includes a summary of the most important aspects of the technical standards for periodicals and scientific articles.

  6. 42 CFR 441.58 - Periodicity schedule.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Periodic Screening, Diagnosis, and Treatment (EPSDT) of Individuals Under Age 21 § 441.58 Periodicity... recognized medical and dental organizations involved in child health care; (b) Specifies screening services applicable at each stage of the recipient's life, beginning with a neonatal examination, up to the age...

  7. Saturn's variable radio period

    NASA Astrophysics Data System (ADS)

    Kurth, W. S.; Lecacheux, A.; Zarka, P.; Gurnett, D. A.; Cecconi, B.

    Temporal modulations in radio emissions are often used to determine the rotation rate of the emitting body. The rotation period (presumably) of Jupiter's interior was established in this way [Burke et al., 1962] and has recently been refined by Higgins et al. [1997]. Rotation periods for the remainder of the outer planet gas giants were determined from Voyager planetary radio astronomy observations. Similar techniques have been applied to astrophysical objects, including pulsars, for which the radio period is assumed to be the rotation period of the neutron star. In 2001, however, this simple relation between the radio period and rotation period became suspect, at least for the case of Saturn. Galopeau and Lecacheux [2001] reported that the radio period of Saturn had changed by as much as 1% from that determined by Voyager and, further, exhibited variations on time scales of years. More recently, Cassini observations indicate that the Saturn kilometric radiation is modulated with a period longer than that observed by Voyager and that this period is variable on a time scale of a year or less. The recent Higgins et al. result suggests that Jupiter's period is steady, within measurement accuracy. There are no additional measurements from Uranus or Neptune with which to look for time variations in their radio periods. For conservation of energy and angular momentum reasons, true variations of the rotation period of Saturn's deep interior are not believed to be a viable explanation for the variation in radio period, hence, it would appear that there is some disconnection of the radio period from the rotation period in the case of Saturn. One possible contributing factor may be that since Saturn's magnetic field is very accurately aligned with its rotational axis, there is no first-order beaming effect caused by the wobbling of the magnetic field, contrary to the situation at the other magnetized planets. Another explanation suggested by Galopeau and Lecacheux [2001] and

  8. Sequences close to periodic

    NASA Astrophysics Data System (ADS)

    Muchnik, Andrei A.; Pritykin, Yurii L.; Semenov, Aleksei L.

    2009-10-01

    This paper is a survey of concepts and results connected with generalizations of the notion of a periodic sequence, both classical and new. The topics discussed relate to almost periodicity in such areas as combinatorics on words, symbolic dynamics, expressibility in logical theories, computability, Kolmogorov complexity, and number theory. Bibliography: 124 titles.

  9. Multidimensional period doubling structures.

    PubMed

    Lee, Jeong Yup; Flom, Dvir; Ben-Abraham, Shelomo I

    2016-05-01

    This paper develops the formalism necessary to generalize the period doubling sequence to arbitrary dimension by straightforward extension of the substitution and recursion rules. It is shown that the period doubling structures of arbitrary dimension are pure point diffractive. The symmetries of the structures are pointed out. PMID:27126116

  10. The Living Periodic Table

    ERIC Educational Resources Information Center

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  11. Hyperkalemic periodic paralysis associated with multiple sleep onset REM periods.

    PubMed

    Iranzo, A; Santamaria, J

    1999-12-15

    A 24-year-old man with sporadic hyperkalemic periodic paralysis (HPP) presented with moderate excessive daytime sleepiness and transitory episodes of weakness which occurred during and after sleep. Multiple sleep latency test (MSLT) demonstrated the presence of five sleep onset REM periods (SOREMPs) and a sleep latency of five minutes. Treatment with a diuretic which decreases serum potassium resolved all the clinical symtomps and a new MSLT showed the absence of SOREMPs and a sleep latency of 13.5 minutes. To our knowledge, the patient herein reported is the first case that associates sleep abnormalities and multiple SOREMPs with HPP. Furthermore, the present case suggests that SOREMPs may be explained by an increased extracellular potassium conductance related to HPP.

  12. Periodically poled silicon

    NASA Astrophysics Data System (ADS)

    Hon, Nick K.; Tsia, Kevin K.; Solli, Daniel R.; Jalali, Bahram

    2009-03-01

    We propose a new class of photonic devices based on periodic stress fields in silicon that enable second-order nonlinearity as well as quasi-phase matching. Periodically poled silicon (PePSi) adds the periodic poling capability to silicon photonics and allows the excellent crystal quality and advanced manufacturing capabilities of silicon to be harnessed for devices based on second-order nonlinear effects. As an example of the utility of the PePSi technology, we present simulations showing that midwave infrared radiation can be efficiently generated through difference frequency generation from near-infrared with a conversion efficiency of 50%.

  13. Genealogy of periodic trajectories

    SciTech Connect

    de Adguiar, M.A.M.; Maldta, C.P.; de Passos, E.J.V.

    1986-05-20

    The periodic solutions of non-integrable classical Hamiltonian systems with two degrees of freedom are numerically investigated. Curves of periodic families are given in plots of energy vs. period. Results are presented for this Hamiltonian: H = 1/2(p/sub x//sup 2/ + p/sub y//sup 2/) + 1/2 x/sup 2/ + 3/2 y/sup 2/ - x/sup 2/y + 1/12 x/sup 4/. Properties of the families of curves are pointed out. (LEW)

  14. Periodized Daubechies wavelets

    SciTech Connect

    Restrepo, J.M.; Leaf, G.K.; Schlossnagle, G.

    1996-03-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrated by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and their use ius illustrated in the approximation of two commonly used differential operators. The periodization of the connection coefficients in Galerkin schemes is presented in detail.

  15. Subcutaneous C.E.R.A. for the Treatment of Chronic Renal Anemia in Predialysis Patients

    PubMed Central

    Üstündağ, Sedat; Doğan, Ekrem; Duranay, Murat; Kazancıoğlu, Rümeyza; Çelik, Vedat; Ünsal, Abdülkadir; Altıntepe, Lütfullah; Dursun, Belda; Akbaş, Ertuğrul; Özdener, Fatih; Yıldız, Alaattin

    2016-01-01

    Background: We investigated the efficacy, safety and tolerability of once-monthly administration of C.E.R.A. in erythropoiesis stimulating agents (ESAs) naive predialysis patients with CKD for anemia treatment Study Design: Single arm, open label study. Methods: A total of 75 patients (mean (SD) age was 52.8 (16.4) years, 76.0% were female) were included in this study conducted between 12 August 2008 and 30 October 2009 in 9 centers across Turkey. The mean change in Hb concentration (g/dL) between baseline (week 0) and the efficacy evaluation period (EEP) was the primary efficacy parameter evaluated in three consecutive periods including a dose titration period (DTP; with initial 1.2 μg/kg dose of C.E.R.A., subcutaneously, 28 weeks), EEP (8 weeks) and a long-term safety period (16 weeks). Results: Our analysis revealed an improvement in Hb levels from baseline value of 9.4 (0.4) g/dL to time adjusted average level of 11.4 (0.7) g/dL in EEP in the per protocol (PP) population and from 9.3 (0.5) g/dL to 11.1 (1.0) g/dL in intent-to-treat (ITT) population. Mean (SD) change in Hb levels from baseline to EEP was 2.0 (0.7) g/dl in the PP population (primary endpoint) and 1.7 (1.1) g/dL in the ITT population. The percentage of patients whose Hb concentrations remained within the target range of 10.0–12.0 g/dL throughout the EEP was 43.9% (95% CI: 28.5–60.3%) in the PP population and 38.7% (95% CI: 27.6% to 50.6%) in the ITP population. A total of 206 adverse events (AE) were reported in 77.0% of patients with hypertension (20%) as the most frequent AE. Conclusion: Once-monthly subcutaneous C.E.R.A. administration is effective and safe in the treatment of anemia in pre-dialysis patients with CKD, who are not currently treated with ESAs. PMID:27308077

  16. Your First Period

    MedlinePlus

    ... severe asthma). Always follow the directions on the bottle about how much to take. Exercise. Place a ... days. Glossary Amenorrhea: The absence of menstrual periods. Egg: The female reproductive cell produced in and released ...

  17. The Periodic Table CD.

    ERIC Educational Resources Information Center

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  18. Setting the Periodic Table.

    ERIC Educational Resources Information Center

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  19. Thyrotoxic periodic paralysis

    MedlinePlus

    ... high levels of thyroid hormone in their blood ( hyperthyroidism , thyrotoxicosis). Causes This is a rare condition that ... include a family history of periodic paralysis and hyperthyroidism. Symptoms Symptoms involve attacks of muscle weakness or ...

  20. A periodic table for cancer.

    PubMed

    Epstein, Richard J

    2015-01-01

    Cancers exhibit differences in metastatic behavior and drug sensitivity that correlate with certain tumor-specific variables such as differentiation grade, growth rate/extent and molecular regulatory aberrations. In practice, patient management is based on the past results of clinical trials adjusted for these biomarkers. Here, it is proposed that treatment strategies could be fine-tuned upfront simply by quantifying tumorigenic spatial (cell growth) and temporal (genetic stability) control losses, as predicted by genetic defects of cell-cycle-regulatory gatekeeper and genome-stabilizing caretaker tumor suppressor genes, respectively. These differential quantifications of tumor dysfunction may in turn be used to create a tumor-specific 'periodic table' that guides rational formulation of survival-enhancing anticancer treatment strategies.

  1. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.266 Period covered by periodic MIP. The initial MIP shall cover the period...

  2. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.266 Period covered by periodic MIP. The initial MIP shall cover the period...

  3. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.266 Period covered by periodic MIP. The initial MIP shall cover the period...

  4. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.266 Period covered by periodic MIP. The initial MIP shall cover the period...

  5. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.266 Period covered by periodic MIP. The initial MIP shall cover the period...

  6. Hyperthyroid hypokalemic periodic paralysis.

    PubMed

    Neki, N S

    2016-01-01

    Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like propranol can also be used to ameliorate and prevent subsequent paralytic attack. We report a case of 22 year old male presenting with hyperthyroid periodic paralysis (HPP) having very low serum potassium level. PMID:27648066

  7. Periodically kicked turbulence

    PubMed

    Lohse

    2000-10-01

    Periodically kicked turbulence is theoretically analyzed within a mean-field theory. For large enough kicking strength A and kicking frequency f the Reynolds number grows exponentially and then runs into some saturation. The saturation level Re(sat) can be calculated analytically; different regimes can be observed. For large enough Re we find Re(sat) approximately Af, but intermittency can modify this scaling law. We suggest an experimental realization of periodically kicked turbulence to study the different regimes we theoretically predict and thus to better understand the effect of forcing on fully developed turbulence. PMID:11089041

  8. Hyperthyroid hypokalemic periodic paralysis

    PubMed Central

    Neki, N.S.

    2016-01-01

    Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like propranol can also be used to ameliorate and prevent subsequent paralytic attack. We report a case of 22 year old male presenting with hyperthyroid periodic paralysis (HPP) having very low serum potassium level. PMID:27648066

  9. Spontaneous periodic hypothermia.

    PubMed

    Kloos, R T

    1995-09-01

    Spontaneous periodic hypothermia is a rare syndrome of recurrent, centrally mediated hypothermia without an identifiable systemic cause or brain lesion. Most patients defend a temporarily lowered temperature "set point" during episodes of hypothermia, despite manifesting many well-known systemic consequences of core temperature hypothermia. No case of death directly attributable to an episode of spontaneous periodic hypothermia has been reported, although many of the serious systemic effects of hypothermia have been documented in these cases, so it is not unlikely that death may occur. The syndrome's cause, and that of Shapiro syndrome, remains unknown. Pharmacologic trials to date have been only modestly successful. Anticonvulsant agents, clonidine, and cyproheptadine appear the most likely to succeed, with cyproheptadine being a reasonable first choice. Given that the term "spontaneous periodic hypothermia" describes a syndrome, and not a pathophysiologic mechanism, it is likely to encompass a common eventuality, arrived at via several different pathways. One can postulate mechanisms such as structural abnormalities, trauma, infection, irritation, and degeneration involving strategic locations which create a focus for epileptic or other periodic dysfunction whose scope involves the centers for thermoregulation. The existence of 2 distinct, oppositional thermoregulatory centers would allow for speculation of similar mechanisms accounting for cases of both periodic hypo- and hyperthermia (61). Postmortem data regarding the hypothalamic and surrounding areas from future cases of Shapiro syndrome and spontaneous periodic hypothermia would be of great interest. Further, more sensitive in vivo testing methods are clearly needed. The role of PET or single photon emission computed tomography (SPECT) with technetium 99m-labeled hexamethylpropylene amine oxime (Tc 99m HMPAO) performed acutely during an episode remains to be characterized (64, 103, 105). The term

  10. Dysmenorrhea: Painful Periods

    MedlinePlus

    ... need surgery. In some cases, a mix of treatments works best. What medications are used to treat dysmenorrhea? Certain pain relievers, called nonsteroidal anti-inflammatory drugs (NSAIDs), target prostaglandins. ...

  11. [Pefloxacin as a first-line treatment for nephrotic syndrome in minimal glomerular lesions in the adult. Multicenter study of 32 patients].

    PubMed

    Pruna, A; Barka, A; Nochy, D; Hauet, T; Boulanger, H; Landais, P

    1997-01-01

    Minimal change nephrotic syndrome (MCNS) is the most frequent single cause of nephrotic syndrome occurring both in adults and children. Although it appears to be a self-limiting disorder (10% spontaneous remissions within the fortnight following the initial flare), MCNS displays a high rate of complications during the nephrotic period (10 to 15% cases) and prompts one to treat patients as early as possible. Corticosteroids are currently used as first-line treatment. A 16 weeks full-dose steroid course (1 mg/kg/day) usually induces remission in 75% MCNS in adults. Nevertheless, duration of treatment (9 months) and occurrence of relapses despite a slowly tapering dosage schedule, expose patients to steroids side-effects. Immunosuppressive drugs are recommended in case of steroid resistance and their side-effects are not harmless. Therefore, an alternative to steroids or immunosuppressives would lend a serious helping hand in MCNS management. The present work is dealing with pefloxacin efficacy in 40% MCNS in adults. Thirty-two MCNS adult patients were treated in a national multicenter study. A short-duration pefloxacin course (4 to 6 weeks) allowed partial or complete remission in 13 out of 32 cases. Thus far, this effect was undescribed for this class of drugs. Pefloxacin belongs to antibacterial agents of the fluoroquinolone family and is active against Gram negative Enterobacteria species. Fluoroquinolones also act on eukaryotic cells as lymphocytes and chondrocytes and alter IL2, gamma IFN and integrin expression. Although their precise mode of action is unknown in this kind of immunological disorder, fluoroquinolones might represent an alternative to steroids in some adult form of MCNS. However, predictive criteria for sensitivity to fluoroquinolones are currently not available and further controlled studies would be helpful using fluoroquinolones as first-line treatment in all the MCNS. PMID:9297136

  12. Periodically poled silicon

    NASA Astrophysics Data System (ADS)

    Hon, Nick K.; Tsia, Kevin K.; Solli, Daniel R.; Khurgin, Jacob B.; Jalali, Bahram

    2010-02-01

    Bulk centrosymmetric silicon lacks second-order optical nonlinearity χ(2) - a foundational component of nonlinear optics. Here, we propose a new class of photonic device which enables χ(2) as well as quasi-phase matching based on periodic stress fields in silicon - periodically-poled silicon (PePSi). This concept adds the periodic poling capability to silicon photonics, and allows the excellent crystal quality and advanced manufacturing capabilities of silicon to be harnessed for devices based on χ(2)) effects. The concept can also be simply achieved by having periodic arrangement of stressed thin films along a silicon waveguide. As an example of the utility, we present simulations showing that mid-wave infrared radiation can be efficiently generated through difference frequency generation from near-infrared with a conversion efficiency of 50% based on χ(2) values measurements for strained silicon reported in the literature [Jacobson et al. Nature 441, 199 (2006)]. The use of PePSi for frequency conversion can also be extended to terahertz generation. With integrated piezoelectric material, dynamically control of χ(2)nonlinearity in PePSi waveguide may also be achieved. The successful realization of PePSi based devices depends on the strength of the stress induced χ(2) in silicon. Presently, there exists a significant discrepancy in the literature between the theoretical and experimentally measured values. We present a simple theoretical model that produces result consistent with prior theoretical works and use this model to identify possible reasons for this discrepancy.

  13. Scheduling: Seven Period Day

    ERIC Educational Resources Information Center

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  14. Periodic Table of Students.

    ERIC Educational Resources Information Center

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  15. A Modern Periodic Table.

    ERIC Educational Resources Information Center

    Herrenden-Harker, B. D.

    1997-01-01

    Presents a modern Periodic Table based on the electron distribution in the outermost shell and the order of filling of the sublevels within the shells. Enables a student to read off directly the electronic configuration of the element and the order in which filling occurs. (JRH)

  16. Getting Your Period

    MedlinePlus

    ... for a woman to have a baby. During sexual intercourse, the egg can get fertilized by a male’s sperm and then attach to the lining of the uterus ( endometrium ) and grow into a baby. ( Read more about reproduction. ) Does your period come each month? top Menstrual ...

  17. Astrophysical implications of periodicity

    NASA Technical Reports Server (NTRS)

    Muller, Richard A.

    1988-01-01

    Two remarkable discoveries of the last decade have profound implications for astrophysics and for geophysics. These are the discovery by Alvarez et al., that certain mass extinctions are caused by the impact on the earth of a large asteroid or comet, and the discovery by Raup and Sepkoski that such extinctions are periodic, with a cycle time of 26 to 30 million years. The validity of both of these discoveries is assumed and the implications are examined. Most of the phenomena described depend not on periodicity, but just on the weaker assumption that the impacts on the earth take place primarily in showers. Proposed explanations for the periodicity include galactic oscillations, the Planet X model, and the possibility of Nemesis, a solar companion star. These hypotheses are critically examined. Results of the search for the solar companion are reported. The Deccan flood basalts of India have been proposed as the impact site for the Cretaceous impact, but this hypotheisis is in contradiction with the conclusion of Courtillot et al., that the magma flow began during a period of normal magnetic field. A possible resolution of this contradiction is proposed.

  18. Evaluation of vardenafil for the treatment of subjective tinnitus: a controlled pilot study

    PubMed Central

    Mazurek, Birgit; Haupt, Heidemarie; Szczepek, Agnieszka J; Sandmann, Jörg; Gross, Johann; Klapp, Burghard F; Kiesewetter, Holger; Kalus, Ulrich; Stöver, Timo; Caffier, Philipp P

    2009-01-01

    Background Vardenafil (Levitra®) represents a potent and highly selective phosphodiesterase type 5 (PDE5) inhibitor, which is established for treatment of various diseases. There are several unpublished reports from patients stating that vardenafil has a considerable therapeutic effect on their concomitant tinnitus. This pilot study was conducted to specifically assess the effect of vardenafil in patients with chronic tinnitus. Methods This trial was based on a prospective, randomized, double-blind, placebo-controlled, parallel group design. Fourty-two consecutive subjects with mon- or binaural chronic tinnitus received 10 mg vardenafil (N = 21) or matching placebo tablets (N = 21) administered orally twice a day over a period of 12 weeks. Clinical examination and data acquisition took place at each visit: at baseline, after 4 weeks, after 12 weeks (end of treatment with study medication), and at non-medicated follow-up after 16 weeks. Assessment of clinical effectiveness was based on a standardized tinnitus questionnaire (TQ), the Short Form 36 health survey (SF-36), audiometric measurements (mode, pitch and loudness of tinnitus; auditory thresholds) and biomarkers of oxidative stress in patients' blood (malondialdehyde, protein carbonyl, homocysteine and total antioxidative status). Therapeutic efficacy was evaluated by comparison of subjective and objective parameters with baseline data between both treatment groups (ANCOVA). Results Vardenafil had no superior efficacy over placebo in the treatment of chronic tinnitus during this study. The primary efficacy criterion 'TQ total score' failed to demonstrate significant improvement compared to placebo. Subjective reports of TQ subscales and general quality of life areas (SF-36), objective audiometric examinations as well as investigated biomarkers for oxidative stress did not reveal any significant treatment effects. The safety profile was favorable and consistent with that in other vardenafil studies. Conclusion

  19. Cells anticipate periodic events

    NASA Astrophysics Data System (ADS)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  20. Periodic minimal surfaces

    NASA Astrophysics Data System (ADS)

    Mackay, Alan L.

    1985-04-01

    A minimal surface is one for which, like a soap film with the same pressure on each side, the mean curvature is zero and, thus, is one where the two principal curvatures are equal and opposite at every point. For every closed circuit in the surface, the area is a minimum. Schwarz1 and Neovius2 showed that elements of such surfaces could be put together to give surfaces periodic in three dimensions. These periodic minimal surfaces are geometrical invariants, as are the regular polyhedra, but the former are curved. Minimal surfaces are appropriate for the description of various structures where internal surfaces are prominent and seek to adopt a minimum area or a zero mean curvature subject to their topology; thus they merit more complete numerical characterization. There seem to be at least 18 such surfaces3, with various symmetries and topologies, related to the crystallographic space groups. Recently, glyceryl mono-oleate (GMO) was shown by Longley and McIntosh4 to take the shape of the F-surface. The structure postulated is shown here to be in good agreement with an analysis of the fundamental geometry of periodic minimal surfaces.

  1. SU-E-J-17: Intra-Fractional Prostate Movement Correction During Treatment Delivery Period for Prostate Cancer Using the Intra-Fractional Orthogonal KV-MV Image Pairs

    SciTech Connect

    Zhang, J; Azawi, S; Cho-Lim, J; Wei, R; Williams, R; Frank, E

    2015-06-15

    Purpose: To evaluate the intra-fractional prostate movement range during the beam delivery and implement new IGRT method to correct the prostate movement during the hypofractionated prostate treatment delivery. Methods: To evaluate the prostate internal motion range during the beam delivery, 11 conventional treatments were utilized. Two-arc RapidArc plans were used for the treatment delivery. Orthogonal KV imaging is performed in the middle of the treatment to correct intra-fractional prostate movement. However, it takes gantry-mounted on-board imaging system relative long time to finish the orthogonal KV imaging because of gantry rotation. To avoid gantry movement and accelerate the IGRT processing time, orthogonal KV-MV image pair is tested using the OBI daily QA Cube phantom. Results: The average prostate movement between two orthogonal KV image pairs was 0.38cm (0.20cm ∼ 0.85cm). And the interval time between them was 6.71 min (4.64min ∼ 9.22 min). 2-arc beam delivery time is within 3 minutes for conventional RapidArc treatment delivery. Hypofractionated treatment or SBRT need 4 partial arc and possible non-coplanar technology, which need much longer beam delivery time. Therefore prostate movement might be larger. New orthogonal KV-MV image pair is a new method to correct the prostate movement in the middle of the beam delivery if real time tracking method is not available. Orthogonal KV-MV image pair doesn’t need gantry rotation. Images were acquired quickly which minimized possible new prostate movement. Therefore orthogonal KV-MV image pair is feasible for IGRT. Conclusion: Hypofractionated prostate treatment with less PTV margin always needs longer beam delivery time. Therefore prostate movement correction during the treatment delivery is critical. Orthogonal KV-MV imaging pair is efficient and accurate to correct the prostate movement during treatment beam delivery. Due to limited fraction number and high dose per fraction, the MV imaging dose is

  2. Attention Reorients Periodically.

    PubMed

    Dugué, Laura; Roberts, Mariel; Carrasco, Marisa

    2016-06-20

    Reorienting of voluntary attention enables the processing of stimuli at previously unattended locations. Although studies have identified a ventral fronto-parietal network underlying attention [1, 2], little is known about whether and how early visual areas are involved in involuntary [3, 4] and even less in voluntary [5] reorienting, and their temporal dynamics are unknown. We used transcranial magnetic stimulation (TMS) over the occipital cortex to interfere with attentional reorienting and study its role and temporal dynamics in this process. Human observers performed an orientation discrimination task, with either valid or invalid attention cueing, across a range of stimulus contrasts. Valid cueing induced a behavioral response gain increase, higher asymptotic performance for attended than unattended locations. During subsequent TMS sessions, observers performed the same task, with high stimulus contrast. Based on phosphene mapping, TMS double pulses were applied at one of various delays to a consistent brain location in retinotopic areas (V1/V2), corresponding to the evoked signal of the target or distractor, in a valid or invalid trial. Thus, the stimulation was identical for the four experimental conditions (valid/invalid cue condition × target/distractor-stimulated). TMS modulation of the target and distractor were both periodic (5 Hz, theta) and out of phase with respect to each other in invalid trials only, when attention had to be disengaged from the distractor and reoriented to the target location. Reorientation of voluntary attention periodically involves V1/V2 at the theta frequency. These results suggest that TMS probes theta phase-reset by attentional reorienting and help link periodic sampling in time and attention reorienting in space.

  3. Controls on geyser periodicity.

    PubMed

    Ingebritsen, S E; Rojstaczer, S A

    1993-11-01

    Geyser eruption frequency is not constant over time and has been shown to vary with small (periodicity. Much of the responsiveness to remote seismicity and other small strains in the Earth can be explained in terms of variations in permeability and lateral recharge rates.

  4. Controls on geyser periodicity

    USGS Publications Warehouse

    Ingebritsen, S.E.; Rojstaczer, S.A.

    1993-01-01

    Geyser eruption frequency is not constant over time and has been shown to vary with small (???10-6) strains induced by seismic events, atmospheric loading, and Earth tides. The geyser system is approximated as a permeable conduit of intensely fractured rock surrounded by a less permeable rock matrix. Numerical simulation of this conceptual model yields a set of parameters that controls geyser existence and periodicity. Much of the responsiveness to remote seismicity and other small strains in the Earth can be explained in terms of variations in permeability and lateral recharge rates.

  5. Controls on geyser periodicity.

    PubMed

    Ingebritsen, S E; Rojstaczer, S A

    1993-11-01

    Geyser eruption frequency is not constant over time and has been shown to vary with small (periodicity. Much of the responsiveness to remote seismicity and other small strains in the Earth can be explained in terms of variations in permeability and lateral recharge rates. PMID:17757358

  6. The postanesthetic period. Complications.

    PubMed

    Malamed, S F

    1987-01-01

    Postanesthetic complications can occur even in the best of circumstances. Proper preparation of the staff, aggressive monitoring of the recovering patient, and early recognition and management of the complications are essential if the outcome is to be successful. In reviewing postanesthetic complications, two factors are present in the overwhelming majority of situations--hypoxia and hypercarbia--often the direct result of inadequate monitoring during the postanesthetic period. The anesthetic procedure is not over once the anesthetic agents are discontinued. The skillful anesthetist is aware of the possibilities of postoperative complications and prevents problems by employing enhanced monitoring techniques during the recovery phase.

  7. Whole Abdominopelvic Radiotherapy Using Intensity-Modulated Arc Therapy in the Palliative Treatment of Chemotherapy-Resistant Ovarian Cancer With Bulky Peritoneal Disease: A Single-Institution Experience

    SciTech Connect

    De Meerleer, Gert; Vandecasteele, Katrien; Ost, Piet; Delrue, Louke; Denys, Hannelore; Makar, Amin; Speleers, Bruno; Van Belle, Simon; Van den Broecke, Rudy; Fonteyne, Valerie; De Neve, Wilfried

    2011-03-01

    Purpose: To retrospectively review our experience with whole abdominopelvic radiotherapy (WAPRT) using intensity-modulated arc therapy in the palliative treatment of chemotherapy-resistant ovarian cancer with bulky peritoneal disease. Methods and Materials: Between April 2002 and April 2008, 13 patients were treated with WAPRT using intensity-modulated arc therapy. We prescribed a dose of 33 Gy to be delivered in 22 fractions of 1.5 Gy to the abdomen and pelvis. All patients had International Federation of Gynecology and Obstetrics Stage III or IV ovarian cancer at the initial diagnosis. At referral, the median age was 61 years, and the patients had been heavily pretreated with surgery and chemotherapy. All patients had symptoms from their disease, including gastrointestinal obstruction or subobstruction in 6, minor gastrointestinal symptoms in 2, pain in 4, ascites in 1, and vaginal bleeding in 2. A complete symptom or biochemical response required complete resolution of the patient's symptoms or cancer antigen-125 level. A partial response required {>=}50% resolution of these parameters. The actuarial survival was calculated from the start of radiotherapy. Results: The median overall survival was 21 weeks, with a 6-month overall survival rate of 45%. The 9 patients who completed treatment obtained a complete symptom response, except for ascites (partial response). The median and mean response duration (all symptoms grouped) was 24 and 37 weeks, respectively. Of the 6 patients presenting with obstruction or subobstruction, 4 obtained a complete symptom response (median duration, 16 weeks). Conclusion: WAPRT delivered using intensity-modulated arc therapy offers important palliation in the case of peritoneal metastatic ovarian cancer. WAPRT resolved intestinal obstruction for a substantial period.

  8. Group Cognitive-Behavioral Therapy for Depression in Spanish: Culture-Sensitive Manualized Treatment in Practice

    PubMed Central

    Aguilera, Adrian; Garza, Monica J.; Muñoz, Ricardo F.

    2014-01-01

    The authors applied cognitive-behavioral therapy (CBT) for depression using the Healthy Management of Reality treatment manual. This 16-week group treatment comprised four 4-week modules: thoughts (cognitive restructuring), activities (behavioral activation), people (interpersonal skills training), and health (addresses physical health and depression). They illustrated the use of the culture-sensitive treatment manuals by way of the member characteristics and clinical process of a Spanish-language CBT group for depression. They highlighted the challenges and satisfactions of working with a Spanish-speaking population in the public sector, and focused on how culture and socioeconomic status influence patients, and how to adapt treatment to these factors. Last, they demonstrated how technological advances integrate with culture-sensitive, evidence-based treatments to better serve this population and reduce disparities. PMID:20549680

  9. 42 CFR 412.426 - Transition period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Transition period. 412.426 Section 412.426 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... inpatient operating costs and capital costs in accordance with part 413 of this chapter. (c) Treatment...

  10. Efficacy of contingency management in improving retention and compliance to methadone maintenance treatment: a random controlled study

    PubMed Central

    Jiang, Haifeng; Du, Jiang; Wu, Fei; Wang, Zhaowei; Fan, Shujun; Li, Zhibin; Hser, Yih-Ing; Zhao, Min

    2012-01-01

    Background Compliance with methadone maintenance treatment (MMT) in China is poor. Objective To evaluate the effects of adjunctive contingency management (CM) on the efficacy of methadone maintenance treatment (MMT) in patients with opioid dependence. Hypothesis A 12-week prize-based contingency management (CM) intervention can increase the retention and compliance of heroin abusers to standardized MMT programs in Shanghai. Methods 160 heroin-dependent patients from three voluntary MMT clinics in Shanghai were randomly assigned to a treatment as usual group (MMT, n=80) and an intervention group (MMT+CM, n=80). Daily use of methadone was recorded and urine drug tests were conducted weekly during the first 12 weeks and then at week 16, week 20 and week 24. Results The 12-week retention rates for the intervention (MMT+CM) and treatment-as-usual (MMT) groups were both quite high: 87.5% and 86.2%, respectively. The average durations of using methadone in the two groups were equal (70 days versus 71 days, respectively). There was a non-significant increase in the mean longest drug-free period (7.4 weeks versus 6.5 weeks) and in the mean number of negative urine tests (7.9 versus 7.6). Secondary analysis of the 24-week outcomes (12 weeks after termination of the adjunctive CM treatment) also found no significant differences between the groups. Among those who remained in the program the severity of addiction as assessed by the Addiction Severity Index decreased dramatically over the 24 weeks but, again, there were no significant differences in the addiction measures between those in the intervention group and those in the treatment-as-usual group. Conclusion Prize-based CM is not effective in improving the retention and compliance of heroin abusers to MMT in Shanghai. The main reasons for failure to replicate western studies were the unexpectedly high baseline rates of compliance in this sample (86%) and the relatively weak financial incentives provided by the CM program

  11. [Clinical study for the evaluation of the tolerability of O-(beta-hydroxy-ethyl)-rutoside in the treatment of hemorrhoids during the 3d trimester of pregnancy and in the postpartum period].

    PubMed

    Benzi, G; Vanzulli, A; Pozzi, E; Acerboni, S

    1992-11-01

    Hemorrhoidal disease is particularly frequent in the last trimester of pregnancy and immediately after birth. The aim of the present study was to evaluate the efficacy and tolerability of high doses of O-(beta-hydroxyethyl)-rutoside in patients affected by this pathology. Forty-two women with hemorrhoid varices of varying severity which had appeared during the last trimester of pregnancy or immediately post-partum were treated by administering 3 g/day of the substance in question for 14 consecutive days. At the start and end of treatment a series of clinical and objective parameters were measured and at the end of treatment efficacy and tolerability were assessed. The latter was found to be excellent; in fact, it was not necessary to suspend treatment in any of the subjects treated. Clinical efficacy, assessed by the researcher, was judged to be positive in 95% of cases treated. Clinical improvements in the parameters examined were statistically significant (p < 0.01). The results obtained confirm the value of oral therapy using O-(beta-hydroxyethyl)-rutoside in pregnant or puerperal patients since the preparation was found to be efficacious and easily managed, above all significantly reducing pain, subjectively the most urgent symptom to be treated.

  12. Update on the treatment of genital warts.

    PubMed

    Scheinfeld, Noah

    2013-06-01

    This review summarizes new treatments from the last seven years employed for the treatment of genital warts caused by human papillomavirus (HPV). Imquimod 3.75% is a new agent with fewer side effects and perhaps a better dosing schedule than imquimod 5%, but is not more effective. Sinecatechins/Polyphenon E 15%, a novel extract from green tea can be effective against genital warts but requires three times a day dosing and is not more effective than existing treatments; the treatment course is 12-16 weeks. Photodynamic therapy combined with other destructive modalities might increase the cure rate for genital warts. The quadrivalent vaccine against HPV 6, 11, 16, 18 is decreasing the incidence of warts in the western world but the evidence does not support vaccination as a treatment for those already infected by HPV. Hyperthermia and immunomodulators might be positive additions to the armamentarium of clinicians. In sum, there are new tools that physicians can use but none is really a great advance over what was available a decade ago. PMID:24011309

  13. Transition from non-periodic to periodic explosions.

    PubMed

    Cartes, Carlos; Descalzi, Orazio

    2015-12-13

    We show the existence of periodic exploding dissipative solitons. These non-chaotic explosions appear when higher-order nonlinear and dispersive effects are added to the complex cubic-quintic Ginzburg-Landau equation modelling soliton transmission lines. This counterintuitive phenomenon is the result of period-halving bifurcations leading to order (periodic explosions), followed by period-doubling bifurcations (or intermittency) leading to chaos (non-periodic explosions). PMID:26527807

  14. Behavioral and Psychosocial Outcomes of a 16-Week Rebound Therapy-Based Exercise Program for People with Profound Intellectual Disabilities

    ERIC Educational Resources Information Center

    Jones, Martyn C.; Walley, Robert M.; Leech, Amanda; Paterson, Marion; Common, Stephanie; Metcalf, Charlotte

    2007-01-01

    People with profound intellectual disabilities rarely experience a physically active lifestyle, and their long-term physical inactivity likely contributes to poor health. The authors developed and implemented a pilot exercise program for persons with a profound intellectual disability and conducted a study to evaluate the effort. The development…

  15. Muscle Volume Increases Following 16 Weeks of Resistive Exercise Training with the Advanced Resistive Exercise Device (ARED) and Free Weights

    NASA Technical Reports Server (NTRS)

    Nash, R. E.; Loehr, J. A.; Lee, S. M. C.; English, K. L.; Evans, H.; Smith, S. A.; Hagan, R. D.

    2009-01-01

    Space flight-induced muscle atrophy, particularly in the postural and locomotorymuscles, may impair task performance during long-duration space missions and planetary exploration. High intensity free weight (FW) resistive exercise training has been shown to prevent atrophy during bed rest, a space flight analog. NASA developed the Advanced Resistive Exercise Device (ARED) to simulate the characteristics of FW exercise (i.e. constant mass, inertial force) and to be used as a countermeasure during International Space Station (ISS) missions. PURPOSE: To compare the efficacy of ARED and FW training to induce hypertrophy in specific muscle groups in ambulatory subjects prior to deploying ARED on the ISS. METHODS: Twenty untrained subjects were assigned to either the ARED (8 males, 3 females) or FW (6 males, 3 females) group and participated in a periodizedtraining protocol consisting of squat (SQ), heel raise (HR), and deadlift(DL) exercises 3 d wk-1 for 16 wks. SQ, HR, and DL muscle strength (1RM) was measured before, after 8 wks, and after 16 wks of training to prescribe exercise and measure strength changes. Muscle volume of the vastigroup (V), hamstring group (H), hip adductor group (ADD), medial gastrocnemius(MG), lateral gastrocnemius(LG), and deep posterior muscles including soleus(DP) was measured using MRI pre-and post-training. Consecutive cross-sectional images (8 mm slices with a 2 mm gap) were analyzed and summed. Anatomical references insured that the same muscle sections were analyzed pre-and post-training. Two-way repeated measures ANOVAs (p<0.05) were used to test for differences in muscle strength and volume between training devices. RESULTS: SQ, HR, and DL 1RM increased in both FW (SQ: 49+/-6%, HR: 12+/-2%, DL: 23+/-4%) and ARED (SQ: 31+/-4%, HR: 18+/-2%, DL: 23+/-3%) groups. Both groups increased muscle volume in the V (FW: 13+/-2%, ARED: 10+/-2%), H (FW: 3+/-1%, ARED: 3+/-1 %), ADD (FW: 15=/-2%, ARED: 10+/-1%), LG (FW: 7+/-2%, ARED: 4+/-1%), MG (FW: 7+/-2%, ARED: 5+/-2%), and DP (FW: 2+/-1%; ARED: 2+/-1%) after training. There were no between group differences in muscle strength or volume. CONCLUSIONS: The increase in muscle volume and strength following ARED training is not different than FW training. With the training effects similar to FW and a 600 lb load capacity, ARED likely will protect against muscle atrophy in microgravity.

  16. [THE ROLE OF MOTHER'S MILK AND BREAST FEEDING. MEDICAL PROBLEMS DURING THE LACTATION PERIOD LACTOBACILUS FERMENTUM--A NEW APPROACH TOWARDS THE PREVENTION AND THE TREATMENT OF ACUTE AND SUBACUTE MASTITIS].

    PubMed

    Popova, B; Mitev, D; Nikolov, A

    2016-01-01

    Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living. Mother's milk is not sterile. There is a 10 year international trial held in Spanish and Finnish universities. It has identified and count all microorganisms in mother's milk (more than 700) and proved that their content and quantity varies according the age of the baby. Mother's milk is a source of lactobacillus for baby's intestines and most of them have probiotic potential. Lactobacillus fermentum Lc40 (hereditum) is isolated from mother's milk. It has a good viability in gastrointestinal system, high level of adhesion to intestinal epithelium cells, produces glutation--strong antioxidant, good antibacterial activity to entero-pathogens and potential of increasing the immunologic response. Clinical trials reveal that Lactobacillus fermentum plays important role to microflora balance of mother's milk in mastitis during lactation. Many trials estimating the efficiency of lactobacillus fermentum in prevention and treatment of acute and subacute mastitis have been carried out. The results of them open a new door in front of us in the treatment of these conditions--treatment with probiotics instead of antibiotics. PMID:27514147

  17. [THE ROLE OF MOTHER'S MILK AND BREAST FEEDING. MEDICAL PROBLEMS DURING THE LACTATION PERIOD LACTOBACILUS FERMENTUM--A NEW APPROACH TOWARDS THE PREVENTION AND THE TREATMENT OF ACUTE AND SUBACUTE MASTITIS].

    PubMed

    Popova, B; Mitev, D; Nikolov, A

    2016-01-01

    Breast feeding provides a lot of short and long-term benefits for the mother and the baby. It prevents the baby of gastrointestinal, urinary and respiratory infections, atopical conditions and assures long-term protection of cardiovascular and metabolic diseases. The breast feeding decreases the risk for the mother of ovary and breast carcinoma and creates a positive emotional bond between the mother and the baby Mother's milk is a species specific; its content is relatively stable regardless of mother's age race, way and place of living. Mother's milk is not sterile. There is a 10 year international trial held in Spanish and Finnish universities. It has identified and count all microorganisms in mother's milk (more than 700) and proved that their content and quantity varies according the age of the baby. Mother's milk is a source of lactobacillus for baby's intestines and most of them have probiotic potential. Lactobacillus fermentum Lc40 (hereditum) is isolated from mother's milk. It has a good viability in gastrointestinal system, high level of adhesion to intestinal epithelium cells, produces glutation--strong antioxidant, good antibacterial activity to entero-pathogens and potential of increasing the immunologic response. Clinical trials reveal that Lactobacillus fermentum plays important role to microflora balance of mother's milk in mastitis during lactation. Many trials estimating the efficiency of lactobacillus fermentum in prevention and treatment of acute and subacute mastitis have been carried out. The results of them open a new door in front of us in the treatment of these conditions--treatment with probiotics instead of antibiotics.

  18. Periodically oscillating plasma sphere

    SciTech Connect

    Park, J.; Nebel, R.A.; Stange, S.; Murali, S. Krupakar

    2005-05-15

    The periodically oscillating plasma sphere, or POPS, is a novel fusion concept first proposed by D. C. Barnes and R. A. Nebel [Fusion Technol. 38, 28 (1998)]. POPS utilizes the self-similar collapse of an oscillating ion cloud in a spherical harmonic oscillator potential well formed by electron injection. Once the ions have been phase-locked, their coherent motion simultaneously produces very high densities and temperatures during the collapse phase of the oscillation. A requirement for POPS is that the electron injection produces a stable harmonic oscillator potential. This has been demonstrated in a gridded inertial electrostatic confinement device and verified by particle simulation. Also, the POPS oscillation has been confirmed experimentally through observation that the ions in the potential well exhibit resonance behavior when driven at the POPS frequency. Excellent agreement between the observed POPS frequencies and the theoretical predictions has been observed for a wide range of potential well depths and three different ion species. Practical applications of POPS require large plasma compressions. These large compressions have been observed in particle simulations, although space charge neutralization remains a major issue.

  19. [Bibliometry of biomedical periodicals].

    PubMed

    Similowski, T; Derenne, J P

    1995-01-01

    Bibliometry or the science citation index is a quantitative evaluation of periodical literature, biomedical or others. It depends above all on an analysis of citations which allows for a calculation of different indices characterising and classifying journals (number of articles published, frequency of citation, impact, topicality...). The applications of bibliometry are varied from the administration of library collections to the appreciation of the significance of a review in its own speciality area. By extension the bibliometry index are sometimes used to evaluate the importance of a discipline in the literature, the place of a nation within a discipline, the significance of certain opinions or the quality of research. The intrinsic limits of bibliometry are such that this last application should be handled with caution. In effect, various biases can mechanically affect the value of different indices and particularly the fact that an article appearing in a prestigious review should not prejudge its quality such as the relevance of the question posed, the validity of the methodology employed or the accuracy of the results. For this, the study of citations is insufficient and some qualitative or semi-quantitative criteria bearing on the contents of the article should be used (critical reading, gate analysis, etc.) This general review has, as its aim, to expose both the definitions and limits of bibliometry illustrating them with some information calculated from the principal respiratory journals.

  20. A novel surface treatment for porous metallic implants that improves the rate of bony ongrowth.

    PubMed

    Shannon, Fintan J; Cottrell, Jocelyn M; Deng, Xiang-Hua; Crowder, Katherine N; Doty, Stephen B; Avaltroni, Michael J; Warren, Russell F; Wright, Timothy M; Schwartz, Jeffrey

    2008-09-15

    Rapid implant fixation could prove beneficial in a host of clinical applications from total joint arthroplasty to trauma. We hypothesized that a novel self-assembled monolayer of phosphonate molecules (SAMP) covalently bonded to the oxide surface of titanium alloy would enhance bony integration. Beaded metallic rods were treated with one of three coatings: SAMP, SAMP + RGD peptide, or hydroxyapatite. Rods were inserted retrogradely into both distal femurs of 60 rabbits. Fifteen rabbits were sacrificed at 2, 4, 8, and 16 weeks. At each time, seven specimens for mechanical pull-out testing and three for histomorphometric analysis were available for each coating. At four weeks, both SAMP groups had significantly higher failure loads when compared to hydroxyapatite (p < 0.01). No significant differences were found among groups at other times, though the SAMP-alone group remained stronger at 16 weeks. Histology showed abundant new bone formation around all the three groups, though more enhanced formation was apparent in the two SAMP groups. With this novel treatment, with or without RGD, the failure load of implants doubled in half the time as compared with hydroxyapatite. Where early implant fixation is important, the SAMP treatment provides a simple, cost-effective enhancement to bony integration of orthopaedic implants.

  1. Evaluation of ammonium lactate in the treatment of seborrheic keratoses.

    PubMed

    Klaus, M V; Wehr, R F; Rogers, R S; Russell, T J; Krochmal, L

    1990-02-01

    A double-blind, paired comparison study was used to evaluate treatment effects of 12% ammonium lactate lotion (Lac-Hydrin) against its vehicle on seborrheic keratoses. Fifty-eight volunteer patients, 37 to 82 years of age, were studied for 16 weeks. The patients had a minimum of two seborrheic keratoses at least 10 cm apart. They applied the medication twice daily. The lesions were evaluated for height, surface characteristics, color, and length with the use of 7X calibrated loupe, a template, skin replicas, and scanning electron microscopy. Lac-Hydrin 12% lotion significantly reduced the height (elevation) of seborrheic keratoses, and two seborrheic keratoses cleared completely; however, there was no statistically significant difference in the length, color, and surface characteristics between the study group and the control group. Skin replicas and scanning electron microscopy can be used to evaluate lesion surface characteristics, dimensions, and therapeutic effects.

  2. Psychodynamic group treatment of posttraumatic stress disorder in Vietnam veterans.

    PubMed

    Koller, P; Marmar, C R; Kanas, N

    1992-04-01

    Exposure to combat frequently imparts a sense of aloneness, guilt, and helplessness. These and other intrapsychic and interpersonal issues need to be addressed in treating Vietnam veterans suffering from posttraumatic stress disorder (PTSD). Group therapy is proposed as a core treatment modality for dealing with these problems. A model is proposed in which patients are treated for 1 year or more in weekly groups that meet for 16-week sequential segments. Clinical guidelines are made explicit to new members by the co-therapists. Discussion topics deal not only with traumatic experiences related to combat, but also with important pre- and postwar issues that are relevant to the symptoms of PTSD. Timely integration and working through of these issues in the group is critical. PMID:1572783

  3. The redoubtable ecological periodic table

    EPA Science Inventory

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  4. New Galactic Double Periodic Variables

    NASA Astrophysics Data System (ADS)

    Mennickent, R. E.; Rosales, J.

    2014-10-01

    We discovered two new Double Periodic Variables in the ASAS catalogue of variable stars, viz., V495 Cen and V4142 Sgr. Other 3 candidates for Double Periodic Variables were found. All systems have relatively long orbital periods. We present improved ephemerides and disentangled light curves.

  5. 75 FR 1301 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Proposed rule... rulemaking proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1... Docket No. RM2009-10, Order on Analytical Principles Used in Periodic Reporting (Proposals Three...

  6. Cholestasis beyond the Neonatal and Infancy Periods.

    PubMed

    Khalaf, Racha; Phen, Claudia; Karjoo, Sara; Wilsey, Michael

    2016-03-01

    Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods. PMID:27066444

  7. Cholestasis beyond the Neonatal and Infancy Periods

    PubMed Central

    Khalaf, Racha; Phen, Claudia; Karjoo, Sara

    2016-01-01

    Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods. PMID:27066444

  8. Comparison of established and innovative weight-reduction treatment procedures.

    PubMed

    Loro, A D; Fisher, E B; Levenkron, J C

    1979-01-01

    A central component of a commonly used weight-loss procedure developed by Stuart (1967), which emphasizes situational engineering (SE), was compared to eating behavior control (EBC), a treatment employing reinforcement of changes in eating habits. A third treatment encouraged development of individuals' own applications of a model of self-control and attempted to provide effective feedback regarding progress toward weight-loss goals. This self-initiated treatment (SI) was designed to be less directive than many behavioral treatment packages and to be more realistic about the expectations of subjects and the actual eating habits of overweight and normalweight people. Following baseline, treatment lasted six weeks and followup lasted 16 weeks. While all treatments produced weight losses, EBC surpassed SE during treatment. SI losses during treatment did not differ from SE or EBC, but SI was the only group that lost weight throughout followup, indicating the possible utility of more subtle, less directive interventions than those that have often been associated with behavioral approaches. The results of SE question the applicability to clinical procedures of the external cue hypersensitivity theory of obesity (Schachter and Rodin, 1974), to which SE is closely related.

  9. An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis.

    PubMed

    Paccou, Julien; Flipo, René-Marc

    2016-01-01

    Golimumab (Simponi(®)) is a fully human tumor necrosis factor α inhibitor (TNFi) antibody administered subcutaneously. In the European Union, golimumab is indicated for the treatment of adults with severe, active axial spondyloarthritis (axSpA), which includes both ankylosing spondylitis (AS) and nonradiographic axSpA (nr-axSpA). In the US, it is indicated for the treatment of adults with active AS only. This article reviews the efficacy and tolerability of golimumab in nr-axSpA patients compared to other TNFi agents (adalimumab, infliximab, etanercept, and certolizumab pegol). In one ongoing, well-designed controlled study (GO-AHEAD), data at 16 weeks showed that treatment with golimumab (50 mg every 4 weeks) was effective in improving the clinical signs and symptoms of disease in nr-axSpA patients. In addition, 16 weeks of treatment with golimumab reduced inflammation in the sacroiliac joints and spine in patients with nr-axSpA. Moreover, objective evidence of active inflammation at baseline, such as a positive magnetic resonance imaging scan and/or an elevated CRP level, was a good predictor of treatment response to golimumab. Golimumab was generally well tolerated in this study, with a tolerability profile consistent with that seen in previous clinical trials for other indications. Although additional long-term data are needed, current evidence indicates that golimumab is an effective option for the treatment of nr-axSpA. However, in the absence of comparative head-to-head trials, there is no recommended hierarchy for the first prescription of a TNFi agent for the treatment of either nr-axSpA or AS.

  10. An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis

    PubMed Central

    Paccou, Julien; Flipo, René-Marc

    2016-01-01

    Golimumab (Simponi®) is a fully human tumor necrosis factor α inhibitor (TNFi) antibody administered subcutaneously. In the European Union, golimumab is indicated for the treatment of adults with severe, active axial spondyloarthritis (axSpA), which includes both ankylosing spondylitis (AS) and nonradiographic axSpA (nr-axSpA). In the US, it is indicated for the treatment of adults with active AS only. This article reviews the efficacy and tolerability of golimumab in nr-axSpA patients compared to other TNFi agents (adalimumab, infliximab, etanercept, and certolizumab pegol). In one ongoing, well-designed controlled study (GO-AHEAD), data at 16 weeks showed that treatment with golimumab (50 mg every 4 weeks) was effective in improving the clinical signs and symptoms of disease in nr-axSpA patients. In addition, 16 weeks of treatment with golimumab reduced inflammation in the sacroiliac joints and spine in patients with nr-axSpA. Moreover, objective evidence of active inflammation at baseline, such as a positive magnetic resonance imaging scan and/or an elevated CRP level, was a good predictor of treatment response to golimumab. Golimumab was generally well tolerated in this study, with a tolerability profile consistent with that seen in previous clinical trials for other indications. Although additional long-term data are needed, current evidence indicates that golimumab is an effective option for the treatment of nr-axSpA. However, in the absence of comparative head-to-head trials, there is no recommended hierarchy for the first prescription of a TNFi agent for the treatment of either nr-axSpA or AS. PMID:27468228

  11. An appraisal of golimumab in the treatment of severe, active nonradiographic axial spondyloarthritis.

    PubMed

    Paccou, Julien; Flipo, René-Marc

    2016-01-01

    Golimumab (Simponi(®)) is a fully human tumor necrosis factor α inhibitor (TNFi) antibody administered subcutaneously. In the European Union, golimumab is indicated for the treatment of adults with severe, active axial spondyloarthritis (axSpA), which includes both ankylosing spondylitis (AS) and nonradiographic axSpA (nr-axSpA). In the US, it is indicated for the treatment of adults with active AS only. This article reviews the efficacy and tolerability of golimumab in nr-axSpA patients compared to other TNFi agents (adalimumab, infliximab, etanercept, and certolizumab pegol). In one ongoing, well-designed controlled study (GO-AHEAD), data at 16 weeks showed that treatment with golimumab (50 mg every 4 weeks) was effective in improving the clinical signs and symptoms of disease in nr-axSpA patients. In addition, 16 weeks of treatment with golimumab reduced inflammation in the sacroiliac joints and spine in patients with nr-axSpA. Moreover, objective evidence of active inflammation at baseline, such as a positive magnetic resonance imaging scan and/or an elevated CRP level, was a good predictor of treatment response to golimumab. Golimumab was generally well tolerated in this study, with a tolerability profile consistent with that seen in previous clinical trials for other indications. Although additional long-term data are needed, current evidence indicates that golimumab is an effective option for the treatment of nr-axSpA. However, in the absence of comparative head-to-head trials, there is no recommended hierarchy for the first prescription of a TNFi agent for the treatment of either nr-axSpA or AS. PMID:27468228

  12. Evolutionary ecology of periodical insects.

    PubMed

    Heliövaara, K; Väisänen, R; Simon, C

    1994-12-01

    To be periodical, a species must have a fixed life cycle length and adults must appear synchronously, reproduce only once, and die. The consequence of this life history is that, at a given location, adults of a periodical species will be absent or rare in some years and abundant in others. The relative scarcity of periodical Insect species suggests that periodicity does not evolve easily. The major obstacle to its evolution is selection favoring life cycles In which the offspring of any given female appear over a two- or three-year period. Chance events which disrupt this 'bet-hedging' strategy set the stage for periodicity. Mathematical models predict that, given certain initial conditions, intraspecific competition and predation favor its development. Recent studies suggest that periodicity is rarely perfect but that it can persist in the face of limited gene flow through time.

  13. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    NASA Astrophysics Data System (ADS)

    Lin, Wei; Chen, Tianping

    2005-01-01

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  14. Fractional-period excitations in continuum periodic systems

    SciTech Connect

    Nistazakis, H. E.; Frantzeskakis, D. J.; Porter, Mason A.; Kevrekidis, P. G.; Nicolin, A.; Chin, J. K.

    2006-12-15

    We investigate the generation of fractional-period states in continuum periodic systems. As an example, we consider a Bose-Einstein condensate confined in an optical-lattice potential. We show that when the potential is turned on nonadiabatically, the system explores a number of transient states whose periodicity is a fraction of that of the lattice. We illustrate the origin of fractional-period states analytically by treating them as resonant states of a parametrically forced Duffing oscillator and discuss their transient nature and potential observability.

  15. Dynamics of Coulombic and gravitational periodic systems.

    PubMed

    Kumar, Pankaj; Miller, Bruce N

    2016-04-01

    We study the dynamics and the phase-space structures of Coulombic and self-gravitating versions of the classical one-dimensional three-body system with periodic boundary conditions. We demonstrate that such a three-body system may be reduced isomorphically to a spatially periodic system of a single particle experiencing a two-dimensional potential on a rhombic plane. For the case of both Coulombic and gravitational versions, exact expressions of the Hamiltonian have been derived in rhombic coordinates. We simulate the phase-space evolution through an event-driven algorithm that utilizes analytic solutions to the equations of motion. The simulation results show that the motion exhibits chaotic, quasiperiodic, and periodic behaviors in segmented regions of the phase space. While there is no evidence of global chaos in either the Coulombic or the gravitational system, the former exhibits a transition from a completely nonchaotic phase space at low energies to a mixed behavior. Gradual yet striking transitions from mild to intense chaos are indicated with changing energy, a behavior that differentiates the spatially periodic systems studied in this Rapid Communication from the well-understood free-boundary versions of the three-body problem. Our treatment of the three-body systems opens avenues for analysis of the dynamical properties exhibited by spatially periodic versions of various classes of systems studied in plasma and gravitational physics as well as in cosmology. PMID:27176238

  16. Dynamics of Coulombic and gravitational periodic systems

    NASA Astrophysics Data System (ADS)

    Kumar, Pankaj; Miller, Bruce N.

    2016-04-01

    We study the dynamics and the phase-space structures of Coulombic and self-gravitating versions of the classical one-dimensional three-body system with periodic boundary conditions. We demonstrate that such a three-body system may be reduced isomorphically to a spatially periodic system of a single particle experiencing a two-dimensional potential on a rhombic plane. For the case of both Coulombic and gravitational versions, exact expressions of the Hamiltonian have been derived in rhombic coordinates. We simulate the phase-space evolution through an event-driven algorithm that utilizes analytic solutions to the equations of motion. The simulation results show that the motion exhibits chaotic, quasiperiodic, and periodic behaviors in segmented regions of the phase space. While there is no evidence of global chaos in either the Coulombic or the gravitational system, the former exhibits a transition from a completely nonchaotic phase space at low energies to a mixed behavior. Gradual yet striking transitions from mild to intense chaos are indicated with changing energy, a behavior that differentiates the spatially periodic systems studied in this Rapid Communication from the well-understood free-boundary versions of the three-body problem. Our treatment of the three-body systems opens avenues for analysis of the dynamical properties exhibited by spatially periodic versions of various classes of systems studied in plasma and gravitational physics as well as in cosmology.

  17. On the Period-Amplitude and Amplitude-Period Relationships

    NASA Technical Reports Server (NTRS)

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    Examined are Period-Amplitude and Amplitude-Period relationships based on the cyclic behavior of the 12-month moving averages of monthly mean sunspot numbers for cycles 0.23, both in terms of Fisher's exact tests for 2x2 contingency tables and linear regression analyses. Concerning the Period-Amplitude relationship (same cycle), because cycle 23's maximum amplitude is known to be 120.8, the inferred regressions (90-percent prediction intervals) suggest that its period will be 131 +/- 24 months (using all cycles) or 131 +/- 18 months (ignoring cycles 2 and 4, which have the extremes of period, 108 and 164 months, respectively). Because cycle 23 has already persisted for 142 months (May 1996 through February 2008), based on the latter prediction, it should end before September 2008. Concerning the Amplitude-Period relationship (following cycle maximum amplitude versus preceding cycle period), because cycle 23's period is known to be at least 142 months, the inferred regressions (90-percent prediction intervals) suggest that cycle 24's maximum amplitude will be about less than or equal to 96.1 +/- 55.0 (using all cycle pairs) or less than or equal to 91.0 +/- 36.7 (ignoring statistical outlier cycle pairs). Hence, cycle 24's maximum amplitude is expected to be less than 151, perhaps even less than 128, unless cycle pair 23/24 proves to be a statistical outlier.

  18. From Periodic Properties to a Periodic Table Arrangement

    ERIC Educational Resources Information Center

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  19. Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor?

    PubMed

    Goekint, Maaike; Roelands, Bart; De Pauw, Kevin; Knaepen, Kristel; Bos, Inge; Meeusen, Romain

    2010-12-17

    Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins promoting cognitive function and contributing to neurogenesis and neuroprotection. Available evidence suggests that exercise influences serum BDNF concentrations, but that the effect is transient. The purpose of this study is to determine whether a period of aerobic training, followed by a period of detraining, can influence basal serum BDNF levels in humans. Sixteen young, sedentary subjects were assigned to an experimental group (n=9) and a control group (n=7). The experimental group performed an aerobic training program during 8 weeks, followed by 8 weeks of detraining, during which subjects returned to their previous, sedentary activity level. The control group remained physically inactive during 16 weeks. In both groups, performance on short-term (Digit Span test) and mid-term memory (Recall of Images) was assessed. Aerobic training significantly increased the VO(2) peak in the experimental group, and these values returned to baseline after 8 weeks of detraining. Basal serum BDNF was not influenced by 8 weeks of aerobic training and detraining did not seem to have an effect on basal peripheral BDNF concentrations. Both training and detraining did not clearly influence short-term memory performance on the Digit Span test and no differences were present between the experimental and control group on the mid-term memory test. Future studies should focus on patient groups and elderly to further investigate the effect of training and detraining on neurotrophic factors and cognitive function, and on the effects of training and detraining on the BDNF response to acute exercise.

  20. Changing Periods of ST Puppis

    NASA Astrophysics Data System (ADS)

    Walker, S.; Butterworth, N.; Pearce, A.

    2015-12-01

    ST Puppis is a reasonably bright W Virginis variable star, a Type 2 Cepheid with a record of substantial and erratic period changes—21 during the interval 1900 to 1985 with a range of magnitude from 17.4 to 19.2. It was observed as part of Variable Stars South's Cepheid project by Butterworth in 2014 and 2015 using DSLR photometry in BGR passbands and visually by Pearce in 2015. The known period changes are shown graphically and doubtful ones examined and discarded if necessary. With its period and amplitude with a frequently changing period it is a suitable and worthwhile object for visual observing.

  1. Assessing Periodicity of Periodic Leg Movements During Sleep

    PubMed Central

    Rummel, Christian; Gast, Heidemarie; Schindler, Kaspar; Müller, Markus; Amor, Frédérique; Hess, Christian W.; Mathis, Johannes

    2010-01-01

    Background: Periodic leg movements (PLM) during sleep consist of involuntary periodic movements of the lower extremities. The debated functional relevance of PLM during sleep is based on correlation of clinical parameters with the PLM index (PLMI). However, periodicity in movements may not be reflected best by the PLMI. Here, an approach novel to the field of sleep research is used to reveal intrinsic periodicity in inter movement intervals (IMI) in patients with PLM. Methods: Three patient groups of 10 patients showing PLM with OSA (group 1), PLM without OSA or RLS (group 2) and PLM with RLS (group 3) are considered. Applying the “unfolding” procedure, a method developed in statistical physics, enhances or even reveals intrinsic periodicity of PLM. The degree of periodicity of PLM is assessed by fitting one-parameter distributions to the unfolded IMI distributions. Finally, it is investigated whether the shape of the IMI distributions allows to separate patients into different groups. Results: Despite applying the unfolding procedure, periodicity is neither homogeneous within nor considerably different between the three clinically defined groups. Data-driven clustering reveals more homogeneous and better separated clusters. However, they consist of patients with heterogeneous demographic data and comorbidities, including RLS and OSA. Conclusions: The unfolding procedure may be necessary to enhance or reveal periodicity. Thus this method is proposed as a pre-processing step before analyzing PLM statistically. Data-driven clustering yields much more reasonable results when applied to the unfolded IMI distributions than to the original data. Despite this effort no correlation between the degree of periodicity and demographic data or comorbidities is found. However, there are indications that the nature of the periodicity might be determined by long-range interactions between LM of patients with PLM and OSA. PMID:20948585

  2. Time domain period determination techniques

    NASA Technical Reports Server (NTRS)

    Stellingwerf, R. F.

    1980-01-01

    Two simple period determination schemes are discussed. They are well suited to problems involving non-sinusoidal periodic phenomena sampled at a few irregularly spaced points. Statistical properties are discussed. The techniques are applied to the double mode Cepheids BK Cen and TU Cas as test cases.

  3. 76 FR 297 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Notice of proposed... a proposed change in certain analytical methods used in periodic reporting. This action responds to... INFORMATION: Regulatory History, 75 FR 58449 (Sept. 24, 2010). On December 20, 2010, the Postal Service...

  4. 75 FR 7426 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Advance notice of...-789-6820 or stephen.sharfman@prc.gov . SUPPLEMENTARY INFORMATION: Table of Contents I. Background II... approved for use in periodic reporting.\\1\\ The Postal Service labels its proposal ``Proposal One''...

  5. Latino Periodicals: A Selection Guide.

    ERIC Educational Resources Information Center

    Guerena, Salvador, Ed.; Pisano, Vivian M., Ed.

    This guide is a collection development tool of national scope for librarians who need in-depth coverage of Latino periodicals suitable for public, school, and academic libraries. Periodicals evaluated include general interest and popular magazines and newspapers that appeal to Spanish-speaking, bilingual, and English-speaking library patrons and…

  6. 76 FR 296 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... consider a proposed change in certain analytical methods used in periodic reporting. The proposed change... rulemaking proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1... Requesting Initiation of a Proceeding to Consider Proposed Changes in Analytic Principles (Proposals...

  7. 76 FR 52915 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... informal rulemaking on proposed changes in certain analytical methods used in periodic reporting. The... rulemaking proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1... Proposed Changes in Analytical Principles (Proposals Four-Eight), August 8, 2011 (Petition). Proposal...

  8. Forward Period Analysis Method of the Periodic Hamiltonian System

    PubMed Central

    Wang, Pengfei

    2016-01-01

    Using the forward period analysis (FPA), we obtain the period of a Morse oscillator and mathematical pendulum system, with the accuracy of 100 significant digits. From these results, the long-term [0, 1060] (time unit) solutions, ranging from the Planck time to the age of the universe, are computed reliably and quickly with a parallel multiple-precision Taylor series (PMT) scheme. The application of FPA to periodic systems can greatly reduce the computation time of long-term reliable simulations. This scheme provides an efficient way to generate reference solutions, against which long-term simulations using other schemes can be tested. PMID:27727295

  9. Heterogeneity of neural mechanisms of response to pivotal response treatment

    PubMed Central

    Ventola, Pamela; Yang, Daniel Y. J.; Friedman, Hannah E.; Oosting, Devon; Wolf, Julie; Sukhodolsky, Denis G.; Pelphrey, Kevin A.

    2016-01-01

    We investigated the mechanisms by which Pivotal Response Treatment (PRT) improves social communication in a case series of 10 preschool-aged children with Autism Spectrum Disorder (ASD). Functional magnetic resonance imaging (fMRI) identified brain responses during a biological motion perception task conducted prior to and following 16 weeks of PRT treatment. Overall, the neural systems supporting social perception in these 10 children were malleable through implementation of PRT; following treatment, neural responses were more similar to those of typically developing children (TD). However, at baseline, half of the children exhibited hypoactivation, relative to a group of TD children, in the right posterior superior temporal sulcus (pSTS), and half exhibited hyperactivation in this region. Strikingly, the groups exhibited differential neural responses to treatment: The five children who exhibited hypoactivation at baseline evidenced increased activation in components of the reward system including the ventral striatum and putamen. The five children who exhibited hyperactivation at baseline evidenced decreased activation in subcortical regions critical for regulating the flow of stimulation and conveying signals of salience to the cortex—the thalamus, amygdala, and hippocampus. Our results support further investigation into the differential effects of particular treatment strategies relative to specific neural targets. Identification of treatment strategies that address the patterns of neural vulnerability unique to each patient is consistent with the priority of creating individually tailored interventions customized to the behavioral and neural characteristics of a given person. PMID:25370452

  10. Periodic and aperiodic synchronization in skilled action.

    PubMed

    Cummins, Fred

    2011-01-01

    Synchronized action is considered as a manifestation of shared skill. Most synchronized behaviors in humans and other animals are based on periodic repetition. Aperiodic synchronization of complex action is found in the experimental task of synchronous speaking, in which naive subjects read a common text in lock step. The demonstration of synchronized behavior without a periodic basis is presented as a challenge for theoretical understanding. A unified treatment of periodic and aperiodic synchronization is suggested by replacing the sequential processing model of cognitivist approaches with the more local notion of a task-specific sensorimotor coordination. On this view, skilled action is the imposition of constraints on the co-variation of movement and sensory flux such that the boundary conditions that define the skill are met. This non-cognitivist approach originates in the work of John Dewey. It allows a unification of the treatment of sensorimotor synchronization in simple rhythmic behavior and in complex skilled behavior and it suggests that skill sharing is a uniquely human trait of considerable import.

  11. Treatment of sporadic inclusion body myositis with bimagrumab

    PubMed Central

    Amato, Anthony A.; Sivakumar, Kumaraswamy; Goyal, Namita; David, William S.; Salajegheh, Mohammad; Praestgaard, Jens; Lach-Trifilieff, Estelle; Trendelenburg, Anne-Ulrike; Laurent, Didier; Glass, David J.; Roubenoff, Ronenn

    2014-01-01

    Objective: To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial. Methods: We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with sIBM). We tested inhibition of activin receptors IIA and IIB (ActRII) in 14 patients with sIBM using one dose of bimagrumab (n = 11) or placebo (n = 3). The primary outcome was the change in right thigh muscle volume by MRI at 8 weeks. Lean body mass, strength, and function were secondary outcomes. Twelve of the patients (10 bimagrumab, 2 placebo) participated in a subsequent 16-week observation phase. Results: Muscle SMAD2/3 phosphorylation was higher in sIBM than in other muscle diseases studied (p = 0.003). Eight weeks after dosing, the bimagrumab-treated patients increased thigh muscle volume (right leg +6.5% compared with placebo, p = 0.024; left leg +7.6%, p = 0.009) and lean body mass (+5.7% compared with placebo, p = 0.014). Subsequently, bimagrumab-treated patients had improved 6-minute walking distance, which peaked at 16 weeks (+14.6%, p = 0.008) compared with placebo. There were no serious adverse events; the main adverse events with bimagrumab were mild acne and transient involuntary muscle contractions. Conclusions: Transforming growth factor β superfamily signaling, at least through ActRII, is implicated in the pathophysiology of sIBM. Inhibition of ActRII increased muscle mass and function in this pilot trial, offering a potential novel treatment of sIBM. Classification of evidence: This study provides Class I evidence that for patients with inclusion body myositis, bimagrumab increases thigh muscle volume at 8 weeks. PMID:25381300

  12. Schuler Period in LEO Satellites

    NASA Technical Reports Server (NTRS)

    Carpenter, Russell J.; Bar-Itzhack, Itzhack Y.

    2004-01-01

    This paper generalizes and extends the concept of the Schuler oscillation that occurs in the theory of inertial navigation systems, allowing one to see how the Schuler phenomenon affects inertial navigation systems operating in space. We show why a low earth orbit satellite's orbital period is identical to the period of the Schuler pendulum, which is the period of the errors for terrestrial inertial navigation systems. We also show that the generalized form of the Schuler oscillation takes the same form as the Hill-Clohessy-Wiltshire equations for satellite relative motion and that the period of the out-of-plane motion in neighboring satellite relative trajectories is the same as the Schuler period. Finally, we describe how INS gyro drift manifests itself in different coordinate systems for the orbital case. These results may assist orbital flight dynamics and attitude control systems engineers in the design and analysis of INS-equipped spacecraft

  13. LYRA Mid-Term Periodicities

    NASA Astrophysics Data System (ADS)

    Wauters, L.; Dominique, M.; Dammasch, I. E.

    2016-08-01

    The spectra of the PROBA2/LYRA data, similarly to every other solar time series, show predominant periodicities that can be of solar or instrumental origin. In this article, we compare the main periodicities characterizing the LYRA spectrum to those found in the sunspot number, in the 10.7 cm flux, in an X-ray flare index, and in the sunspot area evolution. We focused on the 2010 to 2014 time range, for which the LYRA data are available, although we also briefly address the evolution of the main periodicities in the longer range. The mid-term periodicities at {˜} 28, {˜} 44, {˜} 54, {˜} 59, {˜} 100, {˜} 110, and {˜} 150 days appear as highly significant in several analyzed datasets. The consistency of distinct periodicities between datasets provides characteristics for the global Sun. This consistency also strengthens the reliability of LYRA data.

  14. Incorporating Spectra Into Periodic Timing

    NASA Astrophysics Data System (ADS)

    Connors, Alanna; Hong, J.; Protopapas, P.; Kashyap, V.

    2011-09-01

    The Chandra surveys have resulted in a wealth of data on low-luminosity X-ray sources (Lx 1030-34 erg/s) of Galactic scales beyond the local solar neighborhood. Many of these are compact binaries, in particular, cataclysmic variables, often identified by their periodic X-ray variability and spectra. Hong et al. (2009, 2011) have used energy quantiles (Hong, Schlegel & Grindlay, 2004) as a fast, robust indicator of spectral hardness and absorption of the X-ray sources. Energy quantiles also enable a simple but effective illustration of spectral changes with phase in these periodic systems: e.g. absorption by the accreting material is understood to drive the periodic light-curves. An interesting question is how to best make use of the information encapsulated in the periodic change in energy spectrum, along with the periodic change in intensity, especially for cases of ambiguous period determination? And, how to do it computationally efficiently? A first approach is to do the period search in intensity, as is standard; and then use a criterion of spectral variation to verify possible periods. Huijse, Zegers & Protopapas (2011) recently demonstrated a powerful period estimation technique using information potential and correntropy embedded in the light curve. Similar quantities based on energies (or energy quantiles) of X-ray photons can serve as criteria of spectral variation. A different approach treats the spectrum variations and intensity variations completely independently, searching through period-space in each, and then combining the results. A more general method would include both at the same time, looking for statistically significant variations above what is expected for a constant (in intensity and spectrum).

  15. Periodic and Quasi-Periodic Orbitsfor the Standard Map

    NASA Astrophysics Data System (ADS)

    Berretti, Alberto; Gentile, Guido

    We consider both periodic and quasi-periodic solutions for the standard map, and we study the corresponding conjugating functions, i.e. the functions conjugating the motions to trivial rotations. We compare the invariant curves with rotation numbers ω satisfying the Bryuno condition and the sequences of periodic orbits with rotation numbers given by their convergents ωN = pN/qN. We prove the following results for N--> ∞: (1) for rotation numbers ωNN we study the radius of convergence of the conjugating functions and we find lower bounds on them, which tend to a limit which is a lower bound on the corresponding quantity for ω (2) the periodic orbits consist of points which are more and more close to the invariant curve with rotation number ω (3) such orbits lie on analytical curves which tend uniformly to the invariant curve.

  16. Periodic fevers and autoinflammatory syndromes in childhood.

    PubMed

    Ostring, Genevieve T; Singh-Grewal, Davinder

    2016-09-01

    Recurrent fever is a common presentation in paediatric practice and can be caused by a wide variety of diseases including autoinflammatory conditions. The innate immune system plays an essential role in the 'first line' response to infection through mediation of inflammatory responses. Inflammasomes are part of the regulatory process for this system and result in the production of the powerful pro-inflammatory cytokine interleukin-1B. Dysregulation of inflammasomes, and Interleukin 1 production, contributes to the pathogenesis of autoinflammatory diseases. This review focuses on described periodic fever syndromes (PFS) which are now collectively referred to as autoinflammatory syndromes. Conditions discussed include periodic fever aphthous stomatitis pharyngitis and cervical adenopathy, familial Mediterranean fever, tumour necrosis factor receptor-associated periodic syndromes, hyperimmunoglobulinaemia D and the cryopyrin-associated periodic syndromes. Presenting features, complications, diagnostic and treatment approaches for these conditions are discussed. Nonetheless, as most of these conditions are rare and may have significant long-term complications, it is recommended that they be managed in consultations with a physician experienced in managing PFS. PMID:27650143

  17. Cyclical Period Changes in Short-Period Dwarf Novae

    NASA Astrophysics Data System (ADS)

    Baptista, R.; Borges, B. W.; Bond, H. E.; Jablonski, F.; Steiner, J. E.; Grauer, A. D.

    2004-01-01

    The observed-minus-calculated (O-C) diagrams of the eclipse timings of three dwarf novae of the SU UMa sub-class are presented and discussed. The (O-C) diagrams cover 28 24 and 15 years respectively for Z~Cha V2051~Oph and V4140~Sgr and show clear orbital period changes. Z~Cha shows conspicuous cyclical changes of period 28+/-2 yr and amplitude 60+/-12 s. V2051~Oph shows a cyclical period change of period 22+/-2 yr and amplitude 17+/-3 s. The (O-C) diagram of V4140~Sgr shows less convincing evidence but can also be explained in terms of a cyclical period modulation with an amplitude of about 16s and a time scale of 6.9+/-0.3 years. The best explanation for these observations is that of a solar-type magnetic activity cycle in the secondary star modulating its radius and consequently the mass transfer rate and the orbital separation on time scales of years. These results support the recent findings of Ak Ozkan & Mattei that the quiescent magnitudes and outburst interval of a sample of dwarf novae (including many SU UMa stars) show cyclical variations produced by solar-type magnetic activity cycles. Our results also confirm that the fully-convective secondary stars of these short period binaries still possess non-negligible magnetic fields.

  18. 75 FR 65593 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... Rules Concerning Periodic Reporting of Service Performance Measurements and Customer Satisfaction, May... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION... waiver request. SUMMARY: The Commission is establishing a docket to address a recent Postal...

  19. 76 FR 80312 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    .... SUMMARY: The Commission is establishing a docket to consider new measurement of Flats Sequencing Systems... of the Business Reply Mail cost model in periodic reporting of service performance measurement...). Proposal Sixteen: proposed productivity measurement for Flats Sequencing System. Proposal...

  20. Paroxysmal hypertension and spontaneous periodic hypothermia.

    PubMed

    De Plaen, J L; Sepulchre, D; Bidingija, M

    1992-01-01

    We report the case of a 42-year-old Zairian male who presented with paroxysmal attacks of hypertension accompanied by spontaneous recurrent hypothermia and profuse sweating of unknown origin. Routine and extensive examination failed to indicate a usual cause of arterial hypertension or for periodic hypothermia. Based on the hypothesis of an epileptic center influencing both the thermoregulatory and the vasomotor mechanisms, an anticonvulsant treatment was successfully installed. The present study makes a correlation between the present condition and certain neurologic abnormalities described in the literature. PMID:1337813

  1. Rapid Disease Progression With Delay in Treatment of Non-Small-Cell Lung Cancer

    SciTech Connect

    Mohammed, Nasiruddin; Kestin, Larry Llyn; Grills, Inga Siiner; Battu, Madhu; Fitch, Dwight Lamar; Wong, Ching-yee Oliver; Margolis, Jeffrey Harold; Chmielewski, Gary William; Welsh, Robert James

    2011-02-01

    Purpose: To assess rate of disease progression from diagnosis to initiation of treatment for Stage I-IIIB non-small-cell lung cancer (NSCLC). Methods and Materials: Forty patients with NSCLC underwent at least two sets of computed tomography (CT) and 18-fluorodeoxyglucose positron emission tomography (PET) scans at various time intervals before treatment. Progression was defined as development of any new lymph node involvement, site of disease, or stage change. Results: Median time interval between first and second CT scans was 13.4 weeks, and between first and second PET scans was 9.0 weeks. Median initial primary maximum tumor dimension (MTD) was 3.5 cm (0.6-8.5 cm) with a median standardized uptake value (SUV) of 13.0 (1.7-38.5). The median MTD increased by a median of 1.0 cm (mean, 1.6 cm) between scans for a median relative MTD increase of 35% (mean, 59%). Nineteen patients (48%) progressed between scans. Rate of any progression was 13%, 31%, and 46% at 4, 8, and 16 weeks, respectively. Upstaging occurred in 3%, 13%, and 21% at these intervals. Distant metastasis became evident in 3%, 13%, and 13% after 4, 8, and 16 weeks, respectively. T and N stage were associated with progression, whereas histology, grade, sex, age, and maximum SUV were not. At 3 years, overall survival for Stage III patients with vs. without progression was 18% vs. 67%, p = 0.05. Conclusions: With NSCLC, treatment delay can lead to disease progression. Diagnosis, staging, and treatment initiation should be expedited. After 4-8 weeks of delay, complete restaging should be strongly considered.

  2. Period Adjustment of TT Scuti

    NASA Astrophysics Data System (ADS)

    Cederbloom, Steve E.

    1985-12-01

    The RR Lyrae variable TT Scuti was studied using photographic photometry. The O-C data show a possible downwards curve, which would indicate a decreasing period, but the results are not conclusive. New linear elements are: JD(max) = 2439384.915 + 0.45293855 E. A limit for the maximum rate of change of the period is -0.03 +/- 0.04 cycles per million years.

  3. Topical Treatment of Nonhealing Venous Leg Ulcer with Propolis Ointment

    PubMed Central

    Kucharzewski, M.; Kózka, M.; Urbanek, T.

    2013-01-01

    An investigation of effectiveness of topical treatment of nonhealing chronic venous leg ulcers with propolis ointment was conducted. 56 patients were included in the study and randomized into two groups. In group 1, there were 28 patients (ulceration area: 6.9–9.78 cm2) treated by means of topical propolis ointment application and short stretch bandage compression. In group 2, there were 29 patients (ulceration area: 7.2–9.4 cm2) treated by means of Unna boot leg compression without topical propolis treatment. In the study, the efficacy of both treatment methods in patients with resistive venous leg ulcers was compared. The ulceration of patients from group 1 healed completely after 6 weeks of therapy in all cases. In all patients from group 2, the process of healing was longer but successfully completed after 16 weeks of the therapy. We found that an adjunctive propolis ointment treatment increases the efficacy of the short stretch bandage compression stocking, and this combined treatment is more effective than Unna's boot compression alone. PMID:23662121

  4. Substance use in the perinatal period

    PubMed Central

    Forray, Ariadna; Foster, Dawn

    2015-01-01

    Perinatal substance use remains a major public health problem and is associated with a number of deleterious maternal and fetal effects. Polysubstance use in pregnancy is common, and can potentiate adverse maternal and fetal outcomes. Tobacco is the most commonly used substance in pregnancy, followed by alcohol and illicit substances. The treatments for perinatal substance use are limited and consist mostly of behavioral and psychosocial interventions. Of these contingency management has shown the most efficacy. More recently, novel interventions such as progesterone for postpartum cocaine use have shown promise. The purpose of this review is to examine the recent literature on the use of tobacco, alcohol, cannabis, stimulants, and opioids in the perinatal period, their effects on maternal and fetal health and current treatments. PMID:26386836

  5. Substance Use in the Perinatal Period.

    PubMed

    Forray, Ariadna; Foster, Dawn

    2015-11-01

    Perinatal substance use remains a major public health problem and is associated with a number of deleterious maternal and fetal effects. Polysubstance use in pregnancy is common and can potentiate adverse maternal and fetal outcomes. Tobacco is the most commonly used substance in pregnancy, followed by alcohol and illicit substances. The treatments for perinatal substance use are limited and consist mostly of behavioral and psychosocial interventions. Of these, contingency management has shown the most efficacy. More recently, novel interventions such as progesterone for postpartum cocaine use have shown promise. The purpose of this review is to examine the recent literature on the use of tobacco, alcohol, cannabis, stimulants, and opioids in the perinatal period, their effects on maternal and fetal health, and current treatments. PMID:26386836

  6. Shortest recurrence periods of novae

    SciTech Connect

    Kato, Mariko; Saio, Hideyuki; Hachisu, Izumi; Nomoto, Ken'ichi

    2014-10-01

    Stimulated by the recent discovery of the 1 yr recurrence period nova M31N 2008-12a, we examined the shortest recurrence periods of hydrogen shell flashes on mass-accreting white dwarfs (WDs). We discuss the mechanism that yields a finite minimum recurrence period for a given WD mass. Calculating the unstable flashes for various WD masses and mass accretion rates, we identified a shortest recurrence period of about two months for a non-rotating 1.38 M {sub ☉} WD with a mass accretion rate of 3.6 × 10{sup –7} M {sub ☉} yr{sup –1}. A 1 yr recurrence period is realized for very massive (≳ 1.3 M {sub ☉}) WDs with very high accretion rates (≳ 1.5 × 10{sup –7} M {sub ☉} yr{sup –1}). We revised our stability limit of hydrogen shell burning, which will be useful for binary evolution calculations toward Type Ia supernovae.

  7. Bragg interactions in periodic media

    NASA Technical Reports Server (NTRS)

    Jaggard, D. L.

    1976-01-01

    The interaction of electromagnetic waves of wavelength lambda with periodic structures of spatial period lambda are studied. The emphasis of the work is on Bragg interactions where lambda approximately equal to 2 lambda/N and the Bragg order N takes on the values 1, 2,.... An extended coupled waves (ECW) theory is developed for the case N greater or equal to 2 and the results of the theory are found to compare favorably with the exact results of Floquet theory. Numerous numerical results are displayed as Brillouin diagrams for the first few Bragg orders. Moreover, explicit expressions for coupling coefficients, bandgap shifts and bandgap widths are derived for singly periodic media. Particular note is taken of phase speeding effects.

  8. Periodicity in marine extinction events

    NASA Technical Reports Server (NTRS)

    Sepkoski, J. John, Jr.; Raup, David M.

    1986-01-01

    The periodicity of extinction events is examined in detail. In particular, the temporal distribution of specific, identifiable extinction events is analyzed. The nature and limitations of the data base on the global fossil record is discussed in order to establish limits of resolution in statistical analyses. Peaks in extinction intensity which appear to differ significantly from background levels are considered, and new analyses of the temporal distribution of these peaks are presented. Finally, some possible causes of periodicity and of interdependence among extinction events over the last quarter billion years of earth history are examined.

  9. Bone response to 3-D periodic hydroxyapatite scaffolds with and without tailored microporosity to deliver bone morphogenetic protein 2.

    SciTech Connect

    Eurell, Jo Ann; Dellinger, Jennifer Gwynne; Cesarano, Joseph, III; Jamison, Russell D.

    2005-06-01

    The in vivo bone response of 3D periodic hydroxyapatite (HA) scaffolds is investigated. Two groups of HA scaffolds (11 mm diameter x 3.5 mm thick) are fabricated by direct-write assembly of a concentrated HA ink. The scaffolds consist of cylindrical rods periodically arranged into four quadrants with varying separation distances between rods. In the first group, HA rods (250 {micro}m in diameter) are patterned to create pore channels, whose areal dimensions are 250 x 250 {micro}m{sup 2} in quadrant 1, 250 x 500 {micro}m{sup 2} in quadrants 2 and 4, and 500 x 500 {micro}m{sup 2} in quadrant 3. In the second group, HA rods (400 {micro}m in diameter) are patterned to create pore channels, whose areal dimensions of 500 x 500 {micro}m{sup 2} in quadrant 1, 500 x 750 {micro}m{sup 2} in quadrants 2 and 4, and 750 x 750 {micro}m{sup 2} in quadrant 3. Each group of scaffolds is partially densified by sintering at 1200 C prior to being implanted bilaterally in trephine defects of skeletally mature New Zealand White rabbits. Their tissue response is evaluated at 8 and 16 weeks using micro-computed tomography, histology, and scanning electron microscopy. New trabecular bone is conducted rapidly and efficiently across substantial distances within these patterned 3D HA scaffolds. Our observations suggest that HA rods are first coated with a layer of new bone followed by subsequent scaffold infilling via outward and inward radial growth of the coated regions. Direct-write assembly of 3D periodic scaffolds composed of micro-porous HA rods arrayed to produce macro-pores that are size-matched to trabecular bone may represent an optimal strategy for bone repair and replacement structures.

  10. Split thickness skin grafts for the treatment of non-healing foot and leg ulcers in patients with diabetes: a retrospective review

    PubMed Central

    Anderson, John J.; Wallin, Kelly J.; Spencer, Loren

    2012-01-01

    We retrospectively reviewed 107 diabetic patients who received a split thickness skin graft (STSG) for treatment of a non-healing diabetic foot or leg ulcer to describe healing times based on patient characteristics, comorbidities or complications. The minimum follow-up was 6 months from the time of STSG application. The mean time to healing among all patients was 5.1 weeks (3 to 16 weeks). The mean healing time for patients with complications was 12.0 weeks (10 to 16 weeks) while the mean healing time for those without complications was 4.9 weeks (3 to 10 weeks). Overall complication rate was 2.8%. Patients with a STSG take of less than 95% had a mean healing time of 7.9 weeks compared to 4.8 weeks for those with a STSG take of 100% (p<0.001). The use of autologous STSG for treatment of non-healing diabetic foot and leg wounds is a viable method for soft tissue closure and may present a low complication rate and a satisfactory rate of healing. PMID:22403742

  11. Split thickness skin grafts for the treatment of non-healing foot and leg ulcers in patients with diabetes: a retrospective review.

    PubMed

    Anderson, John J; Wallin, Kelly J; Spencer, Loren

    2012-01-01

    We retrospectively reviewed 107 diabetic patients who received a split thickness skin graft (STSG) for treatment of a non-healing diabetic foot or leg ulcer to describe healing times based on patient characteristics, comorbidities or complications. The minimum follow-up was 6 months from the time of STSG application. The mean time to healing among all patients was 5.1 weeks (3 to 16 weeks). The mean healing time for patients with complications was 12.0 weeks (10 to 16 weeks) while the mean healing time for those without complications was 4.9 weeks (3 to 10 weeks). Overall complication rate was 2.8%. Patients with a STSG take of less than 95% had a mean healing time of 7.9 weeks compared to 4.8 weeks for those with a STSG take of 100% (p<0.001). The use of autologous STSG for treatment of non-healing diabetic foot and leg wounds is a viable method for soft tissue closure and may present a low complication rate and a satisfactory rate of healing. PMID:22403742

  12. Rotational Period of 2770 Tsvet

    NASA Astrophysics Data System (ADS)

    Franco, Lorenzo; Papini, Riccardo

    2014-07-01

    Photometric observations of main-belt asteroid 2770 Tsvet were made over three nights during 2014 March. Lightcurve analysis shows a synodic period P = 7.82 ± 0.01 h with an amplitude A = 0.47 ± 0.03 mag.

  13. 76 FR 8325 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... Service Performance Measurements and Customer Satisfaction, May 25, 2010, at 22-24 (Order No. 465). Order... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION... certain temporary waivers from periodic reporting of service performance measurement. Establishing...

  14. On Some Periodic Toda Lattices

    PubMed Central

    Kac, M.; Van Moerbeke, Pierre

    1975-01-01

    A discrete version of Floquet's theory is developed and applied to a system of non-linear differential equations related to the periodic Toda lattice. A special solution previously found by Toda is thus seen to fit into the formalism of inverse scattering problems. PMID:16592244

  15. Shell Games: Uncovering Periodic Properties.

    ERIC Educational Resources Information Center

    Lamb, William G.

    1983-01-01

    Describes activities (demonstrations/experiments) used to introduce history of periodic properties--without electrons, orbitals, filling shells, or any conception of atoms beyond Dalton's model. Activities supplement first chapter in a currently available chemistry text. Indicates potential danger of experiments if proper safety precautions are…

  16. The Period of Salutary Neglect.

    ERIC Educational Resources Information Center

    Hyland, John T.; And Others

    1987-01-01

    Presents a lesson designed to teach students about the period of Salutary Neglect (100 years before the French and Indian Wars) and its effects on later historical events. Provides an advance organizer which puts students in a situation of salutary neglect and includes student and teacher resources on the Stamp Act, the Townshend Acts, and the…

  17. Quantifying periodicity in omics data.

    PubMed

    Amariei, Cornelia; Tomita, Masaru; Murray, Douglas B

    2014-01-01

    Oscillations play a significant role in biological systems, with many examples in the fast, ultradian, circadian, circalunar, and yearly time domains. However, determining periodicity in such data can be problematic. There are a number of computational methods to identify the periodic components in large datasets, such as signal-to-noise based Fourier decomposition, Fisher's g-test and autocorrelation. However, the available methods assume a sinusoidal model and do not attempt to quantify the waveform shape and the presence of multiple periodicities, which provide vital clues in determining the underlying dynamics. Here, we developed a Fourier based measure that generates a de-noised waveform from multiple significant frequencies. This waveform is then correlated with the raw data from the respiratory oscillation found in yeast, to provide oscillation statistics including waveform metrics and multi-periods. The method is compared and contrasted to commonly used statistics. Moreover, we show the utility of the program in the analysis of noisy datasets and other high-throughput analyses, such as metabolomics and flow cytometry, respectively.

  18. 76 FR 20906 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... a proposed change in certain analytical methods used in periodic reporting. This action responds to... an informal rulemaking proceeding to consider changes in the analytical methods approved for use in... Proceeding to Consider Proposed Changes in Analytic Principles (Proposal One), April 6, 2011...

  19. Model-based treatment optimization of a novel VEGFR inhibitor

    PubMed Central

    Keizer, Ron J.; Gupta, Anubha; Shumaker, Robert; Beijnen, Jos H.; Schellens, Jan H. M.; Huitema, Alwin D. R.

    2012-01-01

    AIM To evaluate dosing and intervention strategies for the phase II programme of a VEGF receptor inhibitor using PK–PD modelling and simulation, with the aim of maximizing (i) the number of patients on treatment and (ii) the average dose level during treatment. METHODS A previously developed PK–PD model for lenvatinib (E7080) was updated and parameters were re-estimated (141 patients, once daily and twice daily regimens). Treatment of lenvatinib was simulated for 16 weeks, initiated at 25 mg once daily. Outcome measures included the number of patients on treatment and overall drug exposure. A hypertension intervention design proposed for phase II studies was evaluated, including antihypertensive treatment and dose de-escalation. Additionally, a within-patient dose escalation was investigated, titrating up to 50 mg once daily unless unacceptable toxicity occurred. RESULTS Using the proposed antihypertension intervention design, 82% of patients could remain on treatment, and the mean dose administered was 21.5 mg day−1. The adverse event (AE) guided dose titration increased the average dose by 4.6 mg day−1, while only marginally increasing the percentage of patients dropping out due to toxicity (from 18% to 20.8%). CONCLUSIONS The proposed hypertension intervention design is expected to be effective in maintaining patients on treatment with lenvatinib. The AE-guided dose titration with blood pressure as a biomarker yielded a higher overall dose level, without relevant increases in toxicity. Since increased exposure to lenvatinib seems correlated with increased treatment efficacy, the adaptive treatment design may thus be a valid approach to improve treatment outcome. PMID:22295876

  20. Incontinence Treatment: Surgical Treatments

    MedlinePlus

    ... Incontinence Managing Incontinence: A Survey The Patient's Perspective Barriers on Diagnosis and Treatment Personal Stories Contact Us ... Incontinence Managing Incontinence: A Survey The Patient's Perspective Barriers on Diagnosis and Treatment Personal Stories Contact Us ...

  1. Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder.

    PubMed

    Venkataraman, Archana; Yang, Daniel Y-J; Dvornek, Nicha; Staib, Lawrence H; Duncan, James S; Pelphrey, Kevin A; Ventola, Pamela

    2016-09-28

    Behavioral interventions for autism have gained prominence in recent years; however, the neural-systems-level targets of these interventions remain poorly understood. We use a novel Bayesian framework to extract network-based differences before and after a 16-week pivotal response treatment (PRT) regimen. Our results suggest that the functional changes induced by PRT localize to the posterior cingulate and are marked by a shift in connectivity from the orbitofrontal cortex to the occipital-temporal cortex. Our results illuminate a potential PRT-induced learning mechanism, whereby the neural circuits involved during social perception shift from sensory and attentional systems to higher-level object and face processing areas. PMID:27532879

  2. Surgical Treatment for Unstable Distal Clavicle Fracture with Micromovable and Anatomical Acromioclavicular Plate

    PubMed Central

    Liu, Qingjun; Miao, Jianyun; Lin, Bin; Lian, Kejian

    2012-01-01

    Between 2006 and 2009, 18 patients of distal clavicle fracture were treated with micro-movable and anatomical acromioclavicular plate (MAAP) in our department. According to the Neer's classification, all cases were unstable with type IIA (12 cases) and type IIB (6 cases). Functional outcome was evaluated using the Karlsson's criteria. The mean follow-up was 18 months (range, 12-36months). No postoperative plate screws complication was observed. Osseous union could be achieved at a mean time of 12 weeks after operation in 18 patients (range, 8 -16 weeks). According to Karlsson's criteria, radiographic appearances and postoperative shoulder functional recovery revealed a good and excellent rate in these cases. We conclude that surgical treatment using MAAP seems to be a good option for unstable type II fractures of the distal clavicle. This technique allows for reliable fixation with early functional exercises and functional recovery. PMID:22701337

  3. Surgical treatment for unstable distal clavicle fracture with micromovable and anatomical acromioclavicular plate.

    PubMed

    Liu, Qingjun; Miao, Jianyun; Lin, Bin; Lian, Kejian

    2012-01-01

    Between 2006 and 2009, 18 patients of distal clavicle fracture were treated with micro-movable and anatomical acromioclavicular plate (MAAP) in our department. According to the Neer's classification, all cases were unstable with type IIA (12 cases) and type IIB (6 cases). Functional outcome was evaluated using the Karlsson's criteria. The mean follow-up was 18 months (range, 12-36months). No postoperative plate screws complication was observed. Osseous union could be achieved at a mean time of 12 weeks after operation in 18 patients (range, 8 -16 weeks). According to Karlsson's criteria, radiographic appearances and postoperative shoulder functional recovery revealed a good and excellent rate in these cases. We conclude that surgical treatment using MAAP seems to be a good option for unstable type II fractures of the distal clavicle. This technique allows for reliable fixation with early functional exercises and functional recovery.

  4. Quantum gates by periodic driving

    PubMed Central

    Shi, Z. C.; Wang, W.; Yi, X. X.

    2016-01-01

    Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions—it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation. PMID:26911900

  5. Periodic Structures in Optical Fibres.

    NASA Astrophysics Data System (ADS)

    Hand, Duncan Paul

    1990-01-01

    Available from UMI in association with The British Library. The work presented in this thesis concerns techniques for the formation of periodic structures in optical fibres. Two different methods of producing such structures are studied in detail. The first of these involves a breakdown mechanism (known as the 'fibre fuse') that permanently damages the core glass in a periodic manner leaving it unable to guide light. The dynamics of this mechanism are studied, with a view to controlling it for the production of interactive grating structures. It is determined that, due to a sharp rise in fibre absorption with temperature, a thermal shock -wave, with a typical thermal gradient of several hundred degrees Kelvin per micron, forms and travels along the fibre, heating the core glass to such an extent that damage occurs. The periodicity of the resultant damage arises from thermal focusing and defocusing of light in the region of this shock-wave. The second method makes use of the photorefractivity observed in certain germanosilicate fibres on exposure to moderate intensity blue light of wavelength ~480nm or UV light ~240nm. A single-mode fibre transmission filter is demonstrated for the first time, produced by exposing a fibre Sagnac loop mirror to 488nm holographic fringes. Average index changes are shown to occur if such fibres are exposed to spatially uniform blue or UV light, indicating that grating formation is by a different mechanism to the local charge separation which occurs in photorefractive crystals. The various characteristics of these average index changes are measured and analysed, with the conclusion that they result from defect centre formation, driven by two photon absorption with blue light, or single photon absorption with UV light. Associated birefringence changes are also measured and are exploited in a hi-bi fibre to periodically perturb the birefringence axes, producing a narrow-line transmission filter.

  6. Down hole periodic seismic generator

    DOEpatents

    Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

    1989-01-01

    A down hole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

  7. Advanced downhole periodic seismic generator

    DOEpatents

    Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

    1991-07-16

    An advanced downhole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

  8. A Pilot SMART for Developing an Adaptive Treatment Strategy for Adolescent Depression.

    PubMed

    Gunlicks-Stoessel, Meredith; Mufson, Laura; Westervelt, Ana; Almirall, Daniel; Murphy, Susan

    2016-01-01

    This pilot study was conducted to assess the feasibility and acceptability of 4 adaptive treatment strategies (ATSs) for adolescent depression to plan for a subsequent full-scale clinical trial. The ATSs aim to address 2 questions that arise when personalizing treatment: (a) For adolescents treated with Interpersonal Psychotherapy for depressed adolescents (IPT-A; Mufson et al., 2004 ), at what time point should therapists make the determination that the adolescent is not likely to respond if the initial treatment plan is continued (week 4 or week 8)? (b) For adolescents who are judged to need their treatment augmented, should the therapist increase the number of IPT-A sessions or add pharmacotherapy (fluoxetine)? A 16-week pilot sequential multiple assignment randomized trial (SMART) was conducted with 32 adolescents (M age = 14.9) who had a diagnosis of major depressive disorder, dysthymic disorder, or depressive disorder not otherwise specified. Adolescents were primarily female (75%) and Caucasian (84.4%). Data regarding the feasibility and acceptability of the study and treatment procedures and treatment response rates were collected. Week 4 was the more feasible and acceptable decision point for assessing need for a change to treatment. Adolescents, parents, and therapists reported a range of attitudes about medication and more intensive therapy as treatment options. Results from the pilot study have yielded additional research questions for the full-scale SMART and will improve our ability to successfully conduct the trial.

  9. Haemocytic periodicity and periodic disorders: Periodic neutropenia, thrombocytopenia, lymphocytosis and anaemia

    PubMed Central

    Reimann, Hobart A.

    1971-01-01

    Evidence has accumulated of rhythmic numerical oscillation of each of the blood cells either independently or in combinations. The cyclic changes originate in the marrow of some normal persons and animals without causing illness, and can be induced experimentally. In more than 100 reported instances, periodic oscillations of various cells were accompanied by respective episodes of the disorders named in the title. The disorders may be transitory but usually recur throughout life and occasionally are fatal. All resist therapy. Features in common suggest an interrelationship of the haemal disorders and other disparate heritable periodic diseases. Theoretically, the rhythms are regulated by ubiquitous, inherent, intracellular bioclocks controlled hypothalamically or neurohumorally in relation to a feedback mechanism. Reactions to long cycles are of greater clinical importance than disturbances arising from the circadian rhythm. PMID:4397784

  10. Rotational period of GQ Lupi

    NASA Astrophysics Data System (ADS)

    Broeg, C.; Schmidt, T. O. B.; Guenther, E.; Gaedke, A.; Bedalov, A.; Neuhäuser, R.; Walter, F. M.

    2007-06-01

    Aims: We wanted to determine the rotation parameters of GQ Lup A, thereby constraining the evolutionary history of the GQ Lup system. Methods: We have undertaken a photometric monitoring campaign on GQ Lup A consisting of two epochs spaced one year apart. We also searched the photometric archives to enlarge the data set. Results: We were able to determine the photometric period (8.45±0.2 days) in both epochs in several photometric bands. This periodicity could also be found in some of the archival data. The combined false-alarm probability is 0.015. The variation is most likely caused by hot spots on the surface of GQ Lup A. This, combined with high-resolution spectra (v sin i) allows calculation of GQ Lup A's inclination (i=27±5°). Radial velocity data also contains this period but is inconclusive. Nevertheless, the RV data supports the interpretation that hot spots cause the photometric variation. We use the known K-band variability, amplitude, and phase of GQ Lup A together with a new image of GQ Lup A+b, taken quasi-simultaneously with our monitoring of the star, to confirm the magnitude and, hence, luminosity of the companion. Based on observations obtained on Cerro Paranal, Chile, in ESO program 075.C-0710(C) and on La Silla, Chile, in ESO programs 074.C-0034(A),075.C-0710(E), 075.C-0710(F), 075.C-0202(A), 076.C-0010(A) as well as with ANDICAM of the SMARTS consortium. Photometry data of epochs I and II are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/468/1039

  11. Periodic roads and quantized wheels

    NASA Astrophysics Data System (ADS)

    de Campos Valadares, Eduardo

    2016-08-01

    We propose a simple approach to determine all possible wheels that can roll smoothly without slipping on a periodic roadbed, while maintaining the center of mass at a fixed height. We also address the inverse problem that of obtaining the roadbed profile compatible with a specific wheel and all other related "quantized wheels." The role of symmetry is highlighted, which might preclude the center of mass from remaining at a fixed height. A straightforward consequence of such geometric quantization is that the gravitational potential energy and the moment of inertia are discrete, suggesting a parallelism between macroscopic wheels and nano-systems, such as carbon nanotubes.

  12. Periodic permanent magnet focused klystron

    SciTech Connect

    Ferguson, Patrick; Read, Michael; Ives, R Lawrence

    2015-04-21

    A periodic permanent magnet (PPM) klystron has beam transport structures and RF cavity structures, each of which has permanent magnets placed substantially equidistant from a beam tunnel formed about the central axis, and which are also outside the extent of a cooling chamber. The RF cavity sections also have permanent magnets which are placed substantially equidistant from the beam tunnel, but which include an RF cavity coupling to the beam tunnel for enhancement of RF carried by an electron beam in the beam tunnel.

  13. Treatment of Late-Life Depression Alleviates Caregiver Burden

    PubMed Central

    Martire, Lynn M.; Schulz, Richard; Reynolds, Charles F.; Karp, Jordan F.; Gildengers, Ariel G.; Whyte, Ellen M.

    2010-01-01

    Objectives To describe the burden experienced by family caregivers of older adults with depression and to examine the positive effects on caregivers of treating late-life depression. Design Two-phase treatment study for major depressive disorder (MDD) that included 6 weeks of open treatment with antidepressant medication for all older patients followed by 16 weeks of randomized treatment for patients who were partial responders, comparing a combination of medication and interpersonal psychotherapy with medication alone. Setting Primary care and university late-life mental health research clinic. Participants Adults aged 60 and older participating in a randomized trial for treatment of MDD who enrolled in a family caregiver study and their caregiver (N = 244 dyads). Measurements Improvement in patient symptoms during open treatment (lower scores on the Hamilton Rating Scale for Depression (HRSD)) and remission of depression during randomized treatment (3 consecutive weekly HRSD scores of ≤7) were examined as predictors of lower general caregiver burden and burden specific to patient depression. Results Caregivers reported a moderate to high level of general caregiver burden on average. Change in patient depression during open treatment was associated with significantly decreased depression-specific burden (β = −0.22, P =.001) and a trend toward lower general burden (β = − 0.08, P =.08). Caregivers of patients who remitted showed significantly decreased depression-specific burden (F (1,76) = 4.27, P =.04). Conclusion Treatment of late-life depression has benefits that extend to the family members on whom patients depend. Caregiver education and support may strengthen these effects. PMID:19943833

  14. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  15. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  16. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  17. 7 CFR 930.7 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Definitions § 930.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period beginning on July 1 of any year and ending on June 30 of the following year, or such other period as the... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal period. 930.7 Section 930.7...

  18. Periodic bedrock ridges on Mars

    NASA Astrophysics Data System (ADS)

    Montgomery, David R.; Bandfield, Joshua L.; Becker, Scott K.

    2012-03-01

    Evidence for sediment transport and erosion by wind is widespread over the surface of Mars today and was likely a major geomorphic process for much of its geological past. Although Martian surface features resembling aeolian dunes and ripples have been recognized since the Mariner and Viking missions, such features have been interpreted previously as active, indurated, or exhumed sedimentary forms. Here we report evidence based on High Resolution Imaging Science Experiment images that show some megaripple forms are eroded into cohesive substrate rather than being composed of loose granular material or fossilized dunes. Exposure of stratigraphic continuity within layered, cohesive material extending crest to trough through features with mean wavelengths of 18 to 51 m demonstrates the primarily erosional formation of what we term periodic bedrock ridges (PBRs). Hence some surfaces on Mars previously considered to be covered by wind-deposited material are actually wind-carved exposures that offer windows into Martian history. PBRs lack the distinctive streamlining associated with wind-parallel yardangs and comparison of PBR orientation to yardangs, megayardangs, and active sedimentary dunes in the same vicinity confirm that these PBRs formed transverse to prevailing winds. Observed wavelengths of PBRs are comparable to those predicted by a simple model for erosional wavelengths of periodic transverse bed forms owing to the spacing of flow separations within the flow. Recognition of these transverse aeolian erosional forms brings up the question of how widespread Martian PBRs are and how many have been misinterpreted as active or indurated (fossilized) sedimentary dunes.

  19. Quasi-periodic spatiotemporal filtering.

    PubMed

    Burghouts, Gertjan J; Geusebroek, Jan-Mark

    2006-06-01

    This paper presents the online estimation of temporal frequency to simultaneously detect and identify the quasiperiodic motion of an object. We introduce color to increase discriminative power of a reoccurring object and to provide robustness to appearance changes due to illumination changes. Spatial contextual information is incorporated by considering the object motion at different scales. We combined spatiospectral Gaussian filters and a temporal reparameterized Gabor filter to construct the online temporal frequency filter. We demonstrate the online filter to respond faster and decay faster than offline Gabor filters. Further, we show the online filter to be more selective to the tuned frequency than Gabor filters. We contribute to temporal frequency analysis in that we both identify ("what") and detect ("when") the frequency. In color video, we demonstrate the filter to detect and identify the periodicity of natural motion. The velocity of moving gratings is determined in a real world example. We consider periodic and quasiperiodic motion of both stationary and nonstationary objects. PMID:16764282

  20. Permeability relation for periodic structures.

    PubMed

    Dunn, K J; LaTorraca, G A; Bergman, D J

    1998-01-01

    The permeability relation for periodic porous media is studied with respect to other petrophysical parameters such as formation factor, porosity, surface-to-volume ratio, and nuclear magnetic resonance (NMR) relaxation time. All these quantities were computed for periodic structures of simple, body-centered, and face-centered cubic arrays of touching and overlapping spheres. The formation factors were calculated by using a method which is based on a Fourier-space representation of an integral equation for the electric potential in a two-component composite. The nuclear magnetic resonance relaxation time for the case where surface-enchanced relaxation plays a dominant role is known to be V P/rho S (VP is the pore volume, S is the pore surface, is the surface relaxation strength) when rho is not too large. Previously calculated permeabilities for these structures from the literature were used for correlation studies with other petrophysical parameters. Various correlation schemes among these quantities, such as k = aTbFc, and k = aTb phi c, were investigated, where k is permeability, T is the NMR relaxation time, phi is the porosity, and F is the formation factor. PMID:9803908

  1. Treatment of sex offenders with Depo-Provera.

    PubMed

    Kiersch, T A

    1990-01-01

    Medroxyprogesterone acetate (MPA) is capable of reducing male testosterone blood levels with a corresponding reduction in sexual interest and activity. An attempt to evaluate its effectiveness with court committed sexual offenders was made with eight subjects each serving as his own control by alternating Depo-Provera injections for 16 weeks with saline injections for a corresponding 16 weeks. This paper reports the results of this study and the conclusions that appear to be appropriate.

  2. 40 CFR 35.910-2 - Period of availability; reallotment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Period of availability; reallotment. 35.910-2 Section 35.910-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water...

  3. 40 CFR 35.910-2 - Period of availability; reallotment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Period of availability; reallotment. 35.910-2 Section 35.910-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water...

  4. 40 CFR 35.910-2 - Period of availability; reallotment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Period of availability; reallotment. 35.910-2 Section 35.910-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water...

  5. 40 CFR 35.910-2 - Period of availability; reallotment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Period of availability; reallotment. 35.910-2 Section 35.910-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water...

  6. [Pregnancy and lactation period: Which local anesthetics and analgesics?].

    PubMed

    Fatori Popovic, Sandra; Lübbers, Heinz-Theo; von Mandach, Ursula

    2016-01-01

    The aim of this paper is to show relevant aspects of dental treatment in pregnancy. Common medication used in dental offices should be highlighted in special regard to the pregnant patient during dental treatment. The reader should gain more security in the election of the proper drugs for local anesthesia and oral analgesics. Local anaesthetics such as articain with adrenalin in a dilution of 1 : 200 000 can be used for dental treatment at any time. Paracetamol should be used as first line oral analgesic. Elective dental procedures should be postponed after delivery and after lactation period. PMID:27142442

  7. Periodic folding of viscous sheets

    NASA Astrophysics Data System (ADS)

    Ribe, Neil M.

    2003-09-01

    The periodic folding of a sheet of viscous fluid falling upon a rigid surface is a common fluid mechanical instability that occurs in contexts ranging from food processing to geophysics. Asymptotic thin-layer equations for the combined stretching-bending deformation of a two-dimensional sheet are solved numerically to determine the folding frequency as a function of the sheet’s initial thickness, the pouring speed, the height of fall, and the fluid properties. As the buoyancy increases, the system bifurcates from “forced” folding driven kinematically by fluid extrusion to “free” folding in which viscous resistance to bending is balanced by buoyancy. The systematics of the numerically predicted folding frequency are in good agreement with laboratory experiments.

  8. Spontaneous periodic hypothermia and hyperhidrosis.

    PubMed

    Dundar, Nihal Olgac; Boz, Adil; Duman, Ozgur; Aydin, Funda; Haspolat, Senay

    2008-12-01

    We present a patient diagnosed with Shapiro syndrome without corpus callosum agenesis. A 4-year-old-girl was admitted to the hospital with complaints of sweating, cooling, and drowsiness that continued during the last week of her admission. Attacks occurred almost daily, and lasted for about 1 hour. All laboratory findings, as well as Holter and echocardiography results, were normal. Cranial magnetic resonance imaging demonstrated an intact corpus callosum, and electroencephalography obtained during an attack revealed normal findings. However, technetium 99m-labeled hexamethylpropylene amine oxime brain single-photon emission computed tomography indicated increased perfusion in the right thalamus, basal ganglia, and inferior frontal areas during a hypothermic period. Although oxcarbazepine reduced the frequency of attacks, they were not halted completely. The patient responded better to carbamazepine. PMID:19027594

  9. An open-label Phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay-Sachs or Sandhoff variants).

    PubMed

    Clarke, Joe T R; Mahuran, Don J; Sathe, Swati; Kolodny, Edwin H; Rigat, Brigitte A; Raiman, Julian A; Tropak, Michael B

    2011-01-01

    Late-onset GM2 gangliosidosis is an autosomal recessive, neurodegenerative, lysosomal storage disease, caused by deficiency of ß-hexosaminidase A (Hex A), resulting from mutations in the HEXA (Tay-Sachs variant) or the HEXB (Sandhoff variant) genes. The enzyme deficiency in many patients with juvenile or adult onset forms of the disease results from the production of an unstable protein, which becomes targeted for premature degradation by the quality control system of the smooth endoplasmic reticulum and is not transported to lysosomes. In vitro studies have shown that many mutations in either the α or β subunit of Hex A can be partially rescued, i.e. enhanced levels of both enzyme protein and activity in lysosomes, following the growth of patient cells in the presence of the drug, pyrimethamine. The objectives of the present clinical trial were to establish the tolerability and efficacy of the treatment of late-onset GM2 gangliosidosis patients with escalating doses of pyrimethamine, to a maximum of 100 mg per day, administered orally in a single daily dose, over a 16-week period . The primary objective, tolerability, was assessed by regular clinical examinations, along with a panel of hematologic and biochemical studies. Although clinical efficacy could not be assessed in this short trial, treatment efficacy was evaluated by repeated measurements of leukocyte Hex A activity, expressed relative to the activity of lysosomal ß-glucuronidase. A total of 11 patients were enrolled, 8 males and 3 females, aged 23 to 50 years. One subject failed the initial screen, another was omitted from analysis because of the large number of protocol violations, and a third was withdrawn very early as a result of adverse events which were not drug-related. For the remaining 8 subjects, up to a 4-fold enhancement of Hex A activity at doses of 50 mg per day or less was observed. Additionally marked individual variations in the pharmacokinetics of the drug among the patients were

  10. A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs.

    PubMed

    Steffan, Jean; Favrot, Claude; Mueller, Ralf

    2006-02-01

    The efficacy of cyclosporin A (CsA) for the treatment of canine atopic dermatitis was evaluated based on the systematic review of prospective clinical trials published between 2001 and 2005. Ten studies with adequate design characteristics were included. These studies enrolled 799 dogs, 672 (84%) treated with CsA, 160 (20%) with placebo, 74 (9%) with oral glucocorticoids and 23 (3%) with antihistamines. Treatment duration varied from 2 weeks to 6 months. For safety analysis, data were available from 660 dogs. Lesion scores were improved from baseline in the range of 30-52%, 53-84% and 52-69% after 4, 6 and 16 weeks, respectively. The percentage of dogs with only mild pruritus rose from 0-13% at inclusion to 32-59% and 46-90% after 4 and 12 weeks, respectively. In most studies, the frequency of CsA administration could be reduced to every other day in 40% to 50% of patients after 4 weeks and to twice weekly in 20-26% of the dogs after 12-16 weeks. Meta-analysis confirmed highly significant effects of CsA compared to placebo, but none between oral CsA and glucocorticoids. The initial disease severity, age or body weight of subjects did not influence treatment success. Improvement by more than 50% over baseline of lesion scores was predictive of a better response during treatment maintenance. Vomiting and soft stools/diarrhoea were the most frequent adverse events seen at least once during the studies. These occurred in 25% and 15% of subjects, respectively. The frequency of each other type of adverse events was lower than 2.1%. In summary, the administration of CsA for the treatment of canine AD was found to be as effective as that of glucocorticoids, and adverse effects were minimal.

  11. Risedronate, a highly effective oral agent in the treatment of patients with severe Paget's disease.

    PubMed

    Singer, F R; Clemens, T L; Eusebio, R A; Bekker, P J

    1998-06-01

    Thirteen patients with severe Paget's disease of bone [mean serum alkaline phosphatase (SAP) level 17 times the upper limit of normal] were treated with 30 mg oral risedronate daily for 8 weeks. Patients were followed for 16 weeks without treatment. The change from baseline SAP was the primary end point. Those patients whose SAP levels did not reach the normal range were retreated with 30 mg for another 8 weeks. There was a mean percent decrease in SAP of 77% after the first course of risedronate treatment and 87% after the second course of treatment. All patients who completed the study had a decrease in SAP of at least 77% from the baseline. The urinary hydroxyproline/creatinine level was decreased by 64% and 79%, respectively, during the first and second treatment courses. There were transient asymptomatic decreases in serum calcium and phosphorus levels. The urinary calcium/creatinine ratio also decreased in these patients. Serum intact PTH and 1,25-dihydroxyvitamin D levels increased transiently during risedronate treatment. Oral risedronate was well tolerated by the patients. Only one patient discontinued treatment because of an adverse event (diarrhea) thought to be related to risedronate therapy.

  12. Prediction of Response to Medication and Cognitive Therapy in the Treatment of Moderate to Severe Depression

    PubMed Central

    Fournier, Jay C.; DeRubeis, Robert J.; Shelton, Richard C.; Hollon, Steven D.; Amsterdam, Jay D.; Gallop, Robert

    2009-01-01

    A recent randomized controlled trial found nearly equivalent response rates for antidepressant medications and cognitive therapy in a sample of moderate-to-severely depressed outpatients. In this article, we seek to identify the variables that were associated with response across both treatments as well as variables that predicted superior response in one treatment over the other. The sample consisted of 180 depressed outpatients: 60 of whom were randomly assigned to cognitive therapy; 120 were assigned to antidepressant medications. Treatment was provided for 16 weeks. Chronic depression, older age, and lower intelligence each predicted relatively poor response across both treatments. Three prescriptive variables were identified: marriage, unemployment, and having experienced a greater number of recent life events predicted superior response to cognitive therapy compared to antidepressant medications. Thus, six markers of treatment outcome were identified, each of which might be expected to carry considerable clinical utility. The three prognostic variables identify subgroups that might benefit from alternative treatment strategies; the three prescriptive variables identify groups who appear to respond particularly well to cognitive therapy. PMID:19634969

  13. Which treatment for alcohol dependence: naltrexone, acamprosate and/or behavioural intervention?

    PubMed

    Doggrell, Sheila A

    2006-10-01

    Alcoholism is the third leading cause of preventable mortality and morbidity in the US. In the COMBINE (Combined Pharmacotherapies and Behavioural Interventions) study, the co-primary end points were the percentage of days abstinent and the time to first heavy drinking day after 16 weeks, and 1 year. The biggest difference observed in COMBINE was that seen between combined behavioural intervention (CBI; percentage of abstinent days = 66.6%) and CBI and medical management with placebos (79.8%). This illustrated a major effect of the medical management of nine sessions and/or the placebo pills. Acamprosate had no effect alone or in combination with naltrexone. At 16 weeks with medical management, there were 75.1% of the patients who were abstinent for placebos, and this was improved by naltrexone, CBI, and naltrexone with CBI (80.6, 78.2 and 77.1%, respectively). There was a follow up after 1 year, which showed that, with medical management, the amount of those who were abstinent for placebos was 61.4%, and this was improved by naltrexone, CBI, and naltrexone with CBI (66.2, 66.6 and 67.3%, respectively), but this improvement no longer reached statistical significance. After 1 year, there was no difference between groups in the overall frequency of hospitalisation, emergency treatment for alcohol problems, use of medication for drinking or emotional problems and detoxification. Being part of a study for alcohol dependence is known to increase the percentage of abstinent days. In COMBINE, this percentage was high in the group having medical management and placebo pills, and naltrexone or additional behavioural therapy only had modest additional effects.

  14. 7 CFR 1280.613 - Voting period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Voting period. 1280.613 Section 1280.613 Agriculture... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.613 Voting period. The term voting period means a 4-week period to be announced by the Secretary for voting the referendum. Procedures...

  15. 7 CFR 1280.613 - Voting period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Voting period. 1280.613 Section 1280.613 Agriculture... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.613 Voting period. The term voting period means a 4-week period to be announced by the Secretary for voting the referendum. Procedures...

  16. 7 CFR 926.5 - Fiscal period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.5 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period... 7 Agriculture 8 2012-01-01 2012-01-01 false Fiscal period. 926.5 Section 926.5...

  17. 7 CFR 924.7 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on March 31 of... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 924.7 Section 924.7...

  18. 7 CFR 926.5 - Fiscal period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.5 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period... 7 Agriculture 8 2014-01-01 2014-01-01 false Fiscal period. 926.5 Section 926.5...

  19. 7 CFR 926.5 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.5 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 926.5 Section 926.5...

  20. 7 CFR 916.7 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulating Handling Definitions § 916.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period beginning on March 1 of one year and ending on the last day of February of the... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 916.7 Section 916.7...

  1. 7 CFR 926.5 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.5 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal period. 926.5 Section 926.5...

  2. 7 CFR 924.7 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on March 31 of... 7 Agriculture 8 2011-01-01 2011-01-01 false Fiscal period. 924.7 Section 924.7...

  3. 7 CFR 926.5 - Fiscal period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER § 926.5 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period... 7 Agriculture 8 2013-01-01 2013-01-01 false Fiscal period. 926.5 Section 926.5...

  4. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  5. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  6. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  7. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  8. 46 CFR 9.8 - Broken periods.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Broken periods. 9.8 Section 9.8 Shipping COAST GUARD... § 9.8 Broken periods. In computing extra compensation where the services rendered are in broken periods and less than 2 hours intervene between such broken periods the time served should be...

  9. Epigenetics in the perioperative period

    PubMed Central

    Lirk, P; Fiegl, H; Weber, N C; Hollmann, M W

    2015-01-01

    The perioperative period is characterized by profound changes in the body's homoeostatic processes. This review seeks to address whether epigenetic mechanisms may influence an individual's reaction to surgery and anaesthesia. Evidence from animal and human studies suggests that epigenetic mechanisms can explain many facets of susceptibility to acute and chronic pain, making them potential therapeutic targets. Modern pain management is still based upon opiates, and both the developmental expression of opioid receptors and opioid-induced hyperalgesia have been linked to epigenetic mechanisms. In general, opiates seem to increase global DNA methylation levels. This is in contrast to local anaesthetics, which have been ascribed a global demethylating effect. Even though no direct investigations have been carried out, the potential influence of epigenetics on the inflammatory response that follows surgery seems a promising area for research. There is a considerable body of evidence that supports the involvement of epigenetics in the complex process of wound healing. Epigenetics is an important emerging research topic in perioperative medicine, with a huge potential to positively influence patient outcome. PMID:25073649

  10. Critical period of weed control in aerobic rice.

    PubMed

    Anwar, M P; Juraimi, A S; Samedani, B; Puteh, A; Man, A

    2012-01-01

    Critical period of weed control is the foundation of integrated weed management and, hence, can be considered the first step to design weed control strategy. To determine critical period of weed control of aerobic rice, field trials were conducted during 2010/2011 at Universiti Putra Malaysia. A quantitative series of treatments comprising two components, (a) increasing duration of weed interference and (b) increasing length of weed-free period, were imposed. Critical period was determined through Logistic and Gompertz equations. Critical period varied between seasons; in main season, it started earlier and lasted longer, as compared to off-season. The onset of the critical period was found relatively stable between seasons, while the end was more variable. Critical period was determined as 7-49 days after seeding in off-season and 7-53 days in main season to achieve 95% of weed-free yield, and 23-40 days in off-season and 21-43 days in main season to achieve 90% of weed-free yield. Since 5% yield loss level is not practical from economic view point, a 10% yield loss may be considered excellent from economic view point. Therefore, aerobic rice should be kept weed-free during 21-43 days for better yield and higher economic return.

  11. Periodic motion near the surface of asteroids

    NASA Astrophysics Data System (ADS)

    Jiang, Yu; Baoyin, Hexi; Li, Hengnian

    2015-12-01

    We are interested in the periodic motion and bifurcations near the surface of an asteroid. The gravity field of an irregular asteroid and the equation of motion of a particle near the surface of an asteroid are studied. The periodic motions around the major body of triple asteroid 216 Kleopatra and the OSIRIS-REx mission target-asteroid 101955 Bennu are discussed. We find that motion near the surface of an irregular asteroid is quite different from the motion near the surface of a homoplastically spheroidal celestial body. The periodic motions around the asteroid 101955 Bennu and 216 Kleopatra indicate that the geometrical shapes of the orbits are probably very sophisticated. There exist both stable periodic motions and unstable periodic motions near the surface of the same irregular asteroid. This periodic motion which is unstable can be resonant or non-resonant. The period-doubling bifurcation and pseudo period-doubling bifurcation of periodic orbits coexist in the same gravity field of the primary of the triple asteroid 216 Kleopatra. It is found that both of the period-doubling bifurcations of periodic orbits and pseudo period-doubling bifurcation of periodic orbits have four different paths. The pseudo period-doubling bifurcation found in the potential field of primary of triple asteroid 216 Kleopatra shows that there exist stable periodic orbits near the primary's equatorial plane, which gives an explanation for the motion stability of the triple asteroid 216 Kleopatra's two moonlets, Alexhelios and Cleoselene.

  12. Child anxiety treatment: outcomes in adolescence and impact on substance use and depression at 7.4-year follow-up.

    PubMed

    Kendall, Philip C; Safford, Scott; Flannery-Schroeder, Ellen; Webb, Alicia

    2004-04-01

    Research suggests that the sequelae of childhood anxiety disorders, if left untreated, can include chronic anxiety, depression, and substance abuse. The current study evaluated the maintenance of outcomes of children who received a 16-week cognitive-behavioral treatment for primary anxiety disorders (generalized, separation, and social anxiety disorders) an average of 7.4 years earlier. The 86 participants (ages 15 to 22 years; 91% of the original sample) and their parents completed diagnostic interviews and self- and parent-report measures. According to the diagnostic interviews, a meaningful percentage of participants maintained significant improvements in anxiety at long-term follow-up. With regard to sequelae, positive responders to anxiety treatment, as compared with less positive responders, had a reduced amount of substance use involvement and related problems at long-term follow-up. The findings are discussed with regard to child anxiety and some of its sequelae. PMID:15065961

  13. A clinical trial of Integra Template for diabetic foot ulcer treatment.

    PubMed

    Driver, Vickie R; Lavery, Lawrence A; Reyzelman, Alexander M; Dutra, Timothy G; Dove, Cyaandi R; Kotsis, Sandra V; Kim, Hyungjin Myra; Chung, Kevin C

    2015-01-01

    Individuals with diabetes mellitus are at an increased risk of developing a diabetic foot ulcer (DFU). This study evaluated the safety and efficacy of Integra Dermal Regeneration Template (IDRT) for the treatment of nonhealing DFUs. The Foot Ulcer New Dermal Replacement Study was a multicenter, randomized, controlled, parallel group clinical trial conducted under an Investigational Device Exemption. Thirty-two sites enrolled and randomized 307 subjects with at least one DFU. Consented patients were entered into the 14-day run-in phase where they were treated with the standard of care (0.9% sodium chloride gel) plus a secondary dressing and an offloading/protective device. Patients with less than 30% reepithelialization of the study ulcer after the run-in phase were randomized into the treatment phase. The subjects were randomized to the control treatment group (0.9% sodium chloride gel; n = 153) or the active treatment group (IDRT, n = 154). The treatment phase was 16 weeks or until confirmation of complete wound closure (100% reepithelialization of the wound surface), whichever occurred first. Following the treatment phase, all subjects were followed for 12 weeks. Complete DFU closure during the treatment phase was significantly greater with IDRT treatment (51%) than control treatment (32%; p = 0.001) at sixteen weeks. The median time to complete DFU closure was 43 days for IDRT subjects and 78 days for control subjects in wounds that healed. The rate of wound size reduction was 7.2% per week for IDRT subjects vs. 4.8% per week for control subjects (p = 0.012). For the treatment of chronic DFUs, IDRT treatment decreased the time to complete wound closure, increased the rate of wound closure, improved components of quality of life and had less adverse events compared with the standard of care treatment. IDRT could greatly enhance the treatment of nonhealing DFUs.

  14. Hyperbaric treatment

    NASA Technical Reports Server (NTRS)

    Amoroso, Michael T.

    1990-01-01

    Viewgraphs on hyperbaric treatment are presented. Topics covered include: hyperbaric treatment - purpose; decompression sickness; sources of decompression sickness; physical description; forms of decompression sickness; hyperbaric treatment of decompression sickness; and duration of treatment.

  15. Elevated temperatures and long drought periods have a negative impact on survival and fitness of strongylid third stage larvae.

    PubMed

    Knapp-Lawitzke, Friederike; von Samson-Himmelstjerna, Georg; Demeler, Janina

    2016-04-01

    In grazing cattle, infections with gastrointestinal nematodes pose some of the most important health threats and subclinical infections result in considerable production losses. While there is little doubt that climate change will affect grazing ruminants directly, mean temperature increases of ∼ 3°C and longer drought stress periods in summer may also influence the free-living stages of parasitic nematodes. Hostile climatic conditions reduce the number of L3s on pasture and therefore the refugium, which is expected to result in a higher selection pressure, accelerating development of resistance against anthelmintic drugs. The aim of the current experiments was to investigate the effects of drought stress and different temperature/humidity ranges over time on the survival and fitness of Cooperia oncophora L3s and their distribution in grass and soil under controlled conditions using a climate chamber. Grass containers inoculated with L3s were analysed after 1-6weeks using descriptive statistics as well as linear models. A large proportion of L3s was recovered from soil where fitness was also better preserved than on grass. Numbers and fitness of recovered L3s declined with duration in the climate chamber under both temperature profiles. However, the results of the linear models confirmed that higher temperatures (20-33°C versus 17-22.6°C) significantly impaired survival, distribution and fitness of L3s. Application of drought stress, known as another important factor, had a surprisingly smaller impact than its duration or higher temperatures. The climate chamber enabled exclusion of confounding factors and therefore accurate interpretation of the investigated climatic aspects. The obtained results highlight the relative importance of those factors, and will help to design better models for the population dynamics of L3s on pasture in the future. Additionally, the outcomes of these investigations may offer explanations regarding interdependencies of development

  16. Optimal health insurance for multiple goods and time periods.

    PubMed

    Ellis, Randall P; Jiang, Shenyi; Manning, Willard G

    2015-05-01

    We examine the efficiency-based arguments for second-best optimal health insurance with multiple treatment goods and multiple time periods. Correlated shocks across health care goods and over time interact with complementarity and substitutability to affect optimal cost sharing. Health care goods that are substitutes or have positively correlated demand shocks should have lower optimal patient cost sharing. Positive serial correlations of demand shocks and uncompensated losses that are positively correlated with covered health services also reduce optimal cost sharing. Our results rationalize covering pharmaceuticals and outpatient spending more fully than is implied by static, one good, or one period models.

  17. Thyrotoxic Periodic Paralysis: A Case Report and Literature Review

    PubMed Central

    Barahona, M. J.; Vinagre, I.; Sojo, L.; Cubero, J. M.; Pérez, Antonio

    2009-01-01

    We describe a 37-year-old man with a 4-month history of episodic muscular weakness, involving mainly lower-limbs. Hypokalemia was documented in one episode and managed with intravenous potassium chloride. Hyperthyroidism was diagnosed 4 months after onset of attacks because of mild symptoms. The patient was subsequently diagnosed as having thyrotoxic periodic paralysis associated with Graves’ disease. Treatment with propranolol and methimazol was initiated and one year later he remains euthyroid and symptom free. Thyrotoxic periodic paralysis is a rare disorder, especially among Caucasians, but it should always be considered in patients with acute paralysis and hypokalemia, and thyroid function should be evaluated. PMID:19625499

  18. Reliability analysis of structures under periodic proof tests in service

    NASA Technical Reports Server (NTRS)

    Yang, J.-N.

    1976-01-01

    A reliability analysis of structures subjected to random service loads and periodic proof tests treats gust loads and maneuver loads as random processes. Crack initiation, crack propagation, and strength degradation are treated as the fatigue process. The time to fatigue crack initiation and ultimate strength are random variables. Residual strength decreases during crack propagation, so that failure rate increases with time. When a structure fails under periodic proof testing, a new structure is built and proof-tested. The probability of structural failure in service is derived from treatment of all the random variables, strength degradations, service loads, proof tests, and the renewal of failed structures. Some numerical examples are worked out.

  19. Man Made Elements Periodic Table, Astronomical Periodic Table, Geographic Periodic Table-Dimitri Mendeleev Imitation in the 21st Century

    NASA Astrophysics Data System (ADS)

    Struck, J.-T.

    2013-11-01

    A man made elements periodic table, including every single current element not just synthetic elements can be built differently than the naturally occurring element periodic table. Implications for knowing producible elements in space travel.

  20. Dearth of short-period Neptunian exoplanets: A desert in period-mass and period-radius planes

    NASA Astrophysics Data System (ADS)

    Mazeh, T.; Holczer, T.; Faigler, S.

    2016-05-01

    A few studies have reported a significant dearth of exoplanets with Neptune mass and radius with orbital periods below 2-4 d. This cannot be explained by observational biases because many Neptunian planets with longer orbital periods have been detected. The existence of this desert is similar to the appearance of the so-called brown-dwarf desert that suggests different formation mechanisms of planets and stellar companions with short orbital periods. Similarly, the Neptunian desert might indicate different mechanisms of formation and evolution for hot Jupiters and short-period super-Earths. We here follow a previous study and examine the location and shape of the desert in both the period-mass and period-radius planes, using the currently available large samples of planets. The desert in the period-mass plane has a relatively sharp upper edge, with a planetary mass that is inversely proportional to the planetary orbital period, while the lower, somewhat blurred, boundary is located along masses that are apparently linearly proportional to the period. The desert in the period-radius plane of the transiting planets is less clear. It seems as if the radius along the upper boundary is inversely proportional to the period to the power of one-third, while the lower boundary shows a radius that is proportional to the period to the power of two-thirds. The combination of the two upper bounds of the desert, in the period-mass and period-radius planes, yields a planetary mass-radius relation of Rp/RJup ≃ (1.2 ± 0.3)(Mp/MJup)0.27 ± 0.11 for 0.1 ≲ Mp/MJup ≲ 1. The derived shape of the desert, which might extend up to periods of 5-10 d, could shed some light on the formation and evolution of close-in planets.

  1. 7 CFR 1205.20 - Representative period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Representative period. 1205.20 Section 1205.20 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... period means the 2006 calendar year....

  2. Periodic behavior in a random environment.

    PubMed

    Broadbent, H A

    1994-04-01

    Animals' tendency to search periodically in temporally random environments was studied by presenting rats with random-interval (RI) 60-s and 120-s schedules. Power spectra revealed a periodicity of responding of 20-50 s for all animals regardless of condition. A second periodicity of 5-10-s was strongest under the RI 60-s schedule. Optimality theory suggests that periodic responding is better than random responding in obtaining food sooner on average, but the theory does not account for multiple periodicities. These multiple periodicities also cannot be explained by a single-oscillator, information-processing version of scalar expectancy theory (J. Gibbon & R. M. Church, 1992) or by the behavioral theory of timing (P.R. Killeen & J. G. Fetterman, 1988). The periodicities are consistent with a connectionist version of scalar expectancy theory that has nonscalar emergent properties, including multiple periodicities that are not proportional to the rate of random events.

  3. 25 CFR 140.11 - License period.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... is the owner or beneficial owner or holds a use right to the land on which the business is to be... land on which the business is to be conducted. The license period shall correspond to the period of...

  4. Continuing Diversity: A Column of Periodical Reviews.

    ERIC Educational Resources Information Center

    Juedes, D. R.

    1995-01-01

    Presents brief reviews of four periodicals that address diversity themes. Periodicals reviewed are: "Parabola: The Magazine of Myth and Traditions,""Race, Sex & Class: An Interdisciplinary Journal,""Third Force," and "Rhythm Music Magazine." Purchase information is included. (GR)

  5. 75 FR 65677 - Periodic Reporting Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... periodic reporting of service performance measurement for Applications and Mailing Permits, pursuant to... performance measurement reporting requirements. ADDRESSES: Submit comments electronically via the Commission's... Exception from Periodic Reporting of Service Performance Measurement, September 30, 2010 (Request); see...

  6. The two periods of TT ARIETIS

    NASA Astrophysics Data System (ADS)

    Thorstensen, J. R.; Smak, J.; Hessman, F. V.

    1985-05-01

    To clarify the spectroscopic period and demonstrate that the spectroscopic and photometric periods are distinct, velocities of the cataclysmic variable TT Ari in its high and intermediate photometric states are obtained. Evidence for periodicity is found near the period of Cowley et al. (1975) in both the high-state and intermediate-state velocities and in a reanalysis of the Cowley et al. velocities no evidence is found for periodicity near the photometric period. Since no single period fits all the data well and since the original Cowley et al. period fits all the high-state data quite well, it is shown that the velocities change phase between the high and the intermediate states. Results indicate that the intermediate-state velocities lag the high-state velocities by 0.28 of a cycle and that in the high-state data, the gamma velocities tend to be systematically lower for the high-order Balmer lines.

  7. Improved metabolic response after 16 weeks of calorie-restricted low-glycaemic index diet and metformin in impaired glucose tolerance subjects.

    PubMed

    Macedo da Costa, Teresa Helena; Pires da Silva, Fábio Vinícius; Gonçalves Reis, Caio Eduardo; Augusto Casulari, Luiz

    2014-05-01

    Objetivo: Este estudio analizaba los efectos metabólicos del consejo dietético de seguir una dieta con restricción calórica y un índice glucémico bajo junto con Metformina en individuos con sobrepeso / obesidad y tolerancia alterada a la glucosa. Métodos: Se siguió mensualmente durante 16 semanas a 16 individuos con un índice de masa corporal entre 27-38 kg/m² y se les trató con Metformina (1 g/día) y una prescripción dietética con un índice glucémico bajo y una reducción del energía del 25-30 ¡% de su gasto energético total. Se midieron el metabolismo de la glucosa, el perfil lipídico, la composición antropométrica y corporal y los parámetros de consumo de alimentos antes y después del tratamiento. Se emplearon las pruebas t pareadas y de Wilcoxon para comparar las diferencias con respecto al basal, con un criterio de significación estadística de p ≤0,05. Resultados: Hubo reducciones significativas en los parámetros de composición corporal y antropométricos, una disminución en las concentraciones de HOMA2-% y e triglicéridos y un aumento del índice de Cederholm. Estos resultados muestran una mejora de la sensibilidad periférica a la insulina y una conservación de la función de las células beta pancreáticas. Conclusión: la dieta con restricción calórica y un índice glucémico bajo junto con Metformina fueron beneficiosas para los parámetros metabólicos y antropométricos en individuos con sobrepeso/obesidad y una tolerancia a la glucosa alterada.

  8. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  9. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  10. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  11. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  12. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  13. Study of gratings with variable periods

    NASA Astrophysics Data System (ADS)

    Olivares-Pérez, Arturo; Fuentes-Tapia, Israel; Toxqui-López, Santa; Ortiz-Gutiérrez, Mauricio; Ordoñez-Padilla, Manuel Jorge; Mejias-Brizuela, Nildia Y.

    2016-03-01

    A theoretical study with sinusoidal amplitude diffraction gratings, elaborated with variable periods is shown. The diffraction pattern behavior and the symmetry degree of the gratings were observed. The grating period is increased, fringe to fringe, starting with a small period and ending with a big period that is; the grating edge, start with high spatial frequency and finish with low spatial frequency. This gratings modulation causes a widening in the diffracted orders.

  14. Liftings and stresses for planar periodic frameworks

    PubMed Central

    Borcea, Ciprian; Streinu, Ileana

    2015-01-01

    We formulate and prove a periodic analog of Maxwell’s theorem relating stressed planar frameworks and their liftings to polyhedral surfaces with spherical topology. We use our lifting theorem to prove deformation and rigidity-theoretic properties for planar periodic pseudo-triangulations, generalizing features known for their finite counterparts. These properties are then applied to questions originating in mathematical crystallography and materials science, concerning planar periodic auxetic structures and ultrarigid periodic frameworks. PMID:26973370

  15. 40 CFR 35.538 - Project period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Project period. 35.538 Section 35.538... ASSISTANCE Environmental Program Grants for Tribes Performance Partnership Grants § 35.538 Project period. If... that is added to a Performance Partnership Grant extends beyond the end of the project period for...

  16. 40 CFR 35.538 - Project period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Project period. 35.538 Section 35.538... ASSISTANCE Environmental Program Grants for Tribes Performance Partnership Grants § 35.538 Project period. If... that is added to a Performance Partnership Grant extends beyond the end of the project period for...

  17. 40 CFR 35.538 - Project period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Project period. 35.538 Section 35.538... ASSISTANCE Environmental Program Grants for Tribes Performance Partnership Grants § 35.538 Project period. If... that is added to a Performance Partnership Grant extends beyond the end of the project period for...

  18. 40 CFR 35.538 - Project period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Project period. 35.538 Section 35.538... ASSISTANCE Environmental Program Grants for Tribes Performance Partnership Grants § 35.538 Project period. If... that is added to a Performance Partnership Grant extends beyond the end of the project period for...

  19. 7 CFR 1437.5 - Coverage period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Coverage period. 1437.5 Section 1437.5 Agriculture... Provisions § 1437.5 Coverage period. (a) The coverage period is the time during which coverage is available against loss of production of the eligible crop as a result of natural disaster. (b) The coverage...

  20. Prebifurcation periodic ghost orbits in semiclassical quantization

    SciTech Connect

    Kus, M. ); Haake, F. ); Delande, D. )

    1993-10-04

    Classical periodic orbits are stationary-phase points in path integral representations of quantum propagators. We show that complex solutions of the stationary-phase equation, not corresponding to real classical periodic orbits, give additional contributions to the propagator which can be important, especially near bifurcations. We reveal the existence and relevance of such periodic ghost orbits for a kicked top.

  1. 21 CFR 573.240 - Calcium periodate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used in... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Calcium periodate. 573.240 Section 573.240...

  2. 21 CFR 573.240 - Calcium periodate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used in... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Calcium periodate. 573.240 Section 573.240...

  3. 21 CFR 573.240 - Calcium periodate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used in... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Calcium periodate. 573.240 Section 573.240...

  4. 21 CFR 573.240 - Calcium periodate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used in... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Calcium periodate. 573.240 Section 573.240...

  5. 21 CFR 573.240 - Calcium periodate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DRUGS, FEEDS, AND RELATED PRODUCTS FOOD ADDITIVES PERMITTED IN FEED AND DRINKING WATER OF ANIMALS Food Additive Listing § 573.240 Calcium periodate. The food additive calcium periodate may be safely used in... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Calcium periodate. 573.240 Section 573.240...

  6. 40 CFR 46.195 - Project period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Project period. 46.195 Section 46.195... During the Fellowship § 46.195 Project period. Based on the “Date Fellow Will Enter on Duty” which you enter on the Activation Notice (see § 46.185(a)), EPA will establish the project period for...

  7. 30 CFR 725.14 - Grant periods.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Grant periods. 725.14 Section 725.14 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.14 Grant periods. The Director or his authorized designee shall normally approve a grant for a period of one year or less. OSM shall fund a program that extends over...

  8. 49 CFR 236.588 - Periodic test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Periodic test. 236.588 Section 236.588..., Train Control and Cab Signal Systems Inspection and Tests; Locomotive § 236.588 Periodic test. Except as provided in § 236.586, periodic test of the automatic train stop, train control, or cab signal...

  9. 47 CFR 22.1035 - Construction period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Construction period. 22.1035 Section 22.1035 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1035 Construction period. The construction period (see § 22.142)...

  10. 30 CFR 725.14 - Grant periods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant periods. 725.14 Section 725.14 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.14 Grant periods. The Director or his authorized designee shall normally approve a grant for a period of one year or less. OSM shall fund a program that extends over...

  11. 30 CFR 887.13 - Grant period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... remaining at the end of any grant period to us according to 43 CFR part 12. ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant period. 887.13 Section 887.13 Mineral... LAND RECLAMATION SUBSIDENCE INSURANCE PROGRAM GRANTS § 887.13 Grant period. The grant funding...

  12. 30 CFR 887.13 - Grant period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... remaining at the end of any grant period to us according to 43 CFR part 12. ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant period. 887.13 Section 887.13 Mineral... LAND RECLAMATION SUBSIDENCE INSURANCE PROGRAM GRANTS § 887.13 Grant period. The grant funding...

  13. 30 CFR 725.14 - Grant periods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Grant periods. 725.14 Section 725.14 Mineral... REGULATIONS REIMBURSEMENTS TO STATES § 725.14 Grant periods. The Director or his authorized designee shall normally approve a grant for a period of one year or less. OSM shall fund a program that extends over...

  14. 39 CFR 3055.55 - Periodicals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Periodicals. 3055.55 Section 3055.55 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL SERVICE PERFORMANCE AND CUSTOMER SATISFACTION REPORTING Periodic Reporting of Service Performance Achievements § 3055.55 Periodicals. (a) Within County...

  15. 12 CFR 226.7 - Periodic statement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM TRUTH... periodic rates apply to different types of transactions, the types of transactions to which the periodic... amount(s) of any other type of finance charge. If there is more than one periodic rate, the amount of...

  16. 7 CFR 1230.621 - Voting period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures for the Conduct of Referendum Definitions § 1230.621 Voting period. The term Voting period means the 3-consecutive business day period for in-person voting. Referendum...

  17. 7 CFR 1230.621 - Voting period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND CONSUMER INFORMATION Procedures for the Conduct of Referendum Definitions § 1230.621 Voting period. The term Voting period means the 3-consecutive business day period for in-person voting. Referendum...

  18. 32 CFR 552.80 - Suspension period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Suspension period. 552.80 Section 552.80 National... Suspension period. All solicitation privileges suspended by installation commanders will be for a specific time. Normally, it will not exceed 2 years. When the suspension period expires, the agent may...

  19. 32 CFR 552.80 - Suspension period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Suspension period. 552.80 Section 552.80 National... Suspension period. All solicitation privileges suspended by installation commanders will be for a specific time. Normally, it will not exceed 2 years. When the suspension period expires, the agent may...

  20. 5 CFR 9901.411 - Appraisal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....411 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS... PERSONNEL SYSTEM (NSPS) Performance Management § 9901.411 Appraisal period. (a) Except as provided in... period, an employee has not met the minimum period of performance, management may extend the...

  1. 10 CFR 603.1295 - Periodic audit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Periodic audit. 603.1295 Section 603.1295 Energy... Used in this Part § 603.1295 Periodic audit. An audit of a participant, performed at an agreed-upon... an audit may cover. A periodic audit of a participant differs from an award-specific audit of...

  2. 32 CFR 37.1325 - Periodic audit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Periodic audit. 37.1325 Section 37.1325 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1325 Periodic audit. An audit of... awards. Appendix C to this part describes what such an audit may cover. A periodic audit of a...

  3. 40 CFR 35.108 - Funding period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program...

  4. 40 CFR 35.508 - Funding period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Funding period. 35.508 Section 35.508... ASSISTANCE Environmental Program Grants for Tribes Preparing An Application § 35.508 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for...

  5. 40 CFR 35.108 - Funding period.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program...

  6. 40 CFR 35.508 - Funding period.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Funding period. 35.508 Section 35.508... ASSISTANCE Environmental Program Grants for Tribes Preparing An Application § 35.508 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for...

  7. 40 CFR 35.508 - Funding period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Funding period. 35.508 Section 35.508... ASSISTANCE Environmental Program Grants for Tribes Preparing An Application § 35.508 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for...

  8. 40 CFR 35.108 - Funding period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program...

  9. 40 CFR 35.108 - Funding period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program...

  10. 40 CFR 35.508 - Funding period.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Funding period. 35.508 Section 35.508... ASSISTANCE Environmental Program Grants for Tribes Preparing An Application § 35.508 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for...

  11. 40 CFR 35.108 - Funding period.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Funding period. 35.108 Section 35.108... ASSISTANCE Environmental Program Grants Preparing An Application § 35.108 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for environmental program...

  12. 40 CFR 35.508 - Funding period.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding period. 35.508 Section 35.508... ASSISTANCE Environmental Program Grants for Tribes Preparing An Application § 35.508 Funding period. The Regional Administrator and applicant may negotiate the length of the funding period for...

  13. 14 CFR 325.6 - Periodic reviews.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Periodic reviews. 325.6 Section 325.6... REGULATIONS ESSENTIAL AIR SERVICE PROCEDURES § 325.6 Periodic reviews. (a) The Department will start a periodic review of essential air service within 1 year of the date of the previous determination...

  14. 14 CFR 413.15 - Review period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Review period. 413.15 Section 413.15... TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.15 Review period. (a) Review period duration. Unless otherwise specified in this chapter, the FAA reviews and makes a decision on an application...

  15. 46 CFR Sec. 5 - Idle status period.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Idle status period. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Sec. 5 Idle status period. (a) The General Agent shall place a vessel in idle status during the period of reactivation...

  16. 46 CFR Sec. 5 - Idle status period.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Idle status period. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Sec. 5 Idle status period. (a) The General Agent shall place a vessel in idle status during the period of reactivation...

  17. 46 CFR Sec. 5 - Idle status period.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Idle status period. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Sec. 5 Idle status period. (a) The General Agent shall place a vessel in idle status during the period of reactivation...

  18. 46 CFR Sec. 5 - Idle status period.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Idle status period. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Sec. 5 Idle status period. (a) The General Agent shall place a vessel in idle status during the period of reactivation...

  19. 46 CFR Sec. 5 - Idle status period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Idle status period. Sec. 5 Section 5 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY VOYAGE DATA Sec. 5 Idle status period. (a) The General Agent shall place a vessel in idle status during the period of reactivation...

  20. 5 CFR 9901.411 - Appraisal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....411 Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS... PERSONNEL SYSTEM (NSPS) Performance Management § 9901.411 Appraisal period. (a) Except as provided in... period, an employee has not met the minimum period of performance, management may extend the...

  1. 14 CFR 413.15 - Review period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Review period. 413.15 Section 413.15 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.15 Review period. (a) Review period duration. Unless otherwise specified in this...

  2. 14 CFR 413.15 - Review period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Review period. 413.15 Section 413.15 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.15 Review period. (a) Review period duration. Unless otherwise specified in this...

  3. 14 CFR 413.15 - Review period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Review period. 413.15 Section 413.15 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.15 Review period. (a) Review period...

  4. 14 CFR 413.15 - Review period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Review period. 413.15 Section 413.15 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.15 Review period. (a) Review period duration. Unless otherwise specified in this...

  5. 16 CFR 1107.21 - Periodic testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... body. Periodic testing must be conducted pursuant to either paragraph (b), (c), or (d) of this section.... Component part testing pursuant to 16 CFR part 1109 may be used to support the periodic testing requirements... assessment body for periodic testing to the applicable children's product safety rules at least once...

  6. 16 CFR 1107.21 - Periodic testing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... body. Periodic testing must be conducted pursuant to either paragraph (b), (c), or (d) of this section.... Component part testing pursuant to 16 CFR part 1109 may be used to support the periodic testing requirements... assessment body for periodic testing to the applicable children's product safety rules at least once...

  7. 32 CFR 37.1325 - Periodic audit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Periodic audit. 37.1325 Section 37.1325 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1325 Periodic audit. An audit of... awards. Appendix C to this part describes what such an audit may cover. A periodic audit of a...

  8. 47 CFR 22.1035 - Construction period.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Construction period. 22.1035 Section 22.1035 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1035 Construction period. The construction period (see § 22.142)...

  9. 47 CFR 22.1035 - Construction period.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Construction period. 22.1035 Section 22.1035 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1035 Construction period. The construction period (see § 22.142)...

  10. 47 CFR 22.1035 - Construction period.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Construction period. 22.1035 Section 22.1035 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1035 Construction period. The construction period (see § 22.142)...

  11. 47 CFR 22.1035 - Construction period.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Construction period. 22.1035 Section 22.1035 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Offshore Radiotelephone Service § 22.1035 Construction period. The construction period (see § 22.142)...

  12. [Popular knowledge about medicaments in 19th century periodicals].

    PubMed

    Arabas, Iwona

    2004-01-01

    Polish periodicals published since the beginning of 19th century contained household knowledge which was of great importance to peasants. In the second half of 19th century the number of articles related to prevention, treatment as well as life hygiene (including nutrition guidance) enlarged significantly. The term "household medicine box# was very often used in periodicals as titles of both: sections dedicated to hygiene or medicine as well as for articles describing medicaments intended to be kept in the boxes. Articles referenced law regulations stated in "law for pharmacists and pharmacies# from 1844. The availability of medical handbooks widened with the end of the century and this fact may have caused the changes in profiles of numerous medical sections in popular periodicals. However the changes did not affect publications related to contents of medical boxes.

  13. Suicide during Perinatal Period: Epidemiology, Risk Factors, and Clinical Correlates

    PubMed Central

    Orsolini, Laura; Valchera, Alessandro; Vecchiotti, Roberta; Tomasetti, Carmine; Iasevoli, Felice; Fornaro, Michele; De Berardis, Domenico; Perna, Giampaolo; Pompili, Maurizio; Bellantuono, Cesario

    2016-01-01

    Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide has been considered a relatively rare event during the perinatal period. However, in some mental disorders (i.e., postpartum depression, bipolar disorder, postpartum psychosis, etc.) have been reported a higher risk of suicidal ideation, suicide attempt, or suicide. Therefore, a complete screening of mothers’ mental health should also take into account thoughts of suicide and thoughts about harming infants as well. Clinicians should carefully monitor and early identify related clinical manifestations, potential risk factors, and alarm symptoms related to suicide. The present paper aims at providing a focused review about epidemiological data, risk factors, and an overview about the main clinical correlates associated with the suicidal behavior during the pregnancy and postpartum period. Practical recommendations have been provided as well. PMID:27570512

  14. Suicide during Perinatal Period: Epidemiology, Risk Factors, and Clinical Correlates.

    PubMed

    Orsolini, Laura; Valchera, Alessandro; Vecchiotti, Roberta; Tomasetti, Carmine; Iasevoli, Felice; Fornaro, Michele; De Berardis, Domenico; Perna, Giampaolo; Pompili, Maurizio; Bellantuono, Cesario

    2016-01-01

    Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide has been considered a relatively rare event during the perinatal period. However, in some mental disorders (i.e., postpartum depression, bipolar disorder, postpartum psychosis, etc.) have been reported a higher risk of suicidal ideation, suicide attempt, or suicide. Therefore, a complete screening of mothers' mental health should also take into account thoughts of suicide and thoughts about harming infants as well. Clinicians should carefully monitor and early identify related clinical manifestations, potential risk factors, and alarm symptoms related to suicide. The present paper aims at providing a focused review about epidemiological data, risk factors, and an overview about the main clinical correlates associated with the suicidal behavior during the pregnancy and postpartum period. Practical recommendations have been provided as well. PMID:27570512

  15. Pulmonary artery stump thrombosis developed during the late postoperative period

    PubMed Central

    Kaya, Seyda Ors; Samancilar, Ozgur; Ceylan, Kenan Can

    2016-01-01

    A 73-year-old man underwent left pneumonectomy for squamous cell lung carcinoma 3 years ago. The postoperative and follow-up periods were uneventful. A thrombus was detected in the left pulmonary artery stump during the last chest computed tomography (CT) scan. Anticoagulant treatment was applied: intravenous heparin for 3 days followed by oral warfarin. The follow-up chest CT examination revealed regression in the size of the thrombus.

  16. Light period regulation of carbohydrate partitioning

    NASA Technical Reports Server (NTRS)

    Janes, Harry W.

    1994-01-01

    We have shown that the photosynthetic period is important in regulating carbon partitioning. Even when the same amount of carbon is fixed over a 24h period considerably more is translocated out of the leaf under the longer photosynthetic period. This is extremely important when parts of the plant other than the leaves are to be sold. It is also important to notice the amount of carbon respired in the short photosynthetic period. The light period effect on carbohydrate fixation, dark respiration, and translocation is shown in this report.

  17. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome.

    PubMed

    Ali, Nora S; Sartori-Valinotti, Julio C; Bruce, Alison J

    2016-01-01

    Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, the most common periodic disorder of childhood, presents with the cardinal symptoms of periodic fever, aphthous stomatitis, pharyngitis, and adenitis typically before age 5. This review presents the recent literature on PFAPA and summarizes key findings in the pathogenesis, evaluation, and treatment of the disease. Theories surrounding the pathogenesis of PFAPA include a faulty innate immunologic response in conjunction with dysregulated T-cell activation. A potential genetic link is also under consideration. Mediterranean fever (MEFV) gene variants have been implicated and appear to modify disease severity. In individuals with the heterozygous variant, PFAPA episodes are milder and shorter in duration. Diagnostic criteria include the traditional clinical signs, in addition to the following biomarkers: elevated C-reactive protein in the absence of elevated procalcitonin, vitamin D, CD64, mean corpuscular volume, and other nonspecific inflammatory mediators in the absence of an infectious explanation for fever. Treatment of PFAPA includes tonsillectomy, a single dose of corticosteroids, and, most recently, interleukin 1 blockers such as anakinra, rilonacept, and canakinumab. Tonsillectomy remains the only permanent treatment modality. PMID:27343963

  18. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.

    PubMed

    Klupp, Nerida L; Kiat, Hosen; Bensoussan, Alan; Steiner, Genevieve Z; Chang, Dennis H

    2016-01-01

    This study aimed to evaluate the efficacy and safety of Ganoderma lucidum for the treatment of hyperglycaemia and other cardiovascular risk components of metabolic syndrome using a prospective, double-blind, randomised, placebo-controlled trial. Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma lucidum, with or without Cordyceps sinensis, for 16 weeks. The primary outcome measure was blood glucose (glycosylated haemoglobin [HbA1c] and fasting plasma glucose [FPG]); a number of secondary outcome measures were also tested. Data from the two intervention groups were combined. The combined intervention had no effect on any of the primary (baseline-adjusted difference in means: HbA1c = 0.13%, 95% CI [-0.35, 0.60], p = 0.60; FPG = 0.03 mmol/L, 95% CI [-0.90, 0.96], p = 0.95) or secondary outcome measures over the course of the 16-week trial, and no overall increased risk of adverse events with either active treatment. Evidence from this randomised clinical trial does not support the use of Ganoderma lucidum for treatment of cardiovascular risk factors in people with diabetes mellitus or metabolic syndrome. This Clinical Trial was registered with the Australian New Zealand Clinical Trials Registry on November 23, 2006. Trial ID: ACTRN12606000485538 and can be accessed here: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=81705. PMID:27511742

  19. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome

    PubMed Central

    Klupp, Nerida L.; Kiat, Hosen; Bensoussan, Alan; Steiner, Genevieve Z.; Chang, Dennis H.

    2016-01-01

    This study aimed to evaluate the efficacy and safety of Ganoderma lucidum for the treatment of hyperglycaemia and other cardiovascular risk components of metabolic syndrome using a prospective, double-blind, randomised, placebo-controlled trial. Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma lucidum, with or without Cordyceps sinensis, for 16 weeks. The primary outcome measure was blood glucose (glycosylated haemoglobin [HbA1c] and fasting plasma glucose [FPG]); a number of secondary outcome measures were also tested. Data from the two intervention groups were combined. The combined intervention had no effect on any of the primary (baseline-adjusted difference in means: HbA1c = 0.13%, 95% CI [−0.35, 0.60], p = 0.60; FPG = 0.03 mmol/L, 95% CI [−0.90, 0.96], p = 0.95) or secondary outcome measures over the course of the 16-week trial, and no overall increased risk of adverse events with either active treatment. Evidence from this randomised clinical trial does not support the use of Ganoderma lucidum for treatment of cardiovascular risk factors in people with diabetes mellitus or metabolic syndrome. This Clinical Trial was registered with the Australian New Zealand Clinical Trials Registry on November 23, 2006. Trial ID: ACTRN12606000485538 and can be accessed here: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=81705. PMID:27511742

  20. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.

    PubMed

    Klupp, Nerida L; Kiat, Hosen; Bensoussan, Alan; Steiner, Genevieve Z; Chang, Dennis H

    2016-08-11

    This study aimed to evaluate the efficacy and safety of Ganoderma lucidum for the treatment of hyperglycaemia and other cardiovascular risk components of metabolic syndrome using a prospective, double-blind, randomised, placebo-controlled trial. Eighty-four participants with type 2 diabetes mellitus and metabolic syndrome were randomised to one of three intervention groups: Ganoderma lucidum, Ganoderma lucidum with Cordyceps sinensis, or placebo. The dosage was 3 g/day of Ganoderma lucidum, with or without Cordyceps sinensis, for 16 weeks. The primary outcome measure was blood glucose (glycosylated haemoglobin [HbA1c] and fasting plasma glucose [FPG]); a number of secondary outcome measures were also tested. Data from the two intervention groups were combined. The combined intervention had no effect on any of the primary (baseline-adjusted difference in means: HbA1c = 0.13%, 95% CI [-0.35, 0.60], p = 0.60; FPG = 0.03 mmol/L, 95% CI [-0.90, 0.96], p = 0.95) or secondary outcome measures over the course of the 16-week trial, and no overall increased risk of adverse events with either active treatment. Evidence from this randomised clinical trial does not support the use of Ganoderma lucidum for treatment of cardiovascular risk factors in people with diabetes mellitus or metabolic syndrome. This Clinical Trial was registered with the Australian New Zealand Clinical Trials Registry on November 23, 2006. Trial ID: ACTRN12606000485538 and can be accessed here: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=81705.

  1. A highly specific test for periodicity

    SciTech Connect

    Ansmann, Gerrit

    2015-11-15

    We present a method that allows to distinguish between nearly periodic and strictly periodic time series. To this purpose, we employ a conservative criterion for periodicity, namely, that the time series can be interpolated by a periodic function whose local extrema are also present in the time series. Our method is intended for the analysis of time series generated by deterministic time-continuous dynamical systems, where it can help telling periodic dynamics from chaotic or transient ones. We empirically investigate our method's performance and compare it to an approach based on marker events (or Poincaré sections). We demonstrate that our method is capable of detecting small deviations from periodicity and outperforms the marker-event-based approach in typical situations. Our method requires no adjustment of parameters to the individual time series, yields the period length with a precision that exceeds the sampling rate, and its runtime grows asymptotically linear with the length of the time series.

  2. Long Periodic Terms in the Solar System

    NASA Technical Reports Server (NTRS)

    Bretagnon, P.

    1982-01-01

    The long period variations of the first eight planets in the solar system are studied. First, the Lagrangian solution is calculated and then the long period terms with fourth order eccentricities and inclinations are introduced into the perturbation function. A second approximation was made taking into account the short period terms' contribution, namely the perturbations of first order with respect to the masses. Special attention was paid to the determination of the integration constants. The relative importance of the different contributions is shown. It is useless, for example, to introduce the long period terms of fifth order if no account has been taken of the short period terms. Meanwhile, the terms that have been neglected would not introduce large changes in the integration constants. Even so, the calculation should be repeated with higher order short period terms and fifth order long periods.

  3. Sawtooth period control by power modulation

    NASA Astrophysics Data System (ADS)

    Lauret, Menno; Schuster, Eugenio; de Baar, Marco; Felici, Federico; Heemels, Maurice; Gomes, Alexander; Goodman, Tim; Kim, Doohyun; Sauter, Olivier; Vandersteen, Gerd; Witvoet, Gert; Lennholm, Morten

    2015-11-01

    It is foreseen that long sawtooth oscillations will occur during ITER H-mode scenarios leading to confinement loss and even disruptions. Sawtooth period control is therefore crucial. Most sawtooth period control approaches depend on changing the deposition location of electron-cyclotron current drive (ECCD) near r(q =1). In contrast to this, several TCV and AUG experiments with fixed ECCD deposition location show that ECCD power modulation, either periodic or feedback controlled, can lead to fast and reliable period control. To understand this nonlinear phenomenon, a reduced and `hybrid' reset model has been derived that models the nonlinear dynamics. Analysis reveals that the sawtooth period can be controlled by power modulation, even in the case of significant model uncertainties or when there is a significant lengthening effect of the fast particles on the sawtooth period, as there will be in ITER. The model can also be used to design period control using ICRH influencing this fast particle effect.

  4. Talbot effect of quasi-periodic grating.

    PubMed

    Zhang, Chong; Zhang, Wei; Li, Furui; Wang, Junhong; Teng, Shuyun

    2013-07-20

    Theoretic and experimental studies of the Talbot effect of quasi-periodic gratings are performed in this paper. The diffractions of periodic and quasi-periodic square aperture arrays in Fresnel fields are analyzed according to the scalar diffraction theory. The expressions of the diffraction intensities of two types of quasi-periodic gratings are deduced. Talbot images of the quasi-periodic gratings are predicted to appear at multiple certain distances. The quasi-periodic square aperture arrays are produced with the aid of a liquid crystal light modulator, and the self-images of the quasi-periodic gratings are measured successfully in the experiment. This study indicates that even a structure in short-range disorder may take on the self-imaging effect in a Fresnel field. PMID:23872752

  5. Long periodic terms in the solar system

    NASA Astrophysics Data System (ADS)

    Bretagnon, P.

    1982-06-01

    The long period variations of the first eight planets in the solar system are studied. First, the Lagrangian solution is calculated and then the long period terms with fourth order eccentricities and inclinations are introduced into the perturbation function. A second approximation was made taking into account the short period terms' contribution, namely the perturbations of first order with respect to the masses. Special attention was paid to the determination of the integration constants. The relative importance of the different contributions is shown. It is useless, for example, to introduce the long period terms of fifth order if no account has been taken of the short period terms. Meanwhile, the terms that have been neglected would not introduce large changes in the integration constants. Even so, the calculation should be repeated with higher order short period terms and fifth order long periods.

  6. Behavioral Weight Loss Treatment in Antipsychotic Treated Youth

    PubMed Central

    Nicol, Ginger E.; Kolko, Rachel P.; Mills, Monica; Gunnarsdottir, Thrudur; Yingling, Michael D.; Schweiger, Julia A.; Lenze, Eric J.; Newcomer, John W.; Wilfley, Denise

    2016-01-01

    Background Antipsychotic-treated youth have increased risk for the development of obesity and type 2 diabetes. Behavioral weight loss treatments show promise in reducing obesity and diabetes risk in antipsychotic treated adults, but have received no study in antipsychotic treated youth. Objective We describe a rationale for behavioral weight loss interventions in high-weight antipsychotic treated youth, and report behavioral, anthropomorphic, and metabolic findings from a case series of obese antipsychotic-treated adolescents participating in a short-term, family-based behavioral weight loss intervention. Methods We adapted the Traffic Light Plan, a 16-week family-based weight loss intervention that promotes healthy energy balance using the colors of the traffic light to categorize the nutritional value of foods and intensity of physical activity, adapting a social ecological framework to address health behavior change in multiple social contexts. The intervention was administered to three obese adolescents with long-term antipsychotic medication exposure. Efficacy of the intervention was evaluated with a battery of anthropomorphic and metabolic assessments including weight, body mass index percentile, whole body adiposity, liver fat content, and fasting plasma glucose and lipids. Participants and their parents also filled out a treatment satisfaction questionnaire upon study completion. Results Two males and 1 female (all aged 14 years) participated. All 3 participants attended all 16 sessions, and experienced beneficial changes in adiposity, fasting lipids and liver fat content associated with weight stabilization or weight loss. Adolescents and their parents all reported a high level of satisfaction with the treatment. Conclusions Family-based behavioral weight loss treatment can be feasibly delivered and is acceptable to antipsychotic-treated youth and their families. Randomized controlled trials are needed to fully evaluate the effectiveness and acceptability

  7. Effect of starting body fat content and genotype of laying hens on the changes in their live weight, body fat content, egg production and egg composition during the first egg-laying period.

    PubMed

    Milisits, G; Szentirmai, E; Donkó, T; Budai, Z; Ujvári, J; Áprily, S; Bajzik, G; Sütő, Z

    2015-01-01

    A total 120 laying hens (60 TETRA BLANCA white egg layers and 60 TETRA SL brown egg layers) were selected from 250 TETRA BLANCA and 250 TETRA SL pullets based on their predicted body fat content by means of computed tomography (CT) at 16 weeks of age. Three groups of pullets were chosen for the investigation with the highest (n = 20), lowest (n = 20) and average (n = 20) body fat content. Changes in the live weight, body fat content, egg production and egg composition of the chosen animals were recorded at 32, 52 and 72 weeks of age. Based on the results, it was established that differences in starting body fat content of the hens remained the same during the experimental period. The differences between the two extreme groups were statistically significant at each age. The starting body fat content of the hens affected the rate of egg production, i.e. hens with high starting body fat content produced 11-14 eggs fewer than the hens with a low or average body fat content but had no effect on the composition of the eggs. Genotype affected almost all of the examined traits: TETRA BLANCA hens had lower live weight and higher body fat content during the experimental period and produced fewer eggs with lower albumen and higher yolk, dry matter and crude fat content than the TETRA SL hens.

  8. Seismic isolation of two dimensional periodic foundations

    SciTech Connect

    Yan, Y.; Mo, Y. L.; Laskar, A.; Cheng, Z.; Shi, Z.; Menq, F.; Tang, Y.

    2014-07-28

    Phononic crystal is now used to control acoustic waves. When the crystal goes to a larger scale, it is called periodic structure. The band gaps of the periodic structure can be reduced to range from 0.5 Hz to 50 Hz. Therefore, the periodic structure has potential applications in seismic wave reflection. In civil engineering, the periodic structure can be served as the foundation of upper structure. This type of foundation consisting of periodic structure is called periodic foundation. When the frequency of seismic waves falls into the band gaps of the periodic foundation, the seismic wave can be blocked. Field experiments of a scaled two dimensional (2D) periodic foundation with an upper structure were conducted to verify the band gap effects. Test results showed the 2D periodic foundation can effectively reduce the response of the upper structure for excitations with frequencies within the frequency band gaps. When the experimental and the finite element analysis results are compared, they agree well with each other, indicating that 2D periodic foundation is a feasible way of reducing seismic vibrations.

  9. HeteroGenome: database of genome periodicity

    PubMed Central

    Chaley, Maria; Kutyrkin, Vladimir; Tulbasheva, Gayane; Teplukhina, Elena; Nazipova, Nafisa

    2014-01-01

    We present the first release of the HeteroGenome database collecting latent periodicity regions in genomes. Tandem repeats and highly divergent tandem repeats along with the regions of a new type of periodicity, known as profile periodicity, have been collected for the genomes of Saccharomyces cerevisiae, Arabidopsis thaliana, Caenorhabditis elegans and Drosophila melanogaster. We obtained data with the aid of a spectral-statistical approach to search for reliable latent periodicity regions (with periods up to 2000 bp) in DNA sequences. The original two-level mode of data presentation (a broad view of the region of latent periodicity and a second level indicating conservative fragments of its structure) was further developed to enable us to obtain the estimate, without redundancy, that latent periodicity regions make up ∼10% of the analyzed genomes. Analysis of the quantitative and qualitative content of located periodicity regions on all chromosomes of the analyzed organisms revealed dominant characteristic types of periodicity in the genomes. The pattern of density distribution of latent periodicity regions on chromosome unambiguously characterizes each chromosome in genome. Database URL: http://www.jcbi.ru/lp_baze/ PMID:24857969

  10. Probabilistic stellar rotation periods with Gaussian processes

    NASA Astrophysics Data System (ADS)

    Angus, Ruth; Aigrain, Suzanne; Foreman-Mackey, Daniel

    2015-08-01

    Stellar rotation has many applications in the field of exoplanets. High-precision photometry from space-based missions like Kepler and K2 allows us to measure stellar rotation periods directly from light curves. Stellar variability produced by rotation is usually not sinusoidal or perfectly periodic, therefore sine-fitting periodograms are not well suited to rotation period measurement. Autocorrelation functions are often used to extract periodic information from light curves, however uncertainties on rotation periods measured by autocorrelation are difficult to define. A ‘by eye’ check, or a set of heuristic criteria are used to validate measurements and rotation periods are only reported for stars that pass this vetting process. A probabilistic rotation period measurement method, with a suitable generative model bypasses the need for a validation stage and can produce realistic uncertainties. The physics driving the production of variability in stellar light curves is still poorly understood and difficult to model. We therefore use an effective model for stellar variability: a Gaussian process with a quasi-periodic covariance function. By injecting fake signals into Kepler light curves we show that the GP model is well suited to quasi-periodic, non-sinusoidal signals, is capable of modelling noise and physical signals simultaneously and provides probabilistic rotation period measurements with realistic uncertainties.

  11. Cyclical period changes in Z Chamaeleontis

    NASA Astrophysics Data System (ADS)

    Baptista, R.; Jablonski, F.; Oliveira, E.; Vrielmann, S.; Woudt, P. A.; Catalán, M. S.

    2002-09-01

    We report the identification of cyclical changes in the orbital period of the eclipsing dwarf nova Z Cha. We used times of mid-eclipse collected from the literature and our new eclipse timings to construct an observed-minus-calculated diagram covering 30 yr of observations (1972-2002). The data present cyclical variations that can be fitted by a linear plus sinusoidal function with period 28 +/- 2 yr and amplitude 1.0 +/- 0.2 min. The statistical significance of this period by an F-test is larger than 99.9 per cent. The derived fractional period change, ΔP/P= 4.4 × 10-7, is comparable to that of other short-period cataclysmic variables (CVs), but is one order of magnitude smaller than those of the long-period CVs. Separate fits to the first and second halves of the data lead to ephemerides with quite different cycle periods and amplitudes, indicating that the variation is not sinusoidal or, most probably, is not strictly periodic. The observed cyclical period change is possibly caused by a solar-type magnetic activity cycle in the secondary star. An incremental variation in the Roche lobe of the secondary star of is required in order to explain both the observed period change and the modulation of the quiescent brightness previously reported by Ak, Ozkan & Mattei.

  12. Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles

    PubMed Central

    Paithankar, Dilip Y; Sakamoto, Fernanda H; Farinelli, William A; Kositratna, Garuna; Blomgren, Richard D; Meyer, Todd J; Faupel, Linda J; Kauvar, Arielle N B; Lloyd, Jenifer R; Cheung, Wang L; Owczarek, Witold D; Suwalska, Anna M; Kochanska, Katarzyna B; Nawrocka, Agnieszka K; Paluchowska, Elwira B; Podolec, Katarzyna M; Pirowska, Magdalena M; Wojas-Pelc, Anna B; Anderson, R Rox

    2015-01-01

    The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could be delivered into sebaceous glands, enabling local injury by optical pulses. A suspension of topically applied gold-coated silica microparticles exhibiting plasmon resonance with strong absorption at 800 nm was delivered into human pre-auricular and swine sebaceous glands in vivo, using mechanical vibration. After exposure to 10–50 J cm−2, 30 milliseconds, 800 nm diode laser pulses, microscopy revealed preferential thermal injury to sebaceous follicles and glands, consistent with predictions from a computational model. Inflammation was mild; gold particles were not retained in swine skin 1 month after treatment, and uptake in other organs was negligible. Two independent prospective randomized controlled clinical trials were performed for treatment of moderate-to-severe facial acne, using unblinded and blinded assessments of disease severity. Each trial showed clinically and statistically significant improvement of inflammatory acne following three treatments given 1–2 weeks apart. In Trial 2, inflammatory lesions were significantly reduced at 12 weeks (P=0.015) and 16 weeks (P=0.04) compared with sham treatments. Optical microparticles enable selective photothermolysis of sebaceous glands. This appears to be a well-tolerated, effective treatment for acne vulgaris. PMID:25748556

  13. Trachoma in late Greek antiquity and the early Byzantine periods.

    PubMed

    Trompoukis, Constantinos; Kourkoutas, Dimitrios

    2007-12-01

    Trachoma is an ancient disease that has survived until the present day and represents the most common cause of infectious blindness globally. This study reviews the main Greek medical sources of the period from the 1st to 7th century AD and presents the medical knowledge relating to trachoma, including its definition, clinical features, diagnosis, complications, and treatment. It was widely accepted that trachoma was a disease of the palpebral conjunctiva, and the different stages of trachoma were described in detail. However, it is unclear whether the stages of trichiasis and pannus were identified as trachoma complications. The extensive references to the treatment of trachoma during the Byzantine period provide a strong argument for the case that trachoma was one of the most serious and common eye diseases. Both surgical and pharmaceutical treatments were often applied at the same time. Occasionally, surgical treatment could be rather dramatic, involving the use of stiff fig leaves or a chisel. Nevertheless, the prognosis was always poor, and the disease developed over the years until it threatened the cornea.

  14. Do triatomic molecules echo atomic periodicity?

    SciTech Connect

    Hefferlin, R. Barrow, J.

    2015-03-30

    Demonstrations of periodicity among triatomic-molecular spectroscopic constants underscore the role of the periodic law as a foundation of chemistry. The objective of this work is to prepare for another test using vibration frequencies ν{sub 1} of free, ground-state, main-group triatomic molecules. Using data from four data bases and from computation, we have collected ν{sub 1} data for molecules formed from second period atoms.

  15. Long period coupling terms for Lagrange's equations

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A generalization of that portion of the work of Berger, which deals with the long period coupling effect of certain pairs of zonal harmonics. Long period terms arising from the short short period coupling of zonal harmonics are derived for Lagrange's equations. The formulation is general so that the results are valid for any pairs of zonal harmonics. Formulas are given to generate the various functions and integrals needed for the results given. Checks have been made against the work of Kozai.

  16. 18 CFR 154.303 - Test periods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Test periods. 154.303... Changes § 154.303 Test periods. Statements A through M, O, P, and supporting schedules, in § 154.312 and § 154.313, must be based upon a test period. (a) If the natural gas company has been in operation for...

  17. 18 CFR 154.303 - Test periods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Test periods. 154.303... Changes § 154.303 Test periods. Statements A through M, O, P, and supporting schedules, in § 154.312 and § 154.313, must be based upon a test period. (a) If the natural gas company has been in operation for...

  18. Lightcurve and Rotation Period of 1044 Teutonia

    NASA Astrophysics Data System (ADS)

    Betzler, Alberto Silva; Ferreira, Diogo Henrique; Dos Santos, Tarcio Henrique Ribeiro; Novaes, Alberto Brum

    2008-03-01

    The minor planet 1044 Teutonia was observed 2007 June 8-9 UT, during 3.7h, in Salvador, Bahia, Brazil. The synodic period from the collected data are best fit by a period 2.84 ± 0.04 h and with an amplitude of 0.20 ± 0.03. However, the period of 3.153 ± 0.003 reported by Behrend et al. (2006) cannot be eliminated.

  19. Preparing to perform: periodization and dance.

    PubMed

    Wyon, Matthew

    2010-01-01

    This article reviews the historical and current literature on periodization in sport before applying the concept to dance from scientific and anecdotal points of view. Preparing the dancer through the use of a periodization model, in a professional or vocational setting, will potentially help prevent overtraining and its link to injury, while improving the dancer's readiness to perform optimally. Practical examples of tapering and periodization of training are discussed for companies and vocational schools.

  20. Coherent peculiar velocities and periodic redshifts

    SciTech Connect

    Hill, C.T.; Steinhardt, P.J.; Turner, M.S. Pennsylvania Univ., Philadelphia NASA/Fermilab Astrophysics Center, Batavia Chicago Univ., IL )

    1991-01-01

    A coherent, sinusoidal peculiar velocity field of 0.003 amplitude and wavelength of 128/h Mpc could explain the apparent redshift periodicity seen in the recent pencil-beam survey of Broadhurst et al. (1990). Such a peculiar velocity field could arise if the power spectrum of density perturbations has a strong feature at about this wavelength. This explanation has additional predictions: the phase, period, and strength of the periodicity should vary in different directions; the strength of the periodicity should decrease at higher redshifts; and there should be more thin structures perpendicular to the line of sight than parallel to it. 28 refs.

  1. NONPARAMETRIC BAYESIAN ESTIMATION OF PERIODIC LIGHT CURVES

    SciTech Connect

    Wang Yuyang; Khardon, Roni; Protopapas, Pavlos

    2012-09-01

    Many astronomical phenomena exhibit patterns that have periodic behavior. An important step when analyzing data from such processes is the problem of identifying the period: estimating the period of a periodic function based on noisy observations made at irregularly spaced time points. This problem is still a difficult challenge despite extensive study in different disciplines. This paper makes several contributions toward solving this problem. First, we present a nonparametric Bayesian model for period finding, based on Gaussian Processes (GPs), that does not make assumptions on the shape of the periodic function. As our experiments demonstrate, the new model leads to significantly better results in period estimation especially when the light curve does not exhibit sinusoidal shape. Second, we develop a new algorithm for parameter optimization for GP which is useful when the likelihood function is very sensitive to the parameters with numerous local minima, as in the case of period estimation. The algorithm combines gradient optimization with grid search and incorporates several mechanisms to overcome the high computational complexity of GP. Third, we develop a novel approach for using domain knowledge, in the form of a probabilistic generative model, and incorporate it into the period estimation algorithm. Experimental results validate our approach showing significant improvement over existing methods.

  2. Strange attractors and their periodic repetition.

    PubMed

    Wang, Qiudong; Oksasoglu, Ali

    2011-03-01

    In this paper, we present some important findings regarding a comprehensive characterization of dynamical behavior in the vicinity of two periodically perturbed homoclinic solutions. Using the Duffing system, we illustrate that the overall dynamical behavior of the system, including strange attractors, is organized in the form of an asymptotic invariant pattern as the magnitude of the applied periodic forcing approaches zero. Moreover, this invariant pattern repeats itself with a multiplicative period with respect to the magnitude of the forcing. This multiplicative period is an explicitly known function of the system parameters. The findings from the numerical experiments are shown to be in great agreement with the theoretical expectations. PMID:21456842

  3. 45 CFR 1336.51 - Project period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR NATIVE AMERICANS, NATIVE AMERICAN PROGRAMS NATIVE AMERICAN PROGRAMS Financial Assistance Provisions § 1336.51 Project period. The Notice...

  4. 7 CFR 1220.111 - Fiscal period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The...

  5. 7 CFR 1220.111 - Fiscal period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The...

  6. 7 CFR 1220.111 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The...

  7. 7 CFR 1220.111 - Fiscal period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The...

  8. 7 CFR 1220.111 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SOYBEAN PROMOTION, RESEARCH, AND CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The...

  9. Doppler effects on periodicities in Saturn's magnetosphere

    NASA Astrophysics Data System (ADS)

    Carbary, J. F.

    2015-11-01

    The magnetosphere of Saturn exhibits a wide variety of periodic phenomena in magnetic fields, charged particles, and radio emissions. The periodicities are observed from a moving spacecraft, so an issue arises about the periodicities being influenced by the Doppler effects. Doppler effects can be investigated using models of the periodicities and then flying the spacecraft through the model, effectively measuring any Doppler phenomena with the simulation. Using 200 days of typical elliptical orbits from the Cassini mission at Saturn, three models were tested: an azimuthal wave (or "searchlight") model, a radial wave (or "pond ripple") model, and a model of an outwardly traveling spiral wave. The azimuthal wave model produced virtually no Doppler effects in the periodicities because its wave vector is nearly perpendicular to the spacecraft trajectory. The radial wave model generated strong Doppler effects of an upshifted and a downshifted signal (a dual period) on either side of the true period, because the wave vector is either parallel or antiparallel to the spacecraft trajectory. Being intermediate to the searchlight and radial waves, the spiral wave produced Doppler effects but only for low wave speeds (<10 RS/h). For higher wave speeds the Doppler effects were not as clear. The Doppler effects can be mitigated by employing only observations beyond ~15 RS where the spacecraft speed is low compared to the wave speed. The observed periodicities over the same 200 day interval do not show evidence of Doppler effects but generally display a single feature at the expected ~10.7 h period.

  10. 7 CFR 1206.7 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.7 Fiscal period. Fiscal...

  11. 7 CFR 1206.7 - Fiscal period.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.7 Fiscal period. Fiscal...

  12. 7 CFR 1206.7 - Fiscal period.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.7 Fiscal period. Fiscal...

  13. 7 CFR 1206.7 - Fiscal period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.7 Fiscal period. Fiscal...

  14. 7 CFR 1206.7 - Fiscal period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.7 Fiscal period. Fiscal...

  15. Genetics Home Reference: tumor necrosis factor receptor-associated periodic syndrome

    MedlinePlus

    ... Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases. Joint Bone Spine. 2004 Jul;71(4):284-90. Review. Citation on PubMed Pettersson T, Kantonen J, Matikainen S, ...

  16. 10 CFR 35.2645 - Records of periodic spot-checks for gamma stereotactic radiosurgery units.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Records of periodic spot-checks for gamma stereotactic... MATERIAL Records § 35.2645 Records of periodic spot-checks for gamma stereotactic radiosurgery units. (a) A... and intercom systems, timer termination, treatment table retraction mechanism, and stereotactic...

  17. 10 CFR 35.645 - Periodic spot-checks for gamma stereotactic radiosurgery units.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Periodic spot-checks for gamma stereotactic radiosurgery... § 35.645 Periodic spot-checks for gamma stereotactic radiosurgery units. (a) A licensee authorized to... minimum— (1) Assure proper operation of— (i) Treatment table retraction mechanism, using backup...

  18. 76 FR 31349 - Determination of Regulatory Review Period for Purposes of Patent Extension; ACTEMRA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... treatment of rheumatoid arthritis. Subsequent to this approval, the Patent and Trademark Office received... HUMAN SERVICES Food and Drug Administration Determination of Regulatory Review Period for Purposes of... and Drug Administration (FDA) has determined the regulatory review period for ACTEMRA and...

  19. 10 CFR 35.2645 - Records of periodic spot-checks for gamma stereotactic radiosurgery units.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Records of periodic spot-checks for gamma stereotactic... MATERIAL Records § 35.2645 Records of periodic spot-checks for gamma stereotactic radiosurgery units. (a) A... and intercom systems, timer termination, treatment table retraction mechanism, and stereotactic...

  20. 10 CFR 35.2645 - Records of periodic spot-checks for gamma stereotactic radiosurgery units.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Records of periodic spot-checks for gamma stereotactic... MATERIAL Records § 35.2645 Records of periodic spot-checks for gamma stereotactic radiosurgery units. (a) A... and intercom systems, timer termination, treatment table retraction mechanism, and stereotactic...

  1. 12 CFR 516.270 - How long is the OTS review period?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false How long is the OTS review period? 516.270 Section 516.270 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES OTS Review Standard Treatment § 516.270 How long is the OTS review period? (a)...

  2. 12 CFR 516.270 - How long is the OTS review period?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false How long is the OTS review period? 516.270 Section 516.270 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES OTS Review Standard Treatment § 516.270 How long is the OTS review period? (a)...

  3. 12 CFR 116.270 - How long is the OCC review period?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false How long is the OCC review period? 116.270 Section 116.270 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES OCC Review Standard Treatment § 116.270 How long is the OCC review period? (a)...

  4. 12 CFR 516.270 - How long is the OTS review period?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true How long is the OTS review period? 516.270 Section 516.270 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES OTS Review Standard Treatment § 516.270 How long is the OTS review period? (a)...

  5. 20 CFR 404.321 - When a period of disability begins and ends.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  6. 20 CFR 404.321 - When a period of disability begins and ends.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  7. 20 CFR 404.321 - When a period of disability begins and ends.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  8. 20 CFR 404.321 - When a period of disability begins and ends.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  9. 20 CFR 404.321 - When a period of disability begins and ends.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... period described in § 404.1592a, the last month for which you received benefits. (d) When drug addiction... the number of entitlement periods you may have had based on disability where drug addiction or... are months in which treatment for your drug addiction or alcoholism is not available, months...

  10. 40 CFR 91.105 - Useful life period, recall, and warranty periods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Useful life period, recall, and... Standards and Certification Provisions § 91.105 Useful life period, recall, and warranty periods. (a) The useful life for PWC engines is a period of 350 hours of operation or 5 years of use, whichever...

  11. 40 CFR 91.105 - Useful life period, recall, and warranty periods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Useful life period, recall, and... Standards and Certification Provisions § 91.105 Useful life period, recall, and warranty periods. (a) The useful life for PWC engines is a period of 350 hours of operation or 5 years of use, whichever...

  12. 38 CFR 3.252 - Annual income; pension; Mexican border period and later war periods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Annual income; pension; Mexican border period and later war periods. 3.252 Section 3.252 Pensions, Bonuses, and Veterans' Relief... Dependency, Income and Estate § 3.252 Annual income; pension; Mexican border period and later war periods....

  13. 40 CFR 91.105 - Useful life period, recall, and warranty periods.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Useful life period, recall, and... Standards and Certification Provisions § 91.105 Useful life period, recall, and warranty periods. (a) The useful life for PWC engines is a period of 350 hours of operation or 5 years of use, whichever...

  14. 38 CFR 3.252 - Annual income; pension; Mexican border period and later war periods.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Annual income; pension; Mexican border period and later war periods. 3.252 Section 3.252 Pensions, Bonuses, and Veterans' Relief... Dependency, Income and Estate § 3.252 Annual income; pension; Mexican border period and later war periods....

  15. 38 CFR 3.252 - Annual income; pension; Mexican border period and later war periods.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Annual income; pension; Mexican border period and later war periods. 3.252 Section 3.252 Pensions, Bonuses, and Veterans' Relief... Dependency, Income and Estate § 3.252 Annual income; pension; Mexican border period and later war periods....

  16. 38 CFR 3.252 - Annual income; pension; Mexican border period and later war periods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Annual income; pension; Mexican border period and later war periods. 3.252 Section 3.252 Pensions, Bonuses, and Veterans' Relief... Dependency, Income and Estate § 3.252 Annual income; pension; Mexican border period and later war periods....

  17. 38 CFR 3.252 - Annual income; pension; Mexican border period and later war periods.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Annual income; pension; Mexican border period and later war periods. 3.252 Section 3.252 Pensions, Bonuses, and Veterans' Relief... Dependency, Income and Estate § 3.252 Annual income; pension; Mexican border period and later war periods....

  18. Donepezil Treatment of Older Adults with Cognitive Impairment and Depression (DOTCODE study): clinical rationale and design

    PubMed Central

    Pelton, Gregory H.; Andrews, Howard; Roose, Steven P.; Marcus, Sue M.; D’Antonio, Kristina; Husn, Hala; Petrella, Jeffrey R.; Zannas, Anthony S.; Doraiswamy, P. Murali; Devanand, D. P.

    2014-01-01

    Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depression (DOTCODE) pilot clinical trial. The DOTCODE study is the first long-term treatment trial that assesses differences in conversion to dementia and cognitive change in DEP-CI patients using a study design of open antidepressant medication plus add-on randomized, double-blind, placebo-controlled treatment with the acetylcholinesterase inhibitor donepezil. In Phase 1, DEP-CI patients receive optimized antidepressant treatment for 16 weeks. In Phase 2, antidepressant treatment is continued with the addition of randomized, double-blind treatment with donepezil or placebo. The total study duration for each patient is 78 weeks (18 months). Eighty DEP-CI outpatients (age 55 to 95 years) are recruited: 40 at New York State Psychiatric Institute/Columbia University and 40 at Duke University Medical Center. The primary outcome is conversion to a clinical diagnosis of dementia. The secondary outcomes are cognitive change scores in Selective Reminding Test (SRT) total recall and the modified Alzheimer’s Disease Assessment Scale (ADAS-cog). Other key assessments include the 24-item Hamilton Depression Rating Scale and antidepressant response; Clinical Global Impression (CGI) for depression, cognition, and global status; neuropsychological test battery for diagnosis; informant report of functional abilities (Pfeffer FAQ); Treatment Emergent Symptom Scale (TESS) for somatic side effects. Apolipoprotein E ε4 status, odor identification deficits, and MRI entorhinal/hippocampal cortex atrophy at baseline are evaluated as neurobiological moderators of donepezil treatment effects. PMID:24315979

  19. Co-treatment of Pitavastatin and Dexamethasone Exacerbates the High-fat Diet-induced Atherosclerosis in apoE-deficient Mice.

    PubMed

    Zhang, Wenwen; Wang, Xue; Hu, Wenquan; Liu, Lipei; Li, Xiaoju; Han, Jihong; Chen, Yuanli; Duan, Yajun

    2015-08-01

    Activation of macrophage adipocyte fatty acid-binding protein (FABP4) induces development of atherosclerosis in animal models. We previously reported that statin inhibited while dexamethasone activated macrophage FABP4 expression. However, co-treatment of macrophages with statin and dexamethasone induced FABP4 expression in a synergistic manner, which implies that this co-treatment may exacerbate high-fat diet (HFD)-induced atherosclerosis. In this study, we fed apoE-deficient (apoE) mice with HFD or HFD containing dexamethasone or pitavastatin or both for 16 weeks. Compared with HFD alone, pitavastatin or dexamethasone had little effect on lesions in both en face aortas and aortic root cross sections. However, the co-treatment exacerbated HFD-induced lesions. In addition, the co-treatment decreased collagen content and disturbed the integrity of lesion caps. Both serum total cholesterol and LDL cholesterol levels were reduced by pitavastatin and increased by dexamethasone, respectively. However, the co-treatment had little effect on both total cholesterol and LDL cholesterol levels, indicating that the exacerbation of lesions is independent of total cholesterol or LDL cholesterol levels. FABP4 expression in aortic lesion area was significantly induced by the co-treatment, suggesting that activation of FABP4 expression is a main contributor to lesions. In conclusion, our study demonstrates that co-treatment of pitavastatin and dexamethasone exacerbates HFD-induced atherosclerosis and defines a potential risk to use the dual treatment for patients in clinics.

  20. Treatment Outcome in Male Gambling Disorder Patients Associated with Alcohol Use

    PubMed Central

    Jiménez-Murcia, Susana; Del Pino-Gutiérrez, Amparo; Fernández-Aranda, Fernando; Granero, Roser; Hakänsson, Anders; Tárrega, Salomé; Valdepérez, Ana; Aymamí, Neus; Gómez-Peña, Mónica; Moragas, Laura; Baño, Marta; Sauvaget, Anne; Romeu, Maria; Steward, Trevor; Menchón, José M.

    2016-01-01

    Aims: The primary objective of this study was to analyze the association between alcohol consumption and short-term response to treatment (post intervention) in male patients with gambling disorder enrolled in a group cognitive behavioral therapy (CBT) program. Methods: The sample consisted of 111 male individuals with a diagnosis of Gambling Disorder, with a mean age of 45 years (SD = 12.2). All participants were evaluated by a comprehensive assessment battery and assigned to CBT groups of 10–14 patients attending 16 weekly outpatient sessions lasting 90 min each. Results: The highest mean pre- and post-therapy differences were recorded for the alcohol risk/dependence group on the obsessive/compulsive and anxiety dimensions of the SCL-90-R. As regards the presence of relapses and dropouts over the course of the CBT sessions, the results show a significant association with moderate effect size: patients with risk consumption or alcohol dependence were more likely to present poor treatment outcomes. Conclusions: Alcohol abuse was frequent in GD, especially in patients with low family income and high accumulated debts. High levels of somatization and high overall psychopathology (measured by the SCL-90-R) were associated with increased risk of alcohol abuse. Alcohol abuse was also associated with poor response to treatment. PMID:27065113