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Sample records for 17th world computer

  1. 17th World Food Day observed.

    PubMed

    1997-01-01

    The UN Food and Agriculture Organization has dubbed October 16 World Food Day in an effort to create awareness and generate interest in the efforts being made to alleviate hunger and malnutrition, and to increase food production. A flag-raising ceremony marked the 17th World Food Day, on investing in food security, in Accra, Ghana. The Vice-President of Ghana noted at the ceremony that his government has made agriculture its top priority and is determined to invest as much as needed to achieve significant growth in the sector. The government is also taking steps to make agriculture so attractive that both private individuals and companies will find it a profitable sector in which to partake. The government of Ghana will provide its fullest cooperation and support in all technical and logistical aspects of the production process to prospective investors in the sector. Enlightened government policies are needed to ensure a broader framework for improving food security through agricultural development.

  2. 17th Edition of TOP500 List of World's Fastest SupercomputersReseased

    SciTech Connect

    Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack J.; Simon,Horst D.

    2001-06-21

    17th Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, GERMANY; KNOXVILLE, TENN.; BERKELEY, CALIF. In what has become a much-anticipated event in the world of high-performance computing, the 17th edition of the TOP500 list of the world's fastest supercomputers was released today (June 21). The latest edition of the twice-yearly ranking finds IBM as the leader in the field, with 40 percent in terms of installed systems and 43 percent in terms of total performance of all the installed systems. In second place in terms of installed systems is Sun Microsystems with 16 percent, while Cray Inc. retained second place in terms of performance (13 percent). SGI Inc. was third both with respect to systems with 63 (12.6 percent) and performance (10.2 percent).

  3. Computers in Libraries Annual Conference (17th, Washington, DC, March 13-15, 2002): Collected Presentations.

    ERIC Educational Resources Information Center

    Nixon, Carol, Comp.

    This book contains presentations from the 17th annual Computers in Libraries Conference. Topics covered include: chatting with a librarian; verbots for library Web sites; collaborative IT (Information Technology) planning at Montgomery County Public Library (Maryland); designing a local government taxonomy; Weblogs; new roles for librarians in…

  4. Computers in Libraries Annual Conference (17th, Washington, DC, March 13-15, 2002): Collected Presentations.

    ERIC Educational Resources Information Center

    Nixon, Carol, Comp.

    This book contains presentations from the 17th annual Computers in Libraries Conference. Topics covered include: chatting with a librarian; verbots for library Web sites; collaborative IT (Information Technology) planning at Montgomery County Public Library (Maryland); designing a local government taxonomy; Weblogs; new roles for librarians in…

  5. Invitation to the 17th international congress on photosynthesis research in 2016: photosynthesis in a changing world.

    PubMed

    van Amerongen, Herbert; Croce, Roberta

    2016-02-01

    The 17th International Congress on Photosynthesis will be held from August 7 to 12, 2016 in Maastricht, The Netherlands. The congress will include an opening reception, 15 plenary lectures, 28 scientific symposia, many poster sessions, displays by scientific companies, excursions, congress dinner, social activities, and the first photosynthesis soccer world championship. See http://www.ps2016.com/ . The congress is organized as an official event of the International Society of Photosynthesis Research (see http://www.photosynthesisresearch.org/).

  6. Anatomical confirmation of computed tomography-based diagnosis of the atherosclerosis discovered in 17th century Korean mummy.

    PubMed

    Kim, Myeung Ju; Kim, Yi-Suk; Oh, Chang Seok; Go, Jai-Hyang; Lee, In Sun; Park, Won-Kyu; Cho, Seok-Min; Kim, Soon-Kwan; Shin, Dong Hoon

    2015-01-01

    In the present study on a newly discovered 17th century Korean mummy, computed tomography (CT) revealed multiple aortic calcifications within the aortic wall that were indicative of ancient atherosclerosis. The CT-based findings were confirmed by our subsequent post-factum dissection, which exhibited possible signs of the disease including ulcerated plaques, ruptured hemorrhages, and intimal thickening where the necrotic core was covered by the fibrous cap. These findings are strong indicators that the mummy suffered from aortic atherosclerosis during her lifetime. The present study is a good example of how CT images of vascular calcifications can be a useful diagnostic tool in forming at least preliminary diagnoses of ancient atherosclerosis.

  7. Anatomical Confirmation of Computed Tomography-Based Diagnosis of the Atherosclerosis Discovered in 17th Century Korean Mummy

    PubMed Central

    Kim, Myeung Ju; Kim, Yi-Suk; Oh, Chang Seok; Go, Jai-Hyang; Lee, In Sun; Park, Won-Kyu; Cho, Seok-Min; Kim, Soon-Kwan; Shin, Dong Hoon

    2015-01-01

    In the present study on a newly discovered 17th century Korean mummy, computed tomography (CT) revealed multiple aortic calcifications within the aortic wall that were indicative of ancient atherosclerosis. The CT-based findings were confirmed by our subsequent post-factum dissection, which exhibited possible signs of the disease including ulcerated plaques, ruptured hemorrhages, and intimal thickening where the necrotic core was covered by the fibrous cap. These findings are strong indicators that the mummy suffered from aortic atherosclerosis during her lifetime. The present study is a good example of how CT images of vascular calcifications can be a useful diagnostic tool in forming at least preliminary diagnoses of ancient atherosclerosis. PMID:25816014

  8. Scientific Misconduct and Theft: Case Report from 17th Century

    PubMed Central

    Fatović-Ferenčić, Stella

    2008-01-01

    Gjuro Armen Baglivi was one of the most famous medical authorities of the 17th century. Apart from his numerous books and publications, several extensive collections of his correspondence have been preserved and are available in libraries around the world. They provide new information about the 17th century scientific culture and place of Baglivi’s work in the scientific European context. Also, they shed light on his personality more than other writings intended for the public eye. In this paper I will present the case of a theft of intellectual property, which Baglivi described in one of his letters to Jean Jacques Manget. PMID:18293461

  9. Proceedings of The 1980 Army Numerical Analysis and Computers Conference (17th) Held at Moffett Field, California on 20-21 February 1980.

    DTIC Science & Technology

    1980-08-01

    137 APPROXIMATIONS FOR Z [G(s) F(s)] Richard E. Dickson ........ ...................... ... 147 RADIX 65/39, A ROOT...APPROXIMATIONS FOR Z (G(s) F(s)) Dr. Richard E. Dickson, US Army Missile Command, Redstone Arsenal, Alabama RADIX 65/39, A ROOT SEARCHING ALGORITHM FOR...III CHAIRPERSON - Dr. Billy Z . Jenkins, US Army Missile Command, Redstone Arsenal, Alabama COMPUTATIONAL TRANSONICS ON A VECTOR COMPUTER Messrs. Jerry S

  10. Proceedings of the Symposium on the Interface of Computer Science and Statistics (17th) Held in Lexington, Kentucky on 17-19 March 1985.

    DTIC Science & Technology

    1986-03-04

    experience of some thousands of users, S satisfies this goal quite The personal effects of the networking environment well. However, in order for...of small reflect the necessary involvement of computer solutions to both scientific machinery to effect the desired and general administrative...which are portability of statistical computing much more expensive than the via a central database of data, packet-switched data networks . programs and

  11. Harvard Humanities Students Discover the 17th Century Online

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university…

  12. Harvard Humanities Students Discover the 17th Century Online

    ERIC Educational Resources Information Center

    Howard, Jennifer

    2007-01-01

    This article profiles Harvard professor Stephen Greenblatt's new course, "Travel and Transformation in the Early 17th Century." The product of an intense, months-long collaboration between computing specialists, graduate students, librarians, and scholars, the course makes innovative use of all the tools and technical know-how a major university…

  13. Virtual Worlds in Computing Education

    ERIC Educational Resources Information Center

    Crellin, Jonathan; Duke-Williams, Emma; Chandler, Jane; Collinson, Timothy

    2009-01-01

    This article reports on the use of a virtual world ("Second Life") in computing education, and identifies the precursors of current virtual world systems. The article reviews the potential for virtual worlds as tools in computing education. It describes two areas where "Second Life" has been used in computing education: as a…

  14. 17th Annual School Construction Report, 2012

    ERIC Educational Resources Information Center

    Abramson, Paul

    2012-01-01

    The 2012 "School Planning & Management"'s 17th Annual School Construction Report reports over the last two years although school construction had fallen from previous highs, the pipeline of projects funded before the recession was still full. And so, in 2009 total construction was a solid $16.4 billion. But the pipeline is not being…

  15. 17th Annual School Construction Report, 2012

    ERIC Educational Resources Information Center

    Abramson, Paul

    2012-01-01

    The 2012 "School Planning & Management"'s 17th Annual School Construction Report reports over the last two years although school construction had fallen from previous highs, the pipeline of projects funded before the recession was still full. And so, in 2009 total construction was a solid $16.4 billion. But the pipeline is not being…

  16. 17th International Conference on Arabidopsis Research

    SciTech Connect

    Bender, Judith

    2006-07-02

    The 17th International Conference on Arabidopsis Research was held at the University of Madison, Wisconsin from June 27- July 2, 2006. ICAR-2006 included approximately 625 scientists from across the world. The scientific program was of excellent quality featuring 73 talks, including 30 from invited speakers. There were also 6 community-organized workshops (facilitated by conference staff) featuring additional talks on topics including ‘Submitting data to long-term repositories,’ ‘TAIR introductory workshop,’ ‘Web services and demonstration,’ ‘Public engagement: broadening the impact of your research,’ ‘Systems biology approaches to analysis of metabolic and regulatory networks of Arabidopsis,’ and ‘Mechanotransduction in Arabidopsis.’ Approximately 440 posters were presented in general topic areas including, among others, Development, Modeling/Other Systems, Energy, Environment, and Genetic/Epigenetic mechanisms. Graduate students, postdoctoral researchers, junior faculty, and underrepresented minorities made up a significant portion of the oral presentations thereby promoting the training of young scientists and facilitating important career development opportunities for speakers. Several poster sessions provided an opportunity for younger participants to freely meet with more established scientists. The North American Arabidopsis Steering Committee (NAASC) continued its outreach effort and again sponsored two special luncheons to encourage personal and professional development of young scientists and also underrepresented minorities. The ‘Emerging Scientists Luncheon’ featured 10 graduate students selected on the basis of scientific excellence of their submitted research abstracts. The ‘Minority Funding Luncheon,’ featured 8 awardees selected by the NAASC through a widely-publicized application process. This luncheon was established specifically to provide an opportunity for underrepresented minorities, and/or scientists from

  17. The Computing World

    DTIC Science & Technology

    1992-04-01

    to modern computers. In the 1840s Augusta Ada, the Countess of Lovelace, translated and wrote several scientific papers regarding Charles P...Babbage’s ideas on an analytical engine problem solving machine. 3 Babbage , "the father of computers," developed ways to store results via memory devices. Ada...simple arithmetic calculating machines to small complex and powerful integrated circuit computers. Jacquard, Babbage and Lovelace set the computer

  18. DIMMING OF THE 17TH CENTURY SUN

    SciTech Connect

    Foukal, Peter; Ortiz, Ada; Schnerr, Roald

    2011-06-01

    Reconstructions of total solar irradiance (TSI) rely mainly on linear relations between TSI variation and indices of facular area. When these are extrapolated to the prolonged 15th-17th century Spoerer and Maunder solar activity minima, the estimated solar dimming is insufficient to explain the mid-millennial climate cooling of the Little Ice Age. We draw attention here to evidence that the relation departs from linearity at the lowest activity levels. Imaging photometry and radiometry indicate an increased TSI contribution per unit area from small network faculae by a factor of 2-4 compared with larger faculae in and around active regions. Even partial removal of this more TSI-effective network at prolonged minima could enable climatically significant solar dimming, yet be consistent with the weakened but persistent 11 yr cycle observed in Be 10 during the Maunder Minimum. The mechanism we suggest would not alter previous findings that increased solar radiative forcing is insufficient to account for 20th century global warming.

  19. 17th Space Photovoltaic Research and Technology Conference

    NASA Technical Reports Server (NTRS)

    Jenkins, Phillip (Compiler)

    2002-01-01

    The 17th Space Photovoltaic Research and Technology (SPRAT XVII) Conference was held September 11-13, 2001, at the Ohio Aerospace Institute (OAI) in Cleveland, Ohio. The SPRAT conference, hosted by the Photovoltaic and Space Environments Branch of the NASA Glenn Research Center, brought together representatives of the space photovoltaic community from around the world to share the latest advances in space solar technology. This year's conference continued to build on many of the trends shown in SPRAT XVI; the use of new high-efficiency cells for commercial use and the development of novel array concepts such as Boeing's Solar Tile concept. In addition, new information was presented on space environmental interactions with solar arrays.

  20. Student Generated Section, Course and Alternate Requests as the Keystone of a Computer Based, Student Responsive, Advance Registration and Scheduling System. College and University Machine Records Annual Conference. (17th, Columbus, Ohio, May 1972.)

    ERIC Educational Resources Information Center

    Overturf, Leonard O.; Fastman, Jerry

    This document describes a system of computerized advance registration at Colorado State University. The main objective is to generate a schedule that will satisfy student requests and needs, given constraints of faculty, time, and space. The system consists of a series of computer programs and a set of well-documented manual procedures in the…

  1. [Discovery of blood cells in the 17th century].

    PubMed

    Doubek, M

    2001-07-01

    Landmark works of the 17th century concerning observations of blood cells are quoted in the article. "Simple" and successively "compound" microscopes made their appearance in the late 16th century and early 17th century. In 1656, Frenchman Pierre Borel, physician-in-ordinary to the King Louis XIV, who first applied the microscope to medicine described a type of "worn" found in human blood. In 1657, Athanasius Kircher, a Jesuit priest and scientist from Germany, examined blood from plague victims, and described "worms" of plague. In 1661, 1664 and 1665, the blood cells were discerned by Marcello Malpighi. In 1678, the red blood corpuscles was described by Jan Swammerdam of Amsterdam, a Dutch naturalist and physician. The first complete account of the red cells was made by Anthony van Leeuwenhoek of Delft in the last quarter of the 17th century.

  2. High Life: 17th Annual Residence Hall Construction Report

    ERIC Educational Resources Information Center

    Agron, Joe

    2006-01-01

    Residence hall construction continues to be a priority for colleges and universities. With enrollments on the upswing, higher-education institutions are spending more and building larger facilities to entice students to live on campus. This article presents the findings of "American School & University's" 17th annual Residence Hall Construction…

  3. High Life: 17th Annual Residence Hall Construction Report

    ERIC Educational Resources Information Center

    Agron, Joe

    2006-01-01

    Residence hall construction continues to be a priority for colleges and universities. With enrollments on the upswing, higher-education institutions are spending more and building larger facilities to entice students to live on campus. This article presents the findings of "American School & University's" 17th annual Residence Hall Construction…

  4. Jaguar: The World?s Most Powerful Computer

    SciTech Connect

    Bland, Arthur S Buddy; Rogers, James H; Kendall, Ricky A; Kothe, Douglas B; Shipman, Galen M

    2009-01-01

    The Cray XT system at ORNL is the world s most powerful computer with several applications exceeding one-petaflops performance. This paper describes the architecture of Jaguar with combined XT4 and XT5 nodes along with an external Lustre file system and external login nodes. We also present some early results from Jaguar.

  5. Pigment characterization of important golden age panel paintings of the 17th century

    NASA Astrophysics Data System (ADS)

    Pięta, Ewa; Proniewicz, Edyta; Szmelter-Fausek, Bożena; Olszewska-Świetlik, Justyna; Proniewicz, Leonard M.

    2015-02-01

    Samples were obtained from two world-famous 17th century panel paintings of the Gdańsk school of panting: 'Seven Acts of Charity' (1607, in St. Mary's Church in Gdańsk, Poland) by Anton Möller and 'Angelic Concert' (1611, in Diocesan Museum in Pelplin, Poland) by Hermann Han. Micro-Raman spectroscopy (MRS), optical microscopy (OM), and X-ray fluorescence (XRF) spectroscopy studies of the samples were performed to characterize the pigments present in the individual painting layers (a rich palette of white, black, blue, red, and yellow pigments) and the pictorial techniques used by the artists.

  6. [Rules of hygiene and moral guidance in medical practice, 16th-17th centuries Spain].

    PubMed

    Ruiz Somavilla, María José

    2002-01-01

    In recent decades, we have seen how members of the illiterate, popular classes gained access to specific contents of elite culture by means of oral expression collected through texts. This development may be related to the target readership of medical texts published in Spain during the 16th and 17th centuries. The study also analyses how information about preventive measures in health care was passed on through medical books from professionals to lay-people. This represents one of the key methods used by medical practice in the modern world.

  7. Report from 17th Hydrology Days Conference available

    NASA Astrophysics Data System (ADS)

    The 17th annual Hydrology Days Conference was held from April 14-18,1997, at Colorado State University in Fort Collins. Highlights of the meeting included awards for the best student papers, given to Lyn Benjamin and Kevin Williams, both of Utah State University, and to Tom Sale of Colorado State University and Frank Barranco of the Colorado School of Mines. Proceedings from the meeting are available for $30 from H. J. Morel-Seytoux (57 Selby Lane, Atherton, CA 94027-3926 USA; tel. +1-415-365-4080semi; e-mail morelsey@usgs.gov)

  8. Anatomy and anatomists in Tuscany in the 17th century.

    PubMed

    Orlandini, Giovanni E; Paternostro, Ferdinando

    2010-01-01

    The 17th century was characterized by a real revolution in the field of scientific research due to the introduction of the experimental method, promoted by Galileo Galilei who was the most representative scientist of this period. Therefore, medical disciplines, particularly Anatomy, underwent innovative and deep changes shattering traditional culture and representing the background for the modern science. In this fermenting period, Tuscany played a significant role since numerous distinguished scientists were gathered by Medici Grand Dukes (especially Ferdinando the 2nd and Cosimo the 3rd) at Pisa University and at their court in Florence. Among them, it must be mentioned Giovanni Alfonso Borelli, creator of iathromechanics, Marcello Malpighi, founder of microscopic Anatomy, Francesco Redi, who denied the insect spontaneous generation, Nils Steensen who continued in Florence his anatomical studies on lymph nodes and salivary glands while setting also the bases of modern geology. Moreover, at the end of the 17th century, the anatomical wax modelling techniques arose and developed in Florence thanks to the work of Gaetano Zumbo (or Zummo), capable of creating some real masterpieces, still very well preserved and collected in the Museum of Natural Sciences "La Specola".

  9. In the sign of Galileo: pictorial representation in the 17th-century Copernican debate.

    PubMed

    Remmert, Volker R

    2003-03-01

    After Galileo had discovered the four moons of Jupiter in 1609 he became increasingly convinced that the Copernican, heliocentric system of the world was correct. However, this ran against the opinions of the Church and a large number of contemporary astronomers and natural philosophers. The ensuing development culminated in the condemnation of the Copernican system by the Church in 1616 and of Galileo himself, who had propagated the Copernican system in his Dialogue Concerning the Two Chief World Systems (1632), in 1633. Nevertheless, there was a constant debate about the right world system during the whole 17th century. Pictorial representation played an important role in it and the illustrations used as book frontispieces were a significant medium for the dispute.

  10. Laptop Computers for Third World Students

    ERIC Educational Resources Information Center

    Pierce, Alan

    2008-01-01

    The nonprofit organization One Laptop per Child (OLPC) has a mission that is easy to articulate but very challenging to achieve: Provide laptop computers to the almost 2 billion children who live in parts of the world where poverty and the lack of a structured educational system deprive them of an adequate education. To further complicate the…

  11. Laptop Computers for Third World Students

    ERIC Educational Resources Information Center

    Pierce, Alan

    2008-01-01

    The nonprofit organization One Laptop per Child (OLPC) has a mission that is easy to articulate but very challenging to achieve: Provide laptop computers to the almost 2 billion children who live in parts of the world where poverty and the lack of a structured educational system deprive them of an adequate education. To further complicate the…

  12. Anomalous solar rotation in the early 17th century.

    PubMed

    Eddy, J A; Gilman, P A; Trotter, D E

    1977-11-25

    The character of solar rotation has been examined for two periods in the early 17th century for which detailed sunspot drawings are available: A.D. 1625 through 1626 and 1642 through 1644. The first period occurred 20 years before the start of the Maunder sunspot minimum, 1645 through 1715; the second occurred just at its commencement. Solar rotation in the earlier period was much like that of today. In the later period, the equatorial velocity of the sun was faster by 3 to 5 percent and the differential rotation was enhanced by a factor of 3. The equatorial acceleration with declining solar activity is in the same sense as that found in recent Doppler data. It seems likely that the change in rotation of the solar surface between 1625 and 1645 was associated with the onset of the Maunder Minimum.

  13. JANNAF 17th Propulsion Systems Hazards Subcommittee Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    Volume 1, the first of two volumes is a compilation of 16 unclassified/unlimited technical papers presented at the 17th meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Propulsion Systems Hazards Subcommittee (PSHS) held jointly with the 35th Combustion Subcommittee (CS) and Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7 - 11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include projectile and shaped charge jet impact vulnerability of munitions; thermal decomposition and cookoff behavior of energetic materials; damage and hot spot initiation mechanisms with energetic materials; detonation phenomena of solid energetic materials; and hazard classification, insensitive munitions, and propulsion systems safety.

  14. JANNAF 17th Propulsion Systems Hazards Subcommittee Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Gannaway, Mary T. (Editor); Rognan, Melanie (Editor)

    1998-01-01

    Volume 1, the first of two volumes is a compilation of 16 unclassified/unlimited technical papers presented at the 17th meeting of the Joint Army-Navy-NASA-Air Force (JANNAF) Propulsion Systems Hazards Subcommittee (PSHS) held jointly with the 35th Combustion Subcommittee (CS) and Airbreathing Propulsion Subcommittee (APS). The meeting was held on 7 - 11 December 1998 at Raytheon Systems Company and the Marriott Hotel, Tucson, AZ. Topics covered include projectile and shaped charge jet impact vulnerability of munitions; thermal decomposition and cookoff behavior of energetic materials; damage and hot spot initiation mechanisms with energetic materials; detonation phenomena of solid energetic materials; and hazard classification, insensitive munitions, and propulsion systems safety.

  15. [Surgeons among the pirates in the 17th century].

    PubMed

    Snelders, S

    2005-12-24

    The memoirs of ship's surgeons that sailed with the Caribbean buccaneers and pirates of the 17th century are an important source of information on how they lived and worked. The surgeons enjoyed a full-fledged position among the egalitarian buccaneers. Known buccaneer surgeons whose memoirs have been preserved were apparently not entirely qualified according to the traditional guild system. Besides the usual work of ship's surgeons in general, the buccaneer surgeons had to be able to cope with the specific demands of the tropical climate. Botanical knowledge obtained from the Indian tribes played an important role in surviving the jungles of Central America. In addition, they were required to assist with duels, which played an important role among pirates and buccaneers in the settling of conflicts aboard ship, this in contrast to the situation on merchant and navy ships.

  16. EDITORIAL The 17th Central European Workshop on Quantum Optics

    NASA Astrophysics Data System (ADS)

    Man'ko, Margarita A.

    2011-02-01

    . The uncertainty relations for photon quadratures were also checked for the thermal photon state using experimental values of optical tomograms and avoiding the reconstruction procedure of the Wigner function and its associated precision constrains. In the tomographic-probability representation of quantum mechanics and quantum optics, tomograms are used for the description of quantum states as an alternative to the wave function and density matrix. The purity, fidelity, entropy and photon temperature associated with quantum states are expressed in terms of tomograms. This provides the possibility of measuring these characteristics directly by taking optical tomograms and checking basic inequalities like entropic uncertainty relations, temperature-dependent quadrature uncertainty relations, etc. The better understanding that quantum states can be identified with measurable probability distributions like optical tomograms opens new prospects in quantum optics, for example, to check experimentally the uncertainty relations for higher quadrature momenta and to control the precision with which the fundamental inequalities of quantum mechanics are experimentally confirmed. This Topical Issue is a collection of papers presented at the 17th Central European Workshops on Quantum Optics (CEWQO10) held at the University of St Andrews, Scotland, UK, 6-11 June 2010. The other collaborators from different scientific centers who could not, due to different reasons, come to St Andrews but participated in the previous CEWQOs and plan to participate in future CEWQOs also contributed to this issue. The paper by Ulf Leonhardt and Natalia Korolkova, the CEWQO10 Organizers, opens this issue. The order of the following papers corresponds to the alphabetical order of the first author of the paper. The history of CEWQOs can be found in the Preface to the Proceedings of the 15th CEWQO (2009 Phys. Scr. T135 011005). The Proceedings of the 16th Central European Workshop on Quantum Optics (CEWQO09

  17. The 17th International Conference on Antiviral Research.

    PubMed

    Buckheit, Robert W

    2004-09-01

    The focus of the 17th International Conference on Antiviral Research was the discovery and development of antiviral agents (chemistry, biology, animal models and clinical trial results) against a variety of human infectious agents including HIV, herpes viruses, hepatitis viruses, respiratory viruses and emerging/re-emerging pathogens. The meeting included the symposium 'Clinical Update on Antiviral Drugs', plenary sessions dedicated to each of the individual classes of infectious agents, a symposium on new developments surrounding emerging pathogens, and three special award lectures, which discussed the history of nucleotide antiviral agents, mechanisms of viral persistence and drug resistance, and the therapy of herpes virus infections. Within each infectious agent session the presentations included those describing the development of new and novel anti-infectives, including research based on the preclinical development of new molecules, and the results of animal modelling and clinical studies on advanced-stage antiviral agents. A summary of the meeting highlights, segregated by infectious agent, will be presented in this review.

  18. Nostalgia in the Army (17th-19th Centuries).

    PubMed

    Battesti, Michèle

    2016-01-01

    People died from nostalgia in the army in the 17th-19th centuries. The term 'nostalgia', created by the doctor Johannes Hofer (1669-1752), from Mulhouse, came from the Germanic Heimweh, or 'homesickness'. It affected the young people enrolled in the army, such as Swiss mercenaries. Longing for their native land, they were consumed by an ongoing desire to return home. If it was impossible to do so, they sank into 'a sadness accompanied with insomnia, anorexia and other unpleasant symptoms' that could lead to death. Nostalgia became classified as a disease during the last quarter of the 18th century and ravaged the French army during the Revolution and the Napoleonic wars. However, as soon as the wars ended, it ceased to exist in the army (except the colonial army). It was removed from the nosology in the first half of the 19th century. Rapidly explained as an example of a misdiagnosis or a confusion between 'connection and cause', nostalgia needs to be assessed in regard to the medical debate between 'alienists' and 'organicists'. Creating much concern, nostalgia needs to be considered in the historical context of a society destabilized by modernity, with some individuals uprooted by the sudden transition from civil society to military life. It raises questions about the role that the army played in the creation of the French national union. Nostalgia may have also covered psychic traumatisms later designated as combat fatigue, war neurosis, or post-traumatic stress disorder. © 2016 S. Karger AG, Basel.

  19. A Mediterranean derecho: Catalonia (Spain), 17th August 2003

    NASA Astrophysics Data System (ADS)

    López, J. Manuel

    2007-02-01

    At approximately 6:10 UTC in the morning of 17th August 2003, a squall line developed over south Catalonia (the northeast region of Spain). During the next 9 h, the squall moved rapidly northeast and crossed Catalonia and the French regions of Languedoc-Roussillon and Province, damaging and uprooting hundreds of trees and blocking trains in the region. Wind gusts reached were recoded up to 52 m/s with evidence of F2 intensity damage. This case study shows the characteristics of a derecho (widespread convectively induced windstorm). Radar observations of the evolving squall line show signatures often correlated with damaging surface winds, including: Bow echoes, Rear inflow notches, Rear inflow jets, Medium altitude radial convergence, Narrow gradient of very marked reflectivity, Development of isolated cells ahead of the convective line, A band of convection off the northern end of the line known as a "warm advection wing". When examining the different surface observations, satellite, radar imagery and cloud-to-ground lightning data, this case shows many similarities to those investigated in the United States. The derecho is a hybrid case, but has many characteristics of warm season derechoes. This emanates from a mesoscale convective complex (MCC) moving along a quasi-stationary, low-level thermal boundary in an environment characterized by high potential instability and relatively strong mid-tropospheric winds.

  20. 17th Floor: A pedagogical oracle from/with Audre Lorde.

    PubMed

    Gumbs, Alexis Pauline

    2016-10-10

    In 1974, warrior poet mother Audre Lorde published the poem "Blackstudies," a freeform dream villanelle about her complicated experience as a Black lesbian feminist English professor at the City University of New York during the dynamic period when students rose up in protest. The university granted open admissions, and cultural nationalists who taught at City University worked to create a Black Studies program. In the poem, she describes her vantage point at this particular historical and pedagogical moment from the seventeenth floor within a dreamscape where she navigates the stereotypes, silences, and urgencies that shaped her experience as an educator. 17(th) Floor is a poetic oracle that contextualizes the ongoing work of "Blackstudies" (the poem and the practice), and for this reason, it should be activated as a resource for current Black and Brown lesbian educators and everyone who brings complexity and nuance to their teaching settings, their students, each other, and the world more broadly.

  1. Computers in the World of College English.

    ERIC Educational Resources Information Center

    Tannheimer, Charlotte

    This sabbatical report surveys some computer software presently being developed, already in use, and/or available, and describes computer use in several Massachusetts colleges. A general introduction to computers, word processors, artificial intelligence, and computer assisted instruction is provided, as well as a discussion of what computers can…

  2. Computers in the World of College English.

    ERIC Educational Resources Information Center

    Tannheimer, Charlotte

    This sabbatical report surveys some computer software presently being developed, already in use, and/or available, and describes computer use in several Massachusetts colleges. A general introduction to computers, word processors, artificial intelligence, and computer assisted instruction is provided, as well as a discussion of what computers can…

  3. Otto von Guericke and 17th century cosmology

    NASA Astrophysics Data System (ADS)

    Knobloch, Eberhard

    Otto von Guericke's scientific method was based on reason and experimental science. His cosmology was embedded in theology and can be interpreted as a refutation of Descartes' worldview. He used Nicolaus Cusanus' theory of quantities in order to characterize space. The notion of space has to be distinguished from that of world or heaven. Forces play a crucial role in this respect described by Athanasius Kircher in his "Celestial Journey". Guericke read this work very diligently. In spite of some obvious similarities between Guericke's and Newton's scientific aims and methods there are crucial differences between the scientific convictions and results of these scholars.

  4. Girls Save the World through Computer Science

    ERIC Educational Resources Information Center

    Murakami, Christine

    2011-01-01

    It's no secret that fewer and fewer women are entering computer science fields. Attracting high school girls to computer science is only part of the solution. Retaining them while they are in higher education or the workforce is also a challenge. To solve this, there is a need to show girls that computer science is a wide-open field that offers…

  5. Radiological Diagnosis of Congenital Diaphragmatic Hernia in 17th Century Korean Mummy

    PubMed Central

    Kim, Yi-Suk; Lee, In Sun; Jung, Go-Un; Kim, Myeung Ju; Oh, Chang Seok; Yoo, Dong Su; Lee, Won-Joon; Lee, Eunju; Cha, Soon Chul; Shin, Dong Hoon

    2014-01-01

    Congenital diaphragmatic hernia (CDH) is a birth defect of the diaphragm resulting in pulmonary sequelae that threaten the lives of infants. In computed tomography (CT) images of a 17th century middle-aged male mummy (the Andong mummy), we observed that the abdominal contents had protruded into the right thoracic cavity through the diaphragmatic defect, accompanied by a mediastinal shift to the left. On autopsy, the defect in the right posterolateral aspect of the diaphragm was reconfirmed, as was the herniation of the abdominal organs. The herniated contents included the right lobe of the liver, the pyloric part of the stomach, a part of the greater omentum, and the right colic flexure connecting the superior part of the ascending colon and the right part of the transverse colon. Taking our CT and autopsy results together, this case was diagnosed as the Bochdalek-type CDH. Herein we make the first ever report of a CT-assisted diagnosis of a pre-modern historical case of CDH. Our results show the promising utility of this modality in investigations of mummified human remains archaeologically obtained. PMID:24988465

  6. The Different World of Television and Computers.

    ERIC Educational Resources Information Center

    Commager, Henry Steele

    1982-01-01

    The impact of television on mass culture and of computer technology on research in the social sciences and humanities is discussed. Questions are raised concerning the quality of research based on information available from computers. It is suggested that "a super-abundance of information is no substitute for wisdom." (PP)

  7. Computer Training for the Real World.

    ERIC Educational Resources Information Center

    American School and University, 1981

    1981-01-01

    Hull High School in suburban Boston (Massachusetts) is rated as one of the top 10 secondary schools in the country offering a computer education program. The same computers used by the students are shared by school officials for administrative tasks. (Author/MLF)

  8. Report on the 17th Annual Land O'Lakes Bioanalytical Conference.

    PubMed

    Burns, Erik C; Moran, Jeff; Breidinger, Sheila; Ho, Stacy; Guthrie, Randy; Amaravardi, Lakshmi

    2016-11-01

    17th Annual Land O'Lakes Bioanalytical Conference, Madison, WI, USA, 11-14 July 2016 The 17th Annual Land O'Lakes Bioanalytical Conference, titled 'Biomarker Validation, Stability, and Regulatory Concerns', was held on 11-14 July 2016 (Monday through Thursday) in Madison, WI, USA. The Land O'Lakes Conference is presented each year by the Division of Pharmacy Professional Development within the School of Pharmacy at the University of Wisconsin-Madison (USA). The purpose of this 3-day conference is to provide an educational forum to discuss issues and applications associated with the analysis of xenobiotics, metabolites, biologics and biomarkers in biological matrices. The conference is designed to include and encourage an open exchange of scientific and methodological applications for bioanalysis. To increase the interactive nature of the conference, the program is a mixture of lectures, interactive discussions and a poster session. This report summarizes the presentations at the 17th Annual Conference.

  9. [Semantics of learned quackery in the 17th and 18th centuries].

    PubMed

    Füssel, Marian

    2004-06-01

    In the 17th and 18th century republic of letters the problem of scientific fraud was met with a discourse of charlatanism. Departing from Johann Burchhard Menckes famous treatise on the Charlatanry of the learned the following essay traces how the accusations of academic and scientific misconduct put in terms of 'charlatanry' primarily helped to produce the new species of the erudite 'charlatan'. Facing a growing complexity of scientific culture this new frame of meaning, structured by numerous examples of scientific misconduct offered a new way of orientation in the world of learning. But besides its cognitive impacts the discourse of charlatanry allowed to create symbolic boundaries, which determined decisions upon the affiliation or non affiliation to the new forming scientific community by separating honourable from dishonourable scientific personae. Speaking of charlatanry therefore always implied a social distinction as much as a scientific. The discourses on charlatanry also mirror differentiations within the scientific field. At first dominated by a critique built on courteous or bourgeois values, the scientific field later on developed its own criteria of appraisal like authorship, originality, transparency etc. Attracting the attention of a further growing public sphere, the explicit verbalisation of claims not relating to the value system of a republic of letters primarily concerned with the production and distribution of knowledge finally led up to a more implicit moral economy of science. A change that at a large scale level can be described both as an internalisation of the values of scientific conduct and differentiation between justiciable and unjusticiable transgressions of the norms set up by the scientific community.

  10. Portuguese tin-glazed earthenware from the 17th century. Part 1: Pigments and glazes characterization

    NASA Astrophysics Data System (ADS)

    Vieira Ferreira, L. F.; Casimiro, T. M.; Colomban, Ph.

    2013-03-01

    Two sherds representative of the Portuguese faience production of the first and second halves of the 17th century were studied carefully with the use of non-invasive spectroscopies, namely: Ground State Diffuse Reflectance Absorption (GSDR), micro-Raman, Fourier-Transform Infrared (FT-IR), Laser Induced Luminescence (LIL) and Proton Induced X-ray (PIXE). These results were compared with the ones obtained for a Chinese Ming porcelain, Wanli period (16th/beginning of the 17th centuries), which served as an influence for the initial Lisbon's faience production. By combining information of the different non-destructive spectroscopic techniques used in this work, it was possible to conclude that: Co3O4 (Co II and Co III) can be found in the silicate matrix and is the blue pigment in the "Especieiro" sample (1st half of the 17th C.). Cobalt olivine silicate (Co2SiO4, Co II only) was clearly identified as the blue pigment in "Aranhões" sample (2nd half of the17th C.) - 824 cm-1 band in the micro-Raman-spectrum. Cobalt aluminate (CoAl2O4, Co II only) is the blue pigment in the Wanli plate - 203 and 512 cm-1 bands in the micro-Raman spectrum. The blue pigment in the 1st half 17th century of Lisbon's production was obtained by addition of a cobalt ore in low concentrations, which gives no specific Raman signature, because of complete dissolution in the glass. However, in most cases of the 2nd half 17th century, the Raman signature was quite evident, from a cobalt silicate. These findings point to the use of higher temperature kilns in the second case.

  11. Portuguese tin-glazed earthenware from the 17th century. Part 1: pigments and glazes characterization.

    PubMed

    Vieira Ferreira, L F; Casimiro, T M; Colomban, Ph

    2013-03-01

    Two sherds representative of the Portuguese faience production of the first and second halves of the 17th century were studied carefully with the use of non-invasive spectroscopies, namely: Ground State Diffuse Reflectance Absorption (GSDR), micro-Raman, Fourier-Transform Infrared (FT-IR), Laser Induced Luminescence (LIL) and Proton Induced X-ray (PIXE). These results were compared with the ones obtained for a Chinese Ming porcelain, Wanli period (16th/beginning of the 17th centuries), which served as an influence for the initial Lisbon's faience production. By combining information of the different non-destructive spectroscopic techniques used in this work, it was possible to conclude that: Co(3)O(4) (Co II and Co III) can be found in the silicate matrix and is the blue pigment in the "Especieiro" sample (1st half of the 17th C.). Cobalt olivine silicate (Co(2)SiO(4), Co II only) was clearly identified as the blue pigment in "Aranhões" sample (2nd half of the 17th C.) - 824 cm(-1) band in the micro-Raman-spectrum. Cobalt aluminate (CoAl(2)O(4), Co II only) is the blue pigment in the Wanli plate - 203 and 512 cm(-1) bands in the micro-Raman spectrum. The blue pigment in the 1st half 17th century of Lisbon's production was obtained by addition of a cobalt ore in low concentrations, which gives no specific Raman signature, because of complete dissolution in the glass. However, in most cases of the 2nd half 17th century, the Raman signature was quite evident, from a cobalt silicate. These findings point to the use of higher temperature kilns in the second case. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. A Statistical Investigation on a Seismic Transient Occurred in Italy Between the 17th and 20th Centuries

    NASA Astrophysics Data System (ADS)

    Bragato, P. L.

    2017-03-01

    According to the historical earthquake catalog of Italy, the country experienced a pulse of seismicity between the 17th century, when the rate of destructive events increased by more than 100%, and the 20th century, characterized by a symmetric decrease. In the present work, I performed a statistical analysis to verify the reliability of such transient, considering different sources of bias and uncertainty, such as completeness and declustering of the catalog, as well as errors on magnitude estimation. I also searched for a confirmation externally to the catalog, analyzing the correlation with the volcanic activity. The similarity is high for the eruptive history of Vesuvius, which agrees on both the main rate changes of the 17th and 20th centuries and on minor variations in the intermediate period. Of general interest, beyond the specific case of Italy, the observed rate changes suggest the existence of large-scale crustal processes taking place within decades and lasting for centuries, responsible for the synchronous activation/deactivation of remote, loosely connected faults in different tectonic domains. Although their origin is still unexplained (I discuss a possible link with the climate changes and the consequent variations of the sea level), their existence and long lasting is critical for seismic hazard computation. In fact, they introduce a hardly predictable time variability that undermines any hypothesis of regularity of the earthquake cycle on individual faults and systems of interconnected faults.

  13. A Statistical Investigation on a Seismic Transient Occurred in Italy Between the 17th and 20th Centuries

    NASA Astrophysics Data System (ADS)

    Bragato, P. L.

    2016-11-01

    According to the historical earthquake catalog of Italy, the country experienced a pulse of seismicity between the 17th century, when the rate of destructive events increased by more than 100%, and the 20th century, characterized by a symmetric decrease. In the present work, I performed a statistical analysis to verify the reliability of such transient, considering different sources of bias and uncertainty, such as completeness and declustering of the catalog, as well as errors on magnitude estimation. I also searched for a confirmation externally to the catalog, analyzing the correlation with the volcanic activity. The similarity is high for the eruptive history of Vesuvius, which agrees on both the main rate changes of the 17th and 20th centuries and on minor variations in the intermediate period. Of general interest, beyond the specific case of Italy, the observed rate changes suggest the existence of large-scale crustal processes taking place within decades and lasting for centuries, responsible for the synchronous activation/deactivation of remote, loosely connected faults in different tectonic domains. Although their origin is still unexplained (I discuss a possible link with the climate changes and the consequent variations of the sea level), their existence and long lasting is critical for seismic hazard computation. In fact, they introduce a hardly predictable time variability that undermines any hypothesis of regularity of the earthquake cycle on individual faults and systems of interconnected faults.

  14. Power Relationships on the Unionized Campus. Proceedings, Annual Conference (17th, April 1989).

    ERIC Educational Resources Information Center

    Douglas, Joel M., Ed.

    Papers from the 17th Annual Conference present observations and analysis of how the power equation has, or has not, been altered by the introduction of faculty and support staff unionism. The first section on power relationships between professors and senates contains: "The Academic as Political Man or Woman" (Seymour Lipset); "Governance: Senates…

  15. My Experience with Alcohol, a 17th-Century Mathematician, and a Personal Decision

    ERIC Educational Resources Information Center

    Eaton, Dennis R.; Rector, Sheila M.

    2009-01-01

    This writing shares the first author's personal experience with alcohol, the negative consequences of his choices, and the ultimate answering of the question, "Am I an alcoholic and should I drink again?" The decision-making process and the eventual answer come from Blaise Pascal, a 17th-century mathematician. This process is explained and…

  16. Why "Worser" Is Better: The Double Comparative in 16th- to 17th-Century English.

    ERIC Educational Resources Information Center

    Schluter, Julia

    2001-01-01

    Investigates the redundantly marked comparative "worser" in relation to its irregular, but etymologically justified, counterpart, "worse." Examines the diachronic development of the form as well as its distribution in the written language of the 16th and 17th centuries. (Author/VWL)

  17. Mosquito Vector Control and Biology in Latin America - A 17th Symposium

    USDA-ARS?s Scientific Manuscript database

    The 17th Annual Latin America American symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 73rd Annual Meeting in Orlando, FL, in April 2007. The principal objective, as for the previous 16 symposia, was to promote participation in the AMCA by vector cont...

  18. Native American Games & European Religious Attitudes in the 16th & 17th Centuries.

    ERIC Educational Resources Information Center

    Eisen, George

    Some aspects of the white-Indian relationship are reflected in the writings of 16th and 17th century observers of Indian pastimes. The Noble Savage image was apparently accepted by French colonists as a consequence of an intellectual disappointment in the contemporary societies. In an age of absolutism and religious intolerance, the picture of the…

  19. Japanese Concepts of Child Development from the Mid-17th to Mid-19th Century.

    ERIC Educational Resources Information Center

    Kojima, Hideo

    1986-01-01

    Summarizes beliefs and values about child rearing from documents written by experts on the mid-17th to mid-19th centuries. The experts argued that children are innately good rather than evil; environmental factors accounted for differences among children rather than innate factors; and children were autonomous rather than passive learners. (HOD)

  20. Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.

    PubMed

    Semple, Graeme

    2010-04-01

    CHI's 17th International Tri-Conference on Molecular Medicine, held in San Francisco, included topics covering the drug discovery process, with an emphasis on lead optimization. This conference report highlights selected presentations on the development of several launched and investigational drugs, including Plerixafor, Trox-1 (CombinatoRX Inc), lorcaserin (Arena Pharmaceuticals Inc), vorapaxar (Merck & Co Inc) and ulimorelin (Tranzyme Pharma Inc).

  1. My Experience with Alcohol, a 17th-Century Mathematician, and a Personal Decision

    ERIC Educational Resources Information Center

    Eaton, Dennis R.; Rector, Sheila M.

    2009-01-01

    This writing shares the first author's personal experience with alcohol, the negative consequences of his choices, and the ultimate answering of the question, "Am I an alcoholic and should I drink again?" The decision-making process and the eventual answer come from Blaise Pascal, a 17th-century mathematician. This process is explained and…

  2. Concurrent phenomena of science and history in the 17th century and their essential interdependence.

    PubMed Central

    Bloch, H.

    1992-01-01

    The explanation for the explosion of science in the 17th century lies in history and medical historiography. Without this approach, it becomes fantasy, accidents, or success stories. Sigerist grasped the essential interdependence of science and history, and had no need for devised reasons or speculation. He realized that once the dark night of the Middle Ages was over, the sciences arose with undreamt of force and accelerated development. The advances in astronomy, mathematics, mechanics, and experimental science benefitted a society developing in seafaring, manufacture, and trade in the 17th century. Sigerist's views make the scientific explosion understandable in human and social terms. He did not overlook the capabilities of some extraordinary individuals, such as Paracelsus (1493-1541), to shape the course of medicine, nor the importance of the mechanistic philosophy in the 17th century. Man makes history and science; hence, we find concurrent phenomena of history and science essentially interdependent. The spirit of experimental science of 17th century England was inspired by the new needs of commercial enterprise for more means of transportation and communication. Likewise, the interest in the mechanics of the pump for waterworks and for the drainage of swamps led Harvey to think of the heart as a pump, and to explain the circulation of the blood in terms of its functioning. PMID:1608066

  3. The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?

    PubMed

    Joerger, Markus; Finn, Stephen P; Cuffe, Sinead; Byrne, Annette T; Gray, Steven G

    2016-11-01

    There is strong pharmaceutical development of agents targeting the IL-17-TH17 pathway for the treatment of psoriasis (Ps) and psoriatic arthritis (PsA). Lung cancer accounts for 28% of all cancer-related deaths worldwide, and roughly 80% of patients with newly-diagnosed non-small cell lung cancer (NSCLC) present with metastatic disease, with a poor prognosis of around 12 months. Therefore, there is a high unmet medical need for the development of new and potent systemic treatments in this deadly disease. The emergence of immunotherapies such as anti-PD-1 or anti-PDL1 as candidate therapies in non-small cell lung cancer (NSCLC) indicates that targeting critical immuno-modulatory cytokines including those within the IL-17-Th1/Th17 axis may have proven benefit in the treatment of lung cancer. Areas covered: In this review we describe the current evidence for aberrant IL-17-Th1/Th17 settings in cancer, particularly with regard to targeting this axis in NSCLC. We further discuss the current agents under pharmaceutical development which could potentially target this axis, and discuss the current limitations and areas of concern regarding the use of these in lung cancer. Expert opinion: Current evidence suggests that moving forward agents targeting the IL-17-Th1/Th17 pathway may have novel new oncoimmunology indications in the treatment paradigm for NSCLC.

  4. Nonmilitary applications of the rocket between the 17th and 20th centuries

    NASA Technical Reports Server (NTRS)

    Sharpe, M. R.

    1977-01-01

    Nonmilitary uses of the rocket through history were investigated. It was found that through the 17th century rockets were used in whaling as harpoon drives. In later years, rockets were used in lifesaving and in commercial signalling at sea. Rocket utilization was traced up to the present application of sending the first men to the moon.

  5. 8. Photocopy of photograph (from 17th Annual Report, 1912, The ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Photocopy of photograph (from 17th Annual Report, 1912, The American Scenic and Historic Preservation Society) Unknown, Photographer, c. 1912 PERSPECTIVE VIEW OF WEST (FRONT) AND NORTH SIDE AS LOCATED AND ALTERED AT PRESENT SITE - Hamilton Grange, (Moved From) 237 West 141 Street to 141st Street & Amsterdam, New York County, NY

  6. John Hall and his epileptic patients--epilepsy management in early 17th century England.

    PubMed

    Betts, T; Betts, H

    1998-10-01

    John Hall, a physician, practised in Stratford in the early 17th century and was the son-in-law of William Shakespeare. During his career he kept records of his patients (in Latin) which he may have been preparing for publication when he died. Despite his instruction for them to be destroyed some were later translated into English and published by another physician. The case records were popular and have recently been reprinted with a commentaryl. We have searched the case records for descriptions of epilepsy and examined the treatments offered (and the attitudes to) this condition in early 17th century England. Treatment consisted of standard remedies ('fumes' of hartshorn and extracts of peony) related to the Galenic system of medicine, plus individual remedies. Interestingly, there is no evidence that the condition was stigmatized.

  7. 17th Workshop on Crystalline Silicon Solar Cells and Modules: Materials and Processes; Workshop Proceedings

    SciTech Connect

    Sopori, B. L.

    2007-08-01

    The National Center for Photovoltaics sponsored the 17th Workshop on Crystalline Silicon Solar Cells & Modules: Materials and Processes, held in Vail, CO, August 5-8, 2007. This meeting provided a forum for an informal exchange of technical and scientific information between international researchers in the photovoltaic and relevant non-photovoltaic fields. The theme of this year's meeting was 'Expanding Technology for a Future Powered by Si Photovoltaics.'

  8. Acupuncture points & use of moxibustion, found in the popular literature & paintings of 17th century Japan.

    PubMed

    Omura, Y

    1984-01-01

    Acupuncture and moxibustion have long been an integral part of Far Eastern oriental medicine. Moxibustion and acupuncture cannot be discussed without each other since both use the same acupuncture point locations and nomenclatures. In the late 17th century, the famous travel diary of Basho, a Japanese master of haiku poetry, made reference to personal use of moxibustion on one of the well-known acupuncture points, stomach 36. Recently, the author found 2 paintings of a 17th century Kyoto geisha house and its surroundings in the Boston Museum of Fine Arts, painted in realistic color by Moronobu, the originator of the Ukiyoe style and a contemporary of Basho. Part of the scene depicts some professional porters at work; on their legs are white scars at some of the well-known acupuncture points, including stomach 36 and spleen 6. The scars appear to be the result of moxibustion. This may indicate the common use of moxibustion on well-known acupuncture points of the lower extremities in late 17th century Japan for professional porters and for people making extensive journeys. Further support of the relatively widespread use of acupuncture and moxibustion is even found in the popular, non-medical literature of late 17th century Japan. In one of the short stories about the life of average people, written by the novelist Saikaku, the details of a young woman giving moxibustion on the back of a young man is realistically described with illustrations. Reports written by some of the foreign physicians who visited Japan during this period were published, describing these methods with illustrations.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. Small-world networks in neuronal populations: a computational perspective.

    PubMed

    Zippo, Antonio G; Gelsomino, Giuliana; Van Duin, Pieter; Nencini, Sara; Caramenti, Gian Carlo; Valente, Maurizio; Biella, Gabriele E M

    2013-08-01

    The analysis of the brain in terms of integrated neural networks may offer insights on the reciprocal relation between structure and information processing. Even with inherent technical limits, many studies acknowledge neuron spatial arrangements and communication modes as key factors. In this perspective, we investigated the functional organization of neuronal networks by explicitly assuming a specific functional topology, the small-world network. We developed two different computational approaches. Firstly, we asked whether neuronal populations actually express small-world properties during a definite task, such as a learning task. For this purpose we developed the Inductive Conceptual Network (ICN), which is a hierarchical bio-inspired spiking network, capable of learning invariant patterns by using variable-order Markov models implemented in its nodes. As a result, we actually observed small-world topologies during learning in the ICN. Speculating that the expression of small-world networks is not solely related to learning tasks, we then built a de facto network assuming that the information processing in the brain may occur through functional small-world topologies. In this de facto network, synchronous spikes reflected functional small-world network dependencies. In order to verify the consistency of the assumption, we tested the null-hypothesis by replacing the small-world networks with random networks. As a result, only small world networks exhibited functional biomimetic characteristics such as timing and rate codes, conventional coding strategies and neuronal avalanches, which are cascades of bursting activities with a power-law distribution. Our results suggest that small-world functional configurations are liable to underpin brain information processing at neuronal level.

  10. PREFACE: 17th International Conference on Microscopy of Semiconducting Materials 2011

    NASA Astrophysics Data System (ADS)

    Walther, T.; Midgley, P. A.

    2011-11-01

    This volume contains invited and contributed papers from the 17th international conference on 'Microscopy of Semiconducting Materials' held at Churchill College, University of Cambridge, on 4-7 April 2011. The meeting was organised under the auspices of the Institute of Physics and supported by the Royal Microscopical Society as well as the Materials Research Society of the USA. This conference series deals with recent advances in semiconductor studies carried out by all forms of microscopy, with an emphasis on electron microscopy and related techniques with high spatial resolution. This time the meeting was attended by 131 delegates from 25 countries world-wide, a record in terms of internationality. As semiconductor devices shrink further new routes of device processing and characterisation need to be developed, and, for the latter, methods that offer sub-nanometre spatial resolution are particularly valuable. The various forms of imaging, diffraction and spectroscopy available in modern microscopes are powerful tools for studying the microstructure, the electronic structure, the chemistry and also electric fields in semiconducting materials. Recent advances in instrumentation, from lens aberration correction in both TEM and STEM instruments, to the development of a wide range of scanning probe techniques, as well as new methods of signal quantification have been presented at this conference. Two examples of topics at this meeting that have attracted a number of interesting studies were: the correlation of microstructural, optical and chemical information at atomic resolution with nanometre-scale resolved maps of the local electrical fields in (In,Al)GaN based semiconductors and tomographic approaches to characterise ensembles of nanowires and stacks of processed layers in devices Figure 1 Figure 1. Opening lecture by Professor Sir Colin J Humphreys. Each manuscript submitted for publication in this proceedings volume has been independently reviewed and revised

  11. Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.

    PubMed

    Terrett, Nick

    2010-04-01

    CHI's 17th International Tri-Conference on Molecular Medicine, held in San Francisco, included topics covering new developments in the field of medicinal chemistry. This conference report highlights selected presentations on fragment-based drug discovery, quantum mechanical energy decomposition for the analysis of SARs, medicinal chemistry strategies and the role of imaging in drug discovery. Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc), GDC-0449 (Chugai Pharmaceutical Co Ltd/Curis Inc/F Hoffmann-La Roche Ltd/Genentech Inc/NCI), RDEA-119 (Ardea Biosciences Inc/Bayer HealthCare AG) and tafamidis (Fx-1006A; FoldRx Pharmaceuticals Inc).

  12. Transient uplift after a 17th-century earthquake along the kuril subduction zone

    USGS Publications Warehouse

    Sawai, Y.; Satake, K.; Kamataki, T.; Nasu, H.; Shishikura, M.; Atwater, B.F.; Horton, B.P.; Kelsey, H.M.; Nagumo, T.; Yamaguchi, M.

    2004-01-01

    In eastern Hokkaido, 60 to 80 kilometers above a subducting oceanic plate, tidal mudflats changed into freshwater forests during the first decades after a 17th-century tsunami. The mudflats gradually rose by a meter, as judged from fossil diatom assemblages. Both the tsunami and the ensuing uplift exceeded any in the region's 200 years of written history, and both resulted from a shallow plate-boundary earthquake of unusually large size along the Kuril subduction zone. This earthquake probably induced more creep farther down the plate boundary than did any of the region's historical events.

  13. Reconstruction of climate in China during 17th-19th centuries using Chinese chronological records

    NASA Astrophysics Data System (ADS)

    Wang, Pao; Lin, Kuan-Hui; Liao, Yi-Chun; Lee, Shih-Yu; Liao, Hsiung-Ming; Pai, Pi-Ling; Fan, I.-Chun

    2017-04-01

    Chinese historical documents are an extremely useful source from which much climate information can be retrieved if treated carefully. This is especially relevant to the reconstruction of climate in East Asia in the last 2000 years as the Chinese has kept official chronicles since 500BC and China also represents a large portion of East Asia's land. In addition, there are also local records in many cities and counties. When available, such documentary sources are often superior to environmental proxy data, especially in the time resolution as they usually provide at least annual resolution and even as high as daily records in some cases. This research will report on our recent advances on using a new REACHS dataset that collects primarily documented meteorological records from thousands of imperial and local chronicles in the Chinese history for more than 2000 years. The meteorological records were digitized and coded in the relational database management system in which accurate time (from yearly to daily), space (from province to city/county) and event (from meteorological to phonological and social) information is carefully reserved for analysis. We then formed digital climate series and performed time series and spatial analysis on them to obtain their temporal and spatial characteristics. Our present research results on the annual and seasonal temperature reconstruction during 17th-19th indicates lower temperature in the 17th century. There were also strangely high occurrence frequency of summer snowfall records in the lower reaches of Yangtze River during the Maunder Minimum. Reconstructed precipitation series fluctuated with strong regional character in the Northeast, Central-east and Southeast China. Spectral analysis shows that precipitation series have significant periodicity of 3-5 and 8-12 years during the period, suggesting strong interannual variability and different regional signatures. Flood happened frequently but long lasting drought was more

  14. Too Little too Soon: The Literature of Deaf Education in 17th-Century Britain (Part II).

    ERIC Educational Resources Information Center

    Hoolihan, Christopher

    1985-01-01

    The article describes the growth in literature on deaf education in 17th century Britain. Noted is the work of John Wallis, William Holder, George Dalgarno, Anton Deusing, and Johann Conrad Amman. (CL)

  15. Food flora in 17th century northeast region of Brazil in Historia Naturalis Brasiliae

    PubMed Central

    2014-01-01

    Background This article reports historical ethnobotany research conducted from a study of the work Historia Naturalis Brasiliae (Natural History of Brazil), authored by Piso and Marcgrave and published in 1648, with main focus on Caatinga of northeast region of Brazil. Methods Focusing the content analysis on the section dedicated to plant species with multiple uses, Marcgrave's contribution to the aforementioned work, this research had the following objectives: the retrieval of 17th century knowledge about the food uses of the flora in the northeast region of Brazil, including the taxonomic classifications; the identification of plant parts, their modes of consumption and the ethnic group of consumers; and the verification of the use of these species over time. Results The use of 80 food species at the time of the publication of the work is indicated, some of which are endemic to the Caatinga, such as “umbu” (Spondias tuberosa Arruda), “mandacaru” (Cereus jamacaru DC.) and “carnauba” (Copernicia cerifera Mart.). It is noticeable that among the species listed by Marcgrave, some species still lack current studies indicating their real nutritional value. The present study is an unprecedented work because it introduces, in a systematic way, the food plants described in a study of 17th century Brazil. Conclusions Finally, this study makes information about plants consumed in the past accessible, aiming to provide material for studies that could develop new food products today. PMID:24965737

  16. Food flora in 17th century Northeast region of Brazil in Historia Naturalis Brasiliae.

    PubMed

    Medeiros, Maria Franco Trindade; Albuquerque, Ulysses Paulino

    2014-06-25

    This article reports historical ethnobotany research conducted from a study of the work Historia Naturalis Brasiliae (Natural History of Brazil), authored by Piso and Marcgrave and published in 1648, with main focus on Caatinga of northeast region of Brazil. Focusing the content analysis on the section dedicated to plant species with multiple uses, Marcgrave's contribution to the aforementioned work, this research had the following objectives: the retrieval of 17th century knowledge about the food uses of the flora in the northeast region of Brazil, including the taxonomic classifications; the identification of plant parts, their modes of consumption and the ethnic group of consumers; and the verification of the use of these species over time. The use of 80 food species at the time of the publication of the work is indicated, some of which are endemic to the Caatinga, such as "umbu" (Spondias tuberosa Arruda), "mandacaru" (Cereus jamacaru DC.) and "carnauba" (Copernicia cerifera Mart.). It is noticeable that among the species listed by Marcgrave, some species still lack current studies indicating their real nutritional value. The present study is an unprecedented work because it introduces, in a systematic way, the food plants described in a study of 17th century Brazil. Finally, this study makes information about plants consumed in the past accessible, aiming to provide material for studies that could develop new food products today.

  17. Malaria in the Renaissance: remedies from European herbals from the 16th and 17th century.

    PubMed

    Adams, Michael; Alther, Wandana; Kessler, Michael; Kluge, Martin; Hamburger, Matthias

    2011-01-27

    From antiquity up into the 20th century tertian and quartan malaria which are caused by the parasites Plasmodium vivax and Plasmodium malariae were widespread in Central Europe. Hundreds of different remedies against malaria can be found in herbals from the Renaissance. To document and discuss from a modern pharmacological viewpoint the old remedies described in eight 16th and 17th century herbals written in German. Eight of the most important herbals of the 16th and 17th century including Bock (1577), Fuchs (1543), Matthiolus (1590), Lonicerus (1560), Brunfels (1532), Zwinger (1696), and Tabernaemontanus (1591 and 1678) were searched for terms related to malaria, and documented plants and recipes described for its treatment. Additionally the overlapping of these remedies with those in De Materia Medica by the Greek physician Dioscorides was studied. Three hundred and fourteen taxa were identified in the herbals for this indication. Recent pharmacological data was found for just 5% of them. The influence of De Materia Medica was shown to be negligible with only 3.5% of the remedies in common. European Renaissance herbals may be a valuable source of information for the selection of plants for focussed antiplasmodial screening programmes, but have received only little scientific attention. Antimalarial remedies from these herbals must be viewed as independent sources of knowledge separate from Dioscorides' De Materia Medica. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  18. Paleogenetic study on the 17th century Korean mummy with atherosclerotic cardiovascular disease

    PubMed Central

    Hong, Jong Ha; Kim, Yusu; Lee, Soong Deok

    2017-01-01

    While atherosclerotic cardiovascular disease (ASCVD) is known to be common among modern people exposed to various risk factors, recent paleopathological studies have shown that it affected ancient populations much more frequently than expected. In 2010, we investigated a 17th century Korean female mummy with presumptive ASCVD signs. Although the resulting report was a rare and invaluable conjecture on the disease status of an ancient East Asian population, the diagnosis had been based only on anatomical and radiological techniques, and so could not confirm the existence of ASCVD in the mummy. In the present study, we thus performed a paleogenetic analysis to supplement the previous conventional diagnosis of ASCVD. In aDNA extracted from the same Korean mummy, we identified the risk alleles of seven different SNPs (rs5351, rs10757274, rs2383206, rs2383207, rs10757278, rs4380028 and rs1333049) that had already been revealed to be the major risk loci of ASCVD in East Asian populations. The reliability of this study could be enhanced by cross-validation using two different analyses: Sanger and SNaPshot techniques. We were able to establish that the 17th century Korean female had a strong genetic predisposition to increased risk of ASCVD. The current paleogenetic diagnosis, the first of its kind outside Europe, re-confirms its utility as an adjunct modality for confirmatory diagnosis of ancient ASCVD. PMID:28813480

  19. LATIN AS A LANGUAGE OF INTERNATIONAL COMMUNICATIVE STATUS: MEDICINE OF THE 16TH-17TH CENTURIES.

    PubMed

    Bieliaieva, O; Lysanets, Yu; Melaschenko, M

    2017-01-01

    The research paper is of interdisciplinary nature, written at the crossroads of the history of medicine, functional stylistics and terminology science. The choice of the 16th century as a starting point of the study is due to the fact that quality changes in book and manuscript writing that took place during this period led to unprecedented development and dissemination of scientific knowledge, including biomedical. The 16th century embraces the life and work of such prominent figures in the history of medicine, as Andreas Vesalius, Gabriele Fallopian, Bartolomeo Eustachi, and Girolamo Fracastoro. The 17th century, which is called the century of "scientific revolution", left not less honourable names in the history of medicine - William Harvey, Marcello Malpighi, Thomas Willis, Jean Pecquet, Francis Glisson, Thomas Sydenham. In the context of this study, these prominent figures are interesting due to the fact that their works were written in Latin and constitute the prototypes of modern scientific style, in particular of such genres as thesis, monograph, scientific article, scientific report, polemic presentation, textbook. On the basis of extensive factual material, it has been demonstrated that during 16th-17th centuries, Latin acted as a fully developed language with a clearly oriented international status. As one of basic tools in scientific knowledge, Latin not only performed the epistemological function which was the priority for the development of medicine, but also served as a means of accumulation, reception, transmission and popularization of achievements in various areas of medical science.

  20. Care of the insane in Lübeck during the 17th and 18th centuries.

    PubMed

    Dilling, Horst; Thomsen, Hans Peter; Hohagen, Fritz

    2010-12-01

    Only selected aspects of the history of the House of the Poor Insane in the Hanseatic Free City of Lübeck have been studied to date.This article presents the results of an entire source study of this small institution in the 17th and 18th centuries, and briefly also during the next 40 years after the opening of a new building. In addition to the minute-book of the Governors, now kept in the Lübeck Municipal Archives, the results are based primarily on the account-books,which illustrate the institution's social history and activities. Examples are given. During most of the 17th century, the House was generally rather like a prison for the insane, but at the end of this century and in the early 18th there was a reform phase.This was followed by phases of repression and 'containment' at the end of the 18th century and in the early 19th century, before a renewed reform by the medical profession.The findings for Lübeck are compared with the development of inpatient care in institutions elsewhere, and the decisive factors in Lübeck are discussed.

  1. Proteomics applied to the authentication of fish glue: application to a 17th century artwork sample.

    PubMed

    Dallongeville, Sophie; Richter, Mark; Schäfer, Stephan; Kühlenthal, Michael; Garnier, Nicolas; Rolando, Christian; Tokarski, Caroline

    2013-09-21

    This work provides the first identification of fish glue from a few micrograms of a 17(th) century artwork sample using an adapted proteomics approach. Fish glue has been widely used as a binder in various art objects such as paintings, manuscripts or polychrome objects however its authentication remains particularly challenging. The lack of information on fish species in genomic and proteomic databases represents a major drawback. A supplementary difficulty is provided by the historical sample features, i.e. a few micrograms of a 17(th) century polychrome object with a multilayered structure. SYPRO® Ruby staining was used as a screening technique to probe the presence of proteins in the sample cross-section. Results revealed the presence of several layers containing proteins among which a thin proteinaceous layer located between the silver leaf and the glaze. This thin layer is described as fish glue coating by historical sources but its composition has not been identified yet. The optimized methodology, based on high resolution mass spectrometry and adapted bioinformatic tools, was successfully applied to 50 μg of a polychromy sample and resulted in the identification of several collagen proteins. Extensive interpretation of data generated by tandem mass spectrometry allowed the identification of proteins from different biological origins. In particular, seven peptides specific to fish collagen proteins were identified for the first time proving the presence of fish glue in the sample and corroborating information found in historical texts dealing with the polychromy technique.

  2. Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries)

    NASA Astrophysics Data System (ADS)

    Amorim, Inês; Sousa Silva, Luís; Garcia, João Carlos

    2017-04-01

    Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries) Inês Amorim CITCEM, Department of History, Political and International Studies, U. of Porto, Portugal. Luís Sousa Silva CITCEM, PhD Fellowship - FCT. João Carlos Garcia CIUHCT, Geography Department, U. of Porto, Portugal. The first major national project on Historical Climatology in Portugal, called "KLIMHIST: Reconstruction and model simulations of past climate in Portugal using documentary and early instrumental sources (17th-19th centuries)", ended in September 2015, coordinated by Maria João Alcoforado. This project began in March 2012 and counted on an interdisciplinary team of researchers from four Portuguese institutions (Centre of Geographical Studies, University of Trás-os-Montes and Alto Douro, University of Porto, and University of Évora), from different fields of knowledge (Geography, History, Biology, Climatology and Meteorology). The team networked and collaborated with other international research groups on Climate Change and Historical Climatology, resulting in several publications. This project aimed to reconstruct thermal and rainfall patterns in Portugal between the 17th and 19th centuries, as well as identify the main hydrometeorological extremes that occurred over that period. The basic methodology consisted in combining information from different types of anthropogenic sources (descriptive and instrumental) and natural sources (tree rings and geothermal holes), so as to develop climate change models of the past. The data collected were stored in a digital database, which can be searched by source, date, location and type of event. This database, which will be made publically available soon, contains about 3500 weather/climate-related records, which have begun to be studied, processed and published. Following this seminal project, other initiatives have taken place in Portugal in the area of Historical Climatology, namely a Ph

  3. Biological Warfare Plan in the 17th Century—the Siege of Candia, 1648–1669.

    PubMed

    Thalassinou, Eleni; Tsiamis, Costas; Poulakou-Rebelakou, Effie; Hatzakis, Angelos

    2015-12-01

    A little-known effort to conduct biological warfare occurred during the 17th century. The incident transpired during the Venetian–Ottoman War, when the city of Candia (now Heraklion, Greece) was under siege by the Ottomans (1648–1669). The data we describe, obtained from the Archives of the Venetian State, are related to an operation organized by the Venetian Intelligence Services, which aimed at lifting the siege by infecting the Ottoman soldiers with plague by attacking them with a liquid made from the spleens and buboes of plague victims. Although the plan was perfectly organized, and the deadly mixture was ready to use, the attack was ultimately never carried out. The conception and the detailed cynical planning of the attack on Candia illustrate a dangerous way of thinking about the use of biological weapons and the absence of reservations when potential users, within their religious framework, cast their enemies as undeserving of humanitarian consideration.

  4. [Vitalism and mechanism: their meanings in the milieu of the 17th and 18th centuries].

    PubMed

    Hwang, S I

    1993-01-01

    The views on the life in the early modern period (the 17th and 18th centuries) with their socio-cultural backgrounds and their meanings at that time were discussed in this paper. Those views discussed here were the dualistic, mechanistic one of Rene Descartes (1596-1650), the animistic, vitalistic one of Georg Ernst Stahl (1660-1734), and the monistic, mechanistic one of Julien Offray de la Mettrie (1709-1751). Author stressed that the processes of their view formation were influenced by the wide range of the various political and religious factors as well as the scientific, medical facts and opinions at that time, and that not only the contents of the views but also their historical contexts should be pursued in the study on the medical thoughts.

  5. Role of Melatonin in the Regulation of Differentiation of T Cells Producing Interleukin-17 (Th17).

    PubMed

    Kuklina, E M; Glebezdina, N S; Nekrasova, I V

    2016-03-01

    We studied the ability of melatonin in physiological and pharmacological concentrations to induce and/or regulate differentiation of T cells producing IL-17 (Th17). This hormone produced the opposite effect on CD4+T cells, which depended on their activation status. Melatonin induced the synthesis of IL-17A by intact T cells, but had little effect on activated cells. Melatonin in high (pharmacological) concentration decreased the intracellular expression of this cytokine under conditions of polyclonal activation. Melatonin had a dose-depended effect. Taking into the fact that Th17 cells play an important role in the immune defense, it can be suggested that the regulation of their activity by melatonin contributes to this process.

  6. Combined dendrochronological and radiocarbon dating of six Russian icons from the 15th-17th centuries

    NASA Astrophysics Data System (ADS)

    Dolgikh, A. V.; Matskovsky, V. V.; Voronin, K. V.; Solomina, O. N.

    2017-06-01

    The results of dendrochronological and radiocarbon dating by means of accelerator mass spectrometry (AMS) of six medieval icons, originating from northern European Russia and painted on wooden panels made from Scots pine, dated to the 15th to 17th centuries are presented. The panels of each icon were studied using dendrochronology. Five to six AMS dates were obtained for four icons. Although five icons were dendro-dated successfully, one failed to be reliably cross-dated with the existing master tree-ring chronologies and it was dated by radiocarbon wiggle-matching. Dendrochronological dating and wiggle-matching of radiocarbon dates allowed us to determine the narrow chronological intervals of icon creation.

  7. Raman spectroscopy analysis of pigments on 16-17th c. Persian manuscripts

    NASA Astrophysics Data System (ADS)

    Muralha, Vânia S. F.; Burgio, Lucia; Clark, Robin J. H.

    2012-06-01

    The palette of four Persian manuscripts of the 16th and 17th centuries were established by Raman microscopy to include lazurite, red lead, vermilion, orpiment, a carbon-based black, lead white, malachite, haematite, indigo, carmine and pararealgar. The first five pigments were identified on all four manuscripts, as previously found for other Islamic manuscripts of this period. The findings were compared with information available in treatises on Persian painting techniques. Red lead, although identified on all of the manuscripts analysed in this study as the main red pigment, is seldom mentioned in the literature. Two unusual pigments were also identified: the intermediate phase between realgar and pararealgar in the manuscript Timur namah, and carmine in the manuscript Shah namah. Although the established palette comprises few pigments, it was found that the illuminations were enhanced by the use of pigment mixtures, the components of which could be identified by Raman microscopy.

  8. Biological Warfare Plan in the 17th Century—the Siege of Candia, 1648–1669

    PubMed Central

    Thalassinou, Eleni; Poulakou-Rebelakou, Effie; Hatzakis, Angelos

    2015-01-01

    A little-known effort to conduct biological warfare occurred during the 17th century. The incident transpired during the Venetian–Ottoman War, when the city of Candia (now Heraklion, Greece) was under siege by the Ottomans (1648–1669). The data we describe, obtained from the Archives of the Venetian State, are related to an operation organized by the Venetian Intelligence Services, which aimed at lifting the siege by infecting the Ottoman soldiers with plague by attacking them with a liquid made from the spleens and buboes of plague victims. Although the plan was perfectly organized, and the deadly mixture was ready to use, the attack was ultimately never carried out. The conception and the detailed cynical planning of the attack on Candia illustrate a dangerous way of thinking about the use of biological weapons and the absence of reservations when potential users, within their religious framework, cast their enemies as undeserving of humanitarian consideration. PMID:26894254

  9. [Nicolaus Steno's geometrical description of muscle: the investigation of muscle movements in the 17th century].

    PubMed

    Anzai, Natsume; Sawai, Tadashi; Sakai, Tatsuo

    2014-03-01

    Famous geologist Nicolaus Steno (1638-1686) was known as a skillful anatomist in his time. His main work about anatomy is "Elementorum myologiae specimen, seu musculi descriptio geometrica". Steno introduced geometrical representation into muscle study. His purpose was to handle muscle movements in the style of Cartesian mechanical philosophy, assuming muscle fibers as the structural and functional unit of muscle. Steno modelled muscles as parallelepiped integrations of fibers. Steno thought the shortening of muscle fibers modified parallelepiped integration and its modification resulted in muscle movements. His parallelepiped model enabled the regarding of muscles as objects of physics. Steno's assumption and model built a methodological foundation of mechanistic physiology of muscle, and influenced latter 17th century thinkers, especially Borelli.

  10. Circulating Th17, Th22, and Th1 cells are increased in psoriasis.

    PubMed

    Kagami, Shinji; Rizzo, Heather L; Lee, Jennifer J; Koguchi, Yoshinobu; Blauvelt, Andrew

    2010-05-01

    Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals. CCR6 was the best cell surface marker for IL-17A+ cells when compared with IL-23R or CD161. CCR6+, IL-17A+, IL-22+, CCR6+IL-17A+, CCR6+IL-22+, CCR6+tumor necrosis factor-alpha+, IL-17A+IFN-gamma-, IL-17A+IL-22+IFN-gamma-, and IL-17A+IL-22-IFN-gamma- cells were increased in psoriatics (all values P<0.001), indicating elevations in circulating Th17 cells, using multiple criteria to define these cells. Th22 (IL-17A-IL-22+IFN-gamma-, P<0.05) and Th1 (IL-17A-IFN-gamma+, P<0.05) cells were also increased in psoriatics, but to a lesser extent. Inhibition of either NF-kappaB or STAT3 in vitro blocked cytokine production by both Th17 and Th1 cells. Circulating levels of Th17 and Th1 cells decreased in a subset of five psoriasis patients serially evaluated following induction therapy with infliximab. In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis.

  11. [Richard Morton (1637-1698)--the distinguished physician of the 17th century].

    PubMed

    Kontić, Olga; Vasiljević, Nadja; Jorga, Jagoda; Lakić, Aneta; Jasović-Gasić, Miroslava

    2009-01-01

    Richard Morton was a distinguished physician of the 17th century. He was born in Suffolk, England, on July 30th 1637. Morton published three works but his landmark paper was "Phthisiologia, seu exercitationes de phthisi, tribus libris comprehensae" published in 1689, dedicated to William III. The book established his reputation at home and abroad lasting for over a century. Pulmonary tuberculosis was very frequent in the 17th century in England. He was the first physician ever to state that tubercles were always present in its pulmonary form. When we add to these momentous observations and their rational explanation the facts that he was the first physician to state categorically that tubercles are always present in phthisis, we must agree that Morton richly deserves his honoured place in the long list of those who have contributed to the solution of the problem of tuberculosis. Morton first described and gave conclusions of numerous today well known and already examined illnesses. In 1694 he gave first notes about the psychiatric illness which we today call "anorexia nervosa", calling it "nervous consumption". His chapters on treatment are long and contain a sound basis of common sense as indicated by his instructions on general management. He stresses the need for an adequate diet, an environment free from fog and smoke, and the desirability of ensuring a moderate amount of exercise. All Morton's therapeutic dicta are in their humanity and thoughtful care in striking contrast to the regimen of copious bleeding and semi-starvation inflicted by the later generation of physicians. Confirmation of his achievements and his teaching can be found in today's medical practice.

  12. PREFACE: 17th International Conference on Textures of Materials (ICOTOM 17)

    NASA Astrophysics Data System (ADS)

    Skrotzki, Werner; Oertel, Carl-Georg

    2015-04-01

    The 17th International Conference on Textures of Materials (ICOTOM 17) took place in Dresden, Germany, August 24-29, 2014. It belongs to the "triennial" series of ICOTOM meetings with a long tradition, starting in 1969 - Clausthal, 1971 - Cracow, 1973 - Pont-à-Mousson, 1975 - Cambridge, 1978 - Aachen, 1981 - Tokyo, 1984 - Noordwijkerhout, 1987 - Santa Fe, 1990 - Avignon, 1993 - Clausthal, 1996 - Xian, 1999 - Montreal, 2002 - Seoul, 2005 - Leuven, 2008 - Pittsburgh, 2011 - Mumbai, 2014 - Dresden. ICOTOM 17 was hosted by the Dresden University of Technology, Institute of Structural Physics. Following the tradition of the ICOTOM conferences, the main focus of ICOTOM-17 was to promote and strengthen the fundamental understanding of the basic processes that govern the formation of texture and its relation to the properties of polycrystalline materials. Nonetheless, it was the aim to forge links between basic research on model materials and applied research on engineering materials of technical importance. Thus, ICOTOM 17 provided a forum for the presentation and discussion of recent progress in research of texture and related anisotropy of mechanical and functional properties of all kinds of polycrystalline materials including natural materials like rocks. Particular attention was paid to recent advances in texture measurement and analysis as well as modeling of texture development for all kinds of processes like solidification, plastic deformation, recrystallization and grain growth, phase transformations, thin film deposition, etc. Hence, ICOTOM 17 was of great interest to materials scientists, engineers from many different areas and geoscientists. The topics covered by ICOTOM 17 were: 1. Mathematical, numerical and statistical methods of texture analysis 2. Deformation textures 3. Crystallization, recrystallization and growth textures 4. Transformation textures 5. Textures in functional materials 6. Textures in advanced materials 7. Textures in rocks 8. Texture

  13. Limits on efficient computation in the physical world

    NASA Astrophysics Data System (ADS)

    Aaronson, Scott Joel

    More than a speculative technology, quantum computing seems to challenge our most basic intuitions about how the physical world should behave. In this thesis I show that, while some intuitions from classical computer science must be jettisoned in the light of modern physics, many others emerge nearly unscathed; and I use powerful tools from computational complexity theory to help determine which are which. In the first part of the thesis, I attack the common belief that quantum computing resembles classical exponential parallelism, by showing that quantum computers would face serious limitations on a wider range of problems than was previously known. In particular, any quantum algorithm that solves the collision problem---that of deciding whether a sequence of n integers is one-to-one or two-to-one---must query the sequence O (n1/5) times. This resolves a question that was open for years; previously no lower bound better than constant was known. A corollary is that there is no "black-box" quantum algorithm to break cryptographic hash functions or solve the Graph Isomorphism problem in polynomial time. I also show that relative to an oracle, quantum computers could not solve NP-complete problems in polynomial time, even with the help of nonuniform "quantum advice states"; and that any quantum algorithm needs O (2n/4/n) queries to find a local minimum of a black-box function on the n-dimensional hypercube. Surprisingly, the latter result also leads to new classical lower bounds for the local search problem. Finally, I give new lower bounds on quantum one-way communication complexity, and on the quantum query complexity of total Boolean functions and recursive Fourier sampling. The second part of the thesis studies the relationship of the quantum computing model to physical reality. I first examine the arguments of Leonid Levin, Stephen Wolfram, and others who believe quantum computing to be fundamentally impossible. I find their arguments unconvincing without a "Sure

  14. Mycobacterium tuberculosis complex detection in human remains: tuberculosis spread since the 17th century in Rio de Janeiro, Brazil.

    PubMed

    Jaeger, Lauren Hubert; Leles, Daniela; Lima, Valdirene dos Santos; da Silva, Laura da Piedade; Dias, Ondemar; Iñiguez, Alena Mayo

    2012-06-01

    Paleogenetic analysis for tuberculosis (TB) was conducted on bone and sediment samples dating from the 17th to 19th centuries from the archeological site of Nossa Senhora do Carmo Church in Rio de Janeiro, Brazil. Forty samples were analyzed, corresponding to 32 individuals from 28 burials, 22 of primary type and 6 of secondary type. The samples were collected following strict paleogenetic investigation guidelines and submitted to ancient DNA (aDNA) extraction. In order to detect TB infection, aDNA hybridizations with the molecular targets of Mycobacterium tuberculosis complex (MTC) IS6110 and IS1081 were applied. Additionally, the ancestry of individuals was assessed by human mitochondrial DNA (mtDNA) analysis of hypervariable segment I (HVS-I) sequence polymorphisms. The results of aDNA hybridizations demonstrated varying levels of MTC intensity in 17/32 individuals (53.1%), using the IS6110 target. The IS1081 MTC target showed lower sensitivity, confirming TB positivity in 10/32 (31.2%) individuals. The mtDNA analysis allowed the recovery of HVS-I sequences in 23/32 individuals (71.8%). The majority of these individuals (21/23, 91.3%) were of European ancestry, especially in primary burials. Haplogroups U, J, V, T, K, N, H and R, were identified with haplogroup U being the most frequent at 6/23 (26.1%). African and Amerindian mtDNA haplogroups were observed in two individuals in secondary burials. In spite of the ecclesiastic and aristocratic bias of the population of the study, human ancestry analysis revealed the prominent contribution of Europeans in the introduction or spread of TB in the New World.

  15. Reconstructing early 17th century estuarine drought conditions from Jamestown oysters.

    PubMed

    Harding, Juliana M; Spero, Howard J; Mann, Roger; Herbert, Gregory S; Sliko, Jennifer L

    2010-06-08

    Oysters (Crassostrea virginica) were a central component of the Chesapeake Bay ecosystem in 1607 when European settlers established Jamestown, VA, the first permanent English settlement in North America. These estuarine bivalves were an important food resource during the early years of the James Fort (Jamestown) settlement while the colonists were struggling to survive in the face of inadequate supplies and a severe regional drought. Although oyster shells were discarded as trash after the oysters were eaten, the environmental and ecological data recorded in the bivalve geochemistry during shell deposition remain intact over centuries, thereby providing a unique window into conditions during the earliest Jamestown years. We compare oxygen isotope data from these 17th century oyster shells with modern shells to quantify and contrast estuarine salinity, season of oyster collection, and shell provenance during Jamestown colonization (1609-1616) and the 21st century. Data show that oysters were collected during an extended drought between fall 1611 and summer 1612. The drought shifted the 14 psu isohaline above Jamestown Island, facilitating individual oyster growth and extension of oyster habitat upriver toward the colony, thereby enhancing local oyster food resources. Data from distinct well layers suggest that the colonists also obtained oysters from reefs near Chesapeake Bay to augment oyster resources near Jamestown Island. The oyster shell season of harvest reconstructions suggest that these data come from either a 1611 well with a very short useful period or an undocumented older well abandoned by late 1611.

  16. ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

    PubMed Central

    Chen, Xi; Madar, Aviv; Carpenito, Carmine; McGettigan, Shannon E.; Frigault, Matthew J.; Lee, Jihyun; Posey, Avery D.; Scholler, John; Scholler, Nathalie; Bonneau, Richard

    2014-01-01

    With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been shown to expand and persist in patients with nonlymphoid tumors. Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence. Compared with CARs containing the CD3ζ chain alone, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A, IL-17F, and IL-22 following antigen recognition. In addition, T cells redirected with an ICOS-based CAR maintained a core molecular signature characteristic of TH17 cells and expressed higher levels of RORC, CD161, IL1R-1, and NCS1. Of note, ICOS signaling also induced the expression of IFN-γ and T-bet, consistent with a TH17/TH1 bipolarization. When transferred into mice with established tumors, TH17 cells that were redirected with ICOS-based CARs mediated efficient antitumor responses and showed enhanced persistence compared with CD28- or 4-1BB-based CAR T cells. Thus, redirection of TH17 cells with a CAR encoding the ICOS intracellular domain is a promising approach to augment the function and persistence of CAR T cells in hematologic malignancies. PMID:24986688

  17. ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells.

    PubMed

    Guedan, Sonia; Chen, Xi; Madar, Aviv; Carpenito, Carmine; McGettigan, Shannon E; Frigault, Matthew J; Lee, Jihyun; Posey, Avery D; Scholler, John; Scholler, Nathalie; Bonneau, Richard; June, Carl H

    2014-08-14

    With the notable exception of B-cell malignancies, the efficacy of chimeric antigen receptor (CAR) T cells has been limited, and CAR T cells have not been shown to expand and persist in patients with nonlymphoid tumors. Here we demonstrate that redirection of primary human T cells with a CAR containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-producing effector cells that show enhanced persistence. Compared with CARs containing the CD3ζ chain alone, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A, IL-17F, and IL-22 following antigen recognition. In addition, T cells redirected with an ICOS-based CAR maintained a core molecular signature characteristic of TH17 cells and expressed higher levels of RORC, CD161, IL1R-1, and NCS1. Of note, ICOS signaling also induced the expression of IFN-γ and T-bet, consistent with a TH17/TH1 bipolarization. When transferred into mice with established tumors, TH17 cells that were redirected with ICOS-based CARs mediated efficient antitumor responses and showed enhanced persistence compared with CD28- or 4-1BB-based CAR T cells. Thus, redirection of TH17 cells with a CAR encoding the ICOS intracellular domain is a promising approach to augment the function and persistence of CAR T cells in hematologic malignancies.

  18. Great Barrier Reef coral luminescence reveals rainfall variability over northeastern Australia since the 17th century

    NASA Astrophysics Data System (ADS)

    Lough, Janice M.

    2011-06-01

    Northeast tropical Queensland rainfall is concentrated in the summer half year and characterized by high interannual variability, partly related to El Niño-Southern Oscillation (ENSO) events. This results in highly variable river flows affecting nearshore coral reefs of the Great Barrier Reef, Australia. Freshwater flood events are recorded in long-lived, annually banded massive coral skeletons as luminescent lines. Quantitative measurements of luminescence intensity were made for 20 Porites coral cores from nearshore reef sites between 11°S and 23°S. Seventeen of the coral luminescence series were significantly correlated with an instrumental record of northeast Queensland summer rainfall and were used to develop seven significantly calibrated and verified rainfall reconstructions based on between 17 (starting 1891) and 1 (starting 1639) coral series. The longest reconstruction, based on more than one coral, provides insights into northeast Queensland rainfall variability from the late 17th century. Comparisons with various independent climate proxies are equivocal: the magnitude and significance of relationships with, for example, a proxy ENSO index vary through time. An extended drier period reconstructed from approximately the 1760s to the 1850s is associated with lower interannual rainfall variability. Since the late 19th century average rainfall and its variability have significantly increased, with wet and dry extremes becoming more frequent than in earlier centuries. This suggests that a warming global climate maybe associated with more variable tropical Queensland rainfall.

  19. A Possible Case of Cherubism in a 17th-Century Korean Mummy

    PubMed Central

    Spigelman, Mark; Sarig, Rachel; Lim, Do-Sun; Lee, In Sun; Oh, Chang Seok; May, Hila; Boaretto, Elisabetta; Kim, Yi-Suk; Lee, Soong Deok; Peled, Nathan; Kim, Myeung Ju; Toledano, Talya; Bar-Gal, Gila Kahila

    2014-01-01

    Cherubism is a benign fibro-osseous disease of childhood limited specifically to the maxilla and mandible. The progressive replacement of the jaw bones with expansile multilocular cystic lesions causes eventual prominence of the lower face, and hence the classic “cherubic” phenotype reflecting variable extents of jaw hypertrophy. Histologically, this condition has been characterized as replacement of the normal bone matrix with multicystic pockets of fibrous stroma and osteoclastic giant cells. Because of radiographic features common to both, primarily the presence of multiloculated lucencies with heterogeneous “ground-glass” sclerosis on CT imaging, cherubism was long mistaken for a craniofacial subtype of fibrous dysplasia. In 1999, however, the distinct genetic basis for cherubism was mapped to chromosome 4p16.3 and the SH-3 binding protein SH3BP2. But while there are already three suspected cases of fibrous dysplasia amongst archaeological populations, no definitive cases of cherubism have yet been reported in historical populations. In the current study we describe micro- and macro-structural changes in the face of a 17th century Joseon Dynasty Korean mummy which may coincide with the clinic-pathologic and radiologic features of cherubism. PMID:25093864

  20. Gerrit Dou: 17th century Dutch artist portraying dentists at work.

    PubMed

    Christen, Arden G; Christen, Joan A

    2002-07-01

    The Dutch painter, Gerrit Dou (1613-1675), was, during his lifetime, a prestigious and highly paid artist. Critics and collectors of that era marveled at his extraordinary technical skill, his masterful illusionism and his keen portrayal of everyday life. He was the first artist to perfect the technique of "fine painting"--the production of small, detailed pictures wherein subjects are painted in a photographically realistic style. Because of his exceptional skill in this technique, the brushwork in his painting was almost invisible. Additionally, he masterfully used light and shade to achieve the effect of a third dimension. In many of his portraits, subjects stare ahead from inside a window (or niche), whose sill is overflowing with small, familiar objects. Dou's focus was on 17th century Holland and his work included: portraits, genre (scenes of everyday life) and religious themes. Between 1628 and 1675, he painted about three hundred pictures: six of these portrayed dentists at work. Most artists of those days depicted dentists as plying their trade in theatrical, circus-like environments, as in crowded county fairs. However, Dou's dentists interact with their patients in a realistic, professional manner. In this article, his most famous dental painting, "The Dentist," created in 1672, is analyzed in detail. Over the centuries, Dou's public recognition has faded into obscurity. However, his exceptional talents are currently being rediscovered.

  1. [Chemistry of life: ferments and fermentation in 17th-century iatrochemistry].

    PubMed

    Clericuzio, Antonio

    2003-01-01

    The concepts of ferment and fermentation played an important, though heretofore neglected, role in 17th-century physiology. Though these notions can be found in ancient philosophy and medicine, as well as in medieval medicine, they became integral part of the chemical medicine that was advocated by Paracelsus and his school. Paracelsians made fermentation a central concept in their successful effort to give chemical foundation to medicine. Jean Baptiste van Helmont and Sylvius used the concepts of ferment and fermentation to explain a variety of physiological processes in human body. Corpuscular philosophers like Robert Boyle and Thomas Willis reinterpreted these notions in corpuscular terms and separated the concept of ferment from that of fermentation. In the second half of the seventeenth century, physiologist tried to explain fermentation by means of chemical reactions, as for instance acid -alkali, and ruled out the notion of ferment as superfluous to their investigations. At the end of hte seventeenth century fermentation attracted the interest of physicists like Johannes Bernoulli and Isaac Newton, who tried to explain fermentative processes in terms of matter and motion (Bernoulli) and short-range forces (Newton). George Ernst Stahl devoted a work to fermentation: the Zymotechnia. He explained fermentation as the outcome of the reactions of molecules formed of saline, oily and earthy corpuscles with particles of water. He saw fermentation as a mechanical process, i.e. as collision of different kinds of corpuscles.

  2. Rudbeck's complaint: a 17th-century Latin letter relating to basic immunology.

    PubMed

    Ambrose, C T

    2007-10-01

    Basic immunology can be said to have its origin in the mid-17th-century with the discovery of the peripheral lymphatics. They completed the gross anatomical picture of the lymphatic system, which is the basis for much of the immune response. Their recognition almost simultaneously by two Scandinavian anatomists led to a protracted war of words over priority of discovery, pitting a young Swedish medical student (Olof Rudbeck) against an honored Danish anatomy professor (Thomas Bartholin). In a 752-word letter in Latin, Rudbeck charged Bartholin with pre-dating a key observation, thereby giving priority of discovery to the latter. The purpose of this paper is to provide an English translation of this accusatory letter. It is a notable document in basic immunology, for it cites much of the knowledge then current in the field. And by raising the issue of priority, the letter indirectly piqued the interest of the scientific community in the lymphatic system and hastened its study. Examining the system's various functions in health and disease led to this new discipline.

  3. A shift in the spatial pattern of Iberian droughts during the 17th century

    NASA Astrophysics Data System (ADS)

    Domínguez-Castro, F.; García-Herrera, R.; Ribera, P.; Barriendos, M.

    2010-09-01

    In this paper, series of drought occurrence and drought extension in the Iberian Peninsula are constructed for the 1600-1750 period from seven rogation series. These rogation ceremony records come from Bilbao, Catalonia, Zamora, Zaragoza, Toledo, Murcia and Seville. They are distributed across the Peninsula and include the areas with the most characteristic Iberian climate types, influenced by the Atlantic and the Mediterranean conditions, described from modern data. A seasonal division of the series shows that spring is a critical season for rogation series in most of Iberia, being Bilbao the only site were the highest number of rogations is detected for a different season. The annual analysis of the series shows a dramatic difference between the first half of the 17th century when droughts are characterized by its local character; and the rest of the period, when they affect to broader regions or even to the whole Peninsula. The analysis of spring series confirms the existence of the two periods detected in the annual analysis. Finally, secondary documentary sources are used to further characterise the two most extended droughts in the period, 1664 and 1680, and to verify the extension of the areas affected by droughts recorded through rogation series.

  4. Equatorial All Sky Imager Images from the Seychelles during the March 17th, 2015 geomagnetic storm.

    NASA Astrophysics Data System (ADS)

    Curtis, B.

    2015-12-01

    An all sky imager was installed in the Seychelles earlier this year. The Seychelles islands are located northeast of Madagascar and east of Somalia in the equatorial Indian Ocean. The all sky imager is located on the island of Mahe (4.6667°S, 55.4667°E geographic), (10.55°S, 127.07°E geomagnetic), with filters of 557.7, 620.0, 630.0, 765.0 and 777.4 nm. Images with a 90 second exposure from Seychelles in 777.4nm and 630.0nm from the night before and night of the March 17th geomagnetic storm are discussed in comparison to solar wind measurements at ACE and the disturbance storm time (Dst) index. These images show line-of-sight intensities of photons received dependent on each filters wavelength. A time series of these images sometimes will show the movement of relatively dark areas, or depletions, in each emission. The depletion regions are known to cause scintillation in GPS signals. The direction and speed of movement of these depletions are related to changes observed in the solar wind.

  5. A summary of ground motion effects at SLAC (Stanford Linear Accelerator Center) resulting from the Oct 17th 1989 earthquake

    SciTech Connect

    Ruland, R.E.

    1990-08-01

    Ground motions resulting from the October 17th 1989 (Loma Prieta) earthquake are described and can be correlated with some geologic features of the SLAC site. Recent deformations of the linac are also related to slow motions observed over the past 20 years. Measured characteristics of the earthquake are listed. Some effects on machine components and detectors are noted. 18 refs., 16 figs.

  6. The "System of Chymists" and the "Newtonian Dream" in Greek-Speaking Communities in the 17th-18th Centuries

    ERIC Educational Resources Information Center

    Bokaris, Efthymios P.; Koutalis, Vangelis

    2008-01-01

    The acceptance of new chemical ideas, before the Chemical Revolution of Lavoisier, in Greek-speaking communities in the 17th and 18th centuries did not create a discourse of chemical philosophy, as it did in Europe, but rather a "philosophy" of chemistry as it was formed through the evolution of didactic traditions of Chemistry. This…

  7. The "System of Chymists" and the "Newtonian Dream" in Greek-Speaking Communities in the 17th-18th Centuries

    ERIC Educational Resources Information Center

    Bokaris, Efthymios P.; Koutalis, Vangelis

    2008-01-01

    The acceptance of new chemical ideas, before the Chemical Revolution of Lavoisier, in Greek-speaking communities in the 17th and 18th centuries did not create a discourse of chemical philosophy, as it did in Europe, but rather a "philosophy" of chemistry as it was formed through the evolution of didactic traditions of Chemistry. This…

  8. 76 FR 70178 - Investment Advisers Act of 1940; In the Matter of Creative Investment Research, Inc., 1050 17th...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-10

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Investment Advisers Act of 1940; In the Matter of Creative Investment Research, Inc., 1050 17th Street NW., Suite 1000, Washington, DC 20036; Notice of Intention to Cancel Registration Pursuant to...

  9. Assessment of soil-gas contamination at the 17th Street landfill, Fort Gordon, Georgia, 2011

    USGS Publications Warehouse

    Falls, W. Fred; Caldwell, Andral W.; Guimaraes, Wladmir G.; Ratliff, W. Hagan; Wellborn, John B.; Landmeyer, James E.

    2012-01-01

    Assessments of contaminants in soil gas were conducted in two study areas at Fort Gordon, Georgia, in July and August of 2011 to supplement environmental contaminant data for previous studies at the 17th Street landfill. The two study areas include northern and eastern parts of the 17th Street landfill and the adjacent wooded areas to the north and east of the landfill. These study areas were chosen because of their close proximity to the surface water in Wilkerson Lake and McCoys Creek. A total of 48 soil-gas samplers were deployed for the July 28 to August 3, 2011, assessment in the eastern study area. The assessment mostly identified detections of total petroleum hydrocarbons (TPH), and gasoline- and diesel-range compounds, but also identified the presence of chlorinated solvents in six samplers, chloroform in three samplers, 2-methyl naphthalene in one sampler, and trimethylbenzene in one sampler. The TPH masses exceeded 0.02 microgram (μg) in all 48 samplers and exceeded 0.9 μg in 24 samplers. Undecane, one of the three diesel-range compounds used to calculate the combined mass for diesel-range compounds, was detected in 17 samplers and is the second most commonly detected compound in the eastern study area, exceeded only by the number of TPH detections. Six samplers had detections of toluene, but other gasoline compounds were detected with toluene in three of the samplers, including detections of ethylbenzene, meta- and para-xylene, and octane. All detections of chlorinated organic compounds had soil-gas masses equal to or less than 0.08 μg, including three detections of trichloroethene, three detections of perchloroethene, three chloroform detections, one 1,4-dichlorobenzene detection, and one 1,1,2-trichloroethane detection. Three methylated compounds were detected in the eastern study area, but were detected at or below method detection levels. A total of 32 soil-gas samplers were deployed for the August 11–24, 2011, assessment in the northern study

  10. The Tsunami Generated by the October 17th, 2015 Taan Fjord landslide

    NASA Astrophysics Data System (ADS)

    Lynett, P. J.; Weiss, R.; Mattox, A.; Skanavis, V.; Ayca, A.; Tang, H.; Higman, B. M.; Stark, C. P.; Keen, A.

    2016-12-01

    On October 17th, 2015, the largest landslide in North America in decades occurred in Taan Fjord, an arm of southeast Alaska's Icy Bay. The landslide triggered an enormous local tsunami. Flow indicators from satellite imagery suggest that the maximum tsunami runup immediately adjacent to the slide mass exceeds 190 m. Such a maximum runup would be second only to that created by the 1958 Lituya Bay landslide, a poorly recorded (by modern standards) event that is nonetheless the most important dataset for understanding extreme landslide tsunami hazards available to the engineering community. From numerical simulations and reconnaissance trips, we see widespread areas where the tsunami runup exceeds 100 meters in elevation. Furthermore, at least 90% of the 50 km of shoreline in the Fjord appears to have experienced runup elevations greater than 20 m.. With these large elevations comes large inundation distances. Often, the runup limit penetrated 10's to 100's of meters into dense brush and forest. Furthermore, along the edges of the trimlines, there was often a 3m+ high pile of debris consisting mostly of trees (see Figure). All of these factors make the tools of a common tsunami field survey - a laser rangefinder and a survey rod - effectively useless. Owing to this extreme runup and inundation distances, as well as the remote location, the team used a high-accuracy Real Time Kinematic (RTK) survey system, which provides 10-cm accuracy location elevations, after the data is tide-corrected. The types of data to be presented include the most-important runup elevations, flow depth profiles, areas of sediment scour and deposition, debris piles, and the impact of the tsunami on various types of vegetation.

  11. Plastic surgery in 17th century Europe. case study: Nicolae Milescu, the snub-nosed.

    PubMed

    Dumbravă, Daniela; Luchian, Stefan

    2013-01-01

    The rising and the existence of plastic and aesthetic surgery in early modern Europe did not have a specific pattern, but was completely different from one nation to another. Colleges of Physicians could only be found in some places in Europe; different Parliaments of Europe's nations did not always elevate being a surgeon to the dignity of a profession, and being a surgeon did not always come with corporate and municipal privileges, or with attractive stipends. Conversely, corporal punishments for treacherous surgeons were ubiquitous. Rhinoplasty falls into the category of what Ambroise Paré named "facial plastic surgery". The technique is a medical source from which many histories derive, one more fascinating than the other: the history of those whose nose was cut off (because of state betrayal, adultery, abjuration, or duelling with swords), the history of those who invented the surgery of nose reconstruction (e.g. SuSruta-samhita or Tagliacozzi?), the history of surgeries kept secret in early modern Europe (e.g. Tropea, Calabria, Leiden, Padua, Paris, Berlin), and so on. Where does the history of Nicolae Milescu the Snub-nosed fall in all of this? How much of this history do the Moldavian Chronicles record? Is there any "scholarly gossip" in the aristocratic and diplomatic environments at Constantinople? What exactly do the British ambassadors learn concerning Rhinoplasty when they meet Milescu? How do we "walk" within these histories, and why should we be interested at all? What is their stike for modernity? Such are the interrogations that this article seeks to provoke; its purpose is to question (and eventually, synchronise) histories, and not exclusively history, both in academic terms but also by reassessing the practical knowledge of the 17th century.

  12. Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

    PubMed

    Colomer, R; Lupu, R; Papadimitropoulou, A; Vellón, L; Vázquez-Martín, A; Brunet, J; Fernández-Gutiérrez, A; Segura-Carretero, A; Menéndez, J A

    2008-01-01

    We are accumulating evidence to suggest that 17(th) century Renaissance foodways -largely based on the old "Mediterranean dietary traditions"- may provide new nutraceutical management strategies against HER2-positive breast cancer disease in the 21st century. Epidemiological and experimental studies begin to support the notion that "The Sacred Law of Salads" (i.e., "raw vegetables... plenty of generous (olive) oil") -originally proposed in 1614 by Giacomo Castelvetro in its book The Fruit, Herbs & Vegetables of Italy- might be considered the first (unintended) example of customised diets for breast cancer prevention based on individual genetic make-up (i.e., nutraceuticals against human breast carcinomas bearing HER2 oncogene amplification/overexpression). First, the so-called salad vegetables dietary pattern (i.e., a high consumption of raw vegetables and olive oil) appears to exert a protective effect mostly confined to the HER2-positive breast cancer subtype, with no significant influence on the occurrence of HER2-negative breast cancers. Second, all the main olive oil constituents (i.e., the omega-9 monounsaturated fatty acid oleic acid and polyphenolic compounds such as the secoiridoid oleuropein or the lignan 1-[+]-acetoxypinoresinol) dramatically reduce HER2 expression and specifically induce apoptotic cell death in cultured HER2- positive breast cancer cells, with marginal effects against HER2-negative cells. Third, an olive oil-rich diet negatively influences experimental mammary tumorigenesis in rats likewise decreasing HER2 expression levels. If early 1600s Castelvetro's salads can be used as dietary protocols capable to protecting women against biologically aggressive HER2-positive breast cancer subtypes is an intriguing prospect that warrants to be evaluated in human pilot studies in the future. Here, at least, we would like to recognise Giacomo Castelvetro as the father of modern nutritional genomics in oncology.

  13. FOREWORD: 17th National Conference of the Australian Meteorological and Oceanographic Society

    NASA Astrophysics Data System (ADS)

    Burns, Barbara A.; Davis, Clem; Kiss, Andrew E.; Taylor, John R.

    2010-05-01

    The Australian Meteorology and Oceanography Society (AMOS) has held an annual conference each year since 1994. The venue for the 17th conference in this series was the Australian National University (ANU) in Canberra, Australia's capital city. The conference ran over three days from 27 to 29 January 2010. The conference title was Atmospheres, Oceans, Environment and Society with the conference themes: Weather, ocean and climate forecasting Observing and modelling the integrated earth system Climate trends, variability and extremes: past, present and future Climate impacts and adaptation Antarctic weather, ocean and climate systems Ocean systems and dynamics. Local co-hosts for the conference were the Fenner School of Environment and Society (ANU) and the Research School of Earth Sciences (ANU). The conference organising committee was drawn from the members of the Australian Capital Territory centre of AMOS. The conference was very successful, attracting 300 delegates presenting 160 oral and 68 poster presentations over the three days. In a first for an AMOS National Conference, the organisers decided to produce a refereed Conference Proceedings with all presenters being invited to contribute. Each submitted paper was refereed by two anonymous reviewers selected by the conference editorial committee. The refereeing process followed the guidelines for the IOP Conference Series: Earth and Environmental Science. The result is the collection of 39 papers in this conference volume. The range of subjects covered in the papers reflects the diversity of the presentations prompted by the conference themes and the broad range of the research interests of the Australian climate, meteorology and oceanographic community. Within the proceedings the editors have presented the papers alphabetically within the theme area in which they were presented at the conference. The editorial committee wish to thank not only the authors for their contributions to this volume but also the

  14. gLExec: gluing grid computing to the Unix world

    NASA Astrophysics Data System (ADS)

    Groep, D.; Koeroo, O.; Venekamp, G.

    2008-07-01

    The majority of compute resources in todays scientific grids are based on Unix and Unix-like operating systems. In this world, user and user-group management are based around the concepts of a numeric 'user ID' and 'group ID' that are local to the resource. In contrast, grid concepts of user and group management are centered around globally assigned identifiers and VO membership, structures that are independent of any specific resource. At the fabric boundary, these 'grid identities' have to be translated to Unix user IDs. New job submission methodologies, such as job-execution web services, community-deployed local schedulers, and the late binding of user jobs in a grid-wide overlay network of 'pilot jobs', push this fabric boundary ever further down into the resource. gLExec, a light-weight (and thereby auditable) credential mapping and authorization system, addresses these issues. It can be run both on fabric boundary, as part of an execution web service, and on the worker node in a late-binding scenario. In this contribution we describe the rationale for gLExec, how it interacts with the site authorization and credential mapping frameworks such as LCAS, LCMAPS and GUMS, and how it can be used to improve site control and traceability in a pilot-job system.

  15. Psychotherapy Is Chaotic—(Not Only) in a Computational World

    PubMed Central

    Schiepek, Günter K.; Viol, Kathrin; Aichhorn, Wolfgang; Hütt, Marc-Thorsten; Sungler, Katharina; Pincus, David; Schöller, Helmut J.

    2017-01-01

    Objective: The aim of this article is to outline the role of chaotic dynamics in psychotherapy. Besides some empirical findings of chaos at different time scales, the focus is on theoretical modeling of change processes explaining and simulating chaotic dynamics. It will be illustrated how some common factors of psychotherapeutic change and psychological hypotheses on motivation, emotion regulation, and information processing of the client's functioning can be integrated into a comprehensive nonlinear model of human change processes. Methods: The model combines 5 variables (intensity of emotions, problem intensity, motivation to change, insight and new perspectives, therapeutic success) and 4 parameters into a set of 5 coupled nonlinear difference equations. The results of these simulations are presented as time series, as phase space embedding of these time series (i.e., attractors), and as bifurcation diagrams. Results: The model creates chaotic dynamics, phase transition-like phenomena, bi- or multi-stability, and sensibility of the dynamic patterns on parameter drift. These features are predicted by chaos theory and by Synergetics and correspond to empirical findings. The spectrum of these behaviors illustrates the complexity of psychotherapeutic processes. Conclusion: The model contributes to the development of an integrative conceptualization of psychotherapy. It is consistent with the state of scientific knowledge of common factors, as well as other psychological topics, such as: motivation, emotion regulation, and cognitive processing. The role of chaos theory is underpinned, not only in the world of computer simulations, but also in practice. In practice, chaos demands technologies capable of real-time monitoring and reporting on the nonlinear features of the ongoing process (e.g., its stability or instability). Based on this monitoring, a client-centered, continuous, and cooperative process of feedback and control becomes possible. By contrast, restricted

  16. Psychotherapy Is Chaotic-(Not Only) in a Computational World.

    PubMed

    Schiepek, Günter K; Viol, Kathrin; Aichhorn, Wolfgang; Hütt, Marc-Thorsten; Sungler, Katharina; Pincus, David; Schöller, Helmut J

    2017-01-01

    Objective: The aim of this article is to outline the role of chaotic dynamics in psychotherapy. Besides some empirical findings of chaos at different time scales, the focus is on theoretical modeling of change processes explaining and simulating chaotic dynamics. It will be illustrated how some common factors of psychotherapeutic change and psychological hypotheses on motivation, emotion regulation, and information processing of the client's functioning can be integrated into a comprehensive nonlinear model of human change processes. Methods: The model combines 5 variables (intensity of emotions, problem intensity, motivation to change, insight and new perspectives, therapeutic success) and 4 parameters into a set of 5 coupled nonlinear difference equations. The results of these simulations are presented as time series, as phase space embedding of these time series (i.e., attractors), and as bifurcation diagrams. Results: The model creates chaotic dynamics, phase transition-like phenomena, bi- or multi-stability, and sensibility of the dynamic patterns on parameter drift. These features are predicted by chaos theory and by Synergetics and correspond to empirical findings. The spectrum of these behaviors illustrates the complexity of psychotherapeutic processes. Conclusion: The model contributes to the development of an integrative conceptualization of psychotherapy. It is consistent with the state of scientific knowledge of common factors, as well as other psychological topics, such as: motivation, emotion regulation, and cognitive processing. The role of chaos theory is underpinned, not only in the world of computer simulations, but also in practice. In practice, chaos demands technologies capable of real-time monitoring and reporting on the nonlinear features of the ongoing process (e.g., its stability or instability). Based on this monitoring, a client-centered, continuous, and cooperative process of feedback and control becomes possible. By contrast, restricted

  17. Forming, transfer and globalization of medical-pharmaceutical knowledge in South East Asian missions (17th to 18th c.) - historical dimensions and modern perspectives.

    PubMed

    Anagnostou, Sabine

    2015-06-05

    From the 17th to the 18th centuries, missionaries in Southeast Asia dedicated themselves to providing and establishing a professional medical-pharmaceutical supply for the local population and therefore explored the genuine Materia medica for easily available and affordable remedies, especially medicinal plants. In characteristic medical-pharmaceutical compendia, which can be classified as missionary pharmacopoeias, they laid down their knowledge to advise others and to guarantee a professional health care. As their knowledge often resulted from an exchange with indigenous communities, these compendia provide essential information about traditional plant uses of Southeast Asian people. Individual missionaries such as the Jesuit Georg Joseph Kamel (1661-1706) not only strove to explore medicinal plants but performed botanical studies and even composed comprehensive herbals. The Jesuit missionaries in particular played roles in both the order's own global network of transfer of medicinal drugs and knowledge about the application, and within the contemporary local and European scientific networks which included, for example, the famous Royal Society of London. The results of their studies were distributed all over the world, were introduced into the practical Materia medica of other regions, and contributed significantly to the academization of knowledge. In our article we will explain the different intentions and methods of exploring, the resulting works and the consequences for the forming of the pharmaceutical and scientific knowledge. Finally, we will show the options which the works of the missionaries can offer for the saving of traditional ethnopharmacological knowledge and for the development of modern phytotherapeutics and pharmaceutical supply. The publication is based on a comprehensive study on the phenomenon of missionary pharmacy which has been published as a book in 2011 (Anagnostou, 2011a) and shows now the potential of historical medical

  18. Analysis the flash floods occurred in the South Tyne river watershed (United Kingdom) on the 17th of July 2007

    NASA Astrophysics Data System (ADS)

    Bain, V.; Milan, D.; Preciso, E.; Gaume, E.

    2009-04-01

    On the 17th, 19th and 23rd of July 2007, a series of local thunderstorms induced flash floods in the upper part of the South Tyne river in Northumberland, a rural area located near the border between England and Scotland. These events led to moderate damages in the villages and losses of livestock in local farms. They were shadowed in comparison to the widespread lowland floods that occurred throughout the UK during the same period but were nevertheless extreme events for the region. One of the affected streams, the Thinhope Burn, has been surveyed by the University of Gloucestershire during recent years. It is an active river from a geomorphological point of view. A survey conducted after the 2007 flood revealed that many of the boulders along the banks of the river, which had been deposited 50 to 100 years before, had been displaced, indicating a high return period for the flood (see EGU abstract EGU2008-A-04713). A complementary survey was conducted in July 2008 with the objective of gathering information on the discharges, the rainfall amounts and the active runoff processes. 14 cross-sections were surveyed, pictures were collected enabling a validation of peak discharge estimates, 5 witnesses were interviewed and additional rainfall data and geomorphological evidence were collected. This survey revealed that the peak discharges exceeded 5 m3/s/km2 in the most affected areas. Unfortunately, no rainfall measurements are available that would enable further analysis, including the computation of runoff rates. Nevertheless, witness accounts and field observations give a good insight into the hydrological processes indicating a significant initial storage capacity of the peat layer covering the affected watersheds. Concerning the boulders, the field observations suggest surprising and unexplained transport processes. Blocks of up to one meter diameter were displaced over short distances and deposited on the river banks without any sign of established debris flow, as

  19. [The apothecaries of the quartier de la Harpe in Paris in the 16th and 17th centuries].

    PubMed

    Warolin, Christian

    2015-09-01

    Large families of apothecaries, some of them very famous, lived in the Quartier de la Harpe in Paris, on the left bank of Seine, from the 16th to the 17th century. The study confirms a well-established fact that apothecaries practised endogamy, in others words marriage within the same social class. The biographical research includes ten apothecaries, most of whom lived in the rue Saint-André-des-Arts.

  20. Tropical mathematics and the financial catastrophe of the 17th century. Thermoeconomics of Russia in the early 20th century

    NASA Astrophysics Data System (ADS)

    Maslov, V. P.

    2010-03-01

    In the paper, an example is presented concerning relationships (which cannot be neglected) between mathematics and other sciences. In particular, the relationship between the tropical mathematics and the humanitarian-economic catastrophe of 17th century (related to slavery of Africans) is considered. The notion of critical state of economy of the 19th century is introduced by using the refined Fisher equation. A correspondence principle for thermodynamics of fluids and economics of the 19th century is presented.

  1. A Hard Look at the World of Educational Computing.

    ERIC Educational Resources Information Center

    Grady, David

    1982-01-01

    Addresses various issues in educational computing, suggesting that the real crisis facing schools is not a software shortage but a hardware crunch accompanied by misconceptions about how computers can help children learn. (Author/JN)

  2. Epilepsy in the Renaissance: a survey of remedies from 16th and 17th century German herbals.

    PubMed

    Adams, Michael; Schneider, Sarah-Vanessa; Kluge, Martin; Kessler, Michael; Hamburger, Matthias

    2012-08-30

    Before modern anticonvulsive drugs were developed people in central Europe used herbal remedies to treat epilepsy. Hundreds of different plants for this indication can be found in German herbals of the 16th and 17th centuries. Here we compile these plants and discuss their use from a pharmacological perspective. Nine of the most important European herbals of the 16th and 17th century including Bock (1577), Fuchs (1543), Mattioli (1590), Lonicerus (1660, 1770), Brunfels (1532), Zwinger (1696), and Tabernaemontanus (1591, 1678) were searched for terms related to epilepsy, and plants and recipes described for its treatment were documented. We then searched scientific literature for pharmacological evidence of their effectiveness. Additionally the overlapping of these remedies with those in De Materia Medica by the Greek physician Dioscorides was studied. Two hundred twenty one plants were identified in the herbals to be used in the context of epilepsy. In vitro and/or in vivo pharmacological data somehow related to the indication epilepsy was found for less than 5% of these plants. Less than 7% of epilepsy remedies are in common with De Materia Medica. Numerous plants were used to treat epilepsy in the 16th and 17th centuries. However, few of these plants have been investigated with respect to pharmacological activity on epilepsy related targets. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Welcome to the World of Computers. Part 1.

    ERIC Educational Resources Information Center

    Education Service Center Region 20, San Antonio, TX.

    This manual was developed to help adult education teachers teach their students about computers as part of other courses in English, mathematics, social studies, or in a computer literacy course. Much of the manual has been written so that instruction can be given with or without the use of a computer. Although the manual is designed for use by…

  4. Transportation for the Mind: Computers in the World of 1985.

    ERIC Educational Resources Information Center

    Jennings, Lane

    1984-01-01

    Discusses developments in computer technology--touch screen controls, the joystick, the mouse, voice synthesis, and speech recognition--which are making computers more acceptable to and usable by the general public. Also discusses applications in the appliance, automobile, health, and robotics fields which are making computers ever more important…

  5. PREFACE: 17th International Conference on Recent Progress in Many-Body Theories (MBT17)

    NASA Astrophysics Data System (ADS)

    Reinholz, Heidi; Boronat, Jordi

    2014-08-01

    These are the proceedings of the XVII International Conference on Recent Progress in Many-Body Theories, which was held from 8-13 September 2013 in Rostock, Germany. The conference continued the triennial series initiated in Trieste in 1978 and was devoted to new developments in the field of many-body theories. The conference series encourages the exchange of ideas between physicists working in such diverse areas as nuclear physics, quantum chemistry, lattice Hamiltonians or quantum uids. Many-body theories are an integral part in different fields of theoretical physics such as condensed matter, nuclear matter and field theory. Phase transitions and macroscopic quantum effects such as magnetism, Bose-Einstein condensation, super uidity or superconductivity have been investigated within ultra-cold gases, finite systems or various nanomaterials. The conference series on Recent Progress in Many-Body Theories is devoted to foster the interaction and to cross-fertilize between different fields and to discuss future lines of research. The topics of the 17th meeting were Cluster Physics Cold Gases High Energy Density Matter and Intense Lasers Magnetism New Developments in Many-Body Techniques Nuclear Many-Body and Relativistic Theories Quantum Fluids and Solids Quantum Phase Transitions Topological Insulators and Low Dimensional Systems. 109 participants from 20 countries participated. 44 talks and 61 posters werde presented. As a particular highlight of the conference, The Eugene Feenberg Memorial Medal for outstanding results in the field of many-body theory and The Hermann Kümmel Early Achievement Award in Many-Body Physics for young scientists in that field were awarded. The Feenberg Medal went jointly to Patrick Lee (MIT, USA) for his fundamental contributions to condensed-matter theory, especially in regard to the quantum Hall effect, to universal conductance uctuations, and to the Kondo effect in quantum dots, and Douglas Scalapino (UC Santa Barbara, USA) for his

  6. [Effects of the periodical spread of rinderpest on famine, epidemic, and tiger disasters in the late 17th Century].

    PubMed

    Kim, Dong Jin; Yoo, Han Sang; Lee, Hang

    2014-04-01

    This study clarifies the causes of the repetitive occurrences of such phenomena as rinderpest, epidemic, famine, and tiger disasters recorded in the Joseon Dynasty Chronicle and the Seungjeongwon Journals in the period of great catastrophe, the late 17th century in which the great Gyeongsin famine (1670~1671) and the great Eulbyeong famine (1695~1696) occurred, from the perspective that they were biological exchanges caused by the new arrival of rinderpest in the early 17th century. It is an objection to the achievements by existing studies which suggest that the great catastrophes occurring in the late 17th century are evidence of phenomena in a little ice age. First of all, rinderpest has had influence on East Asia as it had been spread from certain areas in Machuria in May 1636 through Joseon, where it raged throughout the nation, and then to the west part of Japan. The new arrival of rinderpest was indigenized in Joseon, where it was localized and spread periodically while it was adjusted to changes in the population of cattle with immunity in accordance with their life spans and reproduction rates. As the new rinderpest, which showed high pathogenicity in the early 17th century, was indigenized with its high mortality and continued until the late 17th century, it broke out periodically in general. Contrastively, epidemics like smallpox and measles that were indigenized as routine ones had occurred constantly from far past times. As a result, the rinderpest, which tried a new indigenization, and the human epidemics, which had been already indigenized long ago, were unexpectedly overlapped in their breakout, and hence great changes were noticed in the aspects of the human casualty due to epidemics. The outbreak of rinderpest resulted in famine due to lack of farming cattle, and the famine caused epidemics among people. The casualty of the human population due to the epidemics in turn led to negligence of farming cattle, which constituted factors that triggered

  7. Application of computational aero-acoustics to real world problems

    NASA Technical Reports Server (NTRS)

    Hardin, Jay C.

    1996-01-01

    The application of computational aeroacoustics (CAA) to real problems is discussed in relation to the analysis performed with the aim of assessing the application of the various techniques. It is considered that the applications are limited by the inability of the computational resources to resolve the large range of scales involved in high Reynolds number flows. Possible simplifications are discussed. It is considered that problems remain to be solved in relation to the efficient use of the power of parallel computers and in the development of turbulent modeling schemes. The goal of CAA is stated as being the implementation of acoustic design studies on a computer terminal with reasonable run times.

  8. Application of computational aero-acoustics to real world problems

    NASA Technical Reports Server (NTRS)

    Hardin, Jay C.

    1996-01-01

    The application of computational aeroacoustics (CAA) to real problems is discussed in relation to the analysis performed with the aim of assessing the application of the various techniques. It is considered that the applications are limited by the inability of the computational resources to resolve the large range of scales involved in high Reynolds number flows. Possible simplifications are discussed. It is considered that problems remain to be solved in relation to the efficient use of the power of parallel computers and in the development of turbulent modeling schemes. The goal of CAA is stated as being the implementation of acoustic design studies on a computer terminal with reasonable run times.

  9. Proceedings of the Annual Conference of Air Force Behavioral Scientists (17th),

    DTIC Science & Technology

    PSYCHIATRY, *SYMPOSIA), MILITARY PSYCHOLOGY , MENTAL DISORDERS, PERSONNEL, BEHAVIOR, THERAPY, COMPUTER PROGRAMMING, UNCERTAINTY, STRESS( PSYCHOLOGY ), TRANSFORMATIONS, ATTITUDES( PSYCHOLOGY ), ABNORMAL PSYCHOLOGY , ADDICTION, CHILDREN, FEAR

  10. An HCI Approach to Computing in the Real World

    ERIC Educational Resources Information Center

    Yardi, Sarita; Krolikowski, Pamela; Marshall, Taneshia; Bruckman, Amy

    2008-01-01

    We describe the implementation of a six-week course to teach Human-Computer Interaction (HCI) to high school students. Our goal was to explore the potential of HCI in motivating students to pursue future studies in related computing fields. Participants in our course learned to make connections between the types of technology they use in their…

  11. An HCI Approach to Computing in the Real World

    ERIC Educational Resources Information Center

    Yardi, Sarita; Krolikowski, Pamela; Marshall, Taneshia; Bruckman, Amy

    2008-01-01

    We describe the implementation of a six-week course to teach Human-Computer Interaction (HCI) to high school students. Our goal was to explore the potential of HCI in motivating students to pursue future studies in related computing fields. Participants in our course learned to make connections between the types of technology they use in their…

  12. WIRELESS Computing in Schools: Reach Out and Touch the World.

    ERIC Educational Resources Information Center

    Null, Linda; Teschner, Randy

    Many elementary and secondary schools tie with local colleges and universities and use modems to access the computing power available at these higher education facilities. To help alleviate the financial burden of long-distance phone charges, work had begun to use the airways instead of phone lines for computer communication. An interest in…

  13. The 17th International Congress on Infectious Diseases workshop on developing infection prevention and control resources for low- and middle-income countries.

    PubMed

    Sastry, Sangeeta; Masroor, Nadia; Bearman, Gonzalo; Hajjeh, Rana; Holmes, Alison; Memish, Ziad; Lassmann, Britta; Pittet, Didier; Macnab, Fiona; Kamau, Rachel; Wesangula, Evelyn; Pokharel, Paras; Brown, Paul; Daily, Frances; Amer, Fatma; Torres, Jaime; O'Ryan, Miguel; Gunturu, Revathi; Bulabula, Andre; Mehtar, Shaheen

    2017-04-01

    Hospital-acquired infections (HAIs) are a major concern to healthcare systems around the world. They are associated with significant morbidity and mortality, in addition to increased hospitalization costs. Recent outbreaks, including those caused by the Middle East respiratory syndrome coronavirus and Ebola virus, have highlighted the importance of infection control. Moreover, HAIs, especially those caused by multidrug-resistant Gram-negative rods, have become a top global priority. Although adequate approaches and guidelines have been in existence for many years and have often proven effective in some countries, the implementation of such approaches in low- and middle-income countries (LMICs) is often restricted due to limited resources and underdeveloped infrastructure. While evidence-based infection prevention and control (IPC) principles and practices are universal, studies are needed to evaluate simplified approaches that can be better adapted to LMIC needs, in order to guide IPC in practice. A group of experts from around the world attended a workshop held at the 17th International Congress on Infectious Diseases in Hyderabad, India in March 2016, to discuss the existing IPC practices in LMICs, and how best these can be improved within the local context. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  14. PREFACE: 17th International Conference on the Physics of Highly Charged Ions

    NASA Astrophysics Data System (ADS)

    2015-01-01

    The 17th edition of the International Conference on the Physics of Highly Charged Ions (HCI 2014) was held in San Carlos de Bariloche, in the southern region of Argentina known as Patagonia, from August 31 to September 5, 2014. This meeting corresponds to a series of HCI conferences, which has been held every other year since 1982 in cities in Europe, USA, Japan and China. This was the first time that the conference took place in Latin America. This edition was organized by a Local Committee made up of physicists mainly from the cities of Bariloche and Rosario and also from Buenos Aires and Bahía Blanca, all sites where research on Atomic Collisions is developed. The conference was attended by delegates coming from 18 countries, more that 23% of whom were women. The field of highly charged ions has seen in recent years a promising evolution originating from bold progress in theory and significant advances in experimental techniques. The HCI conferences aim at bringing together experimentalists and theoreticians from as wide a range of fields as, for instance, Fundamental Aspects, Structure and Spectroscopy, Collisions with Electrons, Ions, Atoms and Molecules, Interaction with Clusters, Surfaces and Solids, Interactions with Photons and Plasmas, Strong Field Processes, and Production, Experimental Developments and Applications. The Scientific Programme, selected by an International Advisory Board, included 5 Review Lectures, 11 Progress Reports, 1 Local Report and 24 Special Reports. In addition, the results of 132 contributed works were presented as poster communications and a Public Lecture on 'The wonders of the Southern Skies' was delivered by an Argentinean expert. Thus, a wide range of subjects comprising a balanced mix of topics was covered throughout the course of the conference. The HCI 2014 was a resounding success for the international and local communities, from both the scientific and social aspects, considering that the attendees and accompanying

  15. Connecting the virtual world of computers to the real world of medicinal chemistry.

    PubMed

    Glen, Robert C

    2011-03-01

    Drug discovery involves the simultaneous optimization of chemical and biological properties, usually in a single small molecule, which modulates one of nature's most complex systems: the balance between human health and disease. The increased use of computer-aided methods is having a significant impact on all aspects of the drug-discovery and development process and with improved methods and ever faster computers, computer-aided molecular design will be ever more central to the discovery process.

  16. Conference Abstracts: Fourth Annual World Conference on Computers in Education-Part II.

    ERIC Educational Resources Information Center

    Baird, William E.

    1986-01-01

    Presented are abstracts from volume two of the World Conference on Computers in Education, 1985. Four topics are: (1) cognitive and visual style; (2) computer graphics and descriptive geometry; (3) LOGO and educational research; and (4) algorithms, programing, and computer literacy. (JM)

  17. Report from the 17th Annual Western Canadian Gastrointestinal Cancer Consensus Conference; Edmonton, Alberta; 11–12 September 2015

    PubMed Central

    Mulder, K.E.; Ahmed, S.; Davies, J.D.; Doll, C.M.; Dowden, S.; Gill, S.; Gordon, V.; Hebbard, P.; Lim, H.; McFadden, A.; McGhie, J.P.; Park, J.; Wong, R.

    2016-01-01

    The 17th annual Western Canadian Gastrointestinal Cancer Consensus Conference (wcgccc) was held in Edmonton, Alberta, 11–12 September 2015. The wcgccc is an interactive multidisciplinary conference attended by health care professionals from across Western Canada (British Columbia, Alberta, Saskatchewan, and Manitoba) who are involved in the care of patients with gastrointestinal cancer. Surgical, medical, and radiation oncologists; pathologists; radiologists; and allied health care professionals participated in presentation and discussion sessions for the purposes of developing the recommendations presented here. This consensus statement addresses current issues in the management of gastric cancer. PMID:28050139

  18. Department of Defense Annual Cost Analysis Symposium (17th) Held at Arlington, Virginia on 12-15 September 1982.

    DTIC Science & Technology

    1982-09-01

    AD-A138 41S DEPARTMENT OF DEFENSE ANNUAL COST ANALYSIS SYMPOSIUM 17TH) HELD AT ARLINGTON VIRGINIA ON 12-05 SEPTEMBER 1982(U) OFFICE OF THE CHIEF OF... Virginia on 12-15 September 1982. (SOURCE): Office of the Chief of Naval Operations, Washington, DC. To ORDER THE COMPLETE COMPILATION REPORT USE AD-A130...0_ LL L 0-. I- w W W F- U) D 0 U) w w w D-A0lS 41S DEPARTMENT OF DEFENSE ANNUAL COST ANALYSIS SYMPOSIUM 216/ (1TH) HELD AT*ARLINGTON VIRGINIA ON 12-15

  19. Union catalogue of printed books of 15th, 16th and 17th centuries in European astronomical observatories.

    NASA Astrophysics Data System (ADS)

    Grassi, G.

    This catalogue deals with the scientific subjects of that historical period such as astronomy, astrology, chemistry, mathematics, physics, historia naturalis and so forth, and contains extremely rare volumes such as the first printed editions of the eminent Arab, Latin, Greek and Persian scientists Albumasar, Albohazen Aly, Aristoteles, Ptolemaeus, Pliny the Elder and Ulugh Beig. In addition the catalogue contains the first works of such great astronomers of the 16th and 17th centuries as Copernicus, Kepler, Clavius, Regiomontanus, Sacrobosco, Mercator, Newton, Gassendi, Galilei and Hevelius, just to quote the most representative ones. The catalogue is followed by a chronological index and an index of printers and publishers.

  20. Report from the 17th Annual Western Canadian Gastrointestinal Cancer Consensus Conference; Edmonton, Alberta; 11-12 September 2015.

    PubMed

    Mulder, K E; Ahmed, S; Davies, J D; Doll, C M; Dowden, S; Gill, S; Gordon, V; Hebbard, P; Lim, H; McFadden, A; McGhie, J P; Park, J; Wong, R

    2016-12-01

    The 17th annual Western Canadian Gastrointestinal Cancer Consensus Conference (wcgccc) was held in Edmonton, Alberta, 11-12 September 2015. The wcgccc is an interactive multidisciplinary conference attended by health care professionals from across Western Canada (British Columbia, Alberta, Saskatchewan, and Manitoba) who are involved in the care of patients with gastrointestinal cancer. Surgical, medical, and radiation oncologists; pathologists; radiologists; and allied health care professionals participated in presentation and discussion sessions for the purposes of developing the recommendations presented here. This consensus statement addresses current issues in the management of gastric cancer.

  1. Conference Overview: 17th Biennial Conference on Chemical Education, Western Washington University, July 28-August 1, 2002

    NASA Astrophysics Data System (ADS)

    Kriz, George S.; Selfe, Sara

    2002-06-01

    This article describes the 17th Biennial Conference on Chemical Education, to be held from July 28 through August 1, 2002, at Western Washington University, Bellingham, Washington. The paper outlines important features of the conference program, including workshops, Plenary Lectures, symposia, and poster sessions. Special program highlights are also identified. Other features of the conference, including exhibits, conference banquet, and travel information are included. Details regarding conference regisration and application for housing and meals are provided. A list of sponsoring organizations and companies may also be found.

  2. Clinical practice in a computer world: considering the issues.

    PubMed

    Hughes, Rhidian A

    2003-05-01

    In an era when information technology developments are being harnessed by governments to improve patient care, it is important to consider the issues raised by the use of computers in health care practice and policy. The aim of this paper is to provide an appraisal of considerations raised by the use of computers in health care. REVIEW FOCUS: Drawing on a range of studies in the social and medical sciences, the paper reviews the considerations. The introduction to the paper maps out the policy context, which is followed by three substantive sections: first, computer hardware and software considerations; second, issues around confidentiality; and third, personal, social and cultural considerations. This paper demonstrates that information technology developments must be allied with government or state direction and should be informed by evidence. Whilst the issues discussed are of primary relevance to the United Kingdom National Health Service, they have wider relevance to health care systems internationally.

  3. Programs=data=first-class citizens in a computational world.

    PubMed

    Jones, Neil D; Simonsen, Jakob Grue

    2012-07-28

    From a programming perspective, Alan Turing's epochal 1936 paper on computable functions introduced several new concepts, including what is today known as self-interpreters and programs as data, and invented a great many now-common programming techniques. We begin by reviewing Turing's contribution from a programming perspective; and then systematize and mention some of the many ways that later developments in models of computation (MOCs) have interacted with computability theory and programming language research. Next, we describe the 'blob' MOC: a recent stored-program computational model without pointers. In the blob model, programs are truly first-class citizens, capable of being automatically compiled, or interpreted, or executed directly. Further, the blob model appears closer to being physically realizable than earlier computation models. In part, this is due to strong finiteness owing to early binding in the program; and a strong adjacency property: the active instruction is always adjacent to the piece of data on which it operates. The model is Turing complete in a strong sense: a universal interpretation algorithm exists that is able to run any program in a natural way and without arcane data encodings. Next, some of the best known among the numerous existing MOCs are described, and we develop a list of traits an 'ideal' MOC should possess from our perspective. We make no attempt to consider all models put forth since Turing's 1936 paper, and the selection of models covered concerns only models with discrete, atomic computation steps. The next step is to classify the selected models by qualitative rather than quantitative features. Finally, we describe how the blob model differs from an 'ideal' MOC, and identify some natural next steps to achieve such a model.

  4. Experiments in a Perfect World:. Computer Simulations of Growth

    NASA Astrophysics Data System (ADS)

    Jensen, Pablo; Larralde, Hernán

    We present two examples of computer simulations which can give unique information on the growth mechanisms of nanostructures and thin films. First, the morphologies and the island size distributions in the usual epitaxial growth models are studied. This information cannot be obtained from simple analytical approaches such as mean-field calculations or scaling analysis. Second, we analyze a new model which includes monomer evaporation and we show that computer simulations can help deciding between different mean-field analysis and lead to the correct growth exponents.

  5. Welcome to the World of Computers. Part 2.

    ERIC Educational Resources Information Center

    Education Service Center Region 20, San Antonio, TX.

    A continuation of an earlier manual, this guide was written to help adult education teachers and their students to go beyond the information of part 1 and learn more about the uses of computers. Although this manual is directed more toward teachers and administrators than toward students, activities for students are provided. As in part 1, some of…

  6. War of ontology worlds: mathematics, computer code, or Esperanto?

    PubMed

    Rzhetsky, Andrey; Evans, James A

    2011-09-01

    The use of structured knowledge representations-ontologies and terminologies-has become standard in biomedicine. Definitions of ontologies vary widely, as do the values and philosophies that underlie them. In seeking to make these views explicit, we conducted and summarized interviews with a dozen leading ontologists. Their views clustered into three broad perspectives that we summarize as mathematics, computer code, and Esperanto. Ontology as mathematics puts the ultimate premium on rigor and logic, symmetry and consistency of representation across scientific subfields, and the inclusion of only established, non-contradictory knowledge. Ontology as computer code focuses on utility and cultivates diversity, fitting ontologies to their purpose. Like computer languages C++, Prolog, and HTML, the code perspective holds that diverse applications warrant custom designed ontologies. Ontology as Esperanto focuses on facilitating cross-disciplinary communication, knowledge cross-referencing, and computation across datasets from diverse communities. We show how these views align with classical divides in science and suggest how a synthesis of their concerns could strengthen the next generation of biomedical ontologies.

  7. Security Meets Real-World Computing. Building Digital Libraries

    ERIC Educational Resources Information Center

    Huwe, Terence K.

    2005-01-01

    The author of this column describes several instances in which secure data on computers were compromised. In each of these instances, a different route was involved in gaining access to the secure data--one by office-based theft, one by hacking, and one by burglary. Is is proposed that the most difficult factor to guarantee in the protection of…

  8. War of Ontology Worlds: Mathematics, Computer Code, or Esperanto?

    PubMed Central

    Rzhetsky, Andrey; Evans, James A.

    2011-01-01

    The use of structured knowledge representations—ontologies and terminologies—has become standard in biomedicine. Definitions of ontologies vary widely, as do the values and philosophies that underlie them. In seeking to make these views explicit, we conducted and summarized interviews with a dozen leading ontologists. Their views clustered into three broad perspectives that we summarize as mathematics, computer code, and Esperanto. Ontology as mathematics puts the ultimate premium on rigor and logic, symmetry and consistency of representation across scientific subfields, and the inclusion of only established, non-contradictory knowledge. Ontology as computer code focuses on utility and cultivates diversity, fitting ontologies to their purpose. Like computer languages C++, Prolog, and HTML, the code perspective holds that diverse applications warrant custom designed ontologies. Ontology as Esperanto focuses on facilitating cross-disciplinary communication, knowledge cross-referencing, and computation across datasets from diverse communities. We show how these views align with classical divides in science and suggest how a synthesis of their concerns could strengthen the next generation of biomedical ontologies. PMID:21980276

  9. Are Computer Science Students Ready for the Real World.

    ERIC Educational Resources Information Center

    Elliot, Noreen

    The typical undergraduate program in computer science includes an introduction to hardware and operating systems, file processing and database organization, data communication and networking, and programming. However, many graduates may lack the ability to integrate the concepts "learned" into a skill set and pattern of approaching problems that…

  10. Security Meets Real-World Computing. Building Digital Libraries

    ERIC Educational Resources Information Center

    Huwe, Terence K.

    2005-01-01

    The author of this column describes several instances in which secure data on computers were compromised. In each of these instances, a different route was involved in gaining access to the secure data--one by office-based theft, one by hacking, and one by burglary. Is is proposed that the most difficult factor to guarantee in the protection of…

  11. Teaching World History With Computers: Why Do I Do It and What's Involved.

    ERIC Educational Resources Information Center

    Tucker, Sara W.

    2002-01-01

    Identifies reasons for using computers to teach world history. Discusses how instructors can acquire and use digital classroom resources. Describes how to develop and use online courses and course Web pages. (PAL)

  12. Teaching World History With Computers: Why Do I Do It and What's Involved.

    ERIC Educational Resources Information Center

    Tucker, Sara W.

    2002-01-01

    Identifies reasons for using computers to teach world history. Discusses how instructors can acquire and use digital classroom resources. Describes how to develop and use online courses and course Web pages. (PAL)

  13. [The debate on the generation of imperfect plants in the 17th and 18th centuries].

    PubMed

    Ottaviani, Alessandro

    2003-01-01

    18th-century discussions on the generation of imperfect plants were often linked with the question of their position in the natural world, namely as whether they were part of the vegetable or mineral realm. As attested by the work of Joseph Gaertner, Johann Jakob Dillen, Pier Antonio Micheli and René-Antoine Ferchault de Réaumur, as well as of Antonio Vallisneri, and Lazzaro Spallanzani, the different images of nature - continuity and discontinuity - adopted by naturalists influenced their solution to this question.

  14. Discovery of taeniid eggs from a 17th century tomb in Korea.

    PubMed

    Lee, Hye-Jung; Shin, Dong-Hoon; Seo, Min

    2011-09-01

    Even though Taenia spp. eggs are occasionally discovered from archeological remains around the world, these eggs have never been discovered in ancient samples from Korea. When we attempted to re-examine the archeological samples maintained in our collection, the eggs of Taenia spp., 5 in total number, were recovered from a tomb of Gongju-si. The eggs had radially striated embryophore, and 37.5-40.0 µm×37.5 µm in size. This is the first report on taeniid eggs from ancient samples of Korea, and it is suggested that intensive examination of voluminous archeological samples should be needed for identification of Taenia spp.

  15. Improving Teaching and Learning of Computer Programming through the Use of the Second Life Virtual World

    ERIC Educational Resources Information Center

    Esteves, Micaela; Fonseca, Benjamim; Morgado, Leonel; Martins, Paulo

    2011-01-01

    The emergence of new technologies such as three-dimensional virtual worlds brings new opportunities for teaching and learning. We conducted an action research approach to the analysis of how teaching and learning of computer programming at the university level could be developed within the Second Life virtual world. Results support the notion that…

  16. Chitinase Expression Due to Reduction in Fusaric Acid Level in an Antagonistic Trichoderma harzianum S17TH.

    PubMed

    Sharma, Vivek; Bhandari, Pamita; Singh, Bikram; Bhatacharya, Amita; Shanmugam, Veerubommu

    2013-06-01

    To study the effect of reduction in phytotoxin level on fungal chitinases, antagonistic Trichoderma spp. were screened for their ability to reduce the level of fusaric acid (FA), the phytotoxin produced by Fusarium spp. A T. harzianum isolate S17TH was able to tolerate high levels of FA (up to 500 ppm) but was unable to reduce the toxin to a significant level (non-toxic) added to minimal synthetic broth (MSB). However, the isolate was able to reduce 400 ppm FA in the liquid medium after 7 days to a non-toxic level and displayed similar level of antagonism over the control (without FA). In studies of the effect of the reduction in FA (400 ppm) level on chitinase gene expression in PCR assays, nag1 was significantly repressed but ech42 expression was only slightly repressed. Chitinase activity was either reduced or absent in the extracellular proteins of MSB supplemented with 400 ppm FA, which could be attributed to the effect of residual FA or its breakdown products through unknown mechanisms. Selection of S17TH as a toxin insensitive isolate that could commensurate the negative effect on chitinase activity makes it a potential antagonist against Fusarium spp.

  17. JANNAF 28th Propellant Development and Characterization Subcommittee and 17th Safety and Environmental Protection Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Mulder, Edwin J. (Editor); Gomez-Knight, Sylvia J. (Editor)

    1999-01-01

    This volume contains 37 unclassified/unlimited-distribution technical papers that were presented at the JANNAF 28th Propellant Development & Characterization Subcommittee (PDCS) and 17th Safety & Environmental Protection Subcommittee (S&EPS) Joint Meeting, held 26-30 April 1999 at the Town & Country Hotel and the Naval Submarine Base, San Diego, California. Volume II contains 29 unclassified/limited-distribution papers that were presented at the 28th PDCS and 17th S&EPS Joint Meeting. Volume III contains a classified paper that was presented at the 28th PDCS Meeting on 27 April 1999. Topics covered in PDCS sessions include: solid propellant rheology; solid propellant surveillance and aging; propellant process engineering; new solid propellant ingredients and formulation development; reduced toxicity liquid propellants; characterization of hypergolic propellants; and solid propellant chemical analysis methods. Topics covered in S&EPS sessions include: space launch range safety; liquid propellant hazards; vapor detection methods for toxic propellant vapors and other hazardous gases; toxicity of propellants, ingredients, and propellant combustion products; personal protective equipment for toxic liquid propellants; and demilitarization/treatment of energetic material wastes.

  18. JANNAF 28th Propellant Development and Characterization Subcommittee and 17th Safety and Environmental Protection Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Cocchiaro, James E. (Editor); Mulder, Edwin J. (Editor); Gomez-Knight, Sylvia J. (Editor)

    1999-01-01

    This volume contains 37 unclassified/unlimited-distribution technical papers that were presented at the JANNAF 28th Propellant Development & Characterization Subcommittee (PDCS) and 17th Safety & Environmental Protection Subcommittee (S&EPS) Joint Meeting, held 26-30 April 1999 at the Town & Country Hotel and the Naval Submarine Base, San Diego, California. Volume II contains 29 unclassified/limited-distribution papers that were presented at the 28th PDCS and 17th S&EPS Joint Meeting. Volume III contains a classified paper that was presented at the 28th PDCS Meeting on 27 April 1999. Topics covered in PDCS sessions include: solid propellant rheology; solid propellant surveillance and aging; propellant process engineering; new solid propellant ingredients and formulation development; reduced toxicity liquid propellants; characterization of hypergolic propellants; and solid propellant chemical analysis methods. Topics covered in S&EPS sessions include: space launch range safety; liquid propellant hazards; vapor detection methods for toxic propellant vapors and other hazardous gases; toxicity of propellants, ingredients, and propellant combustion products; personal protective equipment for toxic liquid propellants; and demilitarization/treatment of energetic material wastes.

  19. The 17th Annual Intelligent Ground Vehicle Competition: intelligent robots built by intelligent students

    NASA Astrophysics Data System (ADS)

    Theisen, Bernard L.

    2010-01-01

    The Intelligent Ground Vehicle Competition (IGVC) is one of four unmanned systems student competitions that were founded by the Association for Unmanned Vehicle Systems International (AUVSI). The IGVC is a multidisciplinary exercise in product realization that challenges college engineering student teams to integrate advanced control theory, machine vision, vehicular electronics and mobile platform fundamentals to design and build an unmanned ground vehicle. Teams from around the world focus on developing a suite of dual-use technologies to equip their system of the future with intelligent driving capabilities. Over the past 17 years, the competition has challenged undergraduate, graduate and Ph.D. students with real world applications in intelligent transportation systems, the military and manufacturing automation. To date, teams from over 70 universities and colleges have participated. This paper describes some of the applications of the technologies required by this competition and discusses the educational benefits. The primary goal of the IGVC is to advance engineering education in intelligent vehicles and related technologies. The employment and professional networking opportunities created for students and industrial sponsors through a series of technical events over the four-day competition are highlighted. Finally, an assessment of the competition based on participation is presented.

  20. PREFACE: 9th World Congress on Computational Mechanics and 4th Asian Pacific Congress on Computational Mechanics

    NASA Astrophysics Data System (ADS)

    Khalili, N.; Valliappan, S.; Li, Q.; Russell, A.

    2010-07-01

    The use for mathematical models of natural phenomena has underpinned science and engineering for centuries, but until the advent of modern computers and computational methods, the full utility of most of these models remained outside the reach of the engineering communities. Since World War II, advances in computational methods have transformed the way engineering and science is undertaken throughout the world. Today, theories of mechanics of solids and fluids, electromagnetism, heat transfer, plasma physics, and other scientific disciplines are implemented through computational methods in engineering analysis, design, manufacturing, and in studying broad classes of physical phenomena. The discipline concerned with the application of computational methods is now a key area of research, education, and application throughout the world. In the early 1980's, the International Association for Computational Mechanics (IACM) was founded to promote activities related to computational mechanics and has made impressive progress. The most important scientific event of IACM is the World Congress on Computational Mechanics. The first was held in Austin (USA) in 1986 and then in Stuttgart (Germany) in 1990, Chiba (Japan) in 1994, Buenos Aires (Argentina) in 1998, Vienna (Austria) in 2002, Beijing (China) in 2004, Los Angeles (USA) in 2006 and Venice, Italy; in 2008. The 9th World Congress on Computational Mechanics is held in conjunction with the 4th Asian Pacific Congress on Computational Mechanics under the auspices of Australian Association for Computational Mechanics (AACM), Asian Pacific Association for Computational Mechanics (APACM) and International Association for Computational Mechanics (IACM). The 1st Asian Pacific Congress was in Sydney (Australia) in 2001, then in Beijing (China) in 2004 and Kyoto (Japan) in 2007. The WCCM/APCOM 2010 publications consist of a printed book of abstracts given to delegates, along with 247 full length peer reviewed papers published with

  1. Genome-wide ancestry of 17th-century enslaved Africans from the Caribbean

    PubMed Central

    Schroeder, Hannes; Ávila-Arcos, María C.; Malaspinas, Anna-Sapfo; Sandoval-Velasco, Marcela; Carpenter, Meredith L.; Moreno-Mayar, José Víctor; Sikora, Martin; Johnson, Philip L. F.; Allentoft, Morten Erik; Samaniego, José Alfredo; Haviser, Jay B.; Dee, Michael W.; Stafford, Thomas W.; Salas, Antonio; Orlando, Ludovic; Willerslev, Eske; Bustamante, Carlos D.; Gilbert, M. Thomas P.

    2015-01-01

    Between 1500 and 1850, more than 12 million enslaved Africans were transported to the New World. The vast majority were shipped from West and West-Central Africa, but their precise origins are largely unknown. We used genome-wide ancient DNA analyses to investigate the genetic origins of three enslaved Africans whose remains were recovered on the Caribbean island of Saint Martin. We trace their origins to distinct subcontinental source populations within Africa, including Bantu-speaking groups from northern Cameroon and non-Bantu speakers living in present-day Nigeria and Ghana. To our knowledge, these findings provide the first direct evidence for the ethnic origins of enslaved Africans, at a time for which historical records are scarce, and demonstrate that genomic data provide another type of record that can shed new light on long-standing historical questions. PMID:25755263

  2. Genome-wide ancestry of 17th-century enslaved Africans from the Caribbean.

    PubMed

    Schroeder, Hannes; Ávila-Arcos, María C; Malaspinas, Anna-Sapfo; Poznik, G David; Sandoval-Velasco, Marcela; Carpenter, Meredith L; Moreno-Mayar, José Víctor; Sikora, Martin; Johnson, Philip L F; Allentoft, Morten Erik; Samaniego, José Alfredo; Haviser, Jay B; Dee, Michael W; Stafford, Thomas W; Salas, Antonio; Orlando, Ludovic; Willerslev, Eske; Bustamante, Carlos D; Gilbert, M Thomas P

    2015-03-24

    Between 1500 and 1850, more than 12 million enslaved Africans were transported to the New World. The vast majority were shipped from West and West-Central Africa, but their precise origins are largely unknown. We used genome-wide ancient DNA analyses to investigate the genetic origins of three enslaved Africans whose remains were recovered on the Caribbean island of Saint Martin. We trace their origins to distinct subcontinental source populations within Africa, including Bantu-speaking groups from northern Cameroon and non-Bantu speakers living in present-day Nigeria and Ghana. To our knowledge, these findings provide the first direct evidence for the ethnic origins of enslaved Africans, at a time for which historical records are scarce, and demonstrate that genomic data provide another type of record that can shed new light on long-standing historical questions.

  3. Learning with Artificial Worlds: Computer-Based Modelling in the Curriculum.

    ERIC Educational Resources Information Center

    Mellar, Harvey, Ed.; And Others

    With the advent of the British National Curriculum, computer-based modeling has become an integral part of the school curriculum. This book is about modeling in education and providing children with computer tools to create and explore representations of the world. Members of the London Mental Models Group contributed their research: (1)…

  4. Learning with Artificial Worlds: Computer-Based Modelling in the Curriculum.

    ERIC Educational Resources Information Center

    Mellar, Harvey, Ed.; And Others

    With the advent of the British National Curriculum, computer-based modeling has become an integral part of the school curriculum. This book is about modeling in education and providing children with computer tools to create and explore representations of the world. Members of the London Mental Models Group contributed their research: (1)…

  5. Real-World Experimentation Comparing Time-Sharing and Batch Processing in Teaching Computer Science,

    DTIC Science & Technology

    effectiveness of time-sharing and batch processing in teaching computer science . The experimental design was centered on direct, ’real world’ comparison...ALGOL). The experimental sample involved all introductory computer science courses with a total population of 415 cadets. The results generally

  6. ICAS, Congress, 17th, Stockholm, Sweden, Sept. 9-14, 1990, Proceedings. Vols. 1 2

    SciTech Connect

    Not Available

    1990-01-01

    The present conference discusses issues in the fields of aeroelasticity, multidisciplinary design integration, slipstreams and jet interference, the aeroacoustics of advanced propellers, simulation technologies for human factors, boundary-layer testing, aircraft sensors and subsystems, high-alpha and vortex flows, rotorcraft design, novel test facilities, high-alpha flow over wings, buckling and postbuckling structural behavior, inlet and nozzle design, simulation and flighttesting, aeroelastic response, systems architecture and integration, unsteady aerodynamics, fatigue and fracture mechanics, and propulsion-system integration. Also discussed are CFD configurations, trajectory optimization and guidance, high-alpha dynamics, combustion phenomena, experimental techniques, structural dynamics and impact effects, computational aids for transport aircraft, drag reduction methods, high-temperature materials, aircraft control methods, impact and crash resistance, transport aircraft design integration, subsonic wings, hypersonic propulsion, structural testing, ATC, high-temperature structures, airworthiness and reliability, military aircraft, composite materials fabrication, nonlinear flight dynamics, and mathematical modeling.

  7. Multivariate geographic clustering on the world`s first zero price/performance parallel computer

    SciTech Connect

    Hoffman, F.M.; Hargrove, W.W.; Schultz, A.J.

    1998-10-01

    The authors present an application of multivariate non-hierarchical statistical clustering to geographic environmental data from the 48 conterminous US in order to produce maps of regions of ecological similarity, called ecoregions. These maps represent more realistic and finer scale regionalizations than those generated by the traditional technique: an expert with a marker pen. Nine input variables thought to affect the growth of vegetation are clustered at a resolution of one square kilometer. These data represent over 7.7 million map cells in a 9-dimensional data space. Denied the funding for the construction of a Beowulf-style cluster of new PCs on which to perform this analysis, the authors built a 126-node cluster out of surplus PCs--primarily Intel 486 CPUs with a host of different motherboards and connected via 10 Mb/s ethernet--obtained at no cost from federal facilities in Oak Ridge, Tennessee. The authors describe the construction of this unique and heterogeneous cluster. Running RedHat Linux with the GNU compiles and both PVM and MPI, this cluster, aptly named the Stone SouperComputer, is the first parallel computer with a price/performance ratio of zero. After developing a serial version of the iterative statistical clustering algorithm, the authors developed a parallel version of the algorithm which uses the MPI message passing routines. The parallel algorithm uses a classical master/slave organization, performs dynamic load balancing for reasonable performance on heterogeneous clusters, and saves intermediate results for easy restarting in case of hardware failure. In addition to being run on the Stone SouperComputer, the parallel algorithm was tested on other parallel platforms without code modification. Finally, the results of the geographic clustering are presented.

  8. Modeling behavior dynamics using computational psychometrics within virtual worlds

    PubMed Central

    Cipresso, Pietro

    2015-01-01

    In case of fire in a building, how will people behave in the crowd? The behavior of each individual affects the behavior of others and, conversely, each one behaves considering the crowd as a whole and the individual others. In this article, I propose a three-step method to explore a brand new way to study behavior dynamics. The first step relies on the creation of specific situations with standard techniques (such as mental imagery, text, video, and audio) and an advanced technique [Virtual Reality (VR)] to manipulate experimental settings. The second step concerns the measurement of behavior in one, two, or many individuals focusing on parameters extractions to provide information about the behavior dynamics. Finally, the third step, which uses the parameters collected and measured in the previous two steps in order to simulate possible scenarios to forecast through computational models, understand, and explain behavior dynamics at the social level. An experimental study was also included to demonstrate the three-step method and a possible scenario. PMID:26594193

  9. Modeling behavior dynamics using computational psychometrics within virtual worlds.

    PubMed

    Cipresso, Pietro

    2015-01-01

    In case of fire in a building, how will people behave in the crowd? The behavior of each individual affects the behavior of others and, conversely, each one behaves considering the crowd as a whole and the individual others. In this article, I propose a three-step method to explore a brand new way to study behavior dynamics. The first step relies on the creation of specific situations with standard techniques (such as mental imagery, text, video, and audio) and an advanced technique [Virtual Reality (VR)] to manipulate experimental settings. The second step concerns the measurement of behavior in one, two, or many individuals focusing on parameters extractions to provide information about the behavior dynamics. Finally, the third step, which uses the parameters collected and measured in the previous two steps in order to simulate possible scenarios to forecast through computational models, understand, and explain behavior dynamics at the social level. An experimental study was also included to demonstrate the three-step method and a possible scenario.

  10. Finding ancient parasite larvae in a sample from a male living in late 17th century Korea.

    PubMed

    Shin, D H; Chai, J Y; Park, E A; Lee, W; Lee, H; Lee, J S; Choi, Y M; Koh, B J; Park, J B; Oh, C S; Bok, G D; Kim, W L; Lee, E; Lee, E J; Seo, M

    2009-06-01

    Parasitological examination of samples from tombs of the Korean Joseon Dynasty (1392-1910) could be helpful to researchers in understanding parasitic infection prevalence in pre-industrial Korean society. Whereas most of our previous parasitological studies revealed the presence of ancient parasite eggs in coprolites of Korean mummies, a sample from a man living in late 17th century Korea proved to be relatively unique in possessing what appeared to be several species of parasite larvae. The larvae identified included Strongyloides stercoralis and Trichostrongylus spp., along with eggs of Ascaris lumbricoides, Trichuris trichiura, and Paragonimus westermani. Since ancient parasite larvae retain enough morphology to make proper species identification possible, even after long burial times, the examination of parasite larvae within ancient samples will be conducted more carefully in our future work.

  11. Late Holocene history of Chaitén Volcano: new evidence for a 17th century eruption

    USGS Publications Warehouse

    Lara, Luis E.; Moreno, Rodrigo; Amigo, Álvaro; Hoblitt, Richard P.; Pierson, Thomas C.

    2013-01-01

    Prior to May 2008, it was thought that the last eruption of Chaitén Volcano occurred more than 5,000 years ago, a rather long quiescent period for a volcano in such an active arc segment. However, increasingly more Holocene eruptions are being identified. This article presents both geological and historical evidence for late Holocene eruptive activity in the 17th century (AD 1625-1658), which included an explosive rhyolitic eruption that produced pumice ash fallout east of the volcano and caused channel aggradation in the Chaitén River. The extents of tephra fall and channel aggradation were similar to those of May 2008. Fine ash, pumice and obsidian fragments in the pre-2008 deposits are unequivocally derived from Chaitén Volcano. This finding has important implications for hazards assessment in the area and suggests the eruptive frequency and magnitude should be more thoroughly studied.

  12. Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology.

    PubMed

    Alexandroff, A B; Burd, R

    2009-05-01

    The 17th Congress of the European Academy of Dermatology and Venereology took place in Paris on 17-20 September 2008 and brought together nearly 11,000 participants. Various plenary lectures, subspecialty meetings, 'free communications', 'top ten', 'test yourself' and 'junior' sessions, 19 courses and 14 'lunches with the expert', six forums, 27 symposia and 45 workshops were pressed into the 4 days of the meeting. Over 1700 posters were presented and exhibited. The themes of a number of symposiums, workshops and sessions overlapped, offering additional educational opportunities despite a very busy schedule. The meeting was well organized. Aesthetic dermatology comprised a significant part of the meeting. It is impossible to encompass all important presentations and we highlight a few medical pearls presented at the meeting; however, our report is not intended as a substitute for reading the conference proceedings and related references quoted in this article.

  13. Venetian Rule and Control of Plague Epidemics on the Ionian Islands during 17th and 18th Centuries

    PubMed Central

    Konstantinidou, Katerina; Mantadakis, Elpis; Sardi, Thalia; Samonis, George

    2009-01-01

    During the 17th and 18th centuries, measures were taken by the Venetian administration to combat plague on the Ionian Islands. At that time, although the scientific basis of plague was unknown, the Venetians recognized its infectious nature and successfully decreased its spread by implementing an information network. Additionally, by activating a system of inspection that involved establishing garrisons along the coasts, the Venetians were able to control all local movements in plague-infested areas, which were immediately isolated. In contrast, the neighboring coast of mainland Greece, which was under Ottoman rule, was a plague-endemic area during the same period. We conclude that even in the absence of scientific knowledge, close observation and social and political measures can effectively restrain infectious outbreaks to the point of disappearance. PMID:19116047

  14. Aberrant expression of circulating Th17, Th1 and Tc1 cells in patients with active and inactive ulcerative colitis.

    PubMed

    Dong, Zhaogang; Du, Lutao; Xu, Xiaofei; Yang, Yongmei; Wang, Haiyan; Qu, Ailin; Qu, Xun; Wang, Chuanxin

    2013-04-01

    Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, yet its etiology and pathogenesis remain poorly understood. The aberrant expression of T lymphocytes plays an essential role in the progression of UC. This study aimed to evaluate the expression profile of circulating Th17, Th1 and Tc1 cells in patients with active and inactive UC. Our results revealed that the percentage of circulating Th17 cells (CD3+CD8-IL-17+) was significantly increased in patients with active UC when compared with the percentage in patients with inactive UC, Crohn's disease (CD) and healthy controls. The percentages of circulating Th1 (CD3+CD8-IFN-γ+) and Tc1 (CD3+CD8+IFN-γ+) cells were also higher in patients with active UC when compared with the percentages in patients with inactive UC and normal controls, although levels were lower than that in CD. Further analysis showed that Th17 cells were positively correlated with Th1 cells, but not with Tc1 cells. Notably, the three cells had a positive correlation with disease activity, extent of disease, detection of erythrocyte sedimentation rate and c-reactive protein in active UC. Moreover, plasma IL-17 was higher in patients with active UC, and a similar trend applied to the mRNA levels of RORγt and T-bet in peripheral blood mononuclear cells (PBMCs). The levels of p-STAT3 and p-STAT5 in PBMCs, as well as the ratio of p-STAT3/p-STAT5, were also elevated in active UC patients. Taken together, our findings revealed that elevated circulating Th17, Th1 and Tc1 cells and the aberrant activation of the STAT pathway may be implicated in the progression of UC. These findings may provide preliminary experimental clues for the development of new therapies for UC.

  15. EDITORIAL: 17th International Summer School on Vacuum, Electron, and Ion Technologies (VEIT 2011)

    NASA Astrophysics Data System (ADS)

    van de Sanden, M. C. M.; Dimitrova, Miglena; Ghelev, Chavdar

    2012-03-01

    The International Summer School on Vacuum, Electron and Ion Technologies (VEIT) has been organized biennially since 1977, when the VEIT Summer School series was launched by the Institute of Electronics, Bulgarian Academy of Sciences. The aim was to act as a forum for the exchange and dissemination of knowledge and ideas on the latest developments in electron-, ion- and plasma-assisted technologies. The organizers of the 2011 edition of the event were the Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria and the Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands. Whilst the school initially provided a meeting place for researchers mainly from Eastern and Central European countries, its importance has grown issue by issue. The school is now a major scientific event and a meeting place for young scientists from Eastern and Western Europe involved in research and development associated with high-tech industries. Many former school participants have gone on to become leading scientists in research establishments and companies throughout the world. Leading international companies, such as High Voltage Engineering, Balzers, Varian, and Hauzer have used the VEIT forum to present their products through oral presentations, poster contributions and exhibits. The School Proceedings have been published in special issues of the international journals Vacuum, Plasma Processes and Polymers and Journal of Physics: Conference Series. The Seventeenth edition of VEIT was held in the Black Sea resort of Sunny Beach, Bulgaria on 19-23 September 2011. It was attended by 96 participants from 18 countries: Belgium, Brazil, Bulgaria, Czech Republic, Denmark, France, Germany, Greece, The Netherlands, Romania, Russia, Serbia, Sweden, Switzerland, Turkey, Ukraine, UK and USA. Following the tradition of publishing the VEIT Proceedings, a selection of papers presented at the event is published in this special issue of Journal of

  16. Insights from the 3rd World Congress on Integrated Computational Materials Engineering

    NASA Astrophysics Data System (ADS)

    Howe, D.; Goodlet, B.; Weaver, J.; Spanos, G.

    2016-05-01

    The 3rd World Congress on Integrated Computational Materials Engineering (ICME) was a forum for presenting the "state-of-the-art" in the ICME discipline, as well as for charting a path for future community efforts. The event concluded with in an interactive panel-led discussion that addressed such topics as integrating efforts between experimental and computational scientists, uncertainty quantification, and identifying the greatest challenges for future workforce preparation. This article is a summary of this discussion and the thoughts presented.

  17. Decreased percentages of regulatory T cells are necessary to activate Th1-Th17-Th22 responses during acute rejection of the peripheral nerve xenotransplantation in mice.

    PubMed

    Chai, Huihui; Yang, Lujun; Gao, Lei; Guo, Yanwu; Li, Hui; Fan, Xulong; Wu, Bolin; Xue, Shan; Cai, Yingqian; Jiang, Xiaodan; Qin, Bing; Zhang, Shizhong; Ke, Yiquan

    2014-10-15

    T cells have major functions in the initiation and perpetuation of nerve graft rejection. Our study aimed to investigate the function of regulatory T cells (Treg)-Th1-Th17-Th22 cells in the rejection of peripheral nerve xenotransplantation. Adult male C57 BL/6 mice were used as the recipient for nerve xenotransplantation, and Sprague-Dawley rats were used as the donor. These nerve xenotransplanted mice were used as the experimental groups, and those that received autograft transplant were chosen as the control group. All of the animals were pretreated with interferon (IFN)-γ, interleukin (IL)-17, and IL-22 before the experiment was conducted. The percentages of spleen Treg-Th1-Th17-Th22 cells were evaluated by flow cytometry 1, 3, 7, 14, and 28 days after transplantation. Serum levels of IFN-γ, IL-17, and IL-22 were assessed by enzyme-linked immunosorbent assay. Statistical analysis was performed by Wilcoxon rank sum and Spearman correlation test. During acute rejection, the percentages of Th1-Th17-Th22 cells in the spleen and serum IFN-γ, IL-17, and IL-22 levels in the experimental group increased compared with those in the control group. By contrast, CD4CD25Foxp3 T cell level decreased. The rejection of xenograft was significantly prevented after the mice were treated with IL-17-neutralizing, IL-22-neutralizing, and IFN-γ-neutralizing antibodies. Moreover, the percentage of CD4CD25Foxp3 Treg was negatively correlated with the percentages of Th1-Th17-Th22 cells and levels of IL-17, IL-22, and IFN-γ. These results suggested that the Treg-Th1-Th17-Th22 cells involved in xenotransplant rejection and imbalance between Tregs and Th1-Th17-Th22 cells contribute to the acute rejection of peripheral nerve xenotransplant.

  18. An Apprenticeship-Based Multimedia Courseware for Computer Graphics Studies Provided on the World Wide Web.

    ERIC Educational Resources Information Center

    Shabo, Amnon; Guzdial, Mark; Stasko, John

    1997-01-01

    Discusses cognitive apprenticeship, an educational practice that focuses on students actively engaged in activities with a variety of supports, or scaffolding. Presents a model of scaffolding that was implemented in courseware for learning computer graphics on the World Wide Web. An evaluation on the use of the courseware at Georgia Institute of…

  19. Design Principles for "Thriving in Our Digital World": A High School Computer Science Course

    ERIC Educational Resources Information Center

    Veletsianos, George; Beth, Bradley; Lin, Calvin; Russell, Gregory

    2016-01-01

    "Thriving in Our Digital World" is a technology-enhanced dual enrollment course introducing high school students to computer science through project- and problem-based learning. This article describes the evolution of the course and five lessons learned during the design, development, implementation, and iteration of the course from its…

  20. Design Principles for "Thriving in Our Digital World": A High School Computer Science Course

    ERIC Educational Resources Information Center

    Veletsianos, George; Beth, Bradley; Lin, Calvin; Russell, Gregory

    2016-01-01

    "Thriving in Our Digital World" is a technology-enhanced dual enrollment course introducing high school students to computer science through project- and problem-based learning. This article describes the evolution of the course and five lessons learned during the design, development, implementation, and iteration of the course from its…

  1. Tritium Packages and 17th RH Canister Categories of Transuranic Waste Stored Below Ground within Area G

    SciTech Connect

    Hargis, Kenneth Marshall

    2015-03-01

    A large wildfire called the Las Conchas Fire burned large areas near Los Alamos National Laboratory (LANL) in 2011 and heightened public concern and news media attention over transuranic (TRU) waste stored at LANL’s Technical Area 54 (TA-54) Area G waste management facility. The removal of TRU waste from Area G had been placed at a lower priority in budget decisions for environmental cleanup at LANL because TRU waste removal is not included in the March 2005 Compliance Order on Consent (Reference 1) that is the primary regulatory driver for environmental cleanup at LANL. The Consent Order is a settlement agreement between LANL and the New Mexico Environment Department (NMED) that contains specific requirements and schedules for cleaning up historical contamination at the LANL site. After the Las Conchas Fire, discussions were held by the U.S. Department of Energy (DOE) with the NMED on accelerating TRU waste removal from LANL and disposing it at the Waste Isolation Pilot Plant (WIPP). This report summarizes available information on the origin, configuration, and composition of the waste containers within the Tritium Packages and 17th RH Canister categories; their physical and radiological characteristics; the results of the radioassays; and potential issues in retrieval and processing of the waste containers.

  2. Comparison between electromagnetic induction and fluxgate gradiometer measurements on the buried remains of a 17th century castle

    NASA Astrophysics Data System (ADS)

    Simpson, David; Lehouck, Alexander; Verdonck, Lieven; Vermeersch, Hans; Van Meirvenne, Marc; Bourgeois, Jean; Thoen, Erik; Docter, Roald

    2009-06-01

    This study aimed to evaluate the different configurations of an electromagnetic induction (EMI) sensor, the EM38DD (Geonics Limited, Canada) with fluxgate gradiometer measurements on an archaeological site. The EM38DD allows measuring both the apparent magnetic susceptibility (MSa or χa) and the apparent electrical conductivity (ECa or σa) in two different coil orientations. A gradiometer measures the lateral variations of the vertical magnetic field gradient, caused by the induced and remanent magnetisations. An archaeological site where historical documents indicated the presence of a 17th century brick castle was selected as a test area. The results of the first survey with the EM38DD showed very strong magnetic anomalies in the central field, which were caused by the brick remains of the castle. Therefore, a smaller area was chosen within this field to compare the different configurations of the EM38DD with the gradiometer at the same measurement resolution. The most useful results with the EM38DD were obtained from the MSa measured in a vertical coplanar orientation. Its anomalies corresponded well with the gradiometer anomalies. The gradiometer anomalies were sharper defined than the EM38DD anomalies, but were complicated by the bipolar response pattern. The MSa map in horizontal coplanar orientation was very difficult to interpret, due to the less optimal spatial sensitivity. The wall remains were not visible in the ECa map in horizontal coplanar orientation, although other interesting anomalies were detected.

  3. [Principles of order in the color systems of the 17th century. (Franciscus Aguilonius--Athanasius Kircher--Isaac Newton)].

    PubMed

    Jaeger, W

    1984-04-01

    Since Aristotle there have been two colour order systems: The first is according to the subjective luminosity of colours, and the second is that which is found in the rainbow. Almost all the medieval concepts of colour order were based on the subjective luminosity of colours. At the beginning of the 17th century Franciscus Aguilonius still described the traditional sequence according to subjective luminosity: white, yellow, red, blue and black in his colour order system. - Athanasius Kircher demonstrated two sequences: The first was the same as Aguilonius 's, completed by lists of symbolic qualities attributed to the respective colours; The second was the sequence of the prismatic spectrum; red, orange, yellow, green and blue. Violet was still missing from his spectrum. For that reason the idea of arranging the colours in a closed circle did not occur to him. - Isaac Newton added violet to the prismatic spectrum. Hence he was able to bring the ends of the spectrum together, forming a colour circle. He completed the colours of his spectrum "with those purple hues which, although not present in the spectrum, were familiar to painters and dyers , and in this way closed up the colour-circle into a band returning on itself" (W. Ostwald). Thus he combined the perceptual concept of the colour wheel, containing pairs of complementary colours, with the physical concept of the prismatic spectrum.

  4. Microscopy and Microanalysis of an Extreme Case of Salt and Biodegradation in 17th Century Wall Paintings.

    PubMed

    Gil, Milene; Martins, Maria Rosário; Carvalho, Maria Luisa; Souto, Cátia; Longelin, Stephane; Cardoso, Ana; Mirão, José; Candeias, António Estevão

    2015-06-01

    The present study characterizes the main deterioration mechanisms affecting the early 17th frescoes of Casa de Fresco, the only known example in Portugal of a semi-underground leisure room richly decorated with a balcony over a water well. Frescoes from the vault are at risk due to salt weathering and biodeterioration. The aim of the research was identification of the deterioration materials, determination of their origin, and their effect on the frescoes before future intervention. Scanning electron microscopy with an energy-dispersive X-ray detector (SEM-EDS) was used to determine salt morphology and microanalysis. The mineralogical characterization was performed by X-ray powder diffraction, complemented with µ-Raman and µ-Fourier transform infrared spectroscopy. Biological assessment was evaluated with optical microscopy and SEM-EDS. Bacterial and fungal isolation and identification were performed using standard culture media and methods according to Bergey's Manual of Systematic Bacteriology and from the Compendium of Soil Fungi. The results show that Ca and Ca-Mg carbonates from the paint renderings are the predominant salt species affecting the site. Bacterial strains from the genera Bacillus and Pseudomonas and fungal strains from the Cladosporium spp. and Penicillium spp. were isolated in the salt formations, within and between the mortar layers. Azurite, malachite, and smalt paint layers are the most affected by the weathering conditions.

  5. Acute Abdomen in the 17th Week of Twin Pregnancy due to Ovarian Torsion – A Late Complication of IVF

    PubMed Central

    Habek, D.; Bauman, R.; Rukavina Kralj, L.; Hafner, T.; Turudic, T.; Vujisic, S.

    2016-01-01

    Background: A 32-year-old woman with tubal factor infertility due to bilateral laparoscopic salpingectomy conceived twins with in vitro fertilization (IVF). She developed moderate ovarian hyperstimulation syndrome which was treated with anticoagulant therapy. The subsequent course of the twin pregnancy was normal until the 17th week of gestation when she presented to hospital because of a sharp pain in the right lower abdomen which ceased after admission. Case: Except for a single incident of vomiting, patient had no other subjective symptoms. The clinical examination showed tenderness of the lower right abdominal segment on palpation. The surgeon and the urologist found no signs of an acute surgical or urologic condition, and laboratory findings were within normal reference ranges for pregnant women. Two days after admission the pain reappeared; it was now much stronger and colic-like. The pain was initially located supraumbilically but subsequently spread diffusely across the lower abdomen. Abdominal guarding was present and laboratory findings showed an increase in inflammatory parameters. An enlarged and edematous right ovary was found on transvaginal ultrasound. Conclusion: Exploratory laparotomy via a vertical midline abdominal transection revealed a torqued necrotic right ovary with elements of inflammation and inflammatory adhesions involving the entire pelvis. The patient underwent right-sided ovariectomy and adhesiolysis. Recovered was normal and the patient was delivered of healthy twins in the 37th week of gestation. PMID:28017976

  6. Aspects of informed consent in medical practice in the eastern Mediterranean region during the 17th and 18th centuries.

    PubMed

    Christopoulos, Platon; Falagas, Matthew E; Gourzis, Philippos; Trompoukis, Constantinos

    2007-08-01

    Informed consent is a question of central importance in contemporary medical ethics, and clinical practice is inconceivable without considering the issues it raises. Although it is often vigorously argued that consent, informed or otherwise, is a recent phenomenon and that no sources testify to its existence before the 20th century, it is difficult to accept that a process for regulating the common and fundamental parameters in the relationship between doctor and patient and the planning of treatment had not concerned previous eras. A review of the Registers of the Islamic Court of Candia (Heraklion) in Crete, a series of records that touches on, among other things, matters of medical interest, reveals that the concept of informed consent was not only known during a period that stretched from the mid-17th to the early 19th century, but it was concerned with the same principles that prevail or have been a point of contention today. An extension of this study into other periods may thus provide contemporary researchers with material and information valuable in the discussion of today's bioethical issues.

  7. The Sommersdorf mummies—An interdisciplinary investigation on human remains from a 17th-19th century aristocratic crypt in southern Germany

    PubMed Central

    Kellinghaus, Manuel; Jackowski, Christian; Shved, Natallia; Rühli, Frank; Maixner, Frank; Zink, Albert; Rosendahl, Wilfried; Lösch, Sandra

    2017-01-01

    Sommersdorf Castle (Bavaria, Germany) is a medieval castle complex which has been inhabited by the aristocratic family von Crailsheim. The deceased were entombed in a crypt located in the parapets underneath the castle’s church, resulting in mummification of the bodies. Based on the family chronicle and oral history, identities have been ascribed to the mummies. The aim of the study is therefore to test the accuracy of the historical records in comparison to archaeological, anthropological and genetic data. Today, the crypt houses eleven wooden coffins from the 17th to 19th century AD. In ten of these, mummified and scattered human remains were found. Archive records were studied in order to identify names, ancestry, titles, occupation, date of birth and death, and place of interment of the individuals. The coffins were visually inspected and dated by typo-chronology, and the mummified and scattered skeletal remains were subjected to a physical anthropological examination. In total, the crypt contains the remains of a minimum number of nine individuals, among them three adult males, five adult females and one infant. A detailed scientific examination, including prior conservation, ancient DNA analyses, and computed tomography (CT), was performed on five mummies. By means of the CT data age at death, sex, body height, pathologies, and anatomical variants were investigated. CT analysis further showed that the bodies were naturally mummified. Mitochondrial DNA analyses revealed that the tested individuals are not maternally related. In addition, health, living conditions and circumstances of death of the entombed individuals could be highlighted. Being confronted with the strengths, weaknesses and limitations of each methodological approach, probable identification was achieved in two cases. PMID:28859116

  8. The Sommersdorf mummies-An interdisciplinary investigation on human remains from a 17th-19th century aristocratic crypt in southern Germany.

    PubMed

    Alterauge, Amelie; Kellinghaus, Manuel; Jackowski, Christian; Shved, Natallia; Rühli, Frank; Maixner, Frank; Zink, Albert; Rosendahl, Wilfried; Lösch, Sandra

    2017-01-01

    Sommersdorf Castle (Bavaria, Germany) is a medieval castle complex which has been inhabited by the aristocratic family von Crailsheim. The deceased were entombed in a crypt located in the parapets underneath the castle's church, resulting in mummification of the bodies. Based on the family chronicle and oral history, identities have been ascribed to the mummies. The aim of the study is therefore to test the accuracy of the historical records in comparison to archaeological, anthropological and genetic data. Today, the crypt houses eleven wooden coffins from the 17th to 19th century AD. In ten of these, mummified and scattered human remains were found. Archive records were studied in order to identify names, ancestry, titles, occupation, date of birth and death, and place of interment of the individuals. The coffins were visually inspected and dated by typo-chronology, and the mummified and scattered skeletal remains were subjected to a physical anthropological examination. In total, the crypt contains the remains of a minimum number of nine individuals, among them three adult males, five adult females and one infant. A detailed scientific examination, including prior conservation, ancient DNA analyses, and computed tomography (CT), was performed on five mummies. By means of the CT data age at death, sex, body height, pathologies, and anatomical variants were investigated. CT analysis further showed that the bodies were naturally mummified. Mitochondrial DNA analyses revealed that the tested individuals are not maternally related. In addition, health, living conditions and circumstances of death of the entombed individuals could be highlighted. Being confronted with the strengths, weaknesses and limitations of each methodological approach, probable identification was achieved in two cases.

  9. Computer and World Wide Web accessibility by visually disabled patients: problems and solutions.

    PubMed

    Chiang, Michael F; Cole, Roy G; Gupta, Suhit; Kaiser, Gail E; Starren, Justin B

    2005-01-01

    Rapid advances in information technology have dramatically transformed the world during the past several decades. Access to computers and the World Wide Web is increasingly required for education and employment, as well as for many activities of daily living. Although these changes have improved society in many respects, they present an obstacle for visually disabled patients who may have significant difficulty processing the visual cues presented by modern graphical user interfaces. This article reviews the specific barriers to computer and Web access faced by visually disabled patients, describes clinical evaluation methods, summarizes traditional low vision methods as well as newer assistive computer technologies for universal accessibility, and discusses emerging technologies and future directions in this area.

  10. Virtual plagues and real-world pandemics: reflecting on the potential for online computer role-playing games to inform real world epidemic research.

    PubMed

    Oultram, Stuart

    2013-12-01

    In the wake of the Corrupted Blood incident, which afflicted the massively multiplayer online computer role-playing game World of Warcraft in 2005, it has been suggested that both, the incident itself and massively multiplayer online computer role-playing games in general, can be utilised to inform and assist real-world epidemic and public health research. In this paper, I engage critically with these claims.

  11. Tick-borne encephalitis as a notifiable disease--Status quo and the way forward. Report of the 17th annual meeting of the International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE).

    PubMed

    Kunze, Ursula

    2015-07-01

    The 17th meeting of the International Scientific Working Group on Tick-Borne Encephalitis (ISW-TBE), a group of neurologists, general practicioners, clinicians, travel physicians, virologists, pediatricians, and epidemiologists, was held under the title "Tick-borne encephalitis as a notifiable disease--status quo and the way forward". The conference agenda was divided into three parts on the first day: "Epidemiology & Risk areas", "Poster Walk: Epidemiological Update in Europe", and "News in TBE Research". On the second day, a World Café Working Session took place where the participants could choose three tables out of six to join for discussion. Key topics on current epidemiological developments and investigations, risk areas, cases, travel and mobility, TBE in children, vaccination rates, and latest news on vaccination were presented and extensively discussed.

  12. Reports: Programme Commissions, Administrative Commission, Legal Committee. Records of the General Conference (17th, Paris, 17 October to 21 November 1972), Volume 2.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    The reports of the Programme Commissions, the Administrative Commission, and Legal Committee are presented as the records of the 17th session of the General Conference of UNESCO in 1972. Part 1 contains Programme Commissions reports on education; natural sciences and their application to development; social sciences, humanities, and culture;…

  13. Teaching Science in Art: Technical Examination of 17th-Century Dutch Painting as Interdisciplinary Coursework for Science Majors and Nonmajors

    ERIC Educational Resources Information Center

    Uffelman, Erich S.

    2007-01-01

    Two linked courses examining conservation science and art history of 17th-century Dutch painting are described. The two courses have been taught on campus and, most recently, as study-abroad courses in collaboration with the Center for European Studies, Universiteit Maastricht, The Netherlands. The highly interdisciplinary courses are intense, yet…

  14. Providing Quality Education and Training for Rural Australians. SPERA National Conference Proceedings (17th, Wagga Wagga, New South Wales, Australia, July 8-11, 2001).

    ERIC Educational Resources Information Center

    Hemmings, Brian, Ed.; Boylan, Colin, Ed.

    This proceedings of the 17th annual conference of the Society for the Provision of Education in Rural Australia (SPERA) contains 28 keynote addresses and conference papers. Major conference themes were vocational education and training (VET) in rural schools, small schools, flexible rural delivery systems, and the community as a resource and…

  15. Teaching Science in Art: Technical Examination of 17th-Century Dutch Painting as Interdisciplinary Coursework for Science Majors and Nonmajors

    ERIC Educational Resources Information Center

    Uffelman, Erich S.

    2007-01-01

    Two linked courses examining conservation science and art history of 17th-century Dutch painting are described. The two courses have been taught on campus and, most recently, as study-abroad courses in collaboration with the Center for European Studies, Universiteit Maastricht, The Netherlands. The highly interdisciplinary courses are intense, yet…

  16. Reports: Programme Commissions, Administrative Commission, Legal Committee. Records of the General Conference (17th, Paris, 17 October to 21 November 1972), Volume 2.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). General Conference.

    The reports of the Programme Commissions, the Administrative Commission, and Legal Committee are presented as the records of the 17th session of the General Conference of UNESCO in 1972. Part 1 contains Programme Commissions reports on education; natural sciences and their application to development; social sciences, humanities, and culture;…

  17. Mechanisms of Mind: Highlights of the 17th Annual Meeting of the American Neuropsychiatric Association, February 18-21, 2006, San Diego, CA.

    PubMed

    Cunningham, Miles G; Sewell, R Andrew; Price, Bruce H

    2006-01-01

    Points of interest from the 17th Annual American Neuropsychiatric Association are reviewed, including several cognitive neuroscience frameworks that have been proposed to account for the neural basis of moral cognition. Also discussed are the brain mechanisms behind creative innovation, and an overview is presented of several of this year's outstanding contributions to clinical and basic neuroscience.

  18. Landscape paintings of the 17th and 19th century as a tool for coastal zone management

    NASA Astrophysics Data System (ADS)

    Jungerius, P. D.; van den Ancker, J.

    2012-04-01

    For more than fifty years many Dutch landscapes suffered severe damage. For their management, it is valuable to know what they looked like in the past. Historic maps give inadequate information, and landscape and aerial photographs are scarcely available until the 1940s. Before then landscapes have been documented chiefly by landscape painters. Interpreted with care, Dutch landscape paintings of the 17th and 19th century are an invaluable geoheritage archive and also hold information that is relevant for present-day landscape management. We present paintings of the Dutch coastal zone as an example. The coastal zone of the Netherlands is geomorphologically well developed, with beaches, foredunes, medieval 'Young dunes', and 5000 year old beach ridges with several anthropic modifications. Each of these terrains attracted landscape painters. Representative paintings can be found in museums and art galleries. We evaluated hundreds of paintings of the collection of Simonis & Buunk, an art gallery in Ede specialised in 19th and early 20th century landscape paintings, for the geoheritage information they contain. The collection, which is the largest on the subject on¬line available in Europe, can be freely consulted (www.simonis--buunk.com). The freedom taken by the painters to adjust reality for compositional or stylistic reasons is still subject of discussion. The paintings became more realistic in the middle of the 19th century when paints became available in tubes and the painters could leave their studio to work in the field. We selected paintings that are sufficiently realistic to be translated in real landscape features, including geomorphological processes and elements. Some insights: • Because of the overriding control of marine and eolian processes, the appearance of the beaches has not changed since the 16th century. • The difference between the flat beaches of the Netherlands and the steeper beaches is accurately registered by the painters. • On a coast

  19. The role of inductive electric fields in the ring current enhancement during the March 17th, 2013 geomagnetic storm

    NASA Astrophysics Data System (ADS)

    Ilie, R.; Toth, G.; Liemohn, M. W.; Chan, A. A.

    2016-12-01

    The terrestrial magnetosphere has the capability to rapidly accelerate charged particles up to very high energies over relatively short times and distances. These energetic particles are injected from the magnetotail into the inner magnetosphere through two primary mechanisms. One transport method is the potential-driven convection during periods of southward IMF, which allows part of the dawn-to-dusk solar wind electric field to effectively map down to the polar ionosphere. The second transport process involves a sudden reconfiguration of the magnetic field and the creation of transient induced electric fields. However, it is not possible to distinguish the two terms by only measuring the electric field. Assessing the relative contribution of potential versus inductive electric fields at the energization of the hot ion population in the inner magnetosphere is only possible by thorough examination of the time varying magnetic field and current systems using global modeling of the entire system. We developed a novel method to calculate the inductive and potential components of electric field in the entire magnetosphere domain. This approach removes the need to trace independent field lines and lifts the assumption that the magnetic field lines can be treated as frozen in a stationary ionosphere. We quantify the relative contributions of potential and inductive electric fields at driving plasma sheet ions into the inner magnetosphere during the March 17th, 2103 geomagnetic storm. The consequence of these injections on the distortion of the near-Earth magnetic field and current systems have been rarely separated in order to determine their relative effectiveness from a global perspective.

  20. Hydrometeorological extremes reconstructed from documentary evidence for the Jihlava region in the 17th-19th centuries

    NASA Astrophysics Data System (ADS)

    Dolak, Lukas; Brazdil, Rudolf; Chroma, Katerina; Valasek, Hubert; Belinova, Monika; Reznickova, Ladislava

    2016-04-01

    Different documentary evidence (taxation records, chronicles, insurance reports etc.) is used for reconstruction of hydrometeorological extremes (HMEs) in the Jihlava region (central part of the recent Czech Republic) in the 17th-19th centuries. The aim of the study is description of the system of tax alleviation in Moravia, presentation of utilization of early fire and hail damage insurance claims and application of the new methodological approaches for the analysis of HMEs impacts. During the period studied more than 400 HMEs were analysed for the 16 estates (past basic economic units). Late frost on 16 May 1662 on the Nove Mesto na Morave estate, which destroyed whole cereals and caused damage in the forests, is the first recorded extreme event. Downpours causing flash floods and hailstorms are the most frequently recorded natural disasters. Moreover, floods, droughts, windstorms, blizzards, late frosts and lightning strikes starting fires caused enormous damage as well. The impacts of HMEs are classified into three categories: impacts on agricultural production, material property and the socio-economic impacts. Natural disasters became the reasons of losses of human lives, property, supplies and farming equipment. HMEs caused damage to fields and meadows, depletion of livestock and triggered the secondary consequences as lack of seeds and finance, high prices, indebtedness, poverty and deterioration in field fertility. The results are discussed with respect to uncertainties associated with documentary evidences and their spatiotemporal distribution. Archival records, preserved in the Moravian Land Archives in Brno and other district archives, create a unique source of data contributing to the better understanding of extreme events and their impacts.

  1. Floods of the Lower Tisza from the late 17th century onwards: frequency, magnitude, seasonality and great flood events

    NASA Astrophysics Data System (ADS)

    Kiss, Andrea

    2016-04-01

    The present paper is based on a recently developed database including contemporary original, administrative, legal and private source materials (published and archival) as well as media reports related to the floods occurred on the lower sections of the Tisza river in Hungary, with special emphasis on the area of Szeged town. The study area is well-represented by contemporary source evidence from the late 17th century onwards, when the town and its broader area was reoccupied from the Ottoman Turkish Empire. Concerning the applied source materials, the main bases of investigation are the administrative (archival) sources such as town council protocols of Szeged and county meeting protocols of Csanád and Csongrád Counties. In these (legal-)administrative documents damaging events (natural/environmental hazards) were systematically recorded. Moreover, other source types such as taxation-related damage accounts as well as private and official reports, letters and correspondence (published, unpublished) were also included. Concerning published evidence, a most important source is flood reports in contemporary newspapers as well as town chronicles and other contemporary narratives. In the presentation the main focus is on the analysis of flood-rich flood-poor periods of the last ca. 330 years; moreover, the seasonality distribution as well as the magnitude of Tisza flood events are also discussed. Another important aim of the poster is to provide a short overview, in the form of case studies, on the greatest flood events (e.g. duration, magnitude, damages, multi-annual consequences), and their further impacts on the urban and countryside development as well as on (changes in) flood defence strategies. In this respect, especially two flood events, the great (1815-)1816 and the catastrophic 1879 flood (shortly with causes and consequences) - that practically erased Szeged town from the ground - are presented in more detail.

  2. The relativistic solar particle event of May 17th, 2012 observed on board the International Space Station

    NASA Astrophysics Data System (ADS)

    Berrilli, Francesco; Casolino, Marco; Del Moro, Dario; Di Fino, Luca; Larosa, Marianna; Narici, Livio; Piazzesi, Roberto; Picozza, Piergiorgio; Scardigli, Stefano; Sparvoli, Roberta; Stangalini, Marco; Zaconte, Veronica

    2014-05-01

    High-energy charged particles represent a severe radiation risk for astronauts and spacecrafts and could damage ground critical infrastructures related to space services. Different natural sources are the origin of these particles, among them galactic cosmic rays, solar energetic particles and particles trapped in radiation belts. Solar particle events (SPE) consist in the emission of high-energy protons, alpha-particles, electrons and heavier particles from solar flares or shocks driven by solar plasma propagating through the corona and interplanetary space. Ground-level enhancements (GLE) are rare solar events in which particles are accelerated to near relativistic energies and affect space and ground-based infrastructures. During the current solar cycle 24 a single GLE event was recorded on May 17th, 2012 associated with an M5.1-class solar flare. The investigation of such a special class of solar events permits us to measure conditions in space critical to both scientific and operational research. This event, classified as GLE71, was detected on board the International Space Station (ISS) by the active particle detectors of the ALTEA (Anomalous Long Term Effects in Astronauts) experiment. The collected data permit us to study the radiation environment inside the ISS. In this work we present the first results of the analysis of data acquired by ALTEA detectors during GLE71 associated with an M5.1-class solar flare. We estimate the energy loss spectrum of the solar particles and evaluate the contribution to the total exposure of ISS astronauts to solar high-energy charged particles.

  3. Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus.

    PubMed

    Piccinni, M-P; Lombardelli, L; Logiodice, F; Tesi, D; Kullolli, O; Biagiotti, R; Giudizi, Mg; Romagnani, S; Maggi, E; Ficarra, G

    2014-03-01

    The role of Th17 cells and associated cytokines was investigated in oral lichen planus. 14 consecutive patients with oral lichen planus were investigated. For biological studies, tissues were taken from reticular or erosive lesions and from normal oral mucosa (controls) of the same patient. mRNA expression for IL-17F, IL-17A, MCP-1, IL-13, IL-2, IL-10, IL-1β, RANTES, IL-4, IL-12B, IL-8, IFN-γ, TNF-α, IL-1α, IL-18, TGF-β1, IL-23R, IL-7, IL-15, IL-6, MIG, IP-10, LTB, VEGF, IL-5, IL-27, IL-23A, GAPDH, PPIB, Foxp3, GATA3, and RORC was measured using the QuantiGene 2.0. Results showed that Th17-type and Th0-type molecules' mRNAs, when compared with results obtained from tissue controls, were increased in biopsies of erosive lesions, whereas Th2-type molecules' mRNAs were increased in reticular lesions. When the CD4+ T-cell clones, derived from oral lichen planus tissues and tissue controls, were analyzed, a higher prevalence of Th17 (confirmed by an increased CD161 expression) and Th0 CD4+ T clones was found in erosive lesions, whereas a prevalence of Th2 clones was observed in reticular lesions. Our data suggest that Th17, Th0, and Th2 cells, respectively, may have a role in the pathogenesis of erosive and reticular oral lichen planus. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. The ``System of Chymists'' and the ``Newtonian dream'' in Greek-speaking Communities in the 17th-18th Centuries

    NASA Astrophysics Data System (ADS)

    Bokaris, Efthymios P.; Koutalis, Vangelis

    2008-06-01

    The acceptance of new chemical ideas, before the Chemical Revolution of Lavoisier, in Greek-speaking communities in the 17th and 18th centuries did not create a discourse of chemical philosophy, as it did in Europe, but rather a “philosophy” of chemistry as it was formed through the evolution of didactic traditions of Chemistry. This “philosophical” chemistry was not based on the existence of any academic institutions, it was focused on the ontology of principles and forces governing the analysis/synthesis of matter and formulated two didactic traditions. The one, named “the system of chymists”, close to the Boylean/Cartesian tradition, accepted, contrary to Aristotelianism, the five “chymical” principles and also the analytical ideal, but the “chymical” principles were not under a conceptual and experimental investigation, as they were in Europe. Also, a crucial issue for this tradition remained the “mechanical” principles which were under the influence of the metaphysical nature of the Aristotelian principles. The other, close to the Boylean/Newtonian tradition, was the integrated presentation of the Newtonian “dream”, which maintained a discursive attitude with reference to the “chemical attractions”-“chemical affinities” and actualised the mathematical atomism of Boscovich, according to which the elementary texture of matter could be causally explained within this complex architecture of mathematical “ punkta”. In this tradition also coexisted, in a discursive synthesis, the “chemical element” of Lavoisier and the arguments of the new theory and its opposition to the phlogiston theory, but the “chemical affinities” were under the realm of the “physical element” as “metaphysical point”.

  5. From image pair to a computer generated hologram for a real-world scene.

    PubMed

    Ding, Sihao; Cao, Siyang; Zheng, Yuan F; Ewing, Robert L

    2016-09-20

    We propose an approach to produce computer generated holograms (CGHs) from image pairs of a real-world scene. The ratio of the three-dimensional (3D) physical size of the object is computed from the image pair to provide the correct depth cue. A multilayer wavefront recording plane method completed with a two-stage occlusion culling process is carried out for wave propagation. Multiple holograms can be generated by propagating the wave toward the desired angles, to cover the circular views that are wider than the viewing angle restricted by the wavelength and pitch size of a single hologram. The impact of the imperfect depth information extracted from the image pair on CGH is examined. The approach is evaluated extensively on image pairs of real-world 3D scenes, and the results demonstrate that the circular-view CGH can be produced from a pair of stereo images using the proposed approach.

  6. Scientific computation of big data in real-world clinical research.

    PubMed

    Li, Guozheng; Zuo, Xuewen; Liu, Baoyan

    2014-09-01

    The advent of the big data era creates both opportunities and challenges for traditional Chinese medicine (TCM). This study describes the origin, concept, connotation, and value of studies regarding the scientific computation of TCM. It also discusses the integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinical scientific research. TCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensation levels; however, primary methods are used to convert them into statistics, such as the methods of feature subset optimizing, multi-label learning, and complex networks based on complexity, intelligence, data, and computing sciences. Furthermore, these methods are applied in the modeling and analysis of the various complex relationships in individualized clinical diagnosis and treatment, as well as in decision-making related to such diagnosis and treatment. Thus, these methods strongly support the real-world clinical research paradigm of TCM.

  7. The historical archaeology of the 17th- and 18th-century Jewish community of Nevis, British West Indies

    NASA Astrophysics Data System (ADS)

    Terrell, Michelle M.

    2000-11-01

    This is an historical archaeological examination of a 17th- and 18th-century Jewish community on the island of Nevis in the British West Indies. Unlike earlier archaeological studies of the Jewish Caribbean Diaspora that focused on single sites, this investigation used a community-wide approach to elucidate the daily experience of Sephardic Jews within the colonial Caribbean. This project included an archaeological excavation at the purported location of the community's synagogue, an electrical resistivity survey of the surviving cemetery, the construction of a map of property ownership in 18th-century Charlestown, and archival research. This study was carded out within a multiscalar and contextual framework that emphasized the importance of understanding the diaspora that brought the Jews to the West Indies, the development of the colonial Caribbean, and the surrounding environs of the port city of Charlestown, Nevis. The archaeological analysis of the supposed site of the synagogue proved that it was in fact that of a late 18th-century townhouse, but the associated land record research revealed the actual location of the community's former synagogue. Furthermore, the reconstruction of the physical layout of colonial-period Charlestown from the land records indicated the presence of a distinct Jewish quarter in the undesirable southern portion of the town. Evidence from the public records of Nevis and the social history of the members of the Jewish population unveiled external social and political pressures placed upon the Sephardim as well as internal religious and ethnic ties dig bound the community together. It is argued in closing that the archival evidence, in conjunction with the continued presence of a clustered settlement pattern like that of European Jewish communities during the medieval period, indicates that the Jews of the Caribbean were not fully integrated socially or politically into British colonial society. This examination of the Nevis community

  8. Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing.

    PubMed

    Suárez-Fariñas, Mayte; Ungar, Benjamin; Noda, Shinji; Shroff, Anjali; Mansouri, Yasaman; Fuentes-Duculan, Judilyn; Czernik, Annette; Zheng, Xiuzhong; Estrada, Yeriel D; Xu, Hui; Peng, Xiangyu; Shemer, Avner; Krueger, James G; Lebwohl, Mark G; Guttman-Yassky, Emma

    2015-11-01

    Alopecia areata (AA) is a common T cell-mediated disorder with limited therapeutics. A molecular profile of cytokine pathways in AA tissues is lacking. Although studies have focused on TH1/IFN-γ responses, several observations support a shared genetic background between AA and atopy. We sought to define the AA scalp transcriptome and associated biomarkers with comparisons with atopic dermatitis (AD) and psoriasis. We performed microarray and RT-PCR profiling of 27 lesional and 17 nonlesional scalp samples from patients with AA for comparison with normal scalp samples (n = 6). AA gene expression was also compared with samples from patients with lesional or nonlesional AD and those with psoriasis. A fold change of greater than 1.5 and a false discovery rate of less than 0.05 were used for differentially expressed genes (DEGs). We established the AA transcriptomes (lesional vs nonlesional: 734 DEGs [297 upregulated and 437 downregulated]; lesional vs normal: 4230 DEGs [1980 upregulated and 2250 downregulated]), including many upregulated immune and downregulated hair keratin genes. Equally impressive as upregulation in TH1/interferon markers (IFNG and CXCL10/CXCL9) were those noted in TH2 (IL13, CCL18, CCL26, thymic stromal lymphopoietin, and periostin), TH9/IL-9, IL-23 (p40 and p19), and IL-16 mediators (all P < .05). There were no increases in TH17/TH22 markers. Hair keratin (KRT) expressions (ie, KRT86 and KRT85) were significantly suppressed in lesional skin. Greater scalp involvement (>25%) was associated with greater immune and keratin dysregulation and larger abnormalities in nonlesional scalp samples (ie, CXCL10 and KRT85). Our data associate the AA signature with TH2, TH1, IL-23, and IL-9/TH9 cytokine activation, suggesting consideration of anti-TH2, anti-TH1, and anti-IL-23 targeting strategies. Similar to psoriasis and AD, clinical trials with selective antagonists are required to dissect key pathogenic pathways. Copyright © 2015 American Academy of

  9. Quantifying early 17th century changes in Chesapeake Bay estuarine carbon dynamics from James River, VA oyster geochemistry

    NASA Astrophysics Data System (ADS)

    Grimm, B. L.; Spero, H. J.; Harding, J. M.

    2012-12-01

    same shells provide seasonal signals and also show an offset from modern that is consistent with drought conditions during the early 17th century. These high fidelity records allow for a direct, high-resolution comparison of the residence time of carbon in the environment immediately prior to European colonization and during the first century of land use change in mid-Atlantic North America.

  10. Cosmic ray composition between 10 to the 15th power - 10 to the 17th power eV obtained by air shower experiments

    NASA Technical Reports Server (NTRS)

    Muraki, Y.

    1985-01-01

    Based on the air shower data, the chemical composition of the primary cosmic rays in the energy range 10 to the 15th power - 10 to the 17th power eV was obtained. The method is based on a well known N sub e-N sub mu and N sub e-N sub gamma. The simulation is calibrated by the CERN SPS pp collider results.

  11. Proceedings of the Symposium on Electromagnetic Windows (17th) Held at Georgia Institute of Technology, Engineering Experiment Station, Atlanta, Georgia on 25-27 July 1984. Part 1

    DTIC Science & Technology

    1984-09-01

    00 George H. Adams Department of Continuing Education September 1984 0-I U. S. Army Research Office P. 0. No. 84-M-0346 GEORGIA INSTITUTE OF TECHNOLOGY...ATLANTA, GEORGIA 30332 r ) (ELEctEK D JN22 1985 APPROvED FOR PUBLIC RELEASE 91STRIBUTION UNLIMITED 7 .7 .7 7rr - COMPONENT PART NOTICE THIS PAPER IS...A COMPONENT PART OF THE FOLLOWING COMPILATION REPORT: (TITLE): Proceedingzs of the Symposium on Electromagnetic Windows (17th) Held at Georgia

  12. Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome.

    PubMed

    Zhang, Lei; Wang, Ting; Wang, Xiao-qi; Du, Rui-zhi; Zhang, Kai-ning; Liu, Xin-guang; Ma, Dao-xin; Yu, Shuang; Su, Guo-hai; Li, Zhen-hua; Guan, Yu-qing; Du, Nai-li

    2013-01-01

    Atherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4(+) T cells that secret IL-22 but not IL-17 or IFN-γ and are implicated in the pathogenesis of inflammatory disease. The roles of Th22 cells in the pathophysiologic procedures of acute coronary syndrome (ACS) remain unclear. The purpose of this study is to investigate the profile of Th22, Th17 and Th17/Th1 cells in ACS patients, including unstable angina (UA) and acute myocardial infarction (AMI) patients. In this study, 26 AMI patients, 16 UA patients, 16 stable angina (SA) patients and 16 healthy controls were included. The frequencies of Th22, Th17 and Th17/Th1 cells in AMI, UA, SA patients and healthy controls were examined by flow cytometry. Plasma levels of IL-22, IL-17 and IFN-γ were measured by enzyme-linked immunosorbent assay (ELISA). Th22, Th17 and Th17/Th1 cells were significantly increased in AMI and UA patients compared with SA patients and healthy controls. Moreover, plasma IL-22 level was significantly elevated in AMI and UA patients. In addition, Th22 cells correlated positively with IL-22 as well as Th17 cells in AMI and UA patients. Our findings showed increased frequencies of both Th22 and Th17 cells in ACS patients, which suggest that Th22 and Th17 cells may play a potential role in plaque destabilization and the development of ACS.

  13. World

    NASA Astrophysics Data System (ADS)

    Kilinc, M.; Beringer, J.; Hutley, L.; Kurioka, K.; Wood, S.; D'Argent, N.; Martin, D.; McHugh, I.; Tapper, N.; McGuire, D.

    2009-04-01

    Natural forests store vast amounts of carbon in the terrestrial biosphere, and play an important role in the global carbon cycle. Given the significance of natural forests, there is a lack of carbon accounting of primary forests that are undisturbed by human activities. One reason for this lack of interest stems from ecological orthodoxy that suggests that primary forests should be close to dynamic equilibrium, in that Net Ecosystem Production (NEP) approaches zero. However, recent results from the northern hemisphere and tropics, using eddy covariance flux towers, indicate that primary forests are a greater sink than first thought. The role of evergreen primary forests in Australian carbon balance studies remain uncertain and hence may function differently to their deciduous counterparts in the Northern Hemisphere. In order to address the lack of baseline carbon accounts, an undisturbed, 300 year old Mountain Ash (Eucalyptus regnans) ecosystem, located in the Central Highlands of Victoria (Australia) was selected as a permanent study site to investigate carbon and water budgets over diurnal, seasonal and annual cycles. Mountain Ash trees are the world's tallest angiosperms (flowering plants), and one of the largest carbon reservoirs in the biosphere, with an estimated 1900 tC ha-1. A 110 m tall micrometeorological tower that includes eddy covariance instrumentation was installed in August 2005. An independent biometric approach quantifying the annual net gain or loss of carbon was also made within close proximity to the flux tower. Analysis of NEP in 2006 suggests that the ecosystem acted as a carbon sink of 2.5 tC ha-1 yr-1. Woody and soil biomass increment for the same year was estimated to be 2.8 tC ha-1yr-1, in which nearly half of the biomass production was partitioned into the aboveground woody tissue. These results indicate that temperate primary forests act as carbon sinks, and are able to maintain their carbon sink status due to their uneven stand

  14. Spider World: A Robot Language for Learning to Program. Assessing the Cognitive Consequences of Computer Environments for Learning (ACCCEL).

    ERIC Educational Resources Information Center

    Dalbey, John; Linn, Marcia

    Spider World is an interactive program designed to help individuals with no previous computer experience to learn the fundamentals of programming. The program emphasizes cognitive tasks which are central to programming and provides significant problem-solving opportunities. In Spider World, the user commands a hypothetical robot (called the…

  15. Effects of Learning Style and Training Method on Computer Attitude and Performance in World Wide Web Page Design Training.

    ERIC Educational Resources Information Center

    Chou, Huey-Wen; Wang, Yu-Fang

    1999-01-01

    Compares the effects of two training methods on computer attitude and performance in a World Wide Web page design program in a field experiment with high school students in Taiwan. Discusses individual differences, Kolb's Experiential Learning Theory and Learning Style Inventory, Computer Attitude Scale, and results of statistical analyses.…

  16. A Computing Environment to Support Repeatable Scientific Big Data Experimentation of World-Wide Scientific Literature

    SciTech Connect

    Schlicher, Bob G; Kulesz, James J; Abercrombie, Robert K; Kruse, Kara L

    2015-01-01

    A principal tenant of the scientific method is that experiments must be repeatable and relies on ceteris paribus (i.e., all other things being equal). As a scientific community, involved in data sciences, we must investigate ways to establish an environment where experiments can be repeated. We can no longer allude to where the data comes from, we must add rigor to the data collection and management process from which our analysis is conducted. This paper describes a computing environment to support repeatable scientific big data experimentation of world-wide scientific literature, and recommends a system that is housed at the Oak Ridge National Laboratory in order to provide value to investigators from government agencies, academic institutions, and industry entities. The described computing environment also adheres to the recently instituted digital data management plan mandated by multiple US government agencies, which involves all stages of the digital data life cycle including capture, analysis, sharing, and preservation. It particularly focuses on the sharing and preservation of digital research data. The details of this computing environment are explained within the context of cloud services by the three layer classification of Software as a Service , Platform as a Service , and Infrastructure as a Service .

  17. Elevated Frequencies of Circulating Th22 Cell in Addition to Th17 Cell and Th17/Th1 Cell in Patients with Acute Coronary Syndrome

    PubMed Central

    Zhang, Lei; Wang, Ting; Wang, Xiao-qi; Du, Rui-zhi; Zhang, Kai-ning; Liu, Xin-guang; Ma, Dao-xin; Yu, Shuang; Su, Guo-hai; Li, Zhen-hua; Guan, Yu-qing; Du, Nai-li

    2013-01-01

    Background Atherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4+ T cells that secret IL-22 but not IL-17 or IFN-γ and are implicated in the pathogenesis of inflammatory disease. The roles of Th22 cells in the pathophysiologic procedures of acute coronary syndrome (ACS) remain unclear. The purpose of this study is to investigate the profile of Th22, Th17 and Th17/Th1 cells in ACS patients, including unstable angina (UA) and acute myocardial infarction (AMI) patients. Design and Methods In this study, 26 AMI patients, 16 UA patients, 16 stable angina (SA) patients and 16 healthy controls were included. The frequencies of Th22, Th17 and Th17/Th1 cells in AMI, UA, SA patients and healthy controls were examined by flow cytometry. Plasma levels of IL-22, IL-17 and IFN-γ were measured by enzyme-linked immunosorbent assay (ELISA). Results Th22, Th17 and Th17/Th1 cells were significantly increased in AMI and UA patients compared with SA patients and healthy controls. Moreover, plasma IL-22 level was significantly elevated in AMI and UA patients. In addition, Th22 cells correlated positively with IL-22 as well as Th17 cells in AMI and UA patients. Conclusion Our findings showed increased frequencies of both Th22 and Th17 cells in ACS patients, which suggest that Th22 and Th17 cells may play a potential role in plaque destabilization and the development of ACS. PMID:24312440

  18. [The beginnings of the nursing profession : the complementary relationship between secular caregivers and hospital nuns in France in the 17th and 18th centuries].

    PubMed

    Diebolt, Evelyne

    2013-06-01

    The words used for designating the caregivers are ambiguous. Little by little, the word "nurse" becomes widely used, mainly in the feminine form due to the need of specialized staff. Health care structures are developing in the 17th and 18 centuries, the remains of which you can find in today hospitals (Salpêtrière hospital, Hôtel-Dieu hospital in Paris). The government of Louis XIV cares for the poor sick people, the vagabonds and the beggars. It opens new general hospitals as it will be the case later in all Europe. In the 17th century, the staff of the general hospital in Paris is entirely secular. The Paris general hospital is headed by the magistrates of Paris Parliament. The healthcare institutions employ both secular and religious staff for example the Hotel Dieu in Paris and the one in Marseilles. In the 17th century, there are 2000 secular caregivers in France. The order of the "Filles de la Charité" (grey sisters) is not submitted to the rule of enclosure. They renew their vows every year. For their founders Vincent de Paul and Louise de Marcillac, their monastery should be the cells of the sick, their cloister should be the rooms of the hospitals or the streets of the town. The secular or religious caregivers are excellent in the apothecary and they open a network of small dispensaries. It improves the health of the French population and allows fighting against the epidemics. This activity allowed some women to have a rewarding activity and a social status of which they were apparently satisfied.

  19. Portuguese tin-glazed earthenware from the 17th century. Part 2: A spectroscopic characterization of pigments, glazes and pastes of the three main production centers.

    PubMed

    Vieira Ferreira, L F; Ferreira, D P; Conceição, D S; Santos, L F; Pereira, M F C; Casimiro, T M; Ferreira Machado, I

    2015-01-01

    Sherds representative of the three Portuguese faience production centers of the 17th century - Lisbon, Coimbra and Vila Nova were studied with the use of mostly non-invasive spectroscopies, namely: ground state diffuse reflectance absorption (GSDR), micro-Raman, Fourier-transform infrared (FT-IR) and proton induced X-ray (PIXE) or X-ray fluorescence emission (XRF). X-ray diffraction (XRD) experiments were also performed. The obtained results evidence a clear similarity in the pastes of the pottery produced Vila Nova and some of the ceramic pastes from Lisbon, in accordance with documental sources that described the use of Lisbon clays by Vila Nova potters, at least since mid 17th century. Quartz and Gehlenite are the main components of the Lisbon's pastes, but differences between the ceramic pastes were detected pointing out to the use of several clay sources. The spectroscopic trend exhibited Coimbra's pottery is remarkably different, Quartz and Diopside being the major components of these pastes, enabling one to well define a pattern for these ceramic bodies. The blue pigment from the Lisbon samples is a cobalt oxide that exists in the silicate glassy matrix, which enables the formation of detectable cobalt silicate microcrystals in most productions of the second half of the 17th century. No micro-Raman cobalt blue signature could be detected in the Vila Nova and Coimbra blue glazes. This is in accordance with the lower kiln temperatures in these two production centers and with Co(2+) ions dispersed in the silicate matrix. In all cases the white glaze is obtained with the use of tin oxide. Hausmannite was detected as the manganese oxide mineral used to produce the purple glaze (wine color "vinoso") in Lisbon. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. [The magic universe of cures: the role of magic practices and witchcraft in the universe of 17th century Mato Grosso].

    PubMed

    Sá, Mario

    2009-01-01

    The article analyzes the role of healing agents played by practitioners of magic and witchcraft in Mato Grosso society during the 17th century. It observes that magic and witchcraft were developed as competitors, alternatives or associated with other forms of healing (official and lay). It points out how such roles contributed to the process of subjugating its practitioners, especially Africans, Indians and their descendents, and were appropriated as an opportunity for survival in the colonial slave society. The pastoral visit made by Bruno Pinna in 1785 to Cuiabá and nearby areas served as the principal source of knowledge regarding the practices and practitioners of magic and witchcraft.

  1. Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th century China

    NASA Astrophysics Data System (ADS)

    Cigola, Michela; Fang, Yibing

    2016-03-01

    This study aims to investigate the role played by Xu Guangqi (1562-1633), minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa ( On Western Hydraulics). Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes' screw and Ctesibius' machine, which are included in Vitruvius' De Architectura volumes, also appear in the work of Xu Guangqi.

  2. Determination of droughts and high floods of the Bermejo River (Argentina) based on documentary evidence (17th to 20th century)

    NASA Astrophysics Data System (ADS)

    Prieto, M. R.; Rojas, F.

    2015-10-01

    This study reconstructs a series of droughts and high flow volumes of the Bermejo River from the 17th to 20th century based on a content analysis of historic documentary evidence, which is calibrated with instrumental climate data. The historic data series shows an increase in the frequency of extraordinarily high waters beginning in the 19th century and a significant decrease in extreme droughts beginning in 1890. The data are compared to variations in the Mendoza River for the same period, which show that there was a long-standing lack of correlation between the rivers.

  3. Multistep greedy algorithm identifies community structure in real-world and computer-generated networks

    NASA Astrophysics Data System (ADS)

    Schuetz, Philipp; Caflisch, Amedeo

    2008-08-01

    We have recently introduced a multistep extension of the greedy algorithm for modularity optimization. The extension is based on the idea that merging l pairs of communities (l>1) at each iteration prevents premature condensation into few large communities. Here, an empirical formula is presented for the choice of the step width l that generates partitions with (close to) optimal modularity for 17 real-world and 1100 computer-generated networks. Furthermore, an in-depth analysis of the communities of two real-world networks (the metabolic network of the bacterium E. coli and the graph of coappearing words in the titles of papers coauthored by Martin Karplus) provides evidence that the partition obtained by the multistep greedy algorithm is superior to the one generated by the original greedy algorithm not only with respect to modularity, but also according to objective criteria. In other words, the multistep extension of the greedy algorithm reduces the danger of getting trapped in local optima of modularity and generates more reasonable partitions.

  4. Data generation and data visualization using different platform computers in the World Wide Web environment

    NASA Astrophysics Data System (ADS)

    Chen, Philip C.

    1997-04-01

    At the IST and SPIE 96 conference, the author reported a successful cooperative visualization case study that involved using an internet web-browser for data dissemination and data visualization applications between the US and Japanese offices. This cooperative visualization effort using computers and the web-browser has been evaluated, and it has pointed the way to the current research involving the use of the World Wide Web environment for real-time simulation and interactive visualization. Since the spring of 1996, the author has been using Fujitsu's new multi-processor supercomputer VPP300 for fast numerical model simulations and data generations. Meanwhile, the web technology has been advancing very quickly, and it now provides many tools and methods for the scientific visualization. In the summer of 1996, the author began to work on a prototype for a real-time supercomputing interactive visualization system based on the available World Wide Web browser tools and a Fujitsu visualization software known as VisLink. The intranet version of this system was completed in December of 1997. Design issues and a case study of the prototype will be discussed in this paper.

  5. Discourse analysis of computer-mediated conferencing in World Wide Web-based continuing medical education.

    PubMed

    Curran, Vernon; Kirby, Fran; Parsons, Ean; Lockyer, Jocelyn

    2003-01-01

    Computer-mediated conferencing (CMC) is a computer messaging system that allows users to engage in asynchronous text-based communications that are independent of time and place. It has been suggested that CMC is an effective modality for facilitating constructivist learning environments that enable adult learners to engage in a continuous, collaborative process of building and reshaping knowledge and understanding. The goals of this exploratory study were to assess the nature of the interactions and collaborative learning characteristics exhibited in World Wide Web-based continuing medical education courseware programs that used CMC and to examine physicians' satisfaction with on-line CMC discussion as a planned learning activity of Web-based CME. The Transcript Analysis Tool (TAT) was used to analyze the nature of the discourse that took place in four different Web-based CME courseware programs. Course evaluation surveys and interviews were also conducted with participants to evaluate their satisfaction with on-line CMC discussion. The results suggest that the nature of participation in the programs consisted primarily of independent messages with a minimal amount of learner-to-learner interaction. Elements of critical reflection, interaction, and debate between participants appeared to be missing from these discussions. As such, these discussions were not characteristic of the principles of constructivist learning environments. Interactive participation will not occur just because CMC is being used. The design of Web-based CME learning activities, participant characteristics, and facilitation are key factors that influence the effective use of CMC.

  6. Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease.

    PubMed

    Ryan-Payseur, Bridgett; Ali, Zahida; Huang, Dan; Chen, Crystal Y; Yan, Lin; Wang, Richard C; Collins, William E; Wang, Yunqi; Chen, Zheng W

    2011-11-01

    Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. We tested this hypothesis by employing macaque models of coinfection with malaria and simian-human immunodeficiency virus (SHIV). Plasmodium fragile malaria coinfection of acutely SHIV-infected macaques induced hyperimmune activation and remarkable expansion of CD4+ and CD8+ T effector cells de novo producing interferon γ or tumor necrosis factor α. Malaria-driven cellular hyperactivation/expansion and high-level Th1-cytokines enhanced SHIV disease characterized by increasing CD4+ T-cell depletion, profound lymphoid depletion or destruction, and even necrosis in lymph nodes and spleens. Importantly, malaria/SHIV-mediated depletion, destruction, and necrosis in lymphoid tissues led to bursting parasite replication and fatal virus-associated malaria. Surprisingly, chronically SHIV-infected macaques without AIDS employed different defense mechanisms during malaria coinfection, and mounted unique ∼200-fold expansion of interleukin 17+/interleukin 22+ T effectors with profound Th1 suppression. Such remarkable expansion of Th17/Th22 cells and inhibition of Th1 response coincided with development of immunity against fatal virus-associated malaria without accelerating SHIV disease. These novel findings suggest that virus infection status and selected Th1 or Th17/Th22 responses after malaria/AIDS-virus coinfection correlate with distinct outcomes of virus infection and malaria.

  7. Visualizing the 17th century underpainting in Portrait of an Old Man by Rembrandt van Rijn using synchrotron-based scanning macro-XRF

    NASA Astrophysics Data System (ADS)

    Alfeld, Matthias; Siddons, D. Peter; Janssens, Koen; Dik, Joris; Woll, Arthur; Kirkham, Robin; van de Wetering, Ernst

    2013-04-01

    In 17th century Old Master Paintings, the underpainting generally refers to the first sketch of a composition. The underpainting is applied to a prepared ground using a monochrome, brown oil paint to roughly indicate light, shade and contours. So far, methods to visualize the underpainting—other than in localized cross-sections—have been very limited. Neither infrared reflectography nor neutron induced autoradiography have proven to be practical, adequate visualization tools. Thus, although of fundamental interest in the understanding of a painting's genesis, the underpainting has virtually escaped all imaging efforts. In this contribution we will show that 17th century underpainting may consist of a highly heterogeneous mixture of pigments, including copper pigments. We suggest that this brown pigment mixture is actually the recycled left-over of a palette scraping. With copper as the heaviest exclusive elemental component, we will hence show in a case study on a Portrait of an Old Man attributed to Rembrandt van Rijn how scanning macro-XRF can be used to efficiently visualize the underpainting below the surface painting and how this information can contribute to the discussion of the painting's authenticity.

  8. International Symposium on Space Technology and Science, 17th, Tokyo, Japan, May 20-25, 1990, Proceedings. Vols. 1 & 2

    NASA Astrophysics Data System (ADS)

    Kuriki, Kyoichi

    Various papers on space technology and science are presented. The general topics addressed include: national space programs; propulsion; materials and structure, flight dynamics and astrodynamics; fluid dynamics; thermal environment and thermochemistry; electronic components and devices; computer and data systems; guidance, navigation, and control; robotics; systems engineering. Also discussed are: space transportation systems; spacecraft systems; space station and manned flight; balloons; satellite communications and broadcasting; lunar and planetary exploration; space science; earth observations; space medicine; space biology; microgravity; space industrialization; space law and international cooperation.

  9. Using the computer-driven VR environment to promote experiences of natural world immersion

    NASA Astrophysics Data System (ADS)

    Frank, Lisa A.

    2013-03-01

    In December, 2011, over 800 people experienced the exhibit, <1>:"der"//pattern for a virtual environment, created for the fully immersive CAVETM at the University of Wisconsin-Madison. This exhibition took my nature-based photographic work and reinterpreted it for virtual reality (VR).Varied responses such as: "It's like a moment of joy," or "I had to see it twice," or "I'm still thinking about it weeks later" were common. Although an implied goal of my 2D artwork is to create a connection that makes viewers more aware of what it means to be a part of the natural world, these six VR environments opened up an unexpected area of inquiry that my 2D work has not. Even as the experience was mediated by machines, there was a softening at the interface between technology and human sensibility. Somehow, for some people, through the unlikely auspices of a computer-driven environment, the project spoke to a human essence that they connected with in a way that went beyond all expectations and felt completely out of my hands. Other interesting behaviors were noted: in some scenarios some spoke of intense anxiety, acrophobia, claustrophobia-even fear of death when the scene took them underground. These environments were believable enough to cause extreme responses and disorientation for some people; were fun, pleasant and wonder-filled for most; and were liberating, poetic and meditative for many others. The exhibition seemed to promote imaginative skills, creativity, emotional insight, and environmental sensitivity. It also revealed the CAVETM to be a powerful tool that can encourage uniquely productive experiences. Quite by accident, I watched as these nature-based environments revealed and articulated an essential relationship between the human spirit and the physical world. The CAVETM is certainly not a natural space, but there is clear potential to explore virtual environments as a path to better and deeper connections between people and nature. We've long associated

  10. What could you do with 400 years of biological history on african americans? Evaluating the potential scientific benefit of systematic studies of dental and skeletal materials on African Americans from the 17th through 20th centuries

    PubMed Central

    Jackson, Latifa; Cross, Christopher; Clarke, Cameron

    2016-01-01

    Objectives How important is it to be able to reconstruct the lives of a highly diverse, historically recent macroethnic group over the course of 400 years? How many insights into human evolutionary biology and disease susceptibilities could be gained, even with this relatively recent window into the past? In this article, we explore the potential ramifications of a newly constructed dataset of Four Centuries of African American Biological Variation (4Cs). Methods This article provides initial lists of digitized variables formatted as SQL tables for the 17th and 18th century samples and for the 19th and 20th century samples. Results This database is dynamic and new information is added yearly. The database provides novel opportunities for significant insights into the past biological history of this group and three case study applications are detailed for comparative computational systems biology studies of (1) hypertension, (2) the oral microbiome, and (3) mental health disorders. Conclusions The 4Cs dataset is ideal for interdisciplinary “next generation” science research and these data represent a unique step toward the accumulation of historically contextualized Big Data on an underrepresented group known to have experienced differential survival over time. Am. J. Hum. Biol. 28:510–513, 2016. © 2016 The Authors American Journal of Human Biology Published byWiley Periodicals, Inc. PMID:26749025

  11. The phylogeographic history of the new world screwworm fly, inferred by approximate bayesian computation analysis.

    PubMed

    Fresia, Pablo; Azeredo-Espin, Ana Maria L; Lyra, Mariana L

    2013-01-01

    Insect pest phylogeography might be shaped both by biogeographic events and by human influence. Here, we conducted an approximate Bayesian computation (ABC) analysis to investigate the phylogeography of the New World screwworm fly, Cochliomyia hominivorax, with the aim of understanding its population history and its order and time of divergence. Our ABC analysis supports that populations spread from North to South in the Americas, in at least two different moments. The first split occurred between the North/Central American and South American populations in the end of the Last Glacial Maximum (15,300-19,000 YBP). The second split occurred between the North and South Amazonian populations in the transition between the Pleistocene and the Holocene eras (9,100-11,000 YBP). The species also experienced population expansion. Phylogenetic analysis likewise suggests this north to south colonization and Maxent models suggest an increase in the number of suitable areas in South America from the past to present. We found that the phylogeographic patterns observed in C. hominivorax cannot be explained only by climatic oscillations and can be connected to host population histories. Interestingly we found these patterns are very coincident with general patterns of ancient human movements in the Americas, suggesting that humans might have played a crucial role in shaping the distribution and population structure of this insect pest. This work presents the first hypothesis test regarding the processes that shaped the current phylogeographic structure of C. hominivorax and represents an alternate perspective on investigating the problem of insect pests.

  12. The Phylogeographic History of the New World Screwworm Fly, Inferred by Approximate Bayesian Computation Analysis

    PubMed Central

    Azeredo-Espin, Ana Maria L.

    2013-01-01

    Insect pest phylogeography might be shaped both by biogeographic events and by human influence. Here, we conducted an approximate Bayesian computation (ABC) analysis to investigate the phylogeography of the New World screwworm fly, Cochliomyia hominivorax, with the aim of understanding its population history and its order and time of divergence. Our ABC analysis supports that populations spread from North to South in the Americas, in at least two different moments. The first split occurred between the North/Central American and South American populations in the end of the Last Glacial Maximum (15,300-19,000 YBP). The second split occurred between the North and South Amazonian populations in the transition between the Pleistocene and the Holocene eras (9,100-11,000 YBP). The species also experienced population expansion. Phylogenetic analysis likewise suggests this north to south colonization and Maxent models suggest an increase in the number of suitable areas in South America from the past to present. We found that the phylogeographic patterns observed in C. hominivorax cannot be explained only by climatic oscillations and can be connected to host population histories. Interestingly we found these patterns are very coincident with general patterns of ancient human movements in the Americas, suggesting that humans might have played a crucial role in shaping the distribution and population structure of this insect pest. This work presents the first hypothesis test regarding the processes that shaped the current phylogeographic structure of C. hominivorax and represents an alternate perspective on investigating the problem of insect pests. PMID:24098436

  13. Utilization of Computer Technology in the Third World: An Evaluation of Computer Operations at the University of Honduras.

    ERIC Educational Resources Information Center

    Shermis, Mark D.

    This report of the results of an evaluation of computer operations at the University of Honduras (Universidad Nacional Autonoma de Honduras) begins by discussing the problem--i.e., poor utilization of the campus mainframe computer--and listing the hardware and software available in the computer center. Data collection methods are summarized,…

  14. Computer-Based Information Systems Education in the Arab World: A Survey.

    ERIC Educational Resources Information Center

    Noor, A. El Sayed

    1983-01-01

    This state-of-the-art review of computing sciences education in the Arab countries, including computer engineering, computer science, and computer-based management information systems, discusses factors contributing to the widening gap in computing expertise between the Arab countries and the developed countries. (EAO)

  15. On the Chemical Signature and Origin of Dicoppertrihydroxyformate (Cu2(OH)3HCOO) Formed on Copper Miniatures of 17th and 18th centuries.

    PubMed

    Veiga, Alfredina; Teixeira, Dora Martins; Candeias, António J; Mirão, José; Rodrigues, Paulo Simões; Teixeira, Jorge Ginja

    2016-10-01

    A corrosion product rarely reported in the literature has been found on the copper support of three miniature paintings of the 17th and 18th centuries. This product, which has been identified as dicoppertrihydroxyformate (Cu2(OH)3HCOO), is an unusual basic copper formate found on copper artifacts. The identification and characterization of dicoppertrihydroxyformate was carried out directly over the corroded surface of the objects, using a nondestructive approach, which combines the integrated use of various microanalytical techniques. Using this approach, it was possible to obtain a set of new reference data about the natural form of Cu2(OH)3HCOO, that will enable its unambiguous identification in other similar objects. In this work, the probable causes that may have contributed to its formation are also discussed.

  16. [[The apothecaries of the district of Les Halles in Paris in the 17th century. Molière's ancestors in Les Halles].

    PubMed

    Warolin, Christian

    2016-03-01

    Les Halles were created by King Louis VI at the begining of the 12th century as a central market for food and trade. Apothecaries conducted their trade there from that time. In the 17th century, eleven apothecaries were established in this district, bordered on the south by the rue Saint-Honoré, on the east by the rue Saint-Denis, on the west by the rue de la Tonnellerie, and the north by the rue Montmartre. Their biographies have been analysed, and the data that has been collected has enabled their précise location to be fixed on a map of 1700. Molière's ancestors, both maternal (the Cressé family) and paternal (the Pocquelin's), lived in this district. Details of their relationships with their apothecary neighbours have been revealed.

  17. Historical and Metallurgical Characterization of a "Falchion" Sword Manufactured in Caino (Brescia, Italy) in the Early 17th Century A.D.

    NASA Astrophysics Data System (ADS)

    Tonelli, G.; Faccoli, M.; Gotti, R.; Roberti, R.; Cornacchia, G.

    2016-08-01

    A historical and metallurgical characterization of a "falchion" sword manufactured in Caino (Brescia, northern Italy) and dating from the early 17th century was performed to understand the manufacture methods of a Renaissance sword. At first, a set of size measurements was carried out to look for the existence of constant and/or recurring macroscopic sizes, which would indicate a standardized production, or of any type of proportionality between different parts of a sword, which would prove an intentional design activity. Light optical microscopy, scanning electron microscopy, energy-dispersive x-ray spectroscopy, quantometer analyses, and Vickers microhardness tests were then employed to analyze the microstructure and obtain the mechanical properties. All the metallurgical work is supported by an accurate study on the chemical composition of both metal-matrix and nonmetallic inclusions, which allowed for rebuilding and evaluating the efficiency of the whole production process.

  18. Collaborations in population-based health research: the 17th annual HMO Research Network Conference, March 23-25, 2011, Boston, Massachusetts, USA.

    PubMed

    Lieu, Tracy A; Hinrichsen, Virginia L; Moreira, Andrea; Platt, Richard

    2011-11-01

    The HMO Research Network (HMORN) is a consortium of 16 health care systems with integrated research centers. Approximately 475 people participated in its 17(th) annual conference, hosted by the Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School. The theme, "Collaborations in Population-Based Health Research," reflected the network's emphasis on collaborative studies both among its members and with external investigators. Plenary talks highlighted the initial phase of the HMORN's work to establish the NIH-HMO Collaboratory, opportunities for public health collaborations, the work of early career investigators, and the state of the network. Platform and poster presentations showcased a broad spectrum of innovative public domain research in areas including disease epidemiology and treatment, health economics, and information technology. Special interest group sessions and ancillary meetings provided venues for informal conversation and structured work among ongoing groups, including networks in cancer, cardiovascular diseases, lung diseases, medical product safety, and mental health.

  19. [Discourse on the social illness: leprosy in the Viceroyalty of Nueva Granada in the transition from the 17th to the 18th century (Spanish)].

    PubMed

    Sabater, P G

    1999-01-01

    The significance of leprosy in the Viceroyalty of Nueva Granada in the transition from the 17th to the 18th century is analyzed. In addition, we analyze treatments recommended by physicians in the viceroyalty, which were closely related with the etiology and pathogenesis which all doctors attributed to Saint Lazarus's disease. The diversity of opinions led to different therapeutic measures, not only with regard to alleviating the patient's symptoms, but also with a view to preventing it to spread to the rest of the population. As a guiding theme we use the theories defended by the most representative physicians in the viceroyalty, and the views of patients themselves and the society they lived in.

  20. Computational Scientific Inquiry with Virtual Worlds and Agent-Based Models: New Ways of Doing Science to Learn Science

    ERIC Educational Resources Information Center

    Jacobson, Michael J.; Taylor, Charlotte E.; Richards, Deborah

    2016-01-01

    In this paper, we propose computational scientific inquiry (CSI) as an innovative model for learning important scientific knowledge and new practices for "doing" science. This approach involves the use of a "game-like" virtual world for students to experience virtual biological fieldwork in conjunction with using an agent-based…

  1. Computational Scientific Inquiry with Virtual Worlds and Agent-Based Models: New Ways of Doing Science to Learn Science

    ERIC Educational Resources Information Center

    Jacobson, Michael J.; Taylor, Charlotte E.; Richards, Deborah

    2016-01-01

    In this paper, we propose computational scientific inquiry (CSI) as an innovative model for learning important scientific knowledge and new practices for "doing" science. This approach involves the use of a "game-like" virtual world for students to experience virtual biological fieldwork in conjunction with using an agent-based…

  2. Virus Infection Stages and Distinct Th1 or Th17/Th22 T-Cell Responses in Malaria/SHIV Coinfection Correlate with Different Outcomes of Disease

    PubMed Central

    Ryan-Payseur, Bridgett; Ali, Zahida; Huang, Dan; Chen, Crystal Y.; Yan, Lin; Wang, Richard C.; Collins, William E.; Wang, Yunqi

    2011-01-01

    Background. Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. Methods. We tested this hypothesis by employing macaque models of coinfection with malaria and simian-human immunodeficiency virus (SHIV). Results. Plasmodium fragile malaria coinfection of acutely SHIV-infected macaques induced hyperimmune activation and remarkable expansion of CD4+ and CD8+ T effector cells de novo producing interferon γ or tumor necrosis factor α. Malaria-driven cellular hyperactivation/expansion and high-level Th1-cytokines enhanced SHIV disease characterized by increasing CD4+ T-cell depletion, profound lymphoid depletion or destruction, and even necrosis in lymph nodes and spleens. Importantly, malaria/SHIV-mediated depletion, destruction, and necrosis in lymphoid tissues led to bursting parasite replication and fatal virus-associated malaria. Surprisingly, chronically SHIV-infected macaques without AIDS employed different defense mechanisms during malaria coinfection, and mounted unique ∼200-fold expansion of interleukin 17+/interleukin 22+ T effectors with profound Th1 suppression. Such remarkable expansion of Th17/Th22 cells and inhibition of Th1 response coincided with development of immunity against fatal virus-associated malaria without accelerating SHIV disease. Conclusions. These novel findings suggest that virus infection status and selected Th1 or Th17/Th22 responses after malaria/AIDS-virus coinfection correlate with distinct outcomes of virus infection and malaria. PMID:21921207

  3. Towards a Global Service Registry for the World-Wide LHC Computing Grid

    NASA Astrophysics Data System (ADS)

    Field, Laurence; Alandes Pradillo, Maria; Di Girolamo, Alessandro

    2014-06-01

    The World-Wide LHC Computing Grid encompasses a set of heterogeneous information systems; from central portals such as the Open Science Grid's Information Management System and the Grid Operations Centre Database, to the WLCG information system, where the information sources are the Grid services themselves. Providing a consistent view of the information, which involves synchronising all these informations systems, is a challenging activity that has lead the LHC virtual organisations to create their own configuration databases. This experience, whereby each virtual organisation's configuration database interfaces with multiple information systems, has resulted in the duplication of effort, especially relating to the use of manual checks for the handling of inconsistencies. The Global Service Registry aims to address this issue by providing a centralised service that aggregates information from multiple information systems. It shows both information on registered resources (i.e. what should be there) and available resources (i.e. what is there). The main purpose is to simplify the synchronisation of the virtual organisation's own configuration databases, which are used for job submission and data management, through the provision of a single interface for obtaining all the information. By centralising the information, automated consistency and validation checks can be performed to improve the overall quality of information provided. Although internally the GLUE 2.0 information model is used for the purpose of integration, the Global Service Registry in not dependent on any particular information model for ingestion or dissemination. The intention is to allow the virtual organisation's configuration databases to be decoupled from the underlying information systems in a transparent way and hence simplify any possible future migration due to the evolution of those systems. This paper presents the Global Service Registry architecture, its advantages compared to the

  4. Call of the North. NECC '96: Proceedings of the Annual National Educational Computing Conference (17th, Minneapolis, Minnesota, June 11-13, 1996).

    ERIC Educational Resources Information Center

    Ingham, Donella, Ed.

    These conference proceedings address the current trends, practices, and research in the field of educational technology. Papers and project descriptions are included on the following topics: the use of technology to encourage learning of special needs students; distance education; integrating technology into the curriculum; technology in…

  5. Bridging the Two Worlds: A Universal Interface between Enzymatic and DNA Computing Systems.

    PubMed

    Mailloux, Shay; Gerasimova, Yulia V; Guz, Nataliia; Kolpashchikov, Dmitry M; Katz, Evgeny

    2015-05-26

    Molecular computing based on enzymes or nucleic acids has attracted a great deal of attention due to the perspectives of controlling living systems in the way we control electronic computers. Enzyme-based computational systems can respond to a great variety of small molecule inputs. They have the advantage of signal amplification and highly specific recognition. DNA computing systems are most often controlled by oligonucleotide inputs/outputs and are capable of sophisticated computing as well as controlling gene expressions. Here, we developed an interface that enables communication of otherwise incompatible nucleic-acid and enzyme-computational systems. The enzymatic system processes small molecules as inputs and produces NADH as an output. The NADH output triggers electrochemical release of an oligonucleotide, which is accepted by a DNA computational system as an input. This interface is universal because the enzymatic and DNA computing systems are independent of each other in composition and complexity.

  6. 17th International Seapower Symposium

    DTIC Science & Technology

    2006-06-01

    Chapter 1 Welcoming Remarks Rear Admiral Jacob L. Shuford, U.S. Navy President, U.S. Naval War College .......................................... 1 ...T:\\Academic\\ISS\\Printer\\ISS17.vp Friday, June 30, 2006 10:05:11 AM Color profile: Disabled Composite Default screen 1 Welcoming Remarks Rear Admiral...certainly agree that much water has passed underneath the keel since ISS- 1 in the fall of 1969—and that we face significant new challenges. The title of the

  7. The 17th Transducer Workshop

    NASA Astrophysics Data System (ADS)

    1993-06-01

    This committee apprises the Telemetry Group (TG) of significant progress in the field of transducers used in telemetry systems; maintains any necessary liaison between the TG and the National Institute of Standards and Technology and their transducers' program or other related telemetry transducer efforts; coordinates TG activities with other professional technical groups; collects and passes on information on techniques of measurement, evaluation, reliability, calibration, reporting, and manufacturing; recommends uniform practices for calibration, testing, and evaluation of vehicular instrumentation components; and contributes to standards in the area of vehicular instrumentation.

  8. The May 17th, 2012 M4.8 earthquake near Timpson, east Texas: Was it natural or was it induced?

    NASA Astrophysics Data System (ADS)

    Brown, W. A.; Frohlich, C. A.; Ellsworth, W. L.; Luetgert, J. H.; Brunt, M. R.

    2012-12-01

    The May 17th, 2012 earthquake occurred in the early morning near Timpson, Texas, about 50 km NE of Nacogdoches, where it awakened numerous residents. The highest intensities of MMI VII occurred 5 km southwest of Timpson, where chimneys, fireplaces, and brick veneer siding suffered significant damage. This is the largest recorded earthquake in eastern Texas. Following the earthquake we installed three temporary seismographs in the epicentral area. Data from these instruments, from a permanent station in Nacogdoches (NATX), and from several temporary USArray stations allowed us to identify foreshocks and aftershocks, and obtain locations for these events. A review of the NATX seismograms revealed activity in the same location as early as April 2008. There were several foreshocks in 2010-2012; the largest, a M3.9 on May 10th, 2012, was widely felt. Following the May 17th mainshock there have been about a dozen aftershocks. The best-recorded event occurred on June 16th and its preferred location is about 3 km north of the highest-intensity area. The focal depth is poorly constrained by travel times. However, a depth of 4 km or less is consistent with S-P times of ~1.0 sec at one station and the observation of whispering gallery phases at a distance of ~30 km at station NATX. At all stations the range of S-P times for foreshocks and aftershock is only a few tenths of a second, indicating that all events originated from nearly the same focus. Four injection disposal wells are situated within a few km of the epicentral region. One of these wells has had monthly injection rates between 16,000 m3/mo and 64,000 m3/mo since 2007. In the Barnett Shale of Texas, seismic activity is sometimes associated with wells having maximum monthly rates exceeding 24,000 m3/mo. Thus it is possible that the Timpson earthquakes were induced by injection. Historical record indicates that in 1891 and 1981, well before injection began, M4.0 and M3.2 earthquakes occurred 80 km west, and 25 km

  9. Semantic network mapping of religious material: testing multi-agent computer models of social theories against real-world data.

    PubMed

    Lane, Justin E

    2015-11-01

    Agent-based modeling allows researchers to investigate theories of complex social phenomena and subsequently use the model to generate new hypotheses that can then be compared to real-world data. However, computer modeling has been underutilized in regard to the understanding of religious systems, which often require very complex theories with multiple interacting variables (Braxton et al. in Method Theory Study Relig 24(3):267-290, 2012. doi: 10.1163/157006812X635709 ; Lane in J Cogn Sci Relig 1(2):161-180, 2013). This paper presents an example of how computer modeling can be used to explore, test, and further understand religious systems, specifically looking at one prominent theory of religious ritual. The process is continuous: theory building, hypothesis generation, testing against real-world data, and improving the model. In this example, the output of an agent-based model of religious behavior is compared against real-world religious sermons and texts using semantic network analysis. It finds that most religious materials exhibit unique scale-free small-world properties and that a concept's centrality in a religious schema best predicts its frequency of presentation. These results reveal that there adjustments need to be made to existing models of religious ritual systems and provide parameters for future models. The paper ends with a discussion of implications for a new multi-agent model of doctrinal ritual behaviors as well as propositions for further interdisciplinary research concerning the multi-agent modeling of religious ritual behaviors.

  10. An early illustrated comparative anatomy of the brain: Samuel Collins' A Systeme of Anatomy (1685) and the emergence of comparative neurology in 17th century England.

    PubMed

    Kruger, Lawrence

    2004-09-01

    The concept of comparing of the brains of various animals and of individual human brains was launched in the last half of the 17th century in England and was much influenced by the formation of the European scientific societies and their attempts to guide naturalist observations into a new systematics. An ambitious attempt to document this trend in an extensively illustrated work of encyclopedic pretensions was the singular publication of Samuel Collins (1618-1710), an energetic anatomist and president of the Royal College of Physicians. His little known tow-volume folio presentation, written in teh vernacular for broad acceptance, contains the seeds of a science of comparative neurology with the largest collection of brain illustrations (as well as of other organ systems) attempted in his era. Although lacking the conceptual insight that might derive from a true "comparative" anatomy and an understanding of the relations of different animals, the handsome engravings exemplified the new direction of the 'enlightenment' of the scientific revolution and are discussed in teh context of relevant events of this period.

  11. Identification of resinous materials on 16th and 17th century reverse-glass objects by gas chromatography/mass spectrometry

    NASA Astrophysics Data System (ADS)

    Baumer, Ursula; Dietemann, Patrick; Koller, Johann

    2009-07-01

    Objects of hinterglasmalerei, reverse-glass paintings, are painted on the back side of glass panels. Obviously, the paint layers are applied in reverse order, starting with the uppermost layer. The finished hinterglas painting is viewed through the glass, thus revealing an impressive gloss and depth of colour. The binding media of two precious objects of hinterglasmalerei from the 16th and 17th century have been identified as almost exclusively resinous. Identification was performed by a special optimised analysis procedure, which is discussed in this paper: solvent extracts are analysed by gas chromatography/mass spectrometry, both with and without derivatisation or hydrolysis. In an additional step, oxalic acid is added to the methanol extracts prior to injection. This attenuates the peaks of the non-acidic compounds, whereas the acids elute with good resolution. The non-acidic compounds are emphasised after injection of the underivatised extracts. This approach minimises compositional changes caused by the sample preparation and derivatisation steps. Chromatograms of aged samples with a very complex composition are simplified, which allows a more reliable and straightforward identification of significant markers for various materials. The binding media of the hinterglas objects were thus shown to consist of mixtures of different natural resins, larch turpentine, heat-treated Pinaceae resin or mastic. Typical compounds of dragon's blood, a natural red resin, were also detectable in red glazes by the applied analysis routine. Identification of the binding media provides valuable information that can be used in the development of an adequate conservation treatment.

  12. Genotyping Yersinia pestis in Historical Plague: Evidence for Long-Term Persistence of Y. pestis in Europe from the 14th to the 17th Century.

    PubMed

    Seifert, Lisa; Wiechmann, Ingrid; Harbeck, Michaela; Thomas, Astrid; Grupe, Gisela; Projahn, Michaela; Scholz, Holger C; Riehm, Julia M

    2016-01-01

    Ancient DNA (aDNA) recovered from plague victims of the second plague pandemic (14th to 17th century), excavated from two different burial sites in Germany, and spanning a time period of more than 300 years, was characterized using single nucleotide polymorphism (SNP) analysis. Of 30 tested skeletons 8 were positive for Yersinia pestis-specific nucleic acid, as determined by qPCR targeting the pla gene. In one individual (MP-19-II), the pla copy number in DNA extracted from tooth pulp was as high as 700 gene copies/μl, indicating severe generalized infection. All positive individuals were identical in all 16 SNP positions, separating phylogenetic branches within nodes N07_N10 (14 SNPs), N07_N08 (SNP s19) and N06_N07 (s545), and were highly similar to previously investigated plague victims from other European countries. Thus, beside the assumed continuous reintroduction of Y. pestis from central Asia in multiple waves during the second pandemic, long-term persistence of Y. pestis in Europe in a yet unknown reservoir host has also to be considered.

  13. Composition of Façon de Venise glass from early 17th century London in comparison with luxury glass of the same age

    NASA Astrophysics Data System (ADS)

    Cagno, S.; De Raedt, I.; Jeffries, T.; Janssens, K.

    SEM-EDX and LA-ICP-MS analyses were performed on a set of early 17th century London glass fragments. The samples originate from two archaeological sites (Aldgate and Old Broad Street) where glass workshops were active in this period. The great majority of the samples are made of soda glass. Two distinct compositional groups are observed, each typical of one site of provenance. The samples originating from the Old Broad Street excavation feature a silica-soda-lime composition, with a moderate amount of potash. The samples from Aldgate are richer in potassium and feature higher amounts of trace elements such as Rb, Zr and Cu. The distinction between the two groups stems from different flux and silica sources used for glassmaking. A comparison with different European glass compositions of that time reveals no resemblance with genuine Venetian production, yet the composition of the Old Broad Street glass shows a close similarity to that of fragments produced `à la façon de Venise' in Antwerp at the end of the 16th century. This coincides with historical sources attesting the arrival of glassworkers from the Low Countries in England and suggests that a transfer of technology took place near the turn of the century.

  14. Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway.

    PubMed

    Robles, Ana I; Olsen, Karina Standahl; Tsui, Dana W T; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B; Krokan, Hans E; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf D

    2016-10-19

    The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The "1st International NTNU Symposium on Current and Future Clinical Biomarkers of Cancer: Innovation and Implementation", was held June 16th and 17th 2016, at the Knowledge Center of the St. Olavs Hospital in Trondheim, Norway, under the auspices of the Norwegian University of Science and Technology (NTNU) and the HUNT biobank and research center. The Symposium attracted approximately 100 attendees and invited speakers from 12 countries and 4 continents. In this Symposium original research and overviews on diagnostic, predictive and prognostic cancer biomarkers in serum, plasma, urine, pleural fluid and tumor, circulating tumor cells and bioinformatics as well as how to implement biomarkers in clinical trials were presented. Senior researchers and young investigators presented, reviewed and vividly discussed important new developments in the field of clinical biomarkers of cancer, with the goal of accelerating biomarker research and implementation. The excerpts of this symposium aim to give a cutting-edge overview and insight on some highly important aspects of clinical cancer biomarkers to-date to connect molecular innovation with clinical implementation to eventually improve patient care.

  15. Quantification of the Early Small-Scale Fishery in the North-Eastern Baltic Sea in the Late 17th Century

    PubMed Central

    Verliin, Aare; Ojaveer, Henn; Kaju, Katre; Tammiksaar, Erki

    2013-01-01

    Historical perspectives on fisheries and related human behaviour provide valuable information on fishery resources and their exploitation, helping to more appropriately set management targets and determine relevant reference levels. In this study we analyse historical fisheries and fish trade at the north-eastern Baltic Sea coast in the late 17th century. Local consumption and export together amounted to the annual removal of about 200 tonnes of fish from the nearby sea and freshwater bodies. The fishery was very diverse and exploited altogether one cyclostome and 17 fish species with over 90% of the catch being consumed locally. The exported fish consisted almost entirely of high-valued species with Stockholm (Sweden) being the most important export destination. Due to rich political history and natural features of the region, we suggest that the documented evidence of this small-scale fishery should be considered as the first quantitative summary of exploitation of aquatic living resources in the region and can provide a background for future analyses. PMID:23861914

  16. Quantification of the early small-scale fishery in the north-eastern Baltic Sea in the late 17th century.

    PubMed

    Verliin, Aare; Ojaveer, Henn; Kaju, Katre; Tammiksaar, Erki

    2013-01-01

    Historical perspectives on fisheries and related human behaviour provide valuable information on fishery resources and their exploitation, helping to more appropriately set management targets and determine relevant reference levels. In this study we analyse historical fisheries and fish trade at the north-eastern Baltic Sea coast in the late 17th century. Local consumption and export together amounted to the annual removal of about 200 tonnes of fish from the nearby sea and freshwater bodies. The fishery was very diverse and exploited altogether one cyclostome and 17 fish species with over 90% of the catch being consumed locally. The exported fish consisted almost entirely of high-valued species with Stockholm (Sweden) being the most important export destination. Due to rich political history and natural features of the region, we suggest that the documented evidence of this small-scale fishery should be considered as the first quantitative summary of exploitation of aquatic living resources in the region and can provide a background for future analyses.

  17. Apple Seeks To Regain Its Stature in World of Academic Computing.

    ERIC Educational Resources Information Center

    Young, Jeffrey R.; Blumenstyk, Goldie

    1998-01-01

    Managers of Apple Computer, the company that pioneered campus personal computing and later lost most of its share of the market, are again focusing energies on academic buyers. Campus technology officials, even those fond of Apples, are greeting the company's efforts with caution. Some feel it may be too late for Apple to regain a significant…

  18. The World through Glass: Developing Novel Methods with Wearable Computing for Urban Videographic Research

    ERIC Educational Resources Information Center

    Paterson, Mark; Glass, Michael R.

    2015-01-01

    Google Glass was deployed in an Urban Studies field course to gather videographic data for team-based student research projects. We evaluate the potential for wearable computing technology such as Glass, in combination with other mobile computing devices, to enhance reflexive research skills, and videography in particular, during field research.…

  19. Apple Seeks To Regain Its Stature in World of Academic Computing.

    ERIC Educational Resources Information Center

    Young, Jeffrey R.; Blumenstyk, Goldie

    1998-01-01

    Managers of Apple Computer, the company that pioneered campus personal computing and later lost most of its share of the market, are again focusing energies on academic buyers. Campus technology officials, even those fond of Apples, are greeting the company's efforts with caution. Some feel it may be too late for Apple to regain a significant…

  20. The World through Glass: Developing Novel Methods with Wearable Computing for Urban Videographic Research

    ERIC Educational Resources Information Center

    Paterson, Mark; Glass, Michael R.

    2015-01-01

    Google Glass was deployed in an Urban Studies field course to gather videographic data for team-based student research projects. We evaluate the potential for wearable computing technology such as Glass, in combination with other mobile computing devices, to enhance reflexive research skills, and videography in particular, during field research.…

  1. The Shaping of the Lutheran Teaching Profession and Lutheran Families of Teachers in the 16th and 17th Centuries (Illustrated by the Example of the Trencín, Liptov and Orava Superintendency)

    ERIC Educational Resources Information Center

    Bernát, Libor

    2012-01-01

    The article deals with changes in the status of teachers and the shaping of Lutheran families of teachers in the 16th and 17th centuries in the Trencín, Liptov and Orava districts of the superintendency. It describes the formation of the families and their background.

  2. The Teaching of Russian Language and Literature in Europe = L'enseignement de la langue et de la litterature russes en Europe = Prepodavanie russkogo yaeyka i literatury v Europe. Proceedings of the AIMAV Seminar (17th, Brussels, Belgium, 1986).

    ERIC Educational Resources Information Center

    Blankoff, Jean, Ed.; And Others

    Papers from the Proceedings of the 17th meeting of the AIMAV (Association internationale pour le developpement de la communication interculturelle) are collected in this volume. Conference papers appear either in English, in French, or in Russian. For purposes of this abstract, all titles below have been translated into English. The…

  3. Polyhedral Sculpture: The Path from Computational Artifact to Real-World Mathematical Object.

    ERIC Educational Resources Information Center

    Eisenberg, Michael; Nishioka, Ann

    Mathematics educators often despair at math's austere, "abstract" reputation. This paper describes recent work in developing an application named "HyperGami," which is designed to integrate both the abstract and"real-world" aspects of mathematics by allowing children to design and construct polyhedral models and…

  4. The Tragedy of Logos: Networked Computer Classrooms and Contact with Strange Discourse Worlds.

    ERIC Educational Resources Information Center

    Weeden, Scott R.

    According to author David Roochnik, the "tragedy of logos" refers to the condition of having a "logos" (meaning a view of the rational structure of the world) and colliding with its limits and limitations. The tragedy of logos arises when some event or experience shows that things are otherwise, because tragedy entails the…

  5. [Louis XIV's Ginseng: Shaping of Knowledge on an Herbal Medicine in the Late 17th and the Early 18th Century France].

    PubMed

    Lee, Hye-Min

    2016-04-01

    This article aims to investigate the shaping of knowledge and discourse on ginseng, especially among physicians and botanists, since its introduction to France from the 17th century until the early 18th century. In France, knowledge on herbal medicine, including that of ginseng, was shaped under the influence of the modern state's policy and institution: mercantilism and the Académie royale des sciences. The knowledge of herbal medicine developed as an important part of the mercantilist policy supported systematically by the Académie. The East Asian ginseng, renowned as a panacea, was first introduced into France in the 17th century, initially in a roundabout way through transportation and English and Dutch publications of travel tales from various foreign countries. The publication activity was mainly conducted by Thévenot company with the intention to meet the needs of French mercantilism promoted by Colbert. It also implied interests on medicine in order to bolster the people's health. The Thévenot company's activity thus offered vital information on plants and herbs abroad, one of which was ginseng. Furthermore, with Louis XIV's dispatching of the Jesuit missionaries to East Asia, the Frenchmen were able to directly gather information on ginseng. These information became a basis for research of the Académie. In the Académie, founded in 1666 by Colbert, the king's physicians and botanists systematically and collectively studied on exotic plants and medical herbs including ginseng. They were also key figures of the Jardin du Roi. These institutions bore a striking contrast to the faculty of medicine at the University of Paris which has been a center of the traditional Galenic medicine. The research of the Académie on ginseng was greatly advanced, owing much to the reports and samples sent from China and Canada by Jartoux, Sarrazin, and Lapitau. From the early 18th century, the conservative attitude of the University of Paris, which was a stronghold of

  6. Medical computing over the World Wide Web: use of forms and CGI scripts for constructing medical algorithm Web pages.

    PubMed

    Doyle, D J; Jarvis, B A; Ruskin, K J; Engel, T P

    1997-01-01

    The development of the World Wide Web has led to an explosion of educational and clinical resources available via the Internet with minimal effort or special training. However, most of these Web pages contain only static information; few offer dynamic information shaped around clinical or laboratory test findings. In this report we show how this goal can be achieved with the design and construction of Medical Algorithm Web Pages (MAWP). Specifically, using Internet technologies known as forms and CGI scripts we demonstrate how one can implement medical algorithms remotely over the Internet's World Wide Web. To use a MAWP, one enters the URL for the site and then enters information according to the instructions presented there, usually by entering numbers and other information into fields displayed on screen. When all the data is entered, the user clicks on the SUBMIT icon, resulting in a new Web page being constructed "on-the-fly" containing diagnostic calculations and other information pertinent to the patient's clinical management. Four sample applications are presented in detail to illustrate the concept of a Medical Algorithm Web page: Computation of the alveolar-arterial oxygen tension difference using the alveolar gas equation; Computation of renal creatinine clearance; drug infusion calculation (micrograms/kilogram/minute); Computation of the renal failure index.

  7. Stellar Occultations by Large TNOs on 2012: The February 3rd by (208996) 2003 AZ84, and the February 17th by (50000) Quaoar

    NASA Astrophysics Data System (ADS)

    Braga Ribas, Felipe; Sicardy, B.; Ortiz, J. L.; Duffard, R.; Camargo, J. I. B.; Lecacheux, J.; Colas, F.; Vachier, F.; Tanga, P.; Sposetti, S.; Brosch, N.; Kaspi, S.; Manulis, I.; Baug, T.; Chandrasekhar, T.; Ganesh, S.; Jain, J.; Mohan, V.; Sharma, A.; Garcia-Lozano, R.; Klotz, A.; Frappa, E.; Jehin, E.; Assafin, M.; Vieira Martins, R.; Behrend, R.; Roques, F.; Widemann, T.; Morales, N.; Thirouin, A.; Mahasena, P.; Benkhaldoun, Z.; Daassou, A.; Rinner, C.; Ofek, E. O.

    2012-10-01

    On February 2012, two stellar occultation's by large Trans-neptunian Objects (TNO's) were observed by our group. On the 3rd, an event by (208996) 2003 AZ84 was recorded from Mont Abu Observatory and IUCAA Girawali Observatory in India and from Weizmann Observatory in Israel. On the 17th, a stellar occultation by (50000) Quaoar was observed from south France and Switzerland. Both occultations are the second observed by our group for each object, and will be used to improve the results obtained on the previous events. The occultation by 2003 AZ84 is the first multi-chord event recorded for this object. From the single chord event on January 8th 2011, Braga-Ribas et al. 2011 obtained a lower limit of 573 +/- 21 km. From the 2012 occultation the longest chord has a size of 662 +/- 50 km. The other chords will permit to determine the size and shape of the TNO, and derive other physical parameters, such as the geometric albedo. The Quaoar occultation was observed from south of France (Observatoire de la Côte d'Azur, TAROT telescope and Valensole) and from Gnosca, Switzerland. Unfortunately, all three sites in France are almost at the same Quaoar's latitude, so in practice, we have two chords that can be used to fit Quaoar's limb. The resulting fit will be compared with the results obtained by Braga-Ribas et al. 2011. Braga-Ribas F., Sicardy B., et al. 2011, EPSC-DPS2011, 1060.Ribas F., Sicardy B., et al. 2011, EPSC-DPS2011, 1060.

  8. PREFACE: Papers from the 17th European Conference on Atomic and Molecular Physics of Ionized Gases (Constanta, Romania, 1 5 September 2004)

    NASA Astrophysics Data System (ADS)

    Ciupina, V.; Musa, G.; Vladoiu, R.

    2005-05-01

    The 17th European Conference on Atomic and Molecular Physics of Ionized Gases (ESCAMPIG-17) was held in Constanta, Romania, on 1-5 September 2004. ESCAMPIG is an important biennial European conference at which useful exchanges of ideas and discussion of new achievements in low temperature plasma physics take place. The meeting was held in the ambient location of Constanta, Romania, which provided the perfect location to encourage interaction between the related research communities attending the conference. The local organizers, as well as the plasma scientists of Romania, were all very much honoured that Constanta was selected by the International Scientific Committee as the location for ESCAMPIG-17. The conference was the second largest plasma physics conference ever to take place in Romania, second only to the ICPIG conference of 1969 in Bucharest—a huge conference with four parallel sections and simultaneous translation in four languages (English, German, French and Russian) in all four parallel sections. In contrast, ESCAMPIG-17 maintained the founding ideals and held single sessions only to encourage and strengthen the relationships between research communities. During ESCAMPIG-17 we had the opportunity to attend and hear excellent invited lectures presenting outstanding new results in plasma physics. A selection of those invited lectures from ESCAMPIG-17 is published in this issue of Plasma Sources Science and Technology. We would like to take this opportunity to express our thanks to all the invited lecturers and also to all the participants who attended ESCAMPIG-17. The Local Organizing Committee would particularly like to thank all the International Scientific Committee members. Special thanks are due to Professor Gerrit Kroesen and Professor Nader Sadeghi for their valuable and continuous support in solving our problems, no matter how complicated they were.

  9. Gluten-free diet does not influence the occurrence and the Th1/Th17-Th2 nature of immune-mediated diseases in patients with coeliac disease.

    PubMed

    Imperatore, Nicola; Rispo, Antonio; Capone, Pietro; Donetto, Sara; De Palma, Giovanni Domenico; Gerbino, Nicolò; Rea, Matilde; Caporaso, Nicola; Tortora, Raffaella

    2016-07-01

    Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). To evaluate: (1) the prevalence of IMD at the time of and after CD diagnosis; (2) a possible change in immune response to gluten free diet (GFD); (3) the potential role of GFD in reducing and/or preventing IMD in CD. Prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p=0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant "switch" from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p<0.01; OR 1.9). The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  10. Social differences in oral health: Dental status of individuals buried in and around Trakai Church in Lithuania (16th-17th c.c.).

    PubMed

    Miliauskienė, Žydrūnė; Jankauskas, Rimantas

    2015-01-01

    The evaluation of social differences in dental health is based on the assumption that individuals belonging to a higher social class consumed a different diet than a common people. The aim of our study was to analyse and compare dental health of 16(th) - 17(th) c. individuals, buried inside and around the Roman Catholic Church in Trakai (Lithuania). All material (189 adult individuals) was divided in two samples of a presumably different social status: the Churchyard (ordinary townsmen) and the Presbytery (elite). Dental status analysis included that of tooth loss, tooth wear, caries, abscesses and calculus. Results revealed higher prevalence of dental disease in the Churchyard sample compared to the Presbytery. Individuals buried around the church had statistically higher prevalence of caries, antemortem tooth loss and abscesses compared to those who were buried inside the church. The Churchyard sample was also characterised by a higher increase in severity of caries with age, and a more rapid tooth wear. Differences in dental health between the samples the most probably reflect different dietary habits of people from different social groups: poor quality carbohydrate based diet of laymen buried in the churchyard and more varied diet with proteins and of a better quality of local elite, buried inside the church. Substantial sex differences in dental health were found only in the Churchyard sample: males had statistically higher prevalence of abscesses and calculus, while females had higher prevalence of caries and AMTL (antemortem tooth loss). Females were also characterised by a higher increase in the number of dental decay and tooth loss with age and had higher prevalence of gross caries, which indicates a more rapid progression of the disease. Worse dental health of females could be a result of culturally based dietary differences between females (more carbohydrates) and males (more proteins) and different physiological demands (hormonal fluctuations and

  11. PREFACE: 17th International School on Condensed Matter Physics (ISCMP): Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications

    NASA Astrophysics Data System (ADS)

    Dimova-Malinovska, Doriana; Nesheva, Diana; Pecheva, Emilia; Petrov, Alexander G.; Primatarowa, Marina T.

    2012-12-01

    We are pleased to introduce the Proceedings of the 17th International School on Condensed Matter Physics: Open Problems in Condensed Matter Physics, Biomedical Physics and their Applications, organized by the Institute of Solid State Physics of the Bulgarian Academy of Sciences. The Chairman of the School was Professor Alexander G Petrov. Like prior events, the School took place in the beautiful Black Sea resort of Saints Constantine and Helena near Varna, going back to the refurbished facilities of the Panorama hotel. Participants from 17 different countries delivered 31 invited lecturers and 78 posters, contributing through three sessions of poster presentations. Papers submitted to the Proceedings were refereed according to the high standards of the Journal of Physics: Conference Series and the accepted papers illustrate the diversity and the high level of the contributions. Not least significant factor for the success of the 17 ISCMP was the social program, both the organized events (Welcome and Farewell Parties) and the variety of pleasant local restaurants and beaches. Visits to the Archaeological Museum (rich in valuable gold treasures of the ancient Thracian culture) and to the famous rock monastery Aladja were organized for the participants from the Varna Municipality. These Proceedings are published for the second time by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for supporting this idea. The Committee decided that the next event will take place again in Saints Constantine and Helena, 1-5 September 2014. It will be entitled: Challenges of the Nanoscale Science: Theory, Materials and Applications. Doriana Dimova-Malinovska, Diana Nesheva, Emilia Pecheva, Alexander G Petrov and Marina T Primatarowa Editors

  12. Use of a virtual world computer environment for international distance education: lessons from a pilot project using Second Life

    PubMed Central

    2014-01-01

    Virtual worlds (VWs), in which participants navigate as avatars through three-dimensional, computer-generated, realistic-looking environments, are emerging as important new technologies for distance health education. However, there is relatively little documented experience using VWs for international healthcare training. The Geneva Foundation for Medical Education and Research (GFMER) conducted a VW training for healthcare professionals enrolled in a GFMER training course. This paper describes the development, delivery, and results of a pilot project undertaken to explore the potential of VWs as an environment for distance healthcare education for an international audience that has generally limited access to conventionally delivered education. PMID:24555833

  13. A Future of Reversals: Dyslexic Talents in a World of Computer Visualization.

    ERIC Educational Resources Information Center

    West, Thomas G.

    1992-01-01

    This paper proposes that those traits which handicap visually oriented dyslexics in a verbally oriented educational system may confer advantages in new fields which rely on visual methods of analysis, especially those in computer applications. It is suggested that such traits also characterized Albert Einstein, Michael Faraday, James Maxwell, and…

  14. The future of voice-processing technology in the world of computers and communications.

    PubMed Central

    Kato, Y

    1995-01-01

    This talk, which was the keynote address of the NAS Colloquium on Human-Machine Communication by Voice, discusses the past, present, and future of human-machine communications, especially speech recognition and speech synthesis. Progress in these technologies is reviewed in the context of the general progress in computer and communications technologies. PMID:7479726

  15. The future of voice-processing technology in the world of computers and communications.

    PubMed

    Kato, Y

    1995-10-24

    This talk, which was the keynote address of the NAS Colloquium on Human-Machine Communication by Voice, discusses the past, present, and future of human-machine communications, especially speech recognition and speech synthesis. Progress in these technologies is reviewed in the context of the general progress in computer and communications technologies.

  16. Computer Assisted Comprehension of Distant Worlds: Understanding Hunger Dynamics in Africa.

    ERIC Educational Resources Information Center

    Moseley, William G.

    2001-01-01

    Describes a computer program called RiskMap. Explains that after completing an assignment on rural economics and hunger dynamics in Africa, students showed an increased level of understanding and felt that using RiskMap was helpful in learning the material. Includes references. (DAJ)

  17. A Future of Reversals: Dyslexic Talents in a World of Computer Visualization.

    ERIC Educational Resources Information Center

    West, Thomas G.

    1992-01-01

    This paper proposes that those traits which handicap visually oriented dyslexics in a verbally oriented educational system may confer advantages in new fields which rely on visual methods of analysis, especially those in computer applications. It is suggested that such traits also characterized Albert Einstein, Michael Faraday, James Maxwell, and…

  18. Taking Interpersonal Communication out of the Classroom into the World of Computer Technology.

    ERIC Educational Resources Information Center

    Gantt, Vernon W.

    The emergence of the information society introduces the academic community to the most significant revolution since the invention of the printing press. The growing use of computers can lead to a depreciation of self-worth. Since the machine can handle complex logical applications with considerably more speed and accuracy than most people, many…

  19. Millisecond precision psychological research in a world of commodity computers: new hardware, new problems?

    PubMed

    Plant, Richard R; Turner, Garry

    2009-08-01

    Since the publication of Plant, Hammond, and Turner (2004), which highlighted a pressing need for researchers to pay more attention to sources of error in computer-based experiments, the landscape has undoubtedly changed, but not necessarily for the better. Readily available hardware has improved in terms of raw speed; multi core processors abound; graphics cards now have hundreds of megabytes of RAM; main memory is measured in gigabytes; drive space is measured in terabytes; ever larger thin film transistor displays capable of single-digit response times, together with newer Digital Light Processing multimedia projectors, enable much greater graphic complexity; and new 64-bit operating systems, such as Microsoft Vista, are now commonplace. However, have millisecond-accurate presentation and response timing improved, and will they ever be available in commodity computers and peripherals? In the present article, we used a Black Box ToolKit to measure the variability in timing characteristics of hardware used commonly in psychological research.

  20. The world problem: on the computability of the topology of 4-manifolds

    NASA Technical Reports Server (NTRS)

    vanMeter, J. R.

    2005-01-01

    Topological classification of the 4-manifolds bridges computation theory and physics. A proof of the undecidability of the homeomorphy problem for 4-manifolds is outlined here in a clarifying way. It is shown that an arbitrary Turing machine with an arbitrary input can be encoded into the topology of a 4-manifold, such that the 4-manifold is homeomorphic to a certain other 4-manifold if and only if the corresponding Turing machine halts on the associated input. Physical implications are briefly discussed.

  1. MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells.

    PubMed

    Ma, L; Xue, H-B; Wang, F; Shu, C-M; Zhang, J-H

    2015-07-01

    Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related orphan receptor (ROR)γt, interleukin (IL)-17 and suppressor of cytokine signalling-1 (SOCS1) in peripheral CD4(+) T cells, plasma and skin specimens were detected and compared in AD patients and healthy subjects. A miR-155 mimic and an inhibitor were transfected separately into AD CD4(+) T cells to confirm the in-vivo data. The Th17 cell percentage, miR-155 expression, RORγt mRNA expression, IL-17 mRNA expression and plasma concentration were increased significantly in AD patients compared with healthy subjects. Conversely, SOCS1 mRNA expression and plasma concentration were decreased significantly. Similar results were detected in cultured CD4(+) T cells transfected with the miR-155 mimic compared with a miR-155 inhibitor or a negative control. Additionally, there was a sequential decrease in miR-155 expression, as well as RORγt and IL-17 mRNA expression, but an increase in SOCS1 mRNA expression, from AD lesional skin and perilesional skin to normal skin. Positive correlations were found between miR-155 expression and AD severity, Th17 cell percentage, RORγt mRNA expression and IL-17 mRNA expression and plasma concentration, while negative correlations were observed between miR-155 expression and SOCS1 mRNA expression and plasma concentration in AD peripheral circulation and skin lesions. In conclusion, miR-155 is over-expressed and may be involved in AD pathogenesis by modulating the differentiation and function of Th17 cells.

  2. Paleoclimate Reconstruction during the 17th to 18th Century Using Fossil Coral Tsunami Boulders from Ishigaki Island, the Ryukyus, Japan

    NASA Astrophysics Data System (ADS)

    Tsuzuki, K.; Yokoyama, Y.; Seki, A.; Kawakubo, Y.; Araoka, D.; Suzuki, A.

    2014-12-01

    Resolution Inductively Coupled Plasma Mass Spectrometry) to reconstruct paleo SST during LIA (Kawakubo et al., 2014). LA-HR-ICPMS enables us to measure the long coral core rapidly. Our result shows SST variation in 17th-18th century in this area and SST declined in around 1700. This result reveals the response of Little Ice Age in the northwestern Pacific.

  3. Reconstructing hydroclimatic variability of the Bermejo River (Subtropical Andes of Argentina-Bolivia) through Archival Documents - 17th to 20th centuries

    NASA Astrophysics Data System (ADS)

    Del Rosario Prieto, M.; Cueto, C.

    2009-09-01

    The purpose of this paper is to use climatic history for contributing to the general objectives of the IAI -CRN II-047 Project. It will reconstruct, from archival documents, the hydroclimatic variability occurring in the high basin of the Bermejo River during the last centuries and its effects on the floods and swellings in the middle basin. The Río Bermejo in the Southern Andes, is a binational (Argentina-Bolivia) river that contributes the largest proportion of the sediment load to the La Plata basin. Its headwaters are in the Subtropical Andes, near Tarija, Bolivia (22?00'14"S, 64?57'38"W). The main headwater tributaries are the Río Grande de Tarija, in Bolivia and the Iruya and San Francisco Rivers in Argentina. When the river abandons the mountain and turns eastwards (Gran Chaco), it acquires the characteristics of typical lowland rivers, widens its course, and occupies a large, low sedimentary plain with vast floodland areas. Quite often during very high sediment discharge the main river avulses and changes its course, creating big alluvial plains that are occupied for many years. Administrative documents from the colonial and republican periods have provided useful information to reconstruct climate and hydrology of the region. Documents from the Archivo General de Indias in Seville, Archivo Nacional de Bolivia and Archivo General de la Nación (Argentina) have been used to identify extreme floods and swellings in the high and middle-basin of the Rio Bermejo from the 17th century to the first decades of the 20th century. Old maps of the region, reports from annals, chronicles, priests' and travelers' descriptions were also used. Diaries written by the military, explorers and government officials in charge of discovering and taking possession of the territory also provide important sources of information. The archival documents show abrupt hydrological changes in response to the climatic fluctuations in the headwaters region. These records document

  4. Community as client: environmental issues in the real world. A SimCity computer simulation.

    PubMed

    Bareford, C G

    2001-01-01

    The ability to think critically has become a crucial part of professional practice and education. SimCity, a popular computer simulation game, provides an opportunity to practice community assessment and interventions using a systems approach. SimCity is an interactive computer simulation game in which the player takes an active part in community planning. SimCity is supported on either a Windows 95/98 or a Macintosh platform and is available on CD-ROM at retail stores or at www.simcity.com. Students complete a tutorial and then apply a selected scenario in SimCity. Scenarios consist of hypothetical communities that have varying types and degrees of environmental problems, e.g., traffic, crime, nuclear meltdown, flooding, fire, and earthquakes. In problem solving with the simulated scenarios, students (a) identify systems and subsystems within the community that are critical factors impacting the environmental health of the community, (b) create changes in the systems and subsystems in an effort to solve the environmental health problem, and (c) evaluate the effectiveness of interventions based on the game score, demographic and fiscal data, and amount of community support. Because the consequences of planned intervention are part of the simulation, nursing students are able to develop critical-thinking skills. The simulation provides essential content in community planning in an interesting and interactive format.

  5. Electronic Transfer of Information and Its Impact on Aerospace and Defence Research and Development. Proceedings of the Technical Information Panel Specialists’ Meeting Held in Brussels, Belgium on 17th-19th October 1989 Abstracts.

    DTIC Science & Technology

    1990-01-01

    INTRODUCTION 1 SUMMARIES OF PAPERS AND DISCUSSIONS COMMENTS ON TECHNOLOGIES 13 RECOMMENDATIONS 15 p fl ton for DTIK TAs Ummnonn e a hJatirtca~io S...was heid from 17th- 19th October 1989 in Brussels, Belgium; and comments on the state of the art of the technologies presented, discusses their possible...introduction into scientific and technical organisations, and provides recommendations on the use of technologies with emphasis on the aerospace and

  6. [Spanish authors in the ideal library of G. Naudé (1627): a European view of the Spanish culture and science at the beginning of the 17th century].

    PubMed

    Muñoz, Evaristo álvarez

    2010-01-01

    This article aims to analyze a European view of the 17th century Spanish culture. Naudé's "Advis pour dresser une bibliothèque" (1627) - translated twice into English: "Instructions concerning erecting of a library" (1661) and "Advice on establishing a library" (1950) - represents a wide set of bibliographic recommendations that constitute, among many other things, an excellent observatory of the Spanish culture in such a delicate time.

  7. Computed tomographic evidence of atherosclerosis in the mummified remains of humans from around the world.

    PubMed

    Thompson, Randall C; Allam, Adel H; Zink, Albert; Wann, L Samuel; Lombardi, Guido P; Cox, Samantha L; Frohlich, Bruno; Sutherland, M Linda; Sutherland, James D; Frohlich, Thomas C; King, Samantha I; Miyamoto, Michael I; Monge, Janet M; Valladolid, Clide M; El-Halim Nur El-Din, Abd; Narula, Jagat; Thompson, Adam M; Finch, Caleb E; Thomas, Gregory S

    2014-06-01

    Although atherosclerosis is widely thought to be a disease of modernity, computed tomographic evidence of atherosclerosis has been found in the bodies of a large number of mummies. This article reviews the findings of atherosclerotic calcifications in the remains of ancient people-humans who lived across a very wide span of human history and over most of the inhabited globe. These people had a wide range of diets and lifestyles and traditional modern risk factors do not thoroughly explain the presence and easy detectability of this disease. Nontraditional risk factors such as the inhalation of cooking fire smoke and chronic infection or inflammation might have been important atherogenic factors in ancient times. Study of the genetic and environmental risk factors for atherosclerosis in ancient people may offer insights into this common modern disease.

  8. A two-class brain computer interface to freely navigate through virtual worlds.

    PubMed

    Ron-Angevin, Ricardo; Díaz-Estrella, Antonio; Velasco-Alvarez, Francisco

    2009-06-01

    A brain computer interface that enables navigation through a virtual environment (VE) using four different navigation commands (turn right, turn left, move forward and move back) is presented. A graphical interface allows subjects to select a specific command. In this interface, the different navigation commands are surrounding a circle. A bar in the center of the circle is continuously rotating. The subject controls, by only two mental tasks, the bar extension to reach the chosen command. In this study, after an initial training based on three sessions, 8 out of 15 naive subjects were able to navigate through the VE discriminating between imagination of right-hand movements and relaxed state. All subjects (except one) improved their performance in each run and a mean error rate of 23.75% was obtained.

  9. Modelling skin disease: lessons from the worlds of mathematics, physics and computer science.

    PubMed

    Gilmore, Stephen

    2005-05-01

    Theoretical biology is a field that attempts to understand the complex phenomena of life in terms of mathematical and physical principles. Likewise, theoretical medicine employs mathematical arguments and models as a methodology in approaching the complexities of human disease. Naturally, these concepts can be applied to dermatology. There are many possible methods available in the theoretical investigation of skin disease. A number of examples are presented briefly. These include the mathematical modelling of pattern formation in congenital naevi and erythema gyratum repens, an information-theoretic approach to the analysis of genetic networks in autoimmunity, and computer simulations of early melanoma growth. To conclude, an analogy is drawn between the behaviour of well-known physical processes, such as earthquakes, and the spatio-temporal evolution of skin disease. Creating models in skin disease can lead to predictions that can be investigated experimentally or by observation and offer the prospect of unexpected or important insights into pathogenesis.

  10. The Fate of the World is in your hands: computer gaming for multi-faceted climate change education

    NASA Astrophysics Data System (ADS)

    Bedford, D. P.

    2015-12-01

    Climate change is a multi-faceted (or 'wicked') problem. True climate literacy therefore requires understanding not only the workings of the climate system, but also the current and potential future impacts of climate change and sea level rise on individuals, communities and countries around the world, as noted in the US Global Change Research Program's (2009) Climate Literacy: The Essential Principles of Climate Sciences. The asymmetric nature of climate change impacts, whereby the world's poorest countries have done the least to cause the problem but will suffer disproportionate consequences, has also been widely noted. Education in climate literacy therefore requires an element of ethics in addition to physical and social sciences. As if addressing these multiple aspects of climate change were not challenging enough, polling data has repeatedly shown that many members of the public tend to see climate change as a far away problem affecting people remote from them at a point in the future, but not themselves. This perspective is likely shared by many students. Computer gaming provides a possible solution to the combined problems of, on the one hand, addressing the multi-faceted nature of climate change, and, on the other hand, making the issue real to students. Fate of the World, a game produced by the company Red Redemption, has been used on several occasions in a small (20-30 students) introductory level general education course on global warming at Weber State University. Players are required to balance difficult decisions about energy investment while managing regional political disputes and attempting to maintain minimum levels of development in the world's poorer countries. By providing a realistic "total immersion" experience, the game has the potential to make climate change issues more immediate to players, and presents them with the ethical dilemmas inherent in climate change. This presentation reports on the use of Fate of the World in an educational

  11. Envisioning a Future of Computational Geoscience in a Data Rich Semantic World

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Elag, M.; Jiang, P.; Marini, L.

    2015-12-01

    Advances in observational systems and reduction in their cost are allowing us to explore, monitor, and digitally represent our environment in unprecedented details and over large areas. Low cost in situ sensors, unmanned autonomous vehicles, imaging technologies, and other new observational approaches along with airborne and space borne systems are allowing us to measure nearly everything, almost everywhere, and at almost all the time. Under the aegis of observatories they are enabling an integrated view across space and time scales ranging from storms to seasons to years and, in some cases, decades. Rapid increase in the convergence of computational, communication and information systems and their inter-operability through advances in technologies such as semantic web can provide opportunities to further facilitate fusion and synthesis of heterogeneous measurements with knowledge systems. This integration can enable us to break disciplinary boundaries and bring sensor data directly to desktop or handheld devices. We describe CyberInfrastructure effort that is being developed through projects such as Earthcube Geosemantics (http://geosemantics.hydrocomplexity.net), (SEAD (http://sead-data.net/), and Browndog (http://browndog.ncsa.illinois.edu/)s o that data across all of earth science can be easily shared and integrated with models. This also includes efforts to enable models to become interoperable among themselves and with data using technologies that enable human-out-of-the-loop integration. Through such technologies our ability to use real time information for decision-making and scientific investigations will increase multifold. The data goes through a sequence of steps, often iterative, from collection to long-term preservation. Similarly the scientific investigation and associated outcomes are composed of a number of iterative steps from problem identification to solutions. However, the integration between these two pathways is rather limited. We describe

  12. Conformer Hunting: An Open-Ended Computational Chemistry Exercise That Expresses Real-World Complexity and Student Forethought

    NASA Astrophysics Data System (ADS)

    Lipkowitz, Kenny B.; Robertson, Daniel

    2000-02-01

    A computational chemistry project suitable for both graduate and undergraduate classes has been developed, tested, and implemented successfully over the course of 10 years. In this project we ask students the following simple question: "Which conformer searching strategy in Spartan is the best?" To answer this question the students need to develop a working definition of what "best" means within the context of the project, design their own experiments that can address that question most suitably, carry out the calculations to derive a compelling answer, and then write their results in the form of a research paper. In addition to teaching students about potential energy surfaces, molecular modeling techniques, and stereochemistry, the pedagogical advantages of this computational chemistry exercise compared to others published in this Journal are that it (i) requires a significant amount of student forethought in addition to afterthought by forcing students to design their own experiments, (ii) demonstrates real-world levels of complexity by using molecules having multiple rotatable bonds, (iii) allows for student creativity that is missing in most other published exercises, (iv) focuses on writing in the curriculum.

  13. Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses

    PubMed Central

    Kerr, Scott A.; Jackson, Eleisha L.; Lungu, Oana I.; Meyer, Austin G.; Demogines, Ann; Ellington, Andrew D.; Georgiou, George

    2015-01-01

    ABSTRACT Animal viruses frequently cause zoonotic disease in humans. As these viruses are highly diverse, evaluating the threat that they pose remains a major challenge, and efficient approaches are needed to rapidly predict virus-host compatibility. Here, we develop a combined computational and experimental approach to assess the compatibility of New World arenaviruses, endemic in rodents, with the host TfR1 entry receptors of different potential new host species. Using signatures of positive selection, we identify a small motif on rodent TfR1 that conveys species specificity to the entry of viruses into cells. However, we show that mutations in this region affect the entry of each arenavirus differently. For example, a human single nucleotide polymorphism (SNP) in this region, L212V, makes human TfR1 a weaker receptor for one arenavirus, Machupo virus, but a stronger receptor for two other arenaviruses, Junin and Sabia viruses. Collectively, these findings set the stage for potential evolutionary trade-offs, where natural selection for resistance to one virus may make humans or rodents susceptible to other arenavirus species. Given the complexity of this host-virus interplay, we propose a computational method to predict these interactions, based on homology modeling and computational docking of the virus-receptor protein-protein interaction. We demonstrate the utility of this model for Machupo virus, for which a suitable cocrystal structural template exists. Our model effectively predicts whether the TfR1 receptors of different species will be functional receptors for Machupo virus entry. Approaches such at this could provide a first step toward computationally predicting the “host jumping” potential of a virus into a new host species. IMPORTANCE We demonstrate how evolutionary trade-offs may exist in the dynamic evolutionary interplay between viruses and their hosts, where natural selection for resistance to one virus could make humans or rodents susceptible

  14. Registration and Scheduling at NIU (Implementing Commercial Software at a Large University.) College and University Machine Records Annual Conference (17th, Columbus, Ohio, May 1972).

    ERIC Educational Resources Information Center

    Karabinus, Robert A.; Boris, Richard

    This document describes the development and implementation of a computer based registration and scheduling information system at Northern Illinois University. Because of personnel shortages, the University sought and received help from commercial computer firms. Implementation of scheduling, registration, and billing systems was accomplished in a…

  15. Scandinavian Conference of Linguistics, Volumes I [and] II (17th, Nyborg, Denmark, August 20-22, 1998). Odense Working Papers in Language and Communication.

    ERIC Educational Resources Information Center

    Lindberg, Carl-Erik, Ed.; Lund, Steffen Nordahl, Ed.

    The two volumes of these working papers include articles by linguists from Scandinavia and other parts of the world. Under the heading, "The Use of IT in Grammatical Analysis/Parsing" are five articles: "Creating Inflecting Electronic Thesauri"; "Tagging Speech Data--Constraint Grammar Analysis of Spoken Portuguese";…

  16. Scandinavian Conference of Linguistics, Volumes I [and] II (17th, Nyborg, Denmark, August 20-22, 1998). Odense Working Papers in Language and Communication.

    ERIC Educational Resources Information Center

    Lindberg, Carl-Erik, Ed.; Lund, Steffen Nordahl, Ed.

    The two volumes of these working papers include articles by linguists from Scandinavia and other parts of the world. Under the heading, "The Use of IT in Grammatical Analysis/Parsing" are five articles: "Creating Inflecting Electronic Thesauri"; "Tagging Speech Data--Constraint Grammar Analysis of Spoken Portuguese";…

  17. [Pierre and Philippe Ranquet, father and son, apothecaries in rue Saint-Honoré, Paris in the 17th century, suppliers to the duchess of Vendôme].

    PubMed

    Warolin, Christian

    2008-05-01

    This research concerns two apothecaries in Paris living in the rue Saint-Honoré in the 17th century. Pierre Ranquet, father of Philippe Ranquet, was apothecary to the Duchess of Mercoeur and her daughter the Duchess of Vendôme, members of the nobility. Philippe was a member of the community of apothecary-grocers of Paris, keeping shop and dispensing drugs to a large clientele in the Saint-Honoré district, including many noblemen and women. He became supplier to the Duchess of Vendôme following the death of his father in 1652.

  18. Quantum computers and reality: Deutsch's anti-positivist campaign for explanations-in-general, apart from his Many Worlds Interpretation.

    NASA Astrophysics Data System (ADS)

    O'Donnell, Thomas W.

    2002-04-01

    David Deutsch (Oxford University) is known for ``Deutsch's algorithmm"---for going beyond the initial ideas about quantum computing (QC) of Benioff, Bennett and Feynman, to describe a quantum Turing machine, and sparking today's widespread experimental research to actually build one. Deutsch does not accept the standard Copenhagen Interpretation (CI) of quantum mechanics (QM); he supports the Many Worlds Interpretation (MWI) and credits it for his insights. In his book, The Fabric of Reality, and numerous articles and talks, he argues that the the adoption of the MWI is phnecessary for making the advances required for quantum computing. His argues that physicists must resolutely take a ``realistic" viewpoint to its logical conclusions, and, that the MWI is phthe realistic theory. In response to ubiquitous assertions by the majority of physicists that ``both systems give the same numbers," and ``all physics does (or can do) is to predict the outcome of experiments," he argues strenuously for the importance of explanations in quantum physics, and to scientific progress in general. Hence, I argue that there are two, reasonably separable, layers here: (i) opposition to positivist and instrumentalist arguments against the validity and/or value of phany explanation(s) phas such, and (ii) an argument about just what is the correct explanation: the MWI over the CI. While establishing the validity of (i) may possibly undermine CI's spirit, nevertheless (i) can be strongly validated independent from complicatons of an overlap with issues of the interpretation of QM. I develop some simple, historical contradictions regarding point (i), (without passing judgement on Deutsch's MWI or involving the CI). For example, the majority viewpoint identifies its seemingly ``non- philosophical" and non-``methaphysical" mindset as archtypically ``scientific", while seemingly quite unaware of the theoretical difficuties with positivist notions of truth, such as the fact that the foundations

  19. Archaeological remains accounting for the presence and exploitation of the North Atlantic right whale Eubalaena glacialis on the Portuguese Coast (Peniche, West Iberia), 16th to 17th Century.

    PubMed

    Teixeira, António; Venâncio, Rui; Brito, Cristina

    2014-01-01

    The former occurrence of the North Atlantic right whale Eubalaena glacialis on the Portuguese coast may be inferred from the historical range of that species in Europe and in NW Africa. It is generally accepted that it was the main prey of coastal whaling in the Middle Ages and in the pre-modern period, but this assumption still needs firming up based on biological and archaeological evidence. We describe the skeletal remains of right whales excavated at Peniche in 2001-2002, in association with archaeological artefacts. The whale bones were covered by sandy sediments on the old seashore and they have been tentatively dated around the 16th to 17th centuries. This study contributes material evidence to the former occurrence of E. glacialis in Portugal (West Iberia). Some whale bones show unequivocal man-made scars. These are associated to wounds from instruments with a sharp-cutting blade. This evidence for past human interaction may suggest that whaling for that species was active at Peniche around the early 17th century.

  20. Archaeological Remains Accounting for the Presence and Exploitation of the North Atlantic Right Whale Eubalaena glacialis on the Portuguese Coast (Peniche, West Iberia), 16th to 17th Century

    PubMed Central

    Teixeira, António; Venâncio, Rui; Brito, Cristina

    2014-01-01

    The former occurrence of the North Atlantic right whale Eubalaena glacialis on the Portuguese coast may be inferred from the historical range of that species in Europe and in NW Africa. It is generally accepted that it was the main prey of coastal whaling in the Middle Ages and in the pre-modern period, but this assumption still needs firming up based on biological and archaeological evidence. We describe the skeletal remains of right whales excavated at Peniche in 2001–2002, in association with archaeological artefacts. The whale bones were covered by sandy sediments on the old seashore and they have been tentatively dated around the 16th to 17th centuries. This study contributes material evidence to the former occurrence of E. glacialis in Portugal (West Iberia). Some whale bones show unequivocal man-made scars. These are associated to wounds from instruments with a sharp-cutting blade. This evidence for past human interaction may suggest that whaling for that species was active at Peniche around the early 17th century. PMID:24505251

  1. Urban land for a growing city at the banks of a moving river: Vienna's spread into the Danube island Unterer Werd from the late 17th to the beginning of the 20th century.

    PubMed

    Haidvogl, Gertrud; Guthyne-Horvath, Marianna; Gierlinger, Sylvia; Hohensinner, Severin; Sonnlechner, Christoph

    In the relation between urban development and the Viennese Danube different periods can be identified from the late 17th to the early 20th century. These periods were strongly intertwined with both the history of the river and the history of the city. Urban expansion into the floodplains is demonstrated in this paper by investigating the island Unterer Werd, next to the city centre. In the late 17th century the fluvial dynamic still hampered urban development on the island. First measures to stabilise the river banks and to protect buildings from floods were taken soon thereafter, but the majority of practices aimed at mitigating the risks and impacts of the frequent floods: inundation was a part of the arrangement and the main target was to minimise the potential impacts. This practice also prevailed after the 1830s, when urban expansion began to move into the north and northwest of the island and the Danube floodplains were considered an important land resource for the growing city. In connection with new technologies and available means to channelise the river, the relationship between Vienna and the Danube changed fundamentally. Urban development in the riverine landscape gained new momentum. This process was initiated before the Great Danube Regulation from 1870 to 1875 was completed, the rate of growth accelerated after 1875. The last decades of the 19th century mark a turning point in the urban development of Vienna, with expanding urban areas becoming dependent upon a well functioning and maintained flood protection system.

  2. Proceedings of the NASTRAN (Tradename) Users’ Colloquium (17th) Held in San Antonio, Texas on 24-28 April 1989

    DTIC Science & Technology

    1989-03-01

    statistical energy analysis , the finite clement method, and the power flow method. Experimental solutions are the most common in the literature. The authors of...to the added weights and inertias of the transducers attached to an experimental structure. Statistical energy analysis (SEA) is a computational method...Analysis and Diagnosis," Journal of Sound and Vibration, Vol. 115, No. 3, pp. 405-422 (1987). 8. Lyon, R.L., Statistical Energy Analysis of Dynamical Systems

  3. Current topics in shock waves; Proceedings of the International Symposium on Shock Waves and Shock Tubes, 17th, Lehigh University, Bethlehem, PA, July 17-21, 1989

    NASA Astrophysics Data System (ADS)

    Kim, Yong W.

    Various papers on shock waves are presented. The general topics addressed include: shock formation, focusing, and implosion; shock reflection and diffraction; turbulence; laser-produced plasmas and waves; ionization and shock-plasma interaction; chemical kinetics, pyrolysis, and soot formation; experimental facilities, techniques, and applications; ignition of detonation and combustion; particle entrainment and shock propagation through particle suspension; boundary layers and blast simulation; computational methods and numerical simulation.

  4. Current topics in shock waves; Proceedings of the International Symposium on Shock Waves and Shock Tubes, 17th, Lehigh University, Bethlehem, PA, July 17-21, 1989

    SciTech Connect

    Kim, Y.W.

    1990-01-01

    Various papers on shock waves are presented. The general topics addressed include: shock formation, focusing, and implosion; shock reflection and diffraction; turbulence; laser-produced plasmas and waves; ionization and shock-plasma interaction; chemical kinetics, pyrolysis, and soot formation; experimental facilities, techniques, and applications; ignition of detonation and combustion; particle entrainment and shock propagation through particle suspension; boundary layers and blast simulation; computational methods and numerical simulation.

  5. 1985 Nuclear Science Symposium, 32nd, and 1985 Symposium on Nuclear Power Systems, 17th, San Francisco, CA, October 23-25, 1985, Proceedings

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The present conference ranges over topics in high energy physics instrumentation, detectors, nuclear medical applications, health physics and environmental monitoring, reactor instrumentation, nuclear spacecraft instrumentation, the 'Fastbus' data acquisition system, circuits and systems for nuclear research facilities, and the development status of nuclear power systems. Specific attention is given to CCD high precision detectors, a drift chamber preamplifier, a Cerenkov ring imaging detector, novel scintillation glasses and scintillating fibers, a modular multidrift vertex detector, radial wire drift chambers, liquid argon polarimeters, a multianode photomultiplier, the reliability of planar silicon detectors, the design and manufacture of wedge and strip anodes, ultrafast triode photodetectors, photomultiplier tubes, a barium fluoride plastic scintillator, a fine grained neutron hodoscope, the stability of low leakage silicon photodiodes for crystal calorimeters, and X-ray proportional counters. Also considered are positron emission tomography, single photon emission computed tomography, nuclear magnetic resonance imaging, Geiger-Muller detectors, nuclear plant safeguards, a 32-bit Fastbus computer, an advanced light water reactor, and nuclear plant maintenance.

  6. 1985 Nuclear Science Symposium, 32nd, and 1985 Symposium on Nuclear Power Systems, 17th, San Francisco, CA, October 23-25, 1985, Proceedings

    NASA Technical Reports Server (NTRS)

    1986-01-01

    The present conference ranges over topics in high energy physics instrumentation, detectors, nuclear medical applications, health physics and environmental monitoring, reactor instrumentation, nuclear spacecraft instrumentation, the 'Fastbus' data acquisition system, circuits and systems for nuclear research facilities, and the development status of nuclear power systems. Specific attention is given to CCD high precision detectors, a drift chamber preamplifier, a Cerenkov ring imaging detector, novel scintillation glasses and scintillating fibers, a modular multidrift vertex detector, radial wire drift chambers, liquid argon polarimeters, a multianode photomultiplier, the reliability of planar silicon detectors, the design and manufacture of wedge and strip anodes, ultrafast triode photodetectors, photomultiplier tubes, a barium fluoride plastic scintillator, a fine grained neutron hodoscope, the stability of low leakage silicon photodiodes for crystal calorimeters, and X-ray proportional counters. Also considered are positron emission tomography, single photon emission computed tomography, nuclear magnetic resonance imaging, Geiger-Muller detectors, nuclear plant safeguards, a 32-bit Fastbus computer, an advanced light water reactor, and nuclear plant maintenance.

  7. Learning to Love Your Computer: A Fourth Grade Study in the Use of Computers and Their Economic Impact on the World Today.

    ERIC Educational Resources Information Center

    McKeever, Barbara

    An award-winning fourth-grade unit combines computer and economics education by examining the impact of computer usage on various segments of the economy. Students spent one semester becoming familiar with a classroom computer and gaining a general understanding of basic economic concepts through class discussion, field trips, and bulletin boards.…

  8. World lines.

    PubMed

    Waser, Jürgen; Fuchs, Raphael; Ribicić, Hrvoje; Schindler, Benjamin; Blöschl, Günther; Gröller, Eduard

    2010-01-01

    In this paper we present World Lines as a novel interactive visualization that provides complete control over multiple heterogeneous simulation runs. In many application areas, decisions can only be made by exploring alternative scenarios. The goal of the suggested approach is to support users in this decision making process. In this setting, the data domain is extended to a set of alternative worlds where only one outcome will actually happen. World Lines integrate simulation, visualization and computational steering into a single unified system that is capable of dealing with the extended solution space. World Lines represent simulation runs as causally connected tracks that share a common time axis. This setup enables users to interfere and add new information quickly. A World Line is introduced as a visual combination of user events and their effects in order to present a possible future. To quickly find the most attractive outcome, we suggest World Lines as the governing component in a system of multiple linked views and a simulation component. World Lines employ linking and brushing to enable comparative visual analysis of multiple simulations in linked views. Analysis results can be mapped to various visual variables that World Lines provide in order to highlight the most compelling solutions. To demonstrate this technique we present a flooding scenario and show the usefulness of the integrated approach to support informed decision making.

  9. BMI and Risk of Serious Upper Body Injury Following Motor Vehicle Crashes: Concordance of Real-World and Computer-Simulated Observations

    PubMed Central

    Zhu, Shankuan; Kim, Jong-Eun; Ma, Xiaoguang; Shih, Alan; Laud, Purushottam W.; Pintar, Frank; Shen, Wei; Heymsfield, Steven B.; Allison, David B.

    2010-01-01

    Background Men tend to have more upper body mass and fat than women, a physical characteristic that may predispose them to severe motor vehicle crash (MVC) injuries, particularly in certain body regions. This study examined MVC-related regional body injury and its association with the presence of driver obesity using both real-world data and computer crash simulation. Methods and Findings Real-world data were from the 2001 to 2005 National Automotive Sampling System Crashworthiness Data System. A total of 10,941 drivers who were aged 18 years or older involved in frontal collision crashes were eligible for the study. Sex-specific logistic regression models were developed to analyze the associations between MVC injury and the presence of driver obesity. In order to confirm the findings from real-world data, computer models of obese subjects were constructed and crash simulations were performed. According to real-world data, obese men had a substantially higher risk of injury, especially serious injury, to the upper body regions including head, face, thorax, and spine than normal weight men (all p<0.05). A U-shaped relation was found between body mass index (BMI) and serious injury in the abdominal region for both men and women (p<0.05 for both BMI and BMI2). In the high-BMI range, men were more likely to be seriously injured than were women for all body regions except the extremities and abdominal region (all p<0.05 for interaction between BMI and sex). The findings from the computer simulation were generally consistent with the real-world results in the present study. Conclusions Obese men endured a much higher risk of injury to upper body regions during MVCs. This higher risk may be attributed to differences in body shape, fat distribution, and center of gravity between obese and normal-weight subjects, and between men and women. Please see later in the article for the Editors' Summary PMID:20361024

  10. Wood densitometry in 17th and 18th century Dutch, German, Austrian and French violins, compared to classical Cremonese and modern violins.

    PubMed

    Stoel, Berend C; Borman, Terry M; de Jongh, Ronald

    2012-01-01

    Classical violins produced by makers such as Antonio Stradivari and Guarneri del Gesu have long been considered the epitome of the luthier's art and the expressive tool of choice for the most celebrated violinists. It has been speculated these makers had access to wood that was unique in some way and that this was responsible for their acclaimed tonal characteristics. In an attempt to discern whether the above conjecture is true, we analyzed 17 modern and classical Dutch, German, Austrian and French violins by wood densitometry using computed tomography and correlated these results with our previous study of modern and Cremonese violins; in all studying 30 instruments of the violin family. In order to make this comparison possible we developed methods to cross calibrate results from different CT manufacturers using calibration wood pieces. We found no significant differences in median densities between modern and classical violins, or between classical violins from different origins. These results suggest that it is unlikely classical Cremonese makers had access to wood with significantly different wood density characteristics than that available to contemporaneous or modern makers.

  11. Wood Densitometry in 17th and 18th Century Dutch, German, Austrian and French Violins, Compared to Classical Cremonese and Modern Violins

    PubMed Central

    Stoel, Berend C.; Borman, Terry M.; de Jongh, Ronald

    2012-01-01

    Classical violins produced by makers such as Antonio Stradivari and Guarneri del Gesu have long been considered the epitome of the luthier's art and the expressive tool of choice for the most celebrated violinists. It has been speculated these makers had access to wood that was unique in some way and that this was responsible for their acclaimed tonal characteristics. In an attempt to discern whether the above conjecture is true, we analyzed 17 modern and classical Dutch, German, Austrian and French violins by wood densitometry using computed tomography and correlated these results with our previous study of modern and Cremonese violins; in all studying 30 instruments of the violin family. In order to make this comparison possible we developed methods to cross calibrate results from different CT manufacturers using calibration wood pieces. We found no significant differences in median densities between modern and classical violins, or between classical violins from different origins. These results suggest that it is unlikely classical Cremonese makers had access to wood with significantly different wood density characteristics than that available to contemporaneous or modern makers. PMID:23071602

  12. Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

    PubMed Central

    Luo, Feng Roger; Ding, Jian; Chen, Helen X.; Liu, Hao; Fung, Man-Cheong; Koehler, Maria; Armand, Jean Pierre; Jiang, Lei; Xu, Xiao; Zhang, Ge; Xu, Li; Qian, Pascal; Yan, Li

    2014-01-01

    The US Chinese Anti-Cancer Association (USCACA) teamed up with Chinese Society of Clinical Oncology (CSCO) to host a joint session at the17th CSCO Annual Meeting on September 20th, 2014 in Xiamen, China. With a focus on breakthrough cancer medicines, the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and China. The goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China. A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China. PMID:25418191

  13. [Oral health on the public agenda: an analysis of Municipal Health Council records in cities from the 17th Regional Health Division in the State of Paraná, Brazil].

    PubMed

    Alves-Souza, Rosani Aparecida; Saliba, Orlando

    2003-01-01

    The present study analyzes interventions pertaining to oral health recorded in the minutes of meetings held by 15 Municipal Health Councils in cities from the 17th Regional Health Division of the State of Paraná, Brazil. Document analysis was performed by identifying health themes, emphasizing categorization of issues related to interventions in oral health. The most frequently analyzed themes were records concerning the programming and organization of oral health services, followed by health budget issues. In 90 of the 591 minutes studied, 134 records pertaining to oral health interventions were identified. An analysis of the latter showed that oral health interventions involve reports of actions already implemented and lack the characteristics of proposals when analyzed from the health planning perspective. This study highlights the need for dentists to expand their representation in such forums in order to play a broader role in the planning process and support oral health as a basic citizen's right.

  14. The face of conflict: Significant sharp force trauma to the mid-facial skeleton in an individual of probable 16th-17th century date excavated from Byczyna, Poland.

    PubMed

    Cieślik, Agata Izabela; Dąbrowski, Paweł; Przysiężna-Pizarska, Magdalena Anita

    2017-06-01

    A variety of injuries have always been associated with violence, consequences of which people had to deal with. In this paper we present a complex of craniofacial and dental injuries resulted from sharp force trauma. The basis of our study was historical skeletal material excavated from archeological site in Byczyna (11th-17th century), Poland. An individual whose skeleton was exhumed from the grave No. 610 exhibited healed, oblique trauma of the left maxilla, damage to the crowns of right central and lateral incisors and concomitant luxation of the right maxillary central incisor. We describe the mechanism of this trauma and complications that resulted from damage to the masticatory apparatus. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Simulating materials failure by using up to one billion atoms and the world's fastest computer: Work-hardening

    NASA Astrophysics Data System (ADS)

    Abraham, Farid F.; Walkup, Robert; Gao, Huajian; Duchaineau, Mark; Diaz de La Rubia, Tomas; Seager, Mark

    2002-04-01

    We describe the second of two large-scale atomic simulation projects on materials failure performed on the 12-teraflop ASCI (Accelerated Strategic Computing Initiative) White computer at the Lawrence Livermore National Laboratory. This investigation simulates ductile failure by using more than one billion atoms where the true complexity of the creation and interaction of hundreds of dislocations are revealed.

  16. When Learning about the Real World is Better Done Virtually: A Study of Substituting Computer Simulations for Laboratory Equipment

    ERIC Educational Resources Information Center

    Finkelstein, N. D.; Adams, W. K.; Keller, C. J.; Kohl, P. B.; Perkins, K. K.; Podolefsky, N. S.; Reid, S.; LeMaster, R.

    2005-01-01

    This paper examines the effects of substituting a computer simulation for real laboratory equipment in the second semester of a large-scale introductory physics course. The direct current circuit laboratory was modified to compare the effects of using computer simulations with the effects of using real light bulbs, meters, and wires. Two groups of…

  17. When Learning about the Real World is Better Done Virtually: A Study of Substituting Computer Simulations for Laboratory Equipment

    ERIC Educational Resources Information Center

    Finkelstein, N. D.; Adams, W. K.; Keller, C. J.; Kohl, P. B.; Perkins, K. K.; Podolefsky, N. S.; Reid, S.; LeMaster, R.

    2005-01-01

    This paper examines the effects of substituting a computer simulation for real laboratory equipment in the second semester of a large-scale introductory physics course. The direct current circuit laboratory was modified to compare the effects of using computer simulations with the effects of using real light bulbs, meters, and wires. Two groups of…

  18. The 17th Project Integration Meeting

    NASA Technical Reports Server (NTRS)

    Mcdonald, R. R.

    1981-01-01

    Progress made by the Low-Cost Solar Array Project during the period September 1980 to February 1981 is described. Included are reports on project analysis and integration; technology development in silicon material, large-area silicon sheet and encapsulation; production process and equipment development; engineering, and operations. A report on and copies of visual presentations made at the Project Integration Meeting held at Pasadena, California on February 4 and 5, 1981 are also included.

  19. 17th International Microgravity Measurements Group Meeting

    NASA Technical Reports Server (NTRS)

    DeLombard, Richard

    1998-01-01

    The Seventeenth International Microgravity Measurements Group (MGMG) meeting was held 24-26 March 1998 at the Ohio Aerospace Institute (OAI) in Brook Park, Ohio. This meeting focused on the transition of microgravity science research from the Shuttle, Mir, and free flyers to the International Space Station. The MGMG series of meetings are conducted by the Principal Investigator Microgravity Services project of the Microgravity Science Division at the NASA Lewis Research Center. The MGMG meetings provide a forum for the exchange of information and ideas about the microgravity environment and microgravity acceleration research in the Microgravity Research Program. The meeting had participation from investigators in all areas of microgravity research. The attendees included representatives from: NASA centers; National Space Development Agency of Japan; European Space Agency; Daimler Benz Aerospace AG; Deutsches Zentrum fuer Luft- und Raumfahrt; Centre National d'Etudes Spatiales; Canadian Space Agency, national research institutions; Universities in U.S., Italy, Germany, and Russia; and commercial companies in the U.S. and Russia. Several agencies presented summaries of the measurement, analysis, and characterization of the microgravity environment of the Shuttle, Mir, and sounding rockets over the past fifteen years. This extensive effort has laid a foundation for pursuing a similar course during future microgravity science experiment operations on the ISS. Future activities of microgravity environment characterization were discussed by several agencies who plan to operate on the ISS.

  20. The 17th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The proceedings of the Aerospace Mechanisms Symposium are reported. Technological areas covered include space lubrication, aerodynamic devices, spacecraft/Shuttle latches, deployment, positioning, and pointing. Devices for spacecraft tether, magnetic bearing suspension, explosive welding, and a deployable/retractable mast are also described.

  1. Electronics Manufacturing Seminar Proceedings. 17th Annual

    DTIC Science & Technology

    1992-12-01

    the leveler, it was necessary to scrape the solder dross from the I surface of the molten solder. Dross was put into cans for future disposal...manifesting itself as kidney, liver, and nervous system damage; and digestive disorders. ERA OF AWARENESS PERSONNEL Slowly and subtly a culture change...Recycling Rather than send the SnPb solder pot dumpings and dross to salvage, this shop participates in an industry reclamation program. The reclamation

  2. Proceedings, 17th Central Hardwood Forest Conference

    Treesearch

    Songlin Fei; John M. Lhotka; Jeffrey W. Stringer; Kurt W. Gottschalk; Gary W., eds. Miller

    2011-01-01

    Includes 64 papers and 17 abstracts pertaining to research conducted on forest regeneration and propagation, forest products, ecology and forest dynamics, human dimensions and economics, forest biometrics and modeling, silviculture genetics, forest health and protection, and soil and mineral nutrition.

  3. Section 619 Profile. 17th Edition

    ERIC Educational Resources Information Center

    Lazara, Alex; Danaher, Joan; Kraus, Robert; Goode, Sue; Hipps, Cherie; Festa, Cathy

    2010-01-01

    With the passage of P.L. 94-142, the Education for All Handicapped Children Act of 1975, now the Individuals with Disabilities Education Act (IDEA), and subsequent amendments, states and jurisdictions have made great strides in the provision of services to young children, ages 3 through 5 years, with disabilities. As of Fall 2007, America's…

  4. 17th Annual ALS Users' Association Meeting

    SciTech Connect

    Robinson, Art; Tamura, Lori

    2004-11-29

    It's not exactly Russian roulette, but scheduling October events outdoors is not risk-free, even in usually sunny California. An overflow crowd of more than 400 registered users, ALS staff, and vendors enjoyed a full indoor program featuring science highlights and workshops spread over two and a half days from October 18 to October 20. However, a major storm, heralding the onset of the San Francisco Bay Area rainy season, posed a few weather challenges for the events on the ALS patio.

  5. When worlds collide - Mac to MS-DOS. [Data transfer to and from Apple Macintosh computers and MS-DOS based personal computers

    SciTech Connect

    Busbey, A.B.

    1989-04-01

    A number of methods and products, both hardware and software, to allow data exchange between Apple Macintosh computers and MS-DOS based systems. These included serial null modem connections, MS-DOS hardware and/or software emulation, MS-DOS disk-reading hardware and networking.

  6. When learning about the real world is better done virtually: A study of substituting computer simulations for laboratory equipment

    NASA Astrophysics Data System (ADS)

    Finkelstein, N. D.; Adams, W. K.; Keller, C. J.; Kohl, P. B.; Perkins, K. K.; Podolefsky, N. S.; Reid, S.; Lemaster, R.

    2005-12-01

    This paper examines the effects of substituting a computer simulation for real laboratory equipment in the second semester of a large-scale introductory physics course. The direct current circuit laboratory was modified to compare the effects of using computer simulations with the effects of using real light bulbs, meters, and wires. Two groups of students, those who used real equipment and those who used a computer simulation that explicitly modeled electron flow, were compared in terms of their mastery of physics concepts and skills with real equipment. Students who used the simulated equipment outperformed their counterparts both on a conceptual survey of the domain and in the coordinated tasks of assembling a real circuit and describing how it worked.

  7. World Congress on Computational Mechanics, 2nd, Universitaet Stuttgart, Federal Republic of Germany, Aug. 27-31, 1990, Selected Papers

    NASA Astrophysics Data System (ADS)

    Argyris, John; Doltsinis, Ioannis St.; Oden, J. T.

    The present conference on computer methods in applied mechanics and engineering encompasses methods for describing fluids, structures, dynamics, applied physics, and computing and numerical methods. Specific issues addressed include h-p adaptive finite-element methods in computational fluid dynamics, simulations of hypersonic viscous flows about the H-II orbiting plane, chemically reacting hypersonic viscous flows, a numerical model for buckling and growth of delaminations in composite laminates, and CAD-integrated structural topology and design optimization. Also addressed are defect-mediated turbulence, geometrical concepts of nonlinear dynamics, vertical solidification of dendritic binary alloys, the parallelization of CFD codes, the integration of solid modeling and finite-element generation, studies of parallel processing for coupled-field problems, and an information system for the numerical simulation of 3D Euler flows around aircraft.

  8. From the Cover: Simulating materials failure by using up to one billion atoms and the world's fastest computer: Brittle fracture

    NASA Astrophysics Data System (ADS)

    Abraham, Farid F.; Walkup, Robert; Gao, Huajian; Duchaineau, Mark; Diaz de La Rubia, Tomas; Seager, Mark

    2002-04-01

    We describe the first of two large-scale atomic simulation projects on materials failure performed on the 12-teraflop ASCI (Accelerated Strategic Computing Initiative) White computer at Lawrence Livermore National Laboratory. This is a multimillion-atom simulation study of crack propagation in rapid brittle fracture where the cracks travel faster than the speed of sound. Our finding centers on a bilayer solid that behaves under large strain like an interface crack between a soft (linear) material and a stiff (nonlinear) material. We verify that the crack behavior is dominated by the local (nonlinear) wave speeds, which can be in excess of the conventional sound speeds of a solid.

  9. Simulating materials failure by using up to one billion atoms and the world's fastest computer: Brittle fracture

    PubMed Central

    Abraham, Farid F.; Walkup, Robert; Gao, Huajian; Duchaineau, Mark; Diaz De La Rubia, Tomas; Seager, Mark

    2002-01-01

    We describe the first of two large-scale atomic simulation projects on materials failure performed on the 12-teraflop ASCI (Accelerated Strategic Computing Initiative) White computer at Lawrence Livermore National Laboratory. This is a multimillion-atom simulation study of crack propagation in rapid brittle fracture where the cracks travel faster than the speed of sound. Our finding centers on a bilayer solid that behaves under large strain like an interface crack between a soft (linear) material and a stiff (nonlinear) material. We verify that the crack behavior is dominated by the local (nonlinear) wave speeds, which can be in excess of the conventional sound speeds of a solid. PMID:16578876

  10. FuturICT: Participatory computing to understand and manage our complex world in a more sustainable and resilient way

    NASA Astrophysics Data System (ADS)

    Helbing, D.; Bishop, S.; Conte, R.; Lukowicz, P.; McCarthy, J. B.

    2012-11-01

    We have built particle accelerators to understand the forces that make up our physical world. Yet, we do not understand the principles underlying our strongly connected, techno-socio-economic systems. We have enabled ubiquitous Internet connectivity and instant, global information access. Yet we do not understand how it impacts our behavior and the evolution of society. To fill the knowledge gaps and keep up with the fast pace at which our world is changing, a Knowledge Accelerator must urgently be created. The financial crisis, international wars, global terror, the spreading of diseases and cyber-crime as well as demographic, technological and environmental change demonstrate that humanity is facing serious challenges. These problems cannot be solved within the traditional paradigms. Moving our attention from a component-oriented view of the world to an interaction-oriented view will allow us to understand the complex systems we have created and the emergent collective phenomena characterising them. This paradigm shift will enable new solutions to long-standing problems, very much as the shift from a geocentric to a heliocentric worldview has facilitated modern physics and the ability to launch satellites. The FuturICT flagship project will develop new science and technology to manage our future in a complex, strongly connected world. For this, it will combine the power of information and communication technology (ICT) with knowledge from the social and complexity sciences. ICT will provide the data to boost the social sciences into a new era. Complexity science will shed new light on the emergent phenomena in socially interactive systems, and the social sciences will provide a better understanding of the opportunities and risks of strongly networked systems, in particular future ICT systems. Hence, the envisaged FuturICT flagship will create new methods and instruments to tackle the challenges of the 21st century. FuturICT could indeed become one of the most

  11. A combined Raman microscopy, XRF and SEM-EDX study of three valuable objects - A large painted leather screen and two illuminated title pages in 17th century books of ordinances of the Worshipful Company of Barbers, London

    NASA Astrophysics Data System (ADS)

    Chaplin, Tracey D.; Clark, Robin J. H.; Martinón-Torres, Marcos

    2010-07-01

    Raman microscopy has been used to identify the pigments decorating three valuable items owned by the Worshipful Company of Barbers (established in 1308 in London), one being a large leather screen dating to before 1712, the other two being illuminated title pages of books of ordinances of the Company dating to 1605 and 1658. Pigments which could not be fully characterised by this technique (particularly the green paints) have also been subject to XRF or SEM-EDX analysis. The combined analytical approach has shown that the pigments identified on all three items are typical of those in use as artists' pigments in the 17th C and include azurite, indigo, vermilion, red lead, pink and yellow lakes, verdigris, lead white, calcite (and chalk), gypsum, carbon-based black, and gold and silver leaf. However in the case of the screen alone, restoration in the 1980s has been carried out with different pigments - haematite, phthalocyanine green, rutile, and a mixture of azurite, malachite and barium sulfate. This work constitutes the first in-depth study of painted leatherwork and demonstrates that the palette used for this purpose is similar to that used on other works of art of the same date. It has also allowed the original colour schemes of the decorations to be determined where pigment degradation has occurred. The combined analysis has also provided a more complete understanding of the materials used for, or on, objects to which access is limited.

  12. The proceedings of the 17th International Conference on Chelation: application of effective chelation therapies in iron loading and non iron loading conditions, and the gap in the prevention and treatment policies on thalassemia between developed and developing countries.

    PubMed

    Kontoghiorghes, George J

    2009-01-01

    Substantial progress in the use of chelating drugs for the treatment of iron overload and of non iron loading conditions has been presented during the 17th International Conference on Chelation (ICOC) held in November 2007 at Shenzhen, China. Major challenges lie ahead for the prevention and treatment of thalassemia in China, India, Thailand, Indonesia and many other developing countries where millions of heterozygote thalassemia carriers live and thousands of homozygote thalassemia patients are born annually. The progressive improvement of the economic climate in developing countries will increase the demand and resources for more prenatal and antenatal diagnoses, transfusions and chelation therapy in forthcoming years. Despite the major advances in diagnosis and treatment in developed countries, the vast majority of thalassemia patients in developing countries die untreated because they cannot afford the cost of transfusions and chelation therapy. New approaches and infrastructures and more efforts are needed to overcome the difficulties of supplying new techniques and treatments to patients in developing countries. International and local organizations need to be persuaded to act collectively and effectively to improve chelation and related treatments for thalassemia and other conditions, especially at this time that universally effective and inexpensive chelation therapies can be applied.

  13. The potential for non-invasive study of mummies: validation of the use of computerized tomography by post factum dissection and histological examination of a 17th century female Korean mummy.

    PubMed

    Lim, Do-Seon; Lee, In Sun; Choi, Ki-Ju; Lee, Soong Deok; Oh, Chang Seok; Kim, Yi-Suk; Bok, Gi Dae; Kim, Myeung Ju; Yi, Yang Su; Lee, Eun-Joo; Shin, Dong Hoon

    2008-10-01

    The socio-cultural antipathies of some descendants with regard to invasive examinations of age-old human remains make permission for dissection of Korean mummies of the Joseon Dynasty (1392-1910) difficult to obtain. Overcoming this obstacle necessitated the use of non-invasive techniques, such as multi-detector computerized tomography (MDCT) and endoscopic examination, enabling determination of the preservation status of internal organs of mummies without significantly damaging the mummies themselves. However, MDCT alone cannot clearly differentiate specific mummified organs. Therefore, in much the same way as diagnostic radiologists make their MDCT readings on living patients more reliable by means of comparison with accumulated post-factum data from autopsies or histological studies, examinations of mummies by invasive techniques should not be decried as mere destruction of age-old human remains. Rather, providing that due permission from descendants and/or other relevant authorities can be obtained, dissection and histological examination should be performed whenever opportunities arise. Therefore, in this study, we compared the radiological data acquired from a 17th century mummy with our dissection results for the same subject. As accumulation of this kind of data could be very crucial for correct interpretation of MDCT findings on Korean mummies, we will perform similar trials on other Korean mummies found in forthcoming days if conditions permit.

  14. Skull deformations in craniosynostosis and endocrine disorders: morphological and tomographic analysis of the skull from the crypt of the Silesian Piasts in Brzeg (16th-17th century), Poland.

    PubMed

    Kozłowski, T; Cybulska, M; Błaszczyk, B; Krajewska, M; Jeśman, C

    2014-10-01

    of morphological and tomographic (CT) studies of the skull that was found in the crypt of the Silesian Piasts in the St. Jadwiga church in Brzeg (Silesia, Poland) are presented and discussed here. The established date of burial of probably a 20-30 years old male was 16th-17th century. The analyzed skull showed premature obliteration of the major skull sutures. It resulted in the braincase deformation, similar to the forms found in oxycephaly and microcephaly. Tomographic analysis revealed gross pathology. Signs of increased intracranial pressure, basilar invagination and hypoplasia of the occipital bone were observed. Those results suggested the occurrence of the very rare Arnold-Chiari syndrome. Lesions found in the sella turcica indicated the development of pituitary macroadenoma, which resulted in the occurrence of discreet features of acromegaly in the facial bones. The studied skull was characterized by a significantly smaller size of the neurocranium (horizontal circumference 471 mm, cranial capacity ∼ 1080 ml) and strongly expressed brachycephaly (cranial index=86.3), while its height remained within the range for non-deformed skulls. A narrow face, high eye-sockets and prognathism were also observed. Signs of alveolar process hypertrophy with rotation and displacement of the teeth were noted. The skull showed significant morphological differences compared to both normal and other pathological skulls such as those with pituitary gigantism, scaphocephaly and microcephaly. Copyright © 2014 Elsevier GmbH. All rights reserved.

  15. The potential for non-invasive study of mummies: validation of the use of computerized tomography by post factum dissection and histological examination of a 17th century female Korean mummy

    PubMed Central

    Lim, Do-Seon; Lee, In Sun; Choi, Ki-Ju; Lee, Soong Deok; Oh, Chang Seok; Kim, Yi-Suk; Bok, Gi Dae; Kim, Myeung Ju; Yi, Yang Su; Lee, Eun-Joo; Shin, Dong Hoon

    2008-01-01

    The socio-cultural antipathies of some descendants with regard to invasive examinations of age-old human remains make permission for dissection of Korean mummies of the Joseon Dynasty (1392–1910) difficult to obtain. Overcoming this obstacle necessitated the use of non-invasive techniques, such as multi-detector computerized tomography (MDCT) and endoscopic examination, enabling determination of the preservation status of internal organs of mummies without significantly damaging the mummies themselves. However, MDCT alone cannot clearly differentiate specific mummified organs. Therefore, in much the same way as diagnostic radiologists make their MDCT readings on living patients more reliable by means of comparison with accumulated post-factum data from autopsies or histological studies, examinations of mummies by invasive techniques should not be decried as mere destruction of age-old human remains. Rather, providing that due permission from descendants and/or other relevant authorities can be obtained, dissection and histological examination should be performed whenever opportunities arise. Therefore, in this study, we compared the radiological data acquired from a 17th century mummy with our dissection results for the same subject. As accumulation of this kind of data could be very crucial for correct interpretation of MDCT findings on Korean mummies, we will perform similar trials on other Korean mummies found in forthcoming days if conditions permit. PMID:19014355

  16. Our World Their World

    ERIC Educational Resources Information Center

    Brisco, Nicole

    2011-01-01

    Build, create, make, blog, develop, organize, structure, perform. These are just a few verbs that illustrate the visual world. These words create images that allow students to respond to their environment. Visual culture studies recognize the predominance of visual forms of media, communication, and information in the postmodern world. This…

  17. Our World Their World

    ERIC Educational Resources Information Center

    Brisco, Nicole

    2011-01-01

    Build, create, make, blog, develop, organize, structure, perform. These are just a few verbs that illustrate the visual world. These words create images that allow students to respond to their environment. Visual culture studies recognize the predominance of visual forms of media, communication, and information in the postmodern world. This…

  18. Intelligent computer aided training systems in the real world: Making the technology accessible to the educational mainstream

    NASA Technical Reports Server (NTRS)

    Kovarik, Madeline

    1993-01-01

    Intelligent computer aided training systems hold great promise for the application of this technology to mainstream education and training. Yet, this technology, which holds such a vast potential impact for the future of education and training, has had little impact beyond the enclaves of government research labs. This is largely due to the inaccessibility of the technology to those individuals in whose hands it can have the greatest impact, teachers and educators. Simply throwing technology at an educator and expecting them to use it as an effective tool is not the answer. This paper provides a background into the use of technology as a training tool. MindLink, developed by HyperTech Systems, provides trainers with a powerful rule-based tool that can be integrated directly into a Windows application. By embedding expert systems technology it becomes more accessible and easier to master.

  19. Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentrations in children from a 17(th)-18(th) century cemetery in Jēkabpils, Latvia.

    PubMed

    Zariņa, Gunita; Sholts, Sabrina B; Tichinin, Alina; Rudovica, Vita; Vīksna, Arturs; Engīzere, Austra; Muižnieks, Vitolds; Bartelink, Eric J; Wärmländer, Sebastian K T S

    2016-12-01

    Cribra orbitalia (CO), or porotic hyperostosis (PH) of the orbital roof, is one of the most common pathological conditions found in archaeological subadult skeletal remains. Reaching frequencies higher than 50% in many prehistoric samples, CO has been generally attributed to a variety of factors including malnutrition (e.g., megaloblastic anemia) and parasitism. In this study, we tested the relationship between CO, trace element concentrations, and stable isotope values (δ(13)C, δ(15)N, δ(18)O) in subadult skeletons from a 17(th) to 18(th) century cemetery in the historic town of Jēkabpils, Latvia. A total of 28 subadults were examined, seven of which (25%) showed evidence of CO. Bioarchaeological evidence indicated high mortality for children in this cemetery: half of the burials were subadults under the age of 14, while a third were under the age of four. Life expectancy at birth was estimated to have been only 21.6 years. Trace element concentrations measured by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) showed no relationship between presence or absence of CO and levels of manganese, zinc, strontium, barium, copper, cadmium, or lead in the bones (p>0.05). However, a significant correlation (p<0.05) was found between the presence of CO and decreased levels of iron. The correlations between CO and decreased levels of copper and lead approached significance (p=0.056 for both elements). Individuals with CO furthermore displayed significantly lower δ(15)N isotope values, suggesting greater consumption of lower trophic level food resources than those unaffected by CO; δ(13)C and δ(18)O values, in contrast, showed no significant differences. These results suggest that the prevalence of CO may be related to dietary deficiencies. In this case, low iron levels may also signify a diet low in other key vitamins (e.g., B9 and B12), which are known to cause megaloblastic anemia. Copyright © 2016 Elsevier GmbH. All rights reserved.

  20. Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4(+) T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling.

    PubMed

    Zhang, Hongjun; Ju, Baoling; Zhang, Xiaoli; Zhu, Yanfei; Nie, Ying; Xu, Yuanhong; Lei, Qiuxia

    2016-12-29

    Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA, 8 mg/kg/week) up to 6 weeks to establish hepatic fibrosis, and magnolol (10, 20, 30 mg/kg/day) was given to these mice orally throughout the whole experiment. We found that magnolol preserved liver function and attenuated liver fibrotic injury in vivo. In response to ConA stimulation, the CD4(+) T cells preferred to polarizing towards CD4(+) T helper 17 (Th17) cells in liver. Magnolol was observed to inhibit Th17 cell differentiation in ConA-treated liver in addition to suppressing interleukin (IL)-17A generation. Hepatic stellate cells were activated in fibrotic liver as demonstrated by increased alpha smooth muscle actin (α-SMA) and desmin. More transforming growth factor (TGF)-β1 and activin A were secreted into the serum. Magnolol suppressed this abnormal HSC activation. Furthermore, the phosphorylation of Smad3 in its linker area (Thr179, Ser 204/208/213) was inhibited by magnolol. In vitro, the recombinant IL-17A plus TGF-β1 or activin A induced activation of human LX2 HSCs and promoted their collagen production. Smad3/Smad4 signalling pathway was activated in LX2 cells exposed to the fibrotic stimuli, as illustrated by the up-regulated phospho-Smad3 and the enhanced interaction between Smad3 and Smad4. These alterations were suppressed by magnolol. Collectively, our study reveals a novel antifibrotic effect of magnolol on Th17 cell-mediated fibrosis.

  1. Determination and validation of criteria to define hypercementosis in two medieval samples from France (Sains-en-Gohelle, AD 7th-17th century; Jau-Dignac-et-Loirac, AD 7th-8th century).

    PubMed

    d'Incau, Emmanuel; Couture, Christine; Crépeau, Natacha; Chenal, Fanny; Beauval, Cédric; Vanderstraete, Vincent; Maureille, Bruno

    2015-02-01

    The main aim of this article was to develop different visual criteria allowing for an objective definition of hypercementosis (cementum hyperplasia). This preliminary study must notably show how to better understand at a later stage the significance of its frequency as well as its aetiologies, especially in past populations. we set up a study protocol (macroscopic and photographic observations) on material consisting of 2 medieval samples from France (1) Sains-en-Gohelle sample-SG (AD 7th-17th century; 407 individuals; 5756 teeth observed, 319 with hypercementosis) which was used to develop the different criteria for defining hypercementosis (2) Jau-Dignac-et-Loirac sample-JDL (AD 7th-8th century; 55 individuals; 709 teeth observed, 24 with hypercementosis) which was used to test the reproducibility of the criteria. From our observations we formulated different inclusion criteria with which to define hypercementosis objectively (k intraobserver≥0.96; k interobserver≥0.63). We were able to distinguish moderate (1m) and marked (1M) forms of diffuse hypercementosis, focal hypercementosis in the form of small knots (2m) or large nodules (2M), or excrescences in the form of ridges (3m) or spurs (3M). Different exclusion criteria were also determined. The definition that we propose in this study are based on various statistically validated inclusion and exclusion criteria. It is hoped that this will improve the significance of hypercementosis. More generally, this would also give a better understanding of the dynamics of cementum apposition. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. A computational tool for evaluating THz imaging performance in brownout or whiteout conditions at land sites throughout the world

    NASA Astrophysics Data System (ADS)

    Fiorino, Steven T.; Bartell, Richard J.; Krizo, Matthew J.; Marek, Seth L.; Bohn, Matthew J.; Randall, Robb M.; Cusumano, Salvatore J.

    2009-05-01

    This study quantifies terahertz (THz) or sub-millimeter imaging performance during simulated rotary-wing brownout or whiteout environments based on geographic location and recent/current atmospheric weather conditions. The atmospheric conditions are defined through the Air Force Institute of Technology Center for Directed Energy (AFIT/CDE) Laser Environmental Effects Definition and Reference or LEEDR model. This model enables the creation of vertical profiles of temperature, pressure, water vapor content, optical turbulence, and atmospheric particulates and hydrometeors as they relate to line-by-line layer extinction coefficient magnitude at wavelengths from the UV to the RF. Optical properties and realistic particle size distributions for the brownout and whiteout particulates have been developed for and incorporated into LEEDR for this study. The expected imaging performance is assessed primarily at a wavelength of 454 μm (0.66 THz) in brownout conditions at selected geographically diverse land sites throughout the world. Seasonal and boundary layer variations (summer and winter) and time of day variations for a range of relative humidity percentile conditions are considered to determine optimum employment techniques to exploit or defeat the environmental conditions. Each atmospheric particulate/hydrometeor is evaluated based on its wavelength-dependent forward and off-axis scattering characteristics and absorption effects on the imaging environment. In addition to realistic vertical profiles of molecular and aerosol absorption and scattering, correlated optical turbulence profiles in probabilistic (percentile) format are used. Most evaluated scenarios are brownout environments over ranges up to 50 meters. At submillimeter wavelengths and the short ranges studied, preliminary results indicate the main source of image degradation in brownout conditions is water vapor content, even with visibility less than 10 m and strong optical turbulence.

  3. Computer Stimulation

    ERIC Educational Resources Information Center

    Moore, John W.; Moore, Elizabeth

    1977-01-01

    Discusses computer simulation approach of Limits to Growth, in which interactions of five variables (population, pollution, resources, food per capita, and industrial output per capita) indicate status of the world. Reviews other books that predict future of the world. (CS)

  4. iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan.

    PubMed

    Tsai, Tsung-Ying; Chang, Kai-Wei; Chen, Calvin Yu-Chian

    2011-06-01

    The rapidly advancing researches on traditional Chinese medicine (TCM) have greatly intrigued pharmaceutical industries worldwide. To take initiative in the next generation of drug development, we constructed a cloud-computing system for TCM intelligent screening system (iScreen) based on TCM Database@Taiwan. iScreen is compacted web server for TCM docking and followed by customized de novo drug design. We further implemented a protein preparation tool that both extract protein of interest from a raw input file and estimate the size of ligand bind site. In addition, iScreen is designed in user-friendly graphic interface for users who have less experience with the command line systems. For customized docking, multiple docking services, including standard, in-water, pH environment, and flexible docking modes are implemented. Users can download first 200 TCM compounds of best docking results. For TCM de novo drug design, iScreen provides multiple molecular descriptors for a user's interest. iScreen is the world's first web server that employs world's largest TCM database for virtual screening and de novo drug design. We believe our web server can lead TCM research to a new era of drug development. The TCM docking and screening server is available at http://iScreen.cmu.edu.tw/.

  5. iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

    NASA Astrophysics Data System (ADS)

    Tsai, Tsung-Ying; Chang, Kai-Wei; Chen, Calvin Yu-Chian

    2011-06-01

    The rapidly advancing researches on traditional Chinese medicine (TCM) have greatly intrigued pharmaceutical industries worldwide. To take initiative in the next generation of drug development, we constructed a cloud-computing system for TCM intelligent screening system (iScreen) based on TCM Database@Taiwan. iScreen is compacted web server for TCM docking and followed by customized de novo drug design. We further implemented a protein preparation tool that both extract protein of interest from a raw input file and estimate the size of ligand bind site. In addition, iScreen is designed in user-friendly graphic interface for users who have less experience with the command line systems. For customized docking, multiple docking services, including standard, in-water, pH environment, and flexible docking modes are implemented. Users can download first 200 TCM compounds of best docking results. For TCM de novo drug design, iScreen provides multiple molecular descriptors for a user's interest. iScreen is the world's first web server that employs world's largest TCM database for virtual screening and de novo drug design. We believe our web server can lead TCM research to a new era of drug development. The TCM docking and screening server is available at http://iScreen.cmu.edu.tw/.

  6. World population beyond six billion.

    PubMed

    Gelbard, A; Haub, C; Kent, M M

    1999-03-01

    This world report reviews population growth pre-1900, population change during 1900-50 and 1950-2000, causes and effects of population change and projections to 2050. World population grew from 2 billion in 1900 to almost 6 billion in 2000. Population showed more rapid growth in the 17th and 18th centuries. Better hygiene and public sanitation in the 19th century led to expanded life expectancies and quicker growth, primarily in developed countries. Demographic transition in the 19th and 20th centuries was the result of shifts from high to low mortality and fertility. The pace of change varies with culture, level of economic development, and other factors. Not all countries follow the same path of change. The reproductive revolution in the mid-20th century and modern contraception led to greater individual control of fertility and the potential for rapid fertility decline. Political and cultural barriers that limit access affect the pace of decline. Population change is also affected by migration. Migration has the largest effect on the distribution of population. Bongaarts explains differences in fertility by the proportion in unions, contraceptive prevalence, infertility, and abortion. Educational status has a strong impact on adoption of family planning. Poverty is associated with multiple risks. In 2050, population could reach 10.7 billion or remain low at 7.3 billion.

  7. Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status.

    PubMed

    Araujo-Pires, Ana Claudia; Francisconi, Carolina Favaro; Biguetti, Claudia Cristina; Cavalla, Franco; Aranha, Andreza Maria Fabio; Letra, Ariadne; Trombone, Ana Paula Favaro; Faveri, Marcelo; Silva, Renato Menezes; Garlet, Gustavo Pompermaier

    2014-01-01

    Previous studies demonstrate that the balance between pro- and anti-inflammatory mediators determines the stable or progressive nature of periapical granulomas by modulating the balance of the osteoclastogenic factor RANKL and its antagonist OPG. However, the cytokine networks operating in the development of periapical lesions are quite more complex than what the simple pro- versus anti-inflammatory mediators' paradigm suggests. Here we simultaneously investigated the patterns of Th1, Th2, Th9, Th17, Th22, Thf, Tr1 and Tregs cytokines/markers expression in human periapical granulomas. The expression of TNF-α, IFN-γ, IL-17A, IL23, IL21, IL-33, IL-10, IL-4, IL-9, IL-22, FOXp3 markers (via RealTimePCR array) was accessed in active/progressive (N=40) versus inactive/stable (N=70) periapical granulomas (as determined by RANKL/OPG expression ratio), and also to compare these samples with a panel of control specimens (N=26). A cluster analysis of 13 cytokine levels was performed to examine possible clustering between the cytokines in a total of 110 granulomas. The expression of all target cytokines was higher in the granulomas than in control samples. TNF-α, IFN-γ, IL-17A and IL-21 mRNA levels were significantly higher in active granulomas, while in inactive lesions the expression levels of IL-4, IL-9, IL-10, IL-22 and FOXp3 were higher than in active granulomas. Five clusters were identified in inactive lesion groups, being the variance in the expression levels of IL-17, IL-10, FOXp3, IFN-γ, IL-9, IL-33 and IL-4 statistically significant (KW p<0.05). Three clusters were identified in active lesions, being the variance in the expression levels of IL-22, IL-10, IFN-γ, IL-17, IL-33, FOXp3, IL-21 and RANKL statistically significant (KW p<0.05). There is a clear dichotomy in the profile of cytokine expression in inactive and active periapical lesions. While the widespread cytokine expression seems to be a feature of chronic lesions, hierarchical cluster analysis

  8. Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status

    PubMed Central

    ARAUJO-PIRES, Ana Claudia; FRANCISCONI, Carolina Favaro; BIGUETTI, Claudia Cristina; CAVALLA, Franco; ARANHA, Andreza Maria Fabio; LETRA, Ariadne; TROMBONE, Ana Paula Favaro; FAVERI, Marcelo; SILVA, Renato Menezes; GARLET, Gustavo Pompermaier

    2014-01-01

    Previous studies demonstrate that the balance between pro- and anti-inflammatory mediators determines the stable or progressive nature of periapical granulomas by modulating the balance of the osteoclastogenic factor RANKL and its antagonist OPG. However, the cytokine networks operating in the development of periapical lesions are quite more complex than what the simple pro- versus anti-inflammatory mediators' paradigm suggests. Here we simultaneously investigated the patterns of Th1, Th2, Th9, Th17, Th22, Thf, Tr1 and Tregs cytokines/markers expression in human periapical granulomas. Methods The expression of TNF-α, IFN-γ, IL-17A, IL23, IL21, IL-33, IL-10, IL-4, IL-9, IL-22, FOXp3 markers (via RealTimePCR array) was accessed in active/progressive (N=40) versus inactive/stable (N=70) periapical granulomas (as determined by RANKL/OPG expression ratio), and also to compare these samples with a panel of control specimens (N=26). A cluster analysis of 13 cytokine levels was performed to examine possible clustering between the cytokines in a total of 110 granulomas. Results The expression of all target cytokines was higher in the granulomas than in control samples. TNF-α, IFN-γ, IL-17A and IL-21 mRNA levels were significantly higher in active granulomas, while in inactive lesions the expression levels of IL-4, IL-9, IL-10, IL-22 and FOXp3 were higher than in active granulomas. Five clusters were identified in inactive lesion groups, being the variance in the expression levels of IL-17, IL-10, FOXp3, IFN-γ, IL-9, IL-33 and IL-4 statistically significant (KW p<0.05). Three clusters were identified in active lesions, being the variance in the expression levels of IL-22, IL-10, IFN-γ, IL-17, IL-33, FOXp3, IL-21 and RANKL statistically significant (KW p<0.05). Conclusion There is a clear dichotomy in the profile of cytokine expression in inactive and active periapical lesions. While the widespread cytokine expression seems to be a feature of chronic lesions

  9. Cloud Computing

    SciTech Connect

    Pete Beckman and Ian Foster

    2009-12-04

    Chicago Matters: Beyond Burnham (WTTW). Chicago has become a world center of "cloud computing." Argonne experts Pete Beckman and Ian Foster explain what "cloud computing" is and how you probably already use it on a daily basis.

  10. How much longer must medicine's science be bound by a seventeenth century world view?

    PubMed

    Engel, G L

    1992-01-01

    The exclusion of nonmaterial human phenomena mandated by medical science's continuing allegiance to a 17th century scientific world view has constituted a major obstacle to medicine's scientific maturation as a human discipline. But 20th century conceptual changes even in physics (not to mention the influence of the theory of evolution) now renders that exclusion untenable and in effect legitimizes efforts to devise scientific means appropriate for the human domain. Practical as well as theoretical issues involved in such an undertaking are discussed within the framework of a 20th century scientific world view as represented by the biopsychosocial model, a counterpart to the traditional biomedical model.

  11. Worlds Fantastic, Worlds Familiar

    NASA Astrophysics Data System (ADS)

    Buratti, Bonnie J.

    2017-02-01

    Introduction; 1. Mercury: the hottest little place; 2. Venus: an even hotter place; 3. Mars: the abode of life?; 4. Asteroids and comets: sweat the small stuff; 5. Galileo's treasures: worlds of fire and ice; 6. Enceladus: an active iceball in space; 7. Titan: an Earth in deep freeze?; 8. Iapetus and its friends: the weirdest 'planets' in the Solar System; 9. Pluto: the first view of the 'third zone'; 10. Earths above: the search for exoplanets and life in the universe; Epilogue; Glossary; Acknowledgements; Index.

  12. Trends of Students of the College of Basic Science towards Teaching the Course of Athletics and Health by Using Computer Technology in the World Islamic Sciences and Education University (WISE)

    ERIC Educational Resources Information Center

    Salameh, Ibrahim Abdul Ghani; Khawaldeh, Mohammad Falah Ali

    2014-01-01

    The Study aimed at identifying the trends of the students of basic sciences College in the World Islamic Sciences and Education University towards teaching health and sport course by using computer technology as a teaching method, and to identify also the impact of the variables of academic level and the gender on the students' trends. The study…

  13. Three-dimensional echocardiography in various types of heart disease: a comparison study of magnetic resonance imaging and 64-slice computed tomography in a real-world population.

    PubMed

    Squeri, Angelo; Censi, Stefano; Reverberi, Claudio; Gaibazzi, Nicola; Baldelli, Marco; Binno, Simone Maurizio; Properzi, Enrico; Bosi, Stefano

    2017-03-01

    Accurate quantification of left ventricular (LV) volumes [end-diastolic volume (EDV) and end-systolic volume (ESV)] and ejection fraction (EF) is of critical importance. The development of real-time three-dimensional echocardiography (RT3DE) has shown better correlation than two-dimensional (2D) echocardiography with magnetic resonance imaging (MRI) measurements. The aim of our study was to assess the accuracy of RT3DE and 64-slice computed tomography (CT) in the evaluation of LV volumes and function using MRI as the reference standard in a real-world population with various types of heart disease with different chamber geometry. The study population consisted of 66 patients referred for cardiac MRI for various pathologies. All patients underwent cardiac MRI, and RT3DE and 64 slices CT were then performed on a subsequent day. The study population was then divided into 5 clinical groups depending on the underlying heart disease. RT3DE volumes correlated well with MRI values (R (2) values: 0.90 for EDV and 0.94 for ESV). RT3DE measurements of EF correlated well with MRI values (R (2) = 0.86). RT3DE measurements resulted in slightly underestimated values of both EDV and ESV, as reflected by biases of -9.18 and -4.50 mL, respectively. Comparison of RT3DE and MRI in various types of cardiomyopathies showed no statistical difference between different LV geometrical patterns. These results confirm that RT3DE has good accuracy in everyday clinical practice and can be of clinical utility in all types of cardiomyopathy independently of LV geometric pattern, LV diameter or wall thickness, taking into account a slight underestimation of LV volumes and EF compared to MRI.

  14. Complex Demands on Teaching Require Innovation: Case Method & Other Techniques. Selected Papers of the International Conference on Case Method Research & Application (17th, Budapest, Hungary, July 2-5, 2000).

    ERIC Educational Resources Information Center

    Klein, Hans E., Ed.

    This book presents a selection of papers from the annual, international, interdisciplinary conference of the World Association for Case Method Research & Application. Papers are categorized into six areas: (1) "Case Studies and Research" (e.g., subjectivity as a source of insight in case study research, evolution of a teaching case,…

  15. Complex Demands on Teaching Require Innovation: Case Method & Other Techniques. Selected Papers of the International Conference on Case Method Research & Application (17th, Budapest, Hungary, July 2-5, 2000).

    ERIC Educational Resources Information Center

    Klein, Hans E., Ed.

    This book presents a selection of papers from the annual, international, interdisciplinary conference of the World Association for Case Method Research & Application. Papers are categorized into six areas: (1) "Case Studies and Research" (e.g., subjectivity as a source of insight in case study research, evolution of a teaching case,…

  16. Alice in the Real World

    ERIC Educational Resources Information Center

    Parker, Tom

    2012-01-01

    As a fifth-grade mathematics teacher, the author tries to create authentic problem-solving activities that connect to the world in which his students live. He discovered a natural connection to his students' real world at a computer camp. A friend introduced him to Alice, a computer application developed at Carnegie Mellon, under the leadership of…

  17. Alice in the Real World

    ERIC Educational Resources Information Center

    Parker, Tom

    2012-01-01

    As a fifth-grade mathematics teacher, the author tries to create authentic problem-solving activities that connect to the world in which his students live. He discovered a natural connection to his students' real world at a computer camp. A friend introduced him to Alice, a computer application developed at Carnegie Mellon, under the leadership of…

  18. Distributed Pervasive Worlds: The Case of Exergames

    ERIC Educational Resources Information Center

    Laine, Teemu H.; Sedano, Carolina Islas

    2015-01-01

    Pervasive worlds are computing environments where a virtual world converges with the physical world through context-aware technologies such as sensors. In pervasive worlds, technology is distributed among entities that may be distributed geographically. We explore the concept, possibilities, and challenges of distributed pervasive worlds in a case…

  19. Distributed Pervasive Worlds: The Case of Exergames

    ERIC Educational Resources Information Center

    Laine, Teemu H.; Sedano, Carolina Islas

    2015-01-01

    Pervasive worlds are computing environments where a virtual world converges with the physical world through context-aware technologies such as sensors. In pervasive worlds, technology is distributed among entities that may be distributed geographically. We explore the concept, possibilities, and challenges of distributed pervasive worlds in a case…

  20. [World microbiological unification according to Woodrow Borah].

    PubMed

    Sabbatani, Sergio

    2002-12-01

    Now that developments in communication media are turning the world into a "global village" and there are risks of global epidemics due to infectious agents spread by possible terrorist attacks, this article aims to remind us of what happened in the "New World", where in the space of a few decades the indigenous civilizations disappeared. When, following the geographical discoveries of the 15th, 16th and 17th centuries, millions of people met European sailors, soldiers and traders, the outbreak of pathocenosis was destructive--the intensity of this effect was directly related to the degree of isolation of the indigenous populations colonised by the Europeans. The author of this article recalls the Woodrow Borah thesis. Borah, a former History Professor at Berkeley University, elaborated a theory according to which the microbiological unification of the world is the prime cause of the genocide of the indigenous population in America and Oceania. The author emphasises that the events following the discovery of the American continent are very similar to the plague epidemic which started in 1348 in Europe.

  1. World oil

    NASA Astrophysics Data System (ADS)

    Sweeney, J. L.

    1982-06-01

    Results obtained through the application of 10 prominent world oil or world energy models to 12 scenarios are reported. These scenarios were designed to bound the range of likely future world oil market outcomes. Conclusions relate to oil market trends, impacts of policies on oil prices, security of oil supplies, impacts of policies on oil security problems, use of the oil import premium in policymaking, the transition to oil substitutes, and the state of the art of world oil modeling.

  2. On TESOL '83. The Question of Control. Selected Papers from the Annual Convention of Teachers of English to Speakers of Other Languages (17th, Toronto, Canada, March 15-20, 1983).

    ERIC Educational Resources Information Center

    Handscombe, Jean, Ed.; And Others

    The conference papers presented in this volume explore various aspects of a central question: how will computers be used in language teaching or, more broadly, who will be in control? The volume is divided into three sections: Critical Interactions, Promising Approaches, and Political Influences. Papers included within each of these categories are…

  3. Computer Poker

    ERIC Educational Resources Information Center

    Findler, Nicholas V.

    1978-01-01

    This familiar card game has interested mathematicians, economists, and psychologists as a model of decision-making in the real world. It is now serving as a vehicle for investigations in computer science. (Author/MA)

  4. "Discover New Worlds with Technology". Proceedings of the Annual College and University Computer Users Conference (37th, Miami, Florida, May 3-6, 1992).

    ERIC Educational Resources Information Center

    Miami-Dade Community Coll., FL.

    This book contains 37 papers on computer use in higher education originally presented at a May, 1992, conference of college and university computer users. Most of the papers describe programs or systems implemented at particular institutions and cover the following: systems for career planning, automating purchasing and financial commitments,…

  5. Science World Activities Book.

    ERIC Educational Resources Information Center

    Wisconsin Academy of Sciences, Arts and Letters, Madison.

    This document consists of three sections. Section I contains 19 activities developed by master teachers for the Science World '84 summer science program. These activities focus on studies involving airplane controls, trash bag kites, computers, meteorology, compass orienteering, soils, aquatic ecosystems, bogs, and others. Objectives, materials…

  6. Real World Graph Connectivity

    ERIC Educational Resources Information Center

    Lind, Joy; Narayan, Darren

    2009-01-01

    We present the topic of graph connectivity along with a famous theorem of Menger in the real-world setting of the national computer network infrastructure of "National LambdaRail". We include a set of exercises where students reinforce their understanding of graph connectivity by analysing the "National LambdaRail" network. Finally, we give…

  7. Science World Activities Book.

    ERIC Educational Resources Information Center

    Wisconsin Academy of Sciences, Arts and Letters, Madison.

    This document consists of three sections. Section I contains 19 activities developed by master teachers for the Science World '84 summer science program. These activities focus on studies involving airplane controls, trash bag kites, computers, meteorology, compass orienteering, soils, aquatic ecosystems, bogs, and others. Objectives, materials…

  8. Real World Graph Connectivity

    ERIC Educational Resources Information Center

    Lind, Joy; Narayan, Darren

    2009-01-01

    We present the topic of graph connectivity along with a famous theorem of Menger in the real-world setting of the national computer network infrastructure of "National LambdaRail". We include a set of exercises where students reinforce their understanding of graph connectivity by analysing the "National LambdaRail" network. Finally, we give…

  9. Physical World Hyperlinking: Can Computer-Based Instruction in a K-6 Educational Setting Be Easily Accessed through Tangible Tagged Objects

    ERIC Educational Resources Information Center

    Parton, Becky Sue; Hancock, Robert; Mihir, Mihir

    2010-01-01

    This paper examined multiple types of physical world hyperlinking hardware configurations for the purpose of determining an optimal reader/tag combination for K-6 student use. Both traditional barcode tags and two types of RFID (Radio Frequency Identification) tags were placed on tangible items. Students ranging from kindergarten to sixth grade…

  10. Physical World Hyperlinking: Can Computer-Based Instruction in a K-6 Educational Setting Be Easily Accessed through Tangible Tagged Objects

    ERIC Educational Resources Information Center

    Parton, Becky Sue; Hancock, Robert; Mihir, Mihir

    2010-01-01

    This paper examined multiple types of physical world hyperlinking hardware configurations for the purpose of determining an optimal reader/tag combination for K-6 student use. Both traditional barcode tags and two types of RFID (Radio Frequency Identification) tags were placed on tangible items. Students ranging from kindergarten to sixth grade…

  11. Superhabitable worlds.

    PubMed

    Heller, René; Armstrong, John

    2014-01-01

    To be habitable, a world (planet or moon) does not need to be located in the stellar habitable zone (HZ), and worlds in the HZ are not necessarily habitable. Here, we illustrate how tidal heating can render terrestrial or icy worlds habitable beyond the stellar HZ. Scientists have developed a language that neglects the possible existence of worlds that offer more benign environments to life than Earth does. We call these objects "superhabitable" and discuss in which contexts this term could be used, that is to say, which worlds tend to be more habitable than Earth. In an appendix, we show why the principle of mediocracy cannot be used to logically explain why Earth should be a particularly habitable planet or why other inhabited worlds should be Earth-like. Superhabitable worlds must be considered for future follow-up observations of signs of extraterrestrial life. Considering a range of physical effects, we conclude that they will tend to be slightly older and more massive than Earth and that their host stars will likely be K dwarfs. This makes Alpha Centauri B, which is a member of the closest stellar system to the Sun and is supposed to host an Earth-mass planet, an ideal target for searches for a superhabitable world.

  12. Proceedings of the 3rd World Congress on Integrated Computational Materials Engineering (ICME 2015). Held in Colorado Springs, CO on May 31-June 4, 2015

    DTIC Science & Technology

    2016-06-28

    Integrated Computational N000141512537 Materials Engineering (ICME 2015) 5b. GRANT NUMBER N000141512537 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d... Materials Society, Inc. REPORT NUMBER 184 Thorn Hill Road ICME2015 Warrendale, PA 15086 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10...Computational Materials Engineering (ICME) has received international attention due to its great potential to shorten product and process development

  13. Ring World

    NASA Image and Video Library

    2007-03-01

    Our robotic emissary, flying high above Saturn, captured this view of an alien copper-colored ring world. The overexposed planet has deliberately been removed to show the unlit rings alone, seen from an elevation of 60 degrees

  14. World Reaction to Virtual Space

    NASA Technical Reports Server (NTRS)

    1999-01-01

    DRaW Computing developed virtual reality software for the International Space Station. Open Worlds, as the software has been named, can be made to support Java scripting and virtual reality hardware devices. Open Worlds permits the use of VRML script nodes to add virtual reality capabilities to the user's applications.

  15. Democratizing Computer Science

    ERIC Educational Resources Information Center

    Margolis, Jane; Goode, Joanna; Ryoo, Jean J.

    2015-01-01

    Computer science programs are too often identified with a narrow stratum of the student population, often white or Asian boys who have access to computers at home. But because computers play such a huge role in our world today, all students can benefit from the study of computer science and the opportunity to build skills related to computing. The…

  16. Democratizing Computer Science

    ERIC Educational Resources Information Center

    Margolis, Jane; Goode, Joanna; Ryoo, Jean J.

    2015-01-01

    Computer science programs are too often identified with a narrow stratum of the student population, often white or Asian boys who have access to computers at home. But because computers play such a huge role in our world today, all students can benefit from the study of computer science and the opportunity to build skills related to computing. The…

  17. Computer graphics synthesis for inferring artist studio practice: an application to Diego Velázquez's Las Meninas[

    NASA Astrophysics Data System (ADS)

    Stork, David G.; Furuichi, Yasuo

    2009-02-01

    Diego Velázquez's Las meninas (1656) has been called by some art experts "the most important painting of the 17th century," "a theology of painting," and even "the world's greatest painting"; it has been the subject of intensive study. The work depicts a complex scene in the Alcázar palace of King Philip IV of Spain, and includes mirror reflections of the king and queen, apparently standing in place of the viewer, as well as the artist himself standing before an enormous canvas on an easel. Nevertheless, questions remain about the studio and the proper viewing configuration: Is the artist looking toward the perspectivally correct position of the viewer in the museum space (center of projection), outside the picture space? Does the perspectivally correct position correspond to the locations of the king and queen seen reflected in the mirror? Is the bright illumination on the king and queen (as revealed in the mirror) consistent with the lighting in the tableau itself? We addressed these questions in a new way: by building a full computer graphics model of the figures and tableau as well as the viewer's space outside the painting. In our full model, the painting itself is represented as a translucent window onto which the picture space is projected toward the center of projection, that is, the viewer. Our geometric and (new) lighting evidence confirm Janson's and Snyder's contention that the plane mirror on the back wall reflects the other side of the large painting depicted within the tableau, not the king and queen themselves in the studio. We believe our computer graphics synthesis of both the tableau within the painting and the viewer's space in the real world is the first of its kind to address such problems in the history of art.

  18. Our World?

    ERIC Educational Resources Information Center

    Samuelsson, Ingrid Pramling, Ed.

    Authored by individuals from five Nordic countries, this book focuses on questions about the child's right to live in and learn about an ecologically sustainable world. The first five chapters are theoretical in character, while the final six chapters are derived from work done by early childhood teachers together with children. The goal of the…

  19. World Report.

    ERIC Educational Resources Information Center

    Ceres, 1978

    1978-01-01

    Presents a report that deals with several topics from different parts of the world. A system for creating more meaningful maps, the recycling of organic wastes in agriculture in China, and producing pigs and poultry without pollution problems are among the topics presented. (HM)

  20. World Report.

    ERIC Educational Resources Information Center

    Ceres, 1978

    1978-01-01

    Presents a report that deals with several topics from different parts of the world. A system for creating more meaningful maps, the recycling of organic wastes in agriculture in China, and producing pigs and poultry without pollution problems are among the topics presented. (HM)

  1. An Exploration of Computer Game-Based Instruction in the “World History” Class in Secondary Education: A Comparative Study in China

    PubMed Central

    Yu, Zhonggen; Yu, Wei Hua; Fan, Xiaohui; Wang, Xiao

    2014-01-01

    So far, many studies on educational games have been carried out in America and Europe. Very few related empirical studies, however, have been conducted in China. This study, combining both quantitative with qualitative research methods, possibly compensated for this regret. The study compared data collected from two randomly selected classes (out of 13 classes) under computer game-based instruction (CGBI) and non-computer game-based instruction (NCGBI), respectively, in a senior high school located in Nanjing, Capital of Jiangsu Province, in China. The participants were 103 students, composed of 52 boys and 51 girls (aged 17-18 years old). The following conclusion was reached: (1) participants under CGBI obtained significantly greater learning achievement than those under NCGBI; (2) participants were significantly more motivated by CGBI compared with NCGBI; (3) there were no significant differences in learning achievement between boys and girls; although (4) boys were significantly more motivated by CGBI than girls. Both disadvantages and advantages were discussed, together with directions for future research. PMID:24816635

  2. An exploration of computer game-based instruction in the "world history" class in secondary education: a comparative study in China.

    PubMed

    Yu, Zhonggen; Yu, Wei Hua; Fan, Xiaohui; Wang, Xiao

    2014-01-01

    So far, many studies on educational games have been carried out in America and Europe. Very few related empirical studies, however, have been conducted in China. This study, combining both quantitative with qualitative research methods, possibly compensated for this regret. The study compared data collected from two randomly selected classes (out of 13 classes) under computer game-based instruction (CGBI) and non-computer game-based instruction (NCGBI), respectively, in a senior high school located in Nanjing, Capital of Jiangsu Province, in China. The participants were 103 students, composed of 52 boys and 51 girls (aged 17-18 years old). The following conclusion was reached: (1) participants under CGBI obtained significantly greater learning achievement than those under NCGBI; (2) participants were significantly more motivated by CGBI compared with NCGBI; (3) there were no significant differences in learning achievement between boys and girls; although (4) boys were significantly more motivated by CGBI than girls. Both disadvantages and advantages were discussed, together with directions for future research.

  3. 17th DOE nuclear air cleaning conference: proceedings. Volume 2

    SciTech Connect

    First, M.W.

    1983-02-01

    Volume 2 contains papers presented at the following sessions: adsorption; noble gas treatment; personnel education and training; filtration and filter testing; measurement and instrumentation; air cleaning equipment response to accident related stress; containment venting air cleaning; and an open end session. Twenty-eight papers were indexed separately for inclusion in the Energy Data Base. Ten papers had been entered earlier.

  4. 17th Environmental Quality Index: Troubling Times with Toxics.

    ERIC Educational Resources Information Center

    National Wildlife, 1986

    1986-01-01

    Presents a subjective analysis of the status of United States' natural resources, reviewing 1985's key environmental events, problems, and successes. Reports current conditions and/or dilemmas concerning wildlife, air, water, energy, forests, and soils. Provides both a public rating of the quality of life and a priority ranking of environmental…

  5. The 17th Symposium on Biotechnology for Fuels and Chemicals

    NASA Astrophysics Data System (ADS)

    This volume contains the abstracts of oral and poster presentations made at the Seventeenth Symposium on Biotechnology for Fuels and Chemicals. Session titles include Thermal, Chemical, and Biological Processing; Applied Biological Research; Bioprocessing Research; Special Topics Discussion Groups; Process Economics and Commercialization; and Environmental Biotechnology.

  6. Proceedings of the 17th biennial southern silvicultural research conference

    Treesearch

    A. Gordon Holley; Kristina F. Connor; James D. Haywood

    2015-01-01

    A range of issues affecting southern forests are addressed in 108 papers or extended abstracts. Papers are grouped in 13 sections that cover the topics of hardwood regeneration, best management practices for stream crossings, pine regeneration and genetics, fire effects, eco-physiology, forest nutrition, vegetation management, forest threats, biomass, biometrics,...

  7. Final Report: 17th international Symposium on Plant Lipids

    SciTech Connect

    Christoph Benning

    2007-03-07

    This meeting covered several emerging areas in the plant lipid field such as the biosynthesis of cuticle components, interorganelle lipid trafficking, the regulation of lipid homeostasis, and the utilization of algal models. Stimulating new insights were provided not only based on research reports based on plant models, but also due to several excellent talks by experts from the yeast field.

  8. Aspects of Negative Numbers in the Early 17th Century.

    ERIC Educational Resources Information Center

    Thomaidis, Yannis

    1993-01-01

    Explores two different types of problems through which negative numbers started being used systematically in mathematics. The first problem deals with the correspondence between the terms of an arithmetical and a geometrical progression; the second deals with the application of algebraic syntactical rules in the theory of equations. (PR)

  9. IL-17/Th17 Pathway Is Activated in Acne Lesions

    PubMed Central

    Kelhälä, Hanna-Leena; Palatsi, Riitta; Fyhrquist, Nanna; Lehtimäki, Sari; Väyrynen, Juha P.; Kallioinen, Matti; Kubin, Minna E.; Greco, Dario; Tasanen, Kaisa; Alenius, Harri; Bertino, Beatrice; Carlavan, Isabelle; Mehul, Bruno; Déret, Sophie; Reiniche, Pascale; Martel, Philippe; Marty, Carine; Blume-Peytavi, Ulrike; Voegel, Johannes J.; Lauerma, Antti

    2014-01-01

    The mechanisms of inflammation in acne are currently subject of intense investigation. This study focused on the activation of adaptive and innate immunity in clinically early visible inflamed acne lesions and was performed in two independent patient populations. Biopsies were collected from lesional and non-lesional skin of acne patients. Using Affymetrix Genechips, we observed significant elevation of the signature cytokines of the Th17 lineage in acne lesions compared to non-lesional skin. The increased expression of IL-17 was confirmed at the RNA and also protein level with real-time PCR (RT-PCR) and Luminex technology. Cytokines involved in Th17 lineage differentiation (IL-1β, IL-6, TGF-β, IL23p19) were remarkably induced at the RNA level. In addition, proinflammatory cytokines and chemokines (TNF-α, IL-8, CSF2 and CCL20), Th1 markers (IL12p40, CXCR3, T-bet, IFN-γ), T regulatory cell markers (Foxp3, IL-10, TGF-β) and IL-17 related antimicrobial peptides (S100A7, S100A9, lipocalin, hBD2, hBD3, hCAP18) were induced. Importantly, immunohistochemistry revealed significantly increased numbers of IL-17A positive T cells and CD83 dendritic cells in the acne lesions. In summary our results demonstrate the presence of IL-17A positive T cells and the activation of Th17-related cytokines in acne lesions, indicating that the Th17 pathway is activated and may play a pivotal role in the disease process, possibly offering new targets of therapy. PMID:25153527

  10. Athanasius Kircher: The 17th Century Science at the Crossroads

    NASA Astrophysics Data System (ADS)

    Buonanno, R.

    2011-06-01

    Athanasius Kircher, who entered the Society of Jesus in 1628, is a peculiar scientist who is in love with everything he sees and with everything he thinks he sees. He is a non-Galilean scientist whose general attitude is not obscurantism but rather a defense of established faith. He arrives in Rome in the fall of 1633 when he is in his thirties. Even if at the epoch Kircher has already written some of his many books, it is amazing that Galileo does not even quote him in the letters he will wrote in the rest of his life. In spite of having stridden along a minor scientific path, opposite of that shown by Galileo, it is nonetheless surprising to find out that Athanasius Kircher was gifted with remarkable intuition, and was in some cases even decades in advance with respect to the age he lived in.

  11. 17th Environmental Quality Index: Troubling Times with Toxics.

    ERIC Educational Resources Information Center

    National Wildlife, 1986

    1986-01-01

    Presents a subjective analysis of the status of United States' natural resources, reviewing 1985's key environmental events, problems, and successes. Reports current conditions and/or dilemmas concerning wildlife, air, water, energy, forests, and soils. Provides both a public rating of the quality of life and a priority ranking of environmental…

  12. Light on! Real world evaluation of a P300-based brain-computer interface (BCI) for environment control in a smart home.

    PubMed

    Carabalona, Roberta; Grossi, Ferdinando; Tessadri, Adam; Castiglioni, Paolo; Caracciolo, Antonio; de Munari, Ilaria

    2012-01-01

    Brain-computer interface (BCI) systems aim to enable interaction with other people and the environment without muscular activation by the exploitation of changes in brain signals due to the execution of cognitive tasks. In this context, the visual P300 potential appears suited to control smart homes through BCI spellers. The aim of this work is to evaluate whether the widely used character-speller is more sustainable than an icon-based one, designed to operate smart home environment or to communicate moods and needs. Nine subjects with neurodegenerative diseases and no BCI experience used both speller types in a real smart home environment. User experience during BCI tasks was evaluated recording concurrent physiological signals. Usability was assessed for each speller type immediately after use. Classification accuracy was lower for the icon-speller, which was also more attention demanding. However, in subjective evaluations, the effect of a real feedback partially counterbalanced the difficulty in BCI use. Since inclusive BCIs require to consider interface sustainability, we evaluated different ergonomic aspects of the interaction of disabled users with a character-speller (goal: word spelling) and an icon-speller (goal: operating a real smart home). We found the first one as more sustainable in terms of accuracy and cognitive effort.

  13. A linguistic analysis of grooming strategies of online child sex offenders: Implications for our understanding of predatory sexual behavior in an increasingly computer-mediated world.

    PubMed

    Black, Pamela J; Wollis, Melissa; Woodworth, Michael; Hancock, Jeffrey T

    2015-06-01

    There is a large body of evidence to suggest that child sex offenders engage in grooming to facilitate victimization. It has been speculated that this step-by-step grooming process is also used by offenders who access their underage victims online; however, little research has been done to examine whether there are unique aspects of computer-mediated communication that impact the traditional face-to-face grooming process. This study considered the similarities and differences in the grooming process in online environments by analyzing the language used by online offenders when communicating with their victims. The transcripts of 44 convicted online offenders were analyzed to assess a proposed theory of the online grooming process (O'Connell, 2003). Using a stage-based approach, computerized text analysis examined the types of language used in each stage of the offender-victim interaction. The transcripts also were content analyzed to examine the frequency of specific techniques known to be employed by both face-to-face and online offenders, such as flattery. Results reveal that while some evidence of the strategies used by offenders throughout the grooming process are present in online environments, the order and timing of these stages appear to be different. The types (and potential underlying pattern) of strategies used in online grooming support the development of a revised model for grooming in online environments. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Decreased length of stay after addition of healthcare provider in emergency department triage: a comparison between computer-simulated and real-world interventions

    PubMed Central

    Al-Roubaie, Abdul Rahim; Goldlust, Eric Jonathan

    2013-01-01

    Objective (1) To determine the effects of adding a provider in triage on average length of stay (LOS) and proportion of patients with >6 h LOS. (2) To assess the accuracy of computer simulation in predicting the magnitude of such effects on these metrics. Methods A group-level quasi-experimental trial comparing the St. Louis Veterans Affairs Medical Center emergency department (1) before intervention, (2) after institution of provider in triage, and discrete event simulation (DES) models of similar (3) ‘before’ and (4) ‘after’ conditions. The outcome measures were daily mean LOS and percentage of patients with LOS >6 h. Results The DES-modelled intervention predicted a decrease in the %6-hour LOS from 19.0% to 13.1%, and a drop in the daily mean LOS from 249 to 200 min (p<0.0001). Following (actual) intervention, the number of patients with LOS >6 h decreased from 19.9% to 14.3% (p<0.0001), with the daily mean LOS decreasing from 247 to 210 min (p<0.0001). Conclusion Physician and mid-level provider coverage at triage significantly reduced emergency department LOS in this setting. DES accurately predicted the magnitude of this effect. These results suggest further work in the generalisability of triage providers and in the utility of DES for predicting quantitative effects of process changes. PMID:22398851

  15. Small-world networks

    NASA Astrophysics Data System (ADS)

    Strogatz, Steven

    Everyone is familiar with the small-world phenomenon: soon after meeting a stranger, we are often suprised to discover that we have a mutual friend, or that we are somehow linked by a short chain of friends. In this talk, I'll present evidence that the small-world phenomenon is more than a curiosity of social networks — it is actually a general property of large, sparse networks whose topology is neither completely regular nor completely random. To check this idea, Duncan Watts and I have analyzed three networks of scientific interest: the neural network of the nematode worm C. elegans, the electrical power grid of the western United States, and the collaboration graph of actors in feature films. All three are small worlds, in the sense that the average number of "handshakes" separating any two members is extremely small (close to the theoretical lower limit set by a random graph). Yet at the same time, all three networks exhibit much more local clustering than a random net, demonstrating that they are not random. I'll also discuss a class of model networks that interpolate between regular lattices and random graphs. Previous theoretical research on complex systems in a wide range of disciplines has focused almost exclusively on networks that are either regular or random. Real networks often lie somewhere in between. Our mathematical model shows that networks in this middle ground tend to exhibit the small-world phenomenon, thanks to the presence of a few long-range edges that link parts of the graph that would otherwise be far apart. Furthermore, we find that when various dynamical systems are coupled in a small-world fashion, they exhibit much greater propagation speed, computational power, and synchronizability than their locally connected, regular counterparts. We explore the implications of these results for simple models of disease spreading, global computation in cellular automata, and collective locking of biological oscillators.

  16. Hello Worlds

    ERIC Educational Resources Information Center

    Kirschenbaum, Matthew

    2009-01-01

    The author advocates that humanities scholars should seek and study programming languages. He believes that, increasingly, an appreciation of how complex ideas can be imagined and expressed as a set of formal procedures--rules, models, algorithms--in the virtual space of a computer will be an essential element of a humanities education. Students…

  17. Hello Worlds

    ERIC Educational Resources Information Center

    Kirschenbaum, Matthew

    2009-01-01

    The author advocates that humanities scholars should seek and study programming languages. He believes that, increasingly, an appreciation of how complex ideas can be imagined and expressed as a set of formal procedures--rules, models, algorithms--in the virtual space of a computer will be an essential element of a humanities education. Students…

  18. Neal Lane: Science in a Flat World

    ScienceCinema

    Neal Lane

    2016-07-12

    Lane discusses the changes that have taken place in the world since World War II that have made it "flatter," referring to Thomas L. Friedman's book, The World is Flat. Friedman's main premise is that inexpensive telecommunications is bringing about unhampered international competition, the demise of economic stability, and a trend toward outsourcing services, such as computer programming, engineering and science research.

  19. Neal Lane: Science in a Flat World

    SciTech Connect

    Neal Lane

    2006-09-12

    Lane discusses the changes that have taken place in the world since World War II that have made it "flatter," referring to Thomas L. Friedman's book, The World is Flat. Friedman's main premise is that inexpensive telecommunications is bringing about unhampered international competition, the demise of economic stability, and a trend toward outsourcing services, such as computer programming, engineering and science research.

  20. Pervasive Computing Goes to School

    ERIC Educational Resources Information Center

    Plymale, William O.

    2005-01-01

    In 1991 Mark Weiser introduced the idea of ubiquitous computing: a world in which computers and associated technologies become invisible, and thus indistinguishable from everyday life. This invisible computing is accomplished by means of "embodied virtuality," the process of drawing computers into the physical world. Weiser proposed that…

  1. Pervasive Computing Goes to School

    ERIC Educational Resources Information Center

    Plymale, William O.

    2005-01-01

    In 1991 Mark Weiser introduced the idea of ubiquitous computing: a world in which computers and associated technologies become invisible, and thus indistinguishable from everyday life. This invisible computing is accomplished by means of "embodied virtuality," the process of drawing computers into the physical world. Weiser proposed that…

  2. Incident Management Systems Evaluation and Usability Assessment

    DTIC Science & Technology

    2011-06-01

    unpleasant and potentially unsuccessful experience. SOFTWARE USABILITY Definition Usability consultant Jakob Nielson [4] suggests that the usability...Bevan, N., User Requirements Analysis, Proceedings of IFIP 17th World Computer Congress, Montreal, Canada, August 2002. 4. Nielsen , J., Usability 101

  3. What is a Computer?

    ERIC Educational Resources Information Center

    Ball, Marion J.

    This colorfully illustrated book is designed to introduce elementary school students to the world of computers. Computers, their component parts and their capabilities are personified using full page sketches and color drawings. The differences between analog and digital computers are given as is a short history of computer use and development.…

  4. Typical worlds

    NASA Astrophysics Data System (ADS)

    Barrett, Jeffrey A.

    2017-05-01

    Hugh Everett III presented pure wave mechanics, sometimes referred to as the many-worlds interpretation, as a solution to the quantum measurement problem. While pure wave mechanics is an objectively deterministic physical theory with no probabilities, Everett sought to show how the theory might be understood as making the standard quantum statistical predictions as appearances to observers who were themselves described by the theory. We will consider his argument and how it depends on a particular notion of branch typicality. We will also consider responses to Everett and the relationship between typicality and probability. The suggestion will be that pure wave mechanics requires a number of significant auxiliary assumptions in order to make anything like the standard quantum predictions.

  5. Shell worlds

    NASA Astrophysics Data System (ADS)

    Roy, Kenneth I.; Kennedy, Robert G., III; Fields, David E.

    2013-02-01

    The traditional concept of terraforming assumes ready availability of candidate planets with acceptable qualities: orbiting a star in its "Goldilocks zone", liquid water, enough mass, years longer than days, magnetic field, etc. But even stipulating affordable interstellar travel, we still might never find a good candidate elsewhere. Whatever we found likely would require centuries of heavy terraforming, just as Mars or Venus would here. Our increasing appreciation of the ubiquity of life suggests that any terra nova would already possess it. We would then face the dilemma of introducing alien life forms (us, our microbes) into another living world. Instead, we propose a novel method to create habitable environments for humanity by enclosing airless, sterile, otherwise useless planets, moons, and even large asteroids within engineered shells, which avoids the conundrum. These shells are subject to two opposing internal stresses: compression due to the primary's gravity, and tension from atmospheric pressure contained inside. By careful design, these two cancel each other resulting in zero net shell stress. Beneath the shell an Earth-like environment could be created similar in almost all respects to that of Home, except for gravity, regardless of the distance to the sun or other star. Englobing a small planet, moon, or even a dwarf planet like Ceres, would require astronomical amounts of material (quadrillions of tons) and energy, plus a great deal of time. It would be a quantum leap in difficulty over building Dyson Dots or industrializing our solar system, perhaps comparable to a mission across interstellar space with a living crew within their lifetime. But when accomplished, these constructs would be complete (albeit small) worlds, not merely large habitats. They could be stable across historic timescales, possibly geologic. Each would contain a full, self-sustaining ecology, which might evolve in curious directions over time. This has interesting implications

  6. An Interactive Immersive Serious Game Application for Kunyu Quantu World Map

    NASA Astrophysics Data System (ADS)

    Peng, S.-T.; Hsu, S.-Y.; Hsieh, K.-C.

    2015-08-01

    In recent years, more and more digital technologies and innovative concepts are applied on museum education. One of the concepts applied is "Serious game." Serious game is not designed for entertainment purpose but allows users to learn real world's cultural and educational knowledge in the virtual world through game-experiencing. Technologies applied on serious game are identical to those applied on entertainment game. Nowadays, the interactive technology applications considering users' movement and gestures in physical spaces are developing rapidly, which are extensively used in entertainment games, such as Kinect-based games. The ability to explore space via Kinect-based games can be incorporated into the design of serious game. The ancient world map, Kunyu Quantu, from the collection of the National Palace Museum is therefore applied in serious game development. In general, the ancient world map does not only provide geological information, but also contains museum knowledge. This particular ancient world map is an excellent content applied in games as teaching material. In the 17th century, it was first used by a missionary as a medium to teach the Kangxi Emperor of the latest geologic and scientific spirits from the West. On this map, it also includes written biological knowledge and climate knowledge. Therefore, this research aims to present the design of the interactive and immersive serious game based installation that developed from the rich content of the Kunyu Quantu World Map, and to analyse visitor's experience in terms of real world's cultural knowledge learning and interactive responses.

  7. Visualizing the Microscopic World.

    PubMed

    Cerqueira, Nuno M F S A; Fernandes, Pedro A; Ramos, Maria João

    2017-08-09

    Visualization can be a motivating way of teaching students about the microscopic world. This can become even more exciting if the information is based on accurate computational results rather than on crude approximations that eventually might create unreal alternative perceptions. Here, we report on a VMD plug-in, named vmdMagazine, which can turn computational simulations into stunning high-impact video presentations, suitable for classes/lectures and even conferences. The software will help students/audience to understand atoms and molecules better and learn to like them. The present paper is meant to give a general idea of the software's potential, showing how it works and how it can be used for educational purposes. The software is freely available at: http://www.fc.up.pt/PortoBioComp/database/doku.php?id=vmdmagazine .

  8. Application of matrix-assisted laser desorption and ionization time of flight mass spectrometry to the study of the proteinaceous binders in paint: blue paint composition in the series "The Life of Virgin" by Alonso Cano (17th century) as a case study.

    PubMed

    Romero-Pastor, Julia; Natalia Navas, Natalia Navas; Rodríguez-Simón, Luís; Lario-Simón, Antonio; Kuckova, Stepanka; Manzano, Eloísa

    2015-01-01

    The identification of proteinaceous materials in paint constituents provides very valuable information regarding the techniques used by the painter and the most suitable procedures for conserving and restoring their works. Although the analysis of proteinaceous materials is nowadays a common task when dealing with works of art, the reliable detection and identification of protein traces is still complicated, particularly when very small samples can be taken that may contain a mixture of different organic materials (oils, waxes, resins, gums etc.). We therefore proposed a proteomic approach to investigate protein materials in paintings at trace levels in order to obtain a better understanding of the painter's technique. After trypsin digestion of the paint samples, mass spectra were obtained by matrix-assisted laser desorption and ionization time of flight mass spectrometry (MALDI-TOF-MS) and they were compared with the Mascot database and with theoretical digested proteins. This study contributes to the knowledge about the technique used by Alonso Cano (Granada, Spain, 1601-1667), one of the most original and brilliant artists from the Spanish Golden Age (17th century), in the series called the Life of the Virgin (six paintings), part of the iconographic program about the life of the Virgin Mary, nowadays seen in the main chapel of Granada Cathedral. The objective of the present study was to test the use of proteinaceous material, mainly egg yolk, in the paint used by Cano, as suggested in previous research, although this would have been unusual at that time when most artists used oil paints. Based on the results of the analysis here presented, the use of protein in the binding media can most likely be excluded.

  9. Virtual Worlds for Virtual Organizing

    NASA Astrophysics Data System (ADS)

    Rhoten, Diana; Lutters, Wayne

    The members and resources of a virtual organization are dispersed across time and space, yet they function as a coherent entity through the use of technologies, networks, and alliances. As virtual organizations proliferate and become increasingly important in society, many may exploit the technical architecture s of virtual worlds, which are the confluence of computer-mediated communication, telepresence, and virtual reality originally created for gaming. A brief socio-technical history describes their early origins and the waves of progress followed by stasis that brought us to the current period of renewed enthusiasm. Examination of contemporary examples demonstrates how three genres of virtual worlds have enabled new arenas for virtual organizing: developer-defined closed worlds, user-modifiable quasi-open worlds, and user-generated open worlds. Among expected future trends are an increase in collaboration born virtually rather than imported from existing organizations, a tension between high-fidelity recreations of the physical world and hyper-stylized imaginations of fantasy worlds, and the growth of specialized worlds optimized for particular sectors, companies, or cultures.

  10. A World View Sampler.

    ERIC Educational Resources Information Center

    Willard, Timothy; And Others

    1984-01-01

    An overview of topics discussed at the World View '84 conference, sponsored by the World Future Society, is provided. Topics include technology, the economy, the Third World, the environment, world order, and outer space. (RM)

  11. Why Teach the World English?

    ERIC Educational Resources Information Center

    Kaplan, Robert B.

    This paper contends that the World War II settlements, the birth of the United Nations, the invention of the computer, and the geometric growth of science and technology, all occurring accidentally at the same time, created the conditions which made English an important language. The paper notes the financial incentives in servicing international…

  12. Evolutionary Computing

    SciTech Connect

    Patton, Robert M; Cui, Xiaohui; Jiao, Yu; Potok, Thomas E

    2008-01-01

    The rate at which information overwhelms humans is significantly more than the rate at which humans have learned to process, analyze, and leverage this information. To overcome this challenge, new methods of computing must be formulated, and scientist and engineers have looked to nature for inspiration in developing these new methods. Consequently, evolutionary computing has emerged as new paradigm for computing, and has rapidly demonstrated its ability to solve real-world problems where traditional techniques have failed. This field of work has now become quite broad and encompasses areas ranging from artificial life to neural networks. This chapter focuses specifically on two sub-areas of nature-inspired computing: Evolutionary Algorithms and Swarm Intelligence.

  13. LHC Computing

    ScienceCinema

    Lincoln, Don

    2016-07-12

    The LHC is the world’s highest energy particle accelerator and scientists use it to record an unprecedented amount of data. This data is recorded in electronic format and it requires an enormous computational infrastructure to convert the raw data into conclusions about the fundamental rules that govern matter. In this video, Fermilab’s Dr. Don Lincoln gives us a sense of just how much data is involved and the incredible computer resources that makes it all possible.

  14. Computer viruses

    NASA Technical Reports Server (NTRS)

    Denning, Peter J.

    1988-01-01

    The worm, Trojan horse, bacterium, and virus are destructive programs that attack information stored in a computer's memory. Virus programs, which propagate by incorporating copies of themselves into other programs, are a growing menace in the late-1980s world of unprotected, networked workstations and personal computers. Limited immunity is offered by memory protection hardware, digitally authenticated object programs,and antibody programs that kill specific viruses. Additional immunity can be gained from the practice of digital hygiene, primarily the refusal to use software from untrusted sources. Full immunity requires attention in a social dimension, the accountability of programmers.

  15. Computer vision

    SciTech Connect

    Not Available

    1982-01-01

    This paper discusses material from areas such as artificial intelligence, psychology, computer graphics, and image processing. The intent is to assemble a selection of this material in a form that will serve both as a senior/graduate-level academic text and as a useful reference to those building vision systems. This book has a strong artificial intelligence flavour, emphasising the belief that both the intrinsic image information and the internal model of the world are important in successful vision systems. The book is organised into four parts, based on descriptions of objects at four different levels of abstraction. These are: generalised images-images and image-like entities; segmented images-images organised into subimages that are likely to correspond to interesting objects; geometric structures-quantitative models of image and world structures; relational structures-complex symbolic descriptions of image and world structures. The book contains author and subject indexes.

  16. Chippy's Computer Numbers.

    ERIC Educational Resources Information Center

    Girard, Suzanne; Willing, Kathlene R.

    Intended for young children just becoming familiar with computers, this counting book introduces and reinforces new computer vocabulary and concepts. The numbers, from one to twelve, are presented along with words and illustrations from the world of computers, allowing for different activities in which children can count or match and name the…

  17. Ubiquitous Complete in a Web 2.0 World

    ERIC Educational Resources Information Center

    Bull, Glen; Ferster, Bill

    2006-01-01

    In the third wave of computing, people will interact with multiple computers in multiple ways in every setting. The value of ubiquitous computing is enhanced and reinforced by another trend: the transition to a Web 2.0 world. In a Web 2.0 world, applications and data reside on the Web itself. Schools are not yet approaching a ratio of one…

  18. Deploying Embodied AI into Virtual Worlds

    NASA Astrophysics Data System (ADS)

    Burden, David J. H.

    The last two years have seen the start of commercial activity within virtual worlds. Unlike computer games where Non-Player-Character avatars are common, in most virtual worlds they are the exception — and until recently in Second Life they were non-existent. However there is real commercial scope for Als in these worlds — in roles from virtual sales staff and tutors to personal assistants. Deploying an embodied AI into a virtual world offers a unique opportunity to evaluate embodied Als, and to develop them within an environment where human and computer are on almost equal terms. This paper presents an architecture being used for the deployment of chatbot driven avatars within the Second Life virtual world, looks at the challenges of deploying an AI within such a virtual world, the possible implications for the Turing Test, and identifies research directions for the future.

  19. World Energy Projection System Plus Model Documentation: Industrial Model

    EIA Publications

    2016-01-01

    This report documents the objectives, analytical approach and development of the World Energy Projection System Plus (WEPS ) World Industrial Model (WIM). It also catalogues and describes critical assumptions, computational methodology, parameter estimation techniques, and model source code.

  20. World Energy Projection System Plus Model Documentation: Electricity Model

    EIA Publications

    2017-01-01

    This report documents the objectives, analytical approach and development of the World Energy Projection System Plus (WEPS ) World Electricity Model. It also catalogues and describes critical assumptions, computational methodology, parameter estimation techniques, and model source code.

  1. World Energy Projection System Plus Model Documentation: Industrial Module

    EIA Publications

    2016-01-01

    This report documents the objectives, analytical approach and development of the World Energy Projection System Plus (WEPS ) World Industrial Model (WIM). It also catalogues and describes critical assumptions, computational methodology, parameter estimation techniques, and model source code.

  2. NASA TileWorld Simulator Program

    NASA Technical Reports Server (NTRS)

    Philips, Andrew; Bresina, John; Drummond, Mark

    1993-01-01

    NASA TileWorld (NTW) computer program formulated to further research on planning, scheduling, and control problems. Designed to focus on three particular attributes of real-world problems: exogenous events, uncertain outcomes of actions, and metric time. Written specifically for use by NASA, NTW modified easily to act as software base for other simulated environments. Written in Allegro Common Lisp for Sun-3-(TM) and Sun-4-series(TM) computers running SunOS(TM).

  3. Introduction to the world wide web.

    PubMed

    Downes, P K

    2007-05-12

    The World Wide Web used to be nicknamed the 'World Wide Wait'. Now, thanks to high speed broadband connections, browsing the web has become a much more enjoyable and productive activity. Computers need to know where web pages are stored on the Internet, in just the same way as we need to know where someone lives in order to post them a letter. This section explains how the World Wide Web works and how web pages can be viewed using a web browser.

  4. Quantum computers.

    PubMed

    Ladd, T D; Jelezko, F; Laflamme, R; Nakamura, Y; Monroe, C; O'Brien, J L

    2010-03-04

    Over the past several decades, quantum information science has emerged to seek answers to the question: can we gain some advantage by storing, transmitting and processing information encoded in systems that exhibit unique quantum properties? Today it is understood that the answer is yes, and many research groups around the world are working towards the highly ambitious technological goal of building a quantum computer, which would dramatically improve computational power for particular tasks. A number of physical systems, spanning much of modern physics, are being developed for quantum computation. However, it remains unclear which technology, if any, will ultimately prove successful. Here we describe the latest developments for each of the leading approaches and explain the major challenges for the future.

  5. Virtual Labs and Virtual Worlds

    NASA Astrophysics Data System (ADS)

    Boehler, Ted

    2006-12-01

    Virtual Labs and Virtual Worlds Coastline Community College has under development several virtual lab simulations and activities that range from biology, to language labs, to virtual discussion environments. Imagine a virtual world that students enter online, by logging onto their computer from home or anywhere they have web access. Upon entering this world they select a personalized identity represented by a digitized character (avatar) that can freely move about, interact with the environment, and communicate with other characters. In these virtual worlds, buildings, gathering places, conference rooms, labs, science rooms, and a variety of other “real world” elements are evident. When characters move about and encounter other people (players) they may freely communicate. They can examine things, manipulate objects, read signs, watch video clips, hear sounds, and jump to other locations. Goals of critical thinking, social interaction, peer collaboration, group support, and enhanced learning can be achieved in surprising new ways with this innovative approach to peer-to-peer communication in a virtual discussion world. In this presentation, short demos will be given of several online learning environments including a virtual biology lab, a marine science module, a Spanish lab, and a virtual discussion world. Coastline College has been a leader in the development of distance learning and media-based education for nearly 30 years and currently offers courses through PDA, Internet, DVD, CD-ROM, TV, and Videoconferencing technologies. Its distance learning program serves over 20,000 students every year. sponsor Jerry Meisner

  6. World reconstruction in psychotherapy.

    PubMed

    Bergner, Raymond M

    2005-01-01

    The purpose of this article is to articulate how we, as psychotherapists, can transform the worlds of our clients. In part one of the article, the concept of "world," the dynamics of how worlds operate, and the clinically relevant notions of "problematic worlds" and "impossible worlds" are explicated. In part two, therapeutic recommendations for helping clients to reconstruct their worlds are presented, with special emphasis on problems of grief post-traumatic stress disorder, and the experience of meaninglessness.

  7. COMPUTATIONAL TOXICOLOGY-WHERE IS THE DATA? ...

    EPA Pesticide Factsheets

    This talk will briefly describe the state of the data world for computational toxicology and one approach to improve the situation, called ACToR (Aggregated Computational Toxicology Resource). This talk will briefly describe the state of the data world for computational toxicology and one approach to improve the situation, called ACToR (Aggregated Computational Toxicology Resource).

  8. Suicidal behaviour in the ancient Greek and Roman world.

    PubMed

    Lykouras, L; Poulakou-Rebelakou, E; Tsiamis, C; Ploumpidis, D

    2013-12-01

    We attempt to present and analyze suicidal behaviour in the ancient Greek and Roman world. Drawing information from ancient Greek and Latin sources (History, Philosophy, Medicine, Literature, Visual Arts) we aim to point out psychological and social aspects of suicidal behaviour in antiquity. The shocking exposition of suicides reveals the zeitgeist of each era and illustrates the prevailing concepts. Social and legal reactions appear ambivalent, as they can oscillate from acceptance and interpretation of the act to punishment. In the history of these attitudes, we can observe continuities and breaches, reserving a special place in cases of mental disease. The delayed emergence of a generally accepted term for the voluntary exit from life (the term suicidium established during the 17th century), is connected to reactions triggered by the act of suicide than to the frequency and the extent of the phenomenon. The social environment of the person, who voluntary ends his life usually dictates the behaviour and historical evidence confirms the phenomenon. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Scientific Grid computing.

    PubMed

    Coveney, Peter V

    2005-08-15

    We introduce a definition of Grid computing which is adhered to throughout this Theme Issue. We compare the evolution of the World Wide Web with current aspirations for Grid computing and indicate areas that need further research and development before a generally usable Grid infrastructure becomes available. We discuss work that has been done in order to make scientific Grid computing a viable proposition, including the building of Grids, middleware developments, computational steering and visualization. We review science that has been enabled by contemporary computational Grids, and associated progress made through the widening availability of high performance computing.

  10. Virtual Laboratories and Virtual Worlds

    NASA Astrophysics Data System (ADS)

    Hut, Piet

    2008-05-01

    Since we cannot put stars in a laboratory, astrophysicists had to wait till the invention of computers before becoming laboratory scientists. For half a century now, we have been conducting experiments in our virtual laboratories. However, we ourselves have remained behind the keyboard, with the screen of the monitor separating us from the world we are simulating. Recently, 3D on-line technology, developed first for games but now deployed in virtual worlds like Second Life, is beginning to make it possible for astrophysicists to enter their virtual labs themselves, in virtual form as avatars. This has several advantages, from new possibilities to explore the results of the simulations to a shared presence in a virtual lab with remote collaborators on different continents. I will report my experiences with the use of Qwaq Forums, a virtual world developed by a new company (see http://www.qwaq.com).

  11. Computational mechanics

    SciTech Connect

    Goudreau, G.L.

    1993-03-01

    The Computational Mechanics thrust area sponsors research into the underlying solid, structural and fluid mechanics and heat transfer necessary for the development of state-of-the-art general purpose computational software. The scale of computational capability spans office workstations, departmental computer servers, and Cray-class supercomputers. The DYNA, NIKE, and TOPAZ codes have achieved world fame through our broad collaborators program, in addition to their strong support of on-going Lawrence Livermore National Laboratory (LLNL) programs. Several technology transfer initiatives have been based on these established codes, teaming LLNL analysts and researchers with counterparts in industry, extending code capability to specific industrial interests of casting, metalforming, and automobile crash dynamics. The next-generation solid/structural mechanics code, ParaDyn, is targeted toward massively parallel computers, which will extend performance from gigaflop to teraflop power. Our work for FY-92 is described in the following eight articles: (1) Solution Strategies: New Approaches for Strongly Nonlinear Quasistatic Problems Using DYNA3D; (2) Enhanced Enforcement of Mechanical Contact: The Method of Augmented Lagrangians; (3) ParaDyn: New Generation Solid/Structural Mechanics Codes for Massively Parallel Processors; (4) Composite Damage Modeling; (5) HYDRA: A Parallel/Vector Flow Solver for Three-Dimensional, Transient, Incompressible Viscous How; (6) Development and Testing of the TRIM3D Radiation Heat Transfer Code; (7) A Methodology for Calculating the Seismic Response of Critical Structures; and (8) Reinforced Concrete Damage Modeling.

  12. Computer vision

    NASA Technical Reports Server (NTRS)

    Gennery, D.; Cunningham, R.; Saund, E.; High, J.; Ruoff, C.

    1981-01-01

    The field of computer vision is surveyed and assessed, key research issues are identified, and possibilities for a future vision system are discussed. The problems of descriptions of two and three dimensional worlds are discussed. The representation of such features as texture, edges, curves, and corners are detailed. Recognition methods are described in which cross correlation coefficients are maximized or numerical values for a set of features are measured. Object tracking is discussed in terms of the robust matching algorithms that must be devised. Stereo vision, camera control and calibration, and the hardware and systems architecture are discussed.

  13. World Foods. Can the World Feed Us?

    ERIC Educational Resources Information Center

    Hindman, Wanda; And Others

    This teacher's guide contains resources to facilitate the study of the world food situation in home economics classes. It provides terms, historical elements of famine, and the effects of hunger and dietary deficiency on humans. Brief overviews of the basic factors influencing the world food situation and some of the proposed measures to solve the…

  14. Nature, computation and complexity

    NASA Astrophysics Data System (ADS)

    Binder, P.-M.; Ellis, G. F. R.

    2016-06-01

    The issue of whether the unfolding of events in the world can be considered a computation is explored in this paper. We come to different conclusions for inert and for living systems (‘no’ and ‘qualified yes’, respectively). We suggest that physical computation as we know it exists only as a tool of complex biological systems: us.

  15. Networking computers.

    PubMed

    McBride, D C

    1997-03-01

    This decade the role of the personal computer has shifted dramatically from a desktop device designed to increase individual productivity and efficiency to an instrument of communication linking people and machines in different places with one another. A computer in one city can communicate with another that may be thousands of miles away. Networking is how this is accomplished. Just like the voice network used by the telephone, computer networks transmit data and other information via modems over these same telephone lines. A network can be created over both short and long distances. Networks can be established within a hospital or medical building or over many hospitals or buildings covering many geographic areas. Those confined to one location are called LANs, local area networks. Those that link computers in one building to those at other locations are known as WANs, or wide area networks. The ultimate wide area network is the one we've all been hearing so much about these days--the Internet, and its World Wide Web. Setting up a network is a process that requires careful planning and commitment. To avoid potential pitfalls and to make certain the network you establish meets your needs today and several years down the road, several steps need to be followed. This article reviews the initial steps involved in getting ready to network.

  16. Science in a Flat World (George B. Pegram Lecture Series)

    SciTech Connect

    Lane, Neal

    2006-09-12

    Lane discusses the changes that have taken place in the world since World War II that have made it "flatter," referring to Thomas L. Friedman's book, The World is Flat. Friedman's main premise is that inexpensive telecommunications is bringing about unhampered international competition, the demise of economic stability, and a trend toward outsourcing services, such as computer programming, engineering and science research.

  17. History of respiratory mechanics prior to World War II.

    PubMed

    West, John B

    2012-01-01

    The history of respiratory mechanics is reviewed over a period of some 2,500 years from the ancient Greeks to World War II. A cardinal early figure was Galen (130-199 AD) who made remarkably perceptive statements on the diaphragm and the anatomy of the phrenic nerves. The polymath Leonardo da Vinci (1452-1519) contributed observations on pulmonary mechanics including the pleural space and bronchial airflow that still make good reading. Vesalius (1514-1564) produced magnificent illustrations of the lung, ribcage, and diaphragm. In the 17th century, the Oxford School including Boyle, Hooke, Lower, and Mayow were responsible for many contributions on mechanical functions including the intercostal muscles and the pleura. Hales (1677-1761) calculated the size and surface area of the alveoli, the time spent by the blood in the pulmonary capillaries, and intrathoracic pressures. Poiseuille (1799-1869) carried out classical studies of fluid mechanics including one of the first demonstrations of flow limitation in collapsible vessels. The culmination of the pre-World War II period was the outstanding contributions of Rohrer (1888-1926) and his two Swiss countrymen, Wirz (1896-1978) and von Neergaard (1887-1947). Rohrer developed the first comprehensive, quantitative treatment of respiratory mechanics in the space of 10 years including an analysis of flow in airways, and the pressure-volume behavior of the respiratory system. von Neergaard performed landmark studies on the effects of surface tension on pressure-volume behavior. Progress over the 2,500 years was slow and erratic at times, but by 1940 the stage was set for the spectacular developments of the next 70 years.

  18. World Hunger: Teaching about World Hunger.

    ERIC Educational Resources Information Center

    Simpson, Jane

    1982-01-01

    Discusses the teaching of world hunger in the classroom. Controversial questions and map skills for students are discussed as well as activities for home economics and science classes. A list of resource materials is included. (AM)

  19. World Hunger: Teaching about World Hunger.

    ERIC Educational Resources Information Center

    Simpson, Jane

    1982-01-01

    Discusses the teaching of world hunger in the classroom. Controversial questions and map skills for students are discussed as well as activities for home economics and science classes. A list of resource materials is included. (AM)

  20. Maps of the World

    USGS Publications Warehouse

    ,

    1994-01-01

    Because a map conveys information visually, it is often the best way for presenting facts about the size, shape, and appearance of our world and about the changes that people have imposed on the world. Some world maps show the mountains, rivers, oceans, and plains that make up the face of the Earth. Some show only the boundaries that divide our world into nations. Others show the Earth's resources, population centers, or earthquake activity. Some combine many kinds of information.

  1. Virtual Worlds? "Outlook Good"

    ERIC Educational Resources Information Center

    Kelton, AJ

    2008-01-01

    Many people believed that virtual worlds would end up like the eight-track audiotape: a memory of something no longer used (or useful). Yet today there are hundreds of higher education institutions represented in three-dimensional (3D) virtual worlds such as Active Worlds and Second Life. The movement toward the virtual realm as a viable teaching…

  2. World Council-OMEP.

    ERIC Educational Resources Information Center

    Weiser, Margaret

    1990-01-01

    Details the 1990 meeting of the World Council of the World Organization for Early Childhood Education (OMEP) in Lagos, Nigeria. OMEP's Statement to the World Summit for Children is provided. The conditions of Nigerian children and female children in India are considered. (BG)

  3. Brief: Touch the world through Internet

    SciTech Connect

    Woolley, T.C. )

    1994-06-01

    Internet is the world's largest computer network. Access to Internet allows users to communicate with colleagues around the world, to access vast software archives, to visit university and public libraries, to search on-line databases, to participate in lively discussions on thousands of topics, to receive electronic journals, and much more. This paper describes Internet and discusses its current and future uses, ways to obtain access, and some of the resources available.

  4. State of the World 1984

    NASA Astrophysics Data System (ADS)

    Singer, S. Fred

    Long before Ronald Reagan asked voters whether they were better off today than they were 4 years ago, many thoughtful people were asking whether the world as a whole was becoming a better place to live. The Malthusian point of view, restated by the Club of Rome's Limits to Growth, made an enormous impact on the world when it appeared in 1972. Its simplistic message, disguised in computer models, was that exponential growth cannot be maintained forever. Specifically, it predicted imminent exhaustion of food and natural resources and death from evergrowing pollution. Its successor volume, Global 2000, published with the encouragement of the Carter White House in 1980, was more restrained but also predicted general doom. It was responded to by The Resourceful Earth (sponsored by the Heritage Foundation), which views the future as rosy and contradicts Global 2000 on almost every point.

  5. Computer Architecture's Changing Role in Rebooting Computing

    DOE PAGES

    DeBenedictis, Erik P.

    2017-04-26

    In this paper, Windows 95 started the Wintel era, in which Microsoft Windows running on Intel x86 microprocessors dominated the computer industry and changed the world. Retaining the x86 instruction set across many generations let users buy new and more capable microprocessors without having to buy software to work with new architectures.

  6. Common world model for unmanned systems

    NASA Astrophysics Data System (ADS)

    Dean, Robert Michael S.

    2013-05-01

    The Robotic Collaborative Technology Alliance (RCTA) seeks to provide adaptive robot capabilities which move beyond traditional metric algorithms to include cognitive capabilities. Key to this effort is the Common World Model, which moves beyond the state-of-the-art by representing the world using metric, semantic, and symbolic information. It joins these layers of information to define objects in the world. These objects may be reasoned upon jointly using traditional geometric, symbolic cognitive algorithms and new computational nodes formed by the combination of these disciplines. The Common World Model must understand how these objects relate to each other. Our world model includes the concept of Self-Information about the robot. By encoding current capability, component status, task execution state, and histories we track information which enables the robot to reason and adapt its performance using Meta-Cognition and Machine Learning principles. The world model includes models of how aspects of the environment behave, which enable prediction of future world states. To manage complexity, we adopted a phased implementation approach to the world model. We discuss the design of "Phase 1" of this world model, and interfaces by tracing perception data through the system from the source to the meta-cognitive layers provided by ACT-R and SS-RICS. We close with lessons learned from implementation and how the design relates to Open Architecture.

  7. New World View

    NASA Astrophysics Data System (ADS)

    Bainbridge, William Sims

    This chapter reports the wide range of ideas in a pair of major scientific conference meetings held inside the most popular virtual world, World of Warcraft (WoW), May 9 and May 10, 2008, plus the challenges of organizing these online events. More than a hundred scholars and scientists contributed to each session, the first covering research on World of Warcraft, and the second examining how virtual worlds fit into the larger world of human experience. A third session, held on May 11, was the starting point for the concluding chapter of this volume. This chapter describes how WoW and other virtual worlds can be used as laboratories for studying human behavior, using both qualitative and quantitative methodologies, and the affordances of virtual worlds can be used to support scientific communication (Bainbridge 2007, in press).

  8. Computers in Education: A Brief History.

    ERIC Educational Resources Information Center

    Molnar, Andrew R.

    1997-01-01

    Provides an overview of computers in education: early computers and computer languages, computer-assisted instruction, micro worlds, microcomputers, intelligent tutors, intelligent tools, symbol systems, computer graphics, virtual reality, distance education via the Internet, distance mentoring, learning-on-demand, organizational learning via…

  9. Computers in Education: A Brief History.

    ERIC Educational Resources Information Center

    Molnar, Andrew R.

    1997-01-01

    Provides an overview of computers in education: early computers and computer languages, computer-assisted instruction, micro worlds, microcomputers, intelligent tutors, intelligent tools, symbol systems, computer graphics, virtual reality, distance education via the Internet, distance mentoring, learning-on-demand, organizational learning via…

  10. The Computers in Our Lives.

    ERIC Educational Resources Information Center

    Uthe, Elaine F.

    1982-01-01

    Describes the growing use of computers in our world and how their use will affect vocational education. Discusses recordkeeping and database functions, computer graphics, problem-solving simulations, satellite communications, home computers, and how they will affect office education, home economics education, marketing and distributive education,…

  11. The scientific research potential of virtual worlds.

    PubMed

    Bainbridge, William Sims

    2007-07-27

    Online virtual worlds, electronic environments where people can work and interact in a somewhat realistic manner, have great potential as sites for research in the social, behavioral, and economic sciences, as well as in human-centered computer science. This article uses Second Life and World of Warcraft as two very different examples of current virtual worlds that foreshadow future developments, introducing a number of research methodologies that scientists are now exploring, including formal experimentation, observational ethnography, and quantitative analysis of economic markets or social networks.

  12. Teaching World Religions without Teaching "World Religions"

    ERIC Educational Resources Information Center

    Locklin, Reid B.; Tiemeier, Tracy; Vento, Johann M.

    2012-01-01

    Tomoko Masuzawa and a number of other contemporary scholars have recently problematized the categories of "religion" and "world religions" and, in some cases, called for its abandonment altogether as a discipline of scholarly study. In this collaborative essay, we respond to this critique by highlighting three attempts to teach…

  13. Teaching World Religions without Teaching "World Religions"

    ERIC Educational Resources Information Center

    Locklin, Reid B.; Tiemeier, Tracy; Vento, Johann M.

    2012-01-01

    Tomoko Masuzawa and a number of other contemporary scholars have recently problematized the categories of "religion" and "world religions" and, in some cases, called for its abandonment altogether as a discipline of scholarly study. In this collaborative essay, we respond to this critique by highlighting three attempts to teach…

  14. The Third World Is a Different World.

    ERIC Educational Resources Information Center

    Oliver, Leonard P.

    The Third World Assembly of Adult Education held in Buenos Aires, Argentina, November 24-30, 1985, brought 450 adult educators from 90 countries together to discuss the theme adult education, development, and peace. The week-long conference mixed morning general sessions with 17 intensive work groups. The first work group searched for common…

  15. A social implications of computing course which teaches computer ethics

    SciTech Connect

    Pulliam, S.C.

    1994-12-31

    Computers are integral to today`s world, forming our society as well as responding to it, In recognition of this interaction, as well as in response to requirements by the Computer Science Accrediting Board (CSAB), many schools are incorporating computer ethics and values and addressing the social implications of computing within their curriculum. The approach discussed here is through a separate course, rather than relying on the integration of specific topics throughout the curriculum.

  16. Chapter 6: after Galen Late Antiquity and the Islamic world.

    PubMed

    Russell, Gül A

    2010-01-01

    It is usually assumed that after Galen there was nothing new until the Renaissance. Contrary to this view, there were significant modifications of the inherited legacy in Late Antiquity, followed by fundamental changes within the Arabic/Islamic world. Their formative influence extends from the medieval period of transmission to the Renaissance and the 17th century. The increasing emphasis on the primacy of the brain initiated the beginnings of ventricular localization of function in Late Antiquity, which was subsequently developed into a theory and transmitted to the West via Arabic. Following the unprecedented translation movement in 9th-century Baghdad, the cumulative Greek and Hellenistic knowledge of the brain, nerves, and the senses from diverse sources were brought together in the systematic, logically unified Arabic medical compendia of encyclopedic proportions, which embody divergence from accepted views and new diagnostic observations. Their Latin versions became standard texts in medical schools. The oldest extant schematic diagrams relevant to neurology (the eye, the ventricles, the visual system, and the nerves) date from this period, and served as models for the medieval Latin West. The development of coherent descriptions of the motor and sensory systems, and related clinical disorders, by analogy with the mechanisms of hydraulic automata, foreshadows some of the explanatory methods associated with the 17th century. Furthermore, an entirely new approach resulted in a paradigm shift in theory and methodology through the experimental studies on the physics of light and vision of Ibn al-Haytham (d. 1040), who showed that what is sensed is not the object itself, but a punctate optical "image" due to light reflected from its surface to the eye. This revolutionary approach to vision destroyed the viability of the Greek tradition of holistic forms and tactile sensory impressions. Ibn al-Haytham's theory of point-to-point correspondence formed the basis of

  17. Computers: Yesterday, Today & Tomorrow.

    DTIC Science & Technology

    1986-04-07

    primary means of calculating until the 17 th century. PASCAL’S CALCULATOR 1642 The next significant advance in man’s ability to calculate was Blaise ...business terms. Because of this fact, the logic of COBOL is more easily understood by non-programmers. PAS CAL Pascal was developed as a language to be...conducive to good programming style. As a result, Pascal encourages the writing of disciplined, organized programs that foster increased programmer

  18. Operation of the World Master in the World Modeling System

    DTIC Science & Technology

    1987-10-01

    This research note describes the operation of the World Master process of the World Modeling System. It is intended to be an aid to maintainers of ... the World Master, and implementors of additional simulated physical properties of the world . The World Master is the core of the World Modeling System

  19. From computational quantum chemistry to computational biology: experiments and computations are (full) partners.

    PubMed

    Ma, Buyong; Nussinov, Ruth

    2004-12-01

    Computations are being integrated into biological research at an increasingly fast pace. This has not only changed the way in which biological information is managed; it has also changed the way in which experiments are planned in order to obtain information from nature. Can experiments and computations be full partners? Computational chemistry has expanded over the years, proceeding from computations of a hydrogen molecule toward the challenging goal of systems biology, which attempts to handle the entire living cell. Applying theories from ab initio quantum mechanics to simplified models, the virtual worlds explored by computations provide replicas of real-world phenomena. At the same time, the virtual worlds can affect our perception of the real world. Computational biology targets a world of complex organization, for which a unified theory is unlikely to exist. A computational biology model, even if it has a clear physical or chemical basis, may not reduce to physics and chemistry. At the molecular level, computational biology and experimental biology have already been partners, mutually benefiting from each other. For the perception to become reality, computation and experiment should be united as full partners in biological research.

  20. PERSPECTIVE: From computational quantum chemistry to computational biology: experiments and computations are (full) partners

    NASA Astrophysics Data System (ADS)

    Ma, Buyong; Nussinov, Ruth

    2004-12-01

    Computations are being integrated into biological research at an increasingly fast pace. This has not only changed the way in which biological information is managed; it has also changed the way in which experiments are planned in order to obtain information from nature. Can experiments and computations be full partners? Computational chemistry has expanded over the years, proceeding from computations of a hydrogen molecule toward the challenging goal of systems biology, which attempts to handle the entire living cell. Applying theories from ab initio quantum mechanics to simplified models, the virtual worlds explored by computations provide replicas of real-world phenomena. At the same time, the virtual worlds can affect our perception of the real world. Computational biology targets a world of complex organization, for which a unified theory is unlikely to exist. A computational biology model, even if it has a clear physical or chemical basis, may not reduce to physics and chemistry. At the molecular level, computational biology and experimental biology have already been partners, mutually benefiting from each other. For the perception to become reality, computation and experiment should be united as full partners in biological research.

  1. THE MAN MADE WORLD, LABORATORY MANUAL.

    ERIC Educational Resources Information Center

    Commission on Engineering Education, Washington, DC.

    THIS LABORATORY MANUAL, THE COMPANION VOLUME TO THE STUDENT'S TEXT FOR THE "MAN MADE WORLD" HIGH SCHOOL COURSE, CONTAINS 31 EXPERIMENTS DEALING WITH THE THEORY, CIRCUITRY, AND OPERATION OF COMPUTERS, AND RELATED TECHNOLOGY. THE COURSE WAS WRITTEN BY SCIENTISTS, ENGINEERS, AND EDUCATORS, AND IS INTENDED AS A PART OF THE CULTURAL CURRICULUM FOR ALL…

  2. When Worlds Collide: An Augmented Reality Check

    ERIC Educational Resources Information Center

    Villano, Matt

    2008-01-01

    The technology is simple: Mobile technologies such as handheld computers and global positioning systems work in sync to create an alternate, hybrid world that mixes virtual characters with the actual physical environment. The result is a digital simulation that offers powerful game-playing opportunities and allows students to become more engaged…

  3. When Worlds Collide: An Augmented Reality Check

    ERIC Educational Resources Information Center

    Villano, Matt

    2008-01-01

    The technology is simple: Mobile technologies such as handheld computers and global positioning systems work in sync to create an alternate, hybrid world that mixes virtual characters with the actual physical environment. The result is a digital simulation that offers powerful game-playing opportunities and allows students to become more engaged…

  4. Conversational Agents in Virtual Worlds: Bridging Disciplines

    ERIC Educational Resources Information Center

    Veletsianos, George; Heller, Robert; Overmyer, Scott; Procter, Mike

    2010-01-01

    This paper examines the effective deployment of conversational agents in virtual worlds from the perspective of researchers/practitioners in cognitive psychology, computing science, learning technologies and engineering. From a cognitive perspective, the major challenge lies in the coordination and management of the various channels of information…

  5. Number Concepts with "Number Worlds": Thickening Understandings

    ERIC Educational Resources Information Center

    Liljedahl, Peter; Sinclair, Nathalie; Zazkis, Rina

    2006-01-01

    This study focuses on the nature of preservice elementary school teachers' understandings of several concepts in elementary number theory that are evoked by a computer-based microworld called "Number Worlds". In particular, the focus is on the concepts of factor, multiple and prime number. The notion of "thickness" is examined with respect to…

  6. Conversational Agents in Virtual Worlds: Bridging Disciplines

    ERIC Educational Resources Information Center

    Veletsianos, George; Heller, Robert; Overmyer, Scott; Procter, Mike

    2010-01-01

    This paper examines the effective deployment of conversational agents in virtual worlds from the perspective of researchers/practitioners in cognitive psychology, computing science, learning technologies and engineering. From a cognitive perspective, the major challenge lies in the coordination and management of the various channels of information…

  7. Hello! Kids Network around the World.

    ERIC Educational Resources Information Center

    Lynes, Kristine

    1996-01-01

    Describes Kids Network, an educational network available from the National Geographic Society that allows students in grades four through six to become part of research teams that include students from around the world. Computer hardware requirements and a list of Kids Network research questions are listed in a sidebar. (JMV)

  8. Corporate Learning in a Virtual World

    ERIC Educational Resources Information Center

    Cole, Anne; Berge, Zane L.

    2009-01-01

    Corporate training professionals led the explosion of e-learning solutions in the 1990s. Yet in 2008, as new generations of technology-savvy, computer games-oriented employees are entering the workforce, corporate training departments are far behind universities in exploring the use of virtual worlds like Second Life or Protosphere as platforms…

  9. Cellphones and Real-World Communication

    ERIC Educational Resources Information Center

    Bugeja, Michael

    2004-01-01

    In this article, the author shares his views on cellphones and real-world communication. He claims that the cellphone has changed society more than the home computer, which it has assimilated. Cellphones sound during worship, wakes, births, graduations, hearings, trials, and accreditation meetings--interrupting life-changing spiritual or secular…

  10. Cellphones and Real-World Communication

    ERIC Educational Resources Information Center

    Bugeja, Michael

    2004-01-01

    In this article, the author shares his views on cellphones and real-world communication. He claims that the cellphone has changed society more than the home computer, which it has assimilated. Cellphones sound during worship, wakes, births, graduations, hearings, trials, and accreditation meetings--interrupting life-changing spiritual or secular…

  11. Hello! Kids Network around the World.

    ERIC Educational Resources Information Center

    Lynes, Kristine

    1996-01-01

    Describes Kids Network, an educational network available from the National Geographic Society that allows students in grades four through six to become part of research teams that include students from around the world. Computer hardware requirements and a list of Kids Network research questions are listed in a sidebar. (JMV)

  12. Helping high schoolers move the (virtual) world.

    PubMed

    Domik, Gitta; Arens, Stephan; Stilow, Peter; Friedrich, Hauke

    2013-01-01

    In a workshop, high school students built a virtual world for a car-racing game. The prerequisites were math-rather than programming-skills; instructional scaffolding (OpenGL templates and tutors) aided students through their programming tasks. This workshop was an alternative to other measures (for example, Microsoft's recent campaign) to get high school students interested in computer science.

  13. Ballooning dispersal using silk: world fauna, phylogenies, genetics and models.

    PubMed

    Bell, J R; Bohan, D A; Shaw, E M; Weyman, G S

    2005-04-01

    Aerial dispersal using silk ('ballooning') has evolved in spiders (Araneae), spider mites (Acari) and in the larvae of moths (Lepidoptera). Since the 17th century, over 500 observations of ballooning behaviours have been published, yet there is an absence of any evolutionary synthesis of these data. In this paper the literature is reviewed, extensively documenting the known world fauna that balloon and the principal behaviours involved. This knowledge is then incorporated into the current evolutionary phylogenies to examine how ballooning might have arisen. Whilst it is possible that ballooning co-evolved with silk and emerged as early as the Devonian (410-355 mya), it is arguably more likely that ballooning evolved in parallel with deciduous trees, herbaceous annuals and grasses in the Cretaceous (135-65 mya). During this period, temporal (e.g. bud burst, chlorophyll thresholds) and spatial (e.g. herbivory, trampling) heterogeneities in habitat structuring predominated and intensified into the Cenozoic (65 mya to the present). It is hypothesized that from the ancestral launch mechanism known as 'suspended ballooning', widely used by individuals in plant canopies, 'tip-toe' and 'rearing' take-off behaviours were strongly selected for as habitats changed. It is contended that ballooning behaviour in all three orders can be described as a mixed Evolutionary Stable Strategy. This comprises individual bet-hedging due to habitat unpredictability, giving an underlying randomness to individual ballooning, with adjustments to the individual ballooning probability being conferred by more predictable habitat changes or colonization strategies. Finally, current methods used to study ballooning, including modelling and genetic research, are illustrated and an indication of future prospects given.

  14. World War II Homefront.

    ERIC Educational Resources Information Center

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  15. World-Class Leaders

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2012-01-01

    Future leaders' creativity and problem-solving skills have been honed in leadership courses, but that doesn't mean they are ready to use those skills to further a company's place in the world. With emerging markets in Asia, South America, and other areas of the world, a workforce needs to have an understanding of and interest in cultures beyond…

  16. Land and World Order.

    ERIC Educational Resources Information Center

    Mische, Patricia, Ed.; And Others

    1982-01-01

    The papers in this publication discuss the land and how what happens to the land affects us. The publication is one in a series of monographs that examine the linkages between local and global concerns and explore alternative world futures. Examples of topics discussed in the papers follow. The paper "Land and World Order" examines…

  17. World Music Ensemble: Kulintang

    ERIC Educational Resources Information Center

    Beegle, Amy C.

    2012-01-01

    As instrumental world music ensembles such as steel pan, mariachi, gamelan and West African drums are becoming more the norm than the exception in North American school music programs, there are other world music ensembles just starting to gain popularity in particular parts of the United States. The kulintang ensemble, a drum and gong ensemble…

  18. Soap. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  19. Charcoal. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  20. Xchanging the World.

    ERIC Educational Resources Information Center

    Blythe, Chris; Richards, Dave

    This activity pack goes beyond exposing the low prices paid to commodity producers and explores broader structures that govern world trade and produce poverty and inequality. The pack encourages young people to look beyond the labels and consider the responsibilities consumers have toward the people who feed and clothe the world, or make the…

  1. On Observing World English.

    ERIC Educational Resources Information Center

    Urdang, Lawrence

    1990-01-01

    Reviews the current state of World English. Subjects addressed include standard accents and dialects, prejudicial attitudes toward nonstandard "local" usages, the use of English as the language of diplomacy, American influences on the language, and the fracturing of English in non-English-speaking countries around the world. (17 references) (JL)

  2. Distillation. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  3. Xchanging the World.

    ERIC Educational Resources Information Center

    Blythe, Chris; Richards, Dave

    This activity pack goes beyond exposing the low prices paid to commodity producers and explores broader structures that govern world trade and produce poverty and inequality. The pack encourages young people to look beyond the labels and consider the responsibilities consumers have toward the people who feed and clothe the world, or make the…

  4. Educating for World Cooperation.

    ERIC Educational Resources Information Center

    Berman, Louise M.; Miel, Alice

    This booklet presents a variety of perspectives on educating for world cooperation. Section 1 discusses major world problems and calls for the reorientation of education as a potential solution. Section 2 deals with the design of such a reorientation and offers three approaches to teaching and curriculum development--knowing, being, and doing. In…

  5. Towards Developmental World Englishes

    ERIC Educational Resources Information Center

    Bolton, Kingsley; Graddol, David; Meierkord, Christiane

    2011-01-01

    Over the last three decades scholars promoting the world Englishes paradigm (WE) have worked towards establishing a more positive attitude towards international varieties of English. However, despite the best intentions of Western linguists working in this field, there is an obvious imbalance between the developed and developing world in many…

  6. Fermentation. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  7. Fermentation. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  8. Educating for World Cooperation.

    ERIC Educational Resources Information Center

    Berman, Louise M.; Miel, Alice

    This booklet presents a variety of perspectives on educating for world cooperation. Section 1 discusses major world problems and calls for the reorientation of education as a potential solution. Section 2 deals with the design of such a reorientation and offers three approaches to teaching and curriculum development--knowing, being, and doing. In…

  9. World Music Resources

    ERIC Educational Resources Information Center

    Beegle, Amy C.

    2012-01-01

    Access to world music resources such as videos and sound recordings have increased with the advent of YouTube and the efforts of music educators working closely with ethnomusicologists to provide more detailed visual and audio information about various musical practices. This column discusses some world music resources available for music…

  10. The World without Us

    ERIC Educational Resources Information Center

    Duchesne, Ricardo

    2009-01-01

    In this article, the author reviews several books on world history from the 1920s to the 1940s. These include books authored by a diverse group: H.G. Wells, "Outline of History" (Macmillan, 1920); James Henry Breasted, "Ancient Times, A History of the Early World" (published in 1916 by Ginn and Company and largely rewritten in 1935); M.…

  11. Education and World Order

    ERIC Educational Resources Information Center

    Jones, Phillip W.

    2007-01-01

    The impact on educational analysis of mainstream international relations (IR) theories is yet to realize its full potential. The problem of education in relation to the construction of world order is considered in relation to core developments in IR theory since the Second World War. In particular, the global architecture of education is seen as a…

  12. Bioregions and World Order.

    ERIC Educational Resources Information Center

    Breakthrough, 1985

    1985-01-01

    What bioregions can do to contribute to world order and security is discussed in this newsletter. A bioregion is defined as an identifiable geographical area of interacting life-systems that is relatively self-sustaining in the ever-renewing processes of nature. Articles included are: "Bioregionalism and World Order" (Gerald Mische);…

  13. Distillation. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  14. Salt. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…

  15. World-Class Leaders

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2012-01-01

    Future leaders' creativity and problem-solving skills have been honed in leadership courses, but that doesn't mean they are ready to use those skills to further a company's place in the world. With emerging markets in Asia, South America, and other areas of the world, a workforce needs to have an understanding of and interest in cultures beyond…

  16. World War II Homefront.

    ERIC Educational Resources Information Center

    Garcia, Rachel

    2002-01-01

    Presents an annotated bibliography that provides Web sites focusing on the U.S. homefront during World War II. Covers various topics such as the homefront, Japanese Americans, women during World War II, posters, and African Americans. Includes lesson plan sources and a list of additional resources. (CMK)

  17. World Music Ensemble: Kulintang

    ERIC Educational Resources Information Center

    Beegle, Amy C.

    2012-01-01

    As instrumental world music ensembles such as steel pan, mariachi, gamelan and West African drums are becoming more the norm than the exception in North American school music programs, there are other world music ensembles just starting to gain popularity in particular parts of the United States. The kulintang ensemble, a drum and gong ensemble…

  18. Land and World Order.

    ERIC Educational Resources Information Center

    Mische, Patricia, Ed.; And Others

    1982-01-01

    The papers in this publication discuss the land and how what happens to the land affects us. The publication is one in a series of monographs that examine the linkages between local and global concerns and explore alternative world futures. Examples of topics discussed in the papers follow. The paper "Land and World Order" examines…

  19. Virtual Worlds for Educators

    ERIC Educational Resources Information Center

    Dembo, Steve

    2008-01-01

    This article describes an online experience that has not only created a fantasy world for the general public but has enabled some tech-savvy educators to create virtual educational opportunities. Second Life, or SL, is a 3-D Internet-based virtual world created by Linden Lab and populated by nearly 1,000,000 active users worldwide since 2003.…

  20. Soap. Third World Science.

    ERIC Educational Resources Information Center

    Jones, Natalie; Hughes, Wyn

    This unit, developed by the Third World Science Project, is designed to add a multicultural element to existing science syllabi (for students aged 11-16) in the United Kingdom. The project seeks to develop an appreciation of the: boundless fascination of the natural world; knowledge, skills, and expertise possessed by men/women everywhere;…