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Sample records for 18 31 33

  1. Genetic variability and phylogeny of high risk HPV type 16, 18, 31, 33 and 45 L1 gene in Greek women.

    PubMed

    Ntova, Chara Kleio; Kottaridi, Christine; Chranioti, Aikaterini; Spathis, Aris; Kassanos, Dimitrios; Paraskevaidis, Evangelos; Karakitsos, Petros

    2012-01-01

    The present study explores nucleotide variability, phylogeny and association with cervical neoplasia in high risk HPV types 16, 18, 31, 33 and 45 collected from Greek women. Of the 1894 women undergoing routine cervical cytology examination, 160 samples test positive for single infections of HPV type 16 (n = 104), HPV 31 (n = 40), HPV 33 (n = 7), HPV 18 (n = 5), and HPV 45 (n = 4) were typed by microarrays method, amplified by PCR then sequenced and phylogenetically analyzed. For HPV 16, 9 variants with nucleotide variations were included into the study. For HPV 31, 33, 18 and 45, nucleotide variations were identified in 6, 4, 2 and 3 variants, respectively. The Bayesian inference and Maximum Parsimony methods were used in order to construct the phylogenetic trees. When types were analyzed independently HPV 16 (European and non-European) and HPV 18 (African and non-African) formed distinct clades. The genomic characterization of HPV variants will be important for illuminating the geographical relatedness and biological differences and for the determination of their risk.

  2. Genetic Variability and Phylogeny of High Risk HPV Type 16, 18, 31, 33 and 45 L1 Gene in Greek Women

    PubMed Central

    Ntova, Chara Kleio; Kottaridi, Christine; Chranioti, Aikaterini; Spathis, Aris; Kassanos, Dimitrios; Paraskevaidis, Evangelos; Karakitsos, Petros

    2012-01-01

    The present study explores nucleotide variability, phylogeny and association with cervical neoplasia in high risk HPV types 16, 18, 31, 33 and 45 collected from Greek women. Of the 1894 women undergoing routine cervical cytology examination, 160 samples test positive for single infections of HPV type 16 (n = 104), HPV 31 (n = 40), HPV 33 (n = 7), HPV 18 (n = 5), and HPV 45 (n = 4) were typed by microarrays method, amplified by PCR then sequenced and phylogenetically analyzed. For HPV 16, 9 variants with nucleotide variations were included into the study. For HPV 31, 33, 18 and 45, nucleotide variations were identified in 6, 4, 2 and 3 variants, respectively. The Bayesian inference and Maximum Parsimony methods were used in order to construct the phylogenetic trees. When types were analyzed independently HPV 16 (European and non-European) and HPV 18 (African and non-African) formed distinct clades. The genomic characterization of HPV variants will be important for illuminating the geographical relatedness and biological differences and for the determination of their risk. PMID:22312235

  3. 30 CFR 33.31 - Test space.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Test space. 33.31 Section 33.31 Mineral... § 33.31 Test space. (a) Drilling tests shall be conducted in a test space formed by two curtains suspended across a mine opening in such a manner that the volume of the test space shall be approximately...

  4. 30 CFR 33.31 - Test space.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Test space. 33.31 Section 33.31 Mineral... § 33.31 Test space. (a) Drilling tests shall be conducted in a test space formed by two curtains suspended across a mine opening in such a manner that the volume of the test space shall be approximately...

  5. 30 CFR 33.31 - Test space.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Test space. 33.31 Section 33.31 Mineral... MINING PRODUCTS DUST COLLECTORS FOR USE IN CONNECTION WITH ROCK DRILLING IN COAL MINES Test Requirements § 33.31 Test space. (a) Drilling tests shall be conducted in a test space formed by two...

  6. 14 CFR 31.33 - Materials.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... design data. (b) Material strength properties must be based on enough tests of material conforming to... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Materials. 31.33 Section 31.33 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.33 Materials. (a) The suitability and durability...

  7. 14 CFR 31.33 - Materials.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... design data. (b) Material strength properties must be based on enough tests of material conforming to... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Materials. 31.33 Section 31.33 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.33 Materials. (a) The suitability and durability...

  8. 14 CFR 31.33 - Materials.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... design data. (b) Material strength properties must be based on enough tests of material conforming to... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Materials. 31.33 Section 31.33 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.33 Materials. (a) The suitability and durability...

  9. 14 CFR 31.33 - Materials.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... design data. (b) Material strength properties must be based on enough tests of material conforming to... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Materials. 31.33 Section 31.33 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.33 Materials. (a) The suitability and durability...

  10. 14 CFR 31.33 - Materials.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... design data. (b) Material strength properties must be based on enough tests of material conforming to... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Materials. 31.33 Section 31.33 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.33 Materials. (a) The suitability and durability...

  11. 30 CFR 33.31 - Test space.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Test space. 33.31 Section 33.31 Mineral... § 33.31 Test space. (a) Drilling tests shall be conducted in a test space formed by two curtains suspended across a mine opening in such a manner that the volume of the test space shall be approximately...

  12. 30 CFR 33.31 - Test space.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Test space. 33.31 Section 33.31 Mineral... § 33.31 Test space. (a) Drilling tests shall be conducted in a test space formed by two curtains suspended across a mine opening in such a manner that the volume of the test space shall be approximately...

  13. 32 CFR 33.31 - Real property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Real property. 33.31 Section 33.31 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Changes, Property,...

  14. 33 CFR 62.31 - Special marks.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Special marks. 62.31 Section 62.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.31 Special marks....

  15. 33 CFR 62.31 - Special marks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Special marks. 62.31 Section 62.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.31 Special marks....

  16. 33 CFR 62.31 - Special marks.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Special marks. 62.31 Section 62.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.31 Special marks....

  17. 33 CFR 62.31 - Special marks.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Special marks. 62.31 Section 62.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.31 Special marks....

  18. 33 CFR 62.31 - Special marks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Special marks. 62.31 Section 62.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION UNITED STATES AIDS TO NAVIGATION SYSTEM The U.S. Aids to Navigation System § 62.31 Special marks....

  19. 49 CFR 18.31 - Real property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Real property. 18.31 Section 18.31 Transportation... AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Changes, Property, and Subawards § 18.31 Real property. (a) Title. Subject to the obligations and conditions set forth in this section, title...

  20. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  1. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  2. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  3. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  4. 18 CFR 35.33 - Specific provisions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Specific provisions. 35.33 Section 35.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... Governing Nuclear Plant Decommissioning Trust Funds § 35.33 Specific provisions. (a) In addition to...

  5. Comparison of the detection of HPV-16, 18, 31, 33, and 45 by type-specific DNA- and E6/E7 mRNA-based assays of HPV DNA positive women with abnormal Pap smears.

    PubMed

    Salimović-Bešić, Irma; Tomić-Čiča, Anja; Smailji, Admir; Hukić, Mirsada

    2013-12-01

    This study compares the type-specific human papillomavirus (HPV) DNA test with E6/E7 mRNA detection assay because of their importance in cervical cancer screening programs. A total of 105 women with positive high-risk Hybrid Capture 2 or Abbott RealTime High Risk HPV screening test and an abnormal cervical Pap smear were enrolled in the study. HPV typing was performed by multiplex real-time PCR (HPV High Risk Typing Real-TM test). HPV-16, 18, 31, 33, and 45 E6/E7 mRNAs were determined by type-specific real-time NASBA assay (NucliSENS EasyQ HPV v1.1). Infections caused by HPV-16, 18, 31, 33, and 45 types increased with severity of cervical cytology (p=0.008). Global positivity of five HPV E6/E7 mRNAs was lower than DNA positivity within women with atypical squamous cells of undetermined significance (p=0.016; p=0.008). High agreement of the tests was found in the groups of women with low-grade (p=1.000; p=0.063) and high-grade squamous intraepithelial lesion (p=0.250; p=0.125). Type-specific agreement of both diagnostic approaches was high regardless of cytology. Based on the found differences between HPV-16, 18, 31, 33, and 45 E6/E7 mRNA and DNA positivity, further study is needed to test the role of mRNA testing in the triage of women with atypical squamous cells of undetermined significance in Pap smear.

  6. 33 CFR 273.18 - Clearinghouse coordination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Clearinghouse coordination. 273.18 Section 273.18 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL § 273.18 Clearinghouse coordination. Procedures prescribed...

  7. 18 CFR 157.31 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 157.31 Section 157.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT... Seasons for Alaska Natural Gas Transportation Projects § 157.31 Definitions. (a) “Alaska natural...

  8. 18 CFR 401.31 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Scope. 401.31 Section 401.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact § 401.31 Scope....

  9. 27 CFR 18.31 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false General requirements. 18.31 Section 18.31 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification...

  10. 27 CFR 18.31 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false General requirements. 18.31 Section 18.31 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification...

  11. 17 CFR 31.18 - Margin calls.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Margin calls. 31.18 Section 31....18 Margin calls. (a) No leverage transaction merchant shall liquidate a leverage contract because of... after contact is effected in which to respond to a margin call. Twenty-four hours, excluding...

  12. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Administrative agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Project Review Under Section 3.8 of the Compact §...

  13. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Administrative agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... federal or state law as follows: (a) To facilitate the submission and review of applications and...

  14. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Administrative agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... federal or state law as follows: (a) To facilitate the submission and review of applications and...

  15. 18 CFR 401.33 - Administrative agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Administrative agreements. 401.33 Section 401.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... federal or state law as follows: (a) To facilitate the submission and review of applications and...

  16. 18 CFR 1308.33 - Hearings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Hearings. 1308.33 Section 1308.33 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY CONTRACT DISPUTES... granted, may move for a dismissal on the ground that upon the facts and the law the Contractor has...

  17. 18 CFR 1308.33 - Hearings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Hearings. 1308.33 Section 1308.33 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY CONTRACT DISPUTES... granted, may move for a dismissal on the ground that upon the facts and the law the Contractor has...

  18. 18 CFR 1308.33 - Hearings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Hearings. 1308.33 Section 1308.33 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY CONTRACT DISPUTES... granted, may move for a dismissal on the ground that upon the facts and the law the Contractor has...

  19. 18 CFR 12.33 - Exemption.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Exemption. 12.33 Section 12.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  20. 18 CFR 12.33 - Exemption.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Exemption. 12.33 Section 12.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  1. 18 CFR 12.33 - Exemption.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Exemption. 12.33 Section 12.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  2. 18 CFR 12.33 - Exemption.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Exemption. 12.33 Section 12.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  3. 18 CFR 12.33 - Exemption.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Exemption. 12.33 Section 12.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  4. 18 CFR 33.10 - Additional information.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additional information. 33.10 Section 33.10 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS UNDER FEDERAL POWER ACT SECTION...

  5. 33 CFR 401.18 - Steering lights.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Steering lights. 401.18 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.18 Steering lights. Every vessel shall be equipped with: (a) A steering light located on the centerline at or near the stem of...

  6. 33 CFR 401.18 - Steering lights.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Steering lights. 401.18 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.18 Steering lights. Every vessel shall be equipped with: (a) A steering light located on the centerline at or near the stem of...

  7. 33 CFR 401.18 - Steering lights.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Steering lights. 401.18 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.18 Steering lights. Every vessel shall be equipped with: (a) A steering light located on the centerline at or near the stem of...

  8. 33 CFR 401.18 - Steering lights.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Steering lights. 401.18 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.18 Steering lights. Every vessel shall be equipped with: (a) A steering light located on the centerline at or near the stem of...

  9. 33 CFR 401.18 - Steering lights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Steering lights. 401.18 Section... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Condition of Vessels § 401.18 Steering lights. Every vessel shall be equipped with: (a) A steering light located on the centerline at or near the stem of...

  10. 31 CFR 92.18 - Judicial review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Judicial review. 92.18 Section 92.18 Money and Finance: Treasury Regulations Relating to Money and Finance UNITED STATES MINT OPERATIONS AND... States Mint § 92.18 Judicial review. A Final Notice of Assessment issued under the procedures in...

  11. 18 CFR 5.31 - Transition provision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Transition provision. 5.31 Section 5.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  12. 18 CFR 5.31 - Transition provision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Transition provision. 5.31 Section 5.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  13. 18 CFR 5.31 - Transition provision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Transition provision. 5.31 Section 5.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  14. 18 CFR 5.31 - Transition provision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Transition provision. 5.31 Section 5.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  15. 18 CFR 5.31 - Transition provision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Transition provision. 5.31 Section 5.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS §...

  16. 18 CFR 12.31 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... judgment of the Commission or its authorized representative, might endanger human life or cause significant... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Definitions. 12.31... Inspection by Independent Consultant § 12.31 Definitions. For purposes of this subpart: (a)...

  17. 18 CFR 12.31 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 12.31 Section 12.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  18. 18 CFR 12.31 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Definitions. 12.31 Section 12.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  19. 18 CFR 12.31 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Definitions. 12.31 Section 12.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  20. 18 CFR 12.31 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Definitions. 12.31 Section 12.31 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT...

  1. 30 CFR 18.33 - Finish of surface joints.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Finish of surface joints. 18.33 Section 18.33 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Requirements § 18.33 Finish of surface joints. Flat surfaces between bolt holes that form any part of a...

  2. 30 CFR 18.33 - Finish of surface joints.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Finish of surface joints. 18.33 Section 18.33 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Requirements § 18.33 Finish of surface joints. Flat surfaces between bolt holes that form any part of a...

  3. 30 CFR 18.33 - Finish of surface joints.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Finish of surface joints. 18.33 Section 18.33 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Requirements § 18.33 Finish of surface joints. Flat surfaces between bolt holes that form any part of a...

  4. 30 CFR 18.33 - Finish of surface joints.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Finish of surface joints. 18.33 Section 18.33 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Requirements § 18.33 Finish of surface joints. Flat surfaces between bolt holes that form any part of a...

  5. 30 CFR 18.33 - Finish of surface joints.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Finish of surface joints. 18.33 Section 18.33 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... Requirements § 18.33 Finish of surface joints. Flat surfaces between bolt holes that form any part of a...

  6. 49 CFR 393.31-393.33 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false 393.31-393.33 Section 393.31-393.33 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective...

  7. 49 CFR 553.31-553.33 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false 553.31-553.33 Section 553.31-553.33 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RULEMAKING PROCEDURES Procedures for Adoption of Rules §§...

  8. 33 CFR 157.31 - Discharges: Chemical additives.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Discharges: Chemical additives. 157.31 Section 157.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... OIL IN BULK Vessel Operation § 157.31 Discharges: Chemical additives. No person may use a...

  9. 33 CFR 157.31 - Discharges: Chemical additives.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Discharges: Chemical additives. 157.31 Section 157.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... OIL IN BULK Vessel Operation § 157.31 Discharges: Chemical additives. No person may use a...

  10. 33 CFR 157.31 - Discharges: Chemical additives.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Discharges: Chemical additives. 157.31 Section 157.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... OIL IN BULK Vessel Operation § 157.31 Discharges: Chemical additives. No person may use a...

  11. 33 CFR 157.31 - Discharges: Chemical additives.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Discharges: Chemical additives. 157.31 Section 157.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... OIL IN BULK Vessel Operation § 157.31 Discharges: Chemical additives. No person may use a...

  12. 33 CFR 157.31 - Discharges: Chemical additives.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Discharges: Chemical additives. 157.31 Section 157.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... OIL IN BULK Vessel Operation § 157.31 Discharges: Chemical additives. No person may use a...

  13. THE NEUTRAL HYDROGEN BRIDGE BETWEEN M31 AND M33

    SciTech Connect

    Lockman, Felix J.; Free, Nicole L.; Shields, Joseph C.

    2012-08-15

    The Green Bank Telescope has been used to search for 21 cm H I emission over a large area between the galaxies M31 and M33 in an attempt to confirm at 9.'1 angular resolution the detection by Braun and Thilker of a very extensive neutral gas 'bridge' between the two systems at the level N{sub HI} Almost-Equal-To 10{sup 17} cm{sup -2}. We detect H I emission at several locations up to 120 kpc in projected distance from M31, at least half the distance to M33, with velocities similar to that of the galaxies, confirming the essence of the Braun and Thilker discovery. The H I does not appear to be associated with the extraplanar high-velocity clouds of either galaxy. In two places we measure N{sub HI} > 3 Multiplication-Sign 10{sup 18} cm{sup -2}, indicative of concentrations of H I with {approx}10{sup 5} M{sub Sun} on scales {approx}< 2 kpc, but over most of the field we have only 5{sigma} upper limits of N{sub HI} {<=} 1.4 Multiplication-Sign 10{sup 18} cm{sup -2}. In very deep measurements in two directions H I lines were detected at a few 10{sup 17} cm{sup -2}. The absence of emission at another location to a 5{sigma} limit N{sub HI} {<=} 1.5 Multiplication-Sign 10{sup 17} cm{sup -2} suggests that the H I bridge is either patchy or confined to within {approx}125 kpc of M31. The measurements also cover two of M31's dwarf galaxies, And II and And XV, but in neither case is there evidence for associated H I at the 5{sigma} level of 1.4 Multiplication-Sign 10{sup 4} M{sub Sun} for And II and 9.3 Multiplication-Sign 10{sup 3} M{sub Sun} for And XV.

  14. 18 CFR 430.33 - Duration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... REGULATIONS GROUND WATER PROTECTION AREA: PENNSYLVANIA § 430.33 Duration. The delineation and declaration of the Southeastern Pennsylvania Ground Water Protected Area made pursuant to this regulation, and...

  15. 18 CFR 430.33 - Duration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... REGULATIONS GROUND WATER PROTECTION AREA: PENNSYLVANIA § 430.33 Duration. The delineation and declaration of the Southeastern Pennsylvania Ground Water Protected Area made pursuant to this regulation, and...

  16. 18 CFR 420.33 - Payment of bills.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Payment of bills. 420.33 Section 420.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing § 420.33...

  17. 18 CFR 420.33 - Payment of bills.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Payment of bills. 420.33 Section 420.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing § 420.33...

  18. 18 CFR 420.33 - Payment of bills.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Payment of bills. 420.33 Section 420.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing § 420.33...

  19. 18 CFR 420.33 - Payment of bills.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Payment of bills. 420.33 Section 420.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing § 420.33...

  20. 18 CFR 420.33 - Payment of bills.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Payment of bills. 420.33 Section 420.33 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing § 420.33 Payment of...

  1. 31 CFR 3.3 - Legal review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF DEPARTMENT OF TREASURY EMPLOYEES Claims Under the Federal Tort Claims Act § 3.3 Legal review. Any... that is likely to result in multiple claimants, shall be forwarded to the legal division of the bureau... employee and the investigation, shall be reviewed in the legal division which shall thereupon make...

  2. 27 CFR 18.33 - Change in location.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Change in location. 18.33 Section 18.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Changes...

  3. 27 CFR 18.33 - Change in location.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Change in location. 18.33 Section 18.33 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS PRODUCTION OF VOLATILE FRUIT-FLAVOR CONCENTRATE Qualification Changes...

  4. 27 CFR 31.33 - Retail dealer in beer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Retail dealer in beer. 31... Classified § 31.33 Retail dealer in beer. (a) General. Except as otherwise provided in paragraph (b) of this section, every person who sells or offers for sale beer, but not distilled spirits or wines, to any...

  5. 27 CFR 31.33 - Retail dealer in beer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Retail dealer in beer. 31... Classified § 31.33 Retail dealer in beer. (a) General. Except as otherwise provided in paragraph (b) of this section, every person who sells or offers for sale beer, but not distilled spirits or wines, to any...

  6. 27 CFR 31.33 - Retail dealer in beer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Retail dealer in beer. 31... Classified § 31.33 Retail dealer in beer. (a) General. Except as otherwise provided in paragraph (b) of this section, every person who sells or offers for sale beer, but not distilled spirits or wines, to any...

  7. 27 CFR 31.33 - Retail dealer in beer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Retail dealer in beer. 31... Classified § 31.33 Retail dealer in beer. (a) General. Except as otherwise provided in paragraph (b) of this section, every person who sells or offers for sale beer, but not distilled spirits or wines, to any...

  8. 27 CFR 31.33 - Retail dealer in beer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Retail dealer in beer. 31... Classified § 31.33 Retail dealer in beer. (a) General. Except as otherwise provided in paragraph (b) of this section, every person who sells or offers for sale beer, but not distilled spirits or wines, to any...

  9. 33 CFR 64.31 - Determination of hazard to navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Determination of hazard to navigation. 64.31 Section 64.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARKING OF STRUCTURES, SUNKEN VESSELS AND OTHER OBSTRUCTIONS...

  10. 33 CFR 64.31 - Determination of hazard to navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Determination of hazard to navigation. 64.31 Section 64.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARKING OF STRUCTURES, SUNKEN VESSELS AND OTHER OBSTRUCTIONS...

  11. 33 CFR 64.31 - Determination of hazard to navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Determination of hazard to navigation. 64.31 Section 64.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARKING OF STRUCTURES, SUNKEN VESSELS AND OTHER OBSTRUCTIONS...

  12. 33 CFR 64.31 - Determination of hazard to navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Determination of hazard to navigation. 64.31 Section 64.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARKING OF STRUCTURES, SUNKEN VESSELS AND OTHER OBSTRUCTIONS...

  13. 33 CFR 64.31 - Determination of hazard to navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Determination of hazard to navigation. 64.31 Section 64.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO NAVIGATION MARKING OF STRUCTURES, SUNKEN VESSELS AND OTHER OBSTRUCTIONS...

  14. 33 CFR 161.18 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) PORTS AND WATERWAYS SAFETY VESSEL TRAFFIC MANAGEMENT Vessel Movement Reporting System § 161.18 Reporting... call. H HOTEL Date, time and point of entry system Entry time expressed as in (B) and into the...

  15. 18 CFR 806.31 - Term of approvals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Term of approvals. 806.31 Section 806.31 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION REVIEW AND APPROVAL OF PROJECTS Terms and Conditions of Approval § 806.31 Term of approvals. (a) Approvals issued under this part shall have a term...

  16. 30 CFR 18.31 - Enclosures-joints and fastenings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Enclosures-joints and fastenings. 18.31 Section... and Design Requirements § 18.31 Enclosures—joints and fastenings. (a) Explosion-proof enclosures: (1... square inch (gage). Castings shall be free from blowholes. (2) Welded joints forming an enclosure...

  17. 30 CFR 18.31 - Enclosures-joints and fastenings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Enclosures-joints and fastenings. 18.31 Section... and Design Requirements § 18.31 Enclosures—joints and fastenings. (a) Explosion-proof enclosures: (1... square inch (gage). Castings shall be free from blowholes. (2) Welded joints forming an enclosure...

  18. 30 CFR 18.31 - Enclosures-joints and fastenings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Enclosures-joints and fastenings. 18.31 Section... and Design Requirements § 18.31 Enclosures—joints and fastenings. (a) Explosion-proof enclosures: (1... square inch (gage). Castings shall be free from blowholes. (2) Welded joints forming an enclosure...

  19. 30 CFR 18.31 - Enclosures-joints and fastenings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Enclosures-joints and fastenings. 18.31 Section... and Design Requirements § 18.31 Enclosures—joints and fastenings. (a) Explosion-proof enclosures: (1... square inch (gage). Castings shall be free from blowholes. (2) Welded joints forming an enclosure...

  20. 30 CFR 18.31 - Enclosures-joints and fastenings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Enclosures-joints and fastenings. 18.31 Section... and Design Requirements § 18.31 Enclosures—joints and fastenings. (a) Explosion-proof enclosures: (1... square inch (gage). Castings shall be free from blowholes. (2) Welded joints forming an enclosure...

  1. 31 CFR 92.18 - Judicial review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE TREASURY UNITED STATES MINT OPERATIONS AND PROCEDURES Assessment of Civil Penalties for Misuse of Words, Letters, Symbols, or Emblems of the United States Mint § 92.18 Judicial review. A Final Notice...

  2. 31 CFR 92.18 - Judicial review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... THE TREASURY UNITED STATES MINT OPERATIONS AND PROCEDURES Assessment of Civil Penalties for Misuse of Words, Letters, Symbols, or Emblems of the United States Mint § 92.18 Judicial review. A Final Notice...

  3. 31 CFR 92.18 - Judicial review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THE TREASURY UNITED STATES MINT OPERATIONS AND PROCEDURES Assessment of Civil Penalties for Misuse of Words, Letters, Symbols, or Emblems of the United States Mint § 92.18 Judicial review. A Final Notice...

  4. 31 CFR 92.18 - Judicial review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... THE TREASURY UNITED STATES MINT OPERATIONS AND PROCEDURES Assessment of Civil Penalties for Misuse of Words, Letters, Symbols, or Emblems of the United States Mint § 92.18 Judicial review. A Final Notice...

  5. 31 CFR 18.1 - Designation of First Assistants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Designation of First Assistants. 18.1 Section 18.1 Money and Finance: Treasury Office of the Secretary of the Treasury OFFICIALS DESIGNATED TO PERFORM THE FUNCTIONS AND DUTIES OF CERTAIN OFFICES IN CASE OF ABSENCE, DISABILITY, OR VACANCY § 18.1 Designation of First Assistants. Except...

  6. 31 CFR 10.33 - Best practices for tax advisors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  7. 31 CFR 10.33 - Best practices for tax advisors.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  8. 31 CFR 10.33 - Best practices for tax advisors.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  9. 31 CFR 10.33 - Best practices for tax advisors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  10. 31 CFR 10.33 - Best practices for tax advisors.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  11. 33 CFR 401.31 - Meeting and passing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Meeting and passing. 401.31... passing. (a) The meeting and passing of vessels shall be governed by the Collision Regulations of Canada..., no vessel shall overtake and pass or attempt to overtake and pass another vessel— (1) In any...

  12. 33 CFR 181.31 - Manufacturer identification code assignment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manufacturer identification code... SECURITY (CONTINUED) BOATING SAFETY MANUFACTURER REQUIREMENTS Identification of Boats § 181.31 Manufacturer... request a manufacturer identification code in writing from the Recreational Boating Product...

  13. 18 CFR 430.31 - Sanctions: Civil and criminal.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Sanctions: Civil and criminal. 430.31 Section 430.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... the Commission may, in his discretion, request the appropriate law enforcement officers of...

  14. 18 CFR 430.31 - Sanctions: Civil and criminal.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Sanctions: Civil and criminal. 430.31 Section 430.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... the Commission may, in his discretion, request the appropriate law enforcement officers of...

  15. 18 CFR 430.31 - Sanctions: Civil and criminal.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Sanctions: Civil and criminal. 430.31 Section 430.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... the Commission may, in his discretion, request the appropriate law enforcement officers of...

  16. 18 CFR 420.31 - Certificate of entitlement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Certificate of entitlement. 420.31 Section 420.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing §...

  17. 18 CFR 420.31 - Certificate of entitlement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Certificate of entitlement. 420.31 Section 420.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-WATER SUPPLY CHARGES Entitlement; Measurement; Billing §...

  18. 18 CFR 3a.31 - Classification markings and special notations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Classification markings and special notations. 3a.31 Section 3a.31 Conservation of Power and Water Resources FEDERAL ENERGY... Confidential will be stamped in red ink, printed, or written in letters considerably larger than those used...

  19. 18 CFR 420.31 - Certificate of entitlement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Certificate of entitlement. (a) The Executive Director will issue to each known water user a certificate of... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Certificate of entitlement. 420.31 Section 420.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN...

  20. 18 CFR 420.31 - Certificate of entitlement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Certificate of entitlement. (a) The Executive Director will issue to each known water user a certificate of... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Certificate of entitlement. 420.31 Section 420.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN...

  1. 18 CFR 420.31 - Certificate of entitlement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Certificate of entitlement. (a) The Executive Director will issue to each known water user a certificate of... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Certificate of entitlement. 420.31 Section 420.31 Conservation of Power and Water Resources DELAWARE RIVER BASIN...

  2. 31 CFR 351.17-351.18 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false 351.17-351.18 Section 351.17-351.18 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES...

  3. 19 CFR 18.31 - Pipeline transportation of bonded merchandise.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Pipeline transportation of bonded merchandise. 18... Pipeline § 18.31 Pipeline transportation of bonded merchandise. (a) General. Merchandise may be transported by pipeline under the procedures in this part, as appropriate and unless otherwise...

  4. 19 CFR 18.31 - Pipeline transportation of bonded merchandise.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Pipeline transportation of bonded merchandise. 18... Pipeline § 18.31 Pipeline transportation of bonded merchandise. (a) General. Merchandise may be transported by pipeline under the procedures in this part, as appropriate and unless otherwise...

  5. 19 CFR 18.31 - Pipeline transportation of bonded merchandise.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Pipeline transportation of bonded merchandise. 18... Pipeline § 18.31 Pipeline transportation of bonded merchandise. (a) General. Merchandise may be transported by pipeline under the procedures in this part, as appropriate and unless otherwise...

  6. 19 CFR 18.31 - Pipeline transportation of bonded merchandise.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Pipeline transportation of bonded merchandise. 18... Pipeline § 18.31 Pipeline transportation of bonded merchandise. (a) General. Merchandise may be transported by pipeline under the procedures in this part, as appropriate and unless otherwise...

  7. 19 CFR 18.31 - Pipeline transportation of bonded merchandise.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Pipeline transportation of bonded merchandise. 18... Pipeline § 18.31 Pipeline transportation of bonded merchandise. (a) General. Merchandise may be transported by pipeline under the procedures in this part, as appropriate and unless otherwise...

  8. 31 CFR 223.18 - Performance of agency obligations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Performance of agency obligations. 223.18 Section 223.18 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE SURETY COMPANIES DOING...

  9. 18 CFR 33.5 - Proposed accounting entries.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail...

  10. 18 CFR 33.5 - Proposed accounting entries.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail...

  11. 18 CFR 33.5 - Proposed accounting entries.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail...

  12. 18 CFR 33.5 - Proposed accounting entries.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail...

  13. 18 CFR 33.5 - Proposed accounting entries.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail...

  14. 50 CFR 18.33 - Procedures for issuance of permits and modification, suspension, or revocation thereof.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Procedures for issuance of permits and modification, suspension, or revocation thereof. 18.33 Section 18.33 Wildlife and Fisheries UNITED STATES FISH... Exceptions § 18.33 Procedures for issuance of permits and modification, suspension, or revocation thereof....

  15. HI and Hα Mapping of M31 & M33

    NASA Astrophysics Data System (ADS)

    Kam, Z. S.; Carignan, C.; Chemin, L.; Hernandez, O.; de Denus-Baillargeon, M.; Djabo, Y.

    2011-12-01

    abstract-type="normal">RésuméWe performed a deep Hi and Hα mapping of M31 and M33 in order to get accurate kinematical data of those two galaxies and also to make a comparison between the Hi and Hα kinematics. The Hi data were obtained with the DRAO interferometer and the Hα data with the Fabry-Perot system of the Observatoire du mont Mégantic using an EMCCD as a detector. These data will give us the best possible datasets to derive accurate rotation curves and mass models for those two Local Group spirals and provide some new data for the Hii regions studies of these galaxies. While the Hi observations are of low resolution (~1 arcmin), the high resolution of the Hα data (~1 arcsec) should allow us to get much more details in the central regions, allowing at the same time a much better determination of the kinematical parameters. Hence, the inner part of the rotation curve, so inportant to constraint properly the mass models, will be determined more accurately.

  16. THE M31 VELOCITY VECTOR. III. FUTURE MILKY WAY M31-M33 ORBITAL EVOLUTION, MERGING, AND FATE OF THE SUN

    SciTech Connect

    Van der Marel, Roeland P.; Sohn, Sangmo Tony; Anderson, Jay; Besla, Gurtina; Cox, T. J.

    2012-07-01

    We study the future orbital evolution and merging of the Milky Way (MW)-M31-M33 system, using a combination of collisionless N-body simulations and semi-analytic orbit integrations. Monte Carlo simulations are used to explore the consequences of varying all relevant initial phase-space and mass parameters within their observational uncertainties. The observed M31 transverse velocity from Papers I and II implies that the MW and M31 will merge t = 5.86{sup +1.61}{sub -0.72} Gyr from now. The first pericenter occurs at t = 3.87{sup +0.42}{sub -0.32} Gyr, at a pericenter distance of r = 31.0{sup +38.0}{sub -19.8} kpc. In 41% of Monte Carlo orbits, M31 makes a direct hit with the MW, defined here as a first-pericenter distance less than 25 kpc. For the M31-M33 system, the first-pericenter time and distance are t = 0.85{sup +0.18}{sub -0.13} Gyr and r = 80.8{sup +42.2}{sub -31.7} kpc. By the time M31 gets to its first pericenter with the MW, M33 is close to its second pericenter with M31. For the MW-M33 system, the first-pericenter time and distance are t = 3.70{sup +0.74}{sub -0.46} Gyr and r = 176.0{sup +239.0}{sub -136.9} kpc. The most likely outcome is for the MW and M31 to merge first, with M33 settling onto an orbit around them that may decay toward a merger later. However, there is a 9% probability that M33 makes a direct hit with the MW at its first pericenter, before M31 gets to or collides with the MW. Also, there is a 7% probability that M33 gets ejected from the Local Group, temporarily or permanently. The radial mass profile of the MW-M31 merger remnant is significantly more extended than the original profiles of either the MW or M31, and suggests that the merger remnant will resemble an elliptical galaxy. The Sun will most likely ({approx}85% probability) end up at a larger radius from the center of the MW-M31 merger remnant than its current distance from the MW center, possibly further than 50 kpc ({approx}10% probability). There is a {approx}20

  17. 48 CFR 31.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... data specifically to support submitting a bid or proposal. Systems and other concept formulation... development and bid and proposal costs. 31.205-18 Section 31.205-18 Federal Acquisition Regulations System... Contracts With Commercial Organizations 31.205-18 Independent research and development and bid and...

  18. 48 CFR 31.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... data specifically to support submitting a bid or proposal. Systems and other concept formulation... development and bid and proposal costs. 31.205-18 Section 31.205-18 Federal Acquisition Regulations System... Contracts With Commercial Organizations 31.205-18 Independent research and development and bid and...

  19. 18 CFR 157.33 - Requirement for open season.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... season. 157.33 Section 157.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... GAS ACT Open Seasons for Alaska Natural Gas Transportation Projects § 157.33 Requirement for open season. (a) Any application for a certificate of public convenience and necessity or other...

  20. 18 CFR 157.33 - Requirement for open season.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... season. 157.33 Section 157.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... GAS ACT Open Seasons for Alaska Natural Gas Transportation Projects § 157.33 Requirement for open season. (a) Any application for a certificate of public convenience and necessity or other...

  1. 18 CFR 157.33 - Requirement for open season.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... season. 157.33 Section 157.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... GAS ACT Open Seasons for Alaska Natural Gas Transportation Projects § 157.33 Requirement for open season. (a) Any application for a certificate of public convenience and necessity or other...

  2. 18 CFR 157.33 - Requirement for open season.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... season. 157.33 Section 157.33 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... GAS ACT Open Seasons for Alaska Natural Gas Transportation Projects § 157.33 Requirement for open season. (a) Any application for a certificate of public convenience and necessity or other...

  3. Polymorphism of the capsid L1 gene of human papillomavirus types 31, 33, and 35.

    PubMed

    Cornut, Gilbert; Gagnon, Simon; Hankins, Catherine; Money, Deborah; Pourreaux, Karina; Franco, Eduardo L; Coutlée, François

    2010-07-01

    The L1 gene encodes for the major capsid protein of human papillomaviruses (HPV). There is limited information on the polymorphism of L1 for types related to HPV-16. This report explores the polymorphism of L1 in phylogenetically related types 31, 33, and 35 compared to HPV-16. Genital specimens collected from 732 HIV-seropositive and 323 HIV-seronegative women were screened for HPV DNA with consensus L1 PCR. Cervical samples positive for HPV-16 (n = 74), HPV-31 (n = 78), HPV-33 (n = 37), and HPV-35 (n = 58) were further characterized by PCR-sequencing of the complete L1 gene. The number of nucleotide substitutions within L1 ranged from 19 for HPV-33 to 52 for HPV-31. The ratio of the number of variants/number of isolates tested was higher for HPV-31 (56.4%, P = 0.05) and HPV-35 (60.3%, P = 0.04) compared to HPV-16 (40.5%), while this ratio was lower for HPV-33 (24.3%), although not significantly (P = 0.14). The maximal distance between HPV variants was greater in the five putative surface-exposed loops of L1 than in sequences outside the loops (P < 0.01). Synonymous variations were encountered in 1.7% (95% CI 1.1-2.3) of nucleotides inside the L1 loops and 2.4% (95% CI1.2-3.7) of nucleotides outside the L1 loops. Non-synonymous variations were encountered in 1.8% (95% CI 1.1-2.5) of nucleotides within the L1 loops and 0.2% (95% CI 0-0.4) of nucleotides outside the loops. dN/dS ratios were below 1.0 in extra-loop and intra-loop regions, but they were lower in extra-loop regions. These results suggest that sequences within and outside the hypervariable loops of L1 were under selective constraint.

  4. IL-31 and IL-33 circulating levels in allergic contact dermatitis.

    PubMed

    Guarneri, F; Minciullo, P L; Mannucci, C; Calapai, F; Saitta, S; Cannavò, S P; Gangemi, S

    2015-09-01

    Enhanced IL-31 expression in skin biopsies is present in allergic contact dermatitis (ACD). IL-33 expression is induced in keratinocytes and in skin of ACD patients. This overexpression is present in both allergic and irritant conditions. The aim of this work was to test the systemic involvement of IL-31 and IL-33 in ACD. IL-31 levels were significantly higher in patients than in controls. IL-33 serum levels, on the contrary, were similar in patients and controls. This work shows a possible systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 in ACD. IL-31 levels do not seem related to the allergen involved, and did not change on the strength of the allergen involved. More likely, IL-31 levels are related to the itch. IL-33, instead, is secreted from damaged or inflamed tissue and might function as an early warning system at the site of skin damage. In the future, IL-31 could be a possible therapeutic target of all pruritic skin diseases resistant to conventional therapies.

  5. 31 CFR 256.33 - For what period of time is interest computed under 31 U.S.C. 1304(b)?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false For what period of time is interest computed under 31 U.S.C. 1304(b)? 256.33 Section 256.33 Money and Finance: Treasury Regulations Relating to....33 For what period of time is interest computed under 31 U.S.C. 1304(b)? Interest is computed...

  6. 50 CFR 18.31 - Scientific research permits and public display permits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... display permits. 18.31 Section 18.31 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... the population stock and the marine ecosystem. In determining whether to issue a public display permit... question and the marine ecosystem on the other; and the applicant's qualifications for the proper care...

  7. 50 CFR 18.31 - Scientific research permits and public display permits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... display permits. 18.31 Section 18.31 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... the population stock and the marine ecosystem. In determining whether to issue a public display permit... question and the marine ecosystem on the other; and the applicant's qualifications for the proper care...

  8. 50 CFR 18.31 - Scientific research permits and public display permits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... display permits. 18.31 Section 18.31 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... the population stock and the marine ecosystem. In determining whether to issue a public display permit... question and the marine ecosystem on the other; and the applicant's qualifications for the proper care...

  9. 50 CFR 18.31 - Scientific research permits and public display permits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... display permits. 18.31 Section 18.31 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... the population stock and the marine ecosystem. In determining whether to issue a public display permit... question and the marine ecosystem on the other; and the applicant's qualifications for the proper care...

  10. 46 CFR 31.10-18 - Firefighting equipment: General-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... equipment shall be made: Table 31.10-18(b) Type unit Test Soda acid Discharge. Clean hose and inside of... made: Table 31.10-18(c) Type system Test Foam Systems utilizing a soda solution shall have such... for certification and the periodic inspection by discharging foam for approximately 15 seconds...

  11. 31 CFR 50.18 - Notice required by reinstatement provision.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion....

  12. 31 CFR 50.18 - Notice required by reinstatement provision.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion....

  13. 31 CFR 50.18 - Notice required by reinstatement provision.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion....

  14. 31 CFR 50.18 - Notice required by reinstatement provision.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RISK INSURANCE PROGRAM Disclosures as Conditions for Federal Payment § 50.18 Notice required by... property and casualty insurance that was in force on November 26, 2002, is void to the extent it excludes... and casualty insurance that was in force on November 26, 2002, and that excludes coverage for an...

  15. 33 CFR 137.18 - Duties of persons specified in § 137.1(a).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Duties of persons specified in § 137.1(a). 137.18 Section 137.18 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  16. 33 CFR 137.18 - Duties of persons specified in § 137.1(a).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Duties of persons specified in § 137.1(a). 137.18 Section 137.18 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  17. 33 CFR 137.18 - Duties of persons specified in § 137.1(a).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Duties of persons specified in § 137.1(a). 137.18 Section 137.18 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  18. 33 CFR 137.18 - Duties of persons specified in § 137.1(a).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Duties of persons specified in § 137.1(a). 137.18 Section 137.18 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  19. 33 CFR 137.18 - Duties of persons specified in § 137.1(a).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Duties of persons specified in § 137.1(a). 137.18 Section 137.18 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  20. 31 CFR 356.33 - Does the Treasury have any discretion in the auction process?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Does the Treasury have any discretion... CIRCULAR, PUBLIC DEBT SERIES NO. 1-93) Miscellaneous Provisions § 356.33 Does the Treasury have any discretion in the auction process? (a) We have the discretion to: (1) Accept, reject, or refuse to...

  1. Discrete clouds of neutral gas between the galaxies M31 and M33.

    PubMed

    Wolfe, Spencer A; Pisano, D J; Lockman, Felix J; McGaugh, Stacy S; Shaya, Edward J

    2013-05-09

    Spiral galaxies must acquire gas to maintain their observed level of star formation beyond the next few billion years. A source of this material may be the gas that resides between galaxies, but our understanding of the state and distribution of this gas is incomplete. Radio observations of the Local Group of galaxies have revealed hydrogen gas extending from the disk of the galaxy M31 at least halfway to M33. This feature has been interpreted to be the neutral component of a condensing intergalactic filament, which would be able to fuel star formation in M31 and M33, but simulations suggest that such a feature could also result from an interaction between both galaxies within the past few billion years (ref. 5). Here we report radio observations showing that about 50 per cent of this gas is composed of clouds, with the rest distributed in an extended, diffuse component. The clouds have velocities comparable to those of M31 and M33, and have properties suggesting that they are unrelated to other Local Group objects. We conclude that the clouds are likely to be transient condensations of gas embedded in an intergalactic filament and are therefore a potential source of fuel for future star formation in M31 and M33.

  2. Spectroscopy of luminous blue stars in M31 and M33

    SciTech Connect

    Humphreys, R.M.; Massey, P.; Freedman, W.L. Kitt Peak National Observatory, Tucson, AZ Mount Wilson and Las Campanas Observatories, Pasadena, CA )

    1990-01-01

    Spectra have been obtained for classification of 42 candidate supergiants and 12 probable OB stars in M31 and eight early-type stars in M33. Twenty-six of those in M31 and six in M33 are confirmed as apparent single members with spectral types ranging from O8 to F8. Their interstellar extinction and luminosities are derived from published photographic and CCD photometry for all of the confirmed members. The preliminary and still incomplete HR diagram obtained for M31 shows an apparent lack of the most massive stars, stars with initial masses greater than 60 solar masses. The effects of incompleteness and observational selection on the interpretation of this HR diagram are discussed. 42 refs.

  3. 18 CFR 131.31 - FERC Form No. 561, Annual report of interlocking positions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false FERC Form No. 561, Annual report of interlocking positions. 131.31 Section 131.31 Conservation of Power and Water Resources... regulations: enter in space 4 the complete FERC docket number of such authorization; enter in space 5...

  4. 26 CFR 31.3306(c)(18)-1 - Services of certain nonresident aliens.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 15 2012-04-01 2012-04-01 false Services of certain nonresident aliens. 31.3306...) § 31.3306(c)(18)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as a nonimmigrant...

  5. 26 CFR 31.3306(c)(18)-1 - Services of certain nonresident aliens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Services of certain nonresident aliens. 31.3306...) § 31.3306(c)(18)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as a nonimmigrant...

  6. 26 CFR 31.3306(c)(18)-1 - Services of certain nonresident aliens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Services of certain nonresident aliens. 31.3306...) § 31.3306(c)(18)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as a nonimmigrant...

  7. 26 CFR 31.3306(c)(18)-1 - Services of certain nonresident aliens.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Services of certain nonresident aliens. 31.3306...) § 31.3306(c)(18)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as a nonimmigrant...

  8. 26 CFR 31.3306(c)(18)-1 - Services of certain nonresident aliens.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Services of certain nonresident aliens. 31.3306...) § 31.3306(c)(18)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as a nonimmigrant...

  9. 18 CFR 4.31 - Initial or competing application: who may file.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Initial or competing application: who may file. 4.31 Section 4.31 Conservation of Power and Water Resources FEDERAL ENERGY... or a license for a water power project under Part I of the Federal Power Act. (b) Application...

  10. 18 CFR 4.31 - Initial or competing application: who may file.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Initial or competing application: who may file. 4.31 Section 4.31 Conservation of Power and Water Resources FEDERAL ENERGY... or a license for a water power project under Part I of the Federal Power Act. (b) Application...

  11. 18 CFR 4.31 - Initial or competing application: who may file.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Initial or competing application: who may file. 4.31 Section 4.31 Conservation of Power and Water Resources FEDERAL ENERGY... or a license for a water power project under Part I of the Federal Power Act. (b) Application...

  12. 18 CFR 4.31 - Initial or competing application: who may file.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Initial or competing application: who may file. 4.31 Section 4.31 Conservation of Power and Water Resources FEDERAL ENERGY... or a license for a water power project under Part I of the Federal Power Act. (b) Application...

  13. 18 CFR 4.31 - Initial or competing application: who may file.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Initial or competing application: who may file. 4.31 Section 4.31 Conservation of Power and Water Resources FEDERAL ENERGY... or a license for a water power project under Part I of the Federal Power Act. (b) Application...

  14. 31 CFR 103.18 - Reports by banks of suspicious transactions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... violations that require immediate attention, such as, for example, ongoing money laundering schemes, the bank... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Reports by banks of suspicious transactions. 103.18 Section 103.18 Money and Finance: Treasury Regulations Relating to Money and...

  15. Multiparticle-multihole states in 31Mg and 33Mg: A critical evaluation

    NASA Astrophysics Data System (ADS)

    Neyens, Gerda

    2011-12-01

    The experiments that provide information about the level structure of the “island of inversion” isotopes 31Mg and 33Mg are reviewed. Since the model-independent measurement of their ground-state spins was done, much experimental data can be reinterpreted, and spins and parities can be assigned to their excited states. Both experimental level schemes are found in very good agreement with calculations based on antisymmetrized molecular dynamics combined with the generator coordinate method. These calculations predict that both ground states are dominated by 2ℏω neutron excitations (more than 85% of the wave function). In the case of 33Mg, the energy of the 1ℏω and 3ℏω levels are calculated about 400 keV too high with respect to the ground state, while in 31Mg the 1ℏω levels are calculated only 200 keV too high. New key experiments are suggested.

  16. A Chinese patient with KBG syndrome and a 9q31.2-33.1 microdeletion.

    PubMed

    Xu, Mingzhi; Zhou, Huali; Yong, Jing; Cong, Peikuan; Li, Chengjiang; Yu, Yunsong; Qi, Ming

    2013-05-01

    KBG syndrome is characterized by postnatal short stature, macrodontia, facial and hand anomalies, delayed bone age and intellectual disability. KBG syndrome is an infrequently reported autosomal dominant condition caused by a mutation or haploinsufficiency of ANKRD11 at 16q24.3. We report on a patient, who showed many manifestations of KBG syndrome and was found to harbor a de novo ANKRD11 mutation, c.362T > A (p.Met121Lys). As the patient showed additional characteristics not occurring in KBG syndrome, a CGH array was performed which showed a de novo microdeletion of 9q31.2-q33.1. The majority of findings in our patient can be explained by the combined ANKRD11 mutation and 9q31.2-33.1 deletion. The case demonstrates well the need for comparing an abnormal genotype with a detailed phenotype analysis and the need for further studies in case the phenotype is unusual for the genotype.

  17. A search for globular clusters in more remote areas around M31 and M33 II

    SciTech Connect

    Di Tullio Zinn, Graziella; Zinn, Robert

    2014-04-01

    Using the Sloan Digital Sky Survey (SDSS), ∼900 deg{sup 2} of the sky surrounding M31 and M33 have been searched for globular clusters (GCs) that through galaxy interaction have become unbound from their parent systems and M31 (hence, intergalactic globular clusters, IGCs). This search reached a maximum of ∼500 kpc in projected galactocentric distance (R {sub gc}) from M31. Visual examination of 283,871 SDSS cutout images and of 1143 fits images yielded 320 candidates. This sample was reduced to six GCs and one likely candidate by excluding galaxies on the basis of combinations of their optical, ultraviolet, and infrared colors from the SDSS, the Galaxy Evolution Explorer satellite, and the Wide-field Infrared Survey Explorer satellite, as well as their photometric redshifts from the SDSS. Since these seven objects have 14 kpc ≤ R {sub gc} ≤ 137 kpc, they are more likely to be GCs in the halo of M31 than IGCs. They are all 'classical' as opposed to 'extended' GCs, and they provide further evidence that the remote halo of M31 (R {sub gc} ≥ 50 kpc) contains more GCs of all types and, in particular, far more 'classical' ones than the remote halo of the Milky Way.

  18. 48 CFR 31.205-18 - Independent research and development and bid and proposal costs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... research does not include efforts whose principal aim is design, development, or test of specific items or... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Independent research and... Contracts With Commercial Organizations 31.205-18 Independent research and development and bid and...

  19. 18 CFR 131.31 - FERC Form No. 561, Annual report of interlocking positions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, FEDERAL POWER ACT AND PUBLIC UTILITY REGULATORY POLICIES ACT OF 1978 FORMS § 131.31 FERC Form No. 561, Annual report of interlocking... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false FERC Form No....

  20. 18 CFR 131.31 - FERC Form No. 561, Annual report of interlocking positions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, FEDERAL POWER ACT AND PUBLIC UTILITY REGULATORY POLICIES ACT OF 1978 FORMS § 131.31 FERC Form No. 561, Annual report of interlocking... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false FERC Form No....

  1. 18 CFR 131.31 - FERC Form No. 561, Annual report of interlocking positions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY APPROVED FORMS, FEDERAL POWER ACT AND PUBLIC UTILITY REGULATORY POLICIES ACT OF 1978 FORMS § 131.31 FERC Form No. 561, Annual report of interlocking... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false FERC Form No....

  2. Clouds of neutral hydrogen between M31 and M33 and around the Milky Way

    NASA Astrophysics Data System (ADS)

    Wolfe, Spencer A.; Pisano, D. J.; Lockman, F. J.; McGaugh, S. S.; Shaya, E. J.

    2014-01-01

    Large spiral galaxies like our own Milky Way must acquire fresh gas to continue forming new stars. The gas that resides between galaxies may be a source of this material, but we know little about the gas’ structure or extent. I will present my thesis research, which attempts to answer these questions, based on our Green Bank Telescope (GBT) observations of the very faint M31-M33 neutral hydrogen (HI) stream that was first discovered a decade ago using the Westerbork Synthesis Radio Telescope. Our spectral line observations have over five times higher spatial resolution and roughly three times higher velocity resolution than the Westerbork data. These are the most sensitive observations of the 21 cm line conducted with the GBT. I will discuss our observing and reduction techniques used to reach the sensitivities needed to study the HI stream in detail. We find that the gas is actually composed of small clouds only a few kiloparsecs in diameter. The kinematics of the clouds also suggests that they are associated with M31 and M33 and not each galaxy’s respective High Velocity Cloud (HVC) population. Most, if not all, of the clouds do not appear to have stars associated with them. Thus, we believe that these clouds are part of a condensing intergalactic filament and may be a source of future star formation for M31 and M33. In addition, I will briefly present my research on the High Velocity and Intermediate Velocity Clouds around our Milky Way using the Galactic All-Sky Survey (GASS) at 21 cm that was conducted with the Parkes 64m radio telescope. I will discuss the basic properties of this gas and some interesting features seen in the survey.

  3. 31 CFR 50.33 - Entities that do not share profits and losses with private sector insurers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Entities that do not share profits and losses with private sector insurers. 50.33 Section 50.33 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM State Residual Market Insurance Entities;...

  4. 31 CFR 50.33 - Entities that do not share profits and losses with private sector insurers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Entities that do not share profits and losses with private sector insurers. 50.33 Section 50.33 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM State Residual Market Insurance Entities;...

  5. 31 CFR 50.33 - Entities that do not share profits and losses with private sector insurers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Entities that do not share profits and losses with private sector insurers. 50.33 Section 50.33 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM State Residual Market Insurance Entities;...

  6. Uv Observations of the Hubble-Sandage Variables in M31 and M33

    NASA Astrophysics Data System (ADS)

    Humphreys, Roberta

    1991-07-01

    The Hubble-Sandage variables in M31 and M33 are luminous blue variables (LBVs) -- very luminous, eruptively unstable stars in the same general class as S Dor, Eta Car, and P Cyg. UV observations of H-S variables will significantly enhance the limited information available to us concerning the evolution and structure of the most massive stars. ---- LBVs are important in several major astrophysical connections and are only beginning to be understood. Since the LBV stage of evolution is brief, only a few examples are available in our Galaxy and in the Magellanic Clouds, close enough for UV observations with IUE. Therefore our coverage of the wide parameter space embraced by LBVs has been so sparse that theoretical development has been hindered. ---- With the ST, we can significantly increase this coverage by adding the H-S variables in M31 and M33 to the set of "useful" LBVs. UV spectroscopy is needed to determine their temperatures, luminosities, and mass-loss rates. These parameters are required to clarify their relations to other LBVs and very massive stars in general, and to provide more information on evolutionary origin of LBVs, physical causes of the violent eruptions, and other problems.

  7. A Spectroscopic Survey of Massive Stars in M31 and M33

    NASA Astrophysics Data System (ADS)

    Massey, Philip; Neugent, Kathryn F.; Smart, Brianna M.

    2016-09-01

    We describe our spectroscopic follow-up to the Local Group Galaxy Survey (LGGS) photometry of M31 and M33. We have obtained new spectroscopy of 1895 stars, allowing us to classify 1496 of them for the first time. Our study has identified many foreground stars, and established membership for hundreds of early- and mid-type supergiants. We have also found nine new candidate luminous blue variables and a previously unrecognized Wolf-Rayet star. We republish the LGGS M31 and M33 catalogs with improved coordinates, and including spectroscopy from the literature and our new results. The spectroscopy in this paper is responsible for the vast majority of the stellar classifications in these two nearby spiral neighbors. The most luminous (and hence massive) of the stars in our sample are early-type B supergiants, as expected; the more massive O stars are more rare and fainter visually, and thus mostly remain unobserved so far. The majority of the unevolved stars in our sample are in the 20-40 M ⊙ range. The spectroscopic observations reported here were obtained at the MMT Observatory, a joint facility of the University of Arizona and the Smithsonian Institution. MMT telescope time was granted by NOAO, through the Telescope System Instrumentation Program (TSIP). TSIP is funded by the National Science Foundation. This paper uses data products produced by the OIR Telescope Data Center, supported by the Smithsonian Astrophysical Observatory.

  8. Corrosion-resistant amorphous metallic films of Mo49Cr33B18 alloy

    NASA Technical Reports Server (NTRS)

    Ramesham, R.; Distefano, S.; Fitzgerald, D.; Thakoor, A. P.; Khanna, S. K.

    1987-01-01

    Corrosion-resistant amorphous metallic alloy films of Mo49Cr33B18 with a crystallization temperature of 590 C were deposited onto glass and quartz substrates by magnetron sputter-quench technique. The amorphous nature of the films was confirmed by their diffuse X-ray diffraction patterns. The deposited films are densely packed (zone T) and exhibit low stress and good adhesion to the substrate. Corrosion current of as-deposited coating of MoCrB amorphous metallic alloy is approximately three orders of magnitude less than the corrosion current of 304 stainless steel in 1N H2SO4 solution.

  9. Familial vestibulocerebellar disorder maps to chromosome 13q31-q33: a new nystagmus locus

    PubMed Central

    Ragge, N; Hartley, C; Dearlove, A; Walker, J; Russell-Eggitt, I; Harris, C

    2003-01-01

    Design: Observational and experimental study. Methods: We carried out a phenotypic study of a unique four generation family with nystagmus. We performed genetic linkage studies including a genome wide search. Results: Affected family members developed vestibulocerebellar type nystagmus in the first two years of life. A higher incidence of strabismus was noted in affected members. Haplotype construction and analysis of recombination events linked the disorder to a locus (NYS4) on chromosome 13q31-q33 with a lod score of 6.322 at θ=0 for D13S159 and narrowed the region to a 13.8 cM region between markers D13S1300 and D13S158. Conclusions: This study suggests that the early onset acquired nystagmus seen in this family is caused by a single gene defect. Identification of the gene may hold the key to understanding pathways for early eye stabilisation and strabismus. PMID:12525540

  10. A VLA Search for Radio Signals from M31 and M33

    NASA Astrophysics Data System (ADS)

    Gray, Robert H.; Mooley, Kunal

    2017-03-01

    Observing nearby galaxies would facilitate the search for artificial radio signals by sampling several billions of stars simultaneously, but few efforts have been made to exploit this opportunity. An added attraction is that the Milky Way is the second largest member of the Local Group, so our galaxy might be a probable target for hypothetical broadcasters in nearby galaxies. We present the first relatively high spectral resolution (<1 kHz) 21 cm band search for intelligent radio signals of complete galaxies in the Local Group with the Jansky VLA, observing the galaxies M31 (Andromeda) and M33 (Triangulum)—the first and third largest members of the group, respectively—sampling more stars than any prior search of this kind. We used 122 Hz channels over a 1 MHz spectral window in the target galaxy velocity frame of reference, and 15 Hz channels over a 125 kHz window in our local standard of rest. No narrowband signals were detected above a signal-to-noise ratio of 7, suggesting the absence of continuous narrowband flux greater than approximately 0.24 and 1.33 Jy in the respective spectral windows illuminating our part of the Milky Way during our observations in 2014 December and 2015 January. This is also the first study in which the upgraded VLA has been used for SETI.

  11. Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils.

    PubMed

    Zen, Ke; Utech, Markus; Liu, Yuan; Soto, Illena; Nusrat, Asma; Parkos, Charles A

    2004-10-22

    The beta2 integrin CD11b/CD18 is an integral membrane protein that is present in the plasma membrane and secondary granules of neutrophils and functions as a major adhesion molecule. Upon cellular activation, there is translocation of intracellular pools of CD11b/CD18 to the plasma membrane in concert with enhanced cellular adhesion. Although much is known about the function of CD11b/CD18, how this protein is transported within the cell is less well defined. Here we report that CD11b/CD18 specifically binds to BAP31, a member of a novel class of sorting proteins regulating cellular anterograde transport. Through experiments aimed at identifying CD11b/CD18-binding proteins, we produced a monoclonal antibody termed E1B2 that recognizes a 28-kDa membrane protein that co-precipitates with CD11b/CD18. Microsequence analysis of the E1B2 antigen revealed that it is BAP31. Co-association of CD11b/CD18 and BAP31 was confirmed in co-immunoprecipitation and protein binding assays. Additional experiments revealed that the binding of BAP31 to CD11b/CD18 was not dependent on divalent cations nor mediated by the I-domain of CD11b. Using glutathione S-transferase fusion chimeras, we determined that binding of CD11b/CD18 to BAP31 is mediated through interactions with the cytoplasmic tail of BAP31. Immunolocalization studies revealed colocalization of BAP31 and CD11b/CD18 within neutrophil secondary granules. Subcellular fractionation studies in polymorphonuclear leukocytes (PMN) revealed similar patterns of redistribution of BAP31 and CD11b/CD18 from fractions enriched in secondary granules to the plasma membrane following stimulation with formylmethionylleucylphenylalanine (fMLP). Given the known sorting properties of BAP31, these findings suggest that BAP31 may play a role in regulating intracellular trafficking of CD11b/CD18 in neutrophils.

  12. 31 CFR 363.18 - Is Public Debt liable if the electronic transmission of my data is intercepted?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Securities Held in TreasuryDirect § 363.18 Is Public Debt liable if the electronic transmission of my data is... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Is Public Debt liable if the electronic transmission of my data is intercepted? 363.18 Section 363.18 Money and Finance:...

  13. Combined S-33 and O-18 Isotope Tracing of Intracellular Sulfur Metabolism during Microbial Sulfate Reduction

    NASA Astrophysics Data System (ADS)

    Antler, Gilad; Bosak, Tanja; Ono, Shuhei; Sivan, Orit; Turchyn, Alexandra V.

    2014-05-01

    Microbial sulfate reduction is a key player in the global carbon cycle, oxidizing nearly 50% of organic matter in marine sediments. The biochemical pathway of microbial sulfate reduction fractionates sulfur and oxygen isotopes and these fractionations can be used to reconstruct S cycling in sediments. Sulfur isotope fractionation during microbial sulfate reduction, which partitions lighter sulfur (32S) into sulfide and heavier sulfur (33S and 34S) into the residual sulfate, can be as high as 72o for 34S/32S. The availability and type of organic substrate control the magnitude of sulfur isotope fractionation by influencing the fluxes of and the transfer of electrons to different S species. The partitioning of oxygen in sulfate during microbial sulfate reduction appears to be strongly influenced by the oxygen isotopic composition of water in which the bacteria grow, but its magnitude also seems to correlate with the magnitude of 34S/32S isotope fractionation. In addition, the fractionation of 33S/32S is thought to reflect the reversibility of some intercellular fluxes. We wanted to investigate whether the 18O/16O, 34S/32S and 33S/32S isotope fractionations in sulfate are controlled by the same intracellular processes and conditions. This was done by investigating the combined sulfur and oxygen isotope partitioning by a marine Desulfovibrio sp. grown in pure culture on different organic substrates and in water with different isotopic composition of oxygen. The isotope fractionations of oxygen and sulfur correlated with the cell specific sulfate reduction rates (csSRR), where slower rates yielded higher sulfur fractionation (as high as 60) and higher oxygen isotope fractionation. The trends in 33S/32S and 34S/32S with the changing csSRR was similar to the trends in 18O/16O with the csSRR, suggesting that the same intercellular pathways controlled both oxygen and sulfur isotope signatures during microbial sulfate reduction. The use of water with different isotopic

  14. Ultraviolet spectroscopy of the brightest supergiants in M31 and M33

    NASA Technical Reports Server (NTRS)

    Humphreys, R. M.; Blaha, C.; Dodorico, S.; Gull, T. R.; Benevenuti, P.

    1983-01-01

    Ultraviolet spectroscopy from the IUE, in combination with groundbased visual and infrared photometry, are to determine the energy distributions of the luminous blue variables, the Hubble-Sandage variables, in M31 and M33. The observed energy distributions, especially in the ultraviolet, show that these stars are suffering interstellar reddening. When corrected for interstellar extinction, the integrated energy distributions yield the total luminosities and black body temperatures of the stars. The resulting bolometric magnitudes and temperatures confirm that these peculiar stars are indeed very luminous, hot stars. They occupy the same regions of the sub B01 vs. log T sub e diagram as do eta Car, P Cyg and S Dor in our galaxy and the LMC. Many of the Hubble-Sandage variables have excess infrared radiation which is attributed to free-free emission from their extended atmospheres. Rough mass loss estimates from the infrared excess yield rates of 0.00001 M sub annual/yr. The ultraviolet spectra of the H-S variables are also compared with similar spectra of eta Car, P Cyg and S For.

  15. 31 CFR 100.18 - Counterfeit notes to be marked; “redemption” of notes wrongfully so marked.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Counterfeit notes to be marked; âredemptionâ of notes wrongfully so marked. 100.18 Section 100.18 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY EXCHANGE OF PAPER CURRENCY...

  16. 31 CFR 100.18 - Counterfeit notes to be marked; “redemption” of notes wrongfully so marked.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Counterfeit notes to be marked; âredemptionâ of notes wrongfully so marked. 100.18 Section 100.18 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY EXCHANGE OF PAPER CURRENCY...

  17. A YAC contig of approximately 3 Mb from human chromosome 5q31 [yields] q33

    SciTech Connect

    Li, Xiang; Wang Jabs, E.; Hawkins, A.L.; Griffin, C.A. ); Wise, C.A.; Lovett, M. ); Le Paslier, D. ); Pittler, S.J. )

    1994-02-01

    The human chromosome 5q31-q33 region contains an interesting cluster of growth factor and receptor genes. In addition, several genetic disease loci have been localized within this region, but have not as yet been isolated as molecular clones. These include those loci involved in autosomal dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q-syndrome. A yeast artificial chromosome (YAC) contig of this region would assist in the further localization and isolation of these genes. The authors have used YACs isolated from the Washington University and Centre d'Etude du Polymorphisme Humain YAC libraries, including YACs from the large insert (mega) YAC library to build a contig greater than 3 Mb in size. An STS content strategy coupled with limited walking from YAC ends was used to isolate 22 overlapping YACs with as much as sixfold coverage. A total of 20 STSs, derived from genes, anonymous sequences, and vector Alu-PCR or inverse PCR products, were used to compile this contig. The order of loci, centromere-GRL-D5S207-D5S70-D5S545-D5S546-D5S547-D5S68-D5S548-D5S210-D5S549-D5S686- ADRB2-D5S559-CSF1R-D5S551-RPS14-D5S519-SPARC-telomere, was derived from the overlapping clones. This contig and clones derived from it will be useful substrates in selecting candidate cDNAs for the disease loci in this interval. 45 refs., 1 fig., 2 tabs.

  18. 33 CFR 117.31 - Drawbridge operations for emergency vehicles and emergency vessels.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... emergency vehicles and emergency vessels. 117.31 Section 117.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS General Requirements § 117.31... notice, or a proper signal as provided in § 117.15 of this part, the drawtender shall take all...

  19. The supernova progenitor mass distributions of M31 and M33: further evidence for an upper mass limit

    SciTech Connect

    Jennings, Zachary G.; Weisz, Daniel R.; Williams, Benjamin F.; Dalcanton, Julianne J.; Gilbert, Karoline M.; Fouesneau, Morgan; Murphy, Jeremiah W.; Dolphin, Andrew E. E-mail: adolphin@raytheon.com

    2014-11-10

    Using Hubble Space Telescope photometry to measure star formation histories, we age-date the stellar populations surrounding supernova remnants (SNRs) in M31 and M33. We then apply stellar evolution models to the ages to infer the corresponding masses for their supernova progenitor stars. We analyze 33 M33 SNR progenitors and 29 M31 SNR progenitors in this work. We then combine these measurements with 53 previously published M31 SNR progenitor measurements to bring our total number of progenitor mass estimates to 115. To quantify the mass distributions, we fit power laws of the form dN/dM∝M {sup –α}. Our new larger sample of M31 progenitors follows a distribution with α=4.4{sub −0.4}{sup +0.4}, and the M33 sample follows a distribution with α=3.8{sub −0.5}{sup +0.4}. Thus both samples are consistent within the uncertainties, and the full sample across both galaxies gives α=4.2{sub −0.3}{sup +0.3}. Both the individual and full distributions display a paucity of massive stars when compared to a Salpeter initial mass function, which we would expect to observe if all massive stars exploded as SN that leave behind observable SNR. If we instead fix α = 2.35 and treat the maximum mass as a free parameter, we find M {sub max} ∼ 35-45 M {sub ☉}, indicative of a potential maximum cutoff mass for SN production. Our results suggest that either SNR surveys are biased against finding objects in the youngest (<10 Myr old) regions, or the highest mass stars do not produce SNe.

  20. Comparison of the immunogenicity of Cervarix® and Gardasil® human papillomavirus vaccines for oncogenic non-vaccine serotypes HPV-31, HPV-33, and HPV-45 in HIV-infected adults.

    PubMed

    Toft, Lars; Tolstrup, Martin; Müller, Martin; Sehr, Peter; Bonde, Jesper; Storgaard, Merete; Østergaard, Lars; Søgaard, Ole S

    2014-01-01

    Individuals infected with human immunodeficiency virus (HIV) have excess risk of developing human papillomavirus (HPV)-related disease. A substantial fraction of HPV-associated cancers is caused by HPV serotypes not included in the currently available vaccines. Among healthy women, both Cervarix(®) (HPV-16/18, GlaxoSmithKline Biologicals, GSK) and Gardasil(®) (HPV-6/11/16/18, Merck) have demonstrated partial cross-protection against certain oncogenic non-vaccine HPV-types. Currently, there are no available data on vaccine-induced cross-protection in men and little is known about cross-reactive immunity after HPV-vaccination of HIV-infected individuals. In an investigator-initiated trial, we randomized 91 HIV-positive men and women to receive vaccination with Cervarix(®) or Gardasil(®). The HPV-DNA status of the participants was determined with pcr before and after immunization. Cross-reactive antibody responses against HPV-31, HPV-33, and HPV-45 were evaluated for up to 12 months using a pseudovirion-based neutralization assay (PBNA). Geometric mean antibody titers (GMTs) were compared among vaccine groups and genders at 7 and 12 months.: Both vaccines induced anti-HPV-31, -33, and -45 neutralizing antibodies in participants who were seronegative and HPV-DNA negative for those types at study entry. Geometric mean antibody titers were comparable between vaccine groups. Interestingly, anti-HPV-31 and -33 antibody titers were higher among women compared with men at 7 and 12 months.: In conclusion, both licensed HPV-vaccines induced cross-neutralizing antibodies against frequent oncogenic non-vaccine serotypes HPV-31, HPV-33, and HPV-45 in HIV-infected adults, and women had greater serological responses against HPV-31 and -33 compared with men.

  1. Flight Demonstration of X-33 Vehicle Health Management System Components on the F/A-18 Systems Research Aircraft

    NASA Technical Reports Server (NTRS)

    Schweikhard, Keith A.; Richards, W. Lance; Theisen, John; Mouyos, William; Garbos, Raymond; Schkolnik, Gerald (Technical Monitor)

    1998-01-01

    The X-33 reusable launch vehicle demonstrator has identified the need to implement a vehicle health monitoring system that can acquire data that monitors system health and performance. Sanders, a Lockheed Martin Company, has designed and developed a commercial off-the-shelf (COTS)-based open architecture system that implements a number of technologies that have not been previously used in a flight environment. NASA Dryden Flight Research Center and Sanders teamed to demonstrate that the distributed remote health nodes, fiber optic distributed strain sensor, and fiber distributed data interface communications components of the X-33 vehicle health management (VHM) system could be successfully integrated and flown on a NASA F-18 aircraft. This paper briefly describes components of X-33 VHM architecture flown at Dryden and summarizes the integration and flight demonstration of these X-33 VHM components. Finally, it presents early results from the integration and flight efforts.

  2. Flight Demonstration of X-33 Vehicle Health Management System Components on the F/A-18 Systems Research Aircraft

    NASA Technical Reports Server (NTRS)

    Schweikhard, Keith A.; Richards, W. Lance; Theisen, John; Mouyos, William; Garbos, Raymond

    2001-01-01

    The X-33 reusable launch vehicle demonstrator has identified the need to implement a vehicle health monitoring system that can acquire data that monitors system health and performance. Sanders, a Lockheed Martin Company, has designed and developed a COTS-based open architecture system that implements a number of technologies that have not been previously used in a flight environment. NASA Dryden Flight Research Center and Sanders teamed to demonstrate that the distributed remote health nodes, fiber optic distributed strain sensor, and fiber distributed data interface communications components of the X-33 vehicle health management (VHM) system could be successfully integrated and flown on a NASA F-18 aircraft. This paper briefly describes components of X-33 VHM architecture flown at Dryden and summarizes the integration and flight demonstration of these X-33 VHM components. Finally, it presents early results from the integration and flight efforts.

  3. 31 CFR 103.33 - Records to be made and retained by financial institutions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... enforcement or financial regulatory agency, or in connection with the requesting financial institution's own... financial institutions. 103.33 Section 103.33 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING AND REPORTING OF CURRENCY AND FOREIGN TRANSACTIONS Records Required To...

  4. Observations of M31 and M33 with the Fermi Large Area Telescope: A Galactic Center Excess in Andromeda?

    NASA Astrophysics Data System (ADS)

    Ackermann, M.; Ajello, M.; Albert, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Cameron, R. A.; Caputo, R.; Caragiulo, M.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Chiaro, G.; Ciprini, S.; Costanza, F.; Cutini, S.; D’Ammando, F.; de Palma, F.; Desiante, R.; Digel, S. W.; Di Lalla, N.; Di Mauro, M.; Di Venere, L.; Favuzzi, C.; Funk, S.; Fusco, P.; Gargano, F.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Green, D.; Grenier, I. A.; Guillemot, L.; Guiriec, S.; Hayashi, K.; Hou, X.; Jóhannesson, G.; Kamae, T.; Knödlseder, J.; Kong, A. K. H.; Kuss, M.; La Mura, G.; Larsson, S.; Latronico, L.; Li, J.; Longo, F.; Loparco, F.; Lubrano, P.; Maldera, S.; Malyshev, D.; Manfreda, A.; Martin, P.; Mazziotta, M. N.; Michelson, P. F.; Mirabal, N.; Mitthumsiri, W.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Negro, M.; Nuss, E.; Ohsugi, T.; Omodei, N.; Orlando, E.; Ormes, J. F.; Paneque, D.; Persic, M.; Pesce-Rollins, M.; Piron, F.; Porter, T. A.; Principe, G.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, O.; Sánchez-Conde, M.; Sgrò, C.; Simone, D.; Siskind, E. J.; Spada, F.; Spandre, G.; Spinelli, P.; Tanaka, K.; Tibaldo, L.; Torres, D. F.; Troja, E.; Uchiyama, Y.; Wang, J. C.; Wood, K. S.; Wood, M.; Zaharijas, G.; Zhou, M.

    2017-02-01

    The Fermi Large Area Telescope (LAT) has opened the way for comparative studies of cosmic rays (CRs) and high-energy objects in the Milky Way (MW) and in other, external, star-forming galaxies. Using 2 yr of observations with the Fermi LAT, Local Group galaxy M31 was detected as a marginally extended gamma-ray source, while only an upper limit has been derived for the other nearby galaxy M33. We revisited the gamma-ray emission in the direction of M31 and M33 using more than 7 yr of LAT Pass 8 data in the energy range 0.1{--}100 {GeV}, presenting detailed morphological and spectral analyses. M33 remains undetected, and we computed an upper limit of 2.0× {10}-12 {erg} {{cm}}-2 {{{s}}}-1 on the 0.1{--}100 {GeV} energy flux (95% confidence level). This revised upper limit remains consistent with the observed correlation between gamma-ray luminosity and star formation rate tracers and implies an average CR density in M33 that is at most half of that of the MW. M31 is detected with a significance of nearly 10σ . Its spectrum is consistent with a power law with photon index {{Γ }}=2.4+/- {0.1}{stat+{syst}} and a 0.1{--}100 {GeV} energy flux of (5.6+/- {0.6}{stat+{syst}})× {10}-12 {erg} {{cm}}-2 {{{s}}}-1. M31 is detected to be extended with a 4σ significance. The spatial distribution of the emission is consistent with a uniform-brightness disk with a radius of 0.°4 and no offset from the center of the galaxy, but nonuniform intensity distributions cannot be excluded. The flux from M31 appears confined to the inner regions of the galaxy and does not fill the disk of the galaxy or extend far from it. The gamma-ray signal is not correlated with regions rich in gas or star formation activity, which suggests that the emission is not interstellar in origin, unless the energetic particles radiating in gamma rays do not originate in recent star formation. Alternative and nonexclusive interpretations are that the emission results from a population of millisecond pulsars

  5. 33 CFR 117.31 - Drawbridge operations for emergency vehicles and emergency vessels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... emergency vehicle is responding to an emergency situation, a drawtender must make all reasonable efforts to... following, provided this opening does not conflict with local emergency management procedures which have... emergency vehicles and emergency vessels. 117.31 Section 117.31 Navigation and Navigable Waters COAST...

  6. Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

    PubMed

    McMahon, Anne; Fowler, Stephen C; Perney, Teresa M; Akemann, Walther; Knöpfel, Thomas; Joho, Rolf H

    2004-06-01

    Double-mutant mice (DKO) lacking the two voltage-gated K(+) channels Kv3.1 and Kv3.3 display a series of phenotypic alterations that include ataxia, myoclonus, tremor and alcohol hypersensitivity. The prominent cerebellar expression of mRNAs encoding Kv3.1 and Kv3.3 subunits raised the question as to whether altered electrical activity resulting from the lack of these K(+) channels might be related to the dramatic motor changes. We used the tremorogenic agent harmaline to probe mutant mice lacking different K(+) channel alleles for altered olivocerebellar circuit properties. Harmaline induced the characteristic 13-Hz tremor in wildtype mice (WT); however, no tremor was observed in DKO suggesting that the ensemble properties of the olivocerebellar circuitry are altered in the absence of Kv3.1 and Kv3.3 subunits. Harmaline induced tremor in Kv3.1-single mutants, but it was of smaller amplitude and at a lower frequency indicating the participation of Kv3.1 subunits in normal olivocerebellar system function. In contrast, harmaline tremor was virtually absent in Kv3.3-single mutants indicating an essential role for Kv3.3 subunits in tremor induction by harmaline. Immunohistochemical staining for Kv3.3 showed clear expression in the somata and proximal dendrites of Purkinje cells and in their axonal projections to the deep cerebellar nuclei (DCN). In DCN, both Kv3.1 and Kv3.3 subunits are expressed. Action potential duration is increased by approximately 100% in Purkinje cells from Kv3.3-single mutants compared to WT or Kv3.1-single mutants. We conclude that Kv3.3 channel subunits are essential for the olivocerebellar system to generate and sustain normal harmaline tremor whereas Kv3.1 subunits influence tremor amplitude and frequency.

  7. VizieR Online Data Catalog: Revised LGGS UBVRI photometry of M31 and M33 stars (Massey+, 2016)

    NASA Astrophysics Data System (ADS)

    Massey, P.; Neugent, K. F.; Smart, B. M.

    2016-09-01

    The Local Group Galaxy Survey (LGGS) provides UBVRI plus interference-image photometry of luminous stars in the spiral galaxies M31 and M33, along with those found in seven dwarf systems currently forming massive stars (IC 10, NGC 6822, WLM, Sextans A and B, Pegasus, and Phoenix) with the intent of serving as a starting point for systematic exploration of the stellar content of our nearest neighbors beyond the Magellanic Clouds (MCs; Massey et al. 2006, Cat. J/AJ/131/2478; Massey ey al. 2007, Cat. J/AJ/134/2474; Massey et al. 2007, Cat. J/AJ/133/2393; Massey et al. 2011AJ....141...28M). All of the observations on which our new spectroscopy is based come from the 6.5m MMT telescope used with the 300 fiber positioner Hectospec. This instrument provides a 1° field-of-view, with a choice of two gratings: (1) a 270 line/mm blazed at 5000Å, which covers the entire visible region (3650-9200Å) at once with a resolution of ~5Å, and (2) a 600 line/mm grating blazed 6000Å, which covers 2300Å at one time at a resolution of ~2Å. The fibers have a diameter of 1.5''. The majority of the new observations reported here were obtained with the higher dispersion grating nominally centered at 4800Å but actually covering 3700-6000Å. Some additional new spectral types are those of the Wolf-Rayet stars (non-WRs) found by Neugent & Massey 2011 (Cat. J/ApJ/733/123) and Neugent et al. 2012 (Cat. J/ApJ/759/11); these data were obtained with the lower-dispersion grating, with details reported in that paper. The first year of observations were obtained during the Fall of 2009, with nominally three nights assigned (2009B-0149), but poor weather during the semester meant we obtained only four fields in M31 and one field in M33. Each observation consisted of 3*45 minute exposures. The second year (Fall 2010), two nights were nominally assigned (NOAO 2010B-0260), allowing us to observe three additional fields in M33, two with 3*45 minute exposures and one with 3*40 minute exposures. We

  8. Variant-specific persistence of infections with human papillomavirus Types 31, 33, 45, 56 and 58 and risk of cervical intraepithelial neoplasia.

    PubMed

    Xi, Long Fu; Schiffman, Mark; Koutsky, Laura A; Hughes, James P; Hulbert, Ayaka; Shen, Zhenping; Galloway, Denise A; Kiviat, Nancy B

    2016-09-01

    In our previous study of the etiologic role of oncogenic human papillomavirus (HPV) types other than HPV16 and 18, we observed a significantly higher risk of cervical intraepithelial neoplasia Grades 2-3 (CIN2/3) associated with certain lineages of HPV types 31/33/45/56/58 [called high-risk (HR) variants] compared with non-HR variants. This study was to examine whether these intra-type variants differ in persistence of the infection and persistence-associated risk of CIN2/3. Study subjects were women who had any of HPV types 31/33/45/56/58 newly detected during a 2-year follow-up with 6-month intervals. For each type, the first positive sample was used for variant characterization. The association of reverting-to-negativity with group of the variants and CIN2/3 with length of positivity was assessed using discrete Cox regression and logistic regression, respectively. Of the 598 newly detected, type-specific HPV infections, 312 became undetectable during follow-up. Infections with HR, compared with non-HR, variants were marginally more likely to become negative [adjusted hazard ratio = 1.3; 95% confidence interval (CI), 0.9-1.8]. The adjusted odds ratio associating with the development of CIN2/3 was 3.0 (95% CI, 1.2-7.4) for persistent infections with HR variants for 6 months and 10.0 (95% CI, 3.8-38.0) for persistent infections with HR variants for 12-18 months as compared with the first positive detection of HR variants. Among women with non-HR variants, there were no appreciable differences in risk of CIN2/3 by length of positivity. Findings suggest that the lineage-associated risk of CIN2/3 was not mediated through a prolonged persistent infection, but oncogenic heterogeneity of the variants.

  9. IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.

    PubMed

    Meyer, Christian G; Calixto Fernandes, Maria H; Intemann, Christopher D; Kreuels, Benno; Kobbe, Robin; Kreuzberg, Christina; Ayim, Matilda; Ruether, Andreas; Loag, Wibke; Ehmen, Christa; Adjei, Samuel; Adjei, Ohene; Horstmann, Rolf D; May, Jürgen

    2011-03-15

    Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31-33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have not yet been identified for this chromosomal region. In order to perform association analyses of 5q31-33 locus candidate single nucleotide polymorphisms (SNPs), 1015 children were recruited at the age of 3 months and followed monthly until the age of 2 years in an area holoendemic for Plasmodium falciparum malaria in Ghana. Quantitative (incidence rates of malaria episodes) and qualitative phenotypes (i.e. 'more than one malaria episode' or 'not more than one malaria episode') were used in population- and family-based analyses. The strongest signal was observed for the interleukin 3 gene (IL3) SNP rs40401 (P = 3.4 × 10(-7), P(c)= 1.4 × 10(-4)). The IL3 genotypes rs40401(CT) and rs40401(TT) were found to exert a protective effect of 25% [incidence rate ratio (IRR) 0.75, P = 4.1 × 10(-5)] and 33% (IRR 0.67, P = 3.2 × 10(-8)), respectively, against malaria attacks. The association was confirmed in transmission disequilibrium tests (TDT, qTDT). The results could argue for a role of IL3 in the pathophysiology of falciparum malaria.

  10. 33 CFR 89.18 - Record of certification of vessels of special construction or purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Coast Guard vessels are available for inspection at the offices of Assistant Commandant for Marine... vessels of special construction or purpose. 89.18 Section 89.18 Navigation and Navigable Waters COAST... RULES Certificate of Alternative Compliance § 89.18 Record of certification of vessels of...

  11. 33 CFR 89.18 - Record of certification of vessels of special construction or purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Coast Guard vessels are available for inspection at the offices of Assistant Commandant for Marine... vessels of special construction or purpose. 89.18 Section 89.18 Navigation and Navigable Waters COAST... RULES Certificate of Alternative Compliance § 89.18 Record of certification of vessels of...

  12. Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3.

    PubMed

    Matsukawa, Hiroshi; Wolf, Alexander M; Matsushita, Shinichi; Joho, Rolf H; Knöpfel, Thomas

    2003-08-20

    Micelacking both Kv3.1 and both Kv3.3 K+ channel alleles display severe motor deficits such as tremor, myoclonus, and ataxic gait. Micelacking one to three alleles at the Kv3.1 and Kv3.3 loci exhibit in an allele dose-dependent manner a modest degree of ataxia. Cerebellar granule cells coexpress Kv3.1 and Kv3.3 K+ channels and are therefore candidate neurons that might be involved in these behavioral deficits. Hence, we investigated the synaptic mechanisms of transmission in the parallel fiber-Purkinje cell system. Action potentials of parallel fibers were broader in mice lacking both Kv3.1 and both Kv3.3 alleles and in mice lacking both Kv3.1 and a single Kv3.3 allele compared with those of wild-type mice. The transmission of high-frequency trains of action potentials was only impaired at 200 Hz but not at 100 Hz in mice lacking both Kv3.1 and Kv3.3 genes. However, paired-pulse facilitation (PPF) at parallel fiber-Purkinje cell synapses was dramatically reduced in a gene dose-dependent manner in mice lacking Kv3.1 or Kv3.3 alleles. Normal PPF could be restored by reducing the extracellular Ca2+ concentration indicating that increased activity-dependent presynaptic Ca2+ influx, at least in part caused the altered PPF in mutant mice. Induction of metabotropic glutamate receptor-mediated EPSCs was facilitated, whereas longterm depression was not impaired but rather facilitated in Kv3.1/Kv3.3 double-knockout mice. These results demonstrate the importance of Kv3 potassium channels in regulating the dynamics of synaptic transmission at the parallel fiber-Purkinje cell synapse and suggest a correlation between short-term plasticity at the parallel fiber-Purkinje cell synapse and motor performance.

  13. 33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Hull, Mass. (a) Area No. 1 in Allerton Harbor. That area north of Hog Island beginning at latitude 42°18′15″, longitude 70°53′46″; thence due east to latitude 42°18′15″, longitude 70°53′29.5″; thence due south to latitude 42°18′07.5″, longitude 70°53′29.5″; thence due west to latitude 42°18′07.5″,...

  14. 33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Hull, Mass. (a) Area No. 1 in Allerton Harbor. That area north of Hog Island beginning at latitude 42°18′15″, longitude 70°53′46″; thence due east to latitude 42°18′15″, longitude 70°53′29.5″; thence due south to latitude 42°18′07.5″, longitude 70°53′29.5″; thence due west to latitude 42°18′07.5″,...

  15. 33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Hull, Mass. (a) Area No. 1 in Allerton Harbor. That area north of Hog Island beginning at latitude 42°18′15″, longitude 70°53′46″; thence due east to latitude 42°18′15″, longitude 70°53′29.5″; thence due south to latitude 42°18′07.5″, longitude 70°53′29.5″; thence due west to latitude 42°18′07.5″,...

  16. 33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Hull, Mass. (a) Area No. 1 in Allerton Harbor. That area north of Hog Island beginning at latitude 42°18′15″, longitude 70°53′46″; thence due east to latitude 42°18′15″, longitude 70°53′29.5″; thence due south to latitude 42°18′07.5″, longitude 70°53′29.5″; thence due west to latitude 42°18′07.5″,...

  17. 33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Hull, Mass. (a) Area No. 1 in Allerton Harbor. That area north of Hog Island beginning at latitude 42°18′15″, longitude 70°53′46″; thence due east to latitude 42°18′15″, longitude 70°53′29.5″; thence due south to latitude 42°18′07.5″, longitude 70°53′29.5″; thence due west to latitude 42°18′07.5″,...

  18. VizieR Online Data Catalog: Variable stars in M31 & M33. II. LBVs (Humphreys+, 2014)

    NASA Astrophysics Data System (ADS)

    Humphreys, R. M.; Weis, K.; Davidson, K.; Bomans, D. J.; Burggraf, B.

    2016-08-01

    In Paper I (Humphreys et al. 2013ApJ...773...46H), we discussed a small group of intermediate temperature supergiants, the warm hypergiants, and suggested that they were likely post-red supergiants. In this second paper, we review the spectral characteristics, spectral energy distributions (SEDs), circumstellar ejecta, and mass loss of the LBVs, candidate LBVs, emission line stars, and other luminous and variable stars in M31 and M33. The observations (described in paper I) were made in 2010 October with the Hectospec Multi-Object Spectrograph on the 6.5m MMT on Mount Hopkins. A few stars of special interest (5 in M31 and 8 in M33) were also observed with the MODS1 spectrograph on the Large Binocular Telescope (LBT) during commissioning in 2011 September, and in 2012 October and November, and 2013 January. All of the stars for which we have spectra are listed in Table 1 in order of right ascension. (2 data files).

  19. Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones.

    PubMed

    Nowak, A; Mathieson, H R; Chapman, R J; Janzsó, G; Yanagawa, Y; Obata, K; Szabo, G; King, A E

    2011-09-01

    GABAergic interneurones, including those within spinal dorsal horn, contain one of the two isoforms of the synthesizing enzyme glutamate decarboxylase (GAD), either GAD65 or GAD67. The physiological significance of these two GABAergic phenotypes is unknown but a more detailed anatomical and functional characterization may help resolve this issue. In this study, two transgenic Green Fluorescent Protein (GFP) knock-in murine lines, namely GAD65-GFP and GAD67-GFP (Δneo) mice, were used to profile expression of Shaw-related Kv3.1b and Kv3.3 K(+)-channel subunits in dorsal horn interneurones. Neuronal expression of these subunits confers specific biophysical characteristic referred to as 'fast-spiking'. Immuno-labelling for Kv3.1b or Kv3.3 revealed the presence of both of these subunits across the dorsal horn, most abundantly in laminae I-III. Co-localization studies in transgenic mice indicated that Kv3.1b but not Kv3.3 was associated with GAD65-GFP and GAD67-GFP immunopositive neurones. For comparison the distributions of Kv4.2 and Kv4.3 K(+)-channel subunits which are linked to an excitatory neuronal phenotype were characterized. No co-localization was found between GAD-GFP +ve neurones and Kv4.2 or Kv4.3. In functional studies to evaluate whether either GABAergic population is activated by noxious stimulation, hindpaw intradermal injection of capsaicin followed by c-fos quantification in dorsal horn revealed co-expression c-fos and GAD65-GFP (quantified as 20-30% of GFP +ve population). Co-expression was also detected for GAD67-GFP +ve neurones and capsaicin-induced c-fos but at a much reduced level of 4-5%. These data suggest that whilst both GAD65-GFP and GAD67-GFP +ve neurones express Kv3.1b and therefore may share certain biophysical traits, their responses to peripheral noxious stimulation are distinct.

  20. The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin.

    PubMed

    Conn, Kristen L; Hendzel, Michael J; Schang, Luis M

    2013-01-01

    During lytic infections, HSV-1 genomes are assembled into unstable nucleosomes. The histones required for HSV-1 chromatin assembly, however, are in the cellular chromatin. We have shown that linker (H1) and core (H2B and H4) histones are mobilized during HSV-1 infection, and proposed that the mobilized histones are available for assembly into viral chromatin. However, the actual relevance of histone mobilization remained unknown. We now show that canonical H3.1 and variant H3.3 are also mobilized during HSV-1 infection. Mobilization required no HSV-1 protein expression, although immediate early or early proteins enhanced it. We used the previously known differential association of H3.3 and H3.1 with HSV-1 DNA to test the relevance of histone mobilization. H3.3 binds to HSV-1 genomes first, whereas H3.1 only binds after HSV-1 DNA replication initiates. Consistently, H3.3 and H3.1 were differentially mobilized. H3.1 mobilization decreased with HSV-1 DNA replication, whereas H3.3 mobilization was largely unaffected by it. These results support a model in which previously mobilized H3.1 is immobilized by assembly into viral chromatin during HSV-1 DNA replication, whereas H3.3 is mobilized and assembled into HSV-1 chromatin throughout infection. The differential mobilizations of H3.3 and H3.1 are consistent with their differential assembly into viral chromatin. These data therefore relate nuclear histone dynamics to the composition of viral chromatin and provide the first evidence that histone mobilization relates to viral chromatin assembly.

  1. Combined 34S, 33S and 18O isotope fractionations record different intracellular steps of microbial sulfate reduction

    NASA Astrophysics Data System (ADS)

    Antler, Gilad; Turchyn, Alexandra V.; Ono, Shuhei; Sivan, Orit; Bosak, Tanja

    2017-04-01

    Several enzymatic steps in microbial sulfate reduction (MSR) fractionate the isotope ratios of 33S/32S, 34S/32S and 18O/16O in extracellular sulfate, but the effects of different intracellular processes on the isotopic composition of residual sulfate are still not well quantified. We measured combined multiple sulfur (33S/32S, 34S/32S) and oxygen (18O/16O) isotope ratios of sulfate in pure cultures of a marine sulfate reducing bacterium Desulfovibrio sp. DMSS-1 grown on different organic substrates. These measurements are consistent with the previously reported correlations of oxygen and sulfur isotope fractionations with the cell-specific rate of MSR: faster reduction rates produced smaller isotopic fractionations for all isotopes. Combined isotope fractionation of oxygen and multiple sulfur isotopes are also consistent with the relationship between the rate limiting step during microbial sulfate reduction and the availability of the DsrC subunit. These experiments help reconstruct and interpret processes that operate in natural pore waters characterized by high 18O/16O and moderate 34S/32S ratios and suggest that some multiple isotope signals in the environment cannot be explained by microbial sulfate reduction alone. Instead, these signals support the presence of active, but slow sulfate reduction as well as the reoxidation of sulfide.

  2. 18 CFR 33.3 - Additional information requirements for applications involving horizontal competitive impacts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... reserve existing transmission capacity needed for native load growth and network transmission...

  3. 18 CFR 33.3 - Additional information requirements for applications involving horizontal competitive impacts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... reserve existing transmission capacity needed for native load growth and network transmission...

  4. 18 CFR 33.3 - Additional information requirements for applications involving horizontal competitive impacts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... reserve existing transmission capacity needed for native load growth and network transmission...

  5. 18 CFR 33.4 - Additional information requirements for applications involving vertical competitive impacts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... entities that provides inputs to electricity products and one or more merging entities that...

  6. 18 CFR 33.4 - Additional information requirements for applications involving vertical competitive impacts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... entities that provides inputs to electricity products and one or more merging entities that...

  7. 18 CFR 33.4 - Additional information requirements for applications involving vertical competitive impacts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Additional information... and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE... entities that provides inputs to electricity products and one or more merging entities that...

  8. Characterization of apple 18 and 31 kd allergens by microsequencing and evaluation of their content during storage and ripening.

    PubMed

    Hsieh, L S; Moos, M; Lin, Y

    1995-12-01

    Patients with tree pollinosis frequently report allergic reactions after ingestion of apples. The severity of apple allergy has been related to the variety of apples and their degree of maturity. To generate a serum pool that is representative of various IgE-binding patterns of apple-allergic sera, serum samples from 34 patients allergic to tree pollens were screened. Only 24 serum samples reacted to the apple extract. Pooled serum was used to identify allergens in apples. An efficient and consistent extraction method for apple fruits was used to compare the immunoreactivities of extracts of different varieties (McIntosh, Red Delicious, Granny Smith, and Golden Delicious) of freshly picked and store-purchased apples. We found that Golden Delicious apples had the greatest amount of the 18 kd allergen, which has been reported to be a potent IgE-binding apple allergen. Store-purchased apples contained higher concentrations of the 18 kd allergen than freshly picked apples. In our study only 37.5% of sera reacted to the 18 kd protein, whereas 75% of the sera reacted to a 31 kd allergen. Other immunoreactive bands in apple extracts included proteins of 50, 38, 16, 14, and 13 kd. The amino-terminal amino acid sequences of the two major allergens, 18 kd and 31 kd, were determined. These sequences shared approximately 50% identity with disease resistance proteins of various plants or Bet v 1 in birch tree pollens. The appearance of various allergens was also investigated in mature apples during storage. The amount of 18 kd allergen increased significantly when apples were stored at 4 degrees C. However, under controlled atmospheric conditions in which oxygen- and carbon dioxide-induced ripening were regulated, the amount of 18 kd allergen remained unaffected. Because ripening and maturation were not associated with increases in 18 kd allergen content, the observed changes might be induced by factors related to disease resistance.

  9. Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.

    PubMed

    Espinosa, Felipe; Torres-Vega, Miguel A; Marks, Gerald A; Joho, Rolf H

    2008-05-21

    The genes Kcnc1 and Kcnc3 encode the subunits for the fast-activating/fast-deactivating, voltage-gated potassium channels Kv3.1 and Kv3.3, which are expressed in several brain regions known to be involved in the regulation of the sleep-wake cycle. When these genes are genetically eliminated, Kv3.1/Kv3.3-deficient mice display severe sleep loss as a result of unstable slow-wave sleep. Within the thalamocortical circuitry, Kv3.1 and Kv3.3 subunits are highly expressed in the thalamic reticular nucleus (TRN), which is thought to act as a pacemaker at sleep onset and to be involved in slow oscillatory activity (spindle waves) during slow-wave sleep. We showed that in cortical electroencephalographic recordings of freely moving Kv3.1/Kv3.3-deficient mice, spectral power is reduced up to 70% at frequencies <15 Hz. In addition, the number of sleep spindles in vivo as well as rhythmic rebound firing of TRN neurons in vitro is diminished in mutant mice. Kv3.1/Kv3.3-deficient TRN neurons studied in vitro show approximately 60% increase in action potential duration and a reduction in high-frequency firing after depolarizing current injections and during rebound burst firing. The results support the hypothesis that altered electrophysiological properties of TRN neurons contribute to the reduced EEG power at slow frequencies in the thalamocortical network of Kv3-deficient mice.

  10. The close binary frequency of Wolf-Rayet stars as a function of metallicity in M31 and M33

    SciTech Connect

    Neugent, Kathryn F.; Massey, Philip E-mail: phil.massey@lowell.edu

    2014-07-01

    Massive star evolutionary models generally predict the correct ratio of WC-type and WN-type Wolf-Rayet stars at low metallicities, but underestimate the ratio at higher (solar and above) metallicities. One possible explanation for this failure is perhaps single-star models are not sufficient and Roche-lobe overflow in close binaries is necessary to produce the 'extra' WC stars at higher metallicities. However, this would require the frequency of close massive binaries to be metallicity dependent. Here we test this hypothesis by searching for close Wolf-Rayet binaries in the high metallicity environments of M31 and the center of M33 as well as in the lower metallicity environments of the middle and outer regions of M33. After identifying ∼100 Wolf-Rayet binaries based on radial velocity variations, we conclude that the close binary frequency of Wolf-Rayets is not metallicity dependent and thus other factors must be responsible for the overabundance of WC stars at high metallicities. However, our initial identifications and observations of these close binaries have already been put to good use as we are currently observing additional epochs for eventual orbit and mass determinations.

  11. Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors

    SciTech Connect

    Heiss, W.D.; Heindel, W.; Herholz, K.; Rudolf, J.; Bunke, J.; Jeske, J.; Friedmann, G. )

    1990-03-01

    Positron emission tomography (PET) of 2(18F)-fluoro-2-deoxy-D-glucose (FDG) and volume-selective phosphorus-31 magnetic resonance spectroscopy (31P-MRS) are methods used to assess the energy metabolism of the brain. Both methods were studied with respect to their contribution to differential diagnosis in 23 patients with various brain tumors. The various neuroectodermal tumors differed with respect to their metabolic rate for glucose (MRGL). Benign and malignant tumors could be better differentiated by using tumor metabolism relative to contralateral brain and by evaluating heterogeneities in tumors. Low-grade gliomas usually showed normal 31P-MR spectra; high-grade gliomas were characterized by reduced and often split phosphodiester peaks and alkaline pH. Meningiomas, which had variable MRGL, typically showed extremely low phosphocreatine levels, reduced phosphodiesters, and alkaline pH. We concluded that FDG-PET and 31P-MRS examine different aspects of tumor metabolism. Therefore, both can contribute independently and complementarily to the differential diagnosis of brain tumors.

  12. Free-to-roll tests of X-31 and F-18 subscale models with correlation to flight test results

    NASA Technical Reports Server (NTRS)

    Williams, David L., II; Nelson, Robert C.; Fisher, David F.

    1994-01-01

    This presentation will concentrate on a series of low-speed wind tunnel tests conducted on a 2.5 percent subscale F-18 model and a 2 percent subscale X-31 model. The model's control surfaces were unaugmented; and for the most part, were deflected at a constant angle throughout the tests. The tests consisted mostly of free-to-roll experiments conducted with the use of an air-bearing, surface pressure measurements, off-surface flow visualization, and force-balance tests. Where possible the results of the subscale tests have been compared to flight test data, or to other wind tunnel data taken at higher Reynolds numbers.

  13. Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans

    PubMed Central

    Solinger, Jachen A.; Spang, Anne

    2014-01-01

    The end of the life of a transport vesicle requires a complex series of tethering, docking, and fusion events. Tethering complexes play a crucial role in the recognition of membrane entities and bringing them into close opposition, thereby coordinating and controlling cellular trafficking events. Here we provide a comprehensive RNA interference analysis of the CORVET and HOPS tethering complexes in metazoans. Knockdown of CORVET components promoted RAB-7 recruitment to subapical membranes, whereas in HOPS knockdowns, RAB-5 was found also on membrane structures close to the cell center, indicating the RAB conversion might be impaired in the absence of these tethering complexes. Unlike in yeast, metazoans have two VPS33 homologues, which are Sec1/Munc18 (SM)-family proteins involved in the regulation of membrane fusion. We assume that in wild type, each tethering complex contains a specific SM protein but that they may be able to substitute for each other in case of absence of the other. Of importance, knockdown of both SM proteins allowed bypass of the endosome maturation block in sand-1 mutants. We propose a model in which the SM proteins in tethering complexes are required for coordinated flux of material through the endosomal system. PMID:25273556

  14. Site-specificity of ethanol-induced dephosphorylation of rat hepatocyte keratins 8 and 18: A 31P NMR study.

    PubMed

    Eckert, B S; Yeagle, P L

    1996-01-01

    Chronic feeding of ethanol to rats results in disorganization of the keratin intermediate filament network within hepatocytes. Previous studies from this laboratory have shown that intermediate filament organization in cultured cells is related to the phosphorylation state of the proteins. Therefore, we have examined the phosphorylation state of hepatocyte keratins from control and ethanol-fed rats. Feeding ethanol to rats results in dephosphorylation of one site on keratin 8 and one site on keratin 18 at all time points beginning with 6 weeks of ethanol treatment. Dephosphorylation was detected by phosphate analysis and by two-dimensional electrophoresis in which a change in isoelectric point of keratins from ethanol-fed rats was observed. These observations indicate that dephosphorylation of keratins in ethanol-fed animals may be an early step in alcoholic hepatitis which has occurred by 6 weeks of ethanol treatment. To further characterize keratin dephosphorylation in ethanol-fed rats, we used 31P NMR spectroscopy to classify the dephosphorylation site(s). Hepatocyte keratins were purified and solubilized in 9.5 M urea, 10 mM Tris-Cl, pH 8.1. 31P NMR spectra were obtained at 109 MHz, in 10 mm tubes at 30 degrees C. Samples of hepatocyte keratins were phosphorylated with A-kinase, protein kinase C, casein kinase II or Ca/CAM kinase and these samples were analyzed by 31P NMR spectroscopy. The resulting spectra were used as standards to compare the 31P chemical shifts of the resonances produced by these kinases with the phosphorus resonances of control and experimental samples. The 31P NMR spectrum of control hepatocyte keratins shows three resonances at 0.7, 4 and 5 ppm. In vitro phosphorylation by A-kinase produces a resonance at 4 ppm which is distinctly different from the resonance produced by each of the other kinases. In hepatocyte keratins from ethanol-fed animals, the resonance at 4 ppm was missing from the spectrum. These observations indicate that the

  15. Prenatal diagnosis of familial dysautonomia by analysis of linked CA-repeat polymorphisms on chromosome 9q31-q33

    SciTech Connect

    Eng, C.M.; Desnick, R.J.; Slaugenhaupt, S.A.; Gusella, J.F.

    1995-11-20

    Familial dysautonomia (FD) is an autosomal recessive sensory neuropathy that affects about 1 in 3,700 individuals of Ashkenazi Jewish ancestry. The underlying biochemical and genetic defects are unknown, thereby precluding prenatal diagnosis in at-risk families. Recently, the FD gene (DYS) was mapped with strong linkage disequilibrium to polymorphic markers in the chromosome 9 region q31-q33. In this report, the use of these markers for the prenatal diagnosis of FD by linkage analysis in families with a previously affected child was evaluated. Genomic DNA from appropriate family members was analyzed to construct haplotypes using informative CA repeat polymorphisms closely linked to and flanking the FD locus. The calculation of risk for the prenatal diagnoses was performed by linkage analysis. All seven FD families were informative for the closely linked polymorphic markers and fetal diagnoses were made in eight pregnancies. Six fetal diagnoses were predicted with >98% accuracy, while two with recombinations were predicted with at least 88% and 92% accuracy. Use of these closely linked markers permitted the reliable prenatal diagnosis of FD in families with a previously affected child. 14 refs., 3 figs.

  16. Three-region specific microdissection libraries for the long arm of human chromosome 2, regions q33-q35, q31-q32, and q23-q24

    SciTech Connect

    Yu, J.; Tong, S.; Whittier, A.

    1995-09-01

    Three region-specific libraries have been constructed from the long arm of human chromosome 2, including regions 2q33-35 (2Q2 library), 2q31-32 (2Q3) and 2q23-24 (2Q4). Chromosome microdissection and the MboI linker-adaptor microcloning techniques were used in constructing these libraries. The libraries comprised hundreds of thousands of microclones in each library. Approximately half of the microclones in the library contained unique or low-copy number sequence inserts. The insert sizes ranged between 50 and 800 bp, with a mean of 130-190 bp. Southern blot analysis of individual unique sequence microclones showed that 70-94% of the microclones were derived from the dissected region. 31 unique sequence microclones from the 2Q2 library, 31 from 2Q3, and 30 from 2Q4, were analyzed for insert sizes, the hybridizing genomic HindIII fragment sizes, and cross-hybridization to rodent species. These libraries and the short insert microclones derived from the libraries should be useful for high resolution physical mapping, sequence-ready reagents for large scale genomic sequencing, and positional cloning of disease-related genes assigned to these regions, e.g. the recessive familial amyotrophic lateral sclerosis assigned to 2q33-q35, and a type I diabetes susceptibility gene to 2q31-q33. 17 refs., 5 figs., 2 tabs.

  17. A high-resolution mid-Pleistocene temperature record from Arctic Lake El'gygytgyn: a 50 kyr super interglacial from MIS 33 to MIS 31?

    NASA Astrophysics Data System (ADS)

    de Wet, Gregory A.; Castañeda, Isla S.; DeConto, Robert M.; Brigham-Grette, Julie

    2016-02-01

    Previous periods of extreme warmth in Earth's history are of great interest in light of current and predicted anthropogenic warming. Numerous so called ;super interglacial; intervals, with summer temperatures significantly warmer than today, have been identified in the 3.6 million year (Ma) sediment record from Lake El'gygytgyn, northeast Russia. To date, however, a high-resolution paleotemperature reconstruction from any of these super interglacials is lacking. Here we present a paleotemperature reconstruction based on branched glycerol dialkyl glycerol tetraethers (brGDGTs) from Marine Isotope Stages (MIS) 35 to MIS 29, including super interglacial MIS 31. To investigate this period in detail, samples were analyzed with an unprecedented average sample resolution of 500 yrs from MIS 33 to MIS 30. Our results suggest the entire period currently defined as MIS 33-31 (∼1114-1062 kyr BP) was characterized by generally warm and highly variable conditions at the lake, at times out of phase with Northern Hemisphere summer insolation, and that cold ;glacial; conditions during MIS 32 lasted only a few thousand years. Close similarities are seen with coeval records from high southern latitudes, supporting the suggestion that the interval from MIS 33 to MIS 31 was an exceptionally long interglacial (Teitler et al., 2015). Based on brGDGT temperatures from Lake El'gygytgyn (this study and unpublished results), warming in the western Arctic during MIS 31 was matched only by MIS 11 during the Pleistocene.

  18. Filling of Spirit Lake, Washington, May 18, 1980 to July 31, 1982

    USGS Publications Warehouse

    Meyer, William; Carpenter, Philip J.

    1983-01-01

    The rockslide/debris avalanche from the north face of Mount St. Helens that precipitated the volcano 's eruption on May 18, 1980 , blocked outflow from Spirit Lake, Washington. There has been no surface outflow since that time. From May 21, 1980, when the first measurement of lake level was made, to August 1, 1982, Spirit Lake has increased its volume from 122,800 acre-ft to 264 ,000 acre-ft, an increase of 115%. Lake level has risen approximately 54 ft during this period. Hydrologic and geologic properties of the debris dam are unknown, but the materials obviously are easily erodible. Steep walled channels up to 60 ft deep have been eroded into the dam and are extending headward toward the lowest points on the crest. In addition, it appears that the lower areas on the crest of the dam are underlain by ash cloud deposits of low density. Indications are that the debris dam could fail by headward erosion, by overtopping with rapid downcutting, or by ' piping ' and rapid erosion. Each type of failure can produce rapid release of stored lake water with very high discharge rates. On the basis of observed filling rates of the lake over the last two yr and precipitation records at four long-term, low altitude National Weather Service stations, it is expected that normal precipitation will fill the lake to the dam crest in December 1985. This estimate is also based on the assumption that loss of water from the lake by seepage continues at the present rate until December 1985. With normal precipitation during the coming yr (August 1982 through July 1983 the lake will fill to a level 50 ft below the lowest existing point on the crest of the debris dam, which is at 3,532 ft altitude. If precipitation exceeds normal by 1.5 times during this coming year, the lake level will be 40 ft below the 3 ,532-ft crest of the debris dam by the end of July 1983. This same lake level can be reached by the end of March 1983 if precipitation from October through March is twice the winter mean

  19. Probing the crucial role of Leu31 and Thr33 of the Bacillus pumilus CBS alkaline protease in substrate recognition and enzymatic depilation of animal hide.

    PubMed

    Zaraî Jaouadi, Nadia; Jaouadi, Bassem; Ben Hlima, Hajer; Rekik, Hatem; Belhoul, Mouna; Hmidi, Maher; Ben Aicha, Houda Slimene; Hila, Chiraz Gorgi; Toumi, Abdessatar; Aghajari, Nushin; Bejar, Samir

    2014-01-01

    The sapB gene, encoding Bacillus pumilus CBS protease, and seven mutated genes (sapB-L31I, sapB-T33S, sapB-N99Y, sapB-L31I/T33S, sapB-L31I/N99Y, sapB-T33S/N99Y, and sapB-L31I/T33S/N99Y) were overexpressed in protease-deficient Bacillus subtilis DB430 and purified to homogeneity. SAPB-N99Y and rSAPB displayed the highest levels of keratinolytic activity, hydrolysis efficiency, and enzymatic depilation. Interestingly, and at the semi-industrial scale, rSAPB efficiently removed the hair of goat hides within a short time interval of 8 h, thus offering a promising opportunity for the attainment of a lime and sulphide-free depilation process. The efficacy of the process was supported by submitting depilated pelts and dyed crusts to scanning electron microscopic analysis, and the results showed well opened fibre bundles and no apparent damage to the collagen layer. The findings also revealed better physico-chemical properties and less effluent loads, which further confirmed the potential candidacy of the rSAPB enzyme for application in the leather industry to attain an ecofriendly process of animal hide depilation. More interestingly, the findings on the substrate specificity and kinetic properties of the enzyme using the synthetic peptide para-nitroanilide revealed strong preferences for an aliphatic amino-acid (valine) at position P1 for keratinases and an aromatic amino-acid (phenylalanine) at positions P1/P4 for subtilisins. Molecular modeling suggested the potential involvement of a Leu31 residue in a network of hydrophobic interactions, which could have shaped the S4 substrate binding site. The latter could be enlarged by mutating L31I, fitting more easily in position P4 than a phenylalanine residue. The molecular modeling of SAPB-T33S showed a potential S2 subside widening by a T33S mutation, thus suggesting its importance in substrate specificity.

  20. Probing the Crucial Role of Leu31 and Thr33 of the Bacillus pumilus CBS Alkaline Protease in Substrate Recognition and Enzymatic Depilation of Animal Hide

    PubMed Central

    Zaraî Jaouadi, Nadia; Jaouadi, Bassem; Ben Hlima, Hajer; Rekik, Hatem; Belhoul, Mouna; Hmidi, Maher; Aicha, Houda Slimene Ben; Hila, Chiraz Gorgi; Toumi, Abdessatar; Aghajari, Nushin; Bejar, Samir

    2014-01-01

    The sapB gene, encoding Bacillus pumilus CBS protease, and seven mutated genes (sapB-L31I, sapB-T33S, sapB-N99Y, sapB-L31I/T33S, sapB-L31I/N99Y, sapB-T33S/N99Y, and sapB-L31I/T33S/N99Y) were overexpressed in protease-deficient Bacillus subtilis DB430 and purified to homogeneity. SAPB-N99Y and rSAPB displayed the highest levels of keratinolytic activity, hydrolysis efficiency, and enzymatic depilation. Interestingly, and at the semi-industrial scale, rSAPB efficiently removed the hair of goat hides within a short time interval of 8 h, thus offering a promising opportunity for the attainment of a lime and sulphide-free depilation process. The efficacy of the process was supported by submitting depilated pelts and dyed crusts to scanning electron microscopic analysis, and the results showed well opened fibre bundles and no apparent damage to the collagen layer. The findings also revealed better physico-chemical properties and less effluent loads, which further confirmed the potential candidacy of the rSAPB enzyme for application in the leather industry to attain an ecofriendly process of animal hide depilation. More interestingly, the findings on the substrate specificity and kinetic properties of the enzyme using the synthetic peptide para-nitroanilide revealed strong preferences for an aliphatic amino-acid (valine) at position P1 for keratinases and an aromatic amino-acid (phenylalanine) at positions P1/P4 for subtilisins. Molecular modeling suggested the potential involvement of a Leu31 residue in a network of hydrophobic interactions, which could have shaped the S4 substrate binding site. The latter could be enlarged by mutating L31I, fitting more easily in position P4 than a phenylalanine residue. The molecular modeling of SAPB-T33S showed a potential S2 subside widening by a T33S mutation, thus suggesting its importance in substrate specificity. PMID:25264614

  1. The effects of annealing on the microstructure and mechanical properties of Fe28Ni18Mn33Al21

    DOE PAGES

    Meng, Fanling; Qiu, Jingwen; Baker, Ian; ...

    2015-08-20

    In this paper, As-cast Fe28Ni18Mn33Al21, which consists of aligned, 50 nm, (Ni, Al)-rich B2, and (Fe, Mn)-rich f.c.c. phases, was annealed at a variety of temperatures up to 1423 K and the microstructure and mechanical properties were examined. It was shown that the as-cast microstructure arises from a eutectoid transformation at ~1300 K. Annealing at temperatures ≤1073 K produces β-Mn-structured precipitates and hardness values up to 816 HV, while annealing at temperatures >1073 K leads to dramatic coarsening of the two-phase B2/f.c.c. microstructure (up to 5.5 µm after 50 h at 1273 K), but does not lead to β-Mn precipitation.more » Interestingly, annealing at temperatures >1073 K delays the onset of β-Mn precipitation during subsequent anneals at lower temperatures. Coarsening the B2/f.c.c. lamellar structure by annealing at higher temperatures softens it and leads to increases in ductility from fracture before yield to ~8 % elongation. Finally, the presence of β-Mn precipitates makes the very fine, brittle B2/f.c.c. microstructures even more brittle, but significant ductility (8.4 % elongation) is possible even with β-Mn precipitates present if the B2/f.c.c. matrix is coarse and, hence, more ductile.« less

  2. Corrosion-resistant amorphous metallic films of Mo/sub 49/Cr/sub 33/B/sub 18/ alloy

    SciTech Connect

    Ramesham, R.; DiStefano, S.; Fitzgerald, D.; Thakoor, A.P.; Khanna, S.K.

    1987-09-01

    Amorphous metallic films of Mo/sub 49/Cr/sub 33/B/sub 18/ have been deposited onto glass and quartz substrates by the magnetron sputter quenching technique. The amorphous nature of the as-deposited films was confirmed by their diffuse x-ray diffraction patterns. The crystallization temperature of the as-deposited films was 590/sup 0/C, according to the differential scanning calorimetry studies. Surface texture and cross-sectional features of the coatings were examined by scanning electron microscopy. Electron microprobe analysis was used to determine the chemical composition of the films. Chemical compositional uniformity of the as-deposited amorphous metallic films was verified by secondary ion mass spectrometry. As-deposited films exhibited microhardness of the order of 600-850 HV. Kinetics of corrosion of the alloy films in H/sub 2/SO/sub 4/ (1N) solution has been studied by potentiodynamic and galvanostatic techniques. As-deposited amorphous films exhibited corrosion current density three orders of magnitude less than the corrosion current density of 304 stainless steel in H/sub 2/SO/sub 4/ (1N) solution. A reaction mechanism at the corrosion potential is proposed.

  3. 75 FR 61989 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-8-31, DC-8-32, DC-8-33, DC-8-41...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... Corporation Model DC- 8-31, DC-8-32, DC-8-33, DC-8-41, DC-8-42, and DC-8-43 Airplanes; Model DC-8-50 Series Airplanes; Model DC-8F-54 and DC-8F-55 Airplanes; Model DC-8-60 Series Airplanes; Model DC-8-60F Series Airplanes; Model DC-8- 70 Series Airplanes; and Model DC-8-70F Series Airplanes AGENCY:......

  4. A 7q31.33q32.1 microdeletion including LRRC4 and GRM8 is associated with severe intellectual disability and characteristics of autism

    PubMed Central

    Sangu, Noriko; Shimojima, Keiko; Takahashi, Yuya; Ohashi, Tsukasa; Tohyama, Jun; Yamamoto, Toshiyuki

    2017-01-01

    A 4-year-old boy with severe intellectual disability (ID) and characteristics of autism was found to have a de novo 1.9-Mb microdeletion in 7q31.33q32.1, in which LRRC4, GRM8, and 11 other genes were included. GRM8 is associated with attention deficit hyperactivity disorder. LRRC4 is related to synaptic cell adhesion molecules, some of which are associated with autism. The deletion of LRRC4 may be responsible for the severe ID and characteristics of autism observed in the present patient. PMID:28224041

  5. Luminous and variable stars in M31 and M33. II. Luminous blue variables, candidate LBVs, Fe II emission line stars, and other supergiants

    SciTech Connect

    Humphreys, Roberta M.; Davidson, Kris; Weis, Kerstin; Bomans, D. J.; Burggraf, Birgitta E-mail: kweis@astro.rub.de

    2014-07-20

    An increasing number of non-terminal eruptions are being found in the numerous surveys for optical transients. Very little is known about these giant eruptions, their progenitors and their evolutionary state. A greatly improved census of the likely progenitor class, including the most luminous evolved stars, the luminous blue variables (LBVs), and the warm and cool hypergiants is now needed for a complete picture of the final pre-supernova stages of very massive stars. We have begun a survey of the evolved and unstable luminous star populations in several nearby resolved galaxies. In this second paper on M31 and M33, we review the spectral characteristics, spectral energy distributions, circumstellar ejecta, and evidence for mass loss for 82 luminous and variable stars. We show that many of these stars have warm circumstellar dust including several of the Fe II emission line stars, but conclude that the confirmed LBVs in M31 and M33 do not. The confirmed LBVs have relatively low wind speeds even in their hot, quiescent or visual minimum state compared to the B-type supergiants and Of/WN stars which they spectroscopically resemble. The nature of the Fe II emission line stars and their relation to the LBV state remains uncertain, but some have properties in common with the warm hypergiants and the sgB[e] stars. Several individual stars are discussed in detail. We identify three possible candidate LBVs and three additional post-red supergiant candidates. We suggest that M33-013406.63 (UIT301,B416) is not an LBV/S Dor variable, but is a very luminous late O-type supergiant and one of the most luminous stars or pair of stars in M33.

  6. P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane

    PubMed Central

    Hassan, Mohamed Kamel; Watari, Hidemichi; Mitamura, Takashi; Mohamed, Zainab; EL-khamisy, Sherif F.; Ohba, Yusuke; Sakuragi, Noriaki

    2015-01-01

    MicroRNAs (miRNAs) have been reported to regulate the development of chemoresistance in many tumors. Stathmin 1 (STMN1) is a microtubule-depolymerizing molecule, involved in chemo-response; however, the mechanism of its regulation is unknown. Herein, the immunohistochemical study indicated significant upregulation of the STMN1 in the ovarian cancer tissues defined as resistant tumors compared with those defined as responsive tumors. STMN1 level elevated in the chemoresistant ovarian cancer cells, KF-TX, compared with the parental, KF, ones. Targeting STMN1 by siRNA restored taxane-sensitivity of KF-TX cells. Screening miRNA profiles from KF/KF-TX cellular set followed by bioinformatics-based prediction, revealed that miR-31 could be a possible regulator of STMN1. Down-modulation of miR-31 was verified by quantitative RT-PCR in the cellular set used. Overexpression of miR-31 in KF-TX cells (KF-TX-miR-31) significantly restored chemo-response and reduced STMN1 expression as well. STMN1 reduction-associated cellular characteristics such as enhanced microtubule polymerization and stability, as indicated by acetylated tubulin quantification, confocal visualization, and G2 phase delay, were observed in KF-TX-miR-31 cells, indicating the functional reduction of STMN1. miR-31 suppressed the luciferase activity in reporter construct containing the STMN1 3′-untranslated region (3′-UTR), confirming that miR-31 directly targets STMN1. miR-31 has therapeutic potency when introduced into ovarian cancer, in combination with taxane. PMID:25897432

  7. P18/Stathmin1 is regulated by miR-31 in ovarian cancer in response to taxane.

    PubMed

    Hassan, Mohamed Kamel; Watari, Hidemichi; Mitamura, Takashi; Mohamed, Zainab; El-Khamisy, Sherif F; Ohba, Yusuke; Sakuragi, Noriaki

    2015-01-01

    MicroRNAs (miRNAs) have been reported to regulate the development of chemoresistance in many tumors. Stathmin 1 (STMN1) is a microtubule-depolymerizing molecule, involved in chemo-response; however, the mechanism of its regulation is unknown. Herein, the immunohistochemical study indicated significant upregulation of the STMN1 in the ovarian cancer tissues defined as resistant tumors compared with those defined as responsive tumors. STMN1 level elevated in the chemoresistant ovarian cancer cells, KF-TX, compared with the parental, KF, ones. Targeting STMN1 by siRNA restored taxane-sensitivity of KF-TX cells. Screening miRNA profiles from KF/KF-TX cellular set followed by bioinformatics-based prediction, revealed that miR-31 could be a possible regulator of STMN1. Down-modulation of miR-31 was verified by quantitative RT-PCR in the cellular set used. Overexpression of miR-31 in KF-TX cells (KF-TX-miR-31) significantly restored chemo-response and reduced STMN1 expression as well. STMN1 reduction-associated cellular characteristics such as enhanced microtubule polymerization and stability, as indicated by acetylated tubulin quantification, confocal visualization, and G2 phase delay, were observed in KF-TX-miR-31 cells, indicating the functional reduction of STMN1. miR-31 suppressed the luciferase activity in reporter construct containing the STMN1 3'-untranslated region (3'-UTR), confirming that miR-31 directly targets STMN1. miR-31 has therapeutic potency when introduced into ovarian cancer, in combination with taxane.

  8. Correlation between plasma, synovial fluid and articular cartilage Interleukin-18 with radiographic severity in 33 patients with osteoarthritis of the knee.

    PubMed

    Wang, Youhua; Xu, Dawei; Long, Long; Deng, Xiaolong; Tao, Ran; Huang, Guicheng

    2014-08-01

    Osteoarthritis (OA) is a complex disease characterized by cartilage degeneration, secondary synovial membrane inflammation and subchondral bone changes. In recent years, many studies have confirmed that interleukin-18 (IL-18) is involved in the inflammatory process of inflammatory joint diseases. In the present study, we investigated IL-18 levels in plasma, synovial fluid and articular cartilage of patients with primary knee OA (n = 33) to analyze their relationship with radiographic severity. Compared to healthy controls (n = 15), OA patients had higher plasma and synovial fluid IL-18 concentrations(45.8 ± 22.1 vs. 23.7 ± 13.6 pg/ml, P<0.001 and 75.2 ± 40.1 vs. 28.3 ± 11.6 pg/ml, P<0.001) as measured by enzyme-linked immunosorbent assay. Also,the percentage of immunofluorescent IL-18 positive cells in articular cartilage was significantly increased in OA compared to controls (46.5 ± 10.3 vs. 2.9 ± 1.7, P<0.001). Moreover, plasma, synovial fluid and articular cartilage IL-18 significantly positively correlated with radiographic severity, respectively (r = 0.663, P<0.001, r = 0.56, P = 0.001 and r = 0.884, P<0.001). Subsequent analysis revealed that plasma, synovial fluid and articular cartilage IL-18 levels positively correlated with each other (r = 0.632, P<0.001, r = 0.489, P = 0.004 and r = 0.620, P<0.001). These data suggested that plasma, synovial fluid and articular cartilage IL-18 levels were significantly increased in OA patients, and these elevated levels were positively correlated with radiographic severity. Accordingly, our study supports the role of IL-18 in the pathophysiology of OA.

  9. Luminous and Variable Stars in M31 and M33. III. The Yellow and Red Supergiants and Post-red Supergiant Evolution

    NASA Astrophysics Data System (ADS)

    Gordon, Michael S.; Humphreys, Roberta M.; Jones, Terry J.

    2016-07-01

    Recent supernova (SN) and transient surveys have revealed an increasing number of non-terminal stellar eruptions. Though the progenitor class of these eruptions includes the most luminous stars, little is known of the pre-SN mechanics of massive stars in their most evolved state, thus motivating a census of possible progenitors. From surveys of evolved and unstable luminous star populations in nearby galaxies, we select a sample of yellow and red supergiant (RSG) candidates in M31 and M33 for review of their spectral characteristics and spectral energy distributions (SEDs). Since the position of intermediate- and late-type supergiants on the color-magnitude diagram can be heavily contaminated by foreground dwarfs, we employ spectral classification and multi-band photometry from optical and near-infrared surveys to confirm membership. Based on spectroscopic evidence for mass loss and the presence of circumstellar (CS) dust in their SEDs, we find that 30%-40% of the yellow supergiants are likely in a post-RSG state. Comparison with evolutionary tracks shows that these mass-losing, post-RSGs have initial masses between 20 and 40 M ⊙. More than half of the observed RSGs in M31 and M33 are producing dusty CS ejecta. We also identify two new warm hypergiants in M31, J004621.05+421308.06 and J004051.59+403303.00, both of which are likely in a post-RSG state. Based on observations obtained with the Large Binocular Telescope (LBT), an international collaboration among institutions in the United States, Italy, and Germany. LBT Corporation partners are: The University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; The Ohio State University, and The Research Corporation, on behalf of The University of Notre Dame, University of Minnesota, and University of Virginia.

  10. VizieR Online Data Catalog: Properties of X-ray sources in M31/M33 (Hatzidimitriou+, 2006)

    NASA Astrophysics Data System (ADS)

    Hatzidimitriou, D.; Pietsch, W.; Misanovic, Z.; Reig, P.; Haberl, F.

    2006-05-01

    The optical observations used in this study were carried out during three observing runs, on September 6, 2003, on October 18-22, 2003 and on October 10-11, 2004, using the 1.3-m Ritchey-Cretien telescope at Skinakas Observatory, located on the island of Crete (Greece). (3 data files).

  11. Empirical infrared line lists for five SO2 isotopologues: 32/33/34/36S16O2 and 32S18O2

    NASA Astrophysics Data System (ADS)

    Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2015-05-01

    Using the latest published, empirically refined potential energy surface (PES) Ames-1 and purely ab initio CCSD(T)/aug-cc-pV(Q+d)Z dipole moment surface (DMS), we have computed infrared line lists for five symmetric isotopologues of sulfur dioxide: 32S16O2 (626), 33S16O2 (636), 34S16O2 (646), 36S16O2 (666), and 32S18O2 (828). The line lists are based on J = 0-80 rovibrational variational calculations with E‧ ⩽ 8000 cm-1. The 34S16O2 and 33S16O2 line lists are compared to the experiment-based models in the HIgh-resolution TRANsmission molecular absorption database (HITRAN2012,

  12. Sr 18Ru 1.9Bi 4.1O 33: crystallization of a Ru(V)/Bi(V) oxide from molten hydroxide

    NASA Astrophysics Data System (ADS)

    Martín-González, Marisol S.; Delattre, James L.; Stacy, Angelica M.

    2003-06-01

    Single crystals of a new complex oxide, Sr 18Ru 1.9Bi 4.1O 33, were precipitated from a mixture of molten alkali and alkaline earth metal hydroxides at 750°C. The structure was determined from a ruby-red crystal using single-crystal X-ray diffraction. Sr 18Ru 1.88Bi 4.12O 33 crystallizes in the space group C2 /c (monoclinic) and has unit-cell dimensions: a=10.2102(11) Å, b=17.882(2) Å, c=19.579(2) Å, and β=102.043(2)°. The structure (refined to R1=4.5%, w R2=9.2%) is an unusual ABO 3 defect perovskite, with {1}/{12}th of the oxygen positions vacant. All the A sites and half of the B sites are occupied by Sr 2+, while the remaining B sites are occupied by Bi 5+ or Ru 5+. The oxygen atom vacancies are located within the Bi coordination sphere exclusively. The bonding in the BO 3 sublattice is less covalent than that in the perovskite archetype from which it is derived due to the presence of 50% Sr 2+ on the B sites. Thus, the structure of Sr 18Ru 1.9Bi 4.1O 33 can also be viewed as being made up of isolated bismuthate anions (BiO 55-, BiO 5.56- and BiO 67-) and ruthenate anions (RuO 67-) separated by strontium cations.

  13. Effects of Microalloying on the Microstructures and Mechanical Properties of Directionally Solidified Ni-33(at.%)Al-31Cr-3Mo Eutectic Alloys Investigated

    NASA Technical Reports Server (NTRS)

    Whittenberger, J. Daniel; Raj, Sai V.; Locci, Ivan E.; Salem, Jonathan A.

    2002-01-01

    Despite nickel aluminide (NiAl) alloys' attractive combination of oxidation and thermophysical properties, their development as replacements for superalloy airfoils in gas turbine engines has been largely limited by difficulties in developing alloys with an optimum combination of elevated-temperature creep resistance and room-temperature fracture toughness. Alternatively, research has focused on developing directionally solidified NiAl-based in situ eutectic composites composed of NiAl and (Cr,Mo) phases in order to obtain a desirable combination of properties a systematic investigation was undertaken at the NASA Glenn Research Center to examine the effects of small additions of 11 alloying elements (Co, Cu, Fe, Hf, Mn, Nb, Re, Si, Ta, Ti, and Zr) in amounts varying from 0.25 to 1.0 at.% on the elevated-temperature strength and room-temperature fracture toughness of directionally solidified Ni-33Al-31Cr-3Mo eutectic alloy. The alloys were grown at 12.7 mm/hr, where the unalloyed eutectic base alloy exhibited a planar eutectic microstructure. The different microstructures that formed because of these fifth-element additions are included in the table. The additions of these elements even in small amounts resulted in the formation of cellular microstructures, and in some cases, dendrites and third phases were observed. Most of these elemental additions did not improve either the elevated-temperature strength or the room-temperature fracture toughness over that of the base alloy. However, small improvements in the compression strength were observed between 1200 and 1400 K when 0.5 at.% Hf and 0.25 at.% Ti were added to the base alloy. The results of this study suggest that the microalloying of Ni-33Al-31Cr-3Mo will not significantly improve either its elevatedtemperature strength or its room-temperature fracture toughness. Thus, any improvements in these properties must be acquired by changing the processing conditions.

  14. Effect of Ti content on the microstructure and mechanical behavior of (Fe36Ni18Mn33Al13)100–xTix high entropy alloys

    DOE PAGES

    Wang, Zhangwei; Wu, Margaret; Cai, Zhonghou; ...

    2016-06-13

    The microstructure and mechanical properties studies of a series of two-phase f.c.c./B2 (ordered b.c.c.) lamellar-structured, high entropy alloys (HEA) Fe36Ni18Mn33Al13Tix with x up to 6 at. % Ti have been investigated. X-ray microanalysis in a TEM showed that the Ti resided mostly in the B2 phase. The lamellar spacing decreased significantly with increasing Ti content from 1.56 μm for the undoped alloy to 155 nm with an addition of 4 at. % Ti, leading to a sharp increase in room-temperature yield strength,σy, from 270 MPa to 953 MPa, but with a concomitant decrease in ductility from 22% elongation to 2.3%.more » Annealing at 1173 K for 20 h greatly increased the lamellar spacing of Fe36Ni18Mn33Al13Ti4 to 577 nm, producing a corresponding decrease in σy to 511 MPa. The yield strengths of all the doped alloys decreased significantly when tensile tested at 973 K with a concomitant increase in ductility due to softening of the B2 phase. The fracture mode changed from cleavage at room temperature to a ductile dimple-type rupture at 973 K. Lastly, the results are discussed in terms of the Hall-Petch-type relationship.« less

  15. Human papillomavirus genotype spectrum in Czech women: correlation of HPV DNA presence with antibodies against HPV-16, 18, and 33 virus-like particles.

    PubMed

    Tachezy, R; Hamsíková, E; Hájek, T; Mikysková, I; Smahel, M; Van Ranst, M; Kanka, J; Havránková, A; Rob, L; Guttner, V; Slavík, V; Anton, M; Kratochvíl, B; Kotrsová, L; Vonka, V

    1999-08-01

    Because the biological spectrum of human papillomavirus (HPV) genotypes present in cervical cancer lesions varies according to the geographical region studied, and because little genotype information is available for Central and Eastern European countries, we studied the endemic HPV-genotype spectrum in cervical samples collected from women visiting gynaecological departments of selected hospitals in the Czech Republic. In a series of 389 samples, 171 (44.0%) were positive for HPV DNA using a consensus-primer polymerase chain reaction (PCR). Genotyping of the HPV PCR products was done using dot-blot hybridisation with type-specific oligonucleotide probes and thermocycle DNA sequencing. Twenty-two different HPV types were detected, HPV-16 being the most prevalent type irrespective of severity of the lesions (55.0%). Multiple HPV types were found in 16.4% of our HPV-DNA-positive samples. The prevalence of HPV infection was 23.0% in women with normal findings and 59.4% in patients with cervical neoplasia, and increased significantly with the severity of the disease: 52.9% in low-grade lesions, 58.0% in high-grade lesions, and 73.5% in cervical carcinomas (P for trend < .00001). In the sera of 191 subjects, 89 with normal findings and 102 with different forms of cervical neoplasia, the prevalence of HPV-specific IgG antibodies was tested by an enzyme-linked immunosorbent assay (ELISA) using virus-like particles (VLPs) of HPV-16, -18, and -33. Antibodies were significantly more prevalent in HPV-DNA-positive than in HPV-DNA-negative women and there was no association with age. In agreement with the results of HPV genotyping, antibodies reactive with HPV-16 VLPs were the most frequent and, moreover, their prevalence increased with the cervical lesion severity. About half of the subjects with smears in which either HPV-16 or HPV-33 DNA had been detected possessed antibodies reactive with homotypic VLPs. With HPV-18-DNA-positive subjects, however, fewer than 25% displayed

  16. Comparison of the immunogenicity of the human papillomavirus (HPV)-16/18 vaccine and the HPV-6/11/16/18 vaccine for oncogenic non-vaccine types HPV-31 and HPV-45 in healthy women aged 18-45 years.

    PubMed

    Einstein, Mark H; Baron, Mira; Levin, Myron J; Chatterjee, Archana; Fox, Bradley; Scholar, Sofia; Rosen, Jeffrey; Chakhtoura, Nahida; Lebacq, Marie; van der Most, Robbert; Moris, Philippe; Giannini, Sandra L; Schuind, Anne; Datta, Sanjoy K; Descamps, Dominique

    2011-12-01

    Protection against oncogenic non-vaccine types (cross-protection) offered by human papillomavirus (HPV) vaccines may provide a significant medical benefit. Available clinical efficacy data suggest the two licensed vaccines (HPV-16/18 vaccine, GlaxoSmithKline Biologicals (GSK), and HPV-6/11/16/18 vaccine, Merck & Co., Inc.) differ in terms of protection against oncogenic non-vaccine HPV types -31/45. The immune responses induced by the two vaccines against these two non-vaccine HPV types (cross-reactivity) was compared in an observer-blind study up to Month 24 (18 mo post-vaccination), in women HPV DNA-negative and seronegative prior to vaccination for the HPV type analyzed (HPV-010 [NCT00423046]). Geometric mean antibody titers (GMTs) measured by pseudovirion-based neutralization assay (PBNA) and enzyme-linked immunosorbent assay (ELISA) were similar between vaccines for HPV-31/45. Seropositivity rates for HPV-31 were also similar between vaccines; however, there was a trend for higher seropositivity with the HPV-16/18 vaccine (13.0-16.7%) versus the HPV-6/11/16/18 vaccine (0.0-5.0%) for HPV-45 with PBNA, but not ELISA. HPV-31/45 cross-reactive memory B-cell responses were comparable between vaccines. Circulating antigen-specific CD4+ T-cell frequencies were higher for the HPV-16/18 vaccine than the HPV-6/11/16/18 vaccine (HPV-31 [geometric mean ratio [GMR] =2.0; p=0.0002] and HPV-45 [GMR=2.6; p=0.0092]), as were the proportion of T-cell responders (HPV-31, p=0.0009; HPV-45, p=0.0793). In conclusion, immune response to oncogenic non-vaccine HPV types -31/45 was generally similar for both vaccines with the exception of T-cell response which was higher with the HPV-16/18 vaccine. Considering the differences in cross-protective efficacy between the two vaccines, the results might provide insights into the underlying mechanism(s) of protection.

  17. Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method.

    PubMed

    Puente, Nagore; Mendizabal-Zubiaga, Juan; Elezgarai, Izaskun; Reguero, Leire; Buceta, Ianire; Grandes, Pedro

    2010-10-01

    A proper motor activity relies on a correct cerebellar function. The Kv3.1 and Kv3.3 voltage-gated potassium channels are key proteins involved in cerebellar function and dysfunction, as the lack of these causes severe motor deficits. Both channel subunits are coexpressed in granule cells and are rapidly activated at relatively positive potentials to support the generation of fast action potentials. However, the contribution of each subunit to the molecular architecture of the parallel fibers, the granule cell axons, is so far unknown. The goal of this study was to elucidate the relative distribution of Kv3.1b and Kv3.3 in specific compartments of the rat parallel fibers by using a pre-embedding immunocytochemical method for electron microscopy. Numerous Kv3.1b and Kv3.3 silver-intensified gold particles were associated with membranes of parallel fiber synaptic terminals and their intervaricose segments. Kv3.1b was found in about 85% of parallel fiber synaptic terminals and in about 47% of their intervaricose portions. However, only 28% of intervaricosities and 23% of parallel fiber presynaptic boutons were Kv3.3 immunopositive. The analysis also revealed that 54% of Purkinje cell dendritic spines localized Kv3.3. Although both potassium channel subunits share localization in the same presynaptic parallel fiber compartments, the present results with the method used indicate that there are a higher percentage of parallel fibers labeled for Kv3.1b than for Kv3.3, and that the labeling intensity for each subunit is higher in specific subcompartments analyzed than in others.

  18. Duplex Real-time PCR assay and SYBR green I melting curve analysis for molecular identification of HPV genotypes 16, 18, 31, 35, 51 and 66.

    PubMed

    Tsakogiannis, D; Papacharalampous, M; Toska, E; Kyriakopoulou, Z; Dimitriou, T G; Ruether, I G A; Komiotis, D; Markoulatos, P

    2015-02-01

    Long-term infection with high-risk HPV genotypes is the leading cause of cervical cancer. In the present study a Duplex Real-time PCR assay was developed in order to identify HPV types 16, 18, 31, 35, 51 and 66 in three reactions, through SYBR green I melting curve analysis. The method utilizes type-specific primer sets that allowed the amplification of highly conserved regions of L1 gene. Reconstitution experiments were conducted by using HPV DNA plasmids in order to determine the sensitivity of the assay. The newly designed assay has a limit of detection of 10 copies per reaction. The most prevalent HPV genotype in single and in multiple HPV infections was HPV16 followed by HPV18, HPV51, HPV31, HPV35 and HPV66. The proposed method is a simple, specific, sensitive and cost-effective assay that can be easily incorporated in small and medium size laboratories for the rapid identification of the most clinically important HPV genotypes.

  19. Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice.

    PubMed

    Alonso-Espinaco, V; Elezgarai, I; Díez-García, J; Puente, N; Knöpfel, T; Grandes, P

    2008-09-09

    Deep cerebellar dentate nuclei are in a key position to control motor planning as a result of an integration of cerebropontine inputs and hemispheric Purkinje neurons signals, and their influence through synaptic outputs onto extracerebellar hubs. GABAergic dentate neurons exhibit broader action potentials and slower afterhyperpolarization than non-GABAergic (presumably glutamatergic) neurons. Specific potassium channels may be involved in these distinct firing profiles, particularly, Kv3.1 and Kv3.3 subunits which rapidly activate at relatively positive potentials to support the generation of fast action potentials. To investigate the subcellular localization of Kv3.1b and Kv3.3 in GAD- and GAD+ dentate neurons of glutamic acid decarboxylase 67-green fluorescent protein (GAD67-GFP) knock-in mice a preembedding immunocytochemical method for electron microscopy was used. Kv3.1b and Kv3.3 were in membranes of cell somata, dendrites, axons and synaptic terminals of both GAD- and GAD+ dentate neurons. The vast majority of GAD- somatodendritic membrane segments domains labeled for Kv3.1b and Kv3.3 (96.1% and 84.7%, respectively) whereas 56.2% and 69.8% of GAD- axonal membrane segments were immunopositive for these subunits. Furthermore, density of Kv3.1b immunoparticles was much higher in GAD- somatodendritic than axonal domains. As to GAD+ neurons, only 70.6% and 50% of somatodendritic membrane segments, and 53.3% and 59.5% of axonal membranes exhibited Kv3.1b and Kv3.3 labeling, respectively. In contrast to GAD- cells, GAD+ cells exhibited a higher density labeling for both Kv3 subunits at their axonal than at their somatodendritic membranes. Taken together, Kv3.1b and Kv3.3 potassium subunits are expressed in both GAD- and GAD+ cells, albeit at different densities and distribution. They likely contribute to the distinct biophysical properties of both GAD- and GAD+ neurons in the dentate nucleus.

  20. Cellular immune responses to HPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles

    SciTech Connect

    Pinto, Ligia A.; Harro, Clayton D.; Kemp, Troy J.; Lowy, Douglas R.; Schiller, John T.; Berzofsky, Jay A.; Hildesheim, Allan

    2006-09-30

    Human papillomavirus-like particles (HPV VLP) are candidate vaccines that have shown to be efficacious in reducing infection and inducing robust antiviral immunity. Neutralizing antibodies generated by vaccination are largely type-specific, but little is known about the type-specificity of cellular immune responses to VLP vaccination. To determine whether vaccination with HPV-16 L1VLP induces cellular immunity to heterologous HPV types (HPV-18, HPV-31, and HPV-53), we examined proliferative and cytokine responses in vaccine (n = 11) and placebo (n = 5) recipients. Increased proliferative and cytokine responses to heterologous types were observed postvaccination in some individuals. The proportion of women responding to heterologous types postvaccination (36%-55%) was lower than that observed in response to HPV-16 (73%). Response to HPV-16 VLP predicted response to other types. The strongest correlations in response were observed between HPV-16 and HPV-31, consistent with their phylogenetic relatedness. In summary, PBMC from HPV-16 VLP vaccine recipients can respond to L1VLP from heterologous HPV types, suggesting the presence of conserved T cell epitopes.

  1. 31 CFR 359.33 - What happens if I purchase definitive Series I savings bonds in excess of the maximum amount?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Series I savings bonds in excess of the maximum amount? 359.33 Section 359.33 Money and Finance: Treasury... PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.33 What happens if I purchase definitive Series I savings bonds in excess of the maximum amount? If...

  2. 31 CFR 359.33 - What happens if I purchase definitive Series I savings bonds in excess of the maximum amount?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Series I savings bonds in excess of the maximum amount? 359.33 Section 359.33 Money and Finance: Treasury... PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES I Definitive Series I Savings Bonds § 359.33 What happens if I purchase definitive Series I savings bonds in excess of the maximum amount? If...

  3. The Stress Corrosion Resistance and the Cryogenic Temperature Mechanical Behavior of 18-3 Mn (Nitronic 33) Stainless Steel Parent and Welded Material

    NASA Technical Reports Server (NTRS)

    Montano, J. W.

    1976-01-01

    The ambient and cryogenic temperature mechanical properties and the ambient temperature stress corrosion results of 18-3 Mn (Nitronic 33)stainless steel, longitudinal and transverse, as received and as welded (TIG) material specimens manufactured from 0.063 inch thick sheet material, were described. The tensile test results indicate an increase in ultimate tensile and yield strengths with decreasing temperature. The elongation remained fairly constant to -200 F, but below that temperature the elongation decreased to less than 6.0% at liquid hydrogen temperature. The notched tensile strength (NTS) for the parent metal increased with decreasing temperature to liquid nitrogen temperature. Below -320 F the NTS decreased rapidly. The notched/unnotched (N/U) tensile ratio of the parent material specimens remained above 0.9 from ambient to -200 F, and decreased to approximately 0.65 and 0.62, respectively, for the longitudinal and transverse directions at liquid hydrogen temperature. After 180 days of testing, only those specimens exposed to the salt spray indicated pitting and some degradation of mechanical properties.

  4. The overexpression of the SAPB of Bacillus pumilus CBS and mutated sapB-L31I/T33S/N99Y alkaline proteases in Bacillus subtilis DB430: new attractive properties for the mutant enzyme.

    PubMed

    Jaouadi, Nadia Zaraî; Jaouadi, Bassem; Aghajari, Nushin; Bejar, Samir

    2012-02-01

    The sapB gene encoding for Bacillus pumilus CBS protease (SAPB) and the triple mutated sapB-L31I/T33S/N99Y gene were cloned and overexpressed in the protease-deficient Bacillus subtilis DB430 using an Escherichia coli-Bacillus shuttle vector pBSMuL2. The 34,625.13 and 34,675.11-Da enzymes were purified from the culture supernatant of B. subtilis expressing the wild-type and mutated genes, respectively. The purified proteases showed the same N-terminal sequences and biochemical properties of those expressed in E. coli. Further investigations demonstrated that, compared to wild-type and other proteases, SAPB-L31I/T33S/N99Y had the highest catalytic efficiency and the best degree of hydrolysis. The mutant enzyme was also noted to exhibit a number of newly explored properties that are highly valued in the marketplace, namely considerable stability to detergents, higher resistance towards organic solvents, and potent dehairing ability. Overall, the findings indicated that SAPB-L31I/T33S/N99Y is a promising candidate for future use in a wide range of industrial and commercial applications.

  5. 18. The west end of the dining room contains four ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. The west end of the dining room contains four windows that overlook Central Avenue. As other millwork in the restaurant, these windows were originally finished with stain and varnish. Transoms retain their original operators. Credit GADA/MRM. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  6. 1986 Nuclear Science Symposium, 33rd, and 1986 Symposium on Nuclear Power Systems, 18th, Washington, DC, Oct. 29-31, 1986, Proceedings

    NASA Technical Reports Server (NTRS)

    Stubblefield, F. W. (Editor)

    1987-01-01

    Papers are presented on space, low-energy physics, and general nuclear science instrumentations. Topics discussed include data acquisition systems and circuits, nuclear medicine imaging and tomography, and nuclear radiation detectors. Consideration is given to high-energy physics instrumentation, reactor systems and safeguards, health physics instrumentation, and nuclear power systems.

  7. Aerosol absorption coefficient and Equivalent Black Carbon by parallel operation of AE31 and AE33 aethalometers at the Zeppelin station, Ny Ålesund, Svalbard

    NASA Astrophysics Data System (ADS)

    Eleftheriadis, Konstantinos; Kalogridis, Athina-Cerise; Vratolis, Sterios; Fiebig, Markus

    2016-04-01

    Light absorbing carbon in atmospheric aerosol plays a critical role in radiative forcing and climate change. Despite the long term measurements across the Arctic, comparing data obtained by a variety of methods across stations requires caution. A method for extracting the aerosol absorption coefficient from data obtained over the decades by filter based instrument is still under development. An IASOA Aerosol working group has been initiated to address this and other cross-site aerosol comparison opportunities. Continuous ambient measurements of EBC/light attenuation by means of a Magee Sci. AE-31 aethalometer operating at the Zeppelinfjellet station (474 m asl; 78°54'N, 11°53'E), Ny Ålesund, Svalbard, have been available since 2001 (Eleftheriadis et al, 2009), while a new aethalometer model (AE33, Drinovec et al, 2014) has been installed to operate in parallel from the same inlet since June 2015. Measurements are recorded by a Labview routine collecting all available parameters reported by the two instrument via RS232 protocol. Data are reported at 1 and 10 minute intervals as averages for EBC (μg m-3) and aerosol absorption coefficients (Mm-1) by means of routine designed to report Near Real Time NRT data at the EBAS WDCA database (ebas.nilu.no) Results for the first 6 month period are reported here in an attempt to evaluate comparative performance of the two instruments in terms of their response with respect to the variable aerosol load of light absorbing carbon during the warm and cold seasons found in the high arctic. The application of available conversion schemes for obtaining the absorption coefficient by the two instruments is found to demonstrate a marked difference in their output. During clean periods of low aerosol load (EBC < 30 ng m-3), the two instruments display a better agreement with regression slope for the 880 nm signal between the two at ~ 0.9 compared to a slope at ~ 0.6 during the period of higher absorbing carbon loads (400< EBC<30 ng m

  8. Synthesis and biological evaluation of (E)-19-iodo-3,3-dimethyl-18-nonadecenoic acid, a new dimethyl-branched long-chain fatty acid to evaluate regional myocardial fatty acid uptake

    SciTech Connect

    Goodman, M.M.; Ambrose, K.R.; Neff, K.H.; Knapp, F.F. Jr.

    1986-01-01

    The synthetic method for the preparation of (E)-19-iodo-3,3-dimethyl-18-nonadecenoic acid (DMIVN) involved introduction of substituents into the 2- and 5-positions of a thiophene ring followed by sulfur extrusion of a 2,5-dialkyl thiophene derivative to provide a key 3,3-dimethyl-branched fatty acid intermediate, 17-iodo-3,3-dimethylheptadecanoic acid. Myocardial subcellular distribution studies of the /sup 125/I-labeled DMIVN in fasted rats showed a higher association of radioactivity with the microsomes when compared to the results obtained with the 19-carbon straight chain analogue. With the nonfasted rats the distribution profiles of the two analogues showed differences that seemed to correlate with the differences in myocardial retention that fasting and feeding can induce. 5 refs., 3 figs., 2 tabs.

  9. 33 CFR 151.31 - Where to find requirements applying to oceangoing ships carrying Category A, B, C, and D NLS.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER Implementation of... Pollution from Ships Noxious Liquid Substance Pollution § 151.31 Where to find requirements applying...

  10. 33 CFR 151.31 - Where to find requirements applying to oceangoing ships carrying Category A, B, C, and D NLS.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER Implementation of... Pollution from Ships Noxious Liquid Substance Pollution § 151.31 Where to find requirements applying...

  11. 33 CFR 151.31 - Where to find requirements applying to oceangoing ships carrying Category A, B, C, and D NLS.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER Implementation of... Pollution from Ships Noxious Liquid Substance Pollution § 151.31 Where to find requirements applying...

  12. 33 CFR 151.31 - Where to find requirements applying to oceangoing ships carrying Category A, B, C, and D NLS.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER Implementation of... Pollution from Ships Noxious Liquid Substance Pollution § 151.31 Where to find requirements applying...

  13. 33 CFR 151.31 - Where to find requirements applying to oceangoing ships carrying Category A, B, C, and D NLS.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER Implementation of... Pollution from Ships Noxious Liquid Substance Pollution § 151.31 Where to find requirements applying...

  14. Capability of SART3(109-118) peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles.

    PubMed

    Mohamed, Elnisr Rashed; Naito, Masayasu; Terasaki, Yasunobu; Niu, Yamei; Gohara, Shojiro; Komatsu, Nobukazu; Shichijo, Shigeki; Itoh, Kyogo; Noguchi, Masanori

    2009-02-01

    We previously reported the SART3 gene to be a tumor-rejection antigen gene encoding a peptide at positions 109-118 (SART3(109-118)) with the ability to induce HLA-A24-restricted cytotoxic T lymphocytes. In this study, we investigated both humoral and cellular responses to this peptide in cancer patients with alleles other than HLA-A24 to explore the possibility of using this peptide as a cancer vaccine for these patients. IgG reactive to SART3(109-118) peptide was identified in sera of the vast majority of non-cancer subjects (n=50) and all cancer patients (n=50) tested without apparent HLA-A association. Levels of anti-SART3(109-118) peptide antibody in cancer patients were significantly higher than those of non-cancer subjects, but no difference was found between HLA-A24+A2- and HLA-A24-A2+ cancer patients. This peptide induced cancer cell-reactive cytotoxic T lymphocytes from peripheral blood mononuclear cells of both healthy donors and prostate cancer patients with HLA-A11, HLA-A31 and HLA-A33 alleles, but not with HLA-A2. These results suggest that this peptide can be applicable as a cancer vaccine not only for HLA-A24+, but also for HLA-A11+, HLA-A31+ and HLA-A33+ prostate cancer patients.

  15. Coexpression of NUP98/TOP1 and TOP1/NUP98 in de novo Acute Myeloid Leukemia with t(11;20)(p15;q12) and t(2;5)(q33;q31).

    PubMed

    Yamamoto, Katsuya; Minami, Yosuke; Yakushijin, Kimikazu; Mizutani, Yu; Inui, Yumiko; Kawamoto, Shinichiro; Matsui, Keiji; Nakamachi, Yuji; Kawano, Seiji; Matsuoka, Hiroshi; Minami, Hironobu

    2016-01-01

    The t(11;20)(p15;q11∼12) translocation is a very rare but recurrent cytogenetic aberration that occurs in myelodysplastic syndrome/acute myeloid leukemia (MDS/AML). This translocation was shown to form a fusion gene between NUP98 at 11p15 and TOP1 at 20q12. Here, we describe a new case of de novo AML M2 with t(11;20) which was associated with another balanced translocation. An 81-year-old man was admitted to undergo salvage therapy for relapsed AML. G-banding and spectral karyotyping showed 46,XY,t(2;5)(q33;q31),t(11;20)(p15;q12)[20]. Expression of the NUP98/TOP1 fusion transcript was confirmed: NUP98 exon 13 was in-frame fused with TOP1 exon 8. The reciprocal TOP1/NUP98 fusion transcript was also detected: TOP1 exon 7 was fused with NUP98 exon 14. After achieving hematological complete remission, the karyotype converted to 46,XY,t(2;5)(q33;q31)[19]/46,sl,t(11;20)(p15;q12)[1]. FISH analysis demonstrated that the 5q31 breakpoint of t(2;5) was centromeric to EGR1. In all 10 cases described in the literature, the NUP98 exon 13/TOP1 exon 8 fusion transcript was expressed, indicating that it may be responsible for the pathogenesis of MDS/AML with t(11;20). On the other hand, the TOP1/NUP98 transcript was coexpressed in 4 cases of de novo AML, but not in 3 cases of therapy-related MDS. Thus, this reciprocal fusion may be associated with progression to AML.

  16. Nd3Ge1.18In0.82 and Sm3Ge1.33In0.67 - New ternary indides with La3GeIn type structure

    NASA Astrophysics Data System (ADS)

    Kravets, Oksana; Nychyporuk, Galyna; Muts, Ihor; Hlukhyy, Viktor; Pöttgen, Rainer; Zaremba, Vasyl'

    2014-06-01

    New indides, Nd3Ge1.18In0.82 and Sm3Ge1.33In0.67, were synthesized from the elements by arc-melting and subsequent annealing at 870 K. Single crystals were grown through special annealing procedures in sealed tantalum tubes in a resistance furnace. Both compounds were investigated on the basis of X-ray powder and single crystal data: La3GeIn type structure, Pearson code tI80, space group I4/mcm; a = 1200.1(1), c = 1562.8(1) pm, wR2 = 0.0781, 716 F2 values, 34 variables for Nd3Ge1.18In0.82 and a = 1184.7(2), c = 1537.0(3) pm, wR2 = 0.0305, 911 F2 values, 34 variables for Sm3Ge1.33In0.67. The crystal chemistry in Nd3Ge1.18In0.82 is discussed from a geometrical point of view and in terms of LMTO band structure calculations.

  17. Influence of Incremental Work Tasks on Thermoregulation in Air and during Immersion in 18, 26 and 33C Water: Special Reference to Moderately Fat Subjects.

    DTIC Science & Technology

    1980-12-01

    investigation has studied thermoregulation In a group of mod- erately fat (18-22% body fat ) college-age men during water immersion, and the...interrelationships between temperature (cold stress), work intensity (metabolic stress), and body composition (% body fat ). The metabolic, thermal, and car...close to Tw during sutmaximal exercise (-0.6C at 26.5C in 26C water; -0.7C at 19.7C in 18C water). In the present data, body fat provided protection

  18. Propargyl 4-[18F]fluorobenzoate: A Putatively More Stable Prosthetic group for the Fluorine-18 Labeling of Biomolecules via Click Chemistry

    PubMed Central

    Vaidyanathan, Ganesan; White, Benjamin J.; Zalutsky, Michael R.

    2010-01-01

    Faster and more efficient approaches for radiolabeling biomolecules with short-lived 18F are in dire need. Herein we report a new 18F-labeled prosthetic group containing an acetylene function that permits the labeling of biomolecules via click chemistry. This template, propargyl 4-[18F]fluorobenzoate ([18F]PFB) was synthesized from a quaternary salt precursor in decay-corrected radiochemical yields of 58 ± 31%. Several model compounds containing an azide moiety—benzyl azide, two lysine derivatives and a transglutaminase-reactive peptide—were labeled using [18F]PFB via a click reaction in decay-corrected radiochemical yields of 88 ± 4%, 79 ± 33%, 75 ± 5%, and 37 ± 31%, respectively. Our results suggest that the novel agent [18F]PFB is a potentially useful template for the 18F-labeling of biomolecules via click chemistry. PMID:20414475

  19. Influence of Incremental Work Tasks on Thermoregulation in Air and during Immersion in 18, 26 and 33 C Water: Special Reference to Moderately Fat Subjects.

    DTIC Science & Technology

    1980-12-01

    noeeeeary md identify by block number) LThe prescnt investigation has studied therregulation in a group of moder- ately fat (in-22% body fat ) college... body fat ). The metabolic, thermal, and cardio- vascular adjustments were determined at rest and during graded submaximal exer- cise in air and...0. 6Cat26.5C in 26C water; -O.7C at 19.7Cin 18Cwater). In the present. data, body fat provided protection to fat subjects exercising in cool .(26 C

  20. A rare mosaic interstitial deletion of 7q, 46,XX/46,XX,del(7)(q22.1q31.33), results in a mild clinical phenotype

    SciTech Connect

    Shapira, S.K.; Kochanek, S.; Shaffer, L.G.

    1994-09-01

    Constitutional mosaic structural rearrangements, including deletions, are extremely rare in the population. We present a case of mosaicism for a deletion of chromosome 7q. The patient`s phenotype is much milder than that of non-mosaic patients with a similar deletion of 7q. A 6 and 9/12-year-old Caucasian girl was evaluated because of attention deficit disorder and speech delay. She was born at 38 weeks gestation to her 37 year old G2P2 mother. Her birth weight was 2.2 kg (3rd centile), length was 47 cm (10th-25th centile), and OFC was 30.5 cm (<10th centile). Her motor development was normal. Her speech development was profoundly delayed with her first words spoken at 3 years, and 2-3 word sentences spoken at 5-6 years. At 6 and 9/12 years, she manifested mild mental retardation and profound speech delay, but only mildly dysmorphic features (protuberant ears with under-developed antihelices, flattened forehead, moderate micro-retrognathia). Height, weight, and OFC were at the 10th centile. Chromosomal analysis showed the presence of two cell lines, with 66% of the lymphocytes having a 46,XX pattern and 33% having a 46,XX,del(7)(q22.1q31.33) karyotype. Less than 20 cases of interstitial 7q deletions extending from bands 7q21 or 7q22 to 7q31 or 7q32 have been reported. Our patient represents the first documented case with a mosaic interstitial deletion of chromosome 7q. Furthermore, the deletion resulted in a relatively mild phenotype when compared to reported non-mosaic interstitial 7q deletions, and thus expands the range of clinical heterogeneity that can be anticipated in interstitial deletion patients.

  1. A new, highly selective CCK-B receptor radioligand (( sup 3 H)(N-methyl-Nle28,31)CCK26-33): Evidence for CCK-B receptor heterogeneity

    SciTech Connect

    Knapp, R.J.; Vaughn, L.K.; Fang, S.N.; Bogert, C.L.; Yamamura, M.S.; Hruby, V.J.; Yamamura, H.I. )

    1990-12-01

    (N-methyl-Nle28,31)CCK26-33 (SNF 8702) is a nonsulfated cholecystokinin octapeptide analog that is highly selective for cholecystokinin-B (CCK-B) receptors. Inhibition studies using (125I) Bolton-Hunter-labeled CCK-8 show that SNF 8702 has over 4,000-fold greater affinity for CCK receptors in guinea pig cortex relative to those in guinea pig pancreas. SNF 8702 was tritium-labeled to a specific activity of 23.7 Ci/mmol and its binding properties characterized for guinea pig brain membrane preparations. (3H)SNF 8702 binds to a single site with high affinity (Kd = 0.69-0.90 nM) in guinea pig cortex, cerebellum, hippocampus and pons-medulla. Of these four tissues, the highest receptor density was measured in the cortex (86 fmol/mg of protein) and the lowest in the pons-medulla (22 fmol/mg of protein). In contrast to findings of single-site binding in some brain regions, evidence for CCK-B receptor heterogeneity is observed under other conditions. (3H)SNF 8702 binding to membranes prepared from whole guinea pig brain shows biphasic association kinetics at a concentration of 2.0 nM consistent with the presence of binding site heterogeneity. Binding site heterogeneity is consistently observed for (3H)SNF 8702 binding to guinea pig whole brain membranes in saturation studies where a high-affinity site (Kd = 0.31 nM) is distinguished from a low-affinity site (Kd = 3.3 nM). Binding site heterogeneity is also observed for the midbrain-thalamic region. CCK-B receptor heterogeneity is suggested by the effect of the guanyl nucleotide analogue, guanylyl-imidodiphosphate (Gpp(NH)p), on (3H)SNF 8702 binding to CCK-B receptors in the cerebellum.

  2. Oxygen isotope ratios and rare earth elements in 3.3 to 4.4 Ga zircons: Ion microprobe evidence for high δ 18O continental crust and oceans in the Early Archean

    NASA Astrophysics Data System (ADS)

    Peck, William H.; Valley, John W.; Wilde, Simon A.; Graham, Colin M.

    2001-11-01

    Ion microprobe analyses of oxygen isotope ratios in Early Archean (Hadean) zircons (4.0- to 4.4-Ga) reveal variable magmatic δ 18O values, including some that are high relative to the mantle, suggesting interaction between magmas and already-formed continental crust during the first 500 million yr of Earth's history. The high average δ 18O value of these zircons is confirmed by conventional analysis. A metaconglomerate from the Jack Hills in the Yilgarn Craton (Western Australia) contains detrital zircons with ages > 4.0 Ga (Compston and Pidgeon, 1986) and one crystal that is 4.40-Ga old (Wilde et al., 2001). The newly discovered 4.40-Ga grain is the oldest recognized terrestrial mineral. The Jack Hills metaconglomerate also contains a large 3.3- to 3.6-Ga-old zircon population with an average δ 18O value of 6.3 ± 0.1‰ (1 s.e.,; n = 32 spot analyses). Two 4.15-Ga zircons have an average δ 18O of 5.7 ± 0.2‰ ( n = 13). In addition, a 4.13-Ga zircon has an average δ 18O of 7.2 ± 0.3‰ ( n = 8) and another 4.01-Ga zircon has an average δ 18O of 6.8 ± 0.4‰ ( n = 10). The oldest grain (4.40 Ga) is zoned with respect trace element composition (especially LREE), and intensity of cathodoluminescence, all of which correlate with oxygen isotope ratios (7.4‰ vs. 5.0‰). High LREE and high-δ 18O values from the 4.01- to 4.40-Ga grains are consistent with growth in evolved granitic magmas (δ 18O(WR) = 8.5 to 9.5‰) that had interacted with supracrustal materials. High δ 18O values show that low-temperature surficial processes (i.e., diagenesis, weathering, or low-temperature alteration) occurred before 4.0 Ga, and even before 4.40 Ga, shortly following the hypothesized date of core differentiation and impact of a Mars-sized body to form the Moon at ˜4.45 Ga. This is the first evidence of continental crust as early as 4.40 Ga and suggests differentiation during the period of intense meteorite bombardment of the early Earth. The magnitude of water and rock

  3. Asymmetric Warfare: M31 and its Satellites

    NASA Astrophysics Data System (ADS)

    Fardal, M.

    2010-06-01

    Photometric surveys of M31's halo vividly illustrate the wreckage caused by hierarchical galaxy formation. Several of M31's satellites are being disrupted by M31's tidal field, among them M33 and And I, while other tidal structures are the corpses of satellites already destroyed. The extent to which M31's satellites have left battle scars upon it is unknown; to answer this we need accurate orbits and masses of the perturbers. I focus here on M31's 150-kpc-long Giant Southern Stream (GSS) as an example of how these can be determined even in the absence of a visible progenitor. Comparing N-body models to photometric and spectroscopic data, I find this stream resulted from the disruption of a large satellite galaxy by a close passage about 750 Myr ago. The GSS is connected to several other debris structures in M31's halo. Bayesian sampling of the simulations estimates the progenitor's initial mass as M* = 109.5±0.2 Msun, showing it was one of the most massive Local Group galaxies until quite recently. The stream model constrains M31's halo mass to be ( 1.8 ± 0.5 ) × 1012 Msun. While these small uncertainties neglect several important degrees of freedom, they are likely to remain good even with a more complete model. Future work on M31 satellites and streams will provide independent constraints on M31's mass and reveal the shared history of M31 and its halo components.

  4. Structural and magnetic properties of ferromagnetic Fe1-xSix (0.18 ≤ x ≤ 0.33) films formed by rapid thermal annealing on silicon-on-insulator substrates

    NASA Astrophysics Data System (ADS)

    Nakane, R.; Sugahara, S.; Tanaka, M.

    2015-04-01

    We systematically investigate the structural and magnetic properties of ferromagnetic Fe1-xSix (0.18 ≤ x ≤ 0.33) films formed by rapid thermal annealing (RTA) on silicon-on-insulator (SOI) substrates. During RTA of an Fe film deposited on a SOI substrate (consisting of a top Si layer, a buried oxide SiO2 layer, and a Si substrate), an Fe1-xSix film is synthesized by the thermal reaction of the deposited Fe film and the top Si layer, but the reaction is limited by the buried oxide layer in the SOI substrate, thus the Si concentration x in Fe1-xSix can be controlled by both the initial thicknesses of the Fe film and the top Si layer. A variety of characteristics show that single-phase Fe1-xSix (x = 0.18, 0.22, and 0.25) films with D03 + B2 structure are successfully obtained by choosing the optimum annealing temperature and time. Furthermore, the ordering fraction of D03 and B2 structures in these films is found to be more than 87%, indicating that the crystalline quality of these films is comparable to that of bulk Fe1-xSix materials reported so far. On the other hand, it is found that the Fe1-xSix (x = 0.33) film has Fe3Si and FeSi phases as in the case of bulk Fe1-xSix with x = 0.33. The film production technique and the quality of the ferromagnetic Fe1-xSix presented in this study are very attractive and useful for silicon-based spintronic devices which are compatible with the complementary metal-oxide-semiconductor technology.

  5. Crystal-chemistry of mullite-type aluminoborates Al{sub 18}B{sub 4}O{sub 33} and Al{sub 5}BO{sub 9}: A stoichiometry puzzle

    SciTech Connect

    Fisch, Martin; Armbruster, Thomas; Rentsch, Daniel; Libowitzky, Eugen; Pettke, Thomas

    2011-01-15

    Orthorhombic Al{sub 2}O{sub 3}-rich aluminoborate is an important ceramic material for which two slightly different compositions have been assumed: Al{sub 5}BO{sub 9} (5Al{sub 2}O{sub 3}:B{sub 2}O{sub 3}) and Al{sub 18}B{sub 4}O{sub 33} (9Al{sub 2}O{sub 3}:2B{sub 2}O{sub 3}). The formula Al{sub 18}B{sub 4}O{sub 33} (=Al{sub 4.91}B{sub 1.09}O{sub 9}) was derived from results of chemical analyses when crystal structure data were not yet available. Subsequent structural investigations indicated Al{sub 5}BO{sub 9} composition. Nevertheless, Al{sub 18}B{sub 4}O{sub 33} was still accepted as the correct stoichiometry assuming that additional B replaces 9% Al. Powder samples of both compositions and ones with excess boron were prepared by solid state reactions between {alpha}-Al{sub 2}O{sub 3} and B{sub 2}O{sub 3}/H{sub 3}BO{sub 3} at temperatures above 1100 {sup o}C and single-crystals were grown from flux at 1100 and 1550 {sup o}C. Products were investigated by single-crystal and powder XRD, {sup 11}B and {sup 27}Al solid-state MAS-NMR, Raman and FTIR spectroscopy as well as Laser-ablation ICP-MS. No indication of the predicted 9% B{yields}Al substitution was found. LA ICP-MS indicated 12.36(27) wt% B{sub 2}O{sub 3} corresponding to Al{sub 4.97}B{sub 1.03}O{sub 9}. Hence, the suggested Al{sub 18}B{sub 4}O{sub 33} stoichiometry can be excluded for all synthesized samples. A very low amount of Al vacancies at a five-fold coordinated site are likely, charge balanced by an additional nearby three-fold coordinated B site. All evidences indicate that the title compound should be reported as Al{sub 5-x}B{sub 1+x}O{sub 9} with x<0.038(6), which is close to Al{sub 5}BO{sub 9}. -- Graphical abstract: A chemical composition of Al{sub 18}B{sub 4}O{sub 33}=Al{sub 4.91}B{sub 1.09}O{sub 9}=9Al{sub 2}O{sub 3}:2B{sub 2}O{sub 3} has been assumed for mullite-type aluminoborate with Al{sub 5}BO{sub 9} structure. However, samples prepared by different routes showed compositions close to 5Al

  6. Microstructural Characterization of a Directionally-Solidified Ni-33 (at. %)Al-31Cr-3Mo Eutectic Alloy as a Function of Withdrawal Rate

    NASA Technical Reports Server (NTRS)

    Raj, S. V.; Locci, I. E.; Whittenberger, J. D.; Salem, J. A.

    2000-01-01

    The Ni-33 (at. %)Al-3lCr-3Mo eutectic alloy was directionally-solidified (DS) at different rates, V(sub I), varying between 2.5 to 508 mm/ h. Detailed qualitative and quantitative metallographic and chemical analyses were conducted on the directionally-solidified rods. The microstructures consisted of eutectic colonies with parallel lamellar NiAl/(Cr,Mo) plates for solidification rates at and below 12.7 mm/ h. Cellular eutectic microstructures were observed at higher solidification rates, where the plates exhibited a radial pattern. The microstructures were demonstrated to be fairly uniform throughout a 100 mm length of the DS zone by quantitative metallography. The average cell size, bar-d, decreased with increasing growth rate to a value of 125 microns at 508 mm/ h according to the relation bar-d (microns) approx. = 465 V(sup -0.22, sub I), where V(sub I) is in mm/ h. Both the average NiAl plate thickness, bar-Delta(sub NiAl), and the interlamellar spacing, bar-lambda, were observed to be constant for V(sub I) less than or = 50.8 mm/ h but decreased with increasing growth rate above this value as 0.93 bar-Delta(sub NiAl)(microns) = 61.2 V(sup -0.93, sub I) and bar-lambda (microns) = 47.7 V(sup -0.64, sub I), respectively. The present results are detailed on a microstructural map. Keywords Optical microscopy, microstructure, compounds intermetallic, directional solidification

  7. Microbial processes dominate P fluxes in a low-phosphorus temperate forest soil: insights provided by 33P and 18O in phosphate

    NASA Astrophysics Data System (ADS)

    Pistocchi, Chiara; Tamburini, Federica; Bünemann, Else; Mészáros, Éva; Frossard, Emmanuel

    2016-04-01

    The classical view of the P cycle in forests is that trees and mycorrhizal fungi associated with them take up most of their phosphorus as phosphate (P) from the soil solution. The soil solution is then replenished by the release of P from sorbed phases, by the dissolution of P containing minerals or by biological mineralization and/or enzymatic hydrolysis of organic P compounds. Direct insight into the processes phosphate goes through at the ecosystem level is, however, missing. Assessing the relevance of inorganic and biological processes controlling P cycling requires the use of appropriate approaches and tracers. Within the German Priority Program "Ecosystem Nutrition: Forest Strategies for limited Phosphorus Resources" we studied P forms and dynamics in organic horizons (Of/Oh) of temperate beech forest soils in Germany with contrasting soil P availability (P-poor and P-rich). We followed the fate of P from the litter into the soil pools, using isotopes as tracers (stable oxygen isotopes in water and phosphate and 33P) and relied on measurements in experimental forest sites and a three-months incubation experiment with litter addition. Using an isotopic dilution approach we were able to estimate gross (7 mg P kg-1 d-1 over the first month) and net mineralization rates (about 5 mg P kg-1 d-1 over the first 10 days) in the P-poor soil. In this soil the immobilization of P in the microbial biomass ranged from 20 to 40% of gross mineralization during the incubation, meaning that a considerable part of mineralized P contributed to replenish the available P pool. In the P-rich soil, physicochemical processes dominated exchangeable P to the point that the contribution of biological/biochemical processes was non-detectable. Oxygen isotopes in phosphate elucidated that organic P mineralization by enzymatic hydrolysis gains more importance with decreasing P availability, both under controlled and under field conditions. In summary, microbial processes dominated P fluxes

  8. (Fluorine-18 labeled androgens and progestins; imaging agents for tumors of prostate and breast): Technical progress report, February 1, 1987-January 31, 1988

    SciTech Connect

    Katzenellenbogen, J.A.

    1987-01-01

    This project develops fluorine-18 labeled steroids that possess high binding affinity and selectivity for androgen and progesterone receptors and can be used as positron-emission tomographic imaging agents for prostate tumors and breast tumors, respectively. These novel diagnostic agents may enable an accurate estimation of tumor dissemination, such as metastasis of prostate cancer and lymph node involvement of breast cancer, and an in vivo determination of the endocrine responsiveness of these tumors. They will provide essential information for the selection of alternative therapies thereby improving the management of prostate and breast cancer patients. 14 refs., 1 tab.

  9. Growth of single-crystal Ca10(Pt4As8)(Fe(1.8)Pt(0.2)As2)5 nanowhiskers with superconductivity up to 33 K.

    PubMed

    Li, Jun; Yuan, Jie; Tang, Dai-Ming; Zhang, Shou-Bao; Li, Meng-Yue; Guo, Yan-Feng; Tsujimoto, Yoshihiro; Hatano, Takeshi; Arisawa, Shunichi; Golberg, Dmitri; Wang, Hua-Bing; Yamaura, Kazunari; Takayama-Muromachi, Eiji

    2012-03-07

    Single-crystal Ca(10)(Pt(4)As(8))(Fe(1.8)Pt(0.2)As(2))(5) superconducting (SC) nanowhiskers with widths down to hundreds of nanometers were successfully grown in a Ta capsule in an evacuated quartz tube by a flux method. Magnetic and electrical properties measurements demonstrate that the whiskers have excellent crystallinity with critical temperature of up to 33 K, upper critical field of 52.8 T, and critical current density of J(c) of 6.0 × 10(5) A/cm(2) (at 26 K). Since cuprate high-T(c) SC whiskers are fragile ceramics, the present intermetallic SC whiskers with high T(c) have better opportunities for device applications. Moreover, although the growth mechanism is not understood well, the technique can be potentially useful for growth of other whiskers containing toxic elements.

  10. Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis

    PubMed Central

    Busbee, Philip B.; Nagarkatti, Mitzi; Nagarkatti, Prakash S.

    2015-01-01

    Staphylococcal enterotoxin B (SEB) is a potent superantigen capable of inducing inflammation characterized by robust immune cell activation and proinflammatory cytokine release. Exposure to SEB can result in food poisoning as well as fatal conditions such as toxic shock syndrome. In the current study, we investigated the effect of natural indoles including indole-3-carbinol (I3C) and 3,3’-diindolylmethane (DIM) on SEB-mediated liver injury. Injection of SEB into D-galactosamine-sensitized female C57BL/6 mice resulted in liver injury as indicated by an increase in enzyme aspartate transaminase (AST) levels, induction of inflammatory cytokines, and massive infiltration of immune cells into the liver. Administration of I3C and DIM (40mg/kg), by intraperitonal injection, attenuated SEB-induced acute liver injury, as evidenced by decrease in AST levels, inflammatory cytokines and cellular infiltration in the liver. I3C and DIM triggered apoptosis in SEB-activated T cells primarily through activation of the intrinsic mitochondrial pathway. In addition, inhibitor studies involving caspases revealed that I3C and DIM-mediated apoptosis in these activated cells was dependent on caspase-2 but independent of caspase-8, 9 and 3. In addition, I3C and DIM caused a decrease in Bcl-2 expression. Both compounds also down-regulated miR-31, which directly targets caspase-2 and influences apoptosis in SEB-activated cells. Our data demonstrate for the first time that indoles can effectively suppress acute hepatic inflammation caused by SEB and that this may be mediated by decreased expression of miR-31 and consequent caspase-2-dependent apoptosis in T cells. PMID:25706292

  11. Lessons-Learned from D and D Activities at the Five Gaseous Diffusion Buildings (K-25, K- 27, K-29, K-31 and K-33) East Tennessee Technology Park, Oak Ridge, TN - 13574

    SciTech Connect

    Kopotic, James D.; Ferri, Mark S.; Buttram, Claude

    2013-07-01

    The East Tennessee Technology Park (ETTP) is the site of five former gaseous diffusion plant (GDP) process buildings that were used to enrich uranium from 1945 to 1985. The process equipment in the original two buildings (K-25 and K-27) was used for the production of highly enriched uranium (HEU), while that in the three later buildings (K-29, K-31 and K-33) produced low enriched uranium (LEU). Equipment was contaminated primarily with uranium and to a lesser extent technetium (Tc). Decommissioning of the GDP process buildings has presented several unique challenges and produced many lessons-learned. Among these is the importance of good, up-front characterization in developing the best demolition approach. Also, chemical cleaning of process gas equipment and piping (PGE) prior to shutdown should be considered to minimize the amount of hold-up material that must be removed by demolition crews. Another lesson learned is to maintain shutdown buildings in a dry state to minimize structural degradation which can significantly complicate characterization, deactivation and demolition efforts. Perhaps the most important lesson learned is that decommissioning GDP process buildings is first and foremost a waste logistics challenge. Innovative solutions are required to effectively manage the sheer volume of waste generated from decontamination and demolition (D and D) of these enormous facilities. Finally, close coordination with Security is mandatory to effectively manage Special Nuclear Material (SNM) and classified equipment issues. (authors)

  12. Task 3.0 -- Advanced power systems: Subtask 3.18 -- Ash behavior in power systems. Semi-annual report, June 1--December 31, 1997

    SciTech Connect

    Zygarlicke, C.J.; McCollor, D.P.; Folkedahl, B.C.; Swanson, M.L.; Musich, M.A.

    1998-10-01

    Advanced power systems such as integrated gasifier combined cycle systems and fluidized bed systems are at the forefront of power industry research because of the need for increased efficiency and the reduction of greenhouse gases. Ash behavior in power systems can have a significant impact on the design and performance of these systems. The Energy and Environmental Research Center (EERC) has developed a focused research initiative aimed at filling gaps in the understanding of fundamental mechanisms of ash behavior, which has relevance to commercial application and marketable products associated with advanced power systems. This program develops methods and means to better understand and mitigate adverse coal ash behavior in advanced power systems and can act to relieve the US reliance on diminishing recoverable oil resources and other greenhouse-producing fossil fuels. Subtask 3.18 is structured as three tasks. Task 1 pertains to summarizing the critical issues in ash behavior, especially for advanced power systems. Task 2 focuses on fundamental ash sintering and viscosity-ash composition relationships that are critical for developing a better mechanistic understanding of ash deposit formation and for predicting ash behavior. Task 3 is aimed primarily at determining the role of the ash chemistry and phase relationships for specific ash interactions in advanced power systems. The role of sulfides in the formation of ash deposits in gasification systems and the factors that influence alloy corrosion in supercritical boilers will be specifically analyzed. Task results to date are presented.

  13. 33 CFR 203.31 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Emergency operations under Public Law 84-99 apply to Flood Response and Post Flood Response activities. Flood Response activities include flood fighting, rescue operations, and protection of Corps-constructed... such agencies have emergency flood fighting authority. Further, Flood Response measures...

  14. 33 CFR 203.31 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Emergency operations under Public Law 84-99 apply to Flood Response and Post Flood Response activities. Flood Response activities include flood fighting, rescue operations, and protection of Corps-constructed... such agencies have emergency flood fighting authority. Further, Flood Response measures...

  15. 33 CFR 203.31 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... intended to prevent imminent loss of life or significant public property, or to protect against significant..., polyethylene sheeting, or stone; lending of Corps-owned equipment; hiring of equipment and operators for flood... assistance required to prevent imminent loss of life or significant damage to public property, or to...

  16. 33 CFR 203.31 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... intended to prevent imminent loss of life or significant public property, or to protect against significant..., polyethylene sheeting, or stone; lending of Corps-owned equipment; hiring of equipment and operators for flood... assistance required to prevent imminent loss of life or significant damage to public property, or to...

  17. 32 CFR 33.31 - Real property.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... purchase to the fair market value of the property. However, in those situations where a grantee or... practicable and result in the highest possible return. (3) Transfer of title. Transfer title to the awarding... purchase of the real property to the current fair market value of the property....

  18. 31 CFR 16.33 - Witnesses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... control over the mode and order of interrogating witnesses and presenting evidence so as to— (1) Make the interrogation and presentation effective for the ascertainment of the truth, (2) Avoid needless consumption...

  19. 33 CFR 203.31 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Assistance from the Corps may include the following: provision of technical advice and assistance; cleaning... debris blockages of critical water supply intakes, sewer outfalls, etc.; clearance of the minimum...

  20. 31 CFR 33.108 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) A detailed 10-year budget plan that is deficit neutral to the Federal government, as prescribed by... prohibited under section 1332(b)(1)(D) of the Affordable Care Act (the Federal deficit requirement), will not increase the Federal deficit. (4) Contains the following supporting information: (i) Actuarial analyses...

  1. 31 CFR 33.108 - Application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) A detailed 10-year budget plan that is deficit neutral to the Federal government, as prescribed by... prohibited under section 1332(b)(1)(D) of the Affordable Care Act (the Federal deficit requirement), will not increase the Federal deficit. (4) Contains the following supporting information: (i) Actuarial analyses...

  2. 31 CFR 33.108 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) A detailed 10-year budget plan that is deficit neutral to the Federal government, as prescribed by... prohibited under section 1332(b)(1)(D) of the Affordable Care Act (the Federal deficit requirement), will not increase the Federal deficit. (4) Contains the following supporting information: (i) Actuarial analyses...

  3. Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia.

    PubMed

    Kalantari, Mina; Osann, Kathryn; Calleja-Macias, Itzel E; Kim, Seong; Yan, Bing; Jordan, Sara; Chase, Dana M; Tewari, Krishnansu S; Bernard, Hans-Ulrich

    2014-01-05

    During progression of cervical cancer, human papillomavirus genomes and cellular tumor suppressor genes can become methylated. Toward a better understanding of these biomarkers, we studied 104 samples with HPV16, 18, 31, and 45 representing five pathological categories from asymptomatic infection to cancer. We grouped all samples by HPV type and pathology and measured the overall methylation of informative amplicons of HPV late genes and the cellular DAPK gene. Methylation of all four HPV types as well as of the DAPK gene is lowest in asymptomatic infection and increases successively in all four pathological categories during progression to cancer. 27 out of 28 cancer samples showed methylation both in the L2/L1 genes as well as in DAPK, but a much lower fraction in all other pathological categories. We discuss the problem to develop diagnostic tests based on complex methylation patterns that make it difficult to classify amplicons as "methylated" or "unmethylated".

  4. 33 CFR 385.18 - Public outreach.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... process. (4) Project Management Plans and Program Management Plans shall include information concerning... opportunities to review and comment during implementation of the Plan. (3) Project Management Plans and Program... conduct outreach activities for project or program-level activities in order to provide information to...

  5. 33 CFR 385.18 - Public outreach.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... process. (4) Project Management Plans and Program Management Plans shall include information concerning... opportunities to review and comment during implementation of the Plan. (3) Project Management Plans and Program... conduct outreach activities for project or program-level activities in order to provide information to...

  6. 33 CFR 385.18 - Public outreach.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... process. (4) Project Management Plans and Program Management Plans shall include information concerning... opportunities to review and comment during implementation of the Plan. (3) Project Management Plans and Program... conduct outreach activities for project or program-level activities in order to provide information to...

  7. 33 CFR 385.18 - Public outreach.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... process. (4) Project Management Plans and Program Management Plans shall include information concerning... opportunities to review and comment during implementation of the Plan. (3) Project Management Plans and Program... conduct outreach activities for project or program-level activities in order to provide information to...

  8. 33 CFR 161.18 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... time group expressed as in (B). J JULIET Pilot State whether a deep sea or local pilot is on board. K... overboard; position expressed as in (C) or (D). S SIERRA Weather conditions Brief details of weather and...

  9. 33 CFR 385.18 - Public outreach.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... communities and traditionally under served communities, persons with limited English proficiency, and socially... individuals with limited English proficiency, and communities are provided opportunities to review and comment... individuals and communities, including individuals with limited English proficiency, are...

  10. 33 CFR 161.18 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ALPHA Ship Name, call sign or ship station identity, and flag. B BRAVO Dates and time of event A 6 digit... designated in Table 161.12(c) (VTS and VMRS Centers, Call Signs/MMSI, Designated Frequencies, and Monitoring..., Call Signs/MMSI, Designated Frequencies, and Monitoring Areas). In addition, the VMRS User must...

  11. 33 CFR 161.18 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ALPHA Ship Name, call sign or ship station identity, and flag. B BRAVO Dates and time of event A 6 digit... designated in Table 161.12(c) (VTS and VMRS Centers, Call Signs/MMSI, Designated Frequencies, and Monitoring..., Call Signs/MMSI, Designated Frequencies, and Monitoring Areas). In addition, the VMRS User must...

  12. 33 CFR 161.18 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ALPHA Ship Name, call sign or ship station identity, and flag. B BRAVO Dates and time of event A 6 digit... designated in Table 161.12(c) (VTS and VMRS Centers, Call Signs/MMSI, Designated Frequencies, and Monitoring..., Call Signs/MMSI, Designated Frequencies, and Monitoring Areas). In addition, the VMRS User must...

  13. Pericentric inversion of chromosome 18 in parents leading to a phenotypically normal child with segmental uniparental disomy 18.

    PubMed

    Kariminejad, Ariana; Kariminejad, Roxana; Moshtagh, Azadeh; Zanganeh, Maryam; Kariminejad, Mohammad Hassan; Neuenschwander, Stefan; Okoniewski, Michal; Wey, Eva; Schinzel, Albert; Baumer, Alessandra

    2011-05-01

    In this study, we report a familial inversion of chromosome 18, inv(18)(p11.31q21.33), in both members of a consanguineous couple. Their first child had inherited one balanced pericentric inversion along with a recombinant chromosome 18 resulting in dup(18q)/del(18p), and had mild dysmorphic features in the absence of mental and developmental retardation. The second child had received two recombinant chromosomes 18, from the mother a derivative chromosome 18 with dup(18p)/del(18q) and from the father a derivative chromosome 18 with dup(18q)/del(18p). The aberration was prenatally detected; however, as the two opposite aneuploidies were thought to compensate each other, the family decided to carry on with the pregnancy, knowing that uniparental disomy for the segments outside the inversion could have an adverse influence on the development of the child. Uniparental disomy was confirmed by SNP arrays. The child, who has been followed up until the age of 20 months, is healthy and normal. It seems to be the first reported case with two opposite recombinant chromosomes that compensate each other and lead to segmental uniparental disomy for two segments on the chromosome, one maternal and the other paternal.

  14. Pericentric inversion of chromosome 18 in parents leading to a phenotypically normal child with segmental uniparental disomy 18

    PubMed Central

    Kariminejad, Ariana; Kariminejad, Roxana; Moshtagh, Azadeh; Zanganeh, Maryam; Kariminejad, Mohammad Hassan; Neuenschwander, Stefan; Okoniewski, Michal; Wey, Eva; Schinzel, Albert; Baumer, Alessandra

    2011-01-01

    In this study, we report a familial inversion of chromosome 18, inv(18)(p11.31q21.33), in both members of a consanguineous couple. Their first child had inherited one balanced pericentric inversion along with a recombinant chromosome 18 resulting in dup(18q)/del(18p), and had mild dysmorphic features in the absence of mental and developmental retardation. The second child had received two recombinant chromosomes 18, from the mother a derivative chromosome 18 with dup(18p)/del(18q) and from the father a derivative chromosome 18 with dup(18q)/del(18p). The aberration was prenatally detected; however, as the two opposite aneuploidies were thought to compensate each other, the family decided to carry on with the pregnancy, knowing that uniparental disomy for the segments outside the inversion could have an adverse influence on the development of the child. Uniparental disomy was confirmed by SNP arrays. The child, who has been followed up until the age of 20 months, is healthy and normal. It seems to be the first reported case with two opposite recombinant chromosomes that compensate each other and lead to segmental uniparental disomy for two segments on the chromosome, one maternal and the other paternal. PMID:21326286

  15. 40 CFR 792.33 - Study director.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Study director. 792.33 Section 792.33...) GOOD LABORATORY PRACTICE STANDARDS Organization and Personnel § 792.33 Study director. For each study... thereof, shall be identified as the study director. The study director has overall responsibility for...

  16. 34 CFR 33.4 - Investigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Investigation. 33.4 Section 33.4 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.4 Investigation. (a) If... conclusions of the investigation to the reviewing official. (Authority: 31 U.S.C. 3803(a)(1)) (c) Nothing...

  17. 34 CFR 33.4 - Investigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Investigation. 33.4 Section 33.4 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.4 Investigation. (a) If... conclusions of the investigation to the reviewing official. (Authority: 31 U.S.C. 3803(a)(1)) (c) Nothing...

  18. 34 CFR 33.4 - Investigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Investigation. 33.4 Section 33.4 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.4 Investigation. (a) If... conclusions of the investigation to the reviewing official. (Authority: 31 U.S.C. 3803(a)(1)) (c) Nothing...

  19. 34 CFR 33.4 - Investigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Investigation. 33.4 Section 33.4 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.4 Investigation. (a) If... conclusions of the investigation to the reviewing official. (Authority: 31 U.S.C. 3803(a)(1)) (c) Nothing...

  20. 34 CFR 33.4 - Investigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Investigation. 33.4 Section 33.4 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.4 Investigation. (a) If... conclusions of the investigation to the reviewing official. (Authority: 31 U.S.C. 3803(a)(1)) (c) Nothing...

  1. 34 CFR 33.42 - Judicial review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Judicial review. 33.42 Section 33.42 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.42 Judicial review. Section 3805 of title 31, United States Code, authorizes judicial review by an appropriate United...

  2. Synthesis, structural characterization, electrical properties and antioxidant activity of [p-(NH3)C6H4NH3]3P6O18·6H2O

    NASA Astrophysics Data System (ADS)

    Fezai, Ramzi; Mezni, Ali; Kahlaoui, Messaoud; Rzaigui, Mohamed

    2016-09-01

    Single crystals of a novel organic cyclohexaphosphate, [p-(NH3)C6H4NH3]3P6O18.6H2O, have been prepared in aqueous solution. Its crystal structure can be described by a three-dimensional framework where the P6O186- rings are interconnected by hydrogen bonds to form anionic layers between which organic cations are located. Hydrogen bonding network connecting the different components is given. The thermal stability and spectroscopic properties of this material are given too. Its DC and AC electrical conductivities, modulus analysis and dielectric constants have been investigated. The AC conductivity is found to obey the universal power law. The DC electrical conductivity indicates a semiconductor behavior. The kind of the observed conduction is protonic by translocation. X-rays structural and electrical results are correlated. This compound has also been screened for its antioxidant activity, determined in vitro, using 1,1-diphenyl-2-picrylhydrazyl, reducing power, hydroxyl scavenging ability and ferrous ion chelating (FIC) methods and with ascorbic acid as reference.

  3. The effects of annealing on the microstructure and mechanical properties of Fe28Ni18Mn33Al21

    SciTech Connect

    Meng, Fanling; Qiu, Jingwen; Baker, Ian; Bei, Hongbin

    2015-08-20

    In this paper, As-cast Fe28Ni18Mn33Al21, which consists of aligned, 50 nm, (Ni, Al)-rich B2, and (Fe, Mn)-rich f.c.c. phases, was annealed at a variety of temperatures up to 1423 K and the microstructure and mechanical properties were examined. It was shown that the as-cast microstructure arises from a eutectoid transformation at ~1300 K. Annealing at temperatures ≤1073 K produces β-Mn-structured precipitates and hardness values up to 816 HV, while annealing at temperatures >1073 K leads to dramatic coarsening of the two-phase B2/f.c.c. microstructure (up to 5.5 µm after 50 h at 1273 K), but does not lead to β-Mn precipitation. Interestingly, annealing at temperatures >1073 K delays the onset of β-Mn precipitation during subsequent anneals at lower temperatures. Coarsening the B2/f.c.c. lamellar structure by annealing at higher temperatures softens it and leads to increases in ductility from fracture before yield to ~8 % elongation. Finally, the presence of β-Mn precipitates makes the very fine, brittle B2/f.c.c. microstructures even more brittle, but significant ductility (8.4 % elongation) is possible even with β-Mn precipitates present if the B2/f.c.c. matrix is coarse and, hence, more ductile.

  4. Effects of cation-size disorder in (La0.67Ca0.15Sr0.18)1-x(Gd0.67Ba0.33)xCoO3 perovskites

    NASA Astrophysics Data System (ADS)

    Sun, J. R.; Wong, H. K.

    1999-07-01

    Effects of the A-cation disorder on the structural, magnetic and transport properties of the ABO3-type (La0.67Ca0.15Sr0.18)1-x(Gd0.67Ba0.33)xCoO3 (x=0.0, 0.1, 0.2, 0.3, and 0.4) are studied. Based on x-ray diffraction, two crystallographic phases coexist in the compounds, and a progressive transition from rhombohedral structure to orthorhombic structure takes place with increasing x, with which the cation disorder increases. Two resistive transitions, a metal-to-metal and a metal-to-semiconductor, occur subsequently with decreasing temperature, with the upper resistive transition coinciding with a magnetic one. Both resistive transitions vary against x, with the upper one from ~223 to ~190 K and the lower one from ~95 to ~160 K corresponding to a change of x from 0.0-0.3. The presence of cation-size disorder drives the system from the cluster-glass state into the spin-glass state, accompanied by an enhancement of the semiconducting character of the compounds. The weak Jahn-Teller effects and the spin state transition could be responsible for the special cation disorder effects in the Co-based perovskites.

  5. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  6. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  7. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  8. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  9. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  10. 18 CFR 157.31 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) “Voluntary expansion” means any expansion in capacity of an Alaska natural gas transportation project above... certificate order, voluntarily made by the pipeline. An expansion done pursuant to section 105 of the Alaska Natural Gas Pipeline Act is not a voluntary expansion....

  11. 49 CFR 18.31 - Real property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... sale after deduction of any actual and reasonable selling and fixing-up expenses. If the grant is still... of right-of-way and other items when certain segments of the Interstate System are withdrawn....

  12. 18 CFR 415.31 - Prohibited uses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., fill or solid waste. (3) Stockpiling or disposal of pesticides, domestic or industrial waste... the basin. (4) The storage of equipment or of buoyant materials, except for purposes of public safety...: (1) Stockpiling or disposal of pesticides, domestic or industrial waste, radioactive...

  13. 18 CFR 415.31 - Prohibited uses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., fill or solid waste. (3) Stockpiling or disposal of pesticides, domestic or industrial waste... the basin. (4) The storage of equipment or of buoyant materials, except for purposes of public safety...: (1) Stockpiling or disposal of pesticides, domestic or industrial waste, radioactive...

  14. 18 CFR 415.31 - Prohibited uses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., fill or solid waste. (3) Stockpiling or disposal of pesticides, domestic or industrial waste... the basin. (4) The storage of equipment or of buoyant materials, except for purposes of public safety...: (1) Stockpiling or disposal of pesticides, domestic or industrial waste, radioactive...

  15. 30 CFR 203.33 - To which production do I apply the RSV earned by qualified phase 2 and phase 3 ultra-deep wells...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... REVENUE MANAGEMENT RELIEF OR REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General § 203.33 To which... unit? (a) You must apply the RSV allowed in § 203.31(a) and (b) to gas volumes produced from qualified wells on or after May 18, 2007, reported on the Oil and Gas Operations Report, Part A (OGOR-A) for...

  16. 30 CFR 203.33 - To which production do I apply the RSV earned by qualified phase 2 and phase 3 ultra-deep wells...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... REVENUE MANAGEMENT RELIEF OR REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General § 203.33 To which... unit? (a) You must apply the RSV allowed in § 203.31(a) and (b) to gas volumes produced from qualified wells on or after May 18, 2007, reported on the Oil and Gas Operations Report, Part A (OGOR-A) for...

  17. 30 CFR 203.33 - To which production do I apply the RSV earned by qualified phase 2 and phase 3 ultra-deep wells...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... REVENUE MANAGEMENT RELIEF OR REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General § 203.33 To which... unit? (a) You must apply the RSV allowed in § 203.31(a) and (b) to gas volumes produced from qualified wells on or after May 18, 2007, reported on the Oil and Gas Operations Report, Part A (OGOR-A) for...

  18. Luminous and Variable Stars in M31 and M33. IV. Luminous Blue Variables, Candidate LBVs, B[e] Supergiants, and the Warm Hypergiants: How to Tell Them Apart

    NASA Astrophysics Data System (ADS)

    Humphreys, Roberta M.; Gordon, Michael S.; Martin, John C.; Weis, Kerstin; Hahn, David

    2017-02-01

    In this series of papers we have presented the results of a spectroscopic survey of luminous stars in the nearby spirals M31 and M33. Here, we present spectroscopy of 132 additional stars. Most have emission-line spectra, including luminous blue variables (LBVs) and candidate LBVs, Fe ii emission line stars, the B[e] supergiants, and the warm hypergiants. Many of these objects are spectroscopically similar and are often confused with each other. We examine their similarities and differences and propose the following guidelines that can be used to help distinguish these stars in future work. (1) The B[e] supergiants have emission lines of [O i] and [Fe ii] in their spectra. Most of the spectroscopically confirmed sgB[e] stars also have warm circumstellar dust in their spectral energy distributions (SEDs). (2) Confirmed LBVs do not have the [O i] emission lines in their spectra. Some LBVs have [Fe ii] emission lines, but not all. Their SEDs show free–free emission in the near-infrared but no evidence for warm dust. Their most important and defining characteristic is the S Dor-type variability. (3) The warm hypergiants spectroscopically resemble the LBVs in their dense wind state and the B[e] supergiants. However, they are very dusty. Some have [Fe ii] and [O i] emission in their spectra like the sgB[e] stars, but are distinguished by their A- and F-type absorption-line spectra. In contrast, the B[e] supergiant spectra have strong continua and few if any apparent absorption lines. Candidate LBVs should share the spectral characteristics of the confirmed LBVs with low outflow velocities and the lack of warm circumstellar dust. Based on observations with the Multiple Mirror Telescope, a joint facility of the Smithsonian Institution and the University of Arizona and on observations obtained with the Large Binocular Telescope (LBT), an international collaboration among institutions in the United States, Italy, and Germany. LBT Corporation partners are The University of

  19. 34 CFR 674.31 - Promissory note.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Promissory note. 674.31 Section 674.31 Education..., DEPARTMENT OF EDUCATION FEDERAL PERKINS LOAN PROGRAM Terms of Loans § 674.31 Promissory note. (a) Promissory... monthly repayment amount if the institution chooses the option under § 674.33(b). (b) Provisions of...

  20. 14 CFR 33.33 - Vibration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Vibration. 33.33 Section 33.33 Aeronautics... STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.33 Vibration. The... vibration and without imparting excessive vibration forces to the aircraft structure....

  1. 14 CFR 33.33 - Vibration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Vibration. 33.33 Section 33.33 Aeronautics... STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.33 Vibration. The... vibration and without imparting excessive vibration forces to the aircraft structure....

  2. 14 CFR 33.33 - Vibration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Vibration. 33.33 Section 33.33 Aeronautics... STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.33 Vibration. The... vibration and without imparting excessive vibration forces to the aircraft structure....

  3. 14 CFR 33.33 - Vibration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Vibration. 33.33 Section 33.33 Aeronautics... STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.33 Vibration. The... vibration and without imparting excessive vibration forces to the aircraft structure....

  4. 14 CFR 33.33 - Vibration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Vibration. 33.33 Section 33.33 Aeronautics... STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.33 Vibration. The... vibration and without imparting excessive vibration forces to the aircraft structure....

  5. 12 CFR 3.3 - Transitional rules.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Transitional rules. 3.3 Section 3.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MINIMUM CAPITAL RATIOS; ISSUANCE OF... December 31, 1992, only those intangible assets that meet the criteria contained in section 2(c)(2)...

  6. 12 CFR 3.3 - Transitional rules.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Transitional rules. 3.3 Section 3.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MINIMUM CAPITAL RATIOS; ISSUANCE OF... December 31, 1992, only those intangible assets that meet the criteria contained in section 2(c)(2)...

  7. Chemical Evolution Model of M33

    NASA Astrophysics Data System (ADS)

    Robles-Valdez, F.; Carigi, L.

    2011-10-01

    We present a chemical evolution model (CEM) of M33 and we find that M33, which is smaller than both M31 and MW, shows a lower gas infall rate, SFR efficiency, and IMF M_{up}. Therefore the CEMs for large spiral galaxies (Carigi et al. 2005; Meneses-Goytia et al. 2011) can be scaled to a smaller galaxy.

  8. 40 CFR 610.33 - Durability tests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Durability tests. 610.33 Section 610... RETROFIT DEVICES Test Procedures and Evaluation Criteria Test Requirement Criteria § 610.33 Durability tests. The Administrator may determine that a device under evaluation will require durability testing...

  9. X-31 wing removal

    NASA Technical Reports Server (NTRS)

    1995-01-01

    U.S. and German personnel of the X-31 Enhanced Fighter Maneuverability Technology Demonstrator aircraft program removing the right wing of the aircraft, which was ferried from Edwards Air Force Base, California, to Europe on May 22, 1995 aboard an Air Force Reserve C-5 transport. The X-31, based at the NASA Dryden Flight Research Center was ferried to Europe and flown in the Paris Air Show in June. The wing of the X-31 was removed on May 18, 1995, to allow the aircraft to fit inside the C-5 fuselage. Officials of the X-31 project used Manching, Germany, as a staging base to prepare the aircraft for the flight demonstration. At the air show, the X-31 demonstrated the value of using thrust vectoring (directing engine exhaust flow) coupled with advanced flight control systems to provide controlled flight at very high angles of attack. The aircraft arrived back at Edwards in a Air Force Reserve C-5 on June 25, 1995 and off loaded at Dryden June 27. The X-31 aircraft was developed jointly by Rockwell International's North American Aircraft Division (now part of Boeing) and Daimler-Benz Aerospace (formerly Messerschmitt-Bolkow-Blohm), under sponsorship by the U.S. Department of Defense and The German Federal Ministry of Defense.

  10. 14 CFR 31.31 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false General. 31.31 Section 31.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.31 General. The suitability of each design...

  11. 14 CFR 31.31 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false General. 31.31 Section 31.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.31 General. The suitability of each design...

  12. 14 CFR 31.31 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false General. 31.31 Section 31.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.31 General. The suitability of each design...

  13. 14 CFR 31.31 - General.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false General. 31.31 Section 31.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.31 General. The suitability of each design...

  14. 14 CFR 31.31 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false General. 31.31 Section 31.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.31 General. The suitability of each design...

  15. Differences in incidence and co-occurrence of vaccine and nonvaccine human papillomavirus types in Finnish population before human papillomavirus mass vaccination suggest competitive advantage for HPV33.

    PubMed

    Merikukka, Marko; Kaasila, Marjo; Namujju, Proscovia B; Palmroth, Johanna; Kirnbauer, Reinhard; Paavonen, Jorma; Surcel, Heljä-Marja; Lehtinen, Matti

    2011-03-01

    To understand likelihood of type replacement after vaccination against the high-risk human papillomavirus (HPV) types, we evaluated competition of the seven most common genital HPV types in a population sample of unvaccinated, fertile-aged Finnish women. First trimester sera from two consecutive pregnancies were retrieved from 3,183 Finnish women (mean age, 23.1 years) of whom 42.3% had antibodies to at least one HPV type (6/11/16/18/31/33/45) at the baseline. Antibody positivity to more than one HPV types by the second pregnancy was common among the baseline HPV seropositives. However, compared to baseline HPV-seronegative women, significantly increased incidence rate ratios (IRRs), indicating an increased risk to seroconvert for another HPV type, were consistently noted only for HPV33 among baseline HPV16 or HPV18 antibody (ab)-positive women: HPV(16ab only) (→) (16&33ab) IRR 2.9 [95% confidence interval (CI) 1.6-5.4] and HPV(18ab only) (→) (18&33ab) IRR 2.5 (95% CI 1.1-6.0), irrespectively of the presence of antibodies to other HPV types at baseline: HPV(16ab) (→) (16&33ab) IRR 3.2 (95% CI 2.0-5.2) and HPV(18ab) (→) (18&33ab) IRR 3.6 (95% CI 2.1-5.9). Our findings suggest a possible competitive advantage for HPV33 over other genital HPV types in the unvaccinated population. HPV33 should be monitored for type replacement after HPV mass vaccination.

  16. Development of an integrated in-situ remediation technology. Draft topical report for Task {number_sign}3.3 entitled, ``Iron dechlorination studies`` (September 26, 1994--August 31, 1997)

    SciTech Connect

    Orth, R.; Dauda, T.; McKenzie, D.E.

    1997-11-01

    Contamination in low-permeability soils poses a significant technical challenge to in-situ remediation efforts. Poor accessibility to the contaminants and difficulty in delivery of treatment reagents have rendered existing in-situ treatments such as bioremediation, vapor extraction, and pump and treat rather ineffective when applied to low permeability soils present at many contaminated sites. The technology is an integrated in-situ treatment in which established geotechnical methods are used to install degradation zones directly in the contaminated soil and electro-osmosis is utilized to move the contaminants back and forth through those zones until the treatment is completed. The present Topical Report for Task {number_sign}3.3 summarizes the iron dechlorination research conducted by Monsanto Company.

  17. Trisomy 18

    MedlinePlus

    ... bone. Chromosome studies will show trisomy 18. The chromosome abnormality may be present in every cell or present in only a certain percentage of the cells (called mosaicism). ... of the chromosome in some cells. Rarely, part of the chromosome ...

  18. 40 CFR 721.3025 - Fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acids C12-18, C18 unsaturated... Significant New Uses for Specific Chemical Substances § 721.3025 Fatty acids C12-18, C18 unsaturated, C12-18... chemical substance identified generically as fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters...

  19. STAR CLUSTERS IN M33: UPDATED UBVRI PHOTOMETRY, AGES, METALLICITIES, AND MASSES

    SciTech Connect

    Fan, Zhou; De Grijs, Richard E-mail: grijs@pku.edu.cn

    2014-04-01

    The photometric characterization of M33 star clusters is far from complete. In this paper, we present homogeneous UBVRI photometry of 708 star clusters and cluster candidates in M33 based on archival images from the Local Group Galaxies Survey, which covers 0.8 deg{sup 2} along the galaxy's major axis. Our photometry includes 387, 563, 616, 580, and 478 objects in the UBVRI bands, respectively, of which 276, 405, 430, 457, and 363 do not have previously published UBVRI photometry. Our photometry is consistent with previous measurements (where available) in all filters. We adopted Sloan Digital Sky Survey ugriz photometry for complementary purposes, as well as Two Micron All Sky Survey near-infrared JHK photometry where available. We fitted the spectral-energy distributions of 671 star clusters and candidates to derive their ages, metallicities, and masses based on the updated PARSEC simple stellar populations synthesis models. The results of our χ{sup 2} minimization routines show that only 205 of the 671 clusters (31%) are older than 2 Gyr, which represents a much smaller fraction of the cluster population than that in M31 (56%), suggesting that M33 is dominated by young star clusters (<1 Gyr). We investigate the mass distributions of the star clusters—both open and globular clusters—in M33, M31, the Milky Way, and the Large Magellanic Cloud. Their mean values are log (M {sub cl}/M {sub ☉}) = 4.25, 5.43, 2.72, and 4.18, respectively. The fraction of open to globular clusters is highest in the Milky Way and lowest in M31. Our comparisons of the cluster ages, masses, and metallicities show that our results are basically in agreement with previous studies (where objects in common are available); differences can be traced back to differences in the models adopted, the fitting methods used, and stochastic sampling effects.

  20. X-31 Wing Storage for Shipping

    NASA Technical Reports Server (NTRS)

    1995-01-01

    designers a better understanding of aerodynamics, effectiveness of flight controls and thrust vectoring, and airflow phenomena at high angles of attack. Stall is a condition of an airplane or an airfoil in which lift decreases and drag increases due to the separation of airflow. Thrust vectoring compensates for the loss of control through normal aerodynamic surfaces that occurs during a stall. Post-stall refers to flying beyond the normal stall angle of attack, which in the X-31 was at a 30-degree angle of attack. During Dryden flight testing, the X-31 aircraft established several milestones. On November 6, 1992, the X-31 achieved controlled flight at a 70-degree angle of attack. On April 29, 1993, the second X-31 successfully executed a rapid minimum-radius, 180-degree turn using a post-stall maneuver, flying well beyond the aerodynamic limits of any conventional aircraft. This revolutionary maneuver has been called the 'Herbst Maneuver' after Wolfgang Herbst, a German proponent of using post-stall flight in air-to-air combat. It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was

  1. 40 CFR 766.18 - Method sensitivity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level...

  2. 40 CFR 766.18 - Method sensitivity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level...

  3. 33 CFR 142.33 - Foot protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for foot injury to occur shall wear footwear meeting the specifications of ANSI Z41, except when... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Foot protection. 142.33 Section... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH Personal Protective Equipment § 142.33...

  4. 33 CFR 142.33 - Foot protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for foot injury to occur shall wear footwear meeting the specifications of ANSI Z41, except when... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Foot protection. 142.33 Section... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH Personal Protective Equipment § 142.33...

  5. 33 CFR 142.33 - Foot protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Foot protection. 142.33 Section... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH Personal Protective Equipment § 142.33 Foot... for foot injury to occur shall wear footwear meeting the specifications of ANSI Z41, except...

  6. 33 CFR 142.33 - Foot protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Foot protection. 142.33 Section... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH Personal Protective Equipment § 142.33 Foot... for foot injury to occur shall wear footwear meeting the specifications of ANSI Z41, except...

  7. 33 CFR 142.33 - Foot protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Foot protection. 142.33 Section... CONTINENTAL SHELF ACTIVITIES WORKPLACE SAFETY AND HEALTH Personal Protective Equipment § 142.33 Foot... for foot injury to occur shall wear footwear meeting the specifications of ANSI Z41, except...

  8. Elevated TGF-β1/IL-31 Pathway Is Associated with the Disease Severity of Hepatitis B Virus-Related Liver Cirrhosis.

    PubMed

    Ming, Desong; Yu, Xueping; Guo, Ruyi; Deng, Yong; Li, Julan; Lin, Chengzu; Su, Milong; Lin, Zhenzhong; Su, Zhijun

    2015-05-01

    The proinflammatory cytokines transforming growth factor beta 1 (TGF-β1) and interleukin (IL)-31 have been implicated in tissue injury. However, whether TGF-β1/IL-31 are stimulated and elevated in response to liver injury that leads to fibrogenesis in hepatitis B virus-related liver cirrhosis (HBV-LC) remains unclear. To investigate the association between TGF-β1/IL-31 and stages of chronic HBV infection, serum TGF-β1, IL-9, IL-10,IL-17, IL-22, IL-23, IL-31, IL-33, and IL-35 were determined among patients with chronic hepatitis B (CHB; n=19), HBV-LC (n=20), and a normal control population (NC; n=18). Disease severity in patients with HBV-LC was assessed using model for end-stage liver disease (MELD) scores. Serum TGF-β1 and IL-31 levels were strongly positively linked in all subjects, and both correlated positively with IL-22, IL-33, and IL-17. TGF-β1 and IL-31 levels in the blood were both significantly higher in CHB and HBV-LC patients than in NC subjects. Elevated serum TGF-β1 and IL-31 levels were positively associated with albumin, alpha-fetoprotein, creatinine, white blood cell count, and platelet levels. Serum TGF-β1 and IL-31 were markedly higher in HBV-LC patients who did not have esophageal varices, and IL-31 had the highest sensitivity and specificity (90.9% and 66.7%, respectively) for indicating the absence of this complication. In summary, TGF-β1 and IL-31 were linked to progression from CHB to LC, and correlated well with the severity of HBV-LC. These findings suggest possible roles of the TGF-β1/IL-31 pathway in the pathogenesis of liver fibrosis during chronic HBV infection.

  9. Expression, purification, and evaluation for anticancer activity of ribosomal protein L31 gene (RPL31) from the giant panda (Ailuropoda melanoleuca).

    PubMed

    Su, Xiu-Lan; Hou, Yi-Ling; Yan, Xiang-Hui; Ding, Xiang; Hou, Wan-Ru; Sun, Bing; Zhang, Si-Nan

    2012-09-01

    Ribosomal protein L31 gene is a component of the 60S large ribosomal subunit encoded by RPL31 gene, while ribosomal protein L31 (RPL31) is an important constituent of peptidyltransferase center. In our research, the cDNA and the genomic sequence of RPL31 were cloned successfully from the giant panda (Ailuropoda melanoleuca) using RT-PCR technology respectively, following sequencing and analyzing preliminarily. We constructed a recombinant expression vector contained RPL31 cDNA and over-expressed it in Escherichia coli using pET28a plasmids. The expression product was purified to obtain recombinant protein of RPL31 from the giant panda. Recombinant protein of RPL31 obtained from the experiment acted on human laryngeal carcinoma Hep-2 and human hepatoma HepG-2 cells for study of its anti-cancer activity by MTT [3-(4, 5-dimehyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide] method. Then observe these cells growth depressive effect. The result indicated that the cDNA fragment of the RPL31 cloned from the giant panda is 419 bp in size, containing an open reading frame of 378 bp, and deduced protein was composed of 125 amino acids with an estimated molecular weight of 14.46-kDa and PI of 11.21. The length of the genomic sequence is 8,091 bp, which was found to possess four exons and three introns. The RPL31 gene can be readily expressed in E.coli, expecting 18-kDa polypeptide that formed inclusion bodies. Recombinant protein RPL31 from the giant panda consists of 157 amino acids with an estimated molecular weight of 17.86 kDa and PI of 10.77. The outcomes showed that the cell growth inhibition rate in a time- and dose-dependent on recombinant protein RPL31. And also indicated that the effect at low concentrations was better than high concentrations on Hep-2 cells, and the concentration of 0.33 μg/mL had the best rate of growth inhibition, 44 %. Consequently, our study aimed at revealing the recombinant protein RPL31 anti-cancer function from the giant panda

  10. Prevention of Persistent Human Papillomavirus Infection by an HPV16/18 Vaccine: A Community-Based Randomized Clinical Trial in Guanacaste, Costa Rica

    PubMed Central

    Herrero, Rolando; Wacholder, Sholom; Rodríguez, Ana C.; Solomon, Diane; González, Paula; Kreimer, Aimee R.; Porras, Carolina; Schussler, John; Jiménez, Silvia; Sherman, Mark E.; Quint, Wim; Schiller, John T.; Lowy, Douglas R.; Schiffman, Mark; Hildesheim, Allan

    2011-01-01

    Target groups for human papillomavirus (HPV) vaccination are controversial. We evaluated vaccine efficacy (VE) against 1-year persistent infection, stratified by age and sexual behavior, among young women in Costa Rica. We randomized 7,466 healthy women 18 to 25 years of age to HPV16/18 or hepatitis A vaccine (follow-up, 50.4 months). According-to-protocol (ATP) cohorts included compliant HPV-negative women; intention-to-treat (ITT) included all randomized women. ATP VE was 90.9% (95% CI, 82.0–95.9) against HPV16/18 infections, 44.5% against HPV31/33/45 (95% CI, 17.5–63.1), and 12.4% (95% CI, −3.2 to 25.6) against any oncogenic infection. Overall ITT VE against HPV16/18 infections was 49.0%, but ATP and ITT VE almost reached 100% in year 4 of follow-up. ATP efficacy against HPV16/18 was similar by age, but ITT VE was greatest among youngest women (68.9% among those 18–19 years of age; 21.8% among those 24–25 years of age) and 79.8% among virgins. Among previously unexposed women, vaccination is highly efficacious against HPV16/18 and partially against HPV31/33/45. Vaccination is most effective in women and girls before they initiate sexual activity, with programmatic and individual decision implications. PMID:22586631

  11. 40 CFR 31.31 - Real property.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Real property. 31.31 Section 31.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Post-Award Requirements Changes, Property,...

  12. 14 CFR 77.31 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Scope. 77.31 Section 77.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE OBJECTS AFFECTING NAVIGABLE AIRSPACE (Eff. until 1-18-11) Aeronautical Studies of Effect of Proposed Construction...

  13. 33 CFR 175.201 - Ventilation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Ventilation. 175.201 Section 175... SAFETY EQUIPMENT REQUIREMENTS Ventilation § 175.201 Ventilation. No person may operate a boat built after July 31, 1980, that has a gasoline engine for electrical generation, mechanical power, or...

  14. 33 CFR 105.115 - Compliance dates.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Compliance dates. 105.115 Section... MARITIME SECURITY: FACILITIES General § 105.115 Compliance dates. (a) On or before December 31, 2003... required to obtain a TWIC under this part may enroll beginning after the date set by the Coast Guard in...

  15. [X-33 Research By NASA Centers

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Lockheed Martin Skunk Works has compiled an Annual Performance Report of the X-33/RLV Program. This report consists of individual reports from all industry team members, as well as NASA team centers. This portion of the report is comprised of overviews of each NASA Center's contribution to the program during the period 1 Apr. 1998 - 31 Mar. 1999.

  16. Effect of Ti content on the microstructure and mechanical behavior of (Fe36Ni18Mn33Al13)100–xTix high entropy alloys

    SciTech Connect

    Wang, Zhangwei; Wu, Margaret; Cai, Zhonghou; Chen, Si; Baker, Ian

    2016-06-13

    The microstructure and mechanical properties studies of a series of two-phase f.c.c./B2 (ordered b.c.c.) lamellar-structured, high entropy alloys (HEA) Fe36Ni18Mn33Al13Tix with x up to 6 at. % Ti have been investigated. X-ray microanalysis in a TEM showed that the Ti resided mostly in the B2 phase. The lamellar spacing decreased significantly with increasing Ti content from 1.56 μm for the undoped alloy to 155 nm with an addition of 4 at. % Ti, leading to a sharp increase in room-temperature yield strength,σy, from 270 MPa to 953 MPa, but with a concomitant decrease in ductility from 22% elongation to 2.3%. Annealing at 1173 K for 20 h greatly increased the lamellar spacing of Fe36Ni18Mn33Al13Ti4 to 577 nm, producing a corresponding decrease in σy to 511 MPa. The yield strengths of all the doped alloys decreased significantly when tensile tested at 973 K with a concomitant increase in ductility due to softening of the B2 phase. The fracture mode changed from cleavage at room temperature to a ductile dimple-type rupture at 973 K. Lastly, the results are discussed in terms of the Hall-Petch-type relationship.

  17. X-31 Loaded in C-5 Cargo Bay

    NASA Technical Reports Server (NTRS)

    1995-01-01

    was at a 30-degree angle of attack. During Dryden flight testing, the X-31 aircraft established several milestones. On November 6, 1992, the X-31 achieved controlled flight at a 70-degree angle of attack. On April 29, 1993, the second X-31 successfully executed a rapid minimum-radius, 180-degree turn using a post-stall maneuver, flying well beyond the aerodynamic limits of any conventional aircraft. This revolutionary maneuver has been called the 'Herbst Maneuver' after Wolfgang Herbst, a German proponent of using post-stall flight in air-to-air combat. It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was powered by a single General Electric P404-GE-400 turbofan engine that produced 16,000 pounds of thrust in afterburner.

  18. Five different profiles of dihydropyridines in blocking T-type Ca(2+) channel subtypes (Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I))) expressed in Xenopus oocytes.

    PubMed

    Furukawa, Taiji; Nukada, Toshihide; Namiki, Yoshiko; Miyashita, Yoriko; Hatsuno, Kento; Ueno, Yasunari; Yamakawa, Takeshi; Isshiki, Takaaki

    2009-06-24

    1,4-dihydropyridine (DHP) Ca(2+) antagonists have recently been shown to block T-type Ca(2+) channels, which may render favorable actions on cardiovascular systems. However, this evaluation remains to be done systematically for each T-type Ca(2+) channel subtype except for the Ca(v)3.1 (alpha(1G)) subtype. To address this issue at the molecular level, blocking effects of 14 kinds of DHPs (amlodipine, aranidipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nimodipine, nitrendipine), which are clinically used for treatments of hypertension, on 3 subtypes of T-type Ca(2+) channels [Ca(v)3.2 (alpha(1H)), Ca(v)3.3 (alpha(1I)), and Ca(v)3.1 (alpha(1G))] were investigated in the Xenopus oocyte expression system using the two-microelectrode voltage-clamp technique. These 3 kinds (alpha(1H), alpha(1I) and alpha(1G)) of T-type channels were blocked by amlodipine, manidipine and nicardipine. On the other hand, azelnidipine, barnidipine, benidipine and efonidipine significantly blocked alpha(1H) and alpha(1G), but not alpha(1I) channels, while nilvadipine and nimodipine apparently blocked alpha(1H) and alpha(1I), but not alpha(1G) channels. Moreover, aranidipine blocked only alpha(1H) channels. By contrast, cilnidipine, felodipine, nifedipine and nitrendipine had little effects on these subtypes of T-type channels. The result indicates that the blockade of T-type Ca(2+) channels by derivatives of DHP Ca(2+) antagonist was selective for the channel subtype. Therefore, these selectivities of DHPs in blocking T-type Ca(2+) channel subtypes would provide useful pharmacological and clinical information on the mode of action of the drugs including side-effects and adverse effects.

  19. 40 CFR 466.33 - New source performance standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false New source performance standards. 466.33 Section 466.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PORCELAIN ENAMELING POINT SOURCE CATEGORY Aluminum Basis...

  20. 40 CFR 466.33 - New source performance standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false New source performance standards. 466.33 Section 466.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) PORCELAIN ENAMELING POINT SOURCE CATEGORY Aluminum Basis...

  1. 40 CFR 710.33 - When to report.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false When to report. 710.33 Section 710.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT TSCA... period. The first reporting period is from August 25, 1986 to December 23, 1986. Any person described...

  2. 31. Historic American Buildings Survey, Photocopy of illustration in Pacific ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. Historic American Buildings Survey, Photocopy of illustration in Pacific Coast Architect, V. 33, No. 4 (April 1928) DETAIL, AUDITORIUM NORTH WALL. - Oriental Theatre, 828 Southeast Grand Avenue, Portland, Multnomah County, OR

  3. Nova in M31

    NASA Astrophysics Data System (ADS)

    Lang, F.; Lerchster, M.; Fliri, J.

    2006-05-01

    We report the discovery of a possible nova in M31 on a R band CCD image at JD 2453877.5 (2006, May 22.1 UT) with 18.7 mag (accuracy 0.1 mag). The image was obtained with the Wendelstein telescope (0.8 m, 1k x 1k CCD camera with 24mu sq. pixels). The position obtained for the nova candidate is RA(2000) = 00h 43m 11.81s, Dec(2000) = +41° 13' 44.7" with an accuracy of 0.1". At the position of the nova candidate no star brighter than 21.5 mag (1 sigma) was detected on 2006, May 12.2 UT on a Wendelstein R band image.

  4. X-31 Being Loaded into C-5 Cargo Plane

    NASA Technical Reports Server (NTRS)

    1995-01-01

    milestones. On November 6, 1992, the X-31 achieved controlled flight at a 70-degree angle of attack. On April 29, 1993, the second X-31 successfully executed a rapid minimum-radius, 180-degree turn using a post-stall maneuver, flying well beyond the aerodynamic limits of any conventional aircraft. This revolutionary maneuver has been called the 'Herbst Maneuver' after Wolfgang Herbst, a German proponent of using post-stall flight in air-to-air combat. It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was powered by a single General Electric P404-GE-400 turbofan engine that produced 16,000 pounds of thrust in afterburner.

  5. Oxalate-based soluble 2D magnets: the series [K(18-crown-6)]3[M(II)3(H2O)4{M(III)(ox)3}3] (M(III) = Cr, Fe; M(II) = Mn, Fe, Ni, Co, Cu; ox = C2O4(2-); 18-crown-6 = C12H24O6).

    PubMed

    Coronado, Eugenio; Galán-Mascarós, José R; Martí-Gastaldo, Carlos; Waerenborgh, João C; Gaczyński, Piotr

    2008-08-04

    The synthesis and magnetic properties of the oxalate-based molecular soluble magnets with general formula [K(18-crown-6)] 3[M (II) 3(H 2O) 4{M (III)(ox) 3} 3] (M (III) = Cr, Fe; M (II) = Mn, Fe, Ni, Co, Cu; ox = C 2O 4 (2-)) are here described. All the reported compounds are isostructural and built up by 2D bimetallic networks formed by alternating M (III) and M (II) ions connected through oxalate anions. Whereas the Cr (III)M (II) derivatives behave as ferromagnets with critical temperatures up to 8 K, the Fe (III)M (II) present ferri- or weak ferromagnetic ordering up to 26 K.

  6. Natural outcome of trisomy 13, trisomy 18, and triploidy after prenatal diagnosis.

    PubMed

    Lakovschek, Ioana Claudia; Streubel, Berthold; Ulm, Barbara

    2011-11-01

    Trisomy 13, trisomy 18, and triploidy belong to the chromosomal abnormalities which are compatible with life, but which are also associated with a high rate of spontaneous abortion, intrauterine death, and a short life span. This study was conducted to analyze natural outcome after prenatal diagnosis of these disorders. Between January 1, 1999 and December 31, 2009, we investigated all amniocenteses and chorionic villus biopsies carried out at our department. All cases with fetal diagnosis of triploidy, trisomy 13, and 18 were analyzed, with a focus on cases with natural outcome. Overall, 83 (78%) cases of pregnancy termination and 24 (22%) patients with natural outcome (NO) were identified. The NO group included 15 cases of trisomy 18, six cases of triploidy, and three cases of trisomy 13. No case of triploidy was born alive. The live birth rate was 13% for trisomy 18 and 33% for trisomy 13. The three live-born infants with trisomy 13 and 18 died early after a maximum of 87 hr postpartum. Our data are consistent with the literature concerning outcome of triploidy, with none or only a few live births. Analyzes of trisomy 13 and 18 indicate a very short postnatal life span. Different study designs and diverse treatment strategies greatly affect the fetal and neonatal outcome of fetuses with triploidy, trisomy 13, and 18. More studies analyzing natural outcome after prenatal diagnosis of these chromosomal abnormalities are needed. Non-termination of these pregnancies remains an option, and specialists advising parents need accurate data for counseling.

  7. 28 CFR 33.31 - Eligible purposes and programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... white-collar crime, organized crime, public corruption crimes, and fraud against the Government; (5... to undertake initiatives to prevent and control neighborhood crime; (2) Disrupting illicit commerce... assistance to jurors and witnesses, and assistance (other than compensation) to victims of crimes;...

  8. 28 CFR 33.31 - Eligible purposes and programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... white-collar crime, organized crime, public corruption crimes, and fraud against the Government; (5... to undertake initiatives to prevent and control neighborhood crime; (2) Disrupting illicit commerce... assistance to jurors and witnesses, and assistance (other than compensation) to victims of crimes;...

  9. 28 CFR 33.31 - Eligible purposes and programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... white-collar crime, organized crime, public corruption crimes, and fraud against the Government; (5... to undertake initiatives to prevent and control neighborhood crime; (2) Disrupting illicit commerce... assistance to jurors and witnesses, and assistance (other than compensation) to victims of crimes;...

  10. 28 CFR 33.31 - Eligible purposes and programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... white-collar crime, organized crime, public corruption crimes, and fraud against the Government; (5... to undertake initiatives to prevent and control neighborhood crime; (2) Disrupting illicit commerce... assistance to jurors and witnesses, and assistance (other than compensation) to victims of crimes;...

  11. 28 CFR 33.31 - Eligible purposes and programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... white-collar crime, organized crime, public corruption crimes, and fraud against the Government; (5... to undertake initiatives to prevent and control neighborhood crime; (2) Disrupting illicit commerce... assistance to jurors and witnesses, and assistance (other than compensation) to victims of crimes;...

  12. 33 CFR 385.31 - Adaptive management program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Engineers and the South Florida Water Management District shall, in consultation with the Department of the... implementation of the Plan. The Corps of Engineers and the South Florida Water Management District shall develop... the South Florida Water Management District for use in preparing the assessment report. The...

  13. 33 CFR 385.31 - Adaptive management program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Engineers and the South Florida Water Management District shall, in consultation with the Department of the... implementation of the Plan. The Corps of Engineers and the South Florida Water Management District shall develop... the South Florida Water Management District for use in preparing the assessment report. The...

  14. 33 CFR 385.31 - Adaptive management program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Engineers and the South Florida Water Management District shall, in consultation with the Department of the... implementation of the Plan. The Corps of Engineers and the South Florida Water Management District shall develop... the South Florida Water Management District for use in preparing the assessment report. The...

  15. 33 CFR 385.31 - Adaptive management program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Engineers and the South Florida Water Management District shall, in consultation with the Department of the... implementation of the Plan. The Corps of Engineers and the South Florida Water Management District shall develop... the South Florida Water Management District for use in preparing the assessment report. The...

  16. 31 CFR 33.120 - Monitoring and compliance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... must comply with all applicable Federal laws, regulations, interpretive policy statements and interpretive guidance unless expressly waived. A State must, within the timeframes specified in law, regulation, policy, or guidance, come into compliance with any changes in Federal law, regulation, or...

  17. 31 CFR 33.100 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Patient Protection and Affordable Care Act (Affordable Care Act), Public Law 111-148, relating to Waivers... submission of an application that ensures the disclosure of all of the following: (i) The provisions of law... implementation of a waiver. (5) A process for the periodic evaluation by the Secretary of programs under...

  18. 33 CFR 385.31 - Adaptive management program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Engineers and the South Florida Water Management District shall, in consultation with the Department of the... implementation of the Plan. The Corps of Engineers and the South Florida Water Management District shall develop... the South Florida Water Management District for use in preparing the assessment report. The...

  19. 37 CFR 5.31-5.33 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... atomic energy 1.14(d) Reservation for future application not permitted 1.79 Secrecy order 5.1-5.5 Tables... recording 3.21-3.41 What will be accepted for recording 3.11 Atomic energy applications reported to... connection with old structure 1.83(b) Incorporation by reference to prior application 1.57 In...

  20. 37 CFR 5.31-5.33 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... applications) Relating to atomic energy 1.14(d) Reservation for future application not permitted 1.79 Secrecy... Atomic energy applications reported to Department of Energy 1.14 Attorneys and agents: Acting in a...) If of an improvement, must show connection with old structure 1.83(b) In international applications...

  1. 37 CFR 5.31-5.33 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Publication. (See Publication of applications) Relating to atomic energy 1.14(d) Reservation for future... 3.11 Atomic energy applications reported to Department of Energy 1.14 Attorneys and agents: Acting...) If of an improvement, must show connection with old structure 1.83(b) In international applications...

  2. 37 CFR 5.31-5.33 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... applications) Relating to atomic energy 1.14(d) Reservation for future application not permitted 1.79 Secrecy... Atomic energy applications reported to Department of Energy 1.14 Attorneys and agents: Acting in a...) If of an improvement, must show connection with old structure 1.83(b) In international applications...

  3. 37 CFR 5.31-5.33 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... applications) Relating to atomic energy 1.14(d) Reservation for future application not permitted 1.79 Secrecy... Atomic energy applications reported to Department of Energy 1.14 Attorneys and agents: Acting in a...) If of an improvement, must show connection with old structure 1.83(b) In international applications...

  4. 33 CFR 125.31 - Approval of applicant by Commandant.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... satisfied that the character and habits of life of the applicant are not such as to warrant the belief that... habits of life of the applicant are such as to warrant the belief that his presence on...

  5. 18 CFR 33.1 - Applicability, definitions, and blanket authorizations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 203 of the Federal Power Act (16 U.S.C. 824b). (1) Existing generation facility means a generation... electric power cooperative. (5) For purposes of this part, the term captive customers means any wholesale... an electric utility is granted a blanket authorization under section 203(a)(2) of the Federal...

  6. 18 CFR 33.1 - Applicability, definitions, and blanket authorizations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 203 of the Federal Power Act (16 U.S.C. 824b). (1) Existing generation facility means a generation... electric power cooperative. (5) For purposes of this part, the term captive customers means any wholesale... an electric utility is granted a blanket authorization under section 203(a)(2) of the Federal...

  7. 18 CFR 415.33 - Uses by special permit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... transient enterprises. (3) Drive-in theaters, signs and billboards. (4) Extraction of sand, gravel and other... flood proofed to the Flood Protection Elevation. Accessory land uses, such as yards, railroad tracks and...) Utilities, railroad tracks, streets and bridges. Public utility facilities, roads, railroad tracks...

  8. 18 CFR 4.33 - Limitations on submitting applications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., EXEMPTIONS, AND DETERMINATION OF PROJECT COSTS Application for Preliminary Permit, License or Exemption... preliminary permit for project works that: (1) Would develop, conserve, and utilize, in whole or in part, the... an unexpired preliminary permit. (2) Would interfere with a licensed project in a manner that,...

  9. 18 CFR 4.33 - Limitations on submitting applications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., EXEMPTIONS, AND DETERMINATION OF PROJECT COSTS Application for Preliminary Permit, License or Exemption... preliminary permit for project works that: (1) Would develop, conserve, and utilize, in whole or in part, the... an unexpired preliminary permit. (2) Would interfere with a licensed project in a manner that,...

  10. 18 CFR 415.33 - Uses by special permit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... hereinafter provided: (1) Uses or structures accessory to open space use. (2) Circuses, carnivals and similar transient enterprises. (3) Drive-in theaters, signs and billboards. (4) Extraction of sand, gravel and other non-toxic materials. (5) Marinas, boat liveries, docks, piers, wharves and water control...

  11. 18 CFR 415.33 - Uses by special permit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... hereinafter provided: (1) Uses or structures accessory to open space use. (2) Circuses, carnivals and similar... non-toxic materials. (5) Marinas, boat liveries, docks, piers, wharves and water control structures. (6) Fish hatcheries. (7) Railroads, streets, bridges, utility transmission lines and pipelines....

  12. 18 CFR 415.33 - Uses by special permit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... hereinafter provided: (1) Uses or structures accessory to open space use. (2) Circuses, carnivals and similar... non-toxic materials. (5) Marinas, boat liveries, docks, piers, wharves and water control structures. (6) Fish hatcheries. (7) Railroads, streets, bridges, utility transmission lines and pipelines....

  13. 18 CFR 415.33 - Uses by special permit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... hereinafter provided: (1) Uses or structures accessory to open space use. (2) Circuses, carnivals and similar... non-toxic materials. (5) Marinas, boat liveries, docks, piers, wharves and water control structures. (6) Fish hatcheries. (7) Railroads, streets, bridges, utility transmission lines and pipelines....

  14. 33 CFR 263.18 - Program completion-time objectives.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... submission of funding request or negative report to OCE 2 1 2 (b) Completion of feasibility study by... these objectives is encouraged for specific studies and projects when appropriate. However,...

  15. 18 CFR 157.33 - Requirement for open season.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... agreements. All pre-subscription agreements shall be made public by posting on Internet websites and press releases within ten days of their execution. In the event there is more than one such agreement,...

  16. X-31 Unloading Returning from Paris Air Show

    NASA Technical Reports Server (NTRS)

    1995-01-01

    controlled flight at a 70-degree angle of attack. On April 29, 1993, the second X-31 successfully executed a rapid minimum-radius, 180-degree turn using a post-stall maneuver, flying well beyond the aerodynamic limits of any conventional aircraft. This revolutionary maneuver has been called the 'Herbst Maneuver' after Wolfgang Herbst, a German proponent of using post-stall flight in air-to-air combat. It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was powered by a single General Electric P404-GE-400 turbofan engine that produced 16,000 pounds of thrust in afterburner.

  17. 40 CFR 721.10297 - Tin, C16-18 and C18-unsatd. fatty acids castor-oil fatty acids complexes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Tin, C16-18 and C18-unsatd. fatty... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.10297 Tin, C16-18 and C18-unsatd... to reporting. (1) The chemical substance identified as tin, C16-18 and C18-unsatd. fatty acids...

  18. CONTROL ROOM ON MARCH 31, 1952, AS THE MTR GOES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTROL ROOM ON MARCH 31, 1952, AS THE MTR GOES CRITICAL FOR THE FIRST TIME. COMPARE CEILING FIXTURES IN THIS PHOTO AND PHOTO ID-33-G-212 FOR COMMON PERSPECTIVE. INL NEGATIVE NO. 4517. Unknown Photographer, 3/31/1952 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  19. X-31 impact site

    NASA Technical Reports Server (NTRS)

    1995-01-01

    -vectoring and high angle-of-attack (AOA) flight control mode turned off. Lang noticed erroneous airspeed readings (207 knots indicated airspeed at 20 degrees AOA). About a minute later, while executing the pre-landing checklist, the X-31 began a rapidly increasing series of pitch oscillations, ending up at about 20 degrees past vertical. This was followed by a sharp roll. Lang ejected at 18,050 feet, and parachuted to safety with some injuries. The X-31 crashed in a sparsely-populated area a mile and a half north of the base boundary. Investigators later determined that ice in the air data probe caused the erroneous readings that led to the accident.

  20. 34 CFR 33.43 - Collection of civil penalties and assessments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Collection of civil penalties and assessments. 33.43 Section 33.43 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.43 Collection of civil penalties and assessments. Section 3806 and 3808(b) of title 31,...

  1. X-31 Enhanced Fighter Maneuverability Aircraft in Flight

    NASA Technical Reports Server (NTRS)

    1992-01-01

    . It is also called a 'J Turn' when flown to an arbitrary heading change. The aircraft was flown in tactical maneuvers against an F/A-18 and other tactical aircraft as part of the test flight program. During November and December 1993, the X-31 reached a supersonic speed of Mach 1.28. In 1994, the X-31 program installed software to demonstrate quasi-tailless operation. The X-31 flight test program was conducted by an international test organization (ITO) managed by the Advanced Research Projects Office (ARPA), known as the Defense Advanced Research Projects Office (DARPA) before March 1993. The ITO included the U.S. Navy and U.S. Air Force, Rockwell Aerospace, the Federal Republic of Germany, Daimler-Benz (formerly Messerschmitt-Bolkow-Blohm and Deutsche Aerospace), and NASA. Gary Trippensee was the ITO director and NASA Project Manager. Pilots came from participating organizations. The X-31 was 43.33 feet long with a wingspan of 23.83 feet. It was powered by a single General Electric P404-GE-400 turbofan engine that produced 16,000 pounds of thrust in afterburner.

  2. 33 CFR 103.515 - Exercises.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Exercises. 103.515 Section 103... MARITIME SECURITY: AREA MARITIME SECURITY Area Maritime Security (AMS) Plan § 103.515 Exercises. (a) The... exercise at least once each calendar year, with no more than 18 months between exercises, to test...

  3. 33 CFR 103.515 - Exercises.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Exercises. 103.515 Section 103... MARITIME SECURITY: AREA MARITIME SECURITY Area Maritime Security (AMS) Plan § 103.515 Exercises. (a) The... exercise at least once each calendar year, with no more than 18 months between exercises, to test...

  4. 33 CFR 103.515 - Exercises.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Exercises. 103.515 Section 103... MARITIME SECURITY: AREA MARITIME SECURITY Area Maritime Security (AMS) Plan § 103.515 Exercises. (a) The... exercise at least once each calendar year, with no more than 18 months between exercises, to test...

  5. 33 CFR 103.515 - Exercises.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Exercises. 103.515 Section 103... MARITIME SECURITY: AREA MARITIME SECURITY Area Maritime Security (AMS) Plan § 103.515 Exercises. (a) The... exercise at least once each calendar year, with no more than 18 months between exercises, to test...

  6. 33 CFR 103.515 - Exercises.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Exercises. 103.515 Section 103... MARITIME SECURITY: AREA MARITIME SECURITY Area Maritime Security (AMS) Plan § 103.515 Exercises. (a) The... exercise at least once each calendar year, with no more than 18 months between exercises, to test...

  7. 40 CFR 180.33 - Fees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Procedural Regulations § 180.33 Fees. (a) Each petition... tolerance already established for the same pesticide chemical, or for the establishment of a tolerance on... the same pesticide chemical, shall be accompanied by a fee of $18,500 plus $1,225 for each...

  8. 18 CFR 3a.31 - Classification markings and special notations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Confidential will be stamped in red ink, printed, or written in letters considerably larger than those used in.... Letters of transmittal, endorsements, routing slips, or any other papers of any size which conceal...

  9. 18 CFR 3a.31 - Classification markings and special notations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Confidential will be stamped in red ink, printed, or written in letters considerably larger than those used in.... Letters of transmittal, endorsements, routing slips, or any other papers of any size which conceal...

  10. 38 CFR 18b.31 - Answer to notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... detail each allegation of the notice, unless the respondent party is without knowledge, in which case the answer should so state, and the statement will be deemed a denial. Allegations of fact in the notice...

  11. 31 CFR 321.18 - Determination of loss.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., has determined that such loss resulted from no fault or negligence on the part of such agent; or (c... designee, has been unable to make an affirmative finding that such loss resulted from no fault...

  12. 31 CFR 321.18 - Determination of loss.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... his designee, has determined that such loss resulted from no fault or negligence on the part of such... fault or negligence on the part of such agent, reimbursement must be made promptly, except where...

  13. 31 CFR 321.18 - Determination of loss.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., has determined that such loss resulted from no fault or negligence on the part of such agent; or (c... designee, has been unable to make an affirmative finding that such loss resulted from no fault...

  14. 31 CFR 321.18 - Determination of loss.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Treasury, or his designee, has determined that such loss resulted from no fault or negligence on the part... from no fault or negligence on the part of such agent, reimbursement must be made promptly,...

  15. 18 CFR 806.31 - Term of approvals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... approval issued under this part shall be no longer than 15 years or the anticipated life of the project... extension, for a period not to exceed two years, only upon a determination that the delay is due to... extensions, including modification of any terms of approval that the Commission may deem appropriate. (c)...

  16. 18 CFR 806.31 - Term of approvals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... approval issued under this part shall be no longer than 15 years or the anticipated life of the project... extension, for a period not to exceed two years, only upon a determination that the delay is due to... extensions, including modification of any terms of approval that the Commission may deem appropriate. (c)...

  17. 18 CFR 806.31 - Term of approvals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... approval issued under this part shall be no longer than 15 years or the anticipated life of the project... extension, for a period not to exceed two years, only upon a determination that the delay is due to... extensions, including modification of any terms of approval that the Commission may deem appropriate. (c)...

  18. 18 CFR 430.31 - Sanctions: Civil and criminal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Commission may, in his discretion, request the appropriate law enforcement officers of the... Compact and the laws of the Commonwealth, and for recovery of the fines fixed by section 14.17 of the Compact, in the name and on behalf of the Commission. The Commonwealth of Pennsylvania and its...

  19. 18 CFR 430.31 - Sanctions: Civil and criminal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the Commission may, in his discretion, request the appropriate law enforcement officers of the... Compact and the laws of the Commonwealth, and for recovery of the fines fixed by section 14.17 of the Compact, in the name and on behalf of the Commission. The Commonwealth of Pennsylvania and its...

  20. LANL JOWOG 31 2012 Forecast

    SciTech Connect

    Vidlak, Anton J. II

    2012-08-08

    Joint Working Group (JOWOG) 31, Nuclear Weapons Engineering, has a particularly broad scope of activities within its charter which emphasizes systems engineering. JOWOG 31 brings together experts from AWE and the national laboratories to address engineering issues associated with warhead design and certification. Some of the key areas of interaction, as addressed by the HOCWOGs are: (1) Engineering Analysis, (2) Hydrodynamic Testing, (3) Environmental Testing, and (4) Model Based Integrated Toolkit (MBIT). Gas Transfer Systems and Condition Monitoring interaction has been moved back to JOWOG 31. The regularly scheduled JOWOG 31 activities are the General Sessions, Executive Sessions, Focused Exchanges and HOCWOGs. General Sessions are scheduled every 12-18 months and are supported by the four design laboratories (AWE, LANL, LLNL, and SNL). Beneficial in educating the next generation of weapons engineers and establishing contacts between AWE and the US laboratory personnel. General Sessions are based on a blend of presentations and workshops centered on various themed subjects directly related to Stockpile Stewardship. HOCWOG meetings are more narrowly focused than the General Sessions. They feature presentations by experts in the field with a greater emphasis on round table discussions. Typically about 20 people attend. Focused exchanges are generally the result of interactions within JOWOG general sessions or HOCWOG meetings. They generally span a very specific topic of current interest within the US and UK.

  1. 18S rRNA Gene Variation among Common Airborne Fungi, and Development of Specific Oligonucleotide Probes for the Detection of Fungal Isolates

    PubMed Central

    Wu, Zhihong; Tsumura, Yoshihiko; Blomquist, Göran; Wang, Xiao-Ru

    2003-01-01

    In this study, we sequenced 18S rRNA genes (rDNA) from 49 fungal strains representing 31 species from 15 genera. Most of these species are common airborne fungi and pathogens that may cause various public health concerns. Sequence analysis revealed distinct divergence between Zygomycota and Ascomycota. Within Ascomycota, several strongly supported clades were identified that facilitate the taxonomic placement of several little-studied fungi. Wallemia appeared as the group most diverged from all the other Ascomycota species. Based on the 18S rDNA sequence variation, 108 oligonucleotide probes were designed for each genus and species included in this study. After homology searches and DNA hybridization evaluations, 33 probes were verified as genus or species specific. The optimal hybridization temperatures to achieve the best specificity for these 33 probes were determined. These new probes can contribute to the molecular diagnostic research for environmental monitoring. PMID:12957927

  2. A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors.

    PubMed

    Wick, Darin A; Webb, John R

    2011-10-13

    Persistent infection by high risk genotypes of human papillomavirus (HPV) is the cause of cervical cancer, which remains one of the most common cancers among women worldwide. In addition, there is a growing appreciation that high risk HPVs are associated with a number of other cancers including anogenital cancers as well as a subset of head and neck cancers. Recently, prophylactic HPV vaccines targeting the two most prevalent high risk HPVs (HPV16 and HPV18) have been deployed in large-scale vaccination campaigns. However, the extent to which these prophylactic vaccines confer protection against other high risk HPV genotypes is largely unknown and prophylactic vaccines have been shown to be ineffective against pre-existing infection. Thus there continues to be an urgent need for effective therapeutic vaccines against HPV. The E7 protein of HPV16 has been widely studied as a target for therapeutic vaccines in HPV-associated cancer settings because HPV16 is the most prevalent of the high risk HPV genotypes. However, HPV16 accounts for only about 50% of cervical cancers and there are at least 15 other high risk HPVs that are known to be oncogenic. We have developed a novel, broad-spectrum, therapeutic vaccine (Pentarix) directed at the E7 proteins from five of the most prevalent high-risk genotypes of HPV worldwide (HPV16, 18, 31, 45 and 52) that together account for more than 80% of all HPV-associated cancers. Pentarix is a recombinant protein-based vaccine that elicits strong, multi-genotype specific CD8 T cell immunity when administered to mice in combination with adjuvants comprised of agonists of the TLR3 or TLR9 family of innate immune receptors. Furthermore, large, established E7-expressing TC-1 tumors undergo rapid and complete regression after therapeutic vaccination of mice with Pentarix. Together, these data suggest that Pentarix may be of clinical value for patients with E7-positive, HPV-associated precancerous lesions or malignant disease.

  3. 14 CFR 77.33 - Initiation of studies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Initiation of studies. 77.33 Section 77.33 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE OBJECTS AFFECTING NAVIGABLE AIRSPACE (Eff. until 1-18-11) Aeronautical Studies of Effect of...

  4. Douglas YO-31A

    NASA Technical Reports Server (NTRS)

    1932-01-01

    Douglas YO-31A: The mockup model of the gull-winged Douglas YO-31A observation plane was tested in Langley's 30 x 60 Full Scale Tunnel during 1932. As part of the drag clean-up that was under examination of the YO-31, the model aircraft was 'flown' in the tunnel with and without the wheel fairings.

  5. METAL-RICH PLANETARY NEBULAE IN THE OUTER REACHES OF M31

    SciTech Connect

    Balick, B.; Kwitter, K. B.; Corradi, R. L. M.; Henry, R. B. C. E-mail: kkwitter@williams.edu E-mail: henry@ou.edu

    2013-09-01

    Spectroscopic data of two relatively [O III]-luminous planetary nebulae (PNe) have been obtained with the 10.4 m Gran Telescopio Canarias. M174 and M2496 are each {approx}1 Degree-Sign from the center of M31 along opposite sides of its minor axis. The ensemble of these 2 distant PNe plus 16 similarly luminous outer-disk PNe published previously by Kwitter et al. forms a homogeneous group in luminosity, metal content, progenitor mass, age, and kinematics. The main factual findings of our work are (1) O/H (and other low-mass {alpha} elements and their ratios to O) is uniformly solar-like in all 18 PNe ((12 + log(O/H)) = 8.62 {+-} 0.14); (2) the general sky distribution and kinematics of the ensemble much more closely resemble the rotation pattern of the classical disk of M31 than its halo or bulge; (3) the O/H gradient is surprisingly flat beyond R{sub g} {approx} 20 kpc. The PNe are too metal-rich to be bona fide members of M31's disk or halo, and (4) the abundance patterns of the sample are distinct from those in the spiral galaxies M33, M81, and NGC 300. Using standard PN age diagnostic methods, we suggest that all of the PNe formed {approx}2 Gyr ago in a starburst of metal-rich interstellar medium that followed an M31-M33 encounter about 3 Gyr ago. We review supporting evidence from stellar studies. Other more prosaic explanations, such as dwarf galaxy assimilation, are unlikely.

  6. 31 CFR Appendix to Part 341 - Tables of Redemption Values

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 56.57 113.14 565.70 1,131.41 3 to 31/2 57.98 115.97 579.85 1,159.69 31/2 to 4 59.43 118.87 594.34 1.... The redemption values have been determined to provide an investment yield of 3.75 percent 1 per annum...,057.31 2 to 21/2 53.86 107.71 538.57 1,077.14 21/2 to 3 54.87 109.73 548.67 1,097.33 3 to 31/2...

  7. 31 CFR Appendix to Part 341 - Tables of Redemption Values

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 56.57 113.14 565.70 1,131.41 3 to 31/2 57.98 115.97 579.85 1,159.69 31/2 to 4 59.43 118.87 594.34 1.... The redemption values have been determined to provide an investment yield of 3.75 percent 1 per annum...,057.31 2 to 21/2 53.86 107.71 538.57 1,077.14 21/2 to 3 54.87 109.73 548.67 1,097.33 3 to 31/2...

  8. 32 CFR 33.26 - Non-Federal audit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Amendments of 1996 (31 U.S.C. 7501-7507) and revised OMB Circular A-133, “Audits of States, Local Governments... 32 National Defense 1 2010-07-01 2010-07-01 false Non-Federal audit. 33.26 Section 33.26 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT...

  9. Intrauterine death in singleton pregnancies with trisomy 21, 18, 13 and monosomy X.

    PubMed

    Goulart, Vanessa Vigna; Liao, Adolfo Wenjaw; Carvalho, Mario Henrique Burlacchini de; Brizot, Maria de Lourdes; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo

    2016-04-01

    A retrospective study from November 2004 to May 2012, conducted at the Obstetric Clinic of Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP), which included 92 singleton pregnancies with prenatal diagnosis of trisomy of chromosome 21 (T21), 18, 13 (T13/18) and monosomy X (45X), with diagnosis performed until the 26th week of pregnancy. The aim of the study was to describe the frequency and to investigate predictors of spontaneous fetal death (FD). Diagnosis (T21, n=36; T13/18, n=25; 45X, n=31) was made at a mean gestational age of 18.3±3.7 weeks, through chorionic villus biopsy (n=22,24%), amniocentesis (n=66, 72%) and cordocentesis (n=4, 4%). Major malformations were present in 45 (49%); with hydrops in 32 (35%) fetuses, more frequently in 45X [n=24/31, 77% vs. T21 (n=6/36, 17%) and T13/18 (n=2/25, 8%), p<0.001]. Specialized fetal echocardiography was performed in 60% (55/92). Of these, 60% (33/55) showed changes in heart morphology and/or function. Fetuses with T13/18 had a higher incidence of cardiac anomalies [60 vs. 25% (T21) and 29% (45X), p= 0.01]. FD occurred in 55 (60%) gestations, being more frequent in 45X [n=26/31, 84% vs. T21 (n=13/36, 36%) and T13/18 (n=16/25, 64%), p<0.01]. Stepwise analysis showed a correlation between hydrops and death in fetuses with T21 (LR= 4.29; 95CI=1.9-8.0, p<0.0001). In fetuses with 45X, the presence of echocardiographic abnormalities was associated with lower risk of FD (LR= 0.56; 95CI=0.27- 0.85, p=0.005). No predictive factors were identified in the T13/18 group. Intra- uterine lethality of aneuploid fetuses is high. Occurrence of hydrops increases risk of FD in pregnancies with T21. In pregnancies with 45X, the occurrence of echocardiographic changes reduces this risk.

  10. X-33 RCS model

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Part of the high pressure nitrogen system used for the 1% scale X-33 reaction control system model. Installed in the Unitary Plan Wind Tunnel for supersonic testing. In building 1251, test section #2.

  11. X-33 RCS model

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Model support system and instumentation cabling of the 1% scale X-33 reaction control system model. Installed in the Unitary Plan Wind Tunnel for supersonic testing. In building 1251, test section #2.

  12. X-33 Development History

    NASA Technical Reports Server (NTRS)

    Butrica, Andrew J.

    1997-01-01

    The problem of dealing with various types of proprietary documents, whether from the Lockheed Martin, the Skunk Works, McDonnell Douglas, Rockwell, and other corporations extant or extinct, remains unresolved. The computerized archive finding aid has over 100 records at present. These records consist of X-33 photographs, press releases, media clippings, and the small number of X-33 project records collected to date.

  13. 31 CFR 103.90 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... definitions apply: (a) Money laundering means an activity criminalized by 18 U.S.C. 1956 or 1957, or an... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Definitions. 103.90 Section 103.90 Money and Finance: Treasury Regulations Relating to Money and Finance FINANCIAL RECORDKEEPING...

  14. 48 CFR 31.205-31 - Plant reconversion costs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Plant reconversion costs. 31.205-31 Section 31.205-31 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Organizations 31.205-31 Plant reconversion costs. Plant reconversion costs are those incurred in restoring...

  15. 48 CFR 31.205-31 - Plant reconversion costs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Plant reconversion costs. 31.205-31 Section 31.205-31 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Organizations 31.205-31 Plant reconversion costs. Plant reconversion costs are those incurred in restoring...

  16. The X-33 Program Update

    NASA Technical Reports Server (NTRS)

    Dill, Charlie

    2000-01-01

    This viewgraph presentation gives an overview of the X-33 program update, including details on program objectives and plans, the X-33 configuration, technologies used, and X-33 assembly and test status.

  17. 49 CFR 1242.32 - Joint facility rents-debit and credit and joint facility-debit and credit (accounts 33-17-00, 33...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Joint facility rents-debit and credit and joint facility-debit and credit (accounts 33-17-00, 33-18-00, 33-19-00, 34-17-00, 34-18-00, 34-19-00, 37-17-00... PASSENGER SERVICE FOR RAILROADS 1 Operating Expenses-Way and Structures § 1242.32 Joint facility...

  18. 30 CFR 18.34 - Motors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... at the flame-arresting portion might require such machining. (4) Ball and roller bearings and oil... clearance(s) shall conform to the requirements of § 18.31. (6) Oil seals shall be removed from motors prior to submission for explosion tests. Note: Oil seals will be removed from motors prior to...

  19. Synthesis, crystal structures and ionic conductivities of Bi{sub 14}P{sub 4}O{sub 31} and Bi{sub 50}V{sub 4}O{sub 85}. Two members of the series Bi{sub 18-4m}M{sub 4m}O{sub 27+4m} (M=P, V) related to the fluorite-type structure

    SciTech Connect

    Mauvy, F.; Launay, J.C.; Darriet, J. . E-mail: darriet@icmcb-bordeaux.cnrs.fr

    2005-06-15

    The two hitherto unknown compounds Bi{sub 14}P{sub 4}O{sub 31} and Bi{sub 50}V{sub 4}O{sub 85} were prepared by the direct solid-state reaction of Bi{sub 2}O{sub 3} and (NH{sub 4})H{sub 2}PO{sub 4} or V{sub 2}O{sub 5}, respectively. Bi{sub 14}P{sub 4}O{sub 31} crystallizes in a C-centred monoclinic symmetry (C2/c space group) with the unit-cell parameters: a=19.2745(2)A, b=11.3698(1)A, c=52.4082(2)A and {beta}=93.63(1){sup o} (Z=16). The symmetry of Bi{sub 50}V{sub 4}O{sub 85} is also monoclinic (I2/m space group) with lattice parameters of a=11.8123(3)A, b=11.7425(2)A, c=16.5396(2)A and {beta}=90.14(1){sup o} (Z=2). Both structures correspond to a fluorite-type superstructure where the Bi and P or V atoms are ordered in the framework. An idealized structural model is proposed where the structures result of the stacking of mixed atomic layers of composition [Bi{sub 14}M{sub 4}O{sub 31}] and [Bi{sub 18}O{sub 27}] respectively. This new family can be formulated Bi{sub 18-4m}M{sub 4m}O{sub 27+4m} with M=P, V and where the parameter m (0=31}] layers to the total number of layers in the sequence. Bi{sub 14}P{sub 4}O{sub 31} corresponds to m=1 when Bi{sub 50}V{sub 8}O{sub 85} corresponds to m=1/3. In this last case, the structural sequence is simply one [Bi{sub 14}V{sub 4}O{sub 31}] layer to two [Bi{sub 18}O{sub 27}] layers. As predicted by the proposed structural building principle, Bi{sub 14}P{sub 4}O{sub 31} is not a good ionic conductor. The conductivity at 650 deg. C is 4 orders of magnitude lower from those found in Bi{sub 46}M{sub 8}O{sub 89} (M=P, V) (m=2/3) and Bi{sub 50}V{sub 4}O{sub 85} (m=1/3)

  20. 31 CFR 357.31 - Certifying individuals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... BONDS, NOTES AND BILLS HELD IN TREASURY/RESERVE AUTOMATED DEBT ENTRY SYSTEM (TRADES) AND LEGACY TREASURY DIRECT Legacy Treasury Direct Book-Entry Securities System (Legacy Treasury Direct) § 357.31 Certifying... assignments of securities; or (iii) To certify assignments of securities. (2) Officers and...

  1. 31 CFR 31.201 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... committees of Congress, the purchase of which is necessary to promote financial market stability. ... Conflicts of Interest § 31.201 Definitions. As used in this part: Arrangement means a contract or financial... program, or has a financial interest that could be affected by its performance of the...

  2. 31 CFR 31.201 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Conflicts of Interest § 31.201 Definitions. As used in this part: Arrangement means a contract or financial... program, or has a financial interest that could be affected by its performance of the arrangement. Personal conflict of interest means a personal, business, or financial interest of an individual, his...

  3. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the Manatee River enclosed by a line beginning at latitude 27°3118.6″ N. longitude 82°36′49.2″ W.; thence westerly to latitude 27°31′21″ N., longitude 82°37′7.2″ W.; thence northwesterly to latitude 27°31′22.2″ N., longitude 82°37′8.4″ W.; thence northeasterly to latitude 27°31′25.8″ N., longitude...

  4. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of the Manatee River enclosed by a line beginning at latitude 27°3118.6″ N. longitude 82°36′49.2″ W.; thence westerly to latitude 27°31′21″ N., longitude 82°37′7.2″ W.; thence northwesterly to latitude 27°31′22.2″ N., longitude 82°37′8.4″ W.; thence northeasterly to latitude 27°31′25.8″ N., longitude...

  5. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of the Manatee River enclosed by a line beginning at latitude 27°3118.6″ N. longitude 82°36′49.2″ W.; thence westerly to latitude 27°31′21″ N., longitude 82°37′7.2″ W.; thence northwesterly to latitude 27°31′22.2″ N., longitude 82°37′8.4″ W.; thence northeasterly to latitude 27°31′25.8″ N., longitude...

  6. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of the Manatee River enclosed by a line beginning at latitude 27°3118.6″ N. longitude 82°36′49.2″ W.; thence westerly to latitude 27°31′21″ N., longitude 82°37′7.2″ W.; thence northwesterly to latitude 27°31′22.2″ N., longitude 82°37′8.4″ W.; thence northeasterly to latitude 27°31′25.8″ N., longitude...

  7. 33 CFR 110.74a - Manatee River, Bradenton, Fla.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of the Manatee River enclosed by a line beginning at latitude 27°3118.6″ N. longitude 82°36′49.2″ W.; thence westerly to latitude 27°31′21″ N., longitude 82°37′7.2″ W.; thence northwesterly to latitude 27°31′22.2″ N., longitude 82°37′8.4″ W.; thence northeasterly to latitude 27°31′25.8″ N., longitude...

  8. 29. August, 1970 WEST ELEVATIONS OF 14, 16, 18, 20 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. August, 1970 WEST ELEVATIONS OF 14, 16, 18, 20 UNION STREET (NOT IN STUDY AREA) - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  9. 14. September, 1968 GATE BETWEEN SALLY BEARD GARDNER HOUSE, 18 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. September, 1968 GATE BETWEEN SALLY BEARD GARDNER HOUSE, 18 ORANGE STREET AND LUCINDA MOOERS HOUSE, 20 ORANGE STREET - Orange & Union Streets Neighborhood Study, 8-31 Orange Street, 9-21 Union Street & Stone Alley, Nantucket, Nantucket County, MA

  10. Clustering of local group distances: Publication bias or correlated measurements? II. M31 and beyond

    SciTech Connect

    De Grijs, Richard; Bono, Giuseppe

    2014-07-01

    The accuracy of extragalactic distance measurements ultimately depends on robust, high-precision determinations of the distances to the galaxies in the local volume. Following our detailed study addressing possible publication bias in the published distance determinations to the Large Magellanic Cloud (LMC), here we extend our distance range of interest to include published distance moduli to M31 and M33, as well as to a number of their well-known dwarf galaxy companions. We aim at reaching consensus on the best, most homogeneous, and internally most consistent set of Local Group distance moduli to adopt for future, more general use based on the largest set of distance determinations to individual Local Group galaxies available to date. Based on a careful, statistically weighted combination of the main stellar population tracers (Cepheids, RR Lyrae variables, and the magnitude of the tip of the red-giant branch), we derive a recommended distance modulus to M31 of (m−M){sub 0}{sup M31}=24.46±0.10 mag—adopting as our calibration an LMC distance modulus of (m−M){sub 0}{sup LMC}=18.50 mag—and a fully internally consistent set of benchmark distances to key galaxies in the local volume, enabling us to establish a robust and unbiased, near-field extragalactic distance ladder.

  11. 33 CFR 117.641 - Pine River (Charlevoix).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pine River (Charlevoix). 117.641 Section 117.641 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.641 Pine River (Charlevoix). (a) The draw of the U.S. 31 bridge, mile 0.3...

  12. 33 CFR 279.6 - Overview of objective setting process.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Overview of objective setting..., DEPARTMENT OF DEFENSE RESOURCE USE: ESTABLISHMENT OF OBJECTIVES § 279.6 Overview of objective setting process... three main sets of data. Figure 1 presents an overview of this process. EC31OC91.024...

  13. 33 CFR 279.6 - Overview of objective setting process.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Overview of objective setting..., DEPARTMENT OF DEFENSE RESOURCE USE: ESTABLISHMENT OF OBJECTIVES § 279.6 Overview of objective setting process... three main sets of data. Figure 1 presents an overview of this process. EC31OC91.024...

  14. 33 CFR 279.6 - Overview of objective setting process.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Overview of objective setting..., DEPARTMENT OF DEFENSE RESOURCE USE: ESTABLISHMENT OF OBJECTIVES § 279.6 Overview of objective setting process... three main sets of data. Figure 1 presents an overview of this process. EC31OC91.024...

  15. 33 CFR 279.6 - Overview of objective setting process.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Overview of objective setting..., DEPARTMENT OF DEFENSE RESOURCE USE: ESTABLISHMENT OF OBJECTIVES § 279.6 Overview of objective setting process... three main sets of data. Figure 1 presents an overview of this process. EC31OC91.024...

  16. 33 CFR 279.6 - Overview of objective setting process.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Overview of objective setting..., DEPARTMENT OF DEFENSE RESOURCE USE: ESTABLISHMENT OF OBJECTIVES § 279.6 Overview of objective setting process... three main sets of data. Figure 1 presents an overview of this process. EC31OC91.024...

  17. 33 CFR 110.72b - St. Simons Island, Georgia.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Simons Island, Georgia. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.72b St. Simons Island, Georgia. The area beginning at a point southwest of Frederica River Bridge, St. Simons Island Causeway at latitude 31°09′58″...

  18. The CW-CRDS spectra of the 16O/18O isotopologues of ozone between 5930 and 6340 cm-1—Part 3: 16O18O18O and 18O16O18O

    NASA Astrophysics Data System (ADS)

    De Backer, M.-R.; Barbe, A.; Starikova, E.; Tyuterev, Vl. G.; Mondelain, D.; Kassi, S.; Campargue, A.

    2013-09-01

    Our systematic investigation of the high sensitivity CW-Cavity Ring Down Spectra of 16O/18O ozone isotopologues at high vibrational excitation continues with the study of the 16O18O18O and 18O16O18O species. The first two papers of this series were devoted to the analysis of the same four bands of the 16O16O18O and 16O18O16O species in the 5930-6340 cm-1domain. Here, after a brief reminder of relevant experiment and theory, we report the analyses of two bands of 16O18O18O, vibrationally assigned as 2ν2+5ν3 and 2ν1+2ν2+3ν3_2 and three bands of 18O16O18O, assigned to 2ν1+2ν2+3ν3_1, 5ν1+ν3 and 3ν1+ν2+3ν3.They correspond to the highest vibration excitations observed so far for the 16O18O18O and 18O16O18O isotopologues. Altogether for the two new bands of 16O18O18O, 1214 rovibrational transitions were assigned up to Jmax=29 and for the three new bands of 18O16O18O, 948 rovibrational transitions were assigned up to Jmax=27. Observed line positions were fitted with root-mean squares deviations ranging from 0.005 to 0.011 cm-1, using effective Hamiltonian models accounting for dark state perturbations. The derived band centres and rotational constants are in good agreement with new theoretical calculations from the molecular potential function. The corresponding lists of 3365 lines are provided as Supplementary material.

  19. 3,3-Dimethylbenzidine

    Integrated Risk Information System (IRIS)

    3,3 - Dimethylbenzidine ; CASRN 119 - 93 - 7 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcin

  20. 3,3\\'-Dichlorobenzidine

    Integrated Risk Information System (IRIS)

    3,3 ' - Dichlorobenzidine ; CASRN 91 - 94 - 1 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarci

  1. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

    PubMed

    Lüthi, Alexander U; Cullen, Sean P; McNeela, Edel A; Duriez, Patrick J; Afonina, Inna S; Sheridan, Clare; Brumatti, Gabriela; Taylor, Rebecca C; Kersse, Kristof; Vandenabeele, Peter; Lavelle, Ed C; Martin, Seamus J

    2009-07-17

    Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to the proinflammatory cytokines IL-1 beta and IL-18, but this remains unproven. Here we showed that IL-33 was processed by caspases activated during apoptosis (caspase-3 and -7) but was not a physiological substrate for caspases associated with inflammation (caspase-1, -4, and -5). Furthermore, caspase-dependent processing of IL-33 was not required for ST2 receptor binding or ST2-dependent activation of the NF-kappaB transcription factor. Indeed, caspase-dependent proteolysis of IL-33 dramatically attenuated IL-33 bioactivity in vitro and in vivo. These data suggest that IL-33 does not require proteolysis for activation, but rather, that IL-33 bioactivity is diminished through caspase-dependent proteolysis within apoptotic cells. Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33.

  2. Efficacy of a bivalent HPV 16/18 vaccine against anal HPV16/18 infection among young women: a nested analysis within the Costa Rica Vaccine Trial

    PubMed Central

    Kreimer, Aimée R.; Gonzalèz, Paula; Katki, Hormuzd A.; Porras, Carolina; Schiffman, Mark; Rodriguez, Ana Cecilia; Solomon, Diane; Jimenez, Silvia; Schiller, John T.; Lowy, Douglas R.; van Doorn, Leen-Jan; Struijk, Linda; Quint, Wim; Chen, Sabrina; Wacholder, Sholom; Hildesheim, Allan; Herrero, Rolando

    2011-01-01

    Background Anal cancer remains rare (incidence of ∼1.5 per 100,000 women annually) but rates are increasing in many countries. Human papillomavirus-16 (HPV16) infection causes most cases. We evaluated vaccine efficacy (VE) of an ASO4-adjuvanted HPV16/18 vaccine against anal HPV16/18 infection. Methods In a randomized double-blind controlled trial designed to evaluate VE against persistent cervical HPV16/18 infections and associated precancerous lesions in Costa Rica, 4210 healthy women underwent anal specimen collection (4224 of 5968= 70.8% of eligible women) at the final blinded study visit 4 years after vaccination to evaluate anal HPV16/18 VE. Cervical HPV16/18 VE among the same women at the same visit was calculated as a comparator. For this ancillary work, analyses were conducted in a restricted cohort of women both cervical HPV16/18 DNA negative and HPV 16/18 seronegative prior at enrollment (N=1989), and in the full cohort (all women with an anal specimen). Findings In the restricted cohort, VE against prevalent HPV16/18 anal infection measured one-time, four-years post-vaccination was 83.6% (95%CI 66.7% to 92.8%), which was comparable to cervical HPV16/18 VE (87.9%, 95%CI 77.4% to 94.0%). In the full cohort, HPV16/18 VE was statistically lower at the anus (62.0%, 95%CI 47.1% to 73.1%) compared to the cervix (76.4%, 95%CI 67.0% to 83.5%) (p for anatomic-site interaction =0.03). Significant and comparable VE estimates against a composite endpoint of HPV31/33/45 (i.e.: cross-protection) was observed at the anus and cervix. Interpretation The ASO4-adjuvanted vaccine affords strong protection against anal HPV, particularly among women more likely to be HPV naïve at vaccination. Funding. The Costa Rica HPV Vaccine Trial is sponsored and funded by the NCI (contract N01-CP-11005), with funding support from the National Institutes of Health Office of Research on Women's Health, and conducted with support from the Ministry of Health of Costa Rica. Vaccine was

  3. 34 CFR 33.45 - Deposit in Treasury of United States.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Deposit in Treasury of United States. 33.45 Section 33....45 Deposit in Treasury of United States. All amounts collected pursuant to this part are deposited as miscellaneous receipts in the Treasury of the United States, except as provided in 31 U.S.C. 3806(g)....

  4. 45 CFR 33.7 - Obtaining the services of a hearing official.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Obtaining the services of a hearing official. 33.7 Section 33.7 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION SALARY OFFSET... reimbursable basis pursuant to the Economy Act of 1932, as amended, 31 U.S.C. 1535. (c) The determination of...

  5. X-33. Phase 2

    NASA Technical Reports Server (NTRS)

    1998-01-01

    In response to the Cooperative Agreement, Lockheed Martin Skunk Works has compiled an Annual Performance Report of the X-33/RLV Program. This report consists of individual reports from all industry team members, as well as NASA team centers. The first milestone was hand delivered to NASA MSFC. The second year has been one of significant accomplishment in which team members have demonstrated their ability to meet vital benchmarks while continuing on the technical adventure of the 20th century.

  6. Discovery of Possible Nova in M31 : P60-M31-080723

    NASA Astrophysics Data System (ADS)

    Kasliwal, M. M.; Cenko, S. B.; Rau, A.; Ofek, E. O.; Quimby, R.; Kulkarni, S. R.

    2008-07-01

    On UT 2008 July 23.33, P60-FasTING (Palomar 60-inch Fast Transients In Nearby Galaxies) discovered a faint optical transient in M31 at RA(J2000)=00:43:27.28, DEC(J2000) = +41:10:03.3. P60-M31-080723 has a brightness of g = 19.3 +/- 0.2 (photometric calibration wrt USNO-B) and it is offset by 8.1'E,6.1'S from the center of M31. It was also marginally detected on July 22.32 at g = 19.8 +/- 0.2. It was not detected on the previous several nights with 3-sigma upper limits in table below.

  7. 31 CFR 31.213 - General standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... provision of title 18 of the U.S. Code or other provision of criminal law, Treasury shall refer such... committed a violation of Federal criminal law involving fraud, conflict of interest, bribery, or gratuity... to criminal penalties. (c) Any individual or entity who provides information or makes a...

  8. 31 CFR 31.213 - General standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provision of title 18 of the U.S. Code or other provision of criminal law, Treasury shall refer such... committed a violation of Federal criminal law involving fraud, conflict of interest, bribery, or gratuity... to criminal penalties. (c) Any individual or entity who provides information or makes a...

  9. 31 CFR 31.213 - General standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... provision of title 18 of the U.S. Code or other provision of criminal law, Treasury shall refer such... the retained entity has committed a violation of Federal criminal law involving fraud, conflict of... are subject to criminal penalties. (c) Any individual or entity that provides information or makes...

  10. 31 CFR Appendix B to Part 560 - Bulk Agricultural Commodities

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... 1005.00 Corn (Maize). 0713.31 Dried Beans including Vigna mungo (L.), Hepper, and Vigna radiata (L.) Wilczek. 0713.32 Small red (adzuki) beans. 0713.33 Kidney beans, including white pea beans. 0713.39 Beans, other. 0713.50 Broad beans and horse beans. 0713.10 Dried Peas (Pisum sativum). 0713.20...

  11. 31 CFR Appendix A to Part 538 - Bulk Agricultural Commodities

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) 0713.31 Dried Beans including Vigna mungo (L.), Hepper, and Vigna radiata (L.) Wilczek 0713.32 Small red (adzuki) beans 0713.33 Kidney beans, including white pea beans 0713.39 Beans, other 0713.50 Broad beans and horse beans 0713.10 Dried Peas (Pisum sativum) 0713.20 Chickpeas (garbanzos) 0713.40...

  12. 14 CFR 71.31 - Class A airspace.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE DESIGNATION OF CLASS A, B, C, D, AND E AIRSPACE AREAS; AIR TRAFFIC SERVICE ROUTES; AND REPORTING POINTS Class A Airspace § 71.31 Class A airspace. The airspace descriptions contained in § 71.33 and the...

  13. Potential linkages between the moisture variability in the northeastern Qaidam Basin, China, since 1800 and the East Asian summer monsoon as reflected by tree ring δ18O

    NASA Astrophysics Data System (ADS)

    Xu, Guobao; Chen, Tuo; Liu, Xiaohong; An, Wenling; Wang, Wenzhi; Yun, Hanbo

    2011-05-01

    We established the first annual resolution tree ring δ18O chronology of Qilian juniper (Sabina przewalskii Kom.) for the eastern margin of the Qaidam Basin, northwestern China. The mean tree ring cellulose δ18O in the study region (33.46‰ ± 0.99‰) was higher than that in the Qilian (28.7‰) and Helan Mountains (27.66‰), northwest China, and higher than the values in other published research (15.0‰ to 33.0‰), possibly as a result of the heavier δ18O in precipitation and the lower relative humidity (43%) during the growing season. The results of our simple correlation, bootstrap correlation, and response analyses showed that the cellulose δ18O was negatively and significantly correlated with relative humidity in July and August and that this correlation explained about 31.4% of the total variance in the moisture variability from 1954 to 2006. We also detected significant correlations among the Palmer drought severity index, the standard precipitation index, and the tree ring δ18O series. These analyses revealed that the summer relative humidity was the main limiting factor that affected δ18O values in the tree ring cellulose. Previous research indicates that the direct influence of the East Asian summer monsoon (EASM) reaches as far west as 100°E in China. However, our study revealed that the tree ring δ18O series was significantly correlated with the EASM index from 1873 to 1975, which means that the EASM influences moisture variability in the Qaidam Basin (farther west than 100°E) and that the tree ring δ18O chronology we obtained can be used as a proxy to study historical variability in the EASM.

  14. 33 CFR 137.33 - General all appropriate inquiries requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false General all appropriate inquiries requirements. 137.33 Section 137.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  15. 33 CFR 137.33 - General all appropriate inquiries requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false General all appropriate inquiries requirements. 137.33 Section 137.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  16. 33 CFR 137.33 - General all appropriate inquiries requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false General all appropriate inquiries requirements. 137.33 Section 137.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  17. 33 CFR 137.33 - General all appropriate inquiries requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false General all appropriate inquiries requirements. 137.33 Section 137.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL...

  18. 33 CFR 64.33 - Marking by the Coast Guard.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marking by the Coast Guard. 64.33 Section 64.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... Marking by the Coast Guard. (a) The District Commander may mark for the protection of maritime...

  19. 33 CFR 64.33 - Marking by the Coast Guard.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marking by the Coast Guard. 64.33 Section 64.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... Marking by the Coast Guard. (a) The District Commander may mark for the protection of maritime...

  20. 33 CFR 64.33 - Marking by the Coast Guard.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marking by the Coast Guard. 64.33 Section 64.33 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY AIDS TO... Marking by the Coast Guard. (a) The District Commander may mark for the protection of maritime...