Science.gov

Sample records for 1996-1997 fixed target

  1. Future Fixed Target Facilities

    SciTech Connect

    Melnitchouk, Wolodymyr

    2009-01-01

    We review plans for future fixed target lepton- and hadron-scattering facilities, including the 12 GeV upgraded CEBAF accelerator at Jefferson Lab, neutrino beam facilities at Fermilab, and the antiproton PANDA facility at FAIR. We also briefly review recent theoretical developments which will aid in the interpretation of the data expected from these facilities.

  2. Fixed target flammable gas upgrades

    SciTech Connect

    Schmitt, R.; Squires, B.; Gasteyer, T.; Richardson, R.

    1996-12-01

    In the past, fixed target flammable gas systems were not supported in an organized fashion. The Research Division, Mechanical Support Department began to support these gas systems for the 1995 run. This technical memo describes the new approach being used to supply chamber gasses to fixed target experiments at Fermilab. It describes the engineering design features, system safety, system documentation and performance results. Gas mixtures provide the medium for electron detection in proportional and drift chambers. Usually a mixture of a noble gas and a polyatomic quenching gas is used. Sometimes a small amount of electronegative gas is added as well. The mixture required is a function of the specific chamber design, including working voltage, gain requirements, high rate capability, aging and others. For the 1995 fixed target run all the experiments requested once through gas systems. We obtained a summary of problems from the 1990 fixed target run and made a summary of the operations logbook entries from the 1991 run. These summaries primarily include problems involving flammable gas alarms, but also include incidents where Operations was involved or informed. Usually contamination issues were dealt with by the experimenters. The summaries are attached. We discussed past operational issues with the experimenters involved. There were numerous incidents of drift chamber failure where contaminated gas was suspect. However analyses of the gas at the time usually did not show any particular problems. This could have been because the analysis did not look for the troublesome component, the contaminant was concentrated in the gas over the liquid and vented before the sample was taken, or that contaminants were drawn into the chambers directly through leaks or sub-atmospheric pressures. After some study we were unable to determine specific causes of past contamination problems, although in argon-ethane systems the problems were due to the ethane only.

  3. Mars atmospheric water vapor abundance: 1996-1997

    NASA Astrophysics Data System (ADS)

    Sprague, A. L.; Hunten, D. M.; Doose, L. R.; Hill, R. E.

    2003-05-01

    Measurements of martian atmospheric water vapor made throughout Ls = 18.0°-146.4° (October 3, 1996-July 12, 1997) show changes in Mars humidity on hourly, daily, and seasonal time scales. Because our observing program during the 1996-1997 Mars apparition did not include concomitant measurement of nearby CO 2 bands, high northern latitude data were corrected for dust and aerosol extinction assuming an optical depth of 0.8, consistent with ground-based and HST imaging of northern dust storms. All other measurements with airmass greater than 3.5 were corrected using a total optical depth of 0.5. Three dominant results from this data set are as follows: (1) pre- and post-opposition measurements made with the slit crossing many hours of local time on Mars' Earth-facing disk show a distinct diurnal pattern with highest abundances around and slightly after noon with low abundances in the late afternoon, (2) measurements of water vapor over the Mars Pathfinder landing site (Carl Sagan Memorial Station) on July 12, 1997, found 21 ppt μm in the spatial sector centered near 19° latitude, 36° longitude while abundances around the site varied from as low as 6 to as high as 28 ppt μm, and (3) water vapor abundance is patchy on hourly and daily time scales but follows the usual seasonal trends.

  4. Fixed Target Collisions at STAR

    NASA Astrophysics Data System (ADS)

    Meehan, Kathryn C.

    2016-12-01

    The RHIC Beam Energy Scan (BES) program was proposed to look for the turn-off of signatures of the quark gluon plasma (QGP), search for a possible QCD critical point, and study the nature of the phase transition between hadronic and partonic matter. Previous results have been used to claim that the onset of deconfinement occurs at a center-of-mass energy of 7 GeV. Data from lower energies are needed to test if this onset occurs. The goal of the STAR Fixed-Target Program is to extend the collision energy range in BES II to energies that are likely below the onset of deconfinement. Currently, STAR has inserted a gold target into the beam pipe and conducted test runs at center-of-mass energies of 3.9 and 4.5 GeV. Tests have been done with both Au and Al beams. First physics results from a Coulomb potential analysis of Au + Au fixed-target collisions are presented and are found to be consistent with results from previous experiments. Furthermore, the Coulomb potential, which is sensitive to the Z of the projectile and degree of baryonic stopping, will be compared to published results from the AGS.

  5. The 1994 Fermilab Fixed Target Program

    SciTech Connect

    Conrad, J. |

    1994-11-01

    This paper highlights the results of the Fermilab Fixed Target Program that were announced between October, 1993 and October, 1994. These results are drawn from 18 experiments that took data in the 1985, 1987 and 1990/91 fixed target running periods. For this discussion, the Fermilab Fixed Target Program is divided into 5 major topics: hadron structure, precision electroweak measurements, heavy quark production, polarization and magnetic moments, and searches for new phenomena. However, it should be noted that most experiments span several subtopics. Also, measurements within each subtopic often affect the results in other subtopics. For example, parton distributions from hadron structure measurements are used in the studies of heavy quark production.

  6. Oregon School-Based Health Centers 1996-1997 Services Report.

    ERIC Educational Resources Information Center

    Alexander, Tammis; Nystrom, Robert J.; Spitz, Lauren

    School based health centers (SBHC) are effective providers of health services and education because they are easy for students to access, they take an integrated and developmentally appropriate approach to meeting health needs, and they are prevention-oriented. This report describes the 1996-1997 services provided in 15 of 19 state-supported…

  7. Fixed-target physics at Fermilab

    SciTech Connect

    Bjorken, J.D.

    1985-03-01

    The Fermilab Energy Saver is now successfully commissioned and fixed-target experimentation at high energy (800 GeV) has begun. In addition, a number of new experiments designed to exploit the unique features of the Tevatron are yet to come on-line. In this talk, we will review recent accomplishments in the fixed-target program and describe experiments in progress and others yet to come.

  8. Fixed target facility at the SSC

    SciTech Connect

    Loken, S.C.; Morfin, J.G.

    1985-01-01

    The question of whether a facility for fixed target physics should be provided at the SSC must be answered before the final technical design of the SSC can be completed, particularly if the eventual form of extraction would influence the magnet design. To this end, an enthusiastic group of experimentalists, theoreticians and accelerator specialists have studied this point. The accelerator physics issues were addressed by a group led by E. Colton whose report is contained in these proceedings. The physics addressable by fixed target was considered by many of the Physics area working groups and in particular by the Structure Function Group. This report is the summary of the working group which considered various SSC fixed target experiments and determined which types of beams and detectors would be required. 13 references, 5 figures.

  9. Household hazardous waste collection results, state fiscal years 1996, 1997, 1998

    SciTech Connect

    Rion, D.

    1998-12-01

    Some household products are potentially dangerous to living things and the environment when disposed of improperly. The Illinois Environmental Protection Agency (IEPA) has designed a program to deal with such problem wastes. Utilizing funds from the Solid Waste Management Fund, the Agency sponsored 90 collections during the state fiscal years 1996, 1997, and 1998. The report details the need for household hazardous waste collections in Illinois and summarizes the results of the projects.

  10. Fixed target electroweak and hard scattering physics

    SciTech Connect

    Brock, R. ); Brown, C.N.; Montgomery, H.E. ); Corcoran, M.D. )

    1990-02-01

    The possibilities for future physics and experiments involving weak and electromagnetic interactions, neutrino oscillations, general hard scattering and experiments involving nuclear targets were explored. The studies were limited to the physics accessible using fixed target experimentation. While some of the avenues explored turn out to be relatively unrewarding in the light of competition elsewhere in the world, there are a number of positive conclusions reached about experimentation in the energy range available to the Main Injector and Tevatron. Some of the experiments would benefit from the increased intensity available from the Tevatron utilizing the Main Injector, while some require this increase. Finally, some of the experiments would use the Main Injector low energy, high intensity extracted beams directly. A program of electroweak and hard scattering experiments at fixed target energies retains the potential for important contributions to physics. The key to major parts of this program would appear to be the existence of the Main Injector. 115 refs, 17 figs.

  11. Fixed Target Beauty Physics Experimental Programs

    SciTech Connect

    Garbincius, P.H.

    1987-11-01

    The current and near term future fixed target physics efforts in observing particles with open beauty are reviewed. This includes a compilation of the non-observation upper limits and the observation of both upsilon and b-states. A short discussion of the theoretical predictions for the hadro-produced beauty pairs is included. The major part of this review is devoted to the techniques and tricks employed, a survey of the current and proposed experiments. A personal summary of the experimental prospects concludes this report. 28 refs., 26 figs.

  12. Fixed target experiments at the Fermilab Tevatron

    SciTech Connect

    Gutierrez, Gaston; Reyes, Marco A.

    2014-11-10

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of √s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include π⁺π⁻, K⁰s K⁰s, K⁰s K±π, φφ and D. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D.

  13. Fixed target experiments at the Fermilab Tevatron

    DOE PAGES

    Gutierrez, Gaston; Reyes, Marco A.

    2014-11-10

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of √s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include π⁺π⁻, K⁰s K⁰s, K⁰s K±π∓, φφ and D*±. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D*±.

  14. Charm and beauty measurements at Fermilab fixed target

    SciTech Connect

    Mishra, C.S.

    1993-10-01

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper we review recent results from charm and beauty fixed target experiments at Fermilab.

  15. Fixed-target hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2015-08-01

    Results from fixed-target hadroproduction experiments (HARP, MIPP, NA49 and NA61/SHINE) as well as their implications for cosmic ray and neutrino physics are reviewed. HARP measurements have been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve predictions of the muon yields in EAS and of the atmospheric neutrino fluxes as well as to help in the optimization of neutrino factory and super-beam designs. Recent measurements released by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment and for interpretation of EAS data. These hadroproduction experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  16. Vocational Education and Training: Directions and Resource Allocations for 1996, 1997, 1998. Report to the Ministerial Council.

    ERIC Educational Resources Information Center

    Australian National Training Authority, Brisbane.

    These three separate reports detail current and anticipated directions of vocational education and training (VET) in Australia in 1996, 1997, and 1998, respectively, and the Australian National Training Authority's recommendations regarding resource allocations for each of the 3 years. Each report examines some or all of the following: VET's…

  17. An Annotated Bibliography of HVDC Transmission and FACTS Devices, 1996-1997.

    SciTech Connect

    Litzenberger, Wayne H.; Varma, Rajiv K.; Flanagan, John D.

    1998-06-01

    This edition of the Annotated Bibliography of HVDC Transmission and FACTS Devices continues work begun in 1962 by the late Erik Bromberg, Bonneville Power Administration Librarian. His original bibliography covered the period 1932--1962. Subsequent editions were compiled by Bromberg, Val S. Lava, and Wayne Litzenberger, all of Bonneville Power Administration. Beginning with the 1991--1993 edition, the scope of the bibliography was expanded to include flexible ac transmission (FACTS) devices. This 1996--1997 edition also contains information for 1998. Preparation of the present edition took place primarily in May-June of 1998. All pertinent references have been included that were available to the editors at the time of preparation. Papers for the 1998 IEEE Winter and Summer Power Meetings and 1998 T and D Conference have been included. This edition contains the organizational affiliation of the first-named author as an aid to accessing the reference. Unfortunately, space limitations prevented the inclusion of the affiliations of all authors. Some minor editorial changes have been made to abstracts to ensure consistency in style and syntax.

  18. Determination of trifluoroacetic acid in 1996--1997 precipitation and surface waters in California and Nevada

    SciTech Connect

    Wujcik, C.E.; Cahill, T.M.; Seiber, J.N.

    1999-05-15

    The atmospheric degradation of three chlorofluorocarbon (CFC) replacement compounds, namely HFC-134a, HCFC-123, and HCFC-124, results in the formation of trifluoroacetic acid (TFA). Concentrations of TFA were determined in precipitation and surface water samples collected in California and Nevada during 1996--1997. Terminal lake systems were found to have concentrations 4--13 times higher than their calculated yearly inputs, providing evidence for accumulation. The results support dry deposition as the primary contributor of TFA to surface waters in arid and semiarid environments. Precipitation samples obtained from three different locations contained 20.7--1530 ng/L with significantly higher concentrations in fogwater over rainwater. Elevated levels of TFA were observed for rainwater collected in Nevada over those collected in California, indicating continual uptake and concentration as clouds move from a semiarid to arid climate. Thus several mechanisms exist, including evaporative concentration, vapor-liquid phase partitioning, lowered washout volumes of atmospheric deposition water, and dry deposition, which may lead to elevated concentrations of TFA in atmospheric and surface waters above levels expected from usual rainfall washout.

  19. Denitrification and nitrification in the Arctic stratosphere during the winter of 1996-1997

    NASA Astrophysics Data System (ADS)

    Kondo, Y.; Irie, H.; Koike, M.; Bodeker, G. E.

    2000-02-01

    The concentrations of HNO3, N2O, ozone, and aerosol in the lower stratosphere inside the Arctic vortex were observed by the Improved Limb Atmospheric Spectrometer (ILAS) in the winter of 1996-1997. These data demonstrate that irreversible loss of reactive nitrogen by sedimentation of HNO3 containing particles (denitrification) at 18-23 km occurred in mid-late February soon after the Arctic vortex cooled below ice saturation temperature (TICE). Denitrification exceeding 40% was observed only in air masses which experienced temperature below TICE. It occurred within 2 days in some of these air masses. Increases in HNO3 by evaporation of the particles (nitrification) at 13-15 km occurred 0-3 days after denitrification was observed, indicating particle radii of 5-10 µm or larger. It is likely that these particles were composed of nitric acid trihydrate (NAT) or NAT-coated ice particles, given that the temperatures below 16 km were higher than TICE. Continued exposure of air masses below NAT saturation temperature for 1-4 days did not lead to any significant denitrification as long as the temperature did not fall below TICE, indicating that possible nucleation of NAT at these temperatures within 4 days did not play a significant role in causing denitrification. There was little change in the average HNO3 column from February 11 to 28 since HNO3 decreases at 18-23 km were almost completely offset by increases at 12-17 km.

  20. Redistribution of nitric acid in the Arctic lower stratosphere during the winter of 1996-1997

    NASA Astrophysics Data System (ADS)

    Irie, H.; Koike, M.; Kondo, Y.; Bodeker, G. E.; Danilin, M. Y.; Sasano, Y.

    2001-10-01

    Vertical profiles of HNO3, N2O, O3, and the aerosol extinction coefficient at 780 nm were observed by the Improved Limb Atmospheric Spectrometer (ILAS) on board the Advanced Earth Observing Satellite (ADEOS) during the Arctic winter of 1996-1997. Irreversible redistribution of HNO3 is evaluated using HNO3-N2O and HNO3-O3 correlations. Denitrification and nitrification started to be observed just after the Arctic vortex cooled to below the ice frost point (TICE) on February 10. Trajectory analyses show that denitrification occurred only in air masses, which were once cooled to near TICE and were kept at temperatures below the nitric acid trihydrate saturation threshold continuously for more than 4 days. Such a temperature history provides the necessary conditions for nucleation and growth of particles causing denitrification. The average extent of denitrification at 19 km reached 43% at the center of the vortex, suggesting that stratospheric ozone could be affected by denitrification deep inside the vortex. Denitrification (>2 ppbv) and nitrification (>1 ppbv) covered 40±10% and 35±10% of the vortex area, respectively. Redistributed numbers of HNO3 molecules at each altitude were calculated by integrating the area-weighted changes in the HNO3 concentration. The decreases in total HNO3 concentration at 17-21 km in late February and early March agreed with the increases at 12-15 km to within 25%, confirming conservation of HNO3 during sedimentation and evaporation of HNO3-containing polar stratospheric cloud particles.

  1. Beauty and charm production at fixed-target experiments

    SciTech Connect

    Erik E. Gottschalk

    2003-12-10

    Fixed-target experiments continue to provide insights into the physics of particle production in strong interactions. The experiments are performed with different types of beam particles of varying energies, and many different target materials. Studies of beauty and charm production are of particular interest, since experimental results can be compared to perturbative QCD calculations. It is in this context that recent results from fixed-target experiments on beauty and charm production will be reviewed.

  2. Accelerator Science: Collider vs. Fixed Target

    SciTech Connect

    Lincoln, Don

    2016-09-07

    Particle physics experiments employ high energy particle accelerators to make their measurements. However there are many kinds of particle accelerators with many interesting techniques. One important dichotomy is whether one takes a particle beam and have it hit a stationary target of atoms, or whether one takes two counter rotating beams of particles and smashes them together head on. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of these two powerful methods of exploring the rules of the universe.

  3. Accelerator Science: Collider vs. Fixed Target

    ScienceCinema

    Lincoln, Don

    2016-09-21

    Particle physics experiments employ high energy particle accelerators to make their measurements. However there are many kinds of particle accelerators with many interesting techniques. One important dichotomy is whether one takes a particle beam and have it hit a stationary target of atoms, or whether one takes two counter rotating beams of particles and smashes them together head on. In this video, Fermilab’s Dr. Don Lincoln explains the pros and cons of these two powerful methods of exploring the rules of the universe.

  4. Beauty, charm and hyperon production at fixed-target experiments

    SciTech Connect

    Erik Gottschalk

    2002-12-11

    Over the years fixed-target experiments have performed numerous studies of particle production in strong interactions. The experiments have been performed with different types of beam particles of varying energies, and many different target materials. Since the physics of particle production is still not understood, ongoing research of phenomena that we observe as beauty, charm and strange-particle production is crucial if we are to gain an understanding of these fundamental processes. It is in this context that recent results from fixed-target experiments on beauty, charm, and hyperon production will be reviewed.

  5. Test beams and polarized fixed target beams at the NLC

    NASA Astrophysics Data System (ADS)

    Keller, Lewis; Pitthan, Rainer; Rokni, Sayed; Thompson, Kathleen; Kolomensky, Yury

    2001-07-01

    A conceptual program to use NLC beams for test beams and fixed target physics is described. Primary undisrupted polarized beams would be the most simple to use, but for NLC, the disrupted beams are of good enough quality that they could also be used, after collimation of the low energy tails, for test beams and fixed target physics. Pertinent issues are: what is the compelling physics, what are the requirements on beams and running time, and what is the impact on colliding beam physics running. A list of physics topics is given; one topic (Mo/ller Scattering) is treated in more depth.

  6. Low-dose fixed-target serial synchrotron crystallography.

    PubMed

    Owen, Robin L; Axford, Danny; Sherrell, Darren A; Kuo, Anling; Ernst, Oliver P; Schulz, Eike C; Miller, R J Dwayne; Mueller-Werkmeister, Henrike M

    2017-04-01

    The development of serial crystallography has been driven by the sample requirements imposed by X-ray free-electron lasers. Serial techniques are now being exploited at synchrotrons. Using a fixed-target approach to high-throughput serial sampling, it is demonstrated that high-quality data can be collected from myoglobin crystals, allowing room-temperature, low-dose structure determination. The combination of fixed-target arrays and a fast, accurate translation system allows high-throughput serial data collection at high hit rates and with low sample consumption.

  7. Test Beams and Polarized Fixed Target Beams at the NLC

    SciTech Connect

    Pitthan, Rainer

    2001-01-17

    A conceptual program to use NLC beams for test beams and fixed target physics is described. Primary undisrupted polarized beams would be the most simple to use, but for NLC, the disrupted beams are of good enough quality that they could also be used, after collimation of the low energy tails, for test beams and fixed target physics. Pertinent issues are: what is the compelling physics, what are the requirements on beams and running time, and what is the impact on colliding beam physics running. A list of physics topics is given; one topic (Moeller Scattering) is treated in more depth.

  8. A new Mtest beamline for the 1999 fixed target run

    SciTech Connect

    C. N. Brown and T. R. Kobilarcik

    2000-05-18

    The beamline cryogenic system for the Meson area will not be run for the 1999 fixed target run. The current MTest (MT) beamline relies on cryogenic magnets. A non-cryogenic solution is proposed which can yield up to 1 x 10{sup 6} pions per cycle at 120 GeV/c per 1 x 10{sup 11} incident protons at 800 GeV/c.

  9. NASA/FAA/NCAR Supercooled Large Droplet Icing Flight Research: Summary of Winter 1996-1997 Flight Operations

    NASA Technical Reports Server (NTRS)

    Miller, Dean; Ratvasky, Thomas; Bernstein, Ben; McDonough, Frank; Strapp, J. Walter

    1998-01-01

    During the winter of 1996-1997, a flight research program was conducted at the NASA-Lewis Research Center to study the characteristics of Supercooled Large Droplets (SLD) within the Great Lakes region. This flight program was a joint effort between the National Aeronautics and Space Administration (NASA), the National Center for Atmospheric Research (NCAR), and the Federal Aviation Administration (FAA). Based on weather forecasts and real-time in-flight guidance provided by NCAR, the NASA-Lewis Icing Research Aircraft was flown to locations where conditions were believed to be conducive to the formation of Supercooled Large Droplets aloft. Onboard instrumentation was then used to record meteorological, ice accretion, and aero-performance characteristics encountered during the flight. A total of 29 icing research flights were conducted, during which "conventional" small droplet icing, SLD, and mixed phase conditions were encountered aloft. This paper will describe how flight operations were conducted, provide an operational summary of the flights, present selected experimental results from one typical research flight, and conclude with practical "lessons learned" from this first year of operation.

  10. Atmospheric electric conductivity measurements over the Indian Ocean during the Indian Antarctic Expedition in 1996-1997

    NASA Astrophysics Data System (ADS)

    Deshpande, C. G.; Kamra, A. K.

    2002-11-01

    The atmospheric electric conductivity measurements made over the Indian Ocean with a Gerdien's apparatus mounted aboard MV Polarbird during the XVI Indian Scientific Expedition in 1996-1997 are reported. Simultaneous three-hourly measurements of aerosol concentrations of 13-1000 nm size and some meteorological parameters are also reported. Latitudinal variation of conductivity along the cruise route shows a minimum at ˜28°S. Further, the variations in conductivity in the 10°N-20°S and 60°-70°S latitudinal belts show opposite trends on the outward and return cruises, which fall near to the onset and withdrawal phases of the northeast monsoon season, respectively. The results are explained on the basis of the well-known northward shift of the subsidence leg of the southern Hadley cell and of the position of the Intertropical Convergence Zone during the months of March-April in this region and the observations of the cyclonic systems near the continent of Antarctica during the period of outward cruise.

  11. Electron beam ion trap bi-annual report 1996/1997

    SciTech Connect

    Schneider, D

    1999-01-05

    and polarization measurements on high-Z highly charged ions. Studies of the interaction of highly charged ions with solid surfaces and thin foil targets reveal new interaction phenomena. The measurements of high secondary ion sputter yields led to the development of a prototype electron/ion emission microscope, which allows simultaneous topographic and chemical composition analysis with high sensitivity and spatial resolution. The enabling technology to trap, confine, and cool hundreds of highly charged ions in a precision Penning trap has been established and first evidence for the formation of a strongly coupled highly charged ion plasma via a sympathetic laser/ion cooling scheme has been observed. The benefits to DOE programs for a continued long term EBIT program are evident. The program requires the application and development of state-of-the-art experimental techniques necessary for spectroscopy, ion confinement and manipulation with spin-off applications in other laboratory programs. Thus, it serves as an excellent training ground for young scientists who will later work on energy-related plasma research or similar areas. It promises new research results towards the growth of our understanding of basic physics phenomena in atomic, nuclear and plasma physics, such as solid phases, astrophysical plasma evolution, and quantum control. This reserach will also provide input for applications in areas like ion beam manipulation and control for materials research. The activities at EBIT have created great interest among scientists from other areas (e.g. biology and environmental sciences) with several new ideas and research directions emerging. External funding for the project has in part been provided by the DOE office of Basic Energy Science (Chemical Science Division) and by NASA.

  12. Preliminary design implications of SSC fixed-target operation

    SciTech Connect

    Zisman, M.S.

    1984-06-01

    This paper covers some of the accelerator physics issues relevant to a possible fixed-target operating mode for the Superconducting Super Collider (SSC). In the brief time available, no attempt has been made to design this capability into the SSC. Rather, I have tried to evaluate what the performance of such a machine might be, and to indicate the hardware implications and extraction considerations that would be part of an actual design study. Where appropriate, parameters and properties of the present LBL design for the SSC have been used; these should be taken as being representative of the general class of small-aperture, high-field colliders being considered by the accelerator physics community. Thus, the numerical examples given here must ultimately be reexamined in light of the actual parameters of the particular accelerator being considered.

  13. Interaction, 1996-1997.

    ERIC Educational Resources Information Center

    Hajdu-Vaughn, Susan, Ed.; Coyle, Barbara, Ed.

    1997-01-01

    This collection includes four quarterly issues of "Interaction," a publication of the Canadian Child Care Federation. Each issue addresses several topics and is arranged in four sections: opinions, practice/pratique, focus/a propos, and news/nouvelles. The opinions section includes letters and editorial/review columns, the practice…

  14. [Endocrinology 1996-1997].

    PubMed

    Schreiber, V

    1998-04-06

    Post-traumatic stress-induced disorders are still the focus of interest and most recently discussions are under way whether stress-induced cortisol excess leads to atrophy of the brain. In investigation on carcinogenesis the first reports were published on the use of antisense-oligonucleotides during inhibition of the development of tumours by a humoral mechanism and on the gene-based neuroendocrine differentiation of the lungs, perhaps associated with the basis for the development of small cell carcinoma. The oncogenic action of superoxides has also humoral mediators. Interest in nitrogen oxide is focused on two areas: inflammations and hypertension. Intraluminal NO concentrations increase in asthma 2-10x, in cystitis 30-100x, in Crohn's disease 20-200x. Humoral mechanisms in asthma offer new drugs--inhibitors of the development or action of leucotrienes. The basal NO production is reduced in "essential" hypertension but it is not known whether it is the cause or consequence. IGF-I increases the formation of NO in the vascular wall and thus perhaps reduces vascular contractility. As far as IGF is concerned, it is obvious that if recombinant preparations will be available, they will be tested in amyotrophic lateral sclerosis, myotonic dystrophy, multiple sclerosis, catabolic conditions, osteoporosis, in renal failure and to promote wound healing. STH may also prove useful in cardiac failure, in particular in cardiac cachexia. That TRH has receptors in the gut is not surprising, it acts, however, even there via TSH. Thrombopoietin is being tested in clinical trials. Neocytolysis is a new phenomenon: when erythropoietin secretion declines new erythrocytes disappear and only old ones remain in the blood stream. Alpha-adducin is a renal tubular protein, regulating the sodium balance.

  15. In celebration of the fixed target program with the Tevatron

    SciTech Connect

    Jeffrey A. Appel et al.

    2001-12-28

    The Tevatron is the world's first large superconducting accelerator. With its construction, we gained the dual opportunities to advance the state of the art in accelerator technology with the machine itself and in particle physics with the experiments that became possible in a higher energy regime. There have been 43 experiments in the Tevatron fixed target program. Many of these are better described as experimental programs, each with a broad range of physics goals and results, and more than 100 collaborating physicists and engineers. The results of this program are three-fold: (1) new technologies in accelerators, beams and detectors which advanced the state of the art; (2) new experimental results published in the refereed physics journals; and (3) newly trained scientists who are both the next generation of particle physicists and an important part of the scientific, technical and educational backbone of the country as a whole. In this book they compile these results. There are sections from each experiment including what their physics goals and results were, what papers were published, and which students have received degrees. Summaries of these results from the program as a whole are quite interesting, but the physics results from this program are too broad to summarize globally. The most important of the results appear in later sections of this booklet.

  16. Renaissance of the ~ 1-TeV Fixed-Target Program

    SciTech Connect

    Adams, T.; Appel, J.A.; Arms, K.E.; Balantekin, A.B.; Conrad, J.M.; Cooper, P.S.; Djurcic, Z.; Dunwoodie, W.; Engelfried, J.; Fisher, P.H.; Gottschalk, Erik Edward; de Gouvea, A.; Heller, K.; Ignarra, C.M.; Karagiorgi, G.; Kwan, S.; Loinaz, W.A.; Meadows, B.; Moore, R.; Morfin, J.G.; Naples, D.; /Pittsburgh U. /St. Mary's Coll., Minnesota /New Mexico State U. /Michigan U. /Wayne State U. /South Carolina U. /Florida U. /Carnegie Mellon U. /Cincinnati U. /Columbia U. /Columbia U. /Northwestern U. /Yale U. /Fermilab /Argonne /Northwestern U. /APC, Paris

    2011-12-02

    This document describes the physics potential of a new fixed-target program based on a {approx}1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  17. Renaissance of the ~1 TeV Fixed-Target Program

    SciTech Connect

    Adams, T.; Appel, Jeffrey A.; Arms, Kregg Elliott; Balantekin, A.B.; Conrad, Janet Marie; Cooper, Peter S.; Djurcic, Zelimir; Dunwoodie, William M.; Engelfried, Jurgen; Fisher, Peter H.; Gottschalk, E.; /Fermilab /Northwestern U.

    2009-05-01

    This document describes the physics potential of a new fixed-target program based on a {approx} TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  18. Renaissance of the {approximately} 1-TeV fixed-target program.

    SciTech Connect

    Adams, T.; Appel, J. A.; Arms, K. E.; Balantekin, A. B.; Conrad, J. M.; Tait, T. M. P.; High Energy Physics; Amherst Coll.; Univ. of Wisconsin at Madison; Massachuetts Inst. of Tech.

    2010-01-01

    This document describes the physics potential of a new fixed-target program based on a {approx}1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  19. The future of fixed target physics: Snowmass E5 working group summary

    SciTech Connect

    Krishna Kumar et al.

    2002-12-10

    Fixed target experimentation remains a vigorous and important tool. In many cases it provides the best technique to study elementary physics. Here the authors explore several areas, where, in the near future, fixed target experiments have the potential to alter the understanding of physics. These include, but are clearly not limited to, high precision tests of CP violation in the Kaon sector, ultra-precise determination of the weak mixing angle and its evolution, and lepton flavor violation.

  20. Fixed lag smoothing target tracking in clutter for a high pulse repetition frequency radar

    NASA Astrophysics Data System (ADS)

    Khan, Uzair; Shi, Yi Fang; Song, Taek Lyul

    2015-12-01

    A new method to smooth the target hybrid state with Gaussian mixture measurement likelihood-integrated track splitting (GMM-ITS) in the presence of clutter for a high pulse repetition frequency (HPRF) radar is proposed. This method smooths the target state at fixed lag N and considers all feasible multi-scan target existence sequences in the temporal window of scans in order to smooth the target hybrid state. The smoothing window can be of any length N. The proposed method to smooth the target hybrid state at fixed lag is also applied to the enhanced multiple model (EMM) tracking algorithm. Simulation results indicate that the performance of fixed lag smoothing GMM-ITS significantly improves false track discrimination and root mean square errors (RMSEs).

  1. A fixed-target programme at the LHC (AFTER@LHC)

    NASA Astrophysics Data System (ADS)

    Trzeciak, Barbara; AFTER@LHC study group

    2017-01-01

    We report on the perspectives for hadron, heavy-ion and spin physics with a multi-purpose fixed-target programme using the LHC multi-TeV proton and heavy-ion beams (AFTER@LHC). This would be the most energetic fixed-target experiment opening new domains of particle and nuclear physics and complementing current and future collider programmes. Thanks to the large boost, one can fully access –with conventional detectors– the backward hemisphere in the center-of-mass system which allows for studies of the largely uncharted high-x region (xF → -1).

  2. Head perturbations during walking while viewing a head-fixed target

    NASA Technical Reports Server (NTRS)

    Das, Vallabh E.; Zivotofsky, Ari Z.; Discenna, Alfred O.; Leigh, R. John

    1995-01-01

    Inexpensive, head-fixed computer displays are now available that subjects can wear during locomotion. Our hypothesis is that viewing a head-fixed visual display will change the character- istics of rotational head perturbations during natural walking. Using a 3-axis angular rate sensor, we measured head rotations during natural or treadmill walking, in 10 normal subjects and 2 patients with deficient vestibular function, as they attempted to view (1) a stationary target at optical infinity; and (2) a target at a distance of 20 cm rigidly attached to the head. Normal subjects and patients showed no significant change in the predominant frequency of head rotations in any plane (ranging 0.7-5.7 Hz) during the two different viewing tasks. Mean peak head velocities also showed no difference during the two viewing conditions except in the yaw plane, in which values were greater while viewing the near target. Predominant frequencies of head rotations were similar in the pitch plane during natural or treadmill walking; however, peak velocities of pitch head rotations were substantially greater during natural walking. One vestibular patient showed modest increases of head velocity during natural walking compared with normal subjects. Rotational head perturbations that occur during natural walking are largely unaffected when subjects view a head-fixed target. There is need to study how such perturbations, which induce vestibular eye movements, affect vision of head-fixed displays.

  3. The fixed target experiment for studies of baryonic matter at the Nuclotron (BM@N)

    NASA Astrophysics Data System (ADS)

    Kapishin, Mikhail

    2016-08-01

    BM@N (Baryonic Matter at Nuclotron) is the first experiment to be realized at the accelerator complex of NICA-Nuclotron. The aim of the BM@N experiment is to study interactions of relativistic heavy-ion beams with fixed targets. The BM@N setup, results of Monte Carlo simulations and the BM@N experimental program are presented.

  4. Overview of results from the Fermilab fixed target and collider experiments

    SciTech Connect

    Montgomery, H.E.

    1997-06-01

    In this paper we present a review of recent QCD related results from Fermilab fixed target and collider experiments. Topics covered range from structure functions through W/Z production, heavy quark production and jet angular distributions. We also include the current state of knowledge about leptoquark pair production in hadronic collisions.

  5. General Quantum Meet-in-the-Middle Search Algorithm Based on Target Solution of Fixed Weight

    NASA Astrophysics Data System (ADS)

    Fu, Xiang-Qun; Bao, Wan-Su; Wang, Xiang; Shi, Jian-Hong

    2016-10-01

    Similar to the classical meet-in-the-middle algorithm, the storage and computation complexity are the key factors that decide the efficiency of the quantum meet-in-the-middle algorithm. Aiming at the target vector of fixed weight, based on the quantum meet-in-the-middle algorithm, the algorithm for searching all n-product vectors with the same weight is presented, whose complexity is better than the exhaustive search algorithm. And the algorithm can reduce the storage complexity of the quantum meet-in-the-middle search algorithm. Then based on the algorithm and the knapsack vector of the Chor-Rivest public-key crypto of fixed weight d, we present a general quantum meet-in-the-middle search algorithm based on the target solution of fixed weight, whose computational complexity is \\sumj = 0d {(O(\\sqrt {Cn - k + 1d - j }) + O(C_kj log C_k^j))} with Σd i =0 Ck i memory cost. And the optimal value of k is given. Compared to the quantum meet-in-the-middle search algorithm for knapsack problem and the quantum algorithm for searching a target solution of fixed weight, the computational complexity of the algorithm is lower. And its storage complexity is smaller than the quantum meet-in-the-middle-algorithm. Supported by the National Basic Research Program of China under Grant No. 2013CB338002 and the National Natural Science Foundation of China under Grant No. 61502526

  6. Their World, 1996/1997.

    ERIC Educational Resources Information Center

    Their World, 1996

    1996-01-01

    The 26 articles in this annual on learning disabilities (LD) are organized into the following categories: research articles, educator resources, educational practices, creativity, professional insights, the LD experience of youth and adults, explaining LD to a child, and parents' trials and tribulations. The articles are: "National Institute of…

  7. Tracking target and distractor processing in fixed-feature visual search: evidence from human electrophysiology.

    PubMed

    Jannati, Ali; Gaspar, John M; McDonald, John J

    2013-12-01

    Salient distractors delay visual search for less salient targets in additional-singleton tasks, even when the features of the stimuli are fixed across trials. According to the salience-driven selection hypothesis, this delay is due to an initial attentional deployment to the distractor. Recent event-related potential (ERP) studies found no evidence for salience-driven selection in fixed-feature search, but the methods employed were not optimized to isolate distractor ERP components such as the N2pc and distractor positivity (PD; indices of selection and suppression, respectively). Here, we isolated target and distractor ERPs in two fixed-feature search experiments. Participants searched for a shape singleton in the presence of a more-salient color singleton (Experiment 1) or for a color singleton in the presence of a less-salient shape singleton (Experiment 2). The salient distractor did not elicit an N2pc, but it did elicit a PD on fast-response trials. Furthermore, distractors had no effect on the timing of the target N2pc. These results indicate that (a) the distractor was prevented from engaging the attentional mechanism associated with N2pc, (b) the distractor did not interrupt the deployment of attention to the target, and (c) competition for attention can be resolved by suppressing locations of irrelevant items on a salience-based priority map.

  8. An Application of a Kalman Filter Fixed Interval Smoothing Algorithm to Underwater Target Tracking

    DTIC Science & Technology

    1989-03-01

    FIXED INTERVAL SMOOTHING ALGORITHM TO UNDERWATER TARGET TRACKING 12 Personal Author(s) Richard B. Nicidas 13a Type of Report 13b Time Covered 14 Date of...Terms (cnrln. on e’ rze ifnecessary and idewiify by block number) Field Group Subgroup Kalman Filter, smoothing algorithm, torpedo tracking. 19 Abstract... Smoothing Algorithm to optimally smooth data tracks generated by the short base-line tracking ranges at the Naval Torpedo Station, Keyport, Washington. The

  9. Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007).

    PubMed

    Pérez-Trallero, Emilio; Martín-Herrero, Jose E; Mazón, Ana; García-Delafuente, Celia; Robles, Purificación; Iriarte, Victor; Dal-Ré, Rafael; García-de-Lomas, Juan

    2010-07-01

    A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of > or = 2 microg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a beta-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLS(B)) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), beta-lactamase production (from 25.7% to 15.7%), and beta-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLS(B) was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes.

  10. Antimicrobial Resistance among Respiratory Pathogens in Spain: Latest Data and Changes over 11 Years (1996-1997 to 2006-2007)▿

    PubMed Central

    Pérez-Trallero, Emilio; Martín-Herrero, Jose E.; Mazón, Ana; García-Delafuente, Celia; Robles, Purificación; Iriarte, Victor; Dal-Ré, Rafael; García-de-Lomas, Juan

    2010-01-01

    A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of ≥2 μg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a β-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLSB) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), β-lactamase production (from 25.7% to 15.7%), and β-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLSB was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes. PMID:20439616

  11. High Transverse Momentum Direct Photon Production at Fermilab Fixed-Target Energies

    SciTech Connect

    Apanasevich, Leonard

    2005-01-01

    This thesis describes a study of the production of high transverse momentum direct photons and π0 mesons by proton beams at 530 and 800 GeV/c and π- beams at 515 GeV/c incident on beryllium, copper, and liquid hydrogen targets. The data were collected by Fermilab experiment E706 during the 1990 and 1991-92 fixed target runs. The apparatus included a large, finely segmented lead and liquid argon electromagnetic calorimeter and a charged particle spectrometer featuring silicon strip detectors in the target region and proportional wire chambers and drift tubes downstream of a large aperture analysis magnet. The inclusive cross sections are presented as functions of transverse momentum and rapidity. The measurements are compared with next-to-leading order perturbative QCD calculations and to results from previous experiments.

  12. Testing GeV-scale dark matter with fixed-target missing momentum experiments

    NASA Astrophysics Data System (ADS)

    Izaguirre, Eder; Krnjaic, Gordan; Schuster, Philip; Toro, Natalia

    2015-05-01

    We describe an approach to detect dark matter and other invisible particles with mass below a GeV, exploiting missing energy-momentum measurements and other kinematic features of fixed-target production. In the case of an invisibly decaying MeV-GeV-scale dark photon, this approach can improve on present constraints by 2-6 orders of magnitude over the entire mass range, reaching sensitivity as low as ɛ2˜1 0-14 . Moreover, the approach can explore essentially all of the viable parameter space for thermal or asymmetric dark matter annihilating through the vector portal.

  13. Preparation of a primary argon beam for the CERN fixed target physics.

    PubMed

    Küchler, D; O'Neil, M; Scrivens, R; Thomae, R

    2014-02-01

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar(11+) beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  14. Physics Opportunities of a Fixed-Target Experiment using the LHC Beams

    SciTech Connect

    Brodsky, S.J.; Fleuret, F.; Hadjidakis, C.; Lansberg, J.P.; /Orsay, IPN

    2012-03-16

    We outline the many physics opportunities offered by a multi-purpose fixed-target experiment using the proton and lead-ion beams of the LHC extracted by a bent crystal. In a proton run with the LHC 7-TeV beam, one can analyze pp, pd and pA collisions at center-of-mass energy {radical}s{sub NN} {approx_equal} 115 GeV and even higher using the Fermi motion of the nucleons in a nuclear target. In a lead run with a 2.76 TeV-per-nucleon beam, {radical}s{sub NN} is as high as 72 GeV. Bent crystals can be used to extract about 5 x 10{sup 8} protons/sec; the integrated luminosity over a year reaches 0.5 fb{sup -1} on a typical 1 cm-long target without nuclear species limitation. We emphasize that such an extraction mode does not alter the performance of the collider experiments at the LHC. By instrumenting the target-rapidity region, gluon and heavy-quark distributions of the proton and the neutron can be accessed at large x and even at x larger than unity in the nuclear case. Single diffractive physics and, for the first time, the large negative-xF domain can be accessed. The nuclear target-species versatility provides a unique opportunity to study nuclear matter versus the features of the hot and dense matter formed in heavy-ion collisions, including the formation of the quark-gluon plasma, which can be studied in PbA collisions over the full range of target-rapidity domain with a large variety of nuclei. The polarization of hydrogen and nuclear targets allows an ambitious spin program, including measurements of the QCD lensing effects which underlie the Sivers single-spin asymmetry, the study of transversity distributions and possibly of polarized parton distributions. We also emphasize the potential offered by pA ultra-peripheral collisions where the nucleus target A is used as a coherent photon source, mimicking photoproduction processes in ep collisions. Finally, we note that W and Z bosons can be produced and detected in a fixed-target experiment and in their

  15. Testing sterile neutrinos with new fixed target experiment at CERN SPS

    NASA Astrophysics Data System (ADS)

    Gorbunov, D. S.

    2015-03-01

    We discuss the recently proposed new fixed target experiment at CERN with SPS beam of 400 GeV protons aimed at searches for sterile neutrinos produced in charmed hadron decays. The three sterile neutrino introduced to the Standard Model can explain the active neutrino masses and mixings by means of seesaw type I mechanism, baryon asymmetry of the Universe by making use of leptogenesis via sterile-active neutrino oscillations in the primordial plasma, and dark matter phenomenon due to a relic component of the lightest sterile neutrino. The new beam-dump with detector placed as close to the target as possible will allow to test many other extensions of the Standard Model with new unstable yet long-lived particles at GeV mass scale.

  16. Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations

    PubMed Central

    Sadick, Jessica S.; Boutin, Molly E.; Hoffman-Kim, Diane; Darling, Eric M.

    2016-01-01

    Cellular heterogeneity is inherent in most human tissues, making the investigation of specific cell types challenging. Here, we describe a novel, fixation/intracellular target-based sorting and protein extraction method to provide accurate protein characterization for cell subpopulations. Validation and feasibility tests were conducted using homogeneous, neural cell lines and heterogeneous, rat brain cells, respectively. Intracellular proteins of interest were labeled with fluorescent antibodies for fluorescence-activated cell sorting. Reproducible protein extraction from fresh and fixed samples required lysis buffer with high concentrations of Tris-HCl and sodium dodecyl sulfate as well as exposure to high heat. No deterioration in protein amount or quality was observed for fixed, sorted samples. For the feasibility experiment, a primary rat subpopulation of neuronal cells was selected for based on high, intracellular β-III tubulin signal. These cells showed distinct protein expression differences from the unsorted population for specific (phosphorylated tau) and non-specific (total tau) protein targets. Our approach allows for determining more accurate protein profiles directly from cell types of interest and provides a platform technology in which any cell subpopulation can be biochemically investigated. PMID:27666089

  17. Limitations to very high rate wire chambers in fixed target geometries

    SciTech Connect

    Spiegel, L.

    1989-11-01

    The task is to explore physical limitations to the operation of wire chambers in fixed target geometries at an interaction rate of 52 MHz (chosen as it corresponds to the FNAL accelerator rf rate.) That is, to see if there are physical limitations to the operation of gaseous wire chambers at such a high operating rate. A primary proton beam energy of 800 GeV has been assumed although modest increases in the primary energy should not affect the basic conclusion as secondary multiplicity increases logarithmically with center-of-momentum energy. By sustaining a 52 MHz interaction rate it is meant that results from a given interaction are electronically isolated from preceding and subsequent rf buckets, good wire plane efficiency is maintained throughout the active region of the chamber, and the chamber operates in a stable manner throughout the course of a typical fixed target run -- six months to a full year. Other working assumptions include the understanding that chamber electronics -- amplifiers, discriminators, delay elements, encoders -- will not suffer degradation at 52 MHz and that the intensely populated beam regions have been somehow excluded from the chambers. 7 refs., 2 figs.

  18. Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations.

    PubMed

    Sadick, Jessica S; Boutin, Molly E; Hoffman-Kim, Diane; Darling, Eric M

    2016-09-26

    Cellular heterogeneity is inherent in most human tissues, making the investigation of specific cell types challenging. Here, we describe a novel, fixation/intracellular target-based sorting and protein extraction method to provide accurate protein characterization for cell subpopulations. Validation and feasibility tests were conducted using homogeneous, neural cell lines and heterogeneous, rat brain cells, respectively. Intracellular proteins of interest were labeled with fluorescent antibodies for fluorescence-activated cell sorting. Reproducible protein extraction from fresh and fixed samples required lysis buffer with high concentrations of Tris-HCl and sodium dodecyl sulfate as well as exposure to high heat. No deterioration in protein amount or quality was observed for fixed, sorted samples. For the feasibility experiment, a primary rat subpopulation of neuronal cells was selected for based on high, intracellular β-III tubulin signal. These cells showed distinct protein expression differences from the unsorted population for specific (phosphorylated tau) and non-specific (total tau) protein targets. Our approach allows for determining more accurate protein profiles directly from cell types of interest and provides a platform technology in which any cell subpopulation can be biochemically investigated.

  19. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics.

    PubMed

    Munchel, Sarah; Hoang, Yen; Zhao, Yue; Cottrell, Joseph; Klotzle, Brandy; Godwin, Andrew K; Koestler, Devin; Beyerlein, Peter; Fan, Jian-Bing; Bibikova, Marina; Chien, Jeremy

    2015-09-22

    Current genomic studies are limited by the poor availability of fresh-frozen tissue samples. Although formalin-fixed diagnostic samples are in abundance, they are seldom used in current genomic studies because of the concern of formalin-fixation artifacts. Better characterization of these artifacts will allow the use of archived clinical specimens in translational and clinical research studies. To provide a systematic analysis of formalin-fixation artifacts on Illumina sequencing, we generated 26 DNA sequencing data sets from 13 pairs of matched formalin-fixed paraffin-embedded (FFPE) and fresh-frozen (FF) tissue samples. The results indicate high rate of concordant calls between matched FF/FFPE pairs at reference and variant positions in three commonly used sequencing approaches (whole genome, whole exome, and targeted exon sequencing). Global mismatch rates and C · G > T · A substitutions were comparable between matched FF/FFPE samples, and discordant rates were low (<0.26%) in all samples. Finally, low-pass whole genome sequencing produces similar pattern of copy number alterations between FF/FFPE pairs. The results from our studies suggest the potential use of diagnostic FFPE samples for cancer genomic studies to characterize and catalog variations in cancer genomes.

  20. Quarkonium Physics at a Fixed-Target Experiment Using the LHC Beams

    SciTech Connect

    Lansberg, J.P.; Brodsky, S.J.; Fleuret, F.; Hadjidakis, C.; /Orsay, IPN

    2012-04-09

    We outline the many quarkonium-physics opportunities offered by a multi-purpose fixed-target experiment using the p and Pb LHC beams extracted by a bent crystal. This provides an integrated luminosity of 0.5 fb{sup -1} per year on a typical 1cm-long target. Such an extraction mode does not alter the performance of the collider experiments at the LHC. With such a high luminosity, one can analyse quarkonium production in great details in pp, pd and pA collisions at {radical}s{sub NN} {approx_equal} 115 GeV and at {radical}s{sub NN} {approx_equal} 72 GeV in PbA collisions. In a typical pp (pA) run, the obtained quarkonium yields per unit of rapidity are 2-3 orders of magnitude larger than those expected at RHIC and about respectively 10 (70) times larger than for ALICE. In PbA, they are comparable. By instrumenting the target-rapidity region, the large negative-x{sub F} domain can be accessed for the first time, greatly extending previous measurements by Hera-B and E866. Such analyses should help resolving the quarkonium-production controversies and clear the way for gluon PDF extraction via quarkonium studies. The nuclear target-species versatility provides a unique opportunity to study nuclear matter and the features of the hot and dense matter formed in PbA collisions. A polarised proton target allows the study of transverse-spin asymmetries in J/{Psi} and {Upsilon} production, providing access to the gluon and charm Sivers functions.

  1. The unified database for the fixed target experiment BM@N

    NASA Astrophysics Data System (ADS)

    Gertsenberger, K. V.

    2016-09-01

    The article describes the developed database designed as comprehensive data storage of the fixed target experiment BM@N [1] at Joint Institute for Nuclear Research (JINR) in Dubna. The structure and purposes of the BM@N facility will be briefly presented. The scheme of the unified database and its parameters will be described in detail. The use of the BM@N database implemented on the PostgreSQL database management system (DBMS) allows one to provide user access to the actual information of the experiment. Also the interfaces developed for the access to the database will be presented. One was implemented as the set of C++ classes to access the data without SQL statements, the other-Web-interface being available on the Web page of the BM@N experiment.

  2. Measurement of strange particle production in the NICA fixed-target programme

    NASA Astrophysics Data System (ADS)

    Friese, Volker

    2016-08-01

    Strange particles provide a sensitive tool to study the dense and hot matter created in relativistic nuclear collisions. Although strangeness production in such collisions has been a topic of experimental and theoretical research for many years, its understanding is far from being complete. This holds in particular for multi-strange hyperons and for lower collision energies as relevant for NICA and FAIR. Multi-strange particles, being sensitive to both the mechanism of strangeness production and the net-baryon density, are expected to shed light on the state of the created matter and to indicate possible transitions to new phases of strongly interacting matter. We thus advocate the measurement of hyperons and φ mesons in a fixed-target experiment at NICA (BM@N), which can be achieved by a relatively compact detector system.

  3. Low-Z polymer sample supports for fixed-target serial femtosecond X-ray crystallography

    SciTech Connect

    Feld, Geoffrey K.; Heymann, Michael; Benner, W. Henry; Pardini, Tommaso; Tsai, Ching -Ju; Boutet, Sebastien; Coleman, Matthew A.; Hunter, Mark S.; Li, Xiaodan; Messerschmidt, Marc; Opathalage, Achini; Pedrini, Bill; Williams, Garth J.; Krantz, Bryan A.; Fraden, Seth; Hau-Riege, Stefan; Evans, James E.; Segelke, Brent W.; Frank, Matthias

    2015-06-27

    X-ray free-electron lasers (XFELs) offer a new avenue to the structural probing of complex materials, including biomolecules. Delivery of precious sample to the XFEL beam is a key consideration, as the sample of interest must be serially replaced after each destructive pulse. The fixed-target approach to sample delivery involves depositing samples on a thin-film support and subsequent serial introduction via a translating stage. Some classes of biological materials, including two-dimensional protein crystals, must be introduced on fixed-target supports, as they require a flat surface to prevent sample wrinkling. A series of wafer and transmission electron microscopy (TEM)-style grid supports constructed of low-Z plastic have been custom-designed and produced. Aluminium TEM grid holders were engineered, capable of delivering up to 20 different conventional or plastic TEM grids using fixed-target stages available at the Linac Coherent Light Source (LCLS). As proof-of-principle, X-ray diffraction has been demonstrated from two-dimensional crystals of bacteriorhodopsin and three-dimensional crystals of anthrax toxin protective antigen mounted on these supports at the LCLS. In conclusion, the benefits and limitations of these low-Z fixed-target supports are discussed; it is the authors' belief that they represent a viable and efficient alternative to previously reported fixed-target supports for conducting diffraction studies with XFELs.

  4. Proposed Fermilab fixed target experiment: Kaons at the Tevatron. Environmental Assessment

    SciTech Connect

    Not Available

    1993-12-01

    The US Department of Energy (DOE) has prepared an Environmental Assessment (EA), DOE/EA-0898, evaluating the impacts associated with the proposed fixed target experiment at the Fermi National Accelerator Laboratory (Femilab) in Batavia, Illinois, known as Kaons at the Tevatron (KTeV). The proposed KTeV project includes reconfiguration of an existing target station, enhancement of an existing beam transport system connected to existing utility facilities, and construction of a new experimental detector hall area. The study of the K meson, a type of subatomic particle, has been going on at Fermilab for 20 years. The proposed KTEV project advances the search for the origins of a violation of a fundamental symmetry of nature called charge parity (CP) violation. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement is not required.

  5. Theoretical framework to analyze searches for hidden light gauge bosons in electron scattering fixed target experiments

    NASA Astrophysics Data System (ADS)

    Beranek, T.; Merkel, H.; Vanderhaeghen, M.

    2013-07-01

    Motivated by anomalies in cosmic ray observations and by attempts to solve questions of the Standard Model of particle physics like the (g-2)μ discrepancy, U(1) extensions of the Standard Model have been proposed in recent years. Such U(1) extensions allow for the interaction of dark matter by exchange of a photonlike massive force carrier γ' not included in the Standard Model. In order to search for γ' bosons, various experimental programs have been started. One approach is the dedicated search at fixed-target experiments at modest energies as performed at microtron (MAMI) or at the Jefferson Lab. In these experiments the process e(A,Z)→e(A,Z)l+l- is investigated, and a search for a very narrow resonance in the invariant mass distribution of the l+l- pair is performed. In this work we analyze this process in terms of signal and background in order to describe existing data obtained by the A1 experiment at MAMI with the aim to give accurate predictions for exclusion limits in the γ' parameter space. We present a detailed theoretical analysis of the cross sections entering in the description of such processes.

  6. Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells

    PubMed Central

    Li, Shu-Jun; Luo, Ying; Zhang, Le-Meng; Yang, Wei; Zhang, Guo-Gang

    2017-01-01

    Hemophilia B occurs due to a deficiency in human blood coagulation factor IX (hFIX). Currently, no effective treatment for hemophilia B has been identified, and gene therapy has been considered the most appropriate treatment. Mesenchymal stem cells (MSCs) have homing abilities and low immunogenicity, and therefore they may be potential cell carriers for targeted drug delivery to lesional tissues. The present study constructed an adeno-associated virus integration site 1 (AAVS1)-targeted vector termed AAVS1-green fluorescent protein (GFP)-hFIX and a zinc finger nuclease (ZFN) expression vector. Nucleofection was used to co-transfect the targeting vector and the ZFN expression vector into human MSCs. The GFP-positive cells were selected using flow cytometry. Site-specific integration clones were obtained following the monoclonal culture, subsequent detections were performed using polymerase chain reaction and Southern blotting. Following the confirmation of stem cell traits of the site-specific integration MSCs, the in vivo and in vitro expression levels of hFIX were detected. The results demonstrated that the hFIX gene was successfully transfected into the AAVS1 locus in human MSCs. The clones with the site-specific integration retained stem cell traits of the MSCs. In addition, hFIX was effectively expressed in vivo and in vitro. No significant differences in expression levels were identified among the individual clones. In conclusion, the present study demonstrated that the exogenous gene hFIX was effectively expressed following site-specific targeting into the AAVS1 locus in MSCs; therefore, MSCs may be used as potential cell carriers for gene therapy of hemophilia B. PMID:28112377

  7. A Novel Fixed-Target Task to Determine Articulatory Speed Constraints in Persons with Amyotrophic Lateral Sclerosis

    ERIC Educational Resources Information Center

    Mefferd, Antje S.; Green, Jordan R.; Pattee, Gary

    2012-01-01

    Purpose: The goal of this study was to determine if talkers with ALS are limited in their ability to increase lower lip and jaw speed at an early stage of the disease when their speaking rate and intelligibility are only minimally or not affected. Method: A novel metronome paced fixed-target task was used to assess movement speed capacities during…

  8. Dilepton and φ meson production in elementary and nuclear collisions at the NICA fixed-target experiment

    NASA Astrophysics Data System (ADS)

    Wolf, György; Zétényi, Miklós

    2016-08-01

    We argue that the NICA fixed-target experiment will be able to provide very important new experimental data on dilepton and φ meson production in the basically undiscovered energy domain between the SIS and SPS energies. Experimental information about elementary cross sections in this energy region is an essential ingredient of models of nuclear collisions in the same energy range.

  9. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) An initial target cost. (ii) An initial target profit. (iii) An initial profit adjustment formula to... target cost and firm target profit will be negotiated (usually before delivery or shop completion of the..., the parties negotiate the firm target cost, giving consideration to cost experience under the...

  10. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor), and... established by applying the formula. When the final cost is less than the target cost, application of the formula results in a final profit greater than the target profit; conversely, when final cost is more...

  11. Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours

    PubMed Central

    Wong, Stephen Q.; Li, Jason; Salemi, Renato; Sheppard, Karen E.; Hongdo Do; Tothill, Richard W.; McArthur, Grant A.; Dobrovic, Alexander

    2013-01-01

    Massively parallel sequencing offers the ability to interrogate a tumour biopsy for multiple mutational changes. For clinical samples, methodologies must enable maximal extraction of available sequence information from formalin-fixed and paraffin-embedded (FFPE) material. We assessed the use of targeted capture for mutation detection in FFPE DNA. The capture probes targeted the coding region of all known kinase genes and selected oncogenes and tumour suppressor genes. Seven melanoma cell lines and matching FFPE xenograft DNAs were sequenced. An informatics pipeline was developed to identify variants and contaminating mouse reads. Concordance of 100% was observed between unfixed and formalin-fixed for reported COSMIC variants including BRAF V600E. mutations in genes not conventionally screened including ERBB4, ATM, STK11 and CDKN2A were readily detected. All regions were adequately covered with independent reads regardless of GC content. This study indicates that hybridisation capture is a robust approach for massively parallel sequencing of FFPE samples. PMID:24336498

  12. An expression of interest in a Super Fixed Target Beauty Facility (SFT) at the Superconducting Super Collider

    SciTech Connect

    Not Available

    1990-05-25

    The concept of a Super Fixed Target Beauty Facility (SFT) which uses a relatively low intensity 20 TeV proton beam as a generator of very high momenta B's is an exciting prospect which is very competitive with other B factory ideas. The yields of B's in such a facility are quite high (3 {times} 10{sup 10} {yields} 10{sup 11} B's per year). At this level of statistics, CP violation measurements will be possible in many modes. In addition, the fixed target configuration, because of the high momenta of the produced B's and the resulting long decay lengths, facilitates the detection and reconstruction of B's and offers unique opportunities for observation of the B decays. The limited solid angle coverage required for the fixed target spectrometer makes the cost of the facility much cheaper than other e{sup +}e{sup {minus}} or hadron collider options under consideration. The relatively low intensity 20 TeV beam (1 {yields} 2 {times} 10{sup 8} protons/second) needed for the SFT makes it possible to consider an extraction system which operates concurrently and in a non-interfering manner with the other collider experiments. One possible method for generating such a beam, crystal channeling, is discussed.

  13. Growing Fixed With Age: Lay Theories of Malleability Are Target Age-Specific.

    PubMed

    Neel, Rebecca; Lassetter, Bethany

    2015-11-01

    Beliefs about whether people can change ("lay theories" of malleability) are known to have wide-ranging effects on social motivation, cognition, and judgment. Yet rather than holding an overarching belief that people can or cannot change, perceivers may hold independent beliefs about whether different people are malleable-that is, lay theories may be target-specific. Seven studies demonstrate that lay theories are target-specific with respect to age: Perceivers hold distinct, uncorrelated lay theories of people at different ages, and younger targets are considered to be more malleable than older targets. Both forms of target-specificity are consequential, as target age-specific lay theories predict policy support for learning-based senior services and the rehabilitation of old and young drug users. The implications of target age-specific lay theories for a number of psychological processes, the social psychology of aging, and theoretical frameworks of malleability beliefs are discussed.

  14. Spin and diffractive physics with a fixed-target experiment at the LHC (AFTER-LHC)

    SciTech Connect

    Lorce, C.; Chambert, V.; Didelez, J. P.; Genolini, B.; Hadjidakis, C.; Lansberg, J. P.; Rosier, P.; Brodsky, S. J.; Ferreiro, E. G.; Fleuret, F.

    2013-04-15

    We report on the spin and diffractive physics at a future multi-purpose f xed-target experiment with proton and lead LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic f xed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER using typical targets would surpass that of RHIC by more than 3 orders of magnitude. The f xed-target mode has the advantage to allow for measurements of single-spin asymmetries with polarized target as well as of single-diffractive processes in the target region.

  15. Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.

    PubMed

    Steiner, Carine; Tille, Jean-Christophe; Lamerz, Jens; Kux van Geijtenbeek, Sabine; McKee, Thomas A; Venturi, Miro; Rubbia-Brandt, Laura; Hochstrasser, Denis; Cutler, Paul; Lescuyer, Pierre; Ducret, Axel

    2015-10-01

    The ability to accurately quantify proteins in formalin-fixed paraffin-embedded tissues using targeted mass spectrometry opens exciting perspectives for biomarker discovery. We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors. Peptide candidates were identified using an untargeted mass spectrometry approach in relevant cell lines. A multiplexed assay was developed for the six best candidate peptides and evaluated for linearity, precision and lower limit of quantification. Results showed a linear response over a calibration range of 0.012 to 100 fmol on column (R(2): 0.99-1.00).The lower limit of quantification was 0.155 fmol on column for all peptides evaluated. The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology. The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues. After normalization for sample size, selected reaction monitoring peptide measurements were able to correctly predict 90% of cases based on HER2 amplification as defined by the American Society of Clinical Oncology and College of American Pathologists. In conclusion, the developed assay showed good analytical performance and a high agreement with immunohistochemistry and fluorescence in situ hybridization data. This study demonstrated that selected reaction monitoring allows to accurately quantify protein expression in formalin-fixed paraffin-embedded tissues and represents therefore a powerful approach for biomarker discovery studies. The untargeted mass spectrometry

  16. Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides.

    PubMed

    Roxin, Áron; Zheng, Gang

    2012-08-01

    Peptides can serve as versatile cancer-targeting ligands and have been used for clinically relevant applications such as cancer imaging and therapy. A current and long-standing focus within peptide research is the creation of structurally constrained peptides generated through cyclization. Cyclization is envisioned to enhance the selective binding, uptake, potency and stability of linear precursors. This review compares closely related linear and cyclic peptides in these respects. Peptide cyclization generally improves the selective binding and stability of linear precursors; however, not all cyclization strategies and constrained geometries enhance these properties to the same extent. In some instances, linear analogues actually have better cancer-targeting properties compared with their cyclic counterparts. Although cyclization does not necessarily improve the cancer-targeting properties of linear analogues, cyclic peptides may obtain properties that allow them to be used for additional applications. This review aims to convey the advantages and limitations of cyclic cancer-targeting peptides.

  17. Arizona Public Library Statistics, 1996-1997.

    ERIC Educational Resources Information Center

    Arizona State Dept. of Library, Archives and Public Records, Phoenix.

    This document is a compilation of information supplied by Arizona public libraries. Data is arranged by a separate index divider for each of these county groups: Apache, Cochise, and Coconino; Gila, Graham, Greenlee, and La Paz; Maricopa and Mohave; Navajo, Pima, and Pinal; and Santa Cruz, Yavapai, and Yuma. Each section contains tables of the…

  18. ACT Assessment 1996-1997: User Handbook.

    ERIC Educational Resources Information Center

    American Coll. Testing Program, Iowa City, IA.

    The ACT Assessment is a measure of skills in English, mathematics, reading, and science reasoning necessary for college coursework. This booklet includes four sections designed to help the assessment user. Section 1, "Components of the ACT Assessment," contains general information about the assessment for counselors and college advisors…

  19. Center for beam physics 1996-1997

    SciTech Connect

    1997-02-01

    The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center`s program include addressing R&D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R&D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R&D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP`s outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997.

  20. Voices for Illinois Children, 1996-1997.

    ERIC Educational Resources Information Center

    Voices for Illinois Children, 1997

    1997-01-01

    These newsletters are produced by Voices for Illinois Children, a child advocacy group that works to make kids "count" in Illinois and to ensure that the basic needs of all children, families, and communities are met. The spring 1996 issue provides membership information and network news, as well as articles addressing the following…

  1. Literacy across the Curriculum, 1996-1997.

    ERIC Educational Resources Information Center

    Shohet, Linda, Ed.

    1997-01-01

    This volume consists of four issues. Issue 1 looks at some recent research on practice and is composed of these articles: "Reflection on Literacy," a summary of the World Conference on Literacy; "How Effective Is Adult Literacy Education?" that reports outcomes of Ontario Literacy Coalition studies; "UK Trends: Assessing…

  2. Summary of Research. 1996-1997

    DTIC Science & Technology

    1997-10-01

    deconstructionist, and historicist approaches to the texts which survive and concludes that an archaeological method modeled on Foucault offers the most...and Trident Scholar Mark Skubis, as well as French her model has been formally requested and supplied nationals Sylvestre Maurice and Michel Blanc

  3. HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

    PubMed

    Moens, Lotte N J; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; Sundström, Magnus; La Fleur, Linnéa; Mathot, Lucy; Micke, Patrick; Nilsson, Mats; Botling, Johan

    2015-11-01

    In recent years, the advent of massively parallel next-generation sequencing technologies has enabled substantial advances in the study of human diseases. Combined with targeted DNA enrichment methods, high sequence coverage can be obtained for different genes simultaneously at a reduced cost per sample, creating unique opportunities for clinical cancer diagnostics. However, the formalin-fixed, paraffin-embedded (FFPE) process of tissue samples, routinely used in pathology departments, results in DNA fragmentation and nucleotide modifications that introduce a number of technical challenges for downstream biomolecular analyses. We evaluated the HaloPlex target enrichment system for somatic mutation detection in 80 tissue fractions derived from 20 clinical cancer cases with paired tumor and normal tissue available in both FFPE and fresh-frozen format. Several modifications to the standard method were introduced, including a reduced target fragment length and two strand capturing. We found that FFPE material can be used for HaloPlex-based target enrichment and next-generation sequencing, even when starting from small amounts of DNA. By specifically capturing both strands for each target fragment, we were able to reduce the number of false-positive errors caused by FFPE-induced artifacts and lower the detection limit for somatic mutations. We believe that the HaloPlex method presented here will be broadly applicable as a tool for somatic mutation detection in clinical cancer settings.

  4. A framework to analyze searches for gauge bosons of the hidden light sector in electron scattering fixed target experiments

    SciTech Connect

    Beranek, T.

    2013-11-07

    Electron scattering fixed target experiments are a versatile tool to probe various kinds of physics phenomena. Recently fixed target experiments in which an electron beam is scattered off a heavy nucleus and a lepton-antilepton pair is created, i.e. e(A,Z) →e(A,Z)l{sup +}l{sup −}, were utilized to search for physics beyond the standard model at modest energies. In these experiments one searches for a small, narrow resonance in the invariant mass spectrum of the lepton-antilepton pair, arising from the exchange of a new light gauge boson γ′ coupling to the dark sector as well as very weakly to standard model particles. Such a signal would appear as an enhancement over a smooth QED background. Hence a precise understanding of the background is crucial. We present a theoretical analysis of the process e(A,Z) →e(A,Z)l{sup +}l{sup −}. Therefore we have performed an analysis of the cross section, which is then used to extract exclusion limits on the parameter space of the γ′, describing the existing experimental data taken at MAMI.

  5. Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues*

    PubMed Central

    Steiner, Carine; Tille, Jean-Christophe; Lamerz, Jens; Kux van Geijtenbeek, Sabine; McKee, Thomas A.; Venturi, Miro; Rubbia-Brandt, Laura; Hochstrasser, Denis; Cutler, Paul; Lescuyer, Pierre; Ducret, Axel

    2015-01-01

    The ability to accurately quantify proteins in formalin-fixed paraffin-embedded tissues using targeted mass spectrometry opens exciting perspectives for biomarker discovery. We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors. Peptide candidates were identified using an untargeted mass spectrometry approach in relevant cell lines. A multiplexed assay was developed for the six best candidate peptides and evaluated for linearity, precision and lower limit of quantification. Results showed a linear response over a calibration range of 0.012 to 100 fmol on column (R2: 0.99–1.00).The lower limit of quantification was 0.155 fmol on column for all peptides evaluated. The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology. The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues. After normalization for sample size, selected reaction monitoring peptide measurements were able to correctly predict 90% of cases based on HER2 amplification as defined by the American Society of Clinical Oncology and College of American Pathologists. In conclusion, the developed assay showed good analytical performance and a high agreement with immunohistochemistry and fluorescence in situ hybridization data. This study demonstrated that selected reaction monitoring allows to accurately quantify protein expression in formalin-fixed paraffin-embedded tissues and represents therefore a powerful approach for biomarker discovery studies. The untargeted mass spectrometry

  6. The CO2 stimulus for cerebrovascular reactivity: Fixing inspired concentrations vs. targeting end-tidal partial pressures.

    PubMed

    Fisher, Joseph A

    2016-06-01

    Cerebrovascular reactivity (CVR) studies have elucidated the physiology and pathophysiology of cerebral blood flow regulation. A non-invasive, high spatial resolution approach uses carbon dioxide (CO2) as the vasoactive stimulus and magnetic resonance techniques to estimate the cerebral blood flow response. CVR is assessed as the ratio response change to stimulus change. Precise control of the stimulus is sought to minimize CVR variability between tests, and show functional differences. Computerized methods targeting end-tidal CO2 partial pressures are precise, but expensive. Simpler, improvised methods that fix the inspired CO2 concentrations have been recommended as less expensive, and so more widely accessible. However, these methods have drawbacks that have not been previously presented by those that advocate their use, or those that employ them in their studies. As one of the developers of a computerized method, I provide my perspective on the trade-offs between these two methods. The main concern is that declaring the precision of fixed inspired concentration of CO2 is misleading: it does not, as implied, translate to precise control of the actual vasoactive stimulus - the arterial partial pressure of CO2 The inherent test-to-test, and therefore subject-to-subject variability, precludes clinical application of findings. Moreover, improvised methods imply widespread duplication of development, assembly time and costs, yet lack uniformity and quality control. A tabular comparison between approaches is provided.

  7. Studies of the LBL CMOS integrated amplifier/discriminator for randomly timed inputs from fixed target experiments

    SciTech Connect

    Russ, J.S.; Yarema, R.J.; Zimmerman, T.

    1988-12-01

    A group at Lawrence Berkeley Laboratory has reported an elegant CMOS VLSI circuit for amplifying, discriminating, and encoding the signals from highly-segmented charge output devices, e.g., silicon strip detectors or pad readout structures in gaseous detectors. The design exploits switched capacitor circuits and the well-known time structure of data acquisition in colliding beam accelerators to cancel leakage effects and switching noise. For random inputs, these methods are not directly applicable. However, the high speed of the reset switches makes possible a mode of operation for fixed target experiments that uses fast resets to erase unwanted data from random triggers. Data acquisition in this mode has been performed. Details of operation and measurements of noise and rate capability will be presented. 8 refs., 6 figs.

  8. Performance of the SLC polarized electron source and injector with the SLAC 3 km linac configured for fixed target experiments

    SciTech Connect

    Yeremian, A.D.; Alley, R.K.; Clendenin, J.E.

    1993-03-01

    The SLC polarized electron source (PES) can be modified to produce {mu}sec-long pulses for injection into the un-SLEDed SLAC 3 km linac, with a duty factor considerably higher than for SLC. Such beams are desirable for fixed target experiments at SLAC requiring polarized electron beams of up to 50 mA within an energy spread of 0.5%, at energies of up to 26 GeV. During the fall of 1992, the SLAC linac was operated continuously for two months unSLEDed with the PES dye laser (715 nm) modified to produce a 1{mu}ec pulse at 120Hz. An AlGaAs photocathode was installed in the electron gun to achieve 40% polarization, and a prebuncher was added to the SLC injector to improve capture for long pulse beams. We discuss the performance eo the polarized electron beam for long pulse operation.

  9. The muon component in extensive air showers and new p+C data in fixed target experiments

    SciTech Connect

    Meurer, C.; Bluemer, J.; Engel, R.; Haungs, A.; Roth, M.

    2007-03-19

    One of the most promising approaches to determine the energy spectrum and composition of the cosmic rays with energies above 1015 eV is the measurement of the number of electrons and muons produced in extensive air showers (EAS). Therefore simulation of air showers using electromagnetic and hadronic interaction models are necessary. These simulations show uncertainties which come mainly from hadronic interaction models. One aim of this work is to specify the low energy hadronic interactions which are important for the muon production in EAS. Therefore we simulate extensive air showers with a modified version of the simulation package CORSIKA. In particular we investigate in detail the energy and the phase space regions of secondary particle production, which are most important for muon production. This phase space region is covered by fixed target experiments at CERN. In the second part of this work we present preliminary momentum spectra of secondary {pi}+ and {pi}- in p+C collisions at 12 GeV/c measured with the HARP spectrometer at the PS accelerator at CERN. In addition we use the new p+C NA49 data at 158 GeV/c to check the reliability of hadronic interaction models for muon production in EAS. Finally, possibilities to measure relevant quantities of hadron production in existing and planned accelerator experiments are discussed.

  10. Effects of azimuth-symmetric acceptance cutoffs on the measured asymmetry in unpolarized Drell-Yan fixed-target experiments

    NASA Astrophysics Data System (ADS)

    Bianconi, A.; Bussa, M. P.; Destefanis, M.; Ferrero, L.; Greco, M.; Maggiora, M.; Spataro, S.

    2013-04-01

    Fixed-target unpolarized Drell-Yan experiments often feature an acceptance depending on the polar angle of the lepton tracks in the laboratory frame. Typically leptons are detected in a defined angular range, with a dead zone in the forward region. If the cutoffs imposed by the angular acceptance are independent of the azimuth, at first sight they do not appear dangerous for a measurement of the cos(2 φ) asymmetry, which is relevant because of its association with the violation of the Lam-Tung rule and with the Boer-Mulders function. On the contrary, direct simulations show that up to 10 percent asymmetries are produced by these cutoffs. These artificial asymmetries present qualitative features that allow them to mimic the physical ones. They introduce some model dependence in the measurements of the cos(2 φ) asymmetry, since a precise reconstruction of the acceptance in the Collins-Soper frame requires a Monte Carlo simulation, that in turn requires some detailed physical input to generate event distributions. Although experiments in the eighties seem to have been aware of this problem, the possibility of using the Boer-Mulders function as an input parameter in the extraction of transversity has much increased the requirements of precision on this measurement. Our simulations show that the safest approach to these measurements is a strong cutoff on the Collins-Soper polar angle. This reduces statistics, but does not necessarily decrease the precision in a measurement of the Boer-Mulders function.

  11. Single-Transverse-Spin-Asymmetry studies with a fixed-target experiment using the LHC beams (AFTER@LHC)

    DOE PAGES

    Lansberg, J. P.; Anselmino, M.; Arnaldi, R.; ...

    2016-11-19

    Here we discuss the potential of AFTER@LHC to measure single-transverse-spin asymmetries in open-charm and bottomonium production. With a HERMES-like hydrogen polarised target, such measurements over a year can reach precisions close to the per cent level. This is particularly remarkable since these analyses can probably not be carried out anywhere else.

  12. New prospects in fixed target searches for dark forces with the SeaQuest experiment at Fermilab

    DOE PAGES

    Gardner, S.; Holt, R. J.; Tadepalli, A. S.

    2016-06-10

    An intense 120 GeV proton beam incident on an extremely long iron target generates enormous numbers of light-mass particles that also decay within that target. If one of these particles decays to a final state with a hidden gauge boson, or if such a particle is produced as a result of the initial collision, then that weakly interacting hidden-sector particle may traverse the remainder of the target and be detected downstream through its possible decay to an e+e–, μ+μ–, or π+π– final state. These conditions can be realized through an extension of the SeaQuest experiment at Fermilab, and in thismore » initial investigation we consider how it can serve as an ultrasensitive probe of hidden vector gauge forces, both Abelian and non-Abelian. Here a light, weakly coupled hidden sector may well explain the dark matter established through astrophysical observations, and the proposed search can provide tangible evidence for its existence—or, alternatively, constrain a “sea” of possibilities.« less

  13. New prospects in fixed target searches for dark forces with the SeaQuest experiment at Fermilab

    SciTech Connect

    Gardner, S.; Holt, R. J.; Tadepalli, A. S.

    2016-06-10

    An intense 120 GeV proton beam incident on an extremely long iron target generates enormous numbers of light-mass particles that also decay within that target. If one of these particles decays to a final state with a hidden gauge boson, or if such a particle is produced as a result of the initial collision, then that weakly interacting hidden-sector particle may traverse the remainder of the target and be detected downstream through its possible decay to an e+e, μ+μ, or π+π final state. These conditions can be realized through an extension of the SeaQuest experiment at Fermilab, and in this initial investigation we consider how it can serve as an ultrasensitive probe of hidden vector gauge forces, both Abelian and non-Abelian. Here a light, weakly coupled hidden sector may well explain the dark matter established through astrophysical observations, and the proposed search can provide tangible evidence for its existence—or, alternatively, constrain a “sea” of possibilities.

  14. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

    SciTech Connect

    Sherrell, Darren A.; Foster, Andrew J.; Hudson, Lee; Nutter, Brian; O'Hea, James; Nelson, Silke; Pare-Labrosse, Olivier; Oghbaey, Saeed; Miller, R. J. Dwayne; Owen, Robin L.

    2015-01-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.

  15. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

    DOE PAGES

    Sherrell, Darren A.; Foster, Andrew J.; Hudson, Lee; ...

    2015-01-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with themore » stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.« less

  16. The data acquisition system for a fixed target experiment at NICA complex at JINR and its connection to the ATLAS TileCal readout electronics

    NASA Astrophysics Data System (ADS)

    Tomiwa, K. G.; Slepnev, I.; Bazylev, S.

    2015-10-01

    Today's large-scale science projects have always encountered challenges in processing large data flow from the experiments, the ATLAS detector records proton-proton collisions provided by the Large Hadron Collider (LHC) at CERN every 50 ns which results in a total data flow of 10 Pb/s. These data must be reduced to the science data product for further analysis, thus a very fast decisions need to be executed, to modify this large amounts of data at high rates. The capabilities required to support this scale of data movement is development and improvement of high-throughput electronics. The upgraded LHC will provide collisions at rates that will be at least 10 times higher than those of today due to it's luminosity by 2022. This will require a complete redesign of the read-out electronics and Processing Units (PU) in the Tile-calorimeter (TileCal) of the ATLAS experiment. A general purpose, high-throughput PU has been developed for the TileCal at CERN, by using several ARM-processors in cluster configuration. The PU is capable of handling large data throughput and apply advanced operations at high rates. This system has been proposed for the fixed target experiment at NICA complex to handle the first level processes and event building. The aim of this work is to have a look at the architecture of the data acquisition system (DAQ) of the fixed target experiment at the NICA complex at JINR, by compiling the data-flow requirements of all the subcomponents. Furthermore, the VME DAQ modules characteristics to control, triggering and data acquisition will be described in order to define the DAQ with maximum readout efficiency, no dead time and data selection and compression.

  17. An electron fixed target experiment to search for a new vector boson A' decaying to e+e-

    DOE PAGES

    Rouven Essig; Schuster, Philip; Toro, Natalia; ...

    2011-02-02

    We describe an experiment to search for a new vector boson A' with weak coupling alpha' > 6 x 10–8 α to electrons (α' = e2/4π) in the mass range 65 MeV < mA' < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the "dark photon" A' with the photon -- one of the very few ways in which new forces can couple to the Standard Model -- and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiation off an electronmore » beam, and could appear as narrow resonances with small production cross-section in the trident e+e- spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of ~1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e+e- pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a ~1 month run, APEX will achieve very good sensitivity because the statistics of e+e- pairs will be ~10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to α'/α one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.« less

  18. An Electron Fixed Target Experiment to Search for a New Vector Boson A' Decaying to e+e-

    SciTech Connect

    Essig, Rouven; Schuster, Philip; Toro, Natalia; Wojtsekhowski, Bogdan; /Jefferson Lab

    2010-06-11

    We describe an experiment to search for a new vector boson A' with weak coupling {alpha}' {approx}> 6 x 10{sup -8} {alpha} to electrons ({alpha} = e{sup 2}/4{pi}) in the mass range 65 MeV < m{sub A'} < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the 'dark photon' A' with the photon - one of the very few ways in which new forces can couple to the Standard Model - and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiation off an electron beam, and could appear as narrow resonances with small production cross-section in the trident e{sup +}e{sup -} spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of {approx} 1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e{sup +}e{sup -} pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a {approx} 1 month run, APEX will achieve very good sensitivity because the statistics of e{sup +}e{sup -} pairs will be {approx} 10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to {alpha}'/{alpha} one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.

  19. Working Papers in Educational Linguistics, 1996-1997.

    ERIC Educational Resources Information Center

    Furumoto, Mitchell A., Ed.; And Others

    1997-01-01

    Reports of language research in the 1996 issue include: "Corpus Planning for the Southern Peruvian Quechua Language" (Serafin M. Coronel-Molina); "Foreign Language Planning in U.S. Higher Education: The Case of a Graduate Business Program" (Mitchell A. Furumoto); "Charting New Directions: Of Communication in a Social…

  20. AGS experiments -- 1996, 1997, 1998, 1999. Fifteenth edition

    SciTech Connect

    Lo Presti, P.

    1999-03-01

    This report is a compilation of two-page summaries for AGS experiments for FY 1996, FY 1997, FY 1998, FY 1999. The bulk of the experiments are for high energy physics and nuclear physics programs. Also included are the run schedules for the AGS for each of those years and a listing of publications of AGS experiments for 1982--1999.

  1. Assessment Program Technical Progress Report, 1996-1997.

    ERIC Educational Resources Information Center

    McCown, Laurie; Fanning, Erin; Eickmeyer, Barbara

    Coconino Community College (CCC) annually assesses its institutional effectiveness to demonstrate its commitment to improving programs and services to students. The 1996-97 Assessment Program Technical Progress Report records the assessment and institutional activities enacted during the academic year, detailing the assessment model, timelines,…

  2. Distillate Fuel Oil Assessment for Winter 1996-1997

    EIA Publications

    1997-01-01

    This article describes findings of an analysis of the current low level of distillate stocks which are available to help meet the demand for heating fuel this winter, and presents a summary of the Energy Information Administration's distillate fuel oil outlook for the current heating season under two weather scenarios.

  3. Statistical Summary of Missouri Higher Education, 1996-1997.

    ERIC Educational Resources Information Center

    Missouri Coordinating Board for Higher Education, Jefferson City.

    Extensive data tables on higher education in Missouri present information on: the academic preparation of college freshmen (fall 1996), including distribution of American College Testing (ACT) scores and high school rankings; tuition, fees, and financial aid (state and federal, by aid type, including merit-based scholarships) and trends;…

  4. Health sciences library building projects, 1996-1997 survey.

    PubMed Central

    Bowden, V M

    1998-01-01

    Nine building projects are briefly described, including four new libraries, two renovations, and three combined renovations and additions. The libraries range in size from 657 square feet to 136,832 square feet, with seating varying from 14 to 635. Three hospital libraries and four academic health sciences libraries are described in more detail. In each case an important consideration was the provision for computer access. Two of the libraries expanded their space for historical collections. Three of the libraries added mobile shelving as a way of storing print materials while providing space for other activities. Images PMID:9549012

  5. Foundation for Child Development (FCD) Annual Report, 1996/1997.

    ERIC Educational Resources Information Center

    Foundation for Child Development, New York, NY.

    This annual report details the 1996-97 activities of the Foundation for Child Development. Included in the report is a discussion of the history and mission of the foundation and its funding priorities. The members of the Council, Board of Directors, Officers, and staff are listed. The report of the chair, Barbara Paul Robinson, describes the…

  6. 1996-1997 TEMA/DOE oversite annual report

    SciTech Connect

    1998-01-01

    The Tennessee Emergency Management Agency (TEMA) has entered into a five-year agreement with the Department of Energy (DOE) to provide emergency response activities associated with the Oak Ridge Reservation (ORR). The Agreement in Principle (AIP) delineates the duties and responsibilities of the parties. The agreement tasked TEMA with the following responsibilities: develop offsite emergency plans; conduct emergency management training; develop offsite emergency organizations; develop emergency communications; develop emergency facilities; conduct exercises and drills; provide detection and protection equipment; and develop an emergency staff. This document reports on progress on these tasks during the past year.

  7. 1996--1997 TEMA/DOE oversight annual report

    SciTech Connect

    1998-06-01

    The Tennessee Emergency Management Agency (TEMA) has entered into a five-year agreement with the Department of Energy (DOE) to provide emergency response activities associated with the Oak Ridge Reservation (ORR). The Agreement in Principle (AIP) delineates the duties and responsibilities of the parties. The agreement tasked TEMA with the following responsibilities: develop offsite emergency plans; conduct emergency management training; develop offsite emergency organizations; develop emergency communications; develop emergency facilities; conduct exercises and drills; provide detection and protection equipment; and develop an emergency staff. This report describes progress on the 14 deliverables connected with this contract.

  8. Working Papers in Art Education, 1996-1997.

    ERIC Educational Resources Information Center

    Thunder-McGuire, Steve

    1997-01-01

    This collection of working papers in art education is comprised of manuscripts by graduate students presented at the National Art Education Conference. Papers in this issue reflect several educational settings and geographic areas. The 22 articles include: (1) "Symbolic Meanings in the Ghanaian Arts: A Step Towards Developing Cultural Literacy"…

  9. Genetic Issues in Mental Retardation, 1996-1997.

    ERIC Educational Resources Information Center

    Genetic Issues in Mental Retardation, 1996

    1996-01-01

    This document consists of the first six issues of a newsletter, which discusses current knowledge about and concerns related to genetics and mental retardation. The second issue addresses the problem of genetic discrimination. The third issue considers genetic testing, screening, and counseling. The fourth issue addresses genetic privacy issues.…

  10. Early Childhood Review: Papers from GAEC, 1996-1997.

    ERIC Educational Resources Information Center

    Cartwright, Penny, Ed.; Kelly, Clare, Ed.; McLean, Kathy, Ed.; Mellor, Nikki, Ed.; Pidgeon, Sue, Ed.; Stevens, Judith, Ed.; Stables, Kay, Ed.

    1996-01-01

    This periodical, from Goldsmiths Association for Early Childhood (GAEC), addresses a variety of issues related to early childhood education in Great Britain. Articles included in the Spring 1996 issue are: (1) "Traditional Story Telling in the Early Years" (Fiona Collins); (2) "International Focus--Early Childhood Education…

  11. Fixed solar collection system

    SciTech Connect

    Tipton, H.R.

    1984-07-31

    A fixed solar energy collector system has facing panels of different size forming a Vee-shaped trough open at its base and supporting a plurality of highly reflective convex reflectors strategically disposed upon said panels in reflective relationship to a plurality of Fresnel lenses positioned at the base of the trough. A suitable reflector, disposed beneath the Fresnel lenses, directs the reflected energy to a heat-needy target.

  12. Semileptonic and Rare D and Ds Charm Decays at Focus

    NASA Astrophysics Data System (ADS)

    Johns, Will E.

    Over 1 million charm decays were collected by the E831 photoproduction experiment (FOCUS) during the 1996-1997 Fermilab fixed target run. Analysis techniques and results particular to semileptonic and rare D and Ds charm decays from the FOCUS experiment are reviewed.

  13. Exact Green's functions for a Brownian particle reversibly binding to a fixed target in a finite, two-dimensional, circular domain

    NASA Astrophysics Data System (ADS)

    Kalay, Ziya

    2012-06-01

    Despite the apparent need to study reversible reactions between molecules confined to a two-dimensional space such as the cell membrane, exact Green’s functions for this case have not been reported. Here we present exact analytical Green’s functions for a Brownian particle reversibly reacting with a fixed reaction center in a finite two-dimensional circular region with reflecting or absorbing boundaries, considering either a spherically symmetric initial distribution or a particle that is initially bound. We show that Green’s function can be used to predict the effect of measurement uncertainties on the outcome of single-particle/molecule-tracking experiments in which molecular interactions are investigated. Hence, we bridge the gap between previously known solutions in one dimension (Agmon 1984 J. Chem. Phys. 81 2811) and three dimensions (Kim and Shin 1999 Phys. Rev. Lett. 82 1578), and provide an example of how the knowledge of Green’s function can be used to predict experimentally accessible quantities.

  14. The evolution of systolic blood pressure as a strong predictor of cardiovascular risk and the effectiveness of fixed-dose ARB/CCB combinations in lowering levels of this preferential target

    PubMed Central

    Mourad, Jean-Jacques

    2008-01-01

    Elevated blood pressure is an important cardiovascular risk factor. Although targets for both diastolic blood pressure (DBP) and systolic blood pressure (SBP) are defined by current guidelines, DBP has historically taken precedence in hypertension management. However, there is strong evidence that SBP is superior to DBP as a predictor of cardiovascular events. Moreover, achieving control of SBP is assuming greater importance amongst an aging population. In spite of the growing recognition of the importance of SBP in reducing cardiovascular risk and the emphasis by current guidelines on SBP control, a substantial proportion of patients still fail to achieve SBP targets, and SBP control is achieved much less frequently than DBP control. Thus, new approaches to the management of hypertension are required in order to control SBP and minimize cardiovascular risk. Fixed-dose combination (FDC) therapy is an approach that offers the advantages of multiple drug administration and a reduction in regimen complexity that favors compliance. We have reviewed the latest evidence demonstrating the efficacy in targeting SBP of the most recent FDC products; combinations of the calcium channel blocker (CCB), amlodipine, with angiotensin receptor blockers (ARBs), valsartan or olmesartan. In addition, results from studies with new classes of agent are outlined. PMID:19337545

  15. Fixed-point adiabatic quantum search

    NASA Astrophysics Data System (ADS)

    Dalzell, Alexander M.; Yoder, Theodore J.; Chuang, Isaac L.

    2017-01-01

    Fixed-point quantum search algorithms succeed at finding one of M target items among N total items even when the run time of the algorithm is longer than necessary. While the famous Grover's algorithm can search quadratically faster than a classical computer, it lacks the fixed-point property—the fraction of target items must be known precisely to know when to terminate the algorithm. Recently, Yoder, Low, and Chuang [Phys. Rev. Lett. 113, 210501 (2014), 10.1103/PhysRevLett.113.210501] gave an optimal gate-model search algorithm with the fixed-point property. Previously, it had been discovered by Roland and Cerf [Phys. Rev. A 65, 042308 (2002), 10.1103/PhysRevA.65.042308] that an adiabatic quantum algorithm, operating by continuously varying a Hamiltonian, can reproduce the quadratic speedup of gate-model Grover search. We ask, can an adiabatic algorithm also reproduce the fixed-point property? We show that the answer depends on what interpolation schedule is used, so as in the gate model, there are both fixed-point and non-fixed-point versions of adiabatic search, only some of which attain the quadratic quantum speedup. Guided by geometric intuition on the Bloch sphere, we rigorously justify our claims with an explicit upper bound on the error in the adiabatic approximation. We also show that the fixed-point adiabatic search algorithm can be simulated in the gate model with neither loss of the quadratic Grover speedup nor of the fixed-point property. Finally, we discuss natural uses of fixed-point algorithms such as preparation of a relatively prime state and oblivious amplitude amplification.

  16. Final work plan for targeted investigation at Hilton, Kansas.

    SciTech Connect

    LaFreniere, L. M.; Environmental Science Division

    2007-08-28

    This Work Plan outlines the scope of a targeted investigation to update the status of carbon tetrachloride contamination in groundwater associated with grain storage operations at Hilton, Kansas. The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility in Hilton during the 1950s and 1960s. At the time of the CCC/USDA operation in Hilton, grain storage facilities (CCC/USDA and private) were located along the both sides of the former Union Pacific railroad tracks (Figure 1.1). The main grain storage structures were on or near the railroad right-of-way. The proposed targeted investigation, to be conducted by Argonne National Laboratory on the behalf of CCC/USDA, will supplement Argonne's Phase I and Phase II investigations in 1996-1997. The earlier investigations erroneously focused on an area east of the railroad property where the CCC/USDA did not operate, specifically on a private grain storage facility. In addition, the investigation was limited in scope, because access to railroad property was denied (Argonne 1997a,b). The hydrogeologic system at Hilton is potentially complex.

  17. Why to Treat Subjects as Fixed Effects

    ERIC Educational Resources Information Center

    Adelman, James S.; Estes, Zachary

    2015-01-01

    Adelman, Marquis, Sabatos-DeVito, and Estes (2013) collected word naming latencies from 4 participants who read 2,820 words 50 times each. Their recommendation and practice was that R2 targets set for models should take into account subject idiosyncrasies as replicable patterns, equivalent to a subjects-as-fixed-effects assumption. In light of an…

  18. Fixing Dataset Search

    NASA Technical Reports Server (NTRS)

    Lynnes, Chris

    2014-01-01

    Three current search engines are queried for ozone data at the GES DISC. The results range from sub-optimal to counter-intuitive. We propose a method to fix dataset search by implementing a robust relevancy ranking scheme. The relevancy ranking scheme is based on several heuristics culled from more than 20 years of helping users select datasets.

  19. Fixed mount wavefront sensor

    DOEpatents

    Neal, Daniel R.

    2000-01-01

    A rigid mount and method of mounting for a wavefront sensor. A wavefront dissector, such as a lenslet array, is rigidly mounted at a fixed distance relative to an imager, such as a CCD camera, without need for a relay imaging lens therebetween.

  20. Simulation of hydrodynamics, temperature, and dissolved oxygen in Table Rock Lake, Missouri, 1996-1997

    USGS Publications Warehouse

    Green, W. Reed; Galloway, Joel M.; Richards, Joseph M.; Wesolowski, Edwin A.

    2003-01-01

    Outflow from Table Rock Lake and other White River reservoirs support a cold-water trout fishery of substantial economic yield in south-central Missouri and north-central Arkansas. The Missouri Department of Conservation has requested an increase in existing minimum flows through the Table Rock Lake Dam from the U.S. Army Corps of Engineers to increase the quality of fishable waters downstream in Lake Taneycomo. Information is needed to assess the effect of increased minimum flows on temperature and dissolved- oxygen concentrations of reservoir water and the outflow. A two-dimensional, laterally averaged, hydrodynamic, temperature, and dissolved-oxygen model, CE-QUAL-W2, was developed and calibrated for Table Rock Lake, located in Missouri, north of the Arkansas-Missouri State line. The model simulates water-surface elevation, heat transport, and dissolved-oxygen dynamics. The model was developed to assess the effects of proposed increases in minimum flow from about 4.4 cubic meters per second (the existing minimum flow) to 11.3 cubic meters per second (the increased minimum flow). Simulations included assessing the effect of (1) increased minimum flows and (2) increased minimum flows with increased water-surface elevations in Table Rock Lake, on outflow temperatures and dissolved-oxygen concentrations. In both minimum flow scenarios, water temperature appeared to stay the same or increase slightly (less than 0.37 ?C) and dissolved oxygen appeared to decrease slightly (less than 0.78 mg/L) in the outflow during the thermal stratification season. However, differences between the minimum flow scenarios for water temperature and dissolved- oxygen concentration and the calibrated model were similar to the differences between measured and simulated water-column profile values.

  1. [Saskatchewan Fund for environmental problems]. Annual report and financial statements 1996--1997

    SciTech Connect

    1997-12-31

    This gives the annual report of the Fund, established by the Provincial Government in 1989 to replace the well deposit system and to provide the government with a means to address unique oil and gas related environmental problems. The Fund guarantees the proper drilling, completion and abandonment of wells, including surface restoration, and allows the government to respond to a major spill or environmental problem when liability for the problem cannot initially be determined. This report describes the purpose of the Fund, and summarizes its activities. A financial statement is included.

  2. The organization of Jupiter's upper tropospheric temperature structure and its evolution, 1996-1997

    NASA Astrophysics Data System (ADS)

    Fisher, Brendan M.; Orton, Glenn S.; Liu, Junjun; Schneider, Tapio; Ressler, Michael E.; Hoffman, William F.

    2016-12-01

    High signal-to-noise images of Jupiter were made at wavelengths between 13.2 and 22.8 μm in five separate observing runs between 1996 June and 1997 November at the NASA Infrared Telescope Facility. Maps of Jupiter's upper-tropospheric temperatures at pressures of 100 and 400 mbar were made from these images. We use the relatively frequent, well sampled data sets to examine in detail the short-term evolution of the temperature structure. Our 2-6 month sampling periods demonstrate that the longitudinal temperature structures evolve significantly in these short periods and exhibit wave features. Using a three-dimensional general circulation model simulation of Jupiter's upper atmosphere, we show that the thermal structures are consistent with convectively generated Rossby waves that propagate upward from the lower to the upper atmosphere.

  3. Department of Defense Finance and Accounting Service FY 1996/1997 Biennial Budget Estimates, February 1995.

    DTIC Science & Technology

    1995-02-01

    1500 1750 1744 1716 0D0336 DEFENSE BUSINESS MANAGEMENT SYSTEM Development/Modernization 16112 11043 9600 10400 Current Services 29919 31379 28957...29379 Subtotal 46031 42422 38557 39779 Appropriation: CPP 16112 11043 9600 10400 Appropriation: DBOF 29919 31379 28957 29379 H00146 DEFENSE CIVILIAN PAY

  4. Domestic Violence in Alaska among Women Who Delivered a Live Infant during 1996-1997.

    ERIC Educational Resources Information Center

    Perham-Hester, Kathy; Chamberlain, Linda

    1999-01-01

    Over 1,000 Alaskan women experienced domestic abuse during pregnancy in 1996-97. Alaska Native and teenage mothers are at increased risk of experiencing physical abuse before or during pregnancy. Most Alaska mothers do not receive domestic violence screening during prenatal care. Domestic violence training is recommended for prenatal care…

  5. Research and Clinical Center for Child Development Annual Report, 1996-1997, No. 20.

    ERIC Educational Resources Information Center

    Chen, Shing-Jen, Ed.; Furutsuka, Takashi, Ed.; Shirotani, Yukari

    This annual report discusses several topics related to the work of the Clinical Center for Child Development at Hokkaido University in Sapporo, Japan. The articles are: (1) "Other's Voice/Own Voice: (Re)production of Other's Voice and Its Apprenticeship in Japanese Young Children" (Shing-Jen Chen); (2) "Intersubjectivity during…

  6. Massachusetts Institute of Technology Security Studies Program Annual Report, 1996-1997

    DTIC Science & Technology

    1997-01-01

    the Leo Szilard Prize from the American Physical Society. In I995, he received the Hilliard Roderick Prize from the American Association for the...Lieutenant Colonel Leo Florick, "’Low Yield’ Nuclear Experiments: Should They Be Permitted Within a Comprehensive Test Ban Treaty?," SSP Working Paper

  7. Service-Learning Faculty Manual, Century Community and Technical College, 1996-1997. Revised December 1996.

    ERIC Educational Resources Information Center

    Century Community and Technical Coll., White Bear Lake, MN.

    Prepared to help faculty implement service learning at Minnesota's Century Community and Technical College, this manual reviews service learning and provides strategies for developing components. The first part defines service learning, providing text from the National and Community Service Trust Act of 1993. Next, sample service learning projects…

  8. Learning Languages: The Journal of the National Network for Early Language Learning, 1996-1997.

    ERIC Educational Resources Information Center

    Learning Languages: The Journal of the National Network for Early Language Learning, 1997

    1997-01-01

    This document consists of the three issues of the journal "Learning Languages" published during volume year 2. These issues contain the following major articles: "Minneapolis and Brittany: Children Bridge Geographical and Social Differences Through Technology" (Janine Onffroy Shelley); "Student Reasons for Studying…

  9. Imagine...Opportunities and Resources for Academically Talented Youth, 1996-1997.

    ERIC Educational Resources Information Center

    Hellerman, Susan B., Ed.

    1996-01-01

    This document consists of the five consecutive issues of the journal "Imagine..." published during volume year 4. Typical journal articles cover teaching academically talented secondary students in the following focus areas: (1) planning ahead for college; (2) history and archaeology; (3) physics and astronomy; (4) the global society; and (5)…

  10. Research on Spoken Language Processing. Progress Report No. 21 (1996-1997).

    ERIC Educational Resources Information Center

    Pisoni, David B.

    This 21st annual progress report summarizes research activities on speech perception and spoken language processing carried out in the Speech Research Laboratory, Department of Psychology, Indiana University in Bloomington. As with previous reports, the goal is to summarize accomplishments during 1996 and 1997 and make them readily available. Some…

  11. Trenholm State (AL) Technical College High School Science Enrichment Program 1996-1997 Evaluation Report

    NASA Technical Reports Server (NTRS)

    Ross, Elizabeth G.

    1997-01-01

    This document presents findings based on a third-year evaluation of Trenholm State (AL) Technical College's National Aeronautics and Space Administration (NASA) - supported High School Science Enrichment Program (HSSEP). HSSEP is an external (to school) program for area students from groups that are underrepresented in the mathematics, science, engineering and technology (MSET) professions. In addition to gaining insight into scientific careers, HSSEP participants learn about and deliver presentations that focus on mathematics applications, scientific problem-solving and computer programming during a seven-week summer or 10-week Academic-Year Saturday session.

  12. Atmospheric transport of pesticides in the Sacramento, California, metropolitan area, 1996-1997

    USGS Publications Warehouse

    Majewski, Michael S.; Baston, David S.

    2002-01-01

    Weekly composite, bulk air was sampled with respect to wind speed and direction from January 1996 through December 1997 in one urban and two agricultural locations in Sacramento County, California. The sampling sites were located along a north-south transect, the dominant directions of the prevailing winds. The samples were analyzed for a variety of current-use pesticides, including dormant orchard spray insecticides and rice herbicides. A variety of pesticides were detected throughout the year, predominantly chlorpyrifos, diazinon, and trifluralin. The data obtained during the winter and spring suggest that some pesticides used in agricultural areas become airborne and may be transported into the urban area. Confirmation of this drift is difficult, however, because these three predominant pesticides, as well as other detected pesticides, also are heavily used in the urban environment. The spring data clearly show that molinate and thiobencarb, two herbicides used only in rice production, do drift into the urban environment.

  13. Intercom: Newsletter of the Learning Resources Association of the California Community Colleges, 1996-1997.

    ERIC Educational Resources Information Center

    Naumer, Jan, Ed.

    1997-01-01

    This newsletter provides current information on the state of learning resources centers and libraries in California community colleges. The October 1996 issue provides the LRACCC's annual report for 1995-96, describing the Association's membership, publications, budget, and activities for the year. This issue also includes newsbriefs from 12…

  14. Metals transport in the Sacramento River, California, 1996-1997; Volume 1, Methods and data

    USGS Publications Warehouse

    Alpers, Charles N.; Taylor, Howard E.; Domagalski, Joseph L.

    2000-01-01

    Metals transport in the Sacramento River, northern California, was evaluated on the basis of samples of water, suspended colloids, streambed sediment, and caddisfly larvae that were collected on one to six occasions at 19 sites in the Sacramento River Basin from July 1996 to June 1997. Four of the sampling periods (July, September, and November 1996; and May-June 1997) took place during relatively low-flow conditions and two sampling periods (December 1996 and January 1997) took place during high-flow and flooding conditions; respectively. Tangential-flow ultrafiltration with 10,000 nominal molecular weight limit, or daltons (0.005 micrometer equivalent), pore-size membranes was used to separate metals in streamwater into ultrafiltrate (operationally defined dissolved fraction) and retentate (colloidal fraction) components, respectively. Conventional filtration with capsule filters (0.45 micrometer pore-size) and membrane filters (0.40 micrometer pore-size) and total-recoverable analysis of unfiltered (whole-body) samples were done for comparison at all sites. Because the total-recoverable analysis involves an incomplete digestion of particulate matter, a more reliable measurement of whole-water concentrations is derived from the sum of the dissolved component that is based on the ultrafiltrate plus the suspended component that is based on a total digestion of colloid concentrates from the ultra-filtration retentate. Metals in caddisfly larvae were determined for whole-body samples and cytosol extracts, which are intercellular solutions that provide a more sensitive indication of the metals that have been bioaccumulated. Trace metals in acidic, metal-rich drainage from abandoned and inactive sulfide mines were observed to enter the Sacramento River system (specifically, into both Shasta Lake and Keswick Reservoir) in predominantly dissolved form, as operationally defined using ultrafiltrates. The predominant source of acid mine drainage to Keswick Reservoir is Spring Creek, which drains the Iron Mountain mine area. Copper concentrations in filtered samples from Spring Creek taken during December 1996, January 1997, and May 1997 ranged from 420 to 560 micrograms per liter. Below Keswick Dam, copper concentrations in conventionally filtered samples ranged from 0.5 micrograms per liter during September 1996 to 9.4 micrograms per liter during January 1997; the latter concentration exceeded the applicable water-quality standard. The proportion of trace metals that was dissolved (versus colloidal) in samples collected at Shasta and Keswick dams decreased in the order cadmium zinc > copper > aluminum iron lead mercury. At four sampling sites on the Sacramento River at various distances downstream of Keswick Dam (Bend Bridge, 71 kilometers; Colusa, 256 kilometers; Verona, 360 kilometers; and Freeport, 412 kilometers) concentrations of these seven metals were predominantly colloidal during both high- and low-flow conditions. Because copper compounds are used extensively as algaecides in rice farming, agricultural drainage at the Colusa Basin Drain was sampled in June 1997 during a period shortly after copper applications to newly planted rice fields. Copper concentrations ranged from 1.3 to 3.0 micrograms per liter in filtered samples and from 12 to 13 micrograms per liter in whole-water samples (total recoverable analysis). These results are consistent with earlier work by the U.S. Geological Survey indicating that copper in rice-field drainage likely represents a detectable, but relatively minor source of copper to the Sacramento River. Lead isotope data from suspended colloids and streambed sediments collected during October and November 1996 indicate that lead from acid mine drainage sources became a relatively minor component of the total lead at the site located 71 kilometers downstream of Keswick Dam and beyond. Cadmium, copper, and zinc concentrations in caddisfly larvae were elevated at several sites downstream of Keswick Dam,

  15. Metals transport in the Sacramento River, California, 1996-1997; Volume 2, Interpretation of metal loads

    USGS Publications Warehouse

    Alpers, Charles N.; Antweiler, Ronald C.; Taylor, Howard E.; Dileanis, Peter D.; Domagalski, Joseph L.

    2000-01-01

    Metals transport in the Sacramento River, northern California, from July 1996 to June 1997 was evaluated in terms of metal loads from samples of water and suspended colloids that were collected on up to six occasions at 13 sites in the Sacramento River Basin. Four of the sampling periods (July, September, and November 1996; and May-June 1997) took place during relatively low-flow conditions and two sampling periods (December 1996 and January 1997) took place during high-flow and flooding conditions, respectively. This study focused primarily on loads of cadmium, copper, lead, and zinc, with secondary emphasis on loads of aluminum, iron, and mercury. Trace metals in acid mine drainage from abandoned and inactive base-metal mines, in the East and West Shasta mining districts, enter the Sacramento River system in predominantly dissolved form into both Shasta Lake and Keswick Reservoir. The proportion of trace metals that was dissolved (as opposed to colloidal) in samples collected at Shasta and Keswick dams decreased in the order zinc ? cadmium > copper > lead. At four sampling sites on the Sacramento River--71, 256, 360, and 412 kilometers downstream of Keswick Dam--trace-metal loads were predominantly colloidal during both high- and low-flow conditions. The proportion of total cadmium, copper, lead, and zinc loads transported to San Francisco Bay and the Sacramento-San Joaquin Delta estuary (referred to as the Bay-Delta) that is associated with mineralized areas was estimated by dividing loads at Keswick Dam by loads 412 kilometers downstream at Freeport and the Yolo Bypass. During moderately high flows in December 1996, mineralization-related total (dissolved + colloidal) trace-metal loads to the Bay-Delta (as a percentage of total loads measured downstream) were cadmium, 87 percent; copper, 35 percent; lead, 10 percent; and zinc, 51 percent. During flood conditions in January 1997 loads were cadmium, 22 percent; copper, 11 percent; lead, 2 percent; and zinc, 15 percent. During irrigation drainage season from rice fields (May-June 1997) loads were cadmium, 53 percent; copper, 42 percent; lead, 20 percent; and zinc, 75 percent. These estimates must be qualified by the following factors: (1) metal loads at Colusa in December 1996 and at Verona in May-June 1997 generally exceeded those determined at Freeport during those sampling periods. Therefore, the above percentages represent maximum estimates of the apparent total proportion of metals from mineralized areas upstream of Keswick Dam; and (2) for logistics reasons, the Sacramento River was sampled at Tower Bridge instead of at Freeport during January 1997. Available data suggest that trace metal loads from agricultural drainage may be significant during certain flow conditions in areas where metals such as copper and zinc are added as agricultural amendments. Copper loads for sampling periods in July and September 1996 and in May-June 1997 show increases of dissolved and colloidal copper and in colloidal zinc between Colusa and Verona, the reach of the Sacramento River along which the Colusa Basin Drain, the Sacramento Slough, and other agricultural return flows are tributaries. Monthly sampling of these two agricultural drains by the USGS National Water-Quality Assessment Program shows seasonal variations in metal concentrations, reaching maximum concentrations of 4 to 6 micrograms per liter in 'dissolved' (0.45-micrometer filtrate) copper concentrations in May 1996, December 1996, and June 1997. The total (dissolved plus colloidal) load of copper from the Colusa Basin Drain in June 1997 was 18 kilograms per day, whereas the copper load in Spring Creek, which drains the inactive mines on Iron Mountain, was 20 kilograms per day during the same sampling period. For comparison, during the January 1997 flood, the copper load in Spring Creek was about 1,100 kilograms per day and the copper load in the Yolo Bypass was about 7,300 kilograms per day. The data clearly indicate that mo

  16. Lake Pend Oreille Fishery Recovery Project, 1996-1997 Annual Report.

    SciTech Connect

    Maiolie, Melo A.; Harryman, Bill; Elam, Steve

    1999-09-01

    During the winter of 1996-97, the elevation of Lake Pend Oreille was kept 1.2 m higher in an attempt to recover the impacted Kokanee fishery. This was the first winter of the scheduled three-year test. We found that kokanee spawned on the newly inundated gravels provided by the higher water levels. Many of the redds were at depths of 0.5 to 2 m with the highest density of redds at the 1.2 m depth. We also found the numbers of kokanee spawning in tributary streams declined sharply with the higher lake levels. Presumably, these fish spawned on the lakeshore because of the abundance of shoreline gravel rather than migrate up tributary streams. Kokanee spawning sites were mapped around the entire perimeter of the lake. Most spawning occurred at the southern end of the lake; however, kokanee utilized the newly available spawning gravels throughout much of lake's shorelines. Unusually high spring run-off in 1997 produced an inflow to the lake of 4,360 m{sup 3}/s and raised the lake 1 m above full pool. We found that all age-classes of kokanee declined sharply between 1996 and 1997. Survival rates of all age-classes were at or near the lowest point on record. The cause of these declines is unknown; possible causes include kokanee emigrating from the lake and mortality of kokanee due to dissolved gases in the northern third of the lake reaching 120% to 130% of saturation. High dissolved gases were caused by the Cabinet Gorge and Noxon dams on the Clark Fork River. Kokanee population declines caused by flooding would have masked any benefits to the population resulting from a higher winter lake level.

  17. DOE Hydropower Program biennial report 1996-1997 (with an updated annotated bibliography)

    SciTech Connect

    Rinehart, B.N.; Francfort, J.E.; Sommers, G.L.; Cada, G.F.; Sale, M.J.

    1997-06-01

    This report, the latest in a series of biennial Hydropower Program reports sponsored by the US Department of Energy, summarizes the research and development and technology transfer activities of fiscal years 1996 and 1997. The report discusses the activities in the six areas of the hydropower program: advanced hydropower turbine systems; environmental research; hydropower research and development; renewable Indian energy resources; resource assessment; and technology transfer. The report also includes an annotated bibliography of reports pertinent to hydropower, written by the staff of the Idaho National Engineering and Environmental Laboratory, Oak Ridge National Laboratory, Federal and state agencies, cities, metropolitan water districts, irrigation companies, and public and independent utilities. Most reports are available from the National Technical Information Service.

  18. Nutrients discharged to the Mississippi River from eastern Iowa watersheds, 1996-1997

    USGS Publications Warehouse

    Becher, Kent D.; Schnoebelen, Douglas J.; Akers, Kimberlee K.

    The introduction of nutrients from chemical fertilizer, animal manure, wastewater, and atmospheric deposition to the eastern Iowa environment creates a large potential for nutrient transport in watersheds. Agriculture constitutes 93 percent of all land use in eastern Iowa. As part of the U.S. Geological Survey National Water Quality Assessment Program, water samples were collected (typically monthly) from six small and six large watersheds in eastern Iowa between March 1996 and September 1997. A Geographic Information System (GIS) was used to determine land use and quantify inputs of nitrogen and phosphorus within the study area. Streamliow from the watersheds is to the Mississippi River. Chemical fertilizer and animal manure account for 92 percent of the estimated total nitrogen and 99.9 percent of the estimated total phosphorus input in the study area. Total nitrogen and total phosphorus loads for 1996 were estimated for nine of the 12 rivers and creeks using a minimum variance unbiased estimator model. A seasonal pattern of concentrations and loads was observed. The greatest concentrations and loads occur in the late spring to early summer in conjunction with row-crop fertilizer applications and spring nmoff and again in the late fall to early winter as vegetation goes into dormancy and additional fertilizer is applied to row-crop fields. The three largest rivers in eastern Iowa transported an estimated total of 79,000 metric tons of total nitrogen and 6,800 metric tons of total phosphorus to the Mississippi River in 1996. The estimated mass of total nitrogen and total phosphorus transported to the Mississippi River represents about 19 percent of all estimated nitrogen and 9 percent of all estimated phosphorus input to the study area.

  19. U.S. LNG imports 1996--1997 should recover from low 1995 levels

    SciTech Connect

    Swain, E.J.

    1997-01-27

    Imports of LNG into the US in 1995 were the lowest since 1988, when 17.5 billion cu ft were imported. Total 1995 LNG imported from Algeria was 17.92 bcf compared to 50.78 in 1994, a decrease of 64.7%. About 72% of imported Algerian LNG was received at the Distrigas Corp. terminal north of Boston. The remaining LNG was received at the Trunkline LNG CO. terminal, Lake Charles, La., which was reopened in December 1989. The dramatic decline in LNG imports over the past 2 years (78%) can largely be attributed to Sonatrach`s multiyear renovation project to restore its LNG plants to their original capacities. This major renovation project has resulted in LNG export curtailments to all of its customers. The paper discusses US terminals, base-load producers, LNG pricing, and exports.

  20. STAR Follow-Up Studies, 1996-1997: The Student/Teacher Achievement Ratio (STAR) Project.

    ERIC Educational Resources Information Center

    Pate-Bain, Helen; Boyd-Zaharias, Jayne; Cain, Van A.; Word, Elizabeth; Binkley, M. Edward

    The Student/Teacher Achievement Ratio (STAR) Project first investigated the effect of small class size on student achievement with over 6,000 Tennessee primary students in 1985 through 1989. The study found a consistent and significant benefit of small classes for all students, with the greatest advantages for minority, inner-city students from…

  1. Representative American Speeches 1996-1997. The Reference Shelf Volume 69 Number 6.

    ERIC Educational Resources Information Center

    Logue, Calvin McLeod, Ed.; DeHart, Jean, Ed.

    This collection of representative speeches delivered by public officials and other prominent persons contains addresses to both large and small organizations, given both on ceremonial occasions and on less formal occasions. The collection contains school commencement addresses, addresses to government bodies, speeches to international…

  2. Comprehensive Assessment of the Regulons Controlled by the FixLJ-FixK2-FixK1 Cascade in Bradyrhizobium japonicum▿ †

    PubMed Central

    Mesa, Socorro; Hauser, Felix; Friberg, Markus; Malaguti, Emmanuelle; Fischer, Hans-Martin; Hennecke, Hauke

    2008-01-01

    Symbiotic N2 fixation in Bradyrhizobium japonicum is controlled by a complex transcription factor network. Part of it is a hierarchically arranged cascade in which the two-component regulatory system FixLJ, in response to a moderate decrease in oxygen concentration, activates the fixK2 gene. The FixK2 protein then activates not only a number of genes essential for microoxic respiration in symbiosis (fixNOQP and fixGHIS) but also further regulatory genes (rpoN1, nnrR, and fixK1). The results of transcriptome analyses described here have led to a comprehensive and expanded definition of the FixJ, FixK2, and FixK1 regulons, which, respectively, consist of 26, 204, and 29 genes specifically regulated in microoxically grown cells. Most of these genes are subject to positive control. Particular attention was addressed to the FixK2-dependent genes, which included a bioinformatics search for putative FixK2 binding sites on DNA (FixK2 boxes). Using an in vitro transcription assay with RNA polymerase holoenzyme and purified FixK2 as the activator, we validated as direct targets eight new genes. Interestingly, the adjacent but divergently oriented fixK1 and cycS genes shared the same FixK2 box for the activation of transcription in both directions. This recognition site may also be a direct target for the FixK1 protein, because activation of the cycS promoter required an intact fixK1 gene and either microoxic or anoxic, denitrifying conditions. We present evidence that cycS codes for a c-type cytochrome which is important, but not essential, for nitrate respiration. Two other, unexpected results emerged from this study: (i) specifically FixK1 seemed to exert a negative control on genes that are normally activated by the N2 fixation-specific transcription factor NifA, and (ii) a larger number of genes are expressed in a FixK2-dependent manner in endosymbiotic bacteroids than in culture-grown cells, pointing to a possible symbiosis-specific control. PMID:18689489

  3. NuTeV SSQT performance

    SciTech Connect

    Yu, J.; NuTeV

    1998-02-01

    The NuTeV experiment (E815) took data during the 1996-1997 Fermilab fixed target run. The experiment used the sign-selected-quadrupole- train (SSQT) in its neutrino beamline to choose either a neutrino or an anti- neutrino beam. This note summarizes the performance of the SSQT, as measured by the beamline monitoring devices, the observed {nu}{sub {mu}} and {anti {nu}}{sub {mu}} fluxes, and the upper limit on the wrong sign neutrino contamination.

  4. Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

    PubMed

    Tuononen, Katja; Mäki-Nevala, Satu; Sarhadi, Virinder Kaur; Wirtanen, Aino; Rönty, Mikko; Salmenkivi, Kaisa; Andrews, Jenny M; Telaranta-Keerie, Aino I; Hannula, Sari; Lagström, Sonja; Ellonen, Pekka; Knuuttila, Aija; Knuutila, Sakari

    2013-05-01

    The development of tyrosine kinase inhibitor treatments has made it important to test cancer patients for clinically significant gene mutations that influence the benefit of treatment. Targeted next-generation sequencing (NGS) provides a promising method for diagnostic purposes by enabling the simultaneous detection of multiple mutations in various genes in a single test. The aim of our study was to screen EGFR, KRAS, and BRAF mutations by targeted NGS and commonly used real-time polymerase chain reaction (PCR) methods to evaluate the feasibility of targeted NGS for the detection of the mutations. Furthermore, we aimed to identify potential novel mutations by targeted NGS. We analyzed formalin-fixed, paraffin-embedded (FFPE) tumor tissue specimens from 81 non-small cell lung carcinoma patients. We observed a significant concordance (from 96.3 to 100%) of the EGFR, KRAS, and BRAF mutation detection results between targeted NGS and real-time PCR. Moreover, targeted NGS revealed seven nonsynonymous single-nucleotide variations and one insertion-deletion variation in EGFR not detectable by the real-time PCR methods. The potential clinical significance of these variants requires elucidation in future studies. Our results support the use of targeted NGS in the screening of EGFR, KRAS, and BRAF mutations in FFPE tissue material.

  5. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... relationship of total final negotiated cost to total target cost. The final price is subject to a price ceiling, negotiated at the outset. The two forms of fixed-price incentive contracts, firm target and successive... becomes apparent that final negotiated cost will be substantially different from the target cost....

  6. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... establishing the final contract price by a formula based on the relationship of final negotiated total cost to total target cost. Fixed-price incentive contracts are covered in subpart 16.4, Incentive Contracts....

  7. Fixed solar energy concentrator

    SciTech Connect

    Houghton, A.J.; Knasel, T.M.

    1981-01-20

    An apparatus for the concentration of solar energy upon a fixed array of solar cells is disclosed. A transparent material is overlayed upon the cell array, and a diffuse reflective coating is applied to the surface area of the transparent medium in between cells. Radiant light, which reflects through the transparent layer and does not fall directly incident to a cell surface is reflected by the coating layer in an approximate cosine pattern. Thereafter, such light undergoes internal reflection and rediffusion until subsequently it either strikes a solar cell surface or is lost through the upper surface of the transparent material.

  8. Apparatus for fixing latency

    DOEpatents

    Hall, David R.; Bartholomew, David B.; Moon, Justin; Koehler, Roger O.

    2009-09-08

    An apparatus for fixing computational latency within a deterministic region on a network comprises a network interface modem, a high priority module and at least one deterministic peripheral device. The network interface modem is in communication with the network. The high priority module is in communication with the network interface modem. The at least one deterministic peripheral device is connected to the high priority module. The high priority module comprises a packet assembler/disassembler, and hardware for performing at least one operation. Also disclosed is an apparatus for executing at least one instruction on a downhole device within a deterministic region, the apparatus comprising a control device, a downhole network, and a downhole device. The control device is near the surface of a downhole tool string. The downhole network is integrated into the tool string. The downhole device is in communication with the downhole network.

  9. Fixed Access Network Sharing

    NASA Astrophysics Data System (ADS)

    Cornaglia, Bruno; Young, Gavin; Marchetta, Antonio

    2015-12-01

    Fixed broadband network deployments are moving inexorably to the use of Next Generation Access (NGA) technologies and architectures. These NGA deployments involve building fiber infrastructure increasingly closer to the customer in order to increase the proportion of fiber on the customer's access connection (Fibre-To-The-Home/Building/Door/Cabinet… i.e. FTTx). This increases the speed of services that can be sold and will be increasingly required to meet the demands of new generations of video services as we evolve from HDTV to "Ultra-HD TV" with 4k and 8k lines of video resolution. However, building fiber access networks is a costly endeavor. It requires significant capital in order to cover any significant geographic coverage. Hence many companies are forming partnerships and joint-ventures in order to share the NGA network construction costs. One form of such a partnership involves two companies agreeing to each build to cover a certain geographic area and then "cross-selling" NGA products to each other in order to access customers within their partner's footprint (NGA coverage area). This is tantamount to a bi-lateral wholesale partnership. The concept of Fixed Access Network Sharing (FANS) is to address the possibility of sharing infrastructure with a high degree of flexibility for all network operators involved. By providing greater configuration control over the NGA network infrastructure, the service provider has a greater ability to define the network and hence to define their product capabilities at the active layer. This gives the service provider partners greater product development autonomy plus the ability to differentiate from each other at the active network layer.

  10. Configurable hot spot fixing system

    NASA Astrophysics Data System (ADS)

    Kajiwara, Masanari; Kobayashi, Sachiko; Mashita, Hiromitsu; Aburada, Ryota; Furuta, Nozomu; Kotani, Toshiya

    2014-03-01

    Hot spot fixing (HSF) method has been used to fix many hot spots automatically. However, conventional HSF based on a biasing based modification is difficult to fix many hot spots under a low-k1 lithography condition. In this paper we proposed a new HSF, called configurable hotspot fixing system. The HSF has two major concepts. One is a new function to utilize vacant space around a hot spot by adding new patterns or extending line end edges around the hot spot. The other is to evaluate many candidates at a time generated by the new functions. We confirmed the proposed HSF improves 73% on the number of fixing hot spots and reduces total fixing time by 50% on a device layout equivalent to 28nm-node. The result shows the proposed HSF is effective for layouts under the low-k1 lithography condition.

  11. Simple Robust Fixed Lag Smoothing

    DTIC Science & Technology

    1988-12-02

    SIMPLE ROBUST FIXED LAG SMOOTHING by ~N. D. Le R.D. Martin 4 TECHNICAL RlEPORT No. 149 December 1988 Department of Statistics, GN-22 Accesion For...frLsD1ist Special A- Z Simple Robust Fixed Lag Smoothing With Application To Radar Glint Noise * N. D. Le R. D. Martin Department of Statistics, GN...smoothers. The emphasis here is on fixed-lag smoothing , as opposed to the use of existing robust fixed interval smoothers (e.g., as in Martin, 1979

  12. Why to treat subjects as fixed effects.

    PubMed

    Adelman, James S; Estes, Zachary

    2015-09-01

    Adelman, Marquis, Sabatos-DeVito, and Estes (2013) collected word naming latencies from 4 participants who read 2,820 words 50 times each. Their recommendation and practice was that R² targets set for models should take into account subject idiosyncrasies as replicable patterns, equivalent to a subjects-as-fixed-effects assumption. In light of an interaction involving subjects, they broke down the interaction into individual subject data. Courrieu and Rey's (2015) commentary argues that (a) single-subject data need not be more reliable than subject-average data, and (b) anyway, treating groups of subjects as random samples leads to valid conclusions about general mechanisms of reading. Point (a) was not part of Adelman et al.'s claim. In this reply, we examine the consequences of using the fixed-effect assumption. It (a) produces the correct target to check if by-items regression models contain all necessary variables, (b) more accurately constrains cognitive models, (c) more accurately reveals general mechanisms, and (d) can offer more powerful tests of effects. Even when individual differences are not the primary focus of a study, the fixed-effect analysis is often preferable to the random-effects analysis.

  13. Fixed points of quantum gravity.

    PubMed

    Litim, Daniel F

    2004-05-21

    Euclidean quantum gravity is studied with renormalization group methods. Analytical results for a nontrivial ultraviolet fixed point are found for arbitrary dimensions and gauge fixing parameters in the Einstein-Hilbert truncation. Implications for quantum gravity in four dimensions are discussed.

  14. Fixed drug eruption to sitagliptin.

    PubMed

    Gupta, Mrinal; Gupta, Anish

    2015-01-01

    Fixed drug eruption is a common adverse effect seen with various drugs notably antibiotics, antiepileptics and non-steroidal anti-inflammatory drugs. Herein we report a case of Sitagliptin induced fixed drug eruption in a 46 year old female who developed circumscribed, erythematous macules all over the body within one week of initiation of Sitagliptin. The lesions resolved with residual hyperpigmentation on cessation of the drug. The diagnosis was confirmed by an oral provocation test which led to a reactivation of the lesions. To the best of our knowledge, this is the first case of fixed drug eruption to Sitagliptin reported in the literature.

  15. Fixed drug eruption to propofol.

    PubMed

    Allchurch, L G V; Crilly, H

    2014-11-01

    We present a case of fixed drug eruption to propofol following a series of sedations of a patient for a number of day case procedures. The patient experienced oedema and blistering of his penis, increasing in severity and duration following each subsequent exposure. The diagnosis was confirmed by punch biopsy following an intravenous challenge test with propofol. Whilst reports of fixed drug eruptions to anaesthetic induction agents are uncommon, a number of drugs used commonly by anaesthetists are known triggers. We discuss fixed drug eruptions in relation to anaesthetic practice, aiming to raise awareness of this adverse drug reaction.

  16. Fixed exanthema from systemic tobramycin.

    PubMed

    García-Rubio, I; Martínez-Cócera, C; Robledo Echarren, T; Vázquez Cortés, S

    2006-01-01

    Eye drops contain several ophthalmic medications which can produce allergic reactions. We report the case of a patient with contact dermatitis from neomycin and a probable fixed exanthema after parenteral administration of tobramycin who tolerated topical tobramycin and other aminoglycosides.

  17. Evidence of the big fix

    NASA Astrophysics Data System (ADS)

    Hamada, Yuta; Kawai, Hikaru; Kawana, Kiyoharu

    2014-06-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value vh. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self-coupling are fixed when we vary vh. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental law in our case.

  18. Mobile versus fixed site lithotripsy.

    PubMed Central

    Lewis, C.; Burgess, N. A.; Feneley, R. C.; Matthews, P. N.

    1991-01-01

    The efficacy of a mobile Dornier HM4 lithotriptor, was compared with that of a fixed site Siemens Lithostar. A total of 115 calculi in 98 patients were treated, 55 on the mobile Dornier and 60 on the Lithostar. The groups were similar except for stone size, the mean of the Lithostar group being 11 mm compared with 7.7 mm in the Dornier group. Fragmentation rates were not significantly different, 88% and 75% on the mobile and fixed site machines, respectively and, at 3 months follow-up 66% and 46% were stone free or with fragments of less than 2 mm. There were no serious complications, and the incidence of mild complications was similar in the two groups. We conclude that the mobile Dornier HM4 is an effective lithotriptor and can offer several advantages over fixed site machines. PMID:1929134

  19. Fixed drug eruption to tartrazine.

    PubMed

    Orchard, D C; Varigos, G A

    1997-11-01

    An 11-year-old girl with a recurrent fixed drug eruption to tartrazine on the dorsum of the left hand is presented. Oral provocation tests to both the suspected food, an artificially coloured cheese crisp, and to tartrazine were positive. This case highlights fire need to consider artificial flavours, colours and preservatives as potential culprits in classic drug eruptions.

  20. Fixed Costs and Hours Constraints

    ERIC Educational Resources Information Center

    Johnson, William R.

    2011-01-01

    Hours constraints are typically identified by worker responses to questions asking whether they would prefer a job with more hours and more pay or fewer hours and less pay. Because jobs with different hours but the same rate of pay may be infeasible when there are fixed costs of employment or mandatory overtime premia, the constraint in those…

  1. Bar coded retroreflective target

    DOEpatents

    Vann, Charles S.

    2000-01-01

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  2. Optimal, Impulsive, Direct Ascent, Time-Fixed Orbital Interception.

    DTIC Science & Technology

    1985-01-01

    pp. 943-949. 10. Chiu, J. H. "Optimal Multiple-Impulse Nonlinear Orbital Rendezvous ." Ph.D. thesis, University of Illinois at Urbana-Champaign...the Earth. Each model is investigated for transfers in which the launch point is in the same plane as the target orbit (coplanar) and in which the...transfer times. Recent studies have explored orbital rendezvous for a specified 2 transfer time, i.e. time-fixed (10, 18, 29, 37). The time-fixed case is

  3. Variable delivery, fixed displacement pump

    SciTech Connect

    Sommars, Mark F.

    2001-01-01

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  4. Fixed-film biological processes

    SciTech Connect

    Josephson, J.

    1982-07-01

    During the 1970's, interest in fixed-film biological (FFB) processes for wastewater treatment has increased markedly. One reason for this is that these systems have a potential for considerable energy savings, as compared to conventional suspended-growth or activated-sludge systems, and certain FFB processes may eventually become energy producers. In this article, FFB processes are reviewed. Aerobic and anaerobic FFB systems are discussed and compared, along with a discussion of the toxic substances produced by FFB processes.

  5. Louisiana School-Based Health Centers: Annual Services Report, 1996-1997. Adolescent School Health Initiative Report.

    ERIC Educational Resources Information Center

    Louisiana State Office of Public Health, New Orleans. Dept. of Health and Hospitals.

    Since 1991, 23 school health centers have been established to serve children and families through locally sponsored health and education partnerships to improve the health and learning potential of Louisiana's public school students. This report presents information on the program operation in 1996-97. Section 1 of the report describes the growth…

  6. Synergistic Airframe-Propulsion Interactions and Integrations: A White Paper Prepared by the 1996-1997 Langley Aeronautics Technical Committee

    NASA Technical Reports Server (NTRS)

    Yaros, Steven F.; Sexstone, Matthew G.; Huebner, Lawrence D.; Lamar, John E.; McKinley, Robert E., Jr.; Torres, Abel O.; Burley, Casey L.; Scott, Robert C.; Small, William J.

    1998-01-01

    This white paper addresses the subject of Synergistic Airframe-Propulsion interactions and integrations (SnAPII). The benefits of SnAPII have not been as extensively explored. This is due primarily to the separateness of design process for airframes and propulsion systems, with only unfavorable interactions addressed. The question 'How to design these two systems in such a way that the airframe needs the propulsion and the propulsion needs the airframe?' is the fundamental issue addressed in this paper. Successful solutions to this issue depend on appropriate technology ideas. This paper first details some ten technologies that have yet to make it to commercial products (with limited exceptions) and that could be utilized in a synergistic manner. Then these technologies, either alone or in combination, are applied to both a conventional twin-engine transonic transport and to an unconventional transport, the Blended Wing Body. Lastly, combinations of these technologies are applied to configuration concepts to assess the possibilities of success relative to five of the ten NASA aeronautics goals. These assessments are subjective, but they point the way in which the applied technologies could work together for some break-through benefits.

  7. A Study to Determine the Biological Feasibility of a New Fish-Tagging System, 1996-1997; Annual Report.

    SciTech Connect

    Downing, Sandra L.; Jonasson, Bruce F.; Nunnallee, Edmund P.; Peterson, Bradley W.; Prentice, Earl F.

    1998-03-01

    This report covers work performed by National Marine Fisheries Service (NMFS) during 1996 and 1997 in cooperation with the Bonneville Power Administration (BPA). The project focused on expanding and improving PIT-tag technology throughout the Columbia River Basin (CRB).

  8. An investigation of homogeneous and heterogeneous sonochemistry for the destruction of hazardous substances. Progress report, 1996--1997

    SciTech Connect

    Hua, I.

    1997-01-01

    'The primary objective of this research project is to acquire a deeper fundamental knowledge of acoustic cavitation and cavitation chemistry, and in doing so, to ascertain how ultrasonic irradiation can be more effectively applied to environmental problems. Four on-going projects will be described in this progress report, The first project is the destruction of carbofuran in a Near-Field Acoustical Processor (NAP), and the hydrodynamic characterization of the reactor. The second project is a comprehensive study of how ultrasonic frequency influences sonochemical reaction rates; the substrate it, the preliminary portion of this study has been hydrogen peroxide formation. The third project in progress is destruction of four polychlorinated biphenyls at 20 kHz. Work so far has been at 20 kHz, but the most significant portion of this project will involve a multi-frequency (ultrasonic frequency) study. Finally, the destruction of a pesticide, dichlorvos, during sonication at 500 kHz will be described. Preliminary work during the first year has emphasized determination of kinetics; further work (years 2--3) will be focused upon closing mass balances and identifying transformation products.'

  9. Changes in Gas Bubble Disease Signs for Migrating Juvenile Salmonids Experimentally Exposed to Supersaturated Gasses, 1996-1997 Progress Report.

    SciTech Connect

    Absolon, Randall F.

    1999-03-01

    This study was designed to answer the question of whether gas bubble disease (GBD) signs change as a result of the hydrostatic conditions juvenile salmonids encounter when they enter the turbine intake of hydroelectric projects during their downstream migration.

  10. Epidemic O'Nyong-Nyong fever in southcentral Uganda, 1996-1997: entomologic studies in Bbaale village, Rakai District.

    PubMed

    Lutwama, J J; Kayondo, J; Savage, H M; Burkot, T R; Miller, B R

    1999-07-01

    Entomologic studies were conducted between January 27 and February 2, 1997, in Bbaale village in southcentral Uganda during an o'nyong-nyong (ONN) virus epidemic, which began in mid 1996 and continued into 1997. The objectives were to confirm the role of anophelines in ONN virus transmission and to examine other mosquito species as epidemic vectors of ONN virus. Of 10,050 mosquitoes collected using light traps and pyrethrum knockdown sprays, Anopheles (Cellia) funestus Giles was presumed to be the principal vector because it was the most abundant mosquito species from which a strain of ONN virus was isolated. This virus was isolated for the first time from a culicine species, Mansonia (Mansonioides) uniformis Theobald. Bwamba virus and Nyando virus were also isolated from An. funestus.

  11. Monitoring bank erosion at the Locke Island Archaeological National Register District: Summary of 1996/1997 field activities

    SciTech Connect

    Nickens, P.R.; Bjornstad, B.N.; Nickens, P.R.; Cadoret, N.A.; Wright, M.K.

    1998-08-01

    Locke Island is located in the Columbia River in south-central Washington. The US Department of Energy (DOE) owns Locke Island as part of its Hanford Site. In the 1960s and 1970s, as a result of intensive irrigation developments on the inland shoreline to the east of the island, the White Bluffs, which form the eastern boundary of the Columbia River channel in this area, began to show geological failures as excess irrigation water seeped out along the bluffs. One of the largest such failures, known as the Locke Island Landslide, is located just east of Locke Island. By the early 1980s, this landslide mass had moved westward into the river channel toward the island and was diverting the current at the island`s eastern perimeter. Erosion of the bank in the center of the island accelerated, threatening the cultural resources. By the early 1990s, the erosion had exposed cultural features and artifacts along the bank, leading to the beginning of intermittent monitoring of the cutbank. In 1994, DOE initiated more scheduled, systematic monitoring of island erosion to better understand the physical processes involved as well as mitigate ongoing loss of the archaeological record.

  12. Fixed-point quantum search.

    PubMed

    Grover, Lov K

    2005-10-07

    The quantum search algorithm consists of an iterative sequence of selective inversions and diffusion type operations, as a result of which it is able to find a state with desired properties (target state) in an unsorted database of size N in only sqrt[N] queries. This is achieved by designing the iterative transformations in a way that each iteration results in a small rotation of the state vector in a two-dimensional Hilbert space that includes the target state; if we choose the right number of iterative steps, we will stop just at the target state. This Letter shows that by replacing the selective inversions by selective phase shifts of pi/3, the algorithm preferentially converges to the target state irrespective of the step size or number of iterations. This feature leads to robust search algorithms and also to new schemes for quantum control and error correction.

  13. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved by the Coast Guard Marine Safety Center. However, ballast may be temporarily moved for vessel examination... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used,...

  14. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved by the Coast Guard Marine Safety Center or the ABS. However, ballast may be temporarily moved for vessel... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used,...

  15. FixJ: a major regulator of the oxygen limitation response and late symbiotic functions of Sinorhizobium meliloti.

    PubMed

    Bobik, Christine; Meilhoc, Eliane; Batut, Jacques

    2006-07-01

    Sinorhizobium meliloti exists either in a free-living state in the soil or in symbiosis within legume nodules, where the bacteria differentiate into nitrogen-fixing bacteroids. Expression of genes involved in nitrogen fixation and associated respiration is governed by two intermediate regulators, NifA and FixK, respectively, which are controlled by a two-component regulatory system FixLJ in response to low-oxygen conditions. In order to identify the FixLJ regulon, gene expression profiles were determined in microaerobic free-living cells as well as during the symbiotic life of the bacterium for the wild type and a fixJ null-mutant strain. We identified 122 genes activated by FixJ in either state, including 87 novel targets. FixJ controls 74% of the genes induced in microaerobiosis (2% oxygen) and the majority of genes expressed in mature bacteroids. Ninety-seven percent of FixJ-activated genes are located on the symbiotic plasmid pSymA. Transcriptome profiles of a nifA and a fixK mutant showed that NifA activates a limited number of genes, all specific to the symbiotic state, whereas FixK controls more than 90 genes, involved in free-living and/or symbiotic life. This study also revealed that FixJ has no other direct targets besides those already known. FixJ is involved in the regulation of functions such as denitrification or amino acid/polyamine metabolism and transport. Mutations in selected novel FixJ targets did not affect the ability of the bacteria to form nitrogen-fixing nodules on Medicago sativa roots. From these results, we propose an updated model of the FixJ regulon.

  16. Updraft Fixed Bed Gasification Aspen Plus Model

    SciTech Connect

    2007-09-27

    The updraft fixed bed gasification model provides predictive modeling capabilities for updraft fixed bed gasifiers, when devolatilization data is available. The fixed bed model is constructed using Aspen Plus, process modeling software, coupled with a FORTRAN user kinetic subroutine. Current updraft gasification models created in Aspen Plus have limited predictive capabilities and must be "tuned" to reflect a generalized gas composition as specified in literature or by the gasifier manufacturer. This limits the applicability of the process model.

  17. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway..., microwave communications, electrical power and similar towers, poles and structures, including stacks...

  18. Classification system adopted for fixed cutter bits

    SciTech Connect

    Winters, W.J.; Doiron, H.H.

    1988-01-01

    The drilling industry has begun adopting the 1987 International Association of Drilling Contractors' (IADC) method for classifying fixed cutter drill bits. By studying the classification codes on bit records and properly applying the new IADC fixed cutter dull grading system to recently run bits, the end-user should be able to improve the selection and usage of fixed cutter bits. Several users are developing databases for fixed cutter bits in an effort to relate field performance to some of the more prominent bit design characteristics.

  19. Simplifying fixed implant dental prosthetics.

    PubMed

    Tischler, Michael

    2011-01-01

    Through following the FPPD protocol for multiple adjacent implants, and delivering final abutments, picking up the metal framework, and delivering provisionals, many benefits are gained. The benefits of following the FPPD protocol are as follows: The restorative dentist is trying-in and delivering the final abutments in one visit as opposed to removing them and placing them multiple times. This requires less chair time and time for the patient. It also reduces the mechanical stress on the abutment screw and implant body due to the elimination of multiple try-in appointments. When the metal framework is tried-in and verified for fit, the restorative dentist has the opportunity check the retention, check the margins, and make any corrections that might be needed. The abutments will be staying in the mouth when the framework is picked up. This metal try-in allows for a verification of the bite to be given to the dental lab. The delivery of provisionals manufactured by the dental laboratory offers many advantages in the FPPD technique. The patient has a form of tooth much earlier in the traditional appointment sequence. The patient can now offer feedback to the doctor and laboratory for fabrication of the permanent prosthesis with regards to shape and color. The laboratory-fabricated provisionals offer progressive loading to the implants through having a reduced occlusion yet allowing food to stimulate the implants. Overall, the FPPD technique offers shorter appointment times, more rapid delivery of fixed supported teeth, improved doctor-technician communication, and less mechanical wear on the implant parts.

  20. Fixed-Response Questions with a Difference.

    ERIC Educational Resources Information Center

    Johnstone, Alex H.; Ambusaidi, Abdullah

    2002-01-01

    Offers three types of fixed-response questions that are designed to overcome drawbacks appearing in the conventional forms of fixed-response questions such as not allowing the examiner to investigate reasoning, background, or prevent guessing. (Contains 14 references.) (Author/YDS)

  1. Negotiating a Fixed-Unit Price Contract.

    ERIC Educational Resources Information Center

    Pasquale, Mathew; Morrison, Wade

    1986-01-01

    Discusses the concept of "fixed-unit price contracting," an arrangement that is becoming popular with private industry councils (PICs). Guidelines include (1) find out as much as you can about the PIC's requirements; (2) figure out whether you can meet the PIC's requirements; and (3) keep in mind that most elements of a fixed-unit price…

  2. Statistical analysis of fixed income market

    NASA Astrophysics Data System (ADS)

    Bernaschi, Massimo; Grilli, Luca; Vergni, Davide

    2002-05-01

    We present cross and time series analysis of price fluctuations in the US Treasury fixed income market. Bonds have been classified according to a suitable metric based on the correlation among them. The classification shows how the correlation among fixed income securities depends strongly on their maturity. We study also the structure of price fluctuations for single time series.

  3. Properties of Fixed-Fixed Models and Alternatives in Presence-Absence Data Analysis

    PubMed Central

    Kallio, Aleksi

    2016-01-01

    Assessing the significance of patterns in presence-absence data is an important question in ecological data analysis, e.g., when studying nestedness. Significance testing can be performed with the commonly used fixed-fixed models, which preserve the row and column sums while permuting the data. The manuscript considers the properties of fixed-fixed models and points out how their strict constraints can lead to limited randomizability. The manuscript considers the question of relaxing row and column sun constraints of the fixed-fixed models. The Rasch models are presented as an alternative with relaxed constraints and sound statistical properties. Models are compared on presence-absence data and surprisingly the fixed-fixed models are observed to produce unreasonably optimistic measures of statistical significance, giving interesting insight into practical effects of limited randomizability. PMID:27812126

  4. Properties of Fixed-Fixed Models and Alternatives in Presence-Absence Data Analysis.

    PubMed

    Kallio, Aleksi

    2016-01-01

    Assessing the significance of patterns in presence-absence data is an important question in ecological data analysis, e.g., when studying nestedness. Significance testing can be performed with the commonly used fixed-fixed models, which preserve the row and column sums while permuting the data. The manuscript considers the properties of fixed-fixed models and points out how their strict constraints can lead to limited randomizability. The manuscript considers the question of relaxing row and column sun constraints of the fixed-fixed models. The Rasch models are presented as an alternative with relaxed constraints and sound statistical properties. Models are compared on presence-absence data and surprisingly the fixed-fixed models are observed to produce unreasonably optimistic measures of statistical significance, giving interesting insight into practical effects of limited randomizability.

  5. Optimal mixing and optimal stirring for fixed energy, fixed power, or fixed palenstrophy flows

    NASA Astrophysics Data System (ADS)

    Lunasin, Evelyn; Lin, Zhi; Novikov, Alexei; Mazzucato, Anna; Doering, Charles R.

    2012-11-01

    We consider passive scalar mixing by a prescribed divergence-free velocity vector field in a periodic box and address the following question: Starting from a given initial inhomogeneous distribution of passive tracers, and given a certain energy budget, power budget, or finite palenstrophy budget, what incompressible flow field best mixes the scalar quantity? We focus on the optimal stirring strategy recently proposed by Lin et al. ["Optimal stirring strategies for passive scalar mixing," J. Fluid Mech. 675, 465 (2011)], 10.1017/S0022112011000292 that determines the flow field that instantaneously maximizes the depletion of the H-1 mix-norm. In this work, we bridge some of the gap between the best available a priori analysis and simulation results. After recalling some previous analysis, we present an explicit example demonstrating finite-time perfect mixing with a finite energy constraint on the stirring flow. On the other hand, using a recent result by Wirosoetisno et al. ["Long time stability of a classical efficient scheme for two dimensional Navier-Stokes equations," SIAM J. Numer. Anal. 50(1), 126-150 (2012)], 10.1137/110834901 we establish that the H-1 mix-norm decays at most exponentially in time if the two-dimensional incompressible flow is constrained to have constant palenstrophy. Finite-time perfect mixing is thus ruled out when too much cost is incurred by small scale structures in the stirring. Direct numerical simulations in two dimensions suggest the impossibility of finite-time perfect mixing for flows with fixed power constraint and we conjecture an exponential lower bound on the H-1 mix-norm in this case. We also discuss some related problems from other areas of analysis that are similarly suggestive of an exponential lower bound for the H-1 mix-norm.

  6. Fixed Interval Smoothing Algorithm for an Extended Kalman Filter for Over-the-Horizon Ship Tracking

    DTIC Science & Technology

    1989-03-01

    accurate than an estimate based only on the estimates up to time k, (.k,). Meditch [Ref. 10: p. 193] categorizes smoothing algorithms into three...NAVAL POSTGRADUATE SCHOOL Monterey, California DTIC ELECTE A JUN0 89 * TEESIS In * FIXED INTERVAL SMOOTHING ALGORITHM FOR A\\ EXTENDED KALMAN 0 FILTER...track a maneuvering surface target using HFDF lines-of-bearing is sub -tantially improved by implementing a fixed interval smoothing algorithm and a

  7. NASA Fixed Wing Project: Green Technologies for Future Aircraft Generation

    NASA Technical Reports Server (NTRS)

    Del Rosario, Ruben; Koudelka, John M.; Wahls, Rich; Madavan, Nateri

    2014-01-01

    Commercial aviation relies almost entirely on subsonic fixed wing aircraft to constantly move people and goods from one place to another across the globe. While air travel is an effective means of transportation providing an unmatched combination of speed and range, future subsonic aircraft must improve substantially to meet efficiency and environmental targets.The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. Multidisciplinary advances are required in aerodynamic efficiency to reduce drag, structural efficiency to reduce aircraft empty weight, and propulsive and thermal efficiency to reduce thrust-specific energy consumption (TSEC) for overall system benefit. Additionally, advances are required to reduce perceived noise without adversely affecting drag, weight, or TSEC, and to reduce harmful emissions without adversely affecting energy efficiency or noise.The paper will highlight the Fixed Wing project vision of revolutionary systems and technologies needed to achieve these challenging goals. Specifically, the primary focus of the FW Project is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe

  8. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway... consisting of individual rungs that are attached to walls, conical manhole sections or river cells shall:...

  9. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway... consisting of individual rungs that are attached to walls, conical manhole sections or river cells shall:...

  10. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway... consisting of individual rungs that are attached to walls, conical manhole sections or river cells shall:...

  11. 78 FR 20705 - Fixed Income Roundtable

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Fixed Income Roundtable AGENCY: Securities and Exchange Commission. ACTION: Notice of roundtable discussion; request for comment. SUMMARY: The Securities and Exchange Commission will host a one...

  12. Anderson Acceleration for Fixed-Point Iterations

    SciTech Connect

    Walker, Homer F.

    2015-08-31

    The purpose of this grant was to support research on acceleration methods for fixed-point iterations, with applications to computational frameworks and simulation problems that are of interest to DOE.

  13. Fluconazole-induced Fixed Drug Eruption.

    PubMed

    Gaiser, Cory Allen; Sabatino, Dominick

    2013-03-01

    Triazole antifungals are commonly used in the treatment of oral, esophageal, and vaginal candidiasis. Fluconazole is frequently prescribed as the therapy modality for vaginal fungal infections. On rare occasions, fluconazole has been shown to cause fixed drug eruptions. Lesions of fixed drug eruptions vary in size and number, but have the same general appearance and symptoms. The authors report a case of fluconazole-induced fixed drug eruption in a 24-year-old woman with recurrent vaginal candidiasis. The lesion was initially diagnosed as a spider bite. Topical and oral provocation tests with fluconazole were performed. Topical provocation with petroleum/fluconazole and dimethyl sulfoxide/fluonazole were both negative. Oral provocation was positive, thus confirming the diagnosis of fluconazole-induced fixed drug eruption.

  14. Fracture Control for Fixed Offshore Structures.

    DTIC Science & Technology

    1984-12-01

    CRA&I DTIC TAB Unannounced E Jfstification Avil a’idjor iv Listing of Acronyms and Symbols ABS American Bureau of Shipping API American Petroleum Institute API...the American Petroleum Institute which is the primary design guide for American fixed offshore structures (see reference listings) ASCE American...Planning, Designing, and Constructing Fixed Offshore Platforms," API RP-2A, Thirteenth Edition, published by the American Petroleum Institute , Washington

  15. Precise Point Positioning with Partial Ambiguity Fixing.

    PubMed

    Li, Pan; Zhang, Xiaohong

    2015-06-10

    Reliable and rapid ambiguity resolution (AR) is the key to fast precise point positioning (PPP). We propose a modified partial ambiguity resolution (PAR) method, in which an elevation and standard deviation criterion are first used to remove the low-precision ambiguity estimates for AR. Subsequently the success rate and ratio-test are simultaneously used in an iterative process to increase the possibility of finding a subset of decorrelated ambiguities which can be fixed with high confidence. One can apply the proposed PAR method to try to achieve an ambiguity-fixed solution when full ambiguity resolution (FAR) fails. We validate this method using data from 450 stations during DOY 021 to 027, 2012. Results demonstrate the proposed PAR method can significantly shorten the time to first fix (TTFF) and increase the fixing rate. Compared with FAR, the average TTFF for PAR is reduced by 14.9% for static PPP and 15.1% for kinematic PPP. Besides, using the PAR method, the average fixing rate can be increased from 83.5% to 98.2% for static PPP, from 80.1% to 95.2% for kinematic PPP respectively. Kinematic PPP accuracy with PAR can also be significantly improved, compared to that with FAR, due to a higher fixing rate.

  16. Precise Point Positioning with Partial Ambiguity Fixing

    PubMed Central

    Li, Pan; Zhang, Xiaohong

    2015-01-01

    Reliable and rapid ambiguity resolution (AR) is the key to fast precise point positioning (PPP). We propose a modified partial ambiguity resolution (PAR) method, in which an elevation and standard deviation criterion are first used to remove the low-precision ambiguity estimates for AR. Subsequently the success rate and ratio-test are simultaneously used in an iterative process to increase the possibility of finding a subset of decorrelated ambiguities which can be fixed with high confidence. One can apply the proposed PAR method to try to achieve an ambiguity-fixed solution when full ambiguity resolution (FAR) fails. We validate this method using data from 450 stations during DOY 021 to 027, 2012. Results demonstrate the proposed PAR method can significantly shorten the time to first fix (TTFF) and increase the fixing rate. Compared with FAR, the average TTFF for PAR is reduced by 14.9% for static PPP and 15.1% for kinematic PPP. Besides, using the PAR method, the average fixing rate can be increased from 83.5% to 98.2% for static PPP, from 80.1% to 95.2% for kinematic PPP respectively. Kinematic PPP accuracy with PAR can also be significantly improved, compared to that with FAR, due to a higher fixing rate. PMID:26067196

  17. Continuous, fixed-ratio, and fixed-interval reinforcement in honey bees

    PubMed Central

    Grossmann, Klaus E.

    1973-01-01

    Bees learned to enter a Plexiglas tube and to suck small portions of sugar solution; every entry or every fifth entry was reinforced. During an extinction phase, the bees on the fixed-ratio schedule emitted twice as many responses as did those given continuous reinforcement. Bees on a fixed-interval schedule of reinforcement emitted lower response rates than did those given fixed-ratio reinforcement. By extending the conditioning procedure for several days, it was possible to maintain responding with fixed-ratio schedules requiring 30 responses per reinforcement and with fixed-interval values up to 90 sec. Under fixed-interval schedules, response rates did not increase toward the end of the reinforcement intervals. PMID:16811686

  18. It is not a fixed drug eruption, it is a fixed "sunlight" eruption.

    PubMed

    Valdivieso, Rommel; Cañarte, Cecilia

    2010-12-01

    Hyperpigmented fixed eruption is a phenomenon usually related with drug antigens, and known as fixed drug eruption. A woman had a skin condition with clinical and histopathologic indications of fixed drug eruption. The disease first appeared when she went to a swimming pool and left with hyperpigmented macules. Previously affected skin reactivated on three other occasions when she again visited swimming pools. Sunlight involvement (UVA-UVB) was demonstrated through phototests. Sunlight should be considered as a cause of fixed drug-like eruption and a possible cause of some cases of FDE without any apparent etiological factor.

  19. Au Fixed Point Development at NRC

    NASA Astrophysics Data System (ADS)

    Dedyulin, S. N.; Gotoh, M.; Todd, A. D. W.

    2017-04-01

    Two Au fixed points filled using metal of different nominal purities in carbon crucibles have been developed at the National Research Council Canada (NRC). The primary motivation behind this project was to provide the means for direct thermocouple calibrations at the Au freezing point (1064.18°C). Using a Au fixed point filled with the metal of maximum available purity [99.9997 % pure according to glow discharge mass spectroscopy (GDMS)], multiple freezing plateaus were measured in a commercial high-temperature furnace. Four Pt/Pd thermocouples constructed and calibrated in-house were used to measure the freezing plateaus. From the calibration at Sn, Zn, Al and Ag fixed points, the linear deviation function from the NIST-IMGC reference function (IEC 62460:2008 Standard) was determined and extrapolated to the freezing temperature of Au. For all the Pt/Pd thermocouples used in this study, the measured EMF values agree with the extrapolated values within expanded uncertainty, thus substantiating the use of 99.9997 % pure Au fixed point cell for thermocouple calibrations at NRC. Using the Au fixed point filled with metal of lower purity (99.99 % pure according to GDMS), the effect of impurities on the Au freezing temperature measured with Pt/Pd thermocouple was further investigated.

  20. Inadvertent tooth movement with fixed lingual retainers.

    PubMed

    Shaughnessy, Timothy G; Proffit, William R; Samara, Said A

    2016-02-01

    Fixed retainers are effective in maintaining the alignment of the anterior teeth more than 90% of the time, but they can produce inadvertent tooth movement that in the most severe instances requires orthodontic retreatment managed with a periodontist. This is different from relapse into crowding when a fixed retainer is lost. These problems arise when the retainer breaks but remains bonded to some or all teeth, or when an intact retainer is distorted by function or was not passive when bonded. In both instances, torque of the affected teeth is the predominant outcome. A fixed retainer made with dead soft wire is the least likely to create torque problems but is the most likely to break. Highly flexible twist wires bonded to all the teeth appear to be the most likely to produce inadvertent tooth movement, but this also can occur with stiffer wires bonded only to the canines. Orthodontists, general dentists, and patients should be aware of possible problems with fixed retainers, especially those with all teeth bonded, because the patient might not notice partial debonding. Regular observations of patients wearing fixed retainers by orthodontists in the short term and family dentists in the long term are needed.

  1. Autonomous search and surveillance with small fixed wing aircraft

    NASA Astrophysics Data System (ADS)

    McGee, Timothy Garland

    Small unmanned aerial vehicles (UAVs) have the potential to act as low cost tools in a variety of both civilian and military applications including traffic monitoring, border patrol, and search and rescue. While most current operational UAV systems require human operators, advances in autonomy will allow these systems to reach their full potential as sensor platforms. This dissertation specifically focuses on developing advanced control, path planning, search, and image processing techniques that allow small fixed wing aircraft to autonomously collect data. The problems explored were motivated by experience with the development and experimental flight testing of a fleet of small autonomous fixed wing aircraft. These issues, which have not been fully addressed in past work done on ground vehicles or autonomous helicopters, include the influence of wind and turning rate constraints, the non-negligible velocity of ground targets relative to the aircraft velocity, and limitations on sensor size and processing power on small vehicles. Several contributions for the autonomous operation of small fixed wing aircraft are presented. Several sliding surface controllers are designed which extend previous techniques to include variable sliding surface coefficients and the use of spatial vehicle dynamics. These advances eliminate potential singularities in the control laws to follow spatially defined paths and allow smooth transition between controllers. The optimal solution for the problem of path planning through an ordered set of points for an aircraft with a bounded turning rate in the presence of a constant wind is then discussed. Path planning strategies are also explored to guarantee that a searcher will travel within sensing distance of a mobile ground target. This work assumes only a maximum velocity of the target and is designed to succeed for any possible path of the target. Closed-loop approximations of both the path planning and search techniques, using the sliding

  2. Final report : results of the 2007 targeted investigation at Hilton, Kansas.

    SciTech Connect

    LaFreniere, L. M.; Environmental Science Division

    2008-04-29

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility in Hilton, Kansas, in 1954-1965. In 1992, carbon tetrachloride was first identified, at a concentration of 910 {micro}g/L, in groundwater from well GW01 at Hilton. This discovery occurred in association with the sale of the private grain storage facility on which well GW01 is located to the current owner, the Mid-Kansas Cooperative Association. The Kansas Department of Health and Environment conducted investigations at Hilton in 1992-1994. In 1996-1997, Argonne National Laboratory conducted Phase I and Phase II investigations on behalf of the CCC/USDA to characterize the distribution of the carbon tetrachloride contamination identified in well GW01, the stratigraphic units potentially hosting contaminant migration, and local hydrogeology in the Hilton area. The 2007 targeted investigation reported here focused specifically on the former CCC/USDA property at Hilton, west of the railroad tracks. (Until a property record search in 2005, the location of the CCC/USDA's former facility at Hilton was not known with certainty.) The objectives of the investigation, as implemented, were to (1) investigate for carbon tetrachloride contamination in the shallower soil and shallow aquifer units below the former CCC/USDA property and (2) investigate groundwater flow patterns. The key results of the 2007 targeted investigation are as follows: (1) No carbon tetrachloride or chloroform contamination was found in soil or groundwater below the former CCC/USDA facility. (2) The 2007 groundwater level data support a southwesterly direction for groundwater flow in the main Hilton aquifer (Equus Beds), consistent with findings of previous investigations. Contaminated well GW01 was confirmed to be upgradient from the former CCC/USDA facility. (3) The contaminants carbon tetrachloride, chloroform, and 1,2-dibromoethane (ethylene dibromide) were found in

  3. Fixed-ratio escape reinforcement1

    PubMed Central

    Azrin, N. H.; Holz, W. C.; Hake, D. F.; Ayllon, T.

    1963-01-01

    Escape responses of squirrel monkeys were reinforced according to a fixed-ratio schedule. The reinforcement was a period of safety from a stimulus that signalled the delivery of intermittent pain-shocks. When the frequency of shock was gradually reduced, the performance remained at a high level until the shocks were quite infrequent. Similarly, the duration of the period of safety could be reduced to a few seconds with little loss of behavior. Thus, the responses appeared to be reinforced by even a brief period of safety, the actual degree of shock reduction being fairly slight. The changes in responding during this fixed-ratio escape procedure were comparable to the response changes typically obtained during fixed-ratio food procedures. PMID:13965780

  4. Carbon-Fixing Reactions of Photosynthesis.

    PubMed

    2016-07-01

    Summaryplantcell;28/7/tpc.116.tt0716/FIG1F1fig1Photosynthesis in plants converts the energy of sunlight into chemical energy. Although photosynthesis involves many proteins and catalytic processes, it often is described as two sets of reactions, the light-dependent reactions and the carbon-fixing reactions. This lesson introduces the core biochemistry of the carbon-fixing reactions of photosynthesis, as well as its variations, C4 and CAM. Finally, it addresses how and why plants are affected by rising atmospheric CO2 levels, and research efforts to increase photosynthetic efficiency in current and future conditions.

  5. Tranexamic Acid-Induced Fixed Drug Eruption

    PubMed Central

    Matsumura, Natsuko; Hanami, Yuka; Yamamoto, Toshiyuki

    2015-01-01

    A 33-year-old male showed multiple pigmented patches on his trunk and extremities after he took tranexamic acid for common cold. He stated that similar eruptions appeared when he was treated with tranexamic acid for influenza 10 months before. Patch test showed positive results at 48 h and 72 h by 1% and 10% tranexamic acid at the lesional skin only. To our knowledge, nine cases of fixed drug eruption induced by tranexamic acid have been reported in Japan. Tranexamic acid is a safe drug and frequently used because of its anti-fibrinolytic and anti-inflammatory effects, but caution of inducing fixed drug eruption should be necessary. PMID:26288438

  6. Fixed Wordsize Implementation of Lifting Schemes

    NASA Astrophysics Data System (ADS)

    Karp, Tanja

    2006-12-01

    We present a reversible nonlinear discrete wavelet transform with predefined fixed wordsize based on lifting schemes. Restricting the dynamic range of the wavelet domain coefficients due to a fixed wordsize may result in overflow. We show how this overflow has to be handled in order to maintain reversibility of the transform. We also perform an analysis on how large a wordsize of the wavelet coefficients is needed to perform optimal lossless and lossy compressions of images. The scheme is advantageous to well-known integer-to-integer transforms since the wordsize of adders and multipliers can be predefined and does not increase steadily. This also results in significant gains in hardware implementations.

  7. Tranexamic Acid-Induced Fixed Drug Eruption.

    PubMed

    Matsumura, Natsuko; Hanami, Yuka; Yamamoto, Toshiyuki

    2015-01-01

    A 33-year-old male showed multiple pigmented patches on his trunk and extremities after he took tranexamic acid for common cold. He stated that similar eruptions appeared when he was treated with tranexamic acid for influenza 10 months before. Patch test showed positive results at 48 h and 72 h by 1% and 10% tranexamic acid at the lesional skin only. To our knowledge, nine cases of fixed drug eruption induced by tranexamic acid have been reported in Japan. Tranexamic acid is a safe drug and frequently used because of its anti-fibrinolytic and anti-inflammatory effects, but caution of inducing fixed drug eruption should be necessary.

  8. 48 CFR 16.306 - Cost-plus-fixed-fee contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... report of research accomplishing the goal or target) within the estimated cost, if possible, as a... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-plus-fixed-fee... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.306...

  9. Sputter target

    DOEpatents

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  10. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.27 Fixed ladders. (a) Design... details shall be such as to prevent or minimize the accumulation of water on wood parts. (iii) When.... Ladder safety devices may be used on tower, water tank, and chimney ladders over 20 feet in...

  11. Stress tolerant crops from nitrogen fixing trees

    SciTech Connect

    Becker, R.; Saunders, R.M.

    1983-01-01

    Notes are given on the nutritional quality and uses of: pods of Geoffroea decorticans, a species tolerant of saline and limed soils and saline water; seeds of Olneya tesota which nodulates readily and fixes nitrogen and photosynthesizes at low water potential; and pods of Prosopis chilensis and P. tamarugo which tolerate long periods without rain. 3 references.

  12. Route Optimization for Offloading Congested Meter Fixes

    NASA Technical Reports Server (NTRS)

    Xue, Min; Zelinski, Shannon

    2016-01-01

    The Optimized Route Capability (ORC) concept proposed by the FAA facilitates traffic managers to identify and resolve arrival flight delays caused by bottlenecks formed at arrival meter fixes when there exists imbalance between arrival fixes and runways. ORC makes use of the prediction capability of existing automation tools, monitors the traffic delays based on these predictions, and searches the best reroutes upstream of the meter fixes based on the predictions and estimated arrival schedules when delays are over a predefined threshold. Initial implementation and evaluation of the ORC concept considered only reroutes available at the time arrival congestion was first predicted. This work extends previous work by introducing an additional dimension in reroute options such that ORC can find the best time to reroute and overcome the 'firstcome- first-reroute' phenomenon. To deal with the enlarged reroute solution space, a genetic algorithm was developed to solve this problem. Experiments were conducted using the same traffic scenario used in previous work, when an arrival rush was created for one of the four arrival meter fixes at George Bush Intercontinental Houston Airport. Results showed the new approach further improved delay savings. The suggested route changes from the new approach were on average 30 minutes later than those using other approaches, and fewer numbers of reroutes were required. Fewer numbers of reroutes reduce operational complexity and later reroutes help decision makers deal with uncertain situations.

  13. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Steel Rails and Round Steel Rungs (c) Clearance—(1) Climbing side. On fixed ladders, the perpendicular... back of ladder. The distance from the centerline of rungs, cleats, or steps to the nearest permanent object in back of the ladder shall be not less than 7 inches, except that when unavoidable...

  14. Long-term fixed income market structure

    NASA Astrophysics Data System (ADS)

    Grilli, Luca

    2004-02-01

    Long-term fixed income market securities present a strong positive correlation in daily returns. By using a metrical approach and considering “modified” time series, I show how it is possible to show a more complex structure which depends strictly on the maturity date.

  15. 29 CFR 1917.120 - Fixed stairways.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...). (4) Railing height from tread surface at the riser face shall be 33±3 inches (83.82 cm ±7.62 cm). (5... the tread surface at the riser face. (6) Maintenance. Fixed stairways shall be maintained in...

  16. The microanalysis of fixed-interval responding

    PubMed Central

    Gentry, G. David; Weiss, Bernard; Laties, Victor G.

    1983-01-01

    The fixed-interval schedule of reinforcement is one of the more widely studied schedules in the experimental analysis of behavior and is also a common baseline for behavior pharmacology. Despite many intensive studies, the controlling variables and the pattern of behavior engendered are not well understood. The present study examined the microstructure and superstructure of the behavior engendered by a fixed-interval 5- and a fixed-interval 15-minute schedule of food reinforcement in the pigeon. Analysis of performance typical of fixed-interval responding indicated that the scalloped pattern does not result from smooth acceleration in responding, but, rather, from renewed pausing early in the interval. Individual interresponse-time (IRT) analyses provided no evidence of acceleration. There was a strong indication of alternation in shorter-longer IRTs, but these shorter-longer IRTs did not occur at random, reflecting instead a sequential dependency in successive IRTs. Furthermore, early in the interval there was a high relative frequency of short IRTs. Such a pattern of early pauses and short IRTs does not suggest behavior typical of reinforced responding as exemplified by the pattern found near the end of the interval. Thus, behavior from clearly scalloped performance can be classified into three states: postreinforcement pause, interim behavior, and terminal behavior. PMID:16812324

  17. Fixed drug eruption due to ornidazole.

    PubMed

    Gupta, Ramji

    2014-11-01

    A 56-year-old male developed an ulcer on his glans penis and mucosae of upper and lower lips 3 days after taking ofloxacin, cephalexin, and ornidazole. Clinically, a provisional diagnosis of fixed drug eruption was made. The causative drug was confirmed by an oral provocation test which triggered a reactivation of all lesions only with ornidazole.

  18. Fixed drug eruption related to fluconazole.

    PubMed

    Lai, Olivia; Hsu, Sylvia

    2016-04-18

    Fixed drug eruption (FDE) is a type of cutaneous drug reaction that occurs at the same sites upon re-exposure to specific medications. Herein we discuss the case of a 23-year-old man with a FDE to fluconazole.

  19. Microanalysis of fixed-interval responding

    SciTech Connect

    Gentry, G.D.; Weiss, B.; Laties, V.G.

    1983-03-01

    The fixed-interval schedule of reinforcement is one of the more widely studied schedules in the experimental analysis of behavior and is also a common baseline for behavior pharmacology. Despite many intensive studies, the controlling variables and the pattern of behavior engendered are not well understood. The present study examined the microstructure and superstructure of the behavior engendered by a fixed-interval 5- and a fixed-interval 15-minute schedule of food reinforcement in the pigeon. Analysis of performance typical of fixed-interval responding indicated that the scalloped pattern does not result from smooth acceleration in responding, but, rather, from renewed pausing early in the interval. Individual interresponse-time (IRT) analyses provided no evidence of acceleration. There was a strong indication of alternation is shorter-longer IRTs, but these shorter-longer IRTs did not occur at random, reflecting instead a sequential dependency in successive IRTs. Furthermore, early in the interval there was a high relative frequency of short IRTs. Such a pattern of early pauses and short IRTs does not suggest behavior typical of reinforced responding as exemplified by the pattern found near the end of the interval. Thus, behavior from clearly scalloped performance can be classified into three states: postreinforcement pause, interim behavior, and terminal behavior. 31 references, 11 figures, 4 tables.

  20. Fixing the Shadows While Moving the Gnomon

    ERIC Educational Resources Information Center

    Gangui, Alejandro

    2015-01-01

    It is a common practice to fix a vertical gnomon and study the moving shadow cast by it. This shows our local solar time and gives us a hint regarding the season in which we perform the observation. The moving shadow can also tell us our latitude with high precision. In this paper we propose to exchange the roles and while keeping the shadows…

  1. Force dynamics in fixed-ratio schedules.

    PubMed

    Pinkston, Jonathan W; McBee, Lindsey N

    2014-03-01

    Fixed-ratio schedules are widely used in behavioral research. Although fixed-ratio schedules often conjure up relationships to work and effort, little is known about effort-related measures in these schedules. Early research had shown that force and effort of operant behavior vary systematically during the execution of ratio schedules, and the goal of the present study was to revisit early research on force dynamics in fixed-ratio schedules. Four rats earned sucrose by pressing an isometric force transducer. Presses produced sucrose after ten or twenty responses. In general, the force of responses increased then decreased systematically across the ratio. The possibility that decreases in force during ratio execution was due to a trade-off with the differential reinforcement of short inter-response times (IRT) was investigated in an additional condition where sucrose was made available according to a tandem fixed-ratio 19 inter-response (IRT)> t schedule. The tandem IRT requirement did not eliminate decreasing trends in force across the ratio; unexpectedly, the tandem requirement did eliminate increases in force early in the ratio, which may reflect sequence-level organization operating in the control of force dynamics.

  2. Deep Learning Experiences within a Fixed Schedule

    ERIC Educational Resources Information Center

    Green, Julie; Olmstead, Laurie

    2011-01-01

    Two and a half years ago, elementary school librarians in the Birmingham Public School district (Troy, Michigan) had to change to a fixed schedule for half the day with kindergarten through second grade students. This change was due to cutbacks and the need for common planning time among classroom teachers. School librarians found themselves…

  3. 46 CFR 28.260 - Electronic position fixing devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Electronic position fixing devices. 28.260 Section 28... Trade § 28.260 Electronic position fixing devices. Each vessel 79 feet (24 meters) or more in length must be equipped with an electronic position fixing device capable of providing accurate fixes for...

  4. 46 CFR 28.260 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Electronic position fixing devices. 28.260 Section 28... Trade § 28.260 Electronic position fixing devices. Each vessel 79 feet (24 meters) or more in length must be equipped with an electronic position fixing device capable of providing accurate fixes for...

  5. 50 CFR 660.211 - Fixed gear fishery-definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Fixed gear fishery-definitions. 660.211... Groundfish-Limited Entry Fixed Gear Fisheries § 660.211 Fixed gear fishery—definitions. These definitions are specific to the limited entry fixed gear fisheries covered in this subpart. General groundfish...

  6. 50 CFR 660.211 - Fixed gear fishery-definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Fixed gear fishery-definitions. 660.211... Groundfish-Limited Entry Fixed Gear Fisheries § 660.211 Fixed gear fishery—definitions. These definitions are specific to the limited entry fixed gear fisheries covered in this subpart. General groundfish...

  7. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Fixed gear identification and marking... West Coast Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked...

  8. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Fixed gear identification and marking... West Coast Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked...

  9. 50 CFR 660.211 - Fixed gear fishery-definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Fixed gear fishery-definitions. 660.211... Groundfish-Limited Entry Fixed Gear Fisheries § 660.211 Fixed gear fishery—definitions. These definitions are specific to the limited entry fixed gear fisheries covered in this subpart. General groundfish...

  10. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Fixed gear identification and marking. 660... Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked at the surface and at...

  11. 50 CFR 660.211 - Fixed gear fishery-definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Fixed gear fishery-definitions. 660.211... Groundfish-Limited Entry Fixed Gear Fisheries § 660.211 Fixed gear fishery—definitions. These definitions are specific to the limited entry fixed gear fisheries covered in this subpart. General groundfish...

  12. Data from Fermilab E-687 (Photoproduction of Heavy Flavours) and Fermilab E-831 (FOCUS)

    DOE Data Explorer

    The FERMILAB E687 Collaboration studies production and decay properties of heavy flavours produced in photon-hadron interactions. The experiment recorded approximately 500 million hadronic triggers in the 1990-91 fixed target run at Fermilab from which over 80 thousand charm decays were fully reconstructed. Physics publications include the precision lifetime measurements of the charm hadrons, D meson semileptonic form factors, detailed Dalitz plot analyses, charm meson and baryon decay modes and spectroscopy, searches for rare and forbidden phenomena, and tests of QCD production mechanisms. The follow-on experiment FOCUS Collaboration (Fermilab E831) successfully recorded huge amount of data during the 1996-1997 fixed target run. The FOCUS home page is located at http://www-focus.fnal.gov/. FOCUS is an international collaboration with institutions in Brazil, Italy, South Korea, Mexico, Puerto Rico, and the U.S.

  13. Implementation Considerations for Automotive Vision Systems on a Fixed-Point DSP

    NASA Astrophysics Data System (ADS)

    Nikolić, Zoran

    In this chapter we evaluate numerical requirements for implementation of camera-based lateral position detection algorithms, such as lane keep assistant (LKA) and lane departure warning (LDW) on a fixed-point DSP. We first present methods that address the challenges and requirements of fixed-point design process. The flow proposed is targeted at converting C/C++ code with floating-point operations into C code with integer operations that can then be fed through the native C compiler for a fixed-point DSP. Advanced code optimization and an implementation by DSP-specific, fixed-point C code generation are introduced. We then demonstrate the conversion flow on tracking example (extended Kalman filter) using synthetically generated data, and we analyze trade-offs for algorithm implementation in fixed-point arithmetic. By using the techniques described in this chapter speed can be increased by a factor of up to 10 compared to floating-point emulation on fixed-point hardware.

  14. Complexation precedes phosphorylation for two-component regulatory system FixL/FixJ of Sinorhizobium meliloti.

    PubMed

    Tuckerman, J R; Gonzalez, G; Gilles-Gonzalez, M A

    2001-05-04

    The FixL/FixJ two-component regulatory system of Sinorhizobium meliloti controls the expression of nitrogen fixation genes in response to O2. When phosphorylated, the transcription factor FixJ binds to the nifA and fixK promoters in S. meliloti and induces expression of the corresponding genes, both of which encode key transcription activators. Phosphorylation of FixJ has been proposed to occur via the following cascade. The sensor kinase FixL reacts with ATP independently of FixJ, transferring a phosphoryl group to one of its own histidine residues. Dissociation of O2 from a heme-binding PAS domain in FixL greatly accelerates the rate of this autophosphorylation. The phosphoryl group is rapidly transferred from phospho-FixL to an aspartate residue on FixJ. The resulting phospho-FixJ is short-lived, due to a FixL-catalyzed hydrolysis of the aspartyl phosphate. Here, we show that phosphorylation of FixLJ, i.e. the complex of FixL with FixJ, is at least tenfold faster than the phosphorylation of FixL without FixJ. We further show that a phospho-FixJ phosphatase, thought to reside in FixL, is absent from this complex. These results indicate that FixLJ reacts with ATP as a unit and much more efficiently than FixL alone, and that autophosphorylation and phosphoryl transfer do not occur independently, in sequence, but rather in a closely coupled processive reaction. These findings highlight the possible influence of synergistic interactions of the regulatory components in two-component-system signal transduction.

  15. Parallel Fixed Point Implementation of a Radial Basis Function Network in an FPGA

    PubMed Central

    de Souza, Alisson C. D.; Fernandes, Marcelo A. C.

    2014-01-01

    This paper proposes a parallel fixed point radial basis function (RBF) artificial neural network (ANN), implemented in a field programmable gate array (FPGA) trained online with a least mean square (LMS) algorithm. The processing time and occupied area were analyzed for various fixed point formats. The problems of precision of the ANN response for nonlinear classification using the XOR gate and interpolation using the sine function were also analyzed in a hardware implementation. The entire project was developed using the System Generator platform (Xilinx), with a Virtex-6 xc6vcx240t-1ff1156 as the target FPGA. PMID:25268918

  16. Parallel fixed point implementation of a radial basis function network in an FPGA.

    PubMed

    de Souza, Alisson C D; Fernandes, Marcelo A C

    2014-09-29

    This paper proposes a parallel fixed point radial basis function (RBF) artificial neural network (ANN), implemented in a field programmable gate array (FPGA) trained online with a least mean square (LMS) algorithm. The processing time and occupied area were analyzed for various fixed point formats. The problems of precision of the ANN response for nonlinear classification using the XOR gate and interpolation using the sine function were also analyzed in a hardware implementation. The entire project was developed using the System Generator platform (Xilinx), with a Virtex-6 xc6vcx240t-1ff1156 as the target FPGA.

  17. Selective fixed drug eruption to amoxycillin.

    PubMed

    Arias, J; Férnandez-Rivas, M; Panadero, P

    1995-07-01

    A selective fixed drug eruption to amoxycillin but not other betalactam drugs is reported. Penicillins are the drugs most frequently implicated in immunological adverse reactions. The most important of these are allergic reactions where an IgE-mediated mechanism is well established. Other immunological mechanisms have been described in reactions, such as haemolytic anaemia, serum sickness, drug-induced nephritis, drug fever and contact dermatitis. Fixed drug eruption (FDE) is a type of drug-induced dermatosis, the immunopathogenesis of which remains unknown. FDE is an uncommon reaction to penicillin derivatives, and very few cases have been reported. We present a case of a selective FDE to amoxycillin (AX), with no reaction to other betalactam drugs. Although one similar case has been reported, the reactivity to other penicillin derivatives was not assessed.

  18. Fixed drug eruptions with intraoral presentation

    PubMed Central

    Srivastava, Rahul; Bihari, Manorama; Bhuvan, Jyoti; Saad, Ahmed

    2015-01-01

    Fixed-drug eruption (FDE) is an unusual and rare adverse drug reaction. This type of reaction is actually a delayed type of hypersensitivity reaction that occurs as lesions recurring at the same skin site due to repeated intake of an offending drug. Here is a case report of a 58-year-old male patient who developed intraoral FDEs after ingestion of the first dose of ornidazole. PMID:26097341

  19. Ergostatting and thermostatting at a fixed point

    NASA Astrophysics Data System (ADS)

    Hüffel, Helmuth; Ilijić, Saša

    2016-11-01

    We propose an innovative type of ergostats and thermostats for molecular dynamics simulations. A general class of active particle swarm models is considered, where any specific total energy (alternatively any specific temperature) can be provided at a fixed point of the evolution of the swarm. We identify the extended system feedback force of the Nosé-Hoover thermostat with the "internal energy" variable of active Brownian motion.

  20. Azithromycin induced bullous fixed drug eruption.

    PubMed

    Das, Anupam; Sancheti, Karan; Podder, Indrashis; Das, Nilay Kanti

    2016-01-01

    Fixed drug eruption (FDE) is a common type of drug eruption seen in skin clinics. It is characterized by solitary or multiple, round to oval erythematous patches with dusky red centers, some of which may progress to bulla formation. Bullous FDE may be caused by a number of drugs. We hereby describe a case of azithromycin-induced bullous FDE; to the best of our knowledge, this is the first such case being reported.

  1. Acemetacin-induced fixed drug eruption.

    PubMed

    Cebeci, Filiz; Yaşar, Şirin; Aytekin, Sema; Güneş, Pembegül

    2016-01-01

    Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other musculoskeletal disorders. We present a case of acemetacin-induced FDE in a 49-year-old woman. To the best of our knowledge, this is the second case report detailing clinical and histopathological findings of a patient with FDE caused by acemetacin.

  2. Fixed Wages, Layoffs, Unemployment Compensation, and Welfare.

    DTIC Science & Technology

    1976-10-01

    feasibility and optimality of alternative employment contracts. For the case where layoffs are prohibited, they demonstrate that both the fixed wage--constant...society’s point of view. In the case with layoffs , they show that the competitive mechanism leads to a less than optimal number of layoffs , and...demonstrate that unemployment insurance with less than complete experience rating lowers the cost of layoffs to the firm and encourages labor mobility. In the

  3. Zirconia in fixed prosthesis. A literature review

    PubMed Central

    Román-Rodríguez, Juan L.; Ferreiroa, Alberto; Solá-Ruíz, María F.; Fons-Font, Antonio

    2014-01-01

    Statement of problem: Evidence is limited on the efficacy of zirconia-based fixed dental prostheses. Objective: To carry out a literature review of the behavior of zirconium oxide dental restorations. Material and Methods: This literature review searched the Pubmed, Scopus, Medline and Cochrane Library databases using key search words “zirconium oxide,” “zirconia,” “non-metal restorations,” “ceramic oxides,” “veneering ceramic,” “zirconia-based fixed dental prostheses”. Both in vivo and in vitro studies into zirconia-based prosthodontic restoration behavior were included. Results: Clinical studies have revealed a high rate of fracture for porcelain-veneered zirconia-based restorations that varies between 6% and 15% over a 3- to 5-year period, while for ceramo-metallic restorations the fracture rate ranges between 4 and 10% over ten years. These results provoke uncertainty as to the long-term prognosis for this material in the oral medium. The cause of veneering porcelain fractures is unknown but hypothetically they could be associated with bond failure between the veneer material and the zirconia sub-structure. Key words:Veneering ceramic, zirconia-based ceramic restoration, crown, zirconia, tooth-supported fixed prosthesis. PMID:24596638

  4. Fixed points and FLRW cosmologies: Flat case

    NASA Astrophysics Data System (ADS)

    Awad, Adel

    2013-05-01

    We use a phase space approach to study possible consequences of fixed points in a single fluid flat Friedmann-Lemaître-Robertson-Walker (FLRW) models with pressure p(H), where H is the Hubble parameter. One of these consequences is that a fluid with a differentiable pressure, i.e., a finite adiabatic speed of sound, reaches a fixed point in an infinite time and has no finite-time singularities of types I, II, and III described by Nojiri, Odintsov, and Tsujikawa [Phys. Rev. D 71, 063004 (2005)]. It is impossible for such a fluid to cross the phantom divide in a finite time. We show that a divergent dp/dH, or the speed of sound, is a necessary but not sufficient condition for phantom crossing. We use pressure properties, such as asymptotic behavior and fixed points, to qualitatively describe the entire behavior of a solution in flat FLRW models. We discuss FLRW models with bulk viscosity η˜ρr, in particular, solutions for r=1 and r=1/4 cases, which can be expressed in terms of the Lambert-W function. The last solution behaves as either a nonsingular phantom fluid or a unified dark fluid. Using causality and stability constraints, we show that the universe must end as a de Sitter space. Relaxing the stability constraint leads to a de Sitter universe, an empty universe, or a turnaround solution that reaches a maximum size and then recollapses.

  5. RSRM nozzle fixed housing cooldown test

    NASA Technical Reports Server (NTRS)

    Bolieau, D. J.

    1989-01-01

    Flight 5 aft segments with nozzles were exposed to -17 F temperatures while awaiting shipment to KSC in February, 1989. No records were found which show that any previous nozzles were exposed to air temperatures as low as those seen by the Flight 5 nozzles. Thermal analysis shows that the temperature of the fixed housing, and forward and aft exit cone components dropped as low as -10 F. Structural analysis of the nozzles at these low temperatures show the forward and aft exit cone adhesive bonds to have a positive margin of safety, based on a 2.0 safety factor. These analyses show the normal and shear stresses in the fixed housing bond as low values. However, the hoop and meridinal stresses were predicted to be in the 4000 psi range; the failure stress allowable of EA913NA adhesive at -7 F. If the bonds did break in directions perpendicular to the surfaces, called bond crazing, no normal bond strength would be lost. Testing was conducted in two phases, showing that no degradation to the adhesive bonds occurred while the Flight 5 nozzles were subjected to subzero temperatures. The results of these tests are documented. Phase 1 testing cooled a full-scale RSRM insulated fixed housing to -13 F, with extensive bondline inspections. Phase 2 testing cooled the witness panel adhesive tensile buttions to -13 F, with failure strengths recorded before, during, and after the cooldown.

  6. LIQUID TARGET

    DOEpatents

    Martin, M.D.; Salsig, W.W. Jr.

    1959-01-13

    A liquid handling apparatus is presented for a liquid material which is to be irradiated. The apparatus consists essentially of a reservoir for the liquid, a target element, a drain tank and a drain lock chamber. The target is in the form of a looped tube, the upper end of which is adapted to be disposed in a beam of atomic particles. The lower end of the target tube is in communication with the liquid in the reservoir and a means is provided to continuously circulate the liquid material to be irradiated through the target tube. Means to heat the reservoir tank is provided in the event that a metal is to be used as the target material. The apparatus is provided with suitable valves and shielding to provide maximum safety in operation.

  7. Anisotropy of the transverse mode ultrasonic properties of fixed tendon and fixed myocardium.

    PubMed

    Hoffmeister, B K; Gehr, S E; Miller, J G

    1996-06-01

    This study investigates the influence of the fiber-reinforced nature of myocardium and tendon on the propagation of transverse mode ultrasonic waves. Formalin fixed specimens of normal human left ventricular cardiac muscle and bovine Achilles tendon were prepared for this study in such a way that transverse mode ultrasonic waves could be propagated perpendicular to the fiber axis of the tissue with the polarization oriented either parallel or perpendicular to the fiber axis. Measurements of velocity and attenuation were made at 3 MHz to assess the degree of anisotropy in these parameters for both tissues. Formalin fixed tendon exhibited a significant anisotropy whereas formalin fixed myocardium displayed a similar trend of more modest magnitude. Results of these measurements were used to compute two elastic stiffness coefficients for each tissue, yielding c44 = 37.2 MPa and c66 = 18.0 MPa for formalin fixed tendon, and c44 = 8.97 MPa and c66 = 8.45 MPa for formalin fixed myocardium. To validate this approach, additional studies were conducted to measure the transverse mode ultrasonic properties of silicone rubber and motor oil.

  8. Quorum Sensing in Nitrogen-Fixing Rhizobia

    PubMed Central

    González, Juan E.; Marketon, Melanie M.

    2003-01-01

    Members of the rhizobia are distinguished for their ability to establish a nitrogen-fixing symbiosis with leguminous plants. While many details of this relationship remain a mystery, much effort has gone into elucidating the mechanisms governing bacterium-host recognition and the events leading to symbiosis. Several signal molecules, including plant-produced flavonoids and bacterially produced nodulation factors and exopolysaccharides, are known to function in the molecular conversation between the host and the symbiont. Work by several laboratories has shown that an additional mode of regulation, quorum sensing, intercedes in the signal exchange process and perhaps plays a major role in preparing and coordinating the nitrogen-fixing rhizobia during the establishment of the symbiosis. Rhizobium leguminosarum, for example, carries a multitiered quorum-sensing system that represents one of the most complex regulatory networks identified for this form of gene regulation. This review focuses on the recent stream of information regarding quorum sensing in the nitrogen-fixing rhizobia. Seminal work on the quorum-sensing systems of R. leguminosarum bv. viciae, R. etli, Rhizobium sp. strain NGR234, Sinorhizobium meliloti, and Bradyrhizobium japonicum is presented and discussed. The latest work shows that quorum sensing can be linked to various symbiotic phenomena including nodulation efficiency, symbiosome development, exopolysaccharide production, and nitrogen fixation, all of which are important for the establishment of a successful symbiosis. Many questions remain to be answered, but the knowledge obtained so far provides a firm foundation for future studies on the role of quorum-sensing mediated gene regulation in host-bacterium interactions. PMID:14665677

  9. Robust extended target detection using nonlinear morphological operations

    NASA Astrophysics Data System (ADS)

    Chen, Hai-Wen; Volpe, Chris; Tarnowski, Michael; Snarski, Stephen

    2010-04-01

    The current bottleneck in wide area persistent surveillance missions is slow exploitation and analysis (real-time and forensic)by human analysts. We are currently developing an automated data exploitation system that can detect, track, and recognize targets and threats using computer vision. Here we present results from a newly developed target detection process. Depanding on target size, target detection can be divided in three detection classes: unresolved targets, small extended targets, and large extended targets. The Matched Filter (MF) method is currently a popular approach for unresolved target detection using IR focal plane arrays and EO (CCD) cameras and sensor detectors. The MF method is much more difficult to apply to to the extended target classes, since many different matched filters are needed to match the different target shapes and intensity profiles that can exist. The MF method does not adequately address non-fixed target shapes (e.g. walking or running human). We have developed an approach for robust target detection that can detect targets of different sizes and shapes (fixed/non-fixed) using a combination of image frame time-differencing, deep-thresholding, and target shape and size analysis with non-linear morphologial operations. Applications for gound vehicle detection under heavy urban background clutter will be presented.

  10. Gauge fixing in higher-derivative gravity

    NASA Astrophysics Data System (ADS)

    Bartoli, A.; Julve, J.; Sánchez, E. J.

    1999-07-01

    Linearized 4-derivative gravity with a general gauge-fixing term is considered. By a Legendre transform and a suitable diagonalization procedure it is cast into a second-order equivalent form where the nature of the physical degrees of freedom, the gauge ghosts, the Weyl ghosts and the intriguing `third ghosts', characteristic to higher-derivative theories, is made explicit. The symmetries of the theory and the structure of the compensating Faddeev-Popov ghost sector exhibit non-trivial peculiarities. The unitarity breaking negative-norm Weyl ghosts, already present in the diff-invariant theory, are out of the reach of the ghost cancellation BRST mechanism.

  11. Colligative Properties of Solutions: I. Fixed Concentrations

    NASA Astrophysics Data System (ADS)

    Alexander, Kenneth S.; Biskup, Marek; Chayes, Lincoln

    2005-05-01

    Using the formalism of rigorous statistical mechanics, we study the phenomena of phase separation and freezing-point depression upon freezing of solutions. Specifically, we devise an Ising-based model of a solvent--solute system and show that, in the ensemble with a fixed amount of solute, a macroscopic phase separation occurs in an interval of values of the chemical potential of the solvent. The boundaries of the phase separation domain in the phase diagram are characterized and shown to asymptotically agree with the formulas used in heuristic analyses of freezing-point depression. The limit of infinitesimal concentrations is described in a subsequent paper.

  12. New Tests of the Fixed Hotspot Approximation

    NASA Astrophysics Data System (ADS)

    Gordon, R. G.; Andrews, D. L.; Horner-Johnson, B. C.; Kumar, R. R.

    2005-05-01

    We present new methods for estimating uncertainties in plate reconstructions relative to the hotspots and new tests of the fixed hotspot approximation. We find no significant motion between Pacific hotspots, on the one hand, and Indo-Atlantic hotspots, on the other, for the past ~ 50 Myr, but large and significant apparent motion before 50 Ma. Whether this motion is truly due to motion between hotspots or alternatively due to flaws in the global plate motion circuit can be tested with paleomagnetic data. These tests give results consistent with the fixed hotspot approximation and indicate significant misfits when a relative plate motion circuit through Antarctica is employed for times before 50 Ma. If all of the misfit to the global plate motion circuit is due to motion between East and West Antarctica, then that motion is 800 ± 500 km near the Ross Sea Embayment and progressively less along the Trans-Antarctic Mountains toward the Weddell Sea. Further paleomagnetic tests of the fixed hotspot approximation can be made. Cenozoic and Cretaceous paleomagnetic data from the Pacific plate, along with reconstructions of the Pacific plate relative to the hotspots, can be used to estimate an apparent polar wander (APW) path of Pacific hotspots. An APW path of Indo-Atlantic hotspots can be similarly estimated (e.g. Besse & Courtillot 2002). If both paths diverge in similar ways from the north pole of the hotspot reference frame, it would indicate that the hotspots have moved in unison relative to the spin axis, which may be attributed to true polar wander. If the two paths diverge from one another, motion between Pacific hotspots and Indo-Atlantic hotspots would be indicated. The general agreement of the two paths shows that the former is more important than the latter. The data require little or no motion between groups of hotspots, but up to ~10 mm/yr of motion is allowed within uncertainties. The results disagree, in particular, with the recent extreme interpretation of

  13. Fixed Point Implementations of Fast Kalman Algorithms.

    DTIC Science & Technology

    1983-11-01

    fined point multiply. ve &geete a meatn ’C.- nero. variance N random vector s~t) each time weAfilter is said to be 12 Scaled if udae 8(t+11t0 - 3-1* AS...nl.v by bl ’k rn.b.) 20 AST iA C T ’Cnnin to .- a , o. a ide It .,oco ea ry and Idenuty by block number) In this paper we study scaling rules and round...realized in a -fast form that uses the so-called fast Kalman gain algorithm. The algorithm for the gain is fixed point. Scaling rules and expressions for

  14. Modafinil-induced Fixed Drug Eruption.

    PubMed

    Gaikwad, Girish Vasant; Dhuri, Chetali Vijay

    2012-10-01

    Modafinil is a stimulant drug widely used to promote wakefulness in a variety of psychiatric and neurological conditions. Modafinil-induced severe dermatologic reactions are uncommon but serious side effects. We report a patient who developed fixed drug eruption after exposure to a single dose of tablet modafinil. On assessment using the Naranjo scale, the score was five, which made us conclude that modafinil was the "probable" cause of the patient's adverse drug event. This case report highlights the need to be alert toward the emergence of dermatologic side effects among patients taking modafinil.

  15. [Fixed appliances current state of the art].

    PubMed

    Droschl, H; Eskici, A; Bantleon, H P; Muchitsch, A P

    1989-11-01

    Recent advances in fixed appliances are reviewed and discussed. These include cosmetically more appealing brackets (ceramic, lingual); new wires (nickel-titanium and titanium-molybdenum alloys); new biomechanical approaches (accurate computation of forces and torques according to Burstone resulting in the use of new mechanical concepts); experiences in the treatment of transplanted teeth made in the past 15 years; new approaches to the orthodontic finish (implementation of Andrews' "six keys to normal occlusion" with straight wires, accurate positioning of brackets, and gnathological positioners). Cases will be demonstrated.

  16. Facts & Figures: Answers to Frequently Asked Questions about Limited English Proficient (LEP) Students and Bilingual/ESL Programs, 1996-1997.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Office of Bilingual Education.

    In question and answer form, this document presents information about limited English proficient (LEP) students and programs for them in the New York City (New York) schools. City and state regulations govern the identification of LEP students and their selection for English as a second language (ESL) or bilingual programs. The Board of Education…

  17. Naturally fractured reservoirs: Optimized E and P strategies using a reaction-transport-mechanical simulator in an integrated approach. Annual report, 1996--1997

    SciTech Connect

    Hoak, T.; Jenkins, R.; Ortoleva, P.; Ozkan, G.; Shebl, M.; Sibo, W.; Tuncay, K.; Sundberg, K.

    1998-07-01

    The methodology and results of this project are being tested using the Andector-Goldsmith Field in the Permian Basin, West Texas. The study area includes the Central Basin Platform and the Midland Basin. The Andector-Goldsmith Field lies at the juncture of these two zones in the greater West Texas Permian Basin. Although the modeling is being conducted in this area, the results have widespread applicability to other fractured carbonate and other reservoirs throughout the world.

  18. Environmental radionuclide concentrations in the vicinity of the Calvert Cliffs Nuclear Power Plant and the Peach Bottom Atomic Power Station: 1996--1997. Final report

    SciTech Connect

    McLean, R.I.; Jones, T.S.

    1998-11-20

    The Maryland Power Plant Research Program monitors concentrations of natural, weapons, and power plant produced radionuclides in environmental samples collected from the Chesapeake Bay in the vicinity of the Calvert Cliffs Nuclear Power Plant (CCNPP) and from the Susquehanna River-Chesapeake Bay system in the vicinity of Peach Bottom Atomic Power Station (PBAPS). The purpose of this monitoring is to determine the fate, transport, and potential effects of power plant-produced radionuclides. This report contains a description of monitoring activities and data collected during the 1996 and 1997 calendar years. Radionuclide concentrations in shellfish, finfish, aquatic vegetation, and sediment were measured using high-resolution gamma spectrometry. Radionuclides in environmental samples originated from natural sources, historic atmospheric weapons testing, and normal operations of CCNPP and PBAPS.

  19. Descriptions of the Animas River-Cement Creek Confluence and Mixing Zone Near Silverton, Colorado, During the Late Summers of 1996-1997

    DTIC Science & Technology

    2005-01-01

    Descriptions of the Animas River-Cement Creek Confluence and Mixing Zone near Silverton , Colorado, during the Late Summers of 1996 and 1997 U.S...circum-neutral Animas River in a high-elevation region of the San Juan Mountains near Silverton , Colorado. Cement Creek is acidic and enriched in metals...Animas River drains an extensively mineralized caldera in the San Juan Mountains near Silverton , Colorado (Yager and Bove, 2002). This is an area of

  20. Stratospheric ozone loss in the 1996/1997 Arctic winter: Evaluation based on multiple trajectory analysis for double-sounded air parcels by ILAS

    NASA Astrophysics Data System (ADS)

    Terao, Yukio; Sasano, Yasuhiro; Nakajima, Hideaki; Tanaka, H. L.; Yasunari, Tetsuzo

    2002-12-01

    Quantitative chemical ozone loss rates and amounts in the Arctic polar vortex for the spring of 1997 are analyzed based on ozone profile data obtained by the Improved Limb Atmospheric Spectrometer (ILAS) using an extension of the Match technique. In this study, we calculated additional multiple trajectories and set very strict criteria to overcome the weakness of the satellite sensor data (lower vertical resolution and larger sampling air mass volume) and to identify more accurately a double-sounded air mass. On the average inside the inner edge of the vortex boundary (north of about 70°N equivalent latitude), the local ozone loss rate was 50-80 ppbv/day at the maximum during late February between the levels of 450 and 500 K potential temperatures. The integrated ozone loss during February to March reached 2.0 ± 0.1 ppmv at 475-529 K levels, and the column ozone loss between 400 and 600 K during the 2 months was 96 ± 0.3 DU. Using a relative potential vorticity (rPV) scale, the vortex was divided into some rPV belts, and it was shown that the magnitude of the ozone loss increased gradually toward the vortex center from the edge. The maximum ozone loss rate of 6.0 ± 0.6 ppbv/sunlit hour near the vortex center was higher than near the vortex edge by a factor of 2-3. When we expanded the area of interest to include all the data obtained inside the vortex edge (north of about 65°N equivalent latitude), the local ozone loss rate was about 50 ppbv/day at the maximum. This value is slightly larger than that estimated by the Match analysis using ozonesondes for the same winter by ˜10 ppbv/day. Temperature histories of double-sounded air parcels indicated that the extreme ozone loss in the innermost part of the vortex was observed when the air parcel experienced temperatures below TNAT during the two soundings and had experienced temperatures near Tice in the 10 days prior to the first sounding. These facts suggest that the high ozone loss rate deep inside the vortex in the 1997 Arctic early spring correlates with the presence of type Ia polar stratospheric clouds (PSCs).

  1. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  2. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  3. GEO space debris flux determination based on earth-fixed coordinate system

    NASA Astrophysics Data System (ADS)

    Dongfang, Wang; Baojun, Pang; Weike, Xiao

    2017-01-01

    An analysis is performed on the space debris flux determination of geosynchronous (GEO) orbit based on earth-fixed coordinate system. As part of the examination, flux contribution from different components of space debris is presented here in order to clarify the linkage between orbital characteristic and resulting flux distribution. The analysis of GEO flux determination based on earth-fixed coordinate system reveals several new insights: 1) Near the GEO equatorial plane, average flux mainly centralizes in two azimuth ranges: the higher priority one, local azimuth close to±90°, mainly contributed from objects with relatively larger inclination; the lower priority one, local azimuth close to 0°, mainly contributed from objects with relatively smaller inclination. 2) Impact flux against geostationary satellites is not unified by longitude. Longitude-dependent flux determination based on earth-fixed frame reveals that impact flux against geostationary satellite near the geopotential wells (105°W and 75°E longitude zones) is about two to three times larger than average. 3) The comparison of flux determination against certain targets based on earth-fixed coordinate system and inertially-fixed coordinate system shows significant difference.

  4. Detection in fixed and random noise in foveal and parafoveal vision explained by template learning

    NASA Technical Reports Server (NTRS)

    Beard, B. L.; Ahumada, A. J. Jr; Watson, A. B. (Principal Investigator)

    1999-01-01

    Foveal and parafoveal contrast detection thresholds for Gabor and checkerboard targets were measured in white noise by means of a two-interval forced-choice paradigm. Two white-noise conditions were used: fixed and twin. In the fixed noise condition a single noise sample was presented in both intervals of all the trials. In the twin noise condition the same noise sample was used in the two intervals of a trial, but a new sample was generated for each trial. Fixed noise conditions usually resulted in lower thresholds than twin noise. Template learning models are presented that attribute this advantage of fixed over twin noise either to fixed memory templates' reducing uncertainty by incorporation of the noise or to the introduction, by the learning process itself, of more variability in the twin noise condition. Quantitative predictions of the template learning process show that it contributes to the accelerating nonlinear increase in performance with signal amplitude at low signal-to-noise ratios.

  5. Critical two-dimensional Ising model with free, fixed ferromagnetic, fixed antiferromagnetic, and double antiferromagnetic boundaries.

    PubMed

    Wu, Xintian; Izmailyan, Nickolay

    2015-01-01

    The critical two-dimensional Ising model is studied with four types boundary conditions: free, fixed ferromagnetic, fixed antiferromagnetic, and fixed double antiferromagnetic. Using bond propagation algorithms with surface fields, we obtain the free energy, internal energy, and specific heat numerically on square lattices with a square shape and various combinations of the four types of boundary conditions. The calculations are carried out on the square lattices with size N×N and 30

  6. Fixed Drug Eruption due to Achiote Dye

    PubMed Central

    Tattersall, Ian; Reddy, Bobby Y.

    2016-01-01

    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing. PMID:26933409

  7. [Fiber-reinforced composite in fixed prosthodontics].

    PubMed

    Pilo, R; Abu Rass, Z; Shmidt, A

    2010-07-01

    Fiber reinforced composite (FRC) is composed of resin matrix and fibers filler. Common types of fibers: polyethylene, carbon and glass. Fibers can be continuous and aligned, discontinuous and aligned, discontinuous and randomly oriented. The architecture of the fibers is unidirectional, woven or braided. The two main types are: dry fibers or impregnated. Inclusion of fibers to resin composite increased its average flexural strength in 100-200 MPa. FRC can be utilized by the dentist in direct approach (splinting, temporary winged bridge) or indirect approach (laboratory made fixed partial denture). Laboratory fixed partial denture (FPD) is made from FRC substructure and Hybrid/Microfill particulate composite veneer. Main indications: interim temporary FPD or FPD in cases of questionable abutment teeth, in aesthetic cases where All Ceram FPD is not feasible. Retention is attained by adhesive cementation to minimally prepared teeth or to conventionally prepared teeth; other options are inlay-onlay bridges or hybrid bridges. Contraindications are: poor hygiene, inability to control humidity, parafunction habits, and more than two pontics. Survival rate of FRC FPD over 5 years is 75%, lower compared to porcelain fused to metal FPD which is 95%. Main reasons for failure are: fracture of framework and delamination of the veneer. Part of the failures is repairable.

  8. Fragmentation functions beyond fixed order accuracy

    NASA Astrophysics Data System (ADS)

    Anderle, Daniele P.; Kaufmann, Tom; Stratmann, Marco; Ringer, Felix

    2017-03-01

    We give a detailed account of the phenomenology of all-order resummations of logarithmically enhanced contributions at small momentum fraction of the observed hadron in semi-inclusive electron-positron annihilation and the timelike scale evolution of parton-to-hadron fragmentation functions. The formalism to perform resummations in Mellin moment space is briefly reviewed, and all relevant expressions up to next-to-next-to-leading logarithmic order are derived, including their explicit dependence on the factorization and renormalization scales. We discuss the details pertinent to a proper numerical implementation of the resummed results comprising an iterative solution to the timelike evolution equations, the matching to known fixed-order expressions, and the choice of the contour in the Mellin inverse transformation. First extractions of parton-to-pion fragmentation functions from semi-inclusive annihilation data are performed at different logarithmic orders of the resummations in order to estimate their phenomenological relevance. To this end, we compare our results to corresponding fits up to fixed, next-to-next-to-leading order accuracy and study the residual dependence on the factorization scale in each case.

  9. An airborne intensive care facility (fixed wing).

    PubMed

    Gilligan, J E; Goon, P; Maughan, G; Griggs, W; Haslam, R; Scholten, A

    1996-04-01

    A fixed-wing aircraft (Beechcraft KingAir B200 C) fitted as an airborne intensive care facility is described. It completed 2000 missions from 1987-1992 for distances up to 1300 km. Features include: 1. Space for carriage of two stretchers, medical cabin crew of up to five persons and equipment and two-pilot operation if necessary. A third stretcher may be carried in emergencies. 2. Two CARDIOCAP (TM) fixed monitors for ECG, invasive and noninvasive pressures pulse oximetry and end-tidal C02 plus SIEMENS 630(TM)/PROPAQ(TM) compact monitors for the ground transport phase of missions, or the total duration. 3. A medical oxygen reservoir of 4650 litres sufficient for two patients on IPPV with FiO2 = 1.0 for a four-hour trip. The medical suction system is powered from the engine or a vacuum pump. 4. Other medical equipment and drugs in portable packs, for ground transport and resuscitation needs and for replenishment by nursing staff at the parent hospitals. 5. Stretchers compatible with helicopter and road ambulance vehicles used. 6. A stretcher loading device energized from the aircraft, operating through a wide (cargo) door. 7. Provision of 24Ov AC (alternating current) and 28v DC (direct current) electrical energy. 8. Pressurization and climate control. 9. Satisfactory aviation performance for conditions encountered, with single-pilot operation.

  10. Fixed Drug Eruption due to Achiote Dye.

    PubMed

    Tattersall, Ian; Reddy, Bobby Y

    2016-01-01

    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing.

  11. Fixed film phosphorus removal--flexible enough?

    PubMed

    Rogalla, F; Johnson, T L; McQuarrie, J

    2006-01-01

    While biological phosphorus removal (BPR) has been practised for 30 years, up to recently it has been restricted mainly to activated sludge processes, with the corresponding need for large basin volumes. Yet, research with biofilm reactors showed that the principle of alternate anaerobic and aerated conditions was applicable to fixed bacteria by changing the conditions in time rather than in space. Attached growth enhanced biological phosphorus removal (EBPR) systems are attractive because of their compactness and capability to retain high biomass levels. However, the phosphorus extraction depends on backwashes to enhance the phosphorus-rich attached biomass, and correct control of unsteady effluent quality created by frequently modified process conditions. Accordingly, EBPR remains a challenging task in terms of combining nitrogen and phosphorus removal using attached growth systems. Nevertheless, a combination of activated sludge and biofilm carriers, in the integrated fixed-film activated sludge system, provides treatment opportunities not readily available using suspended growth systems. Current practice is only at the beginning of exploiting the full potential of this combination, but the first full-scale results show that compact tankage and low nutrient results based on biological principles are possible.

  12. Fixing Gauge Redundancies in Quantum Gravity

    NASA Astrophysics Data System (ADS)

    Weinberg, Sean Jason

    Evidence has accumulated that descriptions of systems in quantum gravity depend strongly on various choices of gauge-fixing including a choice of "reference frame." We discuss several explicit examples of this reference frame dependence and, in doing so, clarify a number of general features of quantum gravity including the thermodynamics of spacetime, the holographic principle, and black hole complementarity. Our discussion focuses on two superficially independent subjects. The first of these is that of holographic screens. These are codimension-one surfaces that are preferred from the perspective of the holographic principle. They are generated by a choice of null foliation and, in particular, can be fixed by the light cones of a worldline. We will study a class of holographic screens called past and future holographic screens and strengthen a recently proven area law for these surfaces. We then introduce a definition of holographic entanglement entropy associated with past and future holographic screens and, in doing so, provide new evidence for the importance of screens in quantum gravity. Our second major emphasis is on the black hole information paradox and the firewall paradox. We give a set of hypotheses for the microscopic structure of black holes that appears to be self-consistent and admit a smooth horizon despite the AMPS arguments. Our model relies on the principle that the quantum information associated with spacetime is both delocalized and reference frame dependent.

  13. Experimental Study on Nonlinear Vibrations of Fixed-Fixed Curved Beams

    NASA Astrophysics Data System (ADS)

    Kumar, Ajay; Patel, B. P.

    2016-07-01

    Nonlinear dynamic behavior of fixed-fixed shallow and deep curved beams is studied experimentally using non-contact type of electromagnetic shaker and acceleration measurements. The frequency response obtained from acceleration measurements is found to be in fairly good agreement with the computational response. The travellingwave phenomenon along with participation of higher harmonics and softening nonlinearity are observed. The experimental results on the internal resonance of curved beams due to direct excitation of anti-symmetric mode are reported for the first time. The deep curved beam depicts chaotic response at higher excitation amplitude.

  14. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  15. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  16. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  17. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  18. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  19. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  20. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  1. 29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet...

  2. 29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet...

  3. 29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet...

  4. 29 CFR 1910.161 - Fixed extinguishing systems, dry chemical.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Fixed extinguishing systems, dry chemical. 1910.161 Section... § 1910.161 Fixed extinguishing systems, dry chemical. (a) Scope and application. This section applies to all fixed extinguishing systems, using dry chemical as the extinguishing agent, installed to meet...

  5. 33 CFR 118.65 - Lights on fixed bridges.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on fixed bridges. 118.65... LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable... range of two green lights, and each margin of each navigable channel will be marked by a red...

  6. 12 CFR 701.36 - FCU ownership of fixed assets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... earnings. Unless otherwise specified by the regional director, the credit union may make future acquisition of fixed assets only if the aggregate all of such future investments in fixed assets does not exceed... with its proposed investment in fixed assets. The investment, and any future investments in...

  7. 47 CFR 25.277 - Temporary fixed earth station operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Temporary fixed earth station operations. 25... SERVICES SATELLITE COMMUNICATIONS Technical Operations § 25.277 Temporary fixed earth station operations. (a) When an earth station in the Fixed-Satellite Service is to remain at a single location for...

  8. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  9. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  10. 29 CFR 1910.160 - Fixed extinguishing systems, general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... sprinkler systems which are covered by § 1910.159. (2) This section also applies to fixed systems not... 29 Labor 5 2010-07-01 2010-07-01 false Fixed extinguishing systems, general. 1910.160 Section 1910... § 1910.160 Fixed extinguishing systems, general. (a) Scope and application. (1) This section applies...

  11. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Coordination with fixed microwave service. 15... Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service. (a... Private Operational-Fixed Microwave Service (OFS) operating under part 101 of this chapter to...

  12. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Coordination with fixed microwave service. 15... Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service. (a... Private Operational-Fixed Microwave Service (OFS) operating under part 101 of this chapter to...

  13. 47 CFR 25.277 - Temporary fixed earth station operations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Temporary fixed earth station operations. 25... SERVICES SATELLITE COMMUNICATIONS Technical Operations § 25.277 Temporary fixed earth station operations. (a) When an earth station in the Fixed-Satellite Service is to remain at a single location for...

  14. 47 CFR 25.277 - Temporary fixed earth station operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Temporary fixed earth station operations. 25... SERVICES SATELLITE COMMUNICATIONS Technical Operations § 25.277 Temporary fixed earth station operations. (a) When an earth station in the Fixed-Satellite Service is to remain at a single location for...

  15. 47 CFR 25.277 - Temporary fixed earth station operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Temporary fixed earth station operations. 25... SERVICES SATELLITE COMMUNICATIONS Technical Operations § 25.277 Temporary fixed earth station operations. (a) When an earth station in the Fixed-Satellite Service is to remain at a single location for...

  16. 47 CFR 25.277 - Temporary fixed earth station operations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Temporary fixed earth station operations. 25... SERVICES SATELLITE COMMUNICATIONS Technical Operations § 25.277 Temporary fixed earth station operations. (a) When an earth station in the Fixed-Satellite Service is to remain at a single location for...

  17. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., general. (a) Fixed carbon dioxide or halogenated extinguishing systems must be installed to protect the... fixed extinguishing system must be of an approved carbon dioxide or halogenated type and installed to... tank spaces are so open to the atmosphere as to make the use of a fixed system ineffective; (2)...

  18. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., general. (a) Fixed carbon dioxide or halogenated extinguishing systems must be installed to protect the... fixed extinguishing system must be of an approved carbon dioxide or halogenated type and installed to... tank spaces are so open to the atmosphere as to make the use of a fixed system ineffective; (2)...

  19. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  20. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  1. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  2. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  3. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  4. Review of the inverse scattering problem at fixed energy in quantum mechanics

    NASA Technical Reports Server (NTRS)

    Sabatier, P. C.

    1972-01-01

    Methods of solution of the inverse scattering problem at fixed energy in quantum mechanics are presented. Scattering experiments of a beam of particles at a nonrelativisitic energy by a target made up of particles are analyzed. The Schroedinger equation is used to develop the quantum mechanical description of the system and one of several functions depending on the relative distance of the particles. The inverse problem is the construction of the potentials from experimental measurements.

  5. Auditory target detection in reverberation

    NASA Astrophysics Data System (ADS)

    Zurek, Patrick M.; Freyman, Richard L.; Balakrishnan, Uma

    2004-04-01

    Measurements and theoretical predictions of auditory target detection in simulated reverberant conditions are reported. The target signals were pulsed 13-octave bands of noise and the masker signal was a continuous wideband noise. Target and masker signals were passed through a software simulation of a reverberant room with a rigid sphere modeling a listener's head. The location of the target was fixed while the location of the masker was varied in the simulated room. Degree of reverberation was controlled by varying the uniform acoustic absorption of the simulated room's surfaces. The resulting target and masker signals were presented to the listeners over headphones in monaural-left, monaural-right, or binaural listening modes. Changes in detection performance in the monaural listening modes were largely predictable from the changes in target-to-masker ratio in the target band, but with a few dB of extra masking in reverberation. Binaural detection performance was generally well predicted by applying Durlach's [in Foundations of Modern Auditory Theory (Academic, New York, 1972)] equalization-cancellation theory to the direct-plus-reverberant ear signals. Predictions in all cases were based on a statistical description of room acoustics and on acoustic diffraction by a sphere. The success of these detection models in the present well-controlled reverberant conditions suggests that they can be used to incorporate listening mode and source location as factors in speech-intelligibility predictions.

  6. Low crosstalk optical hierarchical authentication with a fixed random phase lock based on two beams interference

    NASA Astrophysics Data System (ADS)

    Lu, Dajiang; He, Wenqi; Peng, Xiang

    2015-09-01

    We propose a novel method to achieve the purpose of hierarchical authentication based on two beams interference. In this method, different target images indicating different authentication levels are analytically encoded into corresponding phase-only masks (phase keys) and amplitude-only masks (amplitude keys) with the help of a random phase mask, which is created in advance and acts as the fixed lock of this authentication system. For the authentication process, a legal user can obtain a specified target image at the output plane if his/her phase key, and amplitude key, which should be settled close against the fixed internal phase lock, are respectively illuminated by two coherent beams. By comparing the target image with all the standard certification images in the database, the system can thus verify the user's identity. In simple terms, this system can not only confirm the legality of a user but also distinguish his/her identity level. Moreover, in despite of the internal phase lock of this system being fixed, the crosstalk between different pairs of keys hold by different users is low. Theoretical analysis and numerical simulation are both provided to demonstrate the validity of this method.

  7. Breaking the fixed-arrival-time restriction in reaching movements of neural prosthetic devices.

    PubMed

    Srinivasan, Lakshminarayan; da Silva, Marco

    2011-06-01

    We routinely generate reaching arm movements to function independently. For paralyzed users of upper extremity neural prosthetic devices, flexible, high-performance reaching algorithms will be critical to restoring quality-of-life. Previously, algorithms called real-time reach state equations (RSE) were developed to integrate the user's plan and execution-related neural activity to drive reaching movements to arbitrary targets. Preliminary validation under restricted conditions suggested that RSE might yield dramatic performance improvements. Unfortunately, real-world applications of RSE have been impeded because the RSE assumes a fixed, known arrival time. Recent animal-based prototypes attempted to break the fixed-arrival-time assumption by proposing a standard model (SM) that instead restricted the user's movements to a fixed, known set of targets. Here, we leverage general purpose filter design (GPFD) to break both of these critical restrictions, freeing the paralyzed user to make reaching movements to arbitrary target sets with various arrival times and definitive stopping. In silico validation predicts that the new approach, GPFD-RSE, outperforms the SM while offering greater flexibility. We demonstrate the GPFD-RSE against SM in the simulated control of an overactuated 3-D virtual robotic arm with a real-time inverse kinematics engine.

  8. Settling of fixed erythrocyte suspension droplets

    NASA Technical Reports Server (NTRS)

    Omenyi, S. N.; Snyder, R. S.

    1983-01-01

    It is pointed out that when particles behave collectively rather than individually, the fractionation of micron-size particles on the basis of size, density, and surface characteristics by centrifugation and electrophoresis is hindered. The formation and sedimentation of droplets containing particles represent an extreme example of collective behavior and pose a major problem for these separation methods when large quantities of particles need to be fractionated. Experiments are described that measure droplet sizes and settling rates for a variety of particles and droplets. Expressions relating the particle concentration in a drop to measurable quantities of the fluids and particles are developed. The number of particles in each droplet is then estimated, together with the effective droplet density. Red blood cells from different animals fixed in glutaraldehyde provide model particle groups.

  9. Secure Computation with Fixed-Point Numbers

    NASA Astrophysics Data System (ADS)

    Catrina, Octavian; Saxena, Amitabh

    Secure computation is a promising approach to business problems in which several parties want to run a joint application and cannot reveal their inputs. Secure computation preserves the privacy of input data using cryptographic protocols, allowing the parties to obtain the benefits of data sharing and at the same time avoid the associated risks. These business applications need protocols that support all the primitive data types and allow secure protocol composition and efficient application development. Secure computation with rational numbers has been a challenging problem. We present in this paper a family of protocols for multiparty computation with rational numbers using fixed-point representation. This approach offers more efficient solutions for secure computation than other usual representations.

  10. Meprobamate-induced fixed drug eruption.

    PubMed

    Zaïem, Ahmed; Kaabi, Widd; Badri, Talel; Lakhoua, Ghozlane; Sahnoun, Rym; Kastalli, Sarrah; Daghfous, Riadh; Lakhal, Mohamed; El Aidli, Sihem

    2014-01-01

    Meprobamate is usually a safe drug prescribed for anxiety disorders. Fixed drug eruption (FDE) is an exceptional cutaneous adverse effect of this drug. We report a case of FDE induced by meprobamate with positive patch test. A 22-year-old woman was prescribed for depression meprobamate, aceprometazine, valpromide and lorazepam. On the second day of treatment, the patient presented red erythematous and pruriginous plaques in the limbs and the face. After stopping the previous treatment, the patient's lesions resolved completely within 3 weeks with residual pigmentation. One month later, patch tests were performed and were positive to meprobamate. Exceptional cases of FDE were reported in literature with meprobamate. None has reported the use of patch test to confirm the diagnosis.

  11. Galvanic gold plating for fixed dental prosthesis.

    PubMed

    Ozcelik, Tuncer Burak; Yilmaz, Burak

    2013-07-01

    Metal ceramic partial fixed dental prostheses have been commonly used for the replacement of missing teeth for many years. Because of an increase in the price of gold, base metal alloys have been the choice of alloy for the fabrication of metal ceramic restorations in many dental clinics. Some major disadvantages of base metals are their corrosion and the dark coloration they may cause at the crown margins. This article describes a galvanic gold-plating technique, which is used to minimize corrosion and improve the esthetics of metal ceramic restorations fabricated with Cr-Co base metal alloys. This technique involves the deposition of a 6 μm to 8 μm 24 K gold layer directly onto the Cr-Co cast prosthesis framework. The technique improves metal surface properties, making them more biocompatible and usable, however, requires additional equipment and experienced laboratory technicians. Clinical studies should be performed to corroborate the long term success of this technique.

  12. Fixed drug eruption due to levocetirizine.

    PubMed

    Jhaj, Ratinder; Asati, Dinesh Prasad; Chaudhary, Deepa

    2016-01-01

    A fixed drug eruption (FDE) is a cutaneous adverse drug reaction due to Type IV or delayed cell-mediated hypersensitivity. Antihistamines, which antagonize the action of histamine during an allergic reaction by blocking the H1 histamine receptors, are used routinely for the treatment of various allergic disorders such as urticaria, eczemas, and also in itchy lesions of skin like scabies. Levocetirizine, an active (R)-enantiomer of cetirizine, is a newer or second generation antihistamine, with more specific actions and fewer side effects, including cutaneous reactions. FDE due to levocetirizine as well as with cetirizine are rare. We report a case of levocetirizine induced FDE in a 49-year-old male patient with scabies. The patient had a history of cetirizine induced FDE in the past.

  13. Ursodeoxycholic acid induced generalized fixed drug eruption.

    PubMed

    Ozkol, Hatice Uce; Calka, Omer; Dulger, Ahmet Cumhur; Bulut, Gulay

    2014-09-01

    Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3α,7β-dihydroxy-5β-cholanic acid) is used for the treatment of cholestatic liver diseases. Some side effects may be observed, such as diarrhea, dyspepsia, pruritus and headaches. We encountered only three cases of lichenoid reaction regarding the use of UDCA among previous studies. In this article, we reported a generalized FDE case related to UDCA intake in a 59-year-old male patient with cholestasis for the first time in the literature.

  14. Fixed drug eruption due to clarithromycin.

    PubMed

    Malkarnekar, Santoshi Balkrishna; Naveen, L

    2013-10-01

    Fixed drug eruption (FDE) is an unusual adverse effect of any drug, especially antibiotics like clarithromycin. Herein we report a case of clarithromycin induced FDE in a 30-year-old man who presented with recurrent erythematous and pruritic cutaneous lesions on the lower lip, right hand and left thigh. The lesions were initially misdiagnosed as lichen planus and treated with topical steroids. Each recurrence was at the same site and the lesions faded within 2 weeks leaving behind violacceous pigmentation. All the cutaneous lesions were reproduced following an oral provocation test thus confirming the diagnosis of clarithromycin induced FDE, which is a rare occurrence. When it does occur, it is often misdiagnosed, so physicians should be aware of this condition in order to prevent future recurrences as it causes a lot of cosmetic and physical discomfort to the patient.

  15. New SMU Gallium Fixed-Point Cells

    NASA Astrophysics Data System (ADS)

    Ranostaj, Juraj; Ďuriš, Stanislav; Knorová, Renáta; Kaskötö, Mariana; Vyskočilová, Irena

    2011-08-01

    In the framework of the European research project EURAMET 732, the Slovak Institute of Metrology (SMU) built three primary gallium fixed-point cells of different designs. The cells are designed for the calibration of the long-stem SPRT. In regard to the procedure commonly used at SMU when realizing the gallium point, the cells are designed for use in a stirred liquid bath. This article provides information about the cell designs, materials used, method of filling, and results of the performed experiments. The experiments were focused on the study of the cells' metrological characteristics, some effects that could influence the melting-point temperature and the effect of the melted metal fraction on the immersion profile. New cells were compared with the SMU reference gallium cell.

  16. Fixed drug eruption due to levocetirizine

    PubMed Central

    Jhaj, Ratinder; Asati, Dinesh Prasad; Chaudhary, Deepa

    2016-01-01

    A fixed drug eruption (FDE) is a cutaneous adverse drug reaction due to Type IV or delayed cell-mediated hypersensitivity. Antihistamines, which antagonize the action of histamine during an allergic reaction by blocking the H1 histamine receptors, are used routinely for the treatment of various allergic disorders such as urticaria, eczemas, and also in itchy lesions of skin like scabies. Levocetirizine, an active (R)-enantiomer of cetirizine, is a newer or second generation antihistamine, with more specific actions and fewer side effects, including cutaneous reactions. FDE due to levocetirizine as well as with cetirizine are rare. We report a case of levocetirizine induced FDE in a 49-year-old male patient with scabies. The patient had a history of cetirizine induced FDE in the past. PMID:27440959

  17. Fixed Eigenvector Analysis of Thermographic NDE Data

    NASA Technical Reports Server (NTRS)

    Cramer, K. Elliott; Winfree, William P.

    2011-01-01

    Principal Component Analysis (PCA) has been shown effective for reducing thermographic NDE data. This paper will discuss an alternative method of analysis that has been developed where a predetermined set of eigenvectors is used to process the thermal data from both reinforced carbon-carbon (RCC) and graphiteepoxy honeycomb materials. These eigenvectors can be generated either from an analytic model of the thermal response of the material system under examination, or from a large set of experimental data. This paper provides the details of the analytic model, an overview of the PCA process, as well as a quantitative signal-to-noise comparison of the results of performing both conventional PCA and fixed eigenvector analysis on thermographic data from two specimens, one Reinforced Carbon-Carbon with flat bottom holes and the second a sandwich construction with graphite-epoxy face sheets and aluminum honeycomb core.

  18. Report nixes Geritol fix for global warming

    SciTech Connect

    Roberts, L.

    1991-09-27

    Several years ago John Martin of the Moss Landing Marine Laboratory in California suggested a quick fix to the greenhouse problem: dump iron into the Southern Ocean near Antarctica. That, he said, would trigger a massive bloom of the ocean's microscopic plants, which in turn would suck carbon dioxide out of the atmosphere and help reduce global warming. His idea ignited a firestorm of controversy that rages on today. While the idea quickly won supporters - including some prominent members of the National Academy of Sciences - much of the oceanographic community was incensed, arguing that you don't tinker with a perfectly health ecosystem to clean up humanity's mess. Now the American Society of Limnology and Oceanography (ASLO) has a report that represents the views of much of the oceanographic community. In the report, released in late summer, ASLO trounces the idea of fertilizing the oceans with iron as a greenhouse fix, as expected. But in an unexpected twist, the society endorses a small-scale experiment in which iron would be added to the open ocean. The idea isn't to engineer the oceans, but to test the hypothesis that might answer one of the longstanding puzzles in biological oceanography: why do the phytoplankton of the Southern Ocean, as well as those in parts of the subarctic and equatorial Pacific, grow so poorly, even though the waters are rich in nutrients such as phosphorus and nitrogen The answer could shed light not only on how the food web operates, but on the global carbon cycle as well.

  19. Do foliar endophytic bacteria fix nitrogen?

    NASA Astrophysics Data System (ADS)

    Kueppers, L. M.; Moyes, A. B.; Frank, C.; Pett-Ridge, J.; Carper, D.; Vandehey, N.; O'Neil, J.; Dekas, A.

    2015-12-01

    Endophytic microorganisms - bacteria and fungi that live inside healthy plant tissue - are a relatively unexplored source of functional diversity in natural ecosystems. Prior to modern sequencing technology, detecting uncultured endophytic bacteria and assessing their putative functions was challenging. However, recent work has revealed a remarkable diversity of as yet non-culturable endophytic taxa and is beginning to identify functional roles within plant microbiomes. We recently examined bacterial communities in the foliage of a long-lived, high-elevation conifer species, limber pine (Pinus flexilis), and discovered a community strongly dominated by acetic acid bacteria (Acetobacteraceae), with several taxa closely related to known nitrogen fixers. Given limber pine's status as a pioneer species that is able to grow in low fertility soils, we hypothesized that this bacterial community has a potential functional role in fixing atmospheric nitrogen, providing a source of this limiting nutrient to the host tree. We used the radioisotope 13N2 to confirm that N2 rapidly diffuses into pine needles, where it could potentially be fixed. With an acetylene reduction assay we confirmed nitrogenase enzyme activity inside excised twigs 4 times over a growing season, and estimate potential rates of N2 fixation at 0.1 nmol N2 g needle-1 hr-1. Scaled to the stand level, this N input could be on the order of ~20 mg N m-2 d-1 over a growing season. While these rates are low, the long lifespan of individual trees (~1000 years) makes them biologically meaningful. Still, measured rates of acetylene reduction and bulk 15N2 incorporation are quite variable in space and time. Much work remains to better characterize the plant-microbial interactions in this system, including the rates of nitrogen fixation and their variability over the growing season, across edaphic conditions, among host species, and through plant development; and to determine which community members are responsible

  20. Tackling Targets.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    This document is designed to help British training and enterprise councils (TECs) and further education (FE) colleges develop and implement strategies for achieving the National Targets for Education and Training (NTET), which were developed by the Confederation of British Industry in 1992 and endorsed by the British government. The findings from…

  1. On Target.

    ERIC Educational Resources Information Center

    Barbalich, Andrea

    1991-01-01

    Campus public relations professionals offer advice for improving the effectiveness of public relations efforts by (1) setting behavioral goals; (2) targeting audiences carefully; (3) focusing appeals by making messages explicit; (4) connecting the public relations message with larger societal issues; and (5) reaching internal as well as external…

  2. Process window aware layout optimization using hot spot fixing system

    NASA Astrophysics Data System (ADS)

    Kobayashi, Sachiko; Kyoh, Suigen; Kotani, Toshiya; Inoue, Soichi

    2007-03-01

    spot, complying with the design rule. The design modification process is verified with design-rule checker (DRC) and process simulation to confirm hot spot elimination without side effect. In this work, HSF is implemented in the design flow for various logic devices of 65 nm node. We extend modification target layers to multiple critical layers, including active area, poly, local metal wire and intermediate metal wire. The feasibility of the provided HSF system has been studied by applying it to around one hundred data of various sizes with respect to pattern fixing rate and turn around time (TAT). Moreover, process margin expansion including depth of focus (DOF) and exposure latitude (EL), in small layout was verified using process simulation and also by experimental results, namely, scanning electron microscope (SEM) images of focus exposure matrix. The detailed results are shown in the paper.

  3. Target assembly

    DOEpatents

    Lewis, Richard A.

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  4. Oral health with fixed appliances orthodontics.

    PubMed

    Frank, Wilhelm; Pfaller, Karin; Konta, Brigitte

    2008-03-11

    Orthodontic treatment represents an important fraction in dental interventions. According to other medical methods the question for scientific evidence for the effectiveness of these treatments arises. The question of the effectiveness is connected with the question what is understood as an effect. In principle, the effect of the intervention is understood on the basis of the occlusion or dental health, what disregards further functions of oral health. The generalization to oral health is therefore a necessary consideration in science now. If one appreciates this further development, then there is no one single randomised study available which examines the long-term effect of the orthodontic intervention or for the effects on the oral health.The question, whether the application of a fixed appliance in an orthodontic treatment causes a long-term improvement in oral health, cannot be answered at the present time. The scientific status is the definition of oral health at present. Also the question, whether in the long run the dental health can be improved by fixed appliances cannot be answered with a quality usually achieved by evidence-based medicine. Whether correction of a dental malposition is an effective prerequisite for the preservation of the natural teeth, cannot be answered. There is no generalizing study with sufficient scientific background for Europe or Germany to this topic. The risk for caries cannot be quantified. Caries is identified as a central topic in general but due to numerous factors influencing the risk it is not quantified. The question of the indications is completely open from the scientific literature. For the question of the therapy need or therapy priority some indexes were developed, which lead to a quantification. These indices however are fundamentally criticised by recent research in their meaning and the empirical relevance.There is an impression that there exists a big gap between the practical application and the scientific

  5. On-road experiment to assess drivers' detection of roadside targets as a function of headlight system, target placement, and target reflectance.

    PubMed

    Reagan, Ian J; Brumbelow, Matt; Frischmann, Tim

    2015-03-01

    Adaptive headlights swivel with steering input to keep the beams on the roadway as drivers negotiate curves. To assess the effects of this feature on driver's visual performance, a field experiment was conducted at night on a rural, unlit, and unlined two-lane road during which 20 adult participant drivers searched a set of 60 targets. High- (n=30) and low- (n=30) reflectance targets were evenly distributed on straight road sections and on the inside or outside of curves. Participants completed three target detection trials: once with adaptive high-intensity discharge (HID) headlights, once with fixed HID headlights, and once with fixed halogen headlights. Results indicated the adaptive HID headlights helped drivers detect targets that were most difficult to see (low reflectance) at the points in curves found by other researchers to be most crucial for successful navigation (inside apex). For targets placed on straight stretches of road or on the outside of curves, the adaptive feature provided no significant improvement in target detection. However, the pattern of results indicate that HID lamps whether fixed or adaptive improved target detection somewhat, suggesting that part of the real world crash reduction measured for this adaptive system (Highway Loss Data Institute (HLDI), 2012a) may be due to the differences in the light source (HID vs. halogen). Depending on the scenario, the estimated benefits to driver response time associated with the tested adaptive (swiveling HID) headlights ranged from 200 to 380ms compared with the fixed headlight systems tested.

  6. Ecological genomics of mutualism decline in nitrogen-fixing bacteria

    PubMed Central

    Klinger, Christie R.; Lau, Jennifer A.

    2016-01-01

    Anthropogenic changes can influence mutualism evolution; however, the genomic regions underpinning mutualism that are most affected by environmental change are generally unknown, even in well-studied model mutualisms like the interaction between legumes and their nitrogen (N)-fixing rhizobia. Such genomic information can shed light on the agents and targets of selection maintaining cooperation in nature. We recently demonstrated that N-fertilization has caused an evolutionary decline in mutualistic partner quality in the rhizobia that form symbiosis with clover. Here, population genomic analyses of N-fertilized versus control rhizobium populations indicate that evolutionary differentiation at a key symbiosis gene region on the symbiotic plasmid (pSym) contributes to partner quality decline. Moreover, patterns of genetic variation at selected loci were consistent with recent positive selection within N-fertilized environments, suggesting that N-rich environments might select for less beneficial rhizobia. By studying the molecular population genomics of a natural bacterial population within a long-term ecological field experiment, we find that: (i) the N environment is indeed a potent selective force mediating mutualism evolution in this symbiosis, (ii) natural variation in rhizobium partner quality is mediated in part by key symbiosis genes on the symbiotic plasmid, and (iii) differentiation at selected genes occurred in the context of otherwise recombining genomes, resembling eukaryotic models of adaptation. PMID:26962142

  7. "No quick fixes" for environment, population balance.

    PubMed

    1992-01-01

    The 90s is a critical decade if population stabilization is to occur in a manner that is both peaceful to people and the planet. Sustainable development, population stabilization, and environmental health are not separate issues. They must all be strived for simultaneously. None will be possible without the other 2. For example, conservation measures alone will not alleviate environmental degradation. These are the basic ideas in a speech given by Werner Fornos, president of the Population Institute, to an audience of 150 including ambassadors, delegates to the UN, and UN officials. There are no quick fixes to these problems. Waiting to take action only compounds the problem. The longer we wait to address these issues, the longer, and more expensive, it is to correct them. The relationship between population growth and environmental and ecological deterioration is not always evident. That fact should in no way prevent all concerned parties from acting promptly. Population policy intervention is the least expensive method of dealing with global environmental problems. The less people there are, the less pressure there is on the Earth's resources. Fornos received a special award from Theodore W. Kheel, chair of the Earth Summit Committee. The award is a Robert Rauschenberg print, inspired by a quote from William S. Burroughs: "They did not fully understand the technique. In a short time they nearly wrecked the planet."

  8. Difficulty in dislodging in vivo fixed radiostrontium.

    PubMed

    Sonawane, V R; Jagtap, V S; Pahuja, D N; Rajan, M G R; Samuel, A M

    2004-07-01

    Many trials based on the basic phenomena of isotopic dilution, adsorption, ion exchange, chelation, etc., have been attempted for the decorporation of radiostrontium, particularly Sr, after its entry in the in vivo system. We have recently demonstrated a non-isotopic carrier effect of some common calcium salts (calcium = 9 mg mL) to reduce the whole body retention of radiostrontium, if administered within 2 h after radiostrontium exposure and furthermore once daily, in rats, supplemented with calcium fortified diet. However, 25-30% of radiostrontium (compared to 50-60% in untreated animals) was still found to be retained in the animal even after 2 wk of treatment. Trial of some simple interventional measures, which would not adversely affect the animal metabolism, like pyrophosphate and magnesium sulfate, sodium citrate, chitin (a bio-absorbent), crown ether (a metal-chelator), and ammonium chloride, was therefore attempted to dislodge this remaining radiostrontium by switching over these animals to normal diet and subjecting them to different lines of treatment with these simple interventions through diet and drinking water separately for a further 4 wk. However, this remaining portion of radiostrontium is fixed in the bone and is difficult to dislodge.

  9. Delayed reinforcement and fixed-ratio performance.

    PubMed

    Jarmolowicz, David P; Lattal, Kennon A

    2013-11-01

    Effects of delayed reinforcement on fixed-ratio (FR) maintained responding of pigeons were investigated. In Experiments 1-3, the delay of reinforcement was increased across successive sessions until pigeons paused for 300 s. Both signaled and unsignaled delays were studied across different conditions. Overall response rates and run rates (timed from the first to last response of a ratio) decreased and postreinforcement pauses increased as delays increased in each experiment. As delays increased, the likelihood of pausing during a ratio run also increased. When these measures were plotted as a function of obtained delays, signaled delays had less of an effect on the above measures than did unsignaled ones. In Experiment 2, delays had a greater effect on the above measures than did a control condition arranging equivalent interreinforcer intervals to those accompanying the delays. Experiments 3 and 4 examined the generality of the effects obtained in the first two experiments. In Experiment 3, delays imposed on FR or yoked-interval schedules had similar behavioral effects. In Experiment 4, effects similar to those found in Experiments 1-3 for 1, 10, and 20-s delays imposed on FR 50 schedules were found when the FR requirement increased across sessions. Despite the different contingencies relating response rate and reinforcement rates on interval and ratio schedules, delays of reinforcement generally affect performance on these schedules similarly.

  10. How to fix a broken clock

    PubMed Central

    Schroeder, Analyne M.; Colwell, Christopher S.

    2013-01-01

    Fortunate are those who rise out of bed to greet the morning light well rested with the energy and enthusiasm to drive a productive day. Others however, depend on hypnotics for sleep and require stimulants to awaken lethargic bodies. Sleep/wake disruption is a common occurrence in healthy individuals throughout their lifespan and is also a comorbid condition to many diseases (neurodegenerative) and psychiatric disorders (depression and bipolar). There is growing concern that chronic disruption of the sleep/wake cycle contributes to more serious conditions including diabetes (type 2), cardiovascular disease and cancer. A poorly functioning circadian system resulting in misalignments in the timing of clocks throughout the body may be at the root of the problem for many people. In this article, we discuss environmental (light therapy) and lifestyle changes (scheduled meals, exercise and sleep) as interventions to help fix a broken clock. We also discuss the challenges and potential for future development of pharmacological treatments to manipulate this key biological system. PMID:24120229

  11. Apparatus for fixed bed coal gasification

    DOEpatents

    Sadowski, Richard S.

    1992-01-01

    An apparatus for fixed-bed coal gasification is described in which coal such as caking coal is continuously pyrolyzed with clump formation inhibited, by combining the coal with a combustible gas and an oxidant, and then continually feeding the pyrolyzed coal under pressure and elevated temperature into the gasification region of a pressure vessel. The materials in the pressure vessel are allowed to react with the gasifying agents in order to allow the carbon contents of the pyrolyzed coal to be completely oxidized. The combustion of gas produced from the combination of coal pyrolysis and gasification involves combining a combustible gas coal and an oxidant in a pyrolysis chamber and heating the components to a temperature of at least 1600.degree. F. The products of coal pyrolysis are dispersed from the pyrolyzer directly into the high temperature gasification region of a pressure vessel. Steam and air needed for gasification are introduced in the pressure vessel and the materials exiting the pyrolyzer flow down through the pressure vessel by gravity with sufficient residence time to allow any carbon to form carbon monoxide. Gas produced from these reactions are then released from the pressure vessel and ash is disposed of.

  12. Fixed bed reactor for solid-phase surface derivatization of superparamagnetic nanoparticles.

    PubMed

    Steitz, Benedikt; Salaklang, Jatuporn; Finka, Andrija; O'Neil, Conlin; Hofmann, Heinrich; Petri-Fink, Alke

    2007-01-01

    The functionalization of nanoparticles is conditio sine qua non in studies of specific interaction with a biological target. Often, their biological functionality is achieved by covalent binding of bioactive molecules on a preexisting single surface coating. The yield and quality of the resulting coated and functionalized superparamagnetic iron oxide nanoparticles (SPIONs) can be significantly improved and reaction times reduced by using solid-phase synthesis strategies. In this study, a fixed bed reactor with a quadrupole repulsive arrangement of permanent magnets was assayed for SPION surface derivatization. The magnet array around the fixed bed reactor creates very high magnetic field gradients that enables the immobilization of SPIONs with a diameter as low as 9 nm. The functionalization on the surface of immobilized 25 nm 3-(aminopropyl)trimethoxysilane-coated SPIONs (APS-SPIONs) was performed using fluorescein-isothiocyanate directly, and by the SV40 large T-antigen nuclear localization signal peptide (PKKKRKVGC) conjugated to acryloylpoly(ethylene glycol)-N-hydroxysuccinimide, where the PEG reagent is conjugated first to create a functionalized nanoparticle and the peptide is added to the acryloyl group. We show that the yield of reactant grafted on the surface of the APS-coated SPIONs was higher in solid-phase within the fixed bed reactor compared to conventional liquid-phase chemistry. In summary, the functionalization of SPIONs using a magnetically fixed bed reactor was superior to the liquid-phase reaction in terms of the yield, reaction times required for derivatization, size distribution, and scalability.

  13. Accelerator target

    DOEpatents

    Schlyer, D.J.; Ferrieri, R.A.; Koehler, C.

    1999-06-29

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression. 5 figs.

  14. Accelerator target

    DOEpatents

    Schlyer, David J.; Ferrieri, Richard A.; Koehler, Conrad

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  15. Targeting circuits

    PubMed Central

    Rajasethupathy, Priyamvada; Ferenczi, Emily; Deisseroth, Karl

    2017-01-01

    Current optogenetic methodology enables precise inhibition or excitation of neural circuits, spanning timescales as needed from the acute (milliseconds) to the chronic (many days or more), for experimental modulation of network activity and animal behavior. Such broad temporal versatility, unique to optogenetic control, is particularly powerful when combined with brain activity measurements that span both acute and chronic timescales as well. This enables, for instance, the study of adaptive circuit dynamics across the intact brain, and tuning interventions to match activity patterns naturally observed during behavior in the same individual. Although the impact of this approach has been greater on basic research than on clinical translation, it is natural to ask if specific neural circuit activity patterns discovered to be involved in controlling adaptive or maladaptive behaviors could become targets for treatment of neuropsychiatric diseases. Here we consider the landscape of such ideas related to therapeutic targeting of circuit dynamics, taking note of developments not only in optical but also in ultrasonic, magnetic, and thermal methods. We note the recent emergence of first-in-kind optogenetically-guided clinical outcomes, as well as opportunities related to the integration of interventions and readouts spanning diverse circuit-physiology, molecular, and behavioral modalities. PMID:27104976

  16. A Fix by Total Solar Eclipse

    NASA Astrophysics Data System (ADS)

    Sadler, D. H.

    In anticipation of the TOTAL Solar Eclipse on 11 August 1999 (see the January/February issue of Navigation News), it seemed very appropriate to repeat this short article by one of the Institute's most respected Fellows. It was first published in Vol. VII, October 1954.A TOTAL eclipse of the Sun provides an opportunity, rare though it may be, of obtaining an instantaneous fix from the Sun alone. Eclipses vary greatly in character, in position on the Earth, in the width of the path of totality, in the duration, and also in the direction of the path. However, the shadow of the Moon cast by the Sun is always a right circular cone which, in the case of a total eclipse, intersects the Earth's surface at some point before its vertex. Owing to the motion of the Moon in its orbit round the Earth, the shadow moves at a speed of about 2000 m.p.h. from west to east (it varies considerably according to the distance of the Moon from the Earth). The intersection of this cone with the Earth's surface is an ellipse, which moves over the surface at speeds which are very high when the cone is nearly tangential (i.e. when the Sun's altitude is low) and at speeds as low as about 1000 m.p.h., when the eclipse is central over the equator at noon and the Earth's rotation has its maximum effect. The speed of the shadow is generally low enough to give a position line of considerable accuracy from the observed time of either second or third contacts, that is the beginning or ending of the total phase. An error of 1 second corresponds, in the most favourable case, to about one-third of a mile. The position line is, of course, the portion of the elliptic shadow corresponding to the observed phase and time; these can be precomputed.

  17. Auxins upregulate nif and fix genes.

    PubMed

    Bianco, Carmen; Defez, Roberto

    2010-10-01

    In a recent publication we analyzed the global effects triggered by IAA overproduction in S. meliloti RD64 under free-living conditions by comparing the gene expression pattern of wild type 1021 with that of RD64 and 1021 treated with IAA and other four chemically or functionally related molecules. Among the genes differentially expressed in RD64 and IAA-treated 1021 cells we found two genes of pho operon, phoT and phoC. Based on this finding we examined the mechanisms for mineral P solubilization in RD64 and the potential ability of this strain to improve Medicago growth under P-starved conditions. Here, we further analyze the expression profiles obtained in microarray analysis and evaluate the specificity and the extent of overlap between all treatments. Venn diagrams indicated that IAA- and 2,4-D-regulated genes were closely related. Furthermore, most differentially expressed genes from pSymA were induced in 1021 cells treated with 2,4-D, ICA, IND and Trp as compared to the untreated 1021 cells. RT-PCR analysis was employed to analyze the differential expression patterns of nitrogen fixation genes under free-living and symbiotic conditions. Under symbiotic condition, the relative expression levels of nif and fix genes were significantly induced in Mt- RD64 plants and in Mt-1021 plants treated with IAA and 2,4-D whereas they were unchanged or repressed in Mt-1021 plants treated with the other selected compounds when compared to the untreated Mt-1021 plants.

  18. Aeroelasticity Benchmark Assessment: Subsonic Fixed Wing Program

    NASA Technical Reports Server (NTRS)

    Florance, Jennifer P.; Chwalowski, Pawel; Wieseman, Carol D.

    2010-01-01

    Aeroelasticity Branch will examine other experimental efforts within the Subsonic Fixed Wing (SFW) program (such as testing of the NASA Common Research Model (CRM)) and other NASA programs and assess aeroelasticity issues and research topics.

  19. Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography

    DOE PAGES

    Mueller, C.; Marx, A.; Epp, S. W.; ...

    2015-08-18

    We present a crystallography chip enabling in situ room temperature crystallography at microfocus synchrotron beamlines and X-ray free-electron laser (X-FEL) sources. Compared to other in situ approaches, we observe extremely low background and high diffraction data quality. The chip design is robust and allows fast and efficient loading of thousands of small crystals. The ability to load a large number of protein crystals, at room temperature and with high efficiency, into prescribed positions enables high throughput automated serial crystallography with microfocus synchrotron beamlines. In addition, we demonstrate the application of this chip for femtosecond time-resolved serial crystallography at the Linacmore » Coherent Light Source (LCLS, Menlo Park, California, USA). As a result, the chip concept enables multiple images to be acquired from each crystal, allowing differential detection of changes in diffraction intensities in order to obtain high signal-to-noise and fully exploit the time resolution capabilities of XFELs.« less

  20. Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography

    PubMed Central

    Mueller, C.; Marx, A.; Epp, S. W.; Zhong, Y.; Kuo, A.; Balo, A. R.; Soman, J.; Schotte, F.; Lemke, H. T.; Owen, R. L.; Pai, E. F.; Pearson, A. R.; Olson, J. S.; Anfinrud, P. A.; Ernst, O. P.; Dwayne Miller, R. J.

    2015-01-01

    We present a crystallography chip enabling in situ room temperature crystallography at microfocus synchrotron beamlines and X-ray free-electron laser (X-FEL) sources. Compared to other in situ approaches, we observe extremely low background and high diffraction data quality. The chip design is robust and allows fast and efficient loading of thousands of small crystals. The ability to load a large number of protein crystals, at room temperature and with high efficiency, into prescribed positions enables high throughput automated serial crystallography with microfocus synchrotron beamlines. In addition, we demonstrate the application of this chip for femtosecond time-resolved serial crystallography at the Linac Coherent Light Source (LCLS, Menlo Park, California, USA). The chip concept enables multiple images to be acquired from each crystal, allowing differential detection of changes in diffraction intensities in order to obtain high signal-to-noise and fully exploit the time resolution capabilities of XFELs. PMID:26798825

  1. NICA fixed target mode: Soft jet studies in the relative 4-velocity space

    NASA Astrophysics Data System (ADS)

    Okorokov, V. A.

    2016-08-01

    Experimental results obtained by studying the properties of soft jets in the 4-velocity space at √{{s}} ˜ 2-20 GeV are presented. The changes in the mean distance from the jet axis to the jet particles, the mean kinetic energy of these particles, and the cluster dimension in response to the growth of the collision energy are consistent with the assumption that quark degrees of freedom manifest themselves in processes of pion-jet production at intermediate energies. The energy at which quark degrees of freedom begin to manifest themselves experimentally in the production of soft pion jets is estimated for the first time. The estimated value of this energy is 2.8±0.6 GeV. The suggestions are made for future investigations on NICA.

  2. A Fixed Telescopic Prosthesis Designed to Retrieve and Convert to Fixed-Removable Combination Case: A Clinical Report

    PubMed Central

    Panagiota, Spyropoulou; Polyzois, Gregory

    2015-01-01

    This clinical report describes a fixed maxillary telescopic dental prosthesis (FTDP) employing milled base metal copings and a metal superstructure veneered with composite resin, for the restoration in a periodontally compromised patient with uncontrolled diabetes. The telescopic prosthesis framework design incorporated occlusal rest seats in key positions along the arch in case of future posterior tooth loss, in order to be converted to fixed - removable combination prosthesis. The mandible was restored with a conventional fixed ceramo-metal dental prosthesis. PMID:27688397

  3. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura

    SciTech Connect

    Cirera, S.; Martin-Campos, J.M.; Segarra, C.

    1995-01-01

    The two breakpoints of a chromosomal inversion fixed since the split of Drosophila melanogaster and D. subobscura lineages have been isolated and sequenced in both species. The regions spanning the break-points initially were identified by the presence of two signals after interspecific in situ hybridization on polytene chromosomes. Interspecific comparison of the sequenced regions allowed us to delineate the location of the breakpoints. Close to one of these breakpoints a new transcription unit (bcn92) has been identified in both species. The inversion fixed between D. melanogaster and D. subobscura does not seem to have broken any transcription unit. Neither complete nor defective transposable elements were found in the regions encompassing the breakpoints. Short thymine-rich sequences (30-50 hp long) have been found bordering the breakpoint regions. Although alternating Pur-Pyr sequences were detected, these putative target sites for topoisomerase II were not differentially clustered in the breakpoints. 22 refs., 6 figs.

  4. Prostate Contouring Variation: Can It Be Fixed?

    SciTech Connect

    Khoo, Eric L.H.; Schick, Karlissa; Plank, Ashley W.; Poulsen, Michael; Wong, Winnie W.G.; Middleton, Mark; Martin, Jarad M.

    2012-04-01

    Purpose: To assess whether an education program on CT and MRI prostate anatomy would reduce inter- and intraobserver prostate contouring variation among experienced radiation oncologists. Methods and Materials: Three patient CT and MRI datasets were selected. Five radiation oncologists contoured the prostate for each patient on CT first, then MRI, and again between 2 and 4 weeks later. Three education sessions were then conducted. The same contouring process was then repeated with the same datasets and oncologists. The observer variation was assessed according to changes in the ratio of the encompassing volume to intersecting volume (volume ratio [VR]), across sets of target volumes. Results: For interobserver variation, there was a 15% reduction in mean VR with CT, from 2.74 to 2.33, and a 40% reduction in mean VR with MRI, from 2.38 to 1.41 after education. A similar trend was found for intraobserver variation, with a mean VR reduction for CT and MRI of 9% (from 1.51 to 1.38) and 16% (from 1.37 to 1.15), respectively. Conclusion: A well-structured education program has reduced both inter- and intraobserver prostate contouring variations. The impact was greater on MRI than on CT. With the ongoing incorporation of new technologies into routine practice, education programs for target contouring should be incorporated as part of the continuing medical education of radiation oncologists.

  5. Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

    PubMed Central

    Kohut, Lauryn K.; Darwiche, Sophie S.; Brumfield, John M.; Frank, Alicia M.; Billiar, Timothy R.

    2011-01-01

    It is common knowledge that severe blood loss and traumatic injury can lead to a cascade of detrimental signaling events often resulting in mortality. 1, 2, 3, 4, 5 These signaling events can also lead to sepsis and/or multiple organ dysfunction (MOD). 6, 7, 8, 9 It is critical then to investigate the causes of suppressed immune function and detrimental signaling cascades in order to develop more effective ways to help patients who suffer from traumatic injuries. 10 This fixed pressure Hemorrhagic Shock (HS) procedure, although technically challenging, is an excellent resource for investigation of these pathophysiologic conditions. 11, 12, 13 Advances in the assessment of biological systems, i.e. Systems Biology have enabled the scientific community to further understand complex physiologic networks and cellular communication patterns. 14 Hemorrhagic Shock has proven to be a vital tool for unveiling these cellular communication patterns as they relate to immune function. 15, 16, 17, 18 This procedure can be mastered! This procedure can also be used as either a fixed volume or fixed pressure approach. We adapted this technique in the murine model to enhance research in innate and adaptive immune function. 19, 20, 21 Due to their small size HS in mice presents unique challenges. However due to the many available mouse strains, this species represents an unparalleled resource for the study of the biologic responses. The HS model is an important model for studying cellular communication patterns and the responses of systems such as hormonal and inflammatory mediator systems, and danger signals, i.e. DAMP and PAMP upregulation as it elicits distinct responses that differ from other forms of shock. 22, 23, 24, 25 The development of transgenic murine strains and the induction of biologic agents to inhibit specific signaling have presented valuable opportunities to further elucidate our understanding of the up and down regulation of signal transduction after severe blood

  6. 46 CFR 108.631 - Fixed fire extinguishing system controls.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Fixed fire extinguishing system controls. 108.631 Section 108.631 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE... system controls. (a) Each cabinet or space that contains a valve, control, or manifold of a fixed...

  7. 12 CFR 701.36 - FCU ownership of fixed assets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... facility, or real estate where the credit union transacts or will transact business. (7) Senior management... Fixed Assets. (1) No Federal credit union with $1,000,000 or more in assets may invest in any fixed... real property not intended for use in the conduct of credit union business. The credit union must...

  8. 12 CFR 701.36 - FCU ownership of fixed assets.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facility, or real estate where the credit union transacts or will transact business. (7) Senior management... Fixed Assets. (1) No Federal credit union with $1,000,000 or more in assets may invest in any fixed... real property not intended for use in the conduct of credit union business. The credit union must...

  9. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Stations at temporary fixed locations. 101.815 Section 101.815 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at...

  10. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Coordination with fixed microwave service. 15.307 Section 15.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service....

  11. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Stations at temporary fixed locations. 101.815 Section 101.815 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at...

  12. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Stations at temporary fixed locations. 101.815 Section 101.815 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at...

  13. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Coordination with fixed microwave service. 15.307 Section 15.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service....

  14. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Coordination with fixed microwave service. 15.307 Section 15.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service....

  15. 46 CFR 76.05-20 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Fixed fire extinguishing systems. 76.05-20 Section 76.05-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 76.05-20 Fixed...

  16. 46 CFR 95.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Fixed fire extinguishing systems. 95.05-10 Section 95.05... FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-10 Fixed fire extinguishing systems. (a) Approved fire extinguishing systems may be used or required...

  17. 46 CFR 95.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Fixed fire extinguishing systems. 95.05-10 Section 95.05... FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-10 Fixed fire extinguishing systems. (a) Approved fire extinguishing systems may be used or required...

  18. 46 CFR 193.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fixed fire extinguishing systems. 193.05-10 Section 193... VESSELS FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 193.05-10 Fixed fire extinguishing systems. (a) Approved fire extinguishing systems must be installed in all...

  19. 29 CFR 1910.24 - Fixed industrial stairs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Fixed industrial stairs. 1910.24 Section 1910.24 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.24 Fixed industrial stairs....

  20. 48 CFR 846.302 - Fixed-price supply contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fixed-price supply contracts. 846.302 Section 846.302 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.302 Fixed-price supply contracts....

  1. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... floating roof. (b) The tank shall be equipped with a fixed roof designed to meet the following specifications: (1) The fixed roof and its closure devices shall be designed to form a continuous barrier over... closure device designed to operate such that when the closure device is secured in the closed...

  2. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... floating roof. (b) The tank shall be equipped with a fixed roof designed to meet the following specifications: (1) The fixed roof and its closure devices shall be designed to form a continuous barrier over... closure device designed to operate such that when the closure device is secured in the closed...

  3. 47 CFR 22.737 - Temporary fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., upon proper application therefor, authorize the construction and operation of temporary fixed stations... 47 Telecommunication 2 2010-10-01 2010-10-01 false Temporary fixed stations. 22.737 Section 22.737 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES...

  4. 47 CFR 22.737 - Temporary fixed stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., upon proper application therefor, authorize the construction and operation of temporary fixed stations... 47 Telecommunication 2 2011-10-01 2011-10-01 false Temporary fixed stations. 22.737 Section 22.737 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES...

  5. 46 CFR 95.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... in special cases: (1) A fixed foam system may be used in cargo tanks. (2) A water sprinkling system.... Alternately, the Commandant may permit the installation of an approved water sprinkler system or other... is contracted for on or after November 19, 1952, a fixed carbon dioxide, foam, or water spray...

  6. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Electronic position fixing devices. 184.410 Section 184.410 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic...

  7. 40 CFR 63.1042 - Standards-Separator fixed roof.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) National Emission Standards for Oil-Water Separators and Organic-Water Separators § 63.1042 Standards... controlling air emissions from an oil-water separator or organic-water separator using a fixed roof. (b) The... interface of the roof edge and the separator wall. (3) Each opening in the fixed roof shall be equipped...

  8. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Electronic position fixing devices. 184.410 Section 184.410 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic...

  9. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Stations at temporary fixed locations. 101.815 Section 101.815 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at...

  10. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Stations at temporary fixed locations. 101.815 Section 101.815 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at...

  11. 46 CFR 169.565 - Fixed carbon dioxide system.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fixed carbon dioxide system. 169.565 Section 169.565... Lifesaving and Firefighting Equipment Firefighting Equipment § 169.565 Fixed carbon dioxide system. (a) The number of pounds of carbon dioxide required for each space protected must be equal to the gross volume...

  12. 46 CFR 169.565 - Fixed carbon dioxide system.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fixed carbon dioxide system. 169.565 Section 169.565... Lifesaving and Firefighting Equipment Firefighting Equipment § 169.565 Fixed carbon dioxide system. (a) The number of pounds of carbon dioxide required for each space protected must be equal to the gross volume...

  13. Doxycycline induced generalized bullous fixed drug eruption - A case report.

    PubMed

    Nitya, Selvaraj; Deepa, Kameswari; Mangaiarkkarasi, Adhimoolam; Karthikeyan, Kaliaperumal

    2013-12-01

    Adverse drug reactions are a major hazard of modern medicine. Fixed drug eruption, which is a cutaneous adverse drug reaction, is commonly seen with antimicrobials and analgesics. Here we report 37-year-old female with bullous fixed drug eruptions due to doxycycline administration.

  14. Generalized bullous fixed drug eruption treated with cyclosporine.

    PubMed

    Malviya, Neeta; Cyrus, Nika; Vandergriff, Travis; Mauskar, Melissa

    2017-02-15

    Fixed drug eruptions (FDE) comprise 10 percent of alladverse cutaneous drug reactions and generalizedbullous fixed drug eruptions (GBFDE) are a raresubset of FDEs. We present a patient with severeGBFDE caused by ibuprofen successfully treated withcyclosporine. Further work is needed to determine ifcyclosporine can be an effective therapy for GBFDE.

  15. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  16. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  17. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Hand-operated fixed derails. 218.109 Section 218.109 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  18. 48 CFR 846.302 - Fixed-price supply contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Fixed-price supply contracts. 846.302 Section 846.302 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.302 Fixed-price supply contracts....

  19. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed to... an approved carbon dioxide, Halon 1301, halogenated, or clean agent type and installed to the... open to the atmosphere as to make the use of a fixed system ineffective; (2) Any paint or oil room,...

  20. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed to... an approved carbon dioxide, Halon 1301, halogenated, or clean agent type and installed to the... open to the atmosphere as to make the use of a fixed system ineffective; (2) Any paint or oil room,...

  1. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed to... an approved carbon dioxide, Halon 1301, halogenated, or clean agent type and installed to the... open to the atmosphere as to make the use of a fixed system ineffective; (2) Any paint or oil room,...

  2. 12 CFR 619.9180 - Fixed interest spread.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Fixed interest spread. 619.9180 Section 619.9180 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9180 Fixed interest spread. A percentage to be added to the cost of money to the bank or association as the means...

  3. 12 CFR 619.9170 - Fixed interest rate.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Fixed interest rate. 619.9170 Section 619.9170 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM DEFINITIONS § 619.9170 Fixed interest rate. The rate of interest specified in the note or loan document which will prevail as the...

  4. 29 CFR 1910.24 - Fixed industrial stairs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the angle of which changes with the rise and fall of the base support. (b) Where fixed stairs are... rise. Fixed stairs shall be installed at angles to the horizontal of between 30° and 50°. Any uniform combination of rise/tread dimensions may be used that will result in a stairway at an angle to the...

  5. Photogrammetric Measurements in Fixed Wing Uav Imagery

    NASA Astrophysics Data System (ADS)

    Gülch, E.

    2012-07-01

    Several flights have been undertaken with PAMS (Photogrammetric Aerial Mapping System) by Germap, Germany, which is briefly introduced. This system is based on the SmartPlane fixed-wing UAV and a CANON IXUS camera system. The plane is equipped with GPS and has an infrared sensor system to estimate attitude values. A software has been developed to link the PAMS output to a standard photogrammetric processing chain built on Trimble INPHO. The linking of the image files and image IDs and the handling of different cases with partly corrupted output have to be solved to generate an INPHO project file. Based on this project file the software packages MATCH-AT, MATCH-T DSM, OrthoMaster and OrthoVista for digital aerial triangulation, DTM/DSM generation and finally digital orthomosaik generation are applied. The focus has been on investigations on how to adapt the "usual" parameters for the digital aerial triangulation and other software to the UAV flight conditions, which are showing high overlaps, large kappa angles and a certain image blur in case of turbulences. It was found, that the selected parameter setup shows a quite stable behaviour and can be applied to other flights. A comparison is made to results from other open source multi-ray matching software to handle the issue of the described flight conditions. Flights over the same area at different times have been compared to each other. The major objective was here to see, on how far differences occur relative to each other, without having access to ground control data, which would have a potential for applications with low requirements on the absolute accuracy. The results show, that there are influences of weather and illumination visible. The "unusual" flight pattern, which shows big time differences for neighbouring strips has an influence on the AT and DTM/DSM generation. The results obtained so far do indicate problems in the stability of the camera calibration. This clearly requests a usage of GCPs for all

  6. Polarized nuclear target based on parahydrogen induced polarization

    SciTech Connect

    D. Budker, M.P. Ledbetter, S. Appelt, L.S. Bouchard, B. Wojtsekhowski

    2012-12-01

    We discuss a novel concept of a polarized nuclear target for accelerator fixed-target scattering experiments, which is based on parahydrogen induced polarization (PHIP). One may be able to reach a 33% free-proton polarization in the ethane molecule. The potential advantages of such a target include operation at zero magnetic field, fast ({approx}100 HZ) polarization oscillation (akin to polarization reversal), and operation with large intensity of an electron beam.

  7. 48 CFR 1852.216-83 - Fixed price incentive.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Price Incentive (OCT 1996) The target cost of this contract is $___. The Target profit of this contract is $___. The target price (target cost plus target profit) of this contract is $___. The cost sharing for target cost underruns is: Government ___percent; Contractor ___percent. The cost sharing...

  8. Optical characterization of solar furnace system using fixed geometry nonimaging focusing heliostat and secondary parabolic concentrator

    NASA Astrophysics Data System (ADS)

    Chong, Kok-Keong; Lim, Chuan-Yang; Keh, Wee-Liang; Fan, Jian-Hau; Rahman, Faidz Abdul

    2011-10-01

    A novel solar furnace system has been proposed to be consisted of a Nonimaging Focusing Heliostat and a smaller parabolic concentrator. In this configuration, the primary heliostat consists of 11×11 array of concave mirrors with a total reflective area of 121 m2 while the secondary parabolic concentrator has a focal length of 30 cm. To simplify the design and reduce the cost, fixed geometry of the primary heliostat is adopted to omit the requirement of continuous astigmatic correction throughout a year. The overall performance of the novel solar furnace configuration can be optimized if the heliostat's spinning-axis is fixed in the orientation dependent on the latitude angle so that the annual variation of incidence angle is the least, which ranges from 33° to 57°. Case study of the novel solar furnace system has been performed with the use of ray-tracing method to simulate solar flux distribution profile for two different target distances, i.e. 50 m and 100 m. The simulated results have revealed that the maximum solar concentration ratio ranges from 20,530 suns to 26,074 suns for the target distance of 50 m, and ranges from 40,366 suns to 43,297 suns for the target distance of 100 m.

  9. Auctionable fixed transmission rights for congestion management

    NASA Astrophysics Data System (ADS)

    Alomoush, Muwaffaq Irsheid

    the transaction by the ISO, take a decision to expand the existing system, or retain the original structure of the system. Also, the thesis investigates the impact of wheeling transactions on congestion management, where we present a generalized mathematical model for the Fixed Transmission Right (FTR) auction. The auction guarantees FTR availability to all participants on a non-discriminatory basis, in which system users are permitted to buy, sell and trade FTRs through an auction. When FTRs are utilized with LMPs, they increase the efficient use of the transmission system and let a transmission customer gain advantageous features such as acquiring a mechanism to offset the extra cost due to congestion charges, providing financial and operational certainty and making system users pay for the actual use of the congested paths. The thesis also highlighted FTR trading in secondary markets to self-arrange access across different paths, create long-term transmission rights and provide more commercial certainty.

  10. Fixed-time stability of dynamical systems and fixed-time synchronization of coupled discontinuous neural networks.

    PubMed

    Hu, Cheng; Yu, Juan; Chen, Zhanheng; Jiang, Haijun; Huang, Tingwen

    2017-05-01

    In this paper, the fixed-time stability of dynamical systems and the fixed-time synchronization of coupled discontinuous neural networks are investigated under the framework of Filippov solution. Firstly, by means of reduction to absurdity, a theorem of fixed-time stability is established and a high-precision estimation of the settling-time is given. It is shown by theoretic proof that the estimation bound of the settling time given in this paper is less conservative and more accurate compared with the classical results. Besides, as an important application, the fixed-time synchronization of coupled neural networks with discontinuous activation functions is proposed. By designing a discontinuous control law and using the theory of differential inclusions, some new criteria are derived to ensure the fixed-time synchronization of the addressed coupled networks. Finally, two numerical examples are provided to show the effectiveness and validity of the theoretical results.

  11. Look before you seek: Preview adds a fixed benefit to all searches

    PubMed Central

    Sunder, Sricharan; Arun, S. P.

    2016-01-01

    Knowing in advance what to look for speeds up search, but how this knowledge guides search is poorly understood. The little available evidence suggests that previewing the target produces larger reductions in search times for harder searches. To investigate this issue further, we performed seven experiments in which subjects searched for an oddball target after previewing the target, distracter, or an unrelated square. Consistent with previous studies, harder searches showed bigger reductions in search time for an informative preview. However, the same data replotted using the reciprocal of search time showed a remarkably different result: The informative preview showed a fixed additive increase in reciprocal search time across all searches regardless of difficulty. This is a nontrivial outcome because it cannot be explained using a simple relationship between search times in the informative and uninformative preview conditions. We interpret our findings by proposing that the reciprocal of search time reflects the strength of an underlying accumulating signal related to the distinctiveness or salience of the target over the distracters and that preview additively increases this signal for all searches. This in turn implies that the top-down signals related to target preview and bottom-up signals related to target-distracter salience sum linearly. PMID:27919099

  12. Safe switching from a pdFIX (Immunine®) to a rFIX (Bax326).

    PubMed

    Solano Trujillo, M H; Stasyshyn, O; Rusen, L; Serban, M; Lamas, J L; Perina, F G; Urasinski, T; Oh, M; Knowlton, W B; Valenta-Singer, B; Pavlova, B G; Abbuehl, B

    2014-09-01

    The ability to switch between coagulation factors safely is of common interest to haemophilia patients and treating physicians. This is the first formal prospective comparative evaluation of safety, efficacy and incremental recovery of a plasma-derived FIX (pdFIX) and a recombinant FIX (rFIX) in the same haemophilia B patients following a switch from pdFIX Immunine® to a recently developed rFIX Bax326 product. Patients (aged <65 years) who completed a pretreatment study which prospectively documented the exposure to Immunine® and monitored FIX inhibitors while receiving prophylactic treatment were transitioned into pivotal (patients aged 12-65 years) and paediatric (patients aged <12 years) clinical studies investigating prophylaxis and treatment of bleeding episodes with Bax326. None of the 44 patients developed inhibitory or specific binding anti-FIX antibodies during the course of the studies. A total of 38 unrelated adverse events (AEs) were occurred in 20/44 (45.5%) subjects during the Immunine® study. Following a switch to Bax326, 51 AEs were reported in 25/44 (56.8%) subjects. The incidence of AEs related to Bax326 treatment (two episodes of dysgeusia in one patient) was low (2.3%); there were no serious adverse reactions. The comparison between Immunine® and Bax326 demonstrated analogous haemostatic characteristics and annualized bleeding rates. Overall, there is direct evidence indicating a safe and clinically effective transition from a pdFIX (Immunine®) to a newly developed rFIX (Bax326(1) ) for prophylaxis and treatment of bleeding in previously treated patients of all age cohorts with severe or moderately severe haemophilia B.

  13. Students' Target

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Context image for PIA03648 Ascraeus Mons

    After examining numerous THEMIS images and using the JMars targeting software, eighth grade students from Charleston Middle School in Charleston, IL, selected the location of -8.37N and 276.66E for capture by the THEMIS visible camera during Mars Odyssey's sixth orbit of Mars on Nov. 22, 2005. The students are investigating relationships between channels, craters, and basins on Mars. The Charleston Middle School students participated in the Mars Student Imaging Project (MSIP) and submitted a proposal to use the THEMIS visible camera.

    Image information: VIS instrument. Latitude 8.8S, Longitude 279.6E. 17 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  14. A new compact fixed-point blackbody furnace

    SciTech Connect

    Hiraka, K.; Oikawa, H.; Shimizu, T.; Kadoya, S.; Kobayashi, T.; Yamada, Y.; Ishii, J.

    2013-09-11

    More and more NMIs are realizing their primary scale themselves with fixed-point blackbodies as their reference standard. However, commercially available fixed-point blackbody furnaces of sufficient quality are not always easy to obtain. CHINO Corp. and NMIJ, AIST jointly developed a new compact fixed-point blackbody furnace. The new furnace has such features as 1) improved temperature uniformity when compared to previous products, enabling better plateau quality, 2) adoption of the hybrid fixed-point cell structure with internal insulation to improve robustness and thereby to extend lifetime, 3) easily ejectable and replaceable heater unit and fixed-point cell design, leading to reduced maintenance cost, 4) interchangeability among multiple fixed points from In to Cu points. The replaceable cell feature facilitates long term maintenance of the scale through management of a group of fixed-point cells of the same type. The compact furnace is easily transportable and therefore can also function as a traveling standard for disseminating the radiation temperature scale, and for maintaining the scale at the secondary level and industrial calibration laboratories. It is expected that the furnace will play a key role of the traveling standard in the anticipated APMP supplementary comparison of the radiation thermometry scale.

  15. N2-fixing red alder indirectly accelerates ecosystem nitrogen cycling

    USGS Publications Warehouse

    Perakis, Steven S.; Matkins, Joselin J.; Hibbs, David E.

    2012-01-01

    Symbiotic N2-fixing tree species can accelerate ecosystem N dynamics through decomposition via direct pathways by producing readily decomposed leaf litter and increasing N supply to decomposers, as well as via indirect pathways by increasing tissue and detrital N in non-fixing vegetation. To evaluate the relative importance of these pathways, we compared three-year decomposition and N dynamics of N2-fixing red alder leaf litter (2.34 %N) to both low-N (0.68 %N) and high-N (1.21 %N) litter of non-fixing Douglas-fir, and decomposed each litter source in four forests dominated by either red alder or Douglas-fir. We also used experimental N fertilization of decomposition plots to assess elevated N availability as a potential mechanism of N2-fixer effects on litter mass loss and N dynamics. Direct effects of N2-fixing red alder on decomposition occurred primarily as faster N release from red alder than Douglas-fir litter, but direct increases in N supply to decomposers via fertilization did not stimulate decomposition of any litter. Fixed N indirectly influenced detrital dynamics by increasing Douglas-fir tissue and litter N concentrations, which accelerated litter N release without accelerating mass loss. By increasing soil N, tissue N, and the rate of N release from litter of non-fixers, we conclude that N2-fixing vegetation can indirectly foster plant-soil feedbacks that contribute to the persistence of elevated N availability in terrestrial ecosystems.

  16. Meshless method for solving fixed boundary problem of plasma equilibrium

    NASA Astrophysics Data System (ADS)

    Imazawa, Ryota; Kawano, Yasunori; Itami, Kiyoshi

    2015-07-01

    This study solves the Grad-Shafranov equation with a fixed plasma boundary by utilizing a meshless method for the first time. Previous studies have utilized a finite element method (FEM) to solve an equilibrium inside the fixed separatrix. In order to avoid difficulties of FEM (such as mesh problem, difficulty of coding, expensive calculation cost), this study focuses on the meshless methods, especially RBF-MFS and KANSA's method to solve the fixed boundary problem. The results showed that CPU time of the meshless methods was ten to one hundred times shorter than that of FEM to obtain the same accuracy.

  17. Linear and angular retroreflecting interferometric alignment target

    DOEpatents

    Maxey, L. Curtis

    2001-01-01

    The present invention provides a method and apparatus for measuring both the linear displacement and angular displacement of an object using a linear interferometer system and an optical target comprising a lens, a reflective surface and a retroreflector. The lens, reflecting surface and retroreflector are specifically aligned and fixed in optical connection with one another, creating a single optical target which moves as a unit that provides multi-axis displacement information for the object with which it is associated. This displacement information is useful in many applications including machine tool control systems and laser tracker systems, among others.

  18. Neurochemical changes correlated with behavior maintained under fixed-interval and fixed-ratio schedules of reinforcement.

    PubMed Central

    Barrett, J E; Hoffmann, S M

    1991-01-01

    Key pecking of 4 pigeons was maintained under a multiple 3-min fixed-interval, 30-response fixed-ratio schedule of food presentation. Only one schedule was in effect during an experimental session, and each was correlated with a different keylight stimulus and location (left vs. right). The different schedule components alternated across days or weeks. Cerebrospinal fluid was collected from chronically implanted intracerebroventricular cannulae following sessions with the different schedules, as well as following sessions in which reinforcement was withheld (extinction), when response-independent food was delivered, and when the experimental chamber was dark and there were no scheduled events. Metabolites of the neurotransmitters serotonin, norepinephrine, and dopamine were assayed in cerebrospinal fluid using high-performance liquid chromatography with electrochemical detection. Compared to the fixed-ratio condition, responding maintained under the fixed-interval schedule resulted in consistently higher levels of the serotonin metabolite 5-hydroxyindoleacetic acid and of the dopamine metabolite homovanillic acid in all pigeons. Levels of 3-methoxy-4-hydroxyphenylethylene glycol, a metabolite of norepinephrine, and dihydroxyphenylacetic acid, another dopamine metabolite, were also higher in 3 of the 4 pigeons following exposure to the fixed-interval schedules when compared to levels of these metabolites after exposure to the fixed-ratio schedule. Extinction of fixed-ratio responding resulted in large increases in 5-hydroxyindoleacetic acid compared to levels of this metabolite under the fixed-ratio schedule, whereas this serotonin metabolite decreased during extinction of responding under the fixed-interval schedule. Control procedures suggested that the neurochemical changes were not related to the rate of responding but were a function of the specific experimental conditions. Distinctive neurochemical changes that accompany schedule-controlled responding show the

  19. 16. PIER CAP DETAIL, SHOWING EXPANSION AND FIXED BEARING SHOES, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. PIER CAP DETAIL, SHOWING EXPANSION AND FIXED BEARING SHOES, BOTTOM CHORD / END POST CONNECTION AND CANTILEVERED SIDEWALK. VIEW TO WEST. - Holbrook Bridge, Spanning Little Colorado River at AZ 77, Holbrook, Navajo County, AZ

  20. Optimum quantum states for interferometers with fixed and moving mirrors

    SciTech Connect

    Luis, Alfredo

    2004-04-01

    We address a systematic approach to the study of the optimum states reaching maximum resolution for interferometers with moving mirrors. We find a correspondence between the optimum states for interferometers with fixed and moving mirrors.

  1. 9. DETAIL OF FIXED SUPPORT (A RECENT ADDITION THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. DETAIL OF FIXED SUPPORT (A RECENT ADDITION -- THE BRIDGE IS NO LONGER MOVEABLE) AND LOWER CHORD OF THROUGH TRUSS, LOOKING SOUTH - Romeo Road, Sanitary & Ship Canal Bridge, Spanning Sanitary & Ship Canal, Romeoville, Will County, IL

  2. Simple circuit produces high-speed, fixed duration pulses

    NASA Technical Reports Server (NTRS)

    Garrahan, N. M.

    1965-01-01

    Circuit generates an output pulse of fixed width from a variable width input pulse. The circuit consists of a tunnel diode in parallel with an inductance driven by a constant current generator. It is used for pulsed communication equipment design.

  3. FIXED END OF MIDDLE SPAN. WESTERN SIDE SHOWING WELDING OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FIXED END OF MIDDLE SPAN. WESTERN SIDE SHOWING WELDING OF TOP PLATE ADDED TO STRENGTHEN THE BRIDGE. - Spile Bridge Road Bridge, Spanning Black Lake Outlie at Spile Bridge Road, Oswegatchie, St. Lawrence County, NY

  4. Simple solutions for hyperbolic and related position fixes

    NASA Astrophysics Data System (ADS)

    Fang, Bertrand T.

    1990-09-01

    Navigation fixed from range differences to three stations and an additional piece of information are investigated. It is shown that if the additional information is the navigator altitude, or the range difference to a fourth station, the computation of the navigation fix is reduced to finding the roots of a quadratic. If the additional information is the range to another station, or that the navigator is on the earth ellipsoid, the fix can be obtained by solving a quartic. By emphasizing the underlying geometric interpretations, these fixes and their simple solutions are made clear. The derivations also show that the same solution algorithms are applicable if the basic navigation measurements are range sums instead of range differences.

  5. 13. VIEW OF PIER 2, SHOWING FIXED SHOES, THE SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. VIEW OF PIER 2, SHOWING FIXED SHOES, THE SOUTH GIRDER (PANELS 3 & 2), AND CANTILEVER BRACKETS & HANDRAIL, LOOKING NORTHWEST Harms - Benton Street Bridge, Spanning Iowa River at Benton Street, Iowa City, Johnson County, IA

  6. 52. Fixed Span, Top Chord at Panel Point 6; diagonal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    52. Fixed Span, Top Chord at Panel Point 6; diagonal member goes to intermediate connection 7 & then to bottom chord at 8; looking ESE. - Pacific Shortline Bridge, U.S. Route 20,spanning Missouri River, Sioux City, Woodbury County, IA

  7. 48. Fixed Span, Detail of Pinned Connection between End Post ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    48. Fixed Span, Detail of Pinned Connection between End Post & First Segment of Top Chord (Vertical Tension Member goes to 2L); looking E. - Pacific Shortline Bridge, U.S. Route 20,spanning Missouri River, Sioux City, Woodbury County, IA

  8. Detail view of fixed end of northernmost truss span. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail view of fixed end of northernmost truss span. - Pittsburgh, Fort Wayne & Chicago Railway, Beaver River Bridge, Spanning Beaver River along line of Second Avenue, New Brighton, Beaver County, PA

  9. Interior view of fixed end of northernmost truss span, looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior view of fixed end of northernmost truss span, looking due south. - Pittsburgh, Fort Wayne & Chicago Railway, Beaver River Bridge, Spanning Beaver River along line of Second Avenue, New Brighton, Beaver County, PA

  10. An Alternative to the Fixed Step Salary Schedule

    ERIC Educational Resources Information Center

    Bruno, James E.

    1970-01-01

    The focus of this study is the development of an effective alternative to fixed step salary approaches to salary evaluation in school districts. A prototype model was derived which considered nine factors in salary evaluation. (Author/MF)

  11. Fixed-node diffusion Monte Carlo method for lithium systems

    NASA Astrophysics Data System (ADS)

    Rasch, K. M.; Mitas, L.

    2015-07-01

    We study lithium systems over a range of a number of atoms, specifically atomic anion, dimer, metallic cluster, and body-centered-cubic crystal, using the fixed-node diffusion Monte Carlo method. The focus is on analysis of the fixed-node errors of each system, and for that purpose we test several orbital sets in order to provide the most accurate nodal hypersurfaces. The calculations include both core and valence electrons in order to avoid any possible impact by pseudopotentials. To quantify the fixed-node errors, we compare our results to other highly accurate calculations, and wherever available, to experimental observations. The results for these Li systems show that the fixed-node diffusion Monte Carlo method achieves accurate total energies, recovers 96 -99 % of the correlation energy, and estimates binding energies with errors bounded by 0.1 eV /at .

  12. 41. Detail showing meeting of two fixed land span segments, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. Detail showing meeting of two fixed land span segments, bridge land span at left, viaduct at right. VIEW NORTH - Broadway Bridge, Spanning Foundry Street, MBTA Yard, Fort Point Channel, & Lehigh Street, Boston, Suffolk County, MA

  13. Careful Planning Key to Accurate Fixed Reports Assets.

    ERIC Educational Resources Information Center

    MaRous, Arnold M.

    1986-01-01

    Only with careful planning can school business managers develop fixed asset information and good recordkeeping. Use of a simple inventory system and discussion with school districts already utilizing this system will assist planning. (CJH)

  14. 15. PLAN OF OFFICE, DETAILS, FIXED WINDOW GUARDS, SHEET NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. PLAN OF OFFICE, DETAILS, FIXED WINDOW GUARDS, SHEET NO. 1-10-39/10 OF 12. - Oakland Army Base, Warehouse Type, Tobruk Street, between Warehouse Road & Fifteenth Street, Oakland, Alameda County, CA

  15. 16. DETAIL OF SOUTH ABUTMENT, SHOWING GIRDER, CYLINDRICAL FIXED BEARING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. DETAIL OF SOUTH ABUTMENT, SHOWING GIRDER, CYLINDRICAL FIXED BEARING SHOE AND LATERAL BRACING. VIEW TO SOUTHWEST. - Rio Puerco Bridge, Mainline Road, spanning Rio Puerco, Holbrook, Navajo County, AZ

  16. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and portable ladders. (a) There shall be at least one safe and accessible ladder for each gang working... of gangs present. (b) When any fixed ladder is visibly unsafe (or known to be unsafe), the...

  17. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and portable ladders. (a) There shall be at least one safe and accessible ladder for each gang working... of gangs present. (b) When any fixed ladder is visibly unsafe (or known to be unsafe), the...

  18. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and portable ladders. (a) There shall be at least one safe and accessible ladder for each gang working... of gangs present. (b) When any fixed ladder is visibly unsafe (or known to be unsafe), the...

  19. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and portable ladders. (a) There shall be at least one safe and accessible ladder for each gang working... of gangs present. (b) When any fixed ladder is visibly unsafe (or known to be unsafe), the...

  20. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and portable ladders. (a) There shall be at least one safe and accessible ladder for each gang working... of gangs present. (b) When any fixed ladder is visibly unsafe (or known to be unsafe), the...

  1. Fixed pitch rotor performance of large horizontal axis wind turbines

    NASA Technical Reports Server (NTRS)

    Viterna, L. A.; Corrigan, R. D.

    1982-01-01

    Experimental fixed pitch wind turbine performance data is presented for both the DOE/NASA Mod-0 and the Danish Gedser wind turbines. Furthermore, a method for calculating the output power from large fixed pitch wind turbines is presented. Modifications to classical blade element momentum theory are given that improve correlation with measured data. Improvement is particularly evident in high winds (low tip speed ratios) where aerodynamic stall occurs as the blade experiences high angles of attack.

  2. [Comparative estimation of morphofunction characteristics alive and fixed erythrocytes].

    PubMed

    Skorkina, M Iu; Fedorova, M Z; Cherniavskikh, S D; Zabiniakov, N A; Sladkova, E A

    2011-01-01

    The method of power spectroscopy carries out the quantitative analysis of elastic properties of alive cells. It has been established that the highest indicators of elasticity nuclear (amphibious) and denuclearized (mammals) alive erythrocytes are registered in epi- and perinuclear space. When fixing with methanol and drying of cells the greatest values of the elastic modulus are displaced to the periphery of the cells. The revealed inversion of elasticity properties of erythrocytes must be considered when assessing the morphofunction characteristics of the fixed cells.

  3. The Technological Fix: Weapons and the Cost of War.

    DTIC Science & Technology

    1995-06-06

    millennium B.C. was replaced by the horse. Second, a light chariot evolved boasting standard features that transcended regional variations−two spoked wheels , a...central, curved draft pole harnessing two to four horses, a fixed axle set beneath the rear of the rider’s box, and a railing to support the driver...fix by an enterprising American painter, inventor , and opportunist named Robert Fulton.36 Penetrating the reigning paradigm of naval warfare, Fulton

  4. Attacks on fixed-apparatus quantum-key-distribution schemes

    NASA Astrophysics Data System (ADS)

    Boyer, Michel; Gelles, Ran; Mor, Tal

    2014-07-01

    We consider quantum-key-distribution implementations in which the receiver's apparatus is fixed and does not depend on his choice of basis at each qubit transmission. We show that, although theoretical quantum key distribution is proven secure, such implementations are totally insecure against a strong eavesdropper that has one-time (single) access to the receiver's equipment. The attack we present here, the "fixed-apparatus attack," causes a potential risk to the usefulness of several recent implementations.

  5. Fundamental theorem on gauge fixing at the action level

    NASA Astrophysics Data System (ADS)

    Motohashi, Hayato; Suyama, Teruaki; Takahashi, Kazufumi

    2016-12-01

    Regardless of the long history of gauge theories, it is not well recognized under which condition gauge fixing at the action level is legitimate. We address this issue from the Lagrangian point of view, and prove the following theorem on the relation between gauge fixing and Euler-Lagrange equations: In any gauge theory, if a gauge fixing is complete, i.e., the gauge functions are determined uniquely by the gauge conditions, the Euler-Lagrange equations derived from the gauge-fixed action are equivalent to those derived from the original action supplemented with the gauge conditions. Otherwise, it is not appropriate to impose the gauge conditions before deriving Euler-Lagrange equations as it may in general lead to inconsistent results. The criterion to check whether a gauge fixing is complete or not is further investigated. We also provide applications of the theorem to scalar-tensor theories and make comments on recent relevant papers on theories of modified gravity, in which there are confusions on gauge fixing and counting physical degrees of freedom.

  6. Contamination effects on fixed-bias Langmuir probes

    SciTech Connect

    Steigies, C. T.; Barjatya, A.

    2012-11-15

    Langmuir probes are standard instruments for plasma density measurements on many sounding rockets. These probes can be operated in swept-bias as well as in fixed-bias modes. In swept-bias Langmuir probes, contamination effects are frequently visible as a hysteresis between consecutive up and down voltage ramps. This hysteresis, if not corrected, leads to poorly determined plasma densities and temperatures. With a properly chosen sweep function, the contamination parameters can be determined from the measurements and correct plasma parameters can then be determined. In this paper, we study the contamination effects on fixed-bias Langmuir probes, where no hysteresis type effect is seen in the data. Even though the contamination is not evident from the measurements, it does affect the plasma density fluctuation spectrum as measured by the fixed-bias Langmuir probe. We model the contamination as a simple resistor-capacitor circuit between the probe surface and the plasma. We find that measurements of small scale plasma fluctuations (meter to sub-meter scale) along a rocket trajectory are not affected, but the measured amplitude of large scale plasma density variation (tens of meters or larger) is attenuated. From the model calculations, we determine amplitude and cross-over frequency of the contamination effect on fixed-bias probes for different contamination parameters. The model results also show that a fixed bias probe operating in the ion-saturation region is affected less by contamination as compared to a fixed bias probe operating in the electron saturation region.

  7. 47 CFR 101.85 - Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... terrestrial fixed services to the fixed-satellite service (FSS). 101.85 Section 101.85 Telecommunication... Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite service (FSS...-satellite service (FSS). The rules in this section provide for a transition period during which...

  8. 47 CFR 101.85 - Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... terrestrial fixed services to the fixed-satellite service (FSS). 101.85 Section 101.85 Telecommunication... Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite service (FSS...-satellite service (FSS). The rules in this section provide for a transition period during which...

  9. 47 CFR 101.85 - Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... terrestrial fixed services to the fixed-satellite service (FSS). 101.85 Section 101.85 Telecommunication... Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite service (FSS...-satellite service (FSS). The rules in this section provide for a transition period during which...

  10. 47 CFR 101.85 - Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... terrestrial fixed services to the fixed-satellite service (FSS). 101.85 Section 101.85 Telecommunication... Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite service (FSS...-satellite service (FSS). The rules in this section provide for a transition period during which...

  11. 47 CFR 101.85 - Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... terrestrial fixed services to the fixed-satellite service (FSS). 101.85 Section 101.85 Telecommunication... Transition of the 18.3-19.3 GHz band from the terrestrial fixed services to the fixed-satellite service (FSS...-satellite service (FSS). The rules in this section provide for a transition period during which...

  12. Bradyrhizobium japonicum NnrR, a Denitrification Regulator, Expands the FixLJ-FixK2 Regulatory Cascade

    PubMed Central

    Mesa, Socorro; Bedmar, Eulogio J.; Chanfon, Astrid; Hennecke, Hauke; Fischer, Hans-Martin

    2003-01-01

    In Bradyrhizobium japonicum, a gene named nnrR was identified which encodes a protein with high similarity to FNR/CRP-type transcriptional regulators. Mutant strains carrying an nnrR null mutation were unable to grow anaerobically in the presence of nitrate or nitrite, and they lacked both nitrate and nitrite reductase activities. Anaerobic activation of an nnrR′-′lacZ fusion required FixLJ and FixK2. In turn, N oxide-mediated induction of nir and nor genes encoding nitrite and nitric oxide reductase, respectively, depended on NnrR. Thus, NnrR expands the FixLJ-FixK2 regulatory cascade by an additional control level which integrates the N oxide signal required for maximal induction of the denitrification genes. PMID:12813094

  13. Bradyrhizobium japonicum NnrR, a denitrification regulator, expands the FixLJ-FixK2 regulatory cascade.

    PubMed

    Mesa, Socorro; Bedmar, Eulogio J; Chanfon, Astrid; Hennecke, Hauke; Fischer, Hans-Martin

    2003-07-01

    In Bradyrhizobium japonicum, a gene named nnrR was identified which encodes a protein with high similarity to FNR/CRP-type transcriptional regulators. Mutant strains carrying an nnrR null mutation were unable to grow anaerobically in the presence of nitrate or nitrite, and they lacked both nitrate and nitrite reductase activities. Anaerobic activation of an nnrR'-'lacZ fusion required FixLJ and FixK(2). In turn, N oxide-mediated induction of nir and nor genes encoding nitrite and nitric oxide reductase, respectively, depended on NnrR. Thus, NnrR expands the FixLJ-FixK(2) regulatory cascade by an additional control level which integrates the N oxide signal required for maximal induction of the denitrification genes.

  14. SU-E-T-462: Fixed-Jaw Optimization for Critical Structure Sparing in IMRT Treatment Planning: Beam Modeling Cautions for Non-Routine Use

    SciTech Connect

    Price, R; Veltchev, I; Cherian, G; Ma, C

    2014-06-01

    Purpose: Multiple publications exist concerning fixed-jaw utilization to avoid linac carriage shifts and reduce intensity modulated radiotherapy (IMRT) treatment times. The purpose of this work is to demonstrate delivery QA discrepancies and illustrate the need for improved treatment planning system (TPS) commissioning for non-routine use. Methods: A 6cm diameter spherical target was delineated on a virtual phantom containing the Iba Matrixx linear array within the Varian Eclipse TPS. Optimization was performed for target coverage for the following 3 scenarios: a single open, zero degree field where the X and Y jaws completely cover the target; the same field using an asymmetric, fixed-jaw technique where the upper Y jaw does not cover the superior 2cm of the target; and both of the aforementioned directed at the target at 315 and 45 degree gantry angles, respectively. This final orientation was also irradiated on a linac for delivery analysis. A sarcoma patient case was also analyzed where the fixed jaw technique was utilized for kidney sparing. Results: The open beam results were as predicted but the fixed-jaw results demonstrate a pronounced fluence increase along the asymmetric, upper jaw. Analysis of the delivery of the combined beam plan Resultin 83% of pixels evaluated passing gamma criteria of 3%, 3mm DTA. Analysis for the sarcoma patient, in the plane of the shielded kidney, indicated 93% passing although the maximum dose discrepancies in this region were approximately 23%. Conclusion: Optimization within the target is routinely performed using MLC leaf-end characteristics. The fixed-jaw technique forces optimization of target coverage to utilize the penumbra profiles of the associated beamdefining jaw. If the profiles were collected using a common 0.125cc ionization chamber, the resolution may be insufficient resulting in a planvs.-delivery mismatch. It is recommended that high-resolution beam characteristics be considered when non-routine planning

  15. Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions

    PubMed Central

    Luo, H; Chen, X; Singh, P; Bhattacharya, I; Jasper, P; Tolsma, JE; Jones, HM; Zutshi4, A; Abraham5, AK

    2016-01-01

    Understanding pharmacological target coverage is fundamental in drug discovery and development as it helps establish a sequence of research activities, from laboratory objectives to clinical doses. To this end, we evaluated the impact of tissue target concentration data on the level of confidence in tissue coverage predictions using a site of action (SoA) model for antibodies. By fitting the model to increasing amounts of synthetic tissue data and comparing the uncertainty in SoA coverage predictions, we confirmed that, in general, uncertainty decreases with longitudinal tissue data. Furthermore, a global sensitivity analysis showed that coverage is sensitive to experimentally identifiable parameters, such as baseline target concentration in plasma and target turnover half‐life and fixing them reduces uncertainty in coverage predictions. Overall, our computational analysis indicates that measurement of baseline tissue target concentration reduces the uncertainty in coverage predictions and identifies target‐related parameters that greatly impact the confidence in coverage predictions. PMID:27770597

  16. Detection and monitoring of microRNA expression in developing mouse brain and fixed brain cryosections.

    PubMed

    De Pietri Tonelli, Davide; Clovis, Yoanne M; Huttner, Wieland B

    2014-01-01

    MicroRNAs (miRNAs) are 20-25 nucleotide long, noncoding, and single-strand RNAs that have been found in almost all organisms and shown to exert essential roles by regulating the stability and translation of target mRNAs. In mammals most miRNAs show tissue specific and developmentally regulated expression. Approximately 70 % of all miRNAs are expressed in the brain and a growing number of studies have shown that miRNAs can modulate both brain development function and dysfunction. Moreover, miRNAs have been involved in a variety of human pathologies, including cancer and diabetes and are rapidly emerging as new potential drug targets. In order to further characterize miRNA functions, it is therefore crucial to develop techniques enabling their detection in tissues (both fixed and in vivo) with single-cell resolution. Here, we describe methods for the detection/monitoring of miRNA expression, that can be applied in both developing embryos and fixed samples, which we and others have applied to the investigation of both embryonal and postnatal neurogenesis in mice, but also in zebrafish, and cell cultures.

  17. [Dental students' opinions on education in fabricating single-tooth fixed prostheses and multi-teeth fixed prostheses].

    PubMed

    Brand, H S; Kharbanda, A; Kamell, H; Dozic, A

    2012-12-01

    Education in fabricating single-tooth fixed prostheses and multi-teeth fixed prostheses is an important component of the dental curriculum. To explore the opinion of dental students on this component of the curriculum, a web-based survey was carried out among the students of the 3 dental schools in the Netherlands. The 389 completed questionnaires revealed that the education in fabricating single-tooth fixed prostheses and multi-teeth fixed prostheses started in different years of study at the 3 dental schools. Another striking difference is that the methods of preparation and the choice of materials for single-tooth fixed prostheses and multi-teeth fixed prostheses in the pre-clinical practicum in the programmes was not the same. The students of the 3 dental schools seemed to have a reasonably positive opinion of their preclinical training preparation for treating patients. The opinions of the Nijmegen Dental School students were significantly more positive than the opinions of the students at the 2 other dental schools.

  18. An efficient floating-point to fixed-point conversion process for biometric algorithm on DaVinci DSP architecture

    NASA Astrophysics Data System (ADS)

    Konvalinka, Ira; Quddus, Azhar; Asraf, Daniel

    2009-05-01

    Today there is no direct path for the conversion of a floating-point algorithm implementation to an optimized fixed-point implementation. This paper proposes a novel and efficient methodology for Floating-point to Fixed-point Conversion (FFC) of biometric Fingerprint Algorithm Library (FAL) on fixed-point DaVinci processor. A general FFC research task is streamlined along smaller tasks which can be accomplished with lower effort and higher certainty. Formally specified in this paper is the optimization target in FFC, to preserve floating-point accuracy and to reduce execution time, while preserving the majority of algorithm code base. A comprehensive eight point strategy is formulated to achieve that target. Both local (focused on the most time consuming routines) and global optimization flow (to optimize across multiple routines) are used. Characteristic phases in the FFC activity are presented using data from employing the proposed FFC methodology to FAL, starting with target optimization specification, to speed optimization breakthroughs, finalized with validation of FAL accuracy after the execution time optimization. FAL implementation resulted in biometric verification time reduction for over a factor of 5, with negligible impact on accuracy. Any algorithm developer facing the task of implementing his floating-point algorithm on DaVinci DSP is expected to benefit from this presentation.

  19. Comparison of head-steered and aircraft-fixed infrared imagery for employing the AGM-65 Maverick missile

    NASA Astrophysics Data System (ADS)

    Osgood, Robert K.; Wells, Maxwell J.; Meador, Douglas P.

    1995-05-01

    Eight veteran USAF fighter pilots, experienced with AGM-65 Maverick air-to-ground missiles, flew a night, low-level ground attack mission in a flight simulator equipped with a helmet-mounted display (HMD). The mission was performed by delivering five Maverick missiles against ground vehicles using either an aircraft-fixed forward-looking infrared (FLIR) sensor image on a head-up display (HUD) or a head-steered FLIR as the missile aiming device. Additionally, the pilots employed their weapons by two methods: fixing and launching missiles singly or in varying numbers (multiple method). The purpose of the experiment was to determine what, if any, advantage there is to employing the AGM-65 using the HMD FLIR image to slew the missile seeker onto the target versus the conventional method of using the FLIR image displayed on the HUD. With a head-steered sensor (and fixing and launching weapons singly) subjects released their weapons quicker (14.6 second interval between launches vs. 17.1 sec.), at a higher altitude (1739 feet vs. 1603 ft.), and slightly farther from the target (3.42 nautical miles vs. 3.37 nm). Furthermore, data indicated the pilots looked farther off-boresight when searching for and locking the weapon onto a target, thereby more effectively using the full field-of-regard of the missile seeker. The participants also contributed their opinions of the advantages and disadvantages of the two mechanizations.

  20. Fixed-Rate Compressed Floating-Point Arrays.

    PubMed

    Lindstrom, Peter

    2014-12-01

    Current compression schemes for floating-point data commonly take fixed-precision values and compress them to a variable-length bit stream, complicating memory management and random access. We present a fixed-rate, near-lossless compression scheme that maps small blocks of 4(d) values in d dimensions to a fixed, user-specified number of bits per block, thereby allowing read and write random access to compressed floating-point data at block granularity. Our approach is inspired by fixed-rate texture compression methods widely adopted in graphics hardware, but has been tailored to the high dynamic range and precision demands of scientific applications. Our compressor is based on a new, lifted, orthogonal block transform and embedded coding, allowing each per-block bit stream to be truncated at any point if desired, thus facilitating bit rate selection using a single compression scheme. To avoid compression or decompression upon every data access, we employ a software write-back cache of uncompressed blocks. Our compressor has been designed with computational simplicity and speed in mind to allow for the possibility of a hardware implementation, and uses only a small number of fixed-point arithmetic operations per compressed value. We demonstrate the viability and benefits of lossy compression in several applications, including visualization, quantitative data analysis, and numerical simulation.

  1. Stray thermal influences in zinc fixed-point cells

    SciTech Connect

    Rudtsch, S.; Aulich, A.; Monte, C.

    2013-09-11

    The influence of thermal effects is a major uncertainty contribution to the calibration of Standard Platinum Resistance Thermometers (SPRTs) in fixed-point cells. Axial heat losses strongly depend on the fixed-point temperature, constructional details of cells and SPRTs and the resulting heat transfer between cell, thermometer, furnace and environment. At the zinc point contributions by heat conduction and thermal radiation must be considered. Although the measurement of temperature gradients in the re-entrant well of a fixed-point cell provides very important information about the influence of axial heat losses, further investigations are required for a reliable estimate of the resulting uncertainty contribution. It is shown that specific modifications of a zinc fixed-point cell, following generally accepted principles, may result in systematic deviations of the measured fixed-point temperatures larger than typically stated in the uncertainty budget of National Metrology Institutes (NMIs). The underlying heat transport processes are investigated and the consequences for the construction of zinc cells are discussed.

  2. Neither fixed nor random: weighted least squares meta-analysis.

    PubMed

    Stanley, T D; Doucouliagos, Hristos

    2015-06-15

    This study challenges two core conventional meta-analysis methods: fixed effect and random effects. We show how and explain why an unrestricted weighted least squares estimator is superior to conventional random-effects meta-analysis when there is publication (or small-sample) bias and better than a fixed-effect weighted average if there is heterogeneity. Statistical theory and simulations of effect sizes, log odds ratios and regression coefficients demonstrate that this unrestricted weighted least squares estimator provides satisfactory estimates and confidence intervals that are comparable to random effects when there is no publication (or small-sample) bias and identical to fixed-effect meta-analysis when there is no heterogeneity. When there is publication selection bias, the unrestricted weighted least squares approach dominates random effects; when there is excess heterogeneity, it is clearly superior to fixed-effect meta-analysis. In practical applications, an unrestricted weighted least squares weighted average will often provide superior estimates to both conventional fixed and random effects.

  3. Adaptive structures for fixed and rotary wing aircraft

    NASA Astrophysics Data System (ADS)

    Martin, Willi; Jänker, Peter; Siemetzki, Markus; Lorkowski, Thomas; Grohmann, Boris; Maier, Rudolf; Maucher, Christoph; Klöppel, Valentin; Enenkl, Bernhard; Roth, Dieter; Hansen, Heinz

    2007-07-01

    Since more than 10 years EADS Innovation Works, which is the corporate research centre of EADS (European Aeronautic Defence and Space Company), is investigating smart materials and adaptive structures for aircraft in cooperation with EADS business units. Focus of research efforts are adaptive systems for shape control, noise reduction and vibration control of both fixed and rotary wing aircraft as well as for lift optimisation of fixed wing aircraft. Two outstanding adaptive systems which have been pushed ahead in cooperation with Airbus Germany and Eurocopter Germany are adaptive servo flaps for helicopter rotor blades and innovative high lift devices for fixed wing aircraft which both were tested in flight for the first time representing world premieres. In this paper various examples of adaptive systems are presented which were developed and realized by EADS in recent years.

  4. The FTB (Flores Twin Block): a new fixed functional appliance.

    PubMed

    Rodriguez Flores, José Maria

    2010-01-01

    Functional Orthopaedics, Functionalism and their appliances have as their objective to correct the skeletal dysplasia that underlies many malocclusions, taking advantage of the potential of the stomatognathic system's strength. The range of functional appliances is very extensive and there is a great variety thereof. Basically, functional appliances can be: removable functional appliances and fixed functional appliances. In this article, we are going to present a new design for fixed functional appliances for the treatment of Class II, basing ourselves on the biomechanical principles of the Twin Block. We believe this new design, compared with other fixed functional appliances currently in use, improves patient comfort, providing a more effective response and helps us to treat our Class II cases with total success.

  5. Fixed-rate compressed floating-point arrays

    SciTech Connect

    Lindstrom, P.

    2014-03-30

    ZFP is a library for lossy compression of single- and double-precision floating-point data. One of the unique features of ZFP is its support for fixed-rate compression, which enables random read and write access at the granularity of small blocks of values. Using a C++ interface, this allows declaring compressed arrays (1D, 2D, and 3D arrays are supported) that through operator overloading can be treated just like conventional, uncompressed arrays, but which allow the user to specify the exact number of bits to allocate to the array. ZFP also has variable-rate fixed-precision and fixed-accuracy modes, which allow the user to specify a tolerance on the relative or absolute error.

  6. The proteomics of formalin-fixed wax-embedded tissue.

    PubMed

    Vincenti, David Cilia; Murray, Graeme I

    2013-04-01

    Proteomics, which is the global analysis of protein expression in cells and tissues, has emerged over the last ten to fifteen years as a key set of technologies to improve our understanding of disease processes and to identify new diagnostic, prognostic and predictive disease biomarkers. Whilst most proteomic studies have been conducted on fresh frozen tissue, the continuous improvements in technical procedures for protein extraction and separation, coupled with increasingly powerful bioinformatics, have provided the opportunity for proteomic analysis to be conducted on formalin-fixed wax-embedded tissue. This potential advance should allow proteomic analysis to be performed on the extensive archives of clinically annotated formalin fixed wax embedded tissue blocks stored in pathology departments worldwide. In this review the main techniques and their limitations involved in proteomic analysis of formalin fixed wax embedded tissue will be outlined and examples of their successful application will be indicated.

  7. Proteomic developments in the analysis of formalin-fixed tissue.

    PubMed

    Gustafsson, Ove J R; Arentz, Georgia; Hoffmann, Peter

    2015-06-01

    Retrospective proteomic studies, including those which aim to elucidate the molecular mechanisms driving cancer, require the assembly and characterization of substantial patient tissue cohorts. The difficulty of maintaining and accessing native tissue archives has prompted the development of methods to access archives of formalin-fixed tissue. Formalin-fixed tissue archives, complete with patient meta data, have accumulated for decades, presenting an invaluable resource for these retrospective studies. This review presents the current knowledge concerning formalin-fixed tissue, with descriptions of the mechanisms of formalin fixation, protein extraction, top-down proteomics, bottom-up proteomics, quantitative proteomics, phospho- and glycoproteomics as well as imaging mass spectrometry. Particular attention has been given to the inclusion of proteomic investigations of archived tumour tissue. This article is part of a Special Issue entitled: Medical Proteomics.

  8. Trajectory tracking of an underactuated fixed-wing UAV

    NASA Astrophysics Data System (ADS)

    Oland, Espen; Kristiansen, Raymond

    2014-12-01

    This paper presents a solution to the problem of trajectory tracking for a fixed-wing UAV. With its inherent actuator constraints, a fixed-wing UAV is not able to track an arbitrary trajectory, such that a guidance scheme is required in order to solve the trajectory tracking problem. In this paper, this is solved by first designing a virtual saturated control law that makes the position and velocity errors go to zero. Then the outputs from the virtual control law are mapped onto actuated variables that can be tracked using the available actuators. To that end, a model-based proportional speed controller and a quaternion-based sliding surface controller are presented, making all the errors go to zero. The solution is proved using Lyapunov theory and is validated through simulations where a fixed-wing UAV tracks a circular trajectory.

  9. Matrix product density operators: Renormalization fixed points and boundary theories

    NASA Astrophysics Data System (ADS)

    Cirac, J. I.; Pérez-García, D.; Schuch, N.; Verstraete, F.

    2017-03-01

    We consider the tensors generating matrix product states and density operators in a spin chain. For pure states, we revise the renormalization procedure introduced in (Verstraete et al., 2005) and characterize the tensors corresponding to the fixed points. We relate them to the states possessing zero correlation length, saturation of the area law, as well as to those which generate ground states of local and commuting Hamiltonians. For mixed states, we introduce the concept of renormalization fixed points and characterize the corresponding tensors. We also relate them to concepts like finite correlation length, saturation of the area law, as well as to those which generate Gibbs states of local and commuting Hamiltonians. One of the main result of this work is that the resulting fixed points can be associated to the boundary theories of two-dimensional topological states, through the bulk-boundary correspondence introduced in (Cirac et al., 2011).

  10. Border collisions inside the stability domain of a fixed point

    NASA Astrophysics Data System (ADS)

    Avrutin, Viktor; Zhusubaliyev, Zhanybai T.; Mosekilde, Erik

    2016-05-01

    Recent studies on a power electronic DC/AC converter (inverter) have demonstrated that such systems may undergo a transition from regular dynamics (associated with a globally attracting fixed point of a suitable stroboscopic map) to chaos through an irregular sequence of border-collision events. Chaotic dynamics of an inverter is not suitable for practical purposes. However, the parameter domain in which the stroboscopic map has a globally attracting fixed point has generally been considered to be uniform and suitable for practical use. In the present paper we show that this domain actually has a complicated interior structure formed by boundaries defined by persistence border collisions. We describe a simple approach that is based on symbolic dynamics and makes it possible to detect such boundaries numerically. Using this approach we describe several regions in the parameter space leading to qualitatively different output signals of the inverter although all associated with globally attracting fixed points of the corresponding stroboscopic map.

  11. A Theory of Eye Movements during Target Acquisition

    PubMed Central

    Zelinsky, Gregory J.

    2008-01-01

    The gaze movements accompanying target localization were examined via human observers and a computational model (Target Acquisition Model, TAM). Search contexts ranged from fully realistic scenes, to toys in a crib, to Os and Qs, and manipulations included set size, target eccentricity, and target-distractor similarity. Observers and the model always previewed the same targets and searched the identical displays. Behavioral and simulated eye movements were analyzed for acquisition accuracy, efficiency, and target guidance. TAM's behavior generally fell within the behavioral mean's 95% confidence interval for all measures in each experiment/condition. This agreement suggests that a fixed-parameter model using spatio-chromatic filters and a simulated retina, when driven by the correct visual routines, can be a good general purpose predictor of human target acquisition behavior. PMID:18954205

  12. Evaluation of a high performance fixed-ratio traction drive

    NASA Technical Reports Server (NTRS)

    Loewenthal, S. H.; Anderson, N. E.; Rohn, D. A.

    1980-01-01

    The results of a test program to evaluate a compact, high performance, fixed ratio traction drive are presented. This transmission, the Nasvytis Multiroller Traction Drive, is a fixed ratio, single stage planetary with two rows of stepped planet rollers. Two versions of the drive were parametrically tested back-to-back at speeds to 73,000 rpm and power levels to 180 kW (240 hp). Parametric tests were also conducted with the Nasvytis drive retrofitted to an automotive gas turbine engine. The drives exhibited good performance, with a nominal peak efficiency of 94 to 96 percent and a maximum speed loss due to creep of approximately 3.5 percent.

  13. Wavelet Transform of Fixed Pattern Noise in Focal Plane Arrays

    DTIC Science & Technology

    1994-02-01

    AD-A276 963 1111111111 I NAWCWPNS TP 8185 Wavelet Transform of Fixed Pattern Noise in Focal Plane Arrays OTIC by ELECTE Dr. Gary Hewer MAR 151994 and...REPORT TYPE AND DATES COVERED IFebruary 1994 Final; 199 ,L TTLE ND SBTILE LFUNDNG UBER Wavelet Transform of Fixed Pattern Noise in Focal Plane Arrays...nonlinearity 71,(w) = sgn(w)(IwI-t). with threshold t to each empirical sample value w in the wavelet transform d scales. After thresholding the wavelet

  14. Measurement of thermodynamic temperature of high temperature fixed points

    SciTech Connect

    Gavrilov, V. R.; Khlevnoy, B. B.; Otryaskin, D. A.; Grigorieva, I. A.; Samoylov, M. L.; Sapritsky, V. I.

    2013-09-11

    The paper is devoted to VNIIOFI's measurements of thermodynamic temperature of the high temperature fixed points Co-C, Pt-C and Re-C within the scope of the international project coordinated by the Consultative Committee for Thermometry working group 5 'Radiation Thermometry'. The melting temperatures of the fixed points were measured by a radiance mode radiation thermometer calibrated against a filter radiometer with known irradiance spectral responsivity via a high temperature black body. This paper describes the facility used for the measurements, the results and estimated uncertainties.

  15. Scanning conductance microscopy investigations on fixed human chromosomes.

    PubMed

    Clausen, Casper Hyttel; Lange, Jacob Moresco; Jensen, Linda Boye; Shah, Pranjul Jaykumar; Dimaki, Maria Ioannou; Svendsen, Winnie Edith

    2008-02-01

    Scanning conductance microscopy investigations were carried out in air on human chromosomes fixed on pre-fabricated SiO2 surfaces with a backgate. The point of the investigation was to estimate the dielectric constant of fixed human chromosomes in order to use it for microfluidic device optimization. The phase shift caused by the electrostatic forces, together with geometrical measurements of the atomic force microscopy (AFM) cantilever and the chromosomes were used to estimate a value for the dielectric constant of different human chromosomes.

  16. New hyper-Kähler manifolds by fixing monopoles

    NASA Astrophysics Data System (ADS)

    Houghton, Conor J.

    1997-07-01

    The construction of new hyper-Kähler manifolds by taking the infinite monopole mass limit of certain Bogomol'nyi-Prasad-Sommerfield monopole moduli spaces is considered. The one-parameter family of hyper-Kähler manifolds due to Dancer is shown to be an example of such manifolds. A new family of fixed monopole spaces is constructed. They are the moduli spaces of four SU4 monopoles, in the infinite mass limit of two of the monopoles. These manifolds are shown to be nonsingular when the fixed monopole positions are distinct.

  17. The effects of age-in-block on RNA-seq analysis of archival formalin-fixed paraffin-embedded (FFPE) samples

    EPA Science Inventory

    Archival samples represent a vast resource for identification of chemical and pharmaceutical targets. Previous use of formalin-fixed paraffin-embedded (FFPE) samples has been limited due to changes in RNA introduced by fixation and embedding procedures. Recent advances in RNA-seq...

  18. Drug discrimination under two concurrent fixed-interval fixed-interval schedules.

    PubMed Central

    McMillan, D E; Li, M

    2000-01-01

    Pigeons were trained to discriminate 5.0 mg/kg pentobarbital from saline under a two-key concurrent fixed-interval (FI) 100-s FI 200-s schedule of food presentation, and later tinder a concurrent FI 40-s FI 80-s schedule, in which the FI component with the shorter time requirement reinforced responding on one key after drug administration (pentobarbital-biased key) and on the other key after saline administration (saline-biased key). After responding stabilized under the concurrent FI 100-s FI 200-s schedule, pigeons earned an average of 66% (after pentobarbital) to 68% (after saline) of their reinforcers for responding under the FI 100-s component of the concurrent schedule. These birds made an average of 70% of their responses on both the pentobarbital-biased key after the training dose of pentobarbital and the saline-biased key after saline. After responding stabilized under the concurrent FI 40-s FI 80-s schedule, pigeons earned an average of 67% of their reinforcers for responding under the FI 40 component after both saline and the training dose of pentobarbital. These birds made an average of 75% of their responses on the pentobarbital-biased key after the training dose of pentobarbital, but only 55% of their responses on the saline-biased key after saline. In test sessions preceded by doses of pentobarbital, chlordiazepoxide, ethanol, phencyclidine, or methamphetamine, the dose-response curves were similar under these two concurrent schedules. Pentobarbital, chlordiazepoxide, and ethanol produced dose-dependent increases in responding on the pentobarbital-biased key as the doses increased. For some birds, at the highest doses of these drugs, the dose-response curve turned over. Increasing doses of phencyclidine produced increased responding on the pentobarbital-biased key in some, but not all, birds. After methamphetamine, responding was largely confined to the saline-biased key. These data show that pigeons can perform drug discriminations under concurrent

  19. Targeted Therapy for Cancer

    Cancer.gov

    Targeted therapy is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread. Learn how targeted therapy works against cancer and about side effects that may occur.

  20. Amplification of Herpes simplex type 1 and Human Herpes type 5 viral DNA from formalin-fixed Alzheimer brain tissue.

    PubMed

    Rodriguez, John D; Royall, Donald; Daum, Luke T; Kagan-Hallet, Kathleen; Chambers, James P

    2005-12-16

    It is known that nucleic acids from formalin-fixed tissues are not nearly as good templates for DNA amplification as those extracted from fresh tissues. However, specimens stored in most pathologic archives are initially fixed in formalin. The possibility of an infectious etiology of several diseases including Alzheimer's underscores the usefulness of archived tissue in assessing the association of infectious agents with specific pathology. In this report, we describe in detail a method resulting in robust amplification of HSV1 and Human Herpes type (HHV) 5 viral DNA targets using formalin-fixed Alzheimer brain frontal and temporal tissue as source of amplification template. Herpes simplex type 2 viral DNA was not detected in the limited samples examined in this study. Amplicons were verified by sequence analysis. Brain tissue stored in formalin longer than 1 year prior to post-formalin-fixation analysis gave rise to significantly shorter amplicons consistent with the observation that template DNA integrity decreases significantly with increasing time of storage in formalin. Thus, this report should be useful in PCR-based investigations assessing the regional presence of viral DNAs in formalin-fixed brain tissue.

  1. MALDI imaging mass spectrometry of N-linked glycans on formalin-fixed paraffin-embedded murine kidney.

    PubMed

    Gustafsson, Ove J R; Briggs, Matthew T; Condina, Mark R; Winderbaum, Lyron J; Pelzing, Matthias; McColl, Shaun R; Everest-Dass, Arun V; Packer, Nicolle H; Hoffmann, Peter

    2015-03-01

    Recent developments in spatial proteomics have paved the way for retrospective in situ mass spectrometry (MS) analyses of formalin-fixed paraffin-embedded clinical tissue samples. This type of analysis is commonly referred to as matrix-assisted laser desorption/ionization (MALDI) imaging. Recently, formalin-fixed paraffin-embedded MALDI imaging analyses were augmented to allow in situ analyses of tissue-specific N-glycosylation profiles. In the present study, we outline an improved automated sample preparation method for N-glycan MALDI imaging, which uses in situ PNGase F-mediated release and measurement of N-linked glycans from sections of formalin-fixed murine kidney. The sum of the presented data indicated that N-glycans can be cleaved from proteins within formalin-fixed tissue and characterized using three strategies: (i) extraction and composition analysis through on-target MALDI MS and liquid chromatography coupled to electrospray ionization ion trap MS; (ii) MALDI profiling, where N-glycans are released and measured from large droplet arrays in situ; and (iii) MALDI imaging, which maps the tissue specificity of N-glycans at a higher resolution. Thus, we present a complete, straightforward method that combines MALDI imaging and characterization of tissue-specific N-glycans and complements existing strategies.

  2. Protocol for HER2 FISH determination on PAXgene-fixed and paraffin-embedded tissue in breast cancer.

    PubMed

    Oberauner-Wappis, Lisa; Loibner, Martina; Viertler, Christian; Groelz, Daniel; Wyrich, Ralf; Zatloukal, Kurt

    2016-04-01

    Molecular diagnostics in personalized medicine increasingly relies on the combination of a variety of analytical technologies to characterize individual diseases and to select patients for targeted therapies. The gold standard for tissue-based diagnostics is fixation in formalin and embedding in paraffin, which results in excellent preservation of morphology but negatively impacts on a variety of molecular assays. The formalin-free, non-cross-linking PAXgene tissue system preserves morphology in a similar way to formalin, but also preserves biomolecules essentially in a similar way to cryopreservation, which markedly widens the spectrum, sensitivity and accuracy of molecular analytics. In this study, we have developed and tested a protocol for PAXgene-fixed and paraffin-embedded tissues for fluorescent in situ hybridization (FISH). The implementation of a 24-h formalin postfixation step of slides from PAXgene-fixed and paraffin-embedded tissues allowed us to use the assays approved for formalin-fixed and paraffin-embedded tissues. The equivalence of the methodologies was demonstrated by FISH analysis of HER2 amplification in breast cancer cases. The 24-h postfixation step of the slides used for FISH can be well integrated in the routine diagnostic workflow and allows the remaining PAXgene-fixed and paraffin-embedded tissue to be used for further molecular testing.

  3. 40 CFR 63.1042 - Standards-Separator fixed roof.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) National Emission Standards for Oil-Water Separators and Organic-Water Separators § 63.1042 Standards... controlling air emissions from an oil-water separator or organic-water separator using a fixed roof. (b) The... are no visible cracks, holes, gaps, or other open spaces between roof section joints or between...

  4. 40 CFR 63.1042 - Standards-Separator fixed roof.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) National Emission Standards for Oil-Water Separators and Organic-Water Separators § 63.1042 Standards... controlling air emissions from an oil-water separator or organic-water separator using a fixed roof. (b) The... are no visible cracks, holes, gaps, or other open spaces between roof section joints or between...

  5. Group Search Optimization for Fixed Head Hydrothermal Power System

    NASA Astrophysics Data System (ADS)

    Jena, Chitralekha; Basu, Mousumi

    2017-02-01

    This paper presents group search optimization for optimal scheduling of thermal plants in coordination with fixed head hydro units. Numerical results for two test systems have been presented to demonstrate the performance of the proposed method. Results obtained from the proposed group search optimization method have been compared with those obtained from differential evolution and evolutionary programming.

  6. Review of "Spend Smart: Fix Our Broken School Funding System"

    ERIC Educational Resources Information Center

    Baker, Bruce

    2011-01-01

    ConnCAN's Spend Smart: "Fix Our Broken School Funding System" was released concurrently with a bill introduced in the Connecticut legislature, based on the principles outlined in the report. However, the report is of negligible value to the policy debate over Connecticut school finance because it provides little or no support for any of…

  7. Design of a nonscaling fixed field alternating gradient accelerator

    NASA Astrophysics Data System (ADS)

    Trbojevic, D.; Courant, E. D.; Blaskiewicz, M.

    2005-05-01

    We present a design of nonscaling fixed field alternating gradient accelerators (FFAG) minimizing the dispersion action function H. The design is considered both analytically and via computer modeling. We present the basic principles of a nonscaling FFAG lattice and discuss optimization strategies so that one can accelerate over a broad range of momentum with reasonable apertures. Acceleration schemes for muons are discussed.

  8. Radon gas, useful for medical purposes, safely fixed in quartz

    NASA Technical Reports Server (NTRS)

    Fields, P. R.; Stein, L.; Zirin, M. H.

    1966-01-01

    Radon gas is enclosed in quartz or glass ampules by subjecting the gas sealed at a low pressure in the ampules to an ionization process. This process is useful for preparing fixed radon sources for radiological treatment of malignancies, without the danger of releasing radioactive gases.

  9. Modularity of a carbon-fixing protein organelle.

    PubMed

    Bonacci, Walter; Teng, Poh K; Afonso, Bruno; Niederholtmeyer, Henrike; Grob, Patricia; Silver, Pamela A; Savage, David F

    2012-01-10

    Bacterial microcompartments are proteinaceous complexes that catalyze metabolic pathways in a manner reminiscent of organelles. Although microcompartment structure is well understood, much less is known about their assembly and function in vivo. We show here that carboxysomes, CO(2)-fixing microcompartments encoded by 10 genes, can be heterologously produced in Escherichia coli. Expression of carboxysomes in E. coli resulted in the production of icosahedral complexes similar to those from the native host. In vivo, the complexes were capable of both assembling with carboxysomal proteins and fixing CO(2). Characterization of purified synthetic carboxysomes indicated that they were well formed in structure, contained the expected molecular components, and were capable of fixing CO(2) in vitro. In addition, we verify association of the postulated pore-forming protein CsoS1D with the carboxysome and show how it may modulate function. We have developed a genetic system capable of producing modular carbon-fixing microcompartments in a heterologous host. In doing so, we lay the groundwork for understanding these elaborate protein complexes and for the synthetic biological engineering of self-assembling molecular structures.

  10. METHOD OF FIXING NITROGEN FOR PRODUCING OXIDES OF NITROGEN

    DOEpatents

    Harteck, P.; Dondes, S.

    1959-08-01

    A method is described for fixing nitrogen from air by compressing the air, irradiating the compressed air in a nuclear reactor, cooling to remove NO/ sub 2/, compressing the cooled gas, further cooling to remove N/sub 2/O and recirculating the cooled compressed air to the reactor.

  11. 46 CFR 193.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... brake horsepower (b.h.p.) or greater, or their fuel oil units, including purifiers, valves, and... oil fired boilers or their associated fuel oil units, valves, or manifolds in the line between the... and paint lockers, oil rooms, and similar spaces. (b) A fixed carbon dioxide or clean agent...

  12. 20 CFR 726.105 - Fixing the amount of security.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...'S INSURANCE Authorization of Self-Insurers § 726.105 Fixing the amount of security. The Office shall... security required, the factors that the Office will consider include, but are not limited to, the operator... liability for benefits. The Office shall also consider such other factors as it considers relevant to...

  13. 29 CFR 1910.160 - Fixed extinguishing systems, general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... non-corrosive material or otherwise protected against corrosion. (13) Automatic detection equipment... all fixed extinguishing systems installed to meet a particular OSHA standard except for automatic... no employee exposure are exempted from the requirements of this section. (b) General requirements....

  14. 29 CFR 1910.160 - Fixed extinguishing systems, general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... non-corrosive material or otherwise protected against corrosion. (13) Automatic detection equipment... all fixed extinguishing systems installed to meet a particular OSHA standard except for automatic... no employee exposure are exempted from the requirements of this section. (b) General requirements....

  15. 29 CFR 1910.160 - Fixed extinguishing systems, general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... non-corrosive material or otherwise protected against corrosion. (13) Automatic detection equipment... all fixed extinguishing systems installed to meet a particular OSHA standard except for automatic... no employee exposure are exempted from the requirements of this section. (b) General requirements....

  16. 29 CFR 1910.160 - Fixed extinguishing systems, general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... non-corrosive material or otherwise protected against corrosion. (13) Automatic detection equipment... all fixed extinguishing systems installed to meet a particular OSHA standard except for automatic... no employee exposure are exempted from the requirements of this section. (b) General requirements....

  17. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... salary for fluctuating hours. (a) An employee employed on a salary basis may have hours of work which fluctuate from week to week and the salary may be paid him pursuant to an understanding with his...

  18. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... salary for fluctuating hours. (a) An employee employed on a salary basis may have hours of work which fluctuate from week to week and the salary may be paid him pursuant to an understanding with his...

  19. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... salary for fluctuating hours. (a) An employee employed on a salary basis may have hours of work which fluctuate from week to week and the salary may be paid him pursuant to an understanding with his...

  20. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... salary for fluctuating hours. (a) An employee employed on a salary basis may have hours of work which fluctuate from week to week and the salary may be paid him pursuant to an understanding with his...

  1. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... salary for fluctuating hours. (a) An employee employed on a salary basis may have hours of work which fluctuate from week to week and the salary may be paid him pursuant to an understanding with his...

  2. Occlusion in the combination fixed removable prosthodontic patient.

    PubMed

    Ivanhoe, J R; Vaught, R D

    1987-07-01

    The authors provide a review of the critical aspects of occlusion for the combination fixed removable patient. Articular selection and jaw relation techniques are reviewed, and dental materials combinations are recommended for restoring opposing occlusal surfaces. General objectives and specific recommendations for determining and establishing occlusal schemes are made. Tables outlining occlusal scheme, occlusal morphology, and degree of balance are presented.

  3. 33 CFR 164.41 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Electronic position fixing devices. 164.41 Section 164.41 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.41 Electronic...

  4. 50 CFR 660.372 - Fixed gear sablefish fishery management.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to the primary season for the fixed gear limited entry sablefish fishery north of 36° N. lat., except for paragraph (c), of this section, which also applies to the open access fishery north of 36° N. lat. and to both the limited entry and open access fisheries south of 36° N. lat. Limited entry and...

  5. Fixed Group and Opportunistic Collaboration in a CSCL Environment

    ERIC Educational Resources Information Center

    Siqin, Tuya; van Aalst, Jan; Chu, Samuel Kai Wah

    2015-01-01

    This study investigated synchronous discourses involving student collaboration in fixed groups during an introductory research methods course's first 8-week phase, and opportunistic collaboration during its second 8-week phase. Twenty-seven Chinese undergraduates participated in online discourse on Knowledge Forum as part of the course. A…

  6. Fixed- and Variable-Ratio Reinforcement of Reading Performance.

    ERIC Educational Resources Information Center

    George, John E.

    The effects of fixed-ratio and variable-ratio reinforcement classroom reading performance was investigated. Subjects were 50 boys and 50 girls from four grade-2 classrooms of one elementary school. The subjects were divided into three reading levels, above-average, average, and below-average, and were randomly assigned to (1) a no-reinforcement…

  7. 33 CFR 118.65 - Lights on fixed bridges.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... bridge span structure so as to be visible from an approaching vessel. Each red light shall show through a... securely mounted on the bridge structure and spaced as nearly 15 feet apart as the structure of the bridge... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Lights on fixed bridges....

  8. 33 CFR 118.65 - Lights on fixed bridges.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... bridge span structure so as to be visible from an approaching vessel. Each red light shall show through a... securely mounted on the bridge structure and spaced as nearly 15 feet apart as the structure of the bridge... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on fixed bridges....

  9. 33 CFR 118.65 - Lights on fixed bridges.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... bridge span structure so as to be visible from an approaching vessel. Each red light shall show through a... securely mounted on the bridge structure and spaced as nearly 15 feet apart as the structure of the bridge... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Lights on fixed bridges....

  10. 33 CFR 118.65 - Lights on fixed bridges.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... bridge span structure so as to be visible from an approaching vessel. Each red light shall show through a... securely mounted on the bridge structure and spaced as nearly 15 feet apart as the structure of the bridge... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Lights on fixed bridges....

  11. Multigrid convergence of inviscid fixed- and rotary-wing flows

    NASA Astrophysics Data System (ADS)

    Allen, C. B.

    2002-05-01

    The affect of multigrid acceleration implemented within an upwind-biased Euler method is presented, and applied to fixed-wing and rotary-wing flows. The convergence of fixed- and rotary-wing computations is shown to be vastly different, and multigrid is shown to be less effective for rotary-wing flows. The flow about a hovering rotor suffers from very slow convergence of the inner blade region, where the flow is effectively incompressible. Furthermore, the vortical wake must develop over several turns before convergence is achieved, whereas for fixed-wing computations the far-field grid and solution have little significance. Results are presented for single mesh and two, three, four, and five level multigrid, and using five levels a reduction in required CPU time of over 80 per cent is demonstrated for rotary-wing computations, but 94 per cent for fixed-wing computations. It is found that a simple V-cycle is the most effective, smoothing in the decreasing mesh density direction only, with a relaxed trilinear prolongation operator. Copyright

  12. The Structure of Memory: Fixed of Flexible? Structural Learning Series.

    ERIC Educational Resources Information Center

    Scandura, Joseph M.

    Most current information processing theories of cognition and memory share one common feature: the structure (state-space) of memory is fixed and retrieval from memory involves searching through that structure. Learning, where it is treated at all, involves transforming one such structure into another. This form of representation is questioned and…

  13. 50 CFR 660.211 - Fixed gear fishery-definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... both north and south of 36° N. lat. that is subject to trip limit restrictions including daily and/or... fishery or sablefish tier limit fishery means, for the limited entry fixed gear sablefish fishery north of 36° N. lat, the fishery where vessels registered to at least one limited entry permit with both...

  14. A Comparative Study of IRT Fixed Parameter Calibration Methods

    ERIC Educational Resources Information Center

    Kim, Seonghoon

    2006-01-01

    This article provides technical descriptions of five fixed parameter calibration (FPC) methods, which were based on marginal maximum likelihood estimation via the EM algorithm, and evaluates them through simulation. The five FPC methods described are distinguished from each other by how many times they update the prior ability distribution and by…

  15. Fixed Point Problems for Linear Transformations on Pythagorean Triples

    ERIC Educational Resources Information Center

    Zhan, M.-Q.; Tong, J.-C.; Braza, P.

    2006-01-01

    In this article, an attempt is made to find all linear transformations that map a standard Pythagorean triple (a Pythagorean triple [x y z][superscript T] with y being even) into a standard Pythagorean triple, which have [3 4 5][superscript T] as their fixed point. All such transformations form a monoid S* under matrix product. It is found that S*…

  16. 46 CFR 95.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Alternately, the Commandant may permit the installation of an approved water sprinkler system or other... 46 Shipping 4 2010-10-01 2010-10-01 false Fixed fire extinguishing systems. 95.05-10 Section 95.05... fire extinguishing systems. (a) Approved fire extinguishing systems may be used or required...

  17. Estimation of Spatial Dynamic Nonparametric Durbin Models with Fixed Effects

    ERIC Educational Resources Information Center

    Qian, Minghui; Hu, Ridong; Chen, Jianwei

    2016-01-01

    Spatial panel data models have been widely studied and applied in both scientific and social science disciplines, especially in the analysis of spatial influence. In this paper, we consider the spatial dynamic nonparametric Durbin model (SDNDM) with fixed effects, which takes the nonlinear factors into account base on the spatial dynamic panel…

  18. Generalized Bullous Fixed Drug Eruption due to Bromhexine.

    PubMed

    Vide, J; Moreira, C; Cunha, A P; Baldaia, H; Magina, S; Azevedo, F

    2016-07-15

    We describe a patient with a generalized bullous form of Fixed Drug Eruption (FDE) induced by bromhexine, a commonly used drug for respiratory symptoms. This is a rare association and generalized bullous FDE is also very rare. We emphasize the importance of patch tests in identifying the culprit drug.

  19. A fast triple patterning solution with fix guidance

    NASA Astrophysics Data System (ADS)

    Fang, Weiping; Arikati, Srini; Cilingir, Erdem; Hug, Marco A.; De Bisschop, Peter; Mailfert, Julien; Lucas, Kevin; Gao, Weimin

    2014-03-01

    Logic manufacturers are looking towards a triple patterning solution for their 10nm node Metal1 layer, and possibly for Via0, and local interconnect layers. Given the NP-completeness for the 3-colorability problem, a challenge is how to go beyond a standard cell to efficiently decompose a layout at a block or chip level. Using decomposed or pre-colored standard cells does not always mean decomposable standard cell layouts can be placed next to each other. Posing constraints on how cells can be placed next to each other could cause area loss. A preferred way is to perform the decomposition at a block or chip level. We have successfully developed a triple patterning decomposition methodology that can effectively decompose an entire layout block or a chip. Formulating a triple patterning decomposition problem into a graph 3-color problem, the system first builds a graph to represent the layout. It then tries to reduce and partition the graph without changing its 3-colorability property. To color the reduced graph, we adopt a hybrid approach with a fast heuristic for coloring and an exact coloring algorithm for backup and conflict verification. Unlike an odd cycle in double patterning, a triple patterning coloring conflict can't be represented in a single loop. Another challenge for triple patterning is then how to report errors that the user can effectively use to fix them. For this purpose, minimum fix guidance - minimum to fix a conflict, and maximal minimum fix guidance - maximal choices are presented.

  20. Partial rectangular metric spaces and fixed point theorems.

    PubMed

    Shukla, Satish

    2014-01-01

    The purpose of this paper is to introduce the concept of partial rectangular metric spaces as a generalization of rectangular metric and partial metric spaces. Some properties of partial rectangular metric spaces and some fixed point results for quasitype contraction in partial rectangular metric spaces are proved. Some examples are given to illustrate the observed results.