Science.gov

Sample records for 1996-97 fixed target

  1. The Indigenous World, 1996-97 = El Mundo Indigena, 1996-97.

    ERIC Educational Resources Information Center

    Erni, Christian, Ed.

    This annual publication (published separately in English and Spanish) examines political, legal, social, and educational issues concerning indigenous peoples around the world during 1996-97. Part I highlights news events and ongoing situations in specific countries. In North America, these include threats of proposed oil drilling on sacred sites…

  2. Event parameters - fixed target

    SciTech Connect

    Poskanzer, A.; Ritter, H.G.; Ludewigt, B.; Foley, K.; Borenstein, S.; Platner, E.; Love, W.; Keane, D.; Plasil, F.

    1984-06-15

    This subgroup has focussed on detectors for fixed target experiments which have full azimuthal coverage. The general scope of the working group was to consider (1) the configuration of an idealized detector, and (2) various configurations of practical detectors that could be implemented on a relatively short time scale. The second category includes possible upgrades and modifications of existing experimental facilities. Beams of both 15 GeV/A sulphur at the AGS and 200 GeV/A oxygen at the SPS were considered.

  3. Running Start Annual Progress Report, 1996-97.

    ERIC Educational Resources Information Center

    Crossland, Ron

    The Running Start program was created by the 1990 Washington State Legislature to expand educational options for public school students. Running Start allows eleventh and twelfth grade high school students to take college-level courses, tuition-free, at the 32 community and technical colleges in Washington. This annual progress report for 1996-97

  4. Pennsylvania College of Technology Sourcebook, 1996-97.

    ERIC Educational Resources Information Center

    Cunningham, Stephen

    This report provides a statistical profile of Pennsylvania College of Technology (PCT) and its service area for 1996-97. The first two sections provide a profile and history of the college, organizational charts, and a description of the governance system. Section III provides tables on students, including numbers of applications, enrollments, and…

  5. Annual Report: Doctoral Program Committee, Academic Year 1996-97.

    ERIC Educational Resources Information Center

    Lievrouw, Leah A.; Leazer, Greg; Lynch, Beverly; Abler, Susan; Mediavilla, Cynthia

    This document summarizes the activities of the University of California, Los Angeles's (UCLA's) Department of Library and Information Science (DLIS) Doctoral Program Committee, 1996-97. These activities are organized into two main areas: Operations and Students. Doctoral Program Committee (DPC) operations outlined include: preparing major policy…

  6. Bilingual Program Evaluation Report on Academic Assessments, 1996-97.

    ERIC Educational Resources Information Center

    Sarangarm, Isara

    This report summarizes academic assessment data for Las Cruces (New Mexico) Public Schools bilingual students in 1996-97. It has eight sections: (1) results of the Iowa Test of Basic Skills for third, fifth, and eighth grade students; (2) results of the La Prueba tests for grades three, five, and eight; (3) results of the New Mexico High School…

  7. The Fact Book 1996-97. A Statistical Handbook.

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, Baltimore.

    This handbook presents statistics about public and private schools in Maryland in the 1996-97 school year. In 1996, Maryland schools had an average daily membership of 800,610.4 students, with an average daily attendance of 747,468.4 students. These students, who attended 1,284 public schools and 1,105 nonpublic schools, were served by 88,465…

  8. 34 CFR 668.155 - Transitional rule for the 1996-97 award year.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Transitional rule for the 1996-97 award year. 668.155... the 1996-97 award year. (a) Notwithstanding any other provision of this part, an institution may... was an approved test as of June 30, 1996, and the passing score on that test, until 60 days after...

  9. Fixed target flammable gas upgrades

    SciTech Connect

    Schmitt, R.; Squires, B.; Gasteyer, T.; Richardson, R.

    1996-12-01

    In the past, fixed target flammable gas systems were not supported in an organized fashion. The Research Division, Mechanical Support Department began to support these gas systems for the 1995 run. This technical memo describes the new approach being used to supply chamber gasses to fixed target experiments at Fermilab. It describes the engineering design features, system safety, system documentation and performance results. Gas mixtures provide the medium for electron detection in proportional and drift chambers. Usually a mixture of a noble gas and a polyatomic quenching gas is used. Sometimes a small amount of electronegative gas is added as well. The mixture required is a function of the specific chamber design, including working voltage, gain requirements, high rate capability, aging and others. For the 1995 fixed target run all the experiments requested once through gas systems. We obtained a summary of problems from the 1990 fixed target run and made a summary of the operations logbook entries from the 1991 run. These summaries primarily include problems involving flammable gas alarms, but also include incidents where Operations was involved or informed. Usually contamination issues were dealt with by the experimenters. The summaries are attached. We discussed past operational issues with the experimenters involved. There were numerous incidents of drift chamber failure where contaminated gas was suspect. However analyses of the gas at the time usually did not show any particular problems. This could have been because the analysis did not look for the troublesome component, the contaminant was concentrated in the gas over the liquid and vented before the sample was taken, or that contaminants were drawn into the chambers directly through leaks or sub-atmospheric pressures. After some study we were unable to determine specific causes of past contamination problems, although in argon-ethane systems the problems were due to the ethane only.

  10. Basic Facts about Wisconsin Elementary and Secondary Schools, 1996-97.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison.

    The tables in this compilation provide information about Wisconsin's 426 public school districts, their 2,063 schools, and 988 private schools in the state. In 1996-97, Wisconsin public schools served more than 879,000 students and private schools enrolled just over 150,000. Data are presented in a series of tables grouped into the following…

  11. Report on Hate Crimes & Discrimination against Arab Americans, 1996-97.

    ERIC Educational Resources Information Center

    American Arab Anti Discrimination Committee, Washington, DC.

    Examples of hate crimes against Arab Americans in this report are those that were reported to the American-Arab Anti-Discrimination Committee (ADC), but the actual number of hate crimes and incidents of discrimination far exceeds those reported. As the report shows, Arab American civil rights were increasingly threatened in 1996-97 by the…

  12. Dengue epidemic in Belém, Pará, Brazil, 1996-97.

    PubMed

    Trravassos da Rosa, A P; Vasconcelos, P F; Travassos Da Rosa, E S; Rodrigues, S G; Mondet, B; Cruz, A C; Sousa, M R; Travassos Da Rosa, J F

    2000-01-01

    We describe clinical and epidemiologic findings during the first epidemic of dengue fever in Belém, Pará State, Brazil, in 1996-97. Of 40,237 serum samples, 17,440 (43%) were positive for dengue by virus isolation or serologic testing. No hemorrhagic cases or deaths were reported. Mycobacterium tuberculosis

  13. The 1994 Fermilab Fixed Target Program

    SciTech Connect

    Conrad, J. |

    1994-11-01

    This paper highlights the results of the Fermilab Fixed Target Program that were announced between October, 1993 and October, 1994. These results are drawn from 18 experiments that took data in the 1985, 1987 and 1990/91 fixed target running periods. For this discussion, the Fermilab Fixed Target Program is divided into 5 major topics: hadron structure, precision electroweak measurements, heavy quark production, polarization and magnetic moments, and searches for new phenomena. However, it should be noted that most experiments span several subtopics. Also, measurements within each subtopic often affect the results in other subtopics. For example, parton distributions from hadron structure measurements are used in the studies of heavy quark production.

  14. Fixed-target physics at Fermilab

    SciTech Connect

    Bjorken, J.D.

    1985-03-01

    The Fermilab Energy Saver is now successfully commissioned and fixed-target experimentation at high energy (800 GeV) has begun. In addition, a number of new experiments designed to exploit the unique features of the Tevatron are yet to come on-line. In this talk, we will review recent accomplishments in the fixed-target program and describe experiments in progress and others yet to come.

  15. Fixed target facility at the SSC

    SciTech Connect

    Loken, S.C.; Morfin, J.G.

    1985-01-01

    The question of whether a facility for fixed target physics should be provided at the SSC must be answered before the final technical design of the SSC can be completed, particularly if the eventual form of extraction would influence the magnet design. To this end, an enthusiastic group of experimentalists, theoreticians and accelerator specialists have studied this point. The accelerator physics issues were addressed by a group led by E. Colton whose report is contained in these proceedings. The physics addressable by fixed target was considered by many of the Physics area working groups and in particular by the Structure Function Group. This report is the summary of the working group which considered various SSC fixed target experiments and determined which types of beams and detectors would be required. 13 references, 5 figures.

  16. Landslides triggered by the winter 1996-97 storms in the Puget Lowland, Washington

    USGS Publications Warehouse

    Baum, Rex L.; Chleborad, Alan F.; Schuster, Robert L.

    1998-01-01

    Snowmelt and rainfall events triggered many landslides and debris flows in the Seattle, Washington, area during late December 1996 and January and March 1997. Landslides caused the deaths of at least four people, millions of dollars in damage to public and private property, lost revenues, traffic diversions, and other direct and indirect losses. Although shallow slides and debris flows were the most common slope failures, many deep-seated slides also occurred. Comparing maps that show distribution of historic landslides with reports of landslides compiled by city and county governments for the winter of 1996-97 and our field reconnaissance of recent landslide deposits and scars indicates that many bluffs and steep hillsides are sites of recurring failures. Investigation of the 1996-97 landslides indicates that houses and other structures built downslope from steep bluffs are in particular danger of impact by debris flows, while those on the benches, slopes, or rim of bluffs are subject to severe damage by deep slides.

  17. Fixed Target Beauty Physics Experimental Programs

    SciTech Connect

    Garbincius, P.H.

    1987-11-01

    The current and near term future fixed target physics efforts in observing particles with open beauty are reviewed. This includes a compilation of the non-observation upper limits and the observation of both upsilon and b-states. A short discussion of the theoretical predictions for the hadro-produced beauty pairs is included. The major part of this review is devoted to the techniques and tricks employed, a survey of the current and proposed experiments. A personal summary of the experimental prospects concludes this report. 28 refs., 26 figs.

  18. Fixed target experiments at the Fermilab Tevatron

    SciTech Connect

    Gutierrez, Gaston; Reyes, Marco A.

    2014-11-10

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of √s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include π⁺π⁻, K⁰s K⁰s, K⁰s K±π, φφ and D. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D.

  19. Fixed target experiments at the Fermilab Tevatron

    DOE PAGES

    Gutierrez, Gaston; Reyes, Marco A.

    2014-11-10

    This paper presents a review of the study of Exclusive Central Production at a Center of Mass energy of √s = 40 GeV at the Fermilab Fixed Target program. In all reactions reviewed in this paper, protons with an energy of 800 GeV were extracted from the Tevatron accelerator at Fermilab and directed to a Liquid Hydrogen target. The states reviewed include π⁺π⁻, K⁰s K⁰s, K⁰s K±π∓, φφ and D*±. Partial Wave Analysis results will be presented on the light states but only the cross-section will be reviewed in the diffractive production of D*±.

  20. Charm and beauty measurements at Fermilab fixed target

    SciTech Connect

    Mishra, C.S.

    1993-10-01

    Eighteen months after a successful run of the Fermilab fixed target program, interesting results from several experiments are available. This is the first time that more than one Fermilab fixed target experiment has reported the observation of beauty mesons. In this paper we review recent results from charm and beauty fixed target experiments at Fermilab.

  1. Fixed-target hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2015-08-01

    Results from fixed-target hadroproduction experiments (HARP, MIPP, NA49 and NA61/SHINE) as well as their implications for cosmic ray and neutrino physics are reviewed. HARP measurements have been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve predictions of the muon yields in EAS and of the atmospheric neutrino fluxes as well as to help in the optimization of neutrino factory and super-beam designs. Recent measurements released by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment and for interpretation of EAS data. These hadroproduction experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  2. Salary-Trend Study of Faculty in Social Work for the Years 1996-97 and 1999-00.

    ERIC Educational Resources Information Center

    Howe, Richard D.

    This report is part of an annual national survey that examines salaries of full-time teaching faculty in 54 selected academic disciplines. Data for the study were collected from a total of 296 public and 390 private four-year institutions from the baseline year of 1996-97 to the trend year of 1999-2000. A data table lists average salaries for both…

  3. Review of calorimetry in Fermilab fixed-target experiments

    SciTech Connect

    Crisler, M.B.

    1995-04-01

    The fixed-target program at Fermilab comprises as many as thirteen simultaneous experiments in ten separate beamlines using beams of primary protons, pions, kaons, electrons, neutrinos, and muons. The fixed target beamlines were last in operation in the latter half of 1991, shutting down in 1992. The next fixed target run is scheduled for early 1996. This article describes some of the wide variety of calorimetric devices that were in use in the past run or to be used in the coming run. Special attention is devoted to the new devices currently under construction.

  4. Mechanism of the 1996-97 non-eruptive volcano-tectonic earthquake swarm at Iliamna Volcano, Alaska

    USGS Publications Warehouse

    Roman, D.C.; Power, J.A.

    2011-01-01

    A significant number of volcano-tectonic(VT) earthquake swarms, some of which are accompanied by ground deformation and/or volcanic gas emissions, do not culminate in an eruption.These swarms are often thought to represent stalled intrusions of magma into the mid- or shallow-level crust.Real-time assessment of the likelihood that a VTswarm will culminate in an eruption is one of the key challenges of volcano monitoring, and retrospective analysis of non-eruptive swarms provides an important framework for future assessments. Here we explore models for a non-eruptive VT earthquake swarm located beneath Iliamna Volcano, Alaska, in May 1996-June 1997 through calculation and inversion of fault-plane solutions for swarm and background periods, and through Coulomb stress modeling of faulting types and hypocenter locations observed during the swarm. Through a comparison of models of deep and shallow intrusions to swarm observations,we aim to test the hypothesis that the 1996-97 swarm represented a shallow intrusion, or "failed" eruption.Observations of the 1996-97 swarm are found to be consistent with several scenarios including both shallow and deep intrusion, most likely involving a relatively small volume of intruded magma and/or a low degree of magma pressurization corresponding to a relatively low likelihood of eruption. ?? 2011 Springer-Verlag.

  5. Beauty and charm production in fixed target experiments

    SciTech Connect

    Kidonakis, Nikolaos; Vogt, Ramona

    2004-05-01

    We present calculations of NNLO threshold corrections for beauty and charm production in {pi}{sup -} p and pp interactions at fixed-target experiments. Recent calculations for heavy quark hadroproduction have included next-to-next-to-leading-order (NNLO) soft-gluon corrections [1] to the double differential cross section from threshold resummation techniques [2]. These corrections are important for near-threshold beauty and charm production at fixed-target experiments, including HERA-B and some of the current and future heavy ion experiments.

  6. Test beams and polarized fixed target beams at the NLC

    NASA Astrophysics Data System (ADS)

    Keller, Lewis; Pitthan, Rainer; Rokni, Sayed; Thompson, Kathleen; Kolomensky, Yury

    2001-07-01

    A conceptual program to use NLC beams for test beams and fixed target physics is described. Primary undisrupted polarized beams would be the most simple to use, but for NLC, the disrupted beams are of good enough quality that they could also be used, after collimation of the low energy tails, for test beams and fixed target physics. Pertinent issues are: what is the compelling physics, what are the requirements on beams and running time, and what is the impact on colliding beam physics running. A list of physics topics is given; one topic (Mo/ller Scattering) is treated in more depth.

  7. Energy spectra of protons, deuterium, and helium nuclei during quiet solar activity periods in 1996-97

    NASA Astrophysics Data System (ADS)

    Kecskemety, Karoly

    A background reduction method based on pulse-height analysis (see accompanying paper by Valtonen et al.) is applied for the data of the ERNE and EPHIN energetic particle telescopes aboard SOHO. Energy spectra of protons, deuterons, 3He and 4He nuclei have been obtained during very low activity periods in 1996-97 in the energy range of 1.3 to 22 MeV/n. The proton spectra are comparable to the lowest spectra of the Ulysses (COSPIN/LET, 1996) and near-Earth IMP-8 (1985-87) measurements. Deuterons and 3He are only significantly seen above about 10 MeV/n, their spectra are consistent with an increase proportional to kinetic energy, expected for purely galactic origin.

  8. Pyroclastic flows generated by gravitational instability of the 1996-97 lava dome of Soufriere Hills Volcano, Montserrat

    USGS Publications Warehouse

    Cole, P.D.; Calder, E.S.; Druitt, T.H.; Hoblitt, R.; Robertson, R.; Sparks, R.S.J.; Young, S.R.

    1998-01-01

    Numerous pyroclastic flows were produced during 1996-97 by collapse of the growing andesitic lava dome at Soufriere Hills Volcano, Montserrat. Measured deposit volumes from these flows range from 0.2 to 9 ?? 106 m3. Flows range from discrete, single pulse events to sustained large scale dome collapse events. Flows entered the sea on the eastern and southern coasts, depositing large fans of material at the coast. Small runout distance (<1 km) flows had average flow front velocities in the order of 3-10 m/s while flow fronts of the larger runout distance flows (up to 6.5 km) advanced in the order of 15-30 m/s. Many flows were locally highly erosive. Field relations show that development of the fine grained ash cloud surge component was enhanced during the larger sustained events. Periods of elevated pyroclastic flow productivity and sustained dome collapse events are linked to pulses of high magma extrusion rates.Numerous pyroclastic flows were produced during 1996-97 by collapse of the growing andesitic lava dome at Soufriere Hills Volcano, Montserrat. Measured deposit volumes from these flows range from 0.2 to 9??106 m3. Flows range from discrete, single pulse events to sustained large scale dome collapse events. Flows entered the sea on the eastern and southern coasts, depositing large fans of material at the coast. Small runout distance (<1 km) flows had average flow front velocities in the order of 3-10 m/s while flow fronts of the larger runout distance flows (up to 6.5 km) advanced in the order of 15-30 m/s. Many flows were locally highly erosive. Field relations show that development of the fine grained ash cloud surge component was enhanced during the larger sustained events. Periods of elevated dome pyroclastic flow productivity and sustained collapse events are linked to pulses of high magma extrusion rates.

  9. Event Display for the Fixed Target Experiment BM@N

    NASA Astrophysics Data System (ADS)

    Gertsenberger, Konstantin

    2016-02-01

    One of the main problems to be solved in modern high energy physics experiments on particle collisions with a fixed target is the visual representation of the events during the experiment run. The article briefly describes the structure of the BM@N facility at the Nuclotron being under construction at the Joint Institute for Nuclear Research with the aim to study properties of the baryonic matter in collisions of ions with fixed target at energies up to 4 GeV/nucleon (for Au79+). Aspects concerning the visualization of data and detector details at the modern experiments and possibilities of practical applications are discussed. We present event display system intended to visualize the detector geometries and events of particle collisions with the fixed target, its options and features as well as integration with BMNRoot software. The examples of graphical representation of simulated and reconstructed points and particle tracks with BM@N geometry are given for central collisions of Au79+ ions with gold target and deuterons with carbon target.

  10. Recruiting Trends 1996-97. A National Study of Job Market Trends for New College Graduates among 508 Businesses, Industries, and Governmental Agencies. Twenty-Sixth Edition.

    ERIC Educational Resources Information Center

    Scheetz, L. Patrick

    This study examined recruiting trends of business, industry, and government among new college graduates. Questionnaires were mailed to 4,890 employers, of which 489 returned complete responses. The survey found that new college graduates of 1996-97 can expect growth in job opportunities. An increase of 6.2 percent in job prospects and an increase…

  11. Annual Survey of State Student Assessment Programs, Fall 1997. Volumes I and II. Data on 1996-97 Statewide Student Assessment Programs.

    ERIC Educational Resources Information Center

    Roeber, Edward; Bond, Linda; Connealy, Selena

    Volume 1 of the fall 1997 annual survey tabulates information about each state's assessment program during the 1996-97 school year. This volume contains the survey sent to state assessment directors, which was completed by representatives of all 50 states, and a summary table that lists the types of programs in each state. A list of state…

  12. Degree Completions in Areas of National Need, 1996-97 and 2001-02. E.D. Tab. NCES 2006-154

    ERIC Educational Resources Information Center

    Goan, Sarah Krichels; Cunningham, Alisa F.

    2006-01-01

    This E.D. Tab focuses on degree completions in academic programs that have been deemed areas of national need by federal legislation. The analysis focuses on completions data from 1996-97 and 2001-02 and examines completions at institutions granting awards of associate's degrees and higher. In particular, it looks at the change in the total number…

  13. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor),...

  14. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor),...

  15. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor),...

  16. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (firm target) contracts. 16.403-1 Section 16.403-1 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target) contract specifies a target cost, a target profit, a price ceiling (but not a profit ceiling or floor),...

  17. Salary-Trend Study of Faculty in Speech Pathology and Audiology for the Years 1996-97 and 1999-00.

    ERIC Educational Resources Information Center

    Howe, Richard D.

    This report is part of an annual national survey that examines salaries of full-time teaching faculty in 54 selected academic disciplines. Data for the study were collected from a total of 296 public and 390 private four-year institutions from the baseline year of 1996-97 to the trend year of 1999-2000. A data table lists average salaries for both…

  18. Salary-Trend Study of Faculty in Marketing Management and Research for the Years 1996-97 and 1999-00.

    ERIC Educational Resources Information Center

    Howe, Richard D.

    This report is part of an annual national survey that examines salaries of full-time teaching faculty in 54 selected academic disciplines. Data for the study were collected from a total of 296 public and 390 private four-year institutions from the baseline year of 1996-97 to the trend year of 1999-2000. This portion of the study covers salary data…

  19. The Super Fixed Target beauty facility at the SSC

    SciTech Connect

    Lau, Kwong; The SFT Collaboration

    1991-12-31

    The rationale for pursuing beauty physics at the SSC in a fixed target configuration is described. The increased beauty production cross section at the SSC, combined with high interaction rate capability of the proposed detector, results in 10{sup 10{minus}11} produced BB events per year. The long decay length of the B hadrons ({approx_equal} 10 cm) allows direct observation of B decays in the high resolution silicon microstrip vertex detector. To optimize the operation of the proposed beauty spectrometer and the SSC, parasitic extraction of attendant or artificially generated large amplitude protons using crystal channeling is proposed and explored. The large sample of fully reconstructed B events allows detailed studies of various CP violating decays with requisite statistics to confront the standard model. The CP physics potential of the proposed experiment is evaluated and compared with alternative approaches, such as symmetric e{sup +}e{sup {minus}} B Factories and specialized hadron colliders.

  20. Water-Level Changes, 1980 to 1997, and Saturated Thickness, 1996-97, In the High Plains Aquifer

    USGS Publications Warehouse

    McGuire, Virginia L.; Fischer, B.C.; Stanton, C.P.

    1999-01-01

    The High Plains aquifer underlies one of the major agricultural regions in the world, including parts of eight States--Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming. In the area underlain by the High Plains aquifer (called the High Plains region in this report), the total number of acres irrigated with ground water expanded rapidly after 1940: 1949--2.1 million acres; 1959--6.1 million acres; 1969--9.0 million acres; and 1980--13.7 million acres (Gutentag and others, 1984; Thelin and Heimes, 1987). In 1990, about 95 percent of the water withdrawn from the High Plains aquifer (about 15.7 million acre-feet) was used for irrigation (Marilee Horn, U.S.Geological Survey, written commun., 1996). Water-level declines appeared in the High Plains aquifer soon after extensive ground-water irrigation development began. By 1980, water levels in the High Plains aquifer in parts of Texas, Oklahoma, and southwestern Kansas had declined more than 100 feet (Luckey and others, 1981). In response to these declines, the U.S. Geological Survey, in cooperation with numerous Federal, State, and local water resource agencies, began a ground-water monitoring program in 1988 to assess annual water-level change in the aquifer using water-level measurements from more than 7,000 wells. The purpose of this report is to present (1) water-level changes in the High Plains aquifer from 1980 to 1997 and from 1996 to 1997, (2) the precipitation pattern in the High Plains region during 1996, and (3) estimated saturated thickness of the High Plains aquifer in 1996-97. The water-level measurements used in this report were collected in winter or early spring when irrigation wells were not pumping. Map scale and density of water-level elevation data preclude showing small areas in the maps of water-level change and saturated thickness where the value may be more or less than indicated.

  1. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price incentive... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive... parties have two alternatives, as follows: (i) They may negotiate a firm fixed price, using the...

  2. 48 CFR 16.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price incentive... Fixed-price incentive (firm target) contracts. (a) Description. A fixed-price incentive (firm target... positive, calculable profit incentive for the contractor to control costs. (b) Application. A...

  3. In celebration of the fixed target program with the Tevatron

    SciTech Connect

    Jeffrey A. Appel et al.

    2001-12-28

    The Tevatron is the world's first large superconducting accelerator. With its construction, we gained the dual opportunities to advance the state of the art in accelerator technology with the machine itself and in particle physics with the experiments that became possible in a higher energy regime. There have been 43 experiments in the Tevatron fixed target program. Many of these are better described as experimental programs, each with a broad range of physics goals and results, and more than 100 collaborating physicists and engineers. The results of this program are three-fold: (1) new technologies in accelerators, beams and detectors which advanced the state of the art; (2) new experimental results published in the refereed physics journals; and (3) newly trained scientists who are both the next generation of particle physicists and an important part of the scientific, technical and educational backbone of the country as a whole. In this book they compile these results. There are sections from each experiment including what their physics goals and results were, what papers were published, and which students have received degrees. Summaries of these results from the program as a whole are quite interesting, but the physics results from this program are too broad to summarize globally. The most important of the results appear in later sections of this booklet.

  4. 48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts....

  5. 48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts....

  6. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset:...

  7. 48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts....

  8. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset:...

  9. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset:...

  10. 48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts....

  11. 48 CFR 216.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (successive targets) contracts. 216.403-2 Section 216.403-2 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-2 Fixed-price incentive (successive targets) contracts. See PGI 216.403-2 for guidance on the use of fixed-price incentive (successive targets) contracts....

  12. 48 CFR 16.403-2 - Fixed-price incentive (successive targets) contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (successive targets) contracts. 16.403-2 Section 16.403-2 Federal Acquisition Regulations System FEDERAL... Fixed-price incentive (successive targets) contracts. (a) Description. (1) A fixed-price incentive (successive targets) contract specifies the following elements, all of which are negotiated at the outset:...

  13. Is there a role for fixed target heavy ion physics beyond RHIC startup?

    SciTech Connect

    Sandweiss, J.

    1995-07-15

    The interesting and important physics opportunities provided by AGS and CERN fixed target facilities will be far from exhausted by the time of RHIC turn on. Given the need for the AGS to provide heavy ion beams for injection into RHIC, the cost effectiveness of fixed target experimentation with AGS beams will be high. Examples of the physics are given.

  14. Main Ring bunch spreaders: Past, 1987/1988 fixed target run, and proposed future

    SciTech Connect

    Jackson, G.P.

    1989-02-26

    During the last 1987--1988 fixed target running period beam intensity was limited many times by coherent instabilities in both the Main Ring and in the Tevatron. The intensity thresholds for instabilities are generally inversely proportional to the proton bunch length. Since fixed target operations are insensitive to the longitudinal phase space emittance of the beam, bunch spreaders are employed to increase this emittance, and hence the bunch length. As a result, more beam intensity can be delivered to the fixed target experiments. This paper starts with a short history behind the old Main Ring bunch spreader. After discussing the physics of stimulated emittance growth, the design and performance of the 1987--1988 fixed target run Main Ring bunch spreader is discussed. Finally, designs of improved Main Ring and Tevatron bunch spreaders for the next fixed target run are proposed. 23 figs.

  15. Renaissance of the {approximately} 1-TeV fixed-target program.

    SciTech Connect

    Adams, T.; Appel, J. A.; Arms, K. E.; Balantekin, A. B.; Conrad, J. M.; Tait, T. M. P.; High Energy Physics; Amherst Coll.; Univ. of Wisconsin at Madison; Massachuetts Inst. of Tech.

    2010-01-01

    This document describes the physics potential of a new fixed-target program based on a {approx}1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  16. Renaissance of the ~1 TeV Fixed-Target Program

    NASA Astrophysics Data System (ADS)

    Adams, T.; Appel, J. A.; Arms, K. E.; Balantekin, A. B.; Conrad, J. M.; Cooper, P. S.; Djurcic, Z.; Dunwoodie, W.; Engelfried, J.; Fisher, P. H.; Gottschalk, E.; de Gouvea, A.; Heller, K.; Ignarra, C. M.; Karagiorgi, G.; Kwan, S.; Loinaz, W. A.; Meadows, B.; Moore, R.; Morfín, J. G.; Naples, D.; Nienaber, P.; Pate, S. F.; Papavassiliou, V.; Petrov, A. A.; Purohit, M. V.; Ray, H.; Russ, J.; Schwartz, A. J.; Seligman, W. G.; Shaevitz, M. H.; Schellman, H.; Spitz, J.; Syphers, M. J.; Tait, T. M. P.; Vannucci, F.

    This document describes the physics potential of a new fixed-target program based on a ~1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  17. Renaissance of the ~ 1-TeV Fixed-Target Program

    SciTech Connect

    Adams, T.; Appel, J.A.; Arms, K.E.; Balantekin, A.B.; Conrad, J.M.; Cooper, P.S.; Djurcic, Z.; Dunwoodie, W.; Engelfried, J.; Fisher, P.H.; Gottschalk, Erik Edward; de Gouvea, A.; Heller, K.; Ignarra, C.M.; Karagiorgi, G.; Kwan, S.; Loinaz, W.A.; Meadows, B.; Moore, R.; Morfin, J.G.; Naples, D.; /Pittsburgh U. /St. Mary's Coll., Minnesota /New Mexico State U. /Michigan U. /Wayne State U. /South Carolina U. /Florida U. /Carnegie Mellon U. /Cincinnati U. /Columbia U. /Columbia U. /Northwestern U. /Yale U. /Fermilab /Argonne /Northwestern U. /APC, Paris

    2011-12-02

    This document describes the physics potential of a new fixed-target program based on a {approx}1 TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  18. Renaissance of the ~1 TeV Fixed-Target Program

    SciTech Connect

    Adams, T.; Appel, Jeffrey A.; Arms, Kregg Elliott; Balantekin, A.B.; Conrad, Janet Marie; Cooper, Peter S.; Djurcic, Zelimir; Dunwoodie, William M.; Engelfried, Jurgen; Fisher, Peter H.; Gottschalk, E.; /Fermilab /Northwestern U.

    2009-05-01

    This document describes the physics potential of a new fixed-target program based on a {approx} TeV proton source. Two proton sources are potentially available in the future: the existing Tevatron at Fermilab, which can provide 800 GeV protons for fixed-target physics, and a possible upgrade to the SPS at CERN, called SPS+, which would produce 1 TeV protons on target. In this paper we use an example Tevatron fixed-target program to illustrate the high discovery potential possible in the charm and neutrino sectors. We highlight examples which are either unique to the program or difficult to accomplish at other venues.

  19. 48 CFR 216.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (firm target) contracts. 216.403-1 Section 216.403-1 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-1 Fixed-price incentive (firm target) contracts. (b) Application. (1... target) contracts, especially for acquisitions moving from development to production. (2) The...

  20. 48 CFR 216.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (firm target) contracts. 216.403-1 Section 216.403-1 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-1 Fixed-price incentive (firm target) contracts. (b) Application. (1... target) contracts, especially for acquisitions moving from development to production. (2) The...

  1. 48 CFR 216.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (firm target) contracts. 216.403-1 Section 216.403-1 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-1 Fixed-price incentive (firm target) contracts. (b) Application. (1... target) contracts, especially for acquisitions moving from development to production. (2) The...

  2. 48 CFR 216.403-1 - Fixed-price incentive (firm target) contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (firm target) contracts. 216.403-1 Section 216.403-1 Federal Acquisition Regulations System DEFENSE... CONTRACTS Incentive Contracts 216.403-1 Fixed-price incentive (firm target) contracts. (b) Application. (1... target) contracts, especially for acquisitions moving from development to production. (2) The...

  3. Fixed lag smoothing target tracking in clutter for a high pulse repetition frequency radar

    NASA Astrophysics Data System (ADS)

    Khan, Uzair; Shi, Yi Fang; Song, Taek Lyul

    2015-12-01

    A new method to smooth the target hybrid state with Gaussian mixture measurement likelihood-integrated track splitting (GMM-ITS) in the presence of clutter for a high pulse repetition frequency (HPRF) radar is proposed. This method smooths the target state at fixed lag N and considers all feasible multi-scan target existence sequences in the temporal window of scans in order to smooth the target hybrid state. The smoothing window can be of any length N. The proposed method to smooth the target hybrid state at fixed lag is also applied to the enhanced multiple model (EMM) tracking algorithm. Simulation results indicate that the performance of fixed lag smoothing GMM-ITS significantly improves false track discrimination and root mean square errors (RMSEs).

  4. Salary-Trend Studies for the Years 1993-94 and 1996-97 in the Following 27 Academic Disciplines/Major Fields: Accounting, Administrative Assistant/Secretarial Science, General;...Geology.

    ERIC Educational Resources Information Center

    Howe, Richard D.

    This document provides comparative salary trend data for full-time faculty at 307 public institutions and 490 private colleges and universities based on two surveys, one for the baseline year 1993-94 and the other for the trend year 1996-97. For each of the 27 disciplines, a summary includes a definition of the discipline; information on average…

  5. Salary-Trend Studies of Faculty for the Years 1993-94 and 1996-97 in the Following 26 Academic Disciplines/Major Fields: History, General;...Visual and Performing Arts.

    ERIC Educational Resources Information Center

    Howe, Richard D.

    This document provides comparative salary trend data for full-time faculty at 307 public institutions and 490 private colleges and universities based on two surveys, one for the baseline year 1993-94 and the other for the trend year 1996-97. For each of the 26 disciplines, a summary includes a definition of the discipline; information on average…

  6. AAHE Bulletin, 1996-97.

    ERIC Educational Resources Information Center

    Marchese, Theodore J., Ed.

    1997-01-01

    The 10 issues of this bulletin present reports, reviews and essays on issues concerning the advancement of higher education. Major articles include: "Learning, Teaching Technology"--an interview with Diana Laurillard of Britain's Open University; "Learning, Technology, and the Way We Work" (Russ Edgerton and Barbara Leigh Smith); "Implementing the…

  7. New Fixed-Target Experiments to Search for Dark Gauge Forces

    SciTech Connect

    Bjorken, James D.; Essig, Rouven; Schuster, Philip; Toro, Natalia; /Stanford U., ITP

    2010-06-11

    Fixed-target experiments are ideally suited for discovering new MeV-GeV mass U(1) gauge bosons through their kinetic mixing with the photon. In this paper, we identify the production and decay properties of new light gauge bosons that dictate fixed-target search strategies. We summarize existing limits and suggest five new experimental approaches that we anticipate can cover most of the natural parameter space, using currently operating GeV-energy beams and well-established detection methods. Such experiments are particularly timely in light of recent terrestrial and astrophysical anomalies (PAMELA, FERMI, DAMA/LIBRA, etc.) consistent with dark matter charged under a new gauge force.

  8. Overview of results from the Fermilab fixed target and collider experiments

    SciTech Connect

    Montgomery, H.E.

    1997-06-01

    In this paper we present a review of recent QCD related results from Fermilab fixed target and collider experiments. Topics covered range from structure functions through W/Z production, heavy quark production and jet angular distributions. We also include the current state of knowledge about leptoquark pair production in hadronic collisions.

  9. The fixed target experiment for studies of baryonic matter at the Nuclotron (BM@N)

    NASA Astrophysics Data System (ADS)

    Kapishin, Mikhail

    2016-08-01

    BM@N (Baryonic Matter at Nuclotron) is the first experiment to be realized at the accelerator complex of NICA-Nuclotron. The aim of the BM@N experiment is to study interactions of relativistic heavy-ion beams with fixed targets. The BM@N setup, results of Monte Carlo simulations and the BM@N experimental program are presented.

  10. Head perturbations during walking while viewing a head-fixed target

    NASA Technical Reports Server (NTRS)

    Das, Vallabh E.; Zivotofsky, Ari Z.; Discenna, Alfred O.; Leigh, R. John

    1995-01-01

    Inexpensive, head-fixed computer displays are now available that subjects can wear during locomotion. Our hypothesis is that viewing a head-fixed visual display will change the character- istics of rotational head perturbations during natural walking. Using a 3-axis angular rate sensor, we measured head rotations during natural or treadmill walking, in 10 normal subjects and 2 patients with deficient vestibular function, as they attempted to view (1) a stationary target at optical infinity; and (2) a target at a distance of 20 cm rigidly attached to the head. Normal subjects and patients showed no significant change in the predominant frequency of head rotations in any plane (ranging 0.7-5.7 Hz) during the two different viewing tasks. Mean peak head velocities also showed no difference during the two viewing conditions except in the yaw plane, in which values were greater while viewing the near target. Predominant frequencies of head rotations were similar in the pitch plane during natural or treadmill walking; however, peak velocities of pitch head rotations were substantially greater during natural walking. One vestibular patient showed modest increases of head velocity during natural walking compared with normal subjects. Rotational head perturbations that occur during natural walking are largely unaffected when subjects view a head-fixed target. There is need to study how such perturbations, which induce vestibular eye movements, affect vision of head-fixed displays.

  11. Moving target detection through omni-orientational vision fixed on AGV

    NASA Astrophysics Data System (ADS)

    Yang, Shu-Ying; Cao, Zuo-Liang; He, Pei-Lian

    2006-10-01

    Extremely wide view of the omni-vision performs highly advanced for the vehicle navigation and target detection. However moving targets detection through omni-vision fixed on AGV (Automatic Guided Vehicle) involves more complex environments, where both the targets and the vehicle are in the moving condition. The moving targets will be detected in a moving background. After analyzing the character on omniorientational vision and image, we propose to use the estimation in optical flow fields, Gabor filter over optical flow fields for detecting moving objects. Because polar angle θ and polar radius R of polar coordinates are being changed as the targets moving, we improved optical flow approach which can be calculated based on the polar coordinates at the omniorientational center. We constructed Gabor filter which has 24 orientations every 15°, and filter optical flow fields at 24 orientations. By the contrast of the Gabor filter images at the same orientation and the same AGV position between the situation which there aren't any moving targets in the environment and the situation which there are some moving targets in the same environment, the moving targets' optical flow fields could be recognized. Experiment results show that the proposed approach is feasible and effective.

  12. Mountain Island Lake, North Carolina; analysis of ambient conditions and simulation of hydrodynamics, constituent transport, and water-quality characteristics, 1996-97

    USGS Publications Warehouse

    Bales, Jerad D.; Sarver, Kathleen M.; Giorgino, Mary J.

    2001-01-01

    Mountain Island Lake is an impoundment of the Catawba River in North Carolina and supplies drinking water to more than 600,000 people in Charlotte, Gastonia, Mount Holly, and several other communities. The U.S. Geological Survey, in cooperation with the Charlotte-Mecklenburg Utilities, conducted an investigation of the reservoir to characterize hydrologic and water-quality conditions and to develop and apply a simulation model to predict the response of the reservoir to changes in constituent loadings or the flow regime. During 1996-97, flows into Mountain Island Lake were dominated by releases from Cowans Ford Dam on Lake Norman, with more than 85 percent of the total inflow to the reservoir coming from Lake Norman. Riverbend Steam Station discharges accounted for about 12 percent of the inflows to the reservoir, and inflows from tributary streams contributed less than 1.5 percent of the total inflows. Releases through Mountain Island Dam accounted for about 81 percent of outflows from the reservoir, while Riverbend Steam Station withdrawals, which were equal to discharge from the facility, constituted about 13 percent of the reservoir withdrawals. About 5.5 percent of the withdrawals from the reservoir were for water supply. Strong thermal stratification was seldom observed in Mountain Island Lake during April 1996-September 1997. As a result, dissolved-oxygen concentrations were only infrequently less than 4 milligrams per liter, and seldom less than 5 milligrams per liter throughout the entire reservoir, including the coves. The Riverbend Steam Station thermal discharge had a pronounced effect on surface-water temperatures near the outfall. McDowell Creek, which drains to McDowell Creek cove, receives treated wastewater from a large municipal facility and has exhibited signs of poor water-quality conditions in the past. During April 1996-September 1997, concentrations of nitrate, ammonia, total phosphorus, and chlorophyll a were higher in McDowell Creek cove

  13. Automating ground-fixed target modeling with the smart target model generator

    NASA Astrophysics Data System (ADS)

    Verner, D.; Dukes, R.

    2007-04-01

    The Smart Target Model Generator (STMG) is an AFRL/MNAL sponsored tool for generating 3D building models for use in various weapon effectiveness tools. These tools include tri-service approved tools such as Modular Effectiveness/Vulnerability Assessment (MEVA), Building Analysis Module in Joint Weaponeering System (JWS), PENCRV3D, and WinBlast. It also supports internal dispersion modeling of chemical contaminants. STMG also has capabilities to generate infrared or other sensor images. Unlike most CAD-models, STMG provides physics-based component properties such as strength, density, reinforcement, and material type. Interior components such as electrical and mechanical equipment, rooms, and ducts are also modeled. Buildings can be manually created with a graphical editor or automatically generated using rule-bases which size and place the structural components using rules based on structural engineering principles. In addition to its primary purposes of supporting conventional kinetic munitions, it can also be used to support sensor modeling and automatic target recognition.

  14. High Transverse Momentum Direct Photon Production at Fermilab Fixed-Target Energies

    SciTech Connect

    Apanasevich, Leonard

    2005-01-01

    This thesis describes a study of the production of high transverse momentum direct photons and π0 mesons by proton beams at 530 and 800 GeV/c and π- beams at 515 GeV/c incident on beryllium, copper, and liquid hydrogen targets. The data were collected by Fermilab experiment E706 during the 1990 and 1991-92 fixed target runs. The apparatus included a large, finely segmented lead and liquid argon electromagnetic calorimeter and a charged particle spectrometer featuring silicon strip detectors in the target region and proportional wire chambers and drift tubes downstream of a large aperture analysis magnet. The inclusive cross sections are presented as functions of transverse momentum and rapidity. The measurements are compared with next-to-leading order perturbative QCD calculations and to results from previous experiments.

  15. Preparation of a primary argon beam for the CERN fixed target physics

    SciTech Connect

    Küchler, D. O’Neil, M.; Scrivens, R.; Thomae, R.

    2014-02-15

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar{sup 11+} beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  16. Preparation of a primary argon beam for the CERN fixed target physics.

    PubMed

    Küchler, D; O'Neil, M; Scrivens, R; Thomae, R

    2014-02-01

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar(11+) beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  17. J/{sub psi} production: Tevatron and fixed-target collisions

    SciTech Connect

    Petrelli, A.

    2000-06-01

    In this talk the author shows the results of a fit of the NRQCD matrix elements to the CDF data for direct J/{psi} production, by including the radiative corrections to the g g {r_arrow} {sup 3} S {sub 1}{sup [1]} channel and the effect of the k{sub T}-smearing. Furthermore he performs the NLO NRQCD analysis of J/{psi} production in fixed-target proton-nucleon collisions and he fits the colour-octet matrix elements to the available experimental data. The results are compared to the Tevatron ones.

  18. Estimation of Cn² based on scintillation of fixed targets imaged through atmospheric turbulence.

    PubMed

    Gulich, Damián; Funes, Gustavo; Pérez, Darío; Zunino, Luciano

    2015-12-01

    We define a pixel-based scintillation index for dynamic incoherent imaging of fixed high-contrast targets through atmospheric turbulence. We propose a simple setup to study this parameter varying the Cn(2) constant in controlled laboratory conditions (weak fluctuation regime). We find the semi-empirical relationship between the pixel-based scintillation index and the index of refraction structure constant, which we then employ to estimate Cn(2) successfully in an independent case in which this value was not known beforehand.

  19. Preparation of a primary argon beam for the CERN fixed target physics

    NASA Astrophysics Data System (ADS)

    Küchler, D.; O'Neil, M.; Scrivens, R.; Thomae, R.

    2014-02-01

    The fixed target experiment NA61 in the North Area of the Super Proton Synchrotron is studying phase transitions in strongly interacting matter. Up to now they used the primary beams available from the CERN accelerator complex (protons and lead ions) or fragmented beams created from the primary lead ion beam. To explore a wider range of energies and densities a request was made to provide primary argon and xenon beams. This paper describes the results of the setting up and 10 week test run of the Ar11+ beam from the 14.5 GHz ECR ion source and the linear accelerator (Linac3) at CERN.

  20. Physics Opportunities of a Fixed-Target Experiment using the LHC Beams

    SciTech Connect

    Brodsky, S.J.; Fleuret, F.; Hadjidakis, C.; Lansberg, J.P.; /Orsay, IPN

    2012-03-16

    We outline the many physics opportunities offered by a multi-purpose fixed-target experiment using the proton and lead-ion beams of the LHC extracted by a bent crystal. In a proton run with the LHC 7-TeV beam, one can analyze pp, pd and pA collisions at center-of-mass energy {radical}s{sub NN} {approx_equal} 115 GeV and even higher using the Fermi motion of the nucleons in a nuclear target. In a lead run with a 2.76 TeV-per-nucleon beam, {radical}s{sub NN} is as high as 72 GeV. Bent crystals can be used to extract about 5 x 10{sup 8} protons/sec; the integrated luminosity over a year reaches 0.5 fb{sup -1} on a typical 1 cm-long target without nuclear species limitation. We emphasize that such an extraction mode does not alter the performance of the collider experiments at the LHC. By instrumenting the target-rapidity region, gluon and heavy-quark distributions of the proton and the neutron can be accessed at large x and even at x larger than unity in the nuclear case. Single diffractive physics and, for the first time, the large negative-xF domain can be accessed. The nuclear target-species versatility provides a unique opportunity to study nuclear matter versus the features of the hot and dense matter formed in heavy-ion collisions, including the formation of the quark-gluon plasma, which can be studied in PbA collisions over the full range of target-rapidity domain with a large variety of nuclei. The polarization of hydrogen and nuclear targets allows an ambitious spin program, including measurements of the QCD lensing effects which underlie the Sivers single-spin asymmetry, the study of transversity distributions and possibly of polarized parton distributions. We also emphasize the potential offered by pA ultra-peripheral collisions where the nucleus target A is used as a coherent photon source, mimicking photoproduction processes in ep collisions. Finally, we note that W and Z bosons can be produced and detected in a fixed-target experiment and in their

  1. Physics opportunities of a fixed-target experiment using LHC beams

    NASA Astrophysics Data System (ADS)

    Brodsky, S. J.; Fleuret, F.; Hadjidakis, C.; Lansberg, J. P.

    2013-01-01

    We outline the many physics opportunities offered by a multi-purpose fixed-target experiment using the proton and lead-ion beams of the LHC extracted by a bent crystal. In a proton run with the LHC 7 TeV beam, one can analyze pp, pd and pA collisions at center-of-mass energy √{s}≃115 GeV and even higher using the Fermi motion of the nucleons in a nuclear target. In a lead run with a 2.76 TeV-per-nucleon beam, √{s} is as high as 72 GeV. Bent crystals can be used to extract about 5×108 protons/s; the integrated luminosity over a year reaches 0.5 fb-1 on a typical 1 cm long target without nuclear species limitation. We emphasize that such an extraction mode does not alter the performance of the collider experiments at the LHC. By instrumenting the target-rapidity region, gluon and heavy-quark distributions of the proton and the neutron can be accessed at large x and even at x larger than unity in the nuclear case. Single diffractive physics and, for the first time, the large negative-xF domain can be accessed. The nuclear target-species versatility provides a unique opportunity to study nuclear matter versus the features of the hot and dense matter formed in heavy-ion collisions, including the formation of the quark-gluon plasma, which can be studied in PbA collisions over the full range of target-rapidity domain with a large variety of nuclei. The polarization of hydrogen and nuclear targets allows an ambitious spin program, including measurements of the QCD lensing effects which underlie the Sivers single-spin asymmetry, the study of transversity distributions and possibly of polarized parton distributions. We also emphasize the potential offered by pA ultra-peripheral collisions where the nucleus target A is used as a coherent photon source, mimicking photoproduction processes in ep collisions. Finally, we note that W and Z bosons can be produced and detected in a fixed-target experiment and in their threshold domain for the first time, providing new ways to

  2. Surface target-tracking guidance by self-organizing formation flight of fixed-wing UAV

    NASA Astrophysics Data System (ADS)

    Regina, N.; Zanzi, M.

    This paper presents a new concept of ground target surveillance based on a formation flight of two Unmanned Aerial Vehicles (UAVs) of fixed-wing type. Each UAV considered in this work has its own guidance law specifically designed for two different aims. A self organizing non-symmetric collaborative surveying scheme has been developed based on pursuers with different roles: the close-up-pursuer and the distance-pursuer. The close-up-pursuer behaves according to a guidance law which takes it to continually over-fly the target, also optimizing flight endurance. On the other hand, the distancepursuer behaves so as to circle around the target by flying at a certain distance and altitude from it; moreover, its motion ensures the maximum “ seeability” of the ground based target. In addition, the guidance law designed for the distance-pursuer also implements a collision avoidance feature in order to prevent possible risks of collision with the close-up-pursuer during the tracking maneuvers. The surveying scheme is non-symmetric in the sense that the collision avoidance feature is accomplished by a guidance law implemented only on one of the two pursuers; moreover, it is collaborative because the surveying is performed by different tasks of two UAVs and is self-organizing because, due to the collision avoidance feature, target tracking does not require pre-planned collision-risk-free trajectories but trajectories are generated in real time.

  3. Protein characterization of intracellular target-sorted, formalin-fixed cell subpopulations

    PubMed Central

    Sadick, Jessica S.; Boutin, Molly E.; Hoffman-Kim, Diane; Darling, Eric M.

    2016-01-01

    Cellular heterogeneity is inherent in most human tissues, making the investigation of specific cell types challenging. Here, we describe a novel, fixation/intracellular target-based sorting and protein extraction method to provide accurate protein characterization for cell subpopulations. Validation and feasibility tests were conducted using homogeneous, neural cell lines and heterogeneous, rat brain cells, respectively. Intracellular proteins of interest were labeled with fluorescent antibodies for fluorescence-activated cell sorting. Reproducible protein extraction from fresh and fixed samples required lysis buffer with high concentrations of Tris-HCl and sodium dodecyl sulfate as well as exposure to high heat. No deterioration in protein amount or quality was observed for fixed, sorted samples. For the feasibility experiment, a primary rat subpopulation of neuronal cells was selected for based on high, intracellular β-III tubulin signal. These cells showed distinct protein expression differences from the unsorted population for specific (phosphorylated tau) and non-specific (total tau) protein targets. Our approach allows for determining more accurate protein profiles directly from cell types of interest and provides a platform technology in which any cell subpopulation can be biochemically investigated. PMID:27666089

  4. Quarkonium Physics at a Fixed-Target Experiment Using the LHC Beams

    SciTech Connect

    Lansberg, J.P.; Brodsky, S.J.; Fleuret, F.; Hadjidakis, C.; /Orsay, IPN

    2012-04-09

    We outline the many quarkonium-physics opportunities offered by a multi-purpose fixed-target experiment using the p and Pb LHC beams extracted by a bent crystal. This provides an integrated luminosity of 0.5 fb{sup -1} per year on a typical 1cm-long target. Such an extraction mode does not alter the performance of the collider experiments at the LHC. With such a high luminosity, one can analyse quarkonium production in great details in pp, pd and pA collisions at {radical}s{sub NN} {approx_equal} 115 GeV and at {radical}s{sub NN} {approx_equal} 72 GeV in PbA collisions. In a typical pp (pA) run, the obtained quarkonium yields per unit of rapidity are 2-3 orders of magnitude larger than those expected at RHIC and about respectively 10 (70) times larger than for ALICE. In PbA, they are comparable. By instrumenting the target-rapidity region, the large negative-x{sub F} domain can be accessed for the first time, greatly extending previous measurements by Hera-B and E866. Such analyses should help resolving the quarkonium-production controversies and clear the way for gluon PDF extraction via quarkonium studies. The nuclear target-species versatility provides a unique opportunity to study nuclear matter and the features of the hot and dense matter formed in PbA collisions. A polarised proton target allows the study of transverse-spin asymmetries in J/{Psi} and {Upsilon} production, providing access to the gluon and charm Sivers functions.

  5. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics

    PubMed Central

    Zhao, Yue; Cottrell, Joseph; Klotzle, Brandy; Godwin, Andrew K.; Koestler, Devin; Beyerlein, Peter; Fan, Jian-Bing; Bibikova, Marina; Chien, Jeremy

    2015-01-01

    Current genomic studies are limited by the poor availability of fresh-frozen tissue samples. Although formalin-fixed diagnostic samples are in abundance, they are seldom used in current genomic studies because of the concern of formalin-fixation artifacts. Better characterization of these artifacts will allow the use of archived clinical specimens in translational and clinical research studies. To provide a systematic analysis of formalin-fixation artifacts on Illumina sequencing, we generated 26 DNA sequencing data sets from 13 pairs of matched formalin-fixed paraffin-embedded (FFPE) and fresh-frozen (FF) tissue samples. The results indicate high rate of concordant calls between matched FF/FFPE pairs at reference and variant positions in three commonly used sequencing approaches (whole genome, whole exome, and targeted exon sequencing). Global mismatch rates and C·G > T·A substitutions were comparable between matched FF/FFPE samples, and discordant rates were low (<0.26%) in all samples. Finally, low-pass whole genome sequencing produces similar pattern of copy number alterations between FF/FFPE pairs. The results from our studies suggest the potential use of diagnostic FFPE samples for cancer genomic studies to characterize and catalog variations in cancer genomes. PMID:26305677

  6. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics.

    PubMed

    Munchel, Sarah; Hoang, Yen; Zhao, Yue; Cottrell, Joseph; Klotzle, Brandy; Godwin, Andrew K; Koestler, Devin; Beyerlein, Peter; Fan, Jian-Bing; Bibikova, Marina; Chien, Jeremy

    2015-09-22

    Current genomic studies are limited by the poor availability of fresh-frozen tissue samples. Although formalin-fixed diagnostic samples are in abundance, they are seldom used in current genomic studies because of the concern of formalin-fixation artifacts. Better characterization of these artifacts will allow the use of archived clinical specimens in translational and clinical research studies. To provide a systematic analysis of formalin-fixation artifacts on Illumina sequencing, we generated 26 DNA sequencing data sets from 13 pairs of matched formalin-fixed paraffin-embedded (FFPE) and fresh-frozen (FF) tissue samples. The results indicate high rate of concordant calls between matched FF/FFPE pairs at reference and variant positions in three commonly used sequencing approaches (whole genome, whole exome, and targeted exon sequencing). Global mismatch rates and C · G > T · A substitutions were comparable between matched FF/FFPE samples, and discordant rates were low (<0.26%) in all samples. Finally, low-pass whole genome sequencing produces similar pattern of copy number alterations between FF/FFPE pairs. The results from our studies suggest the potential use of diagnostic FFPE samples for cancer genomic studies to characterize and catalog variations in cancer genomes.

  7. Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics.

    PubMed

    Munchel, Sarah; Hoang, Yen; Zhao, Yue; Cottrell, Joseph; Klotzle, Brandy; Godwin, Andrew K; Koestler, Devin; Beyerlein, Peter; Fan, Jian-Bing; Bibikova, Marina; Chien, Jeremy

    2015-09-22

    Current genomic studies are limited by the poor availability of fresh-frozen tissue samples. Although formalin-fixed diagnostic samples are in abundance, they are seldom used in current genomic studies because of the concern of formalin-fixation artifacts. Better characterization of these artifacts will allow the use of archived clinical specimens in translational and clinical research studies. To provide a systematic analysis of formalin-fixation artifacts on Illumina sequencing, we generated 26 DNA sequencing data sets from 13 pairs of matched formalin-fixed paraffin-embedded (FFPE) and fresh-frozen (FF) tissue samples. The results indicate high rate of concordant calls between matched FF/FFPE pairs at reference and variant positions in three commonly used sequencing approaches (whole genome, whole exome, and targeted exon sequencing). Global mismatch rates and C · G > T · A substitutions were comparable between matched FF/FFPE samples, and discordant rates were low (<0.26%) in all samples. Finally, low-pass whole genome sequencing produces similar pattern of copy number alterations between FF/FFPE pairs. The results from our studies suggest the potential use of diagnostic FFPE samples for cancer genomic studies to characterize and catalog variations in cancer genomes. PMID:26305677

  8. The unified database for the fixed target experiment BM@N

    NASA Astrophysics Data System (ADS)

    Gertsenberger, K. V.

    2016-09-01

    The article describes the developed database designed as comprehensive data storage of the fixed target experiment BM@N [1] at Joint Institute for Nuclear Research (JINR) in Dubna. The structure and purposes of the BM@N facility will be briefly presented. The scheme of the unified database and its parameters will be described in detail. The use of the BM@N database implemented on the PostgreSQL database management system (DBMS) allows one to provide user access to the actual information of the experiment. Also the interfaces developed for the access to the database will be presented. One was implemented as the set of C++ classes to access the data without SQL statements, the other-Web-interface being available on the Web page of the BM@N experiment.

  9. Measurement of strange particle production in the NICA fixed-target programme

    NASA Astrophysics Data System (ADS)

    Friese, Volker

    2016-08-01

    Strange particles provide a sensitive tool to study the dense and hot matter created in relativistic nuclear collisions. Although strangeness production in such collisions has been a topic of experimental and theoretical research for many years, its understanding is far from being complete. This holds in particular for multi-strange hyperons and for lower collision energies as relevant for NICA and FAIR. Multi-strange particles, being sensitive to both the mechanism of strangeness production and the net-baryon density, are expected to shed light on the state of the created matter and to indicate possible transitions to new phases of strongly interacting matter. We thus advocate the measurement of hyperons and φ mesons in a fixed-target experiment at NICA (BM@N), which can be achieved by a relatively compact detector system.

  10. Low-Z polymer sample supports for fixed-target serial femtosecond X-ray crystallography

    SciTech Connect

    Feld, Geoffrey K.; Heymann, Michael; Benner, W. Henry; Pardini, Tommaso; Tsai, Ching -Ju; Boutet, Sebastien; Coleman, Matthew A.; Hunter, Mark S.; Li, Xiaodan; Messerschmidt, Marc; Opathalage, Achini; Pedrini, Bill; Williams, Garth J.; Krantz, Bryan A.; Fraden, Seth; Hau-Riege, Stefan; Evans, James E.; Segelke, Brent W.; Frank, Matthias

    2015-06-27

    X-ray free-electron lasers (XFELs) offer a new avenue to the structural probing of complex materials, including biomolecules. Delivery of precious sample to the XFEL beam is a key consideration, as the sample of interest must be serially replaced after each destructive pulse. The fixed-target approach to sample delivery involves depositing samples on a thin-film support and subsequent serial introduction via a translating stage. Some classes of biological materials, including two-dimensional protein crystals, must be introduced on fixed-target supports, as they require a flat surface to prevent sample wrinkling. A series of wafer and transmission electron microscopy (TEM)-style grid supports constructed of low-Z plastic have been custom-designed and produced. Aluminium TEM grid holders were engineered, capable of delivering up to 20 different conventional or plastic TEM grids using fixed-target stages available at the Linac Coherent Light Source (LCLS). As proof-of-principle, X-ray diffraction has been demonstrated from two-dimensional crystals of bacteriorhodopsin and three-dimensional crystals of anthrax toxin protective antigen mounted on these supports at the LCLS. In conclusion, the benefits and limitations of these low-Z fixed-target supports are discussed; it is the authors' belief that they represent a viable and efficient alternative to previously reported fixed-target supports for conducting diffraction studies with XFELs.

  11. Proposed Fermilab fixed target experiment: Kaons at the Tevatron. Environmental Assessment

    SciTech Connect

    Not Available

    1993-12-01

    The US Department of Energy (DOE) has prepared an Environmental Assessment (EA), DOE/EA-0898, evaluating the impacts associated with the proposed fixed target experiment at the Fermi National Accelerator Laboratory (Femilab) in Batavia, Illinois, known as Kaons at the Tevatron (KTeV). The proposed KTeV project includes reconfiguration of an existing target station, enhancement of an existing beam transport system connected to existing utility facilities, and construction of a new experimental detector hall area. The study of the K meson, a type of subatomic particle, has been going on at Fermilab for 20 years. The proposed KTEV project advances the search for the origins of a violation of a fundamental symmetry of nature called charge parity (CP) violation. Based on the analysis in the EA, the DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement is not required.

  12. Evaluation of water-level recovery, 1996-97 to 1999-2000, and comparison of 1999-2000 and 1972-73 water levels in Goleta Central Subbasin, Santa Barbara County, California

    USGS Publications Warehouse

    Densmore, Jill N.; Scrudato, Matthew C.; Houston, Ernest R.

    2001-01-01

    Ground-water levels were measured during January 1999-June 2000 to evaluate the rate of water-level recovery in the Goleta Central ground-water subbasin that has resulted from injection of about 2,225 acre-feet of surplus water for storage in the ground-water basin. Injection of surplus water was tabulated and compared with water-level rises since 1996 to evaluate the effectiveness of the recharge effort. Water levels have risen about 4 to 37 feet since 1996-97. A preliminary water budget was compiled to assess recharge and discharge in the basin, and it is estimated that total inflow exceeded total outflow during 1998-99 by about 2,844 to 7,518 acre-feet. In addition, water levels for 1999-2000 were compared with water levels for 1972-73 to determine if a 'drought buffer' exists. Water levels measured in two wells during January 1999-June 2000 exceeded January 1972-June 1973 levels. Water levels in the remaining wells measured during January 1999-June 2000 ranged from less than 1 foot to about 32 feet below 1972-73 water levels. In general, the largest water-level rise between 1996-97 and 1999-2000 was about 37 feet in the southeastern end of the basin; the rise was less than 4 feet in the western end of the basin and about 10 feet north of the Goleta Fault. Long-term hydrographs indicate that water levels have been recovering throughout the basin since the early 1990's.

  13. Report of the super fixed target beauty facility working group on progress towards the SFT at the SSC

    SciTech Connect

    Brown, H.; Cumalat, J.; Carrigan, R.A.

    1992-12-31

    A low intensity 20 TeV proton beam extracted from the SSC by crystal channeling has been proposed for use in producing B hadrons in a fixed target configuration. This option for doing B physics offers a relatively inexpensive way of obtaining large numbers of reconstructable B decays for the study of rare B decays and CP violation in the B system. This paper reports on the progress during and since the 1990 Snowmass meeting in developing the techniques for the crystal extraction and discusses special advantages that an SSC fixed target spectrometer may have relative to other experimental methods for studying B decays.

  14. Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography.

    PubMed

    Oghbaey, Saeed; Sarracini, Antoine; Ginn, Helen M; Pare-Labrosse, Olivier; Kuo, Anling; Marx, Alexander; Epp, Sascha W; Sherrell, Darren A; Eger, Bryan T; Zhong, Yinpeng; Loch, Rolf; Mariani, Valerio; Alonso-Mori, Roberto; Nelson, Silke; Lemke, Henrik T; Owen, Robin L; Pearson, Arwen R; Stuart, David I; Ernst, Oliver P; Mueller-Werkmeister, Henrike M; Miller, R J Dwayne

    2016-08-01

    The advent of ultrafast highly brilliant coherent X-ray free-electron laser sources has driven the development of novel structure-determination approaches for proteins, and promises visualization of protein dynamics on sub-picosecond timescales with full atomic resolution. Significant efforts are being applied to the development of sample-delivery systems that allow these unique sources to be most efficiently exploited for high-throughput serial femtosecond crystallography. Here, the next iteration of a fixed-target crystallography chip designed for rapid and reliable delivery of up to 11 259 protein crystals with high spatial precision is presented. An experimental scheme for predetermining the positions of crystals in the chip by means of in situ spectroscopy using a fiducial system for rapid, precise alignment and registration of the crystal positions is presented. This delivers unprecedented performance in serial crystallography experiments at room temperature under atmospheric pressure, giving a raw hit rate approaching 100% with an effective indexing rate of approximately 50%, increasing the efficiency of beam usage and allowing the method to be applied to systems where the number of crystals is limited.

  15. Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography.

    PubMed

    Oghbaey, Saeed; Sarracini, Antoine; Ginn, Helen M; Pare-Labrosse, Olivier; Kuo, Anling; Marx, Alexander; Epp, Sascha W; Sherrell, Darren A; Eger, Bryan T; Zhong, Yinpeng; Loch, Rolf; Mariani, Valerio; Alonso-Mori, Roberto; Nelson, Silke; Lemke, Henrik T; Owen, Robin L; Pearson, Arwen R; Stuart, David I; Ernst, Oliver P; Mueller-Werkmeister, Henrike M; Miller, R J Dwayne

    2016-08-01

    The advent of ultrafast highly brilliant coherent X-ray free-electron laser sources has driven the development of novel structure-determination approaches for proteins, and promises visualization of protein dynamics on sub-picosecond timescales with full atomic resolution. Significant efforts are being applied to the development of sample-delivery systems that allow these unique sources to be most efficiently exploited for high-throughput serial femtosecond crystallography. Here, the next iteration of a fixed-target crystallography chip designed for rapid and reliable delivery of up to 11 259 protein crystals with high spatial precision is presented. An experimental scheme for predetermining the positions of crystals in the chip by means of in situ spectroscopy using a fiducial system for rapid, precise alignment and registration of the crystal positions is presented. This delivers unprecedented performance in serial crystallography experiments at room temperature under atmospheric pressure, giving a raw hit rate approaching 100% with an effective indexing rate of approximately 50%, increasing the efficiency of beam usage and allowing the method to be applied to systems where the number of crystals is limited. PMID:27487825

  16. Fixed-target protein serial microcrystallography with an x-ray free electron laser

    PubMed Central

    Hunter, Mark S.; Segelke, Brent; Messerschmidt, Marc; Williams, Garth J.; Zatsepin, Nadia A.; Barty, Anton; Benner, W. Henry; Carlson, David B.; Coleman, Matthew; Graf, Alexander; Hau-Riege, Stefan P.; Pardini, Tommaso; Seibert, M. Marvin; Evans, James; Boutet, Sébastien; Frank, Matthias

    2014-01-01

    We present results from experiments at the Linac Coherent Light Source (LCLS) demonstrating that serial femtosecond crystallography (SFX) can be performed to high resolution (~2.5 Å) using protein microcrystals deposited on an ultra-thin silicon nitride membrane and embedded in a preservation medium at room temperature. Data can be acquired at a high acquisition rate using x-ray free electron laser sources to overcome radiation damage, while sample consumption is dramatically reduced compared to flowing jet methods. We achieved a peak data acquisition rate of 10 Hz with a hit rate of ~38%, indicating that a complete data set could be acquired in about one 12-hour LCLS shift using the setup described here, or in even less time using hardware optimized for fixed target SFX. This demonstration opens the door to ultra low sample consumption SFX using the technique of diffraction-before-destruction on proteins that exist in only small quantities and/or do not produce the copious quantities of microcrystals required for flowing jet methods. PMID:25113598

  17. Fixed-target protein serial microcrystallography with an x-ray free electron laser.

    PubMed

    Hunter, Mark S; Segelke, Brent; Messerschmidt, Marc; Williams, Garth J; Zatsepin, Nadia A; Barty, Anton; Benner, W Henry; Carlson, David B; Coleman, Matthew; Graf, Alexander; Hau-Riege, Stefan P; Pardini, Tommaso; Seibert, M Marvin; Evans, James; Boutet, Sébastien; Frank, Matthias

    2014-01-01

    We present results from experiments at the Linac Coherent Light Source (LCLS) demonstrating that serial femtosecond crystallography (SFX) can be performed to high resolution (~2.5 Å) using protein microcrystals deposited on an ultra-thin silicon nitride membrane and embedded in a preservation medium at room temperature. Data can be acquired at a high acquisition rate using x-ray free electron laser sources to overcome radiation damage, while sample consumption is dramatically reduced compared to flowing jet methods. We achieved a peak data acquisition rate of 10 Hz with a hit rate of ~38%, indicating that a complete data set could be acquired in about one 12-hour LCLS shift using the setup described here, or in even less time using hardware optimized for fixed target SFX. This demonstration opens the door to ultra low sample consumption SFX using the technique of diffraction-before-destruction on proteins that exist in only small quantities and/or do not produce the copious quantities of microcrystals required for flowing jet methods.

  18. Fixed-target protein serial microcrystallography with an x-ray free electron laser.

    PubMed

    Hunter, Mark S; Segelke, Brent; Messerschmidt, Marc; Williams, Garth J; Zatsepin, Nadia A; Barty, Anton; Benner, W Henry; Carlson, David B; Coleman, Matthew; Graf, Alexander; Hau-Riege, Stefan P; Pardini, Tommaso; Seibert, M Marvin; Evans, James; Boutet, Sébastien; Frank, Matthias

    2014-01-01

    We present results from experiments at the Linac Coherent Light Source (LCLS) demonstrating that serial femtosecond crystallography (SFX) can be performed to high resolution (~2.5 Å) using protein microcrystals deposited on an ultra-thin silicon nitride membrane and embedded in a preservation medium at room temperature. Data can be acquired at a high acquisition rate using x-ray free electron laser sources to overcome radiation damage, while sample consumption is dramatically reduced compared to flowing jet methods. We achieved a peak data acquisition rate of 10 Hz with a hit rate of ~38%, indicating that a complete data set could be acquired in about one 12-hour LCLS shift using the setup described here, or in even less time using hardware optimized for fixed target SFX. This demonstration opens the door to ultra low sample consumption SFX using the technique of diffraction-before-destruction on proteins that exist in only small quantities and/or do not produce the copious quantities of microcrystals required for flowing jet methods. PMID:25113598

  19. A Novel Fixed-Target Task to Determine Articulatory Speed Constraints in Persons with Amyotrophic Lateral Sclerosis

    ERIC Educational Resources Information Center

    Mefferd, Antje S.; Green, Jordan R.; Pattee, Gary

    2012-01-01

    Purpose: The goal of this study was to determine if talkers with ALS are limited in their ability to increase lower lip and jaw speed at an early stage of the disease when their speaking rate and intelligibility are only minimally or not affected. Method: A novel metronome paced fixed-target task was used to assess movement speed capacities during…

  20. Spin physics and TMD studies at A Fixed-Target ExpeRiment at the LHC (AFTER@LHC)

    NASA Astrophysics Data System (ADS)

    Lansberg, J. P.; Anselmino, M.; Arnaldi, R.; Brodsky, S. J.; Chambert, V.; den Dunnen, W.; Didelez, J. P.; Genolini, B.; Ferreiro, E. G.; Fleuret, F.; Gao, Y.; Hadjidakis, C.; Hrvinacova, I.; Lorcé, C.; Massacrier, L.; Mikkelsen, R.; Pisano, C.; Rakotozafindrabe, A.; Rosier, P.; Schienbein, I.; Schlegel, M.; Scomparin, E.; Trzeciak, B.; Uggerhøj, U. I.; Ulrich, R.; Yang, Z.

    2015-01-01

    We report on the opportunities for spin physics and Transverse-Momentum Dependent distribution (TMD) studies at a future multi-purpose fixed-target experiment using the proton or lead ion LHC beams extracted by a bent crystal. The LHC multi-TeV beams allow for the most energetic fixed-target experiments ever performed, opening new domains of particle and nuclear physics and complementing that of collider physics, in particular that of RHIC and the EIC projects. The luminosity achievable with AFTER@LHC using typical targets would surpass that of RHIC by more that 3 orders of magnitude in a similar energy region. In unpolarised proton-proton collisions, AFTER@LHC allows for measurements of TMDs such as the Boer-Mulders quark distributions, the distribution of unpolarised and linearly polarised gluons in unpolarised protons. Using the polarisation of hydrogen and nuclear targets, one can measure transverse single-spin asymmetries of quark and gluon sensitive probes, such as, respectively, Drell-Yan pair and quarkonium production. The fixed-target mode has the advantage to allow for measurements in the target-rapidity region, namely at large x↑ in the polarised nucleon. Overall, this allows for an ambitious spin program which we outline here.

  1. An expression of interest in a Super Fixed Target Beauty Facility (SFT) at the Superconducting Super Collider

    SciTech Connect

    Not Available

    1990-05-25

    The concept of a Super Fixed Target Beauty Facility (SFT) which uses a relatively low intensity 20 TeV proton beam as a generator of very high momenta B's is an exciting prospect which is very competitive with other B factory ideas. The yields of B's in such a facility are quite high (3 {times} 10{sup 10} {yields} 10{sup 11} B's per year). At this level of statistics, CP violation measurements will be possible in many modes. In addition, the fixed target configuration, because of the high momenta of the produced B's and the resulting long decay lengths, facilitates the detection and reconstruction of B's and offers unique opportunities for observation of the B decays. The limited solid angle coverage required for the fixed target spectrometer makes the cost of the facility much cheaper than other e{sup +}e{sup {minus}} or hadron collider options under consideration. The relatively low intensity 20 TeV beam (1 {yields} 2 {times} 10{sup 8} protons/second) needed for the SFT makes it possible to consider an extraction system which operates concurrently and in a non-interfering manner with the other collider experiments. One possible method for generating such a beam, crystal channeling, is discussed.

  2. Supreme Court in Review--1996-97.

    ERIC Educational Resources Information Center

    Gregory, Gwendolyn H.

    1997-01-01

    In 1996 and 1997, the Supreme Court declared five acts of Congress to be unconstitutional. An overview of these decisions is offered in this article. It opens with a discussion of those acts that violated the First Amendment. These decisions dealt with the constitutionality of Arizona's "official English" statute; the Communications Decency Act,…

  3. Directory of Mississippi Libraries, 1996-97.

    ERIC Educational Resources Information Center

    Mississippi Library Commission, Jackson.

    The Directory of Mississippi Libraries is an annual publication which provides librarians, educators, and other interested persons with a basic source of current information on Mississippi libraries. The major section of the directory consists of listings for public, academic, school, special and institutional libraries. In addition to basic…

  4. Selected Reference Books of 1996-97.

    ERIC Educational Resources Information Center

    McIlvaine, Eileen

    1997-01-01

    Presents an annotated selection of recent scholarly and general reference works under the subject headings of biography, publishing, religion, popular culture, film and theater, literature, architecture, music, social sciences, archeology, history, and science, as well as new editions and supplements. (LRW)

  5. Deaf-Blind Perspectives. 1996-97.

    ERIC Educational Resources Information Center

    Deaf-Blind Perspectives, 1996

    1996-01-01

    Three issues of this newsletter include articles on and news items related to deaf-blindness. Articles include the following: "Research-to-Practice: Bridging the Gap between Research and Demonstration Projects and Practical Needs of Parents and Educators" (Harvey Mar and Nancy Sall); "Syndromes, Behavior, and Educational Intervention" (J. P. M.…

  6. Growing Fixed With Age: Lay Theories of Malleability Are Target Age-Specific.

    PubMed

    Neel, Rebecca; Lassetter, Bethany

    2015-11-01

    Beliefs about whether people can change ("lay theories" of malleability) are known to have wide-ranging effects on social motivation, cognition, and judgment. Yet rather than holding an overarching belief that people can or cannot change, perceivers may hold independent beliefs about whether different people are malleable-that is, lay theories may be target-specific. Seven studies demonstrate that lay theories are target-specific with respect to age: Perceivers hold distinct, uncorrelated lay theories of people at different ages, and younger targets are considered to be more malleable than older targets. Both forms of target-specificity are consequential, as target age-specific lay theories predict policy support for learning-based senior services and the rehabilitation of old and young drug users. The implications of target age-specific lay theories for a number of psychological processes, the social psychology of aging, and theoretical frameworks of malleability beliefs are discussed.

  7. Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.

    PubMed

    Steiner, Carine; Tille, Jean-Christophe; Lamerz, Jens; Kux van Geijtenbeek, Sabine; McKee, Thomas A; Venturi, Miro; Rubbia-Brandt, Laura; Hochstrasser, Denis; Cutler, Paul; Lescuyer, Pierre; Ducret, Axel

    2015-10-01

    The ability to accurately quantify proteins in formalin-fixed paraffin-embedded tissues using targeted mass spectrometry opens exciting perspectives for biomarker discovery. We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors. Peptide candidates were identified using an untargeted mass spectrometry approach in relevant cell lines. A multiplexed assay was developed for the six best candidate peptides and evaluated for linearity, precision and lower limit of quantification. Results showed a linear response over a calibration range of 0.012 to 100 fmol on column (R(2): 0.99-1.00).The lower limit of quantification was 0.155 fmol on column for all peptides evaluated. The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology. The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues. After normalization for sample size, selected reaction monitoring peptide measurements were able to correctly predict 90% of cases based on HER2 amplification as defined by the American Society of Clinical Oncology and College of American Pathologists. In conclusion, the developed assay showed good analytical performance and a high agreement with immunohistochemistry and fluorescence in situ hybridization data. This study demonstrated that selected reaction monitoring allows to accurately quantify protein expression in formalin-fixed paraffin-embedded tissues and represents therefore a powerful approach for biomarker discovery studies. The untargeted mass spectrometry

  8. Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.

    PubMed

    Steiner, Carine; Tille, Jean-Christophe; Lamerz, Jens; Kux van Geijtenbeek, Sabine; McKee, Thomas A; Venturi, Miro; Rubbia-Brandt, Laura; Hochstrasser, Denis; Cutler, Paul; Lescuyer, Pierre; Ducret, Axel

    2015-10-01

    The ability to accurately quantify proteins in formalin-fixed paraffin-embedded tissues using targeted mass spectrometry opens exciting perspectives for biomarker discovery. We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors. Peptide candidates were identified using an untargeted mass spectrometry approach in relevant cell lines. A multiplexed assay was developed for the six best candidate peptides and evaluated for linearity, precision and lower limit of quantification. Results showed a linear response over a calibration range of 0.012 to 100 fmol on column (R(2): 0.99-1.00).The lower limit of quantification was 0.155 fmol on column for all peptides evaluated. The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology. The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues. After normalization for sample size, selected reaction monitoring peptide measurements were able to correctly predict 90% of cases based on HER2 amplification as defined by the American Society of Clinical Oncology and College of American Pathologists. In conclusion, the developed assay showed good analytical performance and a high agreement with immunohistochemistry and fluorescence in situ hybridization data. This study demonstrated that selected reaction monitoring allows to accurately quantify protein expression in formalin-fixed paraffin-embedded tissues and represents therefore a powerful approach for biomarker discovery studies. The untargeted mass spectrometry

  9. HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

    PubMed

    Moens, Lotte N J; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; Sundström, Magnus; La Fleur, Linnéa; Mathot, Lucy; Micke, Patrick; Nilsson, Mats; Botling, Johan

    2015-11-01

    In recent years, the advent of massively parallel next-generation sequencing technologies has enabled substantial advances in the study of human diseases. Combined with targeted DNA enrichment methods, high sequence coverage can be obtained for different genes simultaneously at a reduced cost per sample, creating unique opportunities for clinical cancer diagnostics. However, the formalin-fixed, paraffin-embedded (FFPE) process of tissue samples, routinely used in pathology departments, results in DNA fragmentation and nucleotide modifications that introduce a number of technical challenges for downstream biomolecular analyses. We evaluated the HaloPlex target enrichment system for somatic mutation detection in 80 tissue fractions derived from 20 clinical cancer cases with paired tumor and normal tissue available in both FFPE and fresh-frozen format. Several modifications to the standard method were introduced, including a reduced target fragment length and two strand capturing. We found that FFPE material can be used for HaloPlex-based target enrichment and next-generation sequencing, even when starting from small amounts of DNA. By specifically capturing both strands for each target fragment, we were able to reduce the number of false-positive errors caused by FFPE-induced artifacts and lower the detection limit for somatic mutations. We believe that the HaloPlex method presented here will be broadly applicable as a tool for somatic mutation detection in clinical cancer settings.

  10. HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

    PubMed

    Moens, Lotte N J; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; Sundström, Magnus; La Fleur, Linnéa; Mathot, Lucy; Micke, Patrick; Nilsson, Mats; Botling, Johan

    2015-11-01

    In recent years, the advent of massively parallel next-generation sequencing technologies has enabled substantial advances in the study of human diseases. Combined with targeted DNA enrichment methods, high sequence coverage can be obtained for different genes simultaneously at a reduced cost per sample, creating unique opportunities for clinical cancer diagnostics. However, the formalin-fixed, paraffin-embedded (FFPE) process of tissue samples, routinely used in pathology departments, results in DNA fragmentation and nucleotide modifications that introduce a number of technical challenges for downstream biomolecular analyses. We evaluated the HaloPlex target enrichment system for somatic mutation detection in 80 tissue fractions derived from 20 clinical cancer cases with paired tumor and normal tissue available in both FFPE and fresh-frozen format. Several modifications to the standard method were introduced, including a reduced target fragment length and two strand capturing. We found that FFPE material can be used for HaloPlex-based target enrichment and next-generation sequencing, even when starting from small amounts of DNA. By specifically capturing both strands for each target fragment, we were able to reduce the number of false-positive errors caused by FFPE-induced artifacts and lower the detection limit for somatic mutations. We believe that the HaloPlex method presented here will be broadly applicable as a tool for somatic mutation detection in clinical cancer settings. PMID:26354930

  11. Dosimetric comparison of split field and fixed jaw techniques for large IMRT target volumes in the head and neck.

    PubMed

    Srivastava, Shiv P; Das, Indra J; Kumar, Arvind; Johnstone, Peter A S

    2011-01-01

    Some treatment planning systems (TPSs), when used for large-field (>14 cm) intensity-modulated radiation therapy (IMRT), create split fields that produce excessive multiple-leaf collimator segments, match-line dose inhomogeneity, and higher treatment times than nonsplit fields. A new method using a fixed-jaw technique (FJT) forces the jaw to stay at a fixed position during optimization and is proposed to reduce problems associated with split fields. Dosimetric comparisons between split-field technique (SFT) and FJT used for IMRT treatment is presented. Five patients with head and neck malignancies and regional target volumes were studied and compared with both techniques. Treatment planning was performed on an Eclipse TPS using beam data generated for Varian 2100C linear accelerator. A standard beam arrangement consisting of nine coplanar fields, equally spaced, was used in both techniques. Institutional dose-volume constraints used in head and neck cancer were kept the same for both techniques. The dosimetric coverage for the target volumes between SFT and FJT for head and neck IMRT plan is identical within ± 1% up to 90% dose. Similarly, the organs at risk (OARs) have dose-volume coverage nearly identical for all patients. When the total monitor unit (MU) and segments were analyzed, SFT produces statistically significant higher segments (17.3 ± 6.3%) and higher MU (13.7 ± 4.4%) than the FJT. There is no match line in FJT and hence dose uniformity in the target volume is superior to the SFT. Dosimetrically, SFT and FJT are similar for dose-volume coverage; however, the FJT method provides better logistics, lower MU, shorter treatment time, and better dose uniformity. The number of segments and MU also has been correlated with the whole body radiation dose with long-term complications. Thus, FJT should be the preferred option over SFT for large target volumes.

  12. Dosimetric Comparison of Split Field and Fixed Jaw Techniques for Large IMRT Target Volumes in the Head and Neck

    SciTech Connect

    Srivastava, Shiv P.; Das, Indra J.; Kumar, Arvind; Johnstone, Peter A.S.

    2011-04-01

    Some treatment planning systems (TPSs), when used for large-field (>14 cm) intensity-modulated radiation therapy (IMRT), create split fields that produce excessive multiple-leaf collimator segments, match-line dose inhomogeneity, and higher treatment times than nonsplit fields. A new method using a fixed-jaw technique (FJT) forces the jaw to stay at a fixed position during optimization and is proposed to reduce problems associated with split fields. Dosimetric comparisons between split-field technique (SFT) and FJT used for IMRT treatment is presented. Five patients with head and neck malignancies and regional target volumes were studied and compared with both techniques. Treatment planning was performed on an Eclipse TPS using beam data generated for Varian 2100C linear accelerator. A standard beam arrangement consisting of nine coplanar fields, equally spaced, was used in both techniques. Institutional dose-volume constraints used in head and neck cancer were kept the same for both techniques. The dosimetric coverage for the target volumes between SFT and FJT for head and neck IMRT plan is identical within {+-}1% up to 90% dose. Similarly, the organs at risk (OARs) have dose-volume coverage nearly identical for all patients. When the total monitor unit (MU) and segments were analyzed, SFT produces statistically significant higher segments (17.3 {+-} 6.3%) and higher MU (13.7 {+-} 4.4%) than the FJT. There is no match line in FJT and hence dose uniformity in the target volume is superior to the SFT. Dosimetrically, SFT and FJT are similar for dose-volume coverage; however, the FJT method provides better logistics, lower MU, shorter treatment time, and better dose uniformity. The number of segments and MU also has been correlated with the whole body radiation dose with long-term complications. Thus, FJT should be the preferred option over SFT for large target volumes.

  13. A framework to analyze searches for gauge bosons of the hidden light sector in electron scattering fixed target experiments

    SciTech Connect

    Beranek, T.

    2013-11-07

    Electron scattering fixed target experiments are a versatile tool to probe various kinds of physics phenomena. Recently fixed target experiments in which an electron beam is scattered off a heavy nucleus and a lepton-antilepton pair is created, i.e. e(A,Z) →e(A,Z)l{sup +}l{sup −}, were utilized to search for physics beyond the standard model at modest energies. In these experiments one searches for a small, narrow resonance in the invariant mass spectrum of the lepton-antilepton pair, arising from the exchange of a new light gauge boson γ′ coupling to the dark sector as well as very weakly to standard model particles. Such a signal would appear as an enhancement over a smooth QED background. Hence a precise understanding of the background is crucial. We present a theoretical analysis of the process e(A,Z) →e(A,Z)l{sup +}l{sup −}. Therefore we have performed an analysis of the cross section, which is then used to extract exclusion limits on the parameter space of the γ′, describing the existing experimental data taken at MAMI.

  14. Studies of the LBL CMOS integrated amplifier/discriminator for randomly timed inputs from fixed target experiments

    SciTech Connect

    Russ, J.S.; Yarema, R.J.; Zimmerman, T.

    1988-12-01

    A group at Lawrence Berkeley Laboratory has reported an elegant CMOS VLSI circuit for amplifying, discriminating, and encoding the signals from highly-segmented charge output devices, e.g., silicon strip detectors or pad readout structures in gaseous detectors. The design exploits switched capacitor circuits and the well-known time structure of data acquisition in colliding beam accelerators to cancel leakage effects and switching noise. For random inputs, these methods are not directly applicable. However, the high speed of the reset switches makes possible a mode of operation for fixed target experiments that uses fast resets to erase unwanted data from random triggers. Data acquisition in this mode has been performed. Details of operation and measurements of noise and rate capability will be presented. 8 refs., 6 figs.

  15. Measurement of the ϒ production cross section in 920 GeV fixed-target proton nucleus collisions

    NASA Astrophysics Data System (ADS)

    Hera-B Collaboration; Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; de Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Groth-Jensen, J.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; Zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. Aa.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zech, G.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.

    2006-06-01

    The cross section ratio R=Br(ϒ→ll)ṡdσ(ϒ)/dy|y=0/σ(J/ψ) has been measured with the HERA-B spectrometer in fixed-target proton nucleus collisions at 920 GeV proton beam energy corresponding to a proton nucleon c.m.s. energy of s=41.6 GeV. The combined results for the decay channels ϒ→ee and ϒ→μμ yield a ratio R=(9.0±2.1)×10. The corresponding ϒ production cross section per nucleon at mid-rapidity (y=0) has been determined to be Br(ϒ→ll)ṡdσ(ϒ)/dy|y=0=4.5±1.1 pb/nucleon.

  16. Measurement of the ϒ production cross section in 920 GeV fixed-target proton-nucleus collisions

    NASA Astrophysics Data System (ADS)

    Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; De Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Groth-Jensen, J.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. AA.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zech, G.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.; HERA-B Collaboration

    2006-06-01

    The cross section ratio RJ / ψ = Br (ϒ →l+l-) ṡ dσ (ϒ) / dy|y = 0 / σ (J / ψ) has been measured with the HERA-B spectrometer in fixed-target proton-nucleus collisions at 920 GeV proton beam energy corresponding to a proton-nucleon c.m.s. energy of √{ s} = 41.6 GeV. The combined results for the decay channels ϒ →e+e- and ϒ →μ+μ- yield a ratio RJ / ψ = (9.0 ± 2.1) ×10-6. The corresponding ϒ production cross section per nucleon at mid-rapidity (y = 0) has been determined to be Br (ϒ →l+l-) ṡ dσ (ϒ) / dy|y = 0 = 4.5 ± 1.1 pb /nucleon.

  17. Performance of the SLC polarized electron source and injector with the SLAC 3 km linac configured for fixed target experiments

    SciTech Connect

    Yeremian, A.D.; Alley, R.K.; Clendenin, J.E.

    1993-03-01

    The SLC polarized electron source (PES) can be modified to produce {mu}sec-long pulses for injection into the un-SLEDed SLAC 3 km linac, with a duty factor considerably higher than for SLC. Such beams are desirable for fixed target experiments at SLAC requiring polarized electron beams of up to 50 mA within an energy spread of 0.5%, at energies of up to 26 GeV. During the fall of 1992, the SLAC linac was operated continuously for two months unSLEDed with the PES dye laser (715 nm) modified to produce a 1{mu}ec pulse at 120Hz. An AlGaAs photocathode was installed in the electron gun to achieve 40% polarization, and a prebuncher was added to the SLC injector to improve capture for long pulse beams. We discuss the performance eo the polarized electron beam for long pulse operation.

  18. Identification of Cold-Responsive miRNAs and Their Target Genes in Nitrogen-Fixing Nodules of Soybean

    PubMed Central

    Zhang, Senlei; Wang, Youning; Li, Kexue; Zou, Yanmin; Chen, Liang; Li, Xia

    2014-01-01

    As a warm climate species, soybean is highly sensitive to chilling temperatures. Exposure to chilling temperatures causes a significant reduction in the nitrogen fixation rate in soybean plants and subsequent yield loss. However, the molecular basis for the sensitivity of soybean to chilling is poorly understood. In this study, we identified cold-responsive miRNAs in nitrogen-fixing nodules of soybean. Upon chilling, the expression of gma-miR397a, gma-miR166u and gma-miR171p was greatly upregulated, whereas the expression of gma-miR169c, gma-miR159b, gma-miR319a/b and gma-miR5559 was significantly decreased. The target genes of these miRNAs were predicted and validated using 5' complementary DNA ends (5'-RACE) experiments, and qPCR analysis identified putative genes targeted by the cold-responsive miRNAs in response to chilling temperatures. Taken together, our results reveal that miRNAs may be involved in the protective mechanism against chilling injury in mature nodules of soybean. PMID:25100171

  19. The muon component in extensive air showers and new p+C data in fixed target experiments

    SciTech Connect

    Meurer, C.; Bluemer, J.; Engel, R.; Haungs, A.; Roth, M.

    2007-03-19

    One of the most promising approaches to determine the energy spectrum and composition of the cosmic rays with energies above 1015 eV is the measurement of the number of electrons and muons produced in extensive air showers (EAS). Therefore simulation of air showers using electromagnetic and hadronic interaction models are necessary. These simulations show uncertainties which come mainly from hadronic interaction models. One aim of this work is to specify the low energy hadronic interactions which are important for the muon production in EAS. Therefore we simulate extensive air showers with a modified version of the simulation package CORSIKA. In particular we investigate in detail the energy and the phase space regions of secondary particle production, which are most important for muon production. This phase space region is covered by fixed target experiments at CERN. In the second part of this work we present preliminary momentum spectra of secondary {pi}+ and {pi}- in p+C collisions at 12 GeV/c measured with the HARP spectrometer at the PS accelerator at CERN. In addition we use the new p+C NA49 data at 158 GeV/c to check the reliability of hadronic interaction models for muon production in EAS. Finally, possibilities to measure relevant quantities of hadron production in existing and planned accelerator experiments are discussed.

  20. Effects of azimuth-symmetric acceptance cutoffs on the measured asymmetry in unpolarized Drell-Yan fixed-target experiments

    NASA Astrophysics Data System (ADS)

    Bianconi, A.; Bussa, M. P.; Destefanis, M.; Ferrero, L.; Greco, M.; Maggiora, M.; Spataro, S.

    2013-04-01

    Fixed-target unpolarized Drell-Yan experiments often feature an acceptance depending on the polar angle of the lepton tracks in the laboratory frame. Typically leptons are detected in a defined angular range, with a dead zone in the forward region. If the cutoffs imposed by the angular acceptance are independent of the azimuth, at first sight they do not appear dangerous for a measurement of the cos(2 φ) asymmetry, which is relevant because of its association with the violation of the Lam-Tung rule and with the Boer-Mulders function. On the contrary, direct simulations show that up to 10 percent asymmetries are produced by these cutoffs. These artificial asymmetries present qualitative features that allow them to mimic the physical ones. They introduce some model dependence in the measurements of the cos(2 φ) asymmetry, since a precise reconstruction of the acceptance in the Collins-Soper frame requires a Monte Carlo simulation, that in turn requires some detailed physical input to generate event distributions. Although experiments in the eighties seem to have been aware of this problem, the possibility of using the Boer-Mulders function as an input parameter in the extraction of transversity has much increased the requirements of precision on this measurement. Our simulations show that the safest approach to these measurements is a strong cutoff on the Collins-Soper polar angle. This reduces statistics, but does not necessarily decrease the precision in a measurement of the Boer-Mulders function.

  1. Studies of Transverse-Momentum-Dependent Distributions with a Fixed-Target ExpeRiment Using the LHC Beams (AFTER@LHC)

    NASA Astrophysics Data System (ADS)

    Massacrier, L.; Anselmino, M.; Arnaldi, R.; Brodsky, S. J.; Chambert, V.; den Dunnen, W.; Didelez, J. P.; Genolini, B.; Ferreiro, E. G.; Fleuret, F.; Gao, Y.; Hadjidakis, C.; Hřivnáčová, I.; Lansberg, J. P.; Lorcé, C.; Mikkelsen, R.; Pisano, C.; Rakotozafindrabe, A.; Rosier, P.; Schienbein, I.; Schlegel, M.; Scomparin, E.; Trzeciak, B.; Uggerhøj, U. I.; Ulrich, R.; Yang, Z.

    2016-02-01

    We report on the studies of Transverse-Momentum-Dependent distributions (TMDs) at a future fixed-target experiment -AFTER@LHC- using the p+ or Pb ion LHC beams, which would be the most energetic fixed-target experiment ever performed. AFTER@LHC opens new domains of particle and nuclear physics by complementing collider-mode experiments, in particular those of RHIC and the EIC projects. Both with an extracted beam by a bent crystal or with an internal gas target, the luminosity achieved by AFTER@LHC surpasses that of RHIC by up to 3 orders of magnitude. With an unpolarised target, it allows for measurements of TMDs such as the Boer-Mulders quark distributions and the distribution of unpolarised and linearly polarised gluons in unpolarised protons. Using polarised targets, one can access the quark and gluon Sivers TMDs through single transverse-spin asymmetries in Drell-Yan and quarkonium production. In terms of kinematics, the fixed-target mode combined with a detector covering ηlab ∈ [1, 5] allows one to measure these asymmetries at large x↑ in the polarised nucleon.

  2. Membrane targeting of MnSOD is essential for oxidative stress tolerance of nitrogen-fixing cultures of Anabaena sp. strain PCC7120.

    PubMed

    Raghavan, Prashanth S; Rajaram, Hema; Apte, Shree Kumar

    2015-07-01

    The nitrogen-fixing cyanobacterium, Anabaena PCC7120 encodes for a membrane-targeted 30 kDa Mn-superoxide dismutase (MnSOD) and a cytosolic FeSOD. The MnSOD is post-translationally processed to 27 and 24 kDa forms in the cytosol and periplasm/thylakoid lumen. The extent of cleavage of signal and linker peptides at the N-terminus is dependent on the availability of combined nitrogen during growth. While the 24 and 27 kDa forms are present in near equal proportions under nitrogen-fixing conditions, the 24 kDa form is predominant under nitrogen-supplemented conditions. Individual contribution of these forms of MnSOD to total oxidative stress tolerance was analysed using recombinant Anabaena strains overexpressing either different molecular forms of MnSOD or MnSOD defective in the cleavage of signal/linker peptide. Targeting of MnSOD to the membrane and subsequent cleavage to release both the 24 and 27 kDa forms was essential for oxidative stress tolerance under nitrogen-fixing conditions. On the other hand, the cleavage of linker peptide was absolutely essential and the release of cytosolic 24 kDa form of MnSOD was obligatory for developing oxidative stress tolerance under nitrogen-supplemented conditions. Thus, a single MnSOD caters to the reduction of superoxide radical in both cytosol and thylakoid lumen/periplasm irrespective of the N-status of growth by regulating its cleavage. This is the first report on the physiological advantage of membrane-targeting and processing of MnSOD in either bacteria or plants. The higher oxidative stress tolerance offered by the cytosolic form of MnSOD has possibly resulted in retention of only the cytosolic form in bacterial non-nitrogen-fixers during evolution.

  3. Generalization of vestibular learning to earth-fixed targets is possible but limited when the polarity of afferent vestibular information is changed.

    PubMed

    Mackrous, I; Simoneau, M

    2014-02-28

    To maintain perception of the world around us during body motion, the brain must update the spatial presentation of visual stimuli, known as space updating. Previous studies have demonstrated that vestibular signals contribute to space updating. Nonetheless, when being passively rotated in the dark, the ability to keep track of a memorized earth-fixed target (EFT) involves learning mechanism(s). We tested whether such learning generalizes across different EFT eccentricities. Furthermore, we ascertained whether learning transfers to similar target eccentricities but in the opposite direction. Participants were trained to predict the position of an EFT (located at 45° to their left) while being rotated counterclockwise (i.e., they press a push button when they perceived that their body midline have cross the position of the target). Overall, the results indicated that learning transferred to other target eccentricity (30° and 60°) for identical body rotation direction. In contrast, vestibular learning partly transferred to target location's matching body rotation but in the opposite rotation direction. Generalization of learning implies that participants do not adopt cognitive strategies to improve their performance during training. We argue that the brain learned to use vestibular signals for space updating. Generalization of learning while being rotated in the opposite direction implies that some parts of the neural networks involved in space updating is shared between trained and untrained direction.

  4. New prospects in fixed target searches for dark forces with the SeaQuest experiment at Fermilab

    NASA Astrophysics Data System (ADS)

    Gardner, S.; Holt, R. J.; Tadepalli, A. S.

    2016-06-01

    An intense 120 GeV proton beam incident on an extremely long iron target generates enormous numbers of light-mass particles that also decay within that target. If one of these particles decays to a final state with a hidden gauge boson, or if such a particle is produced as a result of the initial collision, then that weakly interacting hidden-sector particle may traverse the remainder of the target and be detected downstream through its possible decay to an e+e-, μ+μ-, or π+π- final state. These conditions can be realized through an extension of the SeaQuest experiment at Fermilab, and in this initial investigation we consider how it can serve as an ultrasensitive probe of hidden vector gauge forces, both Abelian and non-Abelian. A light, weakly coupled hidden sector may well explain the dark matter established through astrophysical observations, and the proposed search can provide tangible evidence for its existence—or, alternatively, constrain a "sea" of possibilities.

  5. Measurement of D0, D+, Ds + and D*+ production in fixed target 920 GeV proton nucleus collisions

    NASA Astrophysics Data System (ADS)

    Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, T. S.; Belkov, A.; Belkov, A.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; de Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, L.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Groth-Jensen, J.; Guilitsky, Y.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Y.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Y.; Mizuk, R.; Muresan, R.; Zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. A. A.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Škrk, D.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Y.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Xella-Hansen, S.; Zaitsev, Y.; Zavertyaev, M.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.

    2007-11-01

    The inclusive production cross sections of the charmed mesons D0,D+,Ds + and D*+ have been measured in interactions of 920 GeV protons on C, Ti, and W targets with the HERA-B detector at the HERA storage ring. Differential cross sections as a function of transverse momentum and Feynman’s x variable are given for the central rapidity region and for transverse momenta up to pT=3.5 GeV/ c. The atomic mass number dependence and the leading to non-leading particle production asymmetries are presented as well.

  6. Polarization of Λ and Λ¯ in 920 GeV fixed-target proton nucleus collisions

    NASA Astrophysics Data System (ADS)

    Hera-B Collaboration; Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; de Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Erhan, S.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; Zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. Aa.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.

    2006-07-01

    A measurement of the polarization of Λ and Λ¯ baryons produced in pC and pW collisions at s=41.6 GeV has been performed with the HERA-B spectrometer. The measurements cover the kinematic range of 0.6 GeV/ctargets agree within the statistical error. In the combined data set, the largest deviation from zero, +0.054±0.029, is measured for x≲-0.07. Zero polarization is expected at x=0 in the absence of nuclear effects. The polarization results for the Λ agree with a parametrization of previous measurements which were performed at positive x values, where the Λ polarization is negative. Results of Λ¯ polarization measurements are consistent with zero.

  7. Experimental Facilities Division progress report 1996--97

    SciTech Connect

    1997-04-01

    This progress report summarizes the activities of the Experimental Facilities Division (XFD) in support of the users of the Advanced Photon Source (APS), primarily focusing on the past year of operations. In September 1996, the APS began operations as a national user facility serving the US community of x-ray researchers from private industry, academic institutions, and other research organizations. The start of operations was about three months ahead of the baseline date established in 1988. This report is divided into the following sections: (1) overview; (2) user operations; (3) user administration and technical support; (4) R and D in support of view operations; (5) collaborative research; and (6) long-term strategic plans for XFD.

  8. Advanced Light Source activity report 1996/97

    SciTech Connect

    1997-09-01

    Ten years ago, the Advanced Light Source (ALS) existed as a set of drawings, calculations, and ideas. Four years ago, it stored an electron beam for the first time. Today, the ALS has moved from those ideas and beginnings to a robust, third-generation synchrotron user facility, with eighteen beam lines in use, many more in planning or construction phases, and hundreds of users from around the world. Progress from concepts to realities is continuous as the scientific program, already strong in many diverse areas, moves in new directions to meet the needs of researchers into the next century. ALS staff members who develop and maintain the infrastructure for this research are similarly unwilling to rest on their laurels. As a result, the quality of the photon beams the authors deliver, as well as the support they provide to users, continues to improve. The ALS Activity Report is designed to share the results of these efforts in an accessible form for a broad audience. The Scientific Program section, while not comprehensive, shares the breadth, variety, and interest of recent research at the ALS. (The Compendium of User Abstracts and Technical Reports provides a more comprehensive and more technical view.) The Facility Report highlights progress in operations, ongoing accelerator research and development, and beamline instrumentation efforts. Although these Activity Report sections are separate, in practice the achievements of staff and users at the ALS are inseparable. User-staff collaboration is essential as they strive to meet the needs of the user community and to continue the ALS's success as a premier research facility.

  9. Academic and Special Libraries in Idaho. 1996/97 Directory.

    ERIC Educational Resources Information Center

    Brandt, Sandy, Comp.

    This directory provides a concise list of academic and special libraries in Idaho. Libraries are listed alphabetically, and include library contact name, title, telephone, fax number, and address. The directory also contains an alphabetical listing of the library contacts, which includes the name of the library where the person works and the…

  10. The Hispanic Outlook in Higher Education, 1996-97.

    ERIC Educational Resources Information Center

    Hixson, Adalyn, Ed.; Gilroy, Marilyn, Ed.

    1997-01-01

    This document consists of all of Volume 7 (26 issues) of the journal, "The Hispanic Outlook in Higher Education," a biweekly journal that addresses issues in higher education for Hispanic Americans. Each issue presents several feature articles, a policy update called "Outlook on Washington," and a sample student success story. Major articles…

  11. 1996--97 buying guide: Power plant products and services

    SciTech Connect

    1996-09-01

    This is a buying guide/directory of power plant products and services. The guide includes a product index and a directory of product suppliers and manufacturers with the information necessary for making contact; and index of services and a directory of businesses providing the services with the information necessary for making contact with them.

  12. Planning 1997-98, Progress 1996-97. Annual Report.

    ERIC Educational Resources Information Center

    Platt, Gail M.

    Established in fall 1980, TheLearningCenter at South Plains College, in Texas, is designed to provide assistance to students seeking specialized services, offering developmental and college-level courses, peer-tutoring, computer-aided instruction, learning opportunities, and learning assessments. This annual report describes instructional…

  13. Financial Report of Ontario Universities 1996-97. Supplementary Volume.

    ERIC Educational Resources Information Center

    Council of Ontario Universities, Toronto.

    This volume provides supplementary data to the annual report for 43 provincially assisted universities, colleges, and church-related institutions of higher education in Ontario, Canada. The information includes further details concerning various sources of revenue, including grants from the major funding agencies of the federal government, as well…

  14. Clean coal technology demonstration program: Program update 1996-97

    SciTech Connect

    1997-10-01

    The Clean Coal Technology Demonstration Program (known as the CCT Program) reached a significant milestone in 1996 with the completion of 20 of the 39 active projects. The CCT Program is responding to a need to demonstrate and deploy a portfolio of technologies that will assure the U.S. recoverable coal reserves of 297 billion tons could continue to supply the nation`s energy needs economically and in a manner that meets the nation`s environmental objectives. This portfolio of technologies includes environmental control devices that contributed to meeting the accords on transboundary air pollution recommended by the Special Envoys on Acid Rain in 1986. Operational, technical, environmental, and economic performance information and data are now flowing from highly efficient, low-emission, advanced power generation technologies that will enable coal to retain its prominent role into the next millennium. Further, advanced technologies are emerging that will enhance the competitive use of coal in the industrial sector, such as in steelmaking. Coal processing technologies will enable the entire coal resource base to be used while complying with environmental requirements. These technologies are producing products used by utilities and industrial processes. The capability to coproduce products, such as liquid and solid fuels, electricity, and chemicals, is being demonstrated at a commercial scale by projects in the CCT Program. In summary, this portfolio of technologies is satisfying the national need to maintain a multifuel energy mix in which coal is a key component because of its low-cost, availability, and abundant supply within the nation`s borders.

  15. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

    DOE PAGES

    Sherrell, Darren A.; Foster, Andrew J.; Hudson, Lee; Nutter, Brian; O'Hea, James; Nelson, Silke; Pare-Labrosse, Olivier; Oghbaey, Saeed; Miller, R. J. Dwayne; Owen, Robin L.

    2015-01-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with themore » stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.« less

  16. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

    SciTech Connect

    Sherrell, Darren A.; Foster, Andrew J.; Hudson, Lee; Nutter, Brian; O'Hea, James; Nelson, Silke; Pare-Labrosse, Olivier; Oghbaey, Saeed; Miller, R. J. Dwayne; Owen, Robin L.

    2015-01-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. Lastly, the setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply.

  17. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources.

    PubMed

    Sherrell, Darren A; Foster, Andrew J; Hudson, Lee; Nutter, Brian; O'Hea, James; Nelson, Silke; Paré-Labrosse, Olivier; Oghbaey, Saeed; Miller, R J Dwayne; Owen, Robin L

    2015-11-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply. PMID:26524301

  18. A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources

    PubMed Central

    Sherrell, Darren A.; Foster, Andrew J.; Hudson, Lee; Nutter, Brian; O’Hea, James; Nelson, Silke; Paré-Labrosse, Olivier; Oghbaey, Saeed; Miller, R. J. Dwayne; Owen, Robin L.

    2015-01-01

    The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free-electron laser (FEL) sources and its performance are described. The system provides the ability to quickly and reliably deliver large numbers of samples using the minimum amount of sample possible, through positioning of fixed target arrays into the X-ray beam. The combination of high-precision stages, high-quality sample viewing, a fast controller and a software layer overcome many of the challenges associated with sample alignment. A straightforward interface that minimizes setup and sample changeover time as well as simplifying communication with the stages during the experiment is also described, together with an intuitive naming convention for defining, tracking and locating sample positions. The setup allows the precise delivery of samples in predefined locations to a specific position in space and time, reliably and simply. PMID:26524301

  19. Polarization of Λ and Λbar in 920 GeV fixed-target proton-nucleus collisions

    NASA Astrophysics Data System (ADS)

    Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; De Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Erhan, S.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. AA.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.; HERA-B Collaboration

    2006-07-01

    A measurement of the polarization of Λ and Λbar baryons produced in pC and pW collisions at √{ s} = 41.6 GeV has been performed with the HERA-B spectrometer. The measurements cover the kinematic range of 0.6 GeV / c targets agree within the statistical error. In the combined data set, the largest deviation from zero, + 0.054 ± 0.029, is measured for xF ≲ - 0.07. Zero polarization is expected at xF = 0 in the absence of nuclear effects. The polarization results for the Λ agree with a parametrization of previous measurements which were performed at positive xF values, where the Λ polarization is negative. Results of Λbar polarization measurements are consistent with zero.

  20. The data acquisition system for a fixed target experiment at NICA complex at JINR and its connection to the ATLAS TileCal readout electronics

    NASA Astrophysics Data System (ADS)

    Tomiwa, K. G.; Slepnev, I.; Bazylev, S.

    2015-10-01

    Today's large-scale science projects have always encountered challenges in processing large data flow from the experiments, the ATLAS detector records proton-proton collisions provided by the Large Hadron Collider (LHC) at CERN every 50 ns which results in a total data flow of 10 Pb/s. These data must be reduced to the science data product for further analysis, thus a very fast decisions need to be executed, to modify this large amounts of data at high rates. The capabilities required to support this scale of data movement is development and improvement of high-throughput electronics. The upgraded LHC will provide collisions at rates that will be at least 10 times higher than those of today due to it's luminosity by 2022. This will require a complete redesign of the read-out electronics and Processing Units (PU) in the Tile-calorimeter (TileCal) of the ATLAS experiment. A general purpose, high-throughput PU has been developed for the TileCal at CERN, by using several ARM-processors in cluster configuration. The PU is capable of handling large data throughput and apply advanced operations at high rates. This system has been proposed for the fixed target experiment at NICA complex to handle the first level processes and event building. The aim of this work is to have a look at the architecture of the data acquisition system (DAQ) of the fixed target experiment at the NICA complex at JINR, by compiling the data-flow requirements of all the subcomponents. Furthermore, the VME DAQ modules characteristics to control, triggering and data acquisition will be described in order to define the DAQ with maximum readout efficiency, no dead time and data selection and compression.

  1. An Electron Fixed Target Experiment to Search for a New Vector Boson A' Decaying to e+e-

    SciTech Connect

    Essig, Rouven; Schuster, Philip; Toro, Natalia; Wojtsekhowski, Bogdan; /Jefferson Lab

    2010-06-11

    We describe an experiment to search for a new vector boson A' with weak coupling {alpha}' {approx}> 6 x 10{sup -8} {alpha} to electrons ({alpha} = e{sup 2}/4{pi}) in the mass range 65 MeV < m{sub A'} < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the 'dark photon' A' with the photon - one of the very few ways in which new forces can couple to the Standard Model - and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiation off an electron beam, and could appear as narrow resonances with small production cross-section in the trident e{sup +}e{sup -} spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of {approx} 1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e{sup +}e{sup -} pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a {approx} 1 month run, APEX will achieve very good sensitivity because the statistics of e{sup +}e{sup -} pairs will be {approx} 10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to {alpha}'/{alpha} one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.

  2. An electron fixed target experiment to search for a new vector boson A' decaying to e+e-

    DOE PAGES

    Rouven Essig; Schuster, Philip; Toro, Natalia; Wojtsekhowski, Bogdan

    2011-02-02

    We describe an experiment to search for a new vector boson A' with weak coupling alpha' > 6 x 10–8 α to electrons (α' = e2/4π) in the mass range 65 MeV < mA' < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the "dark photon" A' with the photon -- one of the very few ways in which new forces can couple to the Standard Model -- and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiation off an electronmore » beam, and could appear as narrow resonances with small production cross-section in the trident e+e- spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of ~1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e+e- pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a ~1 month run, APEX will achieve very good sensitivity because the statistics of e+e- pairs will be ~10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to α'/α one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.« less

  3. Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material

    PubMed Central

    Koudijs, Marco J.; Nijman, Ies; Hinrichs, John W. J.; Cuppen, Edwin; van Lieshout, Stef; Loberg, Robert D.; de Jonge, Maja; Voest, Emile E.; de Weger, Roel A.; Steeghs, Neeltje; Langenberg, Marlies H. G.; Sleijfer, Stefan; Willems, Stefan M.; Lolkema, Martijn P.

    2016-01-01

    Background Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have been defined. This study therefore aimed to determine the effect of the type of input material (e.g. formalin fixed paraffin embedded (FFPE) versus fresh frozen (FF) tissue) on NGS derived results. Moreover, this study aimed to explore a standardized analysis pipeline to support consistent clinical decision-making. Method We used the Ion Torrent PGM sequencing platform in combination with the Ion AmpliSeq Cancer Hotspot Panel v2 to sequence frequently mutated regions in 50 cancer related genes, and validated the NGS detected variants in 250 FFPE samples using standard diagnostic assays. Next, 386 tumour samples were sequenced to explore the effect of input material on variant detection variables. For variant calling, Ion Torrent analysis software was supplemented with additional variant annotation and filtering. Results Both FFPE and FF tissue could be sequenced reliably with a sensitivity of 99.1%. Validation showed a 98.5% concordance between NGS and conventional sequencing techniques, where NGS provided both the advantage of low input DNA concentration and the detection of low-frequency variants. The reliability of mutation analysis could be further improved with manual inspection of sequence data. Conclusion Targeted NGS can be reliably implemented in cancer diagnostics using both FFPE and FF tissue when using appropriate analysis settings, even with low input DNA. PMID:26919633

  4. Microarray gene expression analysis of fixed archival tissue permits molecular classification and identification of potential therapeutic targets in diffuse large B-cell lymphoma.

    PubMed

    Linton, Kim; Howarth, Christopher; Wappett, Mark; Newton, Gillian; Lachel, Cynthia; Iqbal, Javeed; Pepper, Stuart; Byers, Richard; Chan, Wing John; Radford, John

    2012-01-01

    Refractory/relapsed diffuse large B-cell lymphoma (DLBCL) has a poor prognosis. Novel drugs targeting the constitutively activated NF-κB pathway characteristic of ABC-DLBCL are promising, but evaluation depends on accurate activated B cell-like (ABC)/germinal center B cell-like (GCB) molecular classification. This is traditionally performed on gene microarray expression profiles of fresh biopsies, which are not routinely collected, or by immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tissue, which lacks reproducibility and classification accuracy. We explored the possibility of using routine archival FFPE tissue for gene microarray applications. We examined Affymetrix HG U133 Plus 2.0 gene expression profiles from paired archival FFPE and fresh-frozen tissues of 40 ABC/GCB-classified DLBCL cases to compare classification accuracy and test the potential for this approach to aid the discovery of therapeutic targets and disease classifiers in DLBCL. Unsupervised hierarchical clustering of unselected present probe sets distinguished ABC/GCB in FFPE with remarkable accuracy, and a Bayesian classifier correctly assigned 32 of 36 cases with >90% probability. Enrichment for NF-κB genes was appropriately seen in ABC-DLBCL FFPE tissues. The top discriminatory genes expressed in FFPE separated cases with high statistical significance and contained novel biology with potential therapeutic insights, warranting further investigation. These results support a growing understanding that archival FFPE tissues can be used in microarray experiments aimed at molecular classification, prognostic biomarker discovery, and molecular exploration of rare diseases.

  5. Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.

    PubMed

    Gomes, Bruno Costa; Santos, Bruno; Rueff, José; Rodrigues, António Sebastião

    2016-01-01

    Drug resistance remains a burden in cancer treatment. In the past few years molecular genetics brought a new hope with personalized therapy. This individual approach allows the identification of genetic profiles that will respond better to a given treatment and consequently get a better outcome. Recently, physicians received an extra aid with the approval of molecular tools based on gene expression signatures. With these tools, physicians have the capacity to identify the probability of disease recurrence in the first 5 years following diagnosis, a fact that is essential for a more effective adjuvant therapy administration. However, some patients still relapse and acquire drug resistance and aggressive tumors. For that reason, a comprehensive understanding of the molecular players in drug resistance is of extreme importance. MicroRNAs have been described as regulators of various cellular pathways and as predictive and prognostic factors. As broad regulators, microRNAs also interfere with drug metabolism and drug targets. Thus it is of paramount importance to understand which microRNAs are deregulated in breast cancer and try to relate this misexpression with resistance to therapeutics, poor outcomes, and survival. Here, we describe a possible approach to study microRNA expression and respective targets from formalin-fixed, paraffin-embedded (FFPE) breast cancer tissues. FFPE tissues are regularly archived for long periods in pathology departments, and microRNAs are well conserved in these tissues. PMID:26910075

  6. Targeted, high-depth, next-generation sequencing of cancer genes in formalin-fixed, paraffin-embedded and fine-needle aspiration tumor specimens.

    PubMed

    Hadd, Andrew G; Houghton, Jeff; Choudhary, Ashish; Sah, Sachin; Chen, Liangjing; Marko, Adam C; Sanford, Tiffany; Buddavarapu, Kalyan; Krosting, Julie; Garmire, Lana; Wylie, Dennis; Shinde, Rupali; Beaudenon, Sylvie; Alexander, Erik K; Mambo, Elizabeth; Adai, Alex T; Latham, Gary J

    2013-03-01

    Implementation of highly sophisticated technologies, such as next-generation sequencing (NGS), into routine clinical practice requires compatibility with common tumor biopsy types, such as formalin-fixed, paraffin-embedded (FFPE) and fine-needle aspiration specimens, and validation metrics for platforms, controls, and data analysis pipelines. In this study, a two-step PCR enrichment workflow was used to assess 540 known cancer-relevant variants in 16 oncogenes for high-depth sequencing in tumor samples on either mature (Illumina GAIIx) or emerging (Ion Torrent PGM) NGS platforms. The results revealed that the background noise of variant detection was elevated approximately twofold in FFPE compared with cell line DNA. Bioinformatic algorithms were optimized to accommodate this background. Variant calls from 38 residual clinical colorectal cancer FFPE specimens and 10 thyroid fine-needle aspiration specimens were compared across multiple cancer genes, resulting in an accuracy of 96.1% (95% CI, 96.1% to 99.3%) compared with Sanger sequencing, and 99.6% (95% CI, 97.9% to 99.9%) compared with an alternative method with an analytical sensitivity of 1% mutation detection. A total of 45 of 48 samples were concordant between NGS platforms across all matched regions, with the three discordant calls each represented at <10% of reads. Consequently, NGS of targeted oncogenes in real-life tumor specimens using distinct platforms addresses unmet needs for unbiased and highly sensitive mutation detection and can accelerate both basic and clinical cancer research.

  7. A multi correlated sampler of the high resolution acquisition system for high rate fixed target KTeV experiments at Fermilab

    NASA Astrophysics Data System (ADS)

    Sanders, H.; Cheu, E.; Zeleznik, M.; Hansen, S.; Tschirhart, R.

    1993-05-01

    A new facility is being planned at Fermilab for fixed target experiments dealing with CP violation in rate neutral kaon decays; and precision measurements on the "direct" CP-violation parameters e'/ e in the 2 pi decay mode of the neutral kaon system. This new Kaons at the TeVatron(KTeV) beam line is expected to be in operation in 1994. The most important new detector component in the KTeV spectrometer is the precision electromagnetic calorimeter, consisting of bars of Cesium Iodide crystals. The choice has been motivated by its radiation hardness, speed and light output. The size of this detector is 2 meters square and includes over 3200 blocks which are coupled to photomultipliers. We expect a peak anode current pulse of 100 ma from an80 Gev deposit. The pulse shape approximates a signal with a FWHM of 25 nanoseconds, but contains some energy in a long tail that exists for more than 500 nanoseconds. The design for the data acquisition electronics will measure deposited charge in every channel in two 12 bit linear ranges: a low range of 2 MEV per count up to a maximum signal of 82 GEV and a range that will handle signals ten times larger with the same proportion in energy resolution. Since the total required dynamic range of this design is between 15 and 16 bit resolution, the problem of pedestal and pile up is seriously engaged with the configuration of this design.

  8. Application of targeted metagenomics to explore abundance and diversity of CO₂-fixing bacterial community using cbbL gene from the rhizosphere of Arachis hypogaea.

    PubMed

    Yousuf, Basit; Keshri, Jitendra; Mishra, Avinash; Jha, Bhavanath

    2012-09-10

    Sequestration of CO(2) by autotrophic bacteria is a key process of biogeochemical carbon cycling in soil ecosystem. Rhizosphere is a rich niche of microbial activity and diversity, influenced by change in atmospheric CO(2). Structural changes in rhizosphere composition influence microbial communities and the nutrient cycling. In the present study, the bacterial diversity and population dynamics were established using cbbL and 16S rRNA gene targeted metagenomics approach from the rhizosphere of Arachis hypogaea. A total of 108 cbbL clones were obtained from the rhizospheric soil which revealed predominance of cbbL sequences affiliated to Rhizobium leguminosarum, Bradyrhizobium sp., Sinorhizobium meliloti, Ochrobactrum anthropi and a variety of uncultured cbbL harboring bacteria. The 16S rRNA gene clone library exhibited the dominance of Firmicutes (34.4%), Proteobacteria (18.3%), Actinobacteria (17.2%) and Bacteroidetes (16.1%). About 43% nucleotide sequences of 16S rRNA gene clone library were novel genera which showed <95% homology with published sequences. Gene copy number of cbbL and 16S rRNA genes, determined by quantitative real-time PCR (qRT PCR), was 9.38 ± 0.75 × 10(7) and 5.43 ± 0.79 × 10(8) (per g dry soil), respectively. The results exhibited bacterial community structure with high bacterial diversity and abundance of CO(2)-fixing bacteria, which can be explored further for their role in carbon cycling, sustainable agriculture and environment management.

  9. APT target-blanket fabrication development

    SciTech Connect

    Fisher, D.L.

    1997-06-13

    Concepts for producing tritium in an accelerator were translated into hardware for engineering studies of tritium generation, heat transfer, and effects of proton-neutron flux on materials. Small-scale target- blanket assemblies were fabricated and material samples prepared for these performance tests. Blanket assemblies utilize composite aluminum-lead modules, the two primary materials of the blanket. Several approaches are being investigated to produce large-scale assemblies, developing fabrication and assembly methods for their commercial manufacture. Small-scale target-blanket assemblies, designed and fabricated at the Savannah River Site, were place in Los Alamos Neutron Science Center (LANSCE) for irradiation. They were subjected to neutron flux for nine months during 1996-97. Coincident with this test was the development of production methods for large- scale modules. Increasing module size presented challenges that required new methods to be developed for fabrication and assembly. After development, these methods were demonstrated by fabricating and assembling two production-scale modules.

  10. Impact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleonImpact parameter dependence of K+/-, p, pbar, d and dbar production in fixed-target Pb + Pb collisions at 158 GeV/nucleon

    NASA Astrophysics Data System (ADS)

    NA52 Collaboration; Ambrosini, G.; Arsenescu, R.; Baglin, C.; Beringer, J.; Borer, K.; Bussière, A.; Elsener, K.; Gorodetzky, Ph; Guillaud, J. P.; Hess, P.; Kabana, S.; Klingenberg, R.; Lindén, T.; Lohmann, K. D.; Mommsen, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Tuominiemi, J.; Weber, M.

    1999-12-01

    Nuclear matter is expected to undergo a phase transition to quark matter in ultrarelativistic heavy-ion collisions, possibly showing up as a discontinuity in the impact parameter dependence of relevant observables. Following this expectation, we have investigated the impact parameter dependence of the invariant yields of K+/-, p, d, pbar and dbar in the range ~ 2 - 12 fm in fixed-target Pb+Pb collisions at 158 GeV/nucleon incident energy at the CERN SPS. The particles have been measured near zero transverse momentum and in the rapidity range y = 3.1 - 4.4. In addition, the centrality dependence of the baryon chemical potential, the effective temperature and the size of the particle emitting source at freeze-out were studied. No dramatic change in the distribution of any of these variables is observed as a function of the impact parameter. The same is found for the particle yields, with the exception of the yield of charged kaons per number of nucleons participating in the collision (Np), where there is an indication of a threshold behaviour at Np~80.

  11. Measurement of the J/ψ production cross section in 920 GeV/c fixed-target proton nucleus interactions

    NASA Astrophysics Data System (ADS)

    Hera-B Collaboration; Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; de Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; Zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. Aa.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.

    2006-07-01

    The mid-rapidity (dσ/dy at y=0) and total (σ) production cross sections of Jψ mesons are measured in proton nucleus interactions. Data collected by the HERA-B experiment in interactions of 920 GeV/c protons with carbon, titanium and tungsten targets are used for this analysis. The Jψ mesons are reconstructed by their decay into lepton pairs. The total production cross section obtained is σpNJ/ψ=663±74±46 nb/nucleon. In addition, our result is compared with previous measurements.

  12. Measurement of the J / ψ production cross section in 920 GeV / c fixed-target proton-nucleus interactions

    NASA Astrophysics Data System (ADS)

    Abt, I.; Adams, M.; Agari, M.; Albrecht, H.; Aleksandrov, A.; Amaral, V.; Amorim, A.; Aplin, S. J.; Aushev, V.; Bagaturia, Y.; Balagura, V.; Bargiotti, M.; Barsukova, O.; Bastos, J.; Batista, J.; Bauer, C.; Bauer, Th. S.; Belkov, A.; Belkov, Ar.; Belotelov, I.; Bertin, A.; Bobchenko, B.; Böcker, M.; Bogatyrev, A.; Bohm, G.; Bräuer, M.; Bruinsma, M.; Bruschi, M.; Buchholz, P.; Buran, T.; Carvalho, J.; Conde, P.; Cruse, C.; Dam, M.; Danielsen, K. M.; Danilov, M.; De Castro, S.; Deppe, H.; Dong, X.; Dreis, H. B.; Egorytchev, V.; Ehret, K.; Eisele, F.; Emeliyanov, D.; Essenov, S.; Fabbri, L.; Faccioli, P.; Feuerstack-Raible, M.; Flammer, J.; Fominykh, B.; Funcke, M.; Garrido, Ll.; Gellrich, A.; Giacobbe, B.; Gläß, J.; Goloubkov, D.; Golubkov, Y.; Golutvin, A.; Golutvin, I.; Gorbounov, I.; Gorišek, A.; Gouchtchine, O.; Goulart, D. C.; Gradl, S.; Gradl, W.; Grimaldi, F.; Guilitsky, Yu.; Hansen, J. D.; Hernández, J. M.; Hofmann, W.; Hohlmann, M.; Hott, T.; Hulsbergen, W.; Husemann, U.; Igonkina, O.; Ispiryan, M.; Jagla, T.; Jiang, C.; Kapitza, H.; Karabekyan, S.; Karpenko, N.; Keller, S.; Kessler, J.; Khasanov, F.; Kiryushin, Yu.; Kisel, I.; Klinkby, E.; Knöpfle, K. T.; Kolanoski, H.; Korpar, S.; Krauss, C.; Kreuzer, P.; Križan, P.; Krücker, D.; Kupper, S.; Kvaratskheliia, T.; Lanyov, A.; Lau, K.; Lewendel, B.; Lohse, T.; Lomonosov, B.; Männer, R.; Mankel, R.; Masciocchi, S.; Massa, I.; Matchikhilian, I.; Medin, G.; Medinnis, M.; Mevius, M.; Michetti, A.; Mikhailov, Yu.; Mizuk, R.; Muresan, R.; zur Nedden, M.; Negodaev, M.; Nörenberg, M.; Nowak, S.; Núñez Pardo de Vera, M. T.; Ouchrif, M.; Ould-Saada, F.; Padilla, C.; Peralta, D.; Pernack, R.; Pestotnik, R.; Petersen, B. AA.; Piccinini, M.; Pleier, M. A.; Poli, M.; Popov, V.; Pose, D.; Prystupa, S.; Pugatch, V.; Pylypchenko, Y.; Pyrlik, J.; Reeves, K.; Reßing, D.; Rick, H.; Riu, I.; Robmann, P.; Rostovtseva, I.; Rybnikov, V.; Sánchez, F.; Sbrizzi, A.; Schmelling, M.; Schmidt, B.; Schreiner, A.; Schröder, H.; Schwanke, U.; Schwartz, A. J.; Schwarz, A. S.; Schwenninger, B.; Schwingenheuer, B.; Sciacca, F.; Semprini-Cesari, N.; Shuvalov, S.; Silva, L.; Sözüer, L.; Solunin, S.; Somov, A.; Somov, S.; Spengler, J.; Spighi, R.; Spiridonov, A.; Stanovnik, A.; Starič, M.; Stegmann, C.; Subramania, H. S.; Symalla, M.; Tikhomirov, I.; Titov, M.; Tsakov, I.; Uwer, U.; van Eldik, C.; Vassiliev, Yu.; Villa, M.; Vitale, A.; Vukotic, I.; Wahlberg, H.; Walenta, A. H.; Walter, M.; Wang, J. J.; Wegener, D.; Werthenbach, U.; Wolters, H.; Wurth, R.; Wurz, A.; Zaitsev, Yu.; Zavertyaev, M.; Zeuner, T.; Zhelezov, A.; Zheng, Z.; Zimmermann, R.; Živko, T.; Zoccoli, A.; HERA-B Collaboration

    2006-07-01

    The mid-rapidity (dσpN / dy at y = 0) and total (σpN) production cross sections of Jψ mesons are measured in proton-nucleus interactions. Data collected by the HERA-B experiment in interactions of 920 GeV / c protons with carbon, titanium and tungsten targets are used for this analysis. The Jψ mesons are reconstructed by their decay into lepton pairs. The total production cross section obtained is σpNJ / ψ = 663 ± 74 ± 46 nb /nucleon. In addition, our result is compared with previous measurements.

  13. An electron fixed target experiment to search for a new vector boson A' decaying to e+e-

    SciTech Connect

    Rouven Essig; Schuster, Philip; Toro, Natalia; Wojtsekhowski, Bogdan

    2011-02-02

    We describe an experiment to search for a new vector boson A' with weak coupling alpha' > 6 x 10–8 α to electrons (α' = e2/4π) in the mass range 65 MeV < mA' < 550 MeV. New vector bosons with such small couplings arise naturally from a small kinetic mixing of the "dark photon" A' with the photon -- one of the very few ways in which new forces can couple to the Standard Model -- and have received considerable attention as an explanation of various dark matter related anomalies. A' bosons are produced by radiation off an electron beam, and could appear as narrow resonances with small production cross-section in the trident e+e- spectrum. We summarize the experimental approach described in a proposal submitted to Jefferson Laboratory's PAC35, PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory (CEBAF) at energies of ~1-4 GeV incident on 0.5-10% radiation length Tungsten wire mesh targets, and measures the resulting e+e- pairs to search for the A' using the High Resolution Spectrometer and the septum magnet in Hall A. With a ~1 month run, APEX will achieve very good sensitivity because the statistics of e+e- pairs will be ~10,000 times larger in the explored mass range than any previous search for the A' boson. These statistics and the excellent mass resolution of the spectrometers allow sensitivity to α'/α one to three orders of magnitude below current limits, in a region of parameter space of great theoretical and phenomenological interest. Similar experiments could also be performed at other facilities, such as the Mainz Microtron.

  14. Seismic subduction of the Nazca Ridge as shown by the 1996-97 Peru earthquakes

    USGS Publications Warehouse

    Spence, W.; Mendoza, C.; Engdahl, E.R.; Choy, G.L.; Norabuena, E.

    1999-01-01

    By rupturing more than half of the shallow subduction interface of the Nazca Ridge, the great November 12, 1996 Peruvian earthquake contradicts the hypothesis that oceanic ridges subduct aseismically. The mainshock's rupture has a length of about 200 km and has an average slip of about 1.4 m. Its moment is 1.5 x 1028 dyne-cm and the corresponding M(w) is 8.0. The mainshock registered three major episodes of moment release as shown by a finite fault inversion of teleseismically recorded broadband body waves. About 55% of the mainshock's total moment release occurred south of the Nazca Ridge, and the remaining moment release occurred at the southern half of the subduction interface of the Nazca Ridge. The rupture south of the Nazca Ridge was elongated parallel to the ridge axis and extended from a shallow depth to about 65 km depth. Because the axis of the Nazca Ridge is at a high angle to the plate convergence direction, the subducting Nazca Ridge has a large southwards component of motion, 5 cm/yr parallel to the coast. The 900-1200 m relief of the southwards sweeping Nazca Ridge is interpreted to act as a 'rigid indenter,' causing the greatest coupling south of the ridge's leading edge and leading to the large observed slip. The mainshock and aftershock hypocenters were relocated using a new procedure that simultaneously inverts local and teleseismic data. Most aftershocks were within the outline of the Nazca Ridge. A three-month delayed aftershock cluster' occurred at the northern part of the subducting Nazca Ridge. Aftershocks were notably lacking at the zone of greatest moment release, to the south of the Nazca Ridge. However, a lone foreshock at the southern end of this zone, some 140 km downstrike of the mainshock's epicenter, implies that conditions existed for rupture into that zone. The 1996 earthquake ruptured much of the inferred source zone of the M(w) 7.9-8.2 earthquake of 1942, although the latter was a slightly larger earthquake. The rupture zone of the 1996 earthquake is immediately north of the seismic gap left by the great earthquakes (M(w) ~8.8-9.1) of 1868 and 1877. The M(w) 8.0 Antofagasta earthquake of 1995 occurred at the southern end of this great seismic gap. The M(w) 8.2 deep-focus Bolivian earthquake of 1994 occurred directly downdip of the 1868 portion of that gap. The recent occurrence of three significant earthquakes on the periphery of the great seismic gap of the 1868 and 1877 events, among other factors, may signal an increased seismic potential for that zone.

  15. Analysis of U.S. Propane Markets Winter 1996-97, An

    EIA Publications

    1997-01-01

    This study constitutes an examination of propane supply, demand, and price developments and trends. The Energy Information Administration's approach focused on identifying the underlying reasons for the tight supply/demand balance in the fall of 1996, and on examining the potential for a recurrence of these events next year.

  16. Evaluation of the effectiveness of an urban stormwater treatment unit in Madison, Wisconsin, 1996-97

    USGS Publications Warehouse

    Waschbusch, Robert J.

    1999-01-01

    The material retained in the treatment chamber had high concentrations of lead and PAH and may be subject to special disposal restrictions based on those concentrations and the presence of benzo(a)anthracene. The chemical makeup of the retained material in other similar stormwater treatment units will probably vary depending on the land use and activities in the drainage basin.

  17. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area D.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    The Ninth Grade Restructuring Program of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were…

  18. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area B.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    The Ninth Grade Restructuring Program of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were…

  19. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area C.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    This evaluation of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were instructional and direct…

  20. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area F.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    The Ninth Grade Restructuring Program of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were…

  1. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area E.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    The Ninth Grade Restructuring Program of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were…

  2. Evaluation of the 1996-97 Ninth Grade Restructuring Program. Area A.

    ERIC Educational Resources Information Center

    Syropoulos, Mike

    The Ninth Grade Restructuring Program of the Detroit (Michigan) public schools was designed to restructure the ninth grade in ways that improve academic performance, develop positive attitudes toward learning, improve the school environment, reduce the dropout rate, and increase the graduation rate of students. Features of the program were…

  3. Super I: 1996-97 Pilot Program Year-End Report. Publication Number 96.07.

    ERIC Educational Resources Information Center

    Lyons, Andri; Smith, Ralph

    The Substance Use Prevention Education and Resources (SUPER I) program of the Austin Independent School District (Texas) is a school-based middle- and high-school curriculum that is offered as a positive alternative to long-term removals to students who have committed alcohol or drug-related offenses for the first time (excluding the sale or…

  4. Concentrations and loads of nitrogen and phosphorus in the Yazoo River, northwestern Mississippi, 1996-97

    USGS Publications Warehouse

    Coupe, Richard H.

    1998-01-01

    Increased nutrient loading to the Gulf of Mexico from off-continent flux has been identified as contributing to the increase in the areal extent of the low dissolved-oxygen zone that develops annually off the coast of Louisiana and Texas. The proximity of the Yazoo River Basin in northwestern Mississippi to the Gulf of Mexico, and the intensive agriculture in the basin have lead to speculation that the Yazoo River Basin contributes a disproportionate amount of nitrogen and phosphorus to the Mississippi River and ultimately the Gulf of Mexico. Water samples from the Yazoo River were collected during 1996 and 1997 and were analyzed for total nitrogen, nitrate as nitrogen, total phosphorus, and orthophosphorus as part of the U.S. Geological Survey?s National Water-Quality Assessment Program. These data were used to compute annual loads of nitrogen and phosphorus discharged from the Yazoo River for 1996 and 1997. Annual loads of nitrogen and phosphorus were calculated by two methods. The first used multivariate regression and the second multiplied the mean annual concentration by the total annual flow. Load estimates based on the product of the mean annual concentration and the total annual flow were within the 95 percent confidence interval for the load calculated by multivariate regression in all cases. The Yazoo River loads, compared to long-term annual loads in the Mississippi River, indicated that the Yazoo River was contributing 2.3 percent or less of the total nitrogen load, 5.7 percent or less of the total phosphorus load, and 1 percent or less of the nitrate load in 1996 and 1997. The total nitrogen load from the Yazoo River Basin into the Mississippi River and ultimately the Gulf of Mexico was proportional to its discharge, the nitrate load was less than expected, whereas the total phosphorus load was slightly higher than expected based on discharge.

  5. [Ontario Ministry of Environment and Energy]. Annual report 1996--97

    SciTech Connect

    1997-12-31

    Annual report lists initiatives, activities and achievements for the year: Reforming environmental approvals; streamlining environmental legislation; strengthening environmental assessment; changes to the electricity sector; landfill standards; soil cleanup guideline; regulatory reforms; 3-year plan for priority standards; vehicle emissions testing; the fight against smog; greenhouse gas reduction; municipalities get responsibility for water and sewage works; remedial action plans -- RAPs; Ontario`s sport fish; MISA regulations, Municipal-Industrial Strategy for Abatement; pollution prevention partnerships; and EECO `96, Environment and Energy Conference of Ontario. An expenditure statement concludes the document.

  6. Trace ResourceBook: Assistive Technologies for Communication, Control & Computer Access. 1996-97 Edition.

    ERIC Educational Resources Information Center

    Borden, Peter A., Ed.; And Others

    This resource book lists approximately 1,500 products designed specifically for the needs of people with disabilities. Typically, each product is pictured; basic information is provided including manufacturer name, product cost, size, and weight; and the product is briefly described. The book's four sections each describe products designed for…

  7. Lower Red River Meadow Restoration Project : Biennial Report 1996-97.

    SciTech Connect

    LRK Communications; Wildlife Habitat Institute; Pocket Water, Inc.

    2003-07-01

    The Red River has been straightened and the riparian vegetation corridor eliminated in several reaches within the watershed. The river responded by incision resulting in over-steepened banks, increased sedimentation, elevated water temperatures, depressed groundwater levels, reduced floodplain function, and degraded fish habitat. The Lower Red River Meadow Restoration Project is a multi-phase ecosystem enhancement effort that restores natural physical and biological processes and functions to stabilize the stream channel and establish high quality habitats for fish and wildlife. A natural channel restoration philosophy guides the design and on the ground activities, allowing the channel to evolve into a state of dynamic equilibrium. Two years of planning, two years of restoration in Phases I and II, and one year post-restoration monitoring are complete. By excavating new bends and reconnecting historic meanders, Phase I and II channel realignment increased channel length by 3,060 feet, decreased channel gradient by 25 percent, and increased sinuosity from 1.7 to 2.3. Cross-sectional shapes and point bars were modified to maintain deep pool habitat at low flow and to reconnect the meadow floodplain. Improved soil moisture conditions will help sustain the 31,500 native riparian plantings reestablished within these two phases. Overall, short-term restoration performance was successful. Analyses of long-term parameters document either post-restoration baseline conditions or early stages of evolution toward desired conditions. An adaptive management strategy has helped to improve restoration designs, methods, and monitoring. Lessons learned are being transferred to a variety of audiences to advance the knowledge of ecological restoration and wise management of watersheds.

  8. Arizona's School to Work System. Site Visit Reports (1996-97).

    ERIC Educational Resources Information Center

    Vandegrift, Judith A.; Larson, Elizabeth Hunt

    This document profiles the following 13 regional partnerships that together constitute Arizona's school-to-work (STW) system: Cochise STW Partnership; Coconino County STW Partnership; Eastern Arizona STW Partnership; East Valley STW Initiative; Mohave Workforce Development Partnership; Northeast Valley School to Work Consortium; Northland School…

  9. Dissolved pesticides in the Alamo River and the Salton Sea, California, 1996-97

    USGS Publications Warehouse

    Crepeau, Kathryn L.; Kuivila, Kathryn M.; Bergamaschi, Brian A.

    2002-01-01

    Water samples were collected from the Alamo River and the Salton Sea, California, in autumn 1996 and late winter/early spring 1997 and analyzed for dissolved pesticides. The two seasons chosen for sampling were during pesticide application periods in the Imperial Valley. Pesticide concentrations were measured in filtered water samples using solid-phase extraction and analyzed by gas chromatography/mass spectrometry. Generally, the highest concentrations were measured in the Alamo River. The concentrations of carbaryl, chlorpyrifos, cycloate, dacthal, diazinon, and eptam were highest in samples collected in autumn 1996. In contrast, the concentrations of atrazine, carbofuran, and malathion were highest in samples collected in late winter/early spring 1997. The highest concentrations measured of atrazine, carbofuran, dacthal, eptam, and malathion all exceeded 1,000 nanograms per liter.

  10. Tidewater Community College Biennial Transfer Student Report, 1996-97 and 1997-98 Academic Years.

    ERIC Educational Resources Information Center

    Janicki, Heidi

    This report provides an analysis of Tidewater Community College (TCC) (Virginia) students who transferred to a four-year institution in Virginia beginning in fall 1996 or 1997. The following topics are discussed: overview of the transfer process; acceptance and enrollment rates for each of the four-year institutions; performance of TCC graduates…

  11. A Report on Teen Pregnancy in Montana. 1996/97 Montana Special Report No. 2.

    ERIC Educational Resources Information Center

    Healthy Mothers, Healthy Babies--The Montana Coalition, Helena.

    This brief "Kids Count" report explores the impact of and factors that bear on teen pregnancy in Montana and ways to prevent teen pregnancy. Statistics and summaries are provided in the following areas: (1) live births to women under age 20, 1990-95; (2) Montana's unmarried teen births as compared to neighboring states; (3) number of Montana teen…

  12. Streamflow gains and losses in the lower Boise River basin, Idaho, 1996-97

    USGS Publications Warehouse

    Berenbrock, Charles

    1999-01-01

    Study results indicate that additional seepage runs are needed on irrigation canals and creeks, the Boise River, and the New York Canal. Piezometers installed at different depths are needed to better define vertical ground-water movement and gradients. Additional work is needed to determine how seepage in canals and streams relates to environmental characteristics.

  13. Stream monitoring and educational program in the Red River Basin, Texas, 1996-97

    USGS Publications Warehouse

    Baldys, Stanley; Phillips, D. Grant

    1998-01-01

    This fact sheet presents the 1996–97 stream monitoring and outreach activities of the U.S. Geological Survey (USGS), the Red River Authority of Texas, the U.S. Army Corps of Engineers, the City of Wichita Falls, the Wichita County Water Improvement District No. 2, and the Texas Water Development Board. The fact sheet was prepared by the USGS in cooperation with the Red River Authority of Texas.

  14. Bilingual Program Evaluation Report on Idea Language Proficiency Tests, 1996-97.

    ERIC Educational Resources Information Center

    Sarangarm, Isara; And Others

    The report presents findings concerning the language proficiency of elementary, middle, and high school students receiving bilingual services in the Las Cruces Public Schools (New Mexico). The report contains five sections: general information about the bilingual program in the school district; the Idea Language Proficiency Tests (IPT); results of…

  15. ESPN2 Sports Figures Makes Math and Physics a Ball! 1996-97 Educator's Curriculum.

    ERIC Educational Resources Information Center

    Rusczyk, Richard; Lehoczky, Sandor

    This guide is designed to accompany ESPN's SportsFigures video segments which were created to enhance the interest and learning progress of high school students in mathematics, physics, and physical science. Using actual, re-enacted, or staged events, the problems presented in each of the 16 Sports Figures segments illustrate the relationship…

  16. [Advantages of fixed combinations].

    PubMed

    Lachkar, Y

    2008-07-01

    Fixed combinations are indicated in the treatment of glaucoma and ocular hypertension when monotherapy does not sufficiently reduce IOP. Fixed combinations show better efficacy than the instillation of each separate component and are at least equivalent to the administration of both components in a separate association. They simplify treatment, increase compliance and quality of life, and decrease exposure to preservatives. Although they are less aggressive for patients when a new drug needs to be added, the use of fixed combinations should not decrease the follow-up. PMID:18957922

  17. Fixed Exit Monochromator with fixed Rotation Axis

    SciTech Connect

    Caliebe, W.A.; Cheung, S.; Lenhard, A.; Siddons, D.P.

    2004-05-12

    A new simple design for a fixed-exit monochromator has been developed. The set-up uses a linear slide to couple the rotation of the crystals to a translation of the second one to compensate for the 2hcos{theta} dependence of the beam-offset in a double crystal monochromator. This set-up requires just one motor for the rotation of the monochromator, and three piezo-actuators to tune the second crystal.The monochromator has been tested for Bragg-angles between 7 deg. and 70 deg.

  18. Why to Treat Subjects as Fixed Effects

    ERIC Educational Resources Information Center

    Adelman, James S.; Estes, Zachary

    2015-01-01

    Adelman, Marquis, Sabatos-DeVito, and Estes (2013) collected word naming latencies from 4 participants who read 2,820 words 50 times each. Their recommendation and practice was that R2 targets set for models should take into account subject idiosyncrasies as replicable patterns, equivalent to a subjects-as-fixed-effects assumption. In light of an…

  19. Fixing Dataset Search

    NASA Technical Reports Server (NTRS)

    Lynnes, Chris

    2014-01-01

    Three current search engines are queried for ozone data at the GES DISC. The results range from sub-optimal to counter-intuitive. We propose a method to fix dataset search by implementing a robust relevancy ranking scheme. The relevancy ranking scheme is based on several heuristics culled from more than 20 years of helping users select datasets.

  20. Fixed mount wavefront sensor

    DOEpatents

    Neal, Daniel R.

    2000-01-01

    A rigid mount and method of mounting for a wavefront sensor. A wavefront dissector, such as a lenslet array, is rigidly mounted at a fixed distance relative to an imager, such as a CCD camera, without need for a relay imaging lens therebetween.

  1. Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

    PubMed

    Tuononen, Katja; Mäki-Nevala, Satu; Sarhadi, Virinder Kaur; Wirtanen, Aino; Rönty, Mikko; Salmenkivi, Kaisa; Andrews, Jenny M; Telaranta-Keerie, Aino I; Hannula, Sari; Lagström, Sonja; Ellonen, Pekka; Knuuttila, Aija; Knuutila, Sakari

    2013-05-01

    The development of tyrosine kinase inhibitor treatments has made it important to test cancer patients for clinically significant gene mutations that influence the benefit of treatment. Targeted next-generation sequencing (NGS) provides a promising method for diagnostic purposes by enabling the simultaneous detection of multiple mutations in various genes in a single test. The aim of our study was to screen EGFR, KRAS, and BRAF mutations by targeted NGS and commonly used real-time polymerase chain reaction (PCR) methods to evaluate the feasibility of targeted NGS for the detection of the mutations. Furthermore, we aimed to identify potential novel mutations by targeted NGS. We analyzed formalin-fixed, paraffin-embedded (FFPE) tumor tissue specimens from 81 non-small cell lung carcinoma patients. We observed a significant concordance (from 96.3 to 100%) of the EGFR, KRAS, and BRAF mutation detection results between targeted NGS and real-time PCR. Moreover, targeted NGS revealed seven nonsynonymous single-nucleotide variations and one insertion-deletion variation in EGFR not detectable by the real-time PCR methods. The potential clinical significance of these variants requires elucidation in future studies. Our results support the use of targeted NGS in the screening of EGFR, KRAS, and BRAF mutations in FFPE tissue material.

  2. Fixed sagittal plane imbalance.

    PubMed

    Savage, Jason W; Patel, Alpesh A

    2014-12-01

    Study Design Literature review. Objective To discuss the evaluation and management of fixed sagittal plane imbalance. Methods A comprehensive literature review was performed on the preoperative evaluation of patients with sagittal plane malalignment, as well as the surgical strategies to address sagittal plane deformity. Results Sagittal plane imbalance is often caused by de novo scoliosis or iatrogenic flat back deformity. Understanding the etiology and magnitude of sagittal malalignment is crucial in realignment planning. Objective parameters have been developed to guide surgeons in determining how much correction is needed to achieve favorable outcomes. Currently, the goals of surgery are to restore a sagittal vertical axis < 5 cm, pelvic tilt < 20 degrees, and lumbar lordosis equal to pelvic incidence ± 9 degrees. Conclusion Sagittal plane malalignment is an increasingly recognized cause of pain and disability. Treatment of sagittal plane imbalance varies according to the etiology, location, and severity of the deformity. Fixed sagittal malalignment often requires complex reconstructive procedures that include osteotomy correction. Reestablishing harmonious spinopelvic alignment is associated with significant improvement in health-related quality-of-life outcome measures and patient satisfaction.

  3. Fixed and Sunk Costs Revisited.

    ERIC Educational Resources Information Center

    Wang, X. Henry; Yang, Bill Z.

    2001-01-01

    Attempts to clarify the concepts of, and the link between, fixed costs and sunk costs. Argues that the root of confusion is the inconsistency in defining the term fixed costs. Consistently defines fixed and sunk costs, and describes how instructors must teach under these definitions. (RLH)

  4. Apparatus for fixing latency

    DOEpatents

    Hall, David R.; Bartholomew, David B.; Moon, Justin; Koehler, Roger O.

    2009-09-08

    An apparatus for fixing computational latency within a deterministic region on a network comprises a network interface modem, a high priority module and at least one deterministic peripheral device. The network interface modem is in communication with the network. The high priority module is in communication with the network interface modem. The at least one deterministic peripheral device is connected to the high priority module. The high priority module comprises a packet assembler/disassembler, and hardware for performing at least one operation. Also disclosed is an apparatus for executing at least one instruction on a downhole device within a deterministic region, the apparatus comprising a control device, a downhole network, and a downhole device. The control device is near the surface of a downhole tool string. The downhole network is integrated into the tool string. The downhole device is in communication with the downhole network.

  5. [Fixed-dose combination].

    PubMed

    Nagai, Yoshio

    2015-03-01

    Many patients with type 2 diabetes mellitus(T2DM) do not achieve satisfactory glycemic control by monotherapy alone, and often require multiple oral hypoglycemic agents (OHAs). Combining OHAs with complementary mechanisms of action is fundamental to the management of T2DM. Fixed-dose combination therapy(FDC) offers a method of simplifying complex regimens. Efficacy and tolerability appear to be similar between FDC and treatment with individual agents. In addition, FDC can enhance adherence and improved adherence may result in improved glycemic control. Four FDC agents are available in Japan: pioglitazone-glimepiride, pioglitazone-metformin, pioglitazone-alogliptin, and voglibose-mitiglinide. In this review, the advantages and disadvantages of these four combinations are identified and discussed. PMID:25812374

  6. Fixed Access Network Sharing

    NASA Astrophysics Data System (ADS)

    Cornaglia, Bruno; Young, Gavin; Marchetta, Antonio

    2015-12-01

    Fixed broadband network deployments are moving inexorably to the use of Next Generation Access (NGA) technologies and architectures. These NGA deployments involve building fiber infrastructure increasingly closer to the customer in order to increase the proportion of fiber on the customer's access connection (Fibre-To-The-Home/Building/Door/Cabinet… i.e. FTTx). This increases the speed of services that can be sold and will be increasingly required to meet the demands of new generations of video services as we evolve from HDTV to "Ultra-HD TV" with 4k and 8k lines of video resolution. However, building fiber access networks is a costly endeavor. It requires significant capital in order to cover any significant geographic coverage. Hence many companies are forming partnerships and joint-ventures in order to share the NGA network construction costs. One form of such a partnership involves two companies agreeing to each build to cover a certain geographic area and then "cross-selling" NGA products to each other in order to access customers within their partner's footprint (NGA coverage area). This is tantamount to a bi-lateral wholesale partnership. The concept of Fixed Access Network Sharing (FANS) is to address the possibility of sharing infrastructure with a high degree of flexibility for all network operators involved. By providing greater configuration control over the NGA network infrastructure, the service provider has a greater ability to define the network and hence to define their product capabilities at the active layer. This gives the service provider partners greater product development autonomy plus the ability to differentiate from each other at the active network layer.

  7. Targeting of a Fixed Bacterial Immunogen to Fc Receptors Reverses the Anti-Inflammatory Properties of the Gram-Negative Bacterium, Francisella tularensis, during the Early Stages of Infection

    PubMed Central

    Babadjanova, Zulfia; Wiedinger, Kari; Gosselin, Edmund J.; Bitsaktsis, Constantine

    2015-01-01

    Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including Francisella tularensis, the agent of tularemia, utilize the anti-inflammatory cytokine IL-10, to evade the host immune response. It is well established that IL-10 has the ability to inhibit robust antigen presentation by dendritic cells and macrophages, thus suppressing the generation of protective immunity. The pathogenesis of F. tularensis is not fully understood, and research has failed to develop an effective vaccine to this date. In the current study, we hypothesized that F. tularensis polarizes antigen presenting cells during the early stages of infection towards an anti-inflammatory status characterized by increased synthesis of IL-10 and decreased production of IL-12p70 and TNF-α in an IFN-ɣ-dependent fashion. In addition, F. tularensis drives an alternative activation of alveolar macrophages within the first 48 hours post-infection, thus allowing the bacterium to avoid protective immunity. Furthermore, we demonstrate that targeting inactivated F. tularensis (iFt) to Fcγ receptors (FcɣRs) via intranasal immunization with mAb-iFt complexes, a proven vaccine strategy in our laboratories, reverses the anti-inflammatory effects of the bacterium on macrophages by down-regulating production of IL-10. More specifically, we observed that targeting of iFt to FcγRs enhances the classical activation of macrophages not only within the respiratory mucosa, but also systemically, at the early stages of infection. These results provide important insight for further understanding the protective immune mechanisms generated when targeting immunogens to Fc receptors. PMID:26114641

  8. Why to treat subjects as fixed effects.

    PubMed

    Adelman, James S; Estes, Zachary

    2015-09-01

    Adelman, Marquis, Sabatos-DeVito, and Estes (2013) collected word naming latencies from 4 participants who read 2,820 words 50 times each. Their recommendation and practice was that R² targets set for models should take into account subject idiosyncrasies as replicable patterns, equivalent to a subjects-as-fixed-effects assumption. In light of an interaction involving subjects, they broke down the interaction into individual subject data. Courrieu and Rey's (2015) commentary argues that (a) single-subject data need not be more reliable than subject-average data, and (b) anyway, treating groups of subjects as random samples leads to valid conclusions about general mechanisms of reading. Point (a) was not part of Adelman et al.'s claim. In this reply, we examine the consequences of using the fixed-effect assumption. It (a) produces the correct target to check if by-items regression models contain all necessary variables, (b) more accurately constrains cognitive models, (c) more accurately reveals general mechanisms, and (d) can offer more powerful tests of effects. Even when individual differences are not the primary focus of a study, the fixed-effect analysis is often preferable to the random-effects analysis. PMID:26348203

  9. Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

    PubMed

    Kell, Douglas B

    2013-12-01

    Despite the sequencing of the human genome, the rate of innovative and successful drug discovery in the pharmaceutical industry has continued to decrease. Leaving aside regulatory matters, the fundamental and interlinked intellectual issues proposed to be largely responsible for this are: (a) the move from 'function-first' to 'target-first' methods of screening and drug discovery; (b) the belief that successful drugs should and do interact solely with single, individual targets, despite natural evolution's selection for biochemical networks that are robust to individual parameter changes; (c) an over-reliance on the rule-of-5 to constrain biophysical and chemical properties of drug libraries; (d) the general abandoning of natural products that do not obey the rule-of-5; (e) an incorrect belief that drugs diffuse passively into (and presumably out of) cells across the bilayers portions of membranes, according to their lipophilicity; (f) a widespread failure to recognize the overwhelmingly important role of proteinaceous transporters, as well as their expression profiles, in determining drug distribution in and between different tissues and individual patients; and (g) the general failure to use engineering principles to model biology in parallel with performing 'wet' experiments, such that 'what if?' experiments can be performed in silico to assess the likely success of any strategy. These facts/ideas are illustrated with a reasonably extensive literature review. Success in turning round drug discovery consequently requires: (a) decent systems biology models of human biochemical networks; (b) the use of these (iteratively with experiments) to model how drugs need to interact with multiple targets to have substantive effects on the phenotype; (c) the adoption of polypharmacology and/or cocktails of drugs as a desirable goal in itself; (d) the incorporation of drug transporters into systems biology models, en route to full and multiscale systems biology models that

  10. Fixed points of quantum gravity.

    PubMed

    Litim, Daniel F

    2004-05-21

    Euclidean quantum gravity is studied with renormalization group methods. Analytical results for a nontrivial ultraviolet fixed point are found for arbitrary dimensions and gauge fixing parameters in the Einstein-Hilbert truncation. Implications for quantum gravity in four dimensions are discussed.

  11. N-terminal processing of membrane-targeted MnSOD and formation of multiple active superoxide dismutase dimers in the nitrogen-fixing cyanobacterium Anabaena sp. strain PCC7120.

    PubMed

    Raghavan, Prashanth S; Rajaram, Hema; Apte, Shree K

    2013-10-01

    Anabaena sp. strain PCC7120 expresses a 30 kDa manganese-dependent superoxide dismutase (MnSOD) comprising a hydrophobic region (signal peptide + linker peptide) attached to a catalytic unit. Bioinformatics predicted cleavage of the signal peptide at (25)CQPQ by signal peptidase and of the linker peptide by an Arg-C-like protease at the Arg52/Arg59 residue. The three predicted forms of MnSOD were immunodetected in Anabaena, with the 30 kDa MnSOD found exclusively in the membrane and the shorter 27 and 24 kDa forms found both in the membrane and soluble fractions. The corresponding sodA gene was truncated for (a) the first eight residues, or, (b) the signal peptide, or (c) the entire hydrophobic region, or (d) the Arg52/Arg59 residues were modified to serine. Overexpression of these MnSOD variants in recombinant Anabaena strains revealed that (a) the 30 kDa membrane-targeted MnSOD was cleaved by membrane-localized signal peptidase either during or after its transport through the membrane to release the 27 kDa form, either in the cytosol or in the periplasmic/thylakoid lumen, (b) the 27 kDa form was further cleaved to the 24 kDa form by Arg-C-like protease, both in the cytosol and in the periplasmic/thylakoid lumen, (c) deletion of signal peptide localized the MnSOD forms in the cytosol, and (d) alteration of the signal/linker peptide cleavage sites interfered with MnSOD localization and processing. Homo/heterodimerization of the 24 and 27 kDa forms of MnSOD and the cytosolic iron-dependent SOD results in multiple SOD activities, from a single MnSOD gene (sodA), in different cellular compartments of Anabaena.

  12. Simulation of Temperature, Nutrients, Biochemical Oxygen Demand, and Dissolved Oxygen in the Catawba River, South Carolina, 1996-97

    USGS Publications Warehouse

    Feaster, Toby D.; Conrads, Paul A.; Guimaraes, Wladmir B.; Sanders, Curtis L.; Bales, Jerad D.

    2003-01-01

    Time-series plots of dissolved-oxygen concentrations were determined for various simulated hydrologic and point-source loading conditions along a free-flowing section of the Catawba River from Lake Wylie Dam to the headwaters of Fishing Creek Reservoir in South Carolina. The U.S. Geological Survey one-dimensional dynamic-flow model, BRANCH, was used to simulate hydrodynamic data for the Branched Lagrangian Transport Model. Waterquality data were used to calibrate the Branched Lagrangian Transport Model and included concentrations of nutrients, chlorophyll a, and biochemical oxygen demand in water samples collected during two synoptic sampling surveys at 10 sites along the main stem of the Catawba River and at 3 tributaries; and continuous water temperature and dissolved-oxygen concentrations measured at 5 locations along the main stem of the Catawba River. A sensitivity analysis of the simulated dissolved-oxygen concentrations to model coefficients and data inputs indicated that the simulated dissolved-oxygen concentrations were most sensitive to watertemperature boundary data due to the effect of temperature on reaction kinetics and the solubility of dissolved oxygen. Of the model coefficients, the simulated dissolved-oxygen concentration was most sensitive to the biological oxidation rate of nitrite to nitrate. To demonstrate the utility of the Branched Lagrangian Transport Model for the Catawba River, the model was used to simulate several water-quality scenarios to evaluate the effect on the 24-hour mean dissolved-oxygen concentrations at selected sites for August 24, 1996, as simulated during the model calibration period of August 23 27, 1996. The first scenario included three loading conditions of the major effluent discharges along the main stem of the Catawba River (1) current load (as sampled in August 1996); (2) no load (all point-source loads were removed from the main stem of the Catawba River; loads from the main tributaries were not removed); and (3) fully loaded (in accordance with South Carolina Department of Health and Environmental Control National Discharge Elimination System permits). Results indicate that the 24-hour mean and minimum dissolved-oxygen concentrations for August 24, 1996, changed from the no-load condition within a range of - 0.33 to 0.02 milligram per liter and - 0.48 to 0.00 milligram per liter, respectively. Fully permitted loading conditions changed the 24-hour mean and minimum dissolved-oxygen concentrations from - 0.88 to 0.04 milligram per liter and - 1.04 to 0.00 milligram per liter, respectively. A second scenario included the addition of a point-source discharge of 25 million gallons per day to the August 1996 calibration conditions. The discharge was added at S.C. Highway 5 or at a location near Culp Island (about 4 miles downstream from S.C. Highway 5) and had no significant effect on the daily mean and minimum dissolved-oxygen concentration. A third scenario evaluated the phosphorus loading into Fishing Creek Reservoir; four loading conditions of phosphorus into Catawba River were simulated. The four conditions included fully permitted and actual loading conditions, removal of all point sources from the Catawba River, and removal of all point and nonpoint sources from Sugar Creek. Removing the point-source inputs on the Catawba River and the point and nonpoint sources in Sugar Creek reduced the organic phosphorus and orthophosphate loadings to Fishing Creek Reservoir by 78 and 85 percent, respectively.

  13. Water quality in the southern Everglades and Big Cypress Swamp in the vicinity of the Tamiami Trail, 1996-97

    USGS Publications Warehouse

    Miller, Ronald L.; McPherson, Benjamin F.; Haag, Kim H.

    1999-01-01

    The quality of water flowing southward in the Everglades and Big Cypress Swamp was characterized by three synoptic surveys along an 80-mile section of the Tamiami Trail and along a 24-mile transect down the Shark River Slough, by monthly sampling of a background reference site in the central Big Cypress Swamp, and by sampling of fish tissue for contaminants at several sites near the Trail. The quality of water along the Trail is spatially variable due to natural and human influences. Concentrations of dissolved solids and common ions such as chloride and sulfate were lowest in the central and eastern Big Cypress Swamp and were higher to the west due to the effects of seawater, especially during the dry season, and to the east due to canal drainage from the northern Everglades. Concentrations of total phosphorus tended to decrease from west to east along the 80-mile section of the Trail, and were usually about 0.01 milligram per liter or less in the Everglades. Short-term loads (based on average discharge for 4 days) of total phosphorus and total Kjeldahl nitrogen (ammonia plus organic nitrogen) across four gaged sections of the Tamiami Trail were highest in the Everglades near the S-12 structures primarily due to the relatively greater discharges in that section. Concentrations of dissolved solids and total phosphorus at the central Big Cypress Swamp site increased significantly during the dry season as waters ponded. Effects of nearby, upstream agricultural activities were evident at a site in the western Big Cypress Swamp where relatively high concentrations of total phosphorus, total mercury, and dissolved organic carbon and high periphyton biomass accumulation rates were measured and where several pesticides were detected. The most frequently detected pesticides along the Trail were atrazine (14 detections), tebuthiuron (11 detections), and metolachlor (5 detections), and most concentrations were less than 0.1 microgram per liter. DDT compounds were the only pesticides detected in fish from five sites. Total DDT ranged from 5 to 6 micrograms per kilogram in largemouth bass and from 11 to 17 micrograms per kilogram in Florida gar.

  14. Secondary School Science Minority Achievement Registry. Volume I. S3MAR Program Directory 1996-97. Project 3000 by 2000.

    ERIC Educational Resources Information Center

    Ang, Tina, Ed.

    The Association of American Medical Colleges launched Project 3000 by 2000 in November 1991 to address the under-representation of Blacks, American Indians, Mexican Americans, and Mainland Puerto Ricans in medical schools. Its aim is to increase the number of under-represented minorities entering medical schools to 3,000 by the year 2000. As part…

  15. Assessment of selected water-quality and biological data collected in the Wichita River basin, Texas, 1996-97

    USGS Publications Warehouse

    Baldys, Stanley; Phillips, D. Grant

    2000-01-01

    The Wichita River Basin in northwest Texas (fig. 1) covers about 3,440 square miles (mi2 ) of the 94,500-mi2 Red River Basin. The drainage area above Lake Kemp (fig. 1) is 2,086 mi2. The Wichita River Basin is characterized by rolling plains and prairie with an average annual (1961–90) rainfall of 28.9 inches at Wichita Falls (population about 100,000), the largest city in the basin (Ramos, 1997). Cattle grazing and agriculture are predominant industries outside the Wichita Falls city limits. One of the earliest oil fields in Texas, the Electra oil field, is in the basin; although some oil is still being produced, oil field activity has decreased from the boom years of the 1920s–30s. The surfacewater supply in this basin generally is of poor quality—dissolved solids concentrations vary from slightly saline (1,000 to 3,000 milligrams per liter (mg/L)) to very saline (10,000 to 35,000 mg/L).

  16. Direct Loan Evaluation. Assessment of Department of Education Administration: Academic Years 1995-96 and 1996-97. Summary Report.

    ERIC Educational Resources Information Center

    Macro International, Inc., Calverton, MD.

    As part of a 5-year evaluation of the William D. Ford Federal Direct Loan Program, this study assessed the U.S. Department of Education's (ED) administration of the program. Data were obtained through interviews with ED and other federal officials, institutional surveys, reviews of documents, attendance at meetings and training events, facilitated…

  17. A Comparison Simulation of Fixed-fixed Type MEMS Switches

    NASA Astrophysics Data System (ADS)

    Rezazadeh, G.; Sadeghian, H.; Malekpour, E.

    2006-04-01

    In the present work pull-in voltage of fixed-fixed end type MEMS switches with variative electrostatic area has been calculated using a distributed model and applying a full nonlinear finite difference discretizing method. The governing nonlinear differential equation has been derived using of the variational principle for multi domain electromechanical coupled system. The numerical results of the beam with variative electrostatic area with the results of Coupled-Domain Finite Element method have been compared and very good agreement has been achieved.

  18. Bar coded retroreflective target

    SciTech Connect

    Vann, C.S.

    2000-01-25

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  19. Bar coded retroreflective target

    DOEpatents

    Vann, Charles S.

    2000-01-01

    This small, inexpensive, non-contact laser sensor can detect the location of a retroreflective target in a relatively large volume and up to six degrees of position. The tracker's laser beam is formed into a plane of light which is swept across the space of interest. When the beam illuminates the retroreflector, some of the light returns to the tracker. The intensity, angle, and time of the return beam is measured to calculate the three dimensional location of the target. With three retroreflectors on the target, the locations of three points on the target are measured, enabling the calculation of all six degrees of target position. Until now, devices for three-dimensional tracking of objects in a large volume have been heavy, large, and very expensive. Because of the simplicity and unique characteristics of this tracker, it is capable of three-dimensional tracking of one to several objects in a large volume, yet it is compact, light-weight, and relatively inexpensive. Alternatively, a tracker produces a diverging laser beam which is directed towards a fixed position, and senses when a retroreflective target enters the fixed field of view. An optically bar coded target can be read by the tracker to provide information about the target. The target can be formed of a ball lens with a bar code on one end. As the target moves through the field, the ball lens causes the laser beam to scan across the bar code.

  20. Evidence of the big fix

    NASA Astrophysics Data System (ADS)

    Hamada, Yuta; Kawai, Hikaru; Kawana, Kiyoharu

    2014-06-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value vh. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self-coupling are fixed when we vary vh. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental law in our case.

  1. Full and partial gauge fixing

    SciTech Connect

    Shirzad, A.

    2007-08-15

    Gauge fixing may be done in different ways. We show that using the chain structure to describe a constrained system enables us to use either a full gauge, in which all gauged degrees of freedom are determined, or a partial gauge, in which some first class constraints remain as subsidiary conditions to be imposed on the solutions of the equations of motion. We also show that the number of constants of motion depends on the level in a constraint chain in which the gauge fixing condition is imposed. The relativistic point particle, electromagnetism, and the Polyakov string are discussed as examples and full or partial gauges are distinguished.

  2. Fixed Costs and Hours Constraints

    ERIC Educational Resources Information Center

    Johnson, William R.

    2011-01-01

    Hours constraints are typically identified by worker responses to questions asking whether they would prefer a job with more hours and more pay or fewer hours and less pay. Because jobs with different hours but the same rate of pay may be infeasible when there are fixed costs of employment or mandatory overtime premia, the constraint in those…

  3. Fixed memory least squares filtering

    NASA Technical Reports Server (NTRS)

    Bierman, G. J.

    1975-01-01

    Buxbaum has reported on three algorithms for computing least squares estimates that are based on fixed amounts of data. In this correspondence, the filter is arranged as a point-deleting Kalman filter concatenated with the standard point-inclusion Kalman filter. The resulting algorithm is couched in a square root framework for greater numerical stability, and special attention is given to computer implementation.

  4. 29 CFR 1917.120 - Fixed stairways.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Fixed stairways. 1917.120 Section 1917.120 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.120 Fixed stairways. (a) Definition. “Fixed stairway... intergral part of machinery. (b) New installations. (1) Fixed stairs installed after October 3, 1983...

  5. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fixed ballast. 170.235 Section 170.235 Shipping COAST... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used, must... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved...

  6. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fixed ballast. 170.235 Section 170.235 Shipping COAST... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used, must... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved...

  7. 29 CFR 1917.120 - Fixed stairways.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Fixed stairways. 1917.120 Section 1917.120 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.120 Fixed stairways. (a) Definition. “Fixed stairway... intergral part of machinery. (b) New installations. (1) Fixed stairs installed after October 3, 1983...

  8. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fixed ballast. 170.235 Section 170.235 Shipping COAST... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used, must... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved...

  9. 29 CFR 1917.120 - Fixed stairways.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Fixed stairways. 1917.120 Section 1917.120 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.120 Fixed stairways. (a) Definition. “Fixed stairway... intergral part of machinery. (b) New installations. (1) Fixed stairs installed after October 3, 1983...

  10. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fixed ballast. 170.235 Section 170.235 Shipping COAST... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used, must... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved...

  11. 29 CFR 1917.120 - Fixed stairways.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Fixed stairways. 1917.120 Section 1917.120 Labor... (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.120 Fixed stairways. (a) Definition. “Fixed stairway... intergral part of machinery. (b) New installations. (1) Fixed stairs installed after October 3, 1983...

  12. 46 CFR 170.235 - Fixed ballast.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fixed ballast. 170.235 Section 170.235 Shipping COAST... ALL INSPECTED VESSELS Special Installations § 170.235 Fixed ballast. (a) Fixed ballast, if used, must... shifting of position. (b) Fixed ballast may not be removed from a vessel or relocated unless approved...

  13. Variable delivery, fixed displacement pump

    DOEpatents

    Sommars, Mark F.

    2001-01-01

    A variable delivery, fixed displacement pump comprises a plurality of pistons reciprocated within corresponding cylinders in a cylinder block. The pistons are reciprocated by rotation of a fixed angle swash plate connected to the pistons. The pistons and cylinders cooperate to define a plurality of fluid compression chambers each have a delivery outlet. A vent port is provided from each fluid compression chamber to vent fluid therefrom during at least a portion of the reciprocal stroke of the piston. Each piston and cylinder combination cooperates to close the associated vent port during another portion of the reciprocal stroke so that fluid is then pumped through the associated delivery outlet. The delivery rate of the pump is varied by adjusting the axial position of the swash plate relative to the cylinder block, which varies the duration of the piston stroke during which the vent port is closed.

  14. KTeV results: Re(e'/e) and rare decay results

    SciTech Connect

    Juliana Whitmore

    2002-10-07

    The KTeV physics program encompasses many goals including a precision measurement of the direct CP violation parameter Re({epsilon}{prime}/{epsilon}) in K{sub S,L} {yields} {pi}{pi} decays, and studies of rare neutral kaon decays. The KTeV detector collected data during the Fermilab fixed-target runs of 1996-97 and 1999. This article focuses on the precision measurement of the direct CP violation parameter Re({epsilon}{prime}/{epsilon}) using the 1996-97 data set. In addition, measurements of the neutral kaon parameters {tau}{sub s}, {Delta}m, {phi}{sub {+-}}, {Delta}{phi} from that data set and a new measurement of the branching fraction of K{sub L} {yields} e{sup +}e{sup -} {mu}{sup +}{mu}{sup -} from the 1997 and 1999 data also are presented.

  15. Wake Shield Target Protection

    SciTech Connect

    Valmianski, Emanuil I.; Petzoldt, Ronald W.; Alexander, Neil B.

    2003-05-15

    The heat flux from both gas convection and chamber radiation on a direct drive target must be limited to avoid target damage from excessive D-T temperature increase. One of the possibilities of protecting the target is a wake shield flying in front of the target. A shield will also reduce drag force on the target, thereby facilitating target tracking and position prediction. A Direct Simulation Monte Carlo (DSMC) code was used to calculate convection heat loads as boundary conditions input into ANSYS thermal calculations. These were used for studying the quality of target protection depending on various shapes of shields, target-shield distance, and protective properties of the shield moving relative to the target. The results show that the shield can reduce the convective heat flux by a factor of 2 to 5 depending on pressure, temperature, and velocity. The protective effect of a shield moving relative to the target is greater than the protective properties of a fixed shield. However, the protective effect of a shield moving under the drag force is not sufficient for bringing the heat load on the target down to the necessary limit. Some other ways of diminishing heat flux using a protective shield are discussed.

  16. Widespread bullous fixed drug eruption

    PubMed Central

    Patell, Rushad D; Dosi, Rupal V; Shah, Purav C; Joshi, Harshal S

    2014-01-01

    A 53-year-old man developed a widespread erythematous eruption which rapidly evolved into fluid-filled bulla mostly involving the distal areas of all four limbs and erosions on the oral as well as anogenital mucosa. Based on clinical presentation, chronology of drug exposure, past events and histopathology as diagnosis of widespread bullous fixed drug eruption was made over Steven Johnson-toxic epidermal necrolysis syndrome. Steroids were deferred and the lesions healed with minimal pigmentation within a week. Differentiating between the two entities has been historically difficult, and yet can have significant therapeutic and prognostic implications. PMID:24510691

  17. Widespread bullous fixed drug eruption.

    PubMed

    Patell, Rushad D; Dosi, Rupal V; Shah, Purav C; Joshi, Harshal S

    2014-02-07

    A 53-year-old man developed a widespread erythematous eruption which rapidly evolved into fluid-filled bulla mostly involving the distal areas of all four limbs and erosions on the oral as well as anogenital mucosa. Based on clinical presentation, chronology of drug exposure, past events and histopathology as diagnosis of widespread bullous fixed drug eruption was made over Steven Johnson-toxic epidermal necrolysis syndrome. Steroids were deferred and the lesions healed with minimal pigmentation within a week. Differentiating between the two entities has been historically difficult, and yet can have significant therapeutic and prognostic implications.

  18. Adaptive MFR parameter control: fixed vs. variable probabilities of detection

    NASA Astrophysics Data System (ADS)

    Boers, Yvo; Driessen, Hans; Zwaga, Jitse

    2005-09-01

    In this paper an efficient adaptive parameter control scheme for Multi Function Radar (MFR) is used. This scheme has been introduced in.5 The scheme has been designed in such a way that it meets constraints on specific quantities that are relevant for target tracking while minimizing the energy spent. It is shown here, that this optimal scheme leads to a considerable variation of the realized detection probability, even within a single scenario. We also show that constraining or fixing the probability of detection to a certain predefined value leads to a considerable increase in the energy spent on the target. This holds even when one optimizes the fixed probability of detection. The bottom line message is that the detection probability is not a design parameter by itself, but merely the product of an optimal schedule.

  19. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Fixed ladders. 1917.118 Section 1917.118 Labor Regulations...) MARINE TERMINALS Terminal Facilities § 1917.118 Fixed ladders. (a) Scope and applicability. This section applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars,...

  20. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Fixed ladders. 1910.27 Section 1910.27 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.27 Fixed ladders. (a) Design... those specified in § 1910.25. All wood parts of fixed ladders shall meet the requirements of §...

  1. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Fixed ladders. 1910.27 Section 1910.27 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.27 Fixed ladders. (a) Design... those specified in § 1910.25. All wood parts of fixed ladders shall meet the requirements of §...

  2. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Fixed ladders. 1910.27 Section 1910.27 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.27 Fixed ladders. (a) Design... those specified in § 1910.25. All wood parts of fixed ladders shall meet the requirements of §...

  3. Removal of well-fixed fixed femoral stems.

    PubMed

    Laffosse, J-M

    2016-02-01

    The removal of a well-fixed prosthetic stem raises technical challenges. The objective is not only to remove the material, but also to prepare the implantation of a new prosthesis. Cemented stems are only very rarely unremovable; extraction of the cement mantle and plug raises the greatest difficulties. The main risk is cortex perforation, and a radiograph should be obtained at the slightest doubt. The removal of cementless stems carries a higher risk of fracture. Difficulties should be anticipated based on thorough familiarity with the implant design and on evaluations of implant fixation and bone stock. The intramedullary approach is usually sufficient to extract a cemented or cementless, well fixed, standard stem. Routine use of a transfemoral approach is warranted only in the following situations: revision surgery for infection, S-shaped stem, long stem, curvature or angulation of the femoral shaft, or unfeasible hip dislocation. However, the possibility that the intramedullary approach may need to be converted to a transfemoral approach should be anticipated. Thus, preoperative planning must include determination of the optimal length of a femoral osteotomy or femoral flap, should one be needed, and the surgeon must have access to all the revision implants and tools that might be needed for re-implantation. Experience with the various techniques is indispensable, as a well-performed extensive approach is associated with less morbidity than a fracture or trajectory error. There are three main techniques, which are described here: intramedullary extraction of a cementless stem, intramedullary extraction of a cemented stem, and transfemoral extraction through an extended trochanterotomy. The patients should receive detailed information on the difficulties of femoral stem removal and on the available solutions. PMID:26797009

  4. Renormalization Group Trajectories Between Two Fixed Points

    NASA Astrophysics Data System (ADS)

    Abdesselam, Abdelmalek

    2010-03-01

    We report on our recent rigorous construction of complete renormalization group trajectories between two fixed points for the three-dimensional phi-four model with modified propagator considered by Brydges, Mitter and Scoppola (BMS). These are discrete critical trajectories which connect the ultraviolet Gaussian fixed point to the nontrivial BMS infrared fixed point which is an analogue of the Wilson-Fisher fixed point. The renormalization group map is defined rigorously and nonperturbatively, without using the hierarchical approximation. The trajectories are constructed by a fixed point argument in a suitable Banach space of sequences, where one perturbs a nonlinear one-dimensional iteration.

  5. Simple Fixed Functional Space Maintainer

    PubMed Central

    Sarawgi, Aditi; Marwah, Nikhil; Gumber, Parvind; Dutta, Samir

    2014-01-01

    ABSTRACT% Premature loss of a primary tooth is one of the most common etiology for malocclusion. Space maintainers are employed to prevent this complication. In anterior region, esthetics is an important concern along with function and space management. Fiber-reinforced composite (FRC) retained space maintainer solves all these purposes ef ficiently and ef fectively. In addition, the technique is simple and the appliance is very comfortable inside the oral cavity. Here is a case of premature loss of anterior primary tooth which was replaced by FRC retained esthetic functional space maintainer. The appliance was found to be functioning satisfactorily inside the oral cavity till the last visit (1 Year). How to cite this article: Goenka P, Sarawgi A, Marwah N, Gumber P, Dutta S. Simple Fixed Functional Space Maintainer. Int J Clin Pediatr Dent 2014;7(3):225-228. PMID:25709309

  6. Simple fixed functional space maintainer.

    PubMed

    Goenka, Puneet; Sarawgi, Aditi; Marwah, Nikhil; Gumber, Parvind; Dutta, Samir

    2014-01-01

    Premature loss of a primary tooth is one of the most common etiology for malocclusion. Space maintainers are employed to prevent this complication. In anterior region, esthetics is an important concern along with function and space management. Fiber-reinforced composite (FRC) retained space maintainer solves all these purposes ef ficiently and ef fectively. In addition, the technique is simple and the appliance is very comfortable inside the oral cavity. Here is a case of premature loss of anterior primary tooth which was replaced by FRC retained esthetic functional space maintainer. The appliance was found to be functioning satisfactorily inside the oral cavity till the last visit (1 Year). How to cite this article: Goenka P, Sarawgi A, Marwah N, Gumber P, Dutta S. Simple Fixed Functional Space Maintainer. Int J Clin Pediatr Dent 2014;7(3):225-228.

  7. Expanding the regulatory network that controls nitrogen fixation in Sinorhizobium meliloti: elucidating the role of the two-component system hFixL-FxkR.

    PubMed

    Reyes-González, Alma; Talbi, Chouhra; Rodríguez, Susana; Rivera, Patricia; Zamorano-Sánchez, David; Girard, Lourdes

    2016-06-01

    In Sinorhizobium meliloti, nitrogen fixation is regulated in response to oxygen concentration through the FixL-FixJ two-component system (TCS). Besides this conserved TCS, the field isolate SM11 also encodes the hFixL-FxkR TCS, which is responsible for the microoxic response in Rhizobium etli. Through genetic and physiological assays, we evaluated the role of the hFixL-FxkR TCS in S. meliloti SM11. Our results revealed that this regulatory system activates the expression of a fixKf orthologue (fixKa), in response to low oxygen concentration. Null mutations in either hFixL or FxkR promote upregulation of fixK1, a direct target of FixJ. Furthermore, the absence of this TCS translates into higher nitrogen fixation values as well as higher expression of fixN1 in nodules. Individual mutations in each of the fixK-like regulators encoded in the S. meliloti SM11 genome do not completely restrict fixN1 or fixN2 expression, pointing towards redundancy among these regulators. Both copies of fixN are necessary to achieve optimal levels of nitrogen fixation. This work provides evidence that the hFixL-FxkR TCS is activated in response to low oxygen concentration in S. meliloti SM11 and that it negatively regulates the expression of fixK1, fixN1 and nitrogen fixation. PMID:27010660

  8. Expanding the regulatory network that controls nitrogen fixation in Sinorhizobium meliloti: elucidating the role of the two-component system hFixL-FxkR.

    PubMed

    Reyes-González, Alma; Talbi, Chouhra; Rodríguez, Susana; Rivera, Patricia; Zamorano-Sánchez, David; Girard, Lourdes

    2016-06-01

    In Sinorhizobium meliloti, nitrogen fixation is regulated in response to oxygen concentration through the FixL-FixJ two-component system (TCS). Besides this conserved TCS, the field isolate SM11 also encodes the hFixL-FxkR TCS, which is responsible for the microoxic response in Rhizobium etli. Through genetic and physiological assays, we evaluated the role of the hFixL-FxkR TCS in S. meliloti SM11. Our results revealed that this regulatory system activates the expression of a fixKf orthologue (fixKa), in response to low oxygen concentration. Null mutations in either hFixL or FxkR promote upregulation of fixK1, a direct target of FixJ. Furthermore, the absence of this TCS translates into higher nitrogen fixation values as well as higher expression of fixN1 in nodules. Individual mutations in each of the fixK-like regulators encoded in the S. meliloti SM11 genome do not completely restrict fixN1 or fixN2 expression, pointing towards redundancy among these regulators. Both copies of fixN are necessary to achieve optimal levels of nitrogen fixation. This work provides evidence that the hFixL-FxkR TCS is activated in response to low oxygen concentration in S. meliloti SM11 and that it negatively regulates the expression of fixK1, fixN1 and nitrogen fixation.

  9. Fixed drug eruption in Nigeria.

    PubMed

    Nnoruka, Edith N; Ikeh, V O; Mbah, A U

    2006-09-01

    Fixed drug eruption (FDE) causes cosmetic embarrassment in Nigerian patients, particularly when the characteristic hyperpigmented patches affect the face and lips. Drugs that have been implicated in the etiology of FDE, and the sites of lesions, may vary from country to country. Antimalarials, such as Fansidar, Fancimef, Maloxine, Amalar, and Metakelfin, were the most common offending agents, accounting for 38% of FDEs, followed by trimethoprim + sulfamethoxazole (co-trimoxazole) (28%), dipyrones (10%), Butazolidin (6%), thiacetazone (6%), metronidazole (4%), paracetamol (3%), and naproxen (3%). Lesions induced by the combination of sulfadoxine and pyrimethamine (in antimalarials) mainly involved the face and lips. In most cases, patients took these sulfa-containing antimalarials in combination with numerous other drugs, particularly analgesics. Unlike chloroquine-induced pruritus, which affects most Africans, the association between antimalarials and FDE has not been well documented in our region. Co-trimoxazole was associated more often than antimalarials with FDEs involving the mucocutaneous junctions of the genitalia and lips. Males with genital lesions on the glans penis represented 11 (48%) of those with co-trimoxazole hypersensitivity. The trunk and limbs were affected mainly by pyrazoles and Butazolidin, respectively; however, solitary lesions on the trunk were usually due to co-trimoxazole, whereas solitary lesions on the limbs were associated with Butazolidin.

  10. Updraft Fixed Bed Gasification Aspen Plus Model

    SciTech Connect

    2007-09-27

    The updraft fixed bed gasification model provides predictive modeling capabilities for updraft fixed bed gasifiers, when devolatilization data is available. The fixed bed model is constructed using Aspen Plus, process modeling software, coupled with a FORTRAN user kinetic subroutine. Current updraft gasification models created in Aspen Plus have limited predictive capabilities and must be "tuned" to reflect a generalized gas composition as specified in literature or by the gasifier manufacturer. This limits the applicability of the process model.

  11. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway..., microwave communications, electrical power and similar towers, poles and structures, including stacks...

  12. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... applies to all fixed ladders except: (1) Ladders forming an integral part of railway cars, highway..., microwave communications, electrical power and similar towers, poles and structures, including stacks...

  13. Differential cross-sections with hard targets

    NASA Astrophysics Data System (ADS)

    Brun, J. L.; Pacheco, A. F.

    2005-09-01

    When the concept of scattering differential cross-section is introduced in classical mechanics textbooks, usually it is first supposed that the target is a fixed, hard sphere. In this paper we calculate the scattering differential cross-section in the case of the hard target being a fixed figure of revolution of any shape. When the target is a paraboloid of revolution, we find the well-known formula corresponding to Rutherford's scattering. In addition, we analyse the inverse problem, i.e. given a differential cross-section, what is the profile of the corresponding hard target?

  14. Fixed-trim re-entry guidance analysis

    NASA Technical Reports Server (NTRS)

    Gracey, C.; Cliff, E. M.; Lutze, F. H.; Kelley, H. J.

    1981-01-01

    The terminal guidance problem for a fixed-trim re-entry body is formulated with the objective of synthesizing a closed-loop steering law. A transformation of variables and subsequent linearization of the motion, with the sight-line to the target as a reference, reduces the order of the state system for the guidance problem. The reduced order system, although nonlinear and time-varying, is simple enough to lend itself to synthesis of a class of guidance laws. A generalization of the feedforward device of classical control theory is successfully employed for compensation of roll autopilot lags. The proposed steering law exhibits superior miss-distance performance in a computational comparison with existing fixed-trim guidance laws.

  15. Error tolerance in an NMR implementation of Grover's fixed-point quantum search algorithm

    SciTech Connect

    Xiao Li; Jones, Jonathan A.

    2005-09-15

    We describe an implementation of Grover's fixed-point quantum search algorithm on a nuclear magnetic resonance quantum computer, searching for either one or two matching items in an unsorted database of four items. In this algorithm the target state (an equally weighted superposition of the matching states) is a fixed point of the recursive search operator, so that the algorithm always moves towards the desired state. The effects of systematic errors in the implementation are briefly explored.

  16. Fixed-Response Questions with a Difference.

    ERIC Educational Resources Information Center

    Johnstone, Alex H.; Ambusaidi, Abdullah

    2002-01-01

    Offers three types of fixed-response questions that are designed to overcome drawbacks appearing in the conventional forms of fixed-response questions such as not allowing the examiner to investigate reasoning, background, or prevent guessing. (Contains 14 references.) (Author/YDS)

  17. 29 CFR 1910.27 - Fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Fixed ladders. 1910.27 Section 1910.27 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.27 Fixed ladders. (a) Design requirements—(1) Design considerations. All ladders, appurtenances, and fastenings shall be designed to...

  18. 78 FR 20705 - Fixed Income Roundtable

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Fixed Income Roundtable AGENCY: Securities and Exchange Commission. ACTION: Notice of roundtable..., efficiency, and other aspects of fixed income markets. The roundtable will focus on the municipal...

  19. Gaining Insight into an Organization's Fixed Assets.

    ERIC Educational Resources Information Center

    Hardy, Elisabet

    2003-01-01

    Discusses issues related to school district implementation of June 2001 Government Accounting Standards Board (GASB) Statement 34 designed to change how schools report fixed assets. Includes planning for GASB implementation, conducting fixed-asset inventories, and making time for GASB reporting. (PKP)

  20. Negotiating a Fixed-Unit Price Contract.

    ERIC Educational Resources Information Center

    Pasquale, Mathew; Morrison, Wade

    1986-01-01

    Discusses the concept of "fixed-unit price contracting," an arrangement that is becoming popular with private industry councils (PICs). Guidelines include (1) find out as much as you can about the PIC's requirements; (2) figure out whether you can meet the PIC's requirements; and (3) keep in mind that most elements of a fixed-unit price contract…

  1. Targets and targeting.

    PubMed

    Will, E

    2001-08-01

    Using the vocabulary of ballistics in medicine for emphasis can result in misleading exaggeration and semantic confusion. The dual meaning of target as either aiming point (aim at) or outcome (aim to achieve) creates a muddle in the efforts to comply with quality assurance initiatives. Disentangling the two meanings allows new approaches to the clinical technology required in a modern health care environment. An example can be shown in new strategies for the management of renal anemia with iron and erythropoietin. The potential to shape outcome distributions through validated, preemptive intervention thresholds offers the predictable results required by patients and payers. Using the management of patient cohorts as a platform for outcomes creates no necessary conflict with individualized clinical care. Future guideline statements should include the likely characteristics of compliant outcome populations, as a prompt to clinical goals and as an indication of the necessary cost and effort of compliance with treatment standards. Overemphasis in language is no substitute for considered clinical methodology.

  2. Stimulus properties of fixed-interval responses.

    PubMed

    Buchman, I B; Zeiler, M D

    1975-11-01

    Responses in the first component of a chained schedule produced a change to the terminal component according to a fixed-interval schedule. The number of responses emitted in the fixed interval determined whether a variable-interval schedule of food presentation or extinction prevailed in the terminal component. In one condition, the variable-interval schedule was in effect only if the number of responses during the fixed interval was less than that specified; in another condition, the number of responses had to exceed that specified. The number of responses emitted in the fixed interval did not shift markedly in the direction required for food presentation. Instead, responding often tended to change in the opposite direction. Such an effect indicated that differential food presentation did not modify the reference behavior in accord with the requirement, but it was consistent with other data on fixed-interval schedule performance. Behavior in the terminal component, however, did reveal sensitivity to the relation between total responses emitted in the fixed interval and the availability of food. Response rate in the terminal component was a function of the proximity of the response number emitted in the fixed interval to that required for food presentation. Thus, response number served as a discriminative stimulus controlling subsequent performance.

  3. Updraft Fixed Bed Gasification Aspen Plus Model

    2007-09-27

    The updraft fixed bed gasification model provides predictive modeling capabilities for updraft fixed bed gasifiers, when devolatilization data is available. The fixed bed model is constructed using Aspen Plus, process modeling software, coupled with a FORTRAN user kinetic subroutine. Current updraft gasification models created in Aspen Plus have limited predictive capabilities and must be "tuned" to reflect a generalized gas composition as specified in literature or by the gasifier manufacturer. This limits the applicability ofmore » the process model.« less

  4. [FIXED COMBINATION ATORVASTATIN-EZETIMIBE (ATOZET®)].

    PubMed

    Scheen, A J

    2016-01-01

    Cardiovascular prevention in subjects at high or very high risk requires a drastic reduction in LDL cholesterol according to the concept "the lower, the better". The combination of an inhibitor of cholesterol synthesis and a selective inhibitor of intestinal absorption results in a complementary and synergistic LDL-lowering activity. Besides a first fixed combination ezetimibe-simvastatin (Inegy®), a new fixed combination is presented, Atozet® that combines atorvastatin and ezetimibe. Because atorvastatin is more potent than simvastatin, this novel fixed combination should facilitate reaching therapeutic goals in terms of LDL cholesterol amongst patients with severe hypercholesterolaemia and/or at high or very high cardiovascular risk.

  5. Finite volume QCD at fixed topological charge

    SciTech Connect

    Aoki, Sinya; Fukaya, Hidenori; Hashimoto, Shoji; Onogi, Tetsuya

    2007-09-01

    In finite volume the partition function of QCD with a given {theta} is a sum of different topological sectors with a weight primarily determined by the topological susceptibility. If a physical observable is evaluated only in a fixed topological sector, the result deviates from the true expectation value by an amount proportional to the inverse space-time volume 1/V. Using the saddle point expansion, we derive formulas to express the correction due to the fixed topological charge in terms of a 1/V expansion. Applying this formula, we propose a class of methods to determine the topological susceptibility in QCD from various correlation functions calculated in a fixed topological sector.

  6. NASA Fixed Wing Project: Green Technologies for Future Aircraft Generation

    NASA Technical Reports Server (NTRS)

    Del Rosario, Ruben; Koudelka, John M.; Wahls, Rich; Madavan, Nateri

    2014-01-01

    Commercial aviation relies almost entirely on subsonic fixed wing aircraft to constantly move people and goods from one place to another across the globe. While air travel is an effective means of transportation providing an unmatched combination of speed and range, future subsonic aircraft must improve substantially to meet efficiency and environmental targets.The NASA Fundamental Aeronautics Fixed Wing (FW) Project addresses the comprehensive challenge of enabling revolutionary energy efficiency improvements in subsonic transport aircraft combined with dramatic reductions in harmful emissions and perceived noise to facilitate sustained growth of the air transportation system. Advanced technologies and the development of unconventional aircraft systems offer the potential to achieve these improvements. Multidisciplinary advances are required in aerodynamic efficiency to reduce drag, structural efficiency to reduce aircraft empty weight, and propulsive and thermal efficiency to reduce thrust-specific energy consumption (TSEC) for overall system benefit. Additionally, advances are required to reduce perceived noise without adversely affecting drag, weight, or TSEC, and to reduce harmful emissions without adversely affecting energy efficiency or noise.The paper will highlight the Fixed Wing project vision of revolutionary systems and technologies needed to achieve these challenging goals. Specifically, the primary focus of the FW Project is on the N+3 generation; that is, vehicles that are three generations beyond the current state of the art, requiring mature technology solutions in the 2025-30 timeframe

  7. Anderson Acceleration for Fixed-Point Iterations

    SciTech Connect

    Walker, Homer F.

    2015-08-31

    The purpose of this grant was to support research on acceleration methods for fixed-point iterations, with applications to computational frameworks and simulation problems that are of interest to DOE.

  8. Gravitational Fixed Points from Perturbation Theory

    SciTech Connect

    Niedermaier, Max R.

    2009-09-04

    The fixed point structure of the renormalization flow in higher derivative gravity is investigated in terms of the background covariant effective action using an operator cutoff that keeps track of powerlike divergences. Spectral positivity of the gauge fixed Hessian can be satisfied upon expansion in the asymptotically free higher derivative coupling. At one-loop order in this coupling strictly positive fixed points are found for the dimensionless Newton constant g{sub N} and the cosmological constant lambda, which are determined solely by the coefficients of the powerlike divergences. The renormalization flow is asymptotically safe with respect to this fixed point and settles on a lambda(g{sub N}) trajectory after O(10) units of the renormalization mass scale to accuracy 10{sup -7}.

  9. Gravitational fixed points from perturbation theory.

    PubMed

    Niedermaier, Max R

    2009-09-01

    The fixed point structure of the renormalization flow in higher derivative gravity is investigated in terms of the background covariant effective action using an operator cutoff that keeps track of powerlike divergences. Spectral positivity of the gauge fixed Hessian can be satisfied upon expansion in the asymptotically free higher derivative coupling. At one-loop order in this coupling strictly positive fixed points are found for the dimensionless Newton constant g(N) and the cosmological constant lambda, which are determined solely by the coefficients of the powerlike divergences. The renormalization flow is asymptotically safe with respect to this fixed point and settles on a lambda(g(N)) trajectory after O(10) units of the renormalization mass scale to accuracy 10(-7).

  10. Stabilising Springs for Fixed Lingual Retainer

    PubMed Central

    Karthikeyan, M.K.; Ramachandraprabhakar; Saravanan, R.; Rajvikram, N.; Kuppuchamy

    2013-01-01

    Most treated malocclusion needs fixed lingual retention. To stabilise fixed lingual retainer in the exact location needs proper stabilisation. Proper stabilization requires a holding spring. This Stabilising Spring should be easy to fabricate and help the clinician to stabilise the retainer quickly and save the chair side time. More over it should not irritate the mucosa and should be easy to insert and remove. PMID:24392431

  11. DNA extraction from formalin-fixed material.

    PubMed

    Campos, Paula F; Gilbert, Thomas M P

    2012-01-01

    The principal challenges facing PCR-based analyses of DNA extracted from formalin-fixed materials are fragmentation of the DNA and cross-linked protein-DNA complexes. Here, we present an efficient protocol to extract DNA from formalin-fixed or paraffin-embedded tissues (FFPE). In this protocol, protein-DNA cross-links are reversed using heat and alkali treatment, yielding significantly longer fragments and larger amounts of PCR-amplifiable DNA than standard DNA extraction protocols.

  12. Characterizations of fixed points of quantum operations

    SciTech Connect

    Li Yuan

    2011-05-15

    Let {phi}{sub A} be a general quantum operation. An operator B is said to be a fixed point of {phi}{sub A}, if {phi}{sub A}(B)=B. In this note, we shall show conditions under which B, a fixed point {phi}{sub A}, implies that B is compatible with the operation element of {phi}{sub A}. In particular, we offer an extension of the generalized Lueders theorem.

  13. Regulation of the fixA gene and fixBC operon in Bradyrhizobium japonicum.

    PubMed Central

    Gubler, M; Hennecke, H

    1988-01-01

    The transcriptional start site of the Bradyrhizobium japonicum fixBC operon was identified by nuclease S1 mapping. It was located approximately 700 base pairs upstream of fixB and was preceded by a promoter sequence that showed strong homology to the B. japonicum fixA promoter and thus to the general nif consensus promoter sequence. Further transcript mapping experiments revealed that fixA and fixBC transcription in B. japonicum strictly depended on the presence of the regulatory gene nifA and on low oxygen partial pressure. Consistent with these data, chromosomally integrated fixA- and fixB-lacZ fusions expressed beta-galactosidase activity only in the wild type but not in a nifA mutant and only under microaerobic but not aerobic growth conditions. The presence of nifA accounted for a 19-fold and 44-fold activation of the fixA and fixB promoters, respectively. These results show that the fixA and fixBC genes are regulated in a way similar to that of the nitrogenase genes nifH and nifDK. A very peculiar finding was that the fixA and fixB promoters, when they were located on plasmids, could hardly be activated by the NifA protein, irrespective of whether this was tested in Escherichia coli or B. japonicum backgrounds. This is in clear contrast to the situation with nifH and nifD promoters. Images PMID:3343218

  14. Precise Point Positioning with Partial Ambiguity Fixing

    PubMed Central

    Li, Pan; Zhang, Xiaohong

    2015-01-01

    Reliable and rapid ambiguity resolution (AR) is the key to fast precise point positioning (PPP). We propose a modified partial ambiguity resolution (PAR) method, in which an elevation and standard deviation criterion are first used to remove the low-precision ambiguity estimates for AR. Subsequently the success rate and ratio-test are simultaneously used in an iterative process to increase the possibility of finding a subset of decorrelated ambiguities which can be fixed with high confidence. One can apply the proposed PAR method to try to achieve an ambiguity-fixed solution when full ambiguity resolution (FAR) fails. We validate this method using data from 450 stations during DOY 021 to 027, 2012. Results demonstrate the proposed PAR method can significantly shorten the time to first fix (TTFF) and increase the fixing rate. Compared with FAR, the average TTFF for PAR is reduced by 14.9% for static PPP and 15.1% for kinematic PPP. Besides, using the PAR method, the average fixing rate can be increased from 83.5% to 98.2% for static PPP, from 80.1% to 95.2% for kinematic PPP respectively. Kinematic PPP accuracy with PAR can also be significantly improved, compared to that with FAR, due to a higher fixing rate. PMID:26067196

  15. Sputter target

    DOEpatents

    Gates, Willard G.; Hale, Gerald J.

    1980-01-01

    The disclosure relates to an improved sputter target for use in the deposition of hard coatings. An exemplary target is given wherein titanium diboride is brazed to a tantalum backing plate using a gold-palladium-nickel braze alloy.

  16. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  17. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  18. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  19. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  20. 48 CFR 16.204 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  1. Evidence for a fixed capacity limit in attending multiple locations.

    PubMed

    Ester, Edward F; Fukuda, Keisuke; May, Lisa M; Vogel, Edward K; Awh, Edward

    2014-03-01

    A classic question concerns whether humans can attend multiple locations or objects at once. Although it is generally agreed that the answer to this question is "yes," the limits on this ability are subject to extensive debate. According to one view, attentional resources can be flexibly allocated to a variable number of locations, with an inverse relationship between the number of selected locations and the quality of information processing at each location. Alternatively, these resources might be quantized in a "discrete" fashion that enables concurrent access to a small number of locations. Here, we report a series of experiments comparing these alternatives. In each experiment, we cued participants to attend a variable number of spatial locations and asked them to report the orientation of a single, briefly presented target. In all experiments, participants' orientation report errors were well-described by a model that assumes a fixed upper limit in the number of locations that can be attended. Conversely, report errors were poorly described by a flexible-resource model that assumes no fixed limit on the number of locations that can be attended. Critically, we showed that these discrete limits were predicted by cue-evoked neural activity elicited before the onset of the target array, suggesting that performance was limited by selection processes that began prior to subsequent encoding and memory storage. Together, these findings constitute novel evidence supporting the hypothesis that human observers can attend only a small number of discrete locations at an instant.

  2. 30 CFR 57.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection for inclined fixed ladders. 57.11026... and Escapeways Travelways-Surface Only § 57.11026 Protection for inclined fixed ladders. Fixed ladders... ladders....

  3. 30 CFR 57.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Protection for inclined fixed ladders. 57.11026... and Escapeways Travelways-Surface Only § 57.11026 Protection for inclined fixed ladders. Fixed ladders... ladders....

  4. Carbon-Fixing Reactions of Photosynthesis.

    PubMed

    2016-07-01

    Summaryplantcell;28/7/tpc.116.tt0716/FIG1F1fig1Photosynthesis in plants converts the energy of sunlight into chemical energy. Although photosynthesis involves many proteins and catalytic processes, it often is described as two sets of reactions, the light-dependent reactions and the carbon-fixing reactions. This lesson introduces the core biochemistry of the carbon-fixing reactions of photosynthesis, as well as its variations, C4 and CAM. Finally, it addresses how and why plants are affected by rising atmospheric CO2 levels, and research efforts to increase photosynthetic efficiency in current and future conditions.

  5. Carbon-Fixing Reactions of Photosynthesis.

    PubMed

    2016-07-01

    Summaryplantcell;28/7/tpc.116.tt0716/FIG1F1fig1Photosynthesis in plants converts the energy of sunlight into chemical energy. Although photosynthesis involves many proteins and catalytic processes, it often is described as two sets of reactions, the light-dependent reactions and the carbon-fixing reactions. This lesson introduces the core biochemistry of the carbon-fixing reactions of photosynthesis, as well as its variations, C4 and CAM. Finally, it addresses how and why plants are affected by rising atmospheric CO2 levels, and research efforts to increase photosynthetic efficiency in current and future conditions. PMID:27493209

  6. Quantum entanglement and fixed-point bifurcations

    SciTech Connect

    Hines, Andrew P.; McKenzie, Ross H.; Milburn, G.J.

    2005-04-01

    How does the classical phase-space structure for a composite system relate to the entanglement characteristics of the corresponding quantum system? We demonstrate how the entanglement in nonlinear bipartite systems can be associated with a fixed-point bifurcation in the classical dynamics. Using the example of coupled giant spins we show that when a fixed point undergoes a supercritical pitchfork bifurcation, the corresponding quantum state--the ground state--achieves its maximum amount of entanglement near the critical point. We conjecture that this will be a generic feature of systems whose classical limit exhibits such a bifurcation.

  7. Reading with fixed and variable character pitch.

    PubMed

    Arditi, A; Knoblauch, K; Grunwald, I

    1990-10-01

    We compared the effects of fixed and variable (proportional) spacing on reading speeds and found variable pitch to yield better performance at medium and large character sizes and fixed pitch to be superior for character sizes approaching the acuity limit. The data indicate at least two crowding effects at the smallest sizes: one that interferes with individual character identification and one that interferes with word identification. A control experiment using rapid serial visual presentation suggests that it is the greater horizontal compression and consequently reduced eye-movement requirements of variable pitch that are responsible for its superiority at medium and large character sizes.

  8. Direct Entry Enrollments of Miami-Dade County High School Graduates: Fall and Spring (Winter) Terms, 1996-97 through 2000-01. Research Report.

    ERIC Educational Resources Information Center

    Baldwin, Anne

    This document is a report on the enrollment of high school graduates from Miami-Dade County (Florida) at Miami-Dade Community College (M-DCC). The report includes statistics on students from Florida high schools as well as out-of-state high schools. Provided are demographics on the students, including ethnicity, gender, and type of high school…

  9. Hydrology and cycling of nitrogen and phosphorus in Little Bean Marsh : a remnant riparian wetland along the Missouri River in Platte County, Missouri, 1996-97

    USGS Publications Warehouse

    Blevins, Dale W.

    2004-01-01

    The lack of concurrent water-quality and hydrologic data on riparian wetlands in the Midwestern United States has resulted in a lack of knowledge about the water-quality functions that these wetlands provide. Therefore, Little Bean Marsh, a remnant riparian wetland along the Missouri River, was investigated in 1996 and 1997 primarily to determine the magnitude and character of selected water-quality benefits that can be produced in such a wetland and to identify critical processes that can be managed in remnant or restored riparian wetlands for amelioration of water quality. Little Bean Marsh averages 69 hectares in size, has a maximum depth of about 1 meter, and the majority of the marsh is covered by macrophytes. In 1997, 41 percent of the water received by Little Bean Marsh was from direct precipitation, 14 percent was from ground-water seepage, 30 percent from watershed runoff, and 15 percent was backflow from Bean Lake. Although, Little Bean Marsh was both a ground-water recharge and discharge area, discharge to the marsh was three times the recharge to ground water. Ground-water levels closely tracked marsh water levels indicating a strong hydraulic connection between ground water and the marsh. Reduced surface runoff and ground-water availability are stabilizing influences on marsh hydrology and probably contribute to the persistence of emergent vegetation. The rapid hydraulic connection between Little Bean Marsh and ground water indicates that the hydrologic regime of most wetlands along the lower Missouri River is largely a function of the altitude of the marsh bottom relative to the altitude of the water table. More water was lost from the marsh through evapotranspiration (59 percent) than all other pathways combined. This is partially because the transpiration process of abundant macrophytes can greatly contribute to the evapotranspiration above that lost from open water surfaces. Surface outflow accounted for 36 percent and ground-water seepage accounted for only 5 percent of the losses. Large residence times allows the marsh to greatly affect water quality before water escapes as ground-water recharge or surface outflow. The shallowness of Little Bean Marsh and ion exclusion during ice formation caused the highest specific conductances of 1,100 to 1,300 microsiemens per centimeter at 25 degrees Celsius to occur during the winter. This concentration of dissolved solutes under ice can make wetlands more vulnerable to toxic contaminants than deeper surface-water bodies. Dissolved oxygen was less than 5 mg/L (milligrams per liter) for 3 to 4 months and near 0 mg/L for about 1 month in summer. Despite depths of less than 1 meter, temperature stratification persisted more than 3 months during the summers of 1996 and 1997, preventing mixing and contributing to periods of anoxia. Shallow depths and extended periods of anoxia in the marsh limit the ability of some organisms to escape high-temperature stress. Turbidity in Little Bean Marsh usually was low for several reasons: sediment loadings from the largely flood-plain drainage were low, emergent vegetation shade out algae and shield the water from wind, and high concentrations of bivalent cations increase flocculation rates of inorganic suspended material. The high concentrations of bivalent cations was largely because of a substantial amount of ground-water seepage into the marsh. Dissolved organic nitrogen was the dominant nitrogen species in Little Bean Marsh. Denitrification and biotic uptake kept more than 62 percent of nitrate (NO3) and 43 percent of ammonium (NH4) concentrations in marsh samples less than a detection limit of 0.005 mg/L. This contrasts with the Missouri River where inorganic NO3 dominates. Consequently, artificial flood-plain drainage that bypasses riparian wetlands likely deliver substantially more biotically available inorganic nitrogen to receiving waters than surface water that has been routed through a remnant wetland. Aver

  10. Direct Loan Evaluation. Case Study Summary Report: Academic Year 1996-97. Volume One--Study Findings [and] Volume Two-- Case Study Reports.

    ERIC Educational Resources Information Center

    Macro International, Inc., Calverton, MD.

    As part of a 5-year evaluation of the William D. Ford Federal Direct Loan Program, 12 participating institutions of higher education were visited to examine the diversity of approaches used by schools in planning for and implementing the program. The schools included public and private two- and four-year institutions and proprietary schools. Major…

  11. The Journal of Staff, Program, & Organization Development, Volume 14, Numbers 1-4, 1996-97. New Forums Faculty Development Series.

    ERIC Educational Resources Information Center

    Neal, Edward, Ed.

    1997-01-01

    This quarterly publication serves as a medium for the exchange of ideas regarding the planning, design, implementation, and evaluation of professional development practices at two- and four-year colleges. The four issues in volume 14 feature the following articles: (1) "A Home-Grown Faculty Development Program," (Jane T. Rauton); (2) "Creating…

  12. Self Evaluation Guide for Institutional Participation in Title IV and Other Federal Progams. 12th Edition. 1995-96 and 1996-97.

    ERIC Educational Resources Information Center

    National Association of Student Financial Aid Administrators, Washington, DC.

    This guide is designed as an in-house tool for postsecondary educational institutions to evaluate the efficiency and effectiveness of their administration of financial aid programs in compliance with federal laws and regulations. References to current regulations or, where final regulations have not yet been issued, to statute, are included for…

  13. Changing clinical and biological manifestations of dengue during the dengue-2 epidemic in French Polynesia in 1996/97--description and analysis in a prospective study.

    PubMed

    Deparis, X; Murgue, B; Roche, C; Cassar, O; Chungue, E

    1998-11-01

    In August 1996 dengue-2 virus was detected in French Polynesia for the first time since 1976. A prospective study was conducted from November 1996 to April 1997. Each time one of 7 physicians suspected dengue, the patient was enrolled and epidemiological, clinical and biological data were recorded. Dengue diagnosis was confirmed by virus isolation and IgM detection. The aims of this study were to find clinical and biological predictive factors constituting a specific profile of dengue (DF) and dengue haemorrhagic fever (DHF/DSS) and to assess the possibility of diagnosing dengue at primary health care level using clinical criteria and basic laboratory parameters. Of 298 clinically suspect cases, 196 (66%) were confirmed as dengue. The association of macular rash, pruritus, low platelet count and leukopenia was statistically predictive of dengue but not clinically, since these four signs occur in many other viral infections. As the prevalence of clinical and biological manifestations varied over time in our study, a specific profile useful for dengue diagnosis cannot be defined. With six cases of DHF, the morbidity of this dengue-2 outbreak was very low despite the sequential infection scheme DEN-3/DEN-2. The clinical expression of dengue could depend on a specific virus strain circulating in a specific population in a particular place, with varying virulence over time.

  14. Water-quality data for the Rio Grande between Picacho Bridge near Las Cruces and Calle del Norte Bridge near Mesilla, New Mexico, 1996-97

    USGS Publications Warehouse

    Huff, G.F.

    1998-01-01

    The City of Las Cruces is concerned about water quality in a reach of the Rio Grande that receives outfall from the City of Las Cruces wastewater-treatment plant. Water-quality samples were collected from the Rio Grande at Picacho Bridge near Las Cruces, New Mexico; from the sampling site at the City of Las Cruces wastewater-treatment plant; and from the Rio Grande at Calle del Norte Bridge near Mesilla, New Mexico. The samples were collected on 12 days from August 6, 1996, to February 28, 1997, and were analyzed for a suite of dissolved and total constituents including trace metals. Instantaneous stream discharge was measured concurrently with collection of the Rio Grande samples. At the wastewater- treatment plant, the City of Las Cruces provided instantaneous discharge rates concurrent with sampling. Quality-control measures used in this study to ensure analytical accuracy included replicate sampling, replicate analysis of split samples, ambient blanks, equipment blanks, and analysis of standard reference water samples.

  15. Maps showing the change in modern sediment thickness on the Inner Continental Shelf offshore of Fire Island, New York, between 1996-97 and 2011

    USGS Publications Warehouse

    Schwab, William C.; Baldwin, Wayne E.; Denny, Jane F.

    2015-01-01

    The U.S. Geological Survey mapped approximately 336 square kilometers of the lower shoreface and inner continental shelf offshore of Fire Island, New York, in 1996 and 1997, using high-resolution sidescan-sonar and seismic-reflection systems, and again in 2011, using interferometric sonar and high-resolution chirp seismic-reflection systems. This report presents a comparison of sediment thickness and distribution as mapped during these two investigations. These spatial data support research on the Quaternary evolution of the Fire Island coastal system and provide baseline information for research on coastal processes along southern Long Island.

  16. LIQUID TARGET

    DOEpatents

    Martin, M.D.; Salsig, W.W. Jr.

    1959-01-13

    A liquid handling apparatus is presented for a liquid material which is to be irradiated. The apparatus consists essentially of a reservoir for the liquid, a target element, a drain tank and a drain lock chamber. The target is in the form of a looped tube, the upper end of which is adapted to be disposed in a beam of atomic particles. The lower end of the target tube is in communication with the liquid in the reservoir and a means is provided to continuously circulate the liquid material to be irradiated through the target tube. Means to heat the reservoir tank is provided in the event that a metal is to be used as the target material. The apparatus is provided with suitable valves and shielding to provide maximum safety in operation.

  17. Route Optimization for Offloading Congested Meter Fixes

    NASA Technical Reports Server (NTRS)

    Xue, Min; Zelinski, Shannon

    2016-01-01

    The Optimized Route Capability (ORC) concept proposed by the FAA facilitates traffic managers to identify and resolve arrival flight delays caused by bottlenecks formed at arrival meter fixes when there exists imbalance between arrival fixes and runways. ORC makes use of the prediction capability of existing automation tools, monitors the traffic delays based on these predictions, and searches the best reroutes upstream of the meter fixes based on the predictions and estimated arrival schedules when delays are over a predefined threshold. Initial implementation and evaluation of the ORC concept considered only reroutes available at the time arrival congestion was first predicted. This work extends previous work by introducing an additional dimension in reroute options such that ORC can find the best time to reroute and overcome the 'firstcome- first-reroute' phenomenon. To deal with the enlarged reroute solution space, a genetic algorithm was developed to solve this problem. Experiments were conducted using the same traffic scenario used in previous work, when an arrival rush was created for one of the four arrival meter fixes at George Bush Intercontinental Houston Airport. Results showed the new approach further improved delay savings. The suggested route changes from the new approach were on average 30 minutes later than those using other approaches, and fewer numbers of reroutes were required. Fewer numbers of reroutes reduce operational complexity and later reroutes help decision makers deal with uncertain situations.

  18. Stress tolerant crops from nitrogen fixing trees

    SciTech Connect

    Becker, R.; Saunders, R.M.

    1983-01-01

    Notes are given on the nutritional quality and uses of: pods of Geoffroea decorticans, a species tolerant of saline and limed soils and saline water; seeds of Olneya tesota which nodulates readily and fixes nitrogen and photosynthesizes at low water potential; and pods of Prosopis chilensis and P. tamarugo which tolerate long periods without rain. 3 references.

  19. Fixing Advising: A Model for Faculty Advising

    ERIC Educational Resources Information Center

    Crocker, Robert M.; Kahla, Marlene; Allen, Charlotte

    2014-01-01

    This paper addresses mandates to fix the advising process with a focus on faculty advising systems. Measures of student success and satisfaction, administrative issues, and faculty concerns are among the many factors discussed. Regression analysis is used to explore long-voiced faculty complaints that students do not follow advice. A case study is…

  20. Force dynamics in fixed-ratio schedules.

    PubMed

    Pinkston, Jonathan W; McBee, Lindsey N

    2014-03-01

    Fixed-ratio schedules are widely used in behavioral research. Although fixed-ratio schedules often conjure up relationships to work and effort, little is known about effort-related measures in these schedules. Early research had shown that force and effort of operant behavior vary systematically during the execution of ratio schedules, and the goal of the present study was to revisit early research on force dynamics in fixed-ratio schedules. Four rats earned sucrose by pressing an isometric force transducer. Presses produced sucrose after ten or twenty responses. In general, the force of responses increased then decreased systematically across the ratio. The possibility that decreases in force during ratio execution was due to a trade-off with the differential reinforcement of short inter-response times (IRT) was investigated in an additional condition where sucrose was made available according to a tandem fixed-ratio 19 inter-response (IRT)> t schedule. The tandem IRT requirement did not eliminate decreasing trends in force across the ratio; unexpectedly, the tandem requirement did eliminate increases in force early in the ratio, which may reflect sequence-level organization operating in the control of force dynamics. PMID:24315798

  1. Fixed drug eruption related to fluconazole.

    PubMed

    Lai, Olivia; Hsu, Sylvia

    2016-01-01

    Fixed drug eruption (FDE) is a type of cutaneous drug reaction that occurs at the same sites upon re-exposure to specific medications. Herein we discuss the case of a 23-year-old man with a FDE to fluconazole. PMID:27617471

  2. The microanalysis of fixed-interval responding

    PubMed Central

    Gentry, G. David; Weiss, Bernard; Laties, Victor G.

    1983-01-01

    The fixed-interval schedule of reinforcement is one of the more widely studied schedules in the experimental analysis of behavior and is also a common baseline for behavior pharmacology. Despite many intensive studies, the controlling variables and the pattern of behavior engendered are not well understood. The present study examined the microstructure and superstructure of the behavior engendered by a fixed-interval 5- and a fixed-interval 15-minute schedule of food reinforcement in the pigeon. Analysis of performance typical of fixed-interval responding indicated that the scalloped pattern does not result from smooth acceleration in responding, but, rather, from renewed pausing early in the interval. Individual interresponse-time (IRT) analyses provided no evidence of acceleration. There was a strong indication of alternation in shorter-longer IRTs, but these shorter-longer IRTs did not occur at random, reflecting instead a sequential dependency in successive IRTs. Furthermore, early in the interval there was a high relative frequency of short IRTs. Such a pattern of early pauses and short IRTs does not suggest behavior typical of reinforced responding as exemplified by the pattern found near the end of the interval. Thus, behavior from clearly scalloped performance can be classified into three states: postreinforcement pause, interim behavior, and terminal behavior. PMID:16812324

  3. Fixed Drug Eruption Due to Ornidazole

    PubMed Central

    Gupta, Ramji

    2014-01-01

    A 56-year-old male developed an ulcer on his glans penis and mucosae of upper and lower lips 3 days after taking ofloxacin, cephalexin, and ornidazole. Clinically, a provisional diagnosis of fixed drug eruption was made. The causative drug was confirmed by an oral provocation test which triggered a reactivation of all lesions only with ornidazole. PMID:25484435

  4. Microanalysis of fixed-interval responding

    SciTech Connect

    Gentry, G.D.; Weiss, B.; Laties, V.G.

    1983-03-01

    The fixed-interval schedule of reinforcement is one of the more widely studied schedules in the experimental analysis of behavior and is also a common baseline for behavior pharmacology. Despite many intensive studies, the controlling variables and the pattern of behavior engendered are not well understood. The present study examined the microstructure and superstructure of the behavior engendered by a fixed-interval 5- and a fixed-interval 15-minute schedule of food reinforcement in the pigeon. Analysis of performance typical of fixed-interval responding indicated that the scalloped pattern does not result from smooth acceleration in responding, but, rather, from renewed pausing early in the interval. Individual interresponse-time (IRT) analyses provided no evidence of acceleration. There was a strong indication of alternation is shorter-longer IRTs, but these shorter-longer IRTs did not occur at random, reflecting instead a sequential dependency in successive IRTs. Furthermore, early in the interval there was a high relative frequency of short IRTs. Such a pattern of early pauses and short IRTs does not suggest behavior typical of reinforced responding as exemplified by the pattern found near the end of the interval. Thus, behavior from clearly scalloped performance can be classified into three states: postreinforcement pause, interim behavior, and terminal behavior. 31 references, 11 figures, 4 tables.

  5. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and fastened to one or both of the ladder's side rails or to another structure. (2) Fixed ladder means a ladder, including individual rung ladders, permanently attached to a structure, building or piece..., microwave communications, electrical power and similar towers, poles and structures, including stacks...

  6. 29 CFR 1917.118 - Fixed ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and fastened to one or both of the ladder's side rails or to another structure. (2) Fixed ladder means a ladder, including individual rung ladders, permanently attached to a structure, building or piece..., microwave communications, electrical power and similar towers, poles and structures, including stacks...

  7. Fixing the Shadows While Moving the Gnomon

    ERIC Educational Resources Information Center

    Gangui, Alejandro

    2015-01-01

    It is a common practice to fix a vertical gnomon and study the moving shadow cast by it. This shows our local solar time and gives us a hint regarding the season in which we perform the observation. The moving shadow can also tell us our latitude with high precision. In this paper we propose to exchange the roles and while keeping the shadows…

  8. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Electronic position fixing devices. 184.410 Section 184... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device, capable of providing accurate fixes for the area in which the vessel operates, to...

  9. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Electronic position fixing devices. 184.410 Section 184... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device, capable of providing accurate fixes for the area in which the vessel operates, to...

  10. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Electronic position fixing devices. 184.410 Section 184... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device, capable of providing accurate fixes for the area in which the vessel operates, to...

  11. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Electronic position fixing devices. 184.410 Section 184... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device, capable of providing accurate fixes for the area in which the vessel operates, to...

  12. 46 CFR 184.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Electronic position fixing devices. 184.410 Section 184... Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device, capable of providing accurate fixes for the area in which the vessel operates, to...

  13. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Fixed gear identification and marking... West Coast Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked...

  14. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Fixed gear identification and marking... West Coast Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked...

  15. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Standards-Tank fixed roof. 63.902...) National Emission Standards for Tanks-Level 1 § 63.902 Standards—Tank fixed roof. (a) This section applies... fixed roof. This section does not apply to a fixed-roof tank that is also equipped with an...

  16. 48 CFR 1852.216-75 - Payment of fixed fee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Payment of fixed fee. 1852... 1852.216-75 Payment of fixed fee. As prescribed in 1816.307-70(c), insert the following clause: Payment of Fixed Fee (DEC 1988) The fixed fee shall be paid in monthly installments based upon the...

  17. 48 CFR 1852.216-75 - Payment of fixed fee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Payment of fixed fee. 1852... 1852.216-75 Payment of fixed fee. As prescribed in 1816.307-70(c), insert the following clause: Payment of Fixed Fee (DEC 1988) The fixed fee shall be paid in monthly installments based upon the...

  18. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.403 Fixed-price incentive contracts. (a) Description. A fixed-price incentive contract is a fixed-price contract that provides...

  19. 48 CFR 52.216-9 - Fixed Fee-Construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Fixed Fee-Construction. 52....216-9 Fixed Fee—Construction. As prescribed in 16.307(c), insert the following clause in solicitations and contracts when a cost-plus-fixed-fee construction contract is contemplated: Fixed...

  20. 47 CFR 90.235 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Secondary fixed signaling operations. 90.235... fixed signaling operations. Fixed operations may, subject to the following conditions, be authorized on... function is repeated consecutively more than five times. (h) Fixed stations authorized pursuant to...

  1. 47 CFR 90.637 - Restrictions on operational fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Restrictions on operational fixed stations. 90... operational fixed stations. (a) Except for control stations, operational fixed operations will not be... secondary fixed tone signaling and alarm operations authorized in § 90.235 or in paragraph (c) of...

  2. 48 CFR 52.216-9 - Fixed Fee-Construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Fixed Fee-Construction. 52....216-9 Fixed Fee—Construction. As prescribed in 16.307(c), insert the following clause in solicitations and contracts when a cost-plus-fixed-fee construction contract is contemplated: Fixed...

  3. 47 CFR 90.235 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Secondary fixed signaling operations. 90.235... fixed signaling operations. Fixed operations may, subject to the following conditions, be authorized on... function is repeated consecutively more than five times. (h) Fixed stations authorized pursuant to...

  4. 10 CFR 600.29 - Fixed obligation awards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Fixed obligation awards. 600.29 Section 600.29 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.29 Fixed... assistance instruments on a fixed amount basis. Under a fixed obligation award, funds are issued in...

  5. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Standards-Tank fixed roof. 63.902...) National Emission Standards for Tanks-Level 1 § 63.902 Standards—Tank fixed roof. (a) This section applies... fixed roof. This section does not apply to a fixed-roof tank that is also equipped with an...

  6. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Standards-Tank fixed roof. 63.902...) National Emission Standards for Tanks-Level 1 § 63.902 Standards—Tank fixed roof. (a) This section applies... fixed roof. This section does not apply to a fixed-roof tank that is also equipped with an...

  7. 48 CFR 1852.216-78 - Firm fixed price.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Firm fixed price. 1852.216... 1852.216-78 Firm fixed price. As prescribed in 1816.202-70, insert the following clause: Firm Fixed Price (DEC 1988) The total firm fixed price of this contract is $ . (End of clause)...

  8. 10 CFR 600.29 - Fixed obligation awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Fixed obligation awards. 600.29 Section 600.29 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.29 Fixed... assistance instruments on a fixed amount basis. Under a fixed obligation award, funds are issued in...

  9. 47 CFR 90.235 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Secondary fixed signaling operations. 90.235... fixed signaling operations. Fixed operations may, subject to the following conditions, be authorized on... function is repeated consecutively more than five times. (h) Fixed stations authorized pursuant to...

  10. 10 CFR 600.29 - Fixed obligation awards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Fixed obligation awards. 600.29 Section 600.29 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.29 Fixed... assistance instruments on a fixed amount basis. Under a fixed obligation award, funds are issued in...

  11. 48 CFR 1852.216-75 - Payment of fixed fee.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Payment of fixed fee. 1852... 1852.216-75 Payment of fixed fee. As prescribed in 1816.307-70(c), insert the following clause: Payment of Fixed Fee (DEC 1988) The fixed fee shall be paid in monthly installments based upon the...

  12. 48 CFR 1852.216-78 - Firm fixed price.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Firm fixed price. 1852.216... 1852.216-78 Firm fixed price. As prescribed in 1816.202-70, insert the following clause: Firm Fixed Price (DEC 1988) The total firm fixed price of this contract is $ . (End of clause)...

  13. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.403 Fixed-price incentive contracts. (a) Description. A fixed-price incentive contract is a fixed-price contract that provides...

  14. 47 CFR 90.637 - Restrictions on operational fixed stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Restrictions on operational fixed stations. 90... operational fixed stations. (a) Except for control stations, operational fixed operations will not be... secondary fixed tone signaling and alarm operations authorized in § 90.235 or in paragraph (c) of...

  15. 48 CFR 1852.216-78 - Firm fixed price.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Firm fixed price. 1852.216... 1852.216-78 Firm fixed price. As prescribed in 1816.202-70, insert the following clause: Firm Fixed Price (DEC 1988) The total firm fixed price of this contract is $ . (End of clause)...

  16. 2 CFR 200.45 - Fixed amount awards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Fixed amount awards. 200.45 Section 200.45... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.45 Fixed amount awards. Fixed amount... primarily on performance and results. See §§ 200.201 Use of grant agreements (including fixed amount...

  17. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Standards-Tank fixed roof. 63.902...) National Emission Standards for Tanks-Level 1 § 63.902 Standards—Tank fixed roof. (a) This section applies... fixed roof. This section does not apply to a fixed-roof tank that is also equipped with an...

  18. 47 CFR 90.235 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Secondary fixed signaling operations. 90.235... fixed signaling operations. Fixed operations may, subject to the following conditions, be authorized on... function is repeated consecutively more than five times. (h) Fixed stations authorized pursuant to...

  19. 47 CFR 90.637 - Restrictions on operational fixed stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Restrictions on operational fixed stations. 90... operational fixed stations. (a) Except for control stations, operational fixed operations will not be... secondary fixed tone signaling and alarm operations authorized in § 90.235 or in paragraph (c) of...

  20. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.403 Fixed-price incentive contracts. (a) Description. A fixed-price incentive contract is a fixed-price contract that provides...

  1. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.403 Fixed-price incentive contracts. (a) Description. A fixed-price incentive contract is a fixed-price contract that provides...

  2. 47 CFR 90.235 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Secondary fixed signaling operations. 90.235... fixed signaling operations. Fixed operations may, subject to the following conditions, be authorized on... function is repeated consecutively more than five times. (h) Fixed stations authorized pursuant to...

  3. 47 CFR 90.637 - Restrictions on operational fixed stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Restrictions on operational fixed stations. 90... operational fixed stations. (a) Except for control stations, operational fixed operations will not be... secondary fixed tone signaling and alarm operations authorized in § 90.235 or in paragraph (c) of...

  4. 40 CFR 63.902 - Standards-Tank fixed roof.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Standards-Tank fixed roof. 63.902...) National Emission Standards for Tanks-Level 1 § 63.902 Standards—Tank fixed roof. (a) This section applies... fixed roof. This section does not apply to a fixed-roof tank that is also equipped with an...

  5. 10 CFR 600.29 - Fixed obligation awards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Fixed obligation awards. 600.29 Section 600.29 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.29 Fixed... assistance instruments on a fixed amount basis. Under a fixed obligation award, funds are issued in...

  6. 48 CFR 1852.216-78 - Firm fixed price.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Firm fixed price. 1852.216... 1852.216-78 Firm fixed price. As prescribed in 1816.202-70, insert the following clause: Firm Fixed Price (DEC 1988) The total firm fixed price of this contract is $ . (End of clause)...

  7. 50 CFR 660.219 - Fixed gear identification and marking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Fixed gear identification and marking... West Coast Groundfish-Limited Entry Fixed Gear Fisheries § 660.219 Fixed gear identification and marking. (a) Gear identification. (1) Limited entry fixed gear (longline, trap or pot) must be marked...

  8. 48 CFR 52.216-9 - Fixed Fee-Construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Fixed Fee-Construction. 52....216-9 Fixed Fee—Construction. As prescribed in 16.307(c), insert the following clause in solicitations and contracts when a cost-plus-fixed-fee construction contract is contemplated: Fixed...

  9. 48 CFR 52.216-9 - Fixed Fee-Construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Fixed Fee-Construction. 52....216-9 Fixed Fee—Construction. As prescribed in 16.307(c), insert the following clause in solicitations and contracts when a cost-plus-fixed-fee construction contract is contemplated: Fixed...

  10. 48 CFR 52.216-9 - Fixed Fee-Construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Fixed Fee-Construction. 52....216-9 Fixed Fee—Construction. As prescribed in 16.307(c), insert the following clause in solicitations and contracts when a cost-plus-fixed-fee construction contract is contemplated: Fixed...

  11. 48 CFR 1852.216-75 - Payment of fixed fee.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Payment of fixed fee. 1852... 1852.216-75 Payment of fixed fee. As prescribed in 1816.307-70(c), insert the following clause: Payment of Fixed Fee (DEC 1988) The fixed fee shall be paid in monthly installments based upon the...

  12. 48 CFR 16.403 - Fixed-price incentive contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 16.403 Fixed-price incentive contracts. (a) Description. A fixed-price incentive contract is a fixed-price contract that provides...

  13. 48 CFR 1852.216-78 - Firm fixed price.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Firm fixed price. 1852.216... 1852.216-78 Firm fixed price. As prescribed in 1816.202-70, insert the following clause: Firm Fixed Price (DEC 1988) The total firm fixed price of this contract is $ . (End of clause)...

  14. 48 CFR 1852.216-75 - Payment of fixed fee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Payment of fixed fee. 1852... 1852.216-75 Payment of fixed fee. As prescribed in 1816.307-70(c), insert the following clause: Payment of Fixed Fee (DEC 1988) The fixed fee shall be paid in monthly installments based upon the...

  15. 10 CFR 600.29 - Fixed obligation awards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Fixed obligation awards. 600.29 Section 600.29 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES General § 600.29 Fixed... assistance instruments on a fixed amount basis. Under a fixed obligation award, funds are issued in...

  16. Fixed-combination treatments for intraocular hypertension in Chinese patients - focus on bimatoprost-timolol.

    PubMed

    Fang, Yuan; Ling, Zhihong; Sun, Xinghuai

    2015-01-01

    Glaucoma is a common eye disease that can lead to irreversible vision loss if left untreated. The early diagnosis and treatment of primary open-angle glaucoma is challenging, and visual impairment in Chinese glaucoma patients is a serious concern. Most of these patients need more than one topical antiglaucoma agent to control their intraocular pressures (IOPs). In the People's Republic of China, the daily cost of different glaucoma medication varies greatly, and the treatment habits differ throughout the country. Prostaglandin analogs (PGAs) are recommended as first-line monotherapy, because of their efficacy and low risk of systemic side effects. Fixed-combination drops, particularly PGA-based fixed combinations, have recently been developed and used in patients with progression or who have failed to achieve their target IOPs. Here, we reviewed the current literature on the use of bimatoprost-timolol fixed combination (BTFC) in the People's Republic of China. BTFC has achieved good efficacy and tolerability in Chinese clinical trials. In addition, BTFC is more cost effective compared with other fixed combinations available in the People's Republic of China. Fixed-combination drops may offer benefits, such as keeping the ocular surface healthy, convenience of administration, and improvement in long-term adherence and quality of life. Therefore, BTFC has great potential for the treatment of Chinese glaucoma patients. However, the long-term efficacy of BTFC, comparisons of BTFC with other fixed-combination drugs, and treatment adherence and persistence with treatment in Chinese patients are unknown and will require further study.

  17. Design and Implementation of Numerical Linear Algebra Algorithms on Fixed Point DSPs

    NASA Astrophysics Data System (ADS)

    Nikolić, Zoran; Nguyen, Ha Thai; Frantz, Gene

    2007-12-01

    Numerical linear algebra algorithms use the inherent elegance of matrix formulations and are usually implemented using C/C++ floating point representation. The system implementation is faced with practical constraints because these algorithms usually need to run in real time on fixed point digital signal processors (DSPs) to reduce total hardware costs. Converting the simulation model to fixed point arithmetic and then porting it to a target DSP device is a difficult and time-consuming process. In this paper, we analyze the conversion process. We transformed selected linear algebra algorithms from floating point to fixed point arithmetic, and compared real-time requirements and performance between the fixed point DSP and floating point DSP algorithm implementations. We also introduce an advanced code optimization and an implementation by DSP-specific, fixed point C code generation. By using the techniques described in the paper, speed can be increased by a factor of up to 10 compared to floating point emulation on fixed point hardware.

  18. Implementation Considerations for Automotive Vision Systems on a Fixed-Point DSP

    NASA Astrophysics Data System (ADS)

    Nikolić, Zoran

    In this chapter we evaluate numerical requirements for implementation of camera-based lateral position detection algorithms, such as lane keep assistant (LKA) and lane departure warning (LDW) on a fixed-point DSP. We first present methods that address the challenges and requirements of fixed-point design process. The flow proposed is targeted at converting C/C++ code with floating-point operations into C code with integer operations that can then be fed through the native C compiler for a fixed-point DSP. Advanced code optimization and an implementation by DSP-specific, fixed-point C code generation are introduced. We then demonstrate the conversion flow on tracking example (extended Kalman filter) using synthetically generated data, and we analyze trade-offs for algorithm implementation in fixed-point arithmetic. By using the techniques described in this chapter speed can be increased by a factor of up to 10 compared to floating-point emulation on fixed-point hardware.

  19. Parallel fixed point implementation of a radial basis function network in an FPGA.

    PubMed

    de Souza, Alisson C D; Fernandes, Marcelo A C

    2014-01-01

    This paper proposes a parallel fixed point radial basis function (RBF) artificial neural network (ANN), implemented in a field programmable gate array (FPGA) trained online with a least mean square (LMS) algorithm. The processing time and occupied area were analyzed for various fixed point formats. The problems of precision of the ANN response for nonlinear classification using the XOR gate and interpolation using the sine function were also analyzed in a hardware implementation. The entire project was developed using the System Generator platform (Xilinx), with a Virtex-6 xc6vcx240t-1ff1156 as the target FPGA.

  20. Parallel Fixed Point Implementation of a Radial Basis Function Network in an FPGA

    PubMed Central

    de Souza, Alisson C. D.; Fernandes, Marcelo A. C.

    2014-01-01

    This paper proposes a parallel fixed point radial basis function (RBF) artificial neural network (ANN), implemented in a field programmable gate array (FPGA) trained online with a least mean square (LMS) algorithm. The processing time and occupied area were analyzed for various fixed point formats. The problems of precision of the ANN response for nonlinear classification using the XOR gate and interpolation using the sine function were also analyzed in a hardware implementation. The entire project was developed using the System Generator platform (Xilinx), with a Virtex-6 xc6vcx240t-1ff1156 as the target FPGA. PMID:25268918

  1. Fixed-Cell Imaging of Schizosaccharomyces pombe.

    PubMed

    Hagan, Iain M; Bagley, Steven

    2016-01-01

    The acknowledged genetic malleability of fission yeast has been matched by impressive cytology to drive major advances in our understanding of basic molecular cell biological processes. In many of the more recent studies, traditional approaches of fixation followed by processing to accommodate classical staining procedures have been superseded by live-cell imaging approaches that monitor the distribution of fusion proteins between a molecule of interest and a fluorescent protein. Although such live-cell imaging is uniquely informative for many questions, fixed-cell imaging remains the better option for others and is an important-sometimes critical-complement to the analysis of fluorescent fusion proteins by live-cell imaging. Here, we discuss the merits of fixed- and live-cell imaging as well as specific issues for fluorescence microscopy imaging of fission yeast. PMID:27371603

  2. Fixed-rate layered multicast congestion control

    NASA Astrophysics Data System (ADS)

    Bing, Zhang; Bing, Yuan; Zengji, Liu

    2006-10-01

    A new fixed-rate layered multicast congestion control algorithm called FLMCC is proposed. The sender of a multicast session transmits data packets at a fixed rate on each layer, while receivers each obtain different throughput by cumulatively subscribing to deferent number of layers based on their expected rates. In order to provide TCP-friendliness and estimate the expected rate accurately, a window-based mechanism implemented at receivers is presented. To achieve this, each receiver maintains a congestion window, adjusts it based on the GAIMD algorithm, and from the congestion window an expected rate is calculated. To measure RTT, a new method is presented which combines an accurate measurement with a rough estimation. A feedback suppression based on a random timer mechanism is given to avoid feedback implosion in the accurate measurement. The protocol is simple in its implementation. Simulations indicate that FLMCC shows good TCP-friendliness, responsiveness as well as intra-protocol fairness, and provides high link utilization.

  3. Earth stations for fixed and mobile services

    NASA Astrophysics Data System (ADS)

    Charyk, J. V.; Metzger, S.

    1984-07-01

    Communication service provided with the aid of commercial satellites began 18 years ago with the launch of Early Bird (Inselsat I). The present investigation is concerned with the evolution of the earth stations used in the Intelsat system, taking into account the technical, political, and operational factors which have influenced the design of the stations. The success of the Intelsat system led to the use of communication satellites for domestic, maritime, and direct broadcast use. More than 2000 commercial ships communicate via satellite, and by the end of the 1980s, there should be missions of home receivers for direct broadcast satellite television reception. Fixed international service stations are discussed, taking into account overall considerations, antennas, high power amplifiers, low noise amplifiers, multiplex systems, and small earth stations. Attention is also given to fixed domestic service stations, direct broadcast stations, and maritime service.

  4. Fixed flexion deformity and total knee arthroplasty.

    PubMed

    Su, E P

    2012-11-01

    Fixed flexion deformities are common in osteoarthritic knees that are indicated for total knee arthroplasty. The lack of full extension at the knee results in a greater force of quadriceps contracture and energy expenditure. It also results in slower walking velocity and abnormal gait mechanics, overloading the contralateral limb. Residual flexion contractures after TKA have been associated with poorer functional scores and outcomes. Although some flexion contractures may resolve with time after surgery, a substantial percentage will become permanent. Therefore, it is essential to correct fixed flexion deformities at the time of TKA, and be vigilant in the post-operative course to maintain the correction. Surgical techniques to address pre-operative flexion contractures include: adequate bone resection, ligament releases, removal of posterior osteophytes, and posterior capsular releases. Post-operatively, extension can be maintained with focused physiotherapy, a specially modified continuous passive motion machine, a contralateral heel lift, and splinting.

  5. Integrating fixed and removable provisional restorations.

    PubMed

    Curtis, S R

    1993-10-01

    When both fixed and removable components are required, provisional restorations can be difficult. This article describes a technique where provisional restoration "shells" are made with a plastic stent of the diagnostic wax-up on lightly prepared teeth of a diagnostic cast. An acrylic removable partial denture is then waxed to the shells. The shells are relined intraorally after tooth preparation with the partial denture in place.

  6. Coating removal systems - Mobile or fixed?

    NASA Astrophysics Data System (ADS)

    Mangold, Vernon L., Jr.

    1992-04-01

    Various coating removal technologies are discussed from the viewpoint of the process and delivery, with emphasis placed on the mobile Large Aircraft Robot Paint Stripping (LARPS) concept. LARPS is a combined and integrated package of a delivery system and the process media, representing the alternative to the fixed-frame or gantry robot style delivery systems. The paper describes details of the LARPS system design and performance, and presents design diagrams of LARPS.

  7. Fixed drug eruptions with intraoral presentation

    PubMed Central

    Srivastava, Rahul; Bihari, Manorama; Bhuvan, Jyoti; Saad, Ahmed

    2015-01-01

    Fixed-drug eruption (FDE) is an unusual and rare adverse drug reaction. This type of reaction is actually a delayed type of hypersensitivity reaction that occurs as lesions recurring at the same skin site due to repeated intake of an offending drug. Here is a case report of a 58-year-old male patient who developed intraoral FDEs after ingestion of the first dose of ornidazole. PMID:26097341

  8. Fixed-combination and emerging glaucoma therapies.

    PubMed

    Woodward, David F; Chen, June

    2007-05-01

    Ocular hypotensive agents are the only approved pharmacotherapy for glaucoma. Despite significant advances during the past two decades, a large proportion of glaucoma patients require more than one drug. The most recent additions to the armamentarium of antiglaucoma drugs are fixed-combination products for the glaucoma patient who is insufficiently responsive to monotherapy. Fixed-combination products have the combined efficacy of two ocular hypotensive drugs, and the convenience of a two-drug treatment regimen in a single container, which may aid patient adherence to treatment. Available fixed-combination products consist of timolol 0.5% as an invariant with brimonidine 0.2%, dorzolamide 2%, travoprost 0.004%, latanoprost 0.005% or bimatoprost 0.03%. Research on more advanced antiglaucoma medications continues. Promising new directions appear to be the Rho-kinase inhibitors, microtubule-disrupting agents, serotonergics and cannabimimetics. Efforts continue to improve existing antiglaucoma drugs in an attempt to design second-generation cholinomimetics, adrenergics, prostaglandins and prostamides. PMID:17604504

  9. Zirconia in fixed prosthesis. A literature review

    PubMed Central

    Román-Rodríguez, Juan L.; Ferreiroa, Alberto; Solá-Ruíz, María F.; Fons-Font, Antonio

    2014-01-01

    Statement of problem: Evidence is limited on the efficacy of zirconia-based fixed dental prostheses. Objective: To carry out a literature review of the behavior of zirconium oxide dental restorations. Material and Methods: This literature review searched the Pubmed, Scopus, Medline and Cochrane Library databases using key search words “zirconium oxide,” “zirconia,” “non-metal restorations,” “ceramic oxides,” “veneering ceramic,” “zirconia-based fixed dental prostheses”. Both in vivo and in vitro studies into zirconia-based prosthodontic restoration behavior were included. Results: Clinical studies have revealed a high rate of fracture for porcelain-veneered zirconia-based restorations that varies between 6% and 15% over a 3- to 5-year period, while for ceramo-metallic restorations the fracture rate ranges between 4 and 10% over ten years. These results provoke uncertainty as to the long-term prognosis for this material in the oral medium. The cause of veneering porcelain fractures is unknown but hypothetically they could be associated with bond failure between the veneer material and the zirconia sub-structure. Key words:Veneering ceramic, zirconia-based ceramic restoration, crown, zirconia, tooth-supported fixed prosthesis. PMID:24596638

  10. RSRM nozzle fixed housing cooldown test

    NASA Technical Reports Server (NTRS)

    Bolieau, D. J.

    1989-01-01

    Flight 5 aft segments with nozzles were exposed to -17 F temperatures while awaiting shipment to KSC in February, 1989. No records were found which show that any previous nozzles were exposed to air temperatures as low as those seen by the Flight 5 nozzles. Thermal analysis shows that the temperature of the fixed housing, and forward and aft exit cone components dropped as low as -10 F. Structural analysis of the nozzles at these low temperatures show the forward and aft exit cone adhesive bonds to have a positive margin of safety, based on a 2.0 safety factor. These analyses show the normal and shear stresses in the fixed housing bond as low values. However, the hoop and meridinal stresses were predicted to be in the 4000 psi range; the failure stress allowable of EA913NA adhesive at -7 F. If the bonds did break in directions perpendicular to the surfaces, called bond crazing, no normal bond strength would be lost. Testing was conducted in two phases, showing that no degradation to the adhesive bonds occurred while the Flight 5 nozzles were subjected to subzero temperatures. The results of these tests are documented. Phase 1 testing cooled a full-scale RSRM insulated fixed housing to -13 F, with extensive bondline inspections. Phase 2 testing cooled the witness panel adhesive tensile buttions to -13 F, with failure strengths recorded before, during, and after the cooldown.

  11. Auditory target detection in reverberation

    NASA Astrophysics Data System (ADS)

    Zurek, Patrick M.; Freyman, Richard L.; Balakrishnan, Uma

    2004-04-01

    Measurements and theoretical predictions of auditory target detection in simulated reverberant conditions are reported. The target signals were pulsed 13-octave bands of noise and the masker signal was a continuous wideband noise. Target and masker signals were passed through a software simulation of a reverberant room with a rigid sphere modeling a listener's head. The location of the target was fixed while the location of the masker was varied in the simulated room. Degree of reverberation was controlled by varying the uniform acoustic absorption of the simulated room's surfaces. The resulting target and masker signals were presented to the listeners over headphones in monaural-left, monaural-right, or binaural listening modes. Changes in detection performance in the monaural listening modes were largely predictable from the changes in target-to-masker ratio in the target band, but with a few dB of extra masking in reverberation. Binaural detection performance was generally well predicted by applying Durlach's [in Foundations of Modern Auditory Theory (Academic, New York, 1972)] equalization-cancellation theory to the direct-plus-reverberant ear signals. Predictions in all cases were based on a statistical description of room acoustics and on acoustic diffraction by a sphere. The success of these detection models in the present well-controlled reverberant conditions suggests that they can be used to incorporate listening mode and source location as factors in speech-intelligibility predictions.

  12. Synthetic aperture radar target simulator

    NASA Technical Reports Server (NTRS)

    Zebker, H. A.; Held, D. N.; Goldstein, R. M.; Bickler, T. C.

    1984-01-01

    A simulator for simulating the radar return, or echo, from a target seen by a SAR antenna mounted on a platform moving with respect to the target is described. It includes a first-in first-out memory which has digital information clocked in at a rate related to the frequency of a transmitted radar signal and digital information clocked out with a fixed delay defining range between the SAR and the simulated target, and at a rate related to the frequency of the return signal. An RF input signal having a frequency similar to that utilized by a synthetic aperture array radar is mixed with a local oscillator signal to provide a first baseband signal having a frequency considerably lower than that of the RF input signal.

  13. Tackling Targets.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    This document is designed to help British training and enterprise councils (TECs) and further education (FE) colleges develop and implement strategies for achieving the National Targets for Education and Training (NTET), which were developed by the Confederation of British Industry in 1992 and endorsed by the British government. The findings from…

  14. Metabolic syndrome in fixed-shift workers

    PubMed Central

    Canuto, Raquel; Pattussi, Marcos Pascoal; Macagnan, Jamile Block Araldi; Henn, Ruth Liane; Olinto, Maria Teresa Anselmo

    2015-01-01

    OBJECTIVE To analyze if metabolic syndrome and its altered components are associated with demographic, socioeconomic and behavioral factors in fixed-shift workers. METHODS A cross-sectional study was conducted on a sample of 902 shift workers of both sexes in a poultry processing plant in Southern Brazil in 2010. The diagnosis of metabolic syndrome was determined according to the recommendations from Harmonizing the Metabolic Syndrome. Its frequency was evaluated according to the demographic (sex, skin color, age and marital status), socioeconomic (educational level, income and work shift), and behavioral characteristics (smoking, alcohol intake, leisure time physical activity, number of meals and sleep duration) of the sample. The multivariate analysis followed a theoretical framework for identifying metabolic syndrome in fixed-shift workers. RESULTS The prevalence of metabolic syndrome in the sample was 9.3% (95%CI 7.4;11.2). The most frequently altered component was waist circumference (PR 48.4%; 95%CI 45.5;51.2), followed by high-density lipoprotein. Work shift was not associated with metabolic syndrome and its altered components. After adjustment, the prevalence of metabolic syndrome was positively associated with women (PR 2.16; 95%CI 1.28;3.64), workers aged over 40 years (PR 3.90; 95%CI 1.78;8.93) and those who reported sleeping five hours or less per day (PR 1.70; 95%CI 1.09;2.24). On the other hand, metabolic syndrome was inversely associated with educational level and having more than three meals per day (PR 0.43; 95%CI 0.26;0.73). CONCLUSIONS Being female, older and deprived of sleep are probable risk factors for metabolic syndrome, whereas higher educational level and higher number of meals per day are protective factors for metabolic syndrome in fixed-shift workers. PMID:26061455

  15. Quorum Sensing in Nitrogen-Fixing Rhizobia

    PubMed Central

    González, Juan E.; Marketon, Melanie M.

    2003-01-01

    Members of the rhizobia are distinguished for their ability to establish a nitrogen-fixing symbiosis with leguminous plants. While many details of this relationship remain a mystery, much effort has gone into elucidating the mechanisms governing bacterium-host recognition and the events leading to symbiosis. Several signal molecules, including plant-produced flavonoids and bacterially produced nodulation factors and exopolysaccharides, are known to function in the molecular conversation between the host and the symbiont. Work by several laboratories has shown that an additional mode of regulation, quorum sensing, intercedes in the signal exchange process and perhaps plays a major role in preparing and coordinating the nitrogen-fixing rhizobia during the establishment of the symbiosis. Rhizobium leguminosarum, for example, carries a multitiered quorum-sensing system that represents one of the most complex regulatory networks identified for this form of gene regulation. This review focuses on the recent stream of information regarding quorum sensing in the nitrogen-fixing rhizobia. Seminal work on the quorum-sensing systems of R. leguminosarum bv. viciae, R. etli, Rhizobium sp. strain NGR234, Sinorhizobium meliloti, and Bradyrhizobium japonicum is presented and discussed. The latest work shows that quorum sensing can be linked to various symbiotic phenomena including nodulation efficiency, symbiosome development, exopolysaccharide production, and nitrogen fixation, all of which are important for the establishment of a successful symbiosis. Many questions remain to be answered, but the knowledge obtained so far provides a firm foundation for future studies on the role of quorum-sensing mediated gene regulation in host-bacterium interactions. PMID:14665677

  16. Impaired Inhibitory Force Feedback in Fixed Dystonia.

    PubMed

    Mugge, Winfred; Schouten, Alfred C; van Hilten, Jacobus J; van der Helm, Frans C T

    2016-04-01

    Complex regional pain syndrome (CRPS) is a multifactorial disorder associated with an aberrant host response to tissue injury. About 25% of CRPS patients suffer poorly understood involuntary sustained muscle contractions associated with dysfunctional reflexes that result in abnormal postures (fixed dystonia). A recent modeling study simulated fixed dystonia (FD) caused by aberrant force feedback. The current study aims to validate this hypothesis by experimentally recording the modulation of reflexive force feedback in patients with FD. CRPS patients with and without FD, patients with FD but without CRPS, as well as healthy controls participated in the experiment. Three task instructions and three perturbation characteristics were used to evoke a wide range of responses to force perturbations. During position tasks ("maintain posture"), healthy subjects as well as patients resisted the perturbations, becoming more stiff than when being relaxed (i.e., the relax task). Healthy subjects and CRPS patients without FD were both more compliant during force tasks ("maintain force") than during relax tasks, meaning they actively gave way to the imposed forces. Remarkably, the patients with FD failed to do so. A neuromuscular model was fitted to the experimental data to separate the distinct contributions of position, velocity and force feedback, as well as co-contraction to the motor behavior. The neuromuscular modeling indicated that inhibitory force feedback is deregulated in patients with FD, for both CRPS and non-CRPS patients. From previously published simulation results and the present experimental study, it is concluded that aberrant force feedback plays a role in fixed dystonia. PMID:25955788

  17. Detection in fixed and random noise in foveal and parafoveal vision explained by template learning

    NASA Technical Reports Server (NTRS)

    Beard, B. L.; Ahumada, A. J. Jr; Watson, A. B. (Principal Investigator)

    1999-01-01

    Foveal and parafoveal contrast detection thresholds for Gabor and checkerboard targets were measured in white noise by means of a two-interval forced-choice paradigm. Two white-noise conditions were used: fixed and twin. In the fixed noise condition a single noise sample was presented in both intervals of all the trials. In the twin noise condition the same noise sample was used in the two intervals of a trial, but a new sample was generated for each trial. Fixed noise conditions usually resulted in lower thresholds than twin noise. Template learning models are presented that attribute this advantage of fixed over twin noise either to fixed memory templates' reducing uncertainty by incorporation of the noise or to the introduction, by the learning process itself, of more variability in the twin noise condition. Quantitative predictions of the template learning process show that it contributes to the accelerating nonlinear increase in performance with signal amplitude at low signal-to-noise ratios.

  18. Colligative Properties of Solutions: I. Fixed Concentrations

    NASA Astrophysics Data System (ADS)

    Alexander, Kenneth S.; Biskup, Marek; Chayes, Lincoln

    2005-05-01

    Using the formalism of rigorous statistical mechanics, we study the phenomena of phase separation and freezing-point depression upon freezing of solutions. Specifically, we devise an Ising-based model of a solvent--solute system and show that, in the ensemble with a fixed amount of solute, a macroscopic phase separation occurs in an interval of values of the chemical potential of the solvent. The boundaries of the phase separation domain in the phase diagram are characterized and shown to asymptotically agree with the formulas used in heuristic analyses of freezing-point depression. The limit of infinitesimal concentrations is described in a subsequent paper.

  19. Finally, fixing health care: what's different now?

    PubMed

    Wyden, Ron; Bennett, Bob

    2008-01-01

    Is now the time to fix the U.S. health care system? Those who remember the failed attempts of the past would say no. We see it differently. Our optimism is rooted in new developments that didn't exist the last time Congress addressed health care. These include bipartisan support for our Healthy Americans Act; an ideological truce over the role of government in health care; common ground between business and labor; the realization that states can't go it alone on health care; the plight of employers in a global marketplace; and the need for coverage that is affordable, accessible, and portable.

  20. Fixed drug eruption due to methaqualone.

    PubMed

    Slazinski, L; Knox, D W

    1984-08-01

    We report three cases of fixed drug eruption due to methaqualone. Eruptions from methaqualone have been rarely reported since the drug's introduction in 1963. Our discovery of these three cases during a two-year period suggests that dermatologic reactions from methaqualone may be much more common than has been appreciated. This may be related to the reluctance of the patient to admit to the use or abuse of methaqualone, and physicians' lack of recognition of the widespread abuse of this drug and its possible cutaneous complications.

  1. [Fixed appliances current state of the art].

    PubMed

    Droschl, H; Eskici, A; Bantleon, H P; Muchitsch, A P

    1989-11-01

    Recent advances in fixed appliances are reviewed and discussed. These include cosmetically more appealing brackets (ceramic, lingual); new wires (nickel-titanium and titanium-molybdenum alloys); new biomechanical approaches (accurate computation of forces and torques according to Burstone resulting in the use of new mechanical concepts); experiences in the treatment of transplanted teeth made in the past 15 years; new approaches to the orthodontic finish (implementation of Andrews' "six keys to normal occlusion" with straight wires, accurate positioning of brackets, and gnathological positioners). Cases will be demonstrated.

  2. Critical two-dimensional Ising model with free, fixed ferromagnetic, fixed antiferromagnetic, and double antiferromagnetic boundaries.

    PubMed

    Wu, Xintian; Izmailyan, Nickolay

    2015-01-01

    The critical two-dimensional Ising model is studied with four types boundary conditions: free, fixed ferromagnetic, fixed antiferromagnetic, and fixed double antiferromagnetic. Using bond propagation algorithms with surface fields, we obtain the free energy, internal energy, and specific heat numerically on square lattices with a square shape and various combinations of the four types of boundary conditions. The calculations are carried out on the square lattices with size N×N and 30

  3. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  4. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  5. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  6. Target assembly

    DOEpatents

    Lewis, Richard A.

    1980-01-01

    A target for a proton beam which is capable of generating neutrons for absorption in a breeding blanket includes a plurality of solid pins formed of a neutron emissive target material disposed parallel to the path of the beam and which are arranged axially in a plurality of layers so that pins in each layer are offset with respect to pins in all other layers, enough layers being used so that each proton in the beam will strike at least one pin with means being provided to cool the pins. For a 300 mA, 1 GeV beam (300 MW), stainless steel pins, 12 inches long and 0.23 inches in diameter are arranged in triangular array in six layers with one sixth of the pins in each layer, the number of pins being such that the entire cross sectional area of the beam is covered by the pins with minimum overlap of pins.

  7. Experimental Study on Nonlinear Vibrations of Fixed-Fixed Curved Beams

    NASA Astrophysics Data System (ADS)

    Kumar, Ajay; Patel, B. P.

    2016-07-01

    Nonlinear dynamic behavior of fixed-fixed shallow and deep curved beams is studied experimentally using non-contact type of electromagnetic shaker and acceleration measurements. The frequency response obtained from acceleration measurements is found to be in fairly good agreement with the computational response. The travellingwave phenomenon along with participation of higher harmonics and softening nonlinearity are observed. The experimental results on the internal resonance of curved beams due to direct excitation of anti-symmetric mode are reported for the first time. The deep curved beam depicts chaotic response at higher excitation amplitude.

  8. Fixed Drug Eruption due to Achiote Dye.

    PubMed

    Tattersall, Ian; Reddy, Bobby Y

    2016-01-01

    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing.

  9. Fixed Drug Eruption due to Achiote Dye

    PubMed Central

    Tattersall, Ian; Reddy, Bobby Y.

    2016-01-01

    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing. PMID:26933409

  10. Fixed-dose combination therapy for psoriasis.

    PubMed

    Guenther, Lyn C

    2004-01-01

    Fixed-dose combination therapy offers stable products containing two or more medications with different mechanisms of action and safety profiles. It is also convenient for patients since only one product rather than two or more needs to be applied. Topical corticosteroids are often the mainstay of therapy in psoriasis. Diprosalic and Nerisalic contain a topical corticosteroid (betamethasone dipropionate and diflucortolone, respectively) and salicylic acid. A left/right study showed that both products have comparable efficacy. It has also been shown that betamethasone dipropionate + salicylic acid ointment has similar efficacy to clobetasol and calcipotriene (calcipotriol) ointments. Betamethasone dipropionate + salicylic acid lotion has similar efficacy to clobetasol lotion. Faster improvement of scaling, itching, and redness was noted with betamethasone dipropionate + salicylic acid lotion compared with betamethasone dipropionate alone. Dovobet (Daivobet) ointment is a fixed-dose combination product containing betamethasone dipropionate and calcipotriene. Clinical studies have shown that it has greater efficacy and a faster speed of onset than the individual components or tacalcitol. Once daily and twice daily treatments have similar efficacy. Psoriasis Area and Severity Index reductions of approximately 40% after 1 week and 70% after 4 weeks of therapy were consistently noted in six large international studies involving >6000 patients. Betamethasone dipropionate + calcipotriene treatment is associated with approximately 75% less adverse cutaneous events as compared with tacalcitol, 50% less compared with calcipotriene, and a similar number as treatment with betamethasone dipropionate.

  11. Fixed Drug Eruption due to Achiote Dye.

    PubMed

    Tattersall, Ian; Reddy, Bobby Y

    2016-01-01

    Fixed drug eruption (FDE) is a localized type IV sensitivity reaction to a systemically introduced allergen. It usually occurs as a result of new medication, making identification and avoidance of the trigger medication straightforward; however, in a rare subset of cases no pharmacological source is identified. In such cases, the causative agent is often a food or food additive. In this report we describe a case of a FDE in a 12-year-old girl recently immigrated to the United States from Ecuador who had no medication exposure over the course of her illness. Through an exhaustive patient history and literature review, we were able to hypothesize that her presentation was caused by a dietary change of the natural achiote dye used in the preparation of yellow rice to a locally available commercial dye mix containing tartrazine, or Yellow 5, which has previously been implicated in both systemic hypersensitivity reactions and specifically in FDE. This report adds to the small body of available literature on non-pharmacological fixed hypersensitivity eruptions and illustrates an effective approach to the management of such a presentation when history is not immediately revealing. PMID:26933409

  12. Fixed-dose combination therapy for psoriasis.

    PubMed

    Guenther, Lyn C

    2004-01-01

    Fixed-dose combination therapy offers stable products containing two or more medications with different mechanisms of action and safety profiles. It is also convenient for patients since only one product rather than two or more needs to be applied. Topical corticosteroids are often the mainstay of therapy in psoriasis. Diprosalic and Nerisalic contain a topical corticosteroid (betamethasone dipropionate and diflucortolone, respectively) and salicylic acid. A left/right study showed that both products have comparable efficacy. It has also been shown that betamethasone dipropionate + salicylic acid ointment has similar efficacy to clobetasol and calcipotriene (calcipotriol) ointments. Betamethasone dipropionate + salicylic acid lotion has similar efficacy to clobetasol lotion. Faster improvement of scaling, itching, and redness was noted with betamethasone dipropionate + salicylic acid lotion compared with betamethasone dipropionate alone. Dovobet (Daivobet) ointment is a fixed-dose combination product containing betamethasone dipropionate and calcipotriene. Clinical studies have shown that it has greater efficacy and a faster speed of onset than the individual components or tacalcitol. Once daily and twice daily treatments have similar efficacy. Psoriasis Area and Severity Index reductions of approximately 40% after 1 week and 70% after 4 weeks of therapy were consistently noted in six large international studies involving >6000 patients. Betamethasone dipropionate + calcipotriene treatment is associated with approximately 75% less adverse cutaneous events as compared with tacalcitol, 50% less compared with calcipotriene, and a similar number as treatment with betamethasone dipropionate. PMID:15109271

  13. [Fiber-reinforced composite in fixed prosthodontics].

    PubMed

    Pilo, R; Abu Rass, Z; Shmidt, A

    2010-07-01

    Fiber reinforced composite (FRC) is composed of resin matrix and fibers filler. Common types of fibers: polyethylene, carbon and glass. Fibers can be continuous and aligned, discontinuous and aligned, discontinuous and randomly oriented. The architecture of the fibers is unidirectional, woven or braided. The two main types are: dry fibers or impregnated. Inclusion of fibers to resin composite increased its average flexural strength in 100-200 MPa. FRC can be utilized by the dentist in direct approach (splinting, temporary winged bridge) or indirect approach (laboratory made fixed partial denture). Laboratory fixed partial denture (FPD) is made from FRC substructure and Hybrid/Microfill particulate composite veneer. Main indications: interim temporary FPD or FPD in cases of questionable abutment teeth, in aesthetic cases where All Ceram FPD is not feasible. Retention is attained by adhesive cementation to minimally prepared teeth or to conventionally prepared teeth; other options are inlay-onlay bridges or hybrid bridges. Contraindications are: poor hygiene, inability to control humidity, parafunction habits, and more than two pontics. Survival rate of FRC FPD over 5 years is 75%, lower compared to porcelain fused to metal FPD which is 95%. Main reasons for failure are: fracture of framework and delamination of the veneer. Part of the failures is repairable. PMID:21485555

  14. [Fiber-reinforced composite in fixed prosthodontics].

    PubMed

    Pilo, R; Abu Rass, Z; Shmidt, A

    2010-07-01

    Fiber reinforced composite (FRC) is composed of resin matrix and fibers filler. Common types of fibers: polyethylene, carbon and glass. Fibers can be continuous and aligned, discontinuous and aligned, discontinuous and randomly oriented. The architecture of the fibers is unidirectional, woven or braided. The two main types are: dry fibers or impregnated. Inclusion of fibers to resin composite increased its average flexural strength in 100-200 MPa. FRC can be utilized by the dentist in direct approach (splinting, temporary winged bridge) or indirect approach (laboratory made fixed partial denture). Laboratory fixed partial denture (FPD) is made from FRC substructure and Hybrid/Microfill particulate composite veneer. Main indications: interim temporary FPD or FPD in cases of questionable abutment teeth, in aesthetic cases where All Ceram FPD is not feasible. Retention is attained by adhesive cementation to minimally prepared teeth or to conventionally prepared teeth; other options are inlay-onlay bridges or hybrid bridges. Contraindications are: poor hygiene, inability to control humidity, parafunction habits, and more than two pontics. Survival rate of FRC FPD over 5 years is 75%, lower compared to porcelain fused to metal FPD which is 95%. Main reasons for failure are: fracture of framework and delamination of the veneer. Part of the failures is repairable.

  15. 29 CFR 1910.162 - Fixed extinguishing systems, gaseous agent.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Fixed extinguishing systems, gaseous agent. 1910.162 Section 1910.162 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Fixed Fire Suppression Equipment § 1910.162 Fixed...

  16. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  17. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  18. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  19. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  20. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  1. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  2. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  3. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  4. 46 CFR 130.320 - Electronic position-fixing device.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Electronic position-fixing device. 130.320 Section 130... CONTROL, AND MISCELLANEOUS EQUIPMENT AND SYSTEMS Navigational Equipment § 130.320 Electronic position-fixing device. Each vessel must be equipped with an electronic position-fixing device satisfactory...

  5. 46 CFR 121.410 - Electronic position fixing devices.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Electronic position fixing devices. 121.410 Section 121... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Navigation Equipment § 121.410 Electronic position fixing devices. A vessel on an oceans route must be equipped with an electronic position fixing device,...

  6. 47 CFR 15.307 - Coordination with fixed microwave service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Coordination with fixed microwave service. 15... Unlicensed Personal Communications Service Devices § 15.307 Coordination with fixed microwave service. (a... Private Operational-Fixed Microwave Service (OFS) operating under part 101 of this chapter to...

  7. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  8. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  9. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  10. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  11. 47 CFR 101.125 - Temporary fixed antenna height restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Temporary fixed antenna height restrictions... SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.125 Temporary fixed antenna height restrictions. The overall antenna structure heights employed by mobile stations in the...

  12. 30 CFR 57.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Inclined fixed ladders. 57.11017 Section 57.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11017 Inclined fixed ladders. Fixed ladders shall...

  13. 30 CFR 57.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Fixed ladder landings. 57.11006 Section 57.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11006 Fixed ladder landings. Fixed ladders shall...

  14. 30 CFR 57.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Inclined fixed ladders. 57.11017 Section 57.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11017 Inclined fixed ladders. Fixed ladders shall...

  15. 30 CFR 56.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Fixed ladder landings. 56.11006 Section 56.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11006 Fixed ladder landings. Fixed ladders shall project at least 3 feet above landings, or...

  16. 30 CFR 56.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Protection for inclined fixed ladders. 56.11026... § 56.11026 Protection for inclined fixed ladders. Fixed ladders 70 degrees to 90 degrees from the... point not more than seven feet from the bottom of the ladders....

  17. 30 CFR 56.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Inclined fixed ladders. 56.11017 Section 56.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11017 Inclined fixed ladders. Fixed ladders shall not incline backwards....

  18. 30 CFR 57.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Fixed ladder landings. 57.11006 Section 57.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11006 Fixed ladder landings. Fixed ladders shall...

  19. 30 CFR 56.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Inclined fixed ladders. 56.11017 Section 56.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11017 Inclined fixed ladders. Fixed ladders shall not incline backwards....

  20. 30 CFR 56.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Fixed ladder landings. 56.11006 Section 56.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11006 Fixed ladder landings. Fixed ladders shall project at least 3 feet above landings, or...

  1. 30 CFR 56.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection for inclined fixed ladders. 56.11026... § 56.11026 Protection for inclined fixed ladders. Fixed ladders 70 degrees to 90 degrees from the... point not more than seven feet from the bottom of the ladders....

  2. 46 CFR 28.320 - Fixed gas fire extinguishing systems.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Fixed gas fire extinguishing systems. 28.320 Section 28..., 1991, and That Operate With More Than 16 Individuals on Board § 28.320 Fixed gas fire extinguishing...) or more in length must be fitted with a fixed gas fire extinguishing system in the following...

  3. 46 CFR 28.320 - Fixed gas fire extinguishing systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Fixed gas fire extinguishing systems. 28.320 Section 28..., 1991, and That Operate With More Than 16 Individuals on Board § 28.320 Fixed gas fire extinguishing...) or more in length must be fitted with a fixed gas fire extinguishing system in the following...

  4. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fixed extinguishing system, general. 169.564 Section 169... VESSELS Lifesaving and Firefighting Equipment Firefighting Equipment § 169.564 Fixed extinguishing system, general. (a) Fixed carbon dioxide or halogenated extinguishing systems must be installed to protect...

  5. 30 CFR 56.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Fixed ladder landings. 56.11006 Section 56.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11006 Fixed ladder landings. Fixed ladders shall project at least 3 feet above landings, or...

  6. 48 CFR 1816.202 - Firm-fixed-price contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Firm-fixed-price contracts... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202 Firm-fixed-price contracts....

  7. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Temporary fixed stations. 22.1031 Section 22... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  8. 34 CFR 76.566 - Fixed costs-restricted rate.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Fixed costs-restricted rate. 76.566 Section 76.566... Be Met by the State and Its Subgrantees? Indirect Cost Rates § 76.566 Fixed costs—restricted rate. As used in § 76.564, fixed costs means contributions of the grantee to fringe benefits and similar...

  9. 30 CFR 57.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Fixed ladder landings. 57.11006 Section 57.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11006 Fixed ladder landings. Fixed ladders shall...

  10. 30 CFR 56.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Protection for inclined fixed ladders. 56.11026 Section 56.11026 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... § 56.11026 Protection for inclined fixed ladders. Fixed ladders 70 degrees to 90 degrees from...

  11. 30 CFR 56.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Fixed ladder landings. 56.11006 Section 56.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11006 Fixed ladder landings. Fixed ladders shall project at least 3 feet above landings, or...

  12. 48 CFR 46.304 - Fixed-price service contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Fixed-price service... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.304 Fixed-price service contracts. The contracting officer shall insert the clause at 52.246-4, Inspection of Services—Fixed-Price, in...

  13. 48 CFR 970.1504-1-6 - Calculating fixed fee.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Calculating fixed fee. 970... Calculating fixed fee. (a) In recognition of the complexities of the fee determination process, and to assist... particular fixed fee transaction calculated annually. (b) Fee schedules representing the maximum...

  14. 46 CFR 108.631 - Fixed fire extinguishing system controls.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Fixed fire extinguishing system controls. 108.631... DRILLING UNITS DESIGN AND EQUIPMENT Equipment Markings and Instructions § 108.631 Fixed fire extinguishing system controls. (a) Each cabinet or space that contains a valve, control, or manifold of a fixed...

  15. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Hand-operated fixed derails. 218.109 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  16. 40 CFR 63.1042 - Standards-Separator fixed roof.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Standards-Separator fixed roof. 63...—Separator fixed roof. (a) This section applies to owners and operators subject to this subpart and controlling air emissions from an oil-water separator or organic-water separator using a fixed roof. (b)...

  17. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Temporary fixed stations. 22.1031 Section 22... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  18. 46 CFR 95.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fixed fire extinguishing systems. 95.05-10 Section 95.05... FIRE PROTECTION EQUIPMENT Fire Detecting and Extinguishing Equipment, Where Required § 95.05-10 Fixed... barges with sleeping accommodations for more than 12 persons. (b) A fixed carbon dioxide or...

  19. 47 CFR 80.381 - Frequencies for operational fixed stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Frequencies for operational fixed stations. 80... RADIO SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Operational Fixed Stations § 80.381 Frequencies for operational fixed stations. The following carrier frequencies in the 72-76 MHz band...

  20. 12 CFR 701.36 - FCU ownership of fixed assets.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false FCU ownership of fixed assets. 701.36 Section... ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.36 FCU ownership of fixed assets. (a) Investment in Fixed Assets. (1) No Federal credit union with $1,000,000 or more in assets may invest in any...

  1. 48 CFR 46.304 - Fixed-price service contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price service... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.304 Fixed-price service contracts. The contracting officer shall insert the clause at 52.246-4, Inspection of Services—Fixed-Price, in...

  2. 34 CFR 76.566 - Fixed costs-restricted rate.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Fixed costs-restricted rate. 76.566 Section 76.566... Be Met by the State and Its Subgrantees? Indirect Cost Rates § 76.566 Fixed costs—restricted rate. As used in § 76.564, fixed costs means contributions of the grantee to fringe benefits and similar...

  3. 48 CFR 31.102 - Fixed-price contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price contracts. 31... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Applicability 31.102 Fixed-price contracts. The applicable subparts of part 31 shall be used in the pricing of fixed-price contracts,...

  4. 30 CFR 56.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Inclined fixed ladders. 56.11017 Section 56.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11017 Inclined fixed ladders. Fixed ladders shall not incline backwards....

  5. 47 CFR 90.557 - Secondary fixed signaling operations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Secondary fixed signaling operations. 90.557... the 763-775 and 793-805 MHz Bands § 90.557 Secondary fixed signaling operations. Trunked and conventional 700 MHz narrowband systems may conduct fixed ancillary signaling and data transmissions subject...

  6. 48 CFR 46.304 - Fixed-price service contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price service... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.304 Fixed-price service contracts. The contracting officer shall insert the clause at 52.246-4, Inspection of Services—Fixed-Price, in...

  7. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  8. 2 CFR 200.332 - Fixed amount subawards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Fixed amount subawards. 200.332 Section 200....332 Fixed amount subawards. With prior written approval from the Federal awarding agency, a pass-through entity may provide subawards based on fixed amounts up to the Simplified Acquisition...

  9. 30 CFR 57.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Inclined fixed ladders. 57.11017 Section 57.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11017 Inclined fixed ladders. Fixed ladders shall...

  10. 29 CFR 1910.162 - Fixed extinguishing systems, gaseous agent.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Fixed extinguishing systems, gaseous agent. 1910.162... ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Fixed Fire Suppression Equipment § 1910.162 Fixed extinguishing systems, gaseous agent. (a) Scope and...

  11. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.114 Fixed... that he will receive such fixed amount as straight time pay for whatever hours he is called upon...

  12. 48 CFR 1828.370 - Fixed-price contract clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Fixed-price contract... ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Insurance 1828.370 Fixed-price contract... Risk, in all negotiated fixed-price contracts for the development, production,...

  13. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.114 Fixed... that he will receive such fixed amount as straight time pay for whatever hours he is called upon...

  14. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Stations at temporary fixed locations. 101.815... SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at temporary fixed locations. (a) Authorizations may be issued upon proper application for the use of...

  15. 30 CFR 57.11026 - Protection for inclined fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Protection for inclined fixed ladders. 57.11026 Section 57.11026 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... and Escapeways Travelways-Surface Only § 57.11026 Protection for inclined fixed ladders. Fixed...

  16. 48 CFR 46.302 - Fixed-price supply contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price supply... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.302 Fixed-price supply contracts. The contracting officer shall insert the clause at 52.246-2, Inspection of Supplies—Fixed-Price, in solicitations...

  17. 48 CFR 46.302 - Fixed-price supply contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price supply... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.302 Fixed-price supply contracts. The contracting officer shall insert the clause at 52.246-2, Inspection of Supplies—Fixed-Price, in solicitations...

  18. 48 CFR 1828.370 - Fixed-price contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Fixed-price contract... ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Insurance 1828.370 Fixed-price contract... Risk, in all negotiated fixed-price contracts for the development, production,...

  19. 46 CFR 153.1502 - Fixed ballast relocation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Fixed ballast relocation. 153.1502 Section 153.1502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS....1502 Fixed ballast relocation. No person may remove or relocate fixed ballast unless: (a) The change...

  20. 46 CFR 153.1502 - Fixed ballast relocation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Fixed ballast relocation. 153.1502 Section 153.1502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS....1502 Fixed ballast relocation. No person may remove or relocate fixed ballast unless: (a) The change...

  1. 47 CFR 101.815 - Stations at temporary fixed locations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Stations at temporary fixed locations. 101.815... SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.815 Stations at temporary fixed locations. (a) Authorizations may be issued upon proper application for the use of...

  2. 30 CFR 56.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Inclined fixed ladders. 56.11017 Section 56.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11017 Inclined fixed ladders. Fixed ladders shall not incline backwards....

  3. 29 CFR 1910.162 - Fixed extinguishing systems, gaseous agent.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Fixed extinguishing systems, gaseous agent. 1910.162... ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Fixed Fire Suppression Equipment § 1910.162 Fixed extinguishing systems, gaseous agent. (a) Scope and...

  4. 30 CFR 57.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Fixed ladder landings. 57.11006 Section 57.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11006 Fixed ladder landings. Fixed ladders shall...

  5. 30 CFR 57.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Fixed ladder landings. 57.11006 Section 57.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11006 Fixed ladder landings. Fixed ladders shall...

  6. 29 CFR 1910.24 - Fixed industrial stairs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Fixed industrial stairs. 1910.24 Section 1910.24 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.24 Fixed industrial stairs. (a... fixed general industrial stairs. This classification includes interior and exterior stairs...

  7. 48 CFR 1816.202 - Firm-fixed-price contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Firm-fixed-price contracts... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202 Firm-fixed-price contracts....

  8. 30 CFR 75.360 - Preshift examination at fixed intervals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Preshift examination at fixed intervals. 75.360... examination at fixed intervals. (a)(1) Except as provided in paragraph (a)(2) of this section, a certified... added and revised text is set forth as follows: § 75.360 Preshift examination at fixed intervals....

  9. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  10. 48 CFR 52.216-8 - Fixed Fee.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Fixed Fee. 52.216-8... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.216-8 Fixed... cost-plus-fixed-fee contract (other than a facilities contract or a construction contract)...

  11. 46 CFR 193.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fixed fire extinguishing systems. 193.05-10 Section 193... Fixed fire extinguishing systems. (a) Approved fire extinguishing systems shall be installed in those locations delineated in this section. (b) A fixed carbon dioxide or other approved system shall be...

  12. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fixed extinguishing system, general. 169.564 Section 169... VESSELS Lifesaving and Firefighting Equipment Firefighting Equipment § 169.564 Fixed extinguishing system, general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed...

  13. 48 CFR 31.102 - Fixed-price contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Fixed-price contracts. 31... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Applicability 31.102 Fixed-price contracts. The applicable subparts of part 31 shall be used in the pricing of fixed-price contracts,...

  14. 47 CFR 80.387 - Frequencies for Alaska fixed stations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Frequencies for Alaska fixed stations. 80.387... SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Alaska Fixed Stations § 80.387 Frequencies for Alaska fixed stations. (a) The carrier frequencies listed in (b) of this section are assignable for...

  15. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Temporary fixed stations. 22.1031 Section 22... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  16. 47 CFR 80.381 - Frequencies for operational fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequencies for operational fixed stations. 80... RADIO SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Operational Fixed Stations § 80.381 Frequencies for operational fixed stations. The following carrier frequencies in the 72-76 MHz band...

  17. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Temporary fixed stations. 22.1031 Section 22... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  18. 48 CFR 46.304 - Fixed-price service contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Fixed-price service... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.304 Fixed-price service contracts. The contracting officer shall insert the clause at 52.246-4, Inspection of Services—Fixed-Price, in...

  19. 47 CFR 22.737 - Temporary fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Temporary fixed stations. 22.737 Section 22.737... Radiotelephone Service Conventional Rural Radiotelephone Stations § 22.737 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed...

  20. 47 CFR 80.387 - Frequencies for Alaska fixed stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Frequencies for Alaska fixed stations. 80.387... SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Alaska Fixed Stations § 80.387 Frequencies for Alaska fixed stations. (a) The carrier frequencies listed in (b) of this section are assignable for...

  1. 48 CFR 46.304 - Fixed-price service contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Fixed-price service... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.304 Fixed-price service contracts. The contracting officer shall insert the clause at 52.246-4, Inspection of Services—Fixed-Price, in...

  2. 47 CFR 22.1031 - Temporary fixed stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Temporary fixed stations. 22.1031 Section 22... MOBILE SERVICES Offshore Radiotelephone Service § 22.1031 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed stations in...

  3. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.114 Fixed... that he will receive such fixed amount as straight time pay for whatever hours he is called upon...

  4. 47 CFR 22.737 - Temporary fixed stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Temporary fixed stations. 22.737 Section 22.737... Radiotelephone Service Conventional Rural Radiotelephone Stations § 22.737 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed...

  5. 47 CFR 80.387 - Frequencies for Alaska fixed stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequencies for Alaska fixed stations. 80.387... SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Alaska Fixed Stations § 80.387 Frequencies for Alaska fixed stations. (a) The carrier frequencies listed in (b) of this section are assignable for...

  6. 30 CFR 57.11017 - Inclined fixed ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Inclined fixed ladders. 57.11017 Section 57.11017 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11017 Inclined fixed ladders. Fixed ladders shall...

  7. 47 CFR 22.737 - Temporary fixed stations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Temporary fixed stations. 22.737 Section 22.737... Radiotelephone Service Conventional Rural Radiotelephone Stations § 22.737 Temporary fixed stations. The FCC may, upon proper application therefor, authorize the construction and operation of temporary fixed...

  8. 46 CFR 193.05-10 - Fixed fire extinguishing systems.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Fixed fire extinguishing systems. 193.05-10 Section 193... Fixed fire extinguishing systems. (a) Approved fire extinguishing systems shall be installed in those locations delineated in this section. (b) A fixed carbon dioxide or other approved system shall be...

  9. 48 CFR 31.102 - Fixed-price contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Fixed-price contracts. 31... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Applicability 31.102 Fixed-price contracts. The applicable subparts of part 31 shall be used in the pricing of fixed-price contracts,...

  10. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  11. 48 CFR 1816.202 - Firm-fixed-price contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Firm-fixed-price contracts... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202 Firm-fixed-price contracts....

  12. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.114 Fixed... that he will receive such fixed amount as straight time pay for whatever hours he is called upon...

  13. 30 CFR 56.11006 - Fixed ladder landings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Fixed ladder landings. 56.11006 Section 56.11006 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11006 Fixed ladder landings. Fixed ladders shall project at least 3 feet above landings, or...

  14. 47 CFR 80.387 - Frequencies for Alaska fixed stations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Frequencies for Alaska fixed stations. 80.387... SERVICES STATIONS IN THE MARITIME SERVICES Frequencies Alaska Fixed Stations § 80.387 Frequencies for Alaska fixed stations. (a) The carrier frequencies listed in (b) of this section are assignable for...

  15. 47 CFR 90.245 - Fixed relay stations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Fixed relay stations. 90.245 Section 90.245... MOBILE RADIO SERVICES Non-Voice and Other Specialized Operations § 90.245 Fixed relay stations. Except where specifically provided for, fixed relay stations shall be authorized to operate only on...

  16. 48 CFR 52.216-8 - Fixed Fee.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Fixed Fee. 52.216-8... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.216-8 Fixed... cost-plus-fixed-fee contract (other than a facilities contract or a construction contract)...

  17. 46 CFR 28.320 - Fixed gas fire extinguishing systems.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Fixed gas fire extinguishing systems. 28.320 Section 28..., 1991, and That Operate With More Than 16 Individuals on Board § 28.320 Fixed gas fire extinguishing...) or more in length must be fitted with a fixed gas fire extinguishing system in the following...

  18. 48 CFR 46.302 - Fixed-price supply contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Fixed-price supply... CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.302 Fixed-price supply contracts. The contracting officer shall insert the clause at 52.246-2, Inspection of Supplies—Fixed-Price, in solicitations...

  19. 48 CFR 1816.202 - Firm-fixed-price contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Firm-fixed-price contracts... ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 1816.202 Firm-fixed-price contracts....

  20. 46 CFR 108.631 - Fixed fire extinguishing system controls.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Fixed fire extinguishing system controls. 108.631... DRILLING UNITS DESIGN AND EQUIPMENT Equipment Markings and Instructions § 108.631 Fixed fire extinguishing system controls. (a) Each cabinet or space that contains a valve, control, or manifold of a fixed...

  1. 48 CFR 47.104-2 - Fixed-price contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price contracts. 47... MANAGEMENT TRANSPORTATION General 47.104-2 Fixed-price contracts. (a) F.o.b. destination. 49 U.S.C. 10721 and 13712 rates do not apply to shipments under fixed-price f.o.b. destination contracts (delivered...

  2. 29 CFR 778.114 - Fixed salary for fluctuating hours.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Fixed salary for fluctuating hours. 778.114 Section 778.114... Overtime Pay Requirements Principles for Computing Overtime Pay Based on the âregular Rateâ § 778.114 Fixed... that he will receive such fixed amount as straight time pay for whatever hours he is called upon...

  3. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Fixed and portable ladders. 1918.24 Section 1918.24 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Gangways and Other Means of Access § 1918.24 Fixed... each vertical fixed ladder. No more than two ladders are required in any hatch regardless of the...

  4. 49 CFR 218.109 - Hand-operated fixed derails.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Hand-operated fixed derails. 218.109 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Handling Equipment, Switches, and Fixed Derails § 218.109 Hand-operated fixed derails. (a)(1) Each railroad shall adopt and comply with...

  5. 48 CFR 47.104-2 - Fixed-price contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price contracts. 47... MANAGEMENT TRANSPORTATION General 47.104-2 Fixed-price contracts. (a) F.o.b. destination. 49 U.S.C. 10721 and 13712 rates do not apply to shipments under fixed-price f.o.b. destination contracts (delivered...

  6. 48 CFR 1828.370 - Fixed-price contract clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Fixed-price contract... ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Insurance 1828.370 Fixed-price contract... Risk, in all negotiated fixed-price contracts for the development, production,...

  7. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fixed extinguishing system, general. 169.564 Section 169... VESSELS Lifesaving and Firefighting Equipment Firefighting Equipment § 169.564 Fixed extinguishing system, general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed...

  8. 48 CFR 1828.370 - Fixed-price contract clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Fixed-price contract... ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Insurance 1828.370 Fixed-price contract... Risk, in all negotiated fixed-price contracts for the development, production,...

  9. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Fixed extinguishing system, general. 169.564 Section 169... VESSELS Lifesaving and Firefighting Equipment Firefighting Equipment § 169.564 Fixed extinguishing system, general. (a) Fixed carbon dioxide or halogenated extinguishing systems must be installed to protect...

  10. 29 CFR 1910.162 - Fixed extinguishing systems, gaseous agent.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Fixed extinguishing systems, gaseous agent. 1910.162... ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS Fire Protection Fixed Fire Suppression Equipment § 1910.162 Fixed extinguishing systems, gaseous agent. (a) Scope and...

  11. 29 CFR 1910.24 - Fixed industrial stairs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Fixed industrial stairs. 1910.24 Section 1910.24 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Walking-Working Surfaces § 1910.24 Fixed industrial stairs. (a... fixed general industrial stairs. This classification includes interior and exterior stairs...

  12. 46 CFR 169.564 - Fixed extinguishing system, general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fixed extinguishing system, general. 169.564 Section 169... VESSELS Lifesaving and Firefighting Equipment Firefighting Equipment § 169.564 Fixed extinguishing system, general. (a) A fixed carbon dioxide, Halon 1301, or clean agent extinguishing system must be installed...

  13. 40 CFR 63.1042 - Standards-Separator fixed roof.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Standards-Separator fixed roof. 63...—Separator fixed roof. (a) This section applies to owners and operators subject to this subpart and controlling air emissions from an oil-water separator or organic-water separator using a fixed roof. (b)...

  14. 46 CFR 153.1502 - Fixed ballast relocation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Fixed ballast relocation. 153.1502 Section 153.1502 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS....1502 Fixed ballast relocation. No person may remove or relocate fixed ballast unless: (a) The change...

  15. 48 CFR 47.104-2 - Fixed-price contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Fixed-price contracts. 47... MANAGEMENT TRANSPORTATION General 47.104-2 Fixed-price contracts. (a) F.o.b. destination. 49 U.S.C. 10721 and 13712 rates do not apply to shipments under fixed-price f.o.b. destination contracts (delivered...

  16. 48 CFR 31.102 - Fixed-price contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Fixed-price contracts. 31... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Applicability 31.102 Fixed-price contracts. The applicable subparts of part 31 shall be used in the pricing of fixed-price contracts,...

  17. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Fixed and portable ladders. 1918.24 Section 1918.24 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Gangways and Other Means of Access § 1918.24 Fixed... each vertical fixed ladder. No more than two ladders are required in any hatch regardless of the...

  18. 12 CFR 701.36 - FCU ownership of fixed assets.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false FCU ownership of fixed assets. 701.36 Section... ORGANIZATION AND OPERATION OF FEDERAL CREDIT UNIONS § 701.36 FCU ownership of fixed assets. (a) Investment in Fixed Assets. (1) No Federal credit union with $1,000,000 or more in assets may invest in any...

  19. 48 CFR 52.216-8 - Fixed Fee.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Fixed Fee. 52.216-8... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.216-8 Fixed... cost-plus-fixed-fee contract (other than a facilities contract or a construction contract)...

  20. 29 CFR 1918.24 - Fixed and portable ladders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Fixed and portable ladders. 1918.24 Section 1918.24 Labor... (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Gangways and Other Means of Access § 1918.24 Fixed... each vertical fixed ladder. No more than two ladders are required in any hatch regardless of the...