Science.gov

Sample records for 1s core level

  1. Exploring large O 1s and N 1s core level shifts due to intermolecular hydrogen bond formation in organic molecules

    NASA Astrophysics Data System (ADS)

    Garcia-Gil, S.; Arnau, A.; Garcia-Lekue, A.

    2013-07-01

    Core level shifts (CLSs) induced by intermolecular hydrogen bond (H-bond) formation are studied with a recent implementation based on density functional theory using pseudopotentials and localized atomic orbitals, as applied to the SIESTA code. By calculating different CLSs for a set of representative simple systems containing O and/or N atoms as proton donors and/or acceptors, we are able to determine the role of the core hole screening, from the difference of CLS values calculated in the final and initial state approximations. Our calculations show that CLSs are dominated by electrostatic effects, and that the final magnitude of the CLSs, which are positive (higher binding energy) for the proton acceptor and negative for the proton donor, can be larger than 1 eV for strong H-bonds. We also find that core hole screening contribution to final CLS absolute values is always negative, thus being responsible for the difference in the magnitude of the CLS of the proton donor and proton acceptor.

  2. sp2/sp3 hybridization ratio in amorphous carbon from C 1s core-level shifts: X-ray photoelectron spectroscopy and first-principles calculation

    NASA Astrophysics Data System (ADS)

    Haerle, Rainer; Riedo, Elisa; Pasquarello, Alfredo; Baldereschi, Alfonso

    2002-01-01

    Using a combined experimental and theoretical approach, we address C 1s core-level shifts in amorphous carbon. Experimental results are obtained by x-ray photoelectron spectroscopy (XPS) and electron-energy-loss spectroscopy (EELS) on thin-film samples of different atomic density, obtained by a pulsed-laser deposition growth process. The XPS spectra are deconvoluted into two contributions, which are attributed to sp2- and sp3-hybridized atoms, respectively, separated by 0.9 eV, independent of atomic density. The sp3 hybridization content extracted from XPS is consistent with the atomic density derived from the plasmon energy in the EELS spectrum. In our theoretical study, we generate several periodic model structures of amorphous carbon of different densities applying two schemes of increasing accuracy in sequence. We first use a molecular-dynamics approach, based on an environmental-dependent tight-binding Hamiltonian to quench the systems from the liquid phase. The final model structures are then obtained by further atomic relaxation using a first-principles pseudopotential plane-wave approach within density-functional theory. Within the latter framework, we also calculate carbon 1s core-level shifts for our disordered model structures. We find that the shifts associated to threefold- and fourfold- coordinated carbon atoms give rise to two distinct peaks separated by about 1.0 eV, independent of density, in close agreement with experimental observations. This provides strong support for decomposing the XPS spectra into two peaks resulting from sp2- and sp3-hybridized atoms. Core-hole relaxations effects account for about 30% of the calculated shifts.

  3. Core level shifts of intercalated graphene

    NASA Astrophysics Data System (ADS)

    Schröder, Ulrike A.; Petrović, Marin; Gerber, Timm; Martínez-Galera, Antonio J.; Grånäs, Elin; Arman, Mohammad A.; Herbig, Charlotte; Schnadt, Joachim; Kralj, Marko; Knudsen, Jan; Michely, Thomas

    2017-03-01

    Through intercalation of metals and gases the Dirac cone of graphene on Ir(111) can be shifted with respect to the Fermi level without becoming destroyed by strong hybridization. Here, we use x-ray photoelectron spectroscopy to measure the C 1s core level shift (CLS) of graphene in contact with a number of structurally well-defined intercalation layers (O, H, Eu, and Cs). By analysis of our own and additional literature data for decoupled graphene, the C 1s CLS is found to be a non-monotonic function of the doping level. For small doping levels the shifts are well described by a rigid band model. However, at larger doping levels, a second effect comes into play which is proportional to the transferred charge and counteracts the rigid band shift. Moreover, not only the position, but also the C 1s peak shape displays a unique evolution as a function of doping level. Our conclusions are supported by intercalation experiments with Li, with which, due to the absence of phase separation, the doping level of graphene can be continuously tuned.

  4. Trends in adsorbate induced core level shifts

    NASA Astrophysics Data System (ADS)

    Nilsson, Viktor; Van den Bossche, Maxime; Hellman, Anders; Grönbeck, Henrik

    2015-10-01

    Photoelectron core level spectroscopy is commonly used to monitor atomic and molecular adsorption on metal surfaces. As changes in the electron binding energies are convoluted measures with different origins, calculations are often used to facilitate the decoding of experimental signatures. The interpretation could in this sense benefit from knowledge on trends in surface core level shifts for different metals and adsorbates. Here, density functional theory calculations have been used to systematically evaluate core level shifts for (111) and (100) surfaces of 3d, 4d, and 5d transition metals upon CO, H, O and S adsorption. The results reveal trends and several non-intuitive cases. Moreover, the difficulties correlating core level shifts with charging and d-band shifts are underlined.

  5. Final-state symmetry of Na 1s core-shell excitons in NaCl and NaF

    SciTech Connect

    Nagle, K.P.; Seidler, G.T.; Shirley, E.L.; Fister, T.T.; Bradley, J.A.; Brown, F.C.

    2009-08-13

    We report measurements of the Na 1s contribution to the nonresonant inelastic x-ray scattering (NRIXS) from NaCl and NaF. Prior x-ray absorption studies have observed two pre-edge excitons in both materials. The momentum-transfer dependence (q dependence) of the measured NRIXS cross section and of real-space full multiple scattering and Bethe-Salpeter calculations determine that the higher-energy core excitons are s type for each material. The lower-energy core excitons contribute at most weakly to the NRIXS signal and we propose that these may be surface core excitons, as have been observed in several other alkali halides. The analysis of the orbital angular momentum of these features leads to a discussion of the limited sensitivity of NRIXS measurements to d-type final states when investigating 1s initial states. In this case the s- and p-type final density of states can be characterized by measurements at a small number of momentum transfers. This is in contrast to the case of more complex initial states for which measurements at a large number of momentum transfers are needed to separate the rich admixture of accessible and contributing final-state symmetries.

  6. The surface core level shift for lithium at the surface of lithium borate

    NASA Astrophysics Data System (ADS)

    Wooten, David; Ketsman, I.; Xiao, Jie; Losovyj, Ya. B.; Petrosky, J.; McClory, J.; Burak, Ya. V.; Adamiv, V. T.; Dowben, P. A.

    2010-01-01

    The shallow Li 1s core level exhibits a surface-to-bulk core level shift for the stoichiometric Li 2B 4O 7(1 1 0) surface. Angle-resolved photoemission spectroscopy was used to indentify Li 1s bulk and surface core level components at binding energies -56.5±0.4 and -53.7±0.5 eV, respectively. We find photoemission evidence for surface states of Li 2B 4O 7(1 1 0) that exist in the gap of the projected bulk density of states. The existence of surface states is consistent with the large surface-to-bulk core level shift for the Li 1s core.

  7. Rotational level involvement in the T1-->S0 intersystem crossing transition in thiophosgene.

    PubMed

    Rashev, Svetoslav; Moule, David C

    2009-04-07

    We propose and develop theoretically a general mechanism for the involvement of rotational motion into the nonradiative transitions that occur in an isolated polyatomic molecule. The treatment is based on the different rotational constants and different (asymmetric top-symmetric top) molecular structures in the two combining electronic states. We focus our attention on the T(1)-->S(0) intersystem crossing (ISC) transition in thiophosgene and show how the rotational mechanism could lead to a considerable enhancement in the effective level density for the process. Inserting the rotational mechanism into our recently developed technique and algorithm for combined spin-orbit coupling+intramolecular vibrational redistribution analysis, we have carried out large-scale calculations that have led to a better understanding of the ISC (T(1)-->S(0)) in thiophosgene.

  8. Levels of plasma soluble complement receptor 1 (sCR1) in normal Indian adult population.

    PubMed

    Sivasankar, B; Raju, K R; Anand, V; Malu, S; Padmanabhan, S; Tiwari, S C; Das, N; Srivastava, L M

    1999-07-01

    A decrease in the membrane anchored erythrocyte complement receptor 1 (CR1) is reported as an acquired phenomenon in a number of inflammatory and autoimmune diseases with concomitant rise in soluble CR1 (sCR1) levels in plasma. There is a need to establish the normal range of sCR1 in Indian adults to assess the function and disease association of this protein. The plasma sCR1 levels of 50 healthy individuals have been estimated by an indigenously developed sandwich ELISA. sCR1 levels from 26 patients suffering from nephropathies had also been assayed which was much higher than the normal controls. This observation suggests sCR1 as a potential market for the assessment of disease activity in nephropathies.

  9. Quantum mechanics/molecular mechanics modeling of photoelectron spectra: the carbon 1s core-electron binding energies of ethanol-water solutions.

    PubMed

    Löytynoja, T; Niskanen, J; Jänkälä, K; Vahtras, O; Rinkevicius, Z; Ågren, H

    2014-11-20

    Using ethanol-water solutions as illustration, we demonstrate the capability of the hybrid quantum mechanics/molecular mechanics (QM/MM) paradigm to simulate core photoelectron spectroscopy: the binding energies and the chemical shifts. An integrated approach with QM/MM binding energy calculations coupled to preceding molecular dynamics sampling is adopted to generate binding energies averaged over the solute-solvent configurations available at a particular temperature and pressure and thus allowing for a statistical assessment with confidence levels for the final binding energies. The results are analyzed in terms of the contributions in the molecular mechanics model-electrostatic, polarization, and van der Waals-with atom or bond granulation of the corresponding MM charge and polarizability force-fields. The role of extramolecular charge transfer screening of the core-hole and explicit hydrogen bonding is studied by extending the QM core to cover the first solvation shell. The results are compared to those obtained from pure electrostatic and polarizable continuum models. Particularly, the dependence of the carbon 1s binding energies with respect to the ethanol concentration is studied. Our results indicate that QM/MM can be used as an all-encompassing model to study photoelectron binding energies and chemical shifts in solvent environments.

  10. Autophagy Defects Suggested by Low Levels of Autophagy Activator MAP1S and High Levels of Autophagy Inhibitor LRPPRC Predict Poor Prognosis of Prostate Cancer Patients

    PubMed Central

    Jiang, Xianhan; Zhong, Weide; Huang, Hai; He, Huichan; Jiang, Funeng; Chen, Yanru; Yue, Fei; Zou, Jing; Li, Xun; He, Yongzhong; You, Pan; Yang, Weiqiang; Lai, Yiming; Wang, Fen; Liu, Leyuan

    2016-01-01

    MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. Mitochondrion-associated protein LRPPRC functions as an inhibitor for autophagy initiation to protect mitochondria from autophagy degradation. MAP1S and LRPPRC interact with each other and may collaboratively regulate autophagy although the underlying mechanism is yet unknown. Previously, we have reported that LRPPRC levels serve as a prognosis marker of patients with prostate adenocarcinomas (PCA), and that patients with high LRPPRC levels survive a shorter period after surgery than those with low levels of LRPPRC. MAP1S levels are elevated in diethylnitrosamine-induced hepatocelular carcinomas in wildtype mice and the exposed MAP1S-deficient mice develop more malignant hepatocellular carcinomas. We performed immunochemical analysis to evaluate the co-relationship among the levels of MAP1S, LRPPRC, P62, and γ-H2AX. Samples were collected from wildtype and prostate-specific PTEN-deficient mice, 111 patients with PCA who had been followed up for 10 years and 38 patients with benign prostate hyperplasia enrolled in hospitals in Guangzhou, China. The levels of MAP1S were generally elevated so the MAP1S-mediated autophagy was activated in PCA developed in either PTEN-deficient mice or patients than their respective benign tumors. The MAP1S levels among patients with PCA vary dramatically, and patients with low MAP1S levels survive a shorter period than those with high MAP1S levels. Levels of MAP1S in collaboration with levels of LRPPRC can serve as markers for prognosis of prostate cancer patients. PMID:25043940

  11. Positive and negative ion formation in deep-core excited molecules: S 1s excitation in dimethyl sulfoxide

    SciTech Connect

    Coutinho, L. H.; Gardenghi, D. J.; Schlachter, A. S.; Souza, G. G. B. de; Stolte, W. C.

    2014-01-14

    The photo-fragmentation of the dimethyl sulfoxide (DMSO) molecule was studied using synchrotron radiation and a magnetic mass spectrometer. The total cationic yield spectrum was recorded in the photon energy region around the sulfur K edge. The sulfur composition of the highest occupied molecular orbital's and lowest unoccupied molecular orbital's in the DMSO molecule has been obtained using both ab initio and density functional theory methods. Partial cation and anion-yield measurements were obtained in the same energy range. An intense resonance is observed at 2475.4 eV. Sulfur atomic ions present a richer structure around this resonant feature, as compared to other fragment ions. The yield curves are similar for most of the other ionic species, which we interpret as due to cascade Auger processes leading to multiply charged species which then undergo Coulomb explosion. The anions S{sup −}, C{sup −}, and O{sup −} are observed for the first time in deep-core-level excitation of DMSO.

  12. Laser techniques for spectroscopy of core-excited atomic levels

    NASA Technical Reports Server (NTRS)

    Harris, S. E.; Young, J. F.; Falcone, R. W.; Rothenberg, J. E.; Willison, J. R.

    1982-01-01

    We discuss three techniques which allow the use of tunable lasers for high resolution and picosecond time scale spectroscopy of core-excited atomic levels. These are: anti-Stokes absorption spectroscopy, laser induced emission from metastable levels, and laser designation of selected core-excited levels.

  13. Core-level excitation and fragmentation of chlorine dioxide

    NASA Astrophysics Data System (ADS)

    Flesch, R.; Plenge, J.; Rühl, E.

    2006-03-01

    Inner-shell excitation and fragmentation of chlorine dioxide (OClO) in the Cl 2p- and O 1s-excitation regime is reported. The electronic structure of the element-selectively excited radical is studied by X-ray absorption and total cation yields. A comparison of both approaches allows us to estimate the absolute photoionization cross-section and the ionization yield near the Cl 2p- and O 1s-absorption edges. The latter quantity is characteristically enhanced in core-ionization continua. We observe below both core-absorption edges intense core-to-valence-transitions. These are assigned in comparison with related work on core-excited sulfur dioxide. These results give clear evidence that the highest molecular orbital of OClO is half-filled. High-resolution spectra recorded in the Cl 2p-regime show evidence for Rydberg transitions. The extrapolation of the term values of the low-lying Rydberg states allows us to derive the Cl 2p-ionization energy of OClO. Fragmentation of core-excited OClO is reported. Photoelectron-photoion-coincidence (PEPICO) spectra are recorded, indicating that singly and doubly charged fragments are formed. Fission of the doubly and multiply charged OClO leads to singly charged fragments. These are measured by photoion-photoion-coincidence (PIPICO) spectra, where characteristic changes in intensity of the fission channels in the Cl 2p- and O 1s-continuum are observed.

  14. Electron-impact core excitation of SF6. I. S 2p, S 2s, and F 1s spectroscopy

    NASA Astrophysics Data System (ADS)

    Francis, James T.; Turci, Cássia C.; Tyliszczak, Tolek; de Souza, G. Gerson B.; Kosugi, Nobuhiro; Hitchcock, Adam P.

    1995-12-01

    Electron energy-loss spectra (EELS) of SF6 have been recorded in the region of S 2p, S 2s, and F 1s excitation, using both dipole and nondipole electron-scattering conditions. Impact energies between 700 and 3200 eV and scattering angles between 0° and 30° were used. Relative to dipole EELS or photoabsorption, there are large intensity redistributions in both the S 2p and S 2s spectra under nondipole conditions. In contrast, the F 1s spectrum is essentially the same in near-dipole and nondipole scattering regimes. A higher-order electric multiple S 2p spectra feature is observed at 181 eV. It has an unusual multipeaked line shape whose components are more closely spaced than the typical 1.15-eV S 2p spin-orbit splitting. It is attributed to the overlap of several quadrupole-coupled states, which are likely associated with the [S 2p(t1u)-1,t1u] configuration. Ab initio self-consistent field calculations for various open-shell S 2p excited states are used to assist spectral assignments.

  15. Probing core-electron orbitals by scanning transmission electron microscopy and measuring the delocalization of core-level excitations

    NASA Astrophysics Data System (ADS)

    Jeong, Jong Seok; Odlyzko, Michael L.; Xu, Peng; Jalan, Bharat; Mkhoyan, K. Andre

    2016-04-01

    By recording low-noise energy-dispersive x-ray spectroscopy maps from crystalline specimens using aberration-corrected scanning transmission electron microscopy, it is possible to probe core-level electron orbitals in real space. Both the 1 s and 2 p orbitals of Sr and Ti atoms in SrTi O3 are probed, and their projected excitation potentials are determined. This paper also demonstrates experimental measurement of the electronic excitation impact parameter and the delocalization of an excitation due to Coulombic beam-orbital interaction.

  16. 1s22pns(1P0) autoionizing levels in Be-like Al and C ions

    NASA Astrophysics Data System (ADS)

    Stancalie, V.

    2005-04-01

    This work is focused on the possibility of using the R-matrix Floquet theory and codes and its extension to laser induced degenerate state to describe dielectronic recombination of Li-like into Be-like ions. The uncertainty concerning the best way to include radiative damping effect is no longer a problem when the full electron collision and radiative processes are treated simultaneously and radiation field is treated to all orders. The method accounts for the reverse process corresponding to single-photon ionization. Following this approach, the 1s22snl(Se1) and 1s22pnl(P01) Rydberg states, embedded in the electric dipole field of the 2s-2p core, are dressed by a laser field, assumed to be monochromatic, monomode, linearly polarized, and spatially homogeneous. As in the R-matrix Floquet theory, in the external region, since the coupling field potential vanishes, the calculation yields the complete information on the autoionizing rate and field-free positions. Comparisons with available data are presented.

  17. Level set-based core segmentation of mammographic masses facilitating three stage (core, periphery, spiculation) analysis.

    PubMed

    Ball, John E; Bruce, Lori Mann

    2007-01-01

    We present mammographic mass core segmentation, based on the Chan-Vese level set method. The proposed method is analyzed via resulting feature efficacies. Additionally, the core segmentation method is used to investigate the idea of a three stage segmentation approach, i.e. segment the mass core, periphery, and spiculations (if any exist) and use features from these three segmentations to classify the mass as either benign or malignant. The proposed core segmentation method and a proposed end-to-end computer aided detection (CAD) system using a three stage segmentation are implemented and experimentally tested with a set of 60 mammographic images from the Digital Database of Screening Mammography. Receiver operating characteristic (ROC) curve AZ values for morphological and texture features extracted from the core segmentation are shown to be on par, or better, than those extracted from a periphery segmentation. The efficacy of the core segmentation features when combined with the periphery and spiculation segmentation features are shown to be feature set dependent. The proposed end-to-end system uses stepwise linear discriminant analysis for feature selection and a maximum likelihood classifier. Using all three stages (core + periphery + spiculations) results in an overall accuracy (OA) of 90% with 2 false negatives (FN). Since many CAD systems only perform a periphery analysis, adding core features could be a benefit to potentially increase OA and reduce FN cases.

  18. Idaho Marketing Education Core Curriculum. Career Sustaining Level, Specialist Level, Supervisory Level, Entrepreneurial Level.

    ERIC Educational Resources Information Center

    Miller, Linda Wise; Winn, Richard

    This document contains Idaho's marketing education (ME) core curriculum. Presented first are a list of 22 ME strategies that are aligned with the Idaho State Division of Vocational-Technical Education's strategic plan and a chart detailing the career pathways of ME in Idaho (arts and communication, business and management, health services, human…

  19. Core-level photoabsorption characterization of diamond and carbon films

    SciTech Connect

    Terminello, L.J.; Carlisle, J.A.; Sutherland, D.G.

    1996-12-31

    We have used synchrotron radiation core-level photoabsorption to characterize the electronic structure and morphology of carbon thin-films and determined the relative ratio of sp2 vs. sp3 bonding. The diamond, diamond-like, and carbon films characterized were prepared by a variety of methods including sputtering, CVD, microwave plasma CVD, and laser ablation. We have also measured these films using Raman spectroscopy and have found that in cases where the domain size of the crystallites in the carbon films was nanoscopic (less than 100 nm), Raman spectroscopy gave indeterminate results. In these cases, as well as with larger crystallite size films, core-level photoabsorption was able to unambiguously identify the bonding in the film. We will present photoabsorption data obtained from these materials. These experiments and prospects for other experiments that can identify the unique electronic properties and bonding of such novel thin films will be discussed.

  20. Gamma thermometer based reactor core liquid level detector

    DOEpatents

    Burns, Thomas J.

    1983-01-01

    A system is provided which employs a modified gamma thermometer for determining the liquid coolant level within a nuclear reactor core. The gamma thermometer which normally is employed to monitor local core heat generation rate (reactor power), is modified by thermocouple junctions and leads to obtain an unambiguous indication of the presence or absence of coolant liquid at the gamma thermometer location. A signal processor generates a signal based on the thermometer surface heat transfer coefficient by comparing the signals from the thermocouples at the thermometer location. The generated signal is a direct indication of loss of coolant due to the change in surface heat transfer when coolant liquid drops below the thermometer location. The loss of coolant indication is independent of reactor power at the thermometer location. Further, the same thermometer may still be used for the normal power monitoring function.

  1. Gamma thermometer based reactor core liquid level detector

    SciTech Connect

    Burns, T.J.

    1983-09-20

    A system is provided which employs a modified gamma thermometer for determining the liquid coolant level within a nuclear reactor core. The gamma thermometer which normally is employed to monitor local core heat generation rate (reactor power), is midified by thermocouple junctions and leads to obtain an unambiguous indication of the presence or absence of coolant liquid at the gamma thermometer location. A signal processor generates a signal based on the thermometer surface heat transfer coefficient by comparing the signals from the thermocouples at the thermometer location. The generated signal is a direct indication of loss of coolant due to the change in surface heat transfer when coolant liquid drops below the thermometer location. The loss of coolant indication is independent of reactor power at the thermometer location. Further, the same thermometer may still be used for the normal power monitoring function.

  2. Ordering of the 0 d5 /2 and 1 s1 /2 proton levels in light nuclei

    NASA Astrophysics Data System (ADS)

    Hoffman, C. R.; Kay, B. P.; Schiffer, J. P.

    2016-08-01

    A survey of the available single-proton data in A ≤17 nuclei was completed. These data, along with calculations using a Woods-Saxon potential, show that the ordering of the 0 d5 /2 and 1 s1 /2 proton orbitals are determined primarily by the proximity of the s -state proton energy to the Coulomb barrier. This is analogous to the dependence of the corresponding neutron orbitals in proximity to the neutron threshold, which was previously discussed.

  3. Effects of non-local exchange on core level shifts for gas-phase and adsorbed molecules

    NASA Astrophysics Data System (ADS)

    Van den Bossche, M.; Martin, N. M.; Gustafson, J.; Hakanoglu, C.; Weaver, J. F.; Lundgren, E.; Grönbeck, H.

    2014-07-01

    Density functional theory calculations are often used to interpret experimental shifts in core level binding energies. Calculations based on gradient-corrected (GC) exchange-correlation functionals are known to reproduce measured core level shifts (CLS) of isolated molecules and metal surfaces with reasonable accuracy. In the present study, we discuss a series of examples where the shifts calculated within a GC-functional significantly deviate from the experimental values, namely the CLS of C 1s in ethyl trifluoroacetate, Pd 3d in PdO and the O 1s shift for CO adsorbed on PdO(101). The deviations are traced to effects of the electronic self-interaction error with GC-functionals and substantially better agreements between calculated and measured CLS are obtained when a fraction of exact exchange is used in the exchange-correlation functional.

  4. Core-level binding-energy shifts for the metallic elements

    NASA Astrophysics Data System (ADS)

    Johansson, Börje; Mårtensson, Nils

    1980-05-01

    chromium relative to the dns2 configuration in vanadium and manganese. When the core-level shift is referred to, the dns2 (or dn+1s) atomic configuration for all the elements in a transition series, a quite regular behavior of the shift is found. However, some structure can still be observed originating from a change of screening within the d band from a bonding to an antibonding type as one proceeds through the series. For elements beyond the coin metals the screening of a core hole is performed by p electrons, which provide a less effective screening mechanism than the d electrons for the transition metals. The coin metals are intermediate cases, partly due to a dominating s-electron screening and partly due to d-electron bonding in the initial state. The effect of the electron-density redistribution between the free atom and the solid on the core-level shift is particularly striking in the case of the rare-earth elements Pr-Sm and Tb-Tm. Here the remarkable situation is that a deep core electron is less bound in the atom than in the solid. Also for the actinides the electronic redistribution upon condensation gives rise to pronounced effects on the core-level shifts. Further, it is shown that the measured 6p32 binding energy in metallic uranium provides a clear demonstration of the occupation of the 5f level in this metal. The present treatment of the core-level shift for bulk metallic atoms can easily be generalized to surface atoms. From an empirical relation for the surface energy a simple expression for the shift of the surface core-level relative to the bulk can be derived. For the earlier transition metals, it is found that the core electrons are more bound at the surface than in the bulk, while for the heavier ones the opposite situation exists. This change of sign of the surface shift depends on the bonding-antibonding division of the d band. To illustrate how the present approach can be applied to alloy systems, a treatment of core-level shifts for rare

  5. Visual Arts, Levels 7-12. Secondary Core Curriculum Standards.

    ERIC Educational Resources Information Center

    Utah State Office of Education, Salt Lake City.

    This Utah state curriculum guide calls for one 7-8th grade course (0.5 unit) of visual arts education to fulfill the visual arts Component requirement of the core curriculum. Up to three visual arts courses may be taken at the 9-12th grades as fulfillment of the 1.5 core art units required. Core options include courses in ceramics, jewelry,…

  6. 1s{sup 2}2pns({sup 1}P{sup 0}) autoionizing levels in Be-like Al and C ions

    SciTech Connect

    Stancalie, V.

    2005-04-15

    This work is focused on the possibility of using the R-matrix Floquet theory and codes and its extension to laser induced degenerate state to describe dielectronic recombination of Li-like into Be-like ions. The uncertainty concerning the best way to include radiative damping effect is no longer a problem when the full electron collision and radiative processes are treated simultaneously and radiation field is treated to all orders. The method accounts for the reverse process corresponding to single-photon ionization. Following this approach, the 1s{sup 2}2snl({sup 1}S{sup e}) and 1s{sup 2}2pnl({sup 1}P{sup 0}) Rydberg states, embedded in the electric dipole field of the 2s-2p core, are dressed by a laser field, assumed to be monochromatic, monomode, linearly polarized, and spatially homogeneous. As in the R-matrix Floquet theory, in the external region, since the coupling field potential vanishes, the calculation yields the complete information on the autoionizing rate and field-free positions. Comparisons with available data are presented.

  7. Evidence of the nature of core-level photoemission satellites using angle-resolved photoemission extended fine structure

    SciTech Connect

    Moler, E.J.; Kellar, S.A.; Huff, W.R.A.

    1997-04-01

    The authors present a unique method of experimentally determining the angular momentum and intrinsic/extrinsic origin of core-level photoemission satellites by examining the satellite diffraction pattern in the Angle Resolved Photoemission Extended Fine Structure (ARPEFS) mode. They show for the first time that satellite peaks not associated with chemically differentiated atomic species display an ARPEFS intensity oscillation. They present ARPEFS data for the carbon 1s from ({radical}3x{radical}3)R30 CO/Cu(111) and p2mg(2xl)CO/Ni(110), nitrogen 1s from c(2x2) N{sub 2}/Ni(100), cobalt 1s from p(1x1)Co/Cu(100), and nickel 3p from clean nickel (111). The satellite peaks and tails of the Doniach-Sunjic line shapes in all cases exhibit ARPEFS curves which indicate an angular momentum identical to the main peak and are of an intrinsic nature.

  8. Atomic signatures of local environment from core-level spectroscopy in β -Ga2O3

    NASA Astrophysics Data System (ADS)

    Cocchi, Caterina; Zschiesche, Hannes; Nabok, Dmitrii; Mogilatenko, Anna; Albrecht, Martin; Galazka, Zbigniew; Kirmse, Holm; Draxl, Claudia; Koch, Christoph T.

    2016-08-01

    We present a joint theoretical and experimental study on core-level excitations from the oxygen K edge of β -Ga2O3 . A detailed analysis of the electronic structure reveals the importance of O-Ga hybridization effects in the conduction region. The spectrum from O 1 s core electrons is dominated by excitonic effects, which overall redshift the absorption onset by 0.5 eV, and significantly redistribute the intensity to lower energies. Analysis of the spectra obtained within many-body perturbation theory reveals atomic fingerprints of the inequivalent O atoms. From the comparison of energy-loss near-edge fine-structure (ELNES) spectra computed with respect to different crystal planes, with measurements recorded under the corresponding diffraction conditions, we show how the spectral contributions of specific O atoms can be enhanced while quenching others. These results suggest ELNES, combined with ab initio many-body theory, as a very powerful technique to characterize complex systems, with sensitivity to individual atomic species and to their local environment.

  9. Predicting core level binding energies shifts: Suitability of the projector augmented wave approach as implemented in VASP.

    PubMed

    Pueyo Bellafont, Noèlia; Viñes, Francesc; Hieringer, Wolfgang; Illas, Francesc

    2017-03-30

    Here, we assess the accuracy of various approaches implemented in Vienna ab initio simulation package code to estimate core-level binding energy shifts (ΔBEs) using a projector augmented wave method to treat core electrons. The performance of the Perdew-Burke-Ernzerhof (PBE) and the Tao-Perdew-Staroverov-Scuseria (TPSS) exchange-correlation density functionals is examined on a dataset of 68 molecules containing B→F atoms in diverse chemical environments, accounting for 185 different 1s core level binding energy shifts, for which both experimental gas-phase X-ray photoemission (XPS) data and accurate all electron ΔBEs are available. Four procedures to calculate core-level shifts are investigated. Janak-Slater transition state approach yields mean absolute errors of 0.37 (0.21) eV at PBE (TPSS) level, similar to highly accurate all electron ΔSCF approaches using same functionals, and close to XPS experimental accuracy of 0.1 eV. The study supports the use of these procedures to assign ΔBEs of molecular moieties on material surfaces of interest in surface science, nanotechnology, and heterogeneous catalysis. © 2017 Wiley Periodicals, Inc.

  10. Science, Levels 7-12. Secondary Core Curriculum Standards.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City. Div. of Curriculum and Instruction.

    This document presents the core science curriculum standards which must be completed by all students as a requisite for graduation from Utah's secondary schools. Contained within are the elementary and secondary school program of studies and high school graduation requirements. Each course entry for grades 7-12 contains: course title, unit of…

  11. At the core. A system measures the level of employee commitment to its core values.

    PubMed

    Solbach, M T; Atchison, T A; Ryan, K E

    1990-12-01

    Corporate culture has been described as the shared values that drive employee satisfaction and enhance employee commitment to the organization. Therefore system leaders must know the strength of their corporate culture. Sisters of St. Francis Health Services, Inc. (SFHS), wanted to measure whether it had a strong corporate culture based on its stated values. Executives, managers, and physicians completed surveys that assessed employee job satisfaction, commitment to the organization, and perceived strength of the system's culture. The survey achieved a 68 percent response rate. SFHS learned that it had a strong culture based on tradition and that special and unique core corporate values define "systemness" throughout its different facilities. Although each facility serves significantly different functions, leaders throughout the system make everyday decisions using the same core corporate values.

  12. Alkaline Earth Core Level Photoemission Spectroscopy of High-Temperature Superconductors

    NASA Technical Reports Server (NTRS)

    Vasquez, R.

    1993-01-01

    This paper examines photoemission measurements of the alkaline Earth core levels of high-temperature superconductors and related materials, models that seek to explain the large negative shifts observed relative to the corresponding alkaline Earth metals, and the effect of lattice site disorder on the core level spectra and the presence or absence of intrinsic surface peaks.

  13. Soluble complement receptor type 1 (sCR1) in chronic liver diseases: serum levels at different stages of liver diseases.

    PubMed

    Di Bona, D; Montalto, G; Clemenza, L; Bascone, F; Accardo, P; Bellavia, D; Craxì, A; Brai, M

    1998-10-01

    Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might originate directly from release of leucocytes and other circulating cells. In previous studies, an increase in serum sCR1 level has been observed in liver cirrhosis and end-stage renal failure. High levels have also been found in patients with some haematologic malignancies. sCR1 serum levels were measured using a specific double sandwich ELISA assay. The present study demonstrates the correlation between mean serum sCR1 concentrations and disease severity in patients with chronic liver disease. In patients with liver cirrhosis, grouped according to the Child-Pugh classification, sCR1 rose as liver function decreased. The presence of neoplastic growth in the liver apparently does not play a role in the increase of sCR1. Serum sCR1 was not elevated in other solid malignancies. Since sCR1 accumulates in liver diseases, evaluation of its serum levels could be useful as a liver function test.

  14. Nuclear reactor with low-level core coolant intake

    DOEpatents

    Challberg, Roy C.; Townsend, Harold E.

    1993-01-01

    A natural-circulation boiling-water reactor has skirts extending downward from control rod guide tubes to about 10 centimeters from the reactor vessel bottom. The skirts define annular channels about control rod drive housings that extend through the reactor vessel bottom. Recirculating water is forced in through the low-level entrances to these channels, sweeping bottom water into the channels in the process. The sweeping action prevents cooler water from accumulating at the bottom. This in turn minimizes thermal shock to bottom-dwelling components as would occur when accumulated cool water is swept away and suddenly replaced by warmer water.

  15. A first-principles core-level XPS study on the boron impurities in germanium crystal

    SciTech Connect

    Yamauchi, Jun; Yoshimoto, Yoshihide; Suwa, Yuji

    2013-12-04

    We systematically investigated the x-ray photoelectron spectroscopy (XPS) core-level shifts and formation energies of boron defects in germanium crystals and compared the results to those in silicon crystals. Both for XPS core-level shifts and formation energies, relationship between defects in Si and Ge is roughly linear. From the similarity in the formation energy, it is expected that the exotic clusters like icosahedral B12 exist in Ge as well as in Si.

  16. A first-principles core-level XPS study on the boron impurities in germanium crystal

    NASA Astrophysics Data System (ADS)

    Yamauchi, Jun; Yoshimoto, Yoshihide; Suwa, Yuji

    2013-12-01

    We systematically investigated the x-ray photoelectron spectroscopy (XPS) core-level shifts and formation energies of boron defects in germanium crystals and compared the results to those in silicon crystals. Both for XPS core-level shifts and formation energies, relationship between defects in Si and Ge is roughly linear. From the similarity in the formation energy, it is expected that the exotic clusters like icosahedral B12 exist in Ge as well as in Si.

  17. The effects of paeoniflorin injection on soluble triggering receptor expressed on myeloid-1 (sTREM-1) levels in severe septic rats

    PubMed Central

    Xu, Jie; Wang, Yi-Min; Ji, Ming-Suo; Liu, Fu-Shan

    2016-01-01

    Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CK-MB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions. PMID:27847433

  18. Detection of subsurface core-level shifts in Si 2p core-level photoemission from Si(111)-(1x1):As

    SciTech Connect

    Paggel, J.J.; Hasselblatt, M.; Horn, K.

    1997-04-01

    The (7 x 7) reconstruction of the Si(111) surface arises from a lowering energy through the reduction of the number of dangling bonds. This reconstruction can be removed by the adsorption of atoms such as hydrogen which saturate the dangling bonds, or by the incorporation of atoms, such as arsenic which, because of the additional electron it possesses, can form three bonds and a nonreactive lone pair orbital from the remaining two electrons. Core and valence level photoemission and ion scattering data have shown that the As atoms replace the top silicon atoms. Previous core level spectra were interpreted in terms of a bulk and a single surface doublet. The authors present results demonstrate that the core level spectrum contains two more lines. The authors assign these to subsurface silicon layers which also experience changes in the charge distribution when a silicon atom is replaced by an arsenic atom. Subsurface core level shifts are not unexpected since the modifications of the electronic structure and/or of photohole screening are likely to decay into the bulk and not just to affect the top-most substrate atoms. The detection of subsurface components suggests that the adsorption of arsenic leads to charge flow also in the second double layer of the Si(111) surface. In view of the difference in atomic radius between As and Si, it was suggested that the (1 x 1): As surface is strained. The presence of charge rearrangement up to the second double layer implies that the atomic coordinates also exhibit deviations from their ideal Si(111) counterparts, which might be detected through a LEED I/V or photoelectron diffraction analysis.

  19. Measures for the Final Common Core of Constructs. The Project on State-Level Child Outcomes.

    ERIC Educational Resources Information Center

    Child Trends, Inc., Washington, DC.

    The Project on State-Level Child Outcomes, a federal project designed to improve the measurement of child outcomes in state welfare evaluations and in other state data systems. This document provides measures for the common core of constructs that state representatives developed at the second national-level meeting of the Project's planning phase.…

  20. Spin polarization and magnetic dichroism in core-level photoemission from ferromagnets

    SciTech Connect

    Menchero, Jose Gabriel

    1997-05-01

    In this thesis we present a theoretical investigation of angle- and spin-resolved core-level photoemission from ferromagnetic Fe and Ni. We also consider magneto-dichroic effects due to reversal of the photon helicity or reversal of the sample magnetization direction. In chapter 1, we provide a brief outline of the history of photoemission, and show how it has played an important role in the development of modern physics. We then review the basic elements of the theory of core-level photoemission, and discuss the validity of the some of the commonly-used approximations. In chapter 2, we present a one-electron theory to calculate spin- and angle-resolved photoemission spectra for an arbitrary photon polarization. The Hamiltonian includes both spin-orbit and exchange interactions. As test cases for the theory, we calculate the spin polarization and magnetic dichroism for the Fe 2p core level, and find that agreement with experiment is very good.

  1. Femtomagnetism in graphene induced by core level excitation of organic adsorbates

    PubMed Central

    Ravikumar, Abhilash; Baby, Anu; Lin, He; Brivio, Gian Paolo; Fratesi, Guido

    2016-01-01

    We predict the induction or suppression of magnetism in the valence shell of physisorbed and chemisorbed organic molecules on graphene occurring on the femtosecond time scale as a result of core level excitations. For physisorbed molecules, where the interaction with graphene is dominated by van der Waals forces and the system is non-magnetic in the ground state, numerical simulations based on density functional theory show that the valence electrons relax towards a spin polarized configuration upon excitation of a core-level electron. The magnetism depends on efficient electron transfer from graphene on the femtosecond time scale. On the other hand, when graphene is covalently functionalized, the system is magnetic in the ground state showing two spin dependent mid gap states localized around the adsorption site. At variance with the physisorbed case upon core-level excitation, the LUMO of the molecule and the mid gap states of graphene hybridize and the relaxed valence shell is not magnetic anymore. PMID:27089847

  2. Assessing Stationarity in Ice Core Record-Sea Level Pressure Relationships for Yukon Territory Ice Core Records

    NASA Astrophysics Data System (ADS)

    Kelsey, E. P.; Wake, C. P.; Osterberg, E. C.

    2014-12-01

    We assess the stationarity of the relationship between Northern Hemisphere winter (Dec-Feb) sea-level pressure (SLP) and proxy time series (major ions, accumulation, and stable isotopes) from the Eclipse (3017 m asl) and the Mt. Logan Prospector-Russell Col (PRCol; 5340 m asl) ice cores from Yukon, Canada. We develop a novel spatial calibration procedure to identify ranges of ice core values that are associated with consistent winter SLP anomaly patterns. Each ice core variable time series was ranked and divided into groups of 13 years each. We assess stationarity by splitting the 1872-2001 analysis period in half (1872-1936 and 1937-2001) and comparing the locations and magnitudes of SLP anomaly patterns during the two periods for each group of ice core values. Northern Hemisphere monthly mean SLP from the 20th Century Reanalysis dataset are used. The high accumulation rate (1.38 m a-1) at Eclipse allows us to analyze 6-month seasonal mean values (Oct-Mar and Apr-Sep), whereas annual mean values are used from PRCol where the accumulation rate is lower (0.40 m a-1). The Eclipse cold season accumulation and PRCol annual mean sodium concentrations (Na+) exhibit the strongest correlations with winter SLP anomaly patterns. In particular, the lowest and highest 20% annual Na+ values at PRCol and lowest 10% cold season accumulation values at Eclipse exhibit stationarity with consistent SLP anomaly patterns in the North Pacific for all three time periods. A weaker Aleutian Low consistently occurred in the central to eastern North Pacific for the lowest Na+ years at PRCol and lowest accumulation cold seasons at Eclipse, although these groups of years are mostly independent. A stronger Aleutian Low occurs in the North Pacific for the highest Na+ years at PRCol. A stationary SLP anomaly pattern is not observed through all three time periods for high cold season accumulation at Eclipse. Application of this calibration procedure with other traditional calibration and

  3. Modeling Shallow Core-Level Transitions in the Reflectance Spectra of Gallium-Containing Semiconductors

    NASA Astrophysics Data System (ADS)

    Stoute, Nicholas; Aspnes, David

    2012-02-01

    The electronic structure of covalent materials is typically approached by band theory. However, shallow core level transitions may be better modeled by an atomic-scale approach. We investigate shallow d-core level reflectance spectra in terms of a local atomic-multiplet theory, a novel application of a theory typically used for higher-energy transitions on more ionic type material systems. We examine specifically structure in reflectance spectra of GaP, GaAs, GaSb, GaSe, and GaAs1-xPx due to transitions that originate from Ga3d core levels and occur in the 20 to 25 eV range. We model these spectra as a Ga^+3 closed-shell ion whose transitions are influenced by perturbations on 3d hole-4p electron final states. These are specifically spin-orbit effects on the hole and electron, and a crystal-field effect on the hole, attributed to surrounding bond charges and positive ligand anions. Empirical radial-strength parameters were obtained by least-squares fitting. General trends with respect to anion electronegativity are consistent with expectations. In addition to the spin-orbit interaction, crystal-field effects play a significant role in breaking the degeneracy of the d levels, and consequently are necessary to understand shallow 3d core level spectra.

  4. Deglacial and lake level fluctuation history recorded in cores, Beaver Lake, Upper Peninsula, Michigan

    USGS Publications Warehouse

    Fisher, Timothy G.; Whitman, Richard L.

    1999-01-01

    Sediment cores collected from the littoral and pelagic zones of Beaver Lake, Michigan record fluctuations in the water level of Lake Superior. Beaver Lake is a small 300 ha lake in Pictured Rocks National Lakeshore (PRNL) now separated from Lake Superior by a dune-capped barrier bar. Cores were collected using a vibracorer from a lake-ice platform in February 1997. A 2.85 m long core in 10 m of water contains well-sorted sand, rhythmites, peat, interbedded sand and gyttja, and is capped with 1 m of massive gyttja. A 9480 BP AMS age from the basal sand provides a minimum deglacial date for the area. Further analysis indicates a sand-dominated depositional environment from a low lake stand at approximately 8500 BP to present. An approximate 8800 BP red to gray sediment color transition records either the cessation of meltwater input from Lake Agassiz or receding ice, while a younger similarly colored transition, 6600 BP in age, likely records sediment reworking in the coastal zone. Four AMS ages on peat range from 8520 to 7340 BP and are indicative of the Houghton low phase. Burial of the peat by stratified sand and gyttja after 7340 BP indicates a rising lake level. Peat at a higher level in the lake basin, encountered in shallow littoral cores, ranges in age from 6800 to 6420 BP, which estimates a 0.91 m rise/century in lake level to the Nipissing level by 5000 BP.

  5. Core and valence level photoemission and photoabsorption study of icosahedral Al Pd Mn quasicrystals

    NASA Astrophysics Data System (ADS)

    Horn, K.; Theis, W.; Paggel, J. J.; Barman, S. R.; Rotenberg, E.; Ebert, Ph; Urban, K.

    2006-01-01

    The electronic structure of quasicrystalline Al-Pd-Mn is investigated by means of valence and core level photoelectron spectroscopy. Variations of the photoionization cross section in the constituents' valence electronic levels as a function of photon energy are used to identify contributions from the different atomic species, in particular near the Pd 4d Cooper minimum. Resonant photoemission at the Mn 2p absorption edge shows the contribution of the Mn 3d states to the density of states in a region near the Fermi level. The asymmetry of Pd 3d and Mn 2p core level photoemission lines, and its difference for emission from metallic and quasicrystalline phases, are utilized to infer the contributions of the different constituents to the density of states at the Fermi level.

  6. Core excitations in (d,p) reactions including transitions to continuum levels

    NASA Astrophysics Data System (ADS)

    Makoto, Tanifuji; Osamu, Mikoshiba; Tokuo, Terasawa

    1982-11-01

    Effects of core excitations in (d, p) reactions are investigated for 12C(d, p) 13C ∗ reactions in the CCBA framework, where couplings of channels are considered for the ground and first-excited levels of 12C in the initial state and for the bound {1}/{2}+and{5}/{2}+ levels and low-lying continuum levels of 13C in the final state, where a discretization is introduced for the continuum region. In the transitions to the continuum levels, matrix elements are calculated by the use of scattering-state wave functions for the final neutron. Theoretical cross sections and vector analyzing powers are compared with experimental data, where significant contributions of core-excitation processes are identified, particularly in the transition to the {5}/{2}+II level of 13C. Spectra of emitted protons are calculated and compared with the measured ones. Adequate agreement between theory and experiment is found throughout the present investigation.

  7. Absolute Binding Energies of Core Levels in Solids from First Principles

    NASA Astrophysics Data System (ADS)

    Ozaki, Taisuke; Lee, Chi-Cheng

    2017-01-01

    A general method is presented to calculate absolute binding energies of core levels in metals and insulators, based on a penalty functional and an exact Coulomb cutoff method in the framework of density functional theory. The spurious interaction of core holes between supercells is avoided by the exact Coulomb cutoff method, while the variational penalty functional enables us to treat multiple splittings due to chemical shift, spin-orbit coupling, and exchange interaction on equal footing, both of which are not accessible by previous methods. It is demonstrated that the absolute binding energies of core levels for both metals and insulators are calculated by the proposed method in a mean absolute (relative) error of 0.4 eV (0.16%) for eight cases compared to experimental values measured with x-ray photoemission spectroscopy within a generalized gradient approximation to the exchange-correlation functional.

  8. Reader Identity and the Common Core: Agency and Identity in Leveled Reading

    ERIC Educational Resources Information Center

    Abodeeb-Gentile, Theresa; Zawilinski, Lisa

    2013-01-01

    This article moves beyond the common core and leveled literacy instruction to demonstrate how diverse learners in one fourth grade classroom, challenged teacher authority in an effort to position themselves as capable readers. In doing so, they implored the teachers to consider the social context of reading as an essential component to the ways in…

  9. Polymers and Cross-Linking: A CORE Experiment to Help Students Think on the Submicroscopic Level

    ERIC Educational Resources Information Center

    Bruce, Mitchell R. M.; Bruce, Alice E.; Avargil, Shirly; Amar, Francois G.; Wemyss, Thomas M.; Flood, Virginia J.

    2016-01-01

    The Polymers and Cross-Linking experiment is presented via a new three phase learning cycle: CORE (Chemical Observations, Representations, Experimentation), which is designed to model productive chemical inquiry and to promote a deeper understanding about the chemistry operating at the submicroscopic level. The experiment is built on two familiar…

  10. Elementary Core Curriculum Standards, Levels K-6. Social Studies. Revised Edition.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City.

    These Utah core standards are designed to help prepare students for the changing times that will require knowledge and skills for living and competition in the information age. Six qualities are emphasized (1) higher level thinking and process skills; (2) citizenship/character practices and principles; (3) basic U.S. values; (4) economic literacy;…

  11. Direct Measurement of Core-Level Relaxation Dynamics on a Surface-Adsorbate System

    NASA Astrophysics Data System (ADS)

    Miaja-Avila, L.; Saathoff, G.; Mathias, S.; Yin, J.; La-O-Vorakiat, C.; Bauer, M.; Aeschlimann, M.; Murnane, M. M.; Kapteyn, H. C.

    2008-07-01

    The coupling between electronic states in a surface-adsorbate system is fundamental to the understanding of many surface interactions. In this Letter, we present the first direct time-resolved observations of the lifetime of core-excited states of an atom adsorbed onto a surface. By comparing laser-assisted photoemission from a substrate with a delayed Auger decay process from an adsorbate, we measure the lifetime of the 4d-1 core level of xenon on Pt(111) to be 7.1±1.1fs. This result opens up time-domain measurements of surface dynamics where energy-resolved measurements may provide incomplete information.

  12. Whisker-reinforced dental core buildup composites: effect of filler level on mechanical properties.

    PubMed

    Xu, H H; Smith, D T; Schumacher, G E; Eichmiller, F C

    2000-12-15

    The strength and toughness of dental core buildup composites in large stress-bearing restorations need to be improved to reduce the incidence of fracture due to stresses from chewing and clenching. The aims of the present study were to develop novel core buildup composites reinforced with ceramic whiskers, to examine the effect of filler level, and to investigate the reinforcement mechanisms. Silica particles were fused onto the whiskers to facilitate silanization and to roughen the whisker surface for improved retention in the matrix. Filler level was varied from 0 to 70%. Flexural strength, compressive strength, and fracture toughness of the composites were measured. A nano-indentation system was used to measure elastic modulus and hardness. Scanning electron microscopy (SEM) was used to examine the fracture surfaces of specimens. Whisker filler level had significant effects on composite properties. The flexural strength in MPa (mean +/- SD; n = 6) increased from (95+/-15) for the unfilled resin to (193+/- 8) for the composite with 50% filler level, then slightly decreased to (176+/-12) at 70% filler level. The compressive strength increased from (149+/-33) for the unfilled resin to (282+/-48) at 10% filler level, and remained equivalent from 10 to 70% filler level. Both the modulus and hardness increased monotonically with filler level. In conclusion, silica particle-fused ceramic single-crystalline whiskers significantly reinforced dental core buildup composites. The reinforcement mechanisms appeared to be crack deflection and bridging by the whiskers. Whisker filler level had significant effects on the flexural strength, compressive strength, elastic modulus, and hardness of composites.

  13. Predicting preferred coring level to reduce toner scatter in electrophotographic printing

    NASA Astrophysics Data System (ADS)

    Park, Hyung Jun; Allebach, Jan P.

    2011-01-01

    The electrophotographic process depends on a complex interplay between electrostatically charged toner particles, the developer roller, and the organic photoconductor during development; and between the toner particles, the organic photoconductor, and the paper during transfer. The task of controlling the imaging process is made even more challenging by the fact that colorant planes are developed independently and in succession. At high colorant levels, toner particles for a given colorant plane may be strongly repelled by toner that has already been deposited for previously developed colorant planes. The result is scattering of toner away from the edges of thin lines and character strokes. In previous work, we have proposed a coring method to reduce the occurrence of the toner scatter, and conducted psychophysical experiments to determine the preferred level of coring as a function of line width and colorant level. In this paper, we apply the edge transition width (ETW) metric to physically measure the impact of toner scatter on the sharpness of edges of lines and character strokes. We consider ETW both with and without coring, and compare it to the results from our earlier psychophysical experiments.

  14. Li induced effects in the core level and π-band electronic structure of graphene grown on C-face SiC

    SciTech Connect

    Johansson, Leif I. Xia, Chao; Virojanadara, Chariya

    2015-11-15

    Studies of the effects induced in the electronic structure after Li deposition, and subsequent heating, on graphene samples prepared on C-face SiC are reported. The as prepared graphene samples are essentially undoped, but after Li deposition, the Dirac point shifts down to 1.2 eV below the Fermi level due to electron doping. The shape of the C 1s level also indicates a doping concentration of around 10{sup 14 }cm{sup −2} after Li deposition, when compared with recent calculated results of core level spectra of graphene. The C 1s, Si 2p, and Li 1s core level results show little intercalation directly after deposition but that most of the Li has intercalated after heating at 280 °C. Heating at higher temperatures leads to desorption of Li from the sample, and at 1030 °C, Li can no longer be detected on the sample. The single π-band observable from multilayer C-face graphene samples in conventional angle resolved photoelectron spectroscopy is reasonably sharp both on the initially prepared sample and after Li deposition. After heating at 280 °C, the π-band appears more diffuse and possibly split. The Dirac point becomes located at 0.4 eV below the Fermi level, which indicates occurrence of a significant reduction in the electron doping concentration. Constant energy photoelectron distribution patterns extracted from the as prepared graphene C-face sample and also after Li deposition and heating at 280 °C look very similar to earlier calculated distribution patterns for monolayer graphene.

  15. EFFECT OF LASER LIGHT ON MATTER. LASER PLASMAS: Identification of transitions from the 1s2l2l'3l'' autoionizing levels of the Be-like Mg IX ion in a plasma heated by a picosecond laser pulse

    NASA Astrophysics Data System (ADS)

    Abdallah, J.; Clark, R. E.; Bryunetkin, B. A.; Skobelev, I. Yu; Faenov, A. Ya; Kalashnikov, M. P.; Nickles, P. V.; Schnurer, M.; Pikuz, S. A.

    1993-12-01

    The x-ray emission spectrum of a magnesium plasma produced by a picosecond laser has been studied. Dielectronic satellites of the resonance line of the He-like Mg XI ion have been identified for the first time. These satellites result from radiative transitions from 1s2l2l'3l'' autoionizing levels of the Be-like Mg IX ion.

  16. Nuclear magnetization distribution radii determined by hyperfine transitions in the 1s level of H-like ions 185Re74+ and 187Re74+

    NASA Astrophysics Data System (ADS)

    Crespo López-Urrutia, J. R.; Beiersdorfer, P.; Widmann, K.; Birkett, B. B.; Mårtensson-Pendrill, A.-M.; Gustavsson, M. G. H.

    1998-02-01

    The F=3 to F=2 hyperfine transitions in the 1s ground state of the two isotopes 185Re74+ and 187Re74+ were measured to be (4560.5+/-3) Å and (4516.9+/-3) Å, respectively, using emission spectroscopy in an electron beam ion trap. After applying appropriate corrections for the nuclear charge distribution and QED effects, a Bohr-Weisskopf effect of ɛ=2.23(9)% and 2.30(9)% are found for 185Re and 187Re, respectively. This value is almost twice that of a previous theoretical estimate, and indicates a distribution of the nuclear magnetization far more extended than that of the nuclear charge. A radius of the magnetization distribution of 1/2=7.57(32) fm and 1/2=7.69(32) fm for 185Re and 187Re, respectively, is inferred from the data. These radii are larger than the nuclear charge distribution radius [1/2=5.39(1) fm] for both isotopes by factors 1.40(6) and 1.43(6), respectively. We find that the Bohr-Weisskopf effect in H-like ions is a sensitive probe of nuclear magnetization distribution, especially for cases where the charge distribution and magnetic moments are accurately known.

  17. Measurement of the radiative lifetime of the 2s(2)2p(4) (1)S(0) metastable level of neon; a study of forbidden transitions of astrophysical interest

    NASA Astrophysics Data System (ADS)

    Daw, Adrian Nigel

    The radiative lifetime of the 2s22 p4 1S0 metastable level of Ne2+ (Ne III) has been measured to be 223 +/- 11 ms at the 90% confidence level by observing the photons emitted at 1815 Å (181.5 nm) by a decaying population of 1 S0 Ne2+ ions stored in a radio frequency ion trap. This thesis describes the first use of a method to account for any ions lost from the trap and determine the radiative lifetime. Metastable ions were produced by electron bombardment of Ne gas, and rate coefficients for Ne2+ + Ne collisions were also determined. The lifetime measurement is in good agreement with recent calculated values, and has a lower uncertainty than the calculated values. This is the first lifetime measurement for an excited term of a ground configuration ion in the second row of the periodic table. The transition probabilities (A-values) for the forbidden transitions in the ground configurations of these ions are required for astrophysical spectral line intensity ratio diagnostics. Using calculated branching ratios, we estimate that, at the 90% confidence level, A(3P1 - 1S0) = 1.94 +/- 0.17 s-1 for the forbidden line of Ne III at 1815 Å, and A(1D2 - 1S0) = 2.55 +/- 0.19 s-1 for the forbidden line of Ne III at 3344 Å.

  18. Gamma-thermometer-based reactor-core liquid-level detector. [PWR

    SciTech Connect

    Burns, T.J.

    1981-06-16

    A system is provided which employs a modified gamma thermometer for determining the liquid coolant level within a nuclear reactor core. The gamma thermometer which normally is employed to monitor local core heat generation rate (reactor power), is modified by thermocouple junctions and leads to obtain an unambiguous indication of the presence or absence of coolant liquid at the gamma thermometer location. A signal processor generates a signal based on the thermometer surface heat transfer coefficient by comparing the signals from the thermocouples at the thermometer location. The generated signal is a direct indication of loss of coolant due to the change in surface heat transfer when coolant liquid drops below the thermometer location. The loss of coolant indication is independent of reactor power at the thermometer location. Further, the same thermometer may still be used for the normal power monitoring function.

  19. Direct measurement of core-level relaxation dynamics on a surface- adsorbate system

    NASA Astrophysics Data System (ADS)

    Yin, Jing; Miaja-Avila, Luis; Saathoff, Guido; La-O-Vorakiat, Chan; Murnane, Margaret; Kapteyn, Henry; Mathias, Stefan; Aeschlimann, Martin; Bauer, Michael

    2008-03-01

    Electronic coupling between an adsorbate and the surface on which it resides is fundamental to the understanding of many surface interactions. However, the interaction of highly-excited adsorbate states is an area that has been explored only indirectly to-date. In this work, we present the first direct time-resolved observations of the lifetime of core-excited states of an atom adsorbed onto a surface. By implementing laser-assisted Auger decay on an adsorbate/surface system, we directly measure the lifetime of the 4d-1 core level of Xenon on Pt(111) to be 7.1 ± 1.1 fs. This result opens up time domain measurements of highly-excited state dynamics in materials systems where, because of complex interactions, energy-resolved measurements provide incomplete information.

  20. Direct measurement of core-level relaxation dynamics on a surface- adsorbate system

    NASA Astrophysics Data System (ADS)

    Yin, Jing; Miaja-Avila, Luis; Saathoff, Guido; La-O-Vorakiat, Chan; Murnane, Margaret; Kapteyn, Henry; Mathias, Stefan; Aeschlimann, Martin; Bauer, Michael

    2008-05-01

    Electronic coupling between an adsorbate and the surface on which it resides is fundamental to the understanding of many surface interactions. However, the interaction of highly-excited adsorbate states is an area that has been explored only indirectly to-date. In this work, we present the first direct time-resolved observations of the lifetime of core-excited states of an atom adsorbed onto a surface. By implementing laser-assisted Auger decay on an adsorbate/surface system, we directly measure the lifetime of the 4d-1 core level of Xenon on Pt(111) to be 7.1 ± 1.1 fs. This result opens up time domain measurements of highly-excited state dynamics in materials systems where, because of complex interactions, energy-resolved measurements provide incomplete information.

  1. Lifetime of the 1s2s 3S1 metastable level in He-like S14+ measured with an electron beam ion trap

    SciTech Connect

    L?pez-Urrutia, J C; Beiersdorfer, P; Widmann, K

    2006-03-16

    A precision measurement of the lifetime of the lowest exited level of the He-like S{sup 14+} ion carried out at the Livermore EBIT-II electron beam ion trap yielded a value of (703 {+-} 4) ns. Our method extends the range of lifetime measurements accessible with electron beam ion traps into the nanosecond region and improves the accuracy of currently available data for this level by an order of magnitude.

  2. Identifying heavy metal levels in historical flood water deposits using sediment cores.

    PubMed

    Lintern, Anna; Leahy, Paul J; Heijnis, Henk; Zawadzki, Atun; Gadd, Patricia; Jacobsen, Geraldine; Deletic, Ana; Mccarthy, David T

    2016-11-15

    When designing mitigation and restoration strategies for aquatic systems affected by heavy metal contamination, we must first understand the sources of these pollutants. In this study, we introduce a methodology that identifies the heavy metal levels in floodplain lake sediments deposited by one source; fluvial floods. This is done by comparing sediment core heavy metal profiles (i.e., historical pollution trends) to physical and chemical properties of sediments in these cores (i.e., historical flooding trends). This methodology is applied to Willsmere and Bolin Billabongs, two urban floodplain lakes (billabongs) of the Yarra River (South-East Australia). Both billabongs are periodically inundated by flooding of the Yarra River and one billabong (Willsmere Billabong) is connected to an urban stormwater drainage network. 1-2-m long sediment cores (containing sediment deposits up to 500 years old) were taken from the billabongs and analysed for heavy metal concentrations (arsenic, chromium, copper, lead, nickel, zinc). In cores from both billabongs, arsenic concentrations are high in the flood-borne sediments. In Bolin Billabong, absolute metal levels are similar in flood and non-flood deposits. In Willsmere Billabong, absolute copper, lead and zinc levels were generally lower in fluvial flood-borne sediments in the core compared to non-fluvial sediments. This suggests that heavy metal concentrations in Bolin Billabong sediments are relatively similar regardless of whether or not fluvial flooding is occurring. However for Willsmere Billabong, heavy metal concentrations are high when overland runoff, direct urban stormwater discharges or atmospheric deposition is occurring. As such, reducing the heavy metal concentrations in these transport pathways will be of great importance when trying to reduce heavy metal concentrations in Willsmere Billabong sediments. This study presents a proof-of-concept that can be applied to other polluted aquatic systems, to understand the

  3. Ultra-sensitive Flow Injection Analysis (FIA) determination of calcium in ice cores at ppt level.

    PubMed

    Traversi, R; Becagli, S; Castellano, E; Maggi, V; Morganti, A; Severi, M; Udisti, R

    2007-07-02

    A Flow Injection Analysis (FIA) spectrofluorimetric method for calcium determination in ice cores was optimised in order to achieve better analytical performances which would make it suitable for reliable calcium measurements at ppt level. The method here optimised is based on the formation of a fluorescent compound between Ca and Quin-2 in buffered environment. A careful evaluation of operative parameters (reagent concentration, buffer composition and concentration, pH), influence of interfering species possibly present in real samples and potential favourable effect of surfactant addition was carried out. The obtained detection limit is around 15 ppt, which is one order of magnitude lower than the most sensitive Flow Analysis method for Ca determination currently available in literature and reproducibility is better than 4% for Ca concentrations of 0.2 ppb. The method was validated through measurements performed in parallel with Ion Chromatography on 200 samples from an alpine ice core (Lys Glacier) revealing an excellent fit between the two chemical series. Calcium stratigraphy in Lys ice core was discussed in terms of seasonal pattern and occurrence of Saharan dust events.

  4. Production Level CFD Code Acceleration for Hybrid Many-Core Architectures

    NASA Technical Reports Server (NTRS)

    Duffy, Austen C.; Hammond, Dana P.; Nielsen, Eric J.

    2012-01-01

    In this work, a novel graphics processing unit (GPU) distributed sharing model for hybrid many-core architectures is introduced and employed in the acceleration of a production-level computational fluid dynamics (CFD) code. The latest generation graphics hardware allows multiple processor cores to simultaneously share a single GPU through concurrent kernel execution. This feature has allowed the NASA FUN3D code to be accelerated in parallel with up to four processor cores sharing a single GPU. For codes to scale and fully use resources on these and the next generation machines, codes will need to employ some type of GPU sharing model, as presented in this work. Findings include the effects of GPU sharing on overall performance. A discussion of the inherent challenges that parallel unstructured CFD codes face in accelerator-based computing environments is included, with considerations for future generation architectures. This work was completed by the author in August 2010, and reflects the analysis and results of the time.

  5. Optical properties of solid core honeycomb photonic crystal fiber with different doping levels

    NASA Astrophysics Data System (ADS)

    Xu, Guangyu; Zhang, Wei; Huang, Yidong; Peng, Jiangde

    2006-01-01

    Group velocity dispersion (GVD) and effective mode area (Aeff) of solid core honeycomb cladding photonic crystal fiber (PCF) with different up/down doping levels are investigated theoretically. Both total internal reflection (TIR) and photonic bandgap (PBG) guiding mechanisms are shown to be available in this fiber structure with gradual change of the doping level. It is noted that the previously overlooked TIR guiding design with up-doping could acquire improved nonlinear property compared with PBG mechanism in short normalized wavelength region. On the other hand, the total GVD is shown to be dominated by waveguide dispersion corresponding to the fiber structure. Numerical results show that HPCF can achieve small Aeff with low air-fill fraction, and doping level in HPCF provides an additional way to change GVD excepting structure parameters. Special cases are given to demonstrate the potential of HPCF in combining design of Aeff and GVD, aiming at applications such as Raman amplification and dispersion compensation around 1550nm.

  6. Symmetry rules in magnetic core-level photoelectron spectroscopy from epitaxial ferromagnetic ultrathin films

    NASA Astrophysics Data System (ADS)

    Schellenberg, R.; Meinert, H.; Perez, A.; Kisker, E.

    2001-09-01

    For two x-ray incidence directions onto an epitaxial FeNi(001) film, one to the left and a second one to the right side of the symmetry plane spanned by the magnetization direction and the photoelectron wave vector, we have measured distributions of the emission-angle dependence with respect to the crystallographic axes of the Fe 2p3/2 core-level photoelectron intensity asymmetry occurring upon magnetization reversal. The two angular distributions transform into each other when the signs of the magnetization and of the photoelectron emission angle are inverted, in accordance with the conservation of parity.

  7. Photoemission core-level shifts reveal the thiolate-Au(111) interface

    SciTech Connect

    Groenbeck, Henrik; Odelius, Michael

    2010-08-15

    The nature of the thiolate/Au(111) interface is a long-standing puzzle. It has been suggested that thiolates drive surface reconstruction, however, a consensus regarding the adsorption configuration is missing. Herein, the density-functional theory is used to evaluate surface core-level shifts (SCLSs) for methyl thiolates on Au(111) assuming a representative set of different surface reconstructions. The SCLSs are found to provide sensitive fingerprints of the anchoring configuration, and it is only thiolate adsorption in the form of MeS-Au-SMe complexes that can be reconciled with experimental data.

  8. Quanty for core level spectroscopy - excitons, resonances and band excitations in time and frequency domain

    NASA Astrophysics Data System (ADS)

    Haverkort, Maurits W.

    2016-05-01

    Depending on the material and edge under consideration, core level spectra manifest themselves as local excitons with multiplets, edge singularities, resonances, or the local projected density of states. Both extremes, i.e., local excitons and non-interacting delocalized excitations are theoretically well under control. Describing the intermediate regime, where local many body interactions and band-formation are equally important is a challenge. Here we discuss how Quanty, a versatile quantum many body script language, can be used to calculate a variety of different core level spectroscopy types on solids and molecules, both in the frequency as well as the time domain. The flexible nature of Quanty allows one to choose different approximations for different edges and materials. For example, using a newly developed method merging ideas from density renormalization group and quantum chemistry [1-3], Quanty can calculate excitons, resonances and band-excitations in x-ray absorption, photoemission, x-ray emission, fluorescence yield, non-resonant inelastic x-ray scattering, resonant inelastic x-ray scattering and many more spectroscopy types. Quanty can be obtained from: http://www.quanty.org.

  9. Core level excitations—A fingerprint of structural and electronic properties of epitaxial silicene

    SciTech Connect

    Friedlein, R. Fleurence, A.; Aoyagi, K.; Yamada-Takamura, Y.; Jong, M. P. de; Van Bui, H.; Wiggers, F. B.; Yoshimoto, S.; Koitaya, T.; Shimizu, S.; Noritake, H.; Mukai, K.; Yoshinobu, J.

    2014-05-14

    From the analysis of high-resolution Si 2p photoelectron and near-edge x-ray absorption fine structure (NEXAFS) spectra, we show that core level excitations of epitaxial silicene on ZrB{sub 2}(0001) thin films are characteristically different from those of sp{sup 3}-hybridized silicon. In particular, it is revealed that the lower Si 2p binding energies and the low onset in the NEXAFS spectra as well as the occurrence of satellite features in the core level spectra are attributed to the screening by low-energy valence electrons and interband transitions between π bands, respectively. The analysis of observed Si 2p intensities related to chemically distinct Si atoms indicates the presence of at least one previously unidentified component. The presence of this component suggests that the observation of stress-related stripe domains in scanning tunnelling microscopy images is intrinsically linked to the relaxation of Si atoms away from energetically unfavourable positions.

  10. The Systems Biology Markup Language (SBML) Level 3 Package: Layout, Version 1 Core.

    PubMed

    Gauges, Ralph; Rost, Ursula; Sahle, Sven; Wengler, Katja; Bergmann, Frank Thomas

    2015-09-04

    Many software tools provide facilities for depicting reaction network diagrams in a visual form. Two aspects of such a visual diagram can be distinguished: the layout (i.e.: the positioning and connections) of the elements in the diagram, and the graphical form of the elements (for example, the glyphs used for symbols, the properties of the lines connecting them, and so on). For software tools that also read and write models in SBML (Systems Biology Markup Language) format, a common need is to store the network diagram together with the SBML representation of the model. This in turn raises the question of how to encode the layout and the rendering of these diagrams. The SBML Level 3 Version 1 Core specification does not provide a mechanism for explicitly encoding diagrams, but it does provide a mechanism for SBML packages to extend the Core specification and add additional syntactical constructs. The Layout package for SBML Level 3 adds the necessary features to SBML so that diagram layouts can be encoded in SBML files, and a companion package called SBML Rendering specifies how the graphical rendering of elements can be encoded. The SBML Layout package is based on the principle that reaction network diagrams should be described as representations of entities such as species and reactions (with direct links to the underlying SBML elements), and not as arbitrary drawings or graphs; for this reason, existing languages for the description of vector drawings (such as SVG) or general graphs (such as GraphML) cannot be used.

  11. Core-level photoemission from nanocluster-matrix composites: Au clusters in amorphous carbon

    NASA Astrophysics Data System (ADS)

    Calliari, L.; Minati, L.; Speranza, G.; Paris, A.; Baranov, A.; Fanchenko, S.

    2014-09-01

    We investigate a system consisting of Au nano-clusters and amorphous carbon (a-C) via core-level photoemission. While the ability of photoemission to characterize nano-sized metal clusters is well-known, still some issues deserve investigation. For example, the well-established dominance of final-state relaxation effects in core-level spectra from nano-clusters necessarily involves a crucial role of the cluster dielectric-environment. To the best of our knowledge however, a thorough discussion on this point is lacking. We thus intend to investigate dielectric-environment effects by considering several configurations for Au clusters, i.e. supported and embedded, with the latter obtained either by depositing a-C on top of supported clusters or by co-depositing a-C and Au. We analyze the Au4 f spectrum from clusters accounting for both cluster size and cluster location with respect to the a-C matrix. We show that spectral changes caused by a-C deposition are entirely explained in terms of changes in the cluster dielectric environment. Moreover, we prove that supported clusters are in a well-characterized dielectric environment, while embedded clusters are not. This is because embedded clusters, whatever the method of production, are spatially distributed over the matrix surface-region which is characterized by rapid fluctuations in the dielectric constant.

  12. Quantum and classical dynamics of H + CaCl(X (2)Σ(+)) → HCl + Ca((1)S) reaction and vibrational energy levels of the HCaCl complex.

    PubMed

    Tan, Rui Shan; Zhai, Huan Chen; Gao, Feng; Tong, Dianmin; Lin, Shi Ying

    2016-06-21

    We carried out accurate quantum wave packet as well as quasi-classical trajectory (QCT) calculations for H + CaCl (νi = 0, ji = 0) reaction occurring on an adiabatic ground state using the recent ab initio potential energy surface to obtain the quantum and QCT reaction probabilities for several partial waves (J = 0, 10, and 20) as well as state resolved QCT integral and differential cross sections. The complete list of vibrational energy levels supported by the intermediate HCaCl complex is also obtained using the Lanczos algorithm. The QCT reaction probabilities show excellent agreement with the quantum ones except for the failure in reproducing the highly oscillatory resonance structure. Despite the fact that the reaction is exothermic and the existence of a barrier that is energetically lower than the bottom of the reactant valley, the reaction probability for J = 0 shows threshold-like behavior and the reactivity all through the energies is very low (<0.1). The dynamical features at two different energy regions (<0.35 eV and >0.35 eV) are found to be different drastically from each other. The analyses of these results suggest that the reaction is governed by one of the two different types of reaction mechanism, one is the direct mechanism at the high energy region and the other is the indirect mechanism at the low energy region by which the reaction proceeds through the long-lived intermediate complex followed by a statistical dissociation into asymptotic channels.

  13. Relativistic electron correlation, quantum electrodynamics, and the lifetime of the 1s(2)2s(2)2p2p0(3/2) level in boronlike argon.

    PubMed

    Lapierre, A; Jentschura, U D; Crespo López-Urrutia, J R; Braun, J; Brenner, G; Bruhns, H; Fischer, D; González Martínez, A J; Harman, Z; Johnson, W R; Keitel, C H; Mironov, V; Osborne, C J; Sikler, G; Soria Orts, R; Shabaev, V; Tawara, H; Tupitsyn, I I; Ullrich, J; Volotka, A

    2005-10-28

    The lifetime of the Ar13+ 1s(2)2s(2)2p2p0(3/2) metastable level was determined at the Heidelberg Electron Beam Ion Trap to be 9.573(4)(5). The accuracy level of one per thousand makes this measurement sensitive to quantum electrodynamic effects like the electron anomalous magnetic moment (EAMM) and to relativistic electron-electron correlation effects like the frequency-dependent Breit interaction. Theoretical predictions, adjusted for the EAMM, cluster about a lifetime that is approximately shorter than our experimental result.

  14. Pressure-induced crossing of the core levels in 5 d metals

    NASA Astrophysics Data System (ADS)

    Tal, Alexey A.; Katsnelson, Mikhail I.; Ekholm, Marcus; Jönsson, H. Johan M.; Dubrovinsky, Leonid; Dubrovinskaia, Natalia; Abrikosov, Igor A.

    2016-05-01

    A pressure-induced interaction between core electrons, the core-level crossing (CLC) transition, has been observed in hcp Os at P ≈400 GPa [L. Dubrovinsky et al., Nature (London) 525, 226 (2015)], 10.1038/nature14681. By carrying out a systematic theoretical study for all metals of the 5 d series (Hf, Ta, W, Re, Os, Ir, Pt, Au) we have found that the CLC transition is a general effect for this series of metals. While in Pt it occurs at ≈1500 GPa , at a pressure substantially higher than in Os, in Ir it occurs already at 80 GPa. Moreover, we predict that in Re the CLC transition may take place already at ambient pressure. We explain the effect of the CLC and analyze the shift of the transition pressure across the series within the Thomas-Fermi model. In particular, we show that the effect has many common features with the atomic collapse in rare-earth elements.

  15. Exciton and core-level electron confinement effects in transparent ZnO thin films

    PubMed Central

    Mosquera, Adolfo A.; Horwat, David; Rashkovskiy, Alexandr; Kovalev, Anatoly; Miska, Patrice; Wainstein, Dmitry; Albella, Jose M.; Endrino, Jose L.

    2013-01-01

    The excitonic light emission of ZnO films have been investigated by means of photoluminescence measurements in ultraviolet-visible region. Exciton confinement effects have been observed in thin ZnO coatings with thickness below 20 nm. This is enhanced by a rise of the intensity and a blue shift of the photoluminescence peak after extraction of the adsorbed species upon annealing in air. It is found experimentally that the free exciton energy (determined by the photoluminescence peak) is inversely proportional to the square of the thickness while core-level binding energy is inversely proportional to the thickness. These findings correlate very well with the theory of kinetic and potential confinements.

  16. Physics of the Be(10{bar 1} 0) Surface Core Level Spectrum

    SciTech Connect

    Lizzit, S.; Pohl, K. |; Baraldi, A.; Comelli, G.; Fritzsche, V.; Plummer, E.W. |; Stumpf, R.; Hofmann, P. ||

    1998-10-01

    Photoelectron diffraction has been utilized to confirm the theoretical prediction that the surface core level shifts observed for Be(10{bar 1}0) have been improperly assigned. The original assignment based upon the relative intensity of the shifted components was intuitively obvious: the peak with the largest shift of {minus}0.7 eV with respect to the bulk was associated with the surface plane, the next peak shifted by {minus}0.5 eV stems from the second layer, and the third peak at {minus}0.22 eV from the third and fourth layers. First-principles theory and our experimental data show that the largest shift is associated with the second plane, not the first plane. {copyright} {ital 1998} {ital The American Physical Society }

  17. Er/Si (111) interface intermixing investigation using core level photoemission

    SciTech Connect

    Haderbache, L.; Wetzel, P.; Pirri, C.; Peruchetti, J.C.; Bolmont, D.; Gewinner, G. )

    1990-07-23

    We present in this letter Si 2{ital p} core level photoemission measurements on the Er/Si (111) interface formed at room temperature. These spectroscopic data are compared with those measured on amorphous silicide films for various Er concentrations grown by coevaporation of Er and Si species at room temperature under ultrahigh vacuum conditions. This study reveals a strong interaction between Er and the Si (111) substrate even at very low coverage. A mixed interface is observed with silicide formation up to 6 monolayers of deposited metal which corresponds to the onset of erbium metal overgrowth. The Er concentration in the interfacial silicide is found to increase as a function of the deposited Er thickness. A model for the interface is proposed and discussed.

  18. Characterization of tuyere-level core-drill coke samples from blast furnace operation

    SciTech Connect

    S. Dong; N. Paterson; S.G. Kazarian; D.R. Dugwell; R. Kandiyoti

    2007-12-15

    A suite of tuyere-level coke samples have been withdrawn from a working blast furnace during coal injection, using the core-drilling technique. The samples have been characterized by size exclusion chromatography (SEC), Fourier transform Raman spectroscopy (FT-RS), and X-ray powder diffraction (XRD) spectroscopy. The 1-methyl-2-pyrrolidinone (NMP) extracts of the cokes sampled from the 'bosh', the rear of the 'bird's nest', and the 'dead man' zones were found by SEC to contain heavy soot-like materials (ca. 10{sup 7}-10{sup 8} apparent mass units). In contrast, NMP extracts of cokes taken from the raceway and the front of the 'bird's nest' only contained a small amount of material of relatively lower apparent molecular mass (up to ca. 10{sup 5} u). Since the feed coke contained no materials extractable by the present method, the soot-like materials are thought to have formed during the reactions of volatile matter released from the injectant coal, probably via dehydrogenation and repolymerization of the tars. The Raman spectra of the NMP-extracted core-drilled coke samples showed variations reflecting their temperature histories. Area ratios of D-band to G-band decreased as the exposure temperature increased, while intensity ratios of D to G band and those of 2D to G bands increased with temperature. The graphitic (G), defect (D), and random (R) fractions of the carbon structure of the cokes were also derived from the Raman spectra. The R fractions decreased with increasing temperature, whereas G fractions increased, while the D fractions showed a more complex variation with temperature. These data appear to give clues regarding the graphitization mechanism of tuyere-level cokes in the blast furnace. 41 refs., 9 figs., 6 tabs.

  19. Core-level electronic structure of solid-phase glycine, glycyl-glycine, diglycyl-glycine, and polyglycine: X-ray photoemission analysis and Hartree-Fock calculations of their zwitterions.

    PubMed

    Chatterjee, Avisek; Zhao, Liyan; Zhang, Lei; Pradhan, Debabrata; Zhou, Xiaojing; Leung, K T

    2008-09-14

    X-ray photoelectron spectroscopy (XPS) has been used to investigate the core-level electronic structures of glycine (G) and its peptides, including glycyl-glycine (GG), diglycyl-glycine (GGG), and polyglycine (poly-G), in their powder forms. Increasing the number of G units in the peptides does not change the locations of the respective C 1s, N 1s, and O 1s features corresponding to different functional groups: -COO(-), -NH(3)(+), >CH(2), and -CONH-. The electronic structures of the zwitterions of these molecules have been calculated as isolated molecules and as molecules in an aqueous environment under the periodic boundary conditions by quantum-mechanical and molecular mechanics methods. In the case of glycine zwitterion, the binding energies of the C 1s, N 1s, and O 1s XPS features are found to be in reasonable accord with the respective orbital energies obtained by Hartree-Fock self-consistent-field calculations, within the context of Koopmans' approximation. However, considerably worse agreement in the binding energies is found for the larger zwitterions (with the specific conformations considered in this work), indicating the need for higher-level calculations. The present work shows that optimizing the zwitterion in an aqueous environment under the periodic boundary conditions by molecular mechanics could be a very cost-effective approach for calculating the electronic structures of large, complex biomolecular systems.

  20. Gamma Spectra Resulting From the Annihilation of Positrons with Electrons in Single, Selected Core Levels of Cu, Ag and Au

    SciTech Connect

    Kim, S; Eshed, A; Goktepeli, S; Sterne, P A; Koymen, A R; Chen, W C; Weiss, A H

    2005-07-25

    The {gamma}-ray energy spectra due to positron annihilation with the 3p core-level of Cu, the 4p core-level of Ag, and 5p core level of Au were obtained separately from the total annihilation spectrum by measuring the energies of {gamma}-rays time coincident with Auger electrons emitted as a result of filling the core-hole left by annihilation. The results of these measurements are compared to the total annihilation spectra and with LDA based theoretical calculations. A comparison of area normalized momentum distributions with the individual cores extracted from the Doppler measurements shows good qualitative agreement, however, in all three spectra, the calculated values of the momentum density appears to fall below the measured values as the momentum increases. The discrepancies between theory and experiment are well outside the statistical uncertainties of the experiment and become more pronounced with increasing Z going down the column from Cu to Ag to Au. The comparison with the experimental results clearly indicates that the calculations are not predicting the correct ratio of high momentum to low momentum spectral weight and suggest the need to improve the treatment of many body electron-positron correlation effects in annihilation as they pertain to core levels.

  1. Application of high-resolution photoelectron spectroscopy: Vibrational resolved C 1s and O 1s spectra of CO adsorbed on Ni(100)

    SciTech Connect

    Foehlisch, A.; Nilsson, A.; Martensson, N.

    1997-04-01

    There are various effects which determine the line shape of a core-level electron spectrum. These are due to the finite life-time of the core hole, inelastic scattering of the outgoing photoelectron, electronic shake-up and shake-off processes and vibrational excitations. For free atoms and molecules the different contributions to the observed line shapes can often be well separated. For solids, surfaces and adsorbates the line shapes are in general much broader and it has in the past been assumed that no separation of the various contributions can be made. In the present report the authors will show that this is indeed not the case. Surprisingly, the vibrational fine structure of CO adsorbed on Ni(100) can be resolved in the C 1s and O 1s electron spectra. This was achieved by the combination of highly monochromatized soft X-rays from B18.0 with a high resolution Scienta 200 mm photoelectron spectrometer. X-ray photoelectron spectroscopy (XPS) with tunable excitation energy yields as a core level spectroscopy atomic and site-specific information. The presented measurements allow for a determination of internuclear distances and potential energy curves in corehole ionized adsorbed molecules. The authors analysis of the c(2x2) phase CO/Ni(100) on {open_quotes}top{close_quotes} yielded a vibrational splitting of 217 +/- 2 meV for C 1s ionization. For O 1s ionization a splitting of 173 +/- 8 meV was found.

  2. Raising FLAGS: Renewing Core French at the Pre-Service Teacher Level

    ERIC Educational Resources Information Center

    Carr, Wendy

    2010-01-01

    A new program for core French teacher candidates called FLAGS (French Language and Global Studies) was established at the University of British Columbia (UBC) in 2007. The program is intended for those who are keen to teach core French and possess rudimentary proficiency in the language but may not necessarily have the same proficiency or prior…

  3. Promoting integration of genetics core competencies into entry-level nursing curricula.

    PubMed

    Read, Catherine Y; Dylis, Ann M; Mott, Sandra R; Fairchild, Nancy J

    2004-08-01

    Nurse educators must respond to the growing need to teach genetics content in undergraduate nursing curricula. Recently developed genetics core competencies can be used to guide curriculum assessment and planning. This article describes a 5-year effort to integrate genetics education into a baccalaureate nursing curriculum and provides the results of a curriculum survey based on published genetics core competencies.

  4. Calculation of core-level excitation in some MAX-phase compounds

    NASA Astrophysics Data System (ADS)

    Wang, Liaoyuan; Rulis, Paul; Ching, W. Y.

    2013-07-01

    We report first-principles spectroscopic calculation of core level excitations in five MAX-phase compounds. The spectra of Ti-K edges in Ti2AlC and Ti2AlN, C-K edge in Ti2AlC, N-K edge in Ti2AlN, and Nb-K edge in Nb2AlC are calculated and found to be in good agreement with reported experimental measurements. Based on this agreement, the Al-K and Al-L3 edges in the same five phases plus the Cr-K and C-K edges in Cr2AlC and the C-K edge in Nb2AlC are calculated as theoretical predictions. We further analyze the anisotropy in the calculated spectra to gain additional insights on the structure-properties relationships in these MAX-phase compounds. These results are further discussed in the context of the local atomic environments of the M, A, and X elements in MAX-phase compounds and in relation to their fundamental electronic structures.

  5. Core level electron binding energies of realgar (As{sub 4}S{sub 4})

    SciTech Connect

    Pratt, A.R.; Nesbitt, H.W.

    2000-04-01

    XPS broad scans and high-resolution narrow-region spectra were collected from fresh realgar (As{sub 4}S{sub 4}) surfaces to measure core level S and As binding energies. Reasonably accurate As and S concentrations were determined from XPS broad scans using peak areas and manufacturer supplied sensitivity factors. High resolution S(2p) and As(3d) narrow region spectra were comprised of photoelectron emissions indicative of As and S in intermediate oxidation states akin to binding energies of As and S polymeric species. S(2p) spectra were interpreted using only S contributions expected from the bulk mineral matrix and showed that S was not greatly affected by surface state phenomena. This was attributed to breakage of intermolecular van der Waals bonds rather than covalent interatomic bonds. As(3d) spectra were found to contain two contributions one from As atoms in As{sub 4}S{sub 4} molecules in the bulk mineral matrix and another possibly from As atoms in molecules situated at the surface.

  6. The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core.

    PubMed

    Hucka, Michael; Bergmann, Frank T; Hoops, Stefan; Keating, Sarah M; Sahle, Sven; Schaff, James C; Smith, Lucian P; Wilkinson, Darren J

    2015-09-04

    Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

  7. Intermediate coupling for core-level excited states: Consequences for X-Ray absorption spectroscopy

    SciTech Connect

    Bagus, Paul S.; Sassi, Michel J.; Rosso, Kevin M.

    2015-04-01

    The origin of the complex NEXAFS features of X-Ray Absorption, XAS, spectra in transition metal complexes is analyzed and interpreted in terms of the angular momentum coupling of the open shell electrons. Especially for excited configurations where a core-electron is promoted to an open valence shell, the angular momentum coupling is intermediate between the two limits of Russell- Saunders, RS, coupling where spin-orbit splitting of the electron shells is neglected and j-j coupling where this splitting is taken as dominant. The XAS intensities can be understood in terms of two factors: (1) The dipole selection rules that give the allowed excited RS multiplets and (2) The contributions of these allowed multiplets to the wavefunctions of the intermediate coupled levels. It is shown that the origin of the complex XAS spectra is due to the distribution of the RS allowed multiplets over several different intermediate coupled excited levels. The specific case that is analyzed is the L2,3 edge XAS of an Fe3+ cation, because this cation allows a focus on the angular momentum coupling to the exclusion of other effects; e.g., chemical bonding. Arguments are made that the properties identified for this atomic case are relevant for more complex materials. The analysis is based on the properties of fully relativistic, ab initio, many-body wavefunctions for the initial and final states of the XAS process. The wavefunction properties considered include the composition of the wavefunctions in terms of RS multiplets and the occupations of the spin-orbit split open shells; the latter vividly show whether the coupling is j-j or not.

  8. Engineering task plan for upgrades to the leveling jacks on core sample trucks number 3 and 4

    SciTech Connect

    KOSTELNIK, A.J.

    1999-02-24

    Characterizing the waste in underground storage tanks at the Hanford Site is accomplished by obtaining a representative core sample for analysis. Core sampling is one of the numerous techniques that have been developed for use given the environmental and field conditions at the Hanford Site. Core sampling is currently accomplished using either Push Mode Core Sample Truck No.1 or; Rotary Mode Core Sample Trucks No.2, 3 or 4. Past analysis (WHC 1994) has indicated that the Core Sample Truck (CST) leveling jacks are structurally inadequate when lateral loads are applied. WHC 1994 identifies many areas where failure could occur. All these failures are based on exceeding the allowable stresses listed in the American Institute of Steel Construction (AISC) code. The mode of failure is for the outrigger attachments to the truck frame to fail resulting in dropping of the CST and possible overturning (Ref. Ziada and Hundal, 1996). Out of level deployment of the truck can exceed the code allowable stresses in the structure. Calculations have been performed to establish limits for maintaining the truck level when lifting. The calculations and the associated limits are included in appendix A. The need for future operations of the CSTS is limited. Sampling is expected to be complete in FY-2001. Since there is limited time at risk for continued use of the CSTS with the leveling controls without correcting the structural problems, there are several design changes that could give incremental improvements to the operational safety of the CSTS with limited impact on available operating time. The improvements focus on making the truck easier to control during lifting and leveling. Not all of the tasks identified in this ETP need to be performed. Each task alone can improve the safety. This engineering task plan is the management plan document for implementing the necessary additional structural analysis. Any additional changes to meet requirements of standing orders shall require a

  9. Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes.

    PubMed

    Glowinska, Barbara; Urban, Miroslawa; Peczynska, Jadwiga; Florys, Bozena

    2005-08-01

    The attachment of monocytes and lymphocytes to endothelial cells, which initiates atherosclerosis, arises under the influence of adhesion molecules. The preclinical phase of this disease lasts many decades, and this provides an opportunity for the presymptomatic detection of high-risk subjects. We evaluated levels of the adhesion molecules: sICAM-1 (soluble intercellular adhesion molecule 1), sVCAM-1 (soluble vascular adhesion molecule 1), sE selectin, sP selectin, and sL selectin in children with atherosclerosis risk factors (n = 123, mean age 15.1 years) (obese [n = 17], hypertensive [n = 25], obese with hypertension [n = 30], type 1 diabetic [n = 51]). Twenty-seven healthy children formed the control group, mean age 15.2 years. sICAM-1 was higher in the study group compared with control (314.1 +/- 61 vs 264.9 +/- 55 ng/mL, P < .01). The same was found for sVCAM-1 (513.7 +/- 187 vs 407.9 +/- 76 ng/mL, P < .05) and E selectin (86.04 +/- 33.6 vs 62.1 +/- 20.3 ng/mL, P < .01). sP-selectin and sL-selectin levels were not different compared with controls. E selectin correlated with body mass index (BMI; r = 0.18, P = .03), total cholesterol (r = 0.2, P = .016), and triglycerides (r = 0.22, P = .008). sICAM-1 correlated with BMI (r = 0.19, P = .019) and systolic blood pressure (r = 0.13, P = .045). In multiple linear regression analysis, sE selectin was found to be associated with triglycerides (R2 = 0.29, P = .045), sICAM-1 dependent on BMI (R2 = 0.58, P = .047), and sVCAM-1 dependent on total cholesterol (R2 = 0.51, P = .006). Elevated concentrations of sICAM-1, sVCAM-1, and E selectin were found in obese, hypertensive, and diabetic children. We conclude that endothelial activation appears in these children, and adhesion molecules are related to the earliest stages of atherosclerosis.

  10. Energy levels, Auger branching ratios, and radiative rates of the core-excited states of B-like carbon

    SciTech Connect

    Sun Yan; Gou Bingcong; Chen Feng

    2011-09-28

    Energy levels, Auger branching ratios, and radiative rates of the core-excited states of B-like carbon are calculated by the saddle-point variation and saddle-point complex-rotation methods. Relativistic and mass polarization corrections are included using first-order perturbation theory. Calculated Auger channel energies and branching ratios are used to identify high-resolution Auger spectrum in the 300-keV C{sup +}{yields} CH{sub 4} collision experiment. It is found that Auger decay of these five-electron core-excited states gives significant contributions to Auger spectrum in the range of 238-280 eV.

  11. 1024 x 768 XGA uncooled camera core achieves new levels of performance in a small package

    NASA Astrophysics Data System (ADS)

    Alicandro, C. J.; DeMarco, R. W.

    2011-06-01

    An uncooled XGA camera core has been developed for multiple thermal imaging applications that require longer detection range and wider fields of view. The design challenge is to maintain high performance while optimizing for size, weight, and power (SWAP). Utilizing a combination of low power electronic designs, proprietary calibration methods, and a new 17μm pitch high performance amorphous silicon (ASi) microbolometer, a rugged multi-purpose SWAP-optimized XGA camera core has been designed. The result is a camera core that has been shown to deliver far better detection range and angle-of-view performance than previous uncooled solutions with frame rates of 30 Hz in XGA mode and 60 Hz in VGA mode.

  12. Core sampling beneath low-level radioactive-waste burial trenches, West Valley, Cattaraugus County, New York

    USGS Publications Warehouse

    Prudic, David E.

    1979-01-01

    A technique was developed for collecting cores for radiometric analysis from beneath a low-level radioactive-waste landfill to determine the rates of downward radionuclide migration below the trenches. A closed pipe was driven through the buried waste, and a removable point withdrawn. The hole was then advanced by alternately pushing a coring device, then driving an inner casing to the depth reached by the coring device and cleaning out cuttings from within the casing. The effectiveness of the technique was limited by inability to predict the location of impenetrable objects within the waste in some parts of the burial ground and difficulty in detecting when the end of the pipe first penetrated undisturbed material beneath the trench floor. Geophysical logs of the completed hole were used to help determine the trench-floor depth. (USGS).

  13. Direct imaging the upconversion nanocrystal core/shell structure at the subnanometer level: shell thickness dependence in upconverting optical properties.

    PubMed

    Zhang, Fan; Che, Renchao; Li, Xiaomin; Yao, Chi; Yang, Jianping; Shen, Dengke; Hu, Pan; Li, Wei; Zhao, Dongyuan

    2012-06-13

    Lanthanide-doped upconversion nanoparticles have shown considerable promise in solid-state lasers, three-dimensional flat-panel displays, and solar cells and especially biological labeling and imaging. It has been demonstrated extensively that the epitaxial coating of upconversion (UC) core crystals with a lattice-matched shell can passivate the core and enhance the overall upconversion emission intensity of the materials. However, there are few papers that report a precise link between the shell thickness of core/shell nanoparticles and their optical properties. This is mainly because rare earth fluoride upconversion core/shell structures have only been inferred from indirect measurements to date. Herein, a reproducible method to grow a hexagonal NaGdF(4) shell on NaYF(4):Yb,Er nanocrystals with monolayer control thickness is demonstrated for the first time. On the basis of the cryo-transmission electron microscopy, rigorous electron energy loss spectroscopy, and high-angle annular dark-field investigations on the core/shell structure under a low operation temperature (96 K), direct imaging the NaYF(4):Yb,Er@NaGdF(4) nanocrystal core/shell structure at the subnanometer level was realized for the first time. Furthermore, a strong linear link between the NaGdF(4) shell thickness and the optical response of the hexagonal NaYF(4):Yb,Er@NaGdF(4) core/shell nanocrystals has been established. During the epitaxial growth of the NaGdF(4) shell layer by layer, surface defects of the nanocrystals can be gradually passivated by the homogeneous shell deposition process, which results in the obvious enhancement in overall UC emission intensity and lifetime and is more resistant to quenching by water molecules.

  14. Liquid level, void fraction, and superheated steam sensor for nuclear-reactor cores. [PWR; BWR

    DOEpatents

    Tokarz, R.D.

    1981-10-27

    This disclosure relates to an apparatus for monitoring the presence of coolant in liquid or mixed liquid and vapor, and superheated gaseous phases at one or more locations within an operating nuclear reactor core, such as pressurized water reactor or a boiling water reactor.

  15. Microstructure-dependent mechanical properties of electrospun core-shell scaffolds at multi-scale levels.

    PubMed

    Horner, Christopher B; Ico, Gerardo; Johnson, Jed; Zhao, Yi; Nam, Jin

    2016-06-01

    Mechanical factors among many physiochemical properties of scaffolds for stem cell-based tissue engineering significantly affect tissue morphogenesis by controlling stem cell behaviors including proliferation and phenotype-specific differentiation. Core-shell electrospinning provides a unique opportunity to control mechanical properties of scaffolds independent of surface chemistry, rendering a greater freedom to tailor design for specific applications. In this study, we synthesized electrospun core-shell scaffolds having different core composition and/or core-to-shell dimensional ratios. Two independent biocompatible polymer systems, polyetherketoneketone (PEKK) and gelatin as the core materials while maintaining the shell polymer with polycaprolactone (PCL), were utilized. The mechanics of such scaffolds was analyzed at the microscale and macroscales to determine the potential implications it may hold for cell-material and tissue-material interactions. The mechanical properties of individual core-shell fibers were controlled by core-shell composition and structure. The individual fiber modulus correlated with the increase in percent core size ranging from 0.55±0.10GPa to 1.74±0.22GPa and 0.48±0.12GPa to 1.53±0.12GPa for the PEKK-PCL and gelatin-PCL fibers, respectively. More importantly, it was demonstrated that mechanical properties of the scaffolds at the macroscale were dominantly determined by porosity under compression. The increase of scaffold porosity from 70.2%±1.0% to 93.2%±0.5% by increasing the core size in the PEKK-PCL scaffold resulted in the decrease of the compressive elastic modulus from 227.67±20.39kPa to 14.55±1.43kPa while a greater changes in the porosity of gelatin-PCL scaffold from 54.5%±4.2% to 89.6%±0.4% resulted in the compressive elastic modulus change from 484.01±30.18kPa to 17.57±1.40kPa. On the other hand, the biphasic behaviors under tensile mechanical loading result in a range from a minimum of 5.42±1.05MPa to a maximum

  16. Species-level core oral bacteriome identified by 16S rRNA pyrosequencing in a healthy young Arab population

    PubMed Central

    Al-hebshi, Nezar Noor; Abdulhaq, Ahmed; Albarrag, Ahmed; Basode, Vinod Kumar; Chen, Tsute

    2016-01-01

    Background Reports on the composition of oral bacteriome in Arabs are lacking. In addition, the majority of previous studies on other ethnic groups have been limited by low-resolution taxonomic assignment of next-generation sequencing reads. Furthermore, there has been a conflict about the existence of a ‘core’ bacteriome. Objective The objective of this study was to characterize the healthy core oral bacteriome in a young Arab population at the species level. Methods Oral rinse DNA samples obtained from 12 stringently selected healthy young subjects of Arab origin were pyrosequenced (454's FLX chemistry) for the bacterial 16S V1–V3 hypervariable region at an average depth of 11,500 reads. High-quality, non-chimeric reads ≥380 bp were classified to the species level using the recently described, prioritized, multistage assignment algorithm. A core bacteriome was defined as taxa present in at least 11 samples. The Chao2, abundance-based coverage estimator (ACE), and Shannon indices were computed to assess species richness and diversity. Results Overall, 557 species-level taxa (211±42 per subject) were identified, representing 122 genera and 13 phyla. The core bacteriome comprised 55 species-level taxa belonging to 30 genera and 7 phyla, namely Firmicutes, Proteobacteria, Actinobacteria, Bacteroidetes, Fusobacteria, Saccharibacteria, and SR1. The core species constituted between 67 and 87% of the individual bacteriomes. However, the abundances differed by up to three orders of magnitude among the study subjects. On average, Streptococcus mitis, Rothia mucilaginosa, Haemophilus parainfluenzae, Neisseria flavescence/subflava group, Prevotella melaninogenica, and Veillonella parvula group were the most abundant. Streptococcus sp. C300, a taxon never reported in the oral cavity, was identified as a core species. Species richness was estimated at 586 (Chao2) and 614 (ACE) species, whereas diversity (Shannon index) averaged at 3.99. Conclusions A species-level

  17. Levels of metals and semimetals in sedimentary cores in Bertioga Channel, Brazil

    NASA Astrophysics Data System (ADS)

    Sartoretto, J. R.; Salaroli, A.; Figueira, R. C.

    2013-05-01

    The Baixada Santista is one of the most exploited and populated regions of São Paulo state. During the last decades, due to intense industrialization the Baixada Santista has passed through a strong process of environmental degradation. Metals in sediments are persistent, present toxicity in varied concentrations and may be deposited reaching biota habitats. In this context, high concentrations of metals represent environmental concern to costal management. Bertioga Channel is part of this complex system and is known mainly by a wide adjacent mangrove area. The channel is 25 km long, connecting the upstream region of Santos estuary to the adjacent ocean through an inlet located at the city of Bertioga. Urban development generates the concern of potential waste influx from surrounding streams, generating deposits and contaminating surface sediments along the channel, which may lead to adjacent coastal issues. The objective of this study was to characterize the concentration of the following metals at Bertioga Channel sediments: Al, As, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Sc, V and Zn. Five sediment cores were sampled along the channel and analyzed. Determination of metals concentration was based on methods SW 846 US EPA 3050B and EPA 7471. High As concentrations were observed at all cores, with considerable concentration similarity between the first and second sampling points. Analytical results showed that cores Bertioga 4 and Bertioga 5 have accumulated high quantity of metals and semimetals, mainly As, Cd and Cr. Normalization of concentration values showed low contamination at the cores. Nevertheless, As and Hg values indicated moderate to significant contamination at a few sampling points. Despite of the low probability of contamination demonstrated by the normalized values, increasing at the sediment surface of Enrichment Factor (ER), Pollution Load Index (PLI) and Sediment Pollution Index (SPI) parameters were observed. Results indicate that industrialization

  18. The S(2p) Core Level Binding Energies for Alternative Adsorption Sites and the Example of Thiol Self Assembly

    NASA Astrophysics Data System (ADS)

    Jia, Juanjuan; Esaulov, Vladimir; Kara, Abdelkader

    2015-03-01

    Results of an investigation of the characteristics of thiol SAMs obtained by vacuum evaporative adsorption, useful for reactive substrates, are presented along with core level binding energy (BE) calculations. Thiol ended SAMs of 1,4-benzenedimethanethiol (BDMT) are obtained by evaporation on Au. They display an unconventional BE structure at about 161 eV, which is close to a known BE of an S atom on Au. S(2p) core level BE calculations for molecules chemisorbed on hollow, bridge and atop sites are reported and suggest that the 161 eV peak is indeed due to an alternative adsorption site, which can be associated to an atop configuration. This must therefore not be confused with atomic sulfur and dissociation processes with S-C bond scission. Work partially supported by the U.S. Department of Energy Basic Energy Science under Contract No DE-FG02-11ER16243.

  19. An Ultraviolet X-Ray Laser Source for Core Level Spectroscopy and Dynamics of Metal Cluster/Ceramic Chemistry

    DTIC Science & Technology

    2007-11-02

    TYPE AND DATES COVERED Final Rpnnrt. 3/1/97 - 5/31/98 4. TITLE AND SUBTITLE An Ultraviolet X-ray Laser Source for Core Level Spectroscopy and...DISTRIBUTION CODE 13. ABSTRACT (Maximum 200 words) A99B0722 A titanium sapphire ultrafast laser system was procured and merged with a high repetition rate...pulsed valve to produce higher harmonic light output in a rare gas jet. The ultrafast laser system consists of a seed laser , a regenerative amplifier

  20. Ab initio study of 2p core-level x-ray photoemission spectra in ferromagnetic transition metals

    NASA Astrophysics Data System (ADS)

    Takahashi, Manabu; Igarashi, Jun-Ichi

    2012-02-01

    We study the 2p core-level x-ray photoemission spectra in ferromagnetic transition metals, Fe, Co, and Ni using a recently developed ab initio method. The excited final states are set up by distributing electrons on the one-electron states calculated under the fully screened potential in the presence of the core hole. We evaluate the overlap between these excited states and the ground state by using one-electron wave functions, and obtain the spectral curves as a function of binding energy. The calculated spectra reproduce well the observed spectra displaying interesting dependence on the element and on the spin of the removed core electron. The origin of the spectral shapes is elucidated in terms of the one-electron states screening the core hole. The magnetic splitting of the threshold energy is also estimated by using the coherent potential approximation within the fully screened potential approximation. It decreases more rapidly than the local spin moment with moving from Fe to Ni. It is estimated to be almost zero for Ni despite the definite local moment about 0.6μB, in agreement with the experiment.

  1. Core-level spectra and binding energies of transition metal nitrides by non-destructive x-ray photoelectron spectroscopy through capping layers

    NASA Astrophysics Data System (ADS)

    Greczynski, G.; Primetzhofer, D.; Lu, J.; Hultman, L.

    2017-02-01

    We present the first measurements of x-ray photoelectron spectroscopy (XPS) core level binding energies (BE:s) for the widely-applicable group IVb-VIb polycrystalline transition metal nitrides (TMN's) TiN, VN, CrN, ZrN, NbN, MoN, HfN, TaN, and WN as well as AlN and SiN, which are common components in the TMN-based alloy systems. Nitride thin film samples were grown at 400 °C by reactive dc magnetron sputtering from elemental targets in Ar/N2 atmosphere. For XPS measurements, layers are either (i) Ar+ ion-etched to remove surface oxides resulting from the air exposure during sample transfer from the growth chamber into the XPS system, or (ii) in situ capped with a few nm thick Cr or W overlayers in the deposition system prior to air-exposure and loading into the XPS instrument. Film elemental composition and phase content is thoroughly characterized with time-of-flight elastic recoil detection analysis (ToF-E ERDA), Rutherford backscattering spectrometry (RBS), and x-ray diffraction. High energy resolution core level XPS spectra acquired with monochromatic Al Kα radiation on the ISO-calibrated instrument reveal that even mild etching conditions result in the formation of a nitrogen-deficient surface layer that substantially affects the extracted binding energy values. These spectra-modifying effects of Ar+ ion bombardment increase with increasing the metal atom mass due to an increasing nitrogen-to-metal sputter yield ratio. The superior quality of the XPS spectra obtained in a non-destructive way from capped TMN films is evident from that numerous metal peaks, including Ti 2p, V 2p, Zr 3d, and Hf 4f, exhibit pronounced satellite features, in agreement with previously published spectra from layers grown and analyzed in situ. In addition, the N/metal concentration ratios are found to be 25-90% higher than those obtained from the corresponding ion-etched surfaces, and in most cases agree very well with the RBS and ToF-E ERDA values. The N 1 s BE:s extracted from

  2. The electronic characterization of biphenylene—Experimental and theoretical insights from core and valence level spectroscopy

    SciTech Connect

    Lüder, Johann; Sanyal, Biplab; Eriksson, Olle; Brena, Barbara; Puglia, Carla; Simone, Monica de; Totani, Roberta; Coreno, Marcello; Grazioli, Cesare

    2015-02-21

    In this paper, we provide detailed insights into the electronic structure of the gas phase biphenylene molecule through core and valence spectroscopy. By comparing results of X-ray Photoelectron Spectroscopy (XPS) measurements with ΔSCF core-hole calculations in the framework of Density Functional Theory (DFT), we could decompose the characteristic contributions to the total spectra and assign them to non-equivalent carbon atoms. As a difference with similar molecules like biphenyl and naphthalene, an influence of the localized orbitals on the relative XPS shifts was found. The valence spectrum probed by photoelectron spectroscopy at a photon energy of 50 eV in conjunction with hybrid DFT calculations revealed the effects of the localization on the electronic states. Using the transition potential approach to simulate the X-ray absorption spectroscopy measurements, similar contributions from the non-equivalent carbon atoms were determined from the total spectrum, for which the slightly shifted individual components can explain the observed asymmetric features.

  3. N1s and O1s double ionization of the NO and N{sub 2}O molecules

    SciTech Connect

    Hedin, L.; Zhaunerchyk, V.; Karlsson, L.; Pernestål, K.; Feifel, R.; Tashiro, M.; Ehara, M.; Linusson, P.; Eland, J. H. D.; Ueda, K.

    2014-01-28

    Single-site N1s and O1s double core ionisation of the NO and N{sub 2}O molecules has been studied using a magnetic bottle many-electron coincidence time-of-flight spectrometer at photon energies of 1100 eV and 1300 eV. The double core hole energies obtained for NO are 904.8 eV (N1s{sup −2}) and 1179.4 eV (O1s{sup −2}). The corresponding energies obtained for N{sub 2}O are 896.9 eV (terminal N1s{sup −2}), 906.5 eV (central N1s{sup −2}), and 1174.1 eV (O1s{sup −2}). The ratio between the double and single ionisation energies are in all cases close or equal to 2.20. Large chemical shifts are observed in some cases which suggest that reorganisation of the electrons upon the double ionization is significant. Δ-self-consistent field and complete active space self-consistent field (CASSCF) calculations were performed for both molecules and they are in good agreement with these results. Auger spectra of N{sub 2}O, associated with the decay of the terminal and central N1s{sup −2} as well as with the O1s{sup −2} dicationic states, were extracted showing the two electrons emitted as a result of filling the double core holes. The spectra, which are interpreted using CASSCF and complete active space configuration interaction calculations, show atomic-like character. The cross section ratio between double and single core hole creation was estimated as 1.6 × 10{sup −3} for nitrogen at 1100 eV and as 1.3 × 10{sup −3} for oxygen at 1300 eV.

  4. Achievable capacity improvement by using multi-level modulation format in trench-assisted multi-core fiber system.

    PubMed

    Chang, J H; Choi, H G; Chung, Y C

    2013-06-17

    We evaluate the impacts of using multi-level modulation formats on the transmission capacity of the multi-core fiber (MCF) having trench-assisted index profile and hexagonal layout. For this evaluation, we utilize the spectral efficiency per unit area, defined as the spatial spectral efficiency (SSE). The results show that the SSE improvement achievable by using the higher-level modulation format can be reduced due to its lower tolerance to the inter-core crosstalk. We also evaluate the effects of using large effective area on the transmission capacity of the trench-assisted MCF. The results show that the use of large effective area can decrease this capacity due to the increased inter-core crosstalk and lengthened cable cutoff wavelength, although it can help increase the transmission distance. Thus, it is necessary to optimize the effective area of MCF by considering both the SSE and transmission distance. However, the results indicate that the effect of using different effective areas on the SSE-distance product is not significant, and it is not useful to increase the effective area of the trench-assisted MCF to be larger than ~110 μm(2).

  5. Yes we can! Eliminating health disparities as part of the core business of nursing on a global level.

    PubMed

    Villeneuve, Michael J

    2008-11-01

    Nurses in the 21st century are being called to rise to new levels of practice, including a more influential leadership at senior levels of policy development. Decades of research, good will, and a revolutionary civil rights movement have not resolved the world's staggering health outcome disparities. Nursing has a solution: Many of the most troubling disparities are amenable to effective intervention by the world's nurses through their clinical and policy work. The author challenges nurses to imagine the impact on global health if the elimination of disparities is the core goal of nursing for the 21st century. Moving from individuals and communities to systems levels, nurses must be versed in a range of system-level vital signs that affect policy development including economics, demographics, and access to care. Setting our sights on the elimination of health disparities offers a rallying point around which nursing can coalesce and set human health on a new and more equitable course.

  6. The influence of oxygen adsorption on the NEXAFS and core-level XPS spectra of the C{sub 60} derivative PCBM

    SciTech Connect

    Brumboiu, Iulia Emilia Eriksson, Olle; Brena, Barbara; Ericsson, Leif; Hansson, Rickard; Moons, Ellen

    2015-02-07

    Fullerenes have been a main focus of scientific research since their discovery due to the interesting possible applications in various fields like organic photovoltaics (OPVs). In particular, the derivative [6,6]-phenyl-C{sub 60}-butyric acid methyl ester (PCBM) is currently one of the most popular choices due to its higher solubility in organic solvents compared to unsubstituted C{sub 60}. One of the central issues in the field of OPVs is device stability, since modules undergo deterioration (losses in efficiency, open circuit voltage, and short circuit current) during operation. In the case of fullerenes, several possibilities have been proposed, including dimerization, oxidation, and impurity related deterioration. We have studied by means of density functional theory the possibility of oxygen adsorption on the C{sub 60} molecular moiety of PCBM. The aim is to provide guidelines for near edge X-ray absorption fine structure (NEXAFS) and X-ray photoelectron spectroscopy (XPS) measurements which can probe the presence of atomic or molecular oxygen on the fullerene cage. By analysing several configurations of PCBM with one or more adsorbed oxygen atoms, we show that a joint core level XPS and O1s NEXAFS investigation could be effectively used not only to confirm oxygen adsorption but also to pinpoint the bonding configuration and the nature of the adsorbate.

  7. Core-level spectra and molecular deformation in adsorption: V-shaped pentacene on Al(001)

    PubMed Central

    Lin, He; Brivio, Gian Paolo; Floreano, Luca; Fratesi, Guido

    2015-01-01

    Summary By first-principle simulations we study the effects of molecular deformation on the electronic and spectroscopic properties as it occurs for pentacene adsorbed on the most stable site of Al(001). The rationale for the particular V-shaped deformed structure is discussed and understood. The molecule–surface bond is made evident by mapping the charge redistribution. Upon X-ray photoelectron spectroscopy (XPS) from the molecule, the bond with the surface is destabilized by the electron density rearrangement to screen the core hole. This destabilization depends on the ionized carbon atom, inducing a narrowing of the XPS spectrum with respect to the molecules adsorbed hypothetically undistorted, in full agreement to experiments. When looking instead at the near-edge X-ray absorption fine structure (NEXAFS) spectra, individual contributions from the non-equivalent C atoms provide evidence of the molecular orbital filling, hybridization, and interchange induced by distortion. The alteration of the C–C bond lengths due to the V-shaped bending decreases by a factor of two the azimuthal dichroism of NEXAFS spectra, i.e., the energy splitting of the sigma resonances measured along the two in-plane molecular axes. PMID:26734516

  8. [VIEW Level, Special Education Core Curriculum Manual.] I.E.P. Development Guide.

    ERIC Educational Resources Information Center

    Bergen County Region III, Demerest, NJ. Div. of Special Education.

    The Individualized Educational Program development guide is intended for handicapped students at the VIEW level (Vocational Instruction and Experience Workshop). Goals, objectives, and activities are specified for each of seven categories (sample subsections in parentheses): (1) assembly skills (collating, sorting, filing, folding); (2)…

  9. Time-related dynamics of variation in core clock gene expression levels in tissues relevant to the immune system.

    PubMed

    Mazzoccoli, G; Sothern, R B; Greco, A; Pazienza, V; Vinciguerra, M; Liu, S; Cai, Y

    2011-01-01

    Immune parameters show rhythmic changes with a 24-h periodicity driven by an internal circadian timing system that relies on clock genes (CGs). CGs form interlocked transcription-translation feedback loops to generate and maintain 24-h mRNA and protein oscillations. In this study we evaluate and compare the profiles and the dynamics of variation of CG expression in peripheral blood, and two lymphoid tissues of mice. Expression levels of seven recognized key CGs (mBmal1, mClock, mPer1, mPer2, mCry1, mCry2, and Rev-erbalpha) were evaluated by quantitative RT- PCR in spleen, thymus and peripheral blood of C57BL/6 male mice housed on a 12-h light (L)-dark (D) cycle and sacrificed every 4 h for 24 h (3-4 mice/time point). We found a statistically significant time-effect in spleen (S), thymus (T) and blood (B) for the original values of expression level of mBmal1 (S), mClock (T, B), mPer1 (S, B), mPer2 (S), mCry1 (S), mCry2 (B) and mRev-Erbalpha (S, T, B) and for the fractional variation calculated between single time-point expression value of mBmal1 (B), mPer2 (T), mCry2 (B) and mRev-Erbalpha (S). A significant 24-h rhythm was validated for five CGs in blood (mClock, mPer1, mPer2, mCry2, mRev-Erbalpha), for four CGs in the spleen (mBmal1, mPer1, mPer2, mRev-Erbalpha), and for three CGs in the thymus (mClock, mPer2, mRev-Erbalpha). The original values of acrophases for mBmal1, mClock, mPer1, mPer2, mCry1 and mCry2 were very similar for spleen and thymus and advanced by several hours for peripheral blood compared to the lymphoid tissues, whereas the phases of mRev-Erbalpha were coincident for all three tissues. In conclusion, central and peripheral lymphoid tissues in the mouse show different sequences of activation of clock gene expression compared to peripheral blood. These differences may underlie the compartmental pattern of web functioning in the immune system.

  10. Comparison of Roll Stitch Technique and Core Suture Technique for Extensor Tendon Repair at the Metacarpophalangeal Joint level

    PubMed Central

    Namazi, Hamid; Mozaffarian, Kamran; Golmakani, Mohammad Reza

    2016-01-01

    Background: Proper suturing technique is needed to ensure good outcome in extensor tendon surgery. Different techniques have been reported for the repair of extensor tendon injuries at the level of the metacarpophalangeal joint (MCPJ). These reports were in vitro studies on cadaver models. Repair techniques must be clinically tested, to determine results. Objectives: The purpose of this in vivo study was to compare results of extensor tendon repair, using roll stitch and core suture techniques. Patients and Methods: Forty two fingers, in 38 patients (aged 15- 45 years), with simple complete extensor tendon injuries in the MCPJ area, were identified and operated by a single surgeon. The patients were divided into two groups, according to the technique used for tendon repair. The first group consisted of 21 digits, in 19 patients, who were repaired with roll stitch technique, while the second group consisted of 21 digits, in 19 patients, who were repaired with core suture technique. The same splint and rehabilitation regimen (early passive range of motion) were given to all patients. The splints were removed at 6 weeks after surgery and range of motion of the operated fingers was measured and compared to uninjured hands, after 12 weeks. Results: Five patients were lost to follow up or excluded from the study. There was no rupture of the repaired tendons in the groups. There was no statistically significant difference in mean MCPJ flexion, proximal interphalangeal joint (PIPJ) flexion, distal interphalangeal joint (DIPJ) flexion and total range of motion of the fingers, between the two groups. However, extension lag was significantly more common in the second group (11 of 19 digits) compared the first group (four of 17 digits). Conclusions: Roll stitch technique had superior outcome compared to the modified Kessler technique, when performed in the MCPJ area. Level of evidence: Therapeutic (Level III) PMID:27218053

  11. On sulfur core level binding energies in thiol self-assembly and alternative adsorption sites: An experimental and theoretical study

    SciTech Connect

    Jia, Juanjuan; Kara, Abdelkader E-mail: vladimir.esaulov@u-psud.fr; Pasquali, Luca; Bendounan, Azzedine; Sirotti, Fausto; Esaulov, Vladimir A. E-mail: vladimir.esaulov@u-psud.fr

    2015-09-14

    Characteristic core level binding energies (CLBEs) are regularly used to infer the modes of molecular adsorption: orientation, organization, and dissociation processes. Here, we focus on a largely debated situation regarding CLBEs in the case of chalcogen atom bearing molecules. For a thiol, this concerns the case when the CLBE of a thiolate sulfur at an adsorption site can be interpreted alternatively as due to atomic adsorption of a S atom, resulting from dissociation. Results of an investigation of the characteristics of thiol self-assembled monolayers (SAMs) obtained by vacuum evaporative adsorption are presented along with core level binding energy calculations. Thiol ended SAMs of 1,4-benzenedimethanethiol (BDMT) obtained by evaporation on Au display an unconventional CLBE structure at about 161.25 eV, which is close to a known CLBE of a S atom on Au. Adsorption and CLBE calculations for sulfur atoms and BDMT molecules are reported and allow delineating trends as a function of chemisorption on hollow, bridge, and atop sites and including the presence of adatoms. These calculations suggest that the 161.25 eV peak is due to an alternative adsorption site, which could be associated to an atop configuration. Therefore, this may be an alternative interpretation, different from the one involving the adsorption of atomic sulfur resulting from the dissociation process of the S–C bond. Calculated differences in S(2p) CLBEs for free BDMT molecules, SH group sulfur on top of the SAM, and disulfide are also reported to clarify possible errors in assignments.

  12. A Search for Invisible Decays of the Upsilon(1S)

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G. /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-10-17

    We search for invisible decays of the {Upsilon}(1S) meson using a sample of 91.4 x 10{sup 6} {Upsilon}(3S) mesons collected at the BABAR/PEP-II B Factory. We select events containing the decay {Upsilon}(3S) {yields} {pi}{sup +}{pi}{sup -} {Upsilon}(1S) and search for evidence of an undetectable {Upsilon}(1S) decay recoiling against the dipion system. We set an upper limit on the branching fraction {Beta}({Upsilon}(1S) {yields} invisible) < 3.0 x 10{sup ?4} at the 90% confidence level.

  13. Adsorption and dissociation of acidic trace gases on ice surfaces - caught in the act with core level spectroscopy

    NASA Astrophysics Data System (ADS)

    Waldner, Astrid; Orlando, Fabrizio; Ammann, Markus; Kleibert, Armin; Huthwelker, Thomas; Peter, Thomas; Bartels-Rausch, Thorsten

    2015-04-01

    Chemistry and physical processes in Earth's ice and snow cover can change the composition of the atmosphere and the contaminant content of the cryosphere. They have thus direct impacts on geochemical cycles and the climate system. Our ability to predict the fate of chemicals in snow or air masses in exchange with the cryosphere on a regional scale or to model those in snow chemistry models is currently hampered by our limited understanding of the underlying mechanisms on a molecular level. So far, direct experimental observations under environmentally relevant conditions of the ice surface and of the adsorption of trace gases to it are very limited. The unique approach of this study is to combine two surface sensitive spectroscopic methods to directly probe the hydrogen-bonding network at the ice surface ( ~1 nm depth) and the concentration, depth profile (~1 to 10 nm), and dissociation degree of the dopant. We present first core-electron photoemission (XPS) and partial electron yield X-ray absorption (NEXAFS) measurements of formic acid adsorbed to ice at 240 K. The analysis of oxygen NEXAFS spectra reveals information on changes in the hydrogen-bonding network of the ice surface upon adsorption of formic acid. Depth profiles based on XPS measurements indicate that the adsorbed acid stays at the ice surface. Furthermore we obtained a preliminary estimation of the degree of formic acid dissociation at the ice surface. Results are compared to earlier core-electron studies of several trace gases adsorbed to ice at 240 K and compared to results from more traditional method to and snow to reveal fundamental aspects of the ice surface and how it interacts with dopants. Even with the focus on adsorption of acidic trace gases to ice, results of this study will thus be of high relevance also for other chemical processes in ice and snow. This is of interest not only in environmental science but also in material science, cryobiology, and astrophysics.

  14. Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin.

    PubMed

    Dubins, Jeffrey S; Sanchez-Alavez, Manuel; Zhukov, Victor; Sanchez-Gonzalez, Alejandro; Moroncini, Gianluca; Carvajal-Gonzalez, Santos; Hadcock, John R; Bartfai, Tamas; Conti, Bruno

    2012-10-01

    The G protein-coupled receptor 83 (GPR83) was recently demonstrated in warm sensitive neurons (WSN) of the hypothalamic preoptic area (POA) that participate in temperature homeostasis. Thus, we investigated whether GPR83 may have a role in regulating core body temperature (CBT) by reducing its expression in the POA. Dissipation of energy in the form of heat is the primary mode of energy expenditure in mammals and can ultimately affect energy homeostasis. Thus, we also measured the level of important regulators of metabolism. Downregulation of GPR83 was obtained by lentiviral short-hairpin RNAs (shGPR83) vectors designed and selected for their ability to reduce GPR83 levels in vitro. Mice received POA injection of shGPR83 or non-silencing vectors and were monitored for CBT, motor activity, food intake body weight and circulating levels of IGF-1, insulin, leptin and adiponectin. Down-regulation of GPR83 in the POA resulted in a small (0.15°C) but significant reduction of CBT during the dark/active cycle of the day. Temperature reduction was followed by increased body weight gain independent of caloric intake. shGPR83 mice also had increased level of circulating adiponectin (31916±952 pg/mL vs. 23474±1507 pg/mL, P<.01) while no change was observed for insulin, IGF-1 or leptin. GPR83 may participate in central thermoregulation and the central control of circulating adiponectin. Further work is required to determine how GPR83 can affect POA WSN and what are the long term metabolic consequences of its down-regulation.

  15. In-fiber liquid-level probe based on Michelson interferometer via dual-mode elliptical multilayer-core fiber

    NASA Astrophysics Data System (ADS)

    Liang, Xiao; Ren, Guobin; Li, Yang; Liu, Zhibo; Wei, Huai; Jian, Shuisheng

    2016-07-01

    An in-fiber liquid-level probe fabricated from homemade dual-mode elliptical multilayer-core fiber (EMCF) was proposed and experimentally demonstrated. The proposed sensor simply consists of a segment of the EMCF with one end coated with silver film, and a Michelson interferometer is roughly established when light from single-mode fiber incident from the other end. The detected interference patterns, rather clean due to the few-mode property, shift as the liquid level due to strong interaction between high-order modes and measurands through evanescent waves. Both the propagation characteristics and operation principle of such a sensor were demonstrated in detail, and sensitivities of 33.48, 43.35, and 48.93 pm/mm corresponding to liquid indices of 1.333, 1.353, and 1.373 were successfully achieved with a 50-mm EMCF probe, respectively. Moreover, the proposed sensor had the potential to discriminate measurand index after proper calibration.

  16. Core-level attosecond transient absorption spectroscopy of laser-dressed solid films of Si and Zr

    NASA Astrophysics Data System (ADS)

    Seres, Enikoe; Seres, Jozsef; Serrat, Carles; Namba, Shinichi

    2016-10-01

    We investigated experimentally as well as theoretically the ultrafast response of the wave function of the conduction band (CB) of Si and Zr to a near-infrared laser field using extreme ultraviolet (XUV) absorption spectroscopy in the spectral range of 80-220 eV. The measured dynamics of the XUV transmission demonstrates that the wave function of the CB follows the electric field of the dressing laser pulse. In these terms, laser dressing was earlier mainly studied on gases. Measurements with two-femtosecond and 200-attosecond temporal steps were performed in the vicinity of the Si L2 ,3 edge near 100 eV, the Si L1 edge near 150 eV, and the Zr M4 ,5 edge near 180 eV. The observed changes were dependent on the core states being excited by the XUV probe pulse. At the 2 p to CB transitions of Si, the XUV transmission increased via the effect of the dressing laser pulse, while at the 2 s to CB transition of Si and the 3 d to CB transition of Zr, the XUV transmission decreased. Furthermore, beats between the transition from 2 p1 /2 and 2 p3 /2 levels of Si and from 3 d3 /2 and 3 d5 /2 levels of Zr were observed with 20.7 fs and 3.6 fs periods.

  17. A Quantitative Content Analysis of the Common Core State Standards Compared to Missouri's Grade-Level Expectations Using the Revised Bloom's Taxonomy Framework

    ERIC Educational Resources Information Center

    Gallia, Toni

    2012-01-01

    With the pressure in education to develop a 21st century learner with higher-level thinking skills, many educators connected previous state curriculum to the Common Core State Standards (CCSS). Missouri's Department of Education experts paired the previous state's curriculum known as the Missouri Grade Level Expectations (MO GLEs) with a…

  18. Vibrations of acrylonitrile in N 1s excited states

    NASA Astrophysics Data System (ADS)

    Ilakovac, V.; Carniato, S.; Gallet, J.-J.; Kukk, E.; Horvatić, D.; Ilakovac, A.

    2008-01-01

    The N 1s near edge x-ray absorption fine structure spectra of acrylonitrile gas are accurately reproduced by a complete ab initio multidimensional vibrational analysis. The role of π∗ -orbital localization and hybridization on vibrations accompanying core excitation is discussed. Transition to the π⊥∗(C=C-C≡N) delocalized orbital excites mostly stretching vibrations of the whole spinal column of the molecule. Promoting a core electron to the localized π∥∗(C≡N) produces C≡N stretching vibration combined with two strong bending modes of the C-C≡N end of the molecule, related to the change of carbon hybridization.

  19. Core-core and core-valence correlation

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Langhoff, Stephen R.; Taylor, Peter R.

    1988-01-01

    The effect of (1s) core correlation on properties and energy separations was analyzed using full configuration-interaction (FCI) calculations. The Be 1 S - 1 P, the C 3 P - 5 S and CH+ 1 Sigma + or - 1 Pi separations, and CH+ spectroscopic constants, dipole moment and 1 Sigma + - 1 Pi transition dipole moment were studied. The results of the FCI calculations are compared to those obtained using approximate methods. In addition, the generation of atomic natural orbital (ANO) basis sets, as a method for contracting a primitive basis set for both valence and core correlation, is discussed. When both core-core and core-valence correlation are included in the calculation, no suitable truncated CI approach consistently reproduces the FCI, and contraction of the basis set is very difficult. If the (nearly constant) core-core correlation is eliminated, and only the core-valence correlation is included, CASSCF/MRCI approached reproduce the FCI results and basis set contraction is significantly easier.

  20. Core-level Photoemission Study for Cuprates with a Dynamical Mean-Field Approach Considering Realistic Crystal Structure

    NASA Astrophysics Data System (ADS)

    Hariki, Atsushi; Uozumi, Takayuki

    2013-03-01

    Recently, remarkable experimental progress reveals some characteristic spectral features in the 2p3/2main line of Cu 2p core-level X-ray photoemission spectra (XPS). The structures show strong material dependence and drastic changes for electron or hole doping. Van Veenendaal et al., pointed out that the main line shape is strongly affected by the so-called nonlocal screening which is accompanied by a formation of a Zhang-Rice singlet (ZRS) in the XPS final state. On the other hand, Taguchi et al., shows these features are reproduced by introducing an phenomenological extended impurity model. We consider that this topic on 2pXPS of cuprates still remain controversial. In this study, we propose another approach based on the dynamical mean field theory(DMFT) considering the realistic crystal structure. Many-particle effects including the ZRS is appropriately embedded in the hybridization function of a single impurity Anderson model through the DMFT self-consistent cycle. Our approach reproduces experimental results and shows that the Cu 2p3/2 main line is closely related with the quasi-particle structure near the Fermi energy.

  1. Skin-depth lattice strain, core-level trap depression and valence charge polarization of Al surfaces

    NASA Astrophysics Data System (ADS)

    Wang, Yan; Bo, Maolin; Liu, Yonghui; Guo, Yongling; Wang, Haibin; Yue, Jian; Huang, Yongli

    2016-01-01

    Clarifying the origin for surface core-level shift (SCLS) and gaining quantitative information regarding the coordination-resolved local strain, binding energy (BE) shift and cohesive energy change have been a challenge. Here, we show that a combination of the bond order-length-strength (BOLS) premise, X-ray photoelectron spectroscopy (XPS) and the ab initio density functional theory (DFT) calculations of aluminum (Al) 2p3/2 energy shift of Al surfaces has enabled us to derive such information, namely, (i) the 2p3/2 energy of an isolated Al atom (72.146 ± 0.003eV) and its bulk shift (0.499 eV); (ii) the skin lattice contracts by up to 12.5% and the BE density increases by 70%; and (iii) the cohesive energy drops up to 38%. It is affirmed that the shorter and stronger bonds between under-coordinated atoms provide a perturbation to the Hamiltonian and hence lead to the local strain, quantum entrapment and valence charge polarization. Findings should help in understanding the phenomena of surface pre-melting and skin-high elasticity, in general.

  2. Ce Core-Level Spectroscopy, and Magnetic and Electrical Transport Properties of Lightly Ce-Doped YCoO3

    NASA Astrophysics Data System (ADS)

    Kobayashi, Yoshihiko; Koike, Tsuyoshi; Okawa, Mario; Takayanagi, Ryohei; Takei, Shohei; Minohara, Makoto; Kobayashi, Masaki; Horiba, Koji; Kumigashira, Hiroshi; Yasui, Akira; Ikenaga, Eiji; Saitoh, Tomohiko; Asai, Kichizo

    2016-11-01

    We have investigated the Ce and Co core level spectroscopy, and the magnetic and electrical transport properties of lightly Ce-doped YCoO3. We have successfully synthesized single-phase Y1-xCexCoO3 for 0.0 ≤ x ≤ 0.1 by the sol-gel method. Hard X-ray photoelectron and X-ray absorption spectroscopy experiments reveal that the introduced Ce ions are tetravalent, which is considered to be the first case of electron doping into bulk trivalent Co oxides with perovskite RECoO3 (RE: rare-earth element or Y) caused by RE site substitution. The magnitude of the effective magnetic moment peff obtained from the temperature dependence of magnetic susceptibility χ(T) at higher temperatures is close to that for high-spin Co2+ introduced by the Ce doping, implying that the electrons doped into the Co site induce Co2+ with a high-spin state. For x = 0.1, ferromagnetic ordering is observed below about 7 K. Electrical transport properties such as resistivity and thermoelectric power show that negative electron-like carriers are introduced by Ce substitution.

  3. Occupied and unoccupied orbitals of C{sub 60} and C{sub 70} probed with C 1s emission and absorption

    SciTech Connect

    Carlisle, J.A.; Terminello, L.J.; Hudson, E.A.

    1997-04-01

    The aim of this work is to characterize the orbital structure of the fullerenes, and to pursue its evolution from a cluster to the infinite solid. For obtaining a complete picture of the electronic structure the authors compare a variety of experimental techniques, i.e. photoemission and core level emission for occupied orbitals and inverse photoemission and core level absorption for unoccupied orbitals. Their experimental results focus on optical probes involving the C 1s core level, i.e. absorption via transitions from the C 1s level into unoccupied {pi}* and {sigma}* orbitals and emission involving transitions from occupied orbitals into a C 1s hole. Due to the simplicity of the C 1s level there exist clear selection rules. For example, only transitions to and from orbitals with p-character are dipole-allowed. These results on the p-projected density of states are compared with inverse photoemission and photoemission results, where the selection rules are less definitive. In addition, a first-principles quasiparticle calculation of the density of states is used to assign the orbital features. The spectra from C{sub 60} and C{sub 70} are still far from their infinite analog, i.e., graphite, which is also measured with the same techniques. In order to determine the effect of electron transfer onto C{sub 60}, as in superconducting alkali fullerides, the authors are studying resonant emission of C{sub 60}. An electron is placed in the lowest unoccupied molecular orbital (LUMO) by optical absorption from the C 1s level and the C 1s emission detected in the presence of this spectator electron.

  4. In-fiber quasi-Michelson interferometer for liquid level measurement with a core-cladding-modes fiber end-face mirror

    NASA Astrophysics Data System (ADS)

    Rong, Qiangzhou; Qiao, Xueguang; Du, Yanying; Sun, Hao; Feng, Dingyi; Wang, Ruohui; Hu, Manli; Feng, Zhongyao

    2014-06-01

    An in-fiber quasi-Michelson interferometer (IFQMI) working on reflection is proposed and experimentally demonstrated for liquid level measurement. The device consists of a short piece of small-core fiber (SCF) followed by a standard single-mode fiber (SMF) where its end-face is terminated by a thick silver film. A well-defined interference pattern is obtained as the result of the fiber-core mismatch and core-cladding modes interference. The proposed device with a 30 mm pigtail SMF at a wavelength of 1555 nm presents a water level sensitivity of -68.3 pm/mm. Besides, the proposed device can also discriminate the refractive index (RI) of liquid measured. The IFQMI with 50 mm-long SMF provides a high RI sensitivity of -1200.61 (pm/mm)/RIU.

  5. A search at the millijansky level for milli-arcsecond cores in a complete sample of radio galaxies

    NASA Technical Reports Server (NTRS)

    Wehrle, A. E.; Preston, R. A.; Meier, D. L.; Gorenstein, M. V.; Shapiro, I. I.; Rogers, A. E. E.; Rius, A.

    1984-01-01

    A complete sample of 26 extended radio galaxies was observed at 2.29 GHz with the Mark III VLBI system. The fringe spacing was about 3 milli-arcsec, and the detection limit was about 2 millijanskys. Half of the galaxies were found to possess milli-arcsec radio cores. In all but three sources, the nuclear flux density was less than 0.04 of the total flux density. Galaxies with high optical luminosity (less than -21.2) were more likely than less luminous galaxies to contain a detectable milliparcsec radio core (69 percent vs. 20 percent). For objects with arcsec cores, 80 percent were found to have a milli-arcsec core, even though the milli-arcsec object did not always contribute the greater part of the arcsec flux density.

  6. Implications of Multi-Core Architectures on the Development of Multiple Independent Levels of Security (MILS) Compliant Systems

    DTIC Science & Technology

    2012-10-01

    Interconnect Bus on CBEA, QuickPath on Intel and CoreNet on Power PC (PPC)) that facilitate transfer of information between cores. Commercial...framework we re-examined prior work we had conducted on the CBEA processor, and therefore included that work in this report. As a Power PC based processor...we thought the CBEA would have some similarities with the P4080 (another Power - PC based processor) that would be useful in this analysis. We found

  7. Core-level positive-ion and negative-ion fragmentation of gaseous and condensed HCCl3 using synchrotron radiation

    NASA Astrophysics Data System (ADS)

    Lu, K. T.; Chen, J. M.; Lee, J. M.; Haw, S. C.; Liang, Y. C.; Deng, M. J.

    2011-07-01

    We investigated the dissociation dynamics of positive-ion and negative-ion fragments of gaseous and condensed HCCl3 following photoexcitation of Cl 2p electrons to various resonances. Based on ab initio calculations at levels HF/cc-pVTZ and QCISD/6-311G*, the first doublet structures in Cl L-edge x-ray absorption spectrum of HCCl3 are assigned to transitions from the Cl (2P3/2,1/2) initial states to the 10a1* orbitals. The Cl 2p → 10a1* excitation of HCCl3 induces a significant enhancement of the Cl+ desorption yield in the condensed phase and a small increase in the HCCl+ yield in the gaseous phase. Based on the resonant photoemission of condensed HCCl3, excitations of Cl 2p electrons to valence orbitals decay predominantly via spectator Auger transitions. The kinetic energy distributions of Cl+ ion via the Cl 2p → 10a1* excitation are shifted to higher energy ˜0.2 eV and ˜0.1 eV relative to those via the Cl 2p → 10e* excitation and Cl 2p → shape resonance excitation, respectively. The enhancement of the yields of ionic fragments at specific core-excited resonance states is assisted by a strongly repulsive surface that is directly related to the spectator electrons localized in the antibonding orbitals. The Cl- anion is significantly reinforced in the vicinity of Cl 2p ionization threshold of gaseous HCCl3, mediated by photoelectron recapture through post-collision interaction.

  8. Chemical bonding and charge redistribution - Valence band and core level correlations for the Ni/Si, Pd/Si, and Pt/Si systems

    NASA Technical Reports Server (NTRS)

    Grunthaner, P. J.; Grunthaner, F. J.; Madhukar, A.

    1982-01-01

    Via a systematic study of the correlation between the core and valence level X-ray photoemission spectra, the nature of the chemical bonding and charge redistribution for bulk transition metal silicides has been examined. Particular emphasis is placed on Pt2Si and PtSi. It is observed that the strength of the metal (d)-silicon (p) interaction increases in the order Ni2Si, Pd2Si, Pt2Si. It is also observed that both the metal and silicon core lines shift to higher binding energy as the silicides are formed. The notion of charge redistribution for metallic bonds is invoked to explain these data.

  9. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    NASA Astrophysics Data System (ADS)

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  10. An assessment of global and regional sea level for years 1993-2007 in a suite of interannual CORE-II simulations

    NASA Astrophysics Data System (ADS)

    Griffies, Stephen M.; Yin, Jianjun; Durack, Paul J.; Goddard, Paul; Bates, Susan C.; Behrens, Erik; Bentsen, Mats; Bi, Daohua; Biastoch, Arne; Böning, Claus W.; Bozec, Alexandra; Chassignet, Eric; Danabasoglu, Gokhan; Danilov, Sergey; Domingues, Catia M.; Drange, Helge; Farneti, Riccardo; Fernandez, Elodie; Greatbatch, Richard J.; Holland, David M.; Ilicak, Mehmet; Large, William G.; Lorbacher, Katja; Lu, Jianhua; Marsland, Simon J.; Mishra, Akhilesh; George Nurser, A. J.; Salas y Mélia, David; Palter, Jaime B.; Samuels, Bonita L.; Schröter, Jens; Schwarzkopf, Franziska U.; Sidorenko, Dmitry; Treguier, Anne Marie; Tseng, Yu-heng; Tsujino, Hiroyuki; Uotila, Petteri; Valcke, Sophie; Voldoire, Aurore; Wang, Qiang; Winton, Michael; Zhang, Xuebin

    2014-06-01

    We provide an assessment of sea level simulated in a suite of global ocean-sea ice models using the interannual CORE atmospheric state to determine surface ocean boundary buoyancy and momentum fluxes. These CORE-II simulations are compared amongst themselves as well as to observation-based estimates. We focus on the final 15 years of the simulations (1993-2007), as this is a period where the CORE-II atmospheric state is well sampled, and it allows us to compare sea level related fields to both satellite and in situ analyses. The ensemble mean of the CORE-II simulations broadly agree with various global and regional observation-based analyses during this period, though with the global mean thermosteric sea level rise biased low relative to observation-based analyses. The simulations reveal a positive trend in dynamic sea level in the west Pacific and negative trend in the east, with this trend arising from wind shifts and regional changes in upper 700 m ocean heat content. The models also exhibit a thermosteric sea level rise in the subpolar North Atlantic associated with a transition around 1995/1996 of the North Atlantic Oscillation to its negative phase, and the advection of warm subtropical waters into the subpolar gyre. Sea level trends are predominantly associated with steric trends, with thermosteric effects generally far larger than halosteric effects, except in the Arctic and North Atlantic. There is a general anti-correlation between thermosteric and halosteric effects for much of the World Ocean, associated with density compensated changes.

  11. A high-level simulator for the H.264/AVC decoding process in multi-core systems

    NASA Astrophysics Data System (ADS)

    Seitner, Florian H.; Schreier, Ralf M.; Bleyer, Michael; Gelautz, Margrit

    2008-02-01

    ABSTRACT H.264 as a new-generation video coding algorithm is becoming increasingly important for international broadcasting standards such as DVB-H and DMB. In comparison to its predecessors MPEG-2 and MEPG-4 SP/ASP, H.264 achieves improved compression effciency at the cost of increased computational complexity. Real-time execution of the H.264 decoding process poses a large challenge on mobile devices due to low processing capabilities. Multi-core systems provide an elegant and power-effcient solution to overcome this performance limitation. However, effciently distributing the video algorithm among multiple processing units is a non-trivial task. It requires detailed knowledge about the algorithmic complexity, dynamic variations and inter-dependencies between functional blocks. The objective of this paper is an investigation on the dynamic behavior of the H.264 decoding process and on the interaction between the main decoding tasks in the context of multi-core environments. We use an H.264 decoder model to investigate the effciency of a decoding system under various conditions (e.g. different FIFO buffer sizes, bitstreams, coding features and bitrates). The gained insights are finally used to optimize the runtime behavior of a multi-core decoding system and to find a good trade-off between core usage and buffer sizes.

  12. Preservice Secondary Teachers Perceptions of College-Level Mathematics Content Connections with the Common Core State Standards for Mathematics

    ERIC Educational Resources Information Center

    Olson, Travis A.

    2016-01-01

    Preservice Secondary Mathematics Teachers (PSMTs) were surveyed to identify if they could connect early-secondary mathematics content (Grades 7-9) in the Common Core State Standards for Mathematics (CCSSM) with mathematics content studied in content courses for certification in secondary teacher preparation programs. Respondents were asked to…

  13. VLBI-resolution radio-map algorithms: Performance analysis of different levels of data-sharing on multi-socket, multi-core architectures

    NASA Astrophysics Data System (ADS)

    Tabik, S.; Romero, L. F.; Mimica, P.; Plata, O.; Zapata, E. L.

    2012-09-01

    A broad area in astronomy focuses on simulating extragalactic objects based on Very Long Baseline Interferometry (VLBI) radio-maps. Several algorithms in this scope simulate what would be the observed radio-maps if emitted from a predefined extragalactic object. This work analyzes the performance and scaling of this kind of algorithms on multi-socket, multi-core architectures. In particular, we evaluate a sharing approach, a privatizing approach and a hybrid approach on systems with complex memory hierarchy that includes shared Last Level Cache (LLC). In addition, we investigate which manual processes can be systematized and then automated in future works. The experiments show that the data-privatizing model scales efficiently on medium scale multi-socket, multi-core systems (up to 48 cores) while regardless of algorithmic and scheduling optimizations, the sharing approach is unable to reach acceptable scalability on more than one socket. However, the hybrid model with a specific level of data-sharing provides the best scalability over all used multi-socket, multi-core systems.

  14. Early Holocene initiation of the Mekong River delta, Vietnam, and the response to Holocene sea-level changes detected from DT1 core analyses

    NASA Astrophysics Data System (ADS)

    Nguyen, Van Lap; Ta, Thi Kim Oanh; Saito, Yoshiki

    The Early Holocene initiation of the Mekong River delta, Vietnam, was investigated based on sedimentary facies, microfossil analyses, and radiocarbon dating of DT1 core taken from the upper delta plain. The DT1 core (105°38'51″E, 10°17'02″N, elevation + 2 m) is 51.5 m long and located in fill of a buried incised valley. This incised valley of the Paleo-Mekong River formed during the last glacial maximum, which is 20-30 km wide, has been traced spatially from the Cambodian border to the South China Sea coast by compilation of existing core data. The DT1 core records the history of the estuarine channel and delta systems of the Mekong River during the early to middle Holocene. The sedimentary facies, determined particularly from sedimentary structures, diatom and foraminifera assemblages, grain-size variation, and the accumulation rate, clearly show an upward-deepening succession in the lower part of the core from marsh or intertidal flat to subtidal-inner bay facies and an overlying upward-shallowing succession from prodelta to intertidal flat-floodplain. The boundary between the two successions, indicating the maximum flooding surface, occurred at approximately 8.0 ka, at the time that the Mekong River delta was initiated. The delta initiation and sediment facies succession are closely linked to Holocene sea-level changes, particularly a standstill from 8.0 to 7.5 ka after a rapid rise of sea level from 8.8 to 8.2 ka. During the further sea-level rise from 7.5 to 7.0 ka, sediments aggraded, forming topset sedimentary deposits.

  15. Chronic Methamphetamine Self-Administration Dysregulates Oxytocin Plasma Levels and Oxytocin Receptor Fibre Density in the Nucleus Accumbens Core and Subthalamic Nucleus of the Rat.

    PubMed

    Baracz, S J; Parker, L M; Suraev, A S; Everett, N A; Goodchild, A K; McGregor, I S; Cornish, J L

    2016-04-01

    The neuropeptide oxytocin attenuates reward and abuse for the psychostimulant methamphetamine (METH). Recent findings have implicated the nucleus accumbens (NAc) core and subthalamic nucleus (STh) in oxytocin modulation of acute METH reward and relapse to METH-seeking behaviour. Surprisingly, the oxytocin receptor (OTR) is only modestly involved in both regions in oxytocin attenuation of METH-primed reinstatement. Coupled with the limited investigation of the role of the OTR in psychostimulant-induced behaviours, we primarily investigated whether there are cellular changes to the OTR in the NAc core and STh, as well as changes to oxytocin plasma levels, after chronic METH i.v. self-administration (IVSA) and after extinction of drug-taking. An additional aim was to examine whether changes to central corticotrophin-releasing factor (CRF) and plasma corticosterone levels were also apparent because of the interaction of oxytocin with stress-regulatory mechanisms. Male Sprague-Dawley rats were trained to lever press for i.v. METH (0.1 mg/kg/infusion) under a fixed-ratio 1 schedule or received yoked saline infusions during 2-h sessions for 20 days. An additional cohort of rats underwent behavioural extinction for 15 days after METH IVSA. Subsequent to the last day of IVSA or extinction, blood plasma was collected for enzyme immunoassay, and immunofluorescence was conducted on NAc core and STh coronal sections. Rats that self-administered METH had higher oxytocin plasma levels, and decreased OTR-immunoreactive (-IR) fibres in the NAc core than yoked controls. In animals that self-administered METH and underwent extinction, oxytocin plasma levels remained elevated, OTR-IR fibre density increased in the STh, and a trend towards normalisation of OTR-IR fibre density was evident in the NAc core. CRF-IR fibre density in both brain regions and corticosterone plasma levels did not change across treatment groups. These findings demonstrate that oxytocin systems, both centrally

  16. Reconstructing Winter North Pacific Sea-Level Pressure Anomalies Over the Past Three Centuries Using a New Calibration Method with the Eclipse and Mt. Logan Ice Cores

    NASA Astrophysics Data System (ADS)

    Kelsey, E. P.; Wake, C. P.; Osterberg, E. C.

    2012-12-01

    A deeper understanding of the behavior of North Pacific extratropical cyclones and anticyclones prior to the instrumental era is needed to advance our understanding of North Pacific climate variability. To help achieve this objective, we develop and use a new nonlinear ice core calibration procedure with the Eclipse (3017 m a.s.l.) and Mt. Logan (5400 m a.s.l.) ice core records from Yukon, Canada to isolate the ranges of ice core values that are consistently associated with North Pacific wintertime sea-level pressure (SLP) anomalies. Over the calibration period (1872-2001), each ice core record is ranked and divided into 10 groups of 13 years. Then for each group, the frequency of positive and negative SLP anomalies at each grid point is contoured and the composite mean SLP anomaly values are shaded. These plots elucidate areas where statistically significant SLP anomalies occur frequently in association with groups of ice core values. This new calibration procedure shows that the lowest and the two highest groups of Mt. Logan annual [Na+] are sensitive to SLP anomalies in the central and eastern Pacific and the second lowest [Na+] group is sensitive to western Pacific SLP anomalies. The highest and lowest Eclipse cold-season accumulation groups are most sensitive to SLP anomalies more distant in the western and central Pacific. This result is surprising in light of stable isotope studies suggesting a more distant moisture source for Mt. Logan. A reconstruction using these calibrated records indicates the Aleutian Low was predominantly weaker than average between 1699-1871. Our results highlight that having these geographically close ice core records is important to developing a deeper understanding of North Pacific climate variability.

  17. Electronic Charges and Electric Potential at LaAlO3/SrTiO3 Interfaces Studied by Core-Level Photoemission Spectroscopy

    SciTech Connect

    Hwang, Harold

    2011-08-19

    We studied LaAlO{sub 3}/SrTiO{sub 3} interfaces for varying LaAlO{sub 3} thickness by core-level photoemission spectroscopy. In Ti 2p spectra for conducting 'n-type' interfaces, Ti{sup 3+} signals appeared, which were absent for insulating 'p-type' interfaces. The Ti{sup 3+} signals increased with LaAlO{sub 3} thickness, but started well below the critical thickness of 4 unit cells for metallic transport. Core-level shifts with LaAlO{sub 3} thickness were much smaller than predicted by the polar catastrophe model. We attribute these observations to surface defects/adsorbates providing charges to the interface even below the critical thickness.

  18. Spin-Orbit Effects in Spin-Resolved L2,3 Core Level Photoemission of 3d Ferromagnetic Thin Films

    SciTech Connect

    Komesu, T; Waddill, G D; Yu, S W; Butterfield, M; Tobin, J G

    2007-10-02

    We present spin-resolved 2p core level photoemission for the 3d transition metal films of Fe and Co grown on Cu(100). We observe clear spin asymmetry in the main 2p core level photoemission peaks of Fe and Co films consistent with trends in the bulk magnetic moments. The spin polarization can be strongly enhanced, by variation of the experimental geometry, when the photoemission is undertaken with circularly polarized light, indicating that spin-orbit interaction can have a profound in spin polarized photoemission. Further spin polarized photoemission studies using variable circularly polarized light at high photon energies, high flux are indicated, underscoring the value of synchrotron measurements at facilities with increased beam stability.

  19. High-kinetic-energy photoemission spectroscopy of Ni at 1s : 6-eV satellite at 4 eV

    NASA Astrophysics Data System (ADS)

    Karis, O.; Svensson, S.; Rusz, J.; Oppeneer, P. M.; Gorgoi, M.; Schäfers, F.; Braun, W.; Eberhardt, W.; Mårtensson, N.

    2008-12-01

    Electron correlations are responsible for many profound phenomena in solid-state physics. A classical example is the 6-eV satellite in the photoelectron spectrum of Ni. Until now the satellite structure has only been investigated at the L shell and more shallow levels. Here we report a high-kinetic-energy photoemission spectroscopy (HIKE) investigation of Ni metal. We present 1s and 2p photoelectron spectra, obtained using excitation energies up to 12.6 keV. Our investigation demonstrates that the energy position of the satellite relative to the main line is different for the 1s and the 2p levels. In combination with electronic structure calculations, we show that this energy shift is attributed to unique differences in the core-valence coupling for the K and L2,3 shells in 3d transition metals, resulting in different screening of the core holes.

  20. Observation of core-level binding energy shifts between (100) surface and bulk atoms of epitaxial CuInSe{sub 2}

    SciTech Connect

    Nelson, A.J.; Berry, G.; Rockett, A.

    1997-04-01

    Core-level and valence band photoemission from semiconductors has been shown to exhibit binding energy differences between surface atoms and bulk atoms, thus allowing one to unambiguously distinguish between the two atomic positions. Quite clearly, surface atoms experience a potential different from the bulk due to the lower coordination number - a characteristic feature of any surface is the incomplete atomic coordination. Theoretical accounts of this phenomena are well documented in the literature for III-V and II-VI semiconductors. However, surface state energies corresponding to the equilibrium geometry of (100) and (111) surfaces of Cu-based ternary chalcopyrite semiconductors have not been calculated or experimental determined. These compounds are generating great interest for optoelectronic and photovoltaic applications, and are an isoelectronic analog of the II-VI binary compound semiconductors. Surface core-level binding energy shifts depend on the surface cohesive energies, and surface cohesive energies are related to surface structure. For ternary compound semiconductor surfaces, such as CuInSe{sub 2}, one has the possibility of variations in surface stoichiometry. Applying standard thermodynamical calculations which consider the number of individual surface atoms and their respective chemical potentials should allow one to qualitatively determine the magnitude of surface core-level shifts and, consequently, surface state energies.

  1. Clay-mineral assemblages from some levels of K-118 drill core of Maha Sarakham evaporites, northeastern Thailand

    NASA Astrophysics Data System (ADS)

    Suwanich, Parkorn

    Clay-mineral assemblages in Middle Clastic, Middle Salt, Lower Clastic, Potash Zone, and Lower Salt, totalling 13 samples from K-118 drill core, in the Maha Sarakham Formation, Khorat Basin, northeastern Thailand were studied. The clay-size particles were separated from the water-soluble salt by water leaching. Then the samples were leached again in the EDTA solution and separated into clay-size particles by using the timing sedimentation. The EDTA-clay residues were divided and analyzed by using the XRD and XRF method. The XRD peaks show that the major-clay minerals are chlorite, illite, and mixed-layer corrensite including traces of rectorite? and paragonite? The other clay-size particles are quartz and potassium feldspar. The XRF results indicate Mg-rich values and moderate MgAl atom ratio values in those clay minerals. The variable Fe, Na, and K contents in the clay-mineral assemblages can explain the environment of deposition compared to the positions of the samples from the core. Hypothetically, mineralogy and the chemistry of the residual assemblages strongly indicate that severe alteration and Mg-enrichment of normal clay detritus occurred in the evaporite environment through brine-sediment interaction. The various Mg-enrichment varies along the various members reflecting whether sedimentation is near or far from the hypersaline brine.

  2. Global ice volume during MIS 3 inferred from a sea-level analysis of sedimentary core records in the Yellow River Delta

    NASA Astrophysics Data System (ADS)

    Pico, Tamara; Mitrovica, Jerry X.; Ferrier, Ken L.; Braun, Jean

    2016-11-01

    Estimates of global ice volume during the glacial phase of the most recent ice age cycle are characterized by significant uncertainty, reflecting the relative paucity of geological constraints on sea level relevant to this time interval. For example, during the middle stages of Marine Isotope Stage 3, published estimates of peak global mean sea level (GMSL) relative to the present range from -25 m to -87 m. The large uncertainty in GMSL at MIS 3 has significant implications for estimates of the rate of ice growth in the period leading to the Last Glacial Maximum (∼26 ka). We refine estimates of global ice volume during MIS 3 by employing sediment cores in the Bohai and Yellow Sea that record a migration of the paleoshoreline at ∼50-37 ka through a transition from marine to brackish conditions. In particular, we correct relative sea level at these sites for contamination due to glacial isostatic adjustment using a sea-level calculation that includes a gravitationally self-consistent treatment of sediment redistribution and compaction, and estimate a peak global mean sea level of -38 ± 7 m during the interval 50-37 ka. With suitable sedimentary core records, the approach described herein can be extended to refine existing constraints on global ice volume across the entire glacial period.

  3. Synthesis of In2O3@SiO2 core-shell nanoparticles with enhanced deeper energy level emissions of In2O3.

    PubMed

    Fang, Yiping; Loc, Welley S; Lu, Weigang; Fang, Jiye

    2011-12-06

    In(2)O(3)@SiO(2) core-shell nanoparticles were prepared using an organic solution synthesis approach and reverse-microemulsion technique. In order to explore the availability of various silica encapsulations, a partial phase diagram for this ternary system consisting of hexane/cyclohexane (1:29 wt), surfactant (polyoxyethylene(5)nonylphenyl ether, i.e., Igepal CO-520), and aqueous solution containing ammonium hydroxide was also established. It is realized that the shell-thickness can be tuned by several parameters such as the concentration of In(2)O(3) nanocrystal suspension and the dose of the Si-precursor, tetraethyl orthosilicate. It was observed that the deeper energy level emissions of In(2)O(3) were apparently enhanced when In(2)O(3) was confined by the silica-shell in such core-shell nanoparticles. However, this enhancement could be degraded by increasing the shell-thickness.

  4. Suppressed ion chromatography methods for the routine determination of ultra low level anions and cations in ice cores.

    PubMed

    Curran, M A; Palmer, A S

    2001-06-01

    The concentration of trace ionic species in snow and ice samples was determined using suppressed ion chromatography (IC) with conductivity detection and ultra-clean sample preparation techniques. Trace anion species were determined in a single 24-min run by combining sample preconcentration with gradient elution using Na2B4O7 eluent. The detection limits (ranging from 0.001 to 0.006 microM) are the lowest reported in the literature. Cation species were analysed by direct injection of 0.25 ml and isocratic elution with a H2SO4 eluent. The clean preparation techniques showed no evidence of a difference (Student's t-test) between Milli-Q water samples analysed directly and processed Milli-Q ice samples. These robust, ultra-clean IC methods were routinely applied to the analysis of large number of samples to produce a high-resolution trace ion ice core record from Law Dome, East Antarctica.

  5. OptaDOS: A tool for obtaining density of states, core-level and optical spectra from electronic structure codes

    NASA Astrophysics Data System (ADS)

    Morris, Andrew J.; Nicholls, Rebecca J.; Pickard, Chris J.; Yates, Jonathan R.

    2014-05-01

    We present OptaDOS, a program for calculating core-electron and low-loss electron energy loss spectra (EELS) and optical spectra along with total-, projected- and joint-density of electronic states (DOS) from single-particle eigenenergies and dipole transition coefficients. Energy-loss spectroscopy is an important tool for probing bonding within a material. Interpreting these spectra can be aided by first principles calculations. The spectra are generated from the eigenenergies through integration over the Brillouin zone. An important feature of this code is that this integration is performed using a choice of adaptive or linear extrapolation broadening methods which we show produces higher accuracy spectra than standard fixed-width Gaussian broadening. OptaDOS may be straightforwardly interfaced to any electronic structure code. OptaDOS is freely available under the GNU General Public licence from http://www.optados.org.

  6. What is the link between temperature and carbon dioxide levels? A Granger causality analysis based on ice core data

    NASA Astrophysics Data System (ADS)

    Kang, Jian; Larsson, Rolf

    2014-05-01

    We use statistical methods to analyze whether there exists long-term causality between temperature and carbon dioxide concentration. The analysis is based on a the Vostok Ice Core data from 400,000 to 6,000 years ago, extended by the EPICA Dome C data which go back to 800,000 years ago. At first, to make the data equidistant, we reconstruct it by linear interpolation. Then, using an approximation of a piecewise exponential function, we adjust for a deterministic trend. Finally, we employ the Granger causality test. We are able to strongly reject the null hypothesis that carbon dioxide concentration does not Granger cause temperature as well as the reverse hypothesis that temperature does not Granger cause carbon dioxide concentration.

  7. Structural origin of Si-2p core-level shifts from Si(100)-c[4x2] surface: A spectral x-ray photoelectron diffraction study

    SciTech Connect

    Chen, X.; Tonner, B.P.; Denlinger, J.

    1997-04-01

    The authors have performed angle-resolved x-ray photoelectron diffraction (XPD) from a Si(100)-c(4x2) surface to study the structural origin of Si-2p core-level shifts. In the experiment, the highly resolved surface Si-2p core-level spectra were measured as a fine grid of hemisphere and photon energies, using the SpectroMicroscopy Facility {open_quotes}ultraESCA{close_quotes} instrument. By carefully decomposing the spectra into several surface peaks, the authors are able to obtain surface-atom resolved XPD patterns. Using a multiple scattering analysis, they derived a detailed atomic model for the Si(100)-c(4x2) surface. In this model, the asymmetric dimers were found tilted by 11.5 plus/minus 2.0 degrees with bond length of 2.32 plus/minus 0.05{angstrom}. By matching model XPD patterns to experiment, the authors can identify which atoms in the reconstructed surface are responsible for specific photoemission lines in the 2p spectrum.

  8. Holocene lake level changes at a lowland lake in northeastern Germany inferred from acoustic sub-bottom profiling and a transect of sediment cores

    NASA Astrophysics Data System (ADS)

    Dietze, Elisabeth; Zawiska, Izabela; Słowiński, Michał; Brauer, Achim

    2015-04-01

    Holocene lake level changes were studied at Lake Fürstenseer See, a typical lake with complex basin morphology in northeastern German sandur area. An acoustic sub-bottom profile and a transect of four long sediment cores in the deepest lake sub-basin were analyzed. The cores were dated with AMS-14C and correlated with multiple proxies (sediment facies, μ-XRF, macrofossils, subfossil Cladocera, carbonate isotopes). At sites in 10 and 15 m water depth, shifts in the sand-mud boundary, i.e. sediment limit sensu Digerfeldt (1986), allowed quantitative estimates of the absolute amplitude of lake level changes. At sites in 20 and 23 m water depth, the negative correlation of Ca and Ti reflect lake level changes qualitatively. During high lake stands massive organic muds were deposited. Lower lake levels isolated the lake sub-basins which reduced the overall water circulation and lead to the deposition of Ti-poor carbonate muds. Furthermore, macrofossil and subfossil Cladocera analyses were used as proxies for the intense reworking at the slope and for the trophic state of the lake, respectively. Lake levels were up to 4 m higher, e.g. around 5000 cal. yrs BP and during the Medieval time period (see also Kaiser et al., 2014). During the early to mid-Holocene (between 9400 and 6400 cal. yrs BP), Lake Fürstenseer See fluctuated at an at least 3-m lower level. Further water level changes can be related to known climatic events and regional human impact. Digerfeldt, G., 1986. Studies on past lake-level fluctuations. In Berglund, B. (ed.), Handbook of Holocene Palaeoecology and Palaeohydrology: 127-144. John Wiley & Sons, New York. Kaiser, K., Küster, M., Fülling, A., Theuerkauf, M., Dietze, E., Graventein, H., Koch, P.J., Bens, O., Brauer, A., 2014. Littoral landforms and pedosedimentary sequences indicating late Holocene lake-level changes in northern central Europe ' A case study from northeastern Germany. Geomorphology 216, 58-78.

  9. Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population

    SciTech Connect

    Kayaalti, Zeliha; Mergen, Goerkem; Soeylemezoglu, Tuelin

    2010-06-01

    Metallothioneins (MTs) are metal-binding, low molecular weight proteins and are involved in pathophysiological processes like metabolism of essential metals, metal ion homeostasis and detoxification of heavy metals. Metallothionein expression is induced by various heavy metals especially cadmium, mercury and zinc; MTs suppress toxicity of heavy metals by binding themselves to these metals. The aim of this study was to investigate the association between the - 5 A/G metallothionein 2A (MT2A) single nucleotide polymorphism (SNP) and Cd, Zn and Cu levels in the renal cortex from autopsy cases. MT2A core promoter region - 5 A/G SNP was analyzed by PCR-RFLP method using 114 autopsy kidney tissues and the genotype frequencies of this polymorphism were found as 87.7% homozygote typical (AA), 11.4% heterozygote (AG) and 0.9% homozygote atypical (GG). In order to assess the Cd, Zn and Cu levels in the same autopsy kidney tissues, a dual atomic absorption spectrophotometer system was used and the average levels of Cd, Zn and Cu were measured as 95.54 {+-} 65.58 {mu}g/g, 181.20 {+-} 87.72 {mu}g/g and 17.14 {+-} 16.28 {mu}g/g, respectively. As a result, no statistical association was found between the - 5 A/G SNP in the MT2A gene and the Zn and Cu levels in the renal cortex (p > 0.05), but considerably high accumulation of Cd was monitored for individuals having AG (151.24 {+-} 60.21 {mu}g/g) and GG genotypes (153.09 {mu}g/g) compared with individuals having AA genotype (87.72 {+-} 62.98 {mu}g/g) (p < 0.05). These results show that the core promoter region polymorphism of metallothionein 2A increases the accumulation of Cd in human renal cortex.

  10. Preliminary TEX86 temperatures and a lake level record of tropical climate extremes derived from sediment cores and seismic stratigraphy from Lake Turkana, East Africa

    NASA Astrophysics Data System (ADS)

    Morrissey, A. J.; Scholz, C. A.; Russell, J. M.

    2012-12-01

    Lake Turkana is the largest lake in the Eastern Branch of the East African Rift System and records hydrologic conditions of a region spanning nearly 2.5 degrees of latitude (~2.0 - 4.5 degrees N) in the African tropics. New data suggest the Turkana region likely experienced much wetter and cooler climate over several intervals since the latest Pleistocene. Lake level was extremely low twice during the latest Pleistocene, evidenced by depositional hiatuses in high-resolution CHIRP seismic reflection data that correlate with sediments that have low water-content, abundant sand, and low total organic carbon (TOC as low as <0.7%). Lake Turkana, like many lakes in northern tropical Africa, had a wetter climate during the African Humid Period. Intervals of high lake levels (up to ~440 m amsl) are indicated by flat-lying, laterally continuous, low-amplitude reflections that correlate in sediment cores to dark, fine-grained, laminated sediment with high TOC (up to ~6%). Calcium carbonate accumulation during this time period is nearly 0%, and combined with evidence of laminated, unbioturbated sediment suggests a fresh, stratified lake with anoxic bottom waters. During the early mid-Holocene, lake level began to fall to close to present levels (~365 m amsl). Sediments deposited during this time period have low but variable organic carbon content (~0.5 - ~2%) and are much higher in inorganic carbon (from fine-grained calcite precipitation). A moderate lowstand during the late Holocene is indicated by an erosional unconformity seen down to ~40 m below the current lake surface in several seismic profiles. This record of lake level extremes suggests highly variable rainfall patterns, forced by migration of the Intertropical Convergence Zone) across tropical East Africa over the last 20,000 years. More than 50 sediment samples from 3 piston cores represent a continuous record of TEX86 temperature from ~20,000 years ago to modern. The generally low (<0.25) BIT index for the

  11. High-precision frequency measurements: indispensable tools at the core of the molecular-level analysis of complex systems

    PubMed Central

    Ruecker, C.; Meringer, M.; Gugisch, R.; Frommberger, M.; Perdue, E. M.; Witt, M.; Schmitt-Kopplin, P.

    2007-01-01

    This perspective article provides an assessment of the state-of-the-art in the molecular-resolution analysis of complex organic materials. These materials can be divided into biomolecules in complex mixtures (which are amenable to successful separation into unambiguously defined molecular fractions) and complex nonrepetitive materials (which cannot be purified in the conventional sense because they are even more intricate). Molecular-level analyses of these complex systems critically depend on the integrated use of high-performance separation, high-resolution organic structural spectroscopy and mathematical data treatment. At present, only high-precision frequency-derived data exhibit sufficient resolution to overcome the otherwise common and detrimental effects of intrinsic averaging, which deteriorate spectral resolution to the degree of bulk-level rather than molecular-resolution analysis. High-precision frequency measurements are integral to the two most influential organic structural spectroscopic methods for the investigation of complex materials—NMR spectroscopy (which provides unsurpassed detail on close-range molecular order) and FTICR mass spectrometry (which provides unrivalled resolution)—and they can be translated into isotope-specific molecular-resolution data of unprecedented significance and richness. The quality of this standalone de novo molecular-level resolution data is of unparalleled mechanistic relevance and is sufficient to fundamentally advance our understanding of the structures and functions of complex biomolecular mixtures and nonrepetitive complex materials, such as natural organic matter (NOM), aerosols, and soil, plant and microbial extracts, all of which are currently poorly amenable to meaningful target analysis. The discrete analytical volumetric pixel space that is presently available to describe complex systems (defined by NMR, FT mass spectrometry and separation technologies) is in the range of 108–14 voxels, and is

  12. Rapid measurement of perchlorate in polar ice cores down to sub-ng L(-1) levels without pre-concentration.

    PubMed

    Peterson, Kari; Cole-Dai, Jihong; Brandis, Derek; Cox, Thomas; Splett, Scott

    2015-10-01

    An ion chromatography-electrospray ionization-tandem mass spectrometry (IC-ESI-MS/MS) method has been developed for rapid and accurate measurement of perchlorate in polar snow and ice core samples in which perchlorate concentrations are expected to be as low as 0.1 ng L(-1). Separation of perchlorate from major inorganic species in snow is achieved with an ion chromatography system interfaced to an AB SCIEX triple quadrupole mass spectrometer operating in multiple reaction monitoring mode. Under optimized conditions, the limit of detection and lower limit of quantification without pre-concentration have been determined to be 0.1 and 0.3 ng L(-1), respectively, with a linear dynamic range of 0.3-10.0 ng L(-1) in routine measurement. These represent improvements over previously reported methods using similar analytical techniques. The improved method allows fast, accurate, and reproducible perchlorate quantification down to the sub-ng L(-1) level and will facilitate perchlorate measurement in the study of natural perchlorate production with polar ice cores in which perchlorate concentrations are anticipated to vary in the low and sub-ng L(-1) range. Initial measurements of perchlorate in ice core samples from central Greenland show that typical perchlorate concentrations in snow dated prior to the Industrial Revolution are about 0.8 ng L(-1), while perchlorate concentrations are significantly higher in recent (post-1980) snow, suggesting that anthropogenic sources are a significant contributor to perchlorate in the current environment.

  13. Low-level detection and quantification of Plutonium(III, IV, V,and VI) using a liquid core waveguide

    SciTech Connect

    Wilson, Richard E.; Hu, Yung-Jin; Nitsche, Heino

    2003-06-28

    Understanding the aqueous chemistry of plutonium, in particular in environmental conditions, is often complicated by plutonium's complex redox chemistry. Because plutonium possesses four oxidation states, all of which can coexist in solution, a reliable method for the identification of these oxidation states is needed. The identification of plutonium oxidation states at low levels in aqueous solution is often accomplished through an indirect determination using series of liquid-liquid extraction procedures using oxidation state specific reagents such as HDEHP and TTA. While these methods, coupled with radioactive counting techniques provide superior limits of detection they may influence the plutonium redox equilibrium, are time consuming, waste intensive and costly. Other analytical methods such as mass spectrometry and radioactive counting as stand alone methods provide excellent detection limits but lack the ability to discriminate between the oxidation states of the plutonium ions in solution.

  14. The evolution of Ga and As core levels in the formation of Fe/GaAs (001):A high resolution soft x-ray photoelectron spectroscopic study

    SciTech Connect

    Thompson, Jamie; Neal, James; Shen, Tiehan; Morton, Simon; Tobin, James; Waddill, George Dan; Matthew, Jim; Greig, Denis; Hopkinson, Mark

    2008-07-14

    A high resolution soft x-ray photoelectron spectroscopic study of Ga and As 3d core levels has been conducted for Fe/GaAs (001) as a function of Fe thickness. This work has provided unambiguous evidence of substrate disrupting chemical reactions induced by the Fe overlayer--a quantitative analysis of the acquired spectra indicates significantly differing behavior of Ga and As during Fe growth, and our observations have been compared with existing theoretical models. Our results demonstrate that the outdiffusing Ga and As remain largely confined to the interface region, forming a thin intermixed layer. Whereas at low coverages Fe has little influence on the underlying GaAs substrate, the onset of substrate disruption when the Fe thickness reaches 3.5 Angstrom results in major changes in the energy distribution curves (EDCs) of both As and Ga 3d cores. Our quantitative analysis suggests the presence of two additional As environments of metallic character: one bound to the interfacial region and another which, as confirmed by in situ oxidation experiments, surface segregates and persists over a wide range of overlayer thickness. Analysis of the corresponding Ga 3d EDCs found not two, but three additional environments--also metallic in nature. Two of the three are interface resident whereas the third undergoes outdiffusion at low Fe coverages. Based on the variations of the integrated intensities of each component, we present a schematic of the proposed chemical makeup of the Fe/GaAs (001) system.

  15. The evolution of Ga and As core levels in the formation of Fe/GaAs (001): A high resolution soft x-ray photoelectron spectroscopic study

    SciTech Connect

    Thompson, Jamie D. W.; Neal, James R.; Shen, Tiehan H.; Morton, Simon A.; Tobin, James G.; Dan Waddill, G.; Matthew, Jim A. D.; Greig, Denis; Hopkinson, Mark

    2008-07-15

    A high resolution soft x-ray photoelectron spectroscopic study of Ga and As 3d core levels has been conducted for Fe/GaAs (001) as a function of Fe thickness. This work has provided unambiguous evidence of substrate disrupting chemical reactions induced by the Fe overlayer--a quantitative analysis of the acquired spectra indicates significantly differing behavior of Ga and As during Fe growth, and our observations have been compared with existing theoretical models. Our results demonstrate that the outdiffusing Ga and As remain largely confined to the interface region, forming a thin intermixed layer. Whereas at low coverages Fe has little influence on the underlying GaAs substrate, the onset of substrate disruption when the Fe thickness reaches 3.5 A results in major changes in the energy distribution curves (EDCs) of both As and Ga 3d cores. Our quantitative analysis suggests the presence of two additional As environments of metallic character: one bound to the interfacial region and another which, as confirmed by in situ oxidation experiments, surface segregates and persists over a wide range of overlayer thickness. Analysis of the corresponding Ga 3d EDCs found not two, but three additional environments--also metallic in nature. Two of the three are interface resident whereas the third undergoes outdiffusion at low Fe coverages. Based on the variations of the integrated intensities of each component, we present a schematic of the proposed chemical makeup of the Fe/GaAs (001) system.

  16. Warm Core Structure and Mid-Level Intrusion in Hurricane Bonnie (1998) During Landfalling on 26 August 1998

    NASA Technical Reports Server (NTRS)

    Heymsfield, G. M.; Halverson, J.

    2004-01-01

    On 26 August 1998 during CAMEX-3, Hurricane Bonnie was overflown by the NASA ER-2 aircraft instrumented with the EDOP X-Band radar and other instrumentation. Bonnie was an asymmetric storm on this day with several prominent features during its brush with the East coast. One of these features was strong intrusion of dry air on the west side of the storm. During the interaction of this westerly shear with the storm, the precipitation band rotates cyclonically from northwest to the south of the storm center. In this paper, we examine the structure of this dry intrusion and its effect on the storm. The EDOP observations are analyzed along with dropsondes, flight-level observations (NASA DC-8 and NOAA P3), and satellite data. The most apparent feature of the EDOP observations are the strong shears in the interface between the western eyewall updraft, and the dry intrusion. Mammatus are formed along this interface reminiscent of convective rear inflows, and suggestive of intense drying of the air through subsidence. This observation as well as other aspects of the analysis are related to recent numerical simulations of Hurricane Bonnie.

  17. Quantitative Hepatitis B Core Antibody Level Is a New Predictor for Treatment Response In HBeAg-positive Chronic Hepatitis B Patients Receiving Peginterferon

    PubMed Central

    Hou, Feng-Qin; Song, Liu-Wei; Yuan, Quan; Fang, Lin-Lin; Ge, Sheng-Xiang; Zhang, Jun; Sheng, Ji-Fang; Xie, Dong-Ying; Shang, Jia; Wu, Shu-Huan; Sun, Yong-Tao; Wei, Shao-Feng; Wang, Mao-Rong; Wan, Mo-Bin; Jia, Ji-Dong; Luo, Guang-Han; Tang, Hong; Li, Shu-Chen; Niu, Jun-Qi; Zhou, Wei-dong; Sun, Li; Xia, Ning-Shao; Wang, Gui-Qiang

    2015-01-01

    A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positive patients who underwent PEG-IFN therapy for 48 weeks and follow-up for 24 weeks were enrolled in this study. Serum samples were taken every 12 weeks post-treatment. The predictive value of the baseline qAnti-HBc level for treatment response was evaluated. Patients were further divided into 2 groups according to the baseline qAnti-HBc level, and the response rate was compared. Additionally, the kinetics of the virological and biochemical parameters were analyzed. Patients who achieved response had a significantly higher baseline qAnti-HBc level (serological response [SR], 4.52±0.36 vs. 4.19±0.58, p=0.001; virological response [VR], 4.53±0.35 vs. 4.22±0.57, p=0.005; combined response [CR], 4.50±0.36 vs. 4.22±0.58, p=0.009)). Baseline qAnti-HBc was the only parameter that was independently correlated with SR (p=0.008), VR (p=0.010) and CR(p=0.019). Patients with baseline qAnti-HBc levels ≥30,000 IU/mL had significantly higher response rates, more HBV DNA suppression, and better hepatitis control in PEG-IFN treatment. In conclusion, qAnti-HBc level may be a novel biomarker for predicting treatment response in HBeAg-positive patients receiving PEG-IFN therapy. PMID:25553110

  18. Changes in Serum IgA Antibody Levels against the Glycopeptidolipid Core Antigen during Antibiotic Treatment of Mycobacterium avium Complex Lung Disease.

    PubMed

    Jhun, Byung Woo; Kim, Su-Young; Park, Hye Yun; Jeon, Kyeongman; Shin, Sung Jae; Koh, Won-Jung

    2017-03-28

    We evaluated serial changes in the levels of serum immunoglobulin A (IgA) antibody to the glycopeptidolipid (GPL) core antigen during antibiotic treatment in 57 patients with M. avium complex (MAC) lung disease, at baseline (T0) and after 3 months (T3) and 6 months (T6) of treatment. The median patient age was 59 years and 37 (65%) were female. Etiologic organisms included M. avium in 32 (56%) patients and M. intracellulare in 25 (44%). Seven (12%) patients had the fibrocavitary form of the disease on computed tomography. After 12 months of treatment, 42 (74%) patients achieved favorable responses, whereas 15 (26%) patients had unfavorable responses defined as no sputum culture conversion within 12 months of treatment. The initial median serum anti-GPL IgA levels in the 57 patients was 3.50 U/mL, and measurements at T0 (median 3.50 U/mL), T3 (median 2.71 U/mL), and T6 (median 2.61 U/mL) revealed significant decreases following treatment (P < 0.001). Multivariate analysis showed that an initially elevated anti-GPL IgA level (> 3.50 U/mL) was associated with an unfavorable response (P = 0.049). Our data suggest that elevated anti-GPL IgA levels may reflect disease activity, which may help to predict treatment response in patients with MAC lung disease.

  19. The Current Status of the Space Station Biological Research Project: a Core Facility Enabling Multi-Generational Studies under Slectable Gravity Levels

    NASA Astrophysics Data System (ADS)

    Santos, O.

    2002-01-01

    The Space Station Biological Research Project (SSBRP) has developed a new plan which greatly reduces the development costs required to complete the facility. This new plan retains core capabilities while allowing for future growth. The most important piece of equipment required for quality biological research, the 2.5 meter diameter centrifuge capable of accommodating research specimen habitats at simulated gravity levels ranging from microgravity to 2.0 g, is being developed by NASDA, the Japanese space agency, for the SSBRP. This is scheduled for flight to the ISS in 2007. The project is also developing a multi-purpose incubator, an automated cell culture unit, and two microgravity habitat holding racks, currently scheduled for launch in 2005. In addition the Canadian Space Agency is developing for the project an insect habitat, which houses Drosophila melanogaster, and provides an internal centrifuge for 1 g controls. NASDA is also developing for the project a glovebox for the contained manipulation and analysis of biological specimens, scheduled for launch in 2006. This core facility will allow for experimentation on small plants (Arabidopsis species), nematode worms (C. elegans), fruit flies (Drosophila melanogaster), and a variety of microorganisms, bacteria, yeast, and mammalian cells. We propose a plan for early utilization which focuses on surveys of changes in gene expression and protein structure due to the space flight environment. In the future, the project is looking to continue development of a rodent habitat and a plant habitat that can be accommodated on the 2.5 meter centrifuge. By utilizing the early phases of the ISS to broadly answer what changes occur at the genetic and protein level of cells and organisms exposed to the ISS low earth orbit environment, we can generate interest for future experiments when the ISS capabilities allow for direct manipulation and intervention of experiments. The ISS continues to hold promise for high quality, long

  20. An improved flow analysis-ion chromatography method for determination of cationic and anionic species at trace levels in Antarctic ice cores.

    PubMed

    Morganti, Andrea; Becagli, Silvia; Castellano, Emiliano; Severi, Mirko; Traversi, Rita; Udisti, Roberto

    2007-11-12

    A method was developed for the quantitative determination of cations and anions in Antarctic ice cores at microgL(-1) and sub-microgL(-1) levels by ion chromatography (IC), after ultra-clean decontamination procedures. Strict manipulation and decontamination procedures were used in sub-sampling, in order to minimise sample contamination. Na+, NH4+, K+, Mg2+ and Ca2+ were determined by 12-min isocratic elution (H2SO4 eluent). Contemporaneously, in a parallel device, F-, MSA (methanesulfonic acid), Cl-, NO3- and SO4(2-) were analysed in a single 12-min run with multiple-step elution using Na2CO3/NaHCO3 as eluent. Melted ice samples were pumped from their still-closed containers (polystyrene accuvettes with polyethylene caps), shared between the two ion chromatographic systems, online filtered (0.45 microm Teflon membrane) and pre-concentrated (anions and cations pre-concentration columns) using a flow analysis system, thus avoiding uptake of contaminants from the laboratory atmosphere. Sensitivity, linear range, reproducibility and detection limit were evaluated for each chemical species. Anion or cation detection limits ranged from 0.01 to 0.15 microgL(-1) by using a relatively small sample volume (1.5 mL). Such values are significantly lower than those reported in literature for almost all the components. These methods were successfully applied to the analysis of cations and anions at trace levels in the Dome C ice core. The composition of the atmospheric aerosol for the last 850 kyr was reconstructed by high-resolution continuous chemical stratigraphies. Concentration trends in the last nine glacial-interglacial climatic cycles were shown and briefly discussed.

  1. Determination of lead isotopes in a new Greenland deep ice core at the sub-picogram per gram level by thermal ionization mass spectrometry using an improved decontamination method.

    PubMed

    Han, Changhee; Burn-Nunes, Laurie J; Lee, Khanghyun; Chang, Chaewon; Kang, Jung-Ho; Han, Yeongcheol; Hur, Soon Do; Hong, Sungmin

    2015-08-01

    An improved decontamination method and ultraclean analytical procedures have been developed to minimize Pb contamination of processed glacial ice cores and to achieve reliable determination of Pb isotopes in North Greenland Eemian Ice Drilling (NEEM) deep ice core sections with concentrations at the sub-picogram per gram level. A PL-7 (Fuso Chemical) silica-gel activator has replaced the previously used colloidal silica activator produced by Merck and has been shown to provide sufficiently enhanced ion beam intensity for Pb isotope analysis for a few tens of picograms of Pb. Considering the quantities of Pb contained in the NEEM Greenland ice core and a sample weight of 10 g used for the analysis, the blank contribution from the sample treatment was observed to be negligible. The decontamination and analysis of the artificial ice cores and selected NEEM Greenland ice core sections confirmed the cleanliness and effectiveness of the overall analytical process.

  2. Core Concepts of Kinesiology.

    ERIC Educational Resources Information Center

    Hudson, Jackie L.

    1995-01-01

    Core concepts of kinesiology are the basis of communication about movement that facilitate progression of skill levels. The article defines and exemplifies each of 10 core concepts: range of motion, speed of motion, number of segments, nature of segments, balance, coordination, compactness, extension at release/contact, path of projection, and…

  3. More on the Core

    ERIC Educational Resources Information Center

    Chan, Monnica

    2013-01-01

    From a higher education perspective, new "Common Core" standards could improve student college-readiness levels, reduce institutional remediation rates, and close education gaps in and between states. As a national initiative to create common educational standards for students across multiple states, the Common Core State Standards…

  4. Sensitization of depressive-like behavior during repeated maternal separation is associated with more-rapid increase in core body temperature and reduced plasma cortisol levels.

    PubMed

    Yusko, Brittany; Hawk, Kiel; Schiml, Patricia A; Deak, Terrence; Hennessy, Michael B

    2012-02-01

    Infant guinea pigs exhibit a 2-stage response to maternal separation: an initial active stage, characterized by vocalizing, and a second passive stage marked by depressive-like behavior (hunched posture, prolonged eye-closure, extensive piloerection) that appears to be mediated by proinflammatory activity. Recently we found that pups showed an enhanced (i.e., sensitized) depressive-like behavioral response during repeated separation. Further, core body temperature was higher during the beginning of a second separation compared to the first, suggesting a more-rapid stress-induced febrile response to separation the second day, though the possibility that temperature was already elevated prior to the second separation could not be ruled out. Therefore, the present study examined temperature prior to, and during, 2 daily separations. We also examined the temperature response to a third separation conducted 3 days after the second, and assessed the effect of repeated separation on plasma cortisol levels. Core temperature did not differ just prior to the separations, but showed a more-rapid increase and then decline during both a second and third separation than during a first. Temperature responses were not associated with changes in motor activity. Depressive-like behavior was greater during the second and third separations. Pups separated a first time showed a larger plasma cortisol response at the conclusion of separation than did animals of the same age separated a third time. In all, the results indicate that the sensitization of depressive-like behavior during repeated separations over several days is accompanied by a more-rapid febrile response that may be related to a reduction of glucocorticoid suppression.

  5. Intersubband optical absorption between multi energy levels of electrons in InGaN/GaN spherical core-shell quantum dots

    NASA Astrophysics Data System (ADS)

    Liu, W. H.; Qu, Y.; Ban, S. L.

    2017-02-01

    The intersubband optical absorption between multi energy levels of electrons in InxGa1-xN/GaN spherical core-shell quantum dots (CSQDs) and ternary mixed crystal and size effects have been investigated by using the principle of density matrix. Electronic eigenstates under the effect of built-in electric field (BEF) have been calculated by a finite element method. The results show that optical absorption between intersubbands with main quantum numbers n = 1 and n = 2 are as important as that between ones with n = 1 and different angular quantum numbers when the BEF is taken into account. In consideration of BEF, the saturation of total optical absorption coefficients (ACs) and secondary peaks of refractive index changes (RICs) appear when incident light intensity I surpasses a certain value. For a given I, the maximum ACs and zero RICs positions in InxGa1-xN/GaN CSQDs with a fixed shell size have a blue-shift when x increases or the core InxGa1-xN radius R1 decreases from 5 nm. However, when R1 > 5 nm, ACs and RICs tend to be stable. The results indicate that effective adjustment of ACs and RICs in CSQDs with BEFs by size is in a limited scale range. The saturation of ACs or secondary peaks of RICs appear more likely in CSQDs with smaller x or larger R1. These results are expected to be helpful both in the further theoretical and experimental study on optic devices consisting of CSQDs.

  6. Study of Y(3S, 2S)-> eta Y(1S) and Y(3S, 2S) -> pi pi- Y(1S) Hadronic Transitions

    SciTech Connect

    Lees, J.P.; Poireau, V.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Milanes, D.A.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Koch, H.; Schroeder, T.; Asgeirsson, D.J.; Hearty, C.; Mattison, T.S.; McKenna, J.A.; /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /Indian Inst. Tech., Guwahati /Harvard U. /Harvey Mudd Coll. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Paris U., VI-VII /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2012-03-27

    We study the {Upsilon}(3S, 2S) {yields} {eta}{Upsilon}(1S) and {Upsilon}(3S, 2S) {yields} {pi}{sup +}{pi}{sup -}{Upsilon}(1S) transitions with 122 x 10{sup 6} {Upsilon}(3S) and 100 x 10{sup 6} {Upsilon}(2S) mesons collected by the BABAR detector at the PEP-II asymmetric-energy e{sup +}e{sup -} collider. We measure {Beta}[{Upsilon}(2S) {yields} {eta}{Upsilon}(1S)] = (2.39 {+-} 0.31(stat.) {+-} 0.14(syst.)) x 10{sup -4} and {Lambda}[{Upsilon}(2S) {yields} {eta}{Upsilon}(1S)]/{Lambda}[{Upsilon}(2S) {yields} {pi}{sup +}{pi}{sup -}{Upsilon}(1S)] = (1.35 {+-} 0.17(stat.) {+-} 0.08(syst.)) x 10{sup -3}. We find no evidence for {Upsilon}(3S) {yields} {eta}{Upsilon}(1S) and obtain {Beta}[{Upsilon}(3S) {yields} {eta}{Upsilon}(1S)] < 1.0 x 10{sup -4} and {Lambda}[{Upsilon}(3S) {yields} {eta}{Upsilon}(1S)]/{Lambda}[{Upsilon}(3S) {yields} {pi}{sup +}{pi}{sup -}{Upsilon}(1S)] < 2.3 x 10{sup -3} as upper limits at the 90% confidence level. We also provide improved measurements of the {Upsilon}(2S)-{Upsilon}(1S) and {Upsilon}(3S)-{Upsilon}(1S) mass differences, 562.170 {+-} 0.007(stat.) {+-} 0.088(syst.)MeV/c{sup 2} and 893.813 {+-} 0.015(stat.) {+-} 0.107(syst.)MeV/c{sup 2}, respectively.

  7. Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.

    PubMed

    Moy, L Y; Albers, D S; Sonsalla, P K

    1998-04-20

    The neuroprotective effects of lowering body temperature have been well documented in various models of neuronal injury. The present study investigated the effects a lower ambient or core body temperature would have on damage to striatal dopamine (DA) neurons produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice received systemic MPTP treatment at two different temperatures, 4 degrees C and 22 degrees C. MPTP-treated mice maintained at 4 degrees C demonstrated (1) a greater hypothermic response, (2) a significant reduction in striatal DA content and tyrosine hydroxylase (TH) activity, and (3) significantly greater striatal 1-methyl-4-phenylpyridinium (MPP+) levels, as compared to mice dosed with MPTP at room temperature. Parallel studies with methamphetamine (METH) were conducted since temperature appears to play a pivotal role in the mediation of damage to DA neurons by this CNS stimulant in rodents. As previously reported, METH-induced hyperthermia and the subsequent loss of striatal DA content were attenuated in animals dosed at 4 degrees C. We also evaluated the effects a hypothermic state induced by pharmacological agents would have on striatal neurochemistry and MPP+ levels following MPTP treatment. Concurrent administration of MK-801 or 8-OHDPAT increased the striatal MPP+ levels following MPTP treatment. However, only 8-OHDPAT potentiated the MPTP-induced decrements of striatal DA content and TH activity; MK-801 did not affect MPTP decreases in these striatal markers of dopaminergic damage. Altogether, these findings indicate that temperature has a profound effect on striatal MPP+ levels and MPTP-induced damage to DA neurons in mice.

  8. Tretinoin-loaded lipid-core nanocapsules decrease reactive oxygen species levels and improve bovine embryonic development during in vitro oocyte maturation.

    PubMed

    Lucas, Caroline Gomes; Remião, Mariana Härter; Komninou, Eliza Rossi; Domingues, William Borges; Haas, Cristina; Leon, Priscila Marques Moura de; Campos, Vinicius Farias; Ourique, Aline; Guterres, Silvia S; Pohlmann, Adriana R; Basso, Andrea Cristina; Seixas, Fabiana Kömmling; Beck, Ruy Carlos Ruver; Collares, Tiago

    2015-12-01

    In vitro oocyte maturation (IVM) protocols can be improved by adding chemical supplements to the culture media. Tretinoin is considered an important retinoid in embryonic development and its association with lipid-core nanocapsules (TTN-LNC) represents an innovative way of improving its solubility, and chemical stability, and reducing its toxicity. The effects of supplementing IVM medium with TTN-LNC was evaluated by analyzing production of reactive oxygen species (ROS), S36-phosphorilated-p66Shc levels and caspase activity in early embryonic development, and expression of apoptosis and pluripotency genes in blastocysts. The lowest concentration tested (0.25μM) of TTN-LNC generated higher blastocyst rate, lower ROS production and S36-p66Shc amount. Additionally, expression of BAX and SHC1 were lower in both non-encapsulated tretinoin (TTN) and TTN-LNC-treated groups. Nanoencapsulation allowed the use of smaller concentrations of tretinoin to supplement IVM medium thus reducing toxic effects related with its use, decreasing ROS levels and apoptose frequency, and improving the blastocyst rates.

  9. Disentangling Holocene lake level changes with a transect of lake sediment cores - a case study from Lake Fürstenseer See, northeastern Germany

    NASA Astrophysics Data System (ADS)

    Dietze, Elisabeth; Slowinski, Michal; Kienel, Ulrike; Zawiska, Izabela; Brauer, Achim

    2014-05-01

    Deciphering the main processes contributing to lake and landscape evolution in the northern central European lowlands on different temporal scales is one of the main targets of the Virtual Institute of Integrated Climate and Landscape Evolution Analysis (ICLEA) of the Helmholtz Association. In the context of future climatic changes especially the hydrological system is a vulnerable landscape component that showed considerably large changes in the recent past. The analysis of lake sediment archives can help to infer long-term dynamics of regional lake and groundwater levels, although available proxy information needs to be studied carefully, as water level changes are only one trigger. Lake Fürstenseer See (53°19'N, 13°12'E, lake level in 2009: 63.3 m a.s.l.) formed after the retreat of the Weichselian ice sheet in a subglacial channel in the direct forefront of the Pommerian ice margin. The ~2 km2 large lake (zmax = 24.5 m) has a (sub-) surficial catchment area of ~(20) 40 km2 including other smaller lakes and peatlands. In the past, the lake system was artificially dammed for the operation of water mills. Located within the well-drained sandur substrate, the lake levels vary with groundwater levels in response to hydrological and catchment-related groundwater recharge. Detrital matter input from fluvial activity can be excluded. Lake sediment cores at four sites along a transect down to 23 m water depth show distinct sediment facies patterns. Stratigraphic descriptions and non-destructive continuous micro-XRF scanning allowed the differentiation of the main sediment facies, which were microscopically described using thin sections. Quantification of total organic and inorganic matter (TOC, TIC, C/N-composition) and discontinuous macrorest, diatom and Cladocera analysis helped to approach the sedimentation history. Stable isotopes of (delta-180, delta-13C) were used for characterization of carbonates. A high amount of non-reworked terrestrial plant remains from

  10. Millstone-1's senior QC technician

    SciTech Connect

    Taylor, G.M.

    1986-05-01

    Joseph R. Impellizeri, in charge of quality control at the Millstone-1 reactor finds his work requires interpersonal skills as well as technical expertise. The author notes the difference between quality control, which involves the first level of inspection of workmanship and materials for compliance with requirements and the first level review of documents, and quality assurance, which reviews the quality system to see that there are proper procedures and paperwork. Quality control (QC) at Millstone covers inspections, corrective maintenance, and system design changes. Rapport with personnel is essential. Impellizeri must also have level III certification to perform mechanical and electrical installations in order to perform during outages. His activities also include planning for inspections and outages.

  11. Manifestation of screening effects and A-O covalency in the core level spectra of A site elements in the ABO3 structure of Ca1-xSrxRuO3

    NASA Astrophysics Data System (ADS)

    Singh, Ravi Shankar; Maiti, Kalobaran

    2007-08-01

    We investigate the evolution of Ca2p and Sr3d core level spectra in Ca1-xSrxRuO3 using photoemission spectroscopy. Core level spectra in this system exhibit multiple features and unusual evolution with the composition and temperatures. Analysis of the core level spectra in conjunction with the band structure results indicates final state effects due to different core hole screening channels. Such screening in the photoemission final states can be attributed to the large A-O covalency in these systems. Changes in the core level spectra with temperature and composition suggest significant modification in A-O (A=Ca/Sr) covalency in Ca-dominated samples, which gradually reduces with the increase in Sr content and becomes insignificant in SrRuO3 . This study thus provides a direct evidence of cation-oxygen covalency and its evolution with temperature, which may be useful in understanding the unusual ground state properties of these materials.

  12. Information Orientation, Information Technology Governance, and Information Technology Service Management: A Multi-Level Approach for Teaching the MBA Core Information Systems Course

    ERIC Educational Resources Information Center

    Beachboard, John; Aytes, Kregg

    2011-01-01

    Core MBA IT courses have tended to be survey courses that cover important topics but often do not sufficiently engage students. The result is that many top-ranked MBA programs have not found such courses useful enough to include in their core MBA requirements. In this paper, we present a design of an MBA course emphasizing information technology…

  13. Leveling

    USGS Publications Warehouse

    1966-01-01

    Geodetic leveling by the U.S. Geological Survey provides a framework of accurate elevations for topographic mapping. Elevations are referred to the Sea Level Datum of 1929. Lines of leveling may be run either with automatic or with precise spirit levels, by either the center-wire or the three-wire method. For future use, the surveys are monumented with bench marks, using standard metal tablets or other marking devices. The elevations are adjusted by least squares or other suitable method and are published in lists of control.

  14. Facing Challenges for Monte Carlo Analysis of Full PWR Cores : Towards Optimal Detail Level for Coupled Neutronics and Proper Diffusion Data for Nodal Kinetics

    NASA Astrophysics Data System (ADS)

    Nuttin, A.; Capellan, N.; David, S.; Doligez, X.; El Mhari, C.; Méplan, O.

    2014-06-01

    Safety analysis of innovative reactor designs requires three dimensional modeling to ensure a sufficiently realistic description, starting from steady state. Actual Monte Carlo (MC) neutron transport codes are suitable candidates to simulate large complex geometries, with eventual innovative fuel. But if local values such as power densities over small regions are needed, reliable results get more difficult to obtain within an acceptable computation time. In this scope, NEA has proposed a performance test of full PWR core calculations based on Monte Carlo neutron transport, which we have used to define an optimal detail level for convergence of steady state coupled neutronics. Coupling between MCNP for neutronics and the subchannel code COBRA for thermal-hydraulics has been performed using the C++ tool MURE, developed for about ten years at LPSC and IPNO. In parallel with this study and within the same MURE framework, a simplified code of nodal kinetics based on two-group and few-point diffusion equations has been developed and validated on a typical CANDU LOCA. Methods for the computation of necessary diffusion data have been defined and applied to NU (Nat. U) and Th fuel CANDU after assembly evolutions by MURE. Simplicity of CANDU LOCA model has made possible a comparison of these two fuel behaviours during such a transient.

  15. Layer-by-layer resolved core-level shifts in CaF2 and SrF2 on Si(111): Theory and experiment

    NASA Astrophysics Data System (ADS)

    Rotenberg, Eli; Denlinger, J. D.; Leskovar, M.; Hessinger, U.; Olmstead, Marjorie A.

    1994-10-01

    Using x-ray-photoelectron spectroscopy and Auger-electron spectroscopy, we have resolved surface, bulk, and interface Ca and F core-level emission in thin films (3-8 triple layers) of CaF2 and SrF2 on Si(111). We confirmed these assignments using x-ray-photoelectron diffraction (XPD) and surface modification. XPD was also used to identify the growth modes of the films as being either laminar or layer plus islands; in the latter case we have resolved buried and uncovered interface F and Ca/Sr emission. We compare the observed energy differences between surface, bulk, and interface emission to theoretical estimates of the extra-atomic contributions to emission energies. We find excellent agreement considering only the Madelung (electrostatic) potentials for the initial-state contribution and polarization response for the final-state contribution, including the effect of tetragonal strain. Small discrepancies for emission from metal atoms bonded to the Si substrate are interpreted in terms of chemical shifts.

  16. Synthesis Dependent Core Level Binding Energy Shift in the Oxidation State of Platinum Coated on Ceria–Titania and its Effect on Catalytic Decomposition of Methanol

    SciTech Connect

    Karakoti, A. S.; King, Jessica; Vincent, Abhilash; Seal, Sudipta

    2010-11-20

    Synergistic interaction of catalyst and support has attracted the interest of the catalytic community for several decades. The decomposition/oxidation of alcohols for the production of hydrogen as a source of fuel requires such support catalyst interaction. Recent studies have suggested the active role of oxide based supports on the catalytic ability of noble metals such as gold, platinum and palladium. Herein, we report the effect of synthesis technique on the catalytic activity of platinum coated on mixed ceria-titania support system. Wet impregnation technique followed by calcination was compared with the chemical reduction of platinum during the coating over oxide support. Methanol decomposition studied using an in-house built catalytic reactor coupled to a mass spectrometer showed that catalyst prepared by thermal reduction of platinum demonstrated better catalytic ability than the catalyst prepared by chemical reduction of platinum. Transmission electron microscopy revealed that the size of both platinum and ceria-titania particles remained unchanged, while the X-ray photoelectron spectroscopy (XPS) revealed that the oxidation state of platinum was modified by different coating procedures. A shift in the core level binding energy of the Pt 4f towards lower binding energy was observed with chemical reduction. Based on the XPS data it was found that platinum (on ceria-titania supports) in mixed oxidation state outperformed the Pt in reduced metallic state. Results from catalysis and in situ Fourier transform infra red spectroscopy are presented and discussed.

  17. Measurement of the 1s2s 1S0-1s2p 3P1 intercombination interval in helium-like silicon.

    PubMed

    Redshaw, M; Myers, E G

    2002-01-14

    Using Doppler-tuned fast-beam laser spectroscopy the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ has been measured to be 7230.5(2) cm(-1). The experiment made use of a single-frequency Nd:YAG (1.319 microm) laser and a high-finesse optical buildup cavity. The result provides a precision test of modern relativistic and QED atomic theory.

  18. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.

    PubMed

    Borgal, Lori; Rinschen, Markus M; Dafinger, Claudia; Liebrecht, Valérie I; Abken, Hinrich; Benzing, Thomas; Schermer, Bernhard

    2016-01-01

    The PHD zinc finger protein Jade-1S is a component of the HBO1 histone acetyltransferase complex and binds chromatin in a cell cycle-dependent manner. Jade-1S also acts as an E3 ubiquitin ligase for the canonical Wnt effector protein β-catenin and is influenced by CK1α-mediated phosphorylation. To further elucidate the functional impact of this phosphorylation, we used a stable, low-level expression system to express either wild-type or mutant Jade-1S lacking the N-terminal CK1α phosphorylation motif. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1α has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis. Interestingly, cells expressing the mutant displayed an elongated cell shape and a delay in cell cycle progression. Finally, phosphoproteomic analyses allowed identification of a Jade-1S site phosphorylated in the presence of CK1α but closely resembling a PLK1 phosphorylation motif. Our data suggest that Jade-1S phosphorylation at an N-terminal CK1α motif creates a PLK1 phospho-binding domain. We propose CK1α phosphorylation of Jade 1S to serve as a molecular switch, turning off chromatin remodelling functions of Jade-1S and allowing timely cell cycle progression. As Jade-1S protein expression in the kidney is altered upon renal injury, this could contribute to understanding mechanisms underlying epithelial injury repair.

  19. AH-1S communication switch integration program

    NASA Technical Reports Server (NTRS)

    Haworth, Loran; Szoboszlay, Zoltan; Shively, Robert; Bick, Frank J.

    1989-01-01

    The C-6533/ARC communication system as installed on the test AH-1E Cobra helicopter was modified to allow discrete radio selection of all aircraft radios at the cyclic radio/intercommunication system switch. The current Cobra-fleet use of the C-6533 system is cumbersome, particularly during low-altitude operations. Operationally, the current system C-6533 configuration and design requires the pilot to estimate when he can safely remove his hand from an active flight control to select radios during low-altitude flight. The pilot must then physically remove his hand from the flight control, look inside the cockpit to select and verify the radio selection and then effect the selected radio transmission by activating the radio/ICS switch on the cyclic. This condition is potentially hazardous, especially during low-level flight at night in degraded weather. To improve pilot performance, communications effectiveness, and safety, manprint principles were utilized in the selection of a design modification. The modified C-6533 design was kept as basic as possible for potential Cobra-fleet modification. The communications system was modified and the design was subsequently flight-tested by the U.S. Army Aeroflightdynamics Directorate and NASA at the NASA Ames Research Center, Mountain View, California. The design modification enables the Cobra pilot to maintain hands-on flight controls while selecting radios during nap-of-the-Earth (NOE) flight without looking inside the cockpit which resulted in reduced pilot workload ratings, better pilot handling quality ratings and increased flight safety for the NOE flight environment.

  20. Excitation and Ionization in H(1s)-H(1s) Collisions

    SciTech Connect

    Riley, Merle E.; Ritchie, A. Burke

    1999-07-15

    Hydrogen atom - hydrogen atom scattering is a prototype for many of the fundamental principles of atomic collisions. In this work we present an approximation to the H+H system for scattering in the intermediate energy regime of 1 to 100 keV. The approximation ignores electron exchange and two-electron excitation by assuming that one of the atoms is frozen in the 1s state. We allow for the evolution of the active electron by numerically solving the 3D Schroedinger equation. The results capture many features of the problem and are in harmony with recent theoretical studies. Excitation and ionization cross sections are computed and compared to other theory and experiment. New insight into the mechanism of excitation and ionization is inferred from the solutions.

  1. Ligand field splittings in core level transitions for transition metal (TM) oxides: Tanabe-Sugano diagrams and (TM) dangling bonds in vacated O-atom defects

    NASA Astrophysics Data System (ADS)

    Lucovsky, Gerry; Wu, Kun; Pappas, Brian; Whitten, Jerry

    2013-04-01

    Defect states in the forbidden band-gap below the conduction band edge are active as electron traps in nano-grain high-) transition metal (TM) oxides with thickness >0.3 nm, e.g., ZrO2 and HfO2. These oxides have received considerable attention as gate-dielectrics in complementary metal oxide semiconductor (CMOS) devices, and more recently are emerging as candidates for charge storage and memory devices. To provide a theoretical basis for device functionality, ab-initio many-electron theory is combined with X-ray absorption spectroscopy (XAS) to study O K edge and TM core level transitions. These studies identify ligand field splittings (ΔLF) for defect state features,. When compared with those obtained from O-atom and TM-atom core spectroscopic transitions, this provides direct information about defect state sun-nm bonding arrangements. comparisons are made for (i) elemental TiO2 and Ti2O3 with different formal ionic charges, Ti4+ and Ti3+ and for (ii) Magneli Phase alloys, TinO2n-1, n is an integer 9>=n>3, and (TiO2)x(HfO2)1-x alloys. The alloys display multi-valent behavior from (i) different ionic-charge states, (ii} local bond-strain, and (iii) metallic hopping transport. The intrinsic bonding defects in TM oxides are identified as pairs of singly occupied dangling bonds. For 6-fold coordinated Ti-oxides defect excited states in 2nd derivative O K pre-edge spectra are essentially the same as single Ti-atom d2 transitions in Tanabe-Sugano (T-S) diagrams. O-vacated site defects in 8-fold coordinated ZrO2 and HfO2 are described by d8 T-S diagrams. T-S defect state ordering and splittings are functions of the coordination and symmetry of vacated site bordering TM atoms. ΔLF values from the analysis of T-S diagrams indicate medium range order (MRO) extending to 3rd and 4th nearest-neighbor (NN) TM-atoms. Values are different for 6-fold Ti, and 8-fold ZrO2 and HfO2, and scale inversely with differences in respective formal ionic radii. O-vacated site bonding

  2. 24. A CORE WORKER DISPLAYS THE CORE BOX AND CORES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. A CORE WORKER DISPLAYS THE CORE BOX AND CORES FOR A BRASS GATE VALVE BODY MADE ON A CORE BOX, CA. 1950. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  3. Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis.

    PubMed

    Xie, Rui; Wang, Fen; McKeehan, Wallace L; Liu, Leyuan

    2011-12-15

    Dysfunctional autophagy is associated with tumorigenesis; however, the relationship between the two processes remains unclear. In the present study, we showed that MAP1S levels immediately become elevated in response to diethylnitrosamine-induced or genome instability-driven metabolic stress in a murine model of hepatocarcinoma. Upregulation of MAP1S enhanced autophagy to remove aggresomes and dysfunctional organelles that trigger DNA double-strand breaks and genome instability. The early accumulation of an unstable genome before signs of tumorigenesis indicated that genome instability caused tumorigenesis. After tumorigenesis, tumor development triggered the activation of autophagy to reduce genome instability in tumor foci. We, therefore, conclude that an increase in MAP1S levels triggers autophagy to suppress genome instability such that both the incidence of diethylnitrosamine-induced hepatocarcinogenesis and malignant progression are suppressed. Taken together, the data establish a link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis.

  4. RECENT DECLINES IN PAH, PCB, AND TOXAPHENE LEVELS IN THE NORTHERN GREAT LAKES AS DETERMINED FROM HIGH RESOLUTION SEDIMENT CORES. (R825151)

    EPA Science Inventory

    Sediment cores were collected from two sites in Grand Traverse Bay, Lake
    Michigan in May 1998, dated using 210Pb geochronology, and analyzed
    for polychlorinated biphenyl (PCB) congeners, polycyclic aromatic hydrocarbons
    (PAHs), and toxaphene. The extraor...

  5. Search for invisible decays of the {upsilon}(1S) resonance

    SciTech Connect

    Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Selen, M.; White, E. J.; Wiss, J.; Mitchell, R. E.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.; Gao, K. Y.; Hietala, J.; Kubota, Y.; Klein, T.; Lang, B. W.

    2007-02-01

    We present a measurement of the branching fraction of invisible {upsilon}(1S) decays, using 1.2 fb{sup -1} of data collected at the {upsilon}(2S) resonance with the CLEO III detector at CESR. After subtracting expected backgrounds from events that pass selection criteria for invisible {upsilon}(1S) decay in {upsilon}(2S){yields}{pi}{sup +}{pi}{sup -}{upsilon}(1S), we deduce a 90% C.L. upper limit of B[{upsilon}(1S){yields}invisible]<0.39%.

  6. Weak- and hyperfine-interaction-induced 1s2s 1S0 → 1s2 1S0 E1 transition rates of He-like ions

    NASA Astrophysics Data System (ADS)

    Laima, Radžiūtė; Erikas, Gaidamauskas; Gediminas, Gaigalas; Li, Ji-Guang; Dong, Chen-Zhong; Jönsson, Per

    2015-04-01

    Weak- and hyperfine-interaction-induced 1s2s 1S0 → 1s2 1S0 E1 transition rates for the isoelectronic sequence of He-like ions have been calculated using the multi-configuration Dirac-Hartree-Fock (MCDHF) and relativistic configuration interaction methods. The results should be helpful for the future experimental investigations of parity non-conservation effects. Project supported by the National Natural Science Foundation of China (Grant Nos. 11274254, 11147108, 10979007, U1331122, and U1332206) and in part by the National Basic Research Program of China (Grant No. 2013CB922200).

  7. CORE SATURATION BLOCKING OSCILLATOR

    DOEpatents

    Spinrad, R.J.

    1961-10-17

    A blocking oscillator which relies on core saturation regulation to control the output pulse width is described. In this arrangement an external magnetic loop is provided in which a saturable portion forms the core of a feedback transformer used with the thermionic or semi-conductor active element. A first stationary magnetic loop establishes a level of flux through the saturation portion of the loop. A second adjustable magnet moves the flux level to select a saturation point giving the desired output pulse width. (AEC)

  8. Notes on Operations. The Core Record: A New Bibliographic Standard.

    ERIC Educational Resources Information Center

    Cromwell, Willy

    1994-01-01

    Describes a proposed core-level bibliographic standard that combines the cost effectiveness of minimal-level cataloging with full-level cataloging's utility for library cooperation. The process of developing core-level standards, a definition of a core record, comparisons of core records with minimal- and full-level records, and implementation…

  9. Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s.

    PubMed

    Tang, Ling; Peng, Hui; Zhou, Jing; Chen, Yongyan; Wei, Haiming; Sun, Rui; Yokoyama, Wayne M; Tian, Zhigang

    2016-02-01

    Group 1 innate lymphoid cells (ILCs) consist of conventional natural killer (cNK) cells, tissue-resident NK cells and mucosal ILC1s. Recently identified liver-resident NK cells, which can mount contact hypersensitivity responses, and mucosal ILC1s that are involved in pathogenesis of colitis are distinct from cNK cells in several aspects, but the issue of how they are related to each other has not been clearly clarified. Here, we show that liver-resident NK cells and mucosal ILC1s have different phenotypes, as evidenced by distinct expression patterns of homing-associated molecules. Moreover, mucosal ILC1s exhibit tissue residency akin to liver-resident NK cells. Importantly, liver-resident NK cells express relative high levels of cytotoxic effector molecules, which are poorly expressed by mucosal ILC1s, and exhibit stronger cytotoxic activity compared with mucosal ILC1s. These results demonstrate differential phenotypic and functional characteristics of liver-resident NK cells and mucosal ILC1s, shedding new light on the diversity of ILC family.

  10. The excitation energies and term energies of the excited states 1s2ns (n=3,4,5) and 1s2nf (n=4,5) of lithium-like systems of Z=11-20

    NASA Astrophysics Data System (ADS)

    Ge, Zi-Ming; Wang, Zhi-Wen; Zhou, Ya-Jun; He, Li-Ming; Liu, Guo-Guang

    2003-05-01

    In this paper, the full-core plus correlation (FCPC) and the Ritz method is extended to calculate the non-relativistic energies of 1s2ns (n=3,4,5) and 1s2nf (n=4,5) states and the wavefunctions of the lithium-like systems from Z=11-20. The mass-polarization and the relativistic correction including the kinetic-energy correction, the Darwin term, the electron-electron contact term and the orbit-orbit interaction are evaluated perturbatively as the first-order correction. The contribution from quantum electrodynamic is also included by using the effective nuclear charge formula. The excited energies, the term-energy and fine structure, are given and compared with the other theoretical calculation and experimental results. It is shown that the correlative wave in the FCPC method embodies well the strong correlation between the 1s2 core and the valence electron.

  11. Core layering

    NASA Astrophysics Data System (ADS)

    Jacobson, S. A.; Rubie, D. C.; Hernlund, J. W.; Morbidelli, A.

    2015-12-01

    We have created a planetary accretion and differentiation model that self-consistently builds and evolves Earth's core. From this model, we show that the core grows stably stratified as the result of rising metal-silicate equilibration temperatures and pressures, which increases the concentrations of light element impurities into each newer core addition. This stable stratification would naturally resist convection and frustrate the onset of a geodynamo, however, late giant impacts could mechanically mix the distinct accreted core layers creating large homogenous regions. Within these regions, a geodynamo may operate. From this model, we interpret the difference between the planetary magnetic fields of Earth and Venus as a difference in giant impact histories. Our planetary accretion model is a numerical N-body integration of the Grand Tack scenario [1]—the most successful terrestrial planet formation model to date [2,3]. Then, we take the accretion histories of Earth-like and Venus-like planets from this model and post-process the growth of each terrestrial planet according to a well-tested planetary differentiation model [4,5]. This model fits Earth's mantle by modifying the oxygen content of the pre-cursor planetesimals and embryos as well as the conditions of metal-silicate equilibration. Other non-volatile major, minor and trace elements included in the model are assumed to be in CI chondrite proportions. The results from this model across many simulated terrestrial planet growth histories are robust. If the kinetic energy delivered by larger impacts is neglected, the core of each planet grows with a strong stable stratification that would significantly impede convection. However, if giant impact mixing is very efficient or if the impact history delivers large impacts late, than the stable stratification can be removed. [1] Walsh et al. Nature 475 (2011) [2] O'Brien et al. Icarus 223 (2014) [3] Jacobson & Morbidelli PTRSA 372 (2014) [4] Rubie et al. EPSL 301

  12. Effects of molecular potential and geometry on atomic core-level photoemission over an extended energy range - the case study of CO molecule

    NASA Astrophysics Data System (ADS)

    Kukk, E.; Ayuso, D.; Thomas, T. D.; Decleva, P.; Patanen, M.; Argenti, L.; Plésiat, E.; Palacios, A.; Kooser, K.; Travnikova, O.; Mondal, S.; Kimura, M.; Sakai, K.; Miron, C.; Martín, F.; Ueda, K.

    2014-04-01

    We report an experimental and theoretical study of single-molecule inner-shell photoemission over an extended range of photon energies. The vibrational ratios v=1/v=0 from the C 1s photoelectron spectra, although mostly determined by the bond length change, are shown to be affected also by photoelectron recoil and scattering on the neighboring oxygen atom. Density functional theory is used to encompass all these effect in unified treatment. It is also demonstrated that the DFT calculations can be used as a means to extract dynamic and static molecular geometry values.

  13. Mercury's inner core size and core-crystallization regime

    NASA Astrophysics Data System (ADS)

    Dumberry, Mathieu; Rivoldini, Attilio

    2015-03-01

    Earth-based radar observation of Mercury's rotation vector combined with gravity observation by the MESSENGER spacecraft yield a measure of Mercury's moment of inertia and the amplitude of the 88-day libration of its silicate shell. These two geodetic constraints provide information on Mercury's interior structure, including the presence of a fluid core, the radius of the core-mantle boundary and the bulk densities of the core and mantle. In this work, we show how they further provide information on the size of the solid inner core and on the crystallization regime of the fluid core. If Mercury's fluid core is a Fe-FeS alloy with a sulfur concentration on the Fe-rich side of the eutectic, the largest inner core compatible with geodetic observations at the 1σ level is 1325 ± 250 km. Our results further suggest that the crystallization scenario that best fits the geodetic observations involves the formation of Fe-snow within the fluid core, and that this scenario is preferred for models with an iron-poor mantle composition. Consequently, Mercury's dynamo most likely operates in concert with snow formation. For an inner core larger than ∼650 km, snow formation extends to the inner core boundary. If a dynamo cannot be maintained by the dynamics of snow formation, or if such dynamo produces a magnetic field incompatible with observation, Mercury's inner core must then be smaller than 650 km.

  14. Relativistic frozen core potential scheme with relaxation of core electrons

    NASA Astrophysics Data System (ADS)

    Nakajima, Yuya; Seino, Junji; Hayami, Masao; Nakai, Hiromi

    2016-10-01

    This letter proposes a relaxation scheme for core electrons based on the frozen core potential method at the infinite-order Douglas-Kroll-Hess level, called FCP-CR. The core electrons are self-consistently relaxed using frozen molecular valence potentials after the valence SCF calculation is performed. The efficiency of FCP-CR is confirmed by calculations of gold clusters. Furthermore, FCP-CR reproduces the results of the all-electron method for the energies of coinage metal dimers and the core ionization energies and core level shifts of vinyl acetate and three tungsten complexes at the Hartree-Fock and/or symmetry-adapted cluster configuration interaction levels.

  15. Core-level transient absorption spectroscopy as a probe of electron hole relaxation in photoionized H+(H2O)n.

    PubMed

    Li, Zheng; El-Amine Madjet, Mohamed; Vendrell, Oriol; Santra, Robin

    2014-01-01

    There is fundamental interest in understanding the coupled nuclear and electronic dynamics associated with charge transfer processes in complex molecules and materials, which are often mediated by electron, electron hole or proton motion. With dramatic improvements in the techniques to generate extreme ultraviolet (XUV) and X-ray femtosecond pulses, it now becomes possible to trigger and probe these kinds of processes in real time. Here we study the dynamics of an electron hole created by photoionization in the valence shell of protonated water clusters H(+)(H(2)O)(n). We demonstrate that the electron hole is strongly correlated with the protons forming the hydrogen bond network. We show that it is possible to probe key aspects of the valence electron hole dynamics and the coupled nuclear motion with femtosecond time resolution by resonantly exciting K-shell 1s electrons to fill the electron hole. This represents an opportunity for X-ray transient absorption spectroscopy.

  16. Effects of molecular potential and geometry on atomic core-level photoemission over an extended energy range: The case study of the CO molecule

    NASA Astrophysics Data System (ADS)

    Kukk, E.; Ayuso, D.; Thomas, T. D.; Decleva, P.; Patanen, M.; Argenti, L.; Plésiat, E.; Palacios, A.; Kooser, K.; Travnikova, O.; Mondal, S.; Kimura, M.; Sakai, K.; Miron, C.; Martín, F.; Ueda, K.

    2013-09-01

    We report an experimental and theoretical study of single-molecule inner-shell photoemission measured over an extended range of photon energies. The vibrational intensity ratios I(ν=1)/I(ν=0) from the C 1s photoelectron spectra of carbon monoxide, although mostly determined by the bond length change upon ionization, are shown to be affected also by photoelectron recoil and by scattering from the neighboring oxygen atom. Static-exchange density functional theory (DFT) is used to encompass all these effects in a unified theoretical treatment. The ab initio calculations show that the vibrational ratio as a function of the photoelectron momentum is sensitive to both the ground-state internuclear distance and its contraction upon photoionization. We present a proof-of-principle application of DFT calculations as a quantitative structural analysis tool for extracting the dynamic and static molecular geometry parameters simultaneously.

  17. A comparison of methods for calculating O(1S) lifetimes

    NASA Astrophysics Data System (ADS)

    Burns, G. B.; Reid, J. S.

    It is shown theoretically and with simulated data that O(1S) lifetimes determined by the cross-spectral method (Paulson and Shepherd, 1965) are significant overestimates. A comparison is made of the cross-spectral and impulse function analysis (Burns and Reid, 1984) methods using photometric data collected at Macquarie Island (54.5 deg S, 159.0 deg E geographic). The results support the view that the O(1S) state is excited predominantly by an indirect process.

  18. Core Noise Reduction

    NASA Technical Reports Server (NTRS)

    Hultgren, Lennart S.

    2011-01-01

    This presentation is a technical summary of and outlook for NASA-internal and NASA-sponsored external research on core (combustor and turbine) noise funded by the Fundamental Aeronautics Program Subsonic Fixed Wing (SFW) Project. Sections of the presentation cover: the SFW system-level noise metrics for the 2015, 2020, and 2025 timeframes; turbofan design trends and their aeroacoustic implications; the emerging importance of core noise and its relevance to the SFW Reduce-Perceived-Noise Technical Challenge; and the current research activities in the core noise area. Recent work1 on the turbine-transmission loss of combustor noise is briefly described, two2,3 new NRA efforts in the core-noise area are outlined, and an effort to develop CMC-based acoustic liners for broadband noise reduction suitable for turbofan-core application is delineated. The NASA Fundamental Aeronautics Program has the principal objective of overcoming today's national challenges in air transportation. The reduction of aircraft noise is critical to enabling the anticipated large increase in future air traffic. The Subsonic Fixed Wing Project's Reduce-Perceived-Noise Technical Challenge aims to develop concepts and technologies to dramatically reduce the perceived aircraft noise outside of airport boundaries.

  19. Performance and advantages of a soft-core based parallel architecture for energy peak detection in the calorimeter Level 0 trigger for the NA62 experiment at CERN

    NASA Astrophysics Data System (ADS)

    Ammendola, R.; Barbanera, M.; Bizzarri, M.; Bonaiuto, V.; Ceccucci, A.; Checcucci, B.; De Simone, N.; Fantechi, R.; Federici, L.; Fucci, A.; Lupi, M.; Paoluzzi, G.; Papi, A.; Piccini, M.; Ryjov, V.; Salamon, A.; Salina, G.; Sargeni, F.; Venditti, S.

    2017-03-01

    The NA62 experiment at CERN SPS has started its data-taking. Its aim is to measure the branching ratio of the ultra-rare decay K+ → π+ν ν̅ . In this context, rejecting the background is a crucial topic. One of the main background to the measurement is represented by the K+ → π+π0 decay. In the 1-8.5 mrad decay region this background is rejected by the calorimetric trigger processor (Cal-L0). In this work we present the performance of a soft-core based parallel architecture built on FPGAs for the energy peak reconstruction as an alternative to an implementation completely founded on VHDL language.

  20. Mercury levels in sediments of central Mediterranean Sea: a 150+ year record from box-cores recovered in the Strait of Sicily.

    PubMed

    Di Leonardo, Rossella; Tranchida, Giorgio; Bellanca, Adriana; Neri, Rodolfo; Angelone, Massimo; Mazzola, Salvo

    2006-12-01

    To evaluate the degree of anthropogenic mercury pollution, Hg contents have been measured for box-core sediments sampled along three nearshore-offshore transects in the Strait of Sicily and well constrained for their mineralogy, bulk geochemistry and TOC%. Hg values are generally low (from 15 to 70 microg kg(-1)); however, depth profiles clearly display upcore rising concentrations (up to 202 microg kg(-1) near the SE Sicily coast) that are attributed to anthropogenic load. Based on (210)Pb chronology, these trends are more dramatic across the last 20-30 years. Geogenic influence is thought to explain some anomalies related to volcanic emission and geothermal activity. Combined effects due to eastward flowing of the Modified Atlantic Water (MAW) and sea bottom morphology drove major anthropogenic accumulation.

  1. Evidence for the eta_b(1S) in the Decay Upsilon(2S)-> gamma eta_b(1S)

    SciTech Connect

    Aubert, B.; Bona, M.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Lopez, L.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; /LBL, Berkeley /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UCLA /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Karlsruhe U., EKP /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT, LNS /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /Rostock U. /Rutherford /DSM, DAPNIA, Saclay /South Carolina U. /SLAC /Stanford U., Phys. Dept. /SUNY, Albany /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U., IFIC /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-12-14

    We have performed a search for the {eta}{sub b}(1S) meson in the radiative decay of the {Upsilon}(2S) resonance using a sample of 91.6 million {Upsilon}(2S) events recorded with the BABAR detector at the PEP-II B factory at the SLAC National Accelerator Laboratory. We observe a peak in the photon energy spectrum at E{sub {gamma}} = 610.5{sub -4.3}{sup +4.5}(stat) {+-} 1.8(syst) MeV, corresponding to an {eta}{sub b}(1S) mass of 9392.9{sub -4.8}{sup +4.6}(stat) {+-} 1.9(syst) MeV/c{sup 2}. The branching fraction for the decay {Upsilon}(2S) {yields} {gamma}{eta}{sub b}(1S) is determined to be (4.2{sub -1.0}{sup +1.1}(stat) {+-} 0.9(syst)) x 10{sup -4}. The ratio {Beta}({Upsilon}(2S) {yields} {gamma}{eta}{sub b}(1S))/{Beta}({Upsilon}(3S) {yields} {gamma}{eta}{sub b}(1S)) = 0.89{sub -0.23}{sup +0.25}(stat){sub -0.16}{sup +0.12}(syst) is consistent with the ratio expected for magnetic dipole transitions to the {eta}{sub b}(1S) meson.

  2. Core Noise - Increasing Importance

    NASA Technical Reports Server (NTRS)

    Hultgren, Lennart S.

    2011-01-01

    This presentation is a technical summary of and outlook for NASA-internal and NASA-sponsored external research on core (combustor and turbine) noise funded by the Fundamental Aeronautics Program Subsonic Fixed Wing (SFW) Project. Sections of the presentation cover: the SFW system-level noise metrics for the 2015, 2020, and 2025 timeframes; turbofan design trends and their aeroacoustic implications; the emerging importance of core noise and its relevance to the SFW Reduced-Perceived-Noise Technical Challenge; and the current research activities in the core-noise area, with additional details given about the development of a high-fidelity combustor-noise prediction capability as well as activities supporting the development of improved reduced-order, physics-based models for combustor-noise prediction. The need for benchmark data for validation of high-fidelity and modeling work and the value of a potential future diagnostic facility for testing of core-noise-reduction concepts are indicated. The NASA Fundamental Aeronautics Program has the principal objective of overcoming today's national challenges in air transportation. The SFW Reduced-Perceived-Noise Technical Challenge aims to develop concepts and technologies to dramatically reduce the perceived aircraft noise outside of airport boundaries. This reduction of aircraft noise is critical to enabling the anticipated large increase in future air traffic. Noise generated in the jet engine core, by sources such as the compressor, combustor, and turbine, can be a significant contribution to the overall noise signature at low-power conditions, typical of approach flight. At high engine power during takeoff, jet and fan noise have traditionally dominated over core noise. However, current design trends and expected technological advances in engine-cycle design as well as noise-reduction methods are likely to reduce non-core noise even at engine-power points higher than approach. In addition, future low-emission combustor

  3. Calculating core-level excitations and X-ray absorption spectra of medium-sized closed-shell molecules with the algebraic-diagrammatic construction scheme for the polarization propagator.

    PubMed

    Wenzel, Jan; Wormit, Michael; Dreuw, Andreas

    2014-10-05

    Core-level excitations are generated by absorption of high-energy radiation such as X-rays. To describe these energetically high-lying excited states theoretically, we have implemented a variant of the algebraic-diagrammatic construction scheme of second-order ADC(2) by applying the core-valence separation (CVS) approximation to the ADC(2) working equations. Besides excitation energies, the CVS-ADC(2) method also provides access to properties of core-excited states, thereby allowing for the calculation of X-ray absorption spectra. To demonstrate the potential of our implementation of CVS-ADC(2), we have chosen medium-sized molecules as examples that have either biological importance or find application in organic electronics. The calculated results of CVS-ADC(2) are compared with standard TD-DFT/B3LYP values and experimental data. In particular, the extended variant, CVS-ADC(2)-x, provides the most accurate results, and the agreement between the calculated values and experiment is remarkable.

  4. Vibrationally Resolved B 1s Photoionization Cross Section of BF3.

    PubMed

    Ayuso, D; Kimura, M; Kooser, K; Patanen, M; Plésiat, E; Argenti, L; Mondal, S; Travnikova, O; Sakai, K; Palacios, A; Kukk, E; Decleva, P; Ueda, K; Martín, F; Miron, C

    2015-06-11

    Photoelectron diffraction is a well-established technique for structural characterization of solids, based on the interference of the native photoelectron wave with those scattered from the neighboring atoms. For isolated systems in the gas phase similar studies suffer from orders of magnitude lower signals due to the very small sample density. Here we present a detailed study of the vibrationally resolved B 1s photoionization cross section of BF3 molecule. A combination of high-resolution photoelectron spectroscopy measurements and of state-of-the-art static-exchange and time-dependent DFT calculations shows the evolution of the photon energy dependence of the cross section from a complete trapping of the photoelectron wave (low energies) to oscillations due to photoelectron diffraction phenomena. The diffraction pattern allows one to access structural information both for the ground neutral state of the molecule and for the core-ionized cation. Due to a significant change in geometry between the ground and the B 1s(-1) core-ionized state in the BF3 molecule, several vibrational final states of the cation are populated, allowing investigation of eight different relative vibrationally resolved photoionization cross sections. Effects due to recoil induced by the photoelectron emission are also discussed.

  5. Core Journal Lists: Classic Tool, New Relevance

    ERIC Educational Resources Information Center

    Paynter, Robin A.; Jackson, Rose M.; Mullen, Laura Bowering

    2010-01-01

    Reviews the historical context of core journal lists, current uses in collection assessment, and existing methodologies for creating lists. Outlines two next generation core list projects developing new methodologies and integrating novel information/data sources to improve precision: a national-level core psychology list and the other a local…

  6. Estimation of turbulence characteristics of the low-level eyewall and outer-core regions in intense Hurricanes Allen (1980) and Hugo (1989)

    NASA Astrophysics Data System (ADS)

    Zhang, J. A.; Marks, F. D.; Montgomery, M.; Lorsolo, S.

    2010-12-01

    Turbulent transport processes in the atmospheric boundary layer play an important role in the intensification and maintenance of a hurricane vortex. However, direct measurement of turbulence in the hurricane boundary layer has been scarce. This study analyzes the flight-level data collected by research aircraft that penetrated the eyewalls of Category 5 Hurricane Hugo (1989) and Category 4 Hurricane Allen (1980) between 1 km and the sea surface. Momentum flux, turbulent kinetic energy (TKE) and vertical eddy diffusivity are estimated before and during the eyewall penetrations. Spatial scales of turbulent eddies are determined through spectral analysis. The turbulence parameters estimated for the eyewall penetration leg are found to be nearly an order of magnitude larger than those for the leg outside the eyewall at similar altitudes. In the low-level intense eyewall region, the horizontal length scale of dominant turbulent eddies is found to be between 500 - 3000 m and the corresponding vertical length scale is approximately 100 - 200 m. The results suggest also that it is unwise to include the eyewall vorticity maximum (EVM) in the turbulence parameter estimation, since the EVMs are likely to be quasi two-dimensional vortex structures that are embedded within the three dimensional turbulence on the inside edge of the eyewall.

  7. Magic Wavelength for the Hydrogen 1S-2S Transition

    NASA Astrophysics Data System (ADS)

    Kawasaki, Akio

    2016-05-01

    The state of the art precision measurement of the transition frequencies of neutral atoms is performed with atoms trapped by the magic wavelength optical lattice that cancels the ac Stark shift of the transitions. Trapping with magic wavelength lattice is also expected to improve the precision of the hydrogen 1S-2S transition frequency, which so far has been measured only with the atomic beam. In this talk, I discuss the magic wavelength for the hydrogen 1S-2S transition, and the possibility of implementing the optical lattice trapping for hydrogen. Optical trapping of hydrogen also opens the way to perform magnetic field free spectroscopy of antihydrogen for the test of CPT theorem.

  8. Geomagnetism of earth's core

    NASA Technical Reports Server (NTRS)

    Benton, E. R.

    1983-01-01

    Instrumentation, analytical methods, and research goals for understanding the behavior and source of geophysical magnetism are reviewed. Magsat, launched in 1979, collected global magnetometer data and identified the main terrestrial magnetic fields. The data has been treated by representing the curl-free field in terms of a scalar potential which is decomposed into a truncated series of spherical harmonics. Solutions to the Laplace equation then extend the field upward or downward from the measurement level through intervening spaces with no source. Further research is necessary on the interaction between harmonics of various spatial scales. Attempts are also being made to analytically model the main field and its secular variation at the core-mantle boundary. Work is also being done on characterizing the core structure, composition, thermodynamics, energetics, and formation, as well as designing a new Magsat or a tethered satellite to be flown on the Shuttle.

  9. Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients.

    PubMed

    Yan, Chun-Hui; Zhao, Cheng-Yu; Ding, Hai; Peng, Ya-Qin; Jin, Peng-Yuan; Yan, Ling; Zhuang, Hui; Li, Tong

    2012-11-01

    The present study was aimed to obtain baseline information of basal core promoter A1762T/G1764A and precore G1896A mutations of hepatitis B virus (HBV) in 192 HBeAg-positive chronically-infected Chinese patients, who were potential candidates for antiviral treatment. The detection of these mutations (including minor mutant subpopulations) was achieved by direct sequencing, whose sensitivity for minor mutant subpopulations identification was confirmed by clone sequencing. Patients enrolled were infected with either genotype B (46.35%) or C (53.65%) HBV identified by routine tests in our laboratory. The A1762T/G1764A or G1896A mutations were detected in 125specimens (125/192, 65.10%), in which 77 (77/125, 61.60%) existed as subpopulations. The A1762T/G1764A mutations were found to be more prevalent in genotype C than that in genotype B HBV [62.14% (64/103) vs. 20.22% (18/89), P<0.0001]. There is no statistically significant link between G1896A and genotypes. The emergence of A1762T/G1764A mutations was also found to be associated with an older age, an elevated ALT/AST level, and a lower HBsAg level in serum [wild-type vs. mutant: 4.57 (3.46-5.42) vs. 3.93 (2.51-5.36), P<0.0001]. In conclusion, HBV basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients.

  10. Uranium droplet core nuclear rocket

    NASA Technical Reports Server (NTRS)

    Anghaie, Samim

    1991-01-01

    Uranium droplet nuclear rocket is conceptually designed to utilize the broad temperature range ofthe liquid phase of metallic uranium in droplet configuration which maximizes the energy transfer area per unit fuel volume. In a baseline system dissociated hydrogen at 100 bar is heated to 6000 K, providing 2000 second of Isp. Fission fragments and intense radian field enhance the dissociation of molecular hydrogen beyond the equilibrium thermodynamic level. Uranium droplets in the core are confined and separated by an axisymmetric vortex flow generated by high velocity tangential injection of hydrogen in the mid-core regions. Droplet uranium flow to the core is controlled and adjusted by a twin flow nozzle injection system.

  11. The human core of the shared socioeconomic pathways: Population scenarios by age, sex and level of education for all countries to 2100.

    PubMed

    Kc, Samir; Lutz, Wolfgang

    2017-01-01

    This paper applies the methods of multi-dimensional mathematical demography to project national populations based on alternative assumptions on future, fertility, mortality, migration and educational transitions that correspond to the five shared socioeconomic pathways (SSP) storylines. In doing so it goes a significant step beyond past population scenarios in the IPCC context which considered only total population size. By differentiating the human population not only by age and sex-as is conventionally done in demographic projections-but also by different levels of educational attainment the most fundamental aspects of human development and social change are being explicitly addressed through modeling the changing composition of populations by these three important individual characteristics. The scenarios have been defined in a collaborative effort of the international Integrated Assessment Modeling community with the medium scenario following that of a major new effort by the Wittgenstein Centre for Demography and Global Human Capital (IIASA, OEAW, WU) involving over 550 experts from around the world. As a result, in terms of total world population size the trajectories resulting from the five SSPs stay very close to each other until around 2030 and by the middle of the century already a visible differentiation appears with the range between the highest (SSP3) and the lowest (SSP1) trajectories spanning 1.5 billion. The range opens up much more with the SSP3 reaching 12.6 billion in 2100 and SSP1 falling to 6.9 billion which is lower than today's world population.

  12. Novel electrochemical biosensor based on PVP capped CoFe2O4@CdSe core-shell nanoparticles modified electrode for ultra-trace level determination of rifampicin by square wave adsorptive stripping voltammetry.

    PubMed

    Asadpour-Zeynali, Karim; Mollarasouli, Fariba

    2017-06-15

    This work introduces a new electrochemical sensor based on polyvinyl pyrrolidone capped CoFe2O4@CdSe core-shell modified electrode for a rapid detection and highly sensitive determination of rifampicin (RIF) by square wave adsorptive stripping voltammetry. The new PVP capped CoFe2O4@CdSe with core-shell nanostructure was synthesized by a facile synthesis method for the first time. PVP can act as a capping and etching agent for protection of the outer surface nanoparticles and formation of a mesoporous shell, respectively. Another important feature of this work is the choice of the ligand (1,10-phenanthroline) for precursor cadmium complex that works as a chelating agent in order to increase optical and electrical properties and stability of prepared nanomaterial. The nanoparticles have been characterized by field emission scanning electron microscopy (FESEM), transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), UV-vis, photoluminescence (PL) spectroscopy, FT-IR, and cyclic voltammetry techniques. The PL spectroscopy study of CoFe2O4@CdSe has shown significant PL quenching by the formation of CoFe2O4 core inside CdSe, this shows that CoFe2O4 NPs are efficient electron acceptors with the CdSe. It is clearly observed that the biosensor can significantly enhance electrocatalytic activity towards the oxidation of RIF, under the optimal conditions. The novelty of this work arises from the new synthesis method for the core-shell of CoFe2O4@CdSe. Then, the novel electrochemical biosensor was fabricated for ultra-trace level determination of rifampicin with very low detection limit (4.55×10(-17)M) and a wide linear range from 1.0×10(-16) to 1.0×10(-7)M. The fabricated biosensor showed high sensitivity and selectivity, good reproducibility and stability. Therefore, it was successfully applied for the determination of ultra-trace RIF amounts in biological and pharmaceutical samples with satisfactory recovery data.

  13. A Dynamical Framework for the All-or-None G1/S Transition

    PubMed Central

    Barr, Alexis R.; Heldt, Frank S.; Zhang, Tongli; Bakal, Chris; Novák, Béla

    2016-01-01

    Summary The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk inhibitors (CKIs), and the anaphase-promoting complex/cyclosome (APC/C). Understanding the cellular decision to commit to S phase requires a quantitative description of these interactions. We apply quantitative imaging of single human cells to track the expression of G1/S regulators and use these data to parametrize a stochastic mathematical model of the G1/S transition. We show that a rapid, proteolytic, double-negative feedback loop between Cdk2:Cyclin and the Cdk inhibitor p27Kip1 drives a switch-like entry into S phase. Furthermore, our model predicts that increasing Emi1 levels throughout S phase are critical in maintaining irreversibility of the G1/S transition, which we validate using Emi1 knockdown and live imaging of G1/S reporters. This work provides insight into the general design principles of the signaling networks governing the temporally abrupt transitions between cell-cycle phases. PMID:27136687

  14. Search for the 0- glueball in ϒ (1 S ) and ϒ (2 S ) decays

    NASA Astrophysics Data System (ADS)

    Jia, S.; Shen, C. P.; Yuan, C. Z.; Adachi, I.; Aihara, H.; Al Said, S.; Asner, D. M.; Aushev, T.; Ayad, R.; Babu, V.; Badhrees, I.; Bakich, A. M.; Bansal, V.; Barberio, E.; Behera, P.; Bhuyan, B.; Biswal, J.; Bonvicini, G.; Bozek, A.; Bračko, M.; Browder, T. E.; Červenkov, D.; Chang, P.; Chekelian, V.; Chen, A.; Cheon, B. G.; Chilikin, K.; Cho, K.; Choi, S.-K.; Choi, Y.; Cinabro, D.; Dash, N.; Di Carlo, S.; Doležal, Z.; Drásal, Z.; Dutta, D.; Eidelman, S.; Farhat, H.; Fast, J. E.; Ferber, T.; Fulsom, B. G.; Gaur, V.; Gabyshev, N.; Garmash, A.; Gillard, R.; Goldenzweig, P.; Golob, B.; Haba, J.; Hara, T.; Hayasaka, K.; Hayashii, H.; Hedges, M. T.; Hou, W.-S.; Iijima, T.; Inami, K.; Inguglia, G.; Ishikawa, A.; Itoh, R.; Jaegle, I.; Joffe, D.; Joo, K. K.; Julius, T.; Kang, K. H.; Katrenko, P.; Kawasaki, T.; Kichimi, H.; Kiesling, C.; Kim, D. Y.; Kim, H. J.; Kim, J. B.; Kim, K. T.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kodyš, P.; Korpar, S.; Kotchetkov, D.; Križan, P.; Krokovny, P.; Kuhr, T.; Kulasiri, R.; Kuzmin, A.; Kwon, Y.-J.; Lange, J. S.; Li, C. H.; Li, L.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, D.; Lubej, M.; Luo, T.; Masuda, M.; Matsuda, T.; Matvienko, D.; Miyabayashi, K.; Miyata, H.; Mizuk, R.; Moon, H. K.; Mori, T.; Nakao, M.; Nanut, T.; Nath, K. J.; Natkaniec, Z.; Nayak, M.; Niiyama, M.; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Ono, H.; Onuki, Y.; Ostrowicz, W.; Pakhlova, G.; Pal, B.; Park, C.-S.; Park, H.; Pestotnik, R.; Piilonen, L. E.; Pulvermacher, C.; Ritter, M.; Rostomyan, A.; Sakai, Y.; Sandilya, S.; Santelj, L.; Sanuki, T.; Savinov, V.; Schneider, O.; Schnell, G.; Schwanda, C.; Seino, Y.; Senyo, K.; Sevior, M. E.; Shebalin, V.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Simon, F.; Sokolov, A.; Solovieva, E.; Starič, M.; Strube, J. F.; Sumihama, M.; Sumiyoshi, T.; Suzuki, K.; Takizawa, M.; Tamponi, U.; Tanida, K.; Tenchini, F.; Uchida, M.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Usov, Y.; Van Hulse, C.; Varner, G.; Vorobyev, V.; Wang, C. H.; Wang, M.-Z.; Wang, P.; Watanabe, Y.; Widmann, E.; Won, E.; Yamashita, Y.; Ye, H.; Yelton, J.; Zhang, Z. P.; Zhilich, V.; Zhukova, V.; Zhulanov, V.; Zupanc, A.; Belle Collaboration

    2017-01-01

    We report the first search for the JP C=0- glueball in ϒ (1 S ) and ϒ (2 S ) decays with data samples of (102 ±2 )×1 06 and (158 ±4 )×1 06 events, respectively, collected with the Belle detector. No significant signals are observed in any of the proposed production modes, and the 90% credibility level upper limits on their branching fractions in ϒ (1 S ) and ϒ (2 S ) decays are obtained. The inclusive branching fractions of the ϒ (1 S ) and ϒ (2 S ) decays into final states with a χc 1 are measured to be B (ϒ (1 S )→χc 1+anything)=(1.90 ±0.43 (stat )±0.14 (syst ))×10-4 with an improved precision over prior measurements and B (ϒ (2 S )→χc 1+anything)=(2.24 ±0.44 (stat )±0.20 (syst ))×10-4 for the first time.

  15. Cadmium Telluride, Cadmium Telluride/Cadmium Sulfide Core/Shell, and Cadmium Telluride/Cadmium Sulfide/Zinc Sulfide Core/Shell/Shell Quantum Dots Study

    NASA Astrophysics Data System (ADS)

    Yan, Yueran

    aqueous phase can quench CdTe/CdS QDs. Additionally, the stability of the different ligands capped CdTe/CdS QDs was tested by dialysis measurement, the hydrodynamic diameters of CdTe and CdTe/CdS core/shell QDs were measured by dynamic light scattering, and dissolving issue was found when CdTe and CdTe/CdS core/shell QDs were diluted in CHCl3. We have characterized the CdTe core and the CdTe/CdS core/shell QDs by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), small angle X-ray scattering (SAXS), and ICP-OES measurements. We have found that the CdTe core was of a zincblende structure, and the shell was a wurtzite structure. And the CdTe/CdS QDs were core/shell QDs instead of alloying QDs. We have also analyzed the photophysical properties of CdTe and CdTe/CdS core/shell QDs. Time-resolved photoluminescence (PL) measurements showed the emission decay lifetimes in the tens of nanoseconds. Additionally, ultrafast charge carrier relaxation dynamics of the CdTe core and CdTe/CdS core/shell QDs were studied by the femtosecond transient absorption (TA) spectroscopy. The transient absorption spectra of CdTe and CdTe/CdS core/shell QDs showed multiple bleaches, which have been assigned to the 1S3/2(h)-1S(e), 2S3/2(h)-1S(e), and 1P3/2(h)-1P(e) transitions. The spectral shifts of these bleaches after shell deposition have been analyzed in the context of a quasi-type-II carrier distribution in the core/shell samples, and interestingly the red shift was only contributed from the conduction band energy levels shifting to lower energy. In addition, the ultrafast evolution of these bleach features has been examined to extract electron cooling rates in these samples. A fast decay component in the 1S3/2(h)-1S(e) transition of the small CdTe QDs was discovered due to the hole being trapped by the defects on the surface of QD. Further, we have studied the PL quenching process of the air exposed CdTe QDs via the PL decay and transient absorption measurements. Oxygen

  16. A study of angle-resolved photoemission extended fine structure as applied to the Ni 3p, Cu 3s, and Cu 3p core levels of the respective clean (111) surfaces

    SciTech Connect

    Huff, W.R.A.; Moler, E.J.; Kellar, S.A.

    1997-04-01

    The first non-s initial state angle-resolved photoemission extended fine structure (ARPEFS) study of clean surfaces for the purpose of further understanding the technique is reported. The surface structure sensitivity of ARPEFS applied to clean surfaces and to arbitrary initial states is studied using normal photoemission data taken from the Ni 3p core levels of a Ni(111) single crystal and the Cu 3s and the Cu 3p core-levels of a Cu(111) single crystal. The Fourier transforms of these clean surface data are dominated by backscattering. Unlike the s initial state data, the p initial state data show a peak in the Fourier transform corresponding to in-plane scattering from the six nearest-neighbors to the emitter. Evidence was seen for single-scattering events from in the same plane as the emitters and double-scattering events. Using a newly developed, multiple-scattering calculation program, ARPEFS data from clean surfaces and from p initial states can be modeled to high precision. Although there are many layers of emitters when measuring photoemission from a clean surface, test calculations show that the ARPEFS signal is dominated by photoemission from atoms in the first two crystal layers. Thus, ARPEFS applied to clean surfaces is sensitive to surface reconstruction. The known contraction of the first two Cu(111) layers is confirmed. The best-fit calculation for clean Ni(111) indicates an expansion of the first two layers. To better understand the ARPEFS technique, the authors studied s and non-s initial state photoemission from clean metal surfaces.

  17. Synthetic Core Promoters for Pichia pastoris

    PubMed Central

    2013-01-01

    Synthetic promoters are commonly used tools for circuit design or high level protein production. Promoter engineering efforts in yeasts, such as Saccharomyces cerevisiae and Pichia pastoris have mostly been focused on altering upstream regulatory sequences such as transcription factor binding sites. In higher eukaryotes synthetic core promoters, directly needed for transcription initiation by RNA Polymerase II, have been successfully designed. Here we report the first synthetic yeast core promoter for P. pastoris, based on natural yeast core promoters. Furthermore we used this synthetic core promoter sequence to engineer the core promoter of the natural AOX1 promoter, thereby creating a set of core promoters providing a range of different expression levels. As opposed to engineering strategies of the significantly longer entire promoter, such short core promoters can directly be added on a PCR primer facilitating library generation and are sufficient to obtain variable expression yields. PMID:24187969

  18. LB1's virtual endocast, microcephaly, and hominin brain evolution.

    PubMed

    Falk, Dean; Hildebolt, Charles; Smith, Kirk; Morwood, M J; Sutikna, Thomas; Jatmiko; Wayhu Saptomo, E; Prior, Fred

    2009-11-01

    Earlier observations of the virtual endocast of LB1, the type specimen for Homo floresiensis, are reviewed, extended, and interpreted. Seven derived features of LB1's cerebral cortex are detailed: a caudally-positioned occipital lobe, lack of a rostrally-located lunate sulcus, a caudally-expanded temporal lobe, advanced morphology of the lateral prefrontal cortex, shape of the rostral prefrontal cortex, enlarged gyri in the frontopolar region, and an expanded orbitofrontal cortex. These features indicate that LB1's brain was globally reorganized despite its ape-sized cranial capacity (417cm(3)). Neurological reorganization may thus form the basis for the cognitive abilities attributed to H. floresiensis. Because of its tiny cranial capacity, some workers think that LB1 represents a Homo sapiens individual that was afflicted with microcephaly, or some other pathology, rather than a new species of hominin. We respond to concerns about our earlier study of microcephalics compared with normal individuals, and reaffirm that LB1 did not suffer from this pathology. The intense controversy about LB1 reflects an older continuing dispute about the relative evolutionary importance of brain size versus neurological reorganization. LB1 may help resolve this debate and illuminate constraints that governed hominin brain evolution.

  19. Core and Off-Core Processes in Systems Engineering

    NASA Technical Reports Server (NTRS)

    Breidenthal, Julian; Forsberg, Kevin

    2010-01-01

    An emerging methodology of organizing systems-engineering plans is based on a concept of core and off-core processes or activities. This concept has emerged as a result of recognition of a risk in the traditional representation of systems-engineering plans by a Vee model alone, according to which a large system is decomposed into levels of smaller subsystems, then integrated through levels of increasing scope until the full system is constructed. Actual systems-engineering activity is more complicated, raising the possibility that the staff will become confused in the absence of plans which explain the nature and ordering of work beyond the traditional Vee model.

  20. Measurement of the muonium 1S-2S transition frequency

    SciTech Connect

    Jungmann, K.; Baird, P.E.G.; Barr, J.R.M.; Berkeland, D.; Boshier, M.G.; Braun, B.; Eaton, G.H.; Ferguson, A.I.; Geerds, H.; Hughes, V.W.; Maas, F.; Matthias, B.E.; Matousek, P.; Persaud, M.; zu Putlitz, G.; Reinhard, I.; Riis, E.; Sandars, P.G.H.; Schwarz, W.; Toner, W.T.; Towrie, M.; Willmann, L.; Woodle, K.A.; Woodman, G.

    1995-04-01

    Resonant ionization spectroscopy has been employed for measuring the 1{sup 2}{ital S}{sub 1/2}{minus}2{sup 2}{ital S}{sub 1/2} frequency difference in the hydrogen-like muonium atom to 2 455 529 002(33)(46) MHz. The 1S-2S two-photon transition was induced Doppler-free using two counter-propagating laser beams. The 2S state was photo-ionized by a third photon from the same laser field. The measurement agrees with QED theory within two standard deviations. The mass of the positive muon can be extracted from the isotope shifts in this transition to hydrogen and deuterium to 105.658 80(29)(43) MeV/c{sup 2}. {copyright} 1995 {ital American} {ital Institute} {ital of} {ital Physics}

  1. Measurement of the muonium 1S-2S transition frequency

    SciTech Connect

    Jungmann, K.; Baird, P. E. G.; Barr, J. R. M.; Berkeland, D.; Boshier, M. G.; Braun, B.; Eaton, G. H.; Ferguson, A. I.; Geerds, H.; Hughes, V. W.; Maas, F.; Matthias, B. E.; Matousek, P.; Persaud, M.; Putlitz, G. zu; Reinhard, I.; Riis, E.; Sandars, P. G. H.; Schwarz, W.; Toner, W. T.

    1995-04-01

    Resonant ionization spectroscopy has been employed for measuring the 1{sup 2}S1/2-2{sup 2}S1/2 frequency difference in the hydrogen-like muonium atom to 2 455 529 002(33)(46) MHz. The 1S-2S two-photon transition was induced Doppler-free using two counter-propagating laser beams. The 2S state was photo-ionized by a third photon from the same laser field. The measurement agrees with QED theory within two standard deviations. The mass of the positive muon can be extracted from the isotope shifts in this transition to hydrogen and deuterium to 105.658 80(29)(43) MeV/c{sup 2}.

  2. Core design and performance of small inherently safe LMRs

    SciTech Connect

    Orechwa, Y.; Khalil, H.; Turski, R.B.; Fujita, E.K.

    1986-01-01

    Oxide and metal-fueled core designs at the 900 MWt level and constrained by a requirement for interchangeability are described. The physics parameters of the two cores studied here indicate that metal-fueled cores display attractive economic and safety features and are more flexible than are oxide cores in adapting to currently-changing deployment scenarios.

  3. Inner Core Rotation from Geomagnetic Westward Drift and a Stationary Spherical Vortex in Earth's Core

    NASA Technical Reports Server (NTRS)

    Voorhies, C. V.

    1999-01-01

    The idea that geomagnetic westward drift indicates convective leveling of the planetary momentum gradient within Earth's core is pursued in search of a differentially rotating mean state, upon which various oscillations and secular effects might be superimposed. The desired state conforms to roughly spherical boundary conditions, minimizes dissipative interference with convective cooling in the bulk of the core, yet may aide core cooling by depositing heat in the uppermost core and lower mantle. The variational calculus of stationary dissipation applied to a spherical vortex within the core yields an interesting differential rotation profile akin to spherical Couette flow bounded by thin Hartmann layers. Four boundary conditions are required. To concentrate shear induced dissipation near the core-mantle boundary, these are taken to be: (i) no-slip at the core-mantle interface; (ii) geomagnetically estimated bulk westward flow at the base of the core-mantle boundary layer; (iii) no-slip at the inner-outer core interface; and, to describe magnetic locking of the inner core to the deep outer core, (iv) hydrodynamically stress-free at the inner-outer core boundary. By boldly assuming the axial core angular momentum anomaly to be zero, the super-rotation of the inner core is calculated to be at most 1.5 degrees per year.

  4. Inner Core Rotation from Geomagnetic Westward Drift and a Stationary Spherical Vortex in Earth's Core

    NASA Technical Reports Server (NTRS)

    Voorhies, Coerte V.

    1998-01-01

    The idea that geomagnetic westward drift indicates convective leveling of the planetary momentum gradient within Earth's core is pursued in search of a differentially rotating mean state, upon which various oscillations and secular effects might be superimposed. The desired state conforms to roughly spherical boundary conditions, minimizes dissipative interference with convective cooling in the bulk of the core, yet may aid core cooling by depositing heat in the uppermost core and lower mantle. The variational calculus of stationary dissipation applied to a spherical vortex within the core yields an interesting differential rotation profile, akin to spherical Couette flow bounded by thin Hartmann layers. Four boundary conditions are required. To concentrate shear induced dissipation near the core-mantle boundary, these are taken to be: (i) no-slip at the core-mantle interface; (ii) geomagnetically estimated bulk westward flow at the base of the core-mantle boundary layer; (iii) no-slip at the inner-outer core interface; and, to describe magnetic locking of the inner core to the deep outer core; (iv) hydrodynamically stress-free at the inner-outer core boundary. By boldly assuming the axial core angular momentum anomaly to be zero, the super-rotation of the inner core relative to the mantle is calculated to be at most 1.5 deg./yr.

  5. Technical note: simultaneous identification of CSN1S2 A, B, C, and E alleles in goats by polymerase chain reaction-single strand conformation polymorphism.

    PubMed

    Chessa, S; Rignanese, D; Chiatti, F; Radeghieri, A; Gigliotti, C; Caroli, A

    2008-03-01

    Most variability in goat caseins originates from the high number of genetic polymorphisms often affecting the specific protein expression, with strong effects on milk composition traits and technological properties. At least 7 alleles have been found in the goat alpha(S2)-CN gene (CSN1S2). Five of them (CSN1S2*A, CSN1S2*B, CSN1S2*C, CSN1S2*E, and CSN1S2*F) are widespread in most breeds, whereas the other 2 (CSN1S2*D and CSN1S2*0) are rarer alleles. Four different PCR-RFLP tests are needed to detect all of these variants at the DNA level. The objective of this study was to develop and validate a rapid method for typing 4 of the 5 most-common goat CSN1S2 alleles by means of PCR-single strand conformation polymorphism (SSCP). The method was validated by analyzing 37 goat samples at the protein and DNA level, respectively, by milk isoelectrofocusing and PCR-RFLP methods already described. The genotypes obtained using the PCR-SSCP approach were in full agreement with those obtained by the validation analyses. The newly developed PCR-SSCP approach provides an accurate and inexpensive assay highly suitable for genotyping goat CSN1S2.

  6. Academic Rigor: The Core of the Core

    ERIC Educational Resources Information Center

    Brunner, Judy

    2013-01-01

    Some educators see the Common Core State Standards as reason for stress, most recognize the positive possibilities associated with them and are willing to make the professional commitment to implementing them so that academic rigor for all students will increase. But business leaders, parents, and the authors of the Common Core are not the only…

  7. Balanced Production of Ribosome Components Is Required for Proper G1/S Transition in Saccharomyces cerevisiae *

    PubMed Central

    Gómez-Herreros, Fernando; Rodríguez-Galán, Olga; Morillo-Huesca, Macarena; Maya, Douglas; Arista-Romero, María; de la Cruz, Jesús; Chávez, Sebastián; Muñoz-Centeno, Mari Cruz

    2013-01-01

    Cell cycle regulation is a very accurate process that ensures cell viability and the genomic integrity of daughter cells. A fundamental part of this regulation consists in the arrest of the cycle at particular points to ensure the completion of a previous event, to repair cellular damage, or to avoid progression in potentially risky situations. In this work, we demonstrate that a reduction in nucleotide levels or the depletion of RNA polymerase I or III subunits generates a cell cycle delay at the G1/S transition in Saccharomyces cerevisiae. This delay is concomitant with an imbalance between ribosomal RNAs and proteins which, among others, provokes an accumulation of free ribosomal protein L5. Consistently with a direct impact of free L5 on the G1/S transition, rrs1 mutants, which weaken the assembly of L5 and L11 on pre-60S ribosomal particles, enhance both the G1/S delay and the accumulation of free ribosomal protein L5. We propose the existence of a surveillance mechanism that couples the balanced production of yeast ribosomal components and cell cycle progression through the accumulation of free ribosomal proteins. This regulatory pathway resembles the p53-dependent nucleolar-stress checkpoint response described in human cells, which indicates that this is a general control strategy extended throughout eukaryotes. PMID:24043628

  8. O(1S → 1D,3P) branching ratio as measured in the terrestrial nightglow

    NASA Astrophysics Data System (ADS)

    Slanger, T. G.; Cosby, P. C.; Sharpee, B. D.; Minschwaner, K. R.; Siskind, D. E.

    2006-12-01

    The branching ratio of the two optically forbidden atmospheric emission lines, O(1S - 1D) at 557.7 nm and O(1S - 3P) at 297.2 nm, is a fixed number in the upper atmosphere because the O(1S) level is common to both lines. The value for the ratio A(557.7)/A(297.2) currently recommended by NIST is 16.7, and the ratio found in the laboratory is somewhat larger. Field observations require space-based instruments, in which case calibration between the two wavelength regions is the critical issue. We circumvent this problem by using the O2(A-X) Herzberg I emission system as a bridge between the UV region below 310 nm and the ground-accessible region above that wavelength. These two spectral regions can be separately calibrated in terms of intensity, and the results of a disparate set of observations (satellite, rocket, ground-based sky spectra) lead to a quite consistent value of 9.8 ± 1.0 for A(557.7)/A(297.2). This conclusion has consequences for auroral and dayglow processes and for spectral calibration. It is particularly important to ascertain the cause of the substantial difference between this value and those from theory.

  9. Ionization energies and term energies of the ground states 1s22s of lithium-like systems

    NASA Astrophysics Data System (ADS)

    Li, Jin-Ying; Wang, Zhi-Wen

    2014-01-01

    We extend the Hamiltonian method of the full-core plus correlation (FCPC) by minimizing the expectation value to calculate the non-relativistic energies and the wave functions of 1s22s states for the lithium-like systems from Z = 41 to 50. The mass-polarization and the relativistic corrections including the kinetic-energy correction, the Darwin term, the electron—electron contact term, and the orbit—orbit interaction are calculated perturbatively as first-order correction. The contribution from quantum electrodynamic (QED) is also explored by using the effective nuclear charge formula. The ionization potential and term energies of the ground states 1s22s are derived and compared with other theoretical calculation results. It is shown that the FCPC methods are also effective for theoretical calculation of the ionic structure for high nuclear ion of lithium-like systems.

  10. Satellite structure in the Argon 1s photoelectron spectrum

    SciTech Connect

    Azuma, Y.; LeBrun, T.; MacDonald, M.; Southworth, S.H.

    1995-08-01

    Atomic inner-shell photoelectron spectra typically display several relatively weak {open_quotes}satellite peaks{close_quotes} at higher ionization energy than the primary peak. Such satellite peaks are associated with final-state configurations corresponding to ionization of an inner-shell electron and excitation or ionization of one or more valence electrons. The observation of satellite peaks demonstrates that the independent-electron picture is inadequate to describe atomic structure and the photoionization process. The measured energies and intensities of photoelectron satellites provide sensitive tests of many-electron theoretical models. We recorded the Ar 1s photoelectron spectrum on beam line X-24A at an X-ray energy of 3628 eV. The primary peak at 3206 eV ionization energy was recorded at an observed resolution of 1.8 eV (FWHM). The satellite structure shows remarkable similarity to that recorded in the suprathreshold region of the Ar K photoabsorption cross section, demonstrating the manner in which these techniques complement each other. Surprisingly, while the region just above the K threshold in Ar was the subject of several theoretical studies using multi-configuration calculations, we find good agreement between our results and those of Dyall and collaborators using a shake model.

  11. Quantitative first-principles calculations of valence and core excitation spectra of solid C60

    NASA Astrophysics Data System (ADS)

    Fossard, F.; Hug, G.; Gilmore, K.; Kas, J. J.; Rehr, J. J.; Vila, F. D.; Shirley, E. L.

    2017-03-01

    We present calculated valence and C 1 s near-edge excitation spectra of solid C60 and experimental results measured with high-resolution electron energy-loss spectroscopy. The near-edge calculations are carried out using three different methods: solution of the Bethe-Salpeter equation (BSE) as implemented in the ocean suite (Obtaining Core Excitations with Ab Initio methods and the NIST BSE solver), the excited-electron core-hole approach, and the constrained-occupancy method using the Stockholm-Berlin core excitation code, StoBe. The three methods give similar results and are in good agreement with experiment, though the BSE results are the most accurate. The BSE formalism is also used to carry out valence level calculations using the NIST BSE solver. Theoretical results include self-energy corrections to the band gap and bandwidths, lifetime-damping effects, and Debye-Waller effects in the core excitation case. A comparison of spectral features to those observed experimentally illustrates the sensitivity of certain features to computational details, such as self-energy corrections to the band structure and core-hole screening.

  12. The − 5 A/G single-nucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer

    SciTech Connect

    Starska, Katarzyna; Krześlak, Anna; Forma, Ewa; Morawiec-Sztandera, Alina; Aleksandrowicz, Paweł; Lewy-Trenda, Iwona; and others

    2014-10-15

    Metallothioneins (MTs) are low molecular weight, cysteine-rich heavy metal-binding proteins which participate in the mechanisms of Zn homeostasis, and protect against toxic metals. MTs contain metal-thiolate cluster groups and suppress metal toxicity by binding to them. The aim of this study was to determine the − 5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene and to investigate its effect on allele-specific gene expression and Cd, Zn and Cu content in squamous cell laryngeal cancer (SCC) and non-cancerous laryngeal mucosa (NCM) as a control. The MT2A promoter region − 5 A/G SNP was determined by restriction fragment length polymorphism using 323 SCC and 116 NCM. MT2A gene analysis was performed by quantitative real-time PCR. The frequency of A allele carriage was 94.2% and 91.8% in SCC and NCM, respectively, while G allele carriage was detected in 5.8% and 8.2% of SCC and NCM samples, respectively. As a result, a significant association was identified between the − 5 A/G SNP in the MT2A gene with mRNA expression in both groups. Metal levels were analyzed by flame atomic absorption spectrometry. The significant differences were identified between A/A and both the A/G and G/G genotypes, with regard to the concentration of the contaminating metal. The Spearman rank correlation results showed that the MT2A expression and Cd, Zn, Cu levels were negatively correlated. Results obtained in this study suggest that − 5 A/G SNP in MT2A gene may have an effect on allele-specific gene expression and accumulation of metal levels in laryngeal cancer. - Highlights: • MT2A gene expression and metal content in laryngeal cancer tissues • Association between SNP (rs28366003) and expression of MT2A • Significant associations between the SNP and Cd, Zn and Cu levels • Negative correlation between MT2A gene expression and Cd, Zn and Cu levels.

  13. Core to College Evaluation: Exploring the Use of Multiple Measures for Placement into College-Level Courses. Seeking Alternatives or Improvements to the Use of a Single Standardized Test

    ERIC Educational Resources Information Center

    Bracco, Kathy Reeves; Dadgar, Mina; Austin, Kim; Klarin, Becca; Broek, Marie; Finkelstein, Neal; Mundry, Susan; Bugler, Dan

    2014-01-01

    "Core to College: Preparing Students for College Readiness and Success" is a three-year initiative. The initiative's mission is to "facilitate greater coordination between K-12 and postsecondary education systems around implementation of the Common Core State Standards (CCSS) and aligned assessments." Its aim is to foster…

  14. MR-1S Interacts with PET100 and PET117 in Module-Based Assembly of Human Cytochrome c Oxidase.

    PubMed

    Vidoni, Sara; Harbour, Michael E; Guerrero-Castillo, Sergio; Signes, Alba; Ding, Shujing; Fearnley, Ian M; Taylor, Robert W; Tiranti, Valeria; Arnold, Susanne; Fernandez-Vizarra, Erika; Zeviani, Massimo

    2017-02-14

    The biogenesis of human cytochrome c oxidase (COX) is an intricate process in which three mitochondrial DNA (mtDNA)-encoded core subunits are assembled in a coordinated way with at least 11 nucleus-encoded subunits. Many chaperones shared between yeast and humans are involved in COX assembly. Here, we have used a MT-CO3 mutant cybrid cell line to define the composition of assembly intermediates and identify new human COX assembly factors. Quantitative mass spectrometry analysis led us to modify the assembly model from a sequential pathway to a module-based process. Each module contains one of the three core subunits, together with different ancillary components, including HIGD1A. By the same analysis, we identified the short isoform of the myofibrillogenesis regulator 1 (MR-1S) as a new COX assembly factor, which works with the highly conserved PET100 and PET117 chaperones to assist COX biogenesis in higher eukaryotes.

  15. Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA

    PubMed Central

    Sosa-Jurado, Francisca; Hilda Rosas-Murrieta, Nora; Guzman-Flores, Belinda; Perez Zempoaltecalt, Cintia; Patricia Sanchez Torres, Ana; Ramirez Rosete, Leticia; Bernal-Soto, Maribel; Marquez-Dominguez, Luis; Melendez-Mena, Daniel; Angel Mendoza Torres, Miguel; Teresa Lopez Delgado, Maria; Reyes-Leyva, Julio; Vallejo-Ruiz, Veronica; Santos-Lopez, Gerardo

    2016-01-01

    Background The hepatitis B virus (HBV) causes chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. Surface antigen (HBsAg) detection is a definitive test that can confirm HBV infection, while the presence of antibodies against the core protein (anti-HBc) suggests either a previous or ongoing infection or occult hepatitis B infection (OBI). Objectives The aim of the present study was to determine the prevalence of anti-HBc and HBsAg in blood donors. Further, the study aimed to estimate the anti-HBc level at which HBV DNA is detected in putative OBI cases, as well as to search for mutations in the “a” determinant associated with the non-detection of HBsAg in serum. Patients and Methods We conducted a cross-sectional study from 2003–2009. The study included 120,552 blood donors from the state of Puebla, Mexico. Different commercial systems based on microparticles (enzymatic (MEIA) or chemiluminescent (CMIA)) were used to determine the HBsAg and anti-HBc levels. For the detection of HBV DNA, a nested polymerase chain reaction (nested PCR) was used and the genotypes were determined using Sanger sequencing. Results Of the 120,552 blood donors, 1437 (1.19%, 95% CI: 1.12 - 1.26) were reactive to anti-HBc, while 82 (0.066%, 95% CI: 0.053 - 0.079) were reactive to HBsAg. Some 156 plasma samples collected in 2009 from anti-HBc-positive/HBsAg-negative blood donors were submitted for HBV DNA detection in a search for probable OBI. Viral DNA was detected in 27/156 (17.3%, 95% CI: 11.5 - 23.1). Our results show an association between HBV DNA or HBsAg and anti-HBc S/CO levels ≥ 4.0. All DNA samples were identified as genotype H and some “a” determinant mutations were identified, although none corresponded to mutations previously reported to hinder the detection of HBsAg by commercial immunoassays. Conclusions We observed that as the anti-HBc levels increase, there is a higher prevalence of the viral protein HBsAg in blood donors. Samples testing positive

  16. HTTF Core Stress Analysis

    SciTech Connect

    Brian D. Hawkes; Richard Schultz

    2012-07-01

    In accordance with the need to determine whether cracking of the ceramic core disks which will be constructed and used in the High Temperature Test Facility (HTTF) for heatup and cooldown experiments, a set of calculation were performed using Abaqus to investigate the thermal stresses levels and likelihood for cracking. The calculations showed that using the material properties provided for the Greencast 94F ceramic, cracking is predicted to occur. However, this modeling does not predict the size or length of the actual cracks. It is quite likely that cracks will be narrow with rough walls which would impede the flow of coolant gases entering the cracks. Based on data recorded at Oregon State University using Greencast 94F samples that were heated and cooled at prescribed rates, it was concluded that the likelihood that the cracks would be detrimental to the experimental objectives is small.

  17. Coring Sample Acquisition Tool

    NASA Technical Reports Server (NTRS)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  18. Reactor core isolation cooling system

    DOEpatents

    Cooke, F.E.

    1992-12-08

    A reactor core isolation cooling system includes a reactor pressure vessel containing a reactor core, a drywell vessel, a containment vessel, and an isolation pool containing an isolation condenser. A turbine is operatively joined to the pressure vessel outlet steamline and powers a pump operatively joined to the pressure vessel feedwater line. In operation, steam from the pressure vessel powers the turbine which in turn powers the pump to pump makeup water from a pool to the feedwater line into the pressure vessel for maintaining water level over the reactor core. Steam discharged from the turbine is channeled to the isolation condenser and is condensed therein. The resulting heat is discharged into the isolation pool and vented to the atmosphere outside the containment vessel for removing heat therefrom. 1 figure.

  19. Reactor core isolation cooling system

    DOEpatents

    Cooke, Franklin E.

    1992-01-01

    A reactor core isolation cooling system includes a reactor pressure vessel containing a reactor core, a drywell vessel, a containment vessel, and an isolation pool containing an isolation condenser. A turbine is operatively joined to the pressure vessel outlet steamline and powers a pump operatively joined to the pressure vessel feedwater line. In operation, steam from the pressure vessel powers the turbine which in turn powers the pump to pump makeup water from a pool to the feedwater line into the pressure vessel for maintaining water level over the reactor core. Steam discharged from the turbine is channeled to the isolation condenser and is condensed therein. The resulting heat is discharged into the isolation pool and vented to the atmosphere outside the containment vessel for removing heat therefrom.

  20. Challenges Regarding IP Core Functional Reliability

    NASA Technical Reports Server (NTRS)

    Berg, Melanie D.; LaBel, Kenneth A.

    2017-01-01

    For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

  1. Molecular Characterization of the Llamas (Lama glama) Casein Cluster Genes Transcripts (CSN1S1, CSN2, CSN1S2, CSN3) and Regulatory Regions

    PubMed Central

    Pauciullo, Alfredo; Erhardt, Georg

    2015-01-01

    In the present paper, we report for the first time the characterization of llama (Lama glama) caseins at transcriptomic and genetic level. A total of 288 casein clones transcripts were analysed from two lactating llamas. The most represented mRNA populations were those correctly assembled (85.07%) and they encoded for mature proteins of 215, 217, 187 and 162 amino acids respectively for the CSN1S1, CSN2, CSN1S2 and CSN3 genes. The exonic subdivision evidenced a structure made of 21, 9, 17 and 6 exons for the αs1-, β-, αs2- and κ-casein genes respectively. Exon skipping and duplication events were evidenced. Two variants A and B were identified in the αs1-casein gene as result of the alternative out-splicing of the exon 18. An additional exon coding for a novel esapeptide was found to be cryptic in the κ-casein gene, whereas one extra exon was found in the αs2-casein gene by the comparison with the Camelus dromedaries sequence. A total of 28 putative phosphorylated motifs highlighted a complex heterogeneity and a potential variable degree of post-translational modifications. Ninety-six polymorphic sites were found through the comparison of the lama casein cDNAs with the homologous camel sequences, whereas the first description and characterization of the 5’- and 3’-regulatory regions allowed to identify the main putative consensus sequences involved in the casein genes expression, thus opening the way to new investigations -so far- never achieved in this species. PMID:25923814

  2. Molecular Characterization of the Llamas (Lama glama) Casein Cluster Genes Transcripts (CSN1S1, CSN2, CSN1S2, CSN3) and Regulatory Regions.

    PubMed

    Pauciullo, Alfredo; Erhardt, Georg

    2015-01-01

    In the present paper, we report for the first time the characterization of llama (Lama glama) caseins at transcriptomic and genetic level. A total of 288 casein clones transcripts were analysed from two lactating llamas. The most represented mRNA populations were those correctly assembled (85.07%) and they encoded for mature proteins of 215, 217, 187 and 162 amino acids respectively for the CSN1S1, CSN2, CSN1S2 and CSN3 genes. The exonic subdivision evidenced a structure made of 21, 9, 17 and 6 exons for the αs1-, β-, αs2- and κ-casein genes respectively. Exon skipping and duplication events were evidenced. Two variants A and B were identified in the αs1-casein gene as result of the alternative out-splicing of the exon 18. An additional exon coding for a novel esapeptide was found to be cryptic in the κ-casein gene, whereas one extra exon was found in the αs2-casein gene by the comparison with the Camelus dromedaries sequence. A total of 28 putative phosphorylated motifs highlighted a complex heterogeneity and a potential variable degree of post-translational modifications. Ninety-six polymorphic sites were found through the comparison of the lama casein cDNAs with the homologous camel sequences, whereas the first description and characterization of the 5'- and 3'-regulatory regions allowed to identify the main putative consensus sequences involved in the casein genes expression, thus opening the way to new investigations -so far- never achieved in this species.

  3. Banded transformer cores

    NASA Technical Reports Server (NTRS)

    Mclyman, C. W. T. (Inventor)

    1974-01-01

    A banded transformer core formed by positioning a pair of mated, similar core halves on a supporting pedestal. The core halves are encircled with a strap, selectively applying tension whereby a compressive force is applied to the core edge for reducing the innate air gap. A dc magnetic field is employed in supporting the core halves during initial phases of the banding operation, while an ac magnetic field subsequently is employed for detecting dimension changes occurring in the air gaps as tension is applied to the strap.

  4. Ψ(2 S) Decay to J/Ψ(1 S) + 2 π or J/Ψ(1 S) + σ + 2 π

    NASA Astrophysics Data System (ADS)

    Kisslinger, Leonard S.; Li-juan, Zhou; Wei-xing, Ma; Shen, Pengnian

    2017-03-01

    We estimate the decay rate of the Ψ(2 S) to J/Ψ(1 S) + 2 π and J/Ψ(1 S) + σ + 2 π. This is based on the mixed hybrid theory that was developed for the Ψ(2 S) and was used to estimate the ratio {Ψ }(2S)→ J/{Ψ }(1S) + σ to {Ψ }(2S) → J/{Ψ }(1S) + 2 π in 2011. A main motivation of the present work is to predict the possible experimental detection of the decay of Ψ(2 S) to J/Ψ(1 S) + σ+2 π, or possibly to J/Ψ(1 S)+2 π+glueball.

  5. Determination of electron-impact transfer rate coefficients between argon 1s2 and 1s3 states by laser pump-probe technique

    NASA Astrophysics Data System (ADS)

    Carbone, E. A. D.; Hübner, S.; van der Mullen, J. J. A. M.; Kroesen, G. M. W.; Sadeghi, N.

    2013-10-01

    In a microwave argon plasma, the electron-impact population transfers between the first four excited states of argon are studied by time-resolved laser pump-probe technique. Metastable atoms in the 1s5 state (in Paschen's notation) are selectively pumped up to the 2p3 state, with a nanosecond pulsed dye laser tuned to the 706 nm argon transition and the temporal response of the densities in the 1s3, 1s4 and 1s5 states are monitored by time-resolved laser diode absorption. The electron density and temperature are also measured by Thomson scattering along the plasma column for different pressures. The rate coefficient measured for the 1s3 to 1s2 state transfer, for which only rough estimations exist in the literature is found to be 9 × 10-13 m3 s-1, almost five times larger than the value commonly assumed.

  6. Outer-core emission spectra of heavy alkali metals

    NASA Astrophysics Data System (ADS)

    Fink, R. L.; First, P. N.; Flynn, C. P.

    1988-09-01

    We report np5(n+1)s2-->np6(n+1)s emission spectra of K (n=3), Rb (n=4), and Cs (n=5), and compare emission-band characteristics through the series Na-Cs using earlier data for Na. The normalized band profiles of the different alkali metals are remarkably similar when scaled by the Fermi energy EF. However, the spin-orbit partner intensity ratios are far from the ideal value 2, reaching approximately 60 for Rb and above 65 for Cs, mainly owing to Coster-Kronig decays from higher levels. We confirm that the Mahan-Nozières-De Dominicis ``anomaly'' at EF is generally weaker in emission than in absorption. It decreases through the series to become undetectable for emission from Cs. A systematic increase of the core-hole-lifetime width occurs through the column of alkali metals from a reported estimate of 10 meV for Na to a value of 50 meV for Cs. A study of the Fermi-edge shape between 20 and 300 K reveals temperature-dependent phonon broadening in generally good agreement with theoretical predictions. Incomplete relaxation plays only a minor role in the edge processes of the heavy alkali metals. Additional Fermi-edge broadening and the shifted emission edges of surface atoms are observed for alkali-metal films 10-100 Å thick.

  7. Sex Steroids Regulate Expression of Genes Containing Long Interspersed Elements-1s in Breast Cancer Cells.

    PubMed

    Chaiwongwatanakul, Saichon; Yanatatsaneejit, Pattamawadee; Tongsima, Sissades; Mutirangura, Apiwat; Boonyaratanakornkit, Viroj

    2016-01-01

    Long interspersed elements-1s (LINE-1s) are dispersed all over the human genome. There is evidence that hypomethylation of LINE-1s and levels of sex steroids regulate gene expression leading to cancer development. Here, we compared mRNA levels of genes containing an intragenic LINE-1 in breast cancer cells treated with various sex steroids from Gene Expression Omnibus (GEO), with the gene expression database using chi-square analysis (http://www.ncbi.nlm.nih.gov/geo). We evaluated whether sex steroids influence expression of genes containing an intragenic LINE-1. Three sex steroids at various concentrations, 1 and 10 nM estradiol (E2), 10 nM progesterone (PG) and 10 nM androgen (AN), were assessed. In breast cancer cells treated with 1 or 10 nM E2, a significant percentage of genes containing an intragenic LINE-1 were down-regulated. A highly significant percentage of E2-regulated genes containing an intragenic LINE-1 was down-regulated in cells treated with 1 nM E2 for 3 hours (<3.70E-25; OR=1.91; 95% CI=2.16-1.69). Similarly, high percentages of PG or AN- regulated genes containing an intragenic LINE-1 were also down-regulated in cells treated with 10 nM PG or 10 nM AN for 16 hr (p=9.53E-06; OR=1.65; 95% CI=2.06-1.32 and p=3.81E-14; OR=2.01; 95% CI=2.42-1.67). Interestingly, a significant percentage of AN-regulated genes containing an intragenic LINE-1 was up-regulated in cells treated with 10 nM AN for 16 hr (p=4.03E-02; OR=1.40; 95% CI=1.95-1.01). These findings suggest that intragenic LINE-1s may play roles in sex steroid mediated gene expression in breast cancer cells, which could have significant implications for the development and progression of sex steroid-dependent cancers.

  8. Deduction of the chemical state and the electronic structure of Nd{sub 2}Fe{sub 14}B compound from X-ray photoelectron spectroscopy core-level and valence-band spectra

    SciTech Connect

    Wang, Jing; Liang, Le; Zhang, Lanting E-mail: lmsun@sjtu.edu.cn; Sun, Limin E-mail: lmsun@sjtu.edu.cn; Hirano, Shinichi

    2014-10-28

    Characterization of chemical state and electronic structure of the technologically important Nd{sub 2}Fe{sub 14}B compound is attractive for understanding the physical nature of its excellent magnetic properties. X-ray photoelectron spectroscopy (XPS) study of such rare-earth compound is important and also challenging due to the easy oxidation of surface and small photoelectron cross-sections of rare-earth 4f electrons and B 2p electrons, etc. Here, we reported an investigation based on XPS spectra of Nd{sub 2}Fe{sub 14}B compound as a function of Ar ion sputtering time. The chemical state of Fe and that of B in Nd{sub 2}Fe{sub 14}B compound can be clearly determined to be 0 and −3, respectively. The Nd in Nd{sub 2}Fe{sub 14}B compound is found to have the chemical state of close to +3 instead of +3 as compared with the Nd in Nd{sub 2}O{sub 3}. In addition, by comparing the valence-band spectrum of Nd{sub 2}Fe{sub 14}B compound to that of the pure Fe, the contributions from Nd, Fe, and B to the valence-band structure of Nd{sub 2}Fe{sub 14}B compound is made more clear. The B 2p states and B 2s states are identified to be at ∼11.2 eV and ∼24.6 eV, respectively, which is reported for the first time. The contribution from Nd 4f states can be identified both in XPS core-level spectrum and XPS valence-band spectrum. Although Nd 4f states partially hybridize with Fe 3d states, Nd 4f states are mainly localized in Nd{sub 2}Fe{sub 14}B compound.

  9. HYDRATE CORE DRILLING TESTS

    SciTech Connect

    John H. Cohen; Thomas E. Williams; Ali G. Kadaster; Bill V. Liddell

    2002-11-01

    The ''Methane Hydrate Production from Alaskan Permafrost'' project is a three-year endeavor being conducted by Maurer Technology Inc. (MTI), Noble, and Anadarko Petroleum, in partnership with the U.S. DOE National Energy Technology Laboratory (NETL). The project's goal is to build on previous and ongoing R&D in the area of onshore hydrate deposition. The project team plans to design and implement a program to safely and economically drill, core and produce gas from arctic hydrates. The current work scope includes drilling and coring one well on Anadarko leases in FY 2003 during the winter drilling season. A specially built on-site core analysis laboratory will be used to determine some of the physical characteristics of the hydrates and surrounding rock. Prior to going to the field, the project team designed and conducted a controlled series of coring tests for simulating coring of hydrate formations. A variety of equipment and procedures were tested and modified to develop a practical solution for this special application. This Topical Report summarizes these coring tests. A special facility was designed and installed at MTI's Drilling Research Center (DRC) in Houston and used to conduct coring tests. Equipment and procedures were tested by cutting cores from frozen mixtures of sand and water supported by casing and designed to simulate hydrate formations. Tests were conducted with chilled drilling fluids. Tests showed that frozen core can be washed out and reduced in size by the action of the drilling fluid. Washing of the core by the drilling fluid caused a reduction in core diameter, making core recovery very difficult (if not impossible). One successful solution was to drill the last 6 inches of core dry (without fluid circulation). These tests demonstrated that it will be difficult to capture core when drilling in permafrost or hydrates without implementing certain safeguards. Among the coring tests was a simulated hydrate formation comprised of coarse, large

  10. 23. CORE WORKER OPERATING A COREBLOWER THAT PNEUMATICALLY FILLED CORE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. CORE WORKER OPERATING A CORE-BLOWER THAT PNEUMATICALLY FILLED CORE BOXES WITH RESIGN IMPREGNATED SAND AND CREATED A CORE THAT THEN REQUIRED BAKING, CA. 1950. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  11. Core-Cutoff Tool

    NASA Technical Reports Server (NTRS)

    Gheen, Darrell

    2007-01-01

    A tool makes a cut perpendicular to the cylindrical axis of a core hole at a predetermined depth to free the core at that depth. The tool does not damage the surrounding material from which the core was cut, and it operates within the core-hole kerf. Coring usually begins with use of a hole saw or a hollow cylindrical abrasive cutting tool to make an annular hole that leaves the core (sometimes called the plug ) in place. In this approach to coring as practiced heretofore, the core is removed forcibly in a manner chosen to shear the core, preferably at or near the greatest depth of the core hole. Unfortunately, such forcible removal often damages both the core and the surrounding material (see Figure 1). In an alternative prior approach, especially applicable to toxic or fragile material, a core is formed and freed by means of milling operations that generate much material waste. In contrast, the present tool eliminates the damage associated with the hole-saw approach and reduces the extent of milling operations (and, hence, reduces the waste) associated with the milling approach. The present tool (see Figure 2) includes an inner sleeve and an outer sleeve and resembles the hollow cylindrical tool used to cut the core hole. The sleeves are thin enough that this tool fits within the kerf of the core hole. The inner sleeve is attached to a shaft that, in turn, can be attached to a drill motor or handle for turning the tool. This tool also includes a cutting wire attached to the distal ends of both sleeves. The cutting wire is long enough that with sufficient relative rotation of the inner and outer sleeves, the wire can cut all the way to the center of the core. The tool is inserted in the kerf until its distal end is seated at the full depth. The inner sleeve is then turned. During turning, frictional drag on the outer core pulls the cutting wire into contact with the core. The cutting force of the wire against the core increases with the tension in the wire and

  12. Three-loop slope of the dirac form factor and the 1S lamb shift in hydrogen

    PubMed

    Melnikov; van Ritbergen T

    2000-02-21

    The last unknown contribution to hydrogen energy levels at order malpha(7), due to the slope of the Dirac form factor at three loops, is evaluated in a closed analytical form. The resulting shift of the hydrogen nS energy level is found to be 3.016/n(3) kHz. Using the QED calculations of the 1S Lamb shift, we extract a precise value of the proton charge radius r(p) = 0.883+/-0.014 fm.

  13. Search for a light Higgs resonance in radiative decays of the ϒ (1 S ) with a charm tag

    NASA Astrophysics Data System (ADS)

    Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Kerth, L. T.; Kolomensky, Yu. G.; Lee, M. J.; Lynch, G.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Dey, B.; Gary, J. W.; Long, O.; Franco Sevilla, M.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Röhrken, M.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Bernard, D.; Verderi, M.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Piemontese, L.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Bhuyan, B.; Prasad, V.; Adametz, A.; Uwer, U.; Lacker, H. M.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Cheaib, R.; Patel, P. M.; Robertson, S. H.; Neri, N.; Palombo, F.; Cremaldi, L.; Godang, R.; Summers, D. J.; Simard, M.; Taras, P.; De Nardo, G.; Onorato, G.; Sciacca, C.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Anulli, F.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Hess, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Vasseur, G.; Aston, D.; Bard, D. J.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Lindemann, D.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Wulsin, H. W.; Purohit, M. V.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P.; Albert, J.; Banerjee, Sw.; Beaulieu, A.; Bernlochner, F. U.; Choi, H. H. F.; King, G. J.; Kowalewski, R.; Lewczuk, M. J.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Band, H. R.; Dasu, S.; Pan, Y.; Prepost, R.; Wu, S. L.; BaBar Collaboration

    2015-04-01

    A search is presented for the decay ϒ (1 S )→γ A0 , A0→c c ¯, where A0 is a candidate for the C P -odd Higgs boson of the next-to-minimal supersymmetric standard model. The search is based on data collected with the BABAR detector at the ϒ (2 S ) resonance. A sample of ϒ (1 S ) mesons is selected via the decay ϒ (2 S )→π+π-ϒ (1 S ) . The A0→c c ¯ decay is identified through the reconstruction of hadronic D0, D+, and D*(2010 )+ meson decays. No significant signal is observed. The measured 90% confidence-level upper limits on the product branching fraction B (ϒ (1 S )→γ A0)×B (A0→c c ¯ ) range from 7.4 ×10-5 to 2.4 ×10-3 for A0 masses from 4.00 to 8.95 GeV /c2 and 9.10 to 9.25 GeV /c2 , where the region between 8.95 and 9.10 GeV /c2 is excluded because of background from ϒ (2 S )→γ χb J(1 P ) , χb J(1 P )→γ ϒ (1 S ) decays.

  14. Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed.

    PubMed

    Li, Wenjiao; Zou, Jing; Yue, Fei; Song, Kun; Chen, Qi; McKeehan, Wallace L; Wang, Fen; Xu, Guibin; Huang, Hai; Yi, Jinglin; Liu, Leyuan

    2016-04-01

    Autophagy is a cellular process that executes the turnover of dysfunctional organelles and misfolded or abnormally aggregated proteins. Microtubule-associated protein MAP1S interacts with autophagy marker LC3 and positively regulates autophagy flux. LC3 binds with fibronectinmRNA and facilitates its translation. The synthesized fibronectin protein is exported to cell surface to initiate the assembly of fibronectin extracellular matrix. Fibronectin is degraded in lysosomes after it is engulfed into cytosol via endocytosis. Here, we show that defects in MAP1S-mediated autophagy trigger oxidative stress, sinusoidal dilation, and lifespan reduction. Overexpression of LC3 in wild-type mice increases the levels of fibronectin and γ-H2 AX, a marker of DNA double-strand breakage. LC3-induced fibronectin is efficiently degraded in lysosomes to maintain a balance of fibronectin levels in wild-type mice so that the mice live a normal term of lifespan. In the LC3 transgenic mice with MAP1S deleted, LC3 enhances the synthesis of fibronectin but the MAP1S depletion causes an impairment of the lysosomal degradation of fibronectin. The accumulation of fibronectin protein promotes liver fibrosis, induces an accumulation of cell population at the G0/G1 stage, and further intensifies oxidative stress and sinusoidal dilatation. The LC3-induced overexpression of fibronectin imposes stresses on MAP1S-deficient mice and dramatically reduces their lifespans. Therefore, MAP1S-mediated autophagy plays an important role in maintaining mouse lifespan especially in the presence of extra amount of fibronectin.

  15. Identifying ELIXIR Core Data Resources

    PubMed Central

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2017-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR’s sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure. PMID:27803796

  16. Identifying ELIXIR Core Data Resources.

    PubMed

    Durinx, Christine; McEntyre, Jo; Appel, Ron; Apweiler, Rolf; Barlow, Mary; Blomberg, Niklas; Cook, Chuck; Gasteiger, Elisabeth; Kim, Jee-Hyub; Lopez, Rodrigo; Redaschi, Nicole; Stockinger, Heinz; Teixeira, Daniel; Valencia, Alfonso

    2016-01-01

    The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR's sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. The identification process is currently being implemented and tested for the first time. The findings and outcome will be evaluated by the ELIXIR Scientific Advisory Board in March 2017. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure.

  17. Core sample extractor

    NASA Technical Reports Server (NTRS)

    Akins, James; Cobb, Billy; Hart, Steve; Leaptrotte, Jeff; Milhollin, James; Pernik, Mark

    1989-01-01

    The problem of retrieving and storing core samples from a hole drilled on the lunar surface is addressed. The total depth of the hole in question is 50 meters with a maximum diameter of 100 millimeters. The core sample itself has a diameter of 60 millimeters and will be two meters in length. It is therefore necessary to retrieve and store 25 core samples per hole. The design utilizes a control system that will stop the mechanism at a certain depth, a cam-linkage system that will fracture the core, and a storage system that will save and catalogue the cores to be extracted. The Rod Changer and Storage Design Group will provide the necessary tooling to get into the hole as well as to the core. The mechanical design for the cam-linkage system as well as the conceptual design of the storage device are described.

  18. The core paradox.

    NASA Technical Reports Server (NTRS)

    Kennedy, G. C.; Higgins, G. H.

    1973-01-01

    Rebuttal of suggestions from various critics attempting to provide an escape from the seeming paradox originated by Higgins and Kennedy's (1971) proposed possibility that the liquid in the outer core was thermally stably stratified and that this stratification might prove a powerful inhibitor to circulation of the outer core fluid of the kind postulated for the generation of the earth's magnetic field. These suggestions are examined and shown to provide no reasonable escape from the core paradox.

  19. Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.

    PubMed

    Haimovici, Aladin; Brigger, Daniel; Torbett, Bruce E; Fey, Martin F; Tschan, Mario P

    2014-09-01

    The PU.1 transcription factor is essential for myeloid development. We investigated if the microtubule-associated protein 1S (MAP1S) is a novel PU.1 target with a link to autophagy, a cellular recycling pathway. Comparable to PU.1, MAP1S expression was significantly repressed in primary AML blasts as compared to mature neutrophils. Accordingly, MAP1S expression was induced during neutrophil differentiation of CD34(+) progenitor and APL cells. Moreover, PU.1 bound to the MAP1S promoter and induced MAP1S expression during APL differentiation. Inhibiting MAP1S resulted in aberrant neutrophil differentiation and autophagy. Taken together, our findings implicate the PU.1-regulated MAP1S gene in neutrophil differentiation and autophagy control.

  20. The O(1S - 1D,3P) Line Intensity Ratio

    NASA Astrophysics Data System (ADS)

    Slanger, T. G.; Sharpee, B. D.; Cosby, P. C.; Minschwaner, K. R.; Siskind, D. E.

    2005-05-01

    The line intensity ratio of the two optically-forbidden atmospheric emissions, O(1S-1D) at 557.7 nm and O(1S-3P) at 297.2 nm, must be a single-valued number in the upper atmosphere because the upper level is common to both lines. The calculated transition probability ratio A(557.7)/A(297.2) is 16, by several authors, and the ratio found in the laboratory is significantly larger. Field observations require space-based instruments, in which case calibration between the two wavelengths is the critical issue. We circumvent this problem by using the O2 Herzberg I emission system as a bridge between the UV region below 310 nm and the ground-accessible region above that wavelength. These two spectral regions can be separately calibrated in terms of intensity, and the results of a disparate set of observations (satellite, rocket, ground-based) lead to A(557.7)/A(297.2) ratios that are consistently much smaller than the calculated value. These results have consequences for auroral and dayglow processes, and it is particularly important to ascertain the cause of the substantial difference between theory and observation.

  1. Core Research Center

    USGS Publications Warehouse

    Hicks, Joshua; Adrian, Betty

    2009-01-01

    The Core Research Center (CRC) of the U.S. Geological Survey (USGS), located at the Denver Federal Center in Lakewood, Colo., currently houses rock core from more than 8,500 boreholes representing about 1.7 million feet of rock core from 35 States and cuttings from 54,000 boreholes representing 238 million feet of drilling in 28 States. Although most of the boreholes are located in the Rocky Mountain region, the geologic and geographic diversity of samples have helped the CRC become one of the largest and most heavily used public core repositories in the United States. Many of the boreholes represented in the collection were drilled for energy and mineral exploration, and many of the cores and cuttings were donated to the CRC by private companies in these industries. Some cores and cuttings were collected by the USGS along with other government agencies. Approximately one-half of the cores are slabbed and photographed. More than 18,000 thin sections and a large volume of analytical data from the cores and cuttings are also accessible. A growing collection of digital images of the cores are also becoming available on the CRC Web site Internet http://geology.cr.usgs.gov/crc/.

  2. Dynamics deep from the core

    PubMed Central

    Carbone, F.

    2015-01-01

    In van der Veen et al., [Struct. Dyn. 2, 024302 (2015)], femtosecond and nanosecond electron energy loss spectroscopy of deep core-levels are demonstrated. These results pave the way to the investigation of materials and molecules with combined energy, time, and spatial resolution in a transmission electron microscope. Furthermore, the authors elucidate the role of the electron phonon coupling in the band-gap renormalization that takes place in graphite upon photo-excitation. PMID:26798787

  3. Investigating the relationship between k-core and s-core network decompositions

    NASA Astrophysics Data System (ADS)

    Eidsaa, Marius; Almaas, Eivind

    2016-05-01

    Network decomposition methods, such as the much used k-core analysis, are able to identify globally central regions of networks. The decomposition approaches are hierarchical and identify nested sets of nodes with increasing centrality properties. While most studies have been concerned with unweighted networks, i.e. k-core analysis, recent works have introduced network decomposition methods that apply to weighted networks. Here, we investigate the relationship between k-core decomposition for unweighted networks and s-core decomposition for weighted networks by systematically employing a link-weight scheme that gradually discretizes the link weights. We applied this approach to the Erdős-Rényi model and the scale-free configuration model for five different weight distributions, and two empirical networks, the US air traffic network and a Facebook network. We find that (1) both uniformly random and positively correlated link-weight distributions give rise to highly stable s-core decompositions with respect to discretization levels. (2) For negatively correlated link-weight distributions, the resulting s-core decomposition has no similarity to the k-cores. Since several combinations of network topology and link-weight distributions give rise to a core-structure that is highly similar to the full s-core for a large range of link-discretization levels, it is possible to significantly speed up the numerical s-core analysis for these situations.

  4. Can Psychiatric Rehabilitation Be Core to CORE?

    ERIC Educational Resources Information Center

    Olney, Marjorie F.; Gill, Kenneth J.

    2016-01-01

    Purpose: In this article, we seek to determine whether psychiatric rehabilitation principles and practices have been more fully incorporated into the Council on Rehabilitation Education (CORE) standards, the extent to which they are covered in four rehabilitation counseling "foundations" textbooks, and how they are reflected in the…

  5. The fluffy core of Enceladus

    NASA Astrophysics Data System (ADS)

    Roberts, James H.

    2015-09-01

    Enceladus is well known for its young south polar terrain, observed by Cassini to emit several GW of heat as well as plumes of vapor and ice. The source of this energy is believed to be tidal dissipation. However, the observed south polar heat flux cannot be sustained over the age of the Solar System. Furthermore, thermal evolution models suggest that any global subsurface ocean should freeze on a timescale of tens to hundreds of My, sharply reducing future tidal heating, unless large amounts of antifreeze are present in the ocean. Here I propose an alternative internal structure for Enceladus, in which the silicate core is fragmented, and that the tidal deformation of the core may be partially controlled by interstitial ice. I find that fragmentation of the core increases tidal dissipation by a factor of 20, consistent with the long-term dynamically sustainable level, even when the interior is completely frozen, but only if the interior starts out warm and tidal heating is strong from the beginning. If this is not the case, radioactive heating will be insufficient to prevent the interior from cooling. Although an ocean need not be present in order for the interior to experience significant tidal heating, all models that dissipate enough heat to prevent runaway cooling are also warm enough to have an ocean. Tidal dissipation in the weak core provides an additional source of heat that may prevent a global subsurface ocean from freezing.

  6. Active Galaxy Winds from X-ray, Ultraviolet, and Optical Studies of Nearby Seyfert 1s

    NASA Astrophysics Data System (ADS)

    Winter, Lisa M.

    2012-01-01

    Mass outflows or winds from active galaxies may profoundly affect the evolution of their host galaxies by blowing away gas from star forming regions and recycling metals from near-nuclear supernovae into the galaxy disk. Such fundamental properties as the covering fraction, total energy, variability, and distance of these outflows are still unknown. We present new results in an effort to better understand the properties of active galaxy winds based on X-ray, optical, and UV observations of local Seyfert 1s. We show that the covering fraction, indicated through X-ray and optical spectroscopy, is higher than previous studies suggest. We also show new observations in the UV with the Hubble Space Telescope's Cosmic Origins Spectrograph (COS), showing that the UV variability is at a much lower level than X-ray variability. The COS observations also reveal weak Ly-alpha outflows, which were difficult/impossible to detect in previous generations of UV spectrographs.

  7. PBOV1 promotes prostate cancer proliferation by promoting G1/S transition

    PubMed Central

    Pan, Tiejun; Wu, Rongpei; Liu, Bo; Wen, Handong; Tu, Zhong; Guo, Jun; Yang, Jiarong; Shen, Guoqiu

    2016-01-01

    Prostate cancer (PC) is one of the leading causes of cancer death in men, and thus, finding new regulators is critical for PC therapy. Prostate and breast cancer overexpressed 1 (PBOV1) is overexpressed in breast, prostate, and bladder cancers, as it is upregulated in the serum of patients with PC, but the role of PBOV1 in PC has not been studied. In this article, we found that PBOV1 was indeed overexpressed in PC cells; PBOV1 overexpression promoted cell proliferation and colony formation ability and arrested cell cycle in the G0/G1 phase and tumorigenicity ability in vitro, whereas knockdown of PBOV1 reduced these effects. Further analysis of PBOV1 overexpression inhibited cell cycle inhibitors, P21 and P27, and increased the phosphorylation level of Rb and cyclin D1 expression, suggesting that PBOV1 promoted cell proliferation through promoting G1/S transition. PMID:26937201

  8. Making an Ice Core.

    ERIC Educational Resources Information Center

    Kopaska-Merkel, David C.

    1995-01-01

    Explains an activity in which students construct a simulated ice core. Materials required include only a freezer, food coloring, a bottle, and water. This hands-on exercise demonstrates how a glacier is formed, how ice cores are studied, and the nature of precision and accuracy in measurement. Suitable for grades three through eight. (Author/PVD)

  9. CORE - Performance Feedback System

    SciTech Connect

    2009-10-02

    CORE is an architecture to bridge the gaps between disparate data integration and delivery of disparate information visualization. The CORE Technology Program includes a suite of tools and user-centered staff that can facilitate rapid delivery of a deployable integrated information to users.

  10. Iowa Core Annual Report

    ERIC Educational Resources Information Center

    Iowa Department of Education, 2015

    2015-01-01

    One central component of a great school system is a clear set of expectations, or standards, that educators help all students reach. In Iowa, that effort is known as the Iowa Core. The Iowa Core represents the statewide academic standards, which describe what students should know and be able to do in math, science, English language arts, and…

  11. Ice Core Investigations

    ERIC Educational Resources Information Center

    Krim, Jessica; Brody, Michael

    2008-01-01

    What can glaciers tell us about volcanoes and atmospheric conditions? How does this information relate to our understanding of climate change? Ice Core Investigations is an original and innovative activity that explores these types of questions. It brings together popular science issues such as research, climate change, ice core drilling, and air…

  12. Modular core holder

    SciTech Connect

    Mueller, J.; Cole, C.W.; Hamid, S.; Lucas, J.K.

    1991-03-05

    This patent describes a modular core holder. It comprises: a sleeve, forming an internal cavity for receiving a core. The sleeve including segments; support means, overlying the sleeve, for supporting the sleeve; and access means, positioned between at least two of the segments of the sleeve, for allowing measurement of conditions within the internal cavity.

  13. Mercury's core evolution

    NASA Astrophysics Data System (ADS)

    Deproost, Marie-Hélène; Rivoldini, Attilio; Van Hoolst, Tim

    2016-10-01

    Remote sensing data of Mercury's surface by MESSENGER indicate that Mercury formed under reducing conditions. As a consequence, silicon is likely the main light element in the core together with a possible small fraction of sulfur. Compared to sulfur, which does almost not partition into solid iron at Mercury's core conditions and strongly decreases the melting temperature, silicon partitions almost equally well between solid and liquid iron and is not very effective at reducing the melting temperature of iron. Silicon as the major light element constituent instead of sulfur therefore implies a significantly higher core liquidus temperature and a decrease in the vigor of compositional convection generated by the release of light elements upon inner core formation.Due to the immiscibility in liquid Fe-Si-S at low pressure (below 15 GPa), the core might also not be homogeneous and consist of an inner S-poor Fe-Si core below a thinner Si-poor Fe-S layer. Here, we study the consequences of a silicon-rich core and the effect of the blanketing Fe-S layer on the thermal evolution of Mercury's core and on the generation of a magnetic field.

  14. NFE Core Bibliographies.

    ERIC Educational Resources Information Center

    Michigan State Univ., East Lansing. Inst. for International Studies in Education.

    This collection of core bibliographies, which expands on an initial bibliography published in 1979 of the core resources housed in the Non-Formal Education Information Center at Michigan State University, comprises a basic stock of materials on nonformal education and women in development that have been contributed by development planners,…

  15. Advocacy: Emphasizing the Uncommon about the Common Core State Standards

    ERIC Educational Resources Information Center

    Kaplan, Sandra N.

    2014-01-01

    The author describes key issues and uncommon concerns about the Common Core State Standards that fit within two categories: philosophical and pedagogical. Philosophically, Common Core State K-12 Standards should not be expected to be mastered at a specific grade level but based on developmental readiness. Pedagogically, Common Core State Standards…

  16. Internal core tightener

    DOEpatents

    Brynsvold, Glen V.; Snyder, Jr., Harold J.

    1976-06-22

    An internal core tightener which is a linear actuated (vertical actuation motion) expanding device utilizing a minimum of moving parts to perform the lateral tightening function. The key features are: (1) large contact areas to transmit loads during reactor operation; (2) actuation cam surfaces loaded only during clamping and unclamping operation; (3) separation of the parts and internal operation involved in the holding function from those involved in the actuation function; and (4) preloaded pads with compliant travel at each face of the hexagonal assembly at the two clamping planes to accommodate thermal expansion and irradiation induced swelling. The latter feature enables use of a "fixed" outer core boundary, and thus eliminates the uncertainty in gross core dimensions, and potential for rapid core reactivity changes as a result of core dimensional change.

  17. Lunar Core and Tides

    NASA Technical Reports Server (NTRS)

    Williams, J. G.; Boggs, D. H.; Ratcliff, J. T.

    2004-01-01

    Variations in rotation and orientation of the Moon are sensitive to solid-body tidal dissipation, dissipation due to relative motion at the fluid-core/solid-mantle boundary, and tidal Love number k2 [1,2]. There is weaker sensitivity to flattening of the core-mantle boundary (CMB) [2,3,4] and fluid core moment of inertia [1]. Accurate Lunar Laser Ranging (LLR) measurements of the distance from observatories on the Earth to four retroreflector arrays on the Moon are sensitive to lunar rotation and orientation variations and tidal displacements. Past solutions using the LLR data have given results for dissipation due to solid-body tides and fluid core [1] plus Love number [1-5]. Detection of CMB flattening, which in the past has been marginal but improving [3,4,5], now seems significant. Direct detection of the core moment has not yet been achieved.

  18. Radiation Effects: Core Project

    NASA Technical Reports Server (NTRS)

    Dicello, John F.

    1999-01-01

    The risks to personnel in space from the naturally occurring radiations are generally considered to be one of the most serious limitations to human space missions, as noted in two recent reports of the National Research Council/National Academy of Sciences. The Core Project of the Radiation Effects Team for the National Space Biomedical Research Institute is the consequences of radiations in space in order to develop countermeasure, both physical and pharmaceutical, to reduce the risks of cancer and other diseases associated with such exposures. During interplanetary missions, personnel in space will be exposed to galactic cosmic rays, including high-energy protons and energetic ions with atomic masses of iron or higher. In addition, solar events will produce radiation fields of high intensity for short but irregular durations. The level of intensity of these radiations is considerably higher than that on Earth's surface, and the biological risks to astronauts is consequently increased, including increased risks of carcinogenesis and other diseases. This group is examining the risk of cancers resulting from low-dose, low-dose rate exposures of model systems to photons, protons, and iron by using ground-based accelerators which are capable of producing beams of protons, iron, and other heavy ions at energies comparable to those encountered in space. They have begun the first series of experiments using a 1-GeV iron beam at the Brookhaven National Laboratory and 250-MeV protons at Loma Linda University Medical Center's proton synchrotron facility. As part of these studies, this group will be investigating the potential for the pharmaceutical, Tamoxifen, to reduce the risk of breast cancer in astronauts exposed to the level of doses and particle types expected in space. Theoretical studies are being carried out in a collaboration between scientists at NASA's Johnson Space Center and Johns Hopkins University in parallel with the experimental program have provided

  19. 34. DESPATCH CORE OVENS, GREY IRON FOUNDRY CORE ROOM, BAKES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. DESPATCH CORE OVENS, GREY IRON FOUNDRY CORE ROOM, BAKES CORES THAT ARE NOT MADE ON HEATED OR COLD BOX CORE MACHINES, TO SET BINDING AGENTS MIXED WITH THE SAND CREATING CORES HARD ENOUGH TO WITHSTAND THE FLOW OF MOLTEN IRON INSIDE A MOLD. - Stockham Pipe & Fittings Company, Grey Iron Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  20. Electron-hydrogen atom-impact 1s{yields}2s and 1s{yields}2p excitation with screened Coulomb interaction between the n=2 and n=3 excitation thresholds

    SciTech Connect

    Zhang Songbin; Chen Xiangjun; Wang Jianguo; Janev, R. K.

    2011-03-15

    The effects of Coulomb interaction screening on electron-hydrogen atom 1S {yields} 2S and 1S {yields} 2p excitation scattering between the n = 2 and n = 3 excitation thresholds have been investigated by using the R-matrix method with pseudostates. The excitation collision strengths show dramatic changes when the interaction screening length D varies from {infinity} to 9 a.u., as a result of the convergence of S-type and some p- and D-type Feshbach resonances to the varying 3S or 3p thresholds, and due to the crossover of some other p-, D- and all F-type Feshbach resonances into shape-type resonances when they pass across the 3S or 3p threshold at certain critical values of D. The noncrossover of some p- and D-type Feshbach resonances into shape-type resonances at the 3S (or 3p for those of D-type) threshold is at variance with the behavior of these types of resonances at the 2S (2p for those of D-type) threshold, which results from the threefold splitting of the n = 3 hydrogenic level and, consequently, the more complex nature of the configuration mixing in the n = 3 threshold region. The evolution of the total 1S {yields} 2S, 1S {yields} 2p, and 2S {yields} 2p excitation collision strengths, when the screening strength varies, is presented and discussed.

  1. Identification of multiple dmrt1s in catfish: localization, dimorphic expression pattern, changes during testicular cycle and after methyltestosterone treatment.

    PubMed

    Raghuveer, K; Senthilkumaran, B

    2009-05-01

    The double sex and mab-3 related (DM) transcription factor 1 (dmrt1) plays an important role in testicular differentiation. Here, we report cloning of multiple dmrt1s, a full-length and two alternative spliced forms from adult catfish (Clarias gariepinus) testis, which encode predicted proteins of 287 (dmrt1a), 253 (dmrt1b) and 233 (dmrt1c) amino acid residues respectively. Interestingly, dmrt1c lacks the majority of the DM domain. Multiple dmrt1s (dmrt1a and dmrt1c) were obtained from Clarias batrachus as well. Tissue distribution (transcript and protein) of catfish dmrt1 revealed exclusive expression in testis. Semi-quantitative RT-PCR revealed the presence of multiple dmrt1s with high levels of dmrt1a in adult testis but not in ovary. Real-time RT-PCR analysis during testicular cycle showed higher levels of dmrt1 transcripts in preparatory and pre-spawning when compared with spawning and post-spawning phases. Immunocytochemical and immunofluorescence localization revealed the presence of catfish Dmrt1 protein in spermatogonia and spermatocytes, which indicates plausible role in spermatogenesis. Histological analysis indicated initiation of gonadal sex differentiation in catfish around 40-50 days after hatching. The potential role for dmrt1 in testicular differentiation is evident from its stage-dependent elevated expression in developing testis. Furthermore, dimorphic expressions of dmrt1s were evident at different stages of gonadal development or recrudescence in catfish. Treatment of methyl testosterone (MT) during early stages of gonadal sex differentiation resulted in adult males. Interestingly, we also obtained MT-treated fishes having ova-testis gonads. Analysis of dmrt1, sox9a, foxl2 and cyp19a1 expression patterns in MT-treated gonads revealed tissue-specific pattern. These results together suggest that multiple dmrt1s are testis-specific markers in catfish.

  2. Multiple Core Galaxies

    NASA Technical Reports Server (NTRS)

    Miller, R.H.; Morrison, David (Technical Monitor)

    1994-01-01

    Nuclei of galaxies often show complicated density structures and perplexing kinematic signatures. In the past we have reported numerical experiments indicating a natural tendency for galaxies to show nuclei offset with respect to nearby isophotes and for the nucleus to have a radial velocity different from the galaxy's systemic velocity. Other experiments show normal mode oscillations in galaxies with large amplitudes. These oscillations do not damp appreciably over a Hubble time. The common thread running through all these is that galaxies often show evidence of ringing, bouncing, or sloshing around in unexpected ways, even though they have not been disturbed by any external event. Recent observational evidence shows yet another phenomenon indicating the dynamical complexity of central regions of galaxies: multiple cores (M31, Markarian 315 and 463 for example). These systems can hardly be static. We noted long-lived multiple core systems in galaxies in numerical experiments some years ago, and we have more recently followed up with a series of experiments on multiple core galaxies, starting with two cores. The relevant parameters are the energy in the orbiting clumps, their relative.masses, the (local) strength of the potential well representing the parent galaxy, and the number of cores. We have studied the dependence of the merger rates and the nature of the final merger product on these parameters. Individual cores survive much longer in stronger background potentials. Cores can survive for a substantial fraction of a Hubble time if they travel on reasonable orbits.

  3. Lateral restraint assembly for reactor core

    DOEpatents

    Gorholt, Wilhelm; Luci, Raymond K.

    1986-01-01

    A restraint assembly for use in restraining lateral movement of a reactor core relative to a reactor vessel wherein a plurality of restraint assemblies are interposed between the reactor core and the reactor vessel in circumferentially spaced relation about the core. Each lateral restraint assembly includes a face plate urged against the outer periphery of the core by a plurality of compression springs which enable radial preloading of outer reflector blocks about the core and resist low-level lateral motion of the core. A fixed radial key member cooperates with each face plate in a manner enabling vertical movement of the face plate relative to the key member but restraining movement of the face plate transverse to the key member in a plane transverse to the center axis of the core. In this manner, the key members which have their axes transverse to or subtending acute angles with the direction of a high energy force tending to move the core laterally relative to the reactor vessel restrain such lateral movement.

  4. Oscillator strengths for 1s2 1S0-1s2p 3P1,2 transitions in helium-like carbon, nitrogen and oxygen including the effects of a finite nuclear mass

    NASA Astrophysics Data System (ADS)

    Morton, Donald C.; Drake, G. W. F.

    2016-12-01

    We have calculated the electric dipole (E1) and magnetic quadrupole (M2) oscillator strengths and spontaneous decay rates for the 1{{{s}}}2{}1{{{S}}}0{--}1{{s}}2{{p}}{}3{{{P}}}{1,2} spin-changing transitions of helium-like C v, N vi and O vii. We added the effects of the finite nuclear mass and the anomalous magnetic moment of the electron including an extra term derived by Pachucki. For the E1 calculations we used the Breit approximation and pseudostate expansions to perform the perturbation sums over intermediate states in both the length and velocity gauge as a check on numerical accuracy and the validity of the transition operators. There is some cancellation in the corrections for the nuclear mass and the electron anomaly so that if one is included the other should not be ignored

  5. Lifetime of the 2/sup 1/S/sub 0/ state of heliumlike Ni/sup 26+/

    SciTech Connect

    Dunford, R.W.; Berry, H.G.; Groeneveld, K.O.; Hass, M.; Bakke, E.; Raphaelian, M.L.A.; Livingston, A.E.; Curtis, L.J.

    1988-11-15

    We report the observation of the two-photon decay of the 2/sup 1/S/sub 0/ level in heliumlike Ni/sup 26+/ and a measurement of the lifetime of this state. We find a lifetime of 150(16) ps, in agreement with the theoretical calculation of G. W. F. Drake (Phys. Rev. A 34, 2871 (1986)) which yields 154.3(5) ps.

  6. Global Core Plasma Model

    NASA Technical Reports Server (NTRS)

    Gallagher, Dennis L.; Craven, P. D.; Comfort, R. H.

    1999-01-01

    Abstract. The Global Core Plasma Model (GCPM) provides, empirically derived, core plasma density as a function of geomagnetic and solar conditions throughout the inner magnetosphere. It is continuous in value and gradient and is composed of separate models for the ionosphere, the plasmasphere, the plasmapause, the trough, and the polar cap. The relative composition of plasmaspheric H+, He+, and O+ is included in the GCPM. A blunt plasmaspheric bulge and rotation of the bulge with changing geomagnetic conditions is included. The GCPM is an amalgam of density models, intended to serve as a framework for continued improvement as new measurements become available and are used to characterize core plasma density, composition, and temperature.

  7. Core shroud corner joints

    DOEpatents

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  8. Measurement of exclusive Υ(1S) and Υ(2S) decays into vector-pseudoscalar final states

    NASA Astrophysics Data System (ADS)

    Shen, C. P.; Yuan, C. Z.; Adachi, I.; Aihara, H.; Asner, D. M.; Aulchenko, V.; Bakich, A. M.; Bala, A.; Bhuyan, B.; Bischofberger, M.; Bozek, A.; Bračko, M.; Browder, T. E.; Chekelian, V.; Chen, A.; Chen, P.; Cheon, B. G.; Chilikin, K.; Cho, I.-S.; Cho, K.; Chobanova, V.; Choi, Y.; Cinabro, D.; Dalseno, J.; Danilov, M.; Dingfelder, J.; Doležal, Z.; Drásal, Z.; Drutskoy, A.; Dutta, D.; Dutta, K.; Eidelman, S.; Epifanov, D.; Farhat, H.; Fast, J. E.; Ferber, T.; Frey, A.; Gaur, V.; Gabyshev, N.; Ganguly, S.; Gillard, R.; Goh, Y. M.; Golob, B.; Haba, J.; Hara, T.; Hayasaka, K.; Hayashii, H.; Hoshi, Y.; Hou, W.-S.; Hyun, H. J.; Iijima, T.; Ishikawa, A.; Itoh, R.; Iwasaki, Y.; Julius, T.; Kah, D. H.; Kang, J. H.; Kato, E.; Kawasaki, T.; Kiesling, C.; Kim, D. Y.; Kim, H. J.; Kim, J. B.; Kim, J. H.; Kim, K. T.; Kim, Y. J.; Kinoshita, K.; Klucar, J.; Ko, B. R.; Kodyš, P.; Korpar, S.; Križan, P.; Krokovny, P.; Kumita, T.; Kuzmin, A.; Kwon, Y.-J.; Lee, S.-H.; Leitner, R.; Li, J.; Li, Y.; Libby, J.; Liu, C.; Liu, Y.; Liu, Z. Q.; Liventsev, D.; Lukin, P.; Matvienko, D.; Miyabayashi, K.; Miyata, H.; Mohanty, G. B.; Moll, A.; Mori, T.; Muramatsu, N.; Mussa, R.; Nagasaka, Y.; Nakano, E.; Nakao, M.; Natkaniec, Z.; Nayak, M.; Nedelkovska, E.; Ng, C.; Nisar, N. K.; Nishida, S.; Nitoh, O.; Ogawa, S.; Okuno, S.; Olsen, S. L.; Ostrowicz, W.; Pakhlov, P.; Park, C. W.; Park, H.; Park, H. K.; Pedlar, T. K.; Peng, T.; Pestotnik, R.; Petrič, M.; Piilonen, L. E.; Ritter, M.; Röhrken, M.; Rostomyan, A.; Ryu, S.; Sahoo, H.; Saito, T.; Sakai, Y.; Sandilya, S.; Santelj, L.; Sanuki, T.; Sato, Y.; Savinov, V.; Schneider, O.; Schnell, G.; Schwanda, C.; Senyo, K.; Seon, O.; Shapkin, M.; Shebalin, V.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Sibidanov, A.; Simon, F.; Smerkol, P.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Stanič, S.; Starič, M.; Steder, M.; Sumihama, M.; Sumiyoshi, T.; Tamponi, U.; Tanida, K.; Tatishvili, G.; Teramoto, Y.; Tsuboyama, T.; Uchida, M.; Uehara, S.; Unno, Y.; Uno, S.; Urquijo, P.; Vahsen, S. E.; Van Hulse, C.; Vanhoefer, P.; Varner, G.; Vorobyev, V.; Wagner, M. N.; Wang, C. H.; Wang, P.; Wang, X. L.; Watanabe, M.; Watanabe, Y.; Won, E.; Yamamoto, H.; Yamaoka, J.; Yamashita, Y.; Yashchenko, S.; Yook, Y.; Yusa, Y.; Zhang, C. C.; Zhang, Z. P.; Zhilich, V.; Zupanc, A.

    2013-07-01

    Using samples of 102 million Υ(1S) and 158 million Υ(2S) events collected with the Belle detector, we study exclusive hadronic decays of these two bottomonium resonances to KS0K+π- and charge-conjugate (c.c.) states, π+π-π0π0, and π+π-π0, and to the two-body Vector-Pseudoscalar (K*(892)0K¯0+c.c., K*(892)-K++c.c., ωπ0, and ρπ) final states. For the first time, signals are observed in the modes Υ(1S)→KS0K+π-+c.c., π+π-π0π0, and Υ(2S)→π+π-π0π0, and evidence is found for the modes Υ(1S)→π+π-π0, K*(892)0K¯0+c.c., and Υ(2S)→KS0K+π-+c.c. Branching fractions are measured for all the processes, while 90% confidence level upper limits on the branching fractions are also set for the modes with a statistical significance of less than 3σ. The ratios of the branching fractions of Υ(2S) and Υ(1S) decays into the same final state are used to test a perturbative QCD prediction for Okubo-Zweig-Iizuka-suppressed bottomonium decays.

  9. Core assembly storage structure

    DOEpatents

    Jones, Jr., Charles E.; Brunings, Jay E.

    1988-01-01

    A structure for the storage of core assemblies from a liquid metal-cooled nuclear reactor. The structure comprises an enclosed housing having a substantially flat horizontal top plate, a bottom plate and substantially vertical wall members extending therebetween. A plurality of thimble members extend downwardly through the top plate. Each thimble member is closed at its bottom end and has an open end adjacent said top plate. Each thimble member has a length and diameter greater than that of the core assembly to be stored therein. The housing is provided with an inlet duct for the admission of cooling air and an exhaust duct for the discharge of air therefrom, such that when hot core assemblies are placed in the thimbles, the heat generated will by convection cause air to flow from the inlet duct around the thimbles and out the exhaust duct maintaining the core assemblies at a safe temperature without the necessity of auxiliary powered cooling equipment.

  10. Magnetorotational iron core collapse

    NASA Technical Reports Server (NTRS)

    Symbalisty, E. M. D.

    1984-01-01

    During its final evolutionary stages, a massive star, as considered in current astrophysical theory, undergoes rapid collapse, thereby triggering a sequence of a catastrophic event which results in a Type II supernova explosion. A remnant neutron star or a black hole is left after the explosion. Stellar collapse occurs, when thermonuclear fusion has consumed the lighter elements present. At this stage, the core consists of iron. Difficulties arise regarding an appropriate model with respect to the core collapse. The present investigation is concerned with the evolution of a Type II supernova core including the effects of rotation and magnetic fields. A simple neutrino model is developed which reproduced the spherically symmetric results of Bowers and Wilson (1982). Several two-dimensional computational models of stellar collapse are studied, taking into account a case in which a 15 solar masses iron core was artificially given rotational and magnetic energy.

  11. Contaminated Sediment Core Profiling

    EPA Science Inventory

    Evaluating the environmental risk of sites containing contaminated sediments often poses major challenges due in part to the absence of detailed information available for a given location. Sediment core profiling is often utilized during preliminary environmental investigations ...

  12. INTEGRAL core programme

    NASA Technical Reports Server (NTRS)

    Gehrels, N.; Schoenfelder, V.; Ubertini, P.; Winkler, C.

    1997-01-01

    The International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission is described with emphasis on the INTEGRAL core program. The progress made in the planning activities for the core program is reported on. The INTEGRAL mission has a nominal lifetime of two years with a five year extension option. The observing time will be divided between the core program (between 30 and 35 percent during the first two years) and general observations. The core program consists of three main elements: the deep survey of the Galactic plane in the central radian of the Galaxy; frequent scans of the Galactic plane in the search for transient sources, and pointed observations of several selected sources. The allocation of the observation time is detailed and the sensitivities of the observations are outlined.

  13. Biospecimen Core Resource - TCGA

    Cancer.gov

    The Cancer Genome Atlas (TCGA) Biospecimen Core Resource centralized laboratory reviews and processes blood and tissue samples and their associated data using optimized standard operating procedures for the entire TCGA Research Network.

  14. Observation of the Inclusive D^{* -} Production in the Decay of Y(1S)

    SciTech Connect

    Aubert, B.; Karyotakis, Y.; Lees, J.P.; Poireau, V.; Prencipe, E.; Prudent, X.; Tisserand, V.; Tico, J.Garra; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, D.N.; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G. /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, San Diego /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /Mt. Holyoke Coll. /INFN, Naples /Naples U. /INFN, Naples /INFN, Naples /Naples U. /NIKHEF, Amsterdam /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /Pennsylvania U. /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /Rome U. /INFN, Rome /Rome U. /Rome U. /INFN, Rome /Rome U. /INFN, Rome /Rome U. /Rome U. /INFN, Rome /Rome U. /INFN, Rome /Rome U. /Rome U. /INFN, Rome /Rome U. /INFN, Rome /Rome U. /Rome U. /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas Nuclear Corp., Austin /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2009-12-17

    The authors present a study of the inclusive D*{sup {+-}} production in the decay of {Upsilon}(1S) using (98.6 {+-} 0.9) x 10{sup 6} {Upsilon}(2S) mesons collected with the BABAR detector at the {Upsilon}(2S) resonance. Using the decay chain {Upsilon}(2S) {yields} {pi}{sup +}{pi}{sup -}{Upsilon}(1S), {Upsilon}(1S) {yields} D*{sup {+-}}X, where X is unobserved, they measure the branching fraction {Beta}[{Upsilon}(1S) {yields} D*{sup {+-}}X] = (2.52 {+-} 0.13(stat) {+-} 0.15(syst))% and the D*{sup {+-}} momentum distribution in the rest frame of the {Upsilon}(1S). They find evidence for an excess of D*{sup {+-}} production over the expected rate from the virtual photon annihilation process {Upsilon}(1S) {yields} {gamma}* {yields} c{bar c} {yields} D*{sup {+-}} X.

  15. Core bounce supernovae

    SciTech Connect

    Cooperstein, J.

    1987-01-01

    The gravitational collapse mechanism for Type II supernovae is considered, concentrating on the direct implosion - core bounce - hydrodynamic explosion picture. We examine the influence of the stiffness of the dense matter equation of state and discuss how the shock wave is formed. Its chances of success are determined by the equation of state, general relativistic effects, neutrino transport, and the size of presupernova iron core. 12 refs., 1 tab.

  16. Nuclear core positioning system

    DOEpatents

    Garkisch, Hans D.; Yant, Howard W.; Patterson, John F.

    1979-01-01

    A structural support system for the core of a nuclear reactor which achieves relatively restricted clearances at operating conditions and yet allows sufficient clearance between fuel assemblies at refueling temperatures. Axially displaced spacer pads having variable between pad spacing and a temperature compensated radial restraint system are utilized to maintain clearances between the fuel elements. The core support plates are constructed of metals specially chosen such that differential thermal expansion produces positive restraint at operating temperatures.

  17. Micro coring apparatus

    NASA Technical Reports Server (NTRS)

    Collins, David; Brooks, Marshall; Chen, Paul; Dwelle, Paul; Fischer, Ben

    1989-01-01

    A micro-coring apparatus for lunar exploration applications, that is compatible with the other components of the Walking Mobile Platform, was designed. The primary purpose of core sampling is to gain an understanding of the geological composition and properties of the prescribed environment. This procedure has been used extensively for Earth studies and in limited applications during lunar explorations. The corer is described and analyzed for effectiveness.

  18. MCNP LWR Core Generator

    SciTech Connect

    Fischer, Noah A.

    2012-08-14

    The reactor core input generator allows for MCNP input files to be tailored to design specifications and generated in seconds. Full reactor models can now easily be created by specifying a small set of parameters and generating an MCNP input for a full reactor core. Axial zoning of the core will allow for density variation in the fuel and moderator, with pin-by-pin fidelity, so that BWR cores can more accurately be modeled. LWR core work in progress: (1) Reflectivity option for specifying 1/4, 1/2, or full core simulation; (2) Axial zoning for moderator densities that vary with height; (3) Generating multiple types of assemblies for different fuel enrichments; and (4) Parameters for specifying BWR box walls. Fuel pin work in progress: (1) Radial and azimuthal zoning for generating further unique materials in fuel rods; (2) Options for specifying different types of fuel for MOX or multiple burn assemblies; (3) Additional options for replacing fuel rods with burnable poison rods; and (4) Control rod/blade modeling.

  19. Emergency core cooling system

    DOEpatents

    Schenewerk, William E.; Glasgow, Lyle E.

    1983-01-01

    A liquid metal cooled fast breeder reactor provided with an emergency core cooling system includes a reactor vessel which contains a reactor core comprising an array of fuel assemblies and a plurality of blanket assemblies. The reactor core is immersed in a pool of liquid metal coolant. The reactor also includes a primary coolant system comprising a pump and conduits for circulating liquid metal coolant to the reactor core and through the fuel and blanket assemblies of the core. A converging-diverging venturi nozzle with an intermediate throat section is provided in between the assemblies and the pump. The intermediate throat section of the nozzle is provided with at least one opening which is in fluid communication with the pool of liquid sodium. In normal operation, coolant flows from the pump through the nozzle to the assemblies with very little fluid flowing through the opening in the throat. However, when the pump is not running, residual heat in the core causes fluid from the pool to flow through the opening in the throat of the nozzle and outwardly through the nozzle to the assemblies, thus providing a means of removing decay heat.

  20. The ϒ(1S)→Bcρ decay with perturbative QCD approach

    NASA Astrophysics Data System (ADS)

    Sun, Junfeng; Yang, Yueling; Li, Qingxia; Lu, Gongru; Huang, Jinshu; Chang, Qin

    2016-08-01

    With the potential prospects of the ϒ (1 S) data samples at the running LHC and upcoming SuperKEKB, the ϒ (1 S) →Bc ρ weak decay is studied with the pQCD approach. It is found that (1) the lion's share of branching ratio comes from the longitudinal polarization helicity amplitudes; (2) branching ratio for the ϒ (1 S) →Bc ρ decay can reach up to O (10-9), which might be hopefully measurable.

  1. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

    PubMed

    Schepetkin, Igor A; Kirpotina, Liliya N; Hammaker, Deepa; Kochetkova, Irina; Khlebnikov, Andrei I; Lyakhov, Sergey A; Firestein, Gary S; Quinn, Mark T

    2015-06-01

    c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes, including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime) and demonstrated that it is a high-affinity JNK inhibitor and inhibits murine delayed-type hypersensitivity. Here we show that IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH. Molecular docking of the IQ-1S syn isomer into the JNK1 binding site gave the best pose, which corresponded to the position of cocrystallized JNK inhibitor SP600125 (1,9-pyrazoloanthrone). Evaluation of the therapeutic potential of IQ-1S showed that it inhibited matrix metalloproteinase 1 and 3 gene expression induced by interleukin-1β in human fibroblast-like synoviocytes and significantly attenuated development of murine collagen-induced arthritis (CIA). Treatment with IQ-1S either before or after induction of CIA resulted in decreased clinical scores, and joint sections from IQ-1S-treated CIA mice exhibited only mild signs of inflammation and minimal cartilage loss compared with those from control mice. Collagen II-specific antibody responses were also reduced by IQ-1S treatment. By contrast, the inactive ketone derivative 11H-indeno[1,2-b]quinoxalin-11-one had no effect on CIA clinical scores or collagen II-specific antibody titers. IQ-1S treatment also suppressed proinflammatory cytokine and chemokine levels in joints and lymph node cells. Finally, treatment with IQ-1S increased the number of Foxp3(+)CD4(+)CD25(+) regulatory T cells in lymph nodes. Thus, IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis.

  2. Search for a light Higgs resonance in radiative decays of the Y(1S) with a charm tag

    SciTech Connect

    Lees, J. P.

    2015-04-10

    In this study, a search is presented for the decay Υ(1S)→γA0, A0 → cc¯, where A0 is a candidate for the CP-odd Higgs boson of the next-to-minimal supersymmetric standard model. The search is based on data collected with the BABAR detector at the Υ(2S) resonance. A sample of Υ(1S) mesons is selected via the decay Υ(2S) → π+π Υ(1S). The A0 → cc¯ decay is identified through the reconstruction of hadronic D0, D+, and D*(2010)+ meson decays. No significant signal is observed. The measured 90% confidence-level upper limits on the product branching fraction B(Υ(1S) → γA0)×B(A0 → cc¯) range from 7.4×10–5 to 2.4×10–3 for A0 masses from 4.00 to 8.95 GeV/c2 and 9.10 to 9.25 GeV/c2, where the region between 8.95 and 9.10 GeV/c2 is excluded because of background from Υ(2S) → γχbJ(1P), χbJ(1P) → γΥ(1S) decays.

  3. Three-Loop Slope of the Dirac Form Factor and the 1S Lamb Shift in Hydrogen

    SciTech Connect

    Melnikov, Kirill; Ritbergen, Timo van

    2000-02-21

    The last unknown contribution to hydrogen energy levels at order m{alpha}{sup 7} , due to the slope of the Dirac form factor at three loops, is evaluated in a closed analytical form. The resulting shift of the hydrogen nS energy level is found to be 3.016/n{sup 3} kHz . Using the QED calculations of the 1S Lamb shift, we extract a precise value of the proton charge radius r{sub p}=0.883{+-}0.014 fm . (c) 2000 The American Physical Society.

  4. Three-Loop Slope of the Dirac Form Factor and the 1S Lamb Shift in Hydrogen.

    PubMed

    Melnikov, K; van Ritbergen, T

    2000-02-21

    The last unknown contribution to hydrogen energy levels at order mα^{7}, due to the slope of the Dirac form factor at three loops, is evaluated in a closed analytical form. The resulting shift of the hydrogen nS energy level is found to be 3.016/n^{3} kHz. Using the QED calculations of the 1S Lamb shift, we extract a precise value of the proton charge radius r_{p}=0.883±0.014 fm.

  5. Double-slit experiment with a polyatomic molecule: vibrationally resolved C 1s photoelectron spectra of acetylene

    NASA Astrophysics Data System (ADS)

    Argenti, L.; Thomas, T. D.; Plésiat, E.; Liu, X.-J.; Miron, C.; Lischke, T.; Prümper, G.; Sakai, K.; Ouchi, T.; Püttner, R.; Sekushin, V.; Tanaka, T.; Hoshino, M.; Tanaka, H.; Decleva, P.; Ueda, K.; Martín, F.

    2012-03-01

    We report the first evidence for double-slit interferences in a polyatomic molecule, which we have observed in the experimental carbon 1s photoelectron spectra of acetylene (or ethyne). The spectra have been measured over the photon energy range of 310-930 eV and show prominent oscillations in the intensity ratios σg(υ)/σu(υ) for the vibrational quantum numbers υ = 0,1 and for the ratios σs(υ = 1)/σs(υ = 0) for the symmetry s = g,u. The experimental findings are in very good agreement with ab initio density functional theory (DFT) calculations and are compatible with the Cohen-Fano mechanism of coherent emission from two equivalent atomic centers. This interpretation is supported by the qualitative predictions of a simple model in which the effect of nuclear recoil is taken into account to the lowest order. Our results confirm the delocalized character of the core hole created in the primary photoionization event and demonstrate that intramolecular core-hole coherence can survive the decoherent influence associated with the asymmetric nuclear degrees of freedom which are characteristic of polyatomic molecules.

  6. Time-resolved soft X-ray core-level photoemission spectroscopy at 880 °C using the pulsed laser and synchrotron radiation and the pulse heating current

    NASA Astrophysics Data System (ADS)

    Abukawa, T.; Yamamoto, S.; Yukawa, R.; Kanzaki, S.; Mukojima, K.; Matsuda, I.

    2017-02-01

    We developed a time-resolved photoemission spectroscopy system for tracking the temporal variation in an electronic state of a heated sample. Our pump-probe method used laser and synchrotron radiation pulses on a silicon surface that was heated by a synchronized pulse current that did not interfere with the measurements. The transient surface photovoltage effect on the Si 2p core spectra was measured from room temperature to 880 °C and was found to be consistent with the thermal carrier distributions in silicon crystals at the corresponding temperatures. This versatile technique may have applications studying molecular dynamics on high temperature surfaces such as in catalytic reactions.

  7. (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

    PubMed Central

    Kozhushkov, Sergei I; Yufit, Dmitrii S; Grosse, Christian; Kaiser, Marcel

    2014-01-01

    Summary Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a–c, as well as allo-D-threonine (4) and (2S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S)- and (R)-2-[(N-benzylprolyl)amino]benzophenone [(S)- and (R)-10] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin (1) with (fluoromethylcyclopropyl)alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity. PMID:25550751

  8. Recent developments in pressure coring

    SciTech Connect

    McFall, A. L.

    1980-01-01

    The current rapid growth in the number of enhanced oil and gas recovery projects has created a strong demand for reservoir data such as true residual oil saturations. The companies providing pressure coring services have moved to fill this need. Two recent developments have emerged with the potential of significantly improving the present performance of pressure coring. Coring bits utilizing synthetic diamond cutters have demonstrated coring rates of one-foot per minute while improving core recovery. It is also apparent that cores of a near-unconsolidated nature are more easily recovered. In addition, a special low invasion fluid that is placed in the core retriever has demonstrated reduced core washing by the drilling mud and a decrease in the complexity of preparing cores for analysis. This paper describes the design, laboratory, and field testing efforts that led to these coring improvements. Also, experience in utilizing these developments while recovering over 100 cores is discussed.

  9. Pressure Core Characterization

    NASA Astrophysics Data System (ADS)

    Santamarina, J. C.

    2014-12-01

    Natural gas hydrates form under high fluid pressure and low temperature, and are found in permafrost, deep lakes or ocean sediments. Hydrate dissociation by depressurization and/or heating is accompanied by a multifold hydrate volume expansion and host sediments with low permeability experience massive destructuration. Proper characterization requires coring, recovery, manipulation and testing under P-T conditions within the stability field. Pressure core technology allows for the reliable characterization of hydrate bearing sediments within the stability field in order to address scientific and engineering needs, including the measurement of parameters used in hydro-thermo-mechanical analyses, and the monitoring of hydrate dissociation under controlled pressure, temperature, effective stress and chemical conditions. Inherent sampling effects remain and need to be addressed in test protocols and data interpretation. Pressure core technology has been deployed to study hydrate bearing sediments at several locations around the world. In addition to pressure core testing, a comprehensive characterization program should include sediment analysis, testing of reconstituted specimens (with and without synthetic hydrate), and in situ testing. Pressure core characterization technology can be used to study other gas-charged formations such as deep sea sediments, coal bed methane and gas shales.

  10. GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

    PubMed Central

    Maroz, Aliaksandra; Stachorski, Lena; Emmrich, Stephan; Reinhardt, Katarina; Xu, Jian; Shao, Zhen; Käbler, Sebastian; Dertmann, Tobias; Hitzler, Johann; Roberts, Irene; Vyas, Paresh; Juban, Gaetan; Hennig, Christian; Hansen, Gesine; Li, Zhe; Orkin, Stuart; Reinhardt, Dirk; Klusmann, Jan-Henning

    2014-01-01

    Transient leukemia (TL) is evident in 5–10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we report that TL cell clones generate abundant eosinophils in a substantial fraction of patients. Sorted eosinophils from patients with TL and eosinophilia carried the same GATA1s-mutation as sorted TL-blasts, consistent with their clonal origin. TL-blasts exhibited a genetic program characteristic of eosinophils and differentiated along the eosinophil lineage in vitro. Similarly, ectopic expression of Gata1s, but not Gata1, in wild-type CD34+-hematopoietic stem and progenitor cells induced hyperproliferation of eosinophil promyelocytes in vitro. While GATA1s retained the function of GATA1 to induce eosinophil genes by occupying their promoter regions, GATA1s was impaired in its ability to repress oncogenic MYC and the pro-proliferative E2F transcription network. ChIP-seq indicated reduced GATA1s occupancy at the MYC promoter. Knockdown of MYC, or the obligate E2F-cooperation partner DP1, rescued the GATA1s-induced hyperproliferative phenotype. In agreement, terminal eosinophil maturation was blocked in Gata1Δe2 knockin mice, exclusively expressing Gata1s, leading to accumulation of eosinophil precursors in blood and bone marrow. These data suggest a direct relationship between the N-terminal truncating mutations of GATA1 and clonal eosinophilia in DS patients. PMID:24336126

  11. Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.

    PubMed

    Yue, Fei; Li, Wenjiao; Zou, Jing; Chen, Qi; Xu, Guibin; Huang, Hai; Xu, Zhen; Zhang, Sheng; Gallinari, Paola; Wang, Fen; McKeehan, Wallace L; Liu, Leyuan

    2015-10-01

    Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes with it in cytosolic inclusions. It was suggested HDAC4 interacts with MAP1S in a yeast two-hybrid screening. Here, we found that MAP1S interacts with HDAC4 via a HDAC4-binding domain (HBD). HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates. This occurs by an increase in the deacetylation of the acetylated MAP1S. Either suppression of HDAC4 with siRNA or overexpression of the MAP1S HBD leads to stabilization of MAP1S, activation of autophagy flux and clearance of mHTT aggregates. Therefore, specific interruption of the HDAC4-MAP1S interaction with short peptides or small molecules to enhance autophagy flux may relieve the toxicity of mHTT associated with Huntington's disease and improve symptoms of HD patients.

  12. The Theory of Dense Core Collapse

    NASA Astrophysics Data System (ADS)

    Li, Zhi-Yun

    2014-07-01

    I will review the theory of dense core collapse, with an emphasis on disk formation. Disk formation, once thought to be a simple consequence of the conservation of angular momentum during hydrodynamic core collapse, is far more subtle in magnetized gas. In this case, rotation can be strongly magnetically braked. Indeed, both analytic arguments and numerical simulations have shown that disk formation is suppressed in ideal MHD at the observed level of core magnetization. I will discuss the physical reason for this so-called “magnetic braking catastrophe,” and review possible resolutions to the problem that have been proposed so far, including non-ideal MHD effects, misalignment between the magnetic field and rotation axis, and turbulence. Other aspects of core collapse, such as fragmentation and outflow generation, will also be discussed.

  13. {upsilon}(1S){yields}{gamma}f{sub 2}(1270) decay

    SciTech Connect

    Li Bingan

    2009-12-01

    Decay {upsilon}(1S){yields}{gamma}f{sub 2}(1270) is studied by an approach in which the tensor meson, f{sub 2}(1270), is strongly coupled to gluons. Besides the strong suppression of the amplitude {upsilon}(1S){yields}{gamma}gg, gg{yields}f{sub 2} by the mass of the b-quark, d-wave dominance in {upsilon}(1S){yields}{gamma}f{sub 2}(1270) is revealed from this approach, which provides a large enhancement. The combination of these two factors leads to larger B({upsilon}(1S){yields}{gamma}f{sub 2}(1270)). The decay rate of {upsilon}(1S){yields}{gamma}f{sub 2}(1270) and the ratios of the helicity amplitudes are obtained and they are in agreement with the data.

  14. Molten core retention assembly

    DOEpatents

    Lampe, Robert F.

    1976-06-22

    Molten fuel produced in a core overheating accident is caught by a molten core retention assembly consisting of a horizontal baffle plate having a plurality of openings therein, heat exchange tubes having flow holes near the top thereof mounted in the openings, and a cylindrical, imperforate baffle attached to the plate and surrounding the tubes. The baffle assembly is supported from the core support plate of the reactor by a plurality of hanger rods which are welded to radial beams passing under the baffle plate and intermittently welded thereto. Preferably the upper end of the cylindrical baffle terminates in an outwardly facing lip to which are welded a plurality of bearings having slots therein adapted to accept the hanger rods.

  15. Earth's core iron

    NASA Astrophysics Data System (ADS)

    Geophysicist J. Michael Brown of Texas A & M University noted recently at the Spring AGU Meeting in Baltimore that the structure and phase of metallic iron at pressures of the earth's inner core (approximately 3.3 Mbar) could have great significance in defining geometrical aspects of the core itself. Brown worked at the Los Alamos Scientific Laboratory with R.B. McQueen to redetermine the phase relations of metallic iron in a series of new shock-wave experiments. They found the melting point of iron at conditions equal to those at the boundary of the earth's outer (liquid) and inner (solid) cores to be 6000°±500°C (Geophysical Research Letters, 7, 533-536, 1980).

  16. The novel function of JADE1S in cytokinesis of epithelial cells

    PubMed Central

    Siriwardana, Nirodhini S; Meyer, Rosana D; Panchenko, Maria V

    2015-01-01

    JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling and phosphorylation during G2/M to G1 transition, which was sensitive to Aurora A inhibition. In the current study we examined mechanisms of the cell cycle regulation by the small isoform of JADE1 protein, JADE1S, and report data showing that JADE1S has a novel function in the regulation of cytokinesis. Using FACS assays, we show that, JADE1S depletion facilitated rates of G1-cells accumulation in synchronously dividing HeLa cell cultures. Depletion of JADE1S protein in asynchronously dividing cells decreased the proportion of cytokinetic cells, and increased the proportion of multi-nuclear cells, indicative of premature and failed cytokinesis. In contrast, moderate overexpression of JADE1S increased the number of cytokinetic cells in time- and dose- dependent manner, indicating cytokinetic delay. Pharmacological inhibition of Aurora B kinase resulted in the release of JADE1S-mediated cytokinetic delay and allowed progression of abscission in cells over-expressing JADE1S. Finally, we show that JADE1S protein localized to centrosomes in interphase and mitotic cells, while during cytokinesis JADE1S localized to the midbody. Neither JADE1L nor partner of JADE1, HAT HBO1 was localized to the centrosomes or midbodies. Our study identifies the novel role for JADE1S in regulation of cytokinesis and suggests function in Aurora B kinase-mediated cytokinesis checkpoint. PMID:26151225

  17. Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein

    SciTech Connect

    Kashuba, Elena . E-mail: Elena.Kashuba@mtc.ki.se; Yurchenko, Mariya; Szirak, Krisztina; Stahl, Joachim; Klein, George; Szekely, Laszlo

    2005-02-01

    Epstein-Barr virus (EBV) transforms resting human B cells into immortalized immunoblasts. EBV-encoded nuclear antigens EBNA-5 (also called EBNA-LP) is one of the earliest viral proteins expressed in freshly infected B cells. We have recently shown that EBNA-5 binds p14ARF, a nucleolar protein that regulates the p53 pathway. Here, we report the identification of another protein with partially nucleolar localization, the v-fos transformation effector Fte-1 (Fte-1/S3a), as an EBNA-5 binding partner. In transfected cells, Fte-1/S3a and EBNA-5 proteins showed high levels of colocalization in extranucleolar inclusions. Fte-1/S3a has multiple biological functions. It enhances v-fos-mediated cellular transformation and is part of the small ribosomal subunit. It also interacts with the transcriptional factor CHOP and apoptosis regulator poly(ADP-ribose) polymerase (PARP). Fte-1/S3a is regularly expressed at high levels in both tumors and cancer cell lines. Its high expression favors the maintenance of malignant phenotype and undifferentiated state, whereas its down-regulation is associated with cellular differentiation and growth arrest. Here, we show that EBV-induced B cell transformation leads to the up-regulation of Fte-1/S3a. We suggest that EBNA-5 through binding may influence the growth promoting, differentiation inhibiting, or apoptosis regulating functions of Fte-1/S3a.

  18. 1s22p3 and 1s22s23l, l = s,p,d, excited states of boron isoelectronic series from explicitly correlated wave functions.

    PubMed

    Gálvez, F J; Buendía, E; Sarsa, A

    2005-07-15

    For some members of the boron isoelectronic series and starting from explicitly correlated wave functions, six low-lying excited states have been studied. Three of them arise from the 1s(2)2p(3) configuration, and the other three from the 1s(2)2s(2)3l, l = s,p,d, configurations. This work follows a previous one on both the 1s(2)2s(2)2p-(2)P ground state and the four excited states coming from the 1s(2)2s2p(2) configuration. Energies, one- and two-body densities in position space and some other two-body properties in position and momentum spaces have been obtained. A systematic analysis of the energetic ordering of the states as a function of the total orbital angular momentum and spin is performed in terms of the electron-nucleus and electron-electron potential energies and the role of the angular correlation is discussed. All calculations have been carried out by using the Monte Carlo algorithm.

  19. Determination of the de-excitation probability of argon metastable (1s5 and 1s3) atoms on aluminum, stainless steel, silicon, quartz and Pyrex surfaces

    NASA Astrophysics Data System (ADS)

    Wang, Zhen-Bin; Li, Jiang-Tao; Zhu, Xi-Ming; Pu, Yi-Kang

    2015-03-01

    The de-excitation probability of argon 1s5 and 1s3 metastable atoms on aluminum (alloy 2024), stainless steel (304), silicon (100), quartz (JGS1) and Pyrex surfaces is measured with a low pressure (1-5 mTorr) pulsed capacitively coupled plasma. The de-excitation probability is deduced from the loss rate of the metastable atoms in the late afterglow, which is obtained from the temporal evolution of the metastable atom density measured by laser absorption. Under the low pressure condition, the loss of the metastable atoms is mainly due to volume diffusion and de-excitation on the surface. The measured de-excitation probability for both Ar*(1s5) and Ar*(1s3) atoms ranges from 0.74 to 0.88 on these five materials, with an uncertainty of ±0.11. The measured probabilities on the Pyrex surface are in good agreement with those reported in previous work, and those on aluminum, stainless steel, silicon and quartz surfaces are reported here for the first time.

  20. Oak Ridge National Laboratory Core Competencies

    SciTech Connect

    Roberto, J.B.; Anderson, T.D.; Berven, B.A.; Hildebrand, S.G.; Hartman, F.C.; Honea, R.B.; Jones, J.E. Jr.; Moon, R.M. Jr.; Saltmarsh, M.J.; Shelton, R.B.

    1994-12-01

    A core competency is a distinguishing integration of capabilities which enables an organization to deliver mission results. Core competencies represent the collective learning of an organization and provide the capacity to perform present and future missions. Core competencies are distinguishing characteristics which offer comparative advantage and are difficult to reproduce. They exhibit customer focus, mission relevance, and vertical integration from research through applications. They are demonstrable by metrics such as level of investment, uniqueness of facilities and expertise, and national impact. The Oak Ridge National Laboratory (ORNL) has identified four core competencies which satisfy the above criteria. Each core competency represents an annual investment of at least $100M and is characterized by an integration of Laboratory technical foundations in physical, chemical, and materials sciences; biological, environmental, and social sciences; engineering sciences; and computational sciences and informatics. The ability to integrate broad technical foundations to develop and sustain core competencies in support of national R&D goals is a distinguishing strength of the national laboratories. The ORNL core competencies are: 9 Energy Production and End-Use Technologies o Biological and Environmental Sciences and Technology o Advanced Materials Synthesis, Processing, and Characterization & Neutron-Based Science and Technology. The distinguishing characteristics of each ORNL core competency are described. In addition, written material is provided for two emerging competencies: Manufacturing Technologies and Computational Science and Advanced Computing. Distinguishing institutional competencies in the Development and Operation of National Research Facilities, R&D Integration and Partnerships, Technology Transfer, and Science Education are also described. Finally, financial data for the ORNL core competencies are summarized in the appendices.

  1. Search for a light Higgs boson decaying to two gluons or ss̄ in the radiative decays of Υ(1S)

    DOE PAGES

    Lees, J. P.; Poireau, V.; Tisserand, V.; ...

    2013-08-06

    We search for the decay Υ(1S)→γA⁰, A⁰→gg or ss̄, where A⁰ is the pseudoscalar light Higgs boson predicted by the next-to-minimal supersymmetric Standard Model. We use a sample of (17.6±0.3)×10⁶ Υ(1S) mesons produced in the BABAR experiment via e⁺e⁻→Υ(2S)→π⁺π⁻Υ(1S). We see no significant signal and set 90%-confidence-level upper limits on the product branching fraction B(Υ(1S)→γA⁰)·B(A⁰→gg or ss̄) ranging from 10⁻⁶ to 10⁻² for A⁰ masses in the range 0.5–9.0 GeV/c².

  2. High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

    PubMed

    van der Laan, Siem; Tsanov, Nikolay; Crozet, Carole; Maiorano, Domenico

    2013-11-07

    The molecular mechanism underlying G1/S checkpoint bypass in mouse embryonic stem cells (ESCs) remains unknown. DNA damage blocks S phase entry by inhibiting the CDK2 kinase through destruction of its activator, the Cdc25A phosphatase. We observed high Cdc25A levels in G1 that persist even after DNA damage in mouse ESCs. We also found higher expression of Dub3, a deubiquitylase that controls Cdc25A protein abundance. Moreover, we demonstrate that the Dub3 gene is a direct target of Esrrb, a key transcription factor of the self-renewal machinery. We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A destabilization, while forced Dub3 expression in ESCs becomes lethal upon differentiation, concomitant to cell-cycle remodeling and lineage commitment. Finally, knockdown of either Dub3 or Cdc25A induced spontaneous differentiation of ESCs. Altogether, these findings couple the self-renewal machinery to cell-cycle control through a deubiquitylase in ESCs.

  3. Benchmark Evaluation of the NRAD Reactor LEU Core Startup Measurements

    SciTech Connect

    J. D. Bess; T. L. Maddock; M. A. Marshall

    2011-09-01

    The Neutron Radiography (NRAD) reactor is a 250-kW TRIGA-(Training, Research, Isotope Production, General Atomics)-conversion-type reactor at the Idaho National Laboratory; it is primarily used for neutron radiography analysis of irradiated and unirradiated fuels and materials. The NRAD reactor was converted from HEU to LEU fuel with 60 fuel elements and brought critical on March 31, 2010. This configuration of the NRAD reactor has been evaluated as an acceptable benchmark experiment and is available in the 2011 editions of the International Handbook of Evaluated Criticality Safety Benchmark Experiments (ICSBEP Handbook) and the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Significant effort went into precisely characterizing all aspects of the reactor core dimensions and material properties; detailed analyses of reactor parameters minimized experimental uncertainties. The largest contributors to the total benchmark uncertainty were the 234U, 236U, Er, and Hf content in the fuel; the manganese content in the stainless steel cladding; and the unknown level of water saturation in the graphite reflector blocks. A simplified benchmark model of the NRAD reactor was prepared with a keff of 1.0012 {+-} 0.0029 (1s). Monte Carlo calculations with MCNP5 and KENO-VI and various neutron cross section libraries were performed and compared with the benchmark eigenvalue for the 60-fuel-element core configuration; all calculated eigenvalues are between 0.3 and 0.8% greater than the benchmark value. Benchmark evaluations of the NRAD reactor are beneficial in understanding biases and uncertainties affecting criticality safety analyses of storage, handling, or transportation applications with LEU-Er-Zr-H fuel.

  4. Measurement of the 1S-2S Frequency in Atomic Hydrogen

    NASA Astrophysics Data System (ADS)

    Hildum, Edward Ames

    A first precise measurement of the 1S-2S energy interval in atomic hydrogen has been obtained by observing the 1S-2S transition in an atomic beam by pulsed Doppler -free two-photon spectroscopy and using an interferometrically calibrated line of ('130)Te(,2) at 486 nm as the reference. The measured 1S-2S frequency is 2 466 061 395.6(4.9) MHz. With the calculated 1S Lamb shift, the 1S-2S frequency yields a value for the Rydberg constant, R(,(INFIN)) = 109 737.314 92(22) cm('-1), which is not in good agreement with the most recent previously measured value, 109 737.315 44(11) cm('-1), obtained by S. R. Amin et al.('16) It is, however, in good agreement with a previous Rydberg value, 109 737.315 04(32) cm('-1), measured by J. E. M. Goldsmith('17). If the Rydberg constant is taken as given, the 1S-2S frequency determines a value for the 1S Lamb shift. With Amin's Rydberg, the measured Lamb shift is 8161.0(5.4) MHz, in poor agreement with the theoretical value of 8149.43(8) MHz. With Goldsmith's Rydberg, the measured Lamb shift is 8151.0(8.7) MHz, in good agreement with theory.

  5. Navagating the Common Core

    ERIC Educational Resources Information Center

    McShane, Michael Q.

    2014-01-01

    This article presents a debate over the Common Core State Standards Initiative as it has rocketed to the forefront of education policy discussions around the country. The author contends that there is value in having clear cross state standards that will clarify the new online and blended learning that the growing use of technology has provided…

  6. Ultrasonic Drilling and Coring

    NASA Technical Reports Server (NTRS)

    Bar-Cohen, Yoseph

    1998-01-01

    A novel drilling and coring device, driven by a combination, of sonic and ultrasonic vibration, was developed. The device is applicable to soft and hard objects using low axial load and potentially operational under extreme conditions. The device has numerous potential planetary applications. Significant potential for commercialization in construction, demining, drilling and medical technologies.

  7. NUCLEAR REACTOR CORE DESIGN

    DOEpatents

    Mahlmeister, J.E.; Peck, W.S.; Haberer, W.V.; Williams, A.C.

    1960-03-22

    An improved core design for a sodium-cooled, graphitemoderated nuclear reactor is described. The improved reactor core comprises a number of blocks of moderator material, each block being in the shape of a regular prism. A number of channels, extending the length of each block, are disposed around the periphery. When several blocks are placed in contact to form the reactor core, the channels in adjacent blocks correspond with each other to form closed conduits extending the length of the core. Fuel element clusters are disposed in these closed conduits, and liquid coolant is forced through the annulus between the fuel cluster and the inner surface of the conduit. In a preferred embodiment of the invention, the moderator blocks are in the form of hexagonal prisms with longitudinal channels cut into the corners of the hexagon. The main advantage of an "edge-loaded" moderator block is that fewer thermal neutrons are absorbed by the moderator cladding, as compared with a conventional centrally loaded moderator block.

  8. Authentic to the Core

    ERIC Educational Resources Information Center

    Kukral, Nicole; Spector, Stacy

    2012-01-01

    When educators think about what makes learning relevant to students, often they narrow their thinking to electives or career technical education. While these provide powerful opportunities for students to make relevant connections to their learning, they can also create authentic experiences in the core curriculum. In the San Juan Unified School…

  9. Electromagnetic pump stator core

    DOEpatents

    Fanning, Alan W.; Olich, Eugene E.; Dahl, Leslie R.

    1995-01-01

    A stator core for supporting an electrical coil includes a plurality of groups of circumferentially abutting flat laminations which collectively form a bore and perimeter. A plurality of wedges are interposed between the groups, with each wedge having an inner edge and a thicker outer edge. The wedge outer edges abut adjacent ones of the groups to provide a continuous path around the perimeter.

  10. Theory of core excitons

    SciTech Connect

    Dow, J. D.; Hjalmarson, H. P.; Sankey, O. F.; Allen, R. E.; Buettner, H.

    1980-01-01

    The observation of core excitons with binding energies much larger than those of the valence excitons in the same material has posed a long-standing theoretical problem. A proposed solution to this problem is presented, and Frenkel excitons and Wannier excitons are shown to coexist naturally in a single material. (GHT)

  11. Some Core Contested Concepts

    ERIC Educational Resources Information Center

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…

  12. Core Directions in HRD.

    ERIC Educational Resources Information Center

    1996

    This document consists of four papers presented at a symposium on core directions in human resource development (HRD) moderated by Verna Willis at the 1996 conference of the Academy of Human Resource Development. "Reengineering the Organizational HRD Function: Two Case Studies" (Neal Chalofsky) reports an action research study in which…

  13. Core Geometry Manual.

    ERIC Educational Resources Information Center

    Hirata, Li Ann

    Core Geometry is a course offered in the Option Y sequence of the high school mathematics program described by the Hawaii State Department of Education's guidelines. The emphasis of this course is on the general awareness and use of the relationships among points, lines, and figures in planes and space. This sample course is based on the…

  14. Life from the core

    NASA Astrophysics Data System (ADS)

    Doglioni, Carlo; Coleman, Max; Pignatti, Johannes; Glassmeier, Karl-Heinz

    2010-05-01

    Life on Earth is the result of the chaotic combination of several independent chemical and physical parameters. One of them is the shield from ionizing radiation exerted by the atmosphere and the Earth's magnetic field. We hypothesise that the first few billion years of the Earth's history, dominated by bacteria, were characterized by stronger ionizing radiation. Bacteria can survive under such conditions better than any other organism. During the Archean and early Proterozoic the shield could have been weaker, allowing the development of only a limited number of species, more resistant to the external radiation. The Cambrian explosion of life could have been enhanced by the gradual growth of the solid inner core, which was not existent possibly before 1 Ga. The cooling of the Earth generated the solidification of the iron alloy in the center of the planet. As an hypothesis, before the crystallization of the core, the turbulence in the liquid core could have resulted in a lower or different magnetic field from the one we know today, being absent the relative rotation between inner and external core.

  15. The Earth's Core.

    ERIC Educational Resources Information Center

    Jeanloz, Raymond

    1983-01-01

    The nature of the earth's core is described. Indirect evidence (such as that determined from seismological data) indicates that it is an iron alloy, solid toward its center but otherwise liquid. Evidence also suggests that it is the turbulent flow of the liquid that generates the earth's magnetic field. (JN)

  16. Modeling Core Collapse Supernovae

    NASA Astrophysics Data System (ADS)

    Mezzacappa, Anthony

    2017-01-01

    Core collapse supernovae, or the death throes of massive stars, are general relativistic, neutrino-magneto-hydrodynamic events. The core collapse supernova mechanism is still not in hand, though key components have been illuminated, and the potential for multiple mechanisms for different progenitors exists. Core collapse supernovae are the single most important source of elements in the Universe, and serve other critical roles in galactic chemical and thermal evolution, the birth of neutron stars, pulsars, and stellar mass black holes, the production of a subclass of gamma-ray bursts, and as potential cosmic laboratories for fundamental nuclear and particle physics. Given this, the so called ``supernova problem'' is one of the most important unsolved problems in astrophysics. It has been fifty years since the first numerical simulations of core collapse supernovae were performed. Progress in the past decade, and especially within the past five years, has been exponential, yet much work remains. Spherically symmetric simulations over nearly four decades laid the foundation for this progress. Two-dimensional modeling that assumes axial symmetry is maturing. And three-dimensional modeling, while in its infancy, has begun in earnest. I will present some of the recent work from the ``Oak Ridge'' group, and will discuss this work in the context of the broader work by other researchers in the field. I will then point to future requirements and challenges. Connections with other experimental, observational, and theoretical efforts will be discussed, as well.

  17. University City Core Plan.

    ERIC Educational Resources Information Center

    Philadelphia City Planning Commission, PA.

    A redevelopment plan for an urban core area of about 300 acres was warranted by--(1) unsuitable building conditions, (2) undesirable land usage, and (3) faulty traffic circulation. The plan includes expansion of two universities and creation of a regional science center, high school, and medical center. Guidelines for proposed land use and zoning…

  18. The Tom Core Complex

    PubMed Central

    Ahting, Uwe; Thun, Clemens; Hegerl, Reiner; Typke, Dieter; Nargang, Frank E.; Neupert, Walter; Nussberger, Stephan

    1999-01-01

    Translocation of nuclear-encoded preproteins across the outer membrane of mitochondria is mediated by the multicomponent transmembrane TOM complex. We have isolated the TOM core complex of Neurospora crassa by removing the receptors Tom70 and Tom20 from the isolated TOM holo complex by treatment with the detergent dodecyl maltoside. It consists of Tom40, Tom22, and the small Tom components, Tom6 and Tom7. This core complex was also purified directly from mitochondria after solubilization with dodecyl maltoside. The TOM core complex has the characteristics of the general insertion pore; it contains high-conductance channels and binds preprotein in a targeting sequence-dependent manner. It forms a double ring structure that, in contrast to the holo complex, lacks the third density seen in the latter particles. Three-dimensional reconstruction by electron tomography exhibits two open pores traversing the complex with a diameter of ∼2.1 nm and a height of ∼7 nm. Tom40 is the key structural element of the TOM core complex. PMID:10579717

  19. Nucleosome Core Particle

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Nucleosome Core Particle grown on STS-81. The fundamental structural unit of chromatin and is the basis for organization within the genome by compaction of DNA within the nucleus of the cell and by making selected regions of chromosomes available for transcription and replication. Principal Investigator's are Dr. Dan Carter and Dr. Gerard Bunick of New Century Pharmaceuticals.

  20. From Context to Core

    ERIC Educational Resources Information Center

    Campus Technology, 2008

    2008-01-01

    At Campus Technology 2008, Arizona State University Technology Officer Adrian Sannier mesmerized audiences with his mandate to become more efficient by doing only the "core" tech stuff--and getting someone else to slog through the context. This article presents an excerpt from Sannier's hour-long keynote address at Campus Technology '08. Sannier…

  1. XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans

    PubMed Central

    Dewal, Mahender B.; DiChiara, Andrew S.; Antonopoulos, Aristotelis; Taylor, Rebecca J.; Harmon, Chyleigh J.; Haslam, Stuart M.; Dell, Anne; Shoulders, Matthew D.

    2015-01-01

    SUMMARY The molecular architecture of the mature N-glycome is dynamic, with consequences for both normal and pathologic processes. Elucidating cellular mechanisms that modulate the N-linked glycome is, therefore, crucial. The unfolded protein response (UPR) is classically responsible for maintaining proteostasis in the secretory pathway by defining levels of chaperones and quality control proteins. Here, we employ chemical biology methods for UPR regulation to show that stress-independent activation of the UPR’s XBP1s transcription factor also induces a panel of N-glycan maturation-related enzymes. The downstream consequence is a distinctive shift towards specific hybrid and complex N-glycans on N-glycoproteins produced from XBP1s-activated cells, which we characterize by mass spectrometry. Pulse-chase studies attribute this shift specifically to altered N-glycan processing, rather than to changes in degradation or secretion rates. Our findings implicate XBP1s in a new role for N-glycoprotein biosynthesis, unveiling an important link between intracellular stress responses and the molecular architecture of extracellular N-glycoproteins. PMID:26496683

  2. Downregulation of FOXP1 Inhibits Cell Proliferation in Hepatocellular Carcinoma by Inducing G1/S Phase Cell Cycle Arrest

    PubMed Central

    Wang, Xin; Sun, Ji; Cui, Meiling; Zhao, Fangyu; Ge, Chao; Chen, Taoyang; Yao, Ming; Li, Jinjun

    2016-01-01

    Forkhead box P1 (FOXP1) belongs to a family of winged-helix transcription factors that are involved in the processes of cellular proliferation, differentiation, metabolism, and longevity. FOXP1 can affect cell proliferation and migratory ability in hepatocellular carcinoma (HCC) in vitro. However, little is known about the mechanism of FOXP1 in the proliferation of HCC cells. This study aimed to further explore the function of FOXP1 on the proliferation of HCC cells as well as the relevant mechanism involved. Western blot analysis, tumor xenograft models, and flow cytometry analysis were performed to elucidate the function of FOXP1 in the regulation of cell proliferation in human HCC. We observed that silencing FOXP1 significantly suppressed the growth ability of HCC cells both in vitro and in vivo. In addition, knockdown of FOXP1 induced G1/S phase arrest, and the expression of total and phosphorylated Rb (active type) as well as the levels of E2F1 were markedly decreased at 24 h; however, other proteins, including cyclin-dependent kinase (CDK) 4 and 6 and cyclin D1 did not show noticeable changes. In conclusion, downregulation of FOXP1 inhibits cell proliferation in hepatocellular carcinoma by inducing G1/S phase cell cycle arrest, and the decrease in phosphorylated Rb is the main contributor to this G1/S phase arrest. PMID:27618020

  3. Lunar Polar Coring Lander

    NASA Technical Reports Server (NTRS)

    Angell, David; Bealmear, David; Benarroche, Patrice; Henry, Alan; Hudson, Raymond; Rivellini, Tommaso; Tolmachoff, Alex

    1990-01-01

    Plans to build a lunar base are presently being studied with a number of considerations. One of the most important considerations is qualifying the presence of water on the Moon. The existence of water on the Moon implies that future lunar settlements may be able to use this resource to produce things such as drinking water and rocket fuel. Due to the very high cost of transporting these materials to the Moon, in situ production could save billions of dollars in operating costs of the lunar base. Scientists have suggested that the polar regions of the Moon may contain some amounts of water ice in the regolith. Six possible mission scenarios are suggested which would allow lunar polar soil samples to be collected for analysis. The options presented are: remote sensing satellite, two unmanned robotic lunar coring missions (one is a sample return and one is a data return only), two combined manned and robotic polar coring missions, and one fully manned core retrieval mission. One of the combined manned and robotic missions has been singled out for detailed analysis. This mission proposes sending at least three unmanned robotic landers to the lunar pole to take core samples as deep as 15 meters. Upon successful completion of the coring operations, a manned mission would be sent to retrieve the samples and perform extensive experiments of the polar region. Man's first step in returning to the Moon is recommended to investigate the issue of lunar polar water. The potential benefits of lunar water more than warrant sending either astronauts, robots or both to the Moon before any permanent facility is constructed.

  4. Ionic bonding of lanthanides, as influenced by d- and f-atomic orbitals, by core-shells and by relativity.

    PubMed

    Ji, Wen-Xin; Xu, Wei; Schwarz, W H Eugen; Wang, Shu-Guang

    2015-03-15

    Lanthanide trihalide molecules LnX3 (X = F, Cl, Br, I) were quantum chemically investigated, in particular detail for Ln = Lu (lutetium). We applied density functional theory (DFT) at the nonrelativistic and scalar and SO-coupled relativistic levels, and also the ab initio coupled cluster approach. The chemically active electron shells of the lanthanide atoms comprise the 5d and 6s (and 6p) valence atomic orbitals (AO) and also the filled inner 4f semivalence and outer 5p semicore shells. Four different frozen-core approximations for Lu were compared: the (1s(2) -4d(10) ) [Pd] medium core, the [Pd+5s(2) 5p(6) = Xe] and [Pd+4f(14) ] large cores, and the [Pd+4f(14) +5s(2) 5p(6) ] very large core. The errors of LuX bonding are more serious on freezing the 5p(6) shell than the 4f(14) shell, more serious upon core-freezing than on the effective-core-potential approximation. The LnX distances correlate linearly with the AO radii of the ionic outer shells, Ln(3+) -5p(6) and X(-) -np(6) , characteristic for dominantly ionic Ln(3+) -X(-) binding. The heavier halogen atoms also bind covalently with the Ln-5d shell. Scalar relativistic effects contract and destabilize the LuX bonds, spin orbit coupling hardly affects the geometries but the bond energies, owing to SO effects in the free atoms. The relativistic changes of bond energy BE, bond length Re , bond force k, and bond stretching frequency vs do not follow the simple rules of Badger and Gordy (Re ∼BE∼k∼vs ). The so-called degeneracy-driven covalence, meaning strong mixing of accidentally near-degenerate, nearly nonoverlapping AOs without BE contribution is critically discussed.

  5. Search for Di-Muon Decays of a Light Scalar Higgs Boson in Radiative Upsilon(1S) Decays

    SciTech Connect

    Prasad, Vindhyawasini

    2013-08-01

    We search for di-muon decays of a low-mass Higgs boson (A0) in the fully reconstructed decay chain of Υ(2S, 3S ) → π+π-Υ(1S ), Υ(1S ) → γA0, A0 → μ+μ+. The A0 is predicted by several extensions of the Standard Model (SM), including the Next-to-Minimal Supersymmetric Standard Model (NMSSM). NMSSM introduces a CP-odd light Higgs boson whose mass could be less than 10 GeV/c2. The data samples used in this analysis contain 92.8 × 106 Υ(2S ) and 116.8 × 106 Υ(3S ) events collected by the BABAR detector. The Υ(1S ) sample is selected by tagging the pion pair in the Υ(2S, 3S ) → π+π-Υ(1S ) transitions. We find no evidence for A0 production and set 90% confidence level (C.L.) upper limits on the product branching fraction B(Υ(1S ) → γA0) × B(A0 → μ+μ-) in the range of (0.28 - 9.7) × 10-6 for 0.212 ≤ mA0 ≤ 9.20 GeV/c2. We also combine our results with previous BABAR results of Υ(2S, 3S ) → γA0, A0 → μ+μ- to set limits on the effective coupling ( fΥ) of the b-quark to the A0, f 2 Υ × B(A0 → μ+μ-), at the level of (0.29- 40) × 10-6 for 0.212 ≤ mA0 ≤ 9.2 GeV/c2.

  6. Off-resonance photoemission dynamics studied by recoil frame F1s and C1s photoelectron angular distributions of CH{sub 3}F

    SciTech Connect

    Stener, M. Decleva, P.; Mizuno, T.; Yagishita, A.; Yoshida, H.

    2014-01-28

    F1s and C1s photoelectron angular distributions are considered for CH{sub 3}F, a molecule which does not support any shape resonance. In spite of the absence of features in the photoionization cross section profile, the recoil frame photoelectron angular distributions (RFPADs) exhibits dramatic changes depending on both the photoelectron energy and polarization geometry. Time-dependent density functional theory calculations are also given to rationalize the photoionization dynamics. The RFPADs have been compared with the theoretical calculations, in order to assess the accuracy of the theoretical method and rationalize the experimental findings. The effect of finite acceptance angles for both ionic fragments and photoelectrons has been included in the calculations, as well as the effect of rotational averaging around the fragmentation axis. Excellent agreement between theory and experiment is obtained, confirming the good quality of the calculated dynamical quantities (dipole moments and phase shifts)

  7. 7. JOB NO. 1347G, SHEET 1S, 1929, OIL HOUSE; FORD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. JOB NO. 1347-G, SHEET 1S, 1929, OIL HOUSE; FORD MOTOR COMPANY; PLANS, SECTIONS AND DETAILS - Ford Motor Company Long Beach Assembly Plant, Oil House, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

  8. Observation of Upsilon(2S)-->etaUpsilon(1S) and search for related transitions.

    PubMed

    He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Xavier, J V; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Martin, L; Powell, A; Wilkinson, G; Ecklund, K M; Love, W; Savinov, V; Mendez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J

    2008-11-07

    We report the first observation of Upsilon(2S)-->etaUpsilon(1S), with a branching fraction B=(2.1(-0.6)+0.7(stat)+/-0.3(syst)) x 10(-4) and a statistical significance 5.3sigma. Data were acquired with the CLEO III detector at the CESR e+e(-) symmetric collider. This is the first process observed involving a b-quark spin flip. For related transitions, 90% confidence limits in units of 10(-4) are B(Upsilon(2S)-->pi0Upsilon(1S)) < 1.8, B(Upsilon(3S)-->etaUpsilon(1S)) < 1.8, B(Upsilon(3S)-->pi0Upsilon(1S)) < 0.7, and B(Upsilon(3S)-->pi0Upsilon(2S)) < 5.1.

  9. Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

    PubMed

    Vachal, Petr; Toth, Leslie M; Hale, Jeffrey J; Yan, Lin; Mills, Sander G; Chrebet, Gary L; Koehane, Carol A; Hajdu, Richard; Milligan, James A; Rosenbach, Mark J; Mandala, Suzanne

    2006-07-15

    Novel series of sphingosine-1-phosphate (S1P) receptor agonists were developed through a systematic SAR aimed to achieve high selectivity for a single member of the S1P family of receptors, S1P1. The optimized structure represents a highly S1P1-selective and efficacious agonist: S1P1/S1P2, S1P1/S1P3, S1P1/S1P4>10,000-fold, S1P1/S1P5>600-fold, while EC50 (S1P1) <0.2 nM. In vivo experiments are consistent with S1P1 receptor agonism alone being sufficient for achieving desired lymphocyte-lowering effect.

  10. 5. SWITCH TOWER AND JUNCTION OF S.A.R. #1 & S.A.R. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. SWITCH TOWER AND JUNCTION OF S.A.R. #1 & S.A.R. #2 TRANSMISSION LINES, MARCH 7, 1916. SCE drawing no. 4932. - Santa Ana River Hydroelectric System, Transmission Lines, Redlands, San Bernardino County, CA

  11. Lepton Universality Test in Upsilon(1S) Decays at BaBar

    SciTech Connect

    Guido, Elisa; /Genoa U. /INFN, Genoa

    2012-04-10

    Using a sample of 122 million {Upsilon}(3S) decays collected with the BABAR detector at the PEP-II asymmetric energy collider at the SLAC National Accelerator Laboratory, we measure the ratio R{sub {tau}{mu}} = BR({Upsilon}(1S) {yields} {tau}{sup +}{tau}{sup -})/BR({Upsilon}(1S) {yields} {mu}{sup +}{mu}{sup -}); the measurement is intended as a test of lepton universality and as a possible search for a light pseudoscalar Higgs boson in Next to Minimal Supersymmetric Standard Model (NMSSM) scenarios. Such a boson could appear in a deviation of the ratio R{sub {tau}{mu}} from the Standard Model expectation, that is 1, except for small lepton mass corrections. The analysis exploits the decays {Upsilon}(3S) {yields} {Upsilon}(1S){pi}{sup +}{pi}{sup -}, {Upsilon}(1S) {yields} l{sup +}l{sup -}, where l = {mu},{tau}.

  12. Application of Core Dynamics Modeling to Core-Mantle Interactions

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia

    2003-01-01

    Observations have demonstrated that length of day (LOD) variation on decadal time scales results from exchange of axial angular momentum between the solid mantle and the core. There are in general four core-mantle interaction mechanisms that couple the core and the mantle. Of which, three have been suggested likely the dominant coupling mechanism for the decadal core-mantle angular momentum exchange, namely, gravitational core-mantle coupling arising from density anomalies in the mantle and in the core (including the inner core), the electromagnetic coupling arising from Lorentz force in the electrically conducting lower mantle (e.g. D-layer), and the topographic coupling arising from non-hydrostatic pressure acting on the core-mantle boundary (CMB) topography. In the past decades, most effort has been on estimating the coupling torques from surface geomagnetic observations (kinematic approach), which has provided insights on the core dynamical processes. In the meantime, it also creates questions and concerns on approximations in the studies that may invalidate the corresponding conclusions. The most serious problem is perhaps the approximations that are inconsistent with dynamical processes in the core, such as inconsistencies between the core surface flow beneath the CMB and the CMB topography, and that between the D-layer electric conductivity and the approximations on toroidal field at the CMB. These inconsistencies can only be addressed with numerical core dynamics modeling. In the past few years, we applied our MoSST (Modular, Scalable, Self-consistent and Three-dimensional) core dynamics model to study core-mantle interactions together with geodynamo simulation, aiming at assessing the effect of the dynamical inconsistencies in the kinematic studies on core-mantle coupling torques. We focus on topographic and electromagnetic core-mantle couplings and find that, for the topographic coupling, the consistency between the core flow and the CMB topography is

  13. Sampling and Analysis Plan for Old Solvent Tanks S1-S22 to Address Waste Acceptance Criteria

    SciTech Connect

    Filpus-Luyckx, P.E.

    1997-10-02

    The Environmental Restoration Department (ERD) assumed custody of the Old Solvent Tanks (Tanks S1-S22) in the Old Radioactive Waste Burial Ground (ORWBG, 643-E) from Waste Management in January 1991. The purpose of this Sampling and Analysis Plan (SAP) is to collect and analyze samples of the sludge solids, organic and aqueous phases to determine the level of radioactivity, the isotopic constituents, the specific gravity, and other physical parameters. These data must be obtained to evaluate the process safety of remediating the tanks, to determine the disposal path for the material in the tanks, and to determine the most viable closure technology for the tanks.

  14. Leptonic decay of the ϒ(1S) meson at third order in QCD.

    PubMed

    Beneke, Martin; Kiyo, Yuichiro; Marquard, Peter; Penin, Alexander; Piclum, Jan; Seidel, Dirk; Steinhauser, Matthias

    2014-04-18

    We present the complete next-to-next-to-next-to-leading order short-distance and bound-state QCD correction to the leptonic decay rate Γ(ϒ(1S)→ℓ+ℓ-) of the lowest-lying spin-1 bottomonium state. The perturbative QCD prediction is compared to the measurement Γ(ϒ(1S)→e+e-)=1.340(18)  keV.

  15. Isotope shifts of the three lowest 1S states of the B+ ion calculated with a finite-nuclear-mass approach and with relativistic and quantum electrodynamics corrections.

    PubMed

    Bubin, Sergiy; Komasa, Jacek; Stanke, Monika; Adamowicz, Ludwik

    2010-03-21

    We present very accurate quantum mechanical calculations of the three lowest S-states [1s(2)2s(2)((1)S(0)), 1s(2)2p(2)((1)S(0)), and 1s(2)2s3s((1)S(0))] of the two stable isotopes of the boron ion, (10)B(+) and (11)B(+). At the nonrelativistic level the calculations have been performed with the Hamiltonian that explicitly includes the finite mass of the nucleus as it was obtained by a rigorous separation of the center-of-mass motion from the laboratory frame Hamiltonian. The spatial part of the nonrelativistic wave function for each state was expanded in terms of 10,000 all-electron explicitly correlated Gaussian functions. The nonlinear parameters of the Gaussians were variationally optimized using a procedure involving the analytical energy gradient determined with respect to the nonlinear parameters. The nonrelativistic wave functions of the three states were subsequently used to calculate the leading alpha(2) relativistic corrections (alpha is the fine structure constant; alpha=1/c, where c is the speed of light) and the alpha(3) quantum electrodynamics (QED) correction. We also estimated the alpha(4) QED correction by calculating its dominant component. A comparison of the experimental transition frequencies with the frequencies obtained based on the energies calculated in this work shows an excellent agreement. The discrepancy is smaller than 0.4 cm(-1).

  16. Nrdp1S, short variant of Nrdp1, inhibits human glioma progression by increasing Nrdp1-mediated ErbB3 ubiquitination and degradation.

    PubMed

    Wu, Yuxuan; Wang, Lei; Bao, Hanmo; Zou, Shenshan; Fu, Chunling; Gong, Hui; Gao, Yong; Tang, Yuan; Yu, Rutong; Shi, Hengliang

    2016-03-01

    The ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) is involved in the induction of apoptosis and suppression of tumour formation. We previously showed that it was expressed at lower levels in human glioma tissues compared with normal brain tissues. However, the mechanism underlying this is unclear. Here, we reported that a novel short variant (Nrdp1S), lacking 71 amino acids at the N-terminal, was expressed in normal human brain tissue, but absent from glioma tissues. Similar to Nrdp1, Nrdp1S could be degraded by the proteasomal pathway, but exhibited an even longer half-life than Nrdp1. Nrdp1S was also shown to form a heterodimer with Nrdp1, which increased its stability, thereby augmenting the Nrdp1-mediated ubiquitination and degradation of ErbB3. EdU incorporation, MTT assay and in vitro colony formation demonstrated that Nrdp1S significantly inhibited the cell tumourigenicity. These results together suggest that Nrdp1S is a tumour suppressor that which potentiates the Nrdp1-mediated ubiquitination and degradation of ErbB3. An Nrdp1S deficiency may also be an important factor in the loss of Nrdp1.

  17. Test of Lepton Universality in Upsilon(1S) Decays at BaBar

    SciTech Connect

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Battaglia, M.; Brown, David Nathan; Hooberman, B.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; Tanabe, T.; /more authors..

    2010-06-07

    The ratio R{sub {tau}{mu}}({Upsilon}(1S))={Lambda}{sub {Upsilon}(1S){yields}{tau}{sup +}{tau}{sup -}}/{Lambda}{sub {Upsilon}(1S){yields}{mu}{sup +}{mu}{sup -}} is measured using a sample of (121.8 {+-} 1.2) x 10{sup 6}{Upsilon}(3S) events recorded by the BABAR detector. This measurement is intended as a test of lepton universality and as a search for a possible light pseudoscalar Higgs boson. In the standard model (SM) this ratio is expected to be close to 1. Any significant deviations would violate lepton universality and could be introduced by the coupling to a light pseudoscalar Higgs boson. The analysis studies the decays {Upsilon}(3S) {yields} {Upsilon}(1S){sub {pi}{sup +}{pi}{sup -}}, {Upsilon}(1S) {yields} {ell}{sup +}{ell}{sup -}, where l = {mu}, {tau}. The result, R{sub {tau}{mu}}({Upsilon}(1S))=1.005 {+-} 0.013(stat) {+-} 0.022(syst), shows no deviation from the expected SM value, while improving the precision with respect to previous measurements.

  18. Radiative decays of the {upsilon}(1S) to a pair of charged hadrons

    SciTech Connect

    Athar, S.B.; Avery, P.; Breva-Newell, L.; Patel, R.; Potlia, V.; Stoeck, H.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B.I.; Gollin, G.D.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E.J.; Williams, J.; Wiss, J.

    2006-02-01

    Using data obtained with the CLEO III detector, running at the Cornell Electron Storage Ring (CESR), we report on a new study of exclusive radiative {upsilon}(1S) decays into the final states {gamma}{pi}{sup +}{pi}{sup -}, {gamma}K{sup +}K{sup -}, and {gamma}pp. We present branching ratio measurements for the decay modes {upsilon}(1S){yields}{gamma}f{sub 2}(1270), {upsilon}(1S){yields}{gamma}f{sub 2}{sup '}(1525), and {upsilon}(1S){yields}{gamma}K{sup +}K{sup -}; helicity production ratios for f{sub 2}(1270) and f{sub 2}{sup '}(1525); upper limits for the decay {upsilon}(1S){yields}{gamma}f{sub J}(2200), with f{sub J}(2220){yields}{pi}{sup +}{pi}{sup -}, K{sup +}K{sup -}, pp; and an upper limit for the decay {upsilon}(1S){yields}{gamma}X(1860), with X(1860){yields}{gamma}pp.

  19. Simulation of XPS C1s spectra of organic monolayers by quantum chemical methods.

    PubMed

    Giesbers, Marcel; Marcelis, Antonius T M; Zuilhof, Han

    2013-04-16

    Several simple methods are presented and evaluated to simulate the X-ray photoelectron spectra (XPS) of organic monolayers and polymeric layers by density functional theory (DFT) and second-order Møller-Plesset theory (MP2) in combination with a series of basis sets. The simulated carbon (C1s) XPS spectra as obtained via B3LYP/6-311G(d,p) or M11/6-311G(d,p) calculations are in good agreement (average mean error <0.3 eV) with the experimental spectra, and good estimates of C1s spectra can be obtained via E(C1s)(exp) = 0.9698EC1s(theory) + 20.34 (in eV) (B3LYP/6-311G(d,p)). As a result, the simulated C1s XPS spectra can elucidate the binding energies of the different carbon species within an organic layer and, in this way, greatly aid the assignment of complicated C1s XPS spectra. The paper gives a wide range of examples, including haloalkanes, esters, (thio-)ethers, leaving groups, clickable functionalities, and bioactive moieties.

  20. Test of lepton universality in Υ(1S) decays at BABAR.

    PubMed

    del Amo Sanchez, P; Lees, J P; Poireau, V; Prencipe, E; Tisserand, V; Garra Tico, J; Grauges, E; Martinelli, M; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Battaglia, M; Brown, D N; Hooberman, B; Kerth, L T; Kolomensky, Yu G; Lynch, G; Osipenkov, I L; Tanabe, T; Hawkes, C M; Soni, N; Watson, A T; Koch, H; Schroeder, T; Asgeirsson, D J; Hearty, C; Mattison, T S; McKenna, J A; Khan, A; Randle-Conde, A; Blinov, V E; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Yushkov, A N; Bondioli, M; Curry, S; Kirkby, D; Lankford, A J; Mandelkern, M; Martin, E C; Stoker, D P; Atmacan, H; Gary, J W; Liu, F; Long, O; Vitug, G M; Yasin, Z; Sharma, V; Campagnari, C; Hong, T M; Kovalskyi, D; Richman, J D; Eisner, A M; Heusch, C A; Kroseberg, J; Lockman, W S; Martinez, A J; Schalk, T; Schumm, B A; Seiden, A; Winstrom, L O; Cheng, C H; Doll, D A; Echenard, B; Hitlin, D G; Ongmongkolkul, P; Porter, F C; Rakitin, A Y; Andreassen, R; Dubrovin, M S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Bloom, P C; Ford, W T; Gaz, A; Hirschauer, J F; Nagel, M; Nauenberg, U; Smith, J G; Wagner, S R; Ayad, R; Toki, W H; Hauke, A; Jasper, H; Karbach, T M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Kobel, M J; Schubert, K R; Schwierz, R; Bernard, D; Verderi, M; Clark, P J; Playfer, S; Watson, J E; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Fioravanti, E; Franchini, P; Luppi, E; Munerato, M; Negrini, M; Petrella, A; Piemontese, L; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Nicolaci, M; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Contri, R; Guido, E; Lo Vetere, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Tosi, S; Bhuyan, B; Morii, M; Adametz, A; Marks, J; Schenk, S; Uwer, U; Bernlochner, F U; Lacker, H M; Lueck, T; Volk, A; Dauncey, P D; Tibbetts, M; Behera, P K; Mallik, U; Chen, C; Cochran, J; Crawley, H B; Dong, L; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Arnaud, N; Davier, M; Derkach, D; Firmino da Costa, J; Grosdidier, G; Le Diberder, F; Lutz, A M; Malaescu, B; Perez, A; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, L; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Paramesvaran, S; Wren, A C; Brown, D N; Davis, C L; Denig, A G; Fritsch, M; Gradl, W; Hafner, A; Alwyn, K E; Bailey, D; Barlow, R J; Jackson, G; Lafferty, G D; West, T J; Anderson, J; Cenci, R; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Salvati, E; Cowan, R; Dujmic, D; Fisher, P H; Sciolla, G; Yamamoto, R K; Zhao, M; Patel, P M; Robertson, S H; Schram, M; Biassoni, P; Lazzaro, A; Lombardo, V; Palombo, F; Stracka, S; Cremaldi, L; Godang, R; Kroeger, R; Sonnek, P; Summers, D J; Zhao, H W; Nguyen, X; Simard, M; Taras, P; De Nardo, G; Monorchio, D; Onorato, G; Sciacca, C; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Wang, W F; Corwin, L A; Honscheid, K; Kass, R; Morris, J P; Rahimi, A M; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Castelli, G; Feltresi, E; Gagliardi, N; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Ben-Haim, E; Bonneaud, G R; Briand, H; Chauveau, J; Hamon, O; Leruste, Ph; Marchiori, G; Ocariz, J; Prendki, J; Sitt, S; Biasini, M; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Calderini, G; Carpinelli, M; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Lopes Pegna, D; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Anulli, F; Baracchini, E; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Piredda, G; Renga, F; Ebert, M; Hartmann, T; Leddig, T; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Hamel de Monchenault, G; Vasseur, G; Yèche, Ch; Zito, M; Allen, M T; Aston, D; Bard, D J; Bartoldus, R; Benitez, J F; Cartaro, C; Convery, M R; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Franco Sevilla, M; Fulsom, B G; Gabareen, A M; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Muller, D R; Neal, H; Nelson, S; O'Grady, C P; Ofte, I; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Santoro, V; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; West, C A; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Young, C C; Ziegler, V; Chen, X R; Park, W; Purohit, M V; White, R M; Wilson, J R; Sekula, S J; Bellis, M; Burchat, P R; Edwards, A J; Miyashita, T S; Ahmed, S; Alam, M S; Ernst, J A; Pan, B; Saeed, M A; Zain, S B; Guttman, N; Soffer, A; Lund, P; Spanier, S M; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Wray, B C; Izen, J M; Lou, X C; Bianchi, F; Gamba, D; Pelliccioni, M; Bomben, M; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Choi, H H F; Hamano, K; King, G J; Kowalewski, R; Lewczuk, M J; Nugent, I M; Roney, J M; Sobie, R J; Gershon, T J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Puccio, E M T; Band, H R; Chen, X; Dasu, S; Flood, K T; Pan, Y; Pierini, M; Prepost, R; Vuosalo, C O; Wu, S L

    2010-05-14

    The ratio R(τμ)(Υ(1S))=Γ(Υ(1S)→τ+ τ-)/Γ(Υ(1S)→μ+ μ-) is measured using a sample of (121.8±1.2)×10(6)Υ(3S) events recorded by the BABAR detector. This measurement is intended as a test of lepton universality and as a search for a possible light pseudoscalar Higgs boson. In the standard model (SM) this ratio is expected to be close to 1. Any significant deviations would violate lepton universality and could be introduced by the coupling to a light pseudoscalar Higgs boson. The analysis studies the decays Υ(3S)→Υ(1S)π+ π-, Υ(1S)→l+ l-, where l=μ, τ. The result, R(τμ)(Υ(1S))=1.005±0.013(stat)±0.022(syst), shows no deviation from the expected SM value, while improving the precision with respect to previous measurements.

  1. MAP1S Protein Regulates the Phagocytosis of Bacteria and Toll-like Receptor (TLR) Signaling.

    PubMed

    Shi, Ming; Zhang, Yifan; Liu, Leyuan; Zhang, Tingting; Han, Fang; Cleveland, Joseph; Wang, Fen; McKeehan, Wallace L; Li, Yu; Zhang, Dekai

    2016-01-15

    Phagocytosis is a critical cellular process for innate immune defense against microbial infection. The regulation of phagocytosis process is complex and has not been well defined. An intracellular molecule might regulate cell surface-initiated phagocytosis, but the underlying molecular mechanism is poorly understood (1). In this study, we found that microtubule-associated protein 1S (MAP1S), a protein identified recently that is involved in autophagy (2), is expressed primarily in macrophages. MAP1S-deficient macrophages are impaired in the phagocytosis of bacteria. Furthermore, we demonstrate that MAP1S interacts directly with MyD88, a key adaptor of Toll-like receptors (TLRs), upon TLR activation and affects the TLR signaling pathway. Intriguingly, we also observe that, upon TLR activation, MyD88 participates in autophagy processing in a MAP1S-dependent manner by co-localizing with MAP1 light chain 3 (MAP1-LC3 or LC3). Therefore, we reveal that an intracellular autophagy-related molecule of MAP1S controls bacterial phagocytosis through TLR signaling.

  2. Core Skills Assessment to Improve Mathematical Competency

    ERIC Educational Resources Information Center

    Carr, Michael; Bowe, Brian; Ní Fhloinn, Eabhnat

    2013-01-01

    Many engineering undergraduates begin third-level education with significant deficiencies in their core mathematical skills. Every year, in the Dublin Institute of Technology, a diagnostic test is given to incoming first-year students, consistently revealing problems in basic mathematics. It is difficult to motivate students to address these…

  3. Health Care Assistant Core. Instructor Manual.

    ERIC Educational Resources Information Center

    Feilner, Veronica; Robling, Jeannine

    This document contains the core curriculum for a basic high school course for health care assistants. It is designed as a 1-semester course of study, after which students can take a course in an emphasis area, such as veterinary, nursing, pharmacology, or physical therapy, in which they learn skills for specific entry-level jobs. The curriculum…

  4. Core Outlet Temperature Study

    SciTech Connect

    Moisseytsev, A.; Hoffman, E.; Majumdar, S.

    2008-07-28

    It is a known fact that the power conversion plant efficiency increases with elevation of the heat addition temperature. The higher efficiency means better utilization of the available resources such that higher output in terms of electricity production can be achieved for the same size and power of the reactor core or, alternatively, a lower power core could be used to produce the same electrical output. Since any nuclear power plant, such as the Advanced Burner Reactor, is ultimately built to produce electricity, a higher electrical output is always desirable. However, the benefits of the higher efficiency and electricity production usually come at a price. Both the benefits and the disadvantages of higher reactor outlet temperatures are analyzed in this work.

  5. Dynamics of core accretion

    DOE PAGES

    Nelson, Andrew F.; Ruffert, Maximilian

    2012-12-21

    In this paper, we perform three-dimensional hydrodynamic simulations of gas flowing around a planetary core of mass Mpl = 10M⊕ embedded in a near Keplerian background flow, using a modified shearing box approximation. We assume an ideal gas behaviour following an equation of state with a fixed ratio of the specific heats, γ = 1.42, consistent with the conditions of a moderate-temperature background disc with solar composition. No radiative heating or cooling is included in the models. We employ a nested grid hydrodynamic code implementing the ‘Piecewise Parabolic Method’ with as many as six fixed nested grids, providing spatial resolutionmore » on the finest grid comparable to the present-day diameters of Neptune and Uranus. We find that a strongly dynamically active flow develops such that no static envelope can form. The activity is not sensitive to plausible variations in the rotation curve of the underlying disc. It is sensitive to the thermodynamic treatment of the gas, as modelled by prescribed equations of state (either ‘locally isothermal’ or ‘locally isentropic’) and the temperature of the background disc material. The activity is also sensitive to the shape and depth of the core's gravitational potential, through its mass and gravitational softening coefficient. Each of these factors influences the magnitude and character of hydrodynamic feedback of the small-scale flow on the background, and we conclude that accurate modelling of such feedback is critical to a complete understanding of the core accretion process. The varying flow pattern gives rise to large, irregular eruptions of matter from the region around the core which return matter to the background flow: mass in the envelope at one time may not be found in the envelope at any later time. No net mass accretion into the envelope is observed over the course of the simulation and none is expected, due to our neglect of cooling. Except in cases of very rapid cooling however, as

  6. Dynamics of core accretion

    SciTech Connect

    Nelson, Andrew F.; Ruffert, Maximilian

    2012-12-21

    In this paper, we perform three-dimensional hydrodynamic simulations of gas flowing around a planetary core of mass Mpl = 10M embedded in a near Keplerian background flow, using a modified shearing box approximation. We assume an ideal gas behaviour following an equation of state with a fixed ratio of the specific heats, γ = 1.42, consistent with the conditions of a moderate-temperature background disc with solar composition. No radiative heating or cooling is included in the models. We employ a nested grid hydrodynamic code implementing the ‘Piecewise Parabolic Method’ with as many as six fixed nested grids, providing spatial resolution on the finest grid comparable to the present-day diameters of Neptune and Uranus. We find that a strongly dynamically active flow develops such that no static envelope can form. The activity is not sensitive to plausible variations in the rotation curve of the underlying disc. It is sensitive to the thermodynamic treatment of the gas, as modelled by prescribed equations of state (either ‘locally isothermal’ or ‘locally isentropic’) and the temperature of the background disc material. The activity is also sensitive to the shape and depth of the core's gravitational potential, through its mass and gravitational softening coefficient. Each of these factors influences the magnitude and character of hydrodynamic feedback of the small-scale flow on the background, and we conclude that accurate modelling of such feedback is critical to a complete understanding of the core accretion process. The varying flow pattern gives rise to large, irregular eruptions of matter from the region around the core which return matter to the background flow: mass in the envelope at one time may not be found in the envelope at any later time. No net mass accretion into the envelope is observed over the course of the simulation and none is expected, due to our neglect of cooling. Except in cases of very rapid cooling

  7. Long Valley Coring Project

    USGS Publications Warehouse

    Sass, John; Finger, John; McConnel, Vicki

    1998-01-01

    In December 1997, the California Energy Commission (CEC) agreed to provide funding for Phase III continued drilling of the Long Valley Exploratory Well (LVEW) near Mammoth Lakes, CA, from its present depth. The CEC contribution of $1 million completes a funding package of $2 million from a variety of sources, which will allow the well to be cored continuously to a depth of between 11,500 and 12,500 feet. The core recovered from Phase III will be crucial to understanding the origin and history of the hydrothermal systems responsible for the filling of fractures in the basement rock. The borehole may penetrate the metamorphic roof of the large magmatic complex that has fed the volcanism responsible for the caldera and subsequent activity.

  8. Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

    PubMed

    Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

    2016-12-21

    Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation.

  9. Banded electromagnetic stator core

    DOEpatents

    Fanning, Alan W.; Gonzales, Aaron A.; Patel, Mahadeo R.; Olich, Eugene E.

    1996-01-01

    A stator core for an electromagnetic pump includes a plurality of circumferentially adjoining groups of flat laminations disposed about a common centerline axis and collectively defining a central bore and a discontinuous outer perimeter, with adjacent groups diverging radially outwardly to form V-shaped gaps. An annular band surrounds the groups and is predeterminedly tensioned to clamp together the laminations, and has a predetermined flexibility in a radial direction to form substantially straight bridge sections between the adjacent groups.

  10. Banded electromagnetic stator core

    DOEpatents

    Fanning, A.W.; Gonzales, A.A.; Patel, M.R.; Olich, E.E.

    1994-04-05

    A stator core for an electromagnetic pump includes a plurality of circumferentially adjoining groups of flat laminations disposed about a common centerline axis and collectively defining a central bore and a discontinuous outer perimeter, with adjacent groups diverging radially outwardly to form V-shaped gaps. An annular band surrounds the groups and is predeterminedly tensioned to clamp together the laminations, and has a predetermined flexibility in a radial direction to form substantially straight bridge sections between the adjacent groups. 5 figures.

  11. Banded electromagnetic stator core

    DOEpatents

    Fanning, Alan W.; Gonzales, Aaron A.; Patel, Mahadeo R.; Olich, Eugene E.

    1994-01-01

    A stator core for an electromagnetic pump includes a plurality of circumferentially adjoining groups of flat laminations disposed about a common centerline axis and collectively defining a central bore and a discontinuous outer perimeter, with adjacent groups diverging radially outwardly to form V-shaped gaps. An annular band surrounds the groups and is predeterminedly tensioned to clamp together the laminations, and has a predetermined flexibility in a radial direction to form substantially straight bridge sections between the adjacent groups.

  12. Banded electromagnetic stator core

    DOEpatents

    Fanning, A.W.; Gonzales, A.A.; Patel, M.R.; Olich, E.E.

    1996-06-11

    A stator core for an electromagnetic pump includes a plurality of circumferentially adjoining groups of flat laminations disposed about a common centerline axis and collectively defining a central bore and a discontinuous outer perimeter, with adjacent groups diverging radially outwardly to form V-shaped gaps. An annular band surrounds the groups and is predeterminedly tensioned to clamp together the laminations, and has a predetermined flexibility in a radial direction to form substantially straight bridge sections between the adjacent groups. 5 figs.

  13. Toroidal core winder

    DOEpatents

    Potthoff, Clifford M.

    1978-01-01

    The disclosure is directed to an apparatus for placing wire windings on a toroidal body, such as a transformer core, having an orifice in its center. The apparatus comprises a wire storage spool, a wire loop holding continuous belt maintained in a C-shaped loop by a belt supporting structure and provision for turning the belt to place and tighten loops of wire on a toroidal body, which is disposed within the gap of the C-shaped belt loop.

  14. Electromagnetic pump stator core

    DOEpatents

    Fanning, A.W.; Olich, E.E.; Dahl, L.R.

    1995-01-17

    A stator core for supporting an electrical coil includes a plurality of groups of circumferentially abutting flat laminations which collectively form a bore and perimeter. A plurality of wedges are interposed between the groups, with each wedge having an inner edge and a thicker outer edge. The wedge outer edges abut adjacent ones of the groups to provide a continuous path around the perimeter. 21 figures.

  15. Fissioning Plasma Core Reactor

    NASA Technical Reports Server (NTRS)

    Albright, Dennis; Butler, Carey; West, Nicole; Cole, John W. (Technical Monitor)

    2002-01-01

    Institute for Scientific Research, Inc. (ISR) research program consist of: 1.Study core physics by adapting existing codes: MCNP4C - Monte Carlo code; COMBINE/VENTURE - diffusion theory; SCALE4 - Monte Carlo, with many utility codes. 2. Determine feasibility and study major design parameters: fuel selection, temperature and reflector sizing. 3. Study reactor kinetics: develop QCALC1 to model point kinetics; study dynamic behavior of the power release.

  16. Variable depth core sampler

    DOEpatents

    Bourgeois, Peter M.; Reger, Robert J.

    1996-01-01

    A variable depth core sampler apparatus comprising a first circular hole saw member, having longitudinal sections that collapses to form a point and capture a sample, and a second circular hole saw member residing inside said first hole saw member to support the longitudinal sections of said first hole saw member and prevent them from collapsing to form a point. The second hole saw member may be raised and lowered inside said first hole saw member.

  17. Some core contested concepts.

    PubMed

    Chomsky, Noam

    2015-02-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and to lead to conclusions about a number of significant issues that differ from some conventional beliefs.

  18. Core-collapse Supernovae

    SciTech Connect

    Hix, William Raphael; Lentz, E. J.; Baird, Mark L; Chertkow, Merek A; Lee, Ching-Tsai; Blondin, J. M.; Bruenn, S. W.; Messer, Bronson; Mezzacappa, Anthony

    2013-01-01

    Marking the inevitable death of a massive star, and the birth of a neutron star or black hole, core-collapse supernovae bring together physics at a wide range in spatial scales, from kilometer-sized hydrodynamic motions (growing to gigameter scale) down to femtometer scale nuclear reactions. Carrying 10$^{51}$ ergs of kinetic energy and a rich-mix of newly synthesized atomic nuclei, core-collapse supernovae are the preeminent foundries of the nuclear species which make up ourselves and our solar system. We will discuss our emerging understanding of the convectively unstable, neutrino-driven explosion mechanism, based on increasingly realistic neutrino-radiation hydrodynamic simulations that include progressively better nuclear and particle physics. Recent multi-dimensional models with spectral neutrino transport from several research groups, which slowly develop successful explosions for a range of progenitors, have motivated changes in our understanding of the neutrino reheating mechanism. In a similar fashion, improvements in nuclear physics, most notably explorations of weak interactions on nuclei and the nuclear equation of state, continue to refine our understanding of how supernovae explode. Recent progress on both the macroscopic and microscopic effects that affect core-collapse supernovae are discussed.

  19. GEOS-CORE

    SciTech Connect

    2014-06-24

    GEOS-CORE is a code that integrates open source Libraries for linear algebra and I/O with two main LLNL-written components: (i) a set of standard finite, discrete, and discontinuous displacement element physics solvers for resolving Darcy fluid flow, explicit mechanics, implicit mechanics, and fluid-mediated fracturing, including resolution of physical behaviors both implicitly and explicitly, and (ii) a MPI-based parallelization implementation for use on generic HPC distributed memory architectures. The resultant code can be used alone for linearly elastic and quasistatic damage problems; problems involving hydraulic fracturing, where the mesh topology is dynamically changed; and general granular materials behavior. The key application domain is for low-rate stimulation and fracture control in subsurface reservoirs (e.g., enhanced geothermal sites and unconventional shale gas stimulation). GEOS-CORE also has interfaces to call external libraries for, e.g., material models and equations fo state; however, LLNL-developed EOS and material models, beyond the aforementioned linear elastic and quasi-static damage models, will not be part of the current release. GEOS-CORE's secondary applications include granular materials behavior under different load paths.

  20. 33. BENCH CORE STATION, GREY IRON FOUNDRY CORE ROOM WHERE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. BENCH CORE STATION, GREY IRON FOUNDRY CORE ROOM WHERE CORE MOLDS WERE HAND FILLED AND OFTEN PNEUMATICALLY COMPRESSED WITH A HAND-HELD RAMMER BEFORE THEY WERE BAKED. - Stockham Pipe & Fittings Company, Grey Iron Foundry, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  1. L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes

    PubMed Central

    Penzkofer, Tobias; Jäger, Marten; Figlerowicz, Marek; Badge, Richard; Mundlos, Stefan; Robinson, Peter N.; Zemojtel, Tomasz

    2017-01-01

    LINE-1 (L1) insertions comprise as much as 17% of the human genome sequence, and similar proportions have been recorded for other mammalian species. Given the established role of L1 retrotransposons in shaping mammalian genomes, it becomes an important task to track and annotate the sources of this activity: full length elements, able to encode the cis and trans acting components of the retrotransposition machinery. The L1Base database (http://l1base.charite.de) contains annotated full-length sequences of LINE-1 transposons including putatively active L1s. For the new version of L1Base, a LINE-1 annotation tool, L1Xplorer, has been used to mine potentially active L1 retrotransposons from the reference genome sequences of 17 mammals. The current release of the human genome, GRCh38, contains 146 putatively active L1 elements or full length intact L1 elements (FLIs). The newest versions of the mouse, GRCm38 and the rat, Rnor_6.0, genomes contain 2811 and 492 FLIs, respectively. Most likely reflecting the current level of completeness of the genome project, the latest reference sequence of the common chimpanzee genome, PT 2.19, only contains 19 FLIs. Of note, the current assemblies of the dog, CF 3.1 and the sheep, OA 3.1, genomes contain 264 and 598 FLIs, respectively. Further developments in the new version of L1Base include an updated website with implementation of modern web server technologies. including a more responsive design for an improved user experience, as well as the addition of data sharing capabilities for L1Xplorer annotation. PMID:27924012

  2. Characterization of N-linked oligosaccharides bearing sialyl lewis x moieties on an alternatively glycosylated form of soluble complement receptor type 1 (sCR1).

    PubMed

    Picard, M D; Pettey, C L; Marsh, H C; Thomas, L J

    2000-02-01

    We sought to produce a complement inhibitory protein possessing oligosaccharides specifically modified to contain the sialyl Lewis x (sLe(x)) moiety. This modified glycoprotein could combine anti-complement activity with the ability to inhibit selectin-mediated interactions and concentrate this activity to sites of activated endothelium where selectins are upregulated. Soluble complement receptor type 1 (sCR1), previously shown to be effective in inhibiting the complement cascade, was produced in a cell line capable of adding fucose to N-linked oligosaccharides in the alpha1-3 linkage, which is necessary for sLe(x) glycosylation. The glycoprotein purified from these cells was designated sCR1sLe(x), and may prove to be more effective than sCR1 in some clinical applications. Detailed analysis and characterization of sCR1sLe(x) was performed to confirm that the N-linked oligosaccharides possessed sLe(x) moieties and also to determine the extent of sLe(x) glycosylation. The glycoproteins were characterized by oligosaccharide profiling, sequencing, linkage analysis and quantified by differential enzymic digestion, using fluorophore-assisted carbohydrate electrophoresis. The major glycans were identified as biantennary oligosaccharides (including sialylated and non-core fucosylated glycans). The linkages of sialic acid and the branched fucose were analysed by digestion with linkage-specific enzymes and subsequent separation by electrophoresis. All data were consistent with the presence of sLe(x) moieties on the N-linked oligosaccharides of sCR1sLe(x). sCR1sLe(x) is a prime example of a recombinant protein expressed with oligosaccharides engineered for a specific biological function, and produced using a commercially viable method.

  3. Investigation of intravalence, core-valence and core-core electron correlation effects in polonium atomic structure calculations

    NASA Astrophysics Data System (ADS)

    Quinet, Pascal

    2014-09-01

    A detailed investigation of the atomic structure and radiative parameters involving the lowest states within the 6p4, 6p36d, 6p37s, 6p37p and 6p37d configurations of neutral polonium is reported in the present paper. Using different physical models based on the pseudo-relativistic Hartree-Fock approach, the influence of intravalence, core-valence and core-core electron correlation on the atomic parameters is discussed in detail. This work allowed us to fix the spectroscopic designation of some experimental level energy values and to provide for the first time a set of reliable oscillator strengths corresponding to 31 Po I spectral lines in the wavelength region from 175 to 987 nm.

  4. Selenium semiconductor core optical fibers

    SciTech Connect

    Tang, G. W.; Qian, Q. Peng, K. L.; Wen, X.; Zhou, G. X.; Sun, M.; Chen, X. D.; Yang, Z. M.

    2015-02-15

    Phosphate glass-clad optical fibers containing selenium (Se) semiconductor core were fabricated using a molten core method. The cores were found to be amorphous as evidenced by X-ray diffraction and corroborated by Micro-Raman spectrum. Elemental analysis across the core/clad interface suggests that there is some diffusion of about 3 wt % oxygen in the core region. Phosphate glass-clad crystalline selenium core optical fibers were obtained by a postdrawing annealing process. A two-cm-long crystalline selenium semiconductor core optical fibers, electrically contacted to external circuitry through the fiber end facets, exhibit a three times change in conductivity between dark and illuminated states. Such crystalline selenium semiconductor core optical fibers have promising utility in optical switch and photoconductivity of optical fiber array.

  5. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition

    PubMed Central

    Huang, Fu; Saraf, Anita; Florens, Laurence; Kusch, Thomas; Swanson, Selene K.; Szerszen, Leanne T.; Li, Ge; Dutta, Arnob; Washburn, Michael P.; Abmayr, Susan M.; Workman, Jerry L.

    2016-01-01

    KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and are involved in cell cycle regulation. However, information regarding their roles in regulating cell cycle progression is limited. Here, we report the identification of subunits of the Drosophila Enok complex and demonstrate that all subunits are important for its HAT activity. We further report a novel interaction between the Enok complex and the Elg1 proliferating cell nuclear antigen (PCNA)-unloader complex. Depletion of Enok in S2 cells resulted in a G1/S cell cycle block, and this block can be partially relieved by depleting Elg1. Furthermore, depletion of Enok reduced the chromatin-bound levels of PCNA in both S2 cells and early embryos, suggesting that the Enok complex may interact with the Elg1 complex and down-regulate its PCNA-unloading function to promote the G1/S transition. Supporting this hypothesis, depletion of Enok also partially rescued the endoreplication defects in Elg1-depleted nurse cells. Taken together, our study provides novel insights into the roles of KAT6 HATs in cell cycle regulation through modulating PCNA levels on chromatin. PMID:27198229

  6. Comparison of predicted engine core noise with current and proposed aircraft noise certification requirements

    NASA Technical Reports Server (NTRS)

    Vonglahn, U. H.; Groesbeck, D. E.

    1981-01-01

    Predicted engine core noise levels are compared with measured total aircraft noise levels and with current and proposed federal noise certification requirements. Comparisons are made at the FAR-36 measuring stations and include consideration of both full- and cutback-power operation at takeoff. In general, core noise provides a barrier to achieving proposed EPA stage 5 noise levels for all types of aircraft. More specifically, core noise levels will limit further reductions in aircraft noise levels for current widebody commercial aircraft.

  7. Hollow-Core Fiber Lamp

    NASA Technical Reports Server (NTRS)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

    2016-01-01

    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  8. Sneak in Some Core Subjects

    ERIC Educational Resources Information Center

    Clarke, Lynne

    2011-01-01

    Even if students don't have an aversion to core subjects, they may not see the relationship between the core subjects and their career path. In this article, the author outlines a career path project that can be adapted to work in any career and technical education (CTE) class to highlight the relationship between core subjects and the real world.…

  9. Faculty Supports Communication Core Courses.

    ERIC Educational Resources Information Center

    Kopenhaver, Lillian Lodge; And Others

    1989-01-01

    Asks public relations educators what they think about core classes required for students in their field. Finds they generally support the idea that their students should take core mass communications courses, even if such core courses are developed from a traditional journalism/news-editorial standpoint. (MS)

  10. The relevance of paternity analysis in Romanian population using the D1S80 locus.

    PubMed

    Ceacăreanu, A C; Ceacăreanu, B

    1999-01-01

    At present, DNA fingerprinting for human identification and paternity testing is a necessary and usual procedure. D1S80 is one of the best known polymorphic loci showing a VNTR, and exhibiting a high heterozygosity. This genetic locus, with a Tsp 509 I polymorphism of its 5' flanking sequence (1, 9), have been successfully amplified from human genomic DNA isolated from blood. The Tsp 509 I polymorphism was detected by restriction after PCR amplification. We tested the relevance of paternity analysis using the D1S80 locus considering the allele frequency distribution characteristic for our country. Paternal and maternal bands were compared with the children's DNA patterns. Our data include a comparison between D1S80 alleles amplified from mother, child and the supposed father for three tested families. This study was the first of this type made in Romania. We concluded a good power of discrimination and exclusion for this locus. It can be used successfully in the case of subtypes with low frequencies, and this is frequent for our population because of the high heterozygosity of D1S80 subtypes in Romanian population. We recommend the D1S80 use for exclusion paternity tests in Romanian population, as a very useful molecular tool, but we also recommend a complete set of molecular markers for confirmation paternity test in the same population.

  11. G1/S control of anchorage-independent growth in the fibroblast cell cycle

    PubMed Central

    1991-01-01

    We have developed methodology to identify the block to anchorage- independent growth and position it within the fibroblast cell cycle. Results with NRK fibroblasts show that mitogen stimulation of the G0/G1 transition and G1-associated increases in cell size are minimally affected by loss of cell anchorage. In contrast, the induction of G1/S cell cycle genes and DNA synthesis is markedly inhibited when anchorage is blocked. Moreover, we demonstrate that the anchorage-dependent transition maps to late G1 and shortly before activation of the G1/S p34cdc2-like kinase. The G1/S block was also detectable in NIH-3T3 cells. Our results: (a) distinguish control of cell cycle progression by growth factors and anchorage; (b) indicate that anchorage mediates G1/S control in fibroblasts; and (c) identify a physiologic circumstance in which the phenotype of mammalian cell cycle arrest would closely resemble Saccharomyces cerevisiae START. The close correlation between anchorage independence in vitro and tumorigenicity in vivo emphasizes the key regulatory role for G1/S control in mammalian cells. PMID:1955482

  12. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.

    PubMed

    Deng, Yingfeng; Wang, Zhao V; Tao, Caroline; Gao, Ningguo; Holland, William L; Ferdous, Anwarul; Repa, Joyce J; Liang, Guosheng; Ye, Jin; Lehrman, Mark A; Hill, Joseph A; Horton, Jay D; Scherer, Philipp E

    2013-01-01

    Postprandially, the liver experiences an extensive metabolic reprogramming that is required for the switch from glucose production to glucose assimilation. Upon refeeding, the unfolded protein response (UPR) is rapidly, though only transiently, activated. Activation of the UPR results in a cessation of protein translation, increased chaperone expression, and increased ER-mediated protein degradation, but it is not clear how the UPR is involved in the postprandial switch to alternate fuel sources. Activation of the inositol-requiring enzyme 1 (IRE1) branch of the UPR signaling pathway triggers expression of the transcription factor Xbp1s. Using a mouse model with liver-specific inducible Xbp1s expression, we demonstrate that Xbp1s is sufficient to provoke a metabolic switch characteristic of the postprandial state, even in the absence of caloric influx. Mechanistically, we identified UDP-galactose-4-epimerase (GalE) as a direct transcriptional target of Xbp1s and as the key mediator of this effect. Our results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes.

  13. BECN1s, a short splice variant of BECN1, functions in mitophagy.

    PubMed

    Cheng, Bing; Xu, An; Qiao, Mengran; Wu, Qiao; Wang, Wenyu; Mei, Yide; Wu, Mian

    2015-11-02

    Mitochondria selective autophagy, known as mitophagy, plays a pivotal role in several biological processes, such as elimination of the damaged mitochondria, removal of the mitochondria from immature red blood cells and sperm. The defects in mitophagy are associated with a wide spectrum of human diseases, including neurodegenerative disease, aging, cardiac disease and autoimmune disease. However, the mechanism underlying mitophagy remains largely unclear. Here, we report the characterization of a novel splice variant of BECN1/Beclin 1, BECN1s, which is produced by an alternative splicing mechanism. BECN1s is primarily associated with the outer-membrane of mitochondria. Unlike unspliced BECN1, which is essential for nonselective macroautophagy induction, BECN1s is indispensible for mitochondria-selective autophagy. Furthermore, BECN1s plays an important role in starvation- and membrane depolarization-induced mitophagy. Taken together, our findings broaden the view of BECN1 as an important regulator in autophagy, and implicate BECN1s as a specific mitophagy mediator.

  14. Coring Methane Hydrate by using Hybrid Pressure Coring System of D/V Chikyu

    NASA Astrophysics Data System (ADS)

    Kubo, Y.; Mizuguchi, Y.; Inagaki, F.; Eguchi, N.; Yamamoto, K.

    2013-12-01

    Pressure coring is a technique to keep in-situ conditions in recovering sub-seafloor sediment samples, which are potentially rich in soluble or hydrated gas. In regular core sampling, gas fractions are easily lost through the changes in the pressure and temperature during core recovery, and it has significant impact on the chemical components of the sample. Rapid degassing may also cause critical damages of original structures. To study original characteristics of gaseous sub-seafloor sediment, a new Hybrid Pressure Coring System (Hybrid PCS) was developed for the D/V Chikyu operation by adapting some of the existing pressure sampling technologies. Hybrid PCS is composed of three main parts: top section for the wireline operation, middle section for the accumulator and pressure controlling system, and the bottom section for the autoclave chamber. The design concept is based on that of Pressure Core Sampler used in Ocean Drilling Program, and of Pressure Temperature Core Sampler (PTCS) and Non-cooled PTCS of Japan Oil, Gas and Metals National Corporation (JOGMEC). Several modifications were made including that on the ball valve, which operates to close the autoclave after coring. The core samples are 51 mm in diameter and up to 3.5 m in length. The system is combined with the Extented Shoe Coring System on the Chikyu and best suited for coring of semi-consolidated formation up to about 3400 m from the sea level. Sample autoclave is compatible with Pressure Core Analysis and Transfer System (PCATS) of Geotek Ltd for sub-sampling and analysis under in-situ pressure. The analysis in PCATS includes X-ray CT scan and core logging with P-wave velocity and gamma density. Depressurization provides accurate volume of gas and its sub-sampling. Hybrid PCS was first tested during the Chikyu Exp. 906 at a submarine mud-volcano in the Nankai Trough. A 0.9 m of hydrate rich material was recovered from the summit (water depth: 2000 m) and the intact hydrate structure was observed

  15. Comparing Written Competency in Core French and French Immersion Graduates

    ERIC Educational Resources Information Center

    Lappin-Fortin, Kerry

    2014-01-01

    Few studies have compared the written competency of French immersion students and their core French peers, and research on these learners at a postsecondary level is even scarcer. My corpus consists of writing samples from 255 students from both backgrounds beginning a university course in French language. The writing proficiency of core French…

  16. Curriculum Diversity through a Core Approach to Ethics.

    ERIC Educational Resources Information Center

    Englehardt, Elaine Eliason

    In 1987, a sophomore level interdisciplinary Ethics and Values (EV) core course was implemented at Utah Valley Community College in Orem, serving as the humanities core among the liberal education requirements, a requirement for business students, a vital force in the nursing program, and a means to enrich the trade and technology courses. The…

  17. Properties of iron under core conditions

    NASA Astrophysics Data System (ADS)

    Brown, J. M.

    2003-04-01

    Underlying an understanding of the geodynamo and evolution of the core is knowledge of the physical and chemical properties of iron and iron mixtures under high pressure and temperature conditions. Key properties include the viscosity of the fluid outer core, thermal diffusivity, equations-of-state, elastic properties of solid phases, and phase equilibria for iron and iron-dominated mixtures. As is expected for work that continues to tax technological and intellectual limits, controversy has followed both experimental and theoretical progress in this field. However, estimates for the melting temperature of the inner core show convergence and the equation-of-state for iron as determined in independent experiments and theories are in remarkable accord. Furthermore, although the structure and elastic properties of the solid inner-core phase remains uncertain, theoretical and experimental underpinnings are better understood and substantial progress is likely in the near future. This talk will focus on an identification of properties that are reasonably well known and those that merit further detailed study. In particular, both theoretical and experimental (static and shock wave) determinations of the density of iron under extreme conditions are in agreement at the 1% or better level. The behavior of the Gruneisen parameter (which determines the geothermal gradient and controls much of the outer core heat flux) is constrained by experiment and theory under core conditions for both solid and liquid phases. Recent experiments and theory are suggestive of structure or structures other than the high-pressure hexagonal close-packed (HCP) phase. Various theories and experiments for the elasticity of HCP iron remain in poor accord. Uncontroversial constraints on core chemistry will likely never be possible. However, reasonable bounds are possible on the basis of seismic profiles, geochemical arguments, and determinations of sound velocities and densities at high pressure and

  18. HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells.

    PubMed

    Kubota, Naoko; Inayoshi, Yasutaka; Satoh, Naoko; Fukuda, Takashi; Iwai, Kenta; Tomoda, Hiroshi; Kohara, Michinori; Kataoka, Kazuhiro; Shimamoto, Akira; Furuichi, Yasuhiro; Nomoto, Akio; Naganuma, Akira; Kuge, Shusuke

    2012-07-30

    Hepatitis C virus core protein (Core) contributes to HCV pathogenicity. Here, we demonstrate that Core impairs growth in budding yeast. We identify HSP90 inhibitors as compounds that reduce intracellular Core protein level and restore yeast growth. Our results suggest that HSC90 (Hsc82) may function in the protection of the nascent Core polypeptide against degradation in yeast and the C-terminal region of Core corresponding to the organelle-interaction domain was responsible for Hsc82-dependent stability. The yeast system may be utilized to select compounds that can direct the C-terminal region to reduce the stability of Core protein.

  19. CANOPEN Controller IP Core

    NASA Astrophysics Data System (ADS)

    Caramia, Maurizio; Montagna, Mario; Furano, Gianluca; Winton, Alistair

    2010-08-01

    This paper will describe the activities performed by Thales Alenia Space Italia supported by the European Space Agency in the definition of a CAN bus interface to be used on Exomars. The final goal of this activity is the development of an IP core, to be used in a slave node, able to manage both the CAN bus Data Link and Application Layer totally in hardware. The activity has been focused on the needs of the EXOMARS mission where devices with different computational performances are all managed by the onboard computer through the CAN bus.

  20. Automated Core Design

    SciTech Connect

    Kobayashi, Yoko; Aiyoshi, Eitaro

    2005-07-15

    Multistate searching methods are a subfield of distributed artificial intelligence that aims to provide both principles for construction of complex systems involving multiple states and mechanisms for coordination of independent agents' actions. This paper proposes a multistate searching algorithm with reinforcement learning for the automatic core design of a boiling water reactor. The characteristics of this algorithm are that the coupling structure and the coupling operation suitable for the assigned problem are assumed and an optimal solution is obtained by mutual interference in multistate transitions using multiagents. Calculations in an actual plant confirmed that the proposed algorithm increased the convergence ability of the optimization process.

  1. Hanford coring bit temperature monitor development testing results report

    SciTech Connect

    Rey, D.

    1995-05-01

    Instrumentation which directly monitors the temperature of a coring bit used to retrieve core samples of high level nuclear waste stored in tanks at Hanford was developed at Sandia National Laboratories. Monitoring the temperature of the coring bit is desired to enhance the safety of the coring operations. A unique application of mature technologies was used to accomplish the measurement. This report documents the results of development testing performed at Sandia to assure the instrumentation will withstand the severe environments present in the waste tanks.

  2. Weak decays of J/\\psi and {\\rm{\\Upsilon }}(1S)

    NASA Astrophysics Data System (ADS)

    Wang, Tianhong; Jiang, Yue; Yuan, Han; Chai, Kan; Wang, Guo-Li

    2017-04-01

    In this paper we study the weak decays of J/\\psi and {{\\Upsilon }}(1S). The cases when the final mesons are pseudo-scalars or vectors are considered. Using the Bethe–Salpeter method, we calculate the hadronic transition amplitude and give the form factors. The energy spectra of leptons for the semi-leptonic channels are also presented for convenience. In the calculation of non-leptonic decays, the naive factorization is applied. And all types of such channels, namely, flavor-favored or suppressed and color-favored or suppressed, are calculated. Our results show that, for the semi-leptonic decay modes, the largest branching ratios are of the order of 10‑10 both for J/\\psi and {{\\Upsilon }}(1S) decays, and the largest branching ratios of non-leptonic decays are of the order of 10‑9 for J/\\psi and 10‑10 for {{\\Upsilon }}(1S).

  3. Defective transient endogenous spleen colony formation in S1/S1d mice.

    PubMed

    Wiktor-Jedrzejczak, W; Ahmed, A; Sharkis, S J; McKee, A; Sell, K W

    1979-04-01

    WCB6F1 mice of the genotype S1/S1d did not form transient 5-day endogenous spleen colonies following midlethal irradiation, either spontaneously or in response to postirradiation bleeding. Their hematologically normal (+/+) littermates produced colonies equivalent in number and morphologic type to a normal strain (D2B6F1), as evaluated by both macroscopic and microscopic criteria. Bone marrow cells from S1/S1d mice, when transplanted into lethally irradiated +/+ mice, were able to generate equivalent numbers of transient endogenous spleen colonies (TE-CFUs), as compared to that obtained when syngeneic +/+ marrow cells were injected into lethally irradiated +/+ recipients. A defective growth of an early class of hematopoietic progenitor cells, resulting in the clinical course of the S1/S1d anemia is suggested and confirms previous reports on the microenvironmental nature of this abnormality.

  4. CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

    PubMed Central

    Putz, Eva Maria; Gotthardt, Dagmar; Hoermann, Gregor; Csiszar, Agnes; Wirth, Silvia; Berger, Angelika; Straka, Elisabeth; Rigler, Doris; Wallner, Barbara; Jamieson, Amanda M.; Pickl, Winfried F.; Zebedin-Brandl, Eva Maria; Müller, Mathias; Decker, Thomas; Sexl, Veronika

    2013-01-01

    Summary The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of perforin and granzyme B. Stat1-S727A mice display significantly delayed disease onset in NK cell-surveilled tumor models including melanoma, leukemia, and metastasizing breast cancer. Constitutive phosphorylation of S727 depends on cyclin-dependent kinase 8 (CDK8). Inhibition of CDK8-mediated STAT1-S727 phosphorylation may thus represent a therapeutic strategy for stimulating NK cell-mediated tumor surveillance. PMID:23933255

  5. Optical frequency measurement of the 1S-3S two-photon transition in hydrogen

    NASA Astrophysics Data System (ADS)

    Arnoult, O.; Nez, F.; Julien, L.; Biraben, F.

    2010-11-01

    This article reports the first optical frequency measurement of the 1S-3S transition in hydrogen. The excitation of this transition occurs at a wavelength of 205 nm which is obtained with two frequency doubling stages of a titanium sapphire laser at 820 nm. Its frequency is measured with an optical frequency comb. The second-order Doppler effect is evaluated from the observation of the motional Stark effect due to a transverse magnetic field perpendicular to the atomic beam. The measured value of the 1S_{1/2}( F = 1)-3S1/2( F = 1) frequency splitting is 2 922 742 936.729(13) MHz with a relative uncertainty of 4.5 × 10-12. After the measurement of the 1S-2S frequency, this result is the most precise of the optical frequencies in hydrogen.

  6. Analytical Chemistry Core Capability Assessment - Preliminary Report

    SciTech Connect

    Barr, Mary E.; Farish, Thomas J.

    2012-05-16

    The concept of 'core capability' can be nebulous one. Even at a fairly specific level, where core capability equals maintaining essential services, it is highly dependent upon the perspective of the requestor. Samples are submitted to analytical services because the requesters do not have the capability to conduct adequate analyses themselves. Some requests are for general chemical information in support of R and D, process control, or process improvement. Many analyses, however, are part of a product certification package and must comply with higher-level customer quality assurance requirements. So which services are essential to that customer - just those for product certification? Does the customer also (indirectly) need services that support process control and improvement? And what is the timeframe? Capability is often expressed in terms of the currently utilized procedures, and most programmatic customers can only plan a few years out, at best. But should core capability consider the long term where new technologies, aging facilities, and personnel replacements must be considered? These questions, and a multitude of others, explain why attempts to gain long-term consensus on the definition of core capability have consistently failed. This preliminary report will not try to define core capability for any specific program or set of programs. Instead, it will try to address the underlying concerns that drive the desire to determine core capability. Essentially, programmatic customers want to be able to call upon analytical chemistry services to provide all the assays they need, and they don't want to pay for analytical chemistry services they don't currently use (or use infrequently). This report will focus on explaining how the current analytical capabilities and methods evolved to serve a variety of needs with a focus on why some analytes have multiple analytical techniques, and what determines the infrastructure for these analyses. This information will be

  7. PROCESS FOR JACKETING A CORE

    DOEpatents

    Last, G.A.

    1960-07-19

    A process is given for enclosing the uranium core of a nuclear fuel element by placing the core in an aluminum cup and closing the open end of the cup over the core. As the metal of the cup is brought together in a weld over the center of the end of the core, it is extruded inwardly as internal projection into a central recess in the core and outwardly as an external projection. Thus oxide inclusions in the weld of the cup are spread out into the internal and external projections and do not interfere with the integrity of the weld.

  8. Plasma core reactor applications

    NASA Technical Reports Server (NTRS)

    Latham, T. S.; Rodgers, R. J.

    1976-01-01

    Analytical and experimental investigations were conducted to demonstrate the feasibility of fissioning uranium plasma core reactors and to characterize space and terrestrial applications for such reactors. Uranium hexafluoride fuel is injected into core cavities and confined away from the surface by argon buffer gas injected tangentially from the peripheral walls. Radiant heat transfer calculations were performed for a six-cavity reactor configuration. Axial working fluid channels are located along a fraction of each cavity peripheral wall. Results of calculations for outward-directed radiant energy fluxes corresponding to radiating temperatures of 2000 to 5000 K indicate total operating pressures from 80 to 650 atm, centerline temperatures from 6900 to 30,000 K, and total radiated powers from 25 to 2500 MW, respectively. Applications are described for this type of reactor such as (1) high-thrust, high specific impulse space propulsion, (2) highly efficient systems for generation of electricity, and (3) hydrogen or synthetic fuel production systems using the intense radiant energy fluxes.

  9. NEUTRONIC REACTOR CORE

    DOEpatents

    Thomson, W.B.; Corbin, A. Jr.

    1961-07-18

    An improved core for a gas-cooled power reactor which admits gas coolant at high temperatures while affording strong integral supporting structure and efficient moderation of neutrons is described. The multiplicities of fuel elements constituting the critical amassment of fissionable material are supported and confined by a matrix of metallic structure which is interspersed therebetween. Thermal insulation is interposed between substantially all of the metallic matrix and the fuel elements; the insulation then defines the principal conduit system for conducting the coolant gas in heat-transfer relationship with the fuel elements. The metallic matrix itseif comprises a system of ducts through which an externally-cooled hydrogeneous liquid, such as water, is circulated to serve as the principal neutron moderant for the core and conjointly as the principal coolant for the insulated metallic structure. In this way, use of substantially neutron transparent metals, such as aluminum, becomes possible for the supporting structure, despite the high temperatures of the proximate gas. The Aircraft Nuclear Propulsion program's "R-1" reactor design is a preferred embodiment.

  10. Core-tube data logger

    SciTech Connect

    Henfling, J.A.; Normann, R.A.; Knudsen, S.; Drumheller, D.

    1997-01-01

    Wireline core drilling, increasingly used for geothermal exploration, employs a core-tube to capture a rock core sample during drilling. Three types of core-tube data loggers (CTDL) have been built and tested to date by Sandia national Laboratories. They are: (1) temperature-only logger, (2) temperature/inclinometer logger and (3) heat-shielded temperature/inclinometer logger. All were tested during core drilling operations using standard wireline diamond core drilling equipment. While these tools are designed for core-tube deployment, the tool lends itself to be adapted to other drilling modes and equipment. Topics covered in this paper include: (1) description on how the CTDLs are implemented, (2) the components of the system, (3) the type of data one can expect from this type of tool, (4) lessons learned, (5) comparison to its counterpart and (6) future work.

  11. Models of the earth's core

    NASA Technical Reports Server (NTRS)

    Stevenson, D. J.

    1981-01-01

    Combined inferences from seismology, high-pressure experiment and theory, geomagnetism, fluid dynamics, and current views of terrestrial planetary evolution lead to models of the earth's core with five basic properties. These are that core formation was contemporaneous with earth accretion; the core is not in chemical equilibrium with the mantle; the outer core is a fluid iron alloy containing significant quantities of lighter elements and is probably almost adiabatic and compositionally uniform; the more iron-rich inner solid core is a consequence of partial freezing of the outer core, and the energy release from this process sustains the earth's magnetic field; and the thermodynamic properties of the core are well constrained by the application of liquid-state theory to seismic and labroatory data.

  12. Models of the Earth's Core.

    PubMed

    Stevenson, D J

    1981-11-06

    Combined inferences from seismology, high-pressure experiment and theory, geomagnetism, fluid dynamics, and current views of terrestrial planetary evolution lead to models of the earth's core with the following properties. Core formation was contemporaneous with earth accretion; the core is not in chemical equilibrium with the mantle; the outer core is a fluid iron alloy containing significant quantities of lighter elements and is probably almost adiabatic and compositionally uniform; the more iron-rich inner solid core is a consequence of partial freezing of the outer core, and the energy release from this process sustains the earth's magnetic field; and the thermodynamic properties of the core are well constrained by the application of liquid-state theory to seismic and laboratory data.

  13. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S (Navy designation for the Air Force B-29) launch vehicle (NACA 137) for attachment. In this view the tail of the Skyrocket is almost aligned with the opening cut to fit in the bottom of the P2B-1S. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS). Also partners in the flight research were the Navy-Marine Corps and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service

  14. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S launch vehicle (NACA 137) for attachment. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. Once the D-558-2 was in position, the P2B-1S would be lowered and the attachment made. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds during take-off and landing and in tight turns. The three

  15. Studies of Υ(1S) bottomonium state production at the Tevatron Collider Experiment D0

    SciTech Connect

    Huang, Jundong

    2004-11-01

    The production of heavy quarkonium in hadronic collisions provides an ideal testing ground for our understanding of the production mechanisms for heavy quarks and the non-perturbative QCD effects that bind the quark pairs into quarkonium. In this analysis, the inclusive production cross section of the Υ(1S) bottomonium state is measured using the Υ(1S) → μ+μ- decay mode. The data sample corresponds to an integrated luminosity of 159.1 ± 10.3 pb-1. We determine differential cross sections as functions of the Υ(1S) transverse momentum, pTΥ, for three ranges of the Υ(1S) rapidity: 0 < |yΥ| < 0.6,0.6 < |yΥ| < 1.2 and 1.2 < |yΥ| < 1.8. The shapes of dσ/dpT cross sections show little variation with rapidity and are consistent with the published Run I CDF measurement over the rapidity range |yΥ| < 0.4.

  16. SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection.

    PubMed

    Blanchet, Matthieu; Sureau, Camille; Guévin, Carl; Seidah, Nabil G; Labonté, Patrick

    2015-03-01

    Worldwide, approximately 170 million individuals are afflicted with chronic hepatitis C virus (HCV) infection. To prevent the development of inherent diseases such as cirrhosis and hepatocellular carcinoma, tremendous efforts have been made, leading to the development of promising new treatments. However, their efficiency is still dependent on the viral genotype. Additionally, these treatments that target the virus directly can trigger the emergence of resistant variants. In a previous study, we have demonstrated that a long-term (72h) inhibition of SKI-1/S1P, a master lipogenic pathway regulator through activation of SREBP, resulted in impaired HCV genome replication and infectious virion secretion. In the present study, we sought to investigate the antiviral effect of the SKI-1/S1P small molecule inhibitor PF-429242 at the early steps of the HCV lifecycle. Our results indicate a very potent antiviral effect of the inhibitor early in the viral lifecycle and that the overall action of the compound relies on two different contributions. The first one is SREBP/SKI-1/S1P dependent and involves LDLR and NPC1L1 proteins, while the second one is SREBP independent. Overall, our study confirms that SKI-1/S1P is a relevant target to impair HCV infection and that PF-429242 could be a promising candidate in the field of HCV infection treatment.

  17. Recognition of disturbances with specified morphology in time series: Part 2. Spikes on 1-s magnetograms

    NASA Astrophysics Data System (ADS)

    Soloviev, A. A.; Agayan, S. M.; Gvishiani, A. D.; Bogoutdinov, Sh. R.; Chulliat, A.

    2012-05-01

    Preliminary magnetograms contain different types of temporal anthropogenic disturbances: spikes, baseline jumps, drifts, etc. These disturbances should be identified and filtered out during the preprocessing of the preliminary records for the definitive data. As of now, at the geomagnetic observatories, such filtering is carried out manually. Most of the disturbances in the records sampled every second are spikes, which are much more abundant than those on the magnetograms sampled every minute. Another important feature of the 1-s magnetograms is the presence of a plenty of specific disturbances caused by short-period geomagnetic pulsations, which must be retained in the definitive records. Thus, creating an instrument for formalized and unified recognition of spikes on the preliminary 1-s magnetograms would largely solve the problem of labor-consuming manual preprocessing of the magnetic records. In the context of this idea, in the present paper, we focus on recognition of the spikes on the 1-s magnetograms as a key point of the problem. We describe here the new algorithm of pattern recognition, SPs, which is capable of automatically identifying the spikes on the 1-s magnetograms with a low probability of missed events and false alarms. The algorithm was verified on the real magnetic data recorded at the French observatory located on Easter Island in the Pacific.

  18. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes remain unclear. Here we show that induction ofthe unfolded protein response transcription factor spliced X-box binding protein 1(Xbp1s) in pro-opio-melanocortin (Pomc) neurons alone is sufficient to pr...

  19. Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid

    DOEpatents

    Silverman, Richard B; Dewey, Stephen L; Miller, Steven

    2015-03-03

    (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).

  20. 3. N ELEVATION OF BUILDING 1'S E WING, SHOWING THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. N ELEVATION OF BUILDING 1'S E WING, SHOWING THE PILASTERS, TERRA COTTA PANELS, AND THE EGYPTIAN MOTIF DECORATIVE CORNICE ELEMENTS; LOOKING S. (Ryan) - Veterans Administration Medical Center, Building No. 1, Old State Route 13 West, Marion, Williamson County, IL

  1. 4. DETAIL VIEW OF NW CORNER OF BUILDING 1'S W ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. DETAIL VIEW OF NW CORNER OF BUILDING 1'S W WING, SHOWING THE PILASTERS, TERRA COTTA PANELS, AND THE EGYPTIAN MOTIF DECORATIVE CORNICE ELEMENTS; LOOKING ENE. (Harms) - Veterans Administration Medical Center, Building No. 1, Old State Route 13 West, Marion, Williamson County, IL

  2. NEUTRONIC REACTOR CORE INSTRUMENT

    DOEpatents

    Mims, L.S.

    1961-08-22

    A multi-purpose instrument for measuring neutron flux, coolant flow rate, and coolant temperature in a nuclear reactor is described. The device consists essentially of a hollow thimble containing a heat conducting element protruding from the inner wall, the element containing on its innermost end an amount of fissionsble materinl to function as a heat source when subjected to neutron flux irradiation. Thermocouple type temperature sensing means are placed on the heat conducting element adjacent the fissionable material and at a point spaced therefrom, and at a point on the thimble which is in contact with the coolant fluid. The temperature differentials measured between the thermocouples are determinative of the neutron flux, coolant flow, and temperature being measured. The device may be utilized as a probe or may be incorporated in a reactor core. (AE C)

  3. Growth outside the core.

    PubMed

    Zook, Chris; Allen, James

    2003-12-01

    Growth in an adjacent market is tougher than it looks; three-quarters of the time, the effort fails. But companies can change those odds dramatically. Results from a five-year study of corporate growth conducted by Bain & Company reveal that adjacency expansion succeeds only when built around strong core businesses that have the potential to become market leaders. And the best place to look for adjacency opportunities is inside a company's strongest customers. The study also found that the most successful companies were able to consistently, profitably outgrow their rivals by developing a formula for pushing out the boundaries of their core businesses in predictable, repeatable ways. Companies use their repeatability formulas to expand into any number of adjacencies. Some companies make repeated geographic moves, as Vodafone has done in expanding from one geographic market to another over the past 13 years, building revenues from $1 billion in 1990 to $48 billion in 2003. Others apply a superior business model to new segments. Dell, for example, has repeatedly adapted its direct-to-customer model to new customer segments and new product categories. In other cases, companies develop hybrid approaches. Nike executed a series of different types of adjacency moves: it expanded into adjacent customer segments, introduced new products, developed new distribution channels, and then moved into adjacent geographic markets. The successful repeaters in the study had two common characteristics. First, they were extraordinarily disciplined, applying rigorous screens before they made an adjacency move. This discipline paid off in the form of learning curve benefits, increased speed, and lower complexity. And second, in almost all cases, they developed their repeatable formulas by studying their customers and their customers' economics very, very carefully.

  4. Cibotium barometz polysaccharides stimulate chondrocyte proliferation in vitro by promoting G1/S cell cycle transition.

    PubMed

    Fu, Changlong; Zheng, Chunsong; Lin, Jie; Ye, Jinxia; Mei, Yangyang; Pan, Caibin; Wu, Guangwen; Li, Xihai; Ye, Hongzhi; Liu, Xianxiang

    2017-03-30

    Cibotium barometz polysaccharides (CBPS) are one of the most important bioactive components extracted from the Cibotium barometz plant, which belongs to the Dicksoniaceae family. It has been widely used for the treatment of orthopedic diseases in traditional Chinese medicine. However, the molecular mechanisms behind the therapeutic effects of CBPS remain to be clarified. In the present study, the concentration of CBPS was detected by phenol-vitriol colorimetry. Furthermore, the effects stimulated by CBPS on the viability and G1/S cell cycle transition in primary chondrocytes from Sprague-Dawley rats were investigated. A cell viability assay demonstrated that chondrocyte proliferation may be enhanced by CBPS in a dose‑ and time‑dependent manner. The mechanism underlying the promotion of chondrocyte cell cycle was suggested to involve the stimulation of G1 to S phase transition. To further confirm the results, reverse transcription‑quantitative polymerase chain reaction and western blot analyses were used to detect the expression of mRNA and protein levels of cyclin D1, cyclin‑dependent kinase 4 and retinoblastoma protein. The results suggested that CBPS may stimulate chondrocyte proliferation via promoting G1/S cell cycle transition. Since osteoarthritis is characterized by deficient proliferation in chondrocytes, the present study indicates that CBPS may potentially serve as a novel method for the treatment of osteoarthritis.

  5. Search for radiative decays of {upsilon}(1S) into {eta} and {eta}'

    SciTech Connect

    Athar, S. B.; Patel, R.; Potlia, V.; Stoeck, H.; Yelton, J.; Rubin, P.; Cawlfield, C.; Eisenstein, B. I.; Karliner, I.; Kim, D.; Lowrey, N.; Naik, P.; Sedlack, C.; Selen, M.; White, E. J.; Wiss, J.; Shepherd, M. R.; Besson, D.; Pedlar, T. K.; Cronin-Hennessy, D.

    2007-10-01

    We report on a search for the radiative decay of {upsilon}(1S) to the pseudoscalar mesons {eta} and {eta}{sup '} in (21.2{+-}0.2)x10{sup 6} {upsilon}(1S) decays collected with the CLEO III detector at the Cornell Electron Storage Ring. The {eta} meson was reconstructed in the three modes {eta}{yields}{gamma}{gamma}, {eta}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0}, or {eta}{yields}{pi}{sup 0}{pi}{sup 0}{pi}{sup 0}. The {eta}{sup '} meson was reconstructed in the mode {eta}{sup '}{yields}{pi}{sup +}{pi}{sup -}{eta} with {eta} decaying through any of the above three modes, and also {eta}{sup '}{yields}{gamma}{rho}{sup 0}, where {rho}{sup 0}{yields}{pi}{sup +}{pi}{sup -}. Five out of the seven submodes are found to have very low backgrounds. In four of them we find no signal candidates and in one [{upsilon}(1S){yields}{gamma}{eta}{sup '}, {eta}{sup '}{yields}{pi}{sup +}{pi}{sup -}{eta}, {eta}{yields}{pi}{sup +}{pi}{sup -}{pi}{sup 0}] there are two good signal candidates, which is insufficient evidence to claim a signal. The other two submodes ({eta}{yields}{gamma}{gamma} and {eta}{sup '}{yields}{gamma}{rho}) are background limited, and show no excess of events in their signal regions. We combine the results from different channels and obtain upper limits at the 90% C.L. which are B({upsilon}(1S){yields}{gamma}{eta})<1.0x10{sup -6} and B({upsilon}(1S){yields}{gamma}{eta}{sup '})<1.9x10{sup -6}. Our limits are an order of magnitude tighter than the previous ones and below the predictions made by some theoretical models.

  6. 76 FR 63316 - Prospective Grant of Exclusive License: Secreted Frizzled Related Protein-1 (sFRP-1) and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... Prospective Grant of Exclusive License: Secreted Frizzled Related Protein-1 (sFRP-1) and derivatives thereof... a protein designated secreted Frizzled Related Protein-1 (sFRP-1). sFRP-1, also known as SARP-2 (Secreted Apoptosis Related Protein-2). The IP covers various sFRP-1 compositions and uses thereof....

  7. Robustness of CDK2 in Triggering Cellular Senescence based on Probability of DNA-damaged Cells Passing G1/S Checkpoint

    NASA Astrophysics Data System (ADS)

    Ling, Hong; Samarasinghe, Sandhya; Kulasiri, Don

    2011-06-01

    Recent experiments have shown that cellular senescence, a mechanism employed by cells for thwarting cell proliferation, plays an important role in protecting cells against cancer; therefore, a deeper understanding of cellular senescence can lead to effective cancer treatment. Inhibition of CDK2 is thought to be the critical trigger for cellular senescence. In this study, we first implement a mathematical model of G1/S transition involving the DNA-damage pathway and show that cellular senescence can be achieved by lowering CDK2. The robustness of CDK2 in triggering cellular senescence is determined from the probability (β) of DNA-damaged cells passing G1/S checkpoint for normal CDK2 and CDK2-deficient situations based on different thresholds of the peak time of two important biomarkers, CycE and E2F. The comparison of the values of β under the normal CDK2 and lower CDK2 levels reveals that reducing CDK2 levels can decrease the percentage of damaged cells passing G1/S checkpoint; more importantly, 50% reduction of CDK2 achieves 65% reduction in the percentage of damaged cells passing the G1/S checkpoint. These results point out that the developed model can highlight the possibility of lowering the bar for cellular senescence by reducing CDK2 levels. The results of investigation of β for the different thresholds of the peak times of other biomarkers show that β is insensitive to these perturbations of the peak time indicating that CDK2 activity is robust in lowering the senescence bar for low and high levels of DNA-damage. Furthermore, a mathematical formulation of robustness indicates that the robustness of CDK2-triggered senescence increases with decreasing levels of CDK2, and is slightly greater for low-level DNA damage condition.

  8. Related Core Academic Knowledge and Skills. Georgia Core Standards for Occupational Clusters.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Dept. of Occupational Studies.

    This document lists the industry-identified core academic knowledge and skills that should be possessed by all Georgia students who are enrolled in occupational cluster programs and are preparing to enter the work force or continue their occupational specialization at the postsecondary level. First, 63 related communications competencies are…

  9. GPM Core Observatory Launch Animation

    NASA Video Gallery

    This animation depicts the launch of the Global Precipitation Measurement (GPM) Core Observatory satellite from Tanegashima Space Center, Japan. The launch is currently scheduled for Feb. 27, 2014....

  10. Prognostic value of soluble intercellular adhesion molecule-1 (s-ICAM-1) in HIV-infected children.

    PubMed

    Gaddi, E; Laucella, S; Balbaryski, J; Cantisano, C; Barboni, G; Candi, M; Giraudi, V

    2000-12-01

    Central events in the host defence system and immune-mediated damage are tightly regulated by cell adhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided into groups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied to detect the presence of soluble intercellular adhesion molecule-1 (s-ICAM-1). Soluble ICAM-1 levels were found to be significantly increased in HIV-infected children in comparison with SR children or healthy controls. Levels of soluble ICAM-1 were higher in patients with severe forms of HIV-infection than in those with a milder form of the disease. Significant differences in titers of s-ICAM-1 were recorded between SR children and HIV-infected children with mild disease or healthy controls. There was a significant correlation between s-ICAM-1 levels and the concentrations of beta 2 microglobulin (beta 2m) and, to a lesser extend, immunoglobulin A levels (IgA). Soluble ICAM-1 levels didn't change considerably in HIV-infected children in stable clinical conditions, independently of their clinical stage of the disease, during a follow-up period of 9-12 months. Conversely, s-ICAM-1 levels increased simultaneously with the appearance of new well-defined clinical disorders or decreased during the improvement of clinical conditions. A significant negative correlation was recorded between the titers of the s-ICAM-1 and the CD4(+) T-cell levels. These results suggest that the s-ICAM-1 might be another useful tool to evaluate disease progression.

  11. IN-CORE FUEL MANAGEMENT: PWR Core Calculations Using MCRAC

    NASA Astrophysics Data System (ADS)

    PetroviĆ, B. G.

    1991-01-01

    The following sections are included: * INTRODUCTION * IN-CORE FUEL MANAGEMENT CALCULATIONS * In-Core Fuel Management * Methodological Problems of In-Core Fuel Management * In-Core Fuel Management Analytical Tools * PENN STATE FUEL MANAGEMENT PACKAGE * Penn State Fuel Management Package (PFMP) * Assembly Data Description (ADD) * Linking PSU-LEOPARD and MCRAC: An Example * MULTICYCLE REACTOR ANALYSIS CODE (MCRAC) * Main Features and Options of MCRAC code * Core geometry * Diffusion equations * 1.5-group model * Multicycle neutronic analysis * Multicycle cost analysis * Criticality search * Power-dependent xenon feedback calculations * Control rod and burnable absorber simulation * Search for LP with flat BOC power distribution * Artificial ADD option * Variable dimensioning technique * RBI version of MCRAC code * Programming changes in PC version * Fuel interchange option * MCRAC Input/Output * General input description * Sample input * Sample output * EXPERIENCE WITH MCRAC CODE * CONCLUSIONS * REFERENCES

  12. Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin–1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model

    PubMed Central

    Wang, Qiwei; Zhou, Ting; Liu, Zhenjie; Ren, Jun; Phan, Noel; Gupta, Kartik; Stewart, Danielle M.; Morgan, Stephanie; Assa, Carmel; Kent, K. Craig; Liu, Bo

    2017-01-01

    Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment to effectively slow aneurysm growth or prevent rupture. Necroptosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently demonstrated that the lack of RIP3 in mice prevented aneurysm formation. The goal of the current study is to test whether perturbing necroptosis affects progression of existing aneurysm using the RIP1 inhibitors Necrostatin-1 (Nec-1) and an optimized form of Nec-1, 7-Cl-O-Nec-1 (Nec-1s). Seven days after aneurysm induction by elastase perfusion, mice were randomly administered DMSO, Nec-1 (3.2 mg/kg/day) and Nec-1s (1.6 mg/kg/day) via intraperitoneal injection. Upon sacrifice on day 14 postaneurysm induction, the aortic expansion in the Nec-1s group (64.12 ± 4.80%) was significantly smaller than that of the DMSO group (172.80 ± 13.68%) (P < 0.05). The mean aortic diameter of Nec-1 treated mice appeared to be smaller (121.60 ± 10.40%) than the DMSO group, though the difference was not statistically significant (P = 0.1). Histologically, the aortic structure of Nec-1s-treated mice appeared normal, with continuous and organized elastin laminae and abundant αActin-expressing SMCs. Moreover, Nect-1s treatment diminished macrophage infiltration and MMP9 accumulation and increased aortic levels of tropoelastin and lysyl oxidase. Together, our data suggest that pharmacological inhibition of necroptosis with Nec-1s stabilizes pre-existing aneurysms by diminishing inflammation and promoting connective tissue repair. PMID:28186202

  13. Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model.

    PubMed

    Wang, Qiwei; Zhou, Ting; Liu, Zhenjie; Ren, Jun; Phan, Noel; Gupta, Kartik; Stewart, Danielle M; Morgan, Stephanie; Assa, Carmel; Kent, K Craig; Liu, Bo

    2017-02-10

    Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment to effectively slow aneurysm growth or prevent rupture. Necroptosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently demonstrated that the lack of RIP3 in mice prevented aneurysm formation. The goal of the current study is to test whether perturbing necroptosis affects progression of existing aneurysm using the RIP1 inhibitors Necrostatin-1 (Nec-1) and an optimized form of Nec-1, 7-Cl-O-Nec-1 (Nec-1s). Seven days after aneurysm induction by elastase perfusion, mice were randomly administered DMSO, Nec-1 (3.2 mg/kg/day) and Nec-1s (1.6 mg/kg/day) via intraperitoneal injection. Upon sacrifice on day 14 postaneurysm induction, the aortic expansion in the Nec-1s group (64.12 ± 4.80%) was significantly smaller than that of the DMSO group (172.80 ± 13.68%) (P < 0.05). The mean aortic diameter of Nec-1 treated mice appeared to be smaller (121.60 ± 10.40%) than the DMSO group, though the difference was not statistically significant (P = 0.1). Histologically, the aortic structure of Nec-1s-treated mice appeared normal, with continuous and organized elastin laminae and abundant αActin-expressing SMCs. Moreover, Nect-1s treatment diminished macrophage infiltration and MMP9 accumulation and increased aortic levels of tropoelastin and lysyl oxidase. Together, our data suggest that pharmacological inhibition of necroptosis with Nec-1s stabilizes pre-existing aneurysms by diminishing inflammation and promoting connective tissue repair.

  14. The superstring, DiffS/sup 1//S/sup 1/, and holomorphic geometry

    SciTech Connect

    Harari, D.; Hong, Deog Ki; Ramond, P.; Rodgers, V.G.J.

    1987-04-01

    We incorporate superstrings into the non-perturbative formulation of string field theories based on Kahler geometry recently proposed by Bowick and Rajeev. The string field is conjectured to be the Kahler potential of loop space, its equation of motion given by the vanishing of the curvature of a product bundle constructed over a graded DiffS/sup 1//S/sup 1/, as required for reparametrization invariance of the theory. We find that bosonic and fermionic loops in a Minkowski background solve the equation for the Kahler potential only in ten dimensions. We use geometric quantization techniques to calculate the curvature of the superholomorphic vector bundle, since they emphasize the role of the complex geometry, and flag manifold techniques to calculate the curvature of the line bundle over SuperDiffS/sup 1//S/sup 1/.

  15. Measurement of the t dependence in exclusive photoproduction of ϒ(1S) mesons at HERA

    NASA Astrophysics Data System (ADS)

    ZEUS Collaboration; Abramowicz, H.; Abt, I.; Adamczyk, L.; Adamus, M.; Aggarwal, R.; Antonelli, S.; Antonioli, P.; Antonov, A.; Arneodo, M.; Aushev, V.; Aushev, Y.; Bachynska, O.; Bamberger, A.; Barakbaev, A. N.; Barbagli, G.; Bari, G.; Barreiro, F.; Bartosik, N.; Bartsch, D.; Basile, M.; Behnke, O.; Behr, J.; Behrens, U.; Bellagamba, L.; Bertolin, A.; Bhadra, S.; Bindi, M.; Blohm, C.; Bokhonov, V.; Bołd, T.; Bondarenko, K.; Boos, E. G.; Borras, K.; Boscherini, D.; Bot, D.; Brock, I.; Brownson, E.; Brugnera, R.; Brümmer, N.; Bruni, A.; Bruni, G.; Brzozowska, B.; Bussey, P. J.; Bylsma, B.; Caldwell, A.; Capua, M.; Carlin, R.; Catterall, C. D.; Chekanov, S.; Chwastowski, J.; Ciborowski, J.; Ciesielski, R.; Cifarelli, L.; Cindolo, F.; Contin, A.; Cooper-Sarkar, A. M.; Coppola, N.; Corradi, M.; Corriveau, F.; Costa, M.; D'Agostini, G.; Dal Corso, F.; del Peso, J.; Dementiev, R. K.; De Pasquale, S.; Derrick, M.; Devenish, R. C. E.; Dobur, D.; Dolgoshein, B. A.; Dolinska, G.; Doyle, A. T.; Drugakov, V.; Durkin, L. S.; Dusini, S.; Eisenberg, Y.; Ermolov, P. F.; Eskreys, A.; Fang, S.; Fazio, S.; Ferrando, J.; Ferrero, M. I.; Figiel, J.; Forrest, M.; Foster, B.; Gach, G.; Galas, A.; Gallo, E.; Garfagnini, A.; Geiser, A.; Gialas, I.; Gladilin, L. K.; Gladkov, D.; Glasman, C.; Gogota, O.; Golubkov, Yu. A.; Göttlicher, P.; Grabowska-Bołd, I.; Grebenyuk, J.; Gregor, I.; Grigorescu, G.; Grzelak, G.; Gueta, O.; Guzik, M.; Gwenlan, C.; Haas, T.; Hain, W.; Hamatsu, R.; Hart, J. C.; Hartmann, H.; Hartner, G.; Hilger, E.; Hochman, D.; Hori, R.; Horton, K.; Hüttmann, A.; Ibrahim, Z. A.; Iga, Y.; Ingbir, R.; Ishitsuka, M.; Jakob, H.-P.; Januschek, F.; Jones, T. W.; Jüngst, M.; Kadenko, I.; Kahle, B.; Kananov, S.; Kanno, T.; Karshon, U.; Karstens, F.; Katkov, I. I.; Kaur, M.; Kaur, P.; Keramidas, A.; Khein, L. A.; Kim, J. Y.; Kisielewska, D.; Kitamura, S.; Klanner, R.; Klein, U.; Koffeman, E.; Kooijman, P.; Korol, Ie.; Korzhavina, I. A.; Kotański, A.; Kötz, U.; Kowalski, H.; Kuprash, O.; Kuze, M.; Lee, A.; Levchenko, B. B.; Levy, A.; Libov, V.; Limentani, S.; Ling, T. Y.; Lisovyi, M.; Lobodzinska, E.; Lohmann, W.; Löhr, B.; Lohrmann, E.; Long, K. R.; Longhin, A.; Lontkovskyi, D.; Lukina, O. Yu.; Maeda, J.; Magill, S.; Makarenko, I.; Malka, J.; Mankel, R.; Margotti, A.; Marini, G.; Martin, J. F.; Mastroberardino, A.; Mattingly, M. C. K.; Melzer-Pellmann, I.-A.; Mergelmeyer, S.; Miglioranzi, S.; Mohamad Idris, F.; Monaco, V.; Montanari, A.; Morris, J. D.; Mujkic, K.; Musgrave, B.; Nagano, K.; Namsoo, T.; Nania, R.; Nigro, A.; Ning, Y.; Nobe, T.; Noor, U.; Notz, D.; Nowak, R. J.; Nuncio-Quiroz, A. E.; Oh, B. Y.; Okazaki, N.; Oliver, K.; Olkiewicz, K.; Onishchuk, Yu.; Papageorgiu, K.; Parenti, A.; Paul, E.; Pawlak, J. M.; Pawlik, B.; Pelfer, P. G.; Pellegrino, A.; Perlański, W.; Perrey, H.; Piotrzkowski, K.; Pluciński, P.; Pokrovskiy, N. S.; Polini, A.; Proskuryakov, A. S.; Przybycień, M.; Raval, A.; Reeder, D. D.; Reisert, B.; Ren, Z.; Repond, J.; Ri, Y. D.; Robertson, A.; Roloff, P.; Rubinsky, I.; Ruspa, M.; Sacchi, R.; Salii, A.; Samson, U.; Sartorelli, G.; Savin, A. A.; Saxon, D. H.; Schioppa, M.; Schlenstedt, S.; Schleper, P.; Schmidke, W. B.; Schneekloth, U.; Schönberg, V.; Schörner-Sadenius, T.; Schwartz, J.; Sciulli, F.; Shcheglova, L. M.; Shehzadi, R.; Shimizu, S.; Singh, I.; Skillicorn, I. O.; Słomiński, W.; Smith, W. H.; Sola, V.; Solano, A.; Son, D.; Sosnovtsev, V.; Spiridonov, A.; Stadie, H.; Stanco, L.; Stern, A.; Stewart, T. P.; Stifutkin, A.; Stopa, P.; Suchkov, S.; Susinno, G.; Suszycki, L.; Sztuk-Dambietz, J.; Szuba, D.; Szuba, J.; Tapper, A. D.; Tassi, E.; Terrón, J.; Theedt, T.; Tiecke, H.; Tokushuku, K.; Tomalak, O.; Tomaszewska, J.; Tsurugai, T.; Turcato, M.; Tymieniecka, T.; Vázquez, M.; Verbytskyi, A.; Viazlo, O.; Vlasov, N. N.; Volynets, O.; Walczak, R.; Wan Abdullah, W. A. T.; Whitmore, J. J.; Wiggers, L.; Wing, M.; Wlasenko, M.; Wolf, G.; Wolfe, H.; Wrona, K.; Yagües-Molina, A. G.; Yamada, S.; Yamazaki, Y.; Yoshida, R.; Youngman, C.; Żarnecki, A. F.; Zawiejski, L.; Zenaiev, O.; Zeuner, W.; Zhautykov, B. O.; Zhmak, N.; Zhou, C.; Zichichi, A.; Zolkapli, Z.; Zolko, M.; Zotkin, D. S.

    2012-02-01

    The exclusive photoproduction reaction γp→ϒ(1S)p has been studied with the ZEUS detector in ep collisions at HERA using an integrated luminosity of 468 pb. The measurement covers the kinematic range 601S)p cross section.

  16. Business Planning Core Facilities

    PubMed Central

    Itzkowitz, G.N.

    2014-01-01

    Thoughtful business planning is pivotal to the success of any business/operational venture. When planned in a thoughtful and detailed manner there are very few operational or financial surprises for an institution or facility (service center) to contend with. At Stony Brook Medicine we include SWOT analysis and a detailed Market Analysis as part of the process. This is bolstered by an initiative to ensure institutional policies are met so that facilities remain in compliance throughout their lifecycle. As we operate 14 facilities we have had the opportunity to become creative in our approach to coordinate activities, virtualize services, integrate new software business-to-business partners, and finally coordinate plans for phased consolidation instead of outright termination of services when required. As the Associate Dean for Scientific Operations and Research Facilities, the shared research facilities (cores) of the Medical School are in my direct line of sight. We understand their value to the meeting our overall research mission. We have found that an active process of monitoring to predict trouble as much as possible is the best approach for facilities. Some case analysis of this type of interaction will be presented as well.

  17. Adult educators' core competences

    NASA Astrophysics Data System (ADS)

    Wahlgren, Bjarne

    2016-06-01

    Which competences do professional adult educators need? This research note discusses the topic from a comparative perspective, finding that adult educators' required competences are wide-ranging, heterogeneous and complex. They are subject to context in terms of national and cultural environment as well as the kind of adult education concerned (e.g. basic education, work-related education etc.). However, it seems that it is possible to identify certain competence requirements which transcend national, cultural and functional boundaries. This research note summarises these common or "core" requirements, organising them into four thematic subcategories: (1) communicating subject knowledge; (2) taking students' prior learning into account; (3) supporting a learning environment; and (4) the adult educator's reflection on his or her own performance. At the end of his analysis of different competence profiles, the author notes that adult educators' ability to train adult learners in a way which then enables them to apply and use what they have learned in practice (thus performing knowledge transfer) still seems to be overlooked.

  18. Variable depth core sampler

    SciTech Connect

    Bourgeois, P.M.; Reger, R.J.

    1994-12-31

    This invention relates to a sampling means, more particularly to a device to sample hard surfaces at varying depths. Often it is desirable to take samples of a hard surface wherein the samples are of the same diameter but of varying depths. Current practice requires that a full top-to-bottom sample of the material be taken, using a hole saw, and boring a hole from one end of the material to the other. The sample thus taken is removed from the hole saw and the middle of said sample is then subjected to further investigation. This paper describes a variable depth core sampler comprimising a circular hole saw member, having longitudinal sections that collapse to form a point and capture a sample, and a second saw member residing inside the first hole saw member to support the longitudinal sections of the first member and prevent them from collapsing to form a point. The second hole saw member may be raised and lowered inside the the first hole saw member.

  19. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S (Navy designation for the Air Force B-29) launch vehicle (NACA 137) for attachment. In this view the tail of the Skyrocket is almost aligned with the opening cut to fit in the bottom of the P2B-1S. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS). Also partners in the flight research were the Navy-Marine Corps and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service

  20. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S launch vehicle (NACA 137) for attachment. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. Once the D-558-2 was in position, the P2B-1S would be lowered and the attachment made. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds during take-off and landing and in tight turns. The three

  1. D-558-2 being mounted to P2B-1S launch aircraft in hangar

    NASA Technical Reports Server (NTRS)

    1954-01-01

    This 1954 photograph shows a Douglas D-558-2 under the P2B-1S (Navy designation for a B-29) launch aircraft. The P2B-1S has been lifted on mechanical jacks in the hangar for a possible 'fit check' or the attachment of the Skyrocket for a flight. The P2B-1S had the nickname 'Fertile Myrtle.' On the side of its fuselage is a series of images indicating 41 launches by the mothership of D-558-2 #2 (NACA 144) and 44 by D-558-2 #3 (NACA 145). The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and XF-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds

  2. SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells.

    PubMed

    Gao, Zhan; Wang, Hua; Xiao, Feng-Jun; Shi, Xue-Feng; Zhang, Yi-Kun; Xu, Qin Qin; Zhang, Xiao-Yan; Ha, Xiao-Qin; Wang, Li-Sheng

    2016-05-01

    Angiogenesis is one of the most important components of embryonic organ formation and vessel growth after birth. Sphingosine kinase 1 (Sphk1) and S1P has been confirmed to participate in various cell signaling pathways and physiological processes including neovascularisation. However, the mechanisms that Sphk1/S1P regulates neovascularisation remain unclear. In this study, we elucidated that Sphk1/S1P upregulates sirtuin 1 (SIRT1), a NAD+ dependent deacetylases protease which exerts multiple cellular functions, to regulate the proliferation and migration of endothelial cells. By using CCK8 and Transwell assays, we demonstrated that Sphk1 and SIRT1 knockdown could significantly decrease proliferation and migration of HUVEC cells. Sphk1 inhibition results in SIRT1 downregulation which could be reversed by exogenous S1P in HUVEC cells. Treatment of HUVECs with S1P reverses the impaired proliferation and migration caused by SIRT1 knockdown. Furthermore, Sphk1 knockdown inhibits the phosphorylation of P38 MAPK, ERK and AKT. Treatment of HUVECs with PD98059, SB203580 and Wortmannin, which are the inhibitors of ERK, P38 MAPK and AKT respectively, resulted in decreased SIRT1 expression and reduced migration of HUVEC cells. Thus, we conclude that Sphk1/S1P induces SIRT1 upregulation through multiple pathways including P38 MAPK, ERK and AKT signals. This is the first report to disclose the existence and roles of Sphk1/S1P/SIRT1 axis in regulation of endothelial cell proliferation and migration, which may provide a theoretical basis for angiogenesis.

  3. POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking

    PubMed Central

    Schindler, Roland F.R.; Scotton, Chiara; Zhang, Jianguo; Passarelli, Chiara; Ortiz-Bonnin, Beatriz; Simrick, Subreena; Schwerte, Thorsten; Poon, Kar-Lai; Fang, Mingyan; Rinné, Susanne; Froese, Alexander; Nikolaev, Viacheslav O.; Grunert, Christiane; Müller, Thomas; Tasca, Giorgio; Sarathchandra, Padmini; Drago, Fabrizio; Dallapiccola, Bruno; Rapezzi, Claudio; Arbustini, Eloisa; Di Raimo, Francesca Romana; Neri, Marcella; Selvatici, Rita; Gualandi, Francesca; Fattori, Fabiana; Pietrangelo, Antonello; Li, Wenyan; Jiang, Hui; Xu, Xun; Bertini, Enrico; Decher, Niels; Wang, Jun; Brand, Thomas; Ferlini, Alessandra

    2015-01-01

    The Popeye domain–containing 1 (POPDC1) gene encodes a plasma membrane–localized cAMP-binding protein that is abundantly expressed in striated muscle. In animal models, POPDC1 is an essential regulator of structure and function of cardiac and skeletal muscle; however, POPDC1 mutations have not been associated with human cardiac and muscular diseases. Here, we have described a homozygous missense variant (c.602C>T, p.S201F) in POPDC1, identified by whole-exome sequencing, in a family of 4 with cardiac arrhythmia and limb-girdle muscular dystrophy (LGMD). This allele was absent in known databases and segregated with the pathological phenotype in this family. We did not find the allele in a further screen of 104 patients with a similar phenotype, suggesting this mutation to be family specific. Compared with WT protein, POPDC1S201F displayed a 50% reduction in cAMP affinity, and in skeletal muscle from patients, both POPDC1S201F and WT POPDC2 displayed impaired membrane trafficking. Forced expression of POPDC1S201F in a murine cardiac muscle cell line (HL-1) increased hyperpolarization and upstroke velocity of the action potential. In zebrafish, expression of the homologous mutation (popdc1S191F) caused heart and skeletal muscle phenotypes that resembled those observed in patients. Our study therefore identifies POPDC1 as a disease gene causing a very rare autosomal recessive cardiac arrhythmia and LGMD, expanding the genetic causes of this heterogeneous group of inherited rare diseases. PMID:26642364

  4. Complement 1s is the Serine Protease that Cleaves IGFBP-5 in Human Osteoarthritic Joint Fluid

    PubMed Central

    Busby, Walker H.; Yocum, Sue A.; Rowland, Michael; Kellner, Debra; Lazerwith, Scott; Sverdrup, Francis; Yates, Matthew; Radabaugh, Melissa; Clemmons, David R.

    2010-01-01

    Insulin-like growth factor-I (IGF-I) and IGF binding proteins (IGFBPs) are trophic factors for cartilage and have been shown to be chondroprotective in animal models of osteoarthritis. IGFBP-5 is degraded in joint fluid and inhibition of IGFBP-5 degradation has been shown to enhance the trophic effects of IGF-I. Objective To determine the identity of IGFBP-5 protease activity in human osteoarthritic (OA) joint fluid. Method OA joint fluid was purified and the purified material analyzed by IGFBP-5 zymography. Results Both crude joint fluid and purified material contained a single band of proteolytic activity that cleaved IGFBP-5. Immunoblotting of joint fluid for complement 1s (C1s) showed a band that had the same Mr estimate, e.g. 88 kDa. In gel tryptic digestion and subsequent peptide analysis by LC-MS/MS showed that the band contained human complement 1s. A panel of protease inhibitors was tested for their ability to inhibit IGFBP-5 cleavage by the purified protease. Three serine protease inhibitors, FUT175 and CP 143217 and CB-349547 had IC50’s between 1and 6 uM. Two other serine protease inhibitors had intermediate activity (e.g. IC50’s 20–40 uM) and MMP inhibitors had no detectible activity at concentrations up to 300 uM. Conclusion Human OA fluid contains a serine protease that cleaves IGFBP-5. Zymography, immunoblotting and LCMS/MS analysis indicate that complement 1s is the protease that accounts for this activity. PMID:18930415

  5. Resonant inelastic soft x-ray scattering at double core excitations in solid LiCl

    SciTech Connect

    Agaaker, Marcus; Ahuja, Rajeev; Soederstroem, Johan; Rubensson, Jan-Erik; Kaeaembre, Tanel; Glover, Chris; Schmitt, Thorsten; Mattesini, Maurizio

    2006-06-15

    Inelastic soft x-ray scattering in LiCl, resonantly enhanced at states with two Li 1s vacancies, is investigated. States in which both excited electrons are localized during the double core hole lifetime, in which one of the electrons delocalize, as well as triply excited states in which the double core excitation is accompanied by a valence-to-conduction band excitation, contribute to the scattering. The angular momentum symmetry of the involved states and the vibronic coupling during the scattering process are reflected in the angular anisotropy. The effect on the local electronic structure of multiple core holes is theoretically studied by means of supercell band calculations.

  6. Search for Production of Invisible Final States in Single-Photon Decays of Upsilon(1S)

    SciTech Connect

    del Amo Sanchez, P.; Lees, J.P.; Poireau, V.; Prencipe, E.; Tisserand, V.; Garra Tico, J.; Grauges, E.; Martinelli, M.; Milanes, D.A.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Brown, D.N.; Chistiakova, M.V.; Jensen, F.; Kerth, L.T.; Kolomensky, Yu.G.; Lynch, G.; Osipenkov, I.L.; /UC, Berkeley /Birmingham U. /Ruhr U., Bochum /British Columbia U. /Brunel U. /Novosibirsk, IYF /UC, Irvine /UC, Riverside /UC, Santa Barbara /UC, Santa Cruz /Caltech /Cincinnati U. /Colorado U. /Colorado State U. /Dortmund U. /Dresden, Tech. U. /Ecole Polytechnique /Edinburgh U. /INFN, Ferrara /Ferrara U. /INFN, Ferrara /INFN, Ferrara /Ferrara U. /INFN, Ferrara /Frascati /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /INFN, Genoa /INFN, Genoa /Genoa U. /Indian Inst. Tech., Guwahati /Harvard U. /Heidelberg U. /Humboldt U., Berlin /Imperial Coll., London /Iowa State U. /Iowa State U. /Johns Hopkins U. /Orsay, LAL /LLNL, Livermore /Liverpool U. /Queen Mary, U. of London /Royal Holloway, U. of London /Louisville U. /Mainz U., Inst. Kernphys. /Manchester U. /Maryland U. /Massachusetts U., Amherst /MIT /McGill U. /INFN, Milan /Milan U. /INFN, Milan /INFN, Milan /Milan U. /Mississippi U. /Montreal U. /INFN, Naples /Naples U. /NIKHEF, Amsterdam /Notre Dame U. /Ohio State U. /Oregon U. /INFN, Padua /Padua U. /INFN, Padua /INFN, Padua /Padua U. /Paris U., VI-VII /INFN, Perugia /Perugia U. /INFN, Pisa /Pisa U. /INFN, Pisa /Pisa, Scuola Normale Superiore /INFN, Pisa /Pisa U. /INFN, Pisa /Princeton U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /INFN, Rome /INFN, Rome /Rome U. /Rostock U. /Rutherford /DAPNIA, Saclay /SLAC /South Carolina U. /Southern Methodist U. /Stanford U., Phys. Dept. /SUNY, Albany /Tel Aviv U. /Tennessee U. /Texas U. /Texas U., Dallas /INFN, Turin /Turin U. /INFN, Trieste /Trieste U. /Valencia U. /Victoria U. /Warwick U. /Wisconsin U., Madison

    2010-08-25

    We search for single-photon decays of the {Upsilon}(1S) resonance, {Upsilon} {yields} {gamma} + invisible, where the invisible state is either a particle of definite mass, such as a light Higgs boson A{sup 0}, or a pair of dark matter particles, {chi}{bar {chi}}. Both A{sup 0} and {chi} are assumed to have zero spin. We tag {Upsilon}(1S) decays with a dipion transition {Upsilon}(2S) {yields} {pi}{sup +}{pi}{sup -}{Upsilon}(1S) and look for events with a single energetic photon and significant missing energy. We find no evidence for such processes in the mass range m{sub A{sup o}} {le} 9.2GeV and m{sub {chi}} {le} 4.5GeV in the sample of 98 x 10{sup 6} {Upsilon}(2S) decays collected with the BABAR detector and set stringent limits on new physics models that contain light dark matter states.

  7. Determination of the auroral O/1S/ production sources from coordinated rocket and satellite measurements

    NASA Technical Reports Server (NTRS)

    Sharp, W. E.; Torr, D. G.

    1979-01-01

    This paper examines the auroral excitation mechanisms using data collected in a satellite/rocket/aurora coordination. Past theories considered that variation with altitude of the emission from the O(1S) state is the same as that from the N2(+) first negative band system. Actually, the source function for O(1S) does not covary with N2(+) but has a smaller scale height. The covariation is due to quenching of the source function by O(3P). The steadiness of the aurora in a flight of the Michigan Airglow Payload allows the profile to be differentiated for direct comparison with theory. It is concluded that when most of the relevant variables for production of the O(1S) state are simultaneously measured in aurora, the major source functions are dissociative recombination of O2(+) above 210 km to apogee at 250 km, and below 180 km the energy transfer from N2(A3sigma) in the oxygen atom quenching reaction.

  8. Core-to-core uniformity improvement in multi-core fiber Bragg gratings

    NASA Astrophysics Data System (ADS)

    Lindley, Emma; Min, Seong-Sik; Leon-Saval, Sergio; Cvetojevic, Nick; Jovanovic, Nemanja; Bland-Hawthorn, Joss; Lawrence, Jon; Gris-Sanchez, Itandehui; Birks, Tim; Haynes, Roger; Haynes, Dionne

    2014-07-01

    Multi-core fiber Bragg gratings (MCFBGs) will be a valuable tool not only in communications but also various astronomical, sensing and industry applications. In this paper we address some of the technical challenges of fabricating effective multi-core gratings by simulating improvements to the writing method. These methods allow a system designed for inscribing single-core fibers to cope with MCFBG fabrication with only minor, passive changes to the writing process. Using a capillary tube that was polished on one side, the field entering the fiber was flattened which improved the coverage and uniformity of all cores.

  9. Complex decay patterns in atomic core photoionization disentangled by ion-recoil measurements

    SciTech Connect

    Guillemin, Renaud; Bomme, Cedric; Marin, Thierry; Journel, Loic; Marchenko, Tatiana; Kushawaha, Rajesh K.; Piancastelli, Maria Novella; Simon, Marc; Trcera, Nicolas

    2011-12-15

    Following core 1s ionization and resonant excitation of argon atoms, we measure the recoil energy of the ions due to momentum conservation during the emission of Auger electrons. We show that such ion momentum spectroscopy can be used to disentangle to some degree complex decay patterns, involving both radiative and nonradiative decays.

  10. COVERING A CORE BY EXTRUSION

    DOEpatents

    Karnie, A.J.

    1963-07-16

    A method of covering a cylindrical fuel core with a cladding metal ms described. The metal is forced between dies around the core from both ends in two opposing skirts, and as these meet the ends turn outward into an annular recess in the dics. By cutting off the raised portion formed by the recess, oxide impurities are eliminated. (AEC)

  11. Common Core: Victory Is Yours!

    ERIC Educational Resources Information Center

    Fink, Jennifer L. W.

    2012-01-01

    In this article, the author discusses how to implement the Common Core State Standards in the classroom. She presents examples and activities that will leave teachers feeling "rosy" about tackling the new standards. She breaks down important benchmarks and shows how other teachers are doing the Core--and loving it!

  12. Complicated Politics to the Core

    ERIC Educational Resources Information Center

    McGuinn, Patrick

    2015-01-01

    People dislike the Common Core for several different reasons, and so it is important to disaggregate the sources of opposition and to assess and then to dispel some of the myths that have built up around it. It also is important to understand the unusual political alliances that have emerged in opposition to Common Core implementation and how they…

  13. Data interchange across cores of multi-core optical fibers

    NASA Astrophysics Data System (ADS)

    Awad, Ehab S.

    2015-12-01

    A novel device for data interchange among space-division multiplexed cores inside MCF is demonstrated using numerical simulations. The device allows complete exchange of all WDM data channels between MCF cores in propagation direction whether the channels have the same or different sets of wavelengths. This is crucial in future MCF optical networks where in-fiber data interchange over space-division multiplexed cores can allow for a simple and fast data swapping among cores without a need for space-division demultiplexing to single-mode single-core fibers. The data core-interchange (DCI) device consists of a graded refractive-index rectangular waveguide enclosing the two interchanged cores in addition to the cladding region in between them. Both finite-difference-time-domain (FDTD) and eigenmode expansion (EME) simulations are performed to verify the device operation and characterize its performance. The simulations demonstrate that the DCI has a very short-length with polarization independent operation, and high performance over the broadband wavelength range S, C, L, and U bands. Moreover, the device shows a high coupling-factor of -0.13 dB with small cross-talk, back-reflection, and return-loss of -26.3, -46.1, and -48.8 dB, respectively.

  14. Vibroacoustic Characterization of Corrugated-Core and Honeycomb-Core Sandwich Panels

    NASA Technical Reports Server (NTRS)

    Allen, Albert; Schiller, Noah

    2016-01-01

    The vibroacoustic characteristics of two candidate launch vehicle fairing structures, corrugated- core and honeycomb-core sandwich designs, were studied. The study of these structures has been motivated by recent risk reduction efforts focused on mitigating high noise levels within the payload bays of large launch vehicles during launch. The corrugated-core sandwich concept is of particular interest as a dual purpose structure due to its ability to harbor resonant noise control systems without appreciably adding mass or taking up additional volume. Specifically, modal information, wavelength dispersion, and damping were determined from a series of vibrometer measurements and subsequent analysis procedures carried out on two test panels. Numerical and analytical modeling techniques were also used to assess assumed material properties and to further illuminate underlying structural dynamic aspects. Results from the tests and analyses described herein may serve as a reference for additional vibroacoustic studies involving these or similar structures.

  15. Crystallization in Earth's Core after High-Temperature Core Formation

    NASA Astrophysics Data System (ADS)

    Hirose, K.; Morard, G.; Hernlund, J. W.; Helffrich, G. R.; Ozawa, H.

    2015-12-01

    Recent core formation models based on the metal-silicate partitioning of siderophile elements suggest that the Earth's core was formed by metal segregation at high pressure and high temperature in a deep magma ocean. It is also thought that the simultaneous solubility of silicon and oxygen in liquid iron are strongly enhanced at high pressure and high temperature, such that at the end of accretion the core was rich in both silicon and oxygen. Here we performed crystallization experiments on the Fe-Si binary and Fe-Si-O ternary systems up to core pressure in a laser-heated diamond-anvil cell. The starting material for the latter was a homogeneous mixture of fine-grain Fe-Si and SiO2 (<1 µm). We prepared cross sections of samples recovered from the DAC using a focused ion beam (FIB) and subsequently performed textural and chemical characterization with field-emission-type electron microprobe (FE-EPMA). Quenched liquid alloy was found at the hottest part coexisting with a solid phase (liquidus phase) at the periphery. These results combined with literature data on the melting phase relations in the Fe-FeO binary system demonstrate that the liquidus field of SiO2 is very wide at the Fe-rich portion of the Fe-Si-O ternary system at the core pressure range. It indicates that the original Fe-Si-O core liquid should have crystallized a large amount SiO2 until it lost either silicon or oxygen. The recent finding of high thermal conductivity of the core suggests that core thermal convection is difficult to sustain without extreme degrees of secular cooling. However, even for modest degrees of joint Si-O incorporation into the early core, the buoyancy released by crystallization of SiO2 is sufficient to overcome thermal stratification and sustain the geodynamo.

  16. Electronic core level microanalyses and microcopies in multipurpose apparatus.

    PubMed

    Cazaux, J; Gramari, D; Jbara, O; Mouze, D; Nassiopoulos, A; Thomas, X

    1989-03-01

    Using an instrument equipped with two electron guns, an electron analyzer, and a Si(Li) diode detector, we developed microanalytical techniques based on inner-shell electron excitations by incident electrons and X-rays, that is, electron energy-loss spectroscopy (EELS) in the reflection mode; electron probe microanalysis (EPMA) and X-ray appearance potential spectroscopy (XAPS); electron-induced Auger electron spectroscopy (e-AES); X-ray photoelectron spectroscopy (XPS), X-ray absorption spectroscopy (XAS); X-ray induced AES (XAES), X-ray fluorescence analysis (XRF), and scanning X-ray radiography (SXR). The corresponding characteristic images (including X-ray microradiography and X-ray photoelectron microscopy) were obtained in the scanning mode. The principle of the apparatus is described. Each spectroscopy and microscopy is illustrated by an example. Their performance and limits are discussed.

  17. Agitation in Dementia: Relation to Core Cerebrospinal Fluid Biomarker Levels

    PubMed Central

    Bloniecki, Victor; Aarsland, Dag; Cummings, Jeffrey; Blennow, Kaj; Freund-Levi, Yvonne

    2014-01-01

    Background The objective of this study was to examine the associations of agitation with the cerebrospinal fluid dementia biomarkers total-tau (T-tau), phosphorylated-tau (P-tau) and Aβ1-42. Methods One hundred patients (mean age ± SD, 78.6 ± 7.5 years) with dementia and neuropsychiatric symptoms, of whom 67% were female, were included. Agitation was measured using the Cohen-Mansfield Agitation Inventory (CMAI; 46.5 ± 11.8 points). Results Total CMAI correlated with T-tau [rs (31) = 0.36, p = 0.04] and P-tau [rs (31) = 0.35, p = 0.05] in patients with Alzheimer's disease (AD; n = 33) but not in the total dementia population (n = 95). Conclusions Our results suggest that tau-mediated pathology including neurofibrillary tangles and the intensity of the disease process might be associated with agitation in AD. PMID:25298777

  18. Core processing and first analysis of ice cores from Siple and South Pole stations

    SciTech Connect

    Stauffer, B.; Schwander, J.

    1984-01-01

    Analysis of ice cores from the Antarctic allows the authors to study the history of climatic parameters such as temperature, annual accumulation, and atmospheric composition. The main goal of their laboratory analysis of these of these ice cores is to investigate the preindustrial atmospheric carbon dioxide concentration and its natural variations and to measure the carbon-13/carbon-12 ratio in the preindustrial carbon dioxide and in other atmospheric trace gases such as methane. The cores drilled during 1983-1984 field season at the South Pole will be analyzed during the coming year. Several analyses have been made, however, on such cores drilled in the previous field seasons: the analysis of the carbon dioxide concentration of air extracted from ice cores indicates that the preindustrial atmospheric carbon dioxide concentration was about 280 parts per million by volume as compared to present levels of about 340 parts per million. There is some evidence that this value is more accurate than the lower value reported earlier by a laboratory in Grenoble and by their laboratory. They also measured the carbon-13/carbon-12 ratios of carbon dioxide and of the methane concentration. These results are still preliminary and will be reported later.

  19. ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

    PubMed

    Léger, Karolin; Hopp, Ann-Katrin; Fey, Monika; Hottiger, Michael O

    2016-08-02

    ADP-ribosylation is involved in a variety of biological processes, many of which are chromatin-dependent and linked to important functions during the cell cycle. However, any study on ADP-ribosylation and the cell cycle faces the problem that synchronization with chemical agents or by serum starvation and subsequent growth factor addition already activates ADP-ribosylation by itself. Here, we investigated the functional contribution of ARTD1 in cell cycle re-entry and G1/S cell cycle progression using T24 urinary bladder carcinoma cells, which synchronously re-enter the cell cycle after splitting without any additional stimuli. In synchronized cells, ARTD1 knockdown, but not inhibition of its enzymatic activity, caused specific down-regulation of cyclin E during cell cycle re-entry and G1/S progression through alterations of the chromatin composition and histone acetylation, but not of other E2F-1 target genes. Although Cdk2 formed a functional complex with the residual cyclin E, p27(Kip 1) protein levels increased in G1 upon ARTD1 knockdown most likely due to inappropriate cyclin E-Cdk2-induced phosphorylation-dependent degradation, leading to decelerated G1/S progression. These results provide evidence that ARTD1 regulates cell cycle re-entry and G1/S progression via cyclin E expression and p27(Kip 1) stability independently of its enzymatic activity, uncovering a novel cell cycle regulatory mechanism.

  20. Energies, radiative and Auger transitions of the core-excited states for the boron atom

    NASA Astrophysics Data System (ADS)

    Chen, Chao; Sun, Yan; Cong Gou, Bing

    2014-09-01

    Energies, radiative and Auger transitions of the 1s vacancy resonances 1s2s22p2, 1s2s22p3p, 1s2s2p3, 1s2p4, and 1s2p33p, 4L (L=S, P, D) for the neutral boron atom are calculated using the saddle-point variation and saddle-point complex-rotation methods. Large-scale wave functions are used to obtain reliable results. Relativistic and mass polarization corrections are included by the first-order perturbation theory. The calculated term energies, x-ray wavelengths, and Auger electron energies for these core-excited states are compared with available theoretical and experimental results. Auger electron energies and branching ratios are used to identify high-resolution B Auger spectrum produced in 300 keV B+ on CH4 collision experiment. It is found that the Auger decay of core-excited states of the boron atom gives significant contributions to Auger spectrum in the range of 165-210 eV, and many previously unknown line identifications are presented.

  1. Computed microtomography of reservoir core samples

    SciTech Connect

    Coles, M.E.; Muegge, E.L.; Spanne, P.; Jones, K.W.

    1995-03-01

    X-ray computed tomography (CT) is often utilized to evaluate and characterize structural characteristics within reservoir core material systems. Generally, medical CT scanners have been employed because of their availability and ease of use. Of interest lately has been the acquisition of three-dimensional, high resolution descriptions of rock and pore structures for characterization of the porous media and for modeling of single and multiphase transport processes. The spatial resolution of current medical CT scanners is too coarse for pore level imaging of most core samples. Recently developed high resolution computed microtomography (CMT) using synchrotron X-ray sources is analogous to conventional medical CT scanning and provides the ability to obtain three-dimensional images of specimens with a spatial resolution on the order of micrometers. Application of this technique to the study of core samples provides two- and three-dimensional high resolution description of pore structure and mineral distributions. Pore space and interconnectivity is accurately characterized and visualized. Computed microtomography data can serve as input into pore-level simulation techniques. A generalized explanation of the technique is provided, with comparison to conventional CT scanning techniques and results. Computed microtomographic results of several sandstone samples are presented and discussed. Bulk porosity values and mineralogical identification were obtained from the microtomograms and compared with gas porosity and scanning electron microscope results on tandem samples.

  2. Occupied and unoccupied electronic structures of an L-cysteine film studied by core-absorption and resonant photoelectron spectroscopies

    NASA Astrophysics Data System (ADS)

    Kamada, M.; Hideshima, T.; Azuma, J.; Yamamoto, I.; Imamura, M.; Takahashi, K.

    2016-04-01

    Unoccupied and occupied electronic structures of an L-cysteine film have been studied by absorption and resonant photoelectron spectroscopies. Core absorptions at S-L, C-K, N-K, and O-K levels indicate that the lower unoccupied states are predominantly composed of oxygen-2p, carbon-2p, and sulfur-4s+3d orbitals, while higher unoccupied states may be attributed dominantly to nitrogen-np (n ≥ 3), oxygen-np (n ≥ 3), and sulfur-ns+md (n ≥ 4, m ≥ 3) orbitals. Resonant photoelectron spectra at S-L23 and O-K levels indicate that the highest occupied state is originated from sulfur-3sp orbitals, while oxygen-2sp orbitals contribute to the deeper valence states. The delocalization lifetimes of the oxygen-1s and sulfur-2p excited states are estimated from a core-hole clock method to be about 9 ± 1 and 125 ± 25 fs, respectively.

  3. Observation of the ηb(2S) Meson in Υ(2S)→γηb(2S), ηb(2S)→ hadrons and confirmation of the ηb(1S) meson.

    PubMed

    Dobbs, S; Metreveli, Z; Tomaradze, A; Xiao, T; Seth, Kamal K

    2012-08-24

    The data for 9.3 million Υ(2S) and 20.9 million Υ(1S) taken with the CLEO III detector have been used to study the radiative population of states identified by their decay into 26 different exclusive hadronic final states. In the Υ(2S) decays, an enhancement is observed at a ~5σ level at a mass of 9974.6±2.3(stat)±2.1(syst) MeV. It is attributed to η(b)(2S) and corresponds to the Υ(2S) hyperfine splitting of 48.7±2.3(stat)±2.1(syst) MeV. In the Υ(1S) decays, the identification of η(b)(1S) is confirmed at a ~3σ level with M[η(b)(1S)] in agreement with its known value.

  4. Refined genetic mapping of autosomal dominant retinitis pigmentosa locus RP18 reduces the critical region to 2 cM between D1S442 and D1S2858 on chromosome 1q.

    PubMed

    Xu, S Y; Rosenberg, T; Gal, A

    1998-04-01

    Linkage analysis was performed on a large Danish family to refine the position of RP18, the locus for autosomal dominant retinitis pigmentosa, mapped previously between D1S534 and D1S305 in chromosome 1p13-q21. We genotyped the family members for five microsatellite-type DNA polymorphisms and mapped RP18 between D1S422 and D1S2858 to a region of less than 2 cM. No obvious candidate gene has yet been assigned to the chromosomal interval defined here.

  5. HOW STARLESS ARE STARLESS CORES?

    SciTech Connect

    Schnee, Scott; Friesen, Rachel; Di Francesco, James; Johnstone, Doug; Enoch, Melissa; Sadavoy, Sarah

    2012-01-20

    In this paper, we present the results of Combined Array for Research in Millimeter-wave Astronomy continuum and spectral line observations of the dense core Per-Bolo 45. Although this core has previously been classified as starless, we find evidence for an outflow and conclude that Per-Bolo 45 is actually an embedded, low-luminosity protostar. We discuss the impact of newly discovered, low-luminosity, embedded objects in the Perseus molecular cloud on starless core and protostar lifetimes. We estimate that the starless core lifetime has been overestimated by 4%-18% and the Class 0/I protostellar lifetime has been underestimated by 5%-20%. Given the relatively large systematic uncertainties involved in these calculations, variations on the order of 10% do not significantly change either core lifetimes or the expected protostellar luminosity function. Finally, we suggest that high-resolution (sub)millimeter surveys of known cores lacking near-infrared and mid-infrared emission are necessary to make an accurate census of starless cores.

  6. Dynamics of the core, geodynamo

    NASA Astrophysics Data System (ADS)

    Roberts, Paul H.

    1995-07-01

    "The mechanism for generating the geomagnetic field remains one of the central unsolved problems in geoscience." So states the report on the National Geomagnetic Initiative (NGI) prepared by the U.S. Geodynamics Committee, et al [1993], with advice from the NGI Workshop held in Washington D.C. in March 1992. All analyses of the geomagnetic data point to the core as containing the source of the field and "The basic premise that virtually everyone accepts is that the Earth's magnetism is created by a self-sustaining dynamo driven by fluid motions in Earth's core" (NGI, p.135). Dynamical questions at once arise, such as "What is the energy source driving those motions?" Jacobs [1953] proposed that the solid inner core (SIC) is the result of the freezing of the fluid outer core (FOC). Verhoogen [1961] noticed that the release of latent heat at the inner core boundary (ICB) during freezing would help drive thermal convection in the FOC, and Braginsky [1963] pointed out that the release of the light alloying elements during fractionation at the ICB would provide compositional buoyancy. These two sources suffice to supply the geodynamo with energy throughout geological time, even in the absence of dissolved radioactivity in the core [Braginsky and Roberts, 1994a; Kuang et al, 1994]. Stevenson [1991] argues that potential differences on the core-mantle boundary (CMB) of electrochemical origin may be partially responsible for the geomagnetic field.

  7. Simplified cut core inductor design

    NASA Technical Reports Server (NTRS)

    Mclyman, W. T.

    1974-01-01

    Although filter inductor designers have routinely tended to specify molypermalloy powder cores for use in high frequency power converters and pulse-width modulated switching regulators, there are sigificant advantages in specifying C cores and cut toroids fabricated from grain oriented silicon steels which should not be overlooked. Such steel cores can develop flux densities of 1.6 tesla, with useful linearity to 1.2 tesla, whereas molypermalloy cores carrying d.c. current have useful flux density capabilities only to about 0.3 tesla. The use of silicon steel cores thus makes it possible to design more compact cores, and therefore inductors of reduced volume, or conversely to provide greater load capacity in inductors of a given volume. Information is available which makes it possible to obtain quick and close approximations of significant parameters such as size, weight and temperature rise for silicon steel cores for breadboarding. Graphs, nomographs and tables are presented for this purpose, but more complete mathematical derivations of some of the important parameters are also included for a more rigorous treatment.

  8. Systematic review of core muscle activity during physical fitness exercises.

    PubMed

    Martuscello, Jason M; Nuzzo, James L; Ashley, Candi D; Campbell, Bill I; Orriola, John J; Mayer, John M

    2013-06-01

    A consensus has not been reached among strength and conditioning specialists regarding what physical fitness exercises are most effective to stimulate activity of the core muscles. Thus, the purpose of this article was to systematically review the literature on the electromyographic (EMG) activity of 3 core muscles (lumbar multifidus, transverse abdominis, quadratus lumborum) during physical fitness exercises in healthy adults. CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, PubMed, SPORTdiscus, and Web of Science databases were searched for relevant articles using a search strategy designed by the investigators. Seventeen studies enrolling 252 participants met the review's inclusion/exclusion criteria. Physical fitness exercises were partitioned into 5 major types: traditional core, core stability, ball/device, free weight, and noncore free weight. Strength of evidence was assessed and summarized for comparisons among exercise types. The major findings of this review with moderate levels of evidence indicate that lumbar multifidus EMG activity is greater during free weight exercises compared with ball/device exercises and is similar during core stability and ball/device exercises. Transverse abdominis EMG activity is similar during core stability and ball/device exercises. No studies were uncovered for quadratus lumborum EMG activity during physical fitness exercises. The available evidence suggests that strength and conditioning specialists should focus on implementing multijoint free weight exercises, rather than core-specific exercises, to adequately train the core muscles in their athletes and clients.

  9. Effect of coring conditions on temperature rise in bone.

    PubMed

    Islam, Md Monirul; Wang, Xiaodu

    2017-01-01

    Coring is a surgical procedure in bone biopsy retrieval and dental/orthopaedic procedures, which may cause thermal damage to bone tissues adjacent to the coring zone. This study was performed to determine the temperature rise in bone by coring using a semi-empirical thermocouple approach. Concurrently, a custom-made dynamometer was used to measure the cutting and thrust forces during coring bovine cortical bone samples. The experimental results indicated that the cutting force, cutting speed, and depth of cut significantly affect the temperature rise in the cutting zone during coring process. In addition, acute temperature rises in the cutting zone occurred when the cutting speed exceeded threshold levels. The limited capacity of heat dissipation during coring is most likely responsible for such a sharp temperature rise with increasing cutting speed. Moreover, it was observed that the maximum size of potential thermal damage zone could reach to 3.0 mm in depth from the surface of the coring hole, assuming that thermal damage would occur when the temperature is greater than 47°C. Thus, proper cutting conditions need to be selected to avoid the potential thermal damage to bone during the coring procedures.

  10. G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis.

    PubMed

    Giráldez, Servando; Galindo-Moreno, María; Limón-Mortés, M Cristina; Rivas, A Cristina; Herrero-Ruiz, Joaquín; Mora-Santos, Mar; Sáez, Carmen; Japón, Miguel Á; Tortolero, Maria; Romero, Francisco

    2017-03-30

    Polo-like kinase 1 (PLK1) is a serine/threonine kinase involved in several stages of the cell cycle, including the entry and exit from mitosis, and cytokinesis. Furthermore, it has an essential role in the regulation of DNA replication. Together with cyclin A, PLK1 also promotes CDH1 phosphorylation to trigger its ubiquitination and degradation, allowing cell cycle progression. The PLK1 levels in different type of tumors are very high compared to normal tissues, which is consistent with its role in promoting proliferation. Therefore, several PLK1 inhibitors have been developed and tested for the treatment of cancer. Here, we further analyzed PLK1 degradation and found that cytoplasmic PLK1 is ubiquitinated and subsequently degraded by the SCF(βTrCP)/proteasome. This procedure is triggered when heat shock protein (HSP) 90 is inhibited with geldanamycin, which results in misfolding of PLK1. We also identified CDK1 as the major kinase involved in this degradation. Our work shows for the first time that HSP90 inhibition arrests cell cycle progression at the G1/S transition. This novel mechanism inhibits CDH1 degradation through CDK1-dependent PLK1 destruction by the SCF(βTrCP)/proteasome. In these conditions, CDH1 substrates do not accumulate and cell cycle arrests, providing a novel pathway for regulation of the cell cycle at the G1-to-S boundary.-Giráldez, S., Galindo-Moreno, M., Limón-Mortés, M. C., Rivas, A. C., Herrero-Ruiz, J., Mora-Santos, M., Sáez, C., Japón, M. Á., Tortolero, M., Romero, F. G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis.

  11. Downregulated miR-45 Inhibits the G1-S Phase Transition by Targeting Bmi-1 in Breast Cancer

    PubMed Central

    Wang, Lan; Liu, Jun-Ling; Yu, Liang; Liu, Xiang-Xia; Wu, Hong-Mei; Lei, Fang-Yong; Wu, Shu; Wang, Xi

    2015-01-01

    Abstract Bmi-1 (B cell-specific Moloney murine leukemia virus integration site 1) is upregulated in breast cancer and was involved in many malignant progressions of breast cells, including cell proliferation, stem cell pluripotency, and cancer initiation. However, the epigenetic regulatory mechanism of Bmi-1 in breast cancer remains unclear. After analysis of the ArrayExpress dataset GSE45666, we comparatively detected the expression levels of miR-495 in 9 examined breast cancer cell lines, normal breast epithelial cells and 8 pairs of fresh clinical tumor samples. Furthermore, to evaluate the effect of miR-495 on the progression of breast cancer, MCF-7 and MDA-MB-231 were transduced to stably overexpress miR-495. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay, colony formation assays, 5-Bromo-2-deoxyUridine labeling and immunofluorescence, anchorage-independent growth ability assay, flow cytometry analysis, and luciferase assays were used to test the effect of miR-495 in MCF-7 and MDA-MB-231 cells in vitro. Xenografted tumor model was also used to evaluate the effect of miR-495 in breast cancer. Herein, we found that miR-495, a predicted regulator of Bmi-1, was frequently downregulated in malignant cells and tissues of breast. Upregulation of miR-495 significantly suppressed breast cancer cell proliferation and tumorigenicity via G1-S arrest. Further analysis revealed that miR-495 targeted Bmi-1 through its 3′ untranslated region. Moreover, Bmi-1 could neutralize the suppressive effect of miR-495 on cell proliferation and tumorigenicity of breast cancer in vivo. These data suggested that miR-495 could inhibit the G1-S phase transition that leads to proliferation and tumorigenicity inhibition by targeting and suppressing Bmi-1 in breast cancer. PMID:26020378

  12. Core physics analysis of 100% MOX Core in IRIS

    SciTech Connect

    Franceschini, F.; Petrovic, B.

    2006-07-01

    International Reactor Innovative and Secure (IRIS) is an advanced small-to-medium-size (1000 MWt) Pressurized Water Reactor (PWR), targeting deployment around 2015. Its reference core design is based on the current Westinghouse UO{sub 2} fuel with less than 5% {sup 235}U, and the analysis has been previously completed confirming good performance. The full MOX fuel core is currently under evaluation as one of the alternatives for the second wave of IRIS reactors. A full 3-D neutronic analysis has been performed to examine main core performance parameters, such as critical boron concentration, peaking factors, discharge burnup, etc. The enhanced moderation of the IRIS fuel lattice facilitates MOX core design, and all the obtained results are within the requirements, confirming viability of this option from the reactor physics standpoint. (authors)

  13. Core Exercises: Why You Should Strengthen Your Core Muscles

    MedlinePlus

    ... Read on to find out why. Core exercises train the muscles in your pelvis, lower back, hips ... manner that involves maintaining a stable trunk can train and strengthen several of your muscles, including your ...

  14. PNNL Researchers Collect Permafrost Cores in Alaska

    SciTech Connect

    2016-11-23

    Permafrost is ground that is frozen for two or more years. In the Arctic, discontinuous regions of this saturated admixture of soil and rock store a large fraction of the Earth’s carbon – about 1672 petagrams (1672 trillion kilograms). As temperatures increase in the Northern Hemisphere, a lot of that carbon may be released to the atmosphere, making permafrost an important factor to represent accurately in global climate models. At Pacific Northwest National Laboratory, a group led by James C. Stegen periodically extracts permafrost core samples from a site near Fairbanks, Alaska. Back at the lab in southeastern Washington State, they study the cores for levels of microbial activity, carbon fluxes, hydrologic patterns, and other factors that reveal the dynamics of this consequential layer of soil and rock.

  15. Effects of core turbulence on jet excitability

    NASA Technical Reports Server (NTRS)

    Mankbadi, Reda R.; Raman, Ganesh; Rice, Edward J.

    1989-01-01

    The effects of varying freestream core turbulence on the evolution of a circular jet with and without tonal excitation are examined. Measurements are made on an 8.8 cm diameter jet at a Mach number of 0.3. The jet is excitated by plane waves at Strouhal number 0.5. For the excited and unexcited cases the turbulence level is varied by screens and grids placed upstream of the nozzle exit. The experiment results are compared with a theoretical model which incorporates a variable core turbulence and considers the energy interactions between the mean flow, the turbulence and the forced component. Both data and theory indicate that increasing the freestream turbulence diminishes the excitability of the jet and reduces the effect of excitation on the spreading rate of the jet.

  16. On the 1s24d Fine Structures of B III and Ne VIII

    NASA Astrophysics Data System (ADS)

    Wang, Zhiwen; Z, W. Wang; Kwong, T. Chung; Zhu, Xiaowei

    1995-01-01

    The fine structure of lithium-like 1s24d states in the literature behaves irregularly as a function of Z. The fine structures of the B III and Ne VIII fall well below the isoelectronic curve. The term energies of these two systems in the data tables also give worse agreement with the theoretical prediction. In this work, we show that the reason for this unusual situation is caused by a misidentification in the original spectra. When the correct identifications are made, the fine structures of both systems fall on the isoelectronic curve and the agreement between theory and experiment is excellent.

  17. Precision Measurement of the Hydrogen-Deuterium 1S-2S Isotope Shift

    SciTech Connect

    Parthey, Christian G.; Matveev, Arthur; Alnis, Janis; Pohl, Randolf; Udem, Thomas; Kolachevsky, Nikolai; Haensch, Theodor W.; Jentschura, Ulrich D.

    2010-06-11

    Measuring the hydrogen-deuterium isotope shift via two-photon spectroscopy of the 1S-2S transition, we obtain 670 994 334 606(15) Hz. This is a 10-times improvement over the previous best measurement [A. Huber et al., Phys. Rev. Lett. 80, 468 (1998)] confirming its frequency value. A calculation of the difference of the mean square charge radii of deuterium and hydrogen results in {sub d}-{sub p}=3.820 07(65) fm{sup 2}, a more than twofold improvement compared to the former value.

  18. Optical 1's and 2's complement devices using lithium-niobate-based waveguide

    NASA Astrophysics Data System (ADS)

    Pal, Amrindra; Kumar, Santosh; Sharma, Sandeep

    2016-12-01

    Optical 1's and 2's complement devices are proposed with the help of lithium-niobate-based Mach-Zehnder interferometers. It has a powerful capability of switching an optical signal from one port to the other port with the help of an electrical control signal. The paper includes the optical conversion scheme using sets of optical switches. 2's complement is common in computer systems and is used in binary subtraction and logical manipulation. The operation of the circuits is studied theoretically and analyzed through numerical simulations. The truth table of these complement methods is verified with the beam propagation method and MATLAB® simulation results.

  19. Scattering of H(1s) off metastable helium atom at thermal energies

    SciTech Connect

    Sinha, Prabal K.; Ghosh, A. S.

    2006-06-15

    Quantal calculations for scattering of ground-state antihydrogen by metastable (n=2S) helium atoms have been performed using the nonadiabatic, atomic orbital expansion technique at thermal energies. The zero-energy elastic cross sections of the present systems are much greater than the corresponding value for the ground-state helium target. The low-energy elastic cross section for the singlet metastable helium [He(2 {sup 1}S)] target is higher than the corresponding value when the target is in the metastable triplet state [He(2 {sup 3}S)].

  20. Search for very light CP-odd Higgs Boson in radiative decays of Upsilon(1S).

    PubMed

    Love, W; Savinov, V; Mendez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Hu, D; Moziak, B; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Yang, F; Artuso, M; Blusk, S; Khalil, S; Li, J; Mountain, R; Nisar, S; Randrianarivony, K; Sultana, N; Skwarnicki, T; Stone, S; Wang, J C; Zhang, L M; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Reed, J; Briere, R A; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Alexander, J P; Cassel, D G; Duboscq, J E; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Hunt, J M; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Ledoux, J; Mahlke-Krüger, H; Mohapatra, D; Onyisi, P U E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Athar, S B; Patel, R; Yelton, J; Rubin, P; Eisenstein, B I; Karliner, I; Mehrabyan, S; Lowrey, N; Selen, M; White, E J; Wiss, J; Mitchell, R E; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Zweber, P; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Libby, J; Martin, L; Powell, A; Wilkinson, G; Ecklund, K M

    2008-10-10

    We search for a non-SM-like CP-odd Higgs boson (a(1)(0)) decaying to tau(+)tau(-) or mu(+)mu(-) in radiative decays of the Upsilon(1S). No significant signal is found, and upper limits on the product branching ratios are set. Our tau(+)tau(-) results are almost 2 orders of magnitude more stringent than previous upper limits. Our data provide no evidence for a Higgs state with a mass of 214 MeV decaying to mu(+)mu(-), previously proposed as an explanation for 3 Sigma(+)-->pmu(+)mu(-) events observed by the HyperCP experiment. Our results constrain NMSSM models.

  1. Experimental considerations for testing antimatter antigravity using positronium 1S-2S spectroscopy

    NASA Astrophysics Data System (ADS)

    Crivelli, P.; Cooke, D. A.; Friedreich, S.

    2014-05-01

    In this contribution to the WAG 2013 workshop we report on the status of our measurement of the 1S-2S transition frequency of positronium. The aim of this experiment is to reach a precision of 0.5 ppb in order to cross check the QED calculations. After reviewing the current available sources of Ps, we consider laser cooling as a route to push the precision in the measurement down to 0.1 ppb. If such an uncertainty could be achieved, this would be sensitive to the gravitational redshift and therefore be able to assess the sign of gravity for antimatter.

  2. Ultrafast Dynamics in Postcollision Interaction after Multiple Auger Decays in Argon 1s Photoionization

    NASA Astrophysics Data System (ADS)

    Guillemin, R.; Sheinerman, S.; Bomme, C.; Journel, L.; Marin, T.; Marchenko, T.; Kushawaha, R. K.; Trcera, N.; Piancastelli, M. N.; Simon, M.

    2012-07-01

    Argon 1s photoionization followed by multiple Auger decays is investigated both experimentally, by means of photoelectron-ion coincidences, and theoretically. A strong influence of the different Auger decays on the photoelectron spectra is observed through postcollision interaction which shifts the maximum of the energy distribution and distorts the spectral shape. A good agreement between the calculated and measured spectra for selected Arn+ ions (n=1-5) allows one to estimate the widths (lifetimes) of the intermediate states for each specific decay pathway.

  3. Feasibility of coherent xuv spectroscopy on the 1S-2S transition in singly ionized helium

    SciTech Connect

    Herrmann, M.; Saathoff, G.; Gohle, C.; Ozawa, A.; Batteiger, V.; Knuenz, S.; Kolachevsky, N.; Udem, Th.; Haas, M.; Jentschura, U. D.; Kottmann, F.; Leibfried, D.; Schuessler, H. A.; Haensch, T. W.

    2009-05-15

    The 1S-2S two-photon transition in singly ionized helium is a highly interesting candidate for precision tests of bound-state quantum electrodynamics (QED). With the recent advent of extreme ultraviolet frequency combs, highly coherent quasi-continuous-wave light sources at 61 nm have become available, and precision spectroscopy of this transition now comes into reach for the first time. We discuss quantitatively the feasibility of such an experiment by analyzing excitation and ionization rates, propose an experimental scheme, and explore the potential for QED tests.

  4. Nucleon-nucleon scattering in the 1S0 partial wave in the modified Weinberg approach

    NASA Astrophysics Data System (ADS)

    Gasparyan, A. M.; Epelbaum, E.; Gegelia, J.; Krebs, H.

    2016-03-01

    Nucleon-nucleon scattering in the 1S0 partial wave is considered in chiral effective field theory within the recently suggested renormalizable formulation based on the Kadyshevsky equation. Contact interactions are taken into account beyond the leading-order approximation. The subleading contact terms are included non-perturbatively by means of subtractive renormalization. The dependence of the phase shifts on the choice of the renormalization condition is discussed. Perturbative inclusion of the subleading contact interaction is found to be justified only very close to threshold. The low-energy theorems are reproduced significantly better compared with the leading order results.

  5. Preparation and immunogenicity of vaccine Ac NFU1 (S-) MRC towards the prevention of herpes genitalis.

    PubMed Central

    Skinner, G R; Woodman, C B; Hartley, C E; Buchan, A; Fuller, A; Durham, J; Synnott, M; Clay, J C; Melling, J; Wiblin, C; Wilkins, J

    1982-01-01

    A subunit antigenoid vaccine, Ac NFU1 (S-) MRC, was used to prevent primary herpes genitalis in 60 subjects considered to be at risk of this infection. There was no evidence of serious local or general side effects. Neutralising antibody responses were detected in 59% and 90% of subjects receiving the low and high doses of vaccine respectively; immunoprecipitating antibody was detected at a lower frequency, namely in 23% and 43% of subjects receiving the low and high doses respectively. After a mean follow-up period of 18 months none of the vaccinated subjects contracted herpes genitalis after completing the vaccination course. Images PMID:6293640

  6. Preparation and immunogenicity of vaccine Ac NFU1 (S-) MRC towards the prevention of herpes genitalis.

    PubMed

    Skinner, G R; Woodman, C B; Hartley, C E; Buchan, A; Fuller, A; Durham, J; Synnott, M; Clay, J C; Melling, J; Wiblin, C; Wilkins, J

    1982-12-01

    A subunit antigenoid vaccine, Ac NFU1 (S-) MRC, was used to prevent primary herpes genitalis in 60 subjects considered to be at risk of this infection. There was no evidence of serious local or general side effects. Neutralising antibody responses were detected in 59% and 90% of subjects receiving the low and high doses of vaccine respectively; immunoprecipitating antibody was detected at a lower frequency, namely in 23% and 43% of subjects receiving the low and high doses respectively. After a mean follow-up period of 18 months none of the vaccinated subjects contracted herpes genitalis after completing the vaccination course.

  7. Observation of the 1S0 to 3D1 clock transition in 175Lu+

    NASA Astrophysics Data System (ADS)

    Arnold, K. J.; Kaewuam, R.; Roy, A.; Paez, E.; Wang, S.; Barrett, M. D.

    2016-11-01

    We report direct laser spectroscopy of the 1S0 to 3D1 highly-forbidden M1 clock transition in 175Lu+ . Clock operation is demonstrated on three pairs of Zeeman transitions, one pair from each hyperfine manifold of the 3D1 term. We measure the hyperfine intervals of the 3D1 to 10 ppb uncertainty and infer the optical frequency averaged over the three hyperfine transitions to be 353.639 915 952 2 (6 ) THz. The lifetime of the 3D1 state is inferred to be 174-32+23 hours from the M1 coupling strength.

  8. XPS spectra of uranyl minerals and synthetic uranyl compounds. II: The O 1s spectrum

    NASA Astrophysics Data System (ADS)

    Schindler, M.; Hawthorne, F. C.; Freund, M. S.; Burns, P. C.

    2009-05-01

    The O 1s spectrum is examined for 19 uranyl minerals of different composition and structure. Spectra from single crystals were measured with a Kratos Axis Ultra X-ray Photoelectron Spectrometer with a magnetic-confinement charge-compensation system. Well-resolved spectra with distinct maxima, shoulders and inflections points, in combination with reported and measured binding energies for specific O 2- species and structural data of the uranyl minerals are used to resolve the fine structure of the O 1s envelope. The resolution of the O 1s spectra includes, for the first time, different O 2- bands, which are assigned to O atoms linking uranyl with uranyl polyhedra ( Usbnd Osbnd U) and O atoms of uranyl groups ( Odbnd Udbnd O). The resolved bands in the O 1s spectrum occur at distinct ranges in binding energy: bands for ( Usbnd Osbnd U) occur at 529.6-530.4 eV, bands for ( Odbnd Udbnd O) occur at 530.6-531.4 eV, bands for O 2- in the equatorial plane of the uranyl polyhedra linking uranyl polyhedra with ( TO n) groups ( T = Si, S, C, P, Se) ( Tsbnd O) occur at 530.9-532.2 eV; bands for (OH) groups in the equatorial plane of the uranyl polyhedra ( OH) occur at 532.0-532.5 eV, bands of (H 2O) groups in the interstitial complex of the uranyl minerals ( H2O interst) occur at 533.0-533.8 eV and bands of physisorbed (H 2O) groups on the surface of uranyl minerals ( H2O adsorb) occur at 534.8-535.2 eV. Treatment of uranyl minerals with acidic solutions results in a decrease in Usbnd Osbnd U and an increase in OH. Differences in the ratio of OH : Odbnd Udbnd O between the surface and bulk structure is larger for uranyl minerals with a high number of Usbnd Osbnd U and Tsbnd O species in the bulk structure which is explained by protonation of underbonded Usbnd O, Usbnd Osbnd U and Tsbnd O terminations on the surface. The difference in the ratio of H2O interst : Odbnd Udbnd O between the bulk and surface structures is larger for uranyl minerals with higher percentages of H2O

  9. Surface-core fiber gratings

    NASA Astrophysics Data System (ADS)

    Osório, Jonas H.; Oliveira, Ricardo; Mosquera, L.; Franco, Marcos A. R.; Heidarialamdarloo, Jamshid; Bilro, Lúcia; Nogueira, Rogério N.; Cordeiro, Cristiano M. B.

    2015-09-01

    In this paper, we report, to our knowledge, the first demonstration of the induction of long-period and Bragg gratings on surface-core optical fibers. Surface-core fibers described herein were fabricated from commercial silica tubes and germanium-doped silica rods by employing a very simple procedure. Being the core on the fiber surface, it can be sensitive to refractive index variations in the environment in which the fiber is immersed. Thus, results concerning the sensitivity of these gratings to environmental refractive index variations are presented. Besides, simulation data are presented for comparison to the experimental behavior and for projecting future steps in this research.

  10. Emotional awareness and core beliefs among women with eating disorders.

    PubMed

    Lawson, Rachel; Emanuelli, Francesca; Sines, Jennie; Waller, Glenn

    2008-03-01

    Patients with eating disorders have been shown to experience the emotional components of alexithymia-difficulties in identifying and describing emotions. In keeping with cognitive theories, which stress the role of schema-level beliefs in understanding emotions, this study examined the core beliefs that are associated with this difficulty in women with eating disorders. Seventy eating-disordered women completed standardised measures of core beliefs and alexithymia. There were no differences in alexithymia between diagnostic groups, so the women were treated as a single, transdiagnostic group. Multiple regression analyses showed specific patterns of association between the core beliefs and the emotional elements of alexithymia. Difficulties in identifying emotions were associated with entitlement beliefs, while difficulties in describing emotions were associated with both abandonment and emotional inhibition beliefs. These findings suggest that it may be necessary to work with core beliefs in order to reduce levels of alexithymia, prior to addressing the emotions that drive and maintain pathological eating behaviours.

  11. Characterizing Facesheet/Core Disbonding in Honeycomb Core Sandwich Structure

    NASA Technical Reports Server (NTRS)

    Rinker, Martin; Ratcliffe, James G.; Adams, Daniel O.; Krueger, Ronald

    2013-01-01

    Results are presented from an experimental investigation into facesheet core disbonding in carbon fiber reinforced plastic/Nomex honeycomb sandwich structures using a Single Cantilever Beam test. Specimens with three, six and twelve-ply facesheets were tested. Specimens with different honeycomb cores consisting of four different cell sizes were also tested, in addition to specimens with three different widths. Three different data reduction methods were employed for computing apparent fracture toughness values from the test data, namely an area method, a compliance calibration technique and a modified beam theory method. The compliance calibration and modified beam theory approaches yielded comparable apparent fracture toughness values, which were generally lower than those computed using the area method. Disbonding in the three-ply facesheet specimens took place at the facesheet/core interface and yielded the lowest apparent fracture toughness values. Disbonding in the six and twelve-ply facesheet specimens took place within the core, near to the facesheet/core interface. Specimen width was not found to have a significant effect on apparent fracture toughness. The amount of scatter in the apparent fracture toughness data was found to increase with honeycomb core cell size.

  12. Exotic phase transitions of k -cores in clustered networks

    NASA Astrophysics Data System (ADS)

    Bhat, Uttam; Shrestha, Munik; Hébert-Dufresne, Laurent

    2017-01-01

    The giant k -core—maximal connected subgraph of a network where each node has at least k neighbors—is important in the study of phase transitions and in applications of network theory. Unlike Erdős-Rényi graphs and other random networks where k -cores emerge discontinuously for k ≥3 , we show that transitive linking (or triadic closure) leads to 3-cores emerging through single or double phase transitions of both discontinuous and continuous nature. We also develop a k -core calculation that includes clustering and provides insights into how high-level connectivity emerges.

  13. Expression studies of the HCV-1a core+1 open reading frame in mammalian cells.

    PubMed

    Vassilaki, Niki; Boleti, Haralabia; Mavromara, Penelope

    2008-05-01

    The hepatitis C virus (HCV) genome possesses an open reading frame overlapping the core gene in the +1 frame (core+1 ORF). Initial studies, mainly in rabbit reticulocyte lysates, indicated that the HCV-1 core+1 ORF is expressed by a -2/+1 frameshift at codons 8-11 during translation elongation of the viral polyprotein, resulting in a protein known as alternative reading frame protein (ARFP), frameshift (F), or core+1. However, subsequent investigation, based on reporter constructs carrying portions of the core+1 ORF, suggested the function of alternative mechanisms for core+1 expression in mammalian cells, including translation initiation from internal codons 85/87 or 26. Because results from these studies have been variable, we sought to re-evaluate expression of the core+1 ORF using constructs carrying the complete core+1 coding sequence fused to GFP or LUC. We showed here that codons 85/87 serve as the predominant initiation sites for internal translation initiation of core+1 ORF in Huh-7 and Huh-7/T7 mammalian cells, which support nuclear or cytoplasmic transcription, respectively. We also showed that internal translation initiation can occur concomitantly with the expression of the core+1/F protein that is produced artificially in Huh-7 or naturally in Huh-7/T7 cells. Furthermore, translation of core+1 ORF is not significantly affected by the presence of the HCV IRES element. The core+1/S-GFP protein is cytoplasmic and exhibits an ER distribution similar to that of the core+1/F-GFP protein.

  14. [PCR-based analysis of the D1S80 locus and its application in paternity test].

    PubMed

    Que, T; Lin, Y; Li, L

    1998-01-01

    Allelic data for the D1S80 locus was obtained by using the PCR and subsequent analysis with high-resolution horizontal PAGE technique. In a sample of 184 unrelated Chinese, the D1S80 locus had 75 phenotypes and 20 allelic. The distribution of genotype was in agreement with expected values according to the Hardy-Weinberg equilibrium. Analysis of the D1S80 locus by the PCR has been successfully applied in 150 cases of questioned paternity.

  15. Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1

    SciTech Connect

    Tao Yongguang; Song Xing; Deng Xiyun; Xie Daxin; Lee, Leo M.; Liu Yiping; Li Wei; Li Lili; Deng Lin; Wu Qiao; Gong Jianping; Cao Ya . E-mail: ycao98@public.cs.hn.cn

    2005-02-15

    Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is considered to be the major oncogenic protein of EBV-encoded proteins and has always been the core of the oncogenic mechanism of EBV. Advanced studies on nuclear translocation of the epidermal growth factor receptor (EGFR) family have greatly improved our knowledge of the biological function of cell surface receptors. In this study, we used the Tet-on LMP1 HNE2 cell line as a cell model, which is a dual-stable LMP1-integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 which could be regulated by the Tet system. We found that LMP1 could regulate the nuclear accumulation of EGFR in a dose-dependent manner quantitatively and qualitatively. We also demonstrated that the nuclear localization sequence of EGFR played some roles in the location of the protein within the nucleus under LMP1 regulation and EGFR in the nucleus could bind to the promoters of cyclinD1 and cyclinE, respectively. We further demonstrated that EGFR is involved in the acceleration of the G1/S phase transition by LMP1 through binding to cyclinD1 and cyclinE directly. These findings provided a novel view that the acceleration of LMP1 on the G1/S transition via the nuclear accumulation of EGFR was critical in the process of nasopharyngeal carcinoma.

  16. Tracking hole localization in K -shell and core-valence-excited acetylene photoionization via body-frame photoelectron angular distributions

    NASA Astrophysics Data System (ADS)

    Rescigno, T. N.; Trevisan, C. S.; McCurdy, C. W.

    2015-02-01

    Asymmetry in the molecular-frame photoelectron angular distributions from core-hole- or core-valence-excited polyatomic targets with symmetry-equivalent atoms can provide direct evidence for core-hole localization. Using acetylene as an example, we contrast the small asymmetry that can be seen in direct core-level ionization, due to the competition between two competing pathways to the continuum, with ionization from core-valence-excited HCCH, which offers the prospect of observing markedly greater asymmetry.

  17. When the Earth's Inner Core Shuffles

    NASA Astrophysics Data System (ADS)

    Tkalcic, H.; Young, M. K.; Bodin, T.; Ngo, S.; Sambridge, M.

    2011-12-01

    Shuffling is a tribal dance recently adapted by teenagers as a street dance. In one of the most popular moves, the so-called "Running Man", a stomp forward on one foot, shifted without being lifted from the ground, is followed by a change of position backwards on the same foot. Here, we present strong observational evidence from a newly observed collection of earthquake doublets that the Earth's inner core "shuffles" exhibiting both prograde and retrograde rotation in the reference frame of the mantle. This discovery is significant on several levels. First, the observed pattern consists of intermittent intervals of quasi-locked and differentially rotating inner core with respect to the Earth's mantle. This means that the angular alignment of the inner core and mantle oscillates in time over the past five decades. Jolting temporal changes are revealed, indicating that during the excursions from the quasi-locked state, the Earth's inner core can rotate both faster and slower than the rest of the planet, thus exhibiting both eastward and westward rotation. According to our results, a short time interval (on the order of one to two years) is needed for the inner core to accelerate to a differential rotation rate of several degrees per year, and typically a slightly longer time is needed to decelerate down to a negligibly small differential rotation rate. These time scales are in agreement with experimental spin-up times obtained when the magnetic torque alone is used to accelerate the inner core. Second, when we integrate the rotation rate over different time intervals, it is possible to explain discrepancies between the body wave and normal modes results for the rate of the inner core differential rotation found by previous authors. We show that the integrated shift in angular alignment and average rotation rates (previously determined to be constant) in normal mode studies are much smaller that those for the body waves. The repeating earthquakes from the South

  18. Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE

    SciTech Connect

    Lee, Sungsoo; Wang, Ping-Yuan; Jeong, Yangsik; Mangelsdorf, David J.; Anderson, Richard G.W.; Michaely, Peter

    2012-10-01

    Oxysterol binding protein related protein 1S (ORP1S) is a member of a family of sterol transport proteins. Here we present evidence that ORP1S translocates from the cytoplasm to the nucleus in response to sterol binding. The sterols that best promote nuclear import of ORP1S also activate the liver X receptor (LXR) transcription factors and we show that ORP1S binds to LXRs, promotes binding of LXRs to LXR response elements (LXREs) and specifically enhances LXR-dependent transcription via the ME.1 and ME.2 enhancer elements of the apoE gene. We propose that ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR-dependent gene transcription through select enhancer elements. -- Highlights: Black-Right-Pointing-Pointer ORP1S translocates to the nucleus in response to sterol binding. Black-Right-Pointing-Pointer The sterols that best promote nuclear import of ORP1S are LXR agonists. Black-Right-Pointing-Pointer ORP1S binds to LXRs, enhances binding of LXRs to LXREs and promotes LXR-dependent transcription of apoE.

  19. NEW SOIL VOC SAMPLERS: EN CORE AND ACCU CORE SAMPLING/STORAGE DEVICES FOR VOC ANALYSIS

    SciTech Connect

    Susan S. Sorini; John F. Schabron; Joseph F. Rovani Jr

    2006-06-01

    Soil sampling and storage practices for volatile organic analysis must be designed to minimize loss of volatile organic compounds (VOCs) from samples. The En Core{reg_sign} sampler is designed to collect and store soil samples in a manner that minimizes loss of contaminants due to volatilization and/or biodegradation. An ASTM International (ASTM) standard practice, D 6418, Standard Practice for Using the Disposable En Core Sampler for Sampling and Storing Soil for Volatile Organic Analysis, describes use of the En Core sampler to collect and store a soil sample of approximately 5 grams or 25 grams for volatile organic analysis and specifies sample storage in the En Core sampler at 4 {+-} 2 C for up to 48 hours; -7 to -21 C for up to 14 days; or 4 {+-} 2 C for up to 48 hours followed by storage at -7 to -21 C for up to five days. This report discusses activities performed during the past year to promote and continue acceptance of the En Core samplers based on their performance to store soil samples for VOC analysis. The En Core sampler is designed to collect soil samples for VOC analysis at the soil surface. To date, a sampling tool for collecting and storing subsurface soil samples for VOC analysis is not available. Development of a subsurface VOC sampling/storage device was initiated in 1999. This device, which is called the Accu Core{trademark} sampler, is designed so that a soil sample can be collected below the surface using a dual-tube penetrometer and transported to the laboratory for analysis in the same container. Laboratory testing of the current Accu Core design shows that the device holds low-level concentrations of VOCs in soil samples during 48-hour storage at 4 {+-} 2 C and that the device is ready for field evaluation to generate additional performance data. This report discusses a field validation exercise that was attempted in Pennsylvania in 2004 and activities being performed to plan and conduct a field validation study in 2006. A draft ASTM

  20. Assessing Core Competencies

    NASA Astrophysics Data System (ADS)

    Narayanan, M.

    2004-12-01

    Catherine Palomba and Trudy Banta offer the following definition of assessment, adapted from one provided by Marches in 1987. Assessment in the systematic collection, review, and use of information about educational programs undertaken for the purpose of improving student learning and development. (Palomba and Banta 1999). It is widely recognized that sophisticated computing technologies are becoming a key element in today's classroom instructional techniques. Regardless, the Professor must be held responsible for creating an instructional environment in which the technology actually supplements learning outcomes of the students. Almost all academic disciplines have found a niche for computer-based instruction in their respective professional domain. In many cases, it is viewed as an essential and integral part of the educational process. Educational institutions are committing substantial resources to the establishment of dedicated technology-based laboratories, so that they will be able to accommodate and fulfill students' desire to master certain of these specific skills. This type of technology-based instruction may raise some fundamental questions about the core competencies of the student learner. Some of the most important questions are : 1. Is the utilization of these fast high-powered computers and user-friendly software programs creating a totally non-challenging instructional environment for the student learner ? 2. Can technology itself all too easily overshadow the learning outcomes intended ? 3. Are the educational institutions simply training students how to use technology rather than educating them in the appropriate field ? 4. Are we still teaching content-driven courses and analysis oriented subject matter ? 5. Are these sophisticated modern era technologies contributing to a decline in the Critical Thinking Capabilities of the 21st century technology-savvy students ? The author tries to focus on technology as a tool and not on the technology